                         SEQUENCE LISTING

<110>  AKOUOS, INC.
 
<120>  GENE THERAPY DELIVERY COMPOSITIONS AND METHODS FOR TREATING 
       HEARING LOSS

<130>  4833.008PC03

<150>  US 63/277,549
<151>  2021-11-09

<150>  US 63/251,025
<151>  2021-09-30

<150>  US 63/188,450
<151>  2021-05-13

<160>  129   

<170>  PatentIn version 3.5

<210>  1
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary mRNA destabilizing domain sequence

<400>  1
tccacatgga gttgctgtta ca                                                22


<210>  2
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary mRNA destabilizing domain sequence

<400>  2
ccgtggttct accctgtggt a                                                 21


<210>  3
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary mRNA destabilizing domain sequence

<400>  3
ctatctgcac tagatgcacc tta                                               23


<210>  4
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary mRNA destabilizing domain sequence

<400>  4
cacaagatcg gatctacggg tt                                                22


<210>  5
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary mRNA destabilizing domain sequence

<400>  5
ctgagtgtag gatgtttaca                                                   20


<210>  6
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary mRNA destabilizing domain sequence

<400>  6
cacaaaccat tatgtgctgc ta                                                22


<210>  7
<211>  6915
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary construct sequence

<400>  7
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggccgcac gcgtggttgt acaggagata gtcagggaat tagtaatttt      180

caaagaggtg actttgaatt caaacttaaa tatcatcttc agctgaaaca aagaaggggt      240

gcagttatga ggaagtgacc aggtaaagca tggcaaacaa aggtaaagtt tgttatgcgt      300

atttaagtca gagccctctc cattgataag agtttccagt aatttagtgc catccttttc      360

ttgctataga gttctcgtct ctatctgagc acgcaaaaat aacatgcttt cttgctttct      420

tgaagttggg catggccatt gacttgcctt agcccatatt tttctgtgaa gtggtcttca      480

aaaacctata tttctgccat agagtcactt acttaacctg ccctatttaa aggggctaat      540

gcctgataga atgtcgctgc ataactccat ctgtgtgtgg tccctgcatc catgacaacc      600

aaaacccaga tgcagaaatt gttcctaatc acatagatta ccctagaaac cggaagggcc      660

ttgaagtcaa aagcattcag agaacatgct gaacaaattg aatttgcagt ttatctggcc      720

agggaggatg gagaggggat gggcacttgg tctgagtatt ttttgtttct cattccaaca      780

gaaattacta gatttaccaa aaaatctaca agtggtagtg tgatagagtc aggcagagga      840

attgaccata gataaggtgc tcaggactcc tagagtcagc ttctggtatg tgagaaagaa      900

gtgagaacag agcccatggc atatgaagaa gatattacag aaaaaagaaa gctgccttcc      960

acgcaaatca tttctttaca aaggcttgtt aactcctgca gtgccaagaa gctgaatgca     1020

gcggcagaca tcctggttcg ggccccagga agctcagccg ggtttaatgt ggatgagggt     1080

ttaatgatgt acacgcagaa gtgttttgac aaatgaagaa ggtcctcatt cttggaacat     1140

gtgccggttc tccgagggaa ctcctaaaag gctgtaagct catgtaggaa aagctgagct     1200

agattcctaa gggcagagat gtgctcacat ttctttgcat ccctagttcc cagcacagtg     1260

caaggcgctg caaacatttg ctgaacccag ggtctcgtgt cttgactgtc cagcagaggc     1320

cgctctgggc cggggctctc gggacctgag ggctgagaga aggaaggcca gggggtggcc     1380

cagtcatcgc cgcggggccc gggtgggagg ggtttggcag cggcaggcgc ggcggcggcg     1440

gcggaggcgg aggcggcccc gggaagctct gaggacccag aggccgggcg cgctccgccc     1500

gcggcgccgc cccctccgta actttcccag tctccgaggg aagaggcggg gtgtggggtg     1560

cggttaaaag gcgccacggc gggagacagg tctcaccggt gcaaactggt tgcggccccg     1620

cagcgcccgc gcgctcctct ccccgactcg gagcccctcg gcggcgcccg gcccaggacc     1680

cgcctaggag cgcaggagcc ccagcgcaga gaccccaacg ccgagacccc cgccccggcc     1740

ccgccgcgct tcctcccgac gcagtttagg acccttgttc gcgaagaggt ggtgtgcggc     1800

tgagacccgc gtcctcagga cggttccatc agtgcctcga tcctgcccca ctggaggagg     1860

aaggcagccc gaacagcgct cacctaacta acagctgctg agagctgggt tccgtggcca     1920

tgcacctggg actgccttga gaagcgtgag caaaccgccc agagtagaag cgctagccac     1980

catggattgg ggcacgctgc agacgatcct ggggggtgtg aacaaacact ccaccagcat     2040

tggaaagatc tggctcaccg tcctcttcat ttttcgcatt atgatcctcg ttgtggctgc     2100

aaaggaggtg tggggagatg agcaggccga ctttgtctgc aacaccctgc agccaggctg     2160

caagaacgtg tgctacgatc actacttccc catctcccac atccggctat gggccctgca     2220

gctgatcttc gtgtccacgc cagcgctcct agtggccatg cacgtggcct accggagaca     2280

tgagaagaag aggaagttca tcaaggggga gataaagagt gaatttaagg acatcgagga     2340

gatcaaaacc cagaaggtcc gcatcgaagg ctccctgtgg tggacctaca caagcagcat     2400

cttcttccgg gtcatcttcg aagccgcctt catgtacgtc ttctatgtca tgtacgacgg     2460

cttctccatg cagcggctgg tgaagtgcaa cgcctggcct tgtcccaaca ctgtggactg     2520

ctttgtgtcc cggcccacgg agaagactgt cttcacagtg ttcatgattg cagtgtctgg     2580

aatttgcatc ctgctgaatg tcactgaatt gtgttatttg ctaattagat attgttctgg     2640

gaagtcaaaa aagccagttg gatcccgggc tgactacaaa gaccatgacg gtgattataa     2700

agatcatgac atcgactaca aggatgacga tgacaagtaa gaaatagaca gcatgagagg     2760

gatgaggcaa cccgtgctca gctgtcaagg ctcagtcgct agcatttccc aacacaaaga     2820

ttctgacctt aaatgcaacc atttgaaacc cctgtaggcc tcaggtgaaa ctccagatgc     2880

cacaatggag ctctgctccc ctaaagcctc aaaacaaagg cctaattcta tgcctgtctt     2940

aattttcttt cacttaagtt agttccactg agaccccagg ctgttagggg ttattggtgt     3000

aaggtacttt catattttaa acagaggata tcggcatttg tttctttctc tgaggacaag     3060

agaaaaaagc caggttccac agaggacaca gagaaggttt gggtgtcctc ctggggttct     3120

ttttgccaac tttccccacg ttaaaggtga acattggttc tttcatttgc tttggaagtt     3180

ttaatctcta acagtggaca aagttaccag tgccttaaac tctgttacac tttttggaag     3240

tgaaaacttt gtagtatgat aggttatttt gatgtaaaga tgttctggat accattatat     3300

gttccccctg tttcagaggc tcagattgta atatgtaaat ggtatgtcat tcgctactat     3360

gatttaattt gaaatatggt cttttggtta tgaatacttt gcagcacagc tgagaggctg     3420

tctgttgtat tcattgtggt catagcacct aacaacattg tagcctcaat cgagtgagac     3480

agactagaag ttcctagtga tggcttatga tagcaaatgg cctcatgtca aatatttaga     3540

tgtaattttg tgtaagaaat acagactgga tgtaccacca actactacct gtaatgacag     3600

gcctgtccaa cacatctccc ttttccatga ctgtggtagc cagcatcgga aagaacgctg     3660

atttaaagag gtcgcttggg aattttattg acacagtacc atttaatggg gaggacaaaa     3720

tggggcaggg gagggagaag tttctgtcgt taaaaacaga tttggaaaga ctggactcta     3780

aagtctgttg attaaagatg agctttgtct acttcaaaag tttgtttgct taccccttca     3840

gcctccaatt ttttaagtga aaatatagct aataacatgt gaaaagaata gaagctaagg     3900

tttagataaa tattgagcag atctatagga agattgaacc tgaatattgc cattatgctt     3960

gacatggttt ccaaaaaatg gtactccaca tatttcagtg agggtaagta ttttcctgtt     4020

gtcaagaata gcattgtaaa agcattttgt aataataaag aatagcttta atgatatgct     4080

tgtaactaaa ataattttgt aatgtatcaa atacatttaa aacattaaaa tataatctct     4140

ataataagag ctcgctgatc agcctcgact gtgccttcta gttgccagcc atctgttgtt     4200

tgcccctccc ccgtgccttc cttgaccctg gaaggtgcca ctcccactgt cctttcctaa     4260

taaaatgagg aaattgcatc gcattgtctg agtaggtgtc attctattct ggggggtggg     4320

gtggggcagg acagcaaggg ggaggattgg gaagacaata gcaggcatgc tggggatgcg     4380

gtgggctcta tggaagcttg aattcagctg acgtgcctcg gaccgctagg aacccctagt     4440

gatggagttg gccactccct ctctgcgcgc tcgctcgctc actgaggccg ggcgaccaaa     4500

ggtcgcccga cgcccgggct ttgcccgggc ggcctcagtg agcgagcgag cgcgcagctg     4560

cctgcagggg cgcctgatgc ggtattttct ccttacgcat ctgtgcggta tttcacaccg     4620

catacgtcaa agcaaccata gtacgcgccc tgtagcggcg cattaagcgc ggcgggtgtg     4680

gtggttacgc gcagcgtgac cgctacactt gccagcgccc tagcgcccgc tcctttcgct     4740

ttcttccctt cctttctcgc cacgttcgcc ggctttcccc gtcaagctct aaatcggggg     4800

ctccctttag ggttccgatt tagtgcttta cggcacctcg accccaaaaa acttgatttg     4860

ggtgatggtt cacgtagtgg gccatcgccc tgatagacgg tttttcgccc tttgacgttg     4920

gagtccacgt tctttaatag tggactcttg ttccaaactg gaacaacact caaccctatc     4980

tcgggctatt cttttgattt ataagggatt ttgccgattt cggcctattg gttaaaaaat     5040

gagctgattt aacaaaaatt taacgcgaat tttaacaaaa tattaacgtt tacaatttta     5100

tggtgcactc tcagtacaat ctgctctgat gccgcatagt taagccagcc ccgacacccg     5160

ccaacacccg ctgacgcgcc ctgacgggct tgtctgctcc cggcatccgc ttacagacaa     5220

gctgtgaccg tctccgggag ctgcatgtgt cagaggtttt caccgtcatc accgaaacgc     5280

gcgagacgaa agggcctcgt gatacgccta tttttatagg ttaatgtcat gaacaataaa     5340

actgtctgct tacataaaca gtaatacaag gggtgttatg agccatattc aacgggaaac     5400

gtcgaggccg cgattaaatt ccaacatgga tgctgattta tatgggtata aatgggctcg     5460

cgataatgtc gggcaatcag gtgcgacaat ctatcgcttg tatgggaagc ccgatgcgcc     5520

agagttgttt ctgaaacatg gcaaaggtag cgttgccaat gatgttacag atgagatggt     5580

cagactaaac tggctgacgg aatttatgcc tcttccgacc atcaagcatt ttatccgtac     5640

tcctgatgat gcatggttac tcaccactgc gatccccgga aaaacagcat tccaggtatt     5700

agaagaatat cctgattcag gtgaaaatat tgttgatgcg ctggcagtgt tcctgcgccg     5760

gttgcattcg attcctgttt gtaattgtcc ttttaacagc gatcgcgtat ttcgtctcgc     5820

tcaggcgcaa tcacgaatga ataacggttt ggttgatgcg agtgattttg atgacgagcg     5880

taatggctgg cctgttgaac aagtctggaa agaaatgcat aaacttttgc cattctcacc     5940

ggattcagtc gtcactcatg gtgatttctc acttgataac cttatttttg acgaggggaa     6000

attaataggt tgtattgatg ttggacgagt cggaatcgca gaccgatacc aggatcttgc     6060

catcctatgg aactgcctcg gtgagttttc tccttcatta cagaaacggc tttttcaaaa     6120

atatggtatt gataatcctg atatgaataa attgcagttt catttgatgc tcgatgagtt     6180

tttctaatct catgaccaaa atcccttaac gtgagttttc gttccactga gcgtcagacc     6240

ccgtagaaaa gatcaaagga tcttcttgag atcctttttt tctgcgcgta atctgctgct     6300

tgcaaacaaa aaaaccaccg ctaccagcgg tggtttgttt gccggatcaa gagctaccaa     6360

ctctttttcc gaaggtaact ggcttcagca gagcgcagat accaaatact gtccttctag     6420

tgtagccgta gttaggccac cacttcaaga actctgtagc accgcctaca tacctcgctc     6480

tgctaatcct gttaccagtg gctgctgcca gtggcgataa gtcgtgtctt accgggttgg     6540

actcaagacg atagttaccg gataaggcgc agcggtcggg ctgaacgggg ggttcgtgca     6600

cacagcccag cttggagcga acgacctaca ccgaactgag atacctacag cgtgagctat     6660

gagaaagcgc cacgcttccc gaagggagaa aggcggacag gtatccggta agcggcaggg     6720

tcggaacagg agagcgcacg agggagcttc cagggggaaa cgcctggtat ctttatagtc     6780

ctgtcgggtt tcgccacctc tgacttgagc gtcgattttt gtgatgctcg tcaggggggc     6840

ggagcctatg gaaaaacgcc agcaacgcgg cctttttacg gttcctggcc ttttgctggc     6900

cttttgctca catgt                                                      6915


<210>  8
<211>  145
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary 5' AAV ITR

<400>  8
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgcccgggc aaagcccggg       60

cgtcgggcga cctttggtcg cccggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcct                                            145


<210>  9
<211>  145
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary 3' AAV ITR

<400>  9
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg       60

ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc      120

gagcgcgcag agagggagtg gccaa                                            145


<210>  10
<211>  277
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary CBA promoter

<400>  10
gtcgaggtga gccccacgtt ctgcttcact ctccccatct cccccccctc cccaccccca       60

attttgtatt tatttatttt ttaattattt tgtgcagcga tgggggcggg gggggggggg      120

gcgcgcgcca ggcggggcgg ggcggggcga ggggcggggc ggggcgaggc ggagaggtgc      180

ggcggcagcc aatcagagcg gcgcgctccg aaagtttcct tttatggcga ggcggcggcg      240

gcggcggccc tataaaaagc gaagcgcgcg gcgggcg                               277


<210>  11
<211>  279
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary CBA promoter

<400>  11
gtcgaggtga gccccacgtt ctgcttcact ctccccatct cccccccctc cccaccccca       60

attttgtatt tatttatttt ttaattattt tgtgcagcga tgggggcggg gggggggggg      120

gggcgcgcgc caggcggggc ggggcggggc gaggggcggg gcggggcgag gcggagaggt      180

gcggcggcag ccaatcagag cggcgcgctc cgaaagtttc cttttatggc gaggcggcgg      240

cggcggcggc cctataaaaa gcgaagcgcg cggcgggcg                             279


<210>  12
<211>  658
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary CMV/CBA enhancer/promoter

<400>  12
gacattgatt attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc       60

catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca      120

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga      180

ctttccattg acgtcaatgg gtggactatt tacggtaaac tgcccacttg gcagtacatc      240

aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct      300

ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat      360

tagtcatcgc tattaccatg ggtcgaggtg agccccacgt tctgcttcac tctccccatc      420

tcccccccct ccccaccccc aattttgtat ttatttattt tttaattatt ttgtgcagcg      480

atgggggcgg gggggggggg ggcgcgcgcc aggcggggcg gggcggggcg aggggcgggg      540

cggggcgagg cggagaggtg cggcggcagc caatcagagc ggcgcgctcc gaaagtttcc      600

ttttatggcg aggcggcggc ggcggcggcc ctataaaaag cgaagcgcgc ggcgggcg        658


<210>  13
<211>  660
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary CMV/CBA enhancer/promoter

<400>  13
gacattgatt attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc       60

catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca      120

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga      180

ctttccattg acgtcaatgg gtggactatt tacggtaaac tgcccacttg gcagtacatc      240

aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct      300

ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat      360

tagtcatcgc tattaccatg ggtcgaggtg agccccacgt tctgcttcac tctccccatc      420

tcccccccct ccccaccccc aattttgtat ttatttattt tttaattatt ttgtgcagcg      480

atgggggcgg gggggggggg ggggcgcgcg ccaggcgggg cggggcgggg cgaggggcgg      540

ggcggggcga ggcggagagg tgcggcggca gccaatcaga gcggcgcgct ccgaaagttt      600

ccttttatgg cgaggcggcg gcggcggcgg ccctataaaa agcgaagcgc gcggcgggcg      660


<210>  14
<211>  1671
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary CAG enhancer/promoter

<400>  14
gacattgatt attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc       60

catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca      120

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga      180

ctttccattg acgtcaatgg gtggactatt tacggtaaac tgcccacttg gcagtacatc      240

aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct      300

ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat      360

tagtcatcgc tattaccatg ggtcgaggtg agccccacgt tctgcttcac tctccccatc      420

tcccccccct ccccaccccc aattttgtat ttatttattt tttaattatt ttgtgcagcg      480

atgggggcgg gggggggggg ggcgcgcgcc aggcggggcg gggcggggcg aggggcgggg      540

cggggcgagg cggagaggtg cggcggcagc caatcagagc ggcgcgctcc gaaagtttcc      600

ttttatggcg aggcggcggc ggcggcggcc ctataaaaag cgaagcgcgc ggcgggcggg      660

agtcgctgcg ttgccttcgc cccgtgcccc gctccgcgcc gcctcgcgcc gcccgccccg      720

gctctgactg accgcgttac tcccacaggt gagcgggcgg gacggccctt ctcctccggg      780

ctgtaattag cgcttggttt aatgacggct cgtttctttt ctgtggctgc gtgaaagcct      840

taaagggctc cgggagggcc ctttgtgcgg gggggagcgg ctcggggggt gcgtgcgtgt      900

gtgtgtgcgt ggggagcgcc gcgtgcggcc cgcgctgccc ggcggctgtg agcgctgcgg      960

gcgcggcgcg gggctttgtg cgctccgcgt gtgcgcgagg ggagcgcggc cgggggcggt     1020

gccccgcggt gcgggggggc tgcgagggga acaaaggctg cgtgcggggt gtgtgcgtgg     1080

gggggtgagc agggggtgtg ggcgcggcgg tcgggctgta acccccccct gcacccccct     1140

ccccgagttg ctgagcacgg cccggcttcg ggtgcggggc tccgtgcggg gcgtggcgcg     1200

gggctcgccg tgccgggcgg ggggtggcgg caggtggggg tgccgggcgg ggcggggccg     1260

cctcgggccg gggagggctc gggggagggg cgcggcggcc cccggagcgc cggcggctgt     1320

cgaggcgcgg cgagccgcag ccattgcctt ttatggtaat cgtgcgagag ggcgcaggga     1380

cttcctttgt cccaaatctg tgcggagccg aaatctggga ggcgccgccg caccccctct     1440

agcgggcgcg gggcgaagcg gtgcggcgcc ggcaggaagg aaatgggcgg ggagggcctt     1500

cgtgcgtcgc cgcgccgccg tccccttctc cctctccagc ctcggggctg tccgcggggg     1560

gacggctgcc ttcggggggg acggggcagg gcggggttcg gcttctggcg tgtgaccggc     1620

ggctctagag cctctgctaa ccatgttcat gccttcttct ttttcctaca g              1671


<210>  15
<211>  1673
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary CAG enhancer/promoter

<400>  15
gacattgatt attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc       60

catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca      120

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga      180

ctttccattg acgtcaatgg gtggactatt tacggtaaac tgcccacttg gcagtacatc      240

aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct      300

ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat      360

tagtcatcgc tattaccatg ggtcgaggtg agccccacgt tctgcttcac tctccccatc      420

tcccccccct ccccaccccc aattttgtat ttatttattt tttaattatt ttgtgcagcg      480

atgggggcgg gggggggggg ggggcgcgcg ccaggcgggg cggggcgggg cgaggggcgg      540

ggcggggcga ggcggagagg tgcggcggca gccaatcaga gcggcgcgct ccgaaagttt      600

ccttttatgg cgaggcggcg gcggcggcgg ccctataaaa agcgaagcgc gcggcgggcg      660

ggagtcgctg cgttgccttc gccccgtgcc ccgctccgcg ccgcctcgcg ccgcccgccc      720

cggctctgac tgaccgcgtt actcccacag gtgagcgggc gggacggccc ttctcctccg      780

ggctgtaatt agcgcttggt ttaatgacgg ctcgtttctt ttctgtggct gcgtgaaagc      840

cttaaagggc tccgggaggg ccctttgtgc gggggggagc ggctcggggg gtgcgtgcgt      900

gtgtgtgtgc gtggggagcg ccgcgtgcgg cccgcgctgc ccggcggctg tgagcgctgc      960

gggcgcggcg cggggctttg tgcgctccgc gtgtgcgcga ggggagcgcg gccgggggcg     1020

gtgccccgcg gtgcgggggg gctgcgaggg gaacaaaggc tgcgtgcggg gtgtgtgcgt     1080

gggggggtga gcagggggtg tgggcgcggc ggtcgggctg taaccccccc ctgcaccccc     1140

ctccccgagt tgctgagcac ggcccggctt cgggtgcggg gctccgtgcg gggcgtggcg     1200

cggggctcgc cgtgccgggc ggggggtggc ggcaggtggg ggtgccgggc ggggcggggc     1260

cgcctcgggc cggggagggc tcgggggagg ggcgcggcgg cccccggagc gccggcggct     1320

gtcgaggcgc ggcgagccgc agccattgcc ttttatggta atcgtgcgag agggcgcagg     1380

gacttccttt gtcccaaatc tgtgcggagc cgaaatctgg gaggcgccgc cgcaccccct     1440

ctagcgggcg cggggcgaag cggtgcggcg ccggcaggaa ggaaatgggc ggggagggcc     1500

ttcgtgcgtc gccgcgccgc cgtccccttc tccctctcca gcctcggggc tgtccgcggg     1560

gggacggctg ccttcggggg ggacggggca gggcggggtt cggcttctgg cgtgtgaccg     1620

gcggctctag agcctctgct aaccatgttc atgccttctt ctttttccta cag            1673


<210>  16
<211>  735
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GJB6 promoter

<400>  16
aaatagcttc caacgtttcc accccaccag cccttgcacc actccctgta ctggccctga       60

gctttctagt cttgactgaa aagcggggag gcaatgtggt ctctcctggt gcactgtccc      120

gaggaaggcc tgctccgctt ccccggagga gtcttcaaag gatggaggta attaataaaa      180

acaacccctg tacctcctct aagtggtcat taattaataa agaacctcca ggctcctata      240

ggagaggtct gtgcaccccg cgggctatga gaaggctgga tcacccagaa agactgagga      300

tgtgtcctgg caaaaacaca gcctgcccct cacactgctc cccacgggtg cactagggag      360

gaagagttcc ctcgagggcc tgagcaggcg ccccacacct gcacccgtgc agagggggct      420

gggcccgccc tctgcgctcc cgagggagag ccctaccccc tgcatccccg gtaccccgtt      480

ccctccaagg gccggaaaga gggccccgcg cactgtgcac ttcttagggg tcccccaccc      540

tgcgcccccg ccacgggaaa aaggtccccg ctctgcgcat ccggccccgg agggacagcc      600

ccggtcctgc actccttgct cctcaggggg acggtccgcg cccagcggct agtgcgcccc      660

gggtaggtgg gggcgggggg ctcgtcgagt gacagcgctc gcctcccgca gcccgcccga      720

gccgcgtcag ggcag                                                       735


<210>  17
<211>  6696
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary Construct Sequence

<400>  17
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggccgcac gcgtggtccc atggctctgt taaaatcaaa gaaacatctt      180

ttccaacagc cctttcaaac tcctcatcgc atctcactgg ctgattcagt catttaaacc      240

tgcttctccc taaagctgat cactggctaa gctaataggg tttccgggat tggtttagcc      300

tgatactaat ccaggtctac cttcaggagc cagaccaaac tgcctattgg cattgcattc      360

ttgcagtagg gaggggaggt atggatggtg tggagtccac cacaaggtcc atgccagtct      420

ttgctgaacc agcatcagac tccatcaagc aacagatgag aggttccatg ataaagtggc      480

cctcagcaat ccccatccat tgctgtctag gaagaacagt gcttgtacac aggtttagga      540

cctcagtctt ggctgtaatc ttctggttta ctttgccagc accaaacaga aggaaagaaa      600

gggctcaaat ttgaccaaat aaattatgct tctccttcca gagataacct tgagtcctgt      660

ctaggaagat attagaattg taaagaaaaa aaaaattact ccttatccta tggcaagtgg      720

agtctatgtc tacttcagct gaaattaaat cctgtccata atagatgacc cttgctcaag      780

ctggccagaa gccataccaa ccagcacgaa ggttaaaact attattagtt ttttctgtga      840

ttttcatttt caggccaagt tttagaacaa taagatttta agaataggaa gtaagtaaga      900

tttctgcata tcctgttctc ttagtcagct gaattttttt tttttttttt ttagtcctaa      960

ctcagcctcc caaagtgctg ggattacagg cgtgagccac cgcaccaagc ctggaatcta     1020

tgtcttacag ttatgagaat caacagctag ctcattatgg gcaaggtgat gtcactctgg     1080

cttctcaatg aaaatggcat ttctcccttg gaaaaggtca tagccagtca gtcagtcagt     1140

cacgggagcg cagcggcttc taggggtgag tgggacccac gcggccccac ctgctcctcc     1200

cgcgcgcggc cccacccccc tgccccgccc cgcctggttt atagaagctc tgaggaccca     1260

gaggccgggc gcgctccgcc cgcggcgccg ccccctccgt aactttccca gtctccgagg     1320

gaagaggcgg ggtgtggggt gcggttaaaa ggcgccacgg cgggagacag gtctcaccgg     1380

tcgtgtgttg ttgcggcccc gcagcgcccg cgcgctcctc tccccgactc ggagcccctc     1440

ggcggcgccc ggcccaggac ccgcctagga gcgcaggagc cccagcgcag agaccccaac     1500

gccgagaccc ccgccccggc cccgccgcgc ttcctcccga cgcagtttag gacccttgtt     1560

cgcgaagagg tggtgtgcgg ctgagacccg cgtcctcagg acggttccat cagtgcctcg     1620

atcctgcccc actggaggag gaaggcagcc cgaacagcgc tcacctaact aacagctgct     1680

gagagctggg ttccgtggcc atgcacctgg gactgccttg agaagcgtga gcaaaccgcc     1740

cagagtagaa gcgctagcca ccatggattg gggcacgctg cagacgatcc tggggggtgt     1800

gaacaaacac tccaccagca ttggaaagat ctggctcacc gtcctcttca tttttcgcat     1860

tatgatcctc gttgtggctg caaaggaggt gtggggagat gagcaggccg actttgtctg     1920

caacaccctg cagccaggct gcaagaacgt gtgctacgat cactacttcc ccatctccca     1980

catccggcta tgggccctgc agctgatctt cgtgtccacg ccagcgctcc tagtggccat     2040

gcacgtggcc taccggagac atgagaagaa gaggaagttc atcaaggggg agataaagag     2100

tgaatttaag gacatcgagg agatcaaaac ccagaaggtc cgcatcgaag gctccctgtg     2160

gtggacctac acaagcagca tcttcttccg ggtcatcttc gaagccgcct tcatgtacgt     2220

cttctatgtc atgtacgacg gcttctccat gcagcggctg gtgaagtgca acgcctggcc     2280

ttgtcccaac actgtggact gctttgtgtc ccggcccacg gagaagactg tcttcacagt     2340

gttcatgatt gcagtgtctg gaatttgcat cctgctgaat gtcactgaat tgtgttattt     2400

gctaattaga tattgttctg ggaagtcaaa aaagccagtt ggatcccggg ctgactacaa     2460

agaccatgac ggtgattata aagatcatga catcgactac aaggatgacg atgacaagta     2520

agaaatagac agcatgagag ggatgaggca acccgtgctc agctgtcaag gctcagtcgc     2580

tagcatttcc caacacaaag attctgacct taaatgcaac catttgaaac ccctgtaggc     2640

ctcaggtgaa actccagatg ccacaatgga gctctgctcc cctaaagcct caaaacaaag     2700

gcctaattct atgcctgtct taattttctt tcacttaagt tagttccact gagaccccag     2760

gctgttaggg gttattggtg taaggtactt tcatatttta aacagaggat atcggcattt     2820

gtttctttct ctgaggacaa gagaaaaaag ccaggttcca cagaggacac agagaaggtt     2880

tgggtgtcct cctggggttc tttttgccaa ctttccccac gttaaaggtg aacattggtt     2940

ctttcatttg ctttggaagt tttaatctct aacagtggac aaagttacca gtgccttaaa     3000

ctctgttaca ctttttggaa gtgaaaactt tgtagtatga taggttattt tgatgtaaag     3060

atgttctgga taccattata tgttccccct gtttcagagg ctcagattgt aatatgtaaa     3120

tggtatgtca ttcgctacta tgatttaatt tgaaatatgg tcttttggtt atgaatactt     3180

tgcagcacag ctgagaggct gtctgttgta ttcattgtgg tcatagcacc taacaacatt     3240

gtagcctcaa tcgagtgaga cagactagaa gttcctagtg atggcttatg atagcaaatg     3300

gcctcatgtc aaatatttag atgtaatttt gtgtaagaaa tacagactgg atgtaccacc     3360

aactactacc tgtaatgaca ggcctgtcca acacatctcc cttttccatg actgtggtag     3420

ccagcatcgg aaagaacgct gatttaaaga ggtcgcttgg gaattttatt gacacagtac     3480

catttaatgg ggaggacaaa atggggcagg ggagggagaa gtttctgtcg ttaaaaacag     3540

atttggaaag actggactct aaagtctgtt gattaaagat gagctttgtc tacttcaaaa     3600

gtttgtttgc ttaccccttc agcctccaat tttttaagtg aaaatatagc taataacatg     3660

tgaaaagaat agaagctaag gtttagataa atattgagca gatctatagg aagattgaac     3720

ctgaatattg ccattatgct tgacatggtt tccaaaaaat ggtactccac atatttcagt     3780

gagggtaagt attttcctgt tgtcaagaat agcattgtaa aagcattttg taataataaa     3840

gaatagcttt aatgatatgc ttgtaactaa aataattttg taatgtatca aatacattta     3900

aaacattaaa atataatctc tataataaga gctcgctgat cagcctcgac tgtgccttct     3960

agttgccagc catctgttgt ttgcccctcc cccgtgcctt ccttgaccct ggaaggtgcc     4020

actcccactg tcctttccta ataaaatgag gaaattgcat cgcattgtct gagtaggtgt     4080

cattctattc tggggggtgg ggtggggcag gacagcaagg gggaggattg ggaagacaat     4140

agcaggcatg ctggggatgc ggtgggctct atggaagctt gaattcagct gacgtgcctc     4200

ggaccgctag gaacccctag tgatggagtt ggccactccc tctctgcgcg ctcgctcgct     4260

cactgaggcc gggcgaccaa aggtcgcccg acgcccgggc tttgcccggg cggcctcagt     4320

gagcgagcga gcgcgcagct gcctgcaggg gcgcctgatg cggtattttc tccttacgca     4380

tctgtgcggt atttcacacc gcatacgtca aagcaaccat agtacgcgcc ctgtagcggc     4440

gcattaagcg cggcgggtgt ggtggttacg cgcagcgtga ccgctacact tgccagcgcc     4500

ctagcgcccg ctcctttcgc tttcttccct tcctttctcg ccacgttcgc cggctttccc     4560

cgtcaagctc taaatcgggg gctcccttta gggttccgat ttagtgcttt acggcacctc     4620

gaccccaaaa aacttgattt gggtgatggt tcacgtagtg ggccatcgcc ctgatagacg     4680

gtttttcgcc ctttgacgtt ggagtccacg ttctttaata gtggactctt gttccaaact     4740

ggaacaacac tcaaccctat ctcgggctat tcttttgatt tataagggat tttgccgatt     4800

tcggcctatt ggttaaaaaa tgagctgatt taacaaaaat ttaacgcgaa ttttaacaaa     4860

atattaacgt ttacaatttt atggtgcact ctcagtacaa tctgctctga tgccgcatag     4920

ttaagccagc cccgacaccc gccaacaccc gctgacgcgc cctgacgggc ttgtctgctc     4980

ccggcatccg cttacagaca agctgtgacc gtctccggga gctgcatgtg tcagaggttt     5040

tcaccgtcat caccgaaacg cgcgagacga aagggcctcg tgatacgcct atttttatag     5100

gttaatgtca tgaacaataa aactgtctgc ttacataaac agtaatacaa ggggtgttat     5160

gagccatatt caacgggaaa cgtcgaggcc gcgattaaat tccaacatgg atgctgattt     5220

atatgggtat aaatgggctc gcgataatgt cgggcaatca ggtgcgacaa tctatcgctt     5280

gtatgggaag cccgatgcgc cagagttgtt tctgaaacat ggcaaaggta gcgttgccaa     5340

tgatgttaca gatgagatgg tcagactaaa ctggctgacg gaatttatgc ctcttccgac     5400

catcaagcat tttatccgta ctcctgatga tgcatggtta ctcaccactg cgatccccgg     5460

aaaaacagca ttccaggtat tagaagaata tcctgattca ggtgaaaata ttgttgatgc     5520

gctggcagtg ttcctgcgcc ggttgcattc gattcctgtt tgtaattgtc cttttaacag     5580

cgatcgcgta tttcgtctcg ctcaggcgca atcacgaatg aataacggtt tggttgatgc     5640

gagtgatttt gatgacgagc gtaatggctg gcctgttgaa caagtctgga aagaaatgca     5700

taaacttttg ccattctcac cggattcagt cgtcactcat ggtgatttct cacttgataa     5760

ccttattttt gacgagggga aattaatagg ttgtattgat gttggacgag tcggaatcgc     5820

agaccgatac caggatcttg ccatcctatg gaactgcctc ggtgagtttt ctccttcatt     5880

acagaaacgg ctttttcaaa aatatggtat tgataatcct gatatgaata aattgcagtt     5940

tcatttgatg ctcgatgagt ttttctaatc tcatgaccaa aatcccttaa cgtgagtttt     6000

cgttccactg agcgtcagac cccgtagaaa agatcaaagg atcttcttga gatccttttt     6060

ttctgcgcgt aatctgctgc ttgcaaacaa aaaaaccacc gctaccagcg gtggtttgtt     6120

tgccggatca agagctacca actctttttc cgaaggtaac tggcttcagc agagcgcaga     6180

taccaaatac tgtccttcta gtgtagccgt agttaggcca ccacttcaag aactctgtag     6240

caccgcctac atacctcgct ctgctaatcc tgttaccagt ggctgctgcc agtggcgata     6300

agtcgtgtct taccgggttg gactcaagac gatagttacc ggataaggcg cagcggtcgg     6360

gctgaacggg gggttcgtgc acacagccca gcttggagcg aacgacctac accgaactga     6420

gatacctaca gcgtgagcta tgagaaagcg ccacgcttcc cgaagggaga aaggcggaca     6480

ggtatccggt aagcggcagg gtcggaacag gagagcgcac gagggagctt ccagggggaa     6540

acgcctggta tctttatagt cctgtcgggt ttcgccacct ctgacttgag cgtcgatttt     6600

tgtgatgctc gtcagggggg cggagcctat ggaaaaacgc cagcaacgcg gcctttttac     6660

ggttcctggc cttttgctgg ccttttgctc acatgt                               6696


<210>  18
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary CMV enhancer

<400>  18
gacattgatt attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc       60

catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca      120

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga      180

ctttccattg acgtcaatgg gtggactatt tacggtaaac tgcccacttg gcagtacatc      240

aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct      300

ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat      360

tagtcatcgc tattaccatg g                                                381


<210>  19
<211>  1013
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary SV-40 synthetic intron

<400>  19
ggagtcgctg cgttgccttc gccccgtgcc ccgctccgcg ccgcctcgcg ccgcccgccc       60

cggctctgac tgaccgcgtt actcccacag gtgagcgggc gggacggccc ttctcctccg      120

ggctgtaatt agcgcttggt ttaatgacgg ctcgtttctt ttctgtggct gcgtgaaagc      180

cttaaagggc tccgggaggg ccctttgtgc gggggggagc ggctcggggg gtgcgtgcgt      240

gtgtgtgtgc gtggggagcg ccgcgtgcgg cccgcgctgc ccggcggctg tgagcgctgc      300

gggcgcggcg cggggctttg tgcgctccgc gtgtgcgcga ggggagcgcg gccgggggcg      360

gtgccccgcg gtgcgggggg gctgcgaggg gaacaaaggc tgcgtgcggg gtgtgtgcgt      420

gggggggtga gcagggggtg tgggcgcggc ggtcgggctg taaccccccc ctgcaccccc      480

ctccccgagt tgctgagcac ggcccggctt cgggtgcggg gctccgtgcg gggcgtggcg      540

cggggctcgc cgtgccgggc ggggggtggc ggcaggtggg ggtgccgggc ggggcggggc      600

cgcctcgggc cggggagggc tcgggggagg ggcgcggcgg cccccggagc gccggcggct      660

gtcgaggcgc ggcgagccgc agccattgcc ttttatggta atcgtgcgag agggcgcagg      720

gacttccttt gtcccaaatc tgtgcggagc cgaaatctgg gaggcgccgc cgcaccccct      780

ctagcgggcg cggggcgaag cggtgcggcg ccggcaggaa ggaaatgggc ggggagggcc      840

ttcgtgcgtc gccgcgccgc cgtccccttc tccctctcca gcctcggggc tgtccgcggg      900

gggacggctg ccttcggggg ggacggggca gggcggggtt cggcttctgg cgtgtgaccg      960

gcggctctag agcctctgct aaccatgttc atgccttctt ctttttccta cag            1013


<210>  20
<211>  178
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary 5' UTR Sequence

<400>  20
gttgcggccc cgcagcgccc gcgcgctcct ctccccgact cggagcccct cggcggcgcc       60

cggcccagga cccgcctagg agcgcaggag ccccagcgca gagaccccaa cgccgagacc      120

cccgccccgg ccccgccgcg cttcctcccg acgcagagca aaccgcccag agtagaag        178


<210>  21
<211>  206
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary 5' UTR Sequence

<400>  21
tttaggaccc ttgttcgcga agaggtggtg tgcggctgag acccgcgtcc tcaggacggt       60

tccatcagtg cctcgatcct gccccactgg aggaggaagg cagcccgaac agcgctcacc      120

taactaacag ctgctgagag ctgggttccg tggccatgca cctgggactg ccttgagaag      180

cgtgagcaaa ccgcccagag tagaag                                           206


<210>  22
<211>  1432
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary 3' UTR Sequence

<400>  22
cgcattgccc agttgttaga ttaagaaata gacagcatga gagggatgag gcaacccgtg       60

ctcagctgtc aaggctcagt cgctagcatt tcccaacaca aagattctga ccttaaatgc      120

aaccatttga aacccctgta ggcctcaggt gaaactccag atgccacaat ggagcctctg      180

ctcccctaaa gcctcaaaac aaaggcctaa ttctatgcct gtcttaattt tctttcactt      240

aagttagttc cactgagacc ccaggctgtt aggggttatt ggtgtaaggt actttcatat      300

tttaaacaga ggatatcggc atttgtttct ttctctgagg acaagagaaa aaagccaggt      360

tccacagagg acacagagaa ggtttgggtg tcctcctggg gttctttttg ccaactttcc      420

ccacgttaaa ggtgaacatt ggttctttca tttgctttgg aagttttaat ctctaacagt      480

ggacaaagtt accagtgcct taaactctgt tacacttttt ggaagtgaaa actttgtagt      540

atgataggtt attttgatgt aaagatgttc tggataccat tatatgttcc ccctgtttca      600

gaggctcaga ttgtaatatg taaatggtat gtcattcgct actatgattt aatttgaaat      660

atggtctttt ggttatgaat actttgcagc acagctgaga ggctgtctgt tgtattcatt      720

gtggtcatag cacctaacaa cattgtagcc tcaatcgagt gagacagact agaagttcct      780

agtgatggct tatgatagca aatggcctca tgtcaaatat ttagatgtaa ttttgtgtaa      840

gaaatacaga ctggatgtac caccaactac tacctgtaat gacaggcctg tccaacacat      900

ctcccttttc catgactgtg gtagccagca tcggaaagaa cgctgattta aagaggtcgc      960

ttgggaattt tattgacaca gtaccattta atggggagga caaaatgggg caggggaggg     1020

agaagtttct gtcgttaaaa acagatttgg aaagactgga ctctaaagtc tgttgattaa     1080

agatgagctt tgtctacttc aaaagtttgt ttgcttaccc cttcagcctc caatttttta     1140

agtgaaaata tagctaataa catgtgaaaa gaatagaagc taaggtttag ataaatattg     1200

agcagatcta taggaagatt gaacctgaat attgccatta tgcttgacat ggtttccaaa     1260

aaatggtact ccacatattt cagtgagggt aagtattttc ctgttgtcaa gaatagcatt     1320

gtaaaagcat tttgtaataa taaagaatag ctttaatgat atgcttgtaa ctaaaataat     1380

tttgtaatgt atcaaataca tttaaaacat taaaatataa tctctataat aa             1432


<210>  23
<211>  82
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary splice donor intron

<400>  23
gtaagtatca aggttacaag acaggtttaa ggagaccaat agaaactggg cttgtcgaga       60

cagagaagac tcttgcgttt ct                                                82


<210>  24
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary splice acceptor intron

<400>  24
gataggcacc tattggtctt actgacatcc actttgcctt tctctccaca g                51


<210>  25
<211>  225
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary bGH poly(A) signal sequence

<400>  25
ctgtgccttc tagttgccag ccatctgttg tttgcccctc ccccgtgcct tccttgaccc       60

tggaaggtgc cactcccact gtcctttcct aataaaatga ggaaattgca tcgcattgtc      120

tgagtaggtg tcattctatt ctggggggtg gggtggggca ggacagcaag ggggaggatt      180

gggaagacaa tagcaggcat gctggggatg cggtgggctc tatgg                      225


<210>  26
<211>  122
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary SV40 poly(A) signal sequence

