               SEQUENCE LISTING

<110> Technische Universität München
      Institute of Biotechnology CAS, v.v.i.

<120> Humanized Anti-PSMA Antibody

<130> AD3680 PCT

<150> EP 21 173 577.4
<151> 2021-05-12

<160> 34

<170> BiSSAP 1.3.6

<210> 1
<211> 119
<212> PRT
<213> Artificial Sequence


<220> 
<223> Humanized 5D3-6 - heavy chain

<400> 1
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ala Phe Asn Thr Ser 
            20                  25                  30          
Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Ser Arg Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe 
    50                  55                  60                  
Lys Gly Lys Ala Thr Ile Ser Ala Asp Lys Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Glu Trp Tyr Leu Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser 
        115                 

<210> 2
<211> 107
<212> PRT
<213> Artificial Sequence


<220> 
<223> Humanized 5D3-6 - light chain

<400> 2
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Gln Gly Ile Asn Asn Phe 
            20                  25                  30          
Leu Thr Trp Tyr Gln Gln Lys Pro Gly Lys Ala Leu Lys Leu Leu Ile 
        35                  40                  45              
Tyr Tyr Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Leu Pro Phe 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         

<210> 3
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> Humanized 5D3-6 - heavy chain

<400> 3
Gly Tyr Ala Phe Asn Thr Ser Trp Met Asn 
1               5                   10  

<210> 4
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> Humanized 5D3-6 - heavy chain

<400> 4
Arg Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe Lys 
1               5                   10                  15      
Gly 
    

<210> 5
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> Humanized 5D3-6 - heavy chain

<400> 5
Gly Glu Trp Tyr Leu Tyr Tyr Phe Asp Tyr 
1               5                   10  

<210> 6
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> Humanized 5D3-6 - light chain

<400> 6
Ser Ala Ser Gln Gly Ile Asn Asn Phe Leu Thr 
1               5                   10      

<210> 7
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> Humanized 5D3-6 - light chain

<400> 7
Tyr Thr Ser Ser Leu His Ser 
1               5           

<210> 8
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> Humanized 5D3-6 - light chain

<400> 8
Gln Gln Tyr Ser Asn Leu Pro Phe Thr 
1               5                   

<210> 9
<211> 357
<212> DNA
<213> Artificial Sequence


<220> 
<223> Humanized 5D3-6 - heavy chain

<400> 9
gaagttcaac tggtggaaag cggtggtggt ctggttcagc ctggtggtag cctgcgtctg      60

agctgtgcag caagcggtta tgcatttaat accagctgga tgaattgggt tcgtcaggca     120

cctggtaaag gtctggaatg gattagccgt atttatcctg gtgatggtga taccaactat     180

aacggtaaat tcaaaggcaa agcaaccatc agcgcagaca aaagcaaaaa taccctgtac     240

ctgcaaatga atagtctgcg tgcagaggat accgcagtgt attattgtgc acgtggtgaa     300

tggtatctgt actattttga ttattggggt cagggcaccc tggtcaccgt ctcctca        357


<210> 10
<211> 321
<212> DNA
<213> Artificial Sequence


<220> 
<223> Humanized 5D3-6 - light chain

<400> 10
gacatccaga tgacccagag tccgagcagc ctgagcgcaa gcgttggtga tcgtgttacc      60

attacctgta gcgccagcca gggtattaac aattttctga cctggtatca gcagaaaccg     120

ggtaaagcac tgaaactgct gatctattat accagcagcc tgcatagcgg tgttccgagc     180

cgttttagcg gtagcggtag tggcaccgat tataccctga ccattagcag tctgcaaccg     240

gaagattttg caacctatta ttgtcagcag tatagcaatc tgccgtttac ctttggtcag     300

ggcaccaaag tcgagatcaa a                                               321


<210> 11
<211> 30
<212> DNA
<213> Artificial Sequence


<220> 
<223> Humanized 5D3-6 - heavy chain

<400> 11
ggttatgcat ttaataccag ctggatgaat                                     30


<210> 12
<211> 51
<212> DNA
<213> Artificial Sequence


<220> 
<223> Humanized 5D3-6 - heavy chain

<400> 12
cgtatttatc ctggtgatgg tgataccaac tataacggta aattcaaagg c              51


