                         SEQUENCE LISTING

<110>  University of Mayrland, College Park
 
<120>  TICK MOUTHPART ANTIGENS AS EFFECTIVE ANTI-TICK VACCINES

<130>  070919.00110

<150>  63/201,846
<151>  2021-05-14

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  240
<212>  PRT
<213>  Ixodes scapularis

<400>  1

Thr Ser Gln Val Lys Tyr Arg Leu Asp Gly Thr Pro Glu His Tyr Val 
1               5                   10                  15      


Ile Asn His Ala Cys Ala Thr Ser Glu Asn Val Phe Arg Pro Phe Gly 
            20                  25                  30          


Gln Gly Lys Thr Phe Val Ala Gln Leu Asn Arg Thr Leu Asp Leu Glu 
        35                  40                  45              


Glu Val His Asp Ala Asn Thr Asp Thr Gln Leu Pro Glu Asp Leu Glu 
    50                  55                  60                  


Lys Val His His Ile Ala Gln Thr Phe Pro Glu Ser Asp Glu Val Glu 
65                  70                  75                  80  


Ser Leu Glu Glu Leu Lys His Val Asn Arg Tyr Val Thr Thr Phe Asp 
                85                  90                  95      


Leu Ser Thr Asp Lys Asp Lys Phe Ile Ser Gly Leu Asn His Leu Ala 
            100                 105                 110         


Ala Leu Glu Tyr Glu Asp Ser Asp Ile Lys Asp Val His Ser Lys Glu 
        115                 120                 125             


Ser Gly Gly Leu Asn Phe Leu Ile Leu Phe Gly Ser Leu Ala Ser Met 
    130                 135                 140                 


Pro Phe Glu Asp Ile Ala His Val Tyr Glu Gln Ala Val Ala Asn Ala 
145                 150                 155                 160 


Pro Glu Ala Ser Lys Ser Gln Val Arg Lys Val Phe Leu Asp Leu Leu 
                165                 170                 175     


Ser Ala Val Gly Asn Asn Pro His Ala Ala Phe Gly Leu Gln Leu Val 
            180                 185                 190         


Lys Glu Asp Lys Leu Thr Asp Glu Glu Ala Glu His Phe Leu Ala Lys 
        195                 200                 205             


Leu Ala Leu Asn Leu Lys Glu Asn Ser Pro Ala Leu Leu Thr Glu Leu 
    210                 215                 220                 


Ala Glu Val Cys Glu His Val Lys Pro Lys Arg Pro Val Trp Val Asn 
225                 230                 235                 240 


<210>  2
<211>  720
<212>  DNA
<213>  Ixodes scapularis

<400>  2
acctctcagg tcaagtacag actcgacgga actccagaac actacgtcat caaccacgcc       60

tgcgccacct cagagaatgt cttcaggccc ttcggtcaag ggaaaacctt cgttgcccag      120

ctcaaccgta ccttggattt ggaggaggtg cacgacgcca acaccgacac tcagcttccg      180

gaggacctgg agaaggtgca ccacatcgcg cagacattcc ccgagtctga tgaggtggaa      240

agcctggagg aactgaagca cgtcaaccgc tacgtgacca cctttgatct ctcgaccgac      300

aaagacaagt tcatctctgg tctcaaccac cttgctgcat tggagtacga agattccgac      360

atcaaggacg ttcacagcaa ggaaagcggt ggactaaact tcctgatttt gttcggctcg      420

cttgcctcca tgccctttga agatatcgcc cacgtgtacg agcaagccgt tgccaatgca      480

ccggaagcaa gcaagagtca agtcagaaag gtgttcctgg acctgctctc agctgtcgga      540

aacaaccctc acgcagcgtt cggtctgcaa ctggtcaagg aagacaaact cactgacgaa      600

gaggctgagc acttcctcgc caagctggcg ctgaacctta aggagaacag ccccgctctt      660

ctgaccgaac ttgccgaggt gtgtgagcac gtgaagccta agcgaccagt atgggtcaac      720


<210>  3
<211>  1329
<212>  PRT
<213>  Ixodes scapularis

<400>  3

Met Arg Val Pro Tyr Val Leu Pro Val Leu Phe Leu Ala Ala Ala Ser 
1               5                   10                  15      


Ala Phe Glu Val Gly Lys Asp Tyr Val Tyr His Tyr Asn Gly Lys Met 
            20                  25                  30          


Gln Val Tyr Asn Pro Glu Gln Pro Leu Gln Ser Ser Gly Phe Ala Phe 
        35                  40                  45              


Arg Ser Lys Val Val Ala Gln Pro Arg Pro Asp His Thr His Phe Lys 
    50                  55                  60                  


Ile Ile Asp Phe Glu Val Asp Ser Phe Asn Gly Asp His Val His Val 
65                  70                  75                  80  


Gly Glu His Glu Phe Asn Tyr His Ser Thr Glu Ala Leu Lys Gln Phe 
                85                  90                  95      


Ile Glu Arg Pro Phe Ala Gly Lys Phe Ser Glu Gly Lys Leu Glu Glu 
            100                 105                 110         


Ala Glu Leu Ser Lys Ser Glu Pro Lys Trp Ala Arg Asn Leu Lys Lys 
        115                 120                 125             


Gly Val Leu Ser Ile Phe Gln Leu Asp Leu Val Lys Gly Arg His Asp 
    130                 135                 140                 


His Pro His Ala Lys Gln Phe His Val Arg Glu Glu Gly Leu His Gly 
145                 150                 155                 160 


Asn Cys Asp Thr Leu Tyr Val Val Ala Glu Glu Glu Gly His Leu Lys 
                165                 170                 175     


Val Thr Lys Ile Lys Asn Leu Glu Lys Cys Asp Lys Glu His Tyr Ala 
            180                 185                 190         


Val Tyr Gly Arg Ile Lys Gly His Glu Cys Val Asp Cys Glu Ala Gln 
        195                 200                 205             


Glu Thr His Pro Phe Val Ala Thr Ser Gln Val Lys Tyr Arg Leu Asp 
    210                 215                 220                 


Gly Thr Pro Glu His Tyr Val Ile Asn His Ala Cys Ala Thr Ser Glu 
225                 230                 235                 240 


Asn Val Phe Arg Pro Phe Gly Gln Gly Lys Thr Phe Val Ala Gln Leu 
                245                 250                 255     


Asn Arg Thr Leu Asp Leu Glu Glu Val His Asp Ala Asn Thr Asp Thr 
            260                 265                 270         


Gln Leu Pro Glu Asp Leu Glu Lys Val His His Ile Ala Gln Thr Phe 
        275                 280                 285             


Pro Glu Ser Asp Glu Val Glu Ser Leu Glu Glu Leu Lys His Val Asn 
    290                 295                 300                 


Arg Tyr Val Thr Thr Phe Asp Leu Ser Thr Asp Lys Asp Lys Phe Ile 
305                 310                 315                 320 


Ser Gly Leu Asn His Leu Ala Ala Leu Glu Tyr Glu Asp Ser Asp Ile 
                325                 330                 335     


Lys Asp Val His Ser Lys Glu Ser Gly Gly Leu Asn Phe Leu Ile Leu 
            340                 345                 350         


Phe Gly Ser Leu Ala Ser Met Pro Phe Glu Asp Ile Ala His Val Tyr 
        355                 360                 365             


Glu Gln Ala Val Ala Asn Ala Pro Glu Ala Ser Lys Ser Gln Val Arg 
    370                 375                 380                 


Lys Val Phe Leu Asp Leu Leu Ser Ala Val Gly Asn Asn Pro His Ala 
385                 390                 395                 400 


Ala Phe Gly Leu Gln Leu Val Lys Glu Asp Lys Leu Thr Asp Glu Glu 
                405                 410                 415     


Ala Glu His Phe Leu Ala Lys Leu Ala Leu Asn Leu Lys Glu Asn Ser 
            420                 425                 430         


Pro Ala Leu Leu Thr Glu Leu Ala Glu Val Cys Glu His Val Lys Pro 
        435                 440                 445             


Lys Arg Pro Val Trp Val Asn Cys Gln Leu Ala Leu Ser Thr Leu Ala 
    450                 455                 460                 


Gly Gln Glu Gly Cys Val Arg Ala Lys Thr Asp Lys Glu Gln Asp Glu 
465                 470                 475                 480 


Gly Phe Cys Lys Pro Ser Ile Val Ser His Phe Phe Asn Tyr Glu Ile 
                485                 490                 495     


Lys Pro Glu Asp Lys Lys Asp Gln Pro Glu Tyr Lys Arg Thr Val Tyr 
            500                 505                 510         


Met Lys Ala Ala Gly Asn Leu Ala Thr Arg Gly Ala Val His Tyr Leu 
        515                 520                 525             


Glu Arg Tyr Val Ser Asp Thr Asn Gln Pro Glu Tyr Arg Arg Ser Ala 
    530                 535                 540                 


Ala Leu Trp Ala Met Val Arg Ala Ala Pro His His His Glu Leu Val 
545                 550                 555                 560 