<400>  26
aacttgttta ttgcagctta taatggttac aaataaagca atagcatcac aaatttcaca       60

aataaagcat ttttttcact gcattctagt tgtggtttgt ccaaactcat caatgtatct      120

ta                                                                     122


<210>  27
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic barcode C

<400>  27
cgtgtgtt                                                                 8


<210>  28
<211>  1097
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RBP7 promoter

<400>  28
cccatggctc tgttaaaatc aaagaaacat cttttccaac agccctttca aactcctcat       60

cgcatctcac tggctgattc agtcatttaa acctgcttct ccctaaagct gatcactggc      120

taagctaata gggtttccgg gattggttta gcctgatact aatccaggtc taccttcagg      180

agccagacca aactgcctat tggcattgca ttcttgcagt agggagggga ggtatggatg      240

gtgtggagtc caccacaagg tccatgccag tctttgctga accagcatca gactccatca      300

agcaacagat gagaggttcc atgataaagt ggccctcagc aatccccatc cattgctgtc      360

taggaagaac agtgcttgta cacaggttta ggacctcagt cttggctgta atcttctggt      420

ttactttgcc agcaccaaac agaaggaaag aaagggctca aatttgacca aataaattat      480

gcttctcctt ccagagataa ccttgagtcc tgtctaggaa gatattagaa ttgtaaagaa      540

aaaaaaaatt actccttatc ctatggcaag tggagtctat gtctacttca gctgaaatta      600

aatcctgtcc ataatagatg acccttgctc aagctggcca gaagccatac caaccagcac      660

gaaggttaaa actattatta gttttttctg tgattttcat tttcaggcca agttttagaa      720

caataagatt ttaagaatag gaagtaagta agatttctgc atatcctgtt ctcttagtca      780

gctgaatttt tttttttttt tttttagtcc taactcagcc tcccaaagtg ctgggattac      840

aggcgtgagc caccgcacca agcctggaat ctatgtctta cagttatgag aatcaacagc      900

tagctcatta tgggcaaggt gatgtcactc tggcttctca atgaaaatgg catttctccc      960

ttggaaaagg tcatagccag tcagtcagtc agtcacggga gcgcagcggc ttctaggggt     1020

gagtgggacc cacgcggccc cacctgctcc tcccgcgcgc ggccccaccc ccctgccccg     1080

ccccgcctgg tttatag                                                    1097


<210>  29
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary cloning site A

<400>  29
ttgtcgacgc ggccgcacgc gt                                                22


<210>  30
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary cloning site B

<400>  30
ctcctgggca acgtgctggt tattgtgacc ggtgccacc                              39


<210>  31
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary cloning site C

<400>  31
taagagctcg ctgatcagcc tcga                                              24


<210>  32
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary cloning site D

<400>  32
aagcttgaat tcagctgacg tgcctcggac cgcctagg                               38


<210>  33
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary cloning site E

<400>  33
taagagctc                                                                9


<210>  34
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary cloning site F

<400>  34
gctgatcagc ctcga                                                        15


<210>  35
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary cloning site G

<400>  35
ggcattccgg tactgttggt aaagccacca gcaaaccgcc cagagtagaa gaccggtggc       60

cacc                                                                    64


<210>  36
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary cloning site H

<400>  36
aagcttgaat tc                                                           12


<210>  37
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary cloning site I

<400>  37
agctgacgtg cctcggaccg cctagg                                            26


<210>  38
<211>  6334
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary construct sequence

<400>  38
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggccgcac gcgtggtaaa tagcttccaa cgtttccacc ccaccagccc      180

ttgcaccact ccctgtactg gccctgagct ttctagtctt gactgaaaag cggggaggca      240

atgtggtctc tcctggtgca ctgtcccgag gaaggcctgc tccgcttccc cggaggagtc      300

ttcaaaggat ggaggtaatt aataaaaaca acccctgtac ctcctctaag tggtcattaa      360

ttaataaaga acctccaggc tcctatagga gaggtctgtg caccccgcgg gctatgagaa      420

ggctggatca cccagaaaga ctgaggatgt gtcctggcaa aaacacagcc tgcccctcac      480

actgctcccc acgggtgcac tagggaggaa gagttccctc gagggcctga gcaggcgccc      540

cacacctgca cccgtgcaga gggggctggg cccgccctct gcgctcccga gggagagccc      600

taccccctgc atccccggta ccccgttccc tccaagggcc ggaaagaggg ccccgcgcac      660

tgtgcacttc ttaggggtcc cccaccctgc gcccccgcca cgggaaaaag gtccccgctc      720

tgcgcatccg gccccggagg gacagccccg gtcctgcact ccttgctcct cagggggacg      780

gtccgcgccc agcggctagt gcgccccggg taggtggggg cggggggctc gtcgagtgac      840

agcgctcgcc tcccgcagcc cgcccgagcc gcgtcagggc agaagctctg aggacccaga      900

ggccgggcgc gctccgcccg cggcgccgcc ccctccgtaa ctttcccagt ctccgaggga      960

agaggcgggg tgtggggtgc ggttaaaagg cgccacggcg ggagacaggt ctcaccggtt     1020

cgtgggtgtt gcggccccgc agcgcccgcg cgctcctctc cccgactcgg agcccctcgg     1080

cggcgcccgg cccaggaccc gcctaggagc gcaggagccc cagcgcagag accccaacgc     1140

cgagaccccc gccccggccc cgccgcgctt cctcccgacg cagtttagga cccttgttcg     1200

cgaagaggtg gtgtgcggct gagacccgcg tcctcaggac ggttccatca gtgcctcgat     1260

cctgccccac tggaggagga aggcagcccg aacagcgctc acctaactaa cagctgctga     1320

gagctgggtt ccgtggccat gcacctggga ctgccttgag aagcgtgagc aaaccgccca     1380

gagtagaagc gctagccacc atggattggg gcacgctgca gacgatcctg gggggtgtga     1440

acaaacactc caccagcatt ggaaagatct ggctcaccgt cctcttcatt tttcgcatta     1500

tgatcctcgt tgtggctgca aaggaggtgt ggggagatga gcaggccgac tttgtctgca     1560

acaccctgca gccaggctgc aagaacgtgt gctacgatca ctacttcccc atctcccaca     1620

tccggctatg ggccctgcag ctgatcttcg tgtccacgcc agcgctccta gtggccatgc     1680

acgtggccta ccggagacat gagaagaaga ggaagttcat caagggggag ataaagagtg     1740

aatttaagga catcgaggag atcaaaaccc agaaggtccg catcgaaggc tccctgtggt     1800

ggacctacac aagcagcatc ttcttccggg tcatcttcga agccgccttc atgtacgtct     1860

tctatgtcat gtacgacggc ttctccatgc agcggctggt gaagtgcaac gcctggcctt     1920

gtcccaacac tgtggactgc tttgtgtccc ggcccacgga gaagactgtc ttcacagtgt     1980

tcatgattgc agtgtctgga atttgcatcc tgctgaatgt cactgaattg tgttatttgc     2040

taattagata ttgttctggg aagtcaaaaa agccagttgg atcccgggct gactacaaag     2100

accatgacgg tgattataaa gatcatgaca tcgactacaa ggatgacgat gacaagtaag     2160

aaatagacag catgagaggg atgaggcaac ccgtgctcag ctgtcaaggc tcagtcgcta     2220

gcatttccca acacaaagat tctgacctta aatgcaacca tttgaaaccc ctgtaggcct     2280

caggtgaaac tccagatgcc acaatggagc tctgctcccc taaagcctca aaacaaaggc     2340

ctaattctat gcctgtctta attttctttc acttaagtta gttccactga gaccccaggc     2400

tgttaggggt tattggtgta aggtactttc atattttaaa cagaggatat cggcatttgt     2460

ttctttctct gaggacaaga gaaaaaagcc aggttccaca gaggacacag agaaggtttg     2520

ggtgtcctcc tggggttctt tttgccaact ttccccacgt taaaggtgaa cattggttct     2580

ttcatttgct ttggaagttt taatctctaa cagtggacaa agttaccagt gccttaaact     2640

ctgttacact ttttggaagt gaaaactttg tagtatgata ggttattttg atgtaaagat     2700

gttctggata ccattatatg ttccccctgt ttcagaggct cagattgtaa tatgtaaatg     2760

gtatgtcatt cgctactatg atttaatttg aaatatggtc ttttggttat gaatactttg     2820

cagcacagct gagaggctgt ctgttgtatt cattgtggtc atagcaccta acaacattgt     2880

agcctcaatc gagtgagaca gactagaagt tcctagtgat ggcttatgat agcaaatggc     2940

ctcatgtcaa atatttagat gtaattttgt gtaagaaata cagactggat gtaccaccaa     3000

ctactacctg taatgacagg cctgtccaac acatctccct tttccatgac tgtggtagcc     3060

agcatcggaa agaacgctga tttaaagagg tcgcttggga attttattga cacagtacca     3120

tttaatgggg aggacaaaat ggggcagggg agggagaagt ttctgtcgtt aaaaacagat     3180

ttggaaagac tggactctaa agtctgttga ttaaagatga gctttgtcta cttcaaaagt     3240

ttgtttgctt accccttcag cctccaattt tttaagtgaa aatatagcta ataacatgtg     3300

aaaagaatag aagctaaggt ttagataaat attgagcaga tctataggaa gattgaacct     3360

gaatattgcc attatgcttg acatggtttc caaaaaatgg tactccacat atttcagtga     3420

gggtaagtat tttcctgttg tcaagaatag cattgtaaaa gcattttgta ataataaaga     3480

atagctttaa tgatatgctt gtaactaaaa taattttgta atgtatcaaa tacatttaaa     3540

acattaaaat ataatctcta taataagagc tcgctgatca gcctcgactg tgccttctag     3600

ttgccagcca tctgttgttt gcccctcccc cgtgccttcc ttgaccctgg aaggtgccac     3660

tcccactgtc ctttcctaat aaaatgagga aattgcatcg cattgtctga gtaggtgtca     3720

ttctattctg gggggtgggg tggggcagga cagcaagggg gaggattggg aagacaatag     3780

caggcatgct ggggatgcgg tgggctctat ggaagcttga attcagctga cgtgcctcgg     3840

accgctagga acccctagtg atggagttgg ccactccctc tctgcgcgct cgctcgctca     3900

ctgaggccgg gcgaccaaag gtcgcccgac gcccgggctt tgcccgggcg gcctcagtga     3960

gcgagcgagc gcgcagctgc ctgcaggggc gcctgatgcg gtattttctc cttacgcatc     4020

tgtgcggtat ttcacaccgc atacgtcaaa gcaaccatag tacgcgccct gtagcggcgc     4080

attaagcgcg gcgggtgtgg tggttacgcg cagcgtgacc gctacacttg ccagcgccct     4140

agcgcccgct cctttcgctt tcttcccttc ctttctcgcc acgttcgccg gctttccccg     4200

tcaagctcta aatcgggggc tccctttagg gttccgattt agtgctttac ggcacctcga     4260

ccccaaaaaa cttgatttgg gtgatggttc acgtagtggg ccatcgccct gatagacggt     4320

ttttcgccct ttgacgttgg agtccacgtt ctttaatagt ggactcttgt tccaaactgg     4380

aacaacactc aaccctatct cgggctattc ttttgattta taagggattt tgccgatttc     4440

ggcctattgg ttaaaaaatg agctgattta acaaaaattt aacgcgaatt ttaacaaaat     4500

attaacgttt acaattttat ggtgcactct cagtacaatc tgctctgatg ccgcatagtt     4560

aagccagccc cgacacccgc caacacccgc tgacgcgccc tgacgggctt gtctgctccc     4620

ggcatccgct tacagacaag ctgtgaccgt ctccgggagc tgcatgtgtc agaggttttc     4680

accgtcatca ccgaaacgcg cgagacgaaa gggcctcgtg atacgcctat ttttataggt     4740

taatgtcatg aacaataaaa ctgtctgctt acataaacag taatacaagg ggtgttatga     4800

gccatattca acgggaaacg tcgaggccgc gattaaattc caacatggat gctgatttat     4860

atgggtataa atgggctcgc gataatgtcg ggcaatcagg tgcgacaatc tatcgcttgt     4920

atgggaagcc cgatgcgcca gagttgtttc tgaaacatgg caaaggtagc gttgccaatg     4980

atgttacaga tgagatggtc agactaaact ggctgacgga atttatgcct cttccgacca     5040

tcaagcattt tatccgtact cctgatgatg catggttact caccactgcg atccccggaa     5100

aaacagcatt ccaggtatta gaagaatatc ctgattcagg tgaaaatatt gttgatgcgc     5160

tggcagtgtt cctgcgccgg ttgcattcga ttcctgtttg taattgtcct tttaacagcg     5220

atcgcgtatt tcgtctcgct caggcgcaat cacgaatgaa taacggtttg gttgatgcga     5280

gtgattttga tgacgagcgt aatggctggc ctgttgaaca agtctggaaa gaaatgcata     5340

aacttttgcc attctcaccg gattcagtcg tcactcatgg tgatttctca cttgataacc     5400

ttatttttga cgaggggaaa ttaataggtt gtattgatgt tggacgagtc ggaatcgcag     5460

accgatacca ggatcttgcc atcctatgga actgcctcgg tgagttttct ccttcattac     5520

agaaacggct ttttcaaaaa tatggtattg ataatcctga tatgaataaa ttgcagtttc     5580

atttgatgct cgatgagttt ttctaatctc atgaccaaaa tcccttaacg tgagttttcg     5640

ttccactgag cgtcagaccc cgtagaaaag atcaaaggat cttcttgaga tccttttttt     5700

ctgcgcgtaa tctgctgctt gcaaacaaaa aaaccaccgc taccagcggt ggtttgtttg     5760

ccggatcaag agctaccaac tctttttccg aaggtaactg gcttcagcag agcgcagata     5820

ccaaatactg tccttctagt gtagccgtag ttaggccacc acttcaagaa ctctgtagca     5880

ccgcctacat acctcgctct gctaatcctg ttaccagtgg ctgctgccag tggcgataag     5940

tcgtgtctta ccgggttgga ctcaagacga tagttaccgg ataaggcgca gcggtcgggc     6000

tgaacggggg gttcgtgcac acagcccagc ttggagcgaa cgacctacac cgaactgaga     6060

tacctacagc gtgagctatg agaaagcgcc acgcttcccg aagggagaaa ggcggacagg     6120

tatccggtaa gcggcagggt cggaacagga gagcgcacga gggagcttcc agggggaaac     6180

gcctggtatc tttatagtcc tgtcgggttt cgccacctct gacttgagcg tcgatttttg     6240

tgatgctcgt caggggggcg gagcctatgg aaaaacgcca gcaacgcggc ctttttacgg     6300

ttcctggcct tttgctggcc ttttgctcac atgt                                 6334


<210>  39
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary synthetic barcode E

<400>  39
gcaaactg                                                                 8


<210>  40
<211>  1316
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PARM1 promoter

<400>  40
tgtacaggag atagtcaggg aattagtaat tttcaaagag gtgactttga attcaaactt       60

aaatatcatc ttcagctgaa acaaagaagg ggtgcagtta tgaggaagtg accaggtaaa      120

gcatggcaaa caaaggtaaa gtttgttatg cgtatttaag tcagagccct ctccattgat      180

aagagtttcc agtaatttag tgccatcctt ttcttgctat agagttctcg tctctatctg      240

agcacgcaaa aataacatgc tttcttgctt tcttgaagtt gggcatggcc attgacttgc      300

cttagcccat atttttctgt gaagtggtct tcaaaaacct atatttctgc catagagtca      360

cttacttaac ctgccctatt taaaggggct aatgcctgat agaatgtcgc tgcataactc      420

catctgtgtg tggtccctgc atccatgaca accaaaaccc agatgcagaa attgttccta      480

atcacataga ttaccctaga aaccggaagg gccttgaagt caaaagcatt cagagaacat      540

gctgaacaaa ttgaatttgc agtttatctg gccagggagg atggagaggg gatgggcact      600

tggtctgagt attttttgtt tctcattcca acagaaatta ctagatttac caaaaaatct      660

acaagtggta gtgtgataga gtcaggcaga ggaattgacc atagataagg tgctcaggac      720

tcctagagtc agcttctggt atgtgagaaa gaagtgagaa cagagcccat ggcatatgaa      780

gaagatatta cagaaaaaag aaagctgcct tccacgcaaa tcatttcttt acaaaggctt      840

gttaactcct gcagtgccaa gaagctgaat gcagcggcag acatcctggt tcgggcccca      900

ggaagctcag ccgggtttaa tgtggatgag ggtttaatga tgtacacgca gaagtgtttt      960

gacaaatgaa gaaggtcctc attcttggaa catgtgccgg ttctccgagg gaactcctaa     1020

aaggctgtaa gctcatgtag gaaaagctga gctagattcc taagggcaga gatgtgctca     1080

catttctttg catccctagt tcccagcaca gtgcaaggcg ctgcaaacat ttgctgaacc     1140

cagggtctcg tgtcttgact gtccagcaga ggccgctctg ggccggggct ctcgggacct     1200

gagggctgag agaaggaagg ccagggggtg gcccagtcat cgccgcgggg cccgggtggg     1260

aggggtttgg cagcggcagg cgcggcggcg gcggcggagg cggaggcggc cccggg         1316


<210>  41
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary synthetic barcode D

<400>  41
tcgtgggt                                                                 8


<210>  42
<211>  78
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary 3xFLAG tag sequence

<400>  42
ggatcccggg ctgactacaa agaccatgac ggtgattata aagatcatga catcgactac       60

aaggatgacg atgacaag                                                     78


<210>  43
<211>  2208
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary AAV Anc80 Capsid DNA Sequence

<400>  43
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acttgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gaccggtaga gcaatcaccc caggaaccag actcctcttc gggcatcggc      480

aagaaaggcc agcagcccgc gaagaagaga ctcaactttg ggcagacagg cgactcagag      540

tcagtgcccg accctcaacc actcggagaa ccccccgcag ccccctctgg tgtgggatct      600

aatacaatgg cagcaggcgg tggcgctcca atggcagaca ataacgaagg cgccgacgga      660

gtgggtaacg cctcaggaaa ttggcattgc gattccacat ggctgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctcccc acctacaaca accacctcta caagcaaatc      780

tccagccaat cgggagcaag caccaacgac aacacctact tcggctacag caccccctgg      840

gggtattttg actttaacag attccactgc cacttctcac cacgtgactg gcagcgactc      900

atcaacaaca actggggatt ccggcccaag agactcaact tcaagctctt caacatccag      960

gtcaaggagg tcacgacgaa tgatggcacc acgaccatcg ccaataacct taccagcacg     1020

gttcaggtct ttacggactc ggaataccag ctcccgtacg tcctcggctc tgcgcaccag     1080

ggctgcctgc ctccgttccc ggcggacgtc ttcatgattc ctcagtacgg gtacctgact     1140

ctgaacaatg gcagtcaggc cgtgggccgt tcctccttct actgcctgga gtactttcct     1200

tctcaaatgc tgagaacggg caacaacttt gagttcagct acacgtttga ggacgtgcct     1260

tttcacagca gctacgcgca cagccaaagc ctggaccggc tgatgaaccc cctcatcgac     1320

cagtacctgt actacctgtc tcggactcag accacgagtg gtaccgcagg aaatcggacg     1380

ttgcaatttt ctcaggccgg gcctagtagc atggcgaatc aggccaaaaa ctggctaccc     1440

gggccctgct accggcagca acgcgtctcc aagacagcga atcaaaataa caacagcaac     1500

tttgcctgga ccggtgccac caagtatcat ctgaatggca gagactctct ggtaaatccc     1560

ggtcccgcta tggcaaccca caaggacgac gaagacaaat tttttccgat gagcggagtc     1620

ttaatatttg ggaaacaggg agctggaaat agcaacgtgg accttgacaa cgttatgata     1680

accagtgagg aagaaattaa aaccaccaac ccagtggcca cagaacagta cggcacggtg     1740

gccactaacc tgcaatcgtc aaacaccgct cctgctacag ggaccgtcaa cagtcaagga     1800

gccttacctg gcatggtctg gcagaaccgg gacgtgtacc tgcagggtcc tatctgggcc     1860

aagattcctc acacggacgg acactttcat ccctcgccgc tgatgggagg ctttggactg     1920

aaacacccgc ctcctcagat cctgattaag aatacacctg ttcccgcgaa tcctccaact     1980

accttcagtc cagctaagtt tgcgtcgttc atcacgcagt acagcaccgg acaggtcagc     2040

gtggaaattg aatgggagct gcagaaagaa aacagcaaac gctggaaccc agagattcaa     2100

tacacttcca actacaacaa atctacaaat gtggactttg ctgttgacac aaatggcgtt     2160

tattctgagc ctcgccccat cggcacccgt tacctcaccc gtaatctg                  2208


<210>  44
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary AAV Anc80 Capsid Amino Acid Sequence

<400>  44

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Asn Thr Met Ala Ala Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Thr Asn Asp Asn Thr 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg 
        435                 440                 445             


Thr Gln Thr Thr Ser Gly Thr Ala Gly Asn Arg Thr Leu Gln Phe Ser 
    450                 455                 460                 


Gln Ala Gly Pro Ser Ser Met Ala Asn Gln Ala Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ala Asn Gln Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His Leu Asn 
            500                 505                 510         


Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Thr His Lys 
        515                 520                 525             


Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Ala Gly Asn Ser Asn Val Asp Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Gln 
                565                 570                 575     


Tyr Gly Thr Val Ala Thr Asn Leu Gln Ser Ser Asn Thr Ala Pro Ala 
            580                 585                 590         


Thr Gly Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Thr Thr Phe Ser Pro Ala Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Asn Lys Ser Thr Asn Val Asp Phe Ala Val Asp Thr Asn Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  45
<211>  2989
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary construct sequence

<400>  45
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgcccgggc aaagcccggg       60

cgtcgggcga cctttggtcg cccggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcctttgtc gacgcggccg cacgcgtgac attgattatt      180

gactagttat taatagtaat caattacggg gtcattagtt catagcccat atatggagtt      240

ccgcgttaca taacttacgg taaatggccc gcctggctga ccgcccaacg acccccgccc      300

attgacgtca ataatgacgt atgttcccat agtaacgcca atagggactt tccattgacg      360

tcaatgggtg gactatttac ggtaaactgc ccacttggca gtacatcaag tgtatcatat      420

gccaagtacg ccccctattg acgtcaatga cggtaaatgg cccgcctggc attatgccca      480

gtacatgacc ttatgggact ttcctacttg gcagtacatc tacgtattag tcatcgctat      540

taccatgggt cgaggtgagc cccacgttct gcttcactct ccccatctcc cccccctccc      600

cacccccaat tttgtattta tttatttttt aattattttg tgcagcgatg ggggcggggg      660

gggggggggg gcgcgcgcca ggcggggcgg ggcggggcga ggggcggggc ggggcgaggc      720

ggagaggtgc ggcggcagcc aatcagagcg gcgcgctccg aaagtttcct tttatggcga      780

ggcggcggcg gcggcggccc tataaaaagc gaagcgcgcg gcgggcggga gtcgctgcgt      840

tgccttcgcc ccgtgccccg ctccgcgccg cctcgcgccg cccgccccgg ctctgactga      900

ccgcgttact cccacaggtg agcgggcggg acggcccttc tcctccgggc tgtaattagc      960

gcttggttta atgacggctc gtttcttttc tgtggctgcg tgaaagcctt aaagggctcc     1020

gggagggccc tttgtgcggg ggggagcggc tcggggggtg cgtgcgtgtg tgtgtgcgtg     1080

gggagcgccg cgtgcggccc gcgctgcccg gcggctgtga gcgctgcggg cgcggcgcgg     1140

ggctttgtgc gctccgcgtg tgcgcgaggg gagcgcggcc gggggcggtg ccccgcggtg     1200

cgggggggct gcgaggggaa caaaggctgc gtgcggggtg tgtgcgtggg ggggtgagca     1260

gggggtgtgg gcgcggcggt cgggctgtaa cccccccctg cacccccctc cccgagttgc     1320

tgagcacggc ccggcttcgg gtgcggggct ccgtgcgggg cgtggcgcgg ggctcgccgt     1380

gccgggcggg gggtggcggc aggtgggggt gccgggcggg gcggggccgc ctcgggccgg     1440

ggagggctcg ggggaggggc gcggcggccc ccggagcgcc ggcggctgtc gaggcgcggc     1500

gagccgcagc cattgccttt tatggtaatc gtgcgagagg gcgcagggac ttcctttgtc     1560

ccaaatctgt gcggagccga aatctgggag gcgccgccgc accccctcta gcgggcgcgg     1620

ggcgaagcgg tgcggcgccg gcaggaagga aatgggcggg gagggccttc gtgcgtcgcc     1680

gcgccgccgt ccccttctcc ctctccagcc tcggggctgt ccgcgggggg acggctgcct     1740

tcggggggga cggggcaggg cggggttcgg cttctggcgt gtgaccggcg gctctagagc     1800

ctctgctaac catgttcatg ccttcttctt tttcctacag ctcctgggca acgtgctggt     1860

tattgtgacc ggtgccacca tggattgggg cacgctgcag acgatcctgg ggggtgtgaa     1920

caaacactcc accagcattg gaaagatctg gctcaccgtc ctcttcattt ttcgcattat     1980

gatcctcgtt gtggctgcaa aggaggtgtg gggagatgag caggccgact ttgtctgcaa     2040

caccctgcag ccaggctgca agaacgtgtg ctacgatcac tacttcccca tctcccacat     2100

ccggctatgg gccctgcagc tgatcttcgt gtccacgcca gcgctcctag tggccatgca     2160

cgtggcctac cggagacatg agaagaagag gaagttcatc aagggggaga taaagagtga     2220

atttaaggac atcgaggaga tcaaaaccca gaaggtccgc atcgaaggct ccctgtggtg     2280

gacctacaca agcagcatct tcttccgggt catcttcgaa gccgccttca tgtacgtctt     2340

ctatgtcatg tacgacggct tctccatgca gcggctggtg aagtgcaacg cctggccttg     2400

tcccaacact gtggactgct ttgtgtcccg gcccacggag aagactgtct tcacagtgtt     2460

catgattgca gtgtctggaa tttgcatcct gctgaatgtc actgaattgt gttatttgct     2520

aattagatat tgttctggga agtcaaaaaa gccagtttaa gagctcgctg atcagcctcg     2580

actgtgcctt ctagttgcca gccatctgtt gtttgcccct cccccgtgcc ttccttgacc     2640

ctggaaggtg ccactcccac tgtcctttcc taataaaatg aggaaattgc atcgcattgt     2700

ctgagtaggt gtcattctat tctggggggt ggggtggggc aggacagcaa gggggaggat     2760

tgggaagaca atagcaggca tgctggggat gcggtgggct ctatggaagc ttgaattcag     2820

ctgacgtgcc tcggaccgcc taggaggaac ccctagtgat ggagttggcc actccctctc     2880

tgcgcgctcg ctcgctcact gaggccgggc gaccaaaggt cgcccgacgc ccgggctttg     2940

cccgggcggc ctcagtgagc gagcgagcgc gcagagaggg agtggccaa                 2989


<210>  46
<211>  4421
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary construct sequence

<400>  46
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgcccgggc aaagcccggg       60

cgtcgggcga cctttggtcg cccggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcctttgtc gacgcggccg cacgcgtgac attgattatt      180

gactagttat taatagtaat caattacggg gtcattagtt catagcccat atatggagtt      240

ccgcgttaca taacttacgg taaatggccc gcctggctga ccgcccaacg acccccgccc      300

attgacgtca ataatgacgt atgttcccat agtaacgcca atagggactt tccattgacg      360

tcaatgggtg gactatttac ggtaaactgc ccacttggca gtacatcaag tgtatcatat      420

gccaagtacg ccccctattg acgtcaatga cggtaaatgg cccgcctggc attatgccca      480

gtacatgacc ttatgggact ttcctacttg gcagtacatc tacgtattag tcatcgctat      540

taccatgggt cgaggtgagc cccacgttct gcttcactct ccccatctcc cccccctccc      600

cacccccaat tttgtattta tttatttttt aattattttg tgcagcgatg ggggcggggg      660

gggggggggg gcgcgcgcca ggcggggcgg ggcggggcga ggggcggggc ggggcgaggc      720

ggagaggtgc ggcggcagcc aatcagagcg gcgcgctccg aaagtttcct tttatggcga      780

ggcggcggcg gcggcggccc tataaaaagc gaagcgcgcg gcgggcggga gtcgctgcgt      840

tgccttcgcc ccgtgccccg ctccgcgccg cctcgcgccg cccgccccgg ctctgactga      900

ccgcgttact cccacaggtg agcgggcggg acggcccttc tcctccgggc tgtaattagc      960

gcttggttta atgacggctc gtttcttttc tgtggctgcg tgaaagcctt aaagggctcc     1020

gggagggccc tttgtgcggg ggggagcggc tcggggggtg cgtgcgtgtg tgtgtgcgtg     1080

gggagcgccg cgtgcggccc gcgctgcccg gcggctgtga gcgctgcggg cgcggcgcgg     1140

ggctttgtgc gctccgcgtg tgcgcgaggg gagcgcggcc gggggcggtg ccccgcggtg     1200

cgggggggct gcgaggggaa caaaggctgc gtgcggggtg tgtgcgtggg ggggtgagca     1260

gggggtgtgg gcgcggcggt cgggctgtaa cccccccctg cacccccctc cccgagttgc     1320

tgagcacggc ccggcttcgg gtgcggggct ccgtgcgggg cgtggcgcgg ggctcgccgt     1380

gccgggcggg gggtggcggc aggtgggggt gccgggcggg gcggggccgc ctcgggccgg     1440

ggagggctcg ggggaggggc gcggcggccc ccggagcgcc ggcggctgtc gaggcgcggc     1500

gagccgcagc cattgccttt tatggtaatc gtgcgagagg gcgcagggac ttcctttgtc     1560

ccaaatctgt gcggagccga aatctgggag gcgccgccgc accccctcta gcgggcgcgg     1620

ggcgaagcgg tgcggcgccg gcaggaagga aatgggcggg gagggccttc gtgcgtcgcc     1680

gcgccgccgt ccccttctcc ctctccagcc tcggggctgt ccgcgggggg acggctgcct     1740

tcggggggga cggggcaggg cggggttcgg cttctggcgt gtgaccggcg gctctagagc     1800

ctctgctaac catgttcatg ccttcttctt tttcctacag ctcctgggca acgtgctggt     1860

tattgtgacc ggtgccacca tggattgggg cacgctgcag acgatcctgg ggggtgtgaa     1920

caaacactcc accagcattg gaaagatctg gctcaccgtc ctcttcattt ttcgcattat     1980

gatcctcgtt gtggctgcaa aggaggtgtg gggagatgag caggccgact ttgtctgcaa     2040

caccctgcag ccaggctgca agaacgtgtg ctacgatcac tacttcccca tctcccacat     2100

ccggctatgg gccctgcagc tgatcttcgt gtccacgcca gcgctcctag tggccatgca     2160

cgtggcctac cggagacatg agaagaagag gaagttcatc aagggggaga taaagagtga     2220

atttaaggac atcgaggaga tcaaaaccca gaaggtccgc atcgaaggct ccctgtggtg     2280

gacctacaca agcagcatct tcttccgggt catcttcgaa gccgccttca tgtacgtctt     2340

ctatgtcatg tacgacggct tctccatgca gcggctggtg aagtgcaacg cctggccttg     2400

tcccaacact gtggactgct ttgtgtcccg gcccacggag aagactgtct tcacagtgtt     2460

catgattgca gtgtctggaa tttgcatcct gctgaatgtc actgaattgt gttatttgct     2520

aattagatat tgttctggga agtcaaaaaa gccagtttaa gagctccgca ttgcccagtt     2580

gttagattaa gaaatagaca gcatgagagg gatgaggcaa cccgtgctca gctgtcaagg     2640

ctcagtcgct agcatttccc aacacaaaga ttctgacctt aaatgcaacc atttgaaacc     2700

cctgtaggcc tcaggtgaaa ctccagatgc cacaatggag cctctgctcc cctaaagcct     2760

caaaacaaag gcctaattct atgcctgtct taattttctt tcacttaagt tagttccact     2820

gagaccccag gctgttaggg gttattggtg taaggtactt tcatatttta aacagaggat     2880

atcggcattt gtttctttct ctgaggacaa gagaaaaaag ccaggttcca cagaggacac     2940

agagaaggtt tgggtgtcct cctggggttc tttttgccaa ctttccccac gttaaaggtg     3000

aacattggtt ctttcatttg ctttggaagt tttaatctct aacagtggac aaagttacca     3060

gtgccttaaa ctctgttaca ctttttggaa gtgaaaactt tgtagtatga taggttattt     3120

tgatgtaaag atgttctgga taccattata tgttccccct gtttcagagg ctcagattgt     3180

aatatgtaaa tggtatgtca ttcgctacta tgatttaatt tgaaatatgg tcttttggtt     3240

atgaatactt tgcagcacag ctgagaggct gtctgttgta ttcattgtgg tcatagcacc     3300

taacaacatt gtagcctcaa tcgagtgaga cagactagaa gttcctagtg atggcttatg     3360

atagcaaatg gcctcatgtc aaatatttag atgtaatttt gtgtaagaaa tacagactgg     3420

atgtaccacc aactactacc tgtaatgaca ggcctgtcca acacatctcc cttttccatg     3480

actgtggtag ccagcatcgg aaagaacgct gatttaaaga ggtcgcttgg gaattttatt     3540

gacacagtac catttaatgg ggaggacaaa atggggcagg ggagggagaa gtttctgtcg     3600

ttaaaaacag atttggaaag actggactct aaagtctgtt gattaaagat gagctttgtc     3660

tacttcaaaa gtttgtttgc ttaccccttc agcctccaat tttttaagtg aaaatatagc     3720

taataacatg tgaaaagaat agaagctaag gtttagataa atattgagca gatctatagg     3780

aagattgaac ctgaatattg ccattatgct tgacatggtt tccaaaaaat ggtactccac     3840

atatttcagt gagggtaagt attttcctgt tgtcaagaat agcattgtaa aagcattttg     3900

taataataaa gaatagcttt aatgatatgc ttgtaactaa aataattttg taatgtatca     3960

aatacattta aaacattaaa atataatctc tataataagc tgatcagcct cgactgtgcc     4020

ttctagttgc cagccatctg ttgtttgccc ctcccccgtg ccttccttga ccctggaagg     4080

tgccactccc actgtccttt cctaataaaa tgaggaaatt gcatcgcatt gtctgagtag     4140

gtgtcattct attctggggg gtggggtggg gcaggacagc aagggggagg attgggaaga     4200

caatagcagg catgctgggg atgcggtggg ctctatggaa gcttgaattc agctgacgtg     4260

cctcggaccg cctaggagga acccctagtg atggagttgg ccactccctc tctgcgcgct     4320

cgctcgctca ctgaggccgg gcgaccaaag gtcgcccgac gcccgggctt tgcccgggcg     4380

gcctcagtga gcgagcgagc gcgcagagag ggagtggcca a                         4421


<210>  47
<211>  3938
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary construct sequence

<400>  47
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgcccgggc aaagcccggg       60

cgtcgggcga cctttggtcg cccggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcctttgtc gacgcggccg cacgcgtaag cttcggtgaa      180

tttaaaacgt ttggtggcag tgggtcaagt agccaggcgg ctgcgctaga gtaccccgaa      240

gggacatcgg cgacaccaca aacctcgcgc tggcggctcg cccgcgcctt tttcccctcc      300

cgcgcgcgcc cggccccact cgcaccccgg gcggtgccat cgcgtccact tccccggccg      360

ccccattcca gctccggagc tcggccgcag aaacgcccgc tccagaaggc ggcccccgcc      420

ccccggccca aggacgtgtg ttggtccagc cccccggttc cccgagaccc acgcggccgg      480

gcaaccgctc tgggtctcgc ggtccctccc cgcgccaggt tcctggccgg gcagtccggg      540

gccggcgggc tcacctgcgt cgggaggaag cgcggcgggg ccggggcggg ggtctcggcg      600

ttggggtctc tgcgctgggg ctcctgcgct cctaggcggg tcctgggccg ggcgccgccg      660

aggggctccg agtcggggag aggagcgcgc gggcgctgcg gggccgcaac acctgtctcc      720

cgccgtggcg ccttttaacc gcaccccaca ccccgcctct tccctcggag actgggaaag      780

ttacggaggg ggcggcgccg cgggcggagc gcgcccggcc tctgggtcct cagagcttcc      840

cgggtccgcg aacccccgac cgcccccgaa agccccgaac cccccaagtc cccttcgagg      900

tcccgatctc ctagttcctt tgagccccca tgagttcccc aagtgccccc agcgccctga      960

gtctcccccg gttaccccga gcgccgcctc ccccagcccc ttggcggccc gggtgaagcg     1020

ggggcggctg agagtcggga ccccccagga agcggcgccc cagaccccgg ctccggcgct     1080

gtgccgtggg cggggttcag ggatggctgt ggtcgttgtc ctctgtactc cgcatagtgc     1140

gagaggactt ggcatttatg agcgcttctt taatttttta ttgttagaga aacaggcatt     1200

cctccaagga ctgaagatct gttcgagtcg cggaggctgc gcgggcccgc gaggctctcg     1260

cagggggacc taggctgggt ggcggggcag tgccctctgg aatgggggtt aacggtggcc     1320

gaggaggggg cgccgctggt gccggcgaag tccccgcttc tttctcccct caaaatctca     1380

ccaatccgaa cgaacgcctt ctcgaatttc cgattttatt caattacttt caacaatgtg     1440

ccaaggacta aggttggggg cggtgggaga gacaagcctc gtttttgcca tggccggcag     1500

gggggtcccg ccatctgcgg agggtgcccc ccgcggcccc cggcccagcc aacttcctcc     1560

tcttttcgca actggggaac tgcaaggagg tgactccttt cggggtgagg aggcccagac     1620

ttttcagaaa ggaaagaggg caggtaaaac ctgccaagcc ccttcctgct cgatgcacac     1680

agcacgaaag ggggaaactg ataggattct gcggaagctt ggcattccgg tactgttggt     1740

aaagccacca gcaaaccgcc cagagtagaa gaccggtggc caccatggat tggggcacgc     1800

tgcagacgat cctggggggt gtgaacaaac actccaccag cattggaaag atctggctca     1860

ccgtcctctt catttttcgc attatgatcc tcgttgtggc tgcaaaggag gtgtggggag     1920

atgagcaggc cgactttgtc tgcaacaccc tgcagccagg ctgcaagaac gtgtgctacg     1980

atcactactt ccccatctcc cacatccggc tatgggccct gcagctgatc ttcgtgtcca     2040

cgccagcgct cctagtggcc atgcacgtgg cctaccggag acatgagaag aagaggaagt     2100

tcatcaaggg ggagataaag agtgaattta aggacatcga ggagatcaaa acccagaagg     2160

tccgcatcga aggctccctg tggtggacct acacaagcag catcttcttc cgggtcatct     2220

tcgaagccgc cttcatgtac gtcttctatg tcatgtacga cggcttctcc atgcagcggc     2280

tggtgaagtg caacgcctgg ccttgtccca acactgtgga ctgctttgtg tcccggccca     2340

cggagaagac tgtcttcaca gtgttcatga ttgcagtgtc tggaatttgc atcctgctga     2400

atgtcactga attgtgttat ttgctaatta gatattgttc tgggaagtca aaaaagccag     2460

tttaagagct cgctgatcag cctcgactgt gccttctagt tgccagccat ctgttgtttg     2520

cccctccccc gtgccttcct tgaccctgga aggtgccact cccactgtcc tttcctaata     2580

aaatgaggaa attgcatcgc attgtctgag taggtgtcat tctattctgg ggggtggggt     2640

ggggcaggac agcaaggggg aggattggga agacaatagc aggcatgctg gggatgcggt     2700

gggctctatg gaagcttgaa ttccttcttc tggagtcttt tctggaataa ttctgggagt     2760

gggctcagcc tgcgggagag taacattttt ataacttgat agatgtagct gagatgcctc     2820

ccagagggga gacccgcctc tcctccggca gctgtgcacg taggcttgtt cccagcagcc     2880

tggccagggt ggtccacctg gtgtttctca tcttctttcc ccggagcgct gactcctgcg     2940

cgtcctcttg gaagactctt gacaggacgg gtgttttatg ggtgtgattc agtgtcctct     3000

tgcatcagtt caatgtggtg gtgttcaatc aacccttgta gcgttagcaa aatttgctca     3060

agtcattccg caggaatgtc tgtgtcttgc ttccaagaaa gcttgtaagt gccggcaaca     3120

ggccaagcag ctcacaaacc tgaccacaag cctgtgagta attgtggggc agcacttagc     3180

agtcttttat tttcgactta ttaaagtctc atcttggcct caccttctcc ctggaaggtg     3240

gcgtgggtgg gaaccactgg gtcagatctt tttcaccctt gccgtggagc cagtttcctg     3300

ttgcatgtgg gggaagcaac atgtggtgaa gagtatagaa aacgaaaaca tgtgggtaca     3360

gtatgtataa gtggagggaa caaactcata attccaacta gtttctcatg agagactcat     3420

gaatcattgt ggtagttctc aatataaact taatctaggc cggatgtggt ggctcacacc     3480

tgtaatctca gcactctggg tggatcactt gaggtcagga gtttgagacc agtctgacca     3540

acatggagaa accccatcgc tactaaaaat acaaaattat ccagatgtgg tggctcacac     3600

ctgtaatccc agcactttgg gaggctgagg cgggtggatc acttgaggtc aggagtttga     3660

gaccagcctg accaacatgg agaaactgtg tctctactaa aaatacaaaa ttagctgggc     3720

gtggtgacgc atgcctgtaa tcccagctat ttggaggccg aagcaggagc tgacgtgcct     3780

cggaccgcct aggaggaacc cctagtgatg gagttggcca ctccctctct gcgcgctcgc     3840

tcgctcactg aggccgggcg accaaaggtc gcccgacgcc cgggctttgc ccgggcggcc     3900

tcagtgagcg agcgagcgcg cagagaggga gtggccaa                             3938


<210>  48
<211>  3916
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary construct sequence