<210> 13
<211> 30
<212> DNA
<213> Artificial Sequence


<220> 
<223> Humanized 5D3-6 - heavy chain

<400> 13
ggtgaatggt atctgtacta ttttgattat                                     30


<210> 14
<211> 33
<212> DNA
<213> Artificial Sequence


<220> 
<223> Humanized 5D3-6 - light chain

<400> 14
agcgccagcc agggtattaa caattttctg acc                                  33


<210> 15
<211> 21
<212> DNA
<213> Artificial Sequence


<220> 
<223> Humanized 5D3-6 - light chain

<400> 15
tataccagca gcctgcatag c                                              21


<210> 16
<211> 27
<212> DNA
<213> Artificial Sequence


<220> 
<223> Humanized 5D3-6 - light chain

<400> 16
cagcagtata gcaatctgcc gtttacc                                        27


<210> 17
<211> 119
<212> PRT
<213> Artificial Sequence


<220> 
<223> 5D3 mAb - heavy chain

<400> 17
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Ala Phe Asn Thr Ser 
            20                  25                  30          
Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Arg Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe 
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala His 
65                  70                  75                  80  
Met His Leu Ser Ser Leu Thr Ser Val Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      
Ala Arg Gly Glu Trp Tyr Leu Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         
Thr Thr Leu Thr Val Ser Ser 
        115                 

<210> 18
<211> 107
<212> PRT
<213> Artificial Sequence


<220> 
<223> 5D3 mAb - light chain

<400> 18
Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Ser Cys Ser Ala Ser Gln Gly Ile Asn Asn Phe 
            20                  25                  30          
Leu Thr Trp Tyr Gln Gln Lys Pro Asp Gly Thr Leu Lys Leu Leu Ile 
        35                  40                  45              
Tyr Tyr Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Arg Asn Leu Glu Pro 
65                  70                  75                  80  
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Leu Pro Phe 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         

<210> 19
<211> 357
<212> DNA
<213> Artificial Sequence


<220> 
<223> 5D3 mAb - heavy chain

<400> 19
gaggttcagc ttcagcagtc tggacctgaa ctggtgaagc ctggggcctc agtgaagatt      60

tcctgcaaaa cttctggcta cgcattcaat acctcttgga tgaactgggt gaagcagagg     120

cctggacagg gtcttgagtg gattggacgg atttatcctg gagatggaga tactaactac     180

aatgggaagt tcaagggcaa ggccacactg actgcagaca aatcctccag cacagcccac     240

atgcacctca gcagtctgac ctctgtggat tctgcggtct atttctgtgc aagaggagaa     300

tggtaccttt actactttga ctactggggc caaggcacca ctctcacagt ctcctca        357


<210> 20
<211> 321
<212> DNA
<213> Artificial Sequence


<220> 
<223> 5D3 mAb - light chain

<400> 20
gacatccaga tgacccagac aacatcctcc ctgtctgcct ctctgggaga cagagtcacc      60

atcagttgca gtgcaagtca gggcattaac aattttttaa cctggtatca gcagaaacca     120

gatggaactc ttaaactcct gatctattac acatcaagtt tacactcagg agtcccatca     180

aggttcagtg gcagtgggtc tgggacagat tattctctca ccattaggaa cctggaacct     240

gaagatattg ccacttacta ttgtcagcaa tatagtaacc ttccgttcac gttcggaggg     300

gggaccaagg tggaaataaa a                                               321


<210> 21
<211> 119
<212> PRT
<213> Artificial Sequence


<220> 
<223> Humanized 5D3-2 - heavy chain

<400> 21
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Asn Thr Ser 
            20                  25                  30          
Trp Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Tyr Ile 
        35                  40                  45              
Gly Arg Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe 
    50                  55                  60                  
Lys Gly Lys Ala Thr Met Thr Ala Asp Lys Ser Ile Ser Thr Val Tyr 
65                  70                  75                  80  
Met Glu Val Arg Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Glu Trp Tyr Leu Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser 
        115                 

<210> 22
<211> 107
<212> PRT
<213> Artificial Sequence


<220> 
<223> Humanized 5D3-2 - light chain

<400> 22
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Gln Gly Ile Asn Asn Phe 
            20                  25                  30          
Leu Thr Trp Tyr Gln His Glu Pro Gly Lys Ala Leu Lys Leu Leu Ile 
        35                  40                  45              
Tyr Tyr Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Thr Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Leu Pro Phe 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         

