                         SEQUENCE LISTING

<110>  Industry-Academic Cooperation Foundation, Yonsei University
 
<120>  Guide RNA for detecting oncogenic mutations and uses thereof

<130>  PCT5041064

<150>  KR 10-2021-0061037
<151>  2021-05-11

<160>  43    

<170>  PatentIn version 3.2

<210>  1
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  EGFR (p.T790M) WT sgRNA

<400>  1
ctgcgtgatg agctgcacgg tgg                                             23


<210>  2
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  EGFR (p.T790M) Mut sgRNA

<400>  2
ctgcgtgctg agctgcacgg tgg                                             23


<210>  3
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  EGFR (p.C797S) WT sgRNA

<400>  3
catgcccttc ggctgcctcc tgg                                             23


<210>  4
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  EGFR (p.C797S) Mut sgRNA

<400>  4
catgcacttc ggctgcctcc tgg                                             23


<210>  5
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  MET c.2888 Int13-Exon14 Acceptor (Exon-14 Skipping) WT sgRNA

<400>  5
tttctctctg ttttaagatc tgg                                             23


<210>  6
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  MET c.3028 Exon14-Int14 Donor (Exon-14 Skipping) WT sgRNA

<400>  6
ataaactgaa atataccttc tgg                                             23


<210>  7
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  MET 'TAC' Y1003X (Exon-14 Skipping) WT sgRNA

<400>  7
aaatgaatct gtagactacc gag                                             23


<210>  8
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  EGFR (L718Q) WT sgRNA

<400>  8
aagatcaaag tgctgggctc cgg                                             23


<210>  9
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  EGFR (L718Q) Mut sgRNA

<400>  9
aagatcacag tgctgggctc cgg                                             23


<210>  10
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  KRAS (c.35G) WT sgRNA

<400>  10
aaacttgtgg tagttggagc tgg                                             23


<210>  11
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  EGFR, 15bp Del p.(E746_A750) WT sgRNA

<400>  11
taaaattccc gtcgctatca agg                                             23


<210>  12
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  EGFR (p.L858R) WT sgRNA

<400>  12
ttttgggctg gccaaactgc tgg                                             23


<210>  13
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  EGFR (p.L858R) Mut sgRNA

<400>  13
ttttgtgctg gccaaactgc tgg                                             23


<210>  14
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  PIK3CA p.E542K or c.1624G>A WT sgRNA

<400>  14
tgctcagtga tttcagagag agg                                             23


<210>  15
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  PIK3CA p.E545? or c.1633G>? WT sgRNA

<400>  15
tctctctgaa atcactgagc agg                                             23


<210>  16
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  PIK3CA p.H1047? or c.3140A>? WT sgRNA

<400>  16
caaatgaatg atgcacatca tgg                                             23


<210>  17
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  BRAF p.V600E or c.1799T>A WT sgRNA

<400>  17
tagctacagt gaaatctcga tgg                                             23


<210>  18
<211>  41
<212>  DNA
<213>  Artificial

<220>
<223>  EGFR (p.T790M) WT IVT

<400>  18
tcacctccac cgtgcagctc atcacgcagc tcatgccctt c                         41


<210>  19
<211>  41
<212>  DNA
<213>  Artificial

<220>
<223>  EGFR (p.T790M) Mut IVT

<400>  19
tcacctccac cgtgcagctc atcatgcagc tcatgccctt c                         41


<210>  20
<211>  41
<212>  DNA
<213>  Artificial

<220>
<223>  EGFR (p.C797S) WT IVT

<400>  20
acgcagctca tgcccttcgg ctgcctcctg gactatgtcc g                         41


<210>  21
<211>  41
<212>  DNA
<213>  Artificial

<220>
<223>  EGFR (p.C797S) Mut IVT

<400>  21
acgcagctca tgcccttcgg ctccctcctg gactatgtcc g                         41


<210>  22
<211>  41
<212>  DNA
<213>  Artificial

<220>
<223>  MET c.2888 Int13-Exon14 Acceptor (Exon-14 Skipping) WT IVT

<400>  22
ttaacaagct ctttctttct ctctgtttta agatctgggc a                         41


<210>  23
<211>  41
<212>  DNA
<213>  Artificial

<220>
<223>  MET c.2888 Int13-Exon14 Acceptor (Exon-14 Skipping) Mut IVT

<400>  23
ttaacaagct ctttctttct ctctgtttta agatctgggc a                         41


<210>  24
<211>  41
<212>  DNA
<213>  Artificial

<220>
<223>  MET c.3028 Exon14-Int14 Donor (Exon-14 Skipping) WT IVT

<400>  24
atttctcaga acaataaact gaaatatacc ttctggaaaa g                         41