<400>  48
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgcccgggc aaagcccggg       60

cgtcgggcga cctttggtcg cccggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcctttgtc gacgcggccg cacgcgtaag cttcggtgaa      180

tttaaaacgt ttggtggcag tgggtcaagt agccaggcgg ctgcgctaga gtaccccgaa      240

gggacatcgg cgacaccaca aacctcgcgc tggcggctcg cccgcgcctt tttcccctcc      300

cgcgcgcgcc cggccccact cgcaccccgg gcggtgccat cgcgtccact tccccggccg      360

ccccattcca gctccggagc tcggccgcag aaacgcccgc tccagaaggc ggcccccgcc      420

ccccggccca aggacgtgtg ttggtccagc cccccggttc cccgagaccc acgcggccgg      480

gcaaccgctc tgggtctcgc ggtccctccc cgcgccaggt tcctggccgg gcagtccggg      540

gccggcgggc tcacctgcgt cgggaggaag cgcggcgggg ccggggcggg ggtctcggcg      600

ttggggtctc tgcgctgggg ctcctgcgct cctaggcggg tcctgggccg ggcgccgccg      660

aggggctccg agtcggggag aggagcgcgc gggcgctgcg gggccgcaac acctgtctcc      720

cgccgtggcg ccttttaacc gcaccccaca ccccgcctct tccctcggag actgggaaag      780

ttacggaggg ggcggcgccg cgggcggagc gcgcccggcc tctgggtcct cagagcttcc      840

cgggtccgcg aacccccgac cgcccccgaa agccccgaac cccccaagtc cccttcgagg      900

tcccgatctc ctagttcctt tgagccccca tgagttcccc aagtgccccc agcgccctga      960

gtctcccccg gttaccccga gcgccgcctc ccccagcccc ttggcggccc gggtgaagcg     1020

ggggcggctg agagtcggga ccccccagga agcggcgccc cagaccccgg ctccggcgct     1080

gtgccgtggg cggggttcag ggatggctgt ggtcgttgtc ctctgtactc cgcatagtgc     1140

gagaggactt ggcatttatg agcgcttctt taatttttta ttgttagaga aacaggcatt     1200

cctccaagga ctgaagatct gttcgagtcg cggaggctgc gcgggcccgc gaggctctcg     1260

cagggggacc taggctgggt ggcggggcag tgccctctgg aatgggggtt aacggtggcc     1320

gaggaggggg cgccgctggt gccggcgaag tccccgcttc tttctcccct caaaatctca     1380

ccaatccgaa cgaacgcctt ctcgaatttc cgattttatt caattacttt caacaatgtg     1440

ccaaggacta aggttggggg cggtgggaga gacaagcctc gtttttgcca tggccggcag     1500

gggggtcccg ccatctgcgg agggtgcccc ccgcggcccc cggcccagcc aacttcctcc     1560

tcttttcgca actggggaac tgcaaggagg tgactccttt cggggtgagg aggcccagac     1620

ttttcagaaa ggaaagaggg caggtaaaac ctgccaagcc ccttcctgct cgatgcacac     1680

agcacgaaag ggggaaactg ataggattct gcggaagctt ggcattccgg tactgttggt     1740

aaagccacca gcaaaccgcc cagagtagaa gaccggtggc caccatggat tggggcacgc     1800

tgcagacgat cctggggggt gtgaacaaac actccaccag cattggaaag atctggctca     1860

ccgtcctctt catttttcgc attatgatcc tcgttgtggc tgcaaaggag gtgtggggag     1920

atgagcaggc cgactttgtc tgcaacaccc tgcagccagg ctgcaagaac gtgtgctacg     1980

atcactactt ccccatctcc cacatccggc tatgggccct gcagctgatc ttcgtgtcca     2040

cgccagcgct cctagtggcc atgcacgtgg cctaccggag acatgagaag aagaggaagt     2100

tcatcaaggg ggagataaag agtgaattta aggacatcga ggagatcaaa acccagaagg     2160

tccgcatcga aggctccctg tggtggacct acacaagcag catcttcttc cgggtcatct     2220

tcgaagccgc cttcatgtac gtcttctatg tcatgtacga cggcttctcc atgcagcggc     2280

tggtgaagtg caacgcctgg ccttgtccca acactgtgga ctgctttgtg tcccggccca     2340

cggagaagac tgtcttcaca gtgttcatga ttgcagtgtc tggaatttgc atcctgctga     2400

atgtcactga attgtgttat ttgctaatta gatattgttc tgggaagtca aaaaagccag     2460

tttaagagct cgctgatcag cctcgactgt gccttctagt tgccagccat ctgttgtttg     2520

cccctccccc gtgccttcct tgaccctgga aggtgccact cccactgtcc tttcctaata     2580

aaatgaggaa attgcatcgc attgtctgag taggtgtcat tctattctgg ggggtggggt     2640

ggggcaggac agcaaggggg aggattggga agacaatagc aggcatgctg gggatgcggt     2700

gggctctatg gaagcttgaa ttccctgtaa agccaattcc aacccacttg taattaagag     2760

aaaatcccac ggttcctaat tgaaagtcct ttgttctatt tcttgggtat ttgtgtttta     2820

ggccttattt ttagatgcat cattaaagat ttttaaagtc ctttcaggca tcaggactga     2880

tgatgctgaa tgatggaggg ttgtggataa gtttttttgt ttttttttta accaggttaa     2940

aggctttcct gttatcctac tatgcttaat taagagctgt atttcttaat atcattggtg     3000

cctgattaga tttaactttt agatacagtc tgtaagattt ttgaaccaga aaaacctaaa     3060

taacttatga ctgttagcag tcatattcta gaagaagcaa atgtactgaa ttcttatgta     3120

cctaggattt taagggagta catacaaatc tttcctcagt agcaggtact ttatttttat     3180

aacacacaca tttaagctga gttaaatatg cagaactggt tgtacttctt tggcaggaaa     3240

agggaagctt aggatatctt gtgaccaact acctcttcct tctcaaataa ctggcaaata     3300

acttcaggaa aatccagtta tgttgtgtca tattgcaccc cctaggaagt actggattct     3360

tagtcttgag tgacttttaa ataaagctac ctttttctct ttcttacatc gcaagatctt     3420

caaatgtacc attcccgcac agagagtcca aggtaaaagg actgaaacca aactttgttt     3480

ttgtaagtat tttggtcagt gcaatgagtt cagagaccag gaggttaatg attgtgaagt     3540

cttgtcaaca gcaacaccgt gtatgacctg tggtgcttag atgttcagaa accccaaggt     3600

taaaatgtcc ctgaccacat atcaggcaaa aggaatgtaa ggaaaaccaa cttaatcctt     3660

ttgtcaagaa gtataaatga tgtatctttc caatcgggtt gcattgactt ttgggtccaa     3720

atagcttgtg tccacaggca tcttcagctg acgtgcctcg gaccgcctag gaggaacccc     3780

tagtgatgga gttggccact ccctctctgc gcgctcgctc gctcactgag gccgggcgac     3840

caaaggtcgc ccgacgcccg ggctttgccc gggcggcctc agtgagcgag cgagcgcgca     3900

gagagggagt ggccaa                                                     3916


<210>  49
<211>  2894
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary construct sequence

<400>  49
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgcccgggc aaagcccggg       60

cgtcgggcga cctttggtcg cccggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcctttgtc gacgcggccg cacgcgtaag cttcggtgaa      180

tttaaaacgt ttggtggcag tgggtcaagt agccaggcgg ctgcgctaga gtaccccgaa      240

gggacatcgg cgacaccaca aacctcgcgc tggcggctcg cccgcgcctt tttcccctcc      300

cgcgcgcgcc cggccccact cgcaccccgg gcggtgccat cgcgtccact tccccggccg      360

ccccattcca gctccggagc tcggccgcag aaacgcccgc tccagaaggc ggcccccgcc      420

ccccggccca aggacgtgtg ttggtccagc cccccggttc cccgagaccc acgcggccgg      480

gcaaccgctc tgggtctcgc ggtccctccc cgcgccaggt tcctggccgg gcagtccggg      540

gccggcgggc tcacctgcgt cgggaggaag cgcggcgggg ccggggcggg ggtctcggcg      600

ttggggtctc tgcgctgggg ctcctgcgct cctaggcggg tcctgggccg ggcgccgccg      660

aggggctccg agtcggggag aggagcgcgc gggcgctgcg gggccgcaac acctgtctcc      720

cgccgtggcg ccttttaacc gcaccccaca ccccgcctct tccctcggag actgggaaag      780

ttacggaggg ggcggcgccg cgggcggagc gcgcccggcc tctgggtcct cagagcttcc      840

cgggtccgcg aacccccgac cgcccccgaa agccccgaac cccccaagtc cccttcgagg      900

tcccgatctc ctagttcctt tgagccccca tgagttcccc aagtgccccc agcgccctga      960

gtctcccccg gttaccccga gcgccgcctc ccccagcccc ttggcggccc gggtgaagcg     1020

ggggcggctg agagtcggga ccccccagga agcggcgccc cagaccccgg ctccggcgct     1080

gtgccgtggg cggggttcag ggatggctgt ggtcgttgtc ctctgtactc cgcatagtgc     1140

gagaggactt ggcatttatg agcgcttctt taatttttta ttgttagaga aacaggcatt     1200

cctccaagga ctgaagatct gttcgagtcg cggaggctgc gcgggcccgc gaggctctcg     1260

cagggggacc taggctgggt ggcggggcag tgccctctgg aatgggggtt aacggtggcc     1320

gaggaggggg cgccgctggt gccggcgaag tccccgcttc tttctcccct caaaatctca     1380

ccaatccgaa cgaacgcctt ctcgaatttc cgattttatt caattacttt caacaatgtg     1440

ccaaggacta aggttggggg cggtgggaga gacaagcctc gtttttgcca tggccggcag     1500

gggggtcccg ccatctgcgg agggtgcccc ccgcggcccc cggcccagcc aacttcctcc     1560

tcttttcgca actggggaac tgcaaggagg tgactccttt cggggtgagg aggcccagac     1620

ttttcagaaa ggaaagaggg caggtaaaac ctgccaagcc ccttcctgct cgatgcacac     1680

agcacgaaag ggggaaactg ataggattct gcggaagctt ggcattccgg tactgttggt     1740

aaagccacca gcaaaccgcc cagagtagaa gaccggtggc caccatggat tggggcacgc     1800

tgcagacgat cctggggggt gtgaacaaac actccaccag cattggaaag atctggctca     1860

ccgtcctctt catttttcgc attatgatcc tcgttgtggc tgcaaaggag gtgtggggag     1920

atgagcaggc cgactttgtc tgcaacaccc tgcagccagg ctgcaagaac gtgtgctacg     1980

atcactactt ccccatctcc cacatccggc tatgggccct gcagctgatc ttcgtgtcca     2040

cgccagcgct cctagtggcc atgcacgtgg cctaccggag acatgagaag aagaggaagt     2100

tcatcaaggg ggagataaag agtgaattta aggacatcga ggagatcaaa acccagaagg     2160

tccgcatcga aggctccctg tggtggacct acacaagcag catcttcttc cgggtcatct     2220

tcgaagccgc cttcatgtac gtcttctatg tcatgtacga cggcttctcc atgcagcggc     2280

tggtgaagtg caacgcctgg ccttgtccca acactgtgga ctgctttgtg tcccggccca     2340

cggagaagac tgtcttcaca gtgttcatga ttgcagtgtc tggaatttgc atcctgctga     2400

atgtcactga attgtgttat ttgctaatta gatattgttc tgggaagtca aaaaagccag     2460

tttaagagct cgctgatcag cctcgactgt gccttctagt tgccagccat ctgttgtttg     2520

cccctccccc gtgccttcct tgaccctgga aggtgccact cccactgtcc tttcctaata     2580

aaatgaggaa attgcatcgc attgtctgag taggtgtcat tctattctgg ggggtggggt     2640

ggggcaggac agcaaggggg aggattggga agacaatagc aggcatgctg gggatgcggt     2700

gggctctatg gaagcttgaa ttcagctgac gtgcctcgga ccgcctagga ggaaccccta     2760

gtgatggagt tggccactcc ctctctgcgc gctcgctcgc tcactgaggc cgggcgacca     2820

aaggtcgccc gacgcccggg ctttgcccgg gcggcctcag tgagcgagcg agcgcgcaga     2880

gagggagtgg ccaa                                                       2894


<210>  50
<211>  2987
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary construct sequence

<400>  50
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgcccgggc aaagcccggg       60

cgtcgggcga cctttggtcg cccggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcctttgtc gacgcggccg cacgcgtgac attgattatt      180

gactagttat taatagtaat caattacggg gtcattagtt catagcccat atatggagtt      240

ccgcgttaca taacttacgg taaatggccc gcctggctga ccgcccaacg acccccgccc      300

attgacgtca ataatgacgt atgttcccat agtaacgcca atagggactt tccattgacg      360

tcaatgggtg gactatttac ggtaaactgc ccacttggca gtacatcaag tgtatcatat      420

gccaagtacg ccccctattg acgtcaatga cggtaaatgg cccgcctggc attatgccca      480

gtacatgacc ttatgggact ttcctacttg gcagtacatc tacgtattag tcatcgctat      540

taccatgggt cgaggtgagc cccacgttct gcttcactct ccccatctcc cccccctccc      600

cacccccaat tttgtattta tttatttttt aattattttg tgcagcgatg ggggcggggg      660

gggggggggc gcgcgccagg cggggcgggg cggggcgagg ggcggggcgg ggcgaggcgg      720

agaggtgcgg cggcagccaa tcagagcggc gcgctccgaa agtttccttt tatggcgagg      780

cggcggcggc ggcggcccta taaaaagcga agcgcgcggc gggcgggagt cgctgcgttg      840

ccttcgcccc gtgccccgct ccgcgccgcc tcgcgccgcc cgccccggct ctgactgacc      900

gcgttactcc cacaggtgag cgggcgggac ggcccttctc ctccgggctg taattagcgc      960

ttggtttaat gacggctcgt ttcttttctg tggctgcgtg aaagccttaa agggctccgg     1020

gagggccctt tgtgcggggg ggagcggctc ggggggtgcg tgcgtgtgtg tgtgcgtggg     1080

gagcgccgcg tgcggcccgc gctgcccggc ggctgtgagc gctgcgggcg cggcgcgggg     1140

ctttgtgcgc tccgcgtgtg cgcgagggga gcgcggccgg gggcggtgcc ccgcggtgcg     1200

ggggggctgc gaggggaaca aaggctgcgt gcggggtgtg tgcgtggggg ggtgagcagg     1260

gggtgtgggc gcggcggtcg ggctgtaacc cccccctgca cccccctccc cgagttgctg     1320

agcacggccc ggcttcgggt gcggggctcc gtgcggggcg tggcgcgggg ctcgccgtgc     1380

cgggcggggg gtggcggcag gtgggggtgc cgggcggggc ggggccgcct cgggccgggg     1440

agggctcggg ggaggggcgc ggcggccccc ggagcgccgg cggctgtcga ggcgcggcga     1500

gccgcagcca ttgcctttta tggtaatcgt gcgagagggc gcagggactt cctttgtccc     1560

aaatctgtgc ggagccgaaa tctgggaggc gccgccgcac cccctctagc gggcgcgggg     1620

cgaagcggtg cggcgccggc aggaaggaaa tgggcgggga gggccttcgt gcgtcgccgc     1680

gccgccgtcc ccttctccct ctccagcctc ggggctgtcc gcggggggac ggctgccttc     1740

gggggggacg gggcagggcg gggttcggct tctggcgtgt gaccggcggc tctagagcct     1800

ctgctaacca tgttcatgcc ttcttctttt tcctacagct cctgggcaac gtgctggtta     1860

ttgtgaccgg tgccaccatg gattggggca cgctgcagac gatcctgggg ggtgtgaaca     1920

aacactccac cagcattgga aagatctggc tcaccgtcct cttcattttt cgcattatga     1980

tcctcgttgt ggctgcaaag gaggtgtggg gagatgagca ggccgacttt gtctgcaaca     2040

ccctgcagcc aggctgcaag aacgtgtgct acgatcacta cttccccatc tcccacatcc     2100

ggctatgggc cctgcagctg atcttcgtgt ccacgccagc gctcctagtg gccatgcacg     2160

tggcctaccg gagacatgag aagaagagga agttcatcaa gggggagata aagagtgaat     2220

ttaaggacat cgaggagatc aaaacccaga aggtccgcat cgaaggctcc ctgtggtgga     2280

cctacacaag cagcatcttc ttccgggtca tcttcgaagc cgccttcatg tacgtcttct     2340

atgtcatgta cgacggcttc tccatgcagc ggctggtgaa gtgcaacgcc tggccttgtc     2400

ccaacactgt ggactgcttt gtgtcccggc ccacggagaa gactgtcttc acagtgttca     2460

tgattgcagt gtctggaatt tgcatcctgc tgaatgtcac tgaattgtgt tatttgctaa     2520

ttagatattg ttctgggaag tcaaaaaagc cagtttaaga gctcgctgat cagcctcgac     2580

tgtgccttct agttgccagc catctgttgt ttgcccctcc cccgtgcctt ccttgaccct     2640

ggaaggtgcc actcccactg tcctttccta ataaaatgag gaaattgcat cgcattgtct     2700

gagtaggtgt cattctattc tggggggtgg ggtggggcag gacagcaagg gggaggattg     2760

ggaagacaat agcaggcatg ctggggatgc ggtgggctct atggaagctt gaattcagct     2820

gacgtgcctc ggaccgccta ggaggaaccc ctagtgatgg agttggccac tccctctctg     2880

cgcgctcgct cgctcactga ggccgggcga ccaaaggtcg cccgacgccc gggctttgcc     2940

cgggcggcct cagtgagcga gcgagcgcgc agagagggag tggccaa                   2987


<210>  51
<211>  4419
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary construct sequence

<400>  51
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgcccgggc aaagcccggg       60

cgtcgggcga cctttggtcg cccggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcctttgtc gacgcggccg cacgcgtgac attgattatt      180

gactagttat taatagtaat caattacggg gtcattagtt catagcccat atatggagtt      240

ccgcgttaca taacttacgg taaatggccc gcctggctga ccgcccaacg acccccgccc      300

attgacgtca ataatgacgt atgttcccat agtaacgcca atagggactt tccattgacg      360

tcaatgggtg gactatttac ggtaaactgc ccacttggca gtacatcaag tgtatcatat      420

gccaagtacg ccccctattg acgtcaatga cggtaaatgg cccgcctggc attatgccca      480

gtacatgacc ttatgggact ttcctacttg gcagtacatc tacgtattag tcatcgctat      540

taccatgggt cgaggtgagc cccacgttct gcttcactct ccccatctcc cccccctccc      600

cacccccaat tttgtattta tttatttttt aattattttg tgcagcgatg ggggcggggg      660

gggggggggc gcgcgccagg cggggcgggg cggggcgagg ggcggggcgg ggcgaggcgg      720

agaggtgcgg cggcagccaa tcagagcggc gcgctccgaa agtttccttt tatggcgagg      780

cggcggcggc ggcggcccta taaaaagcga agcgcgcggc gggcgggagt cgctgcgttg      840

ccttcgcccc gtgccccgct ccgcgccgcc tcgcgccgcc cgccccggct ctgactgacc      900

gcgttactcc cacaggtgag cgggcgggac ggcccttctc ctccgggctg taattagcgc      960

ttggtttaat gacggctcgt ttcttttctg tggctgcgtg aaagccttaa agggctccgg     1020

gagggccctt tgtgcggggg ggagcggctc ggggggtgcg tgcgtgtgtg tgtgcgtggg     1080

gagcgccgcg tgcggcccgc gctgcccggc ggctgtgagc gctgcgggcg cggcgcgggg     1140

ctttgtgcgc tccgcgtgtg cgcgagggga gcgcggccgg gggcggtgcc ccgcggtgcg     1200

ggggggctgc gaggggaaca aaggctgcgt gcggggtgtg tgcgtggggg ggtgagcagg     1260

gggtgtgggc gcggcggtcg ggctgtaacc cccccctgca cccccctccc cgagttgctg     1320

agcacggccc ggcttcgggt gcggggctcc gtgcggggcg tggcgcgggg ctcgccgtgc     1380

cgggcggggg gtggcggcag gtgggggtgc cgggcggggc ggggccgcct cgggccgggg     1440

agggctcggg ggaggggcgc ggcggccccc ggagcgccgg cggctgtcga ggcgcggcga     1500

gccgcagcca ttgcctttta tggtaatcgt gcgagagggc gcagggactt cctttgtccc     1560

aaatctgtgc ggagccgaaa tctgggaggc gccgccgcac cccctctagc gggcgcgggg     1620

cgaagcggtg cggcgccggc aggaaggaaa tgggcgggga gggccttcgt gcgtcgccgc     1680

gccgccgtcc ccttctccct ctccagcctc ggggctgtcc gcggggggac ggctgccttc     1740

gggggggacg gggcagggcg gggttcggct tctggcgtgt gaccggcggc tctagagcct     1800

ctgctaacca tgttcatgcc ttcttctttt tcctacagct cctgggcaac gtgctggtta     1860

ttgtgaccgg tgccaccatg gattggggca cgctgcagac gatcctgggg ggtgtgaaca     1920

aacactccac cagcattgga aagatctggc tcaccgtcct cttcattttt cgcattatga     1980

tcctcgttgt ggctgcaaag gaggtgtggg gagatgagca ggccgacttt gtctgcaaca     2040

ccctgcagcc aggctgcaag aacgtgtgct acgatcacta cttccccatc tcccacatcc     2100

ggctatgggc cctgcagctg atcttcgtgt ccacgccagc gctcctagtg gccatgcacg     2160

tggcctaccg gagacatgag aagaagagga agttcatcaa gggggagata aagagtgaat     2220

ttaaggacat cgaggagatc aaaacccaga aggtccgcat cgaaggctcc ctgtggtgga     2280

cctacacaag cagcatcttc ttccgggtca tcttcgaagc cgccttcatg tacgtcttct     2340

atgtcatgta cgacggcttc tccatgcagc ggctggtgaa gtgcaacgcc tggccttgtc     2400

ccaacactgt ggactgcttt gtgtcccggc ccacggagaa gactgtcttc acagtgttca     2460

tgattgcagt gtctggaatt tgcatcctgc tgaatgtcac tgaattgtgt tatttgctaa     2520

ttagatattg ttctgggaag tcaaaaaagc cagtttaaga gctccgcatt gcccagttgt     2580

tagattaaga aatagacagc atgagaggga tgaggcaacc cgtgctcagc tgtcaaggct     2640

cagtcgctag catttcccaa cacaaagatt ctgaccttaa atgcaaccat ttgaaacccc     2700

tgtaggcctc aggtgaaact ccagatgcca caatggagcc tctgctcccc taaagcctca     2760

aaacaaaggc ctaattctat gcctgtctta attttctttc acttaagtta gttccactga     2820

gaccccaggc tgttaggggt tattggtgta aggtactttc atattttaaa cagaggatat     2880

cggcatttgt ttctttctct gaggacaaga gaaaaaagcc aggttccaca gaggacacag     2940

agaaggtttg ggtgtcctcc tggggttctt tttgccaact ttccccacgt taaaggtgaa     3000

cattggttct ttcatttgct ttggaagttt taatctctaa cagtggacaa agttaccagt     3060

gccttaaact ctgttacact ttttggaagt gaaaactttg tagtatgata ggttattttg     3120

atgtaaagat gttctggata ccattatatg ttccccctgt ttcagaggct cagattgtaa     3180

tatgtaaatg gtatgtcatt cgctactatg atttaatttg aaatatggtc ttttggttat     3240

gaatactttg cagcacagct gagaggctgt ctgttgtatt cattgtggtc atagcaccta     3300

acaacattgt agcctcaatc gagtgagaca gactagaagt tcctagtgat ggcttatgat     3360

agcaaatggc ctcatgtcaa atatttagat gtaattttgt gtaagaaata cagactggat     3420

gtaccaccaa ctactacctg taatgacagg cctgtccaac acatctccct tttccatgac     3480

tgtggtagcc agcatcggaa agaacgctga tttaaagagg tcgcttggga attttattga     3540

cacagtacca tttaatgggg aggacaaaat ggggcagggg agggagaagt ttctgtcgtt     3600

aaaaacagat ttggaaagac tggactctaa agtctgttga ttaaagatga gctttgtcta     3660

cttcaaaagt ttgtttgctt accccttcag cctccaattt tttaagtgaa aatatagcta     3720

ataacatgtg aaaagaatag aagctaaggt ttagataaat attgagcaga tctataggaa     3780

gattgaacct gaatattgcc attatgcttg acatggtttc caaaaaatgg tactccacat     3840

atttcagtga gggtaagtat tttcctgttg tcaagaatag cattgtaaaa gcattttgta     3900

ataataaaga atagctttaa tgatatgctt gtaactaaaa taattttgta atgtatcaaa     3960

tacatttaaa acattaaaat ataatctcta taataagctg atcagcctcg actgtgcctt     4020

ctagttgcca gccatctgtt gtttgcccct cccccgtgcc ttccttgacc ctggaaggtg     4080

ccactcccac tgtcctttcc taataaaatg aggaaattgc atcgcattgt ctgagtaggt     4140

gtcattctat tctggggggt ggggtggggc aggacagcaa gggggaggat tgggaagaca     4200

atagcaggca tgctggggat gcggtgggct ctatggaagc ttgaattcag ctgacgtgcc     4260

tcggaccgcc taggaggaac ccctagtgat ggagttggcc actccctctc tgcgcgctcg     4320

ctcgctcact gaggccgggc gaccaaaggt cgcccgacgc ccgggctttg cccgggcggc     4380

ctcagtgagc gagcgagcgc gcagagaggg agtggccaa                            4419


<210>  52
<211>  119
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary 5' AAV ITR

<400>  52
ctgcgcgctc gctcgctcac tgaggccgcc cgggcgtcgg gcgacctttg gtcgcccggc       60

ctcagtgagc gagcgagcgc gcagagaggg agtggccaac tccatcacta ggggttcct       119


<210>  53
<211>  130
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary 3' AAV ITR

<400>  53
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg       60

ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc      120

gagcgcgcag                                                             130


<210>  54
<211>  7112
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary Construct Sequence

<400>  54
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggccgcac gcgtggtaag aaacttgccc gagtttacac agctagtaaa      180

tggttgcatt agtcaggaca gctagcctat attacaataa caaccctctc aaatcctaat      240

ggcttaaaac aacagaggtt taatttatac tcattagctg ttcaaggcag gaggctctat      300

tctctaatcc atacagtcac tcaggatcca ggctggtgga gaccctgcca tattgtagcc      360

tcaccattta aaacatgaag aagatagaaa gtgaggagtc atgtaggttt tgttccgttg      420

cctcaggcta ggagtgacag gtcacttcat ctcactcaca gctcactgcc cacaactagt      480

cacttgtgac tgtgcgagtt aagcttctgt gtgtgaagga aggaaaagag aatgggataa      540

aggtgaacat cagcaggctc taccacagta gtttgaacca agacttgagc ctaggtcatg      600

tggcttcaga atctttgctc ttaatcacac taaacagcct ctgtaagtca tctttccttc      660

atccagtgcc taagaacatg cagtccaatg ccctcatcct tcagaagaac ttgagtgaac      720

tcagagaaat tgagtagagt gccacagcat gcccaaggcc acacaccctg aggttggcag      780

taggtcctga gttagagttg tcatttcttg gctcccctgg tagtagtgga aaggtaaggt      840

tttgacatac tagttggatg accacgggca ggtcacttaa attgtctaag catcgtttga      900

cccttgtaag aattaaatga aatagcacct gtaaaagtgt ctgcacggac ttactgctgt      960

tagttttgtt cctttcttcc tgttgtcact gcacttccct gcctgttacc caggccatgc     1020

agaccagcca ggccttcgac ttacagtgcg gataagattc caaatctcca cggctggttt     1080

ccatgctttc ttccaggctt ctgaggaccc tgtgctctgg tttcttctat ttcttttcta     1140

ttacttttct gttactcttg agcacacttg ctggaagcaa tatgcatcca gttctccctc     1200

tcttgcctca ttacactttg cagaacaact ccaatccctt ccaaccaagt agtccctttg     1260

aatttcttgt cacccaagga atctctctga caggggtctt tgttagggtc acaccccagg     1320

agatggttga ttatggctga gtccagcctg gaatgatggg ggttgggggc agcttgggta     1380

gatgactcag taaatcaaac agaacaatga aaggaggtca tgcttgtcca tctgcattat     1440

tgaagacagc cataaatggc cttaccccag agcgggtctg tcacacctgg agagctgatc     1500

tgacctctcc aagacccctg caactgagtg ttctgggatc tgtcctgcaa caagtgcctc     1560

gagatttgta ggtgggggcc cagagggagg gggtctgcag acgaaggggg caggttttgc     1620

ggggcactta gggttctcat aggttgtagt cacgagctcc aagctctgag gacccagagg     1680

ccgggcgcgc tccgcccgcg gcgccgcccc ctccgtaact ttcccagtct ccgagggaag     1740

aggcggggtg tggggtgcgg ttaaaaggcg ccacggcggg agacaggtct caccggtcac     1800

aacctgttgc ggccccgcag cgcccgcgcg ctcctctccc cgactcggag cccctcggcg     1860

gcgcccggcc caggacccgc ctaggagcgc aggagcccca gcgcagagac cccaacgccg     1920

agacccccgc cccggccccg ccgcgcttcc tcccgacgca gtttaggacc cttgttcgcg     1980

aagaggtggt gtgcggctga gacccgcgtc ctcaggacgg ttccatcagt gcctcgatcc     2040

tgccccactg gaggaggaag gcagcccgaa cagcgctcac ctaactaaca gctgctgaga     2100

gctgggttcc gtggccatgc acctgggact gccttgagaa gcgtgagcaa accgcccaga     2160

gtagaagcgc tagccaccat ggattggggc acgctgcaga cgatcctggg gggtgtgaac     2220

aaacactcca ccagcattgg aaagatctgg ctcaccgtcc tcttcatttt tcgcattatg     2280

atcctcgttg tggctgcaaa ggaggtgtgg ggagatgagc aggccgactt tgtctgcaac     2340

accctgcagc caggctgcaa gaacgtgtgc tacgatcact acttccccat ctcccacatc     2400

cggctatggg ccctgcagct gatcttcgtg tccacgccag cgctcctagt ggccatgcac     2460

gtggcctacc ggagacatga gaagaagagg aagttcatca agggggagat aaagagtgaa     2520

tttaaggaca tcgaggagat caaaacccag aaggtccgca tcgaaggctc cctgtggtgg     2580

acctacacaa gcagcatctt cttccgggtc atcttcgaag ccgccttcat gtacgtcttc     2640

tatgtcatgt acgacggctt ctccatgcag cggctggtga agtgcaacgc ctggccttgt     2700

cccaacactg tggactgctt tgtgtcccgg cccacggaga agactgtctt cacagtgttc     2760

atgattgcag tgtctggaat ttgcatcctg ctgaatgtca ctgaattgtg ttatttgcta     2820

attagatatt gttctgggaa gtcaaaaaag ccagttggat cccgggctga ctacaaagac     2880

catgacggtg attataaaga tcatgacatc gactacaagg atgacgatga caagtaagaa     2940

atagacagca tgagagggat gaggcaaccc gtgctcagct gtcaaggctc agtcgctagc     3000

atttcccaac acaaagattc tgaccttaaa tgcaaccatt tgaaacccct gtaggcctca     3060

ggtgaaactc cagatgccac aatggagctc tgctccccta aagcctcaaa acaaaggcct     3120

aattctatgc ctgtcttaat tttctttcac ttaagttagt tccactgaga ccccaggctg     3180

ttaggggtta ttggtgtaag gtactttcat attttaaaca gaggatatcg gcatttgttt     3240

ctttctctga ggacaagaga aaaaagccag gttccacaga ggacacagag aaggtttggg     3300

tgtcctcctg gggttctttt tgccaacttt ccccacgtta aaggtgaaca ttggttcttt     3360

catttgcttt ggaagtttta atctctaaca gtggacaaag ttaccagtgc cttaaactct     3420

gttacacttt ttggaagtga aaactttgta gtatgatagg ttattttgat gtaaagatgt     3480

tctggatacc attatatgtt ccccctgttt cagaggctca gattgtaata tgtaaatggt     3540

atgtcattcg ctactatgat ttaatttgaa atatggtctt ttggttatga atactttgca     3600

gcacagctga gaggctgtct gttgtattca ttgtggtcat agcacctaac aacattgtag     3660

cctcaatcga gtgagacaga ctagaagttc ctagtgatgg cttatgatag caaatggcct     3720

catgtcaaat atttagatgt aattttgtgt aagaaataca gactggatgt accaccaact     3780

actacctgta atgacaggcc tgtccaacac atctcccttt tccatgactg tggtagccag     3840

catcggaaag aacgctgatt taaagaggtc gcttgggaat tttattgaca cagtaccatt     3900

taatggggag gacaaaatgg ggcaggggag ggagaagttt ctgtcgttaa aaacagattt     3960

ggaaagactg gactctaaag tctgttgatt aaagatgagc tttgtctact tcaaaagttt     4020

gtttgcttac cccttcagcc tccaattttt taagtgaaaa tatagctaat aacatgtgaa     4080

aagaatagaa gctaaggttt agataaatat tgagcagatc tataggaaga ttgaacctga     4140

atattgccat tatgcttgac atggtttcca aaaaatggta ctccacatat ttcagtgagg     4200

gtaagtattt tcctgttgtc aagaatagca ttgtaaaagc attttgtaat aataaagaat     4260

agctttaatg atatgcttgt aactaaaata attttgtaat gtatcaaata catttaaaac     4320

attaaaatat aatctctata ataagagctc gctgatcagc ctcgactgtg ccttctagtt     4380

gccagccatc tgttgtttgc ccctcccccg tgccttcctt gaccctggaa ggtgccactc     4440

ccactgtcct ttcctaataa aatgaggaaa ttgcatcgca ttgtctgagt aggtgtcatt     4500

ctattctggg gggtggggtg gggcaggaca gcaaggggga ggattgggaa gacaatagca     4560

ggcatgctgg ggatgcggtg ggctctatgg aagcttgaat tcagctgacg tgcctcggac     4620

cgctaggaac ccctagtgat ggagttggcc actccctctc tgcgcgctcg ctcgctcact     4680

gaggccgggc gaccaaaggt cgcccgacgc ccgggctttg cccgggcggc ctcagtgagc     4740

gagcgagcgc gcagctgcct gcaggggcgc ctgatgcggt attttctcct tacgcatctg     4800

tgcggtattt cacaccgcat acgtcaaagc aaccatagta cgcgccctgt agcggcgcat     4860

taagcgcggc gggtgtggtg gttacgcgca gcgtgaccgc tacacttgcc agcgccctag     4920

cgcccgctcc tttcgctttc ttcccttcct ttctcgccac gttcgccggc tttccccgtc     4980

aagctctaaa tcgggggctc cctttagggt tccgatttag tgctttacgg cacctcgacc     5040

ccaaaaaact tgatttgggt gatggttcac gtagtgggcc atcgccctga tagacggttt     5100

ttcgcccttt gacgttggag tccacgttct ttaatagtgg actcttgttc caaactggaa     5160

caacactcaa ccctatctcg ggctattctt ttgatttata agggattttg ccgatttcgg     5220

cctattggtt aaaaaatgag ctgatttaac aaaaatttaa cgcgaatttt aacaaaatat     5280

taacgtttac aattttatgg tgcactctca gtacaatctg ctctgatgcc gcatagttaa     5340

gccagccccg acacccgcca acacccgctg acgcgccctg acgggcttgt ctgctcccgg     5400

catccgctta cagacaagct gtgaccgtct ccgggagctg catgtgtcag aggttttcac     5460

cgtcatcacc gaaacgcgcg agacgaaagg gcctcgtgat acgcctattt ttataggtta     5520

atgtcatgaa caataaaact gtctgcttac ataaacagta atacaagggg tgttatgagc     5580

catattcaac gggaaacgtc gaggccgcga ttaaattcca acatggatgc tgatttatat     5640

gggtataaat gggctcgcga taatgtcggg caatcaggtg cgacaatcta tcgcttgtat     5700

gggaagcccg atgcgccaga gttgtttctg aaacatggca aaggtagcgt tgccaatgat     5760

gttacagatg agatggtcag actaaactgg ctgacggaat ttatgcctct tccgaccatc     5820

aagcatttta tccgtactcc tgatgatgca tggttactca ccactgcgat ccccggaaaa     5880

acagcattcc aggtattaga agaatatcct gattcaggtg aaaatattgt tgatgcgctg     5940

gcagtgttcc tgcgccggtt gcattcgatt cctgtttgta attgtccttt taacagcgat     6000

cgcgtatttc gtctcgctca ggcgcaatca cgaatgaata acggtttggt tgatgcgagt     6060

gattttgatg acgagcgtaa tggctggcct gttgaacaag tctggaaaga aatgcataaa     6120

cttttgccat tctcaccgga ttcagtcgtc actcatggtg atttctcact tgataacctt     6180

atttttgacg aggggaaatt aataggttgt attgatgttg gacgagtcgg aatcgcagac     6240

cgataccagg atcttgccat cctatggaac tgcctcggtg agttttctcc ttcattacag     6300

aaacggcttt ttcaaaaata tggtattgat aatcctgata tgaataaatt gcagtttcat     6360

ttgatgctcg atgagttttt ctaatctcat gaccaaaatc ccttaacgtg agttttcgtt     6420

ccactgagcg tcagaccccg tagaaaagat caaaggatct tcttgagatc ctttttttct     6480

gcgcgtaatc tgctgcttgc aaacaaaaaa accaccgcta ccagcggtgg tttgtttgcc     6540

ggatcaagag ctaccaactc tttttccgaa ggtaactggc ttcagcagag cgcagatacc     6600

aaatactgtc cttctagtgt agccgtagtt aggccaccac ttcaagaact ctgtagcacc     6660

gcctacatac ctcgctctgc taatcctgtt accagtggct gctgccagtg gcgataagtc     6720

gtgtcttacc gggttggact caagacgata gttaccggat aaggcgcagc ggtcgggctg     6780

aacggggggt tcgtgcacac agcccagctt ggagcgaacg acctacaccg aactgagata     6840

cctacagcgt gagctatgag aaagcgccac gcttcccgaa gggagaaagg cggacaggta     6900

tccggtaagc ggcagggtcg gaacaggaga gcgcacgagg gagcttccag ggggaaacgc     6960

ctggtatctt tatagtcctg tcgggtttcg ccacctctga cttgagcgtc gatttttgtg     7020

atgctcgtca ggggggcgga gcctatggaa aaacgccagc aacgcggcct ttttacggtt     7080

cctggccttt tgctggcctt ttgctcacat gt                                   7112


<210>  55
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary synthetic barcode B

<400>  55
cacaacct                                                                 8


<210>  56

<400>  56
000

<210>  57
<211>  1513
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary IGFBP2 promoter

<400>  57
aagaaacttg cccgagttta cacagctagt aaatggttgc attagtcagg acagctagcc       60

tatattacaa taacaaccct ctcaaatcct aatggcttaa aacaacagag gtttaattta      120

tactcattag ctgttcaagg caggaggctc tattctctaa tccatacagt cactcaggat      180

ccaggctggt ggagaccctg ccatattgta gcctcaccat ttaaaacatg aagaagatag      240

aaagtgagga gtcatgtagg ttttgttccg ttgcctcagg ctaggagtga caggtcactt      300

catctcactc acagctcact gcccacaact agtcacttgt gactgtgcga gttaagcttc      360

tgtgtgtgaa ggaaggaaaa gagaatggga taaaggtgaa catcagcagg ctctaccaca      420

gtagtttgaa ccaagacttg agcctaggtc atgtggcttc agaatctttg ctcttaatca      480

cactaaacag cctctgtaag tcatctttcc ttcatccagt gcctaagaac atgcagtcca      540

atgccctcat ccttcagaag aacttgagtg aactcagaga aattgagtag agtgccacag      600

catgcccaag gccacacacc ctgaggttgg cagtaggtcc tgagttagag ttgtcatttc      660

ttggctcccc tggtagtagt ggaaaggtaa ggttttgaca tactagttgg atgaccacgg      720

gcaggtcact taaattgtct aagcatcgtt tgacccttgt aagaattaaa tgaaatagca      780

cctgtaaaag tgtctgcacg gacttactgc tgttagtttt gttcctttct tcctgttgtc      840

actgcacttc cctgcctgtt acccaggcca tgcagaccag ccaggccttc gacttacagt      900

gcggataaga ttccaaatct ccacggctgg tttccatgct ttcttccagg cttctgagga      960

ccctgtgctc tggtttcttc tatttctttt ctattacttt tctgttactc ttgagcacac     1020

ttgctggaag caatatgcat ccagttctcc ctctcttgcc tcattacact ttgcagaaca     1080

actccaatcc cttccaacca agtagtccct ttgaatttct tgtcacccaa ggaatctctc     1140

tgacaggggt ctttgttagg gtcacacccc aggagatggt tgattatggc tgagtccagc     1200

ctggaatgat gggggttggg ggcagcttgg gtagatgact cagtaaatca aacagaacaa     1260

tgaaaggagg tcatgcttgt ccatctgcat tattgaagac agccataaat ggccttaccc     1320

cagagcgggt ctgtcacacc tggagagctg atctgacctc tccaagaccc ctgcaactga     1380

gtgttctggg atctgtcctg caacaagtgc ctcgagattt gtaggtgggg gcccagaggg     1440

agggggtctg cagacgaagg gggcaggttt tgcggggcac ttagggttct cataggttgt     1500

agtcacgagc tcc                                                        1513


<210>  58
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary Taqman probe for quantification of constructs

<400>  58
tctggctcac cgtcctcttc attt                                              24


<210>  59
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary forward qPCR primer for quantification of constructs

<400>  59
caaacactcc accagcattg                                                   20


<210>  60
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary reverse qPCR primer for quantification of constructs

<400>  60
cagccacaac gaggatcata                                                   20


<210>  61
<211>  6787
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary Construct Sequence

