﻿                         序列表

<110>  百奥泰生物制药股份有限公司

<120>  抗CD73抗体及其应用

<150>  PCT/CN2021/095287
<151>  2021-05-21

<160>  31

<170>  SIPOSequenceListing 1.0

<210>  1
<211>  5
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  1
Thr Tyr Ala Met Ser 
1               5   

<210>  2
<211>  17
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  2
Ala Ile Ser Gly Asp Thr Gly Val Thr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210>  3
<211>  13
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  3
Asp Arg Tyr Ala Tyr Leu Val Asp Gly Trp Phe Asp Tyr 
1               5                   10              

<210>  4
<211>  11
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  4
Arg Ala Ser Gln Gly Ile Ser Ser Tyr Leu Ala 
1               5                   10      

<210>  5
<211>  7
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  5
Ala Ala Ser Ser Leu Gln Ser 
1               5           

<210>  6
<211>  11
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  6
Gln Gln Ala Ser Tyr Thr Gly Asp Pro Val Thr 
1               5                   10      

<210>  7
<211>  11
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  7
Ala Gln Tyr Asp Phe Ser Phe Tyr Gly Val Thr 
1               5                   10      

<210>  8
<211>  11
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  8
Gln Thr Ser Asp Phe Phe Pro Asn Pro Val Thr 
1               5                   10      

<210>  9
<211>  11
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  9
Gln Thr Trp Ser Gly Trp Pro Asp Tyr Leu Thr 
1               5                   10      

<210>  10
<211>  122
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  10
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Asp Thr Tyr 
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ala Ile Ser Gly Asp Thr Gly Val Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Asp Arg Tyr Ala Tyr Leu Val Asp Gly Trp Phe Asp Tyr Trp 
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         

<210>  11
<211>  109
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  11
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Tyr 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Ser Tyr Thr Gly Asp 
                85                  90                  95      
Pro Val Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 

<210>  12
<211>  109
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  12
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Tyr 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gln Tyr Asp Phe Ser Phe Tyr 
                85                  90                  95      
Gly Val Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 

<210>  13
<211>  109
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  13
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Tyr 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Thr Ser Asp Phe Phe Pro Asn 
                85                  90                  95      
Pro Val Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 

<210>  14
<211>  109
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  14
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Tyr 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Thr Trp Ser Gly Trp Pro Asp 
                85                  90                  95      
Tyr Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 

<210>  15
<211>  330
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  15
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      
Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 

<210>  16
<211>  327
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  16
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      
Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  
Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      
Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         
Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 
Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             
Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             
Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 
Leu Ser Leu Ser Leu Gly Ala 
                325         

<210>  17
<211>  107
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  17
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         

<210>  18
<211>  452
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  18
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Asp Thr Tyr 
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ala Ile Ser Gly Asp Thr Gly Val Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Asp Arg Tyr Ala Tyr Leu Val Asp Gly Trp Phe Asp Tyr Trp 
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             
His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 
Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         
Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        355                 360                 365             
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             
Ser Pro Gly Lys 
    450         

<210>  19
<211>  449
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  19
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Asp Thr Tyr 
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ala Ile Ser Gly Asp Thr Gly Val Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Asp Arg Tyr Ala Tyr Leu Val Asp Gly Trp Phe Asp Tyr Trp 
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             
Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr 
    130                 135                 140                 
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         
Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp 
        195                 200                 205             
His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr 
    210                 215                 220                 
Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro 
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
            260                 265                 270         
Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         
Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
                405                 410                 415     
Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445             
Ala 
    

<210>  20
<211>  216
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  20
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Tyr 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Ser Tyr Thr Gly Asp 
                85                  90                  95      
Pro Val Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val 
            100                 105                 110         
Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
        115                 120                 125             
Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
    130                 135                 140                 
Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
145                 150                 155                 160 
Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
                165                 170                 175     
Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
            180                 185                 190         
Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
        195                 200                 205             
Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215     