<210> 23
<211> 357
<212> DNA
<213> Artificial Sequence


<220> 
<223> Humanized 5D3-2 - heavy chain

<400> 23
caagttcaac tggtgcagag cggtgccgaa gttaaaaaac cgggtgcaag cgttaaagtt      60

agctgtaaag caagcggtta tgcctttaat accagctgga tgaattgggt tcgtcaggca     120

cctggtcaag gtctggaata cattggtcgt atttatcctg gtgatggcga taccaactat     180

aacggtaaat tcaaaggtaa agcaaccatg accgcagata aaagcattag caccgtttat     240

atggaagttc gtcgtctgcg tagtgatgat accgcagtgt attattgtgc acgtggtgaa     300

tggtatctgt actattttga ttattggggt cagggcaccc tggtcaccgt ctcctca        357


<210> 24
<211> 321
<212> DNA
<213> Artificial Sequence


<220> 
<223> Humanized 5D3-2 - light chain

<400> 24
gacatccaga tgacccagag tccgagcagc ctgagcgcaa gcgttggtga tcgtgttacc      60

attacctgta gcgccagcca gggtattaac aattttctga cctggtatca gcatgaaccg     120

ggtaaagcac tgaaactgct gatctattat accagcagcc tgcatagcgg tgttccgagc     180

cgttttagcg gtagcggtag tggcaccgat tataccctga ccattagcac cctgcagccg     240

gaagattttg caacctatta ttgtcagcag tatagcaatc tgccgtttac ctttggtggt     300

ggcaccaaag tcgagatcaa a                                               321


<210> 25
<211> 119
<212> PRT
<213> Artificial Sequence


<220> 
<223> Humanized 5D3-5 - heavy chain

<400> 25
Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Arg Leu Ser Cys Lys Ala Ser Gly Tyr Ala Phe Asn Thr Ser 
            20                  25                  30          
Trp Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Arg Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe 
    50                  55                  60                  
Lys Gly Lys Ala Thr Met Thr Ala Asp Lys Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Gly Arg Gly Glu Trp Tyr Leu Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser 
        115                 

<210> 26
<211> 107
<212> PRT
<213> Artificial Sequence


<220> 
<223> Humanized 5D3-5 - light chain

<400> 26
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Ser Cys Ser Ala Ser Gln Gly Ile Asn Asn Phe 
            20                  25                  30          
Leu Thr Trp Tyr Gln Gln Lys Leu Gly Lys Ala Leu Gln Leu Leu Ile 
        35                  40                  45              
Tyr Tyr Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Leu Pro Phe 
                85                  90                  95      
Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105         

<210> 27
<211> 357
<212> DNA
<213> Artificial Sequence


<220> 
<223> Humanized 5D3-5 - heavy chain

<400> 27
caagttcaac tggtgcagag cggtccggaa gttaaaaaac cgggtgcaag cgttcgtctg      60

agctgtaaag caagcggtta tgcatttaat accagctgga tgaattgggt tcgtcaggca     120

cctggtcaag gtctggaatg gattggtcgt atttatcctg gtgatggtga taccaactat     180

aacggtaaat tcaaaggtaa agcaaccatg accgcagata aaagcaccaa taccgcatat     240

atggaactgc gtagcctgcg tagtgatgat accgcagtgt attattgtgg tcgtggtgaa     300

tggtatctgt actattttga ttattggggt cagggcaccc tggtcaccgt ctcctca        357


<210> 28
<211> 321
<212> DNA
<213> Artificial Sequence


<220> 
<223> Humanized 5D3-5 - light chain

<400> 28
gacatccaga tgacacagag cccgagcagc gttagcgcaa gcgttggtga tcgtgttacc      60