<210>  25
<211>  41
<212>  DNA
<213>  Artificial

<220>
<223>  MET c.3028 Exon14-Int14 Donor (Exon-14 Skipping) Mut IVT

<400>  25
atttctcaga acaataaact gaaatatacc ttctggaaaa g                         41


<210>  26
<211>  41
<212>  DNA
<213>  Artificial

<220>
<223>  MET 'TAC' Y1003X (Exon-14 Skipping) WT IVT

<400>  26
gaaatggttt caaatgaatc tgtagactac cgagctactt t                         41


<210>  27
<211>  41
<212>  DNA
<213>  Artificial

<220>
<223>  MET 'TAC' Y1003X (Exon-14 Skipping) Mut IVT

<400>  27
gaaatggttt caaatgaatc tgtagactac cgagctactt t                         41


<210>  28
<211>  41
<212>  DNA
<213>  Artificial

<220>
<223>  EGFR (L718Q) WT IVT

<400>  28
gaattcaaaa agatcaaagt gctgggctcc ggtgcgttcg g                         41


<210>  29
<211>  41
<212>  DNA
<213>  Artificial

<220>
<223>  EGFR (L718Q) Mut IVT

<400>  29
gaattcaaaa agatcaaagt gcagggctcc ggtgcgttcg g                         41


<210>  30
<211>  45
<212>  DNA
<213>  Artificial

<220>
<223>  KRAS (c.35G) WT IVT

<400>  30
tgactgaata taaacttgtg gtagttggag ctggtggcgt aggca                     45


<210>  31
<211>  45
<212>  DNA
<213>  Artificial

<220>
<223>  KRAS (c.35G) Mut IVT

<400>  31
tgactgaata taaacttgtg gtagttggag ctgctggcgt aggca                     45


<210>  32
<211>  46
<212>  DNA
<213>  Artificial

<220>
<223>  EGFR, 15bp Del p.(E746_A750) WT IVT

<400>  32
aagttaaaat tcccgtcgct atcaaggaat taagagaagc aacatc                    46


<210>  33
<211>  46
<212>  DNA
<213>  Artificial

<220>
<223>  EGFR, 15bp Del p.(E746_A750) Mut IVT

<400>  33
aagttaaaat tcccgtcgct atcaaggaat taagagaagc aacatc                    46


<210>  34
<211>  41
<212>  DNA
<213>  Artificial

<220>
<223>  EGFR (p.L858R) WT IVT

<400>  34
gatcacagat tttgggctgg ccaaactgct gggtgcggaa g                         41


<210>  35
<211>  41
<212>  DNA
<213>  Artificial

<220>
<223>  EGFR (p.L858R) Mut IVT

<400>  35
gatcacagat tttgggcggg ccaaactgct gggtgcggaa g                         41


<210>  36
<211>  39
<212>  DNA
<213>  Artificial

<220>
<223>  PIK3CA p.E542K or c.1624G>A WT IVT

<400>  36
cacgagatcc tctctctgaa atcactgagc aggagaaag                            39


<210>  37
<211>  39
<212>  DNA
<213>  Artificial

<220>
<223>  PIK3CA p.E542K or c.1624G>A Mut IVT

<400>  37
cacgagatcc tctctctaaa atcactgagc aggagaaag                            39


<210>  38
<211>  39
<212>  DNA
<213>  Artificial

<220>
<223>  PIK3CA p.E545? or c.1633G>? WT IVT

<400>  38
cacgagatcc tctctctgaa atcactgagc aggagaaag                            39


<210>  39
<211>  39
<212>  DNA
<213>  Artificial

<220>
<223>  PIK3CA p.E545? or c.1633G>? Mut IVT

<400>  39
cacgagatcc tctctctgaa atcactaagc aggagaaag                            39


<210>  40
<211>  37
<212>  DNA
<213>  Artificial

<220>
<223>  PIK3CA p.H1047? or c.3140A>? WT IVT

<400>  40
catgaaacaa atgaatgatg cacatcatgg tggctgg                              37


<210>  41
<211>  37
<212>  DNA
<213>  Artificial

<220>
<223>  PIK3CA p.H1047? or c.3140A>? Mut IVT

<400>  41
catgaaacaa atgaatgatg cacgtcatgg tggctgg                              37


<210>  42
<211>  39
<212>  DNA
<213>  Artificial

<220>
<223>  BRAF p.V600E or c.1799T>A WT IVT

<400>  42
gattttggtc tagctacagt gaaatctcga tggagtggg                            39


<210>  43
<211>  39
<212>  DNA
<213>  Artificial

<220>
<223>  BRAF p.V600E or c.1799T>A Mut IVT

<400>  43
gattttggtc tagctacaga gaaatctcga tggagtggg                            39