Arg Asp Val Ala Leu Pro Leu Tyr Lys Asn Lys Ser Glu Thr Ala Tyr 
                565                 570                 575     


Leu Arg Ile Gly Ala Phe Val Asn Val Leu Met Thr Lys Pro Asp Leu 
            580                 585                 590         


Tyr Leu Leu Lys Tyr Ile Gly His Asn Ile Ile Asp Asp Pro Ser Asp 
        595                 600                 605             


Gln Leu Ala Ser Tyr Val Thr Ser Ala Phe Arg Ser Leu Val Lys Ser 
    610                 615                 620                 


Lys Tyr Pro Cys His Gln Glu Leu Ala Gln His Leu Arg Tyr Val Val 
625                 630                 635                 640 


Pro Met Trp Asn Asp Val Ser Arg Phe Ala Lys Pro Leu Asp His Thr 
                645                 650                 655     


Lys Ser Gln Val Ile Leu Ser Ser Gly Tyr Asp Pro Lys Tyr Asp Tyr 
            660                 665                 670         


Gly Gly Ser Ser Val Phe Ala Gln Val Arg Ala Asp Asp Ser Tyr Leu 
        675                 680                 685             


Pro Arg Glu Val Tyr Phe Ser Ala Lys Asp Tyr Phe His Gly Arg Ser 
    690                 695                 700                 


Phe Glu Ser Val Ser Leu Lys Phe Glu Ser Trp Gly Leu Asp Lys Leu 
705                 710                 715                 720 


Leu Asn His Val Val Gly Pro Gln Pro Gly Ser Thr Lys Asn Leu Trp 
                725                 730                 735     


Asn Val Phe Gly Arg Arg Arg Phe Thr Arg Asp Ala Ser Ala Lys Asp 
            740                 745                 750         


Leu Gln Glu Val Glu Ala Ala Leu Pro Ile Thr Asp Arg Asp Tyr Asp 
        755                 760                 765             


His Val Tyr Gly Arg Leu Ser Leu Asp Leu Tyr Gly His Ala Phe Asp 
    770                 775                 780                 


Thr Trp Glu Phe Asp Glu Ser Ile Leu Gln Glu Leu Ser Lys Gly Glu 
785                 790                 795                 800 


Gly Glu Glu Ala Pro Gly Asp Lys Leu Lys Asn Leu Leu Gly Glu Ser 
                805                 810                 815     


Lys Arg Lys Lys Ser Phe Ile Leu Ser Lys Asp Ile Cys Val Met Val 
            820                 825                 830         


Pro Ser Glu Leu Gly Val Pro Val Phe Tyr His Ile Leu Gln Val Glu 
        835                 840                 845             


Tyr Met Tyr Ile Asn Pro Lys Lys Phe Ala Phe Asp Gln Thr Gln Asp 
    850                 855                 860                 


Ala Lys Phe Ala Val Asp Leu Glu Arg His Tyr Val His Glu Ser Arg 
865                 870                 875                 880 


Gly Tyr Ser Met Phe Gly Val Ala Leu Thr Phe Asn Lys Thr Ser Met 
                885                 890                 895     


Gly Thr Gly Ser Asp Ser Gln Thr Ile Met Asn Leu Pro Ile Asp Leu 
            900                 905                 910         


Lys Ile Thr Leu Asp Pro Ile His Lys Lys Leu Ser Met Lys Arg Pro 
        915                 920                 925             


Leu Ser Leu Pro Trp Asn Val Leu Asn His His Phe Arg Pro Phe Thr 
    930                 935                 940                 


Phe Val Met Ser Tyr Asp Met His Lys Asp Ala Thr Thr Thr Glu Thr 
945                 950                 955                 960 


Met Met Thr Gln Ala Met His Pro Leu Tyr Asn Lys Glu Glu Leu Thr 
                965                 970                 975     


Glu Phe Asp Arg Asn Tyr Phe Gly Glu Val Leu Gly Tyr Gly Leu Asn 
            980                 985                 990         


Val Lys Gly Ser Leu Leu Ser Lys  Gly Leu Lys Lys Gly  Leu His Asp 
        995                 1000                 1005             


Tyr Trp  Tyr Glu Ser Asp Asp  Arg Gln Lys Phe Tyr  Tyr Ala Thr 
    1010                 1015                 1020             


Leu Asn  Pro Glu Trp His Pro  Arg Glu Leu Gln Phe  Thr Val Val 
    1025                 1030                 1035             


Pro Ala  Ala Gln Asp Ala Thr  Thr Glu Val Glu Val  Asp Leu Gly 
    1040                 1045                 1050             


Tyr Lys  Phe Leu Glu Pro Asp  Asp Pro Arg Glu Ser  His Phe Glu 
    1055                 1060                 1065             


Ala His  Asp Asn Val Gly Asp  Asp Ala Glu Val Pro  Ser Thr His 
    1070                 1075                 1080             


Val Leu  Asn Leu Asp Tyr Thr  Leu Lys Gly Thr Lys  Glu Arg Lys 
    1085                 1090                 1095             


Val Ser  Ala Glu Leu Arg Tyr  Ser Phe Thr Lys Asp  Leu Leu Lys 
    1100                 1105                 1110             


His Lys  Val Gln Leu Phe Tyr  Asp Arg Thr Pro Phe  His Pro Lys 
    1115                 1120                 1125             


Glu Gln  Asp His Thr Lys Val  Glu Val Asp Leu Gly  Tyr Lys Phe 
    1130                 1135                 1140             


Leu Glu  Pro Asp Asp Pro Arg  Glu Ser His Phe Glu  Ala His Asp 
    1145                 1150                 1155             


Asn Val  Gly Asp Asp Ala Glu  Val Pro Ser Thr His  Val Leu Asn 
    1160                 1165                 1170             


Leu Asp  Tyr Ala Leu Lys Gly  Thr Lys Glu Arg Lys  Val Ser Ala 
    1175                 1180                 1185             


Glu Leu  Arg Tyr Ser Phe Thr  Lys Asp Leu Leu Lys  His Lys Val 
    1190                 1195                 1200             


Gln Leu  Phe Tyr Asp Arg Thr  Pro Phe His Pro Lys  Glu Gln Asp 
    1205                 1210                 1215             


His Thr  Lys Ile Thr Phe Lys  Gly Lys Tyr Thr His  Thr Asp Asp 
    1220                 1225                 1230             


Glu Glu  Lys Gln Ile Arg Glu  Asn Ala Glu Gly Lys  Pro Leu Gly 
    1235                 1240                 1245             


Ile Asn  Arg Met Lys Lys Tyr  Thr Leu Arg Arg Pro  Tyr Lys Lys 
    1250                 1255                 1260             


Cys Thr  Glu His Gln Lys Arg  Gly Val Pro Leu Asn  Phe Glu Cys 
    1265                 1270                 1275             


Met Lys  Tyr Leu Tyr Tyr Thr  Ser Arg Leu Gly Lys  Leu Thr Thr 
    1280                 1285                 1290             


Asp Val  Glu Tyr Lys Asn Leu  Lys Pro Val Ser Val  Glu Gly Leu 
    1295                 1300                 1305             


His Pro  Val Asn Gln Gly Arg  Ala Pro Ala Ser Phe  Arg Arg Phe 
    1310                 1315                 1320             


Arg Thr  Gly Ala Pro Arg 
    1325                 


<210>  4
<211>  1555
<212>  PRT
<213>  Ixodes scapularis

<400>  4

Met Arg Val Pro Tyr Val Leu Pro Val Leu Phe Leu Ala Ala Ala Ser 
1               5                   10                  15      


Ala Phe Glu Val Gly Lys Asp Tyr Val Tyr His Tyr Asn Gly Lys Leu 
            20                  25                  30          


Gln Val Tyr Asn Pro Glu Gln Pro Leu Gln Ser Ser Gly Phe Ala Phe 
        35                  40                  45              


Gln Ser Lys Val Val Ala Gln Pro Arg Pro Asp His Thr His Phe Lys 
    50                  55                  60                  


Ile Ile Asp Phe Glu Val Asp Thr Phe Asn Gly Glu His Val His Leu 
65                  70                  75                  80  


Ser Asp His Gln Phe His Tyr His Ser Thr Asp Ala Leu Lys Gln Phe 
                85                  90                  95      


Ile Glu Arg Pro Phe Ala Gly Lys Phe Ser Glu Gly Lys Leu Glu Ala 
            100                 105                 110         


Ala Glu Leu Gly Lys Ser Glu Pro Met Trp Ser Gln Asn Ile Lys Lys 
        115                 120                 125             


Gly Val Leu Ser Val Phe Gln Leu Asp Leu Val Lys Gly Arg His Asp 
    130                 135                 140                 


Asp Pro His Ala Lys Gln Phe Tyr Val Lys Glu Asp Gly Leu His Gly 
145                 150                 155                 160 


Asn Cys Asp Thr Leu Tyr Val Val Ala Glu Lys Glu Gly His Leu Glu 
                165                 170                 175     


Val Thr Lys Ile Lys Asn Leu Glu Lys Cys Asp Lys Asp His Phe Ala 
            180                 185                 190         