attagctgta gcgccagcca gggtattaac aattttctga cctggtatca gcagaaactg     120

ggtaaagcac tgcaactgct gatctattat accagcagcc tgcatagcgg tgttccgagc     180

cgttttagcg gtagcggtag tggcaccgat tataccctga ccattagcag tctgcaaccg     240

gaagattttg caacctatta ttgtcagcag tatagcaatc tgccgtttac ctttggtccg     300

ggtacaaaag tcgatatcaa a                                               321


<210> 29
<211> 750
<212> PRT
<213> Homo sapiens


<220> 
<223> Isoform PSMA-1

<400> 29
Met Trp Asn Leu Leu His Glu Thr Asp Ser Ala Val Ala Thr Ala Arg 
1               5                   10                  15      
Arg Pro Arg Trp Leu Cys Ala Gly Ala Leu Val Leu Ala Gly Gly Phe 
            20                  25                  30          
Phe Leu Leu Gly Phe Leu Phe Gly Trp Phe Ile Lys Ser Ser Asn Glu 
        35                  40                  45              
Ala Thr Asn Ile Thr Pro Lys His Asn Met Lys Ala Phe Leu Asp Glu 
    50                  55                  60                  
Leu Lys Ala Glu Asn Ile Lys Lys Phe Leu Tyr Asn Phe Thr Gln Ile 
65                  70                  75                  80  
Pro His Leu Ala Gly Thr Glu Gln Asn Phe Gln Leu Ala Lys Gln Ile 
                85                  90                  95      
Gln Ser Gln Trp Lys Glu Phe Gly Leu Asp Ser Val Glu Leu Ala His 
            100                 105                 110         
Tyr Asp Val Leu Leu Ser Tyr Pro Asn Lys Thr His Pro Asn Tyr Ile 
        115                 120                 125             
Ser Ile Ile Asn Glu Asp Gly Asn Glu Ile Phe Asn Thr Ser Leu Phe 
    130                 135                 140                 
Glu Pro Pro Pro Pro Gly Tyr Glu Asn Val Ser Asp Ile Val Pro Pro 
145                 150                 155                 160 
Phe Ser Ala Phe Ser Pro Gln Gly Met Pro Glu Gly Asp Leu Val Tyr 
                165                 170                 175     
Val Asn Tyr Ala Arg Thr Glu Asp Phe Phe Lys Leu Glu Arg Asp Met 
            180                 185                 190         
Lys Ile Asn Cys Ser Gly Lys Ile Val Ile Ala Arg Tyr Gly Lys Val 
        195                 200                 205             
Phe Arg Gly Asn Lys Val Lys Asn Ala Gln Leu Ala Gly Ala Lys Gly 
    210                 215                 220                 
Val Ile Leu Tyr Ser Asp Pro Ala Asp Tyr Phe Ala Pro Gly Val Lys 
225                 230                 235                 240 
Ser Tyr Pro Asp Gly Trp Asn Leu Pro Gly Gly Gly Val Gln Arg Gly 
                245                 250                 255     
Asn Ile Leu Asn Leu Asn Gly Ala Gly Asp Pro Leu Thr Pro Gly Tyr 
            260                 265                 270         
Pro Ala Asn Glu Tyr Ala Tyr Arg Arg Gly Ile Ala Glu Ala Val Gly 
        275                 280                 285             
Leu Pro Ser Ile Pro Val His Pro Ile Gly Tyr Tyr Asp Ala Gln Lys 
    290                 295                 300                 
Leu Leu Glu Lys Met Gly Gly Ser Ala Pro Pro Asp Ser Ser Trp Arg 
305                 310                 315                 320 
Gly Ser Leu Lys Val Pro Tyr Asn Val Gly Pro Gly Phe Thr Gly Asn 
                325                 330                 335     
Phe Ser Thr Gln Lys Val Lys Met His Ile His Ser Thr Asn Glu Val 
            340                 345                 350         
Thr Arg Ile Tyr Asn Val Ile Gly Thr Leu Arg Gly Ala Val Glu Pro 
        355                 360                 365             
Asp Arg Tyr Val Ile Leu Gly Gly His Arg Asp Ser Trp Val Phe Gly 
    370                 375                 380                 
Gly Ile Asp Pro Gln Ser Gly Ala Ala Val Val His Glu Ile Val Arg 
385                 390                 395                 400 
Ser Phe Gly Thr Leu Lys Lys Glu Gly Trp Arg Pro Arg Arg Thr Ile 
                405                 410                 415     
Leu Phe Ala Ser Trp Asp Ala Glu Glu Phe Gly Leu Leu Gly Ser Thr 
            420                 425                 430         
Glu Trp Ala Glu Glu Asn Ser Arg Leu Leu Gln Glu Arg Gly Val Ala 
        435                 440                 445             
Tyr Ile Asn Ala Asp Ser Ser Ile Glu Gly Asn Tyr Thr Leu Arg Val 
    450                 455                 460                 
Asp Cys Thr Pro Leu Met Tyr Ser Leu Val His Asn Leu Thr Lys Glu 
465                 470                 475                 480 
Leu Lys Ser Pro Asp Glu Gly Phe Glu Gly Lys Ser Leu Tyr Glu Ser 
                485                 490                 495     
Trp Thr Lys Lys Ser Pro Ser Pro Glu Phe Ser Gly Met Pro Arg Ile 
            500                 505                 510         
Ser Lys Leu Gly Ser Gly Asn Asp Phe Glu Val Phe Phe Gln Arg Leu 
        515                 520                 525             
Gly Ile Ala Ser Gly Arg Ala Arg Tyr Thr Lys Asn Trp Glu Thr Asn 
    530                 535                 540                 
Lys Phe Ser Gly Tyr Pro Leu Tyr His Ser Val Tyr Glu Thr Tyr Glu 
545                 550                 555                 560 
Leu Val Glu Lys Phe Tyr Asp Pro Met Phe Lys Tyr His Leu Thr Val 
                565                 570                 575     
Ala Gln Val Arg Gly Gly Met Val Phe Glu Leu Ala Asn Ser Ile Val 
            580                 585                 590         
Leu Pro Phe Asp Cys Arg Asp Tyr Ala Val Val Leu Arg Lys Tyr Ala 
        595                 600                 605             
Asp Lys Ile Tyr Ser Ile Ser Met Lys His Pro Gln Glu Met Lys Thr 
    610                 615                 620                 
Tyr Ser Val Ser Phe Asp Ser Leu Phe Ser Ala Val Lys Asn Phe Thr 
625                 630                 635                 640 
Glu Ile Ala Ser Lys Phe Ser Glu Arg Leu Gln Asp Phe Asp Lys Ser 
                645                 650                 655     
Asn Pro Ile Val Leu Arg Met Met Asn Asp Gln Leu Met Phe Leu Glu 
            660                 665                 670         
Arg Ala Phe Ile Asp Pro Leu Gly Leu Pro Asp Arg Pro Phe Tyr Arg 
        675                 680                 685             
His Val Ile Tyr Ala Pro Ser Ser His Asn Lys Tyr Ala Gly Glu Ser 
    690                 695                 700                 
Phe Pro Gly Ile Tyr Asp Ala Leu Phe Asp Ile Glu Ser Lys Val Asp 
705                 710                 715                 720 
Pro Ser Lys Ala Trp Gly Glu Val Lys Arg Gln Ile Tyr Val Ala Ala 
                725                 730                 735     
Phe Thr Val Gln Ala Ala Ala Glu Thr Leu Ser Glu Val Ala 
            740                 745                 750 