<400>  61
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggccgcac gcgtggtcca caggtaactc cgtcggcgtc cacagggggg      180

caggagatac catactgcac agttgtacgt cttccatctg tttggtgtag aaaaatctaa      240

ccactacaag aatgccacgg gcactgtggc agacagaagc agcgctacgc cgcatcgcct      300

ttcagcgtgc aggcccagga atgagcgagg cagtgggcgg ggaagacagg cacggggaat      360

ctggggacag ataaaggaaa ctcgtgatgg ggcgaggctg ggctgaagag aaacagattg      420

gggtagagct gcaaagggag gggtccactg gaaggcgagg ggggaggccg ggaagagaga      480

gggtgggaag gcagtgtgag atgggagggc agtgtgagaa gaaaagcagg ctggggaaga      540

gggattggaa tgcagaagga acttggggaa ggaggaagtc ctgcaggcgg gagggaaaga      600

agagaggggg agcagctaaa gtctgcgtca gaagaggttg gggactgcga gaggagaggc      660

tggggcctgc aggggagcgc agcagctttt agcatcgatc caaactctaa agactcgtgg      720

cctttgcctg acctcgaggg tcgggaatag acgcctgtct ttgtggagag cgatacccaa      780

ccgagaaaat ggggctgttc cgagctgggc cctgcgcctg gcccagggcg aggcttctct      840

ggctccgggc tggcccctga ggggcagcac gcagcctgca gcagaggcgc ctgctccaag      900

ctgtctcttg ggggcgccgc cgccgcttcc ctcctccggg gccgctcgct cccaggaaag      960

tggaggcggc tggcgaggac cgagagccgg ggccgcgctg cggagggacc acacctccgg     1020

gagttcgagg gggaccctgg cgcggcgggc cagcctttcg ggccggcagc gcccgccttc     1080

ccccggtcag cgcttgcggc ccgcgccgcg cgcaccgccc ggcaaccccg cgcgcgtccc     1140

gcgggggcgc tgcgtcttcc tgccacaccg gcgcaccgcg gcccctctcc cccacacctc     1200

cggcccgcac cacccggctc tcctcccacc ctccccaccc ctcctctgcc ctccctcccc     1260

attcctcccc tcccggcgag gggcgggagg gggcgtggcg gggccggggt ttgtgtggct     1320

gggacccggc tcctcaagct ctgaggaccc agaggccggg cgcgctccgc ccgcggcgcc     1380

gccccctccg taactttccc agtctccgag ggaagaggcg gggtgtgggg tgcggttaaa     1440

aggcgccacg gcgggagaca ggtctcaccg gtgtgtcacc gttgcggccc cgcagcgccc     1500

gcgcgctcct ctccccgact cggagcccct cggcggcgcc cggcccagga cccgcctagg     1560

agcgcaggag ccccagcgca gagaccccaa cgccgagacc cccgccccgg ccccgccgcg     1620

cttcctcccg acgcagttta ggacccttgt tcgcgaagag gtggtgtgcg gctgagaccc     1680

gcgtcctcag gacggttcca tcagtgcctc gatcctgccc cactggagga ggaaggcagc     1740

ccgaacagcg ctcacctaac taacagctgc tgagagctgg gttccgtggc catgcacctg     1800

ggactgcctt gagaagcgtg agcaaaccgc ccagagtaga agcgctagcc accatggatt     1860

ggggcacgct gcagacgatc ctggggggtg tgaacaaaca ctccaccagc attggaaaga     1920

tctggctcac cgtcctcttc atttttcgca ttatgatcct cgttgtggct gcaaaggagg     1980

tgtggggaga tgagcaggcc gactttgtct gcaacaccct gcagccaggc tgcaagaacg     2040

tgtgctacga tcactacttc cccatctccc acatccggct atgggccctg cagctgatct     2100

tcgtgtccac gccagcgctc ctagtggcca tgcacgtggc ctaccggaga catgagaaga     2160

agaggaagtt catcaagggg gagataaaga gtgaatttaa ggacatcgag gagatcaaaa     2220

cccagaaggt ccgcatcgaa ggctccctgt ggtggaccta cacaagcagc atcttcttcc     2280

gggtcatctt cgaagccgcc ttcatgtacg tcttctatgt catgtacgac ggcttctcca     2340

tgcagcggct ggtgaagtgc aacgcctggc cttgtcccaa cactgtggac tgctttgtgt     2400

cccggcccac ggagaagact gtcttcacag tgttcatgat tgcagtgtct ggaatttgca     2460

tcctgctgaa tgtcactgaa ttgtgttatt tgctaattag atattgttct gggaagtcaa     2520

aaaagccagt tggatcccgg gctgactaca aagaccatga cggtgattat aaagatcatg     2580

acatcgacta caaggatgac gatgacaagt aagaaataga cagcatgaga gggatgaggc     2640

aacccgtgct cagctgtcaa ggctcagtcg ctagcatttc ccaacacaaa gattctgacc     2700

ttaaatgcaa ccatttgaaa cccctgtagg cctcaggtga aactccagat gccacaatgg     2760

agctctgctc ccctaaagcc tcaaaacaaa ggcctaattc tatgcctgtc ttaattttct     2820

ttcacttaag ttagttccac tgagacccca ggctgttagg ggttattggt gtaaggtact     2880

ttcatatttt aaacagagga tatcggcatt tgtttctttc tctgaggaca agagaaaaaa     2940

gccaggttcc acagaggaca cagagaaggt ttgggtgtcc tcctggggtt ctttttgcca     3000

actttcccca cgttaaaggt gaacattggt tctttcattt gctttggaag ttttaatctc     3060

taacagtgga caaagttacc agtgccttaa actctgttac actttttgga agtgaaaact     3120

ttgtagtatg ataggttatt ttgatgtaaa gatgttctgg ataccattat atgttccccc     3180

tgtttcagag gctcagattg taatatgtaa atggtatgtc attcgctact atgatttaat     3240

ttgaaatatg gtcttttggt tatgaatact ttgcagcaca gctgagaggc tgtctgttgt     3300

attcattgtg gtcatagcac ctaacaacat tgtagcctca atcgagtgag acagactaga     3360

agttcctagt gatggcttat gatagcaaat ggcctcatgt caaatattta gatgtaattt     3420

tgtgtaagaa atacagactg gatgtaccac caactactac ctgtaatgac aggcctgtcc     3480

aacacatctc ccttttccat gactgtggta gccagcatcg gaaagaacgc tgatttaaag     3540

aggtcgcttg ggaattttat tgacacagta ccatttaatg gggaggacaa aatggggcag     3600

gggagggaga agtttctgtc gttaaaaaca gatttggaaa gactggactc taaagtctgt     3660

tgattaaaga tgagctttgt ctacttcaaa agtttgtttg cttacccctt cagcctccaa     3720

ttttttaagt gaaaatatag ctaataacat gtgaaaagaa tagaagctaa ggtttagata     3780

aatattgagc agatctatag gaagattgaa cctgaatatt gccattatgc ttgacatggt     3840

ttccaaaaaa tggtactcca catatttcag tgagggtaag tattttcctg ttgtcaagaa     3900

tagcattgta aaagcatttt gtaataataa agaatagctt taatgatatg cttgtaacta     3960

aaataatttt gtaatgtatc aaatacattt aaaacattaa aatataatct ctataataag     4020

agctcgctga tcagcctcga ctgtgccttc tagttgccag ccatctgttg tttgcccctc     4080

ccccgtgcct tccttgaccc tggaaggtgc cactcccact gtcctttcct aataaaatga     4140

ggaaattgca tcgcattgtc tgagtaggtg tcattctatt ctggggggtg gggtggggca     4200

ggacagcaag ggggaggatt gggaagacaa tagcaggcat gctggggatg cggtgggctc     4260

tatggaagct tgaattcagc tgacgtgcct cggaccgcta ggaaccccta gtgatggagt     4320

tggccactcc ctctctgcgc gctcgctcgc tcactgaggc cgggcgacca aaggtcgccc     4380

gacgcccggg ctttgcccgg gcggcctcag tgagcgagcg agcgcgcagc tgcctgcagg     4440

ggcgcctgat gcggtatttt ctccttacgc atctgtgcgg tatttcacac cgcatacgtc     4500

aaagcaacca tagtacgcgc cctgtagcgg cgcattaagc gcggcgggtg tggtggttac     4560

gcgcagcgtg accgctacac ttgccagcgc cctagcgccc gctcctttcg ctttcttccc     4620

ttcctttctc gccacgttcg ccggctttcc ccgtcaagct ctaaatcggg ggctcccttt     4680

agggttccga tttagtgctt tacggcacct cgaccccaaa aaacttgatt tgggtgatgg     4740

ttcacgtagt gggccatcgc cctgatagac ggtttttcgc cctttgacgt tggagtccac     4800

gttctttaat agtggactct tgttccaaac tggaacaaca ctcaacccta tctcgggcta     4860

ttcttttgat ttataaggga ttttgccgat ttcggcctat tggttaaaaa atgagctgat     4920

ttaacaaaaa tttaacgcga attttaacaa aatattaacg tttacaattt tatggtgcac     4980

tctcagtaca atctgctctg atgccgcata gttaagccag ccccgacacc cgccaacacc     5040

cgctgacgcg ccctgacggg cttgtctgct cccggcatcc gcttacagac aagctgtgac     5100

cgtctccggg agctgcatgt gtcagaggtt ttcaccgtca tcaccgaaac gcgcgagacg     5160

aaagggcctc gtgatacgcc tatttttata ggttaatgtc atgaacaata aaactgtctg     5220

cttacataaa cagtaataca aggggtgtta tgagccatat tcaacgggaa acgtcgaggc     5280

cgcgattaaa ttccaacatg gatgctgatt tatatgggta taaatgggct cgcgataatg     5340

tcgggcaatc aggtgcgaca atctatcgct tgtatgggaa gcccgatgcg ccagagttgt     5400

ttctgaaaca tggcaaaggt agcgttgcca atgatgttac agatgagatg gtcagactaa     5460

actggctgac ggaatttatg cctcttccga ccatcaagca ttttatccgt actcctgatg     5520

atgcatggtt actcaccact gcgatccccg gaaaaacagc attccaggta ttagaagaat     5580

atcctgattc aggtgaaaat attgttgatg cgctggcagt gttcctgcgc cggttgcatt     5640

cgattcctgt ttgtaattgt ccttttaaca gcgatcgcgt atttcgtctc gctcaggcgc     5700

aatcacgaat gaataacggt ttggttgatg cgagtgattt tgatgacgag cgtaatggct     5760

ggcctgttga acaagtctgg aaagaaatgc ataaactttt gccattctca ccggattcag     5820

tcgtcactca tggtgatttc tcacttgata accttatttt tgacgagggg aaattaatag     5880

gttgtattga tgttggacga gtcggaatcg cagaccgata ccaggatctt gccatcctat     5940

ggaactgcct cggtgagttt tctccttcat tacagaaacg gctttttcaa aaatatggta     6000

ttgataatcc tgatatgaat aaattgcagt ttcatttgat gctcgatgag tttttctaat     6060

ctcatgacca aaatccctta acgtgagttt tcgttccact gagcgtcaga ccccgtagaa     6120

aagatcaaag gatcttcttg agatcctttt tttctgcgcg taatctgctg cttgcaaaca     6180

aaaaaaccac cgctaccagc ggtggtttgt ttgccggatc aagagctacc aactcttttt     6240

ccgaaggtaa ctggcttcag cagagcgcag ataccaaata ctgtccttct agtgtagccg     6300

tagttaggcc accacttcaa gaactctgta gcaccgccta catacctcgc tctgctaatc     6360

ctgttaccag tggctgctgc cagtggcgat aagtcgtgtc ttaccgggtt ggactcaaga     6420

cgatagttac cggataaggc gcagcggtcg ggctgaacgg ggggttcgtg cacacagccc     6480

agcttggagc gaacgaccta caccgaactg agatacctac agcgtgagct atgagaaagc     6540

gccacgcttc ccgaagggag aaaggcggac aggtatccgg taagcggcag ggtcggaaca     6600

ggagagcgca cgagggagct tccaggggga aacgcctggt atctttatag tcctgtcggg     6660

tttcgccacc tctgacttga gcgtcgattt ttgtgatgct cgtcaggggg gcggagccta     6720

tggaaaaacg ccagcaacgc ggccttttta cggttcctgg ccttttgctg gccttttgct     6780

cacatgt                                                               6787


<210>  62
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic barcode A

<400>  62
gtgtcacc                                                                 8


<210>  63
<211>  382
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary CMV enhancer

<400>  63
gacattgatt attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc       60

catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca      120

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga      180

ctttccattg acgtcaatgg gtggactatt tacggtaaac tgcccacttg gcagtacatc      240

aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct      300

ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat      360

tagtcatcgc tattaccatg gt                                               382


<210>  64
<211>  245
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary chimeric intron

<400>  64
ggagtcgctg cgttgccttc gccccgtgcc ccgctccgcg ccgcctcgcg ccgcccgccc       60

cggctctgac tgaccgcgtt actcccacag gtgagcgggc gggacggccc ttctcctccg      120

ggctgtaatt agcgcttggt ttaatgacgg cttgtttctt ttctgtggct gcgtgaaagc      180

cttgaggggc tccgggagct agagcctctg ctaaccatgt tcatgccttc ttctttttcc      240

tacag                                                                  245


<210>  65
<211>  1044
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary GJB2 enhancer

<400>  65
cttcttctgg agtcttttct ggaataattc tgggagtggg ctcagcctgc gggagagtaa       60

catttttata acttgataga tgtagctgag atgcctccca gaggggagac ccgcctctcc      120

tccggcagct gtgcacgtag gcttgttccc agcagcctgg ccagggtggt ccacctggtg      180

tttctcatct tctttccccg gagcgctgac tcctgcgcgt cctcttggaa gactcttgac      240

aggacgggtg ttttatgggt gtgattcagt gtcctcttgc atcagttcaa tgtggtggtg      300

ttcaatcaac ccttgtagcg ttagcaaaat ttgctcaagt cattccgcag gaatgtctgt      360

gtcttgcttc caagaaagct tgtaagtgcc ggcaacaggc caagcagctc acaaacctga      420

ccacaagcct gtgagtaatt gtggggcagc acttagcagt cttttatttt cgacttatta      480

aagtctcatc ttggcctcac cttctccctg gaaggtggcg tgggtgggaa ccactgggtc      540

agatcttttt cacccttgcc gtggagccag tttcctgttg catgtggggg aagcaacatg      600

tggtgaagag tatagaaaac gaaaacatgt gggtacagta tgtataagtg gagggaacaa      660

actcataatt ccaactagtt tctcatgaga gactcatgaa tcattgtggt agttctcaat      720

ataaacttaa tctaggccgg atgtggtggc tcacacctgt aatctcagca ctctgggtgg      780

atcacttgag gtcaggagtt tgagaccagt ctgaccaaca tggagaaacc ccatcgctac      840

taaaaataca aaattatcca gatgtggtgg ctcacacctg taatcccagc actttgggag      900

gctgaggcgg gtggatcact tgaggtcagg agtttgagac cagcctgacc aacatggaga      960

aactgtgtct ctactaaaaa tacaaaatta gctgggcgtg gtgacgcatg cctgtaatcc     1020

cagctatttg gaggccgaag cagg                                            1044


<210>  66
<211>  362
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary 5' UTR Sequence

<400>  66
gttgcggccc cgcagcgccc gcgcgctcct ctccccgact cggagcccct cggcggcgcc       60

cggcccagga cccgcctagg agcgcaggag ccccagcgca gagaccccaa cgccgagacc      120

cccgccccgg ccccgccgcg cttcctcccg acgcagttta ggacccttgt tcgcgaagag      180

gtggtgtgcg gctgagaccc gcgtcctcag gacggttcca tcagtgcctc gatcctgccc      240

cactggagga ggaaggcagc ccgaacagcg ctcacctaac taacagctgc tgagagctgg      300

gttccgtggc catgcacctg ggactgcctt gagaagcgtg agcaaaccgc ccagagtaga      360

ag                                                                     362


<210>  67
<211>  1407
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary 3' UTR Sequence

<400>  67
gaaatagaca gcatgagagg gatgaggcaa cccgtgctca gctgtcaagg ctcagtcgct       60

agcatttccc aacacaaaga ttctgacctt aaatgcaacc atttgaaacc cctgtaggcc      120

tcaggtgaaa ctccagatgc cacaatggag ctctgctccc ctaaagcctc aaaacaaagg      180

cctaattcta tgcctgtctt aattttcttt cacttaagtt agttccactg agaccccagg      240

ctgttagggg ttattggtgt aaggtacttt catattttaa acagaggata tcggcatttg      300

tttctttctc tgaggacaag agaaaaaagc caggttccac agaggacaca gagaaggttt      360

gggtgtcctc ctggggttct ttttgccaac tttccccacg ttaaaggtga acattggttc      420

tttcatttgc tttggaagtt ttaatctcta acagtggaca aagttaccag tgccttaaac      480

tctgttacac tttttggaag tgaaaacttt gtagtatgat aggttatttt gatgtaaaga      540

tgttctggat accattatat gttccccctg tttcagaggc tcagattgta atatgtaaat      600

ggtatgtcat tcgctactat gatttaattt gaaatatggt cttttggtta tgaatacttt      660

gcagcacagc tgagaggctg tctgttgtat tcattgtggt catagcacct aacaacattg      720

tagcctcaat cgagtgagac agactagaag ttcctagtga tggcttatga tagcaaatgg      780

cctcatgtca aatatttaga tgtaattttg tgtaagaaat acagactgga tgtaccacca      840

actactacct gtaatgacag gcctgtccaa cacatctccc ttttccatga ctgtggtagc      900

cagcatcgga aagaacgctg atttaaagag gtcgcttggg aattttattg acacagtacc      960

atttaatggg gaggacaaaa tggggcaggg gagggagaag tttctgtcgt taaaaacaga     1020

tttggaaaga ctggactcta aagtctgttg attaaagatg agctttgtct acttcaaaag     1080

tttgtttgct taccccttca gcctccaatt ttttaagtga aaatatagct aataacatgt     1140

gaaaagaata gaagctaagg tttagataaa tattgagcag atctatagga agattgaacc     1200

tgaatattgc cattatgctt gacatggttt ccaaaaaatg gtactccaca tatttcagtg     1260

agggtaagta ttttcctgtt gtcaagaata gcattgtaaa agcattttgt aataataaag     1320

aatagcttta atgatatgct tgtaactaaa ataattttgt aatgtatcaa atacatttaa     1380

aacattaaaa tataatctct ataataa                                         1407


<210>  68
<211>  1248
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary 3' UTR Sequence

<400>  68
cgcattgccc agttgttaga ttaagaaata gacagcatga gagggatgag gcaacccgtg       60

ctcagctgtc aaggctcagt cgctagcatt tcccaacaca aagattctga ccttaaatgc      120

aaccatttga aacccctgta ggcctcaggt gaaactccag atgccacaat ggagcctctg      180

ctcccctaaa gcctcaaaac aaaggcctaa ttctatgcct gtcttaattt tctttcactt      240

aagttagttc cactgagacc ccaggctgtt aggggttatt ggtgtaaggt actttcatat      300

tttaaacaga ggatatcggc atttgtttct ttctctgagg acaagagaaa aaagccaggt      360

tccacagagg acacagagaa ggtttgggtg tcctcctggg gttctttttg ccaactttcc      420

ccacgttaaa ggtgaacatt ggttctttca tttgctttgg aagttttaat ctctaacagt      480

ggacaaagtt accagtgcct taaactctgt tacacttttt ggaagtgaaa actttgtagt      540

atgataggtt attttgatgt aaagatgttc tggataccat tatatgttcc ccctgtttca      600

gaggctcaga ttgtaatatg taaatggtat gtcattcgct actatgattt aatttgaaat      660

atggtctttt ggttatgaat actttgcagc acagctgaga ggctgtctgt tgtattcatt      720

gtggtcatag cacctaacaa cattgtagcc tcaatcgagt gagacagact agaagttcct      780

agtgatggct tatgatagca aatggcctca tgtcaaatat ttagatgtaa ttttgtgtaa      840

gaaatacaga ctggatgtac caccaactac tacctgtaat gacaggcctg tccaacacat      900

ctcccttttc catgactgtg gtagccagca tcggaaagaa cgctgattta aagaggtcgc      960

ttgggaattt tattgacaca gtaccattta atggggagga caaaatgggg caggggaggg     1020

agaagtttct gtcgttaaaa acagatttgg aaagactgga ctctaaagtc tgttgattaa     1080

agatgagctt tgtctacttc aaaagtttgt ttgcttaccc cttcagcctc caatttttta     1140

agtgaaaata tagctaataa catgtgaaaa gaatagaagc taaggtttag ataaatattg     1200

agcagatcta taggaagatt gaacctgaat attgccatta tgcttgac                  1248


<210>  69
<211>  1372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary 3' UTR Sequence

<400>  69
gagctcagtg tgagttctac cattgccaaa ctcgagcagt gaattctacc agtgccatag       60

gatccagtgt gagttctacc attgccaaag gtacccagtg aattctacca gtgccatagt      120

taaccgcatt gcccagttgt tagattaaga aatagacagc atgagaggga tgaggcaacc      180

cgtgctcagc tgtcaaggct cagtcgctag catttcccaa cacaaagatt ctgaccttaa      240

atgcaaccat ttgaaacccc tgtaggcctc aggtgaaact ccagatgcca caatggagcc      300

tctgctcccc taaagcctca aaacaaaggc ctaattctat gcctgtctta attttctttc      360

acttaagtta gttccactga gaccccaggc tgttaggggt tattggtgta aggtactttc      420

atattttaaa cagaggatat cggcatttgt ttctttctct gaggacaaga gaaaaaagcc      480

aggttccaca gaggacacag agaaggtttg ggtgtcctcc tggggttctt tttgccaact      540

ttccccacgt taaaggtgaa cattggttct ttcatttgct ttggaagttt taatctctaa      600

cagtggacaa agttaccagt gccttaaact ctgttacact ttttggaagt gaaaactttg      660

tagtatgata ggttattttg atgtaaagat gttctggata ccattatatg ttccccctgt      720

ttcagaggct cagattgtaa tatgtaaatg gtatgtcatt cgctactatg atttaatttg      780

aaatatggtc ttttggttat gaatactttg cagcacagct gagaggctgt ctgttgtatt      840

cattgtggtc atagcaccta acaacattgt agcctcaatc gagtgagaca gactagaagt      900

tcctagtgat ggcttatgat agcaaatggc ctcatgtcaa atatttagat gtaattttgt      960

gtaagaaata cagactggat gtaccaccaa ctactacctg taatgacagg cctgtccaac     1020

acatctccct tttccatgac tgtggtagcc agcatcggaa agaacgctga tttaaagagg     1080

tcgcttggga attttattga cacagtacca tttaatgggg aggacaaaat ggggcagggg     1140

agggagaagt ttctgtcgtt aaaaacagat ttggaaagac tggactctaa agtctgttga     1200

ttaaagatga gctttgtcta cttcaaaagt ttgtttgctt accccttcag cctccaattt     1260

tttaagtgaa aatatagcta ataacatgtg aaaagaatag aagctaaggt ttagataaat     1320

attgagcaga tctataggaa gattgaacct gaatattgcc attatgcttg ac             1372


<210>  70
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary cloning site J

<400>  70
gcggccgcac gcgt                                                         14


<210>  71
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary cloning site K

<400>  71
gcggccgcac gcgtggt                                                      17


<210>  72
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary cloning site L

<400>  72
ctcctgggca acgtgctggt tattgtgacc ggt                                    33


<210>  73
<211>  11
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary cloning site M

<400>  73
cgctagccac c                                                            11


<210>  74
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary cloning site N

<400>  74
accggtcgct agccacc                                                      17


<210>  75
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary cloning site O

<400>  75
gagctcgctg atcagcctcg a                                                 21


<210>  76
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary cloning site P

<400>  76
aagcttgaat tcagctgacg tgcctcggac cgct                                   34


<210>  77
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  77
ggatcccggg ct                                                           12


<210>  78
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary mRNA destabilizing domain sequence

<400>  78
agtgtgagtt ctaccattgc caaa                                              24


<210>  79
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary mRNA destabilizing domain sequence

<400>  79
agtgaattct accagtgcca ta                                                22


<210>  80
<211>  124
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary mRNA destabilizing domain sequence

<400>  80
gagctcagtg tgagttctac cattgccaaa ctcgagcagt gaattctacc agtgccatag       60

gatccagtgt gagttctacc attgccaaag gtacccagtg aattctacca gtgccatagt      120

taac                                                                   124


<210>  81
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary 3xFLAG tag sequence with stop codon

<400>  81
gactacaaag accatgacgg tgattataaa gatcatgaca tcgactacaa ggatgacgat       60

gacaagtaa                                                               69


<210>  82
<211>  4786
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary construct sequence

<400>  82
ctgcgcgctc gctcgctcac tgaggccgcc cgggcgtcgg gcgacctttg gtcgcccggc       60

ctcagtgagc gagcgagcgc gcagagaggg agtggccaac tccatcacta ggggttcctg      120

cggccgcacg cgtgacattg attattgact agttattaat agtaatcaat tacggggtca      180

ttagttcata gcccatatat ggagttccgc gttacataac ttacggtaaa tggcccgcct      240

ggctgaccgc ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt tcccatagta      300

acgccaatag ggactttcca ttgacgtcaa tgggtggact atttacggta aactgcccac      360

ttggcagtac atcaagtgta tcatatgcca agtacgcccc ctattgacgt caatgacggt      420

aaatggcccg cctggcatta tgcccagtac atgaccttat gggactttcc tacttggcag      480

tacatctacg tattagtcat cgctattacc atgggtcgag gtgagcccca cgttctgctt      540

cactctcccc atctcccccc cctccccacc cccaattttg tatttattta ttttttaatt      600

attttgtgca gcgatggggg cggggggggg gggggcgcgc gccaggcggg gcggggcggg      660

gcgaggggcg gggcggggcg aggcggagag gtgcggcggc agccaatcag agcggcgcgc      720

tccgaaagtt tccttttatg gcgaggcggc ggcggcggcg gccctataaa aagcgaagcg      780

cgcggcgggc gggagtcgct gcgttgcctt cgccccgtgc cccgctccgc gccgcctcgc      840

gccgcccgcc ccggctctga ctgaccgcgt tactcccaca ggtgagcggg cgggacggcc      900

cttctcctcc gggctgtaat tagcgcttgg tttaatgacg gctcgtttct tttctgtggc      960

tgcgtgaaag ccttaaaggg ctccgggagg gccctttgtg cgggggggag cggctcgggg     1020

ggtgcgtgcg tgtgtgtgtg cgtggggagc gccgcgtgcg gcccgcgctg cccggcggct     1080

gtgagcgctg cgggcgcggc gcggggcttt gtgcgctccg cgtgtgcgcg aggggagcgc     1140

ggccgggggc ggtgccccgc ggtgcggggg ggctgcgagg ggaacaaagg ctgcgtgcgg     1200

ggtgtgtgcg tgggggggtg agcagggggt gtgggcgcgg cggtcgggct gtaacccccc     1260

cctgcacccc cctccccgag ttgctgagca cggcccggct tcgggtgcgg ggctccgtgc     1320

ggggcgtggc gcggggctcg ccgtgccggg cggggggtgg cggcaggtgg gggtgccggg     1380

cggggcgggg ccgcctcggg ccggggaggg ctcgggggag gggcgcggcg gcccccggag     1440

cgccggcggc tgtcgaggcg cggcgagccg cagccattgc cttttatggt aatcgtgcga     1500

gagggcgcag ggacttcctt tgtcccaaat ctgtgcggag ccgaaatctg ggaggcgccg     1560

ccgcaccccc tctagcgggc gcggggcgaa gcggtgcggc gccggcagga aggaaatggg     1620

cggggagggc cttcgtgcgt cgccgcgccg ccgtcccctt ctccctctcc agcctcgggg     1680

ctgtccgcgg ggggacggct gccttcgggg gggacggggc agggcggggt tcggcttctg     1740

gcgtgtgacc ggcggctcta gagcctctgc taaccatgtt catgccttct tctttttcct     1800

acagctcctg ggcaacgtgc tggttattgt gaccggtgtt gcggccccgc agcgcccgcg     1860

cgctcctctc cccgactcgg agcccctcgg cggcgcccgg cccaggaccc gcctaggagc     1920

gcaggagccc cagcgcagag accccaacgc cgagaccccc gccccggccc cgccgcgctt     1980

cctcccgacg cagtttagga cccttgttcg cgaagaggtg gtgtgcggct gagacccgcg     2040

tcctcaggac ggttccatca gtgcctcgat cctgccccac tggaggagga aggcagcccg     2100

aacagcgctc acctaactaa cagctgctga gagctgggtt ccgtggccat gcacctggga     2160

ctgccttgag aagcgtgagc aaaccgccca gagtagaagc gctagccacc atggattggg     2220

gcacgctgca gacgatcctg gggggtgtga acaaacactc caccagcatt ggaaagatct     2280

ggctcaccgt cctcttcatt tttcgcatta tgatcctcgt tgtggctgca aaggaggtgt     2340

ggggagatga gcaggccgac tttgtctgca acaccctgca gccaggctgc aagaacgtgt     2400

gctacgatca ctacttcccc atctcccaca tccggctatg ggccctgcag ctgatcttcg     2460

tgtccacgcc agcgctccta gtggccatgc acgtggccta ccggagacat gagaagaaga     2520

ggaagttcat caagggggag ataaagagtg aatttaagga catcgaggag atcaaaaccc     2580

agaaggtccg catcgaaggc tccctgtggt ggacctacac aagcagcatc ttcttccggg     2640

tcatcttcga agccgccttc atgtacgtct tctatgtcat gtacgacggc ttctccatgc     2700

agcggctggt gaagtgcaac gcctggcctt gtcccaacac tgtggactgc tttgtgtccc     2760

ggcccacgga gaagactgtc ttcacagtgt tcatgattgc agtgtctgga atttgcatcc     2820

tgctgaatgt cactgaattg tgttatttgc taattagata ttgttctggg aagtcaaaaa     2880

agccagttgg atcccgggct gactacaaag accatgacgg tgattataaa gatcatgaca     2940

tcgactacaa ggatgacgat gacaagtaag aaatagacag catgagaggg atgaggcaac     3000

ccgtgctcag ctgtcaaggc tcagtcgcta gcatttccca acacaaagat tctgacctta     3060

aatgcaacca tttgaaaccc ctgtaggcct caggtgaaac tccagatgcc acaatggagc     3120

tctgctcccc taaagcctca aaacaaaggc ctaattctat gcctgtctta attttctttc     3180

acttaagtta gttccactga gaccccaggc tgttaggggt tattggtgta aggtactttc     3240

atattttaaa cagaggatat cggcatttgt ttctttctct gaggacaaga gaaaaaagcc     3300

aggttccaca gaggacacag agaaggtttg ggtgtcctcc tggggttctt tttgccaact     3360

ttccccacgt taaaggtgaa cattggttct ttcatttgct ttggaagttt taatctctaa     3420

cagtggacaa agttaccagt gccttaaact ctgttacact ttttggaagt gaaaactttg     3480

tagtatgata ggttattttg atgtaaagat gttctggata ccattatatg ttccccctgt     3540

ttcagaggct cagattgtaa tatgtaaatg gtatgtcatt cgctactatg atttaatttg     3600

aaatatggtc ttttggttat gaatactttg cagcacagct gagaggctgt ctgttgtatt     3660

cattgtggtc atagcaccta acaacattgt agcctcaatc gagtgagaca gactagaagt     3720

tcctagtgat ggcttatgat agcaaatggc ctcatgtcaa atatttagat gtaattttgt     3780

gtaagaaata cagactggat gtaccaccaa ctactacctg taatgacagg cctgtccaac     3840

acatctccct tttccatgac tgtggtagcc agcatcggaa agaacgctga tttaaagagg     3900

tcgcttggga attttattga cacagtacca tttaatgggg aggacaaaat ggggcagggg     3960

agggagaagt ttctgtcgtt aaaaacagat ttggaaagac tggactctaa agtctgttga     4020

ttaaagatga gctttgtcta cttcaaaagt ttgtttgctt accccttcag cctccaattt     4080

tttaagtgaa aatatagcta ataacatgtg aaaagaatag aagctaaggt ttagataaat     4140

attgagcaga tctataggaa gattgaacct gaatattgcc attatgcttg acatggtttc     4200

caaaaaatgg tactccacat atttcagtga gggtaagtat tttcctgttg tcaagaatag     4260

cattgtaaaa gcattttgta ataataaaga atagctttaa tgatatgctt gtaactaaaa     4320

taattttgta atgtatcaaa tacatttaaa acattaaaat ataatctcta taataagagc     4380

tcgctgatca gcctcgactg tgccttctag ttgccagcca tctgttgttt gcccctcccc     4440

cgtgccttcc ttgaccctgg aaggtgccac tcccactgtc ctttcctaat aaaatgagga     4500

aattgcatcg cattgtctga gtaggtgtca ttctattctg gggggtgggg tggggcagga     4560

cagcaagggg gaggattggg aagacaatag caggcatgct ggggatgcgg tgggctctat     4620

ggaagcttga attcagctga cgtgcctcgg accgctagga acccctagtg atggagttgg     4680

ccactccctc tctgcgcgct cgctcgctca ctgaggccgg gcgaccaaag gtcgcccgac     4740

gcccgggctt tgcccgggcg gcctcagtga gcgagcgagc gcgcag                    4786


<210>  83
<211>  4018
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary construct sequence

<400>  83
ctgcgcgctc gctcgctcac tgaggccgcc cgggcgtcgg gcgacctttg gtcgcccggc       60

ctcagtgagc gagcgagcgc gcagagaggg agtggccaac tccatcacta ggggttcctg      120

cggccgcacg cgtgacattg attattgact agttattaat agtaatcaat tacggggtca      180

ttagttcata gcccatatat ggagttccgc gttacataac ttacggtaaa tggcccgcct      240

ggctgaccgc ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt tcccatagta      300

acgccaatag ggactttcca ttgacgtcaa tgggtggact atttacggta aactgcccac      360

ttggcagtac atcaagtgta tcatatgcca agtacgcccc ctattgacgt caatgacggt      420

aaatggcccg cctggcatta tgcccagtac atgaccttat gggactttcc tacttggcag      480

tacatctacg tattagtcat cgctattacc atgggtcgag gtgagcccca cgttctgctt      540

cactctcccc atctcccccc cctccccacc cccaattttg tatttattta ttttttaatt      600

attttgtgca gcgatggggg cggggggggg gggggcgcgc gccaggcggg gcggggcggg      660

gcgaggggcg gggcggggcg aggcggagag gtgcggcggc agccaatcag agcggcgcgc      720

tccgaaagtt tccttttatg gcgaggcggc ggcggcggcg gccctataaa aagcgaagcg      780

cgcggcgggc gggagtcgct gcgttgcctt cgccccgtgc cccgctccgc gccgcctcgc      840

gccgcccgcc ccggctctga ctgaccgcgt tactcccaca ggtgagcggg cgggacggcc      900

cttctcctcc gggctgtaat tagcgcttgg tttaatgacg gcttgtttct tttctgtggc      960

tgcgtgaaag ccttgagggg ctccgggagc tagagcctct gctaaccatg ttcatgcctt     1020

cttctttttc ctacagctcc tgggcaacgt gctggttatt gtgaccggtg ttgcggcccc     1080

gcagcgcccg cgcgctcctc tccccgactc ggagcccctc ggcggcgccc ggcccaggac     1140

ccgcctagga gcgcaggagc cccagcgcag agaccccaac gccgagaccc ccgccccggc     1200

cccgccgcgc ttcctcccga cgcagtttag gacccttgtt cgcgaagagg tggtgtgcgg     1260

ctgagacccg cgtcctcagg acggttccat cagtgcctcg atcctgcccc actggaggag     1320

gaaggcagcc cgaacagcgc tcacctaact aacagctgct gagagctggg ttccgtggcc     1380

atgcacctgg gactgccttg agaagcgtga gcaaaccgcc cagagtagaa gcgctagcca     1440

ccatggattg gggcacgctg cagacgatcc tggggggtgt gaacaaacac tccaccagca     1500

ttggaaagat ctggctcacc gtcctcttca tttttcgcat tatgatcctc gttgtggctg     1560

caaaggaggt gtggggagat gagcaggccg actttgtctg caacaccctg cagccaggct     1620

gcaagaacgt gtgctacgat cactacttcc ccatctccca catccggcta tgggccctgc     1680

agctgatctt cgtgtccacg ccagcgctcc tagtggccat gcacgtggcc taccggagac     1740

atgagaagaa gaggaagttc atcaaggggg agataaagag tgaatttaag gacatcgagg     1800

agatcaaaac ccagaaggtc cgcatcgaag gctccctgtg gtggacctac acaagcagca     1860

tcttcttccg ggtcatcttc gaagccgcct tcatgtacgt cttctatgtc atgtacgacg     1920

gcttctccat gcagcggctg gtgaagtgca acgcctggcc ttgtcccaac actgtggact     1980

gctttgtgtc ccggcccacg gagaagactg tcttcacagt gttcatgatt gcagtgtctg     2040

gaatttgcat cctgctgaat gtcactgaat tgtgttattt gctaattaga tattgttctg     2100

ggaagtcaaa aaagccagtt ggatcccggg ctgactacaa agaccatgac ggtgattata     2160

aagatcatga catcgactac aaggatgacg atgacaagta agaaatagac agcatgagag     2220

ggatgaggca acccgtgctc agctgtcaag gctcagtcgc tagcatttcc caacacaaag     2280

attctgacct taaatgcaac catttgaaac ccctgtaggc ctcaggtgaa actccagatg     2340

ccacaatgga gctctgctcc cctaaagcct caaaacaaag gcctaattct atgcctgtct     2400

taattttctt tcacttaagt tagttccact gagaccccag gctgttaggg gttattggtg     2460

taaggtactt tcatatttta aacagaggat atcggcattt gtttctttct ctgaggacaa     2520

gagaaaaaag ccaggttcca cagaggacac agagaaggtt tgggtgtcct cctggggttc     2580

tttttgccaa ctttccccac gttaaaggtg aacattggtt ctttcatttg ctttggaagt     2640

tttaatctct aacagtggac aaagttacca gtgccttaaa ctctgttaca ctttttggaa     2700

gtgaaaactt tgtagtatga taggttattt tgatgtaaag atgttctgga taccattata     2760

tgttccccct gtttcagagg ctcagattgt aatatgtaaa tggtatgtca ttcgctacta     2820

tgatttaatt tgaaatatgg tcttttggtt atgaatactt tgcagcacag ctgagaggct     2880

gtctgttgta ttcattgtgg tcatagcacc taacaacatt gtagcctcaa tcgagtgaga     2940

cagactagaa gttcctagtg atggcttatg atagcaaatg gcctcatgtc aaatatttag     3000

atgtaatttt gtgtaagaaa tacagactgg atgtaccacc aactactacc tgtaatgaca     3060

ggcctgtcca acacatctcc cttttccatg actgtggtag ccagcatcgg aaagaacgct     3120

gatttaaaga ggtcgcttgg gaattttatt gacacagtac catttaatgg ggaggacaaa     3180

atggggcagg ggagggagaa gtttctgtcg ttaaaaacag atttggaaag actggactct     3240

aaagtctgtt gattaaagat gagctttgtc tacttcaaaa gtttgtttgc ttaccccttc     3300

agcctccaat tttttaagtg aaaatatagc taataacatg tgaaaagaat agaagctaag     3360

gtttagataa atattgagca gatctatagg aagattgaac ctgaatattg ccattatgct     3420

tgacatggtt tccaaaaaat ggtactccac atatttcagt gagggtaagt attttcctgt     3480

tgtcaagaat agcattgtaa aagcattttg taataataaa gaatagcttt aatgatatgc     3540

ttgtaactaa aataattttg taatgtatca aatacattta aaacattaaa atataatctc     3600

tataataaga gctcgctgat cagcctcgac tgtgccttct agttgccagc catctgttgt     3660

ttgcccctcc cccgtgcctt ccttgaccct ggaaggtgcc actcccactg tcctttccta     3720

ataaaatgag gaaattgcat cgcattgtct gagtaggtgt cattctattc tggggggtgg     3780

ggtggggcag gacagcaagg gggaggattg ggaagacaat agcaggcatg ctggggatgc     3840

ggtgggctct atggaagctt gaattcagct gacgtgcctc ggaccgctag gaacccctag     3900

tgatggagtt ggccactccc tctctgcgcg ctcgctcgct cactgaggcc gggcgaccaa     3960

aggtcgcccg acgcccgggc tttgcccggg cggcctcagt gagcgagcga gcgcgcag       4018


<210>  84
<211>  4508
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary construct sequence