Ile Tyr Gly Arg Ile Lys Ala His Glu Cys Val Asp Cys Glu Ala Gln 
        195                 200                 205             


Glu Ser His Pro Leu Val Ala Thr Ala Gln Val Lys Tyr Arg Leu Asp 
    210                 215                 220                 


Gly Thr Pro Glu His Tyr Val Ile Asp His Ala Cys Ala Thr Ser Glu 
225                 230                 235                 240 


Thr Val Leu Arg Pro Tyr Gly Lys Gly Lys Thr Phe Val Val Gln Leu 
                245                 250                 255     


Asn Arg Thr Leu Asp Leu Glu Glu Val His Asp Ala Asn Thr Asp Thr 
            260                 265                 270         


Gln Leu Pro Glu Asp Leu Glu Arg Val Asp His Leu Ser Gln Thr Leu 
        275                 280                 285             


Pro Val Gly Asp His Val Glu Thr Leu Gln Asp Leu Lys Lys Val Asn 
    290                 295                 300                 


His Phe Val Asp Tyr Phe Gln Leu Thr Asn Asn Lys Glu Lys Phe Val 
305                 310                 315                 320 


Ala Gly Leu Asn His Leu Ala Ala Leu Glu Tyr Glu Asp Asp Asp Val 
                325                 330                 335     


Lys Asp Val His Gly Lys Glu Ser Gly Gly Leu Gln Phe Leu Val Leu 
            340                 345                 350         


Phe Asn Ala Leu Ser Thr Leu His Phe Glu Asp Val Val Gln Val Tyr 
        355                 360                 365             


Glu Gln Ala Val Ala Ser Ala Pro Glu Ala Ser Gln Ser His Val Lys 
    370                 375                 380                 


Arg Leu Phe Leu Asp Leu Leu Ser Ala Ala Gly Thr Asn Pro Gln Val 
385                 390                 395                 400 


Ala Phe Gly Leu Gln Leu Val Lys Glu Asp Lys Leu Ser Asp Asp Glu 
                405                 410                 415     


Ala Glu His Phe Phe Thr Lys Leu Ala Leu Asn Leu Lys Glu Asn Ser 
            420                 425                 430         


Pro Ala Leu Leu Thr Glu Leu Ala Glu Val Cys Glu His Val Lys Pro 
        435                 440                 445             


Lys Arg Gln Val Trp Val Asn Cys Gln Leu Ala Leu Ser Ile Leu Ala 
    450                 455                 460                 


Gly Gln Glu Gly Cys Val Arg Ala Lys Thr Asp Lys Glu His Asp Glu 
465                 470                 475                 480 


Gly Phe Cys Lys Pro Ser Leu Val Ser His Phe Phe Asn Tyr Ser Val 
                485                 490                 495     


Lys Pro Glu Asp Lys Lys Asp Gln Pro Glu Tyr Lys Arg Thr Ala Tyr 
            500                 505                 510         


Ile Lys Ala Ala Gly Asn Leu Ala Thr Arg Gly Ala Val His Tyr Leu 
        515                 520                 525             


Glu Arg Phe Ile Ser Asp Thr Asn Gln Pro Glu Tyr Thr Arg Ala Ala 
    530                 535                 540                 


Ala Phe Trp Ala Leu Arg Arg Ala Gly Ser Lys His Pro Glu Leu Val 
545                 550                 555                 560 


Arg Asp Ile Ala Leu Pro Val Tyr Lys Asn Lys Ser Glu Ser Ser Tyr 
                565                 570                 575     


Leu Arg Ile Ala Ala Phe Thr Ala Val Met Lys Thr His Pro Asp Leu 
            580                 585                 590         


Tyr Leu Leu Lys Tyr Ile Gly His Asn Ile Ile Asp Asp Pro Ser Asp 
        595                 600                 605             


Gln Val Ala Ser Tyr Val Thr Ser Leu Phe Arg Ser Phe Glu Lys Ser 
    610                 615                 620                 


Lys Tyr Pro Cys His Gln Ser Leu Ala Gln His Leu Arg Tyr Val Val 
625                 630                 635                 640 


Pro Met Trp Asn Asp Val Tyr Arg Phe Ser Lys Pro Pro Asp Tyr Thr 
                645                 650                 655     


Lys Ser His Val His Leu Ser Ser Gly Tyr Asp Pro Lys Tyr Asp Tyr 
            660                 665                 670         


Gly Gly Ala Thr Ser Phe Gly Met Val Arg Ala Asp Asp Ser Tyr Leu 
        675                 680                 685             


Pro Arg Asp Val Tyr Val Ser Val Lys Asp Tyr Met Ser Gly His Ser 
    690                 695                 700                 


Leu Ser Thr Ala Thr Leu Trp Phe Glu Asn Trp Gly Met Asp Lys Leu 
705                 710                 715                 720 


Leu Asn His Val Val Gly Pro Gln Pro Gly Ser Ser Lys Asn Leu Trp 
                725                 730                 735     


Asn Val Phe Gly Arg Arg Arg Phe Thr Arg Asp Ala Ser Ala Lys Glu 
            740                 745                 750         


Leu Lys Glu Val Glu Asp Ala Leu Pro Val Thr Asp Arg Glu Tyr Asp 
        755                 760                 765             


His Val Tyr Gly Arg Leu Asn Leu Asp Leu Phe Gly His Ala Ile Asp 
    770                 775                 780                 


Ser Trp Glu Phe Asp Glu Asp Leu Leu Lys Glu Val Gly Lys Glu Asp 
785                 790                 795                 800 


Gly Glu Gly Lys Cys Leu Glu Ser Leu Lys Leu Leu Ile Leu Thr Asp 
                805                 810                 815     


Arg Leu Arg Lys His Lys Pro Gly Thr Lys Leu Lys Asn Leu Leu Gly 
            820                 825                 830         


Gln Val Gln Arg Lys Lys Asn Phe Tyr Leu Ser Thr Asp Ile Ile Phe 
        835                 840                 845             


Val Ala Pro Thr Glu Val Gly Val Pro Ile Phe Phe Asp Phe Lys Gln 
    850                 855                 860                 


Ala Glu Phe Thr Tyr Ile Asn Arg Lys Lys Phe Ser Val Asp Gln Thr 
865                 870                 875                 880 


Glu Asp Ala Lys Phe Thr Phe Asp Val Gln Arg His Tyr Val His Glu 
                885                 890                 895     


Ser Arg Gly Tyr Thr Met Val Gly Val Gly Leu Thr Phe Asn Lys Thr 
            900                 905                 910         


Ser Leu Gly Thr Gly Ser Asp Val Gln Thr Ile Phe Asn Leu Pro Ile 
        915                 920                 925             


Asp Leu His Leu Thr Val Asp Pro Ile His Lys Thr Leu Ser Leu Lys 
    930                 935                 940                 


Arg Pro Leu Ser Leu Pro Trp Asn Val Leu Asn His His Phe Arg Pro 
945                 950                 955                 960 


Phe Thr Phe Thr Met Pro Tyr Asp Ile Ala Thr Asp Val Ser His Ala 
                965                 970                 975     


Val Thr Thr Leu Glu Gln Pro Gln Tyr Pro Leu Tyr Asn Lys Glu Glu 
            980                 985                 990         


Val Thr Glu Ile Asp His Thr Tyr  Leu Thr Asp Val Phe  Gly Tyr Gly 
        995                 1000                 1005             


Leu Asn  Val Lys Gly Ser Leu  Leu Ser Lys Gly Leu  Lys Lys Gly 
    1010                 1015                 1020             


Leu His  Asp Phe Trp Tyr Glu  Ser Asp Cys Arg Gln  Arg Tyr Tyr 
    1025                 1030                 1035             


Tyr Ala  Leu Met Asn Pro Glu  Trp His Pro Arg Glu  Leu Gln Phe 
    1040                 1045                 1050             


Thr Val  Val Pro Ala Glu His  Asp Ala Thr Thr Glu  Val Glu Val 
    1055                 1060                 1065             


Asp Leu  Gly Tyr Lys Phe Leu  Glu Pro Asp Asp Ala  Arg Glu Ser 
    1070                 1075                 1080             


His Phe  Pro Val Gln Asp Asn  Val Gly Gly Asp Ala  Glu Val Pro 
    1085                 1090                 1095             


Ser Thr  His Val Leu Ser Leu  Asp Tyr Thr Leu Lys  Gly Ser Lys 
    1100                 1105                 1110             


Glu Arg  Lys Ala Ser Ala Glu  Leu Arg Tyr Ser Phe  Thr Lys Asp 
    1115                 1120                 1125             


Asn Leu  Lys His Lys Val Gln  Phe Phe Tyr Asp Arg  Thr Pro Phe 
    1130                 1135                 1140             


His Pro  Lys Glu Gln Val His  Thr Lys Val Cys Met  Asp Val Thr 
    1145                 1150                 1155             


Ser Lys  Phe Pro Lys Pro Glu  Trp Ser Lys Leu Lys  Asn Leu Ala 
    1160                 1165                 1170             