<210>  21
<211>  216
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  21
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Tyr 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gln Tyr Asp Phe Ser Phe Tyr 
                85                  90                  95      
Gly Val Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val 
            100                 105                 110         
Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
        115                 120                 125             
Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
    130                 135                 140                 
Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
145                 150                 155                 160 
Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
                165                 170                 175     
Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
            180                 185                 190         
Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
        195                 200                 205             
Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215     

<210>  22
<211>  216
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  22
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Tyr 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Thr Ser Asp Phe Phe Pro Asn 
                85                  90                  95      
Pro Val Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val 
            100                 105                 110         
Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
        115                 120                 125             
Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
    130                 135                 140                 
Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
145                 150                 155                 160 
Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
                165                 170                 175     
Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
            180                 185                 190         
Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
        195                 200                 205             
Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215     

<210>  23
<211>  216
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  23
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Tyr 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Thr Trp Ser Gly Trp Pro Asp 
                85                  90                  95      
Tyr Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val 
            100                 105                 110         
Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
        115                 120                 125             
Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
    130                 135                 140                 
Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
145                 150                 155                 160 
Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
                165                 170                 175     
Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
            180                 185                 190         
Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
        195                 200                 205             
Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215     

<210>  24
<211>  1356
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  24
gaggttcagt tggtagagtc cggcggaggg ttggtgcagc ctggggggtc gcttcgctta        60
agctgcgcgg cgtcagggtt ttcgtttgat acatatgcta tgagctgggt tcgacaggca       120
ccgggtaagg gtctggagtg ggtaagcgcc ataagcggtg acacaggagt gacaggttac       180
gcagatagcg tgaagggacg atttacgatc tctagagaca attcaaaaaa taccctatac       240
ttgcagatga attcgttgcg agcagaggat acggcggtat actattgtgc aagagaccgc       300
tatgcatatt tggttgatgg gtggttcgat tactggggac aagggactct cgttaccgtt       360
tctagcgcat cgacaaaagg accgagtgtt ttcccgctcg cgcccagttc gaagtccaca       420
tctggtggta cagccgcact tggttgtctg gttaaagact acttccccga accagtcact       480
gtcagttgga atagtggtgc actcactagc ggagtccata cctttcctgc agtattgcag       540
tcgtccgggt tgtactccct gtcctcggtt gtaacggttc cgtctagtag tttgggaaca       600
caaacttaca tttgtaatgt caatcacaaa ccaagtaaca caaaggtaga caaaaaggtt       660
gaaccgaagt cctgtgacaa aacgcataca tgccctccgt gccccgctcc tgagcttctc       720
ggcgggccgt ccgtgttcct ttttccaccc aaaccaaaag atacgttaat gatcagccgg       780
acaccagaag taacatgcgt agtggtagac gtgagccacg aagatccgga agtcaagttt       840
aactggtacg tcgacggggt tgaggtgcac aatgctaaga cgaaaccacg tgaagaacag       900
tataactcca cctaccgtgt ggtatcggta ctgacggttt tacatcagga ttggctgaac       960
ggaaaggagt ataaatgcaa agtcagtaac aaagcgcttc cagctcccat tgagaagact      1020
atttccaagg ctaaaggaca gccgcgagag cctcaggtgt atacgctgcc accatcccga      1080
gacgagctta ctaagaatca agttagcctg acatgcctcg tgaaaggttt ttatccaagc      1140
gatatcgcgg ttgagtggga gtcgaacggc cagccagaga ataattacaa aacaacgcct      1200
ccggttcttg attcggatgg ctcgttcttt ctgtattcga aattgactgt tgataaaagt      1260
cgttggcagc aggggaatgt cttcagttgc agcgtaatgc atgaagccct acacaaccac      1320
tacacacaaa agagtttatc gttatctcca ggtaag                                1356