<210> 30
<211> 119
<212> PRT
<213> Artificial Sequence


<220> 
<223> Consensus VH

<220> 
<221> VARIANT
<222> 30
<223> Gly, Ala, Val, Leu, Ile, Tyr, His, Lys, Arg, Gln, Asn, Glu, Asp,
      Ser or Thr

<220> 
<221> VARIANT
<222> 31
<223> Pro or Thr

<220> 
<221> VARIANT
<222> 32
<223> Gly, Ala, Val, Leu, Ile, Tyr, His, Lys, Arg, Gln, Asn, Glu, Asp,
      Thr or Ser

<220> 
<221> VARIANT
<222> 34
<223> Met, Ile or Leu

<220> 
<221> VARIANT
<222> 55
<223> Gly, Ala, Val, Leu, Ile, Tyr, His, Gln, Asn, Glu, Asp, Ser or Thr

<220> 
<221> VARIANT
<222> 56
<223> Gly, Ala, Val, Leu, Ile, His, Lys, Arg, Gln, Asn, Glu, Asp, Ser
      or Thr

<220> 
<221> VARIANT
<222> 57
<223> Gly, Ala, Val, Leu, Ile, Tyr, His, Gln, Asn, Glu, Asp, Ser or Thr

<220> 
<221> VARIANT
<222> 58
<223> Gly, Ala, Val, Leu, His, Gln, Asn, Glu, Asp, Ser or Thr

<220> 
<221> VARIANT
<222> 61
<223> Gly, Ala, Val, Leu, Ile, Tyr, His, Lys, Arg, Gln, Asn, Glu, Asp,
      Ser or Thr