Val Phe  His Glu Gly Lys Asp  Leu Glu Ser Glu Leu  Asn Leu His 
    1175                 1180                 1185             


Tyr Gly  Ser Asn Cys Val Asp  Gln Ser Ser Ile Thr  Phe Lys Gly 
    1190                 1195                 1200             


Lys Tyr  Thr His Thr Asp Asp  Glu Glu Arg Gln Ile  Arg Glu Asn 
    1205                 1210                 1215             


Ala Glu  Gly Lys Pro Arg Gly  Ile Asn Arg Met Asp  Lys Tyr Asn 
    1220                 1225                 1230             


Leu Arg  Asp Pro Phe Asn Lys  Cys Thr Glu His Gln  Lys Arg Gly 
    1235                 1240                 1245             


Val Pro  Leu Asn Leu Tyr Cys  Met Lys Tyr Leu Tyr  Tyr Thr Ser 
    1250                 1255                 1260             


Arg Leu  Gly Lys Phe Thr Thr  Asp Val Glu Tyr Lys  Asn Leu Lys 
    1265                 1270                 1275             


Pro Leu  Leu Pro Met Leu Thr  Lys Tyr Tyr Lys Lys  Val His Pro 
    1280                 1285                 1290             


Glu Gly  Gly Phe Leu Ser Thr  Val Val Ser His Phe  His Gly Pro 
    1295                 1300                 1305             


Asn Gly  Lys Leu His Val Val  Ser Gln Val Pro Pro  Val Gln Asp 
    1310                 1315                 1320             


Tyr Ala  Asp Ile Val Val Thr  Thr Glu Asp Gly His  Ser His Asn 
    1325                 1330                 1335             


His Ser  His Val Pro Leu Tyr  Ser His Leu Leu Glu  Pro Arg Ile 
    1340                 1345                 1350             


Met Phe  Ser Thr Leu Gly Tyr  Ser Asn Met Ala His  Tyr Ile Ser 
    1355                 1360                 1365             


Tyr Tyr  Lys Gln Lys Tyr Cys  Asp Leu Gln Gly Gln  Ser Val Arg 
    1370                 1375                 1380             


Thr Phe  Asp Asn Val Val Val  Gln Leu Pro Glu Thr  Asp Cys Tyr 
    1385                 1390                 1395             


Lys Val  Val Ala Lys Asp Cys  Ser Pro Asn Lys Arg  Phe Thr Val 
    1400                 1405                 1410             


Leu Ala  Arg Ala Thr Gly Asn  Ala Glu Leu Pro Lys  Ala Leu Lys 
    1415                 1420                 1425             


Ala Phe  Ile Gln Thr Thr Gln  Val Glu Leu Leu Pro  Val Ala Glu 
    1430                 1435                 1440             


Asp Ser  Gly Leu Val Leu Arg  Val Asp Gly Asn Arg  Val Pro Leu 
    1445                 1450                 1455             


Thr Pro  Gly Val Pro Tyr Ser  His Thr Ala His Asp  Ala Glu Leu 
    1460                 1465                 1470             


Phe Thr  Val Thr Leu Glu Asn  Lys Tyr Phe Glu Val  Thr Ser Lys 
    1475                 1480                 1485             


Pro Tyr  Gly Leu Asn Leu Gly  Phe Asn Gly Asn Met  Leu Phe Val 
    1490                 1495                 1500             


Gln Thr  Ala Asn Phe Tyr Arg  Gly Lys Leu Cys Gly  Leu Cys Gly 
    1505                 1510                 1515             


Asp Tyr  Asn Tyr Asp Arg Gln  His Glu Leu Val Gly  Pro Asn Leu 
    1520                 1525                 1530             


His His  Tyr Asn Asp Thr Leu  Glu Phe Ala Lys Ser  Tyr Val Val 
    1535                 1540                 1545             


Pro Ser  Ser Asp Cys Thr Pro  
    1550                 1555 


<210>  5
<211>  1494
<212>  PRT
<213>  Ixodes scapularis

<400>  5

Ala Gly Tyr Glu Val Gly Asn Val Tyr Val Tyr His Tyr Asn Gly Lys 
1               5                   10                  15      


Leu Gln Val Gln Asn Pro Glu Gln Pro Leu Gln Ser Ser Gly Phe Val 
            20                  25                  30          


Phe Arg Ser Lys Val Ile Ala Gln Pro Ser Pro Asp Gly Thr His Phe 
        35                  40                  45              


Lys Ile Ile Asp Phe Glu Val Asp Ser Phe Asn Asp Glu His Thr Gln 
    50                  55                  60                  


Leu Ser Glu Gln Glu Phe His Tyr His Ser Thr Asp Ala Leu Lys Gln 
65                  70                  75                  80  


Phe Ile Glu Arg Pro Phe Ala Gly Lys Phe Ser Lys Gly Lys Leu Val 
                85                  90                  95      


Ala Ala Glu Leu Gly Lys Asn Glu Pro Lys Trp Ser Lys Asn Leu Lys 
            100                 105                 110         


Lys Gly Val Val Ser Val Phe Gln Leu Asp Leu Val Asn Gly Arg His 
        115                 120                 125             


Asp Asn Pro Asn Ala Lys Gln Phe Tyr Val Lys Glu Glu Ser Pro Leu 
    130                 135                 140                 


Gly Asn Cys Asp Thr Leu Tyr Ile Val Asp Glu Asn Glu Gly Asp Leu 
145                 150                 155                 160 


Arg Val Thr Lys Ile Lys Asn Leu Lys Lys Cys Asp Glu Gln Ile Tyr 
                165                 170                 175     


Thr Ile Gly Arg Val Lys Gly His Lys Cys Val Asp Cys Lys Ala Leu 
            180                 185                 190         


Glu Thr His Pro Gly Leu Ala Thr Ser Gln Ile Gln Tyr Ser Leu Asp 
        195                 200                 205             


Gly Thr Pro Glu His Tyr Val Ile Asn His Ala Ser Ala Thr Ser Asp 
    210                 215                 220                 


Thr Glu Phe Lys Asn Phe Gly Ala Gly Asn Thr Ile Arg Val Gln Ile 
225                 230                 235                 240 


Asn Arg Thr Leu Glu Leu Glu Glu Val Arg Ala Ala Thr Thr Asp Val 
                245                 250                 255     


Arg Leu Pro Glu Asp Ile Glu Lys Val Asp His Leu Trp Leu Ser Phe 
            260                 265                 270         


Pro Glu Ser Gly Gly Ala Asp Ser Leu Glu Glu Leu Lys Glu Val Asn 
        275                 280                 285             


Arg Phe Val Ala Asp Tyr Glu Phe Thr Ala Val Lys Asp Arg Phe Ile 
    290                 295                 300                 


Ala Gly Leu Asn Tyr Leu Val Ser Ile Glu Tyr Gly Asp Gly Asp Ile 
305                 310                 315                 320 


Arg Asp Val Asp Ser Lys Glu Ile Gly Asn Asn Phe Leu Ala Leu His 
                325                 330                 335     


Ser Ser Phe Ala Ala Met Pro Phe Glu Asp Val Ala Gln Met Tyr Asp 
            340                 345                 350         


Gln Thr Val Ala Asn Ala Pro Glu Ala Ser Lys Ser Asp Val Arg Arg 
        355                 360                 365             


Leu Phe Leu Asp Leu Leu Ser Ala Thr Gly Gly Asn Pro His Ala Ala 
    370                 375                 380                 


Phe Gly Met Gln Leu Ile Lys Glu Asp Lys Leu Ser Asp Asp Glu Ser 
385                 390                 395                 400 


Glu His Phe Leu Ser Lys Leu Ala Leu His Leu Lys Glu Asn Ser Pro 
                405                 410                 415     


Ala Leu Leu Thr Glu Leu Ala Ser Ile Cys Glu His Val Lys Pro Arg 
            420                 425                 430         


Arg His Val Trp Val Asn Cys Gln Leu Ala Leu Ser Ser Leu Ala Gly 
        435                 440                 445             


Gln Lys Gly Cys Val Arg Ala Lys Thr Asn Lys Glu His Asp Lys Gly 
    450                 455                 460                 


Ile Cys Lys Pro Ser Leu Val Ser His Phe Phe Asn Tyr Ser Ile Thr 
465                 470                 475                 480 


Pro Ser Asp Lys Lys Asp Gln Pro Glu Tyr Lys Arg Thr Val Tyr Ile 
                485                 490                 495     


Lys Thr Ala Gly Asn Leu Ala Thr Arg Ser Ala Val Leu Tyr Leu Glu 
            500                 505                 510         


Arg Phe Ile Ser Pro Glu Ala Asn Gln Pro Glu Tyr Arg Arg Ala Ala 
        515                 520                 525             


Ala Phe Trp Ala Leu Lys Gln Ser Val Pro His His Pro Glu Met Val 
    530                 535                 540                 


Arg Asp Ile Ala Leu Pro Val Tyr Met Asn Lys Ser Glu Ser Ser Tyr 
545                 550                 555                 560 