<210>  25
<211>  1347
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  25
gaggtgcagc tggtggagag cggcggcgga ctggtgcagc ctggaggaag cctgcggctg        60
tcctgcgctg ctagcggctt cagctttgac acctacgcca tgagctgggt gcggcaggcc       120
cctggaaagg gcctggagtg ggtgtccgcc atctccggcg acaccggcgt gaccggatat       180
gctgactccg tgaagggcag gtttaccatc agccgggata actccaagaa caccctgtat       240
ctgcagatga acagcctgag ggccgaggat accgccgtgt attactgcgc tagggacagg       300
tacgcctatc tggtggacgg ctggttcgac tactggggcc agggcaccct ggtgaccgtg       360
agctccgcca gcaccaaggg cccttccgtg tttcccctgg ctccctgctc caggtccacc       420
agcgagtcca ccgccgccct gggatgtctg gtgaaggatt atttccctga gcccgtgacc       480
gtgtcctgga atagcggcgc tctgacctcc ggcgtgcaca ccttccctgc cgtgctgcag       540
tcctccggcc tgtattccct gagctccgtg gtgaccgtgc ccagcagctc cctgggcacc       600
aagacctaca cctgcaacgt ggatcacaag cctagcaaca ccaaggtgga caagagggtg       660
gagagcaagt acggcccccc ctgcccccca tgtcctgctc ctgagttcct gggcggcccc       720
agcgtgttcc tgttcccccc taagcccaag gataccctga tgatcagcag gacccccgag       780
gtgacctgcg tggtggtgga cgtgagccag gaggatcccg aggtgcagtt taactggtac       840
gtggatggcg tggaggtgca caacgccaag accaagcccc gggaggagca gtttaacagc       900
acctacaggg tggtgtccgt gctgaccgtg ctgcaccagg actggctgaa tggcaaggag       960
tataagtgca aggtgagcaa caagggcctg cccagcagca tcgagaagac catcagcaag      1020
gccaagggcc agccccggga gcctcaggtt tataccctgc ccccttccca ggaggagatg      1080
accaagaacc aggtgtccct gacctgtctg gtgaaaggct tctacccctc cgatatcgcc      1140
gtggagtggg agtccaacgg ccagcccgag aataattaca agaccacccc tcctgtgctg      1200
gattccgatg gctccttctt cctgtactcc cggctgaccg tggataagag caggtggcag      1260
gagggcaacg tgtttagctg cagcgtgatg cacgaggctc tgcacaacca ctacacccag      1320
aagagcctga gcctgtccct gggcgct                                          1347

<210>  26
<211>  648
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  26
gatatacaaa tgactcagag tccaagttcg cttagtgcaa gcgttggcga tagggtcact        60
atcacctgca gagcctcaca gggcatttct agttacttag cgtggtacca gcagaagccg       120
ggcaaagcac caaagttgct tatctacgca gctagttccc tgcaatctgg agtaccgtca       180
cggtttagcg gtagcggttc tgggacggac ttcacactca cgatctcttc tctacagcct       240
gaagacttcg cgacttatta ttgccaacag gcatcataca caggtgatcc tgttacgttc       300
ggccagggca cgaaagtaga aatcaagcgg acagttgccg ccccttccgt tttcatattt       360
cccccttcag acgagcagct aaaatcgggg actgcctcgg ttgtgtgtct tctaaataat       420
ttttatccca gagaggcaaa ggttcagtgg aaagtggata acgcgctcca gtccggaaac       480
agtcaggaat cagttacaga acaggacagt aaggactcaa catattcgct cagttccacg       540
ttgacattgt cgaaggcaga ttacgagaag cataaagtgt acgcatgcga ggtgacccac       600
caagggctct cctcccctgt gaccaaaagc tttaacaggg gagaatgt                    648