<400>  84
ctgcgcgctc gctcgctcac tgaggccgcc cgggcgtcgg gcgacctttg gtcgcccggc       60

ctcagtgagc gagcgagcgc gcagagaggg agtggccaac tccatcacta ggggttcctg      120

cggccgcacg cgtgacattg attattgact agttattaat agtaatcaat tacggggtca      180

ttagttcata gcccatatat ggagttccgc gttacataac ttacggtaaa tggcccgcct      240

ggctgaccgc ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt tcccatagta      300

acgccaatag ggactttcca ttgacgtcaa tgggtggact atttacggta aactgcccac      360

ttggcagtac atcaagtgta tcatatgcca agtacgcccc ctattgacgt caatgacggt      420

aaatggcccg cctggcatta tgcccagtac atgaccttat gggactttcc tacttggcag      480

tacatctacg tattagtcat cgctattacc atgggtaagc ttccgcagaa tcctatcagt      540

ttcccccttt cgtgctgtgt gcatcgagca ggaaggggct tggcaggttt tacctgccct      600

ctttcctttc tgaaaagtct gggcctcctc accccgaaag gagtcacctc cttgcagttc      660

cccagttgcg aaaagaggag gaagttggct gggccggggg ccgcgggggg caccctccgc      720

agatggcggg acccccctgc cggccatggc aaaaacgagg cttgtctctc ccaccgcccc      780

caaccttagt ccttggcaca ttgttgaaag taattgaata aaatcggaaa ttcgagaagg      840

cgttcgttcg gattggtgag attttgaggg gagaaagaag cggggacttc gccggcacca      900

gcggcgcccc ctcctcggcc accgttaacc cccattccag agggcactgc cccgccaccc      960

agcctaggtc cccctgcgag agcctcgcgg gcccgcgcag cctccgcgac tcgaacagat     1020

cttcagtcct tggaggaatg cctgtttctc taacaataaa aaattaaaga agcgctcata     1080

aatgccaagt cctctcgcac tatgcggagt acagaggaca acgaccacag ccatccctga     1140

accccgccca cggcacagcg ccggagccgg ggtctggggc gccgcttcct ggggggtccc     1200

gactctcagc cgcccccgct tcacccgggc cgccaagggg ctgggggagg cggcgctcgg     1260

ggtaaccggg ggagactcag ggcgctgggg gcacttgggg aactcatggg ggctcaaagg     1320

aactaggaga tcgggacctc gaaggggact tggggggttc ggggctttcg ggggcggtcg     1380

ggggttcgcg gacccgggaa gctctgagga cccagaggcc gggcgcgctc cgcccgcggc     1440

gccgccccct ccgtaacttt cccagtctcc gagggaagag gcggggtgtg gggtgcggtt     1500

aaaaggcgcc acggcgggag acaggtctcc tgggcaacgt gctggttatt gtgaccggtg     1560

ttgcggcccc gcagcgcccg cgcgctcctc tccccgactc ggagcccctc ggcggcgccc     1620

ggcccaggac ccgcctagga gcgcaggagc cccagcgcag agaccccaac gccgagaccc     1680

ccgccccggc cccgccgcgc ttcctcccga cgcagtttag gacccttgtt cgcgaagagg     1740

tggtgtgcgg ctgagacccg cgtcctcagg acggttccat cagtgcctcg atcctgcccc     1800

actggaggag gaaggcagcc cgaacagcgc tcacctaact aacagctgct gagagctggg     1860

ttccgtggcc atgcacctgg gactgccttg agaagcgtga gcaaaccgcc cagagtagaa     1920

gcgctagcca ccatggattg gggcacgctg cagacgatcc tggggggtgt gaacaaacac     1980

tccaccagca ttggaaagat ctggctcacc gtcctcttca tttttcgcat tatgatcctc     2040

gttgtggctg caaaggaggt gtggggagat gagcaggccg actttgtctg caacaccctg     2100

cagccaggct gcaagaacgt gtgctacgat cactacttcc ccatctccca catccggcta     2160

tgggccctgc agctgatctt cgtgtccacg ccagcgctcc tagtggccat gcacgtggcc     2220

taccggagac atgagaagaa gaggaagttc atcaaggggg agataaagag tgaatttaag     2280

gacatcgagg agatcaaaac ccagaaggtc cgcatcgaag gctccctgtg gtggacctac     2340

acaagcagca tcttcttccg ggtcatcttc gaagccgcct tcatgtacgt cttctatgtc     2400

atgtacgacg gcttctccat gcagcggctg gtgaagtgca acgcctggcc ttgtcccaac     2460

actgtggact gctttgtgtc ccggcccacg gagaagactg tcttcacagt gttcatgatt     2520

gcagtgtctg gaatttgcat cctgctgaat gtcactgaat tgtgttattt gctaattaga     2580

tattgttctg ggaagtcaaa aaagccagtt ggatcccggg ctgactacaa agaccatgac     2640

ggtgattata aagatcatga catcgactac aaggatgacg atgacaagta agaaatagac     2700

agcatgagag ggatgaggca acccgtgctc agctgtcaag gctcagtcgc tagcatttcc     2760

caacacaaag attctgacct taaatgcaac catttgaaac ccctgtaggc ctcaggtgaa     2820

actccagatg ccacaatgga gctctgctcc cctaaagcct caaaacaaag gcctaattct     2880

atgcctgtct taattttctt tcacttaagt tagttccact gagaccccag gctgttaggg     2940

gttattggtg taaggtactt tcatatttta aacagaggat atcggcattt gtttctttct     3000

ctgaggacaa gagaaaaaag ccaggttcca cagaggacac agagaaggtt tgggtgtcct     3060

cctggggttc tttttgccaa ctttccccac gttaaaggtg aacattggtt ctttcatttg     3120

ctttggaagt tttaatctct aacagtggac aaagttacca gtgccttaaa ctctgttaca     3180

ctttttggaa gtgaaaactt tgtagtatga taggttattt tgatgtaaag atgttctgga     3240

taccattata tgttccccct gtttcagagg ctcagattgt aatatgtaaa tggtatgtca     3300

ttcgctacta tgatttaatt tgaaatatgg tcttttggtt atgaatactt tgcagcacag     3360

ctgagaggct gtctgttgta ttcattgtgg tcatagcacc taacaacatt gtagcctcaa     3420

tcgagtgaga cagactagaa gttcctagtg atggcttatg atagcaaatg gcctcatgtc     3480

aaatatttag atgtaatttt gtgtaagaaa tacagactgg atgtaccacc aactactacc     3540

tgtaatgaca ggcctgtcca acacatctcc cttttccatg actgtggtag ccagcatcgg     3600

aaagaacgct gatttaaaga ggtcgcttgg gaattttatt gacacagtac catttaatgg     3660

ggaggacaaa atggggcagg ggagggagaa gtttctgtcg ttaaaaacag atttggaaag     3720

actggactct aaagtctgtt gattaaagat gagctttgtc tacttcaaaa gtttgtttgc     3780

ttaccccttc agcctccaat tttttaagtg aaaatatagc taataacatg tgaaaagaat     3840

agaagctaag gtttagataa atattgagca gatctatagg aagattgaac ctgaatattg     3900

ccattatgct tgacatggtt tccaaaaaat ggtactccac atatttcagt gagggtaagt     3960

attttcctgt tgtcaagaat agcattgtaa aagcattttg taataataaa gaatagcttt     4020

aatgatatgc ttgtaactaa aataattttg taatgtatca aatacattta aaacattaaa     4080

atataatctc tataataaga gctcgctgat cagcctcgac tgtgccttct agttgccagc     4140

catctgttgt ttgcccctcc cccgtgcctt ccttgaccct ggaaggtgcc actcccactg     4200

tcctttccta ataaaatgag gaaattgcat cgcattgtct gagtaggtgt cattctattc     4260

tggggggtgg ggtggggcag gacagcaagg gggaggattg ggaagacaat agcaggcatg     4320

ctggggatgc ggtgggctct atggaagctt gaattcagct gacgtgcctc ggaccgctag     4380

gaacccctag tgatggagtt ggccactccc tctctgcgcg ctcgctcgct cactgaggcc     4440

gggcgaccaa aggtcgcccg acgcccgggc tttgcccggg cggcctcagt gagcgagcga     4500

gcgcgcag                                                              4508


<210>  85
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary cloning site Q

<400>  85
ctcaccggt                                                                9


<210>  86
<211>  128
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary hGJB2 basal promoter

<400>  86
aagctctgag gacccagagg ccgggcgcgc tccgcccgcg gcgccgcccc ctccgtaact       60

ttcccagtct ccgagggaag aggcggggtg tggggtgcgg ttaaaaggcg ccacggcggg      120

agacaggt                                                               128


<210>  87
<211>  4745
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary construct sequence

<400>  87
ctgcgcgctc gctcgctcac tgaggccgcc cgggcgtcgg gcgacctttg gtcgcccggc       60

ctcagtgagc gagcgagcgc gcagagaggg agtggccaac tccatcacta ggggttcctg      120

cggccgcacg cgtgacattg attattgact agttattaat agtaatcaat tacggggtca      180

ttagttcata gcccatatat ggagttccgc gttacataac ttacggtaaa tggcccgcct      240

ggctgaccgc ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt tcccatagta      300

acgccaatag ggactttcca ttgacgtcaa tgggtggact atttacggta aactgcccac      360

ttggcagtac atcaagtgta tcatatgcca agtacgcccc ctattgacgt caatgacggt      420

aaatggcccg cctggcatta tgcccagtac atgaccttat gggactttcc tacttggcag      480

tacatctacg tattagtcat cgctattacc atgggtcgag gtgagcccca cgttctgctt      540

cactctcccc atctcccccc cctccccacc cccaattttg tatttattta ttttttaatt      600

attttgtgca gcgatggggg cggggggggg gggggcgcgc gccaggcggg gcggggcggg      660

gcgaggggcg gggcggggcg aggcggagag gtgcggcggc agccaatcag agcggcgcgc      720

tccgaaagtt tccttttatg gcgaggcggc ggcggcggcg gccctataaa aagcgaagcg      780

cgcggcgggc gggagtcgct gcgttgcctt cgccccgtgc cccgctccgc gccgcctcgc      840

gccgcccgcc ccggctctga ctgaccgcgt tactcccaca ggtgagcggg cgggacggcc      900

cttctcctcc gggctgtaat tagcgcttgg tttaatgacg gctcgtttct tttctgtggc      960

tgcgtgaaag ccttaaaggg ctccgggagg gccctttgtg cgggggggag cggctcgggg     1020

ggtgcgtgcg tgtgtgtgtg cgtggggagc gccgcgtgcg gcccgcgctg cccggcggct     1080

gtgagcgctg cgggcgcggc gcggggcttt gtgcgctccg cgtgtgcgcg aggggagcgc     1140

ggccgggggc ggtgccccgc ggtgcggggg ggctgcgagg ggaacaaagg ctgcgtgcgg     1200

ggtgtgtgcg tgggggggtg agcagggggt gtgggcgcgg cggtcgggct gtaacccccc     1260

cctgcacccc cctccccgag ttgctgagca cggcccggct tcgggtgcgg ggctccgtgc     1320

ggggcgtggc gcggggctcg ccgtgccggg cggggggtgg cggcaggtgg gggtgccggg     1380

cggggcgggg ccgcctcggg ccggggaggg ctcgggggag gggcgcggcg gcccccggag     1440

cgccggcggc tgtcgaggcg cggcgagccg cagccattgc cttttatggt aatcgtgcga     1500

gagggcgcag ggacttcctt tgtcccaaat ctgtgcggag ccgaaatctg ggaggcgccg     1560

ccgcaccccc tctagcgggc gcggggcgaa gcggtgcggc gccggcagga aggaaatggg     1620

cggggagggc cttcgtgcgt cgccgcgccg ccgtcccctt ctccctctcc agcctcgggg     1680

ctgtccgcgg ggggacggct gccttcgggg gggacggggc agggcggggt tcggcttctg     1740

gcgtgtgacc ggcggctcta gagcctctgc taaccatgtt catgccttct tctttttcct     1800

acagctcctg ggcaacgtgc tggttattgt gaccggtgtt gcggccccgc agcgcccgcg     1860

cgctcctctc cccgactcgg agcccctcgg cggcgcccgg cccaggaccc gcctaggagc     1920

gcaggagccc cagcgcagag accccaacgc cgagaccccc gccccggccc cgccgcgctt     1980

cctcccgacg cagtttagga cccttgttcg cgaagaggtg gtgtgcggct gagacccgcg     2040

tcctcaggac ggttccatca gtgcctcgat cctgccccac tggaggagga aggcagcccg     2100

aacagcgctc acctaactaa cagctgctga gagctgggtt ccgtggccat gcacctggga     2160

ctgccttgag aagcgtgagc aaaccgccca gagtagaagc gctagccacc atggattggg     2220

gcacgctgca gacgatcctg gggggtgtga acaaacactc caccagcatt ggaaagatct     2280

ggctcaccgt cctcttcatt tttcgcatta tgatcctcgt tgtggctgca aaggaggtgt     2340

ggggagatga gcaggccgac tttgtctgca acaccctgca gccaggctgc aagaacgtgt     2400

gctacgatca ctacttcccc atctcccaca tccggctatg ggccctgcag ctgatcttcg     2460

tgtccacgcc agcgctccta gtggccatgc acgtggccta ccggagacat gagaagaaga     2520

ggaagttcat caagggggag ataaagagtg aatttaagga catcgaggag atcaaaaccc     2580

agaaggtccg catcgaaggc tccctgtggt ggacctacac aagcagcatc ttcttccggg     2640

tcatcttcga agccgccttc atgtacgtct tctatgtcat gtacgacggc ttctccatgc     2700

agcggctggt gaagtgcaac gcctggcctt gtcccaacac tgtggactgc tttgtgtccc     2760

ggcccacgga gaagactgtc ttcacagtgt tcatgattgc agtgtctgga atttgcatcc     2820

tgctgaatgt cactgaattg tgttatttgc taattagata ttgttctggg aagtcaaaaa     2880

agccagttgg atcccgggct gactacaaag accatgacgg tgattataaa gatcatgaca     2940

tcgactacaa ggatgacgat gacaagtaag agctcagtgt gagttctacc attgccaaac     3000

tcgagcagtg aattctacca gtgccatagg atccagtgtg agttctacca ttgccaaagg     3060

tacccagtga attctaccag tgccatagtt aaccgcattg cccagttgtt agattaagaa     3120

atagacagca tgagagggat gaggcaaccc gtgctcagct gtcaaggctc agtcgctagc     3180

atttcccaac acaaagattc tgaccttaaa tgcaaccatt tgaaacccct gtaggcctca     3240

ggtgaaactc cagatgccac aatggagcct ctgctcccct aaagcctcaa aacaaaggcc     3300

taattctatg cctgtcttaa ttttctttca cttaagttag ttccactgag accccaggct     3360

gttaggggtt attggtgtaa ggtactttca tattttaaac agaggatatc ggcatttgtt     3420

tctttctctg aggacaagag aaaaaagcca ggttccacag aggacacaga gaaggtttgg     3480

gtgtcctcct ggggttcttt ttgccaactt tccccacgtt aaaggtgaac attggttctt     3540

tcatttgctt tggaagtttt aatctctaac agtggacaaa gttaccagtg ccttaaactc     3600

tgttacactt tttggaagtg aaaactttgt agtatgatag gttattttga tgtaaagatg     3660

ttctggatac cattatatgt tccccctgtt tcagaggctc agattgtaat atgtaaatgg     3720

tatgtcattc gctactatga tttaatttga aatatggtct tttggttatg aatactttgc     3780

agcacagctg agaggctgtc tgttgtattc attgtggtca tagcacctaa caacattgta     3840

gcctcaatcg agtgagacag actagaagtt cctagtgatg gcttatgata gcaaatggcc     3900

tcatgtcaaa tatttagatg taattttgtg taagaaatac agactggatg taccaccaac     3960

tactacctgt aatgacaggc ctgtccaaca catctccctt ttccatgact gtggtagcca     4020

gcatcggaaa gaacgctgat ttaaagaggt cgcttgggaa ttttattgac acagtaccat     4080

ttaatgggga ggacaaaatg gggcagggga gggagaagtt tctgtcgtta aaaacagatt     4140

tggaaagact ggactctaaa gtctgttgat taaagatgag ctttgtctac ttcaaaagtt     4200

tgtttgctta ccccttcagc ctccaatttt ttaagtgaaa atatagctaa taacatgtga     4260

aaagaataga agctaaggtt tagataaata ttgagcagat ctataggaag attgaacctg     4320

aatattgcca ttatgcttga cgctgatcag cctcgactgt gccttctagt tgccagccat     4380

ctgttgtttg cccctccccc gtgccttcct tgaccctgga aggtgccact cccactgtcc     4440

tttcctaata aaatgaggaa attgcatcgc attgtctgag taggtgtcat tctattctgg     4500

ggggtggggt ggggcaggac agcaaggggg aggattggga agacaatagc aggcatgctg     4560

gggatgcggt gggctctatg gaagcttgaa ttcagctgac gtgcctcgga ccgctaggaa     4620

cccctagtga tggagttggc cactccctct ctgcgcgctc gctcgctcac tgaggccggg     4680

cgaccaaagg tcgcccgacg cccgggcttt gcccgggcgg cctcagtgag cgagcgagcg     4740

cgcag                                                                 4745


<210>  88
<211>  4712
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary construct sequence

<400>  88
ctgcgcgctc gctcgctcac tgaggccgcc cgggcgtcgg gcgacctttg gtcgcccggc       60

ctcagtgagc gagcgagcgc gcagagaggg agtggccaac tccatcacta ggggttcctg      120

cggccgcacg cgtcttcttc tggagtcttt tctggaataa ttctgggagt gggctcagcc      180

tgcgggagag taacattttt ataacttgat agatgtagct gagatgcctc ccagagggga      240

gacccgcctc tcctccggca gctgtgcacg taggcttgtt cccagcagcc tggccagggt      300

ggtccacctg gtgtttctca tcttctttcc ccggagcgct gactcctgcg cgtcctcttg      360

gaagactctt gacaggacgg gtgttttatg ggtgtgattc agtgtcctct tgcatcagtt      420

caatgtggtg gtgttcaatc aacccttgta gcgttagcaa aatttgctca agtcattccg      480

caggaatgtc tgtgtcttgc ttccaagaaa gcttgtaagt gccggcaaca ggccaagcag      540

ctcacaaacc tgaccacaag cctgtgagta attgtggggc agcacttagc agtcttttat      600

tttcgactta ttaaagtctc atcttggcct caccttctcc ctggaaggtg gcgtgggtgg      660

gaaccactgg gtcagatctt tttcaccctt gccgtggagc cagtttcctg ttgcatgtgg      720

gggaagcaac atgtggtgaa gagtatagaa aacgaaaaca tgtgggtaca gtatgtataa      780

gtggagggaa caaactcata attccaacta gtttctcatg agagactcat gaatcattgt      840

ggtagttctc aatataaact taatctaggc cggatgtggt ggctcacacc tgtaatctca      900

gcactctggg tggatcactt gaggtcagga gtttgagacc agtctgacca acatggagaa      960

accccatcgc tactaaaaat acaaaattat ccagatgtgg tggctcacac ctgtaatccc     1020

agcactttgg gaggctgagg cgggtggatc acttgaggtc aggagtttga gaccagcctg     1080

accaacatgg agaaactgtg tctctactaa aaatacaaaa ttagctgggc gtggtgacgc     1140

atgcctgtaa tcccagctat ttggaggccg aagcaggaag cttccgcaga atcctatcag     1200

tttccccctt tcgtgctgtg tgcatcgagc aggaaggggc ttggcaggtt ttacctgccc     1260

tctttccttt ctgaaaagtc tgggcctcct caccccgaaa ggagtcacct ccttgcagtt     1320

ccccagttgc gaaaagagga ggaagttggc tgggccgggg gccgcggggg gcaccctccg     1380

cagatggcgg gacccccctg ccggccatgg caaaaacgag gcttgtctct cccaccgccc     1440

ccaaccttag tccttggcac attgttgaaa gtaattgaat aaaatcggaa attcgagaag     1500

gcgttcgttc ggattggtga gattttgagg ggagaaagaa gcggggactt cgccggcacc     1560

agcggcgccc cctcctcggc caccgttaac ccccattcca gagggcactg ccccgccacc     1620

cagcctaggt ccccctgcga gagcctcgcg ggcccgcgca gcctccgcga ctcgaacaga     1680

tcttcagtcc ttggaggaat gcctgtttct ctaacaataa aaaattaaag aagcgctcat     1740

aaatgccaag tcctctcgca ctatgcggag tacagaggac aacgaccaca gccatccctg     1800

aaccccgccc acggcacagc gccggagccg gggtctgggg cgccgcttcc tggggggtcc     1860

cgactctcag ccgcccccgc ttcacccggg ccgccaaggg gctgggggag gcggcgctcg     1920

gggtaaccgg gggagactca gggcgctggg ggcacttggg gaactcatgg gggctcaaag     1980

gaactaggag atcgggacct cgaaggggac ttggggggtt cggggctttc gggggcggtc     2040

gggggttcgc ggacccggga agctctgagg acccagaggc cgggcgcgct ccgcccgcgg     2100

cgccgccccc tccgtaactt tcccagtctc cgagggaaga ggcggggtgt ggggtgcggt     2160

taaaaggcgc cacggcggga gacaggtgtt gcggccccgc agcgcccgcg cgctcctctc     2220

cccgactcgg agcccctcgg cggcgcccgg cccaggaccc gcctaggagc gcaggagccc     2280

cagcgcagag accccaacgc cgagaccccc gccccggccc cgccgcgctt cctcccgacg     2340

cagagcaaac cgcccagagt agaagaccgg tcgctagcca ccatggattg gggcacgctg     2400

cagacgatcc tggggggtgt gaacaaacac tccaccagca ttggaaagat ctggctcacc     2460

gtcctcttca tttttcgcat tatgatcctc gttgtggctg caaaggaggt gtggggagat     2520

gagcaggccg actttgtctg caacaccctg cagccaggct gcaagaacgt gtgctacgat     2580

cactacttcc ccatctccca catccggcta tgggccctgc agctgatctt cgtgtccacg     2640

ccagcgctcc tagtggccat gcacgtggcc taccggagac atgagaagaa gaggaagttc     2700

atcaaggggg agataaagag tgaatttaag gacatcgagg agatcaaaac ccagaaggtc     2760

cgcatcgaag gctccctgtg gtggacctac acaagcagca tcttcttccg ggtcatcttc     2820

gaagccgcct tcatgtacgt cttctatgtc atgtacgacg gcttctccat gcagcggctg     2880

gtgaagtgca acgcctggcc ttgtcccaac actgtggact gctttgtgtc ccggcccacg     2940

gagaagactg tcttcacagt gttcatgatt gcagtgtctg gaatttgcat cctgctgaat     3000

gtcactgaat tgtgttattt gctaattaga tattgttctg ggaagtcaaa aaagccagtt     3060

ggatcccggg ctgactacaa agaccatgac ggtgattata aagatcatga catcgactac     3120

aaggatgacg atgacaagta agaaatagac agcatgagag ggatgaggca acccgtgctc     3180

agctgtcaag gctcagtcgc tagcatttcc caacacaaag attctgacct taaatgcaac     3240

catttgaaac ccctgtaggc ctcaggtgaa actccagatg ccacaatgga gctctgctcc     3300

cctaaagcct caaaacaaag gcctaattct atgcctgtct taattttctt tcacttaagt     3360

tagttccact gagaccccag gctgttaggg gttattggtg taaggtactt tcatatttta     3420

aacagaggat atcggcattt gtttctttct ctgaggacaa gagaaaaaag ccaggttcca     3480

cagaggacac agagaaggtt tgggtgtcct cctggggttc tttttgccaa ctttccccac     3540

gttaaaggtg aacattggtt ctttcatttg ctttggaagt tttaatctct aacagtggac     3600

aaagttacca gtgccttaaa ctctgttaca ctttttggaa gtgaaaactt tgtagtatga     3660

taggttattt tgatgtaaag atgttctgga taccattata tgttccccct gtttcagagg     3720

ctcagattgt aatatgtaaa tggtatgtca ttcgctacta tgatttaatt tgaaatatgg     3780

tcttttggtt atgaatactt tgcagcacag ctgagaggct gtctgttgta ttcattgtgg     3840

tcatagcacc taacaacatt gtagcctcaa tcgagtgaga cagactagaa gttcctagtg     3900

atggcttatg atagcaaatg gcctcatgtc aaatatttag atgtaatttt gtgtaagaaa     3960

tacagactgg atgtaccacc aactactacc tgtaatgaca ggcctgtcca acacatctcc     4020

cttttccatg actgtggtag ccagcatcgg aaagaacgct gatttaaaga ggtcgcttgg     4080

gaattttatt gacacagtac catttaatgg ggaggacaaa atggggcagg ggagggagaa     4140

gtttctgtcg ttaaaaacag atttggaaag actggactct aaagtctgtt gattaaagat     4200

gagctttgtc tacttcaaaa gtttgtttgc ttaccccttc agcctccaat tttttaagtg     4260

aaaatatagc taataacatg tgaaaagaat agaagctaag gtttagataa atattgagca     4320

gatctatagg aagattgaac ctgaatattg ccattatgct tgacatggtt tccaaaaaat     4380

ggtactccac atatttcagt gagggtaagt attttcctgt tgtcaagaat agcattgtaa     4440

aagcattttg taataataaa gaatagcttt aatgatatgc ttgtaactaa aataattttg     4500

taatgtatca aatacattta aaacattaaa atataatctc tataataaaa gcttgaattc     4560

agctgacgtg cctcggaccg ctaggaaccc ctagtgatgg agttggccac tccctctctg     4620

cgcgctcgct cgctcactga ggccgggcga ccaaaggtcg cccgacgccc gggctttgcc     4680

cgggcggcct cagtgagcga gcgagcgcgc ag                                   4712


<210>  89
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary sNRP poly(A) signal sequence

<400>  89
aaataaaata cgaaatg                                                      17


<210>  90
<211>  1188
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary GDF6 promoter

<400>  90
ccacaggtaa ctccgtcggc gtccacaggg gggcaggaga taccatactg cacagttgta       60

cgtcttccat ctgtttggtg tagaaaaatc taaccactac aagaatgcca cgggcactgt      120

ggcagacaga agcagcgcta cgccgcatcg cctttcagcg tgcaggccca ggaatgagcg      180

aggcagtggg cggggaagac aggcacgggg aatctgggga cagataaagg aaactcgtga      240

tggggcgagg ctgggctgaa gagaaacaga ttggggtaga gctgcaaagg gaggggtcca      300

ctggaaggcg aggggggagg ccgggaagag agagggtggg aaggcagtgt gagatgggag      360

ggcagtgtga gaagaaaagc aggctgggga agagggattg gaatgcagaa ggaacttggg      420

gaaggaggaa gtcctgcagg cgggagggaa agaagagagg gggagcagct aaagtctgcg      480

tcagaagagg ttggggactg cgagaggaga ggctggggcc tgcaggggag cgcagcagct      540

tttagcatcg atccaaactc taaagactcg tggcctttgc ctgacctcga gggtcgggaa      600

tagacgcctg tctttgtgga gagcgatacc caaccgagaa aatggggctg ttccgagctg      660

ggccctgcgc ctggcccagg gcgaggcttc tctggctccg ggctggcccc tgaggggcag      720

cacgcagcct gcagcagagg cgcctgctcc aagctgtctc ttgggggcgc cgccgccgct      780

tccctcctcc ggggccgctc gctcccagga aagtggaggc ggctggcgag gaccgagagc      840

cggggccgcg ctgcggaggg accacacctc cgggagttcg agggggaccc tggcgcggcg      900

ggccagcctt tcgggccggc agcgcccgcc ttcccccggt cagcgcttgc ggcccgcgcc      960

gcgcgcaccg cccggcaacc ccgcgcgcgt cccgcggggg cgctgcgtct tcctgccaca     1020

ccggcgcacc gcggcccctc tcccccacac ctccggcccg caccacccgg ctctcctccc     1080

accctcccca cccctcctct gccctccctc cccattcctc ccctcccggc gaggggcggg     1140

agggggcgtg gcggggccgg ggtttgtgtg gctgggaccc ggctcctc                  1188


<210>  91
<211>  680
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GFAP promoter

<400>  91
gaacatatcc tggtgtggag taggggacgc tgctctgaca gaggctcggg ggcctgagct       60

ggctctgtga gctggggagg aggcagacag ccaggccttg tctgcaagca gacctggcag      120

cattgggctg gccgcccccc agggcctcct cttcatgccc agtgaatgac tcaccttggc      180

acagacacaa tgttcggggt gggcacagtg cctgcttccc gccgcacccc agcccccctc      240

aaatgccttc cgagaagccc attgagcagg gggcttgcat tgcaccccag cctgacagcc      300

tggcatcttg ggataaaagc agcacagccc cctaggggct gcccttgctg tgtggcgcca      360

ccggcggtgg agaacaaggc tctattcagc ctgtgcccag gaaaggggat caggggatgc      420

ccaggcatgg acagtgggtg gcaggggggg agaggagggc tgtctgcttc ccagaagtcc      480

aaggacacaa atgggtgagg ggagctctcc ccatagctgg gctgcggccc aaccccaccc      540

cctcaggcta tgccaggggg tgttgccagg ggcacccggg catcgccagt ctagcccact      600

ccttcataaa gccctcgcat cccaggagcg agcagagcca gagcaggttg gagaggagac      660

gcatcacctc cgctgctcgc                                                  680


<210>  92
<211>  1404
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BACE Promoter

<400>  92
tgtgctgcga gggcttcatc tcctaagcac taaatgctaa attccccctc ccacgcccat       60

cgccactgtc ctcacggatc ctcgcagcag cttcccaatc ggtctccctg tctccagcct      120

caccaccccc aactaagacc attcatgaaa acagagacaa ccaaggagac agtcacccaa      180

tgctgtccct tcagcttgca ttattttctg acaagacagc tctgccatcc atggaagcct      240

gtgtttgaag atctctgaca taaaggtccc ttgcagagct agacgtgatt ctaaaattgg      300

gaacacagga ataaaaatca aatcttgagt agaagtagct gaaaattgca gtgattcggg      360

gaagcttggc ttctaactcc ccactgtttg aagatgggct tgtttgtttt ttaaaacagc      420

caacataatt cagctggagg aggtacaaag aattttctat tccttgtttc tgtagaaatc      480

gatggacttt agcttgtcta attgtccccc ctgcctttag tatctaaaat aaaataaccc      540

tcgttgcttg cattactcaa cgcatttctg cgtcttggcg tctatggcta aacgagtatt      600

aattagacag tccgcagaga gctggctggg gatagaaggg gaggtggggg agaagggcag      660

ggatcacagc agggtggact cgtggccctg atttgggatc ctgacagcaa cttactaggt      720

ggcctgaggg ctgggtgcca ggggaggcag cgggttccag tagcatctga cctgcattag      780

ggacaggggc gcggcggagg gggcgaaggg ggcgggggtg gggggaaggt ggctggggtg      840

aagcccagct tcgcagctag ctgtgggcaa cagagggagt aagggggggc aatgaggctg      900

gggccaggcg ccagcagcag ccacgccccc cacctccccc gatttttagg gaaaattctc      960

caaagctctc gcatcctcct ctgcctcctt ccaccctcca ccctcccagc ctccactgag     1020

acctctttaa aaccacccag gggccgccgg gggatgaggc cggggaacgg gctggactga     1080

gggcgggggc tcgggggcag cggacgggaa acgcctcgaa agcagccaga cccggcgact     1140

gaaatgaggc ggaggagctt ggcgagggga ggcgcaggct cggaaaggcg cgcgaggctc     1200

caggctcctt cccgatccac cgctctcctc gctgacctcc gagtcacccc cggaagctcc     1260

cgccactgcc gggcgaatag acccccgcgg acccccaagc gcgcggggcc ggggccctag     1320

ttcaggccct cgctgcccct ttaagggttc tcgaaacttt ccccccggta tcagatgagc     1380

ctcgtcacat ccgttggccg tggc                                            1404


<210>  93
<211>  1467
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DBI2 promoter

<400>  93
gaagaaacct gcatttctta cacttcagtg tactttcccc atatttaact ccaagatttt       60

tgttaatttg tttggttttc ctttctcaaa caaaattatg ctcagactga aaaccctaga      120

tttgttccct attgcatctt catttcttcc caaacattcc ataaaacgtg acctacatta      180

agttagcaag ttaagtctga aagcgtctac cttccctggg gagggggaag gtgtaggcag      240

ggcagagatt tgtagtccag ccctcttgcc acaaattatg aattagagag gaatgacttt      300

gcttttttaa tgatctccag agaattttcc atcatttccc tctcttcacc cagctccttt      360

gcaaccactg ccagagaagt cttcctttag cttcttaaac atcgatccta aaacacttcc      420

agacacctgt gctgctcctt tcagttccca tggagattag gctgtgtaac aatctcgcaa      480

agacgttccc ctccgtctcc tcatcctctt ttcaaaccct tttacgattt cccatctcac      540

tcagcatgac agtcaaagtc cctgtgatgg ccaacttctg catcacctag ccagtctgcc      600

accgccaaaa ctctccagcc tcatcttaca cttgttctct gcttggaatc ttccctcccc      660

tccttgagga actttctcaa atgtcacctt ccctcaatac tccccctcct ccatttaaaa      720

ctataaactt ccaactctct aagcccctaa agtactctat atttaactta ttgtataaac      780

tactgtccct acttgtaagt tccaagattg cagggattca cccgctttgt tcactgctgt      840

ctgccaaggt ctagaacagt gcaagttacc caacaggagt tcaataaaca gccattcatt      900

taacaaatat ttgctgagca cttcgtcccg tccaagtttg ttaaatcaag acaaataaga      960

caccgtccct gcctttaacg caccagatgg agaaatgcac cacagacata aatgtgcaat     1020

acaggcctga cactacggcc acaagcaagt caaagaacgt gccaaaagtt cagaggaaga     1080

agcctcggct tcgcctttcg ggagaccagt ccagctttcc accatcacgc tgctcatcag     1140

ggaccatctc cgggggtctc ctctagaccc caagggagga gcgggtcccg cccgccattc     1200

ccaggtctca gagtttactt gtccagagat gcaacttccg gcctcttcag gccgggcaag     1260

atttaaggaa agaaaagaaa cataaggacc tccgttcttc ggtctccgtc ccctcccctt     1320

cccccgcgtg ccccacctgt tcccggcgtc cccttcggct actcccggcg tttgcgcaag     1380

cggtcccacg tgggctcggg cggggctagc gccgcggcgg gggctgggca cgcccctagc     1440

gcatagctgg cttctgattg gctttcc                                         1467


<210>  94
<211>  1752
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FABP3 promoter

<400>  94
taccattctg cctttcacct gatgttgcta tcctcctccc tcttgtttcc ttccacccat       60

cctttccctc ccacattact ctcttatccc accctatttt acaaccagta gcctagggaa      120

aagagcatag ctcaaatgag gaagaaggca ggacaggcag tcatggctta gctggactga      180

gctgcagtgc ttctccttct ggggaagggg gtgcactgtc atctgctact gacacatccc      240

tccaaggcac tcagccctgc agggagcaac ctgattctat gactgacatc taatcttcac      300

attcaccttg caggaaggca agaagtgatc ccagcctcca gatggaaaga tcaaggccca      360

gagaaggtca gtggtggttg gaggcctgag gtcacacagc agccaagtct ggagtcacta      420

gtcaaggtga ccttgactag ccaccccacc tccccttccc tgccccacca tggccctggg      480

agatctgttg tcctgtgagg gaaaggggct ccaggctggg ctgcatctga agcccctaga      540

tccagagact tcatttctta ggctatctat aaaatccacc ttcctttctt ttcccaggac      600

ccccataccc tgctcccagc atcgtctgcc tcagctaagc catggggatt gagagaccag      660

gcctggtgcc cagataaact gaccctgggt gaggggacag gggcccagaa tgggcaggta      720

gagactgaat actgaagaag aatcctctgg agtctgttag cagaagcaga tgggccttgc      780

ctgactattg gcaggcggac ctggtggtca gacctcagtg atcctcaggg accagtgaat      840

atttcaggct ggggctgagc atcacctgct cccttggccc cacttatagg gcaaagggga      900

gtctaccagc ctactcactg atgacaaact ggaaaagttt gtcctgtctc tgctctggcc      960

ccacctcgcc ctctccccta cttggaagtt cctttcctga accactgact gccaaagctt     1020

gagggattaa ataaatcatc tggcccaacc tcctaccata gagttgggaa cactgaagaa     1080

aagagactgg cccaaggtca cagagaaggc agggtgaaca ctgtcacagg gagagccagt     1140

gtagaataat ggttaagcca cgcaagctct agaaccactc tatctgagtg caaatcctgg     1200

ctgtcatctg gtacttgctt cctggaacac atctggcctc agactcctga ggccaagaca     1260

cactccctgc cctaagactt gctggttcta tggcaggcag aggcagaaag agccccacca     1320

tcattcccag caaatgggaa aagttcccag ttgcagatat taggggtggg atggggcggg     1380

ggtagtcagc aaccatagac ttagaccctg aagaggcaaa aaaggagggc catgttcttg     1440

ggtcagcaga gcttctactc agcttcttca gcctctagct ctttcctggt gctagtagca     1500

cattctctag tggaggcatc cagatggcag ggagggtcca ggaaacagct gaacatgctg     1560

agcaggcctc ccttgtcccc gctccccatg gccccatgga tcatccggtg ctgcagctca     1620

tctcattggc tggcttctgg ttactcatct ctcctcttct ccatcttccc agcctgtggt     1680

tgccgtggaa acatagaaca gtgacctcac cataggatga gggctgggga gatgctgttc     1740

ttggcaggcg ct                                                         1752


<210>  95
<211>  1255
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KLHL14 promoter

<400>  95
gaaacagcag ccattgatgt agctcagggt tctgtggatc tgtcatttgg agcatgttgg       60

ttctcctgtc tcagctgggc tcattcatgc atctgagttc agctattggg caatctgggg      120

aatgttttgt ccatgtgatg tgtcatcttc taccaggcta gcctgggctt catcacatgg      180

tatctggcag ggctctaaga gggagagttg aaacacacaa ggcctcttga agcttagact      240

cagaattggc acaaggtcgc ttctggcaca ttccattggt caaagcaagt tacaaggcca      300

gctcacattc aaggattagg taagtcgatt ccactcttga tgagaagtct gaaggatttg      360

gaacagtgtc caccatgcag taataaactc aataagtagt agccattatt attctgttag      420

aggttgccag gaaaagtttt atagtggaaa gaaatctgag tttactcttg agaggtaagt      480

ggaatttcta tttgtagaga atgaaggcct ctcaaaaaga cacagcctaa caataggtgc      540

tgcagtttaa cagtggagcg tgtccagaac aggctgccct tttaggcaag ggctagtgtc      600

tttcaggaca gacccaaacc ccaaatacca aaacagaata aagtagtgtc ttagcatact      660

ttgagatcag actgtttctg catttcacag tgctgggggt gggggggagg tgtgggggga      720

agggaaaagc agcataccaa tgtagtgaaa tctggaaaca acagccaaaa aaagtttgca      780

tattgcacag agcacttgaa gatcataaat ctatgcatga gaaagatgta gtggaaattt      840

tgggggggat tagagtttat ttttgtcatc tctgtgagac agctactcat tcatccagat      900

cacagctaag aaaaaagctg gtcacagaaa ttagcagttt cagctcagca gcgaagtcgc      960

cagcctgtga aggcagagag aaattgacta attagcaatg cgcactaaaa cttgacggtt     1020

ctttatagag agagagaaga gagagggaga gagagggaga gggagggagg gggggctcgc     1080

tttttcccct tctttcttcc aaagatgttt gaaatcgcag tcatttacgc tcgacaattt     1140

ttacaatagc cttgagccat aattttgcga gtctctccag catccatccc cctgtatggt     1200

ctctctctac tggccaagca cgaccgtttc tctccccaac cgtggatttc ctatt          1255


<210>  96
<211>  1012
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MMP15 promoter

<400>  96
ccttcctcct ccagggccct ctgcagacca ggctgagatg gaggaacctg ctaaaatcga       60

tggagatgct tctagcctcc cagtaggagg ccccagccat gccttcaacc tggcaggagg      120

tgtagccact cctcatcctt gggttgcagg ttgggtgctg ctgttgtggt ccttcccaga      180

aactgccagt agagggcagc ctgggcatcc taatgcttac tctggttgtt acacaaagaa      240

aatattgggg tcactggcga gcccacccac actcaccaga atctccactg tagtccccct      300

aacaaacagc ccttcacttc ctctcccact tcagcaattt gtattttgat gccattggcc      360

tcagatcaga gtgttttaaa tcatcacgcc ctggcttatc cctggtcgag ccaggacacg      420

gggtgcttca gtgggtctgt caccctctct ccttgaagca tgttgctttt atttatttac      480

ttttactctc accctgctcc tgtaccagca ggggccactt caaagccaag gtacagggtg      540

ataacttgtg gtccagcatc agttttctcc acttctttct cccactcacc cccagcaagg      600

tgcctgggga gacttgagca gatgtttcat tttggcctgg ccagtggctg aaagccaggc      660

ctccaatgca ctgtgacctc tggcttcccc agcagctttc ccagagaggc agagggagtc      720

ttcattcttc ccaggcgggg agaccacgcc ttccctgcct cctccctccg cggggggtcg      780

cgttggaggt cacccccgcc ccctaggcgc tgggttggga gtgacgcggg gtgggctgga      840

gaggtttcct gccgtctggg aagcgtaaac ggaccgccca cctgtcgggc ctcggccgcc      900

cgcacctgct tgtgagaagc ctgcggctgg ggcaccgccc ccggtccccg cccgggtccg      960

cgcattggga gcacactggc cctttaagag cgcggcggcc gcggcgcgcg gg             1012


<210>  97
<211>  1079
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SPARC promoter

<400>  97
caggctacct ctcaggctga ctgagtcatg cagcataggc tgccacgtct ctgggctggc       60

ggggccgtca ttattcctgg cctcactgca gctaaattga agaaacgttt ggtttgtggg      120

ccacgtcaag gaatgtgtaa gagctgccac gttgtcgggt ctgggttatt gggcttttcc      180

cctccttcag agaagatttc caggcgtgtg ggtggggttt cagaagaaaa ttgatgcctg      240

cgtgtgagtg ttccctggac ctggaccagc agcggcaata ttacagaccc gggggttggg      300

gcagactgag ccaatctctg caccgtcaaa gttatggata cagagccctg gaaaaaggct      360

gaaggataag atagctgaca tttatgaagt gcttcattca tgtagcagtg ggccaaatgc      420

gtactttaca cttgaggaag ctgaggctgg aggttgataa catgcctcaa gtcttctaga      480

gttaaataac tttgacccag gacccaagcc cagagttctg actcaaaaac taggcctcct      540

aaacatcctc ttatatgagg ttaaatttca tcttcctctg tttggccttg gcctggttgg      600

tggatgctct gcttcgggga cccagggcca gatgacaatg ggttctttgt gcccttcaga      660

caatgggaag ggctgcctgg ggaaagatac agtaacaagg caacaggctg agtcagcctc      720

caatgtgctt gaaccttctt agcttggcag ccttgacatt cagccagcca cacaaagggt      780

atatcaagga tgataccact agtagcagct tgtcttgtct gtacctctga acaagaaaga      840

ggctgttctg ggtcatccct ccaggcctgt ccagccctgg cactctgtga gtcggtttag      900

gcagcagccc cggaacagat gaggcaggca gggttgggac gtttggtcag gacagcccac      960

caggaggaaa gaaatgaaag acagagacag ctttggctat gggagaagga ggaggccggg     1020

ggaaggagga gacaggagga ggagggacca cggggtggag gggagataga cccagccca      1079


<210>  98
<211>  1223
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TSPAN8 promoter