Leu Arg Ile Thr Ala Phe Val Asn Val Leu Leu Thr Asn Pro Asp Leu 
                565                 570                 575     


Tyr Leu Leu Lys Tyr Ile Gly His Asn Ile Ile Asp Asp Pro Ser Asp 
            580                 585                 590         


Gln Val Ala Ser Tyr Val Thr Ser Arg Phe Arg Ala Leu Val Asn Ser 
        595                 600                 605             


Lys Tyr Pro Cys His Gln Glu Leu Ala His His Leu Ala His Val Val 
    610                 615                 620                 


Pro Met Trp Asn Asn Val Asp Arg Phe Ser Glu Pro Leu Asp His Thr 
625                 630                 635                 640 


Gln Ser Gln Phe Thr Leu Ser Thr Ser Tyr Asp Pro Lys Tyr Asp Tyr 
                645                 650                 655     


Gly Ser Ala Thr Ala Phe Gly Leu Val Arg Ala Asp Asp Ser Tyr Leu 
            660                 665                 670         


Pro Arg Gly Ala Tyr Leu Gly Val Gln Asp Tyr Phe Gly Gly His Ser 
        675                 680                 685             


Ser Asn Thr Val Ser Leu Thr Phe Glu Asn Trp Gly Leu Asp Lys Leu 
    690                 695                 700                 


Leu Asn Arg Val Leu Gly Pro His Pro Gly Ser Thr Thr Asn Met Trp 
705                 710                 715                 720 


Asn Val Phe Gly Arg Arg Arg Phe Thr Arg Asp Ala Ser Val Glu Glu 
                725                 730                 735     


Ile Lys Glu Val Glu Asp Ala Leu Pro Val Thr Asp Arg Glu Tyr Asp 
            740                 745                 750         


His Val Tyr Gly Arg Leu Ser Leu Asp Leu Phe Gly His Ala Ile Asp 
        755                 760                 765             


Thr Trp Glu Phe Asp Glu Ser Ile Val Gln Glu Leu Thr Glu Gly Asp 
    770                 775                 780                 


Asp Thr Pro Gly Arg Lys Leu Arg Asn Leu Leu Gly Lys Val Gln Arg 
785                 790                 795                 800 


Lys Arg Ser Phe Ser Leu Ser Lys Asp Leu Leu Tyr Gly Ile Pro Thr 
                805                 810                 815     


Glu Leu Gly Val Pro Ile Tyr Ile Glu His Lys Gln Ala Glu Cys Thr 
            820                 825                 830         


Tyr Ile Asn Arg Lys Thr Phe Ser Val Asn Gln Ala Asp Asp Ala Lys 
        835                 840                 845             


Phe Ser Leu Asp Phe Lys Arg His Tyr Val His Gln Ser Gln Gly Tyr 
    850                 855                 860                 


Ser Val Val Gly Val Asn Leu Ala Phe Asn Lys Thr Phe Leu Ala Val 
865                 870                 875                 880 


Gly Ala Asn Val Gln Thr Leu Phe Asn Leu Pro Ile Asn Leu His Val 
                885                 890                 895     


Thr Val Asp Arg Val His Lys Arg Met Ser Leu Lys Arg Pro Leu Ser 
            900                 905                 910         


Leu Pro Trp Asn Val Met Asn His His Phe Arg Pro Tyr Thr Phe Val 
        915                 920                 925             


Lys Gln Tyr Gly Leu Ala Thr Asp Ala Ser Thr Thr Ala Pro Tyr Leu 
    930                 935                 940                 


Ser Gln Tyr Pro Val Tyr Asn Asn His Glu Val Thr Glu Phe Asp Arg 
945                 950                 955                 960 


Thr Tyr Phe Ala Asp Ile Phe Gly Tyr Gly Leu Asn Val Lys Gly Ser 
                965                 970                 975     


Leu Leu Ser Lys Gly Leu Lys Lys Gly Leu Gln Asn Phe Trp His Glu 
            980                 985                 990         


Ser Asp Tyr Arg Gln Lys Tyr Tyr  Tyr Ala Thr Gln Asn  Pro Glu Gly 
        995                 1000                 1005             


His Pro  Arg Asp Leu Gln Phe  Thr Leu Val Pro Ala  Glu Gly Asp 
    1010                 1015                 1020             


Ala Thr  Thr Glu Ile Gln Val  Asp Leu Gly Tyr Asn  Phe Leu Glu 
    1025                 1030                 1035             


Pro Asn  Ser Pro Arg Asp Ser  His Phe Pro Val His  Asp Asn Val 
    1040                 1045                 1050             


Gly Glu  Asp Gly Gln Val Pro  Ser Thr His Val Phe  Asn Leu Asp 
    1055                 1060                 1065             


Tyr Ala  Leu Lys Gly Thr Lys  Glu Arg Lys Val Ser  Ala Glu Leu 
    1070                 1075                 1080             


Arg Tyr  Ser Phe Thr Lys Asp  Asn Phe Arg His Lys  Val Gln Phe 
    1085                 1090                 1095             


Phe Tyr  Asp Arg Thr Pro Phe  His Pro Glu Glu Lys  Asp His Thr 
    1100                 1105                 1110             


Lys Val  Cys Leu Asp Val Thr  Ala Met Phe Pro Glu  Pro Asp Trp 
    1115                 1120                 1125             


Ala Arg  Leu Asn Asn Leu Ser  Leu Phe Tyr Glu Gly  Lys Lys Leu 
    1130                 1135                 1140             


Glu Ser  Gln Leu Tyr Leu Arg  Tyr Gly Lys Asn Cys  Val Asp His 
    1145                 1150                 1155             


Ser Ser  Ile Ile Phe Lys Ser  Lys Asn Thr His Thr  Asp Asp Glu 
    1160                 1165                 1170             


Ala Lys  Gln Ile Arg Glu Asn  Ala Glu Gly Gln Pro  Leu Gly Asn 
    1175                 1180                 1185             


Asn Arg  Leu Lys Met Tyr Lys  Leu Arg Trp Leu Phe  Lys Lys Cys 
    1190                 1195                 1200             


Thr Glu  Asp Gln Arg Arg Gly  Val Pro Leu Asn Phe  Cys Met Lys 
    1205                 1210                 1215             


Tyr Met  Tyr His Ser Ser Arg  Leu Gly Lys Phe Ala  Thr Glu Val 
    1220                 1225                 1230             


Glu Tyr  Lys Asn Leu Lys Pro  Leu Phe Ser Thr Leu  Leu Val His 
    1235                 1240                 1245             


His Met  Thr Thr Asp Pro His  Gly Ser Phe Leu Gly  Thr Leu Ala 
    1250                 1255                 1260             


Ser His  Ile His Gly Pro Asn  Gly Lys Leu His Val  Val Ser Gln 
    1265                 1270                 1275             


Val Pro  Pro Val Glu Glu Tyr  Ser Asp Ile Val Val  Thr Thr Glu 
    1280                 1285                 1290             


Asp Gly  His Ser Phe His His  Glu His Val Pro Ile  Tyr Ser His 
    1295                 1300                 1305             


Leu Leu  Ala Pro Arg Val Phe  Ser Leu Leu Gly Tyr  Ser Asn Met 
    1310                 1315                 1320             


Ala Asp  Tyr Ile Ser Tyr Tyr  Thr Gln Ser Lys Phe  Val Gly Val 
    1325                 1330                 1335             


Phe Phe  Phe Gly Val Thr Thr  Phe Asp Asp Val Val  Val Asn Leu 
    1340                 1345                 1350             


Pro Glu  Thr Asp Cys Phe Lys  Val Val Ala Lys Asp  Cys Thr Pro 
    1355                 1360                 1365             


His Lys  Arg Phe Ala Val Leu  Ala Arg Ala Thr Gly  Val Thr Lys 
    1370                 1375                 1380             


His Pro  Lys Ala Leu Lys Val  Phe Ile Gln Ser Thr  Lys Val Glu 
    1385                 1390                 1395             


Leu Phe  Pro Ala Ser His Gly  Ala Gly Leu Glu Ile  Tyr Ile Asp 
    1400                 1405                 1410             


Gly Asn  Arg Val Pro Leu Thr  Pro Gly Val Pro Tyr  Ser His Thr 
    1415                 1420                 1425             


Ala His  Asp Val Glu Leu Phe  Thr Val Thr Gln Ala  Asp Lys Phe 
    1430                 1435                 1440             


Tyr Glu  Val Thr Ser Leu Pro  Tyr Gly Leu Phe Leu  Gly Phe Asp 
    1445                 1450                 1455             


Gly Asn  Ile Leu Leu Val Gln  Thr Ala Asn Ile Tyr  Arg Gly Lys 
    1460                 1465                 1470             


Leu Cys  Gly Leu Cys Gly Asp  Tyr Asn Tyr Glu Arg  Gln His Glu 
    1475                 1480                 1485             


Leu Val  Gly Pro Asp Pro 
    1490                 


<210>  6
<211>  1325
<212>  PRT
<213>  Ixodes scapularis

<400>  6

His Pro Gly Leu Ala Thr Ser Gln Ile Lys Tyr Arg Leu Asp Gly Thr 
1               5                   10                  15      