<220> 
<221> VARIANT
<222> 62
<223> Gly, Ala, Val, Leu, Ile, Tyr, His, Lys, Arg, Gln, Asn, Glu, Asp,
      Ser or Thr

<400> 30
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ala Phe Xaa Xaa Xaa 
            20                  25                  30          
Trp Xaa Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Ser Arg Ile Tyr Pro Gly Xaa Xaa Xaa Xaa Asn Tyr Xaa Xaa Lys Phe 
    50                  55                  60                  
Lys Gly Lys Ala Thr Ile Ser Ala Asp Lys Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Glu Trp Tyr Leu Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser 
        115                 

<210> 31
<211> 107
<212> PRT
<213> Artificial Sequence


<220> 
<223> Consensus VL

<220> 
<221> VARIANT
<222> 30
<223> Gly, Ala, Val, Leu, Ile, Tyr, His, Lys, Arg, Gln, Asn, Glu, Asp,
      Ser or Thr

<220> 
<221> VARIANT
<222> 31
<223> Gly, Ala, Val, Leu, Ile, Tyr, His, Lys, Arg, Gln, Asn, Glu, Asp,
      Ser or Thr

<400> 31
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Gln Gly Ile Xaa Xaa Phe 
            20                  25                  30          
Leu Thr Trp Tyr Gln Gln Lys Pro Gly Lys Ala Leu Lys Leu Leu Ile 
        35                  40                  45              
Tyr Tyr Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Leu Pro Phe 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         

<210> 32
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> Consensus VH CDR 1

<220> 
<221> VARIANT
<222> 5
<223> Gly, Ala, Val, Leu, Ile, Tyr, His, Lys, Arg, Gln, Asn, Glu, Asp,
      Ser or Thr

<220> 
<221> VARIANT
<222> 6
<223> Pro or Thr

<220> 
<221> VARIANT
<222> 7
<223> Gly, Ala, Val, Leu, Ile, Tyr, His, Lys, Arg, Gln, Asn, Glu, Asp,
      Thr or Ser

<220> 
<221> VARIANT
<222> 9
<223> Met, Ile or Leu

<400> 32
Gly Tyr Ala Phe Xaa Xaa Xaa Trp Xaa Asn 
1               5                   10  

<210> 33
<211> 16
<212> PRT
<213> Artificial Sequence


<220> 
<223> Consensus VH CDR2

<220> 
<221> VARIANT
<222> 6
<223> Gly, Ala, Val, Leu, Ile, Tyr, His, Gln, Asn, Glu, Asp, Ser or Thr

<220> 
<221> VARIANT
<222> 7
<223> Gly, Ala, Val, Leu, Ile, His, Lys, Arg, Gln, Asn, Glu, Asp, Ser
      or Thr

<220> 
<221> VARIANT
<222> 8
<223> Gly, Ala, Val, Leu, Ile, Tyr, His, Gln, Asn, Glu, Asp, Ser or Thr

<220> 
<221> VARIANT
<222> 9
<223> Gly, Ala, Val, Leu, His, Gln, Asn, Glu, Asp, Ser or Thr

<220> 
<221> VARIANT
<222> 12
<223> Gly, Ala, Val, Leu, Ile, Tyr, His, Lys, Arg, Gln, Asn, Glu, Asp,
      Ser or Thr

<220> 
<221> VARIANT
<222> 13
<223> Gly, Ala, Val, Leu, Ile, Tyr, His, Lys, Arg, Gln, Asn, Glu, Asp,
      Ser or Thr

<400> 33
Arg Ile Tyr Pro Gly Xaa Xaa Xaa Xaa Asn Tyr Xaa Xaa Lys Phe Lys 
1               5                   10                  15      



<210> 34
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> Consensus VL CDR1

<220> 
<221> VARIANT
<222> 7
<223> Gly, Ala, Val, Leu, Ile, Tyr, His, Lys, Arg, Gln, Asn, Glu, Asp,
      Ser or Thr

<220> 
<221> VARIANT
<222> 8
<223> Gly, Ala, Val, Leu, Ile, Tyr, His, Lys, Arg, Gln, Asn, Glu, Asp,
      Ser or Thr

<400> 34
Ser Ala Ser Gln Gly Ile Xaa Xaa Phe Leu Thr 
1               5                   10      