<210>  27
<211>  648
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  27
gatattcaga tgacgcaaag cccgtcatct ctcagcgcaa gtgtcggcga ccgcgtcact        60
attacatgtc gtgcttctca gggtataagc tcatatctcg cctggtatca acagaagcct       120
ggcaaagcac cgaagctact aatttatgca gcttcgagtt tacagtctgg cgtccccagt       180
cggttctcag gttccggctc gggtacagat tttactttga cgatttcttc gctccagcca       240
gaagatttcg ccacgtatta ttgcgcccaa tacgacttta gcttctacgg tgtcaccttc       300
ggccaaggaa caaaagtaga aattaagcgc acggtcgccg ccccttcagt atttattttc       360
cccccaagcg atgagcaact aaaaagcggt actgcctctg ttgtatgcct tctcaataat       420
ttctatccta gggaggctaa ggtgcagtgg aaagtagata atgcactcca gtcgggtaac       480
tcccaagaat ctgtcactga gcaggattcc aaagattcta cttattccct ctctagcaca       540
ctgacactga gtaaagcgga ctacgagaaa cacaaggttt atgcctgcga agtcactcat       600
caaggcctgt cgagtcctgt cactaagtct tttaataggg gcgaatgc                    648

<210>  28
<211>  648
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  28
gatatccaga tgacccagtc cccgagcagt ctgtccgcga gcgtaggaga ccgcgtgacc        60
attacatgca gggccagtca gggcattagt tcatatctag catggtatca gcaaaaacca       120
ggtaaggccc caaaattgct tatttacgct gcttcaagtc tacaaagcgg agtgccgagc       180
aggttttccg ggtcaggatc gggaacagac ttcaccctca cgataagttc cttgcaacct       240
gaggactttg ccacgtatta ctgccaaaca agcgattttt ttccaaatcc tgtaacgttt       300
ggtcaaggaa ccaaagtaga aatcaaacgg actgtagccg cgccctcagt gttcatcttt       360
cctccgtcag atgagcaact caagtctggg acggcgtcag tcgtgtgttt actaaataac       420
ttctacccaa gagaagcgaa agtgcaatgg aaagttgata atgccctcca gtctggtaat       480
tcccaagagt ccgtcaccga acaagactca aaggactcta catacagtct gtcttctact       540
ctaacgttgt ctaaagctga ctacgaaaag cacaaggtgt atgcatgtga agttacgcat       600
caaggactgt cttctcccgt aacaaagtca ttcaacaggg gcgaatgt                    648

<210>  29
<211>  648
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  29
gatattcaaa tgacgcagtc cccgagctct ctgtcggcgt ctgtcggcga ccgtgtaacc        60
atcacttgcc gggcgtctca aggaatcagt tcctacctcg cctggtacca gcaaaaaccg       120
ggtaaagctc ctaagttgct tatttatgcc gcctcttcct tacagtctgg cgtaccctcg       180
cgattctctg gaagcggatc cggcacagac tttactctaa caatcagttc tctgcaaccg       240
gaggacttcg caacctacta ttgtcagacc tggtcgggat ggcctgacta tctcacgttt       300
ggtcaaggaa ctaaggtaga aataaaaagg acagtcgcag caccttcggt gtttatcttt       360
cctccgtcgg acgaacagtt aaagagtgga accgctagcg tggtctgtct tttgaataat       420
ttctacccga gggaagctaa agtccagtgg aaagtggaca acgcactcca atcgggtaat       480
tcacaagagt cagtgaccga acaggactct aaggactcaa catattccct ctcctcgact       540
ttgactttat ctaaagcaga ttatgagaaa cacaaggtgt atgcctgcga ggtgactcat       600
caaggtctct ctagccctgt taccaaaagt tttaacaggg gagagtgt                    648

<210>  30
<211>  453
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  30
Glu Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Thr 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Ala Ser Leu Ser 
            20                  25                  30          
Ala Val Gln Trp Val Arg Gln Ala Arg Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              
Gly Trp Ile Met Pro Gly Ser Gly Asn Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Glu Arg Val Thr Ile Thr Arg Asp Met Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Pro Tyr Cys Ser Thr Thr Leu Cys Asn Asp Gly Phe Asp Ile 
            100                 105                 110         
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             
Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 
Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 
Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     
Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         
Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             
Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 
Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         
Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
        355                 360                 365             
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             
Leu Ser Pro Gly Lys 
    450             

<210>  31
<211>  215
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  31
Asp Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Ser Asp Arg Phe Ser 
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  
Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ala Ser Ser Pro 
                85                  90                  95      
Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys 
    210                 215 