Pro Glu His Tyr Val Ile Asn His Ala Asp Ala Thr Ser Asp Thr Glu 
            20                  25                  30          


Phe Lys Pro Phe Gly Thr Gly Gly Lys Thr Ile Arg Val Gln Ile Asn 
        35                  40                  45              


Arg Thr Leu Asp Leu Glu Glu Val His Asp Ala Asn Thr Asp Thr Gln 
    50                  55                  60                  


Leu Pro Glu Asp Ile Glu Lys Val Glu His Leu Trp Leu Ser Phe Pro 
65                  70                  75                  80  


Glu Ser Gly Asp Ala Glu Ser Leu Glu Asp Leu Lys Lys Val Asn His 
                85                  90                  95      


Pro Val Ile Asp Phe Asp Leu Thr Asn Asp Lys Glu Lys Phe Ile Pro 
            100                 105                 110         


Ala Phe Asn Gln Leu Ala Ala Thr Glu Tyr Glu Asp Asp Asp Ile Lys 
        115                 120                 125             


Asp Val His Ser Lys Glu Ser Val Ala Leu Lys Phe Leu Ile Leu His 
    130                 135                 140                 


Ser Leu Phe Gly Val Met Pro Phe Glu Asp Val Ser Gln Met Tyr Asp 
145                 150                 155                 160 


Gln Ala Val Ala Asn Ala Pro Glu Ala Gly Lys Ser Asn Val Arg Arg 
                165                 170                 175     


Leu Phe Leu Asp Leu Leu Ser Ala Thr Gly Thr Asn Pro His Val Ala 
            180                 185                 190         


Phe Gly Leu Gln Leu Ile Lys Glu Asp Lys Leu Ser Asp Asp Glu Ala 
        195                 200                 205             


Glu His Phe Leu Ser Lys Leu Ala Leu His Leu Lys Glu Asn Ser Pro 
    210                 215                 220                 


Ala Leu Met Thr Glu Leu Ser Glu Ala Cys Glu His Val Lys Pro Lys 
225                 230                 235                 240 


Arg Gln Val Trp Val Asn Cys Gln Leu Ala Leu Ser Ser Leu Ala Gly 
                245                 250                 255     


Gln Glu Gly Cys Val Arg Ala Lys Thr Asp Ser Glu His Asp Glu Gly 
            260                 265                 270         


Leu Cys Lys Pro Ser Leu Val Ser His Phe Phe Asn Tyr Gln Ile Lys 
        275                 280                 285             


Pro Glu Asp Lys Lys Asp Gln Pro Glu Tyr Lys Arg Thr Val Tyr Met 
    290                 295                 300                 


Lys Ala Ala Gly Asn Leu Ala Thr Arg Gly Ala Val His Tyr Leu Glu 
305                 310                 315                 320 


Arg Tyr Val Ser Asp Thr Asn Gln Pro Glu Tyr Arg Arg Ser Ala Ala 
                325                 330                 335     


Leu Trp Ala Leu Lys Arg Ser Ser Asn His His Pro Glu Leu Thr Gly 
            340                 345                 350         


Lys Gln Pro Val Phe Lys Asn Thr His Lys Glu Lys Leu Gly Lys Ile 
        355                 360                 365             


Phe Leu Phe Met Ala Thr Glu Ser Asn Tyr Ser Tyr Leu Asp His Asp 
    370                 375                 380                 


Val His Tyr Asn Asp Ala Lys Glu Ala Asn Ser Lys Ile Asp Ser Asn 
385                 390                 395                 400 


Thr Leu Phe Leu Asn Leu Cys Ala Phe Pro Gln Lys Lys Lys Lys Ser 
                405                 410                 415     


Lys Asn Arg His Arg Asn Pro Gln His Leu Arg Tyr Val Val Pro Met 
            420                 425                 430         


Trp Asn Asp Val Pro Arg Phe Asp Lys Pro Leu Asp His Thr Lys Ser 
        435                 440                 445             


Gln Leu Leu Ile Ser Ser Gly Tyr Asp Pro Lys Tyr Asp Tyr Gly Gly 
    450                 455                 460                 


Ala Thr Thr Phe Gly Gln Ile Arg Ala Asp Asp Ser Tyr Leu Pro Arg 
465                 470                 475                 480 


Glu Val Tyr Leu Gly Phe Lys His Tyr Tyr Ser Gly Ala Ser Tyr Glu 
                485                 490                 495     


Thr Ala Ser Leu Trp Phe Glu Ser Trp Gly Met Asp Lys Leu Leu Asn 
            500                 505                 510         


His Ala Ile Gly Pro Arg Pro Gly Ser Thr Ala Asn Met Trp Asn Val 
        515                 520                 525             


Phe Gly Arg Arg Arg Phe Pro Arg Asp Ala Ser Ala Lys Glu Leu Lys 
    530                 535                 540                 


Glu Ile Glu Asp Ala Leu Pro Val Thr Asp Arg Glu Tyr Asp His Val 
545                 550                 555                 560 


Tyr Gly Arg Leu Ser Leu Asp Leu Phe Gly Arg Ala Ile Asp Thr Phe 
                565                 570                 575     


Glu Phe Asp Glu Ser Leu Phe Glu Glu Ala Ala Asn Ala Arg Gly Glu 
            580                 585                 590         


Phe Leu Asp Ser Phe Arg His Glu Val Pro Arg Gly Lys Gln Leu Tyr 
        595                 600                 605             


Gln Ser Ala Ser Lys Leu Glu Ser Phe Leu Glu Pro Glu Ser Pro Ala 
    610                 615                 620                 


Pro Ile Ser Thr Gln Glu Val Lys Pro Tyr Tyr Glu Val Tyr Leu Leu 
625                 630                 635                 640 


Asn Gln Val Gly Val Cys His Asp Asp Ser Trp Leu Arg His Val Ala 
                645                 650                 655     


Tyr Gly Ile Ala Lys Cys Ser Lys Asn Pro Ser Arg Thr Ser Asn Met 
            660                 665                 670         


Val Gly Val Gly Leu Thr Phe Asn Lys Thr Phe Val Gly Val Gly Ala 
        675                 680                 685             


Asp Ile Gln Thr Val Phe Asn Leu Pro Ile Asp Leu Lys Val Thr Val 
    690                 695                 700                 


Asp Pro Ile His Lys Lys Leu Ser Leu Asn Arg Pro Leu Ser Leu Pro 
705                 710                 715                 720 


Trp Asn Ile Val Asn His His Phe Arg Pro Tyr Thr Phe Ala Met Pro 
                725                 730                 735     


Tyr Asp Leu Val Ser Asp Val Ser Thr Ala Val Thr Ala Leu Ser Gln 
            740                 745                 750         


Pro Gln Tyr Pro Leu Tyr Asn Lys Asp Glu Val Thr Ser Phe Asp Arg 
        755                 760                 765             


Thr Tyr Phe Thr Asp Leu Leu Gly Tyr Gly Leu Asn Val Lys Gly Ser 
    770                 775                 780                 


Leu Leu Ser Lys Gly Leu Lys Lys Gly Leu His Asp Phe Leu Leu His 
785                 790                 795                 800 


Ser Asp Cys Ser Lys Met Leu Tyr Tyr Ala Val Trp Asn Pro Glu Trp 
                805                 810                 815     


His Pro Arg Glu Leu Gln Leu Thr Val Val Pro Asp Glu Gln Asp Ala 
            820                 825                 830         


Thr Thr Glu Val Glu Val Lys Leu Gly Tyr Glu Phe Leu Glu Pro Asp 
        835                 840                 845             


Asp Pro Arg Glu Ser His Phe Pro Val Asn Asp Asn Val His Gly Asp 
    850                 855                 860                 


Ala Glu Val Pro Ser Thr His Val Leu Asn Leu Asp Tyr Ala Leu Lys 
865                 870                 875                 880 


Gly Thr Lys Glu Arg Lys Val Ser Ala Glu Leu Arg Tyr Ser Tyr Thr 
                885                 890                 895     


Lys Asp Asn Leu Lys His Lys Val Gln Phe Phe Ser Asp Arg Thr Pro 
            900                 905                 910         


Phe His Ser Met Asp Gln Asp His Ser Lys Ile Cys Leu Asp Val Thr 
        915                 920                 925             


Thr Lys Phe Pro Glu Pro Asp Trp Asp Arg Leu Asn Asn Leu Ala Val 
    930                 935                 940                 


Phe His Glu Gly Lys Glu Leu Glu Phe Gln Met Asn Ile His Gln Gly 
945                 950                 955                 960 


Ser Asn Cys Ile Asp Gln Ala Ser Val Ser Phe Thr Gly Lys Tyr Thr 
                965                 970                 975     


His Thr Asp Asp Glu Ala Lys Gln Ile Arg Glu Asn Ala Glu Gly Lys 
            980                 985                 990         