<400>  98
ccaaggactc ttttttctaa acttcccttc atcttctagt ttgacgccct tggtgggaaa       60

agtgtctgag ataaggaaaa ggcatccttt cagttctctg atactatctt gaagcgaggg      120

atggagaaag gcaaagagag acacaggaga agcgtatccc ctgggaacag gtgtctagtg      180

gagtccagta actcacagtc tctcagttcc gtcagcactg tcccttgggt cgcaaatttc      240

ttccattagc ccttccacca gctgtatttc aaatggggct ggacaataat tgtggccagt      300

ggccttgtgt tgtttgtact tgcggactag tagttctcac ctgtctttct ctgactccta      360

ttagccactg ggatttcagc agctggttca gccaattcta ctcaattcaa cattaagttg      420

cagtgggcta gaactcatgg gccgatttaa caagtgaaat tctaccaaga tacatcaaaa      480

atagcaacag gactagatac tcagctcatt ttgttttatt tgtaatatac cagttgtggc      540

tttagtgcca gtctgattca tctctctact acaaaatgag gctctataaa ggaaaatatt      600

gcaactggag tgaggaattt gaatcttata ggaaggaatt tgtcttctca tgaagacttc      660

agtttaccag aagtatctat tgaggaagtg tttacaagaa aatgtgccat ttagctttat      720

tctaaatttg cataataact gaaccaaaca aaaaaatata gatagataga ttgttctatc      780

tatagataga tagggaacat tggcagtagg tggcagtaag ttcccctgag cacatggagg      840

acacagttaa atgcatttga ggtatgtggg aaatggttta aagcagaatt ttatgccaac      900

ttttagtaac ggaagcctaa caaatgtttg ttctttcaag tgagagaagc aagcaatctg      960

gaactattca taagcttatt ttctgtatcc ttaaacatat tttataatga atgtatgatt     1020

taaatagtaa gttaagtgtc tgggggtact gcacacctcc cttgcataca gtcaaacttc     1080

ttcagggtga tggggaagag gagttatagg ctgccaagca aaattgccaa actggtctca     1140

gaaattcact gcattggaga gcgcgggatc cttgcaacac tgactttagc agttaaacta     1200

gagtggttgg ggatgagtat tct                                             1223


<210>  99
<211>  1087
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VIM promoter

<400>  99
attcacaatg cattccctct gcccaccaca ttaattatca actccttttc ctggcattta       60

ctcatccaac gcatggcccc acgttaactt tcagttccct ttctccccta caaatactcc      120

ataatccagc aaccctggga tccctgagat gatgaagagg accagtgccc attccaggag      180

acatcaccgc agccctgagg aatcggctat gggcaccagc agggcacagt gccacacctc      240

gccaatgcct tgtcctcctt ttccatagtg agtcagtcag caagcgtgta gaagtgagtt      300

ccacactctc ttcctcccat agggagatca cttttctcat tctaagggtt ccaggcacac      360

tcacaatggt ggcatttgct gagcagtggc ttgaataaag ggctctcaga aagcaagatg      420

taactcagag cataggctag ccccaggaat gctcttgggg aatgacctgc agcctcccag      480

tgaaagagag aataaaagaa agccccagca ggcgagctgg gcagtagaga gtcctgtaat      540

tccaccttgg caagcaccat ttgcaagaac gaactgggat aaggtaaaca aaatattgcc      600

taaaagaggc ttgtccaaag aagtcagaat acgctcttca tttacctcta aatttcagta      660

caccataaat ctaaatactc aaaaaaacct gtgccttttc aatcaaggtc aattgcacga      720

attcttttgg aaaacaggac ctatggcatt tcccagacaa atcaccgtga accctgtact      780

gtgcattgct gtcctaaaat ccaaagattc tgtcatttgt gttacataat tgcctttcat      840

ttgaactcat taatcaaatt ggggttttta agcaacacct aattaattct ttaactggct      900

catccactga tcactgagtt ctattttgaa actacggacg tcgagtttcc tctttcaccc      960

agaattttca gatcttgttt aaaaagttgg gtgtggtttc atggggggag ggggaagagc     1020

gagaggagac cagagggacg ggggcgggga ctctgcaaga aaaaccttcc cggtgcaatc     1080

gtgatct                                                               1087


<210>  100
<211>  4634
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BACE2 construct

<400>  100
ctgcgcgctc gctcgctcac tgaggccgcc cgggcgtcgg gcgacctttg gtcgcccggc       60

ctcagtgagc gagcgagcgc gcagagaggg agtggccaac tccatcacta ggggttcctg      120

cggccgcacg cgtggttgtg ctgcgagggc ttcatctcct aagcactaaa tgctaaattc      180

cccctcccac gcccatcgcc actgtcctca cggatcctcg cagcagcttc ccaatcggtc      240

tccctgtctc cagcctcacc acccccaact aagaccattc atgaaaacag agacaaccaa      300

ggagacagtc acccaatgct gtcccttcag cttgcattat tttctgacaa gacagctctg      360

ccatccatgg aagcctgtgt ttgaagatct ctgacataaa ggtcccttgc agagctagac      420

gtgattctaa aattgggaac acaggaataa aaatcaaatc ttgagtagaa gtagctgaaa      480

attgcagtga ttcggggaag cttggcttct aactccccac tgtttgaaga tgggcttgtt      540

tgttttttaa aacagccaac ataattcagc tggaggaggt acaaagaatt ttctattcct      600

tgtttctgta gaaatcgatg gactttagct tgtctaattg tcccccctgc ctttagtatc      660

taaaataaaa taaccctcgt tgcttgcatt actcaacgca tttctgcgtc ttggcgtcta      720

tggctaaacg agtattaatt agacagtccg cagagagctg gctggggata gaaggggagg      780

tgggggagaa gggcagggat cacagcaggg tggactcgtg gccctgattt gggatcctga      840

cagcaactta ctaggtggcc tgagggctgg gtgccagggg aggcagcggg ttccagtagc      900

atctgacctg cattagggac aggggcgcgg cggagggggc gaagggggcg ggggtggggg      960

gaaggtggct ggggtgaagc ccagcttcgc agctagctgt gggcaacaga gggagtaagg     1020

gggggcaatg aggctggggc caggcgccag cagcagccac gccccccacc tcccccgatt     1080

tttagggaaa attctccaaa gctctcgcat cctcctctgc ctccttccac cctccaccct     1140

cccagcctcc actgagacct ctttaaaacc acccaggggc cgccggggga tgaggccggg     1200

gaacgggctg gactgagggc gggggctcgg gggcagcgga cgggaaacgc ctcgaaagca     1260

gccagacccg gcgactgaaa tgaggcggag gagcttggcg aggggaggcg caggctcgga     1320

aaggcgcgcg aggctccagg ctccttcccg atccaccgct ctcctcgctg acctccgagt     1380

cacccccgga agctcccgcc actgccgggc gaatagaccc ccgcggaccc ccaagcgcgc     1440

ggggccgggg ccctagttca ggccctcgct gcccctttaa gggttctcga aactttcccc     1500

ccggtatcag atgagcctcg tcacatccgt tggccgtggc aagctctgag gacccagagg     1560

ccgggcgcgc tccgcccgcg gcgccgcccc ctccgtaact ttcccagtct ccgagggaag     1620

aggcggggtg tggggtgcgg ttaaaaggcg ccacggcggg agacaggtct caccggtcct     1680

acgctgttgc ggccccgcag cgcccgcgcg ctcctctccc cgactcggag cccctcggcg     1740

gcgcccggcc caggacccgc ctaggagcgc aggagcccca gcgcagagac cccaacgccg     1800

agacccccgc cccggccccg ccgcgcttcc tcccgacgca gtttaggacc cttgttcgcg     1860

aagaggtggt gtgcggctga gacccgcgtc ctcaggacgg ttccatcagt gcctcgatcc     1920

tgccccactg gaggaggaag gcagcccgaa cagcgctcac ctaactaaca gctgctgaga     1980

gctgggttcc gtggccatgc acctgggact gccttgagaa gcgtgagcaa accgcccaga     2040

gtagaagcgc tagccaccat ggattggggc acgctgcaga cgatcctggg gggtgtgaac     2100

aaacactcca ccagcattgg aaagatctgg ctcaccgtcc tcttcatttt tcgcattatg     2160

atcctcgttg tggctgcaaa ggaggtgtgg ggagatgagc aggccgactt tgtctgcaac     2220

accctgcagc caggctgcaa gaacgtgtgc tacgatcact acttccccat ctcccacatc     2280

cggctatggg ccctgcagct gatcttcgtg tccacgccag cgctcctagt ggccatgcac     2340

gtggcctacc ggagacatga gaagaagagg aagttcatca agggggagat aaagagtgaa     2400

tttaaggaca tcgaggagat caaaacccag aaggtccgca tcgaaggctc cctgtggtgg     2460

acctacacaa gcagcatctt cttccgggtc atcttcgaag ccgccttcat gtacgtcttc     2520

tatgtcatgt acgacggctt ctccatgcag cggctggtga agtgcaacgc ctggccttgt     2580

cccaacactg tggactgctt tgtgtcccgg cccacggaga agactgtctt cacagtgttc     2640

atgattgcag tgtctggaat ttgcatcctg ctgaatgtca ctgaattgtg ttatttgcta     2700

attagatatt gttctgggaa gtcaaaaaag ccagttggat cccgggctga ctacaaagac     2760

catgacggtg attataaaga tcatgacatc gactacaagg atgacgatga caagtaagaa     2820

atagacagca tgagagggat gaggcaaccc gtgctcagct gtcaaggctc agtcgctagc     2880

atttcccaac acaaagattc tgaccttaaa tgcaaccatt tgaaacccct gtaggcctca     2940

ggtgaaactc cagatgccac aatggagctc tgctccccta aagcctcaaa acaaaggcct     3000

aattctatgc ctgtcttaat tttctttcac ttaagttagt tccactgaga ccccaggctg     3060

ttaggggtta ttggtgtaag gtactttcat attttaaaca gaggatatcg gcatttgttt     3120

ctttctctga ggacaagaga aaaaagccag gttccacaga ggacacagag aaggtttggg     3180

tgtcctcctg gggttctttt tgccaacttt ccccacgtta aaggtgaaca ttggttcttt     3240

catttgcttt ggaagtttta atctctaaca gtggacaaag ttaccagtgc cttaaactct     3300

gttacacttt ttggaagtga aaactttgta gtatgatagg ttattttgat gtaaagatgt     3360

tctggatacc attatatgtt ccccctgttt cagaggctca gattgtaata tgtaaatggt     3420

atgtcattcg ctactatgat ttaatttgaa atatggtctt ttggttatga atactttgca     3480

gcacagctga gaggctgtct gttgtattca ttgtggtcat agcacctaac aacattgtag     3540

cctcaatcga gtgagacaga ctagaagttc ctagtgatgg cttatgatag caaatggcct     3600

catgtcaaat atttagatgt aattttgtgt aagaaataca gactggatgt accaccaact     3660

actacctgta atgacaggcc tgtccaacac atctcccttt tccatgactg tggtagccag     3720

catcggaaag aacgctgatt taaagaggtc gcttgggaat tttattgaca cagtaccatt     3780

taatggggag gacaaaatgg ggcaggggag ggagaagttt ctgtcgttaa aaacagattt     3840

ggaaagactg gactctaaag tctgttgatt aaagatgagc tttgtctact tcaaaagttt     3900

gtttgcttac cccttcagcc tccaattttt taagtgaaaa tatagctaat aacatgtgaa     3960

aagaatagaa gctaaggttt agataaatat tgagcagatc tataggaaga ttgaacctga     4020

atattgccat tatgcttgac atggtttcca aaaaatggta ctccacatat ttcagtgagg     4080

gtaagtattt tcctgttgtc aagaatagca ttgtaaaagc attttgtaat aataaagaat     4140

agctttaatg atatgcttgt aactaaaata attttgtaat gtatcaaata catttaaaac     4200

attaaaatat aatctctata ataagagctc gctgatcagc ctcgactgtg ccttctagtt     4260

gccagccatc tgttgtttgc ccctcccccg tgccttcctt gaccctggaa ggtgccactc     4320

ccactgtcct ttcctaataa aatgaggaaa ttgcatcgca ttgtctgagt aggtgtcatt     4380

ctattctggg gggtggggtg gggcaggaca gcaaggggga ggattgggaa gacaatagca     4440

ggcatgctgg ggatgcggtg ggctctatgg aagcttgaat tcagctgacg tgcctcggac     4500

cgctaggaac ccctagtgat ggagttggcc actccctctc tgcgcgctcg ctcgctcact     4560

gaggccgggc gaccaaaggt cgcccgacgc ccgggctttg cccgggcggc ctcagtgagc     4620

gagcgagcgc gcag                                                       4634


<210>  101
<211>  4697
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DBI2 construct

<400>  101
ctgcgcgctc gctcgctcac tgaggccgcc cgggcgtcgg gcgacctttg gtcgcccggc       60

ctcagtgagc gagcgagcgc gcagagaggg agtggccaac tccatcacta ggggttcctg      120

cggccgcacg cgtggtgaag aaacctgcat ttcttacact tcagtgtact ttccccatat      180

ttaactccaa gatttttgtt aatttgtttg gttttccttt ctcaaacaaa attatgctca      240

gactgaaaac cctagatttg ttccctattg catcttcatt tcttcccaaa cattccataa      300

aacgtgacct acattaagtt agcaagttaa gtctgaaagc gtctaccttc cctggggagg      360

gggaaggtgt aggcagggca gagatttgta gtccagccct cttgccacaa attatgaatt      420

agagaggaat gactttgctt ttttaatgat ctccagagaa ttttccatca tttccctctc      480

ttcacccagc tcctttgcaa ccactgccag agaagtcttc ctttagcttc ttaaacatcg      540

atcctaaaac acttccagac acctgtgctg ctcctttcag ttcccatgga gattaggctg      600

tgtaacaatc tcgcaaagac gttcccctcc gtctcctcat cctcttttca aaccctttta      660

cgatttccca tctcactcag catgacagtc aaagtccctg tgatggccaa cttctgcatc      720

acctagccag tctgccaccg ccaaaactct ccagcctcat cttacacttg ttctctgctt      780

ggaatcttcc ctcccctcct tgaggaactt tctcaaatgt caccttccct caatactccc      840

cctcctccat ttaaaactat aaacttccaa ctctctaagc ccctaaagta ctctatattt      900

aacttattgt ataaactact gtccctactt gtaagttcca agattgcagg gattcacccg      960

ctttgttcac tgctgtctgc caaggtctag aacagtgcaa gttacccaac aggagttcaa     1020

taaacagcca ttcatttaac aaatatttgc tgagcacttc gtcccgtcca agtttgttaa     1080

atcaagacaa ataagacacc gtccctgcct ttaacgcacc agatggagaa atgcaccaca     1140

gacataaatg tgcaatacag gcctgacact acggccacaa gcaagtcaaa gaacgtgcca     1200

aaagttcaga ggaagaagcc tcggcttcgc ctttcgggag accagtccag ctttccacca     1260

tcacgctgct catcagggac catctccggg ggtctcctct agaccccaag ggaggagcgg     1320

gtcccgcccg ccattcccag gtctcagagt ttacttgtcc agagatgcaa cttccggcct     1380

cttcaggccg ggcaagattt aaggaaagaa aagaaacata aggacctccg ttcttcggtc     1440

tccgtcccct ccccttcccc cgcgtgcccc acctgttccc ggcgtcccct tcggctactc     1500

ccggcgtttg cgcaagcggt cccacgtggg ctcgggcggg gctagcgccg cggcgggggc     1560

tgggcacgcc cctagcgcat agctggcttc tgattggctt tccaagctct gaggacccag     1620

aggccgggcg cgctccgccc gcggcgccgc cccctccgta actttcccag tctccgaggg     1680

aagaggcggg gtgtggggtg cggttaaaag gcgccacggc gggagacagg tctcaccggt     1740

gccaaagcgt tgcggccccg cagcgcccgc gcgctcctct ccccgactcg gagcccctcg     1800

gcggcgcccg gcccaggacc cgcctaggag cgcaggagcc ccagcgcaga gaccccaacg     1860

ccgagacccc cgccccggcc ccgccgcgct tcctcccgac gcagtttagg acccttgttc     1920

gcgaagaggt ggtgtgcggc tgagacccgc gtcctcagga cggttccatc agtgcctcga     1980

tcctgcccca ctggaggagg aaggcagccc gaacagcgct cacctaacta acagctgctg     2040

agagctgggt tccgtggcca tgcacctggg actgccttga gaagcgtgag caaaccgccc     2100

agagtagaag cgctagccac catggattgg ggcacgctgc agacgatcct ggggggtgtg     2160

aacaaacact ccaccagcat tggaaagatc tggctcaccg tcctcttcat ttttcgcatt     2220

atgatcctcg ttgtggctgc aaaggaggtg tggggagatg agcaggccga ctttgtctgc     2280

aacaccctgc agccaggctg caagaacgtg tgctacgatc actacttccc catctcccac     2340

atccggctat gggccctgca gctgatcttc gtgtccacgc cagcgctcct agtggccatg     2400

cacgtggcct accggagaca tgagaagaag aggaagttca tcaaggggga gataaagagt     2460

gaatttaagg acatcgagga gatcaaaacc cagaaggtcc gcatcgaagg ctccctgtgg     2520

tggacctaca caagcagcat cttcttccgg gtcatcttcg aagccgcctt catgtacgtc     2580

ttctatgtca tgtacgacgg cttctccatg cagcggctgg tgaagtgcaa cgcctggcct     2640

tgtcccaaca ctgtggactg ctttgtgtcc cggcccacgg agaagactgt cttcacagtg     2700

ttcatgattg cagtgtctgg aatttgcatc ctgctgaatg tcactgaatt gtgttatttg     2760

ctaattagat attgttctgg gaagtcaaaa aagccagttg gatcccgggc tgactacaaa     2820

gaccatgacg gtgattataa agatcatgac atcgactaca aggatgacga tgacaagtaa     2880

gaaatagaca gcatgagagg gatgaggcaa cccgtgctca gctgtcaagg ctcagtcgct     2940

agcatttccc aacacaaaga ttctgacctt aaatgcaacc atttgaaacc cctgtaggcc     3000

tcaggtgaaa ctccagatgc cacaatggag ctctgctccc ctaaagcctc aaaacaaagg     3060

cctaattcta tgcctgtctt aattttcttt cacttaagtt agttccactg agaccccagg     3120

ctgttagggg ttattggtgt aaggtacttt catattttaa acagaggata tcggcatttg     3180

tttctttctc tgaggacaag agaaaaaagc caggttccac agaggacaca gagaaggttt     3240

gggtgtcctc ctggggttct ttttgccaac tttccccacg ttaaaggtga acattggttc     3300

tttcatttgc tttggaagtt ttaatctcta acagtggaca aagttaccag tgccttaaac     3360

tctgttacac tttttggaag tgaaaacttt gtagtatgat aggttatttt gatgtaaaga     3420

tgttctggat accattatat gttccccctg tttcagaggc tcagattgta atatgtaaat     3480

ggtatgtcat tcgctactat gatttaattt gaaatatggt cttttggtta tgaatacttt     3540

gcagcacagc tgagaggctg tctgttgtat tcattgtggt catagcacct aacaacattg     3600

tagcctcaat cgagtgagac agactagaag ttcctagtga tggcttatga tagcaaatgg     3660

cctcatgtca aatatttaga tgtaattttg tgtaagaaat acagactgga tgtaccacca     3720

actactacct gtaatgacag gcctgtccaa cacatctccc ttttccatga ctgtggtagc     3780

cagcatcgga aagaacgctg atttaaagag gtcgcttggg aattttattg acacagtacc     3840

atttaatggg gaggacaaaa tggggcaggg gagggagaag tttctgtcgt taaaaacaga     3900

tttggaaaga ctggactcta aagtctgttg attaaagatg agctttgtct acttcaaaag     3960

tttgtttgct taccccttca gcctccaatt ttttaagtga aaatatagct aataacatgt     4020

gaaaagaata gaagctaagg tttagataaa tattgagcag atctatagga agattgaacc     4080

tgaatattgc cattatgctt gacatggttt ccaaaaaatg gtactccaca tatttcagtg     4140

agggtaagta ttttcctgtt gtcaagaata gcattgtaaa agcattttgt aataataaag     4200

aatagcttta atgatatgct tgtaactaaa ataattttgt aatgtatcaa atacatttaa     4260

aacattaaaa tataatctct ataataagag ctcgctgatc agcctcgact gtgccttcta     4320

gttgccagcc atctgttgtt tgcccctccc ccgtgccttc cttgaccctg gaaggtgcca     4380

ctcccactgt cctttcctaa taaaatgagg aaattgcatc gcattgtctg agtaggtgtc     4440

attctattct ggggggtggg gtggggcagg acagcaaggg ggaggattgg gaagacaata     4500

gcaggcatgc tggggatgcg gtgggctcta tggaagcttg aattcagctg acgtgcctcg     4560

gaccgctagg aacccctagt gatggagttg gccactccct ctctgcgcgc tcgctcgctc     4620

actgaggccg ggcgaccaaa ggtcgcccga cgcccgggct ttgcccgggc ggcctcagtg     4680

agcgagcgag cgcgcag                                                    4697


<210>  102
<211>  4982
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FABP3 construct

<400>  102
ctgcgcgctc gctcgctcac tgaggccgcc cgggcgtcgg gcgacctttg gtcgcccggc       60

ctcagtgagc gagcgagcgc gcagagaggg agtggccaac tccatcacta ggggttcctg      120

cggccgcacg cgtggttacc attctgcctt tcacctgatg ttgctatcct cctccctctt      180

gtttccttcc acccatcctt tccctcccac attactctct tatcccaccc tattttacaa      240

ccagtagcct agggaaaaga gcatagctca aatgaggaag aaggcaggac aggcagtcat      300

ggcttagctg gactgagctg cagtgcttct ccttctgggg aagggggtgc actgtcatct      360

gctactgaca catccctcca aggcactcag ccctgcaggg agcaacctga ttctatgact      420

gacatctaat cttcacattc accttgcagg aaggcaagaa gtgatcccag cctccagatg      480

gaaagatcaa ggcccagaga aggtcagtgg tggttggagg cctgaggtca cacagcagcc      540

aagtctggag tcactagtca aggtgacctt gactagccac cccacctccc cttccctgcc      600

ccaccatggc cctgggagat ctgttgtcct gtgagggaaa ggggctccag gctgggctgc      660

atctgaagcc cctagatcca gagacttcat ttcttaggct atctataaaa tccaccttcc      720

tttcttttcc caggaccccc ataccctgct cccagcatcg tctgcctcag ctaagccatg      780

gggattgaga gaccaggcct ggtgcccaga taaactgacc ctgggtgagg ggacaggggc      840

ccagaatggg caggtagaga ctgaatactg aagaagaatc ctctggagtc tgttagcaga      900

agcagatggg ccttgcctga ctattggcag gcggacctgg tggtcagacc tcagtgatcc      960

tcagggacca gtgaatattt caggctgggg ctgagcatca cctgctccct tggccccact     1020

tatagggcaa aggggagtct accagcctac tcactgatga caaactggaa aagtttgtcc     1080

tgtctctgct ctggccccac ctcgccctct cccctacttg gaagttcctt tcctgaacca     1140

ctgactgcca aagcttgagg gattaaataa atcatctggc ccaacctcct accatagagt     1200

tgggaacact gaagaaaaga gactggccca aggtcacaga gaaggcaggg tgaacactgt     1260

cacagggaga gccagtgtag aataatggtt aagccacgca agctctagaa ccactctatc     1320

tgagtgcaaa tcctggctgt catctggtac ttgcttcctg gaacacatct ggcctcagac     1380

tcctgaggcc aagacacact ccctgcccta agacttgctg gttctatggc aggcagaggc     1440

agaaagagcc ccaccatcat tcccagcaaa tgggaaaagt tcccagttgc agatattagg     1500

ggtgggatgg ggcgggggta gtcagcaacc atagacttag accctgaaga ggcaaaaaag     1560

gagggccatg ttcttgggtc agcagagctt ctactcagct tcttcagcct ctagctcttt     1620

cctggtgcta gtagcacatt ctctagtgga ggcatccaga tggcagggag ggtccaggaa     1680

acagctgaac atgctgagca ggcctccctt gtccccgctc cccatggccc catggatcat     1740

ccggtgctgc agctcatctc attggctggc ttctggttac tcatctctcc tcttctccat     1800

cttcccagcc tgtggttgcc gtggaaacat agaacagtga cctcaccata ggatgagggc     1860

tggggagatg ctgttcttgg caggcgctaa gctctgagga cccagaggcc gggcgcgctc     1920

cgcccgcggc gccgccccct ccgtaacttt cccagtctcc gagggaagag gcggggtgtg     1980

gggtgcggtt aaaaggcgcc acggcgggag acaggtctca ccggtccatc cacgttgcgg     2040

ccccgcagcg cccgcgcgct cctctccccg actcggagcc cctcggcggc gcccggccca     2100

ggacccgcct aggagcgcag gagccccagc gcagagaccc caacgccgag acccccgccc     2160

cggccccgcc gcgcttcctc ccgacgcagt ttaggaccct tgttcgcgaa gaggtggtgt     2220

gcggctgaga cccgcgtcct caggacggtt ccatcagtgc ctcgatcctg ccccactgga     2280

ggaggaaggc agcccgaaca gcgctcacct aactaacagc tgctgagagc tgggttccgt     2340

ggccatgcac ctgggactgc cttgagaagc gtgagcaaac cgcccagagt agaagcgcta     2400

gccaccatgg attggggcac gctgcagacg atcctggggg gtgtgaacaa acactccacc     2460

agcattggaa agatctggct caccgtcctc ttcatttttc gcattatgat cctcgttgtg     2520

gctgcaaagg aggtgtgggg agatgagcag gccgactttg tctgcaacac cctgcagcca     2580

ggctgcaaga acgtgtgcta cgatcactac ttccccatct cccacatccg gctatgggcc     2640

ctgcagctga tcttcgtgtc cacgccagcg ctcctagtgg ccatgcacgt ggcctaccgg     2700

agacatgaga agaagaggaa gttcatcaag ggggagataa agagtgaatt taaggacatc     2760

gaggagatca aaacccagaa ggtccgcatc gaaggctccc tgtggtggac ctacacaagc     2820

agcatcttct tccgggtcat cttcgaagcc gccttcatgt acgtcttcta tgtcatgtac     2880

gacggcttct ccatgcagcg gctggtgaag tgcaacgcct ggccttgtcc caacactgtg     2940

gactgctttg tgtcccggcc cacggagaag actgtcttca cagtgttcat gattgcagtg     3000

tctggaattt gcatcctgct gaatgtcact gaattgtgtt atttgctaat tagatattgt     3060

tctgggaagt caaaaaagcc agttggatcc cgggctgact acaaagacca tgacggtgat     3120

tataaagatc atgacatcga ctacaaggat gacgatgaca agtaagaaat agacagcatg     3180

agagggatga ggcaacccgt gctcagctgt caaggctcag tcgctagcat ttcccaacac     3240

aaagattctg accttaaatg caaccatttg aaacccctgt aggcctcagg tgaaactcca     3300

gatgccacaa tggagctctg ctcccctaaa gcctcaaaac aaaggcctaa ttctatgcct     3360

gtcttaattt tctttcactt aagttagttc cactgagacc ccaggctgtt aggggttatt     3420

ggtgtaaggt actttcatat tttaaacaga ggatatcggc atttgtttct ttctctgagg     3480

acaagagaaa aaagccaggt tccacagagg acacagagaa ggtttgggtg tcctcctggg     3540

gttctttttg ccaactttcc ccacgttaaa ggtgaacatt ggttctttca tttgctttgg     3600

aagttttaat ctctaacagt ggacaaagtt accagtgcct taaactctgt tacacttttt     3660

ggaagtgaaa actttgtagt atgataggtt attttgatgt aaagatgttc tggataccat     3720

tatatgttcc ccctgtttca gaggctcaga ttgtaatatg taaatggtat gtcattcgct     3780

actatgattt aatttgaaat atggtctttt ggttatgaat actttgcagc acagctgaga     3840

ggctgtctgt tgtattcatt gtggtcatag cacctaacaa cattgtagcc tcaatcgagt     3900

gagacagact agaagttcct agtgatggct tatgatagca aatggcctca tgtcaaatat     3960

ttagatgtaa ttttgtgtaa gaaatacaga ctggatgtac caccaactac tacctgtaat     4020

gacaggcctg tccaacacat ctcccttttc catgactgtg gtagccagca tcggaaagaa     4080

cgctgattta aagaggtcgc ttgggaattt tattgacaca gtaccattta atggggagga     4140

caaaatgggg caggggaggg agaagtttct gtcgttaaaa acagatttgg aaagactgga     4200

ctctaaagtc tgttgattaa agatgagctt tgtctacttc aaaagtttgt ttgcttaccc     4260

cttcagcctc caatttttta agtgaaaata tagctaataa catgtgaaaa gaatagaagc     4320

taaggtttag ataaatattg agcagatcta taggaagatt gaacctgaat attgccatta     4380

tgcttgacat ggtttccaaa aaatggtact ccacatattt cagtgagggt aagtattttc     4440

ctgttgtcaa gaatagcatt gtaaaagcat tttgtaataa taaagaatag ctttaatgat     4500

atgcttgtaa ctaaaataat tttgtaatgt atcaaataca tttaaaacat taaaatataa     4560

tctctataat aagagctcgc tgatcagcct cgactgtgcc ttctagttgc cagccatctg     4620

ttgtttgccc ctcccccgtg ccttccttga ccctggaagg tgccactccc actgtccttt     4680

cctaataaaa tgaggaaatt gcatcgcatt gtctgagtag gtgtcattct attctggggg     4740

gtggggtggg gcaggacagc aagggggagg attgggaaga caatagcagg catgctgggg     4800

atgcggtggg ctctatggaa gcttgaattc agctgacgtg cctcggaccg ctaggaaccc     4860

ctagtgatgg agttggccac tccctctctg cgcgctcgct cgctcactga ggccgggcga     4920

ccaaaggtcg cccgacgccc gggctttgcc cgggcggcct cagtgagcga gcgagcgcgc     4980

ag                                                                    4982


<210>  103
<211>  4485
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KLHL14 construct

<400>  103
ctgcgcgctc gctcgctcac tgaggccgcc cgggcgtcgg gcgacctttg gtcgcccggc       60

ctcagtgagc gagcgagcgc gcagagaggg agtggccaac tccatcacta ggggttcctg      120

cggccgcacg cgtggtgaaa cagcagccat tgatgtagct cagggttctg tggatctgtc      180

atttggagca tgttggttct cctgtctcag ctgggctcat tcatgcatct gagttcagct      240

attgggcaat ctggggaatg ttttgtccat gtgatgtgtc atcttctacc aggctagcct      300

gggcttcatc acatggtatc tggcagggct ctaagaggga gagttgaaac acacaaggcc      360

tcttgaagct tagactcaga attggcacaa ggtcgcttct ggcacattcc attggtcaaa      420

gcaagttaca aggccagctc acattcaagg attaggtaag tcgattccac tcttgatgag      480

aagtctgaag gatttggaac agtgtccacc atgcagtaat aaactcaata agtagtagcc      540

attattattc tgttagaggt tgccaggaaa agttttatag tggaaagaaa tctgagttta      600

ctcttgagag gtaagtggaa tttctatttg tagagaatga aggcctctca aaaagacaca      660

gcctaacaat aggtgctgca gtttaacagt ggagcgtgtc cagaacaggc tgccctttta      720

ggcaagggct agtgtctttc aggacagacc caaaccccaa ataccaaaac agaataaagt      780

agtgtcttag catactttga gatcagactg tttctgcatt tcacagtgct gggggtgggg      840

gggaggtgtg gggggaaggg aaaagcagca taccaatgta gtgaaatctg gaaacaacag      900

ccaaaaaaag tttgcatatt gcacagagca cttgaagatc ataaatctat gcatgagaaa      960

gatgtagtgg aaattttggg ggggattaga gtttattttt gtcatctctg tgagacagct     1020

actcattcat ccagatcaca gctaagaaaa aagctggtca cagaaattag cagtttcagc     1080

tcagcagcga agtcgccagc ctgtgaaggc agagagaaat tgactaatta gcaatgcgca     1140

ctaaaacttg acggttcttt atagagagag agaagagaga gggagagaga gggagaggga     1200

gggagggggg gctcgctttt tccccttctt tcttccaaag atgtttgaaa tcgcagtcat     1260

ttacgctcga caatttttac aatagccttg agccataatt ttgcgagtct ctccagcatc     1320

catccccctg tatggtctct ctctactggc caagcacgac cgtttctctc cccaaccgtg     1380

gatttcctat taagctctga ggacccagag gccgggcgcg ctccgcccgc ggcgccgccc     1440

cctccgtaac tttcccagtc tccgagggaa gaggcggggt gtggggtgcg gttaaaaggc     1500

gccacggcgg gagacaggtc tcaccggtcc cgttctgttg cggccccgca gcgcccgcgc     1560

gctcctctcc ccgactcgga gcccctcggc ggcgcccggc ccaggacccg cctaggagcg     1620

caggagcccc agcgcagaga ccccaacgcc gagacccccg ccccggcccc gccgcgcttc     1680

ctcccgacgc agtttaggac ccttgttcgc gaagaggtgg tgtgcggctg agacccgcgt     1740

cctcaggacg gttccatcag tgcctcgatc ctgccccact ggaggaggaa ggcagcccga     1800

acagcgctca cctaactaac agctgctgag agctgggttc cgtggccatg cacctgggac     1860

tgccttgaga agcgtgagca aaccgcccag agtagaagcg ctagccacca tggattgggg     1920

cacgctgcag acgatcctgg ggggtgtgaa caaacactcc accagcattg gaaagatctg     1980

gctcaccgtc ctcttcattt ttcgcattat gatcctcgtt gtggctgcaa aggaggtgtg     2040

gggagatgag caggccgact ttgtctgcaa caccctgcag ccaggctgca agaacgtgtg     2100

ctacgatcac tacttcccca tctcccacat ccggctatgg gccctgcagc tgatcttcgt     2160

gtccacgcca gcgctcctag tggccatgca cgtggcctac cggagacatg agaagaagag     2220

gaagttcatc aagggggaga taaagagtga atttaaggac atcgaggaga tcaaaaccca     2280

gaaggtccgc atcgaaggct ccctgtggtg gacctacaca agcagcatct tcttccgggt     2340

catcttcgaa gccgccttca tgtacgtctt ctatgtcatg tacgacggct tctccatgca     2400

gcggctggtg aagtgcaacg cctggccttg tcccaacact gtggactgct ttgtgtcccg     2460

gcccacggag aagactgtct tcacagtgtt catgattgca gtgtctggaa tttgcatcct     2520

gctgaatgtc actgaattgt gttatttgct aattagatat tgttctggga agtcaaaaaa     2580

gccagttgga tcccgggctg actacaaaga ccatgacggt gattataaag atcatgacat     2640

cgactacaag gatgacgatg acaagtaaga aatagacagc atgagaggga tgaggcaacc     2700

cgtgctcagc tgtcaaggct cagtcgctag catttcccaa cacaaagatt ctgaccttaa     2760

atgcaaccat ttgaaacccc tgtaggcctc aggtgaaact ccagatgcca caatggagct     2820

ctgctcccct aaagcctcaa aacaaaggcc taattctatg cctgtcttaa ttttctttca     2880

cttaagttag ttccactgag accccaggct gttaggggtt attggtgtaa ggtactttca     2940

tattttaaac agaggatatc ggcatttgtt tctttctctg aggacaagag aaaaaagcca     3000

ggttccacag aggacacaga gaaggtttgg gtgtcctcct ggggttcttt ttgccaactt     3060

tccccacgtt aaaggtgaac attggttctt tcatttgctt tggaagtttt aatctctaac     3120

agtggacaaa gttaccagtg ccttaaactc tgttacactt tttggaagtg aaaactttgt     3180

agtatgatag gttattttga tgtaaagatg ttctggatac cattatatgt tccccctgtt     3240

tcagaggctc agattgtaat atgtaaatgg tatgtcattc gctactatga tttaatttga     3300

aatatggtct tttggttatg aatactttgc agcacagctg agaggctgtc tgttgtattc     3360

attgtggtca tagcacctaa caacattgta gcctcaatcg agtgagacag actagaagtt     3420

cctagtgatg gcttatgata gcaaatggcc tcatgtcaaa tatttagatg taattttgtg     3480

taagaaatac agactggatg taccaccaac tactacctgt aatgacaggc ctgtccaaca     3540

catctccctt ttccatgact gtggtagcca gcatcggaaa gaacgctgat ttaaagaggt     3600

cgcttgggaa ttttattgac acagtaccat ttaatgggga ggacaaaatg gggcagggga     3660

gggagaagtt tctgtcgtta aaaacagatt tggaaagact ggactctaaa gtctgttgat     3720

taaagatgag ctttgtctac ttcaaaagtt tgtttgctta ccccttcagc ctccaatttt     3780

ttaagtgaaa atatagctaa taacatgtga aaagaataga agctaaggtt tagataaata     3840

ttgagcagat ctataggaag attgaacctg aatattgcca ttatgcttga catggtttcc     3900

aaaaaatggt actccacata tttcagtgag ggtaagtatt ttcctgttgt caagaatagc     3960

attgtaaaag cattttgtaa taataaagaa tagctttaat gatatgcttg taactaaaat     4020

aattttgtaa tgtatcaaat acatttaaaa cattaaaata taatctctat aataagagct     4080

cgctgatcag cctcgactgt gccttctagt tgccagccat ctgttgtttg cccctccccc     4140

gtgccttcct tgaccctgga aggtgccact cccactgtcc tttcctaata aaatgaggaa     4200

attgcatcgc attgtctgag taggtgtcat tctattctgg ggggtggggt ggggcaggac     4260

agcaaggggg aggattggga agacaatagc aggcatgctg gggatgcggt gggctctatg     4320

gaagcttgaa ttcagctgac gtgcctcgga ccgctaggaa cccctagtga tggagttggc     4380

cactccctct ctgcgcgctc gctcgctcac tgaggccggg cgaccaaagg tcgcccgacg     4440

cccgggcttt gcccgggcgg cctcagtgag cgagcgagcg cgcag                     4485


<210>  104
<211>  4242
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MMP15 construct

<400>  104
ctgcgcgctc gctcgctcac tgaggccgcc cgggcgtcgg gcgacctttg gtcgcccggc       60

ctcagtgagc gagcgagcgc gcagagaggg agtggccaac tccatcacta ggggttcctg      120

cggccgcacg cgtggtcctt cctcctccag ggccctctgc agaccaggct gagatggagg      180

aacctgctaa aatcgatgga gatgcttcta gcctcccagt aggaggcccc agccatgcct      240

tcaacctggc aggaggtgta gccactcctc atccttgggt tgcaggttgg gtgctgctgt      300

tgtggtcctt cccagaaact gccagtagag ggcagcctgg gcatcctaat gcttactctg      360

gttgttacac aaagaaaata ttggggtcac tggcgagccc acccacactc accagaatct      420

ccactgtagt ccccctaaca aacagccctt cacttcctct cccacttcag caatttgtat      480

tttgatgcca ttggcctcag atcagagtgt tttaaatcat cacgccctgg cttatccctg      540

gtcgagccag gacacggggt gcttcagtgg gtctgtcacc ctctctcctt gaagcatgtt      600

gcttttattt atttactttt actctcaccc tgctcctgta ccagcagggg ccacttcaaa      660

gccaaggtac agggtgataa cttgtggtcc agcatcagtt ttctccactt ctttctccca      720

ctcaccccca gcaaggtgcc tggggagact tgagcagatg tttcattttg gcctggccag      780

tggctgaaag ccaggcctcc aatgcactgt gacctctggc ttccccagca gctttcccag      840

agaggcagag ggagtcttca ttcttcccag gcggggagac cacgccttcc ctgcctcctc      900

cctccgcggg gggtcgcgtt ggaggtcacc cccgccccct aggcgctggg ttgggagtga      960

cgcggggtgg gctggagagg tttcctgccg tctgggaagc gtaaacggac cgcccacctg     1020

tcgggcctcg gccgcccgca cctgcttgtg agaagcctgc ggctggggca ccgcccccgg     1080

tccccgcccg ggtccgcgca ttgggagcac actggccctt taagagcgcg gcggccgcgg     1140

cgcgcgggaa gctctgagga cccagaggcc gggcgcgctc cgcccgcggc gccgccccct     1200

ccgtaacttt cccagtctcc gagggaagag gcggggtgtg gggtgcggtt aaaaggcgcc     1260

acggcgggag acaggtctca ccggtttcac tgggttgcgg ccccgcagcg cccgcgcgct     1320

cctctccccg actcggagcc cctcggcggc gcccggccca ggacccgcct aggagcgcag     1380

gagccccagc gcagagaccc caacgccgag acccccgccc cggccccgcc gcgcttcctc     1440

ccgacgcagt ttaggaccct tgttcgcgaa gaggtggtgt gcggctgaga cccgcgtcct     1500

caggacggtt ccatcagtgc ctcgatcctg ccccactgga ggaggaaggc agcccgaaca     1560

gcgctcacct aactaacagc tgctgagagc tgggttccgt ggccatgcac ctgggactgc     1620

cttgagaagc gtgagcaaac cgcccagagt agaagcgcta gccaccatgg attggggcac     1680

gctgcagacg atcctggggg gtgtgaacaa acactccacc agcattggaa agatctggct     1740

caccgtcctc ttcatttttc gcattatgat cctcgttgtg gctgcaaagg aggtgtgggg     1800

agatgagcag gccgactttg tctgcaacac cctgcagcca ggctgcaaga acgtgtgcta     1860

cgatcactac ttccccatct cccacatccg gctatgggcc ctgcagctga tcttcgtgtc     1920

cacgccagcg ctcctagtgg ccatgcacgt ggcctaccgg agacatgaga agaagaggaa     1980

gttcatcaag ggggagataa agagtgaatt taaggacatc gaggagatca aaacccagaa     2040

ggtccgcatc gaaggctccc tgtggtggac ctacacaagc agcatcttct tccgggtcat     2100

cttcgaagcc gccttcatgt acgtcttcta tgtcatgtac gacggcttct ccatgcagcg     2160

gctggtgaag tgcaacgcct ggccttgtcc caacactgtg gactgctttg tgtcccggcc     2220

cacggagaag actgtcttca cagtgttcat gattgcagtg tctggaattt gcatcctgct     2280

gaatgtcact gaattgtgtt atttgctaat tagatattgt tctgggaagt caaaaaagcc     2340

agttggatcc cgggctgact acaaagacca tgacggtgat tataaagatc atgacatcga     2400

ctacaaggat gacgatgaca agtaagaaat agacagcatg agagggatga ggcaacccgt     2460

gctcagctgt caaggctcag tcgctagcat ttcccaacac aaagattctg accttaaatg     2520

caaccatttg aaacccctgt aggcctcagg tgaaactcca gatgccacaa tggagctctg     2580

ctcccctaaa gcctcaaaac aaaggcctaa ttctatgcct gtcttaattt tctttcactt     2640

aagttagttc cactgagacc ccaggctgtt aggggttatt ggtgtaaggt actttcatat     2700

tttaaacaga ggatatcggc atttgtttct ttctctgagg acaagagaaa aaagccaggt     2760

tccacagagg acacagagaa ggtttgggtg tcctcctggg gttctttttg ccaactttcc     2820

ccacgttaaa ggtgaacatt ggttctttca tttgctttgg aagttttaat ctctaacagt     2880

ggacaaagtt accagtgcct taaactctgt tacacttttt ggaagtgaaa actttgtagt     2940

atgataggtt attttgatgt aaagatgttc tggataccat tatatgttcc ccctgtttca     3000

gaggctcaga ttgtaatatg taaatggtat gtcattcgct actatgattt aatttgaaat     3060

atggtctttt ggttatgaat actttgcagc acagctgaga ggctgtctgt tgtattcatt     3120

gtggtcatag cacctaacaa cattgtagcc tcaatcgagt gagacagact agaagttcct     3180

agtgatggct tatgatagca aatggcctca tgtcaaatat ttagatgtaa ttttgtgtaa     3240

gaaatacaga ctggatgtac caccaactac tacctgtaat gacaggcctg tccaacacat     3300

ctcccttttc catgactgtg gtagccagca tcggaaagaa cgctgattta aagaggtcgc     3360

ttgggaattt tattgacaca gtaccattta atggggagga caaaatgggg caggggaggg     3420

agaagtttct gtcgttaaaa acagatttgg aaagactgga ctctaaagtc tgttgattaa     3480

agatgagctt tgtctacttc aaaagtttgt ttgcttaccc cttcagcctc caatttttta     3540

agtgaaaata tagctaataa catgtgaaaa gaatagaagc taaggtttag ataaatattg     3600

agcagatcta taggaagatt gaacctgaat attgccatta tgcttgacat ggtttccaaa     3660

aaatggtact ccacatattt cagtgagggt aagtattttc ctgttgtcaa gaatagcatt     3720

gtaaaagcat tttgtaataa taaagaatag ctttaatgat atgcttgtaa ctaaaataat     3780

tttgtaatgt atcaaataca tttaaaacat taaaatataa tctctataat aagagctcgc     3840

tgatcagcct cgactgtgcc ttctagttgc cagccatctg ttgtttgccc ctcccccgtg     3900

ccttccttga ccctggaagg tgccactccc actgtccttt cctaataaaa tgaggaaatt     3960

gcatcgcatt gtctgagtag gtgtcattct attctggggg gtggggtggg gcaggacagc     4020

aagggggagg attgggaaga caatagcagg catgctgggg atgcggtggg ctctatggaa     4080

gcttgaattc agctgacgtg cctcggaccg ctaggaaccc ctagtgatgg agttggccac     4140

tccctctctg cgcgctcgct cgctcactga ggccgggcga ccaaaggtcg cccgacgccc     4200

gggctttgcc cgggcggcct cagtgagcga gcgagcgcgc ag                        4242


<210>  105
<211>  4309
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SPARC construct