Pro Leu Gly Ala Asn Arg Met Lys  Lys Tyr Asn Leu Arg  Val Pro Tyr 
        995                 1000                 1005             


Asn Lys  Cys Val Glu His Gln  Lys Gln Gly Val Pro  Leu Asn Tyr 
    1010                 1015                 1020             


Tyr Cys  Ile Lys Tyr Leu Tyr  Tyr Thr Ser Arg Leu  Gly Lys Leu 
    1025                 1030                 1035             


Thr Met  Asp Ile Val Tyr Lys  Asn Arg Trp Asp Leu  Phe Ser Pro 
    1040                 1045                 1050             


Met Pro  His Tyr Tyr Lys Lys  Ile Asn Arg Glu Gly  Gly Phe Val 
    1055                 1060                 1065             


Ser Thr  Leu Ser Glu Tyr Tyr  Arg Arg Ala Thr Ser  Gly Lys Leu 
    1070                 1075                 1080             


His Val  Val Ser Gln Val Pro  Pro Val Glu Lys Tyr  Ala Asp Ile 
    1085                 1090                 1095             


Ala Val  Thr Thr Glu Asp Gly  Arg Ile Tyr Asn His  Phe His Val 
    1100                 1105                 1110             


Pro Ile  Tyr Ser His Leu Leu  Glu Pro Lys Ile Phe  Pro Met Leu 
    1115                 1120                 1125             


Gly Tyr  Ser Asn Met Ala Asn  Tyr Ile Ser Tyr Tyr  Lys His Thr 
    1130                 1135                 1140             


Asn Thr  Ala Ile Ile Ser Cys  Leu Phe Val Pro Phe  Tyr Thr Pro 
    1145                 1150                 1155             


Gly Asn  Leu Val Leu Asn Trp  His Arg Ser Pro Gln  Pro Arg Arg 
    1160                 1165                 1170             


Leu Gln  Asn Leu Lys Phe Thr  Gly Thr Phe Tyr Arg  His Ser Pro 
    1175                 1180                 1185             


Ser Val  Ile Leu Leu Gln Ala  Leu Lys Ala Phe Ile  Gln Ser Thr 
    1190                 1195                 1200             


Gln Val  Glu Leu Leu Pro Val  Ala Glu Asp Ser Gly  Leu Val Leu 
    1205                 1210                 1215             


Arg Val  Asp Gly Asn Arg Val  Pro Leu Thr Pro Gly  Val Pro Tyr 
    1220                 1225                 1230             


Ser His  Thr Ala His Glu Val  Glu Leu Phe Thr Val  Lys Met Glu 
    1235                 1240                 1245             


His Asn  Tyr Phe Glu Val Thr  Ser Lys Pro Tyr Gly  Leu Tyr Leu 
    1250                 1255                 1260             


Gly Phe  Asn Gly Asn Met Leu  Val Val Gln Thr Ala  Asn Phe Tyr 
    1265                 1270                 1275             


Arg Gly  Lys Leu Cys Gly Leu  Cys Gly Asp Tyr Asn  Tyr Asp Arg 
    1280                 1285                 1290             


Gln His  Glu Leu Val Gly Pro  Asn Leu His His Tyr  Asn Glu Thr 
    1295                 1300                 1305             


Leu Glu  Phe Ala Lys Ser Tyr  Val Val Pro Ser Ser  Asp Cys Thr 
    1310                 1315                 1320             


Pro Pro  
    1325 


<210>  7
<211>  1111
<212>  PRT
<213>  Ixodes scapularis

<400>  7

Met Ser Leu Gln Asn Arg Ala Leu Glu Asp Ser Ala Phe Glu Thr Gly 
1               5                   10                  15      


Lys Glu Tyr Val Tyr His Tyr Asn Gly Arg Leu Gln Ile Lys Asn Pro 
            20                  25                  30          


Glu Gln Pro Leu Gln Ser Ser Gly Phe Ala Phe Arg Ser Lys Val Val 
        35                  40                  45              


Ala Gln Pro Lys Ser Asp His Thr Tyr Phe Lys Ile Thr Asp Phe Glu 
    50                  55                  60                  


Val Asp Ser Phe Asn Gly Asp Arg Ile Ile Leu Asp Asp His Gln Phe 
65                  70                  75                  80  


Asn Tyr His Ser Thr Asp Asp Leu Arg Glu Phe Ile Glu Arg Pro Phe 
                85                  90                  95      


Ala Gly Thr Phe Ser His Gly Lys Ile Val Glu Ile Ala Ile Gly Arg 
            100                 105                 110         


Glu Glu Pro Leu Trp Ser Lys Asn Leu Lys Lys Gly Val Leu Ser Thr 
        115                 120                 125             


Phe Gln Leu Asp Leu Val Thr Gly Arg Gln Asn Asn Pro His Val Glu 
    130                 135                 140                 


Glu Tyr Thr Thr Arg Glu His Gly Leu His Gly Asn Cys Glu Thr Lys 
145                 150                 155                 160 


Tyr Leu Val Thr Glu Lys Glu Gly His Ile Glu Val Phe Lys Val Arg 
                165                 170                 175     


Asp Leu Asp Leu Cys Asp Lys Glu Ala His Ile Val Tyr Gly Arg Ile 
            180                 185                 190         


Lys Gly His Lys Cys Val Glu Cys Glu Ala Met Glu Thr His Pro Leu 
        195                 200                 205             


Ser Ser Thr Phe Glu Val Lys Tyr Arg Leu Asp Gly Thr Pro Gln His 
    210                 215                 220                 


Tyr Val Ile Lys His Ala Ser Ala Ala Ser Asp Thr Leu Phe Gln Pro 
225                 230                 235                 240 


Phe Gly Ala Gly Lys Ala Val Arg Val Val Val Asn Arg Thr Leu Phe 
                245                 250                 255     


Leu Asp Glu Glu Arg Ala Ala Asn Ala Asp Met Gln Leu Pro Asp Asp 
            260                 265                 270         


Val Gly Val Ser Asp Glu Leu Thr His Ser Phe Ser Glu Tyr Gly Lys 
        275                 280                 285             


Ala Gln Thr Leu Glu Asp Leu Lys His Pro Asn His Tyr Ile Thr Asp 
    290                 295                 300                 


Ser Lys Leu Gln Asn Gly Arg Gln Lys Phe Val Glu Gly Leu Asn His 
305                 310                 315                 320 


Leu Ala Ala Phe Gly Tyr Asp Asp Ser Asp Ile Gly Ser Val Asp Thr 
                325                 330                 335     


Lys Glu Ser Gly Ala Leu Arg Phe Leu Leu Leu Phe Arg Ser Met Ala 
            340                 345                 350         


Ser Met Arg Tyr Glu Asp Ile Glu Gln Val Tyr Glu Gln Asn Val Val 
        355                 360                 365             


Asn Ala Pro Glu Pro Asn Arg Gln Asn Val Arg Arg Leu Phe Leu Asp 
    370                 375                 380                 


Val Leu Ala Ala Ala Gly Ser Asn Pro His Val Ala Phe Gly Leu Lys 
385                 390                 395                 400 


Leu Leu Lys Glu Gly Lys Leu Ser Gly Gly Asp Ala Glu His Phe Leu 
                405                 410                 415     


Thr Arg Leu Pro Leu Asn Leu Lys Glu His Ser Pro Ala Leu Ile Thr 
            420                 425                 430         


Gln Leu Ala Val Arg Leu Arg Leu Phe Arg Ser Val Gln His Leu Arg 
        435                 440                 445             


Tyr Val Val Pro Leu Trp Asp Asn Val Gln Arg Phe Ser Lys Pro Leu 
    450                 455                 460                 


Asp Tyr Thr Gln Ser Gln Leu Ala Leu Ser Ser Gly Tyr Asp Pro Glu 
465                 470                 475                 480 


Tyr Asp Tyr Gly Gly Ala Thr Ile Phe Ser Met Ile Gln Ala Asp Asp 
                485                 490                 495     


Ser Tyr Leu Pro Arg Ser Leu Tyr Leu Lys Ala Lys Asp Tyr Tyr Ala 
            500                 505                 510         


Gly Tyr Ser Tyr Asp Thr Ile Ala Met Ser Phe Glu Gly Trp Gly Leu 
        515                 520                 525             


Asn Lys Leu Ile Asp Gly Val Ala Gly Pro Arg Pro Gly Ser Thr Lys 
    530                 535                 540                 


Asn Leu Trp Asn Phe Gly Gly Arg Arg Arg Phe Thr Arg Glu Ala Ser 
545                 550                 555                 560 


Ala Lys Asp Arg Lys Glu Ile Glu Asp Ala Leu Pro Ile Gln Asp Trp 
                565                 570                 575     


Pro Phe Asp Pro Phe Tyr Ala Arg Ile Gly Leu Ser Met Tyr Gly Asn 
            580                 585                 590         


Glu Ile Asp Thr Trp Glu Ile Asp Glu Arg Met Leu Ala Glu Leu Lys 
        595                 600                 605             


Glu Ser Asp Lys Pro Gly Asp Asp Pro Trp Asp Ile Leu Thr Lys Lys 
    610                 615                 620                 


Val Arg Arg Lys Ser Phe Phe Leu Asn Asn Asp Tyr Val Leu Leu Val 
625                 630                 635                 640 


Pro Thr Asp Met Gly Val Ser Val Phe Met Asp Phe Lys Ser Val Asp 
                645                 650                 655     


Phe Ala Phe Ile Asp Arg Gln Lys Phe Asp Phe Ala Arg Thr Ala Asp 
            660                 665                 670         


Asp Lys Phe Ser Leu Asp Val Lys Arg Arg Tyr Val Phe Glu Asn Arg 
        675                 680                 685             


Gly Phe Ser Val Val Gly Val Ala Leu Thr Phe Asn Glu Thr Ala Val 
    690                 695                 700                 


Gly Ser Gly Ser Asp Ser Arg Thr Val Leu Ser Leu Pro Leu Glu Leu 
705                 710                 715                 720 


Lys Ala Thr Leu Asp Thr Leu Asn His Lys Leu His Leu Gln Arg Pro 
                725                 730                 735     


Leu Ala Leu Pro Trp Asn Ile Leu Asn His His Asn Arg Pro Ser Thr 
            740                 745                 750         


Phe Ala Leu Pro Phe Asp Pro Thr Arg Asp Ile Gly Asn Ala Val Ile 
        755                 760                 765             


Gln Leu Ala Asp Pro Pro Thr Pro Leu Tyr Asn Lys Phe Glu Leu Thr 
    770                 775                 780                 


Glu Ile Asp Arg Gly Phe Arg Thr Asp Ser Leu Pro Ile Gly Leu Asn 
785                 790                 795                 800 


Val Glu Gly Ser Met Leu Ser Lys Gly Leu Ser Glu Gly Leu His Lys 
                805                 810                 815     


Phe Trp Tyr Glu Met Asp Trp Arg Gln Lys Phe Tyr Tyr Ala Ala Met 
            820                 825                 830         


Asn Pro His Trp His Pro Arg Glu Leu Arg Leu Thr Leu Val Glu Ala 
        835                 840                 845             


Glu Lys Asn Phe Pro Thr Thr Ile Glu Leu Asp Leu Ser His Lys Phe 
    850                 855                 860                 


Leu Lys Pro Glu Asp Ala Arg Glu Ser Lys Phe Pro Ile Thr Phe Asn 
865                 870                 875                 880 


Gly Lys Phe Thr His Thr Asp Asp Asp Ala Gln Gln Ile Arg Glu Asn 
                885                 890                 895     


Ala Glu Ala Lys Pro Arg Ser Pro Asn Arg Leu Arg Pro Tyr Tyr Leu 
            900                 905                 910         


Arg Asp Met Tyr Ala Lys Cys Val His His Gln Lys Leu Gly Ile Pro 
        915                 920                 925             


Leu Asn Tyr Tyr Cys Val Lys Tyr Met Tyr Tyr Ser Ser Arg Leu Gly 
    930                 935                 940                 


Lys Leu Thr Met Asp Val Glu Tyr Lys Lys Leu Lys Pro Leu Leu Pro 
945                 950                 955                 960 


Gly Leu Tyr Tyr His Met Thr Glu Tyr His Ser His Ser Glu Asp His 
                965                 970                 975     


Val Gly Phe Phe Gly Val Ile Gly Glu His Met Asp Gly Pro Thr Gly 
            980                 985                 990         


Lys Leu Arg Val Val Ser Gln Val  Pro Pro Arg His Lys  Cys Ala Asp 
        995                 1000                 1005             


Val Leu  Val Ser Thr Ser Asp  Gly His His Phe Phe  His Pro His 
    1010                 1015                 1020             


Val Pro  Leu Tyr Ser His Ile  Leu Glu Pro Arg Val  Phe Val Ala 
    1025                 1030                 1035             


Phe Gly  Tyr Ser Asn Ile Ala  Glu Tyr Thr Ala Tyr  Tyr Lys Gln 
    1040                 1045                 1050             


Ser Glu  Tyr Gly Pro Pro Thr  Ala Ser Phe Tyr Arg  Gly Ser Leu 
    1055                 1060                 1065             


Cys Gly  Leu Cys Ala Asp Tyr  Asn Tyr Asp Arg Leu  Asn Glu Leu 
    1070                 1075                 1080             


Leu Gly  Ser Asp His Gln Val  His Asn Asp Thr Leu  Glu Phe Ala 
    1085                 1090                 1095             


Glu Ser  Tyr Val Val Pro Ser  Ser Asp Cys Thr Pro  Pro 
    1100                 1105                 1110     


<210>  8
<211>  480
<212>  PRT
<213>  Ixodes scapularis

<400>  8

Met Ile Tyr Gln Thr Cys Val Val Lys Tyr His Asn Thr Trp Asn Asp 
1               5                   10                  15      


Ala Lys Glu Asn Ala Ile Cys Thr Pro Thr Met Ala Ala Lys Tyr Phe 
            20                  25                  30          


Asn Tyr Leu Val Pro Gln Tyr Glu Arg Asn Leu Glu Glu Lys Glu Arg 
        35                  40                  45              


Thr Met Tyr Ile Lys Val Ala Gly Asn Phe Gly Leu Lys Glu Ala Leu 
    50                  55                  60                  


Pro Phe Leu Glu Lys Tyr Ala Glu Asp Lys Met Asp Gln Phe Pro Val 
65                  70                  75                  80  


His Ile Arg Met Ile Ser Ile Trp Val Leu Glu Lys Ala Ala Leu Tyr 
                85                  90                  95      


Asn Pro Glu Lys Val Arg Asp Ile Val Leu Pro Ile Tyr Arg Asn Trp 
            100                 105                 110         


Thr Glu Ser His Glu Ile Arg Leu Ala Ala Phe Thr Ile Leu Met Arg 
        115                 120                 125             


Thr Ser Pro Asp Met Ala Leu Leu Lys Ser Ile Ala Ala Glu Leu Val 
    130                 135                 140                 


Thr Thr Glu Pro Asn Thr Gln Val Ile Ser Tyr Val Trp Ser Thr Phe 
145                 150                 155                 160 


Lys His Met Ala Glu Leu Asp Tyr Pro Cys Tyr Phe Glu Ile Ala Arg 
                165                 170                 175     


His Leu Glu Tyr Val Met Pro Ile Ile Glu Gly His Glu Arg Leu Lys 
            180                 185                 190         


Asp Leu Glu Glu Trp Pro Tyr Ser Lys Lys Ile Ile Asn Gly Gly Tyr 
        195                 200                 205             


Glu Pro Glu Phe Asp Tyr Gly Gly Tyr Ser Val Phe Ser Tyr Ile Met 
    210                 215                 220                 


Ala Asn Asp Ser Tyr Met Pro Arg Ser Met Tyr Ile Lys Met Asn Asp 
225                 230                 235                 240 


Tyr Met Asn Asn Phe Asn Tyr Asp Thr Phe Ser Ala Ser Phe Asp Gly 
                245                 250                 255     


Trp Gly Leu Glu Pro Ile Leu Asp Lys Met Phe Gly Pro Lys Val Lys 
            260                 265                 270         


Gly Asp Ile Ser Pro Gly Arg Ser Leu Trp Asn Phe Phe Gly Arg Arg 
        275                 280                 285             


Arg Ser Thr Arg Asp Ile Ala Val His Lys Glu Val Lys Glu Ile Asp 
    290                 295                 300                 


Gln Asn Leu His Ile Glu Thr Arg Asn His Pro Lys Pro Tyr Ala Ala 
305                 310                 315                 320 


Leu Arg Val Thr Ala Phe Asn Asn Glu Leu Ile Asn Leu Asn Phe Asp 
                325                 330                 335     


Glu Glu Met Phe Asp Thr Ile Met Thr Ser Gly Glu Asn Arg Pro Met 
            340                 345                 350         


Ser Ile Leu Arg Lys Ile Val Gly Asp Ile Lys Asp Phe Gln Val Arg 
        355                 360                 365             


Ser Phe Met Met Asp Gly Asp Met Ser Met Phe Leu Pro Thr Glu Ile 
    370                 375                 380                 


Gly Leu Pro Phe Tyr Leu Glu Arg Lys Gln Pro Met Phe Met Tyr Tyr 
385                 390                 395                 400 


Lys Asn Lys Glu Met Lys Phe Asp Val Lys Gly Asn Glu Ala Asp Gly 
                405                 410                 415     


Thr Ile Asp Glu Ile Thr Thr Lys Ile Asn Gly His Phe Met Phe Asp 
            420                 425                 430         


His His Thr Ile Glu Thr Ala Ser Ile Leu Val Pro Phe Glu Lys Ile 
        435                 440                 445             


Ser Val Gly Val Gly Tyr Asp Ser Arg Ile Ala Met Ser Ile Pro Val 
    450                 455                 460                 


Asp Ile Asp Ala Gly Met Asn Met Val Asp Arg Lys Phe Arg Met Lys 
465                 470                 475                 480 