<400>  105
ctgcgcgctc gctcgctcac tgaggccgcc cgggcgtcgg gcgacctttg gtcgcccggc       60

ctcagtgagc gagcgagcgc gcagagaggg agtggccaac tccatcacta ggggttcctg      120

cggccgcacg cgtggtcagg ctacctctca ggctgactga gtcatgcagc ataggctgcc      180

acgtctctgg gctggcgggg ccgtcattat tcctggcctc actgcagcta aattgaagaa      240

acgtttggtt tgtgggccac gtcaaggaat gtgtaagagc tgccacgttg tcgggtctgg      300

gttattgggc ttttcccctc cttcagagaa gatttccagg cgtgtgggtg gggtttcaga      360

agaaaattga tgcctgcgtg tgagtgttcc ctggacctgg accagcagcg gcaatattac      420

agacccgggg gttggggcag actgagccaa tctctgcacc gtcaaagtta tggatacaga      480

gccctggaaa aaggctgaag gataagatag ctgacattta tgaagtgctt cattcatgta      540

gcagtgggcc aaatgcgtac tttacacttg aggaagctga ggctggaggt tgataacatg      600

cctcaagtct tctagagtta aataactttg acccaggacc caagcccaga gttctgactc      660

aaaaactagg cctcctaaac atcctcttat atgaggttaa atttcatctt cctctgtttg      720

gccttggcct ggttggtgga tgctctgctt cggggaccca gggccagatg acaatgggtt      780

ctttgtgccc ttcagacaat gggaagggct gcctggggaa agatacagta acaaggcaac      840

aggctgagtc agcctccaat gtgcttgaac cttcttagct tggcagcctt gacattcagc      900

cagccacaca aagggtatat caaggatgat accactagta gcagcttgtc ttgtctgtac      960

ctctgaacaa gaaagaggct gttctgggtc atccctccag gcctgtccag ccctggcact     1020

ctgtgagtcg gtttaggcag cagccccgga acagatgagg caggcagggt tgggacgttt     1080

ggtcaggaca gcccaccagg aggaaagaaa tgaaagacag agacagcttt ggctatggga     1140

gaaggaggag gccgggggaa ggaggagaca ggaggaggag ggaccacggg gtggagggga     1200

gatagaccca gcccaaagct ctgaggaccc agaggccggg cgcgctccgc ccgcggcgcc     1260

gccccctccg taactttccc agtctccgag ggaagaggcg gggtgtgggg tgcggttaaa     1320

aggcgccacg gcgggagaca ggtctcaccg gtatactctc gttgcggccc cgcagcgccc     1380

gcgcgctcct ctccccgact cggagcccct cggcggcgcc cggcccagga cccgcctagg     1440

agcgcaggag ccccagcgca gagaccccaa cgccgagacc cccgccccgg ccccgccgcg     1500

cttcctcccg acgcagttta ggacccttgt tcgcgaagag gtggtgtgcg gctgagaccc     1560

gcgtcctcag gacggttcca tcagtgcctc gatcctgccc cactggagga ggaaggcagc     1620

ccgaacagcg ctcacctaac taacagctgc tgagagctgg gttccgtggc catgcacctg     1680

ggactgcctt gagaagcgtg agcaaaccgc ccagagtaga agcgctagcc accatggatt     1740

ggggcacgct gcagacgatc ctggggggtg tgaacaaaca ctccaccagc attggaaaga     1800

tctggctcac cgtcctcttc atttttcgca ttatgatcct cgttgtggct gcaaaggagg     1860

tgtggggaga tgagcaggcc gactttgtct gcaacaccct gcagccaggc tgcaagaacg     1920

tgtgctacga tcactacttc cccatctccc acatccggct atgggccctg cagctgatct     1980

tcgtgtccac gccagcgctc ctagtggcca tgcacgtggc ctaccggaga catgagaaga     2040

agaggaagtt catcaagggg gagataaaga gtgaatttaa ggacatcgag gagatcaaaa     2100

cccagaaggt ccgcatcgaa ggctccctgt ggtggaccta cacaagcagc atcttcttcc     2160

gggtcatctt cgaagccgcc ttcatgtacg tcttctatgt catgtacgac ggcttctcca     2220

tgcagcggct ggtgaagtgc aacgcctggc cttgtcccaa cactgtggac tgctttgtgt     2280

cccggcccac ggagaagact gtcttcacag tgttcatgat tgcagtgtct ggaatttgca     2340

tcctgctgaa tgtcactgaa ttgtgttatt tgctaattag atattgttct gggaagtcaa     2400

aaaagccagt tggatcccgg gctgactaca aagaccatga cggtgattat aaagatcatg     2460

acatcgacta caaggatgac gatgacaagt aagaaataga cagcatgaga gggatgaggc     2520

aacccgtgct cagctgtcaa ggctcagtcg ctagcatttc ccaacacaaa gattctgacc     2580

ttaaatgcaa ccatttgaaa cccctgtagg cctcaggtga aactccagat gccacaatgg     2640

agctctgctc ccctaaagcc tcaaaacaaa ggcctaattc tatgcctgtc ttaattttct     2700

ttcacttaag ttagttccac tgagacccca ggctgttagg ggttattggt gtaaggtact     2760

ttcatatttt aaacagagga tatcggcatt tgtttctttc tctgaggaca agagaaaaaa     2820

gccaggttcc acagaggaca cagagaaggt ttgggtgtcc tcctggggtt ctttttgcca     2880

actttcccca cgttaaaggt gaacattggt tctttcattt gctttggaag ttttaatctc     2940

taacagtgga caaagttacc agtgccttaa actctgttac actttttgga agtgaaaact     3000

ttgtagtatg ataggttatt ttgatgtaaa gatgttctgg ataccattat atgttccccc     3060

tgtttcagag gctcagattg taatatgtaa atggtatgtc attcgctact atgatttaat     3120

ttgaaatatg gtcttttggt tatgaatact ttgcagcaca gctgagaggc tgtctgttgt     3180

attcattgtg gtcatagcac ctaacaacat tgtagcctca atcgagtgag acagactaga     3240

agttcctagt gatggcttat gatagcaaat ggcctcatgt caaatattta gatgtaattt     3300

tgtgtaagaa atacagactg gatgtaccac caactactac ctgtaatgac aggcctgtcc     3360

aacacatctc ccttttccat gactgtggta gccagcatcg gaaagaacgc tgatttaaag     3420

aggtcgcttg ggaattttat tgacacagta ccatttaatg gggaggacaa aatggggcag     3480

gggagggaga agtttctgtc gttaaaaaca gatttggaaa gactggactc taaagtctgt     3540

tgattaaaga tgagctttgt ctacttcaaa agtttgtttg cttacccctt cagcctccaa     3600

ttttttaagt gaaaatatag ctaataacat gtgaaaagaa tagaagctaa ggtttagata     3660

aatattgagc agatctatag gaagattgaa cctgaatatt gccattatgc ttgacatggt     3720

ttccaaaaaa tggtactcca catatttcag tgagggtaag tattttcctg ttgtcaagaa     3780

tagcattgta aaagcatttt gtaataataa agaatagctt taatgatatg cttgtaacta     3840

aaataatttt gtaatgtatc aaatacattt aaaacattaa aatataatct ctataataag     3900

agctcgctga tcagcctcga ctgtgccttc tagttgccag ccatctgttg tttgcccctc     3960

ccccgtgcct tccttgaccc tggaaggtgc cactcccact gtcctttcct aataaaatga     4020

ggaaattgca tcgcattgtc tgagtaggtg tcattctatt ctggggggtg gggtggggca     4080

ggacagcaag ggggaggatt gggaagacaa tagcaggcat gctggggatg cggtgggctc     4140

tatggaagct tgaattcagc tgacgtgcct cggaccgcta ggaaccccta gtgatggagt     4200

tggccactcc ctctctgcgc gctcgctcgc tcactgaggc cgggcgacca aaggtcgccc     4260

gacgcccggg ctttgcccgg gcggcctcag tgagcgagcg agcgcgcag                 4309


<210>  106
<211>  4453
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TSPAN8 construct

<400>  106
ctgcgcgctc gctcgctcac tgaggccgcc cgggcgtcgg gcgacctttg gtcgcccggc       60

ctcagtgagc gagcgagcgc gcagagaggg agtggccaac tccatcacta ggggttcctg      120

cggccgcacg cgtggtccaa ggactctttt ttctaaactt cccttcatct tctagtttga      180

cgcccttggt gggaaaagtg tctgagataa ggaaaaggca tcctttcagt tctctgatac      240

tatcttgaag cgagggatgg agaaaggcaa agagagacac aggagaagcg tatcccctgg      300

gaacaggtgt ctagtggagt ccagtaactc acagtctctc agttccgtca gcactgtccc      360

ttgggtcgca aatttcttcc attagccctt ccaccagctg tatttcaaat ggggctggac      420

aataattgtg gccagtggcc ttgtgttgtt tgtacttgcg gactagtagt tctcacctgt      480

ctttctctga ctcctattag ccactgggat ttcagcagct ggttcagcca attctactca      540

attcaacatt aagttgcagt gggctagaac tcatgggccg atttaacaag tgaaattcta      600

ccaagataca tcaaaaatag caacaggact agatactcag ctcattttgt tttatttgta      660

atataccagt tgtggcttta gtgccagtct gattcatctc tctactacaa aatgaggctc      720

tataaaggaa aatattgcaa ctggagtgag gaatttgaat cttataggaa ggaatttgtc      780

ttctcatgaa gacttcagtt taccagaagt atctattgag gaagtgttta caagaaaatg      840

tgccatttag ctttattcta aatttgcata ataactgaac caaacaaaaa aatatagata      900

gatagattgt tctatctata gatagatagg gaacattggc agtaggtggc agtaagttcc      960

cctgagcaca tggaggacac agttaaatgc atttgaggta tgtgggaaat ggtttaaagc     1020

agaattttat gccaactttt agtaacggaa gcctaacaaa tgtttgttct ttcaagtgag     1080

agaagcaagc aatctggaac tattcataag cttattttct gtatccttaa acatatttta     1140

taatgaatgt atgatttaaa tagtaagtta agtgtctggg ggtactgcac acctcccttg     1200

catacagtca aacttcttca gggtgatggg gaagaggagt tataggctgc caagcaaaat     1260

tgccaaactg gtctcagaaa ttcactgcat tggagagcgc gggatccttg caacactgac     1320

tttagcagtt aaactagagt ggttggggat gagtattcta agctctgagg acccagaggc     1380

cgggcgcgct ccgcccgcgg cgccgccccc tccgtaactt tcccagtctc cgagggaaga     1440

ggcggggtgt ggggtgcggt taaaaggcgc cacggcggga gacaggtctc accggtggca     1500

cttcgttgcg gccccgcagc gcccgcgcgc tcctctcccc gactcggagc ccctcggcgg     1560

cgcccggccc aggacccgcc taggagcgca ggagccccag cgcagagacc ccaacgccga     1620

gacccccgcc ccggccccgc cgcgcttcct cccgacgcag tttaggaccc ttgttcgcga     1680

agaggtggtg tgcggctgag acccgcgtcc tcaggacggt tccatcagtg cctcgatcct     1740

gccccactgg aggaggaagg cagcccgaac agcgctcacc taactaacag ctgctgagag     1800

ctgggttccg tggccatgca cctgggactg ccttgagaag cgtgagcaaa ccgcccagag     1860

tagaagcgct agccaccatg gattggggca cgctgcagac gatcctgggg ggtgtgaaca     1920

aacactccac cagcattgga aagatctggc tcaccgtcct cttcattttt cgcattatga     1980

tcctcgttgt ggctgcaaag gaggtgtggg gagatgagca ggccgacttt gtctgcaaca     2040

ccctgcagcc aggctgcaag aacgtgtgct acgatcacta cttccccatc tcccacatcc     2100

ggctatgggc cctgcagctg atcttcgtgt ccacgccagc gctcctagtg gccatgcacg     2160

tggcctaccg gagacatgag aagaagagga agttcatcaa gggggagata aagagtgaat     2220

ttaaggacat cgaggagatc aaaacccaga aggtccgcat cgaaggctcc ctgtggtgga     2280

cctacacaag cagcatcttc ttccgggtca tcttcgaagc cgccttcatg tacgtcttct     2340

atgtcatgta cgacggcttc tccatgcagc ggctggtgaa gtgcaacgcc tggccttgtc     2400

ccaacactgt ggactgcttt gtgtcccggc ccacggagaa gactgtcttc acagtgttca     2460

tgattgcagt gtctggaatt tgcatcctgc tgaatgtcac tgaattgtgt tatttgctaa     2520

ttagatattg ttctgggaag tcaaaaaagc cagttggatc ccgggctgac tacaaagacc     2580

atgacggtga ttataaagat catgacatcg actacaagga tgacgatgac aagtaagaaa     2640

tagacagcat gagagggatg aggcaacccg tgctcagctg tcaaggctca gtcgctagca     2700

tttcccaaca caaagattct gaccttaaat gcaaccattt gaaacccctg taggcctcag     2760

gtgaaactcc agatgccaca atggagctct gctcccctaa agcctcaaaa caaaggccta     2820

attctatgcc tgtcttaatt ttctttcact taagttagtt ccactgagac cccaggctgt     2880

taggggttat tggtgtaagg tactttcata ttttaaacag aggatatcgg catttgtttc     2940

tttctctgag gacaagagaa aaaagccagg ttccacagag gacacagaga aggtttgggt     3000

gtcctcctgg ggttcttttt gccaactttc cccacgttaa aggtgaacat tggttctttc     3060

atttgctttg gaagttttaa tctctaacag tggacaaagt taccagtgcc ttaaactctg     3120

ttacactttt tggaagtgaa aactttgtag tatgataggt tattttgatg taaagatgtt     3180

ctggatacca ttatatgttc cccctgtttc agaggctcag attgtaatat gtaaatggta     3240

tgtcattcgc tactatgatt taatttgaaa tatggtcttt tggttatgaa tactttgcag     3300

cacagctgag aggctgtctg ttgtattcat tgtggtcata gcacctaaca acattgtagc     3360

ctcaatcgag tgagacagac tagaagttcc tagtgatggc ttatgatagc aaatggcctc     3420

atgtcaaata tttagatgta attttgtgta agaaatacag actggatgta ccaccaacta     3480

ctacctgtaa tgacaggcct gtccaacaca tctccctttt ccatgactgt ggtagccagc     3540

atcggaaaga acgctgattt aaagaggtcg cttgggaatt ttattgacac agtaccattt     3600

aatggggagg acaaaatggg gcaggggagg gagaagtttc tgtcgttaaa aacagatttg     3660

gaaagactgg actctaaagt ctgttgatta aagatgagct ttgtctactt caaaagtttg     3720

tttgcttacc ccttcagcct ccaatttttt aagtgaaaat atagctaata acatgtgaaa     3780

agaatagaag ctaaggttta gataaatatt gagcagatct ataggaagat tgaacctgaa     3840

tattgccatt atgcttgaca tggtttccaa aaaatggtac tccacatatt tcagtgaggg     3900

taagtatttt cctgttgtca agaatagcat tgtaaaagca ttttgtaata ataaagaata     3960

gctttaatga tatgcttgta actaaaataa ttttgtaatg tatcaaatac atttaaaaca     4020

ttaaaatata atctctataa taagagctcg ctgatcagcc tcgactgtgc cttctagttg     4080

ccagccatct gttgtttgcc cctcccccgt gccttccttg accctggaag gtgccactcc     4140

cactgtcctt tcctaataaa atgaggaaat tgcatcgcat tgtctgagta ggtgtcattc     4200

tattctgggg ggtggggtgg ggcaggacag caagggggag gattgggaag acaatagcag     4260

gcatgctggg gatgcggtgg gctctatgga agcttgaatt cagctgacgt gcctcggacc     4320

gctaggaacc cctagtgatg gagttggcca ctccctctct gcgcgctcgc tcgctcactg     4380

aggccgggcg accaaaggtc gcccgacgcc cgggctttgc ccgggcggcc tcagtgagcg     4440

agcgagcgcg cag                                                        4453


<210>  107
<211>  4317
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VIM promoter

<400>  107
ctgcgcgctc gctcgctcac tgaggccgcc cgggcgtcgg gcgacctttg gtcgcccggc       60

ctcagtgagc gagcgagcgc gcagagaggg agtggccaac tccatcacta ggggttcctg      120

cggccgcacg cgtggtattc acaatgcatt ccctctgccc accacattaa ttatcaactc      180

cttttcctgg catttactca tccaacgcat ggccccacgt taactttcag ttccctttct      240

cccctacaaa tactccataa tccagcaacc ctgggatccc tgagatgatg aagaggacca      300

gtgcccattc caggagacat caccgcagcc ctgaggaatc ggctatgggc accagcaggg      360

cacagtgcca cacctcgcca atgccttgtc ctccttttcc atagtgagtc agtcagcaag      420

cgtgtagaag tgagttccac actctcttcc tcccataggg agatcacttt tctcattcta      480

agggttccag gcacactcac aatggtggca tttgctgagc agtggcttga ataaagggct      540

ctcagaaagc aagatgtaac tcagagcata ggctagcccc aggaatgctc ttggggaatg      600

acctgcagcc tcccagtgaa agagagaata aaagaaagcc ccagcaggcg agctgggcag      660

tagagagtcc tgtaattcca ccttggcaag caccatttgc aagaacgaac tgggataagg      720

taaacaaaat attgcctaaa agaggcttgt ccaaagaagt cagaatacgc tcttcattta      780

cctctaaatt tcagtacacc ataaatctaa atactcaaaa aaacctgtgc cttttcaatc      840

aaggtcaatt gcacgaattc ttttggaaaa caggacctat ggcatttccc agacaaatca      900

ccgtgaaccc tgtactgtgc attgctgtcc taaaatccaa agattctgtc atttgtgtta      960

cataattgcc tttcatttga actcattaat caaattgggg tttttaagca acacctaatt     1020

aattctttaa ctggctcatc cactgatcac tgagttctat tttgaaacta cggacgtcga     1080

gtttcctctt tcacccagaa ttttcagatc ttgtttaaaa agttgggtgt ggtttcatgg     1140

ggggaggggg aagagcgaga ggagaccaga gggacggggg cggggactct gcaagaaaaa     1200

ccttcccggt gcaatcgtga tctaagctct gaggacccag aggccgggcg cgctccgccc     1260

gcggcgccgc cccctccgta actttcccag tctccgaggg aagaggcggg gtgtggggtg     1320

cggttaaaag gcgccacggc gggagacagg tctcaccggt tttcaggtgt tgcggccccg     1380

cagcgcccgc gcgctcctct ccccgactcg gagcccctcg gcggcgcccg gcccaggacc     1440

cgcctaggag cgcaggagcc ccagcgcaga gaccccaacg ccgagacccc cgccccggcc     1500

ccgccgcgct tcctcccgac gcagtttagg acccttgttc gcgaagaggt ggtgtgcggc     1560

tgagacccgc gtcctcagga cggttccatc agtgcctcga tcctgcccca ctggaggagg     1620

aaggcagccc gaacagcgct cacctaacta acagctgctg agagctgggt tccgtggcca     1680

tgcacctggg actgccttga gaagcgtgag caaaccgccc agagtagaag cgctagccac     1740

catggattgg ggcacgctgc agacgatcct ggggggtgtg aacaaacact ccaccagcat     1800

tggaaagatc tggctcaccg tcctcttcat ttttcgcatt atgatcctcg ttgtggctgc     1860

aaaggaggtg tggggagatg agcaggccga ctttgtctgc aacaccctgc agccaggctg     1920

caagaacgtg tgctacgatc actacttccc catctcccac atccggctat gggccctgca     1980

gctgatcttc gtgtccacgc cagcgctcct agtggccatg cacgtggcct accggagaca     2040

tgagaagaag aggaagttca tcaaggggga gataaagagt gaatttaagg acatcgagga     2100

gatcaaaacc cagaaggtcc gcatcgaagg ctccctgtgg tggacctaca caagcagcat     2160

cttcttccgg gtcatcttcg aagccgcctt catgtacgtc ttctatgtca tgtacgacgg     2220

cttctccatg cagcggctgg tgaagtgcaa cgcctggcct tgtcccaaca ctgtggactg     2280

ctttgtgtcc cggcccacgg agaagactgt cttcacagtg ttcatgattg cagtgtctgg     2340

aatttgcatc ctgctgaatg tcactgaatt gtgttatttg ctaattagat attgttctgg     2400

gaagtcaaaa aagccagttg gatcccgggc tgactacaaa gaccatgacg gtgattataa     2460

agatcatgac atcgactaca aggatgacga tgacaagtaa gaaatagaca gcatgagagg     2520

gatgaggcaa cccgtgctca gctgtcaagg ctcagtcgct agcatttccc aacacaaaga     2580

ttctgacctt aaatgcaacc atttgaaacc cctgtaggcc tcaggtgaaa ctccagatgc     2640

cacaatggag ctctgctccc ctaaagcctc aaaacaaagg cctaattcta tgcctgtctt     2700

aattttcttt cacttaagtt agttccactg agaccccagg ctgttagggg ttattggtgt     2760

aaggtacttt catattttaa acagaggata tcggcatttg tttctttctc tgaggacaag     2820

agaaaaaagc caggttccac agaggacaca gagaaggttt gggtgtcctc ctggggttct     2880

ttttgccaac tttccccacg ttaaaggtga acattggttc tttcatttgc tttggaagtt     2940

ttaatctcta acagtggaca aagttaccag tgccttaaac tctgttacac tttttggaag     3000

tgaaaacttt gtagtatgat aggttatttt gatgtaaaga tgttctggat accattatat     3060

gttccccctg tttcagaggc tcagattgta atatgtaaat ggtatgtcat tcgctactat     3120

gatttaattt gaaatatggt cttttggtta tgaatacttt gcagcacagc tgagaggctg     3180

tctgttgtat tcattgtggt catagcacct aacaacattg tagcctcaat cgagtgagac     3240

agactagaag ttcctagtga tggcttatga tagcaaatgg cctcatgtca aatatttaga     3300

tgtaattttg tgtaagaaat acagactgga tgtaccacca actactacct gtaatgacag     3360

gcctgtccaa cacatctccc ttttccatga ctgtggtagc cagcatcgga aagaacgctg     3420

atttaaagag gtcgcttggg aattttattg acacagtacc atttaatggg gaggacaaaa     3480

tggggcaggg gagggagaag tttctgtcgt taaaaacaga tttggaaaga ctggactcta     3540

aagtctgttg attaaagatg agctttgtct acttcaaaag tttgtttgct taccccttca     3600

gcctccaatt ttttaagtga aaatatagct aataacatgt gaaaagaata gaagctaagg     3660

tttagataaa tattgagcag atctatagga agattgaacc tgaatattgc cattatgctt     3720

gacatggttt ccaaaaaatg gtactccaca tatttcagtg agggtaagta ttttcctgtt     3780

gtcaagaata gcattgtaaa agcattttgt aataataaag aatagcttta atgatatgct     3840

tgtaactaaa ataattttgt aatgtatcaa atacatttaa aacattaaaa tataatctct     3900

ataataagag ctcgctgatc agcctcgact gtgccttcta gttgccagcc atctgttgtt     3960

tgcccctccc ccgtgccttc cttgaccctg gaaggtgcca ctcccactgt cctttcctaa     4020

taaaatgagg aaattgcatc gcattgtctg agtaggtgtc attctattct ggggggtggg     4080

gtggggcagg acagcaaggg ggaggattgg gaagacaata gcaggcatgc tggggatgcg     4140

gtgggctcta tggaagcttg aattcagctg acgtgcctcg gaccgctagg aacccctagt     4200

gatggagttg gccactccct ctctgcgcgc tcgctcgctc actgaggccg ggcgaccaaa     4260

ggtcgcccga cgcccgggct ttgcccgggc ggcctcagtg agcgagcgag cgcgcag        4317


<210>  108
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary barcode

<400>  108
cctacgct                                                                 8


<210>  109
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary barcode

<400>  109
gccaaagc                                                                 8


<210>  110
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary barcode

<400>  110
ccatccac                                                                 8


<210>  111
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary barcode

<400>  111
cccgttct                                                                 8


<210>  112
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary barcode

<400>  112
ttcactgg                                                                 8


<210>  113
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary barcode

<400>  113
atactctc                                                                 8


<210>  114
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary barcode

<400>  114
ggcacttc                                                                 8


<210>  115
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary barcode

<400>  115
tttcaggt                                                                 8


<210>  116
<211>  145
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  116
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg       60

ccgcccgggc aaagcccggg cgtcgggcga cctttggtcg cccggcctca gtgagcgagc      120

gagcgcgcag agagggagtg gccaa                                            145


<210>  117
<211>  678
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary Human GJB2 cDNA coding sequence

<400>  117
atggattggg gcacgctgca gacgatcctg gggggtgtga acaaacactc caccagcatt       60

ggaaagatct ggctcaccgt cctcttcatt tttcgcatta tgatcctcgt tgtggctgca      120

aaggaggtgt ggggagatga gcaggccgac tttgtctgca acaccctgca gccaggctgc      180

aagaacgtgt gctacgatca ctacttcccc atctcccaca tccggctatg ggccctgcag      240

ctgatcttcg tgtccacgcc agcgctccta gtggccatgc acgtggccta ccggagacat      300

gagaagaaga ggaagttcat caagggggag ataaagagtg aatttaagga catcgaggag      360

atcaaaaccc agaaggtccg catcgaaggc tccctgtggt ggacctacac aagcagcatc      420

ttcttccggg tcatcttcga agccgccttc atgtacgtct tctatgtcat gtacgacggc      480

ttctccatgc agcggctggt gaagtgcaac gcctggcctt gtcccaacac tgtggactgc      540

tttgtgtccc ggcccacgga gaagactgtc ttcacagtgt tcatgattgc agtgtctgga      600

atttgcatcc tgctgaatgt cactgaattg tgttatttgc taattagata ttgttctggg      660

aagtcaaaaa agccagtt                                                    678


<210>  118
<211>  681
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary Human GJB2 cDNA coding sequence

<400>  118
atggattggg gcacgctgca gacgatcctg gggggtgtga acaaacactc caccagcatt       60

ggaaagatct ggctcaccgt cctcttcatt tttcgcatta tgatcctcgt tgtggctgca      120

aaggaggtgt ggggagatga gcaggccgac tttgtctgca acaccctgca gccaggctgc      180

aagaacgtgt gctacgatca ctacttcccc atctcccaca tccggctatg ggccctgcag      240

ctgatcttcg tgtccacgcc agcgctccta gtggccatgc acgtggccta ccggagacat      300

gagaagaaga ggaagttcat caagggggag ataaagagtg aatttaagga catcgaggag      360

atcaaaaccc agaaggtccg catcgaaggc tccctgtggt ggacctacac aagcagcatc      420

ttcttccggg tcatcttcga agccgccttc atgtacgtct tctatgtcat gtacgacggc      480

ttctccatgc agcggctggt gaagtgcaac gcctggcctt gtcccaacac tgtggactgc      540

tttgtgtccc ggcccacgga gaagactgtc ttcacagtgt tcatgattgc agtgtctgga      600

atttgcatcc tgctgaatgt cactgaattg tgttatttgc taattagata ttgttctggg      660

aagtcaaaaa agccagttta a                                                681


<210>  119
<211>  3074
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary spliced Human GJB2 isoform 1 cDNA including 
       untranslated regions

<400>  119
gttgcggccc cgcagcgccc gcgcgctcct ctccccgact cggagcccct cggcggcgcc       60

cggcccagga cccgcctagg agcgcaggag ccccagcgca gagaccccaa cgccgagacc      120

cccgccccgg ccccgccgcg cttcctcccg acgcagagca aaccgcccag agtagaagat      180

ggattggggc acgctgcaga cgatcctggg gggtgtgaac aaacactcca ccagcattgg      240

aaagatctgg ctcaccgtcc tcttcatttt tcgcattatg atcctcgttg tggctgcaaa      300

ggaggtgtgg ggagatgagc aggccgactt tgtctgcaac accctgcagc caggctgcaa      360

gaacgtgtgc tacgatcact acttccccat ctcccacatc cggctatggg ccctgcagct      420

gatcttcgtg tccacgccag cgctcctagt ggccatgcac gtggcctacc ggagacatga      480

gaagaagagg aagttcatca agggggagat aaagagtgaa tttaaggaca tcgaggagat      540

caaaacccag aaggtccgca tcgaaggctc cctgtggtgg acctacacaa gcagcatctt      600

cttccgggtc atcttcgaag ccgccttcat gtacgtcttc tatgtcatgt acgacggctt      660

ctccatgcag cggctggtga agtgcaacgc ctggccttgt cccaacactg tggactgctt      720

tgtgtcccgg cccacggaga agactgtctt cacagtgttc atgattgcag tgtctggaat      780

ttgcgttgcg gccccgcagc gcccgcgcgc tcctctcccc gactcggagc ccctcggcgg      840

cgcccggccc aggacccgcc taggagcgca ggagccccag cgcagagacc ccaacgccga      900

gacccccgcc ccggccccgc cgcgcttcct cccgacgcag agcaaaccgc ccagagtaga      960

agatggattg gggcacgctg cagacgatcc tggggggtgt gaacaaacac tccaccagca     1020

ttggaaagat ctggctcacc gtcctcttca tttttcgcat tatgatcctc gttgtggctg     1080

caaaggaggt gtggggagat gagcaggccg actttgtctg caacaccctg cagccaggct     1140

gcaagaacgt gtgctacgat cactacttcc ccatctccca catccggcta tgggccctgc     1200

agctgatctt cgtgtccacg ccagcgctcc tagtggccat gcacgtggcc taccggagac     1260

atgagaagaa gaggaagttc atcaaggggg agataaagag tgaatttaag gacatcgagg     1320

agatcaaaac ccagaaggtc cgcatcgaag gctccctgtg gtggacctac acaagcagca     1380

tcttcttccg ggtcatcttc gaagccgcct tcatgtacgt cttctatgtc atgtacgacg     1440

gcttctccat gcagcggctg gtgaagtgca acgcctggcc ttgtcccaac actgtggact     1500

gctttgtgtc ccggcccacg gagaagactg tcttcacagt gttcatgatt gcagtgtctg     1560

gaatttgcat cctgctgaat gtcactgaat tgtgttattt gctaattaga tattgttctg     1620

ggaagtcaaa aaagccagtt taacgcattg cccagttgtt agattaagaa atagacagca     1680

tgagagggat gaggcaaccc gtgctcagct gtcaaggctc agtcgctagc atttcccaac     1740

acaaagattc tgaccttaaa tgcaaccatt tgaaacccct gtaggcctca ggtgaaactc     1800

cagatgccac aatggagctc tgctccccta aagcctcaaa acaaaggcct aattctatgc     1860

ctgtcttaat tttctttcac ttaagttagt tccactgaga ccccaggctg ttaggggtta     1920

ttggtgtaag gtactttcat attttaaaca gaggatatcg gcatttgttt ctttctctga     1980

ggacaagaga aaaaagccag gttccacaga ggacacagag aaggtttggg tgtcctcctg     2040

gggttctttt tgccaacttt ccccacgtta aaggtgaaca ttggttcttt catttgcttt     2100

ggaagtttta atctctaaca gtggacaaag ttaccagtgc cttaaactct gttacacttt     2160

ttggaagtga aaactttgta gtatgatagg ttattttgat gtaaagatgt tctggatacc     2220

attatatgtt ccccctgttt cagaggctca gattgtaata tgtaaatggt atgtcattcg     2280

ctactatgat ttaatttgaa atatggtctt ttggttatga atactttgca gcacagctga     2340

gaggctgtct gttgtattca ttgtggtcat agcacctaac aacattgtag cctcaatcga     2400

gtgagacaga ctagaagttc ctagtgatgg cttatgatag caaatggcct catgtcaaat     2460

atttagatgt aattttgtgt aagaaataca gactggatgt accaccaact actacctgta     2520

atgacaggcc tgtccaacac atctcccttt tccatgactg tggtagccag catcggaaag     2580

aacgctgatt taaagaggtc gcttgggaat tttattgaca cagtaccatt taatggggag     2640

gacaaaatgg ggcaggggag ggagaagttt ctgtcgttaa aaacagattt ggaaagactg     2700

gactctaaag tctgttgatt aaagatgagc tttgtctact tcaaaagttt gtttgcttac     2760

cccttcagcc tccaattttt taagtgaaaa tatagctaat aacatgtgaa aagaatagaa     2820

gctaaggttt agataaatat tgagcagatc tataggaaga ttgaacctga atattgccat     2880

tatgcttgac atggtttcca aaaaatggta ctccacatat ttcagtgagg gtaagtattt     2940

tcctgttgtc aagaatagca ttgtaaaagc attttgtaat aataaagaat agctttaatg     3000

atatgcttgt aactaaaata attttgtaat gtatcaaata catttaaaac attaaaatat     3060

aatctctata ataa                                                       3074


<210>  120
<211>  2318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary spliced Human GJB2 isoform X1 cDNA including 
       untranslated regions

<400>  120
tttaggaccc ttgttcgcga agaggtggtg tgcggctgag acccgcgtcc tcaggacggt       60

tccatcagtg cctcgatcct gccccactgg aggaggaagg cagcccgaac agcgctcacc      120

taactaacag ctgctgagag ctgggttccg tggccatgca cctgggactg ccttgagaag      180

cgtgagcaaa ccgcccagag tagaagatgg attggggcac gctgcagacg atcctggggg      240

gtgtgaacaa acactccacc agcattggaa agatctggct caccgtcctc ttcatttttc      300

gcattatgat cctcgttgtg gctgcaaagg aggtgtgggg agatgagcag gccgactttg      360

tctgcaacac cctgcagcca ggctgcaaga acgtgtgcta cgatcactac ttccccatct      420

cccacatccg gctatgggcc ctgcagctga tcttcgtgtc cacgccagcg ctcctagtgg      480

ccatgcacgt ggcctaccgg agacatgaga agaagaggaa gttcatcaag ggggagataa      540

agagtgaatt taaggacatc gaggagatca aaacccagaa ggtccgcatc gaaggctccc      600

tgtggtggac ctacacaagc agcatcttct tccgggtcat cttcgaagcc gccttcatgt      660

acgtcttcta tgtcatgtac gacggcttct ccatgcagcg gctggtgaag tgcaacgcct      720

ggccttgtcc caacactgtg gactgctttg tgtcccggcc cacggagaag actgtcttca      780

cagtgttcat gattgcagtg tctggaattt gcatcctgct gaatgtcact gaattgtgtt      840

atttgctaat tagatattgt tctgggaagt caaaaaagcc agtttaacgc attgcccagt      900

tgttagatta agaaatagac agcatgagag ggatgaggca acccgtgctc agctgtcaag      960

gctcagtcgc tagcatttcc caacacaaag attctgacct taaatgcaac catttgaaac     1020

ccctgtaggc ctcaggtgaa actccagatg ccacaatgga gctctgctcc cctaaagcct     1080

caaaacaaag gcctaattct atgcctgtct taattttctt tcacttaagt tagttccact     1140

gagaccccag gctgttaggg gttattggtg taaggtactt tcatatttta aacagaggat     1200

atcggcattt gtttctttct ctgaggacaa gagaaaaaag ccaggttcca cagaggacac     1260

agagaaggtt tgggtgtcct cctggggttc tttttgccaa ctttccccac gttaaaggtg     1320

aacattggtt ctttcatttg ctttggaagt tttaatctct aacagtggac aaagttacca     1380

gtgccttaaa ctctgttaca ctttttggaa gtgaaaactt tgtagtatga taggttattt     1440

tgatgtaaag atgttctgga taccattata tgttccccct gtttcagagg ctcagattgt     1500

aatatgtaaa tggtatgtca ttcgctacta tgatttaatt tgaaatatgg tcttttggtt     1560

atgaatactt tgcagcacag ctgagaggct gtctgttgta ttcattgtgg tcatagcacc     1620

taacaacatt gtagcctcaa tcgagtgaga cagactagaa gttcctagtg atggcttatg     1680

atagcaaatg gcctcatgtc aaatatttag atgtaatttt gtgtaagaaa tacagactgg     1740

atgtaccacc aactactacc tgtaatgaca ggcctgtcca acacatctcc cttttccatg     1800

actgtggtag ccagcatcgg aaagaacgct gatttaaaga ggtcgcttgg gaattttatt     1860

gacacagtac catttaatgg ggaggacaaa atggggcagg ggagggagaa gtttctgtcg     1920

ttaaaaacag atttggaaag actggactct aaagtctgtt gattaaagat gagctttgtc     1980

tacttcaaaa gtttgtttgc ttaccccttc agcctccaat tttttaagtg aaaatatagc     2040

taataacatg tgaaaagaat agaagctaag gtttagataa atattgagca gatctatagg     2100

aagattgaac ctgaatattg ccattatgct tgacatggtt tccaaaaaat ggtactccac     2160

atatttcagt gagggtaagt attttcctgt tgtcaagaat agcattgtaa aagcattttg     2220

taataataaa gaatagcttt aatgatatgc ttgtaactaa aataattttg taatgtatca     2280

aatacattta aaacattaaa atataatctc tataataa                             2318


<210>  121
<211>  5469
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary Human GJB2 Genomic DNA sequence

<400>  121
gttgcggccc cgcagcgccc gcgcgctcct ctccccgact cggagcccct cggcggcgcc       60

cggcccagga cccgcctagg agcgcaggag ccccagcgca gagaccccaa cgccgagacc      120

cccgccccgg ccccgccgcg cttcctcccg acgcaggtga gcccgccggc cccggactgc      180

ccggccagga acctggcgcg gggagggacc gcgagaccca gagcggttgc ccggccgcgt      240

gggtctcggg gaaccggggg gctggaccaa cacacgtcct tgggccgggg ggcgggggcc      300

gccttctgga gcgggcgttt ctgcggccga gctccggagc tggaatgggg cggccgggga      360

agtggacgcg atggcaccgc ccggggtgcg agtggggccg ggcgcgcgcg ggaggggaaa      420

aaggcgcggg cgagccgcca gcgcgaggtt tgtggtgtcg ccgatgtccc ttcggggtac      480

tctagcgcag ccgcctggct acttgaccca ctgccaccaa acgttttaaa ttcaccgaaa      540

gcttagcttc gaagcaaagc tccgtttcgc cggtgaagca ggaagccttc gctgcaggaa      600

ctgaccttta cctcttggag cggcttctgc agaaaaatcc ccgggcagag atttgggcgg      660

agtttgccta gaactaacgc ggagccagcc gatcccggcc taccccgggg ccaagatttc      720

agtggcttcc ctttttccta aacacttcac gagggtctgt ttccgggctg tgctccccgc      780

ctagaaggaa aatttttagg acccttgttc gcgaagaggt ggtgtgcggc tgagacccgc      840

gtcctcagga cggttccatc agtgcctcga tcctgcccca ctggaggagg aaggcagccc      900

gaacagcgct cacctaacta acagctgctg agagctgggt tccgtggcca tgcacctggg      960

actgccttga gaagcgtggt acggccgtgt ccccatgtga ccttagagtc cctttcgaaa     1020

ctgctgtgca cagtcggtca caatttcaga cactggtgag aagggtggag gaaccctctg     1080

gggacagcca ggcaaggtcg accacccatc acctaagggt ggagaaattt aaggggtgaa     1140

gagtcccttt tgccttttct ggatcctggt gattcaccta gtgtcttccc taaggaactg     1200

aaccaactcc tccgctggcc tctggcagcc ctccaggcgg tgcaggatgg cgtgggcccg     1260

gtaggaagct gcatgtaacc gcccagggtc gggaggccag gagggcagct cctcctctga     1320

cttgaatatt gaaaacaact tcgtcctgct tctgagcccc tcttaaccca tgacccccta     1380

gcccattggg gagtaaatct taatttactc ctcttcctga aaaaggatct ttaaaacagg     1440

tagcttcaac tcaagcttta taaaataaca atatagggtt tctcggaact gtatttttct     1500

cagctgatgg taactggaca ggtctgtaga agggtgtatg acctgggttt ggcaggtgga     1560

agagggcaaa ggataaaccc ctcctcctgc agccccatat tcttggccag gtgtattgtt     1620

gtaaaccagg agagagttta cttcggggag tatcctgttt tccactcagt gagggccaat     1680

gaagaatgtc taattccata agatgctttt gttaaaatcg gaatgttgct gtcctcggtg     1740

gttctgctgt tgggacggga ctggcctgag ctgtgggtgc tgtagcagga caaccagctc     1800

acctaagggc ctcccagtct ggattatcaa tgggtcagtg ctgaacctgg gctaaaatat     1860

tgttttttcc aatgatgttg tctttcccaa gctcagtgaa gctaaatgtt tcacaggcct     1920

atgtcaatct gatgtaactt tcgtggccac ctctctcctg ttagcctctg accaaggtgg     1980

cactggatgg tttctgcctg accttggtgc cccgtggcag cgactgtggg tcatgaaaga     2040

cattcactac gagcctgctt ctggagtcca tcagaaaacg ggatgcaact tgcctaaaat     2100

gaggagagga ggatgctttt aagaaaaaga agaaggagga ttcactacca gctctgaagg     2160

gtggaaaaga gatgattcat ccggattgtg gagagggtgg aatcttgttt aggagagcgt     2220

tggttgtggc aggcagggtg taactatgaa tcagtgaaga caattcacat cctgggatga     2280

aaagaaggcc atgggctcac aggagattat ccactggcct ctccacatcc gcttgcagta     2340

aggagtgtgg gactctccca agcttcagcg ctgaactgca atgcagtgac gtcgcttagc     2400

tgggccagta accgagggag ttgaattttc tgtcatttta aaataatgtg tcttttaaga     2460

aacactttga aattaaaacc acagcccaca attataatgc actgttgcag cacttatcaa     2520

aacagatatg ctaactgagc catcagtgcc agcctgacag tgaggccacc aagccatcca     2580

caaagcctac acgaaagtct gtgctcacag tggcttttct ccatgaagag ggcattccta     2640

acctcttcct ttcacgtagg aggaagcaag gtcctttgta aaattttaac tcggggtgcc     2700

tcaaatgtaa acttaaccac tggtaacaac agtttcactg ctacatgcca cgtctgtgaa     2760

aattcattca agacattaag gaaagtggct cagcagagag actagacatc ttatcctcac     2820

ggttctcctg tacttggcct ctcagccttt gagcaaggtt ggcccaagct agtatcggcc     2880

ccagtggtac agccaaaact tgagactgca aatggatgca gctgttgaac gctgagtaac     2940

ttctgcagag tcaggaagac ccaaggaagc tctgcagagg atgcaggggt acggtcagaa     3000

cccctgagtg cctttcagct aacgaggact ttatgacact ccccagcaca gcaaattttt     3060

atgatgtgtt taaagattgg gtgaattact caggtgaaca agctactttt tatcagagaa     3120

cacctaaaaa cacgttcaag agggtttggg aactatacat ttaatcctat gacaaactaa     3180

gttggttctg tcttcacctg ttttggtgag gttgtgtaag agttggtgtt tgctcaggaa     3240

gagatttaag catgcttgct tacccagact cagagaagtc tccctgttct gtcctagcta     3300

gtgattcctg tgttgtgtgc attcgtcttt tccagagcaa accgcccaga gtagaagatg     3360

gattggggca cgctgcagac gatcctgggg ggtgtgaaca aacactccac cagcattgga     3420

aagatctggc tcaccgtcct cttcattttt cgcattatga tcctcgttgt ggctgcaaag     3480

gaggtgtggg gagatgagca ggccgacttt gtctgcaaca ccctgcagcc aggctgcaag     3540

aacgtgtgct acgatcacta cttccccatc tcccacatcc ggctatgggc cctgcagctg     3600

atcttcgtgt ccacgccagc gctcctagtg gccatgcacg tggcctaccg gagacatgag     3660

aagaagagga agttcatcaa gggggagata aagagtgaat ttaaggacat cgaggagatc     3720

aaaacccaga aggtccgcat cgaaggctcc ctgtggtgga cctacacaag cagcatcttc     3780

ttccgggtca tcttcgaagc cgccttcatg tacgtcttct atgtcatgta cgacggcttc     3840

tccatgcagc ggctggtgaa gtgcaacgcc tggccttgtc ccaacactgt ggactgcttt     3900

gtgtcccggc ccacggagaa gactgtcttc acagtgttca tgattgcagt gtctggaatt     3960

tgcatcctgc tgaatgtcac tgaattgtgt tatttgctaa ttagatattg ttctgggaag     4020

tcaaaaaagc cagtttaacg cattgcccag ttgttagatt aagaaataga cagcatgaga     4080

gggatgaggc aacccgtgct cagctgtcaa ggctcagtcg ctagcatttc ccaacacaaa     4140

gattctgacc ttaaatgcaa ccatttgaaa cccctgtagg cctcaggtga aactccagat     4200

gccacaatgg agctctgctc ccctaaagcc tcaaaacaaa ggcctaattc tatgcctgtc     4260

ttaattttct ttcacttaag ttagttccac tgagacccca ggctgttagg ggttattggt     4320

gtaaggtact ttcatatttt aaacagagga tatcggcatt tgtttctttc tctgaggaca     4380

agagaaaaaa gccaggttcc acagaggaca cagagaaggt ttgggtgtcc tcctggggtt     4440

ctttttgcca actttcccca cgttaaaggt gaacattggt tctttcattt gctttggaag     4500

ttttaatctc taacagtgga caaagttacc agtgccttaa actctgttac actttttgga     4560

agtgaaaact ttgtagtatg ataggttatt ttgatgtaaa gatgttctgg ataccattat     4620

atgttccccc tgtttcagag gctcagattg taatatgtaa atggtatgtc attcgctact     4680

atgatttaat ttgaaatatg gtcttttggt tatgaatact ttgcagcaca gctgagaggc     4740

tgtctgttgt attcattgtg gtcatagcac ctaacaacat tgtagcctca atcgagtgag     4800

acagactaga agttcctagt gatggcttat gatagcaaat ggcctcatgt caaatattta     4860

gatgtaattt tgtgtaagaa atacagactg gatgtaccac caactactac ctgtaatgac     4920

aggcctgtcc aacacatctc ccttttccat gactgtggta gccagcatcg gaaagaacgc     4980

tgatttaaag aggtcgcttg ggaattttat tgacacagta ccatttaatg gggaggacaa     5040

aatggggcag gggagggaga agtttctgtc gttaaaaaca gatttggaaa gactggactc     5100

taaagtctgt tgattaaaga tgagctttgt ctacttcaaa agtttgtttg cttacccctt     5160

cagcctccaa ttttttaagt gaaaatatag ctaataacat gtgaaaagaa tagaagctaa     5220

ggtttagata aatattgagc agatctatag gaagattgaa cctgaatatt gccattatgc     5280

ttgacatggt ttccaaaaaa tggtactcca catatttcag tgagggtaag tattttcctg     5340

ttgtcaagaa tagcattgta aaagcatttt gtaataataa agaatagctt taatgatatg     5400

cttgtaacta aaataatttt gtaatgtatc aaatacattt aaaacattaa aatataatct     5460

ctataataa                                                             5469


<210>  122
<211>  12513
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary expanded Human GJB2 Genomic DNA Sequence including 
       certain regulatory regions

<400>  122
gactgtgaac ttaaggcaca gcagagctgg ggctgctctt aaggccctgc tgtctctcct       60

cttagtaaca acaccatttc acatgaagtg acagtggtat cttttgttgc cctggaaatg      120

gaatacaaca atggctttcc aacttttctg tggcagagac ctacagacag aagtacattt      180

tacactggat ccaggacaca catcagtctg aaaacacaca catgaaccaa acgtttccta      240

aagcattact tatccttgct aatagcaaca cattctcata ttcttttata cttcatttaa      300

tttcatataa aaaagaaaag gaaaggaaag aaatctattt ctcagcccat taataaggtc      360

aggagcagca acaccagact agaagaaaag cttacctata gatttttctg ccacctcttg      420

agtgcgtcca gctttccgac aagtctcagt gccatctact gtgcgctctg ggtattgcaa      480

ttgctttttt tttttttttt tttttttttt tagaatgaga ctaagtcaga gaacacaaag      540

aacttctttc cccacagtgg agatggctct gaaagcgttt aaggaatagc ttagatgagt      600

ggctaacaca ttctcccggt tctgaattct aagaccacag actccatgtc cagtccccaa      660

agagaggctt tgcaagctac agaatacccc tctgactggg acctcaggag ctaaactgac      720

cacgtaattg gttctagaaa gtgaaacgtt ttaatttgaa acatccaaat gagcattttg      780

tgaaaagcta ctgccgtcca tcaaatacaa cacagccagg gagtcatcgc tctattgccc      840

ttgtcaatcc tacatctata gttttttttg ctacagcagt tcatgagtgt tgactctatt      900

ctaacttgtt ccagaagccc ttcaagatga tagatagcac aatatttttg tagccagagc      960

tagaatgtag agctcttttt ggcttccttg tgaatgatcc agaatttcca tgttggcaag     1020

ccaccataat ttacagaatt tactttttat attcaataga agtaaaaaaa atttacctat     1080

ttaaggagtt atagctctgg attcatttct gaccaaaatg tgctttttga cacaaataca     1140

attggaaatg tctttgtaat ttatccacag tctgcctaga taatcataaa agaactgcat     1200

ggatatattt gtgagtaaga gcacgtgtcc attcagcaaa accaaggaga tcaactaatt     1260

ctaccattgc cttgaaacgg agacacatct agcagtttga atttccccca aaagattgta     1320

tgtgtgaaaa taagaataga atgaggaaaa tttaaaagcc tatataataa tttcagtcac     1380

aacttggcaa ttagaatttt atgagatgtc tttaatttgg aagcaaagaa caattaaatt     1440

attgaaggct ggaatttttt tttaactctt tgaatggaac aacagatttt ccccaaaaga     1500

tttgacttta acaattttca gaaaacataa gtcagggtgt ggttcaatta cacagagaga     1560

aattgtagtg aaatagtgtt ccctgtaata attacccaca aaggagcaca gtggagccac     1620

tcctgcatta aaattacagt atcatatgta agttattatt aattaaccag agatgccagg     1680

agcttgtcag tttccaactg ctattttgag gagagctaaa gtttctcttt ttttgccagt     1740

tattattatt attaatattt caacagcaag gcaagaaaag ggaatgtggt ccattaacta     1800

atggctcttg aaaagacact caatgaatcc aacttgccct aaaactgcca agtggtagga     1860

cagtctcttc gcgtcttgca tcattttctg ccatcaccta cgtgtgattc gtgagtcgga     1920

aattcaacca agacatgttt aatgtatatt tagagcattc ttcccggcgg gaattcacgg     1980

tgccattcca tcaggcagtt ggcaagcagt cacttgaaat attaagaaat atgatttgtg     2040

tcacactgat ttattgcaaa acagcaactt ctttcttttt ggttcattta taaaacaact     2100

gtcaaattaa aatgccaaat agctttaaac attagcattt tcaccttata accttacaag     2160

tgcatcactt taaacatctg agtaaaagtt cagctcgatg acaatcacct gggatttacc     2220

tgcatggtac taagcatata tgtaaaaata ttactgatgg gtatctctgg cactctgaag     2280

tgacaaagtg tagccttcac agatctttgt cagttaatca tcaatagtta cctgaaaagt     2340

gcccacttgc catcattcaa gatcaaccag gcagacacca cagtgagttt tccatcaaaa     2400

aaccttctct atctggtcag tctctgcacg tcaatgagac aaaggtgtat gctgcacgca     2460

gcagtactat cctaagctcc ctgtgtcctc accatggggc tgggtggctg gggtggagga     2520

acacaggatt gggcttcagc ttctctaggg actggtacat taagagatga agacataaaa     2580

ggtgagaaaa acatggttta tttccaatgt ttccatttct gttaaaagta atgctttcaa     2640

cagaaaaaaa atgcagcaat ataagtgtgt aatttacaaa ataatttcag gatttcttta     2700

atcattaatt tgtggtgtca tctgttaact ggatttacgt ctaagctcat ttgtaaataa     2760

cttcaaatat ccaagccttc cctcaccctt ttcccacctc acctctcctc cttctcctcc     2820

cctacactgg aggacactat gtacatgcat ataatgtcct gccctagagg agtcctgagc     2880

ctacttggga agaaaacacc aactcacagg aaaacagcag aaatcacaca aaacagaata     2940

aaagcaagcg ctgatctgta agtgaagact taagtgctat aggacttcca gctacaaatc     3000

ctgaaaacac ggagtggctg tgataatacg actagccaac atcacacagt aattttgcac     3060

ataaggagaa ctaaatcaaa gaaaacaagg aaaagaaagt tgagcctata atcgtgatac     3120

aggcactaaa atctcaggtg acatttttca atgggggaaa gtcagtcaac ttccgatctc     3180

caaaccatct ttactagcga gcttcccaca atggttctag aaccttcctt cattccaacc     3240

caaccaggat tccaacagac tcataaacac cacagccttt gagaaattaa agggagaacc     3300

caccaaccgg cgccccactc cccaccccaa gtcacctctg gctcaaccaa gatgcgctca     3360

ggccaagaaa gctgccccac cccacaggct ttgcctgtca tttttaacaa gccgactcag     3420

cacatctctc agatgggcca tgcaaggctt ttcgcagctc ctggggcttt gcctcttcat     3480

gagcagacac tccctcttag actaagacct ggagctggaa agtaggtggt aaccgcggta     3540

caaaactcac gctcgtccct gcagaaactg cctaggtcgg cccatggcca cggggcgcca     3600

atttttcaag gaaaagtcaa tgctaataat ggtggcaatc acgggaaatc cattctgagg     3660

ccagatctga cttgtcagga ttaatcatca tttccactta acttcgaact gacctgggta     3720

aaaacgtgag cgcgagggga ccaggctgca cctctgacct ggctcccctc tgcaaaaatc     3780

gcgaagtggg tgcccgaggt ggggcggggg ttgggggaga cctccccggg agtccccacc     3840

cagcctgctc tgcacatctt agtccctcat ccgcttgcgc tgtgcaaatc tgtcttctgt     3900

catttgtatc gcaagacatc aaaatcccca accaaatgca aatactgaga cctcataatc     3960

tgagacaaag tttcacggta tccagaaagc ccccagcagg tgtgcagtgc agagccagcc     4020

ccccagcggt cttccgcaga atcctatcag tttccccctt tcgtgctgtg tgcatcgagc     4080

aggaaggggc ttggcaggtt ttacctgccc tctttccttt ctgaaaagtc tgggcctcct     4140

caccccgaaa ggagtcacct ccttgcagtt ccccagttgc gaaaagagga ggaagttggc     4200

tgggccgggg gccgcggggg gcaccctccg cagatggcgg gacccccctg ccggccatgg     4260

caaaaacgag gcttgtctct cccaccgccc ccaaccttag tccttggcac attgttgaaa     4320

gtaattgaat aaaatcggaa attcgagaag gcgttcgttc ggattggtga gattttgagg     4380

ggagaaagaa gcggggactt cgccggcacc agcggcgccc cctcctcggc caccgttaac     4440

ccccattcca gagggcactg ccccgccacc cagcctaggt ccccctgcga gagcctcgcg     4500

ggcccgcgca gcctccgcga ctcgaacaga tcttcagtcc ttggaggaat gcctgtttct     4560

ctaacaataa aaaattaaag aagcgctcat aaatgccaag tcctctcgca ctatgcggag     4620

tacagaggac aacgaccaca gccatccctg aaccccgccc acggcacagc gccggagccg     4680

gggtctgggg cgccgcttcc tggggggtcc cgactctcag ccgcccccgc ttcacccggg     4740

ccgccaaggg gctgggggag gcggcgctcg gggtaaccgg gggagactca gggcgctggg     4800

ggcacttggg gaactcatgg gggctcaaag gaactaggag atcgggacct cgaaggggac     4860

ttggggggtt cggggctttc gggggcggtc gggggttcgc ggacccggga agctctgagg     4920

acccagaggc cgggcgcgct ccgcccgcgg cgccgccccc tccgtaactt tcccagtctc     4980

cgagggaaga ggcggggtgt ggggtgcggt taaaaggcgc cacggcggga gacaggtgtt     5040

gcggccccgc agcgcccgcg cgctcctctc cccgactcgg agcccctcgg cggcgcccgg     5100

cccaggaccc gcctaggagc gcaggagccc cagcgcagag accccaacgc cgagaccccc     5160

gccccggccc cgccgcgctt cctcccgacg caggtgagcc cgccggcccc ggactgcccg     5220

gccaggaacc tggcgcgggg agggaccgcg agacccagag cggttgcccg gccgcgtggg     5280

tctcggggaa ccggggggct ggaccaacac acgtccttgg gccggggggc gggggccgcc     5340

ttctggagcg ggcgtttctg cggccgagct ccggagctgg aatggggcgg ccggggaagt     5400

ggacgcgatg gcaccgcccg gggtgcgagt ggggccgggc gcgcgcggga ggggaaaaag     5460

gcgcgggcga gccgccagcg cgaggtttgt ggtgtcgccg atgtcccttc ggggtactct     5520

agcgcagccg cctggctact tgacccactg ccaccaaacg ttttaaattc accgaaagct     5580

tagcttcgaa gcaaagctcc gtttcgccgg tgaagcagga agccttcgct gcaggaactg     5640

acctttacct cttggagcgg cttctgcaga aaaatccccg ggcagagatt tgggcggagt     5700

ttgcctagaa ctaacgcgga gccagccgat cccggcctac cccggggcca agatttcagt     5760

ggcttccctt tttcctaaac acttcacgag ggtctgtttc cgggctgtgc tccccgccta     5820

gaaggaaaat ttttaggacc cttgttcgcg aagaggtggt gtgcggctga gacccgcgtc     5880

ctcaggacgg ttccatcagt gcctcgatcc tgccccactg gaggaggaag gcagcccgaa     5940

cagcgctcac ctaactaaca gctgctgaga gctgggttcc gtggccatgc acctgggact     6000

gccttgagaa gcgtggtacg gccgtgtccc catgtgacct tagagtccct ttcgaaactg     6060

ctgtgcacag tcggtcacaa tttcagacac tggtgagaag ggtggaggaa ccctctgggg     6120

acagccaggc aaggtcgacc acccatcacc taagggtgga gaaatttaag gggtgaagag     6180

tcccttttgc cttttctgga tcctggtgat tcacctagtg tcttccctaa ggaactgaac     6240

caactcctcc gctggcctct ggcagccctc caggcggtgc aggatggcgt gggcccggta     6300

ggaagctgca tgtaaccgcc cagggtcggg aggccaggag ggcagctcct cctctgactt     6360

gaatattgaa aacaacttcg tcctgcttct gagcccctct taacccatga ccccctagcc     6420

cattggggag taaatcttaa tttactcctc ttcctgaaaa aggatcttta aaacaggtag     6480

cttcaactca agctttataa aataacaata tagggtttct cggaactgta tttttctcag     6540

ctgatggtaa ctggacaggt ctgtagaagg gtgtatgacc tgggtttggc aggtggaaga     6600

gggcaaagga taaacccctc ctcctgcagc cccatattct tggccaggtg tattgttgta     6660

aaccaggaga gagtttactt cggggagtat cctgttttcc actcagtgag ggccaatgaa     6720

gaatgtctaa ttccataaga tgcttttgtt aaaatcggaa tgttgctgtc ctcggtggtt     6780

ctgctgttgg gacgggactg gcctgagctg tgggtgctgt agcaggacaa ccagctcacc     6840

taagggcctc ccagtctgga ttatcaatgg gtcagtgctg aacctgggct aaaatattgt     6900

tttttccaat gatgttgtct ttcccaagct cagtgaagct aaatgtttca caggcctatg     6960

tcaatctgat gtaactttcg tggccacctc tctcctgtta gcctctgacc aaggtggcac     7020

tggatggttt ctgcctgacc ttggtgcccc gtggcagcga ctgtgggtca tgaaagacat     7080

tcactacgag cctgcttctg gagtccatca gaaaacggga tgcaacttgc ctaaaatgag     7140

gagaggagga tgcttttaag aaaaagaaga aggaggattc actaccagct ctgaagggtg     7200

gaaaagagat gattcatccg gattgtggag agggtggaat cttgtttagg agagcgttgg     7260

ttgtggcagg cagggtgtaa ctatgaatca gtgaagacaa ttcacatcct gggatgaaaa     7320

gaaggccatg ggctcacagg agattatcca ctggcctctc cacatccgct tgcagtaagg     7380

agtgtgggac tctcccaagc ttcagcgctg aactgcaatg cagtgacgtc gcttagctgg     7440

gccagtaacc gagggagttg aattttctgt cattttaaaa taatgtgtct tttaagaaac     7500

actttgaaat taaaaccaca gcccacaatt ataatgcact gttgcagcac ttatcaaaac     7560

agatatgcta actgagccat cagtgccagc ctgacagtga ggccaccaag ccatccacaa     7620

agcctacacg aaagtctgtg ctcacagtgg cttttctcca tgaagagggc attcctaacc     7680

tcttcctttc acgtaggagg aagcaaggtc ctttgtaaaa ttttaactcg gggtgcctca     7740

aatgtaaact taaccactgg taacaacagt ttcactgcta catgccacgt ctgtgaaaat     7800

tcattcaaga cattaaggaa agtggctcag cagagagact agacatctta tcctcacggt     7860

tctcctgtac ttggcctctc agcctttgag caaggttggc ccaagctagt atcggcccca     7920

gtggtacagc caaaacttga gactgcaaat ggatgcagct gttgaacgct gagtaacttc     7980

tgcagagtca ggaagaccca aggaagctct gcagaggatg caggggtacg gtcagaaccc     8040

ctgagtgcct ttcagctaac gaggacttta tgacactccc cagcacagca aatttttatg     8100

atgtgtttaa agattgggtg aattactcag gtgaacaagc tactttttat cagagaacac     8160

ctaaaaacac gttcaagagg gtttgggaac tatacattta atcctatgac aaactaagtt     8220

ggttctgtct tcacctgttt tggtgaggtt gtgtaagagt tggtgtttgc tcaggaagag     8280

atttaagcat gcttgcttac ccagactcag agaagtctcc ctgttctgtc ctagctagtg     8340

attcctgtgt tgtgtgcatt cgtcttttcc agagcaaacc gcccagagta gaagatggat     8400

tggggcacgc tgcagacgat cctggggggt gtgaacaaac actccaccag cattggaaag     8460

atctggctca ccgtcctctt catttttcgc attatgatcc tcgttgtggc tgcaaaggag     8520

gtgtggggag atgagcaggc cgactttgtc tgcaacaccc tgcagccagg ctgcaagaac     8580

gtgtgctacg atcactactt ccccatctcc cacatccggc tatgggccct gcagctgatc     8640

ttcgtgtcca cgccagcgct cctagtggcc atgcacgtgg cctaccggag acatgagaag     8700

aagaggaagt tcatcaaggg ggagataaag agtgaattta aggacatcga ggagatcaaa     8760

acccagaagg tccgcatcga aggctccctg tggtggacct acacaagcag catcttcttc     8820

cgggtcatct tcgaagccgc cttcatgtac gtcttctatg tcatgtacga cggcttctcc     8880

atgcagcggc tggtgaagtg caacgcctgg ccttgtccca acactgtgga ctgctttgtg     8940

tcccggccca cggagaagac tgtcttcaca gtgttcatga ttgcagtgtc tggaatttgc     9000

atcctgctga atgtcactga attgtgttat ttgctaatta gatattgttc tgggaagtca     9060

aaaaagccag tttaacgcat tgcccagttg ttagattaag aaatagacag catgagaggg     9120

atgaggcaac ccgtgctcag ctgtcaaggc tcagtcgcta gcatttccca acacaaagat     9180

tctgacctta aatgcaacca tttgaaaccc ctgtaggcct caggtgaaac tccagatgcc     9240

acaatggagc tctgctcccc taaagcctca aaacaaaggc ctaattctat gcctgtctta     9300

attttctttc acttaagtta gttccactga gaccccaggc tgttaggggt tattggtgta     9360

aggtactttc atattttaaa cagaggatat cggcatttgt ttctttctct gaggacaaga     9420

gaaaaaagcc aggttccaca gaggacacag agaaggtttg ggtgtcctcc tggggttctt     9480

tttgccaact ttccccacgt taaaggtgaa cattggttct ttcatttgct ttggaagttt     9540

taatctctaa cagtggacaa agttaccagt gccttaaact ctgttacact ttttggaagt     9600

gaaaactttg tagtatgata ggttattttg atgtaaagat gttctggata ccattatatg     9660

ttccccctgt ttcagaggct cagattgtaa tatgtaaatg gtatgtcatt cgctactatg     9720

atttaatttg aaatatggtc ttttggttat gaatactttg cagcacagct gagaggctgt     9780

ctgttgtatt cattgtggtc atagcaccta acaacattgt agcctcaatc gagtgagaca     9840

gactagaagt tcctagtgat ggcttatgat agcaaatggc ctcatgtcaa atatttagat     9900

gtaattttgt gtaagaaata cagactggat gtaccaccaa ctactacctg taatgacagg     9960

cctgtccaac acatctccct tttccatgac tgtggtagcc agcatcggaa agaacgctga    10020

tttaaagagg tcgcttggga attttattga cacagtacca tttaatgggg aggacaaaat    10080

ggggcagggg agggagaagt ttctgtcgtt aaaaacagat ttggaaagac tggactctaa    10140

agtctgttga ttaaagatga gctttgtcta cttcaaaagt ttgtttgctt accccttcag    10200

cctccaattt tttaagtgaa aatatagcta ataacatgtg aaaagaatag aagctaaggt    10260

ttagataaat attgagcaga tctataggaa gattgaacct gaatattgcc attatgcttg    10320

acatggtttc caaaaaatgg tactccacat atttcagtga gggtaagtat tttcctgttg    10380

tcaagaatag cattgtaaaa gcattttgta ataataaaga atagctttaa tgatatgctt    10440

gtaactaaaa taattttgta atgtatcaaa tacatttaaa acattaaaat ataatctcta    10500

taataattta aaatctaata tggttttaat agaacagcaa attttaattt catctatcac    10560

tttttatata aatacattaa tgttttatat ttcataacac caatgggtaa gttgccagag    10620

tgtctgaccc cattctgccc cagttacaga aaagcttctg tcaccagaaa gtttggtggg    10680

gaaggaaggg aggaagatga tttctaccta accccgtgcc cacctctacc aggtttttga    10740

ggcatatcag tctatggaca atgtggtgtt tggtctggaa acgtaccttg gtgaatgctg    10800

agttggctgg acatgacccg tttagctcct ggatgaatcc cagaagtgga ccttcaaaat    10860

gttactcata gcatgacctt ggctcactgc aacctctgcc tcccaggctc aagcgatcct    10920

cccacctcag cgtcccaagt agctgggacc actggagtgt gccaccacac tccactaatt    10980

ttttcatttt ttgtagaaac gaggtcccac tatattgccc agtctggtct cgaactcctg    11040

ggctgaaggg atccccctgc ctcagtctcc taaagtgcaa ggattacagg catgggccac    11100

cgcacctggc ctgaaactgc tttttattcc tcagtgccca cttccatggg aaataagcct    11160

gccaggtcag cctgtcccca tgggagtgac tgcctgctac ccccacaggc ttgcccggcc    11220

ctcgtgagcc tctcccagag acaccaccaa cagttctgtt ctttcatggt acaagatttc    11280

catccaagga tttcaaagca tttcacacat caataattag aagtattttc atagaggacc    11340

atacactttt aaaatggatt tcaaagaaca aaaaccagtc aactatcacc caggtaatag    11400

aaaatgggaa atggtttcta cctgacttcc aaaatgctct gcacatagac tgtgaaaata    11460

ggatttttta agctgggtgc agaggcttat acctataatc ccaacacttt gggaggctga    11520

gacgagagga tcacttgagc ccaggagttc aaaaccagcc tgggcaatat agggagacat    11580

tgtttctata aaaaataaaa atgttagcca ggcaggcgtg gtaacatgtg cctgtagtct    11640

cagctactca ggaggctgag gtgggaagat tgcttgaacc tgggaggtcc atgctgcagt    11700

gagctgagat tgtgccactg cactccagcc taggcgacag caagatcctg tcccaaacaa    11760

caacaacatc aaaaaacaca gaacttttaa aataagtaca ttcacttcta caagctatgt    11820

agattattac tctcaagcta ttaaaagacc aagccaaaat aattatgggc tactctcgac    11880

cacttgtagg aatggataga gaggtctggt cacatgcctg gaaattagag cttgagctct    11940

gaaaatgata atcctgacta tatctcaaag catcagtctg cactttgtat ggagcaagaa    12000

aaagccttgt ggaagcggcc tcccacccag ccgagccctc ggcgtggaca agctctgctt    12060

tttatgagca gtgggtgcag cctcgctgct ccctcctcct gtcaaaagac agtcacagct    12120

ggggtgagca gatcgggccc acttgggagg ccccaaggaa tatgctgcag gggtcgggcc    12180

tgagccaccc ccacgggttg gtctttgaca actagagagc agctgagagg tgggtaaaag    12240

ctcactcact taccctgacc tcagtgtcct catcttaaaa tgggtttcct gaatctttcc    12300

ccggcttagt ggcaatgaaa taagataatt tatgtaaacg ttctccacat agtaaagcac    12360

taagtaacat atgactgtca tctgttttcc actagacaga tcccaacctg gaagagtgac    12420

agatggtatt tcagatacaa gtgactcaag caaagcttga taaactgggg gctggaaaaa    12480

aatgcacatt tacacaaagc ctggagtaac tgc                                 12513


<210>  123
<211>  678
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary codon optimized Human GJB2 DNA sequence

<400>  123
atggactggg gcaccctgca gactatcctg gggggcgtca ataagcattc aactagcatc       60

ggaaagattt ggctgactgt cctgtttatc tttcggatca tgatcctggt ggtggcagca      120

aaggaagtgt ggggcgacga gcaggccgat ttcgtgtgca acacactgca gccaggctgc      180

aagaacgtgt gctacgacca ctattttccc atctctcaca tcaggctgtg ggccctgcag      240

ctgatcttcg tgagcacccc tgccctgctg gtggcaatgc acgtggccta tcggagacac      300

gagaagaagc gcaagtttat caagggcgag atcaagagcg agttcaagga tatcgaggag      360

atcaagacac agaaggtgag gatcgagggc tccctgtggt ggacctacac aagctccatc      420

ttctttcgcg tgatcttcga ggccgccttt atgtacgtgt tctatgtgat gtacgacggc      480

ttttctatgc agcggctggt gaagtgcaac gcctggccct gtcctaatac agtggattgt      540

ttcgtgtcca gacccaccga gaagacagtg ttcaccgtgt ttatgatcgc cgtgtctggc      600

atctgcatcc tgctgaacgt gaccgagctg tgctatctgc tgatccggta ctgtagtgga      660

aagagcaaaa aacccgtg                                                    678


<210>  124
<211>  678
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary codon optimized Human GJB2 DNA sequence

<400>  124
atggactggg gaacattgca aactattttg ggaggagtca acaagcattc aactagcatc       60

gggaagatct ggctgaccgt gctgttcatc tttcgcatca tgattctcgt ggtggccgct      120

aaggaagtct ggggcgatga acaggccgac ttcgtgtgta acacgctgca gcccggttgc      180

aaaaacgtct gctacgatca ctacttcccc atctcacaca ttagactgtg ggcgctgcag      240

ctgattttcg tgtccacccc ggcacttctt gtggcgatgc acgtggccta ccggcggcac      300

gagaagaaaa ggaagttcat taagggcgaa atcaagtccg agttcaagga catcgaagaa      360

atcaagaccc agaaggtccg cattgagggc tccctctggt ggacctacac ctcgtccatc      420

ttcttccggg tcatattcga ggccgccttt atgtacgtgt tttacgtgat gtacgacggt      480

ttcagcatgc aaagactcgt caagtgcaac gcttggcctt gccccaatac cgtggattgc      540

ttcgtgtccc gcccgaccga gaaaactgtg ttcactgtgt tcatgatcgc cgtgtccggc      600

atctgcatcc tgctgaacgt gaccgagctg tgctatctcc tgatccggta ctgtagcgga      660

aagtcgaaga agcctgtg                                                    678


<210>  125
<211>  678
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary codon optimized Human GJB2 DNA sequence

<400>  125
atggattggg ggacgctcca gactatactt ggcggggtaa acaaacattc cacctcaatt       60

ggcaaaatct ggctcacagt cctcttcatc ttcagaataa tgatactcgt ggttgccgct      120

aaagaagttt ggggtgacga gcaagccgat ttcgtctgta acaccctcca accaggttgc      180

aaaaatgtct gttacgatca ctactttcct attagccata ttagactctg ggccctgcaa      240

cttatcttcg tttccactcc tgctctgctc gtcgctatgc acgttgccta tcgccgccat      300

gaaaaaaaac ggaaattcat taagggagag attaagagtg aattcaagga tattgaagag      360

attaaaacgc aaaaagttag aattgaggga tcactgtggt ggacttatac cagtagcatc      420

ttttttaggg tcattttcga agctgctttc atgtatgttt tctatgtaat gtacgacggt      480

ttctccatgc aacgcttggt taaatgtaac gcctggccat gccctaatac ggttgattgc      540

tttgtctccc gccctactga aaagacagtg tttaccgttt tcatgatcgc cgtaagtgga      600

atttgtatcc ttcttaacgt gaccgagttg tgctatctcc ttattcgcta ctgttcagga      660

aaaagtaaaa aaccagta                                                    678


<210>  126
<211>  681
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary codon optimized Human GJB2 DNA sequence

<400>  126
atggactggg gcacgctgca gactatcctg gggggtgtca acaagcattc aactagcatc       60

ggaaagatct ggctgaccgt cctgttcatc tttcgcatca tgatcctcgt ggtggccgct      120

aaggaagtgt ggggcgacga gcaggccgat ttcgtgtgta acaccctgca gccaggttgc      180

aaaaacgtct gctacgatca ctactttccc atctcccaca ttagactgtg ggccctgcag      240

ctgatcttcg tgtccacccc tgcgctgcta gtggccatgc acgtggccta tcggcgacac      300

gagaagaaac ggaagttcat taagggcgag atcaagagcg agttcaagga tatcgaagag      360

atcaagaccc agaaggtccg cattgagggc tccctgtggt ggacctacac cagctccatc      420

ttctttcggg tcatcttcga ggccgccttt atgtacgtgt tctatgtgat gtacgacggt      480

ttctccatgc aacggctggt gaagtgcaac gcctggcctt gccctaatac tgtggattgc      540

ttcgtgtccc gccccaccga gaagacagtg ttcaccgtgt tcatgatcgc cgtgtctggc      600

atctgcatcc tgctgaacgt gaccgagctg tgctatctcc tgatccggta ctgtagtgga      660

aagtcaaaaa aaccagtgta a                                                681


<210>  127
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary Human Connexin 26 Protein Sequence

<400>  127

Met Asp Trp Gly Thr Leu Gln Thr Ile Leu Gly Gly Val Asn Lys His 
1               5                   10                  15      


Ser Thr Ser Ile Gly Lys Ile Trp Leu Thr Val Leu Phe Ile Phe Arg 
            20                  25                  30          


Ile Met Ile Leu Val Val Ala Ala Lys Glu Val Trp Gly Asp Glu Gln 
        35                  40                  45              


Ala Asp Phe Val Cys Asn Thr Leu Gln Pro Gly Cys Lys Asn Val Cys 
    50                  55                  60                  


Tyr Asp His Tyr Phe Pro Ile Ser His Ile Arg Leu Trp Ala Leu Gln 
65                  70                  75                  80  


Leu Ile Phe Val Ser Thr Pro Ala Leu Leu Val Ala Met His Val Ala 
                85                  90                  95      


Tyr Arg Arg His Glu Lys Lys Arg Lys Phe Ile Lys Gly Glu Ile Lys 
            100                 105                 110         


Ser Glu Phe Lys Asp Ile Glu Glu Ile Lys Thr Gln Lys Val Arg Ile 
        115                 120                 125             


Glu Gly Ser Leu Trp Trp Thr Tyr Thr Ser Ser Ile Phe Phe Arg Val 
    130                 135                 140                 


Ile Phe Glu Ala Ala Phe Met Tyr Val Phe Tyr Val Met Tyr Asp Gly 
145                 150                 155                 160 


Phe Ser Met Gln Arg Leu Val Lys Cys Asn Ala Trp Pro Cys Pro Asn 
                165                 170                 175     


Thr Val Asp Cys Phe Val Ser Arg Pro Thr Glu Lys Thr Val Phe Thr 
            180                 185                 190         


Val Phe Met Ile Ala Val Ser Gly Ile Cys Ile Leu Leu Asn Val Thr 
        195                 200                 205             


Glu Leu Cys Tyr Leu Leu Ile Arg Tyr Cys Ser Gly Lys Ser Lys Lys 
    210                 215                 220                 


Pro Val 
225     


<210>  128
<211>  1044
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary Regulatory sequence C3

<400>  128
cttcttctgg agtcttttct ggaataattc tgggagtggg ctcagcctgc gggagagtaa       60

catttttata acttgataga tgtagctgag atgcctccca gaggggagac ccgcctctcc      120

tccggcagct gtgcacgtag gcttgttccc agcagcctgg ccagggtggt ccacctggtg      180

tttctcatct tctttccccg gagcgctgac tcctgcgcgt cctcttggaa gactcttgac      240

aggacgggtg ttttatgggt gtgattcagt gtcctcttgc atcagttcaa tgtggtggtg      300

ttcaatcaac ccttgtagcg ttagcaaaat ttgctcaagt cattccgcag gaatgtctgt      360

gtcttgcttc caagaaagct tgtaagtgcc ggcaacaggc caagcagctc acaaacctga      420

ccacaagcct gtgagtaatt gtggggcagc acttagcagt cttttatttt cgacttatta      480

aagtctcatc ttggcctcac cttctccctg gaaggtggcg tgggtgggaa ccactgggtc      540

agatcttttt cacccttgcc gtggagccag tttcctgttg catgtggggg aagcaacatg      600

tggtgaagag tatagaaaac gaaaacatgt gggtacagta tgtataagtg gagggaacaa      660

actcataatt ccaactagtt tctcatgaga gactcatgaa tcattgtggt agttctcaat      720

ataaacttaa tctaggccgg atgtggtggc tcacacctgt aatctcagca ctctgggtgg      780

atcacttgag gtcaggagtt tgagaccagt ctgaccaaca tggagaaacc ccatcgctac      840

taaaaataca aaattatcca gatgtggtgg ctcacacctg taatcccagc actttgggag      900

gctgaggcgg gtggatcact tgaggtcagg agtttgagac cagcctgacc aacatggaga      960

aactgtgtct ctactaaaaa tacaaaatta gctgggcgtg gtgacgcatg cctgtaatcc     1020

cagctatttg gaggccgaag cagg                                            1044


<210>  129
<211>  1044
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary Regulatory sequence D7

<400>  129
cttcttctgg agtcttttct ggaataattc tgggagtggg ctcagcctgc gggagagtaa       60

catttttata acttgataga tgtagctgag atgcctccca gaggggagac ccgcctctcc      120

tccggcagct gtgcacgtag gcttgttccc agcagcctgg ccagggtggt ccacctggtg      180

tttctcatct tctttccccg gagcgctgac tcctgcgcgt cctcttggaa gactcttgac      240

aggacgggtg ttttatgggt gtgattcagt gtcctcttgc atcagttcaa tgtggtggtg      300

ttcaatcaac ccttgtagcg ttagcaaaat ttgctcaagt cattccgcag gaatgtctgt      360

gtcttgcttc caagaaagct tgtaagtgcc ggcaacaggc caagcagctc acaaacctga      420

ccacaagcct gtgagtaatt gtggggcagc acttagcagt cttttatttt cgacttatta      480

aagtctcatc ttggcctcac cttctccctg gaaggtggcg tgggtgggaa ccactgggtc      540

agatcttttt cacccttgcc gtggagccag tttcctgttg catgtggggg aagcaacatg      600

tggtgaagag tatagaaaac gaaaacatgt gggtacagta tgtataagtg gagggaacaa      660

actcataatt ccaactagtt tctcatgaga gactcatgaa tcattgtggt agttctcaat      720

ataaacttaa tctaggccgg atgtggtggc tcacacctgt aatctcagca ctctgggtgg      780

atcacttgag gtcaggagtt tgagaccagt ctgaccaaca tggagaaacc ccatcgctac      840

taaaaataca aaattatcca gatgtggtgg ctcacacctg taatcccagc actttgggag      900

gctgaggcgg gtggatcact tgaggtcagg agtttgagac cagcctgacc aacatggaga      960

aactgtgtct ctactaaaaa tacaaaatta gctgggcgtg gtgacgcatg cctgtaatcc     1020

cagctatttg gaggccgaag cagg                                            1044


