SEQUENCE LISTING

<110> Cellectis S.A.; Albert-Ludwigs-Universität Freiburg

<120> GENE THERAPY FOR THE TREATMENT OF HYPER-IGE SYNDROME (HIES) BY TARGETED GENE INTEGRATION
<130> P243029DK00

<160> 78

<170> PatentIn version 3.5

<210>  1

<211>  770
<212>  PRT
<213>  homo sapiens

<220>
<223>  Full STAT3 polypeptide sequence

<400>  1
Met Ala Gln Trp Asn Gln Leu Gln Gln Leu Asp Thr Arg Tyr Leu Glu 
1               5                   10                  15      


Gln Leu His Gln Leu Tyr Ser Asp Ser Phe Pro Met Glu Leu Arg Gln 
            20                  25                  30          


Phe Leu Ala Pro Trp Ile Glu Ser Gln Asp Trp Ala Tyr Ala Ala Ser 
        35                  40                  45              


Lys Glu Ser His Ala Thr Leu Val Phe His Asn Leu Leu Gly Glu Ile 
    50                  55                  60                  


Asp Gln Gln Tyr Ser Arg Phe Leu Gln Glu Ser Asn Val Leu Tyr Gln 
65                  70                  75                  80  


His Asn Leu Arg Arg Ile Lys Gln Phe Leu Gln Ser Arg Tyr Leu Glu 
                85                  90                  95      


Lys Pro Met Glu Ile Ala Arg Ile Val Ala Arg Cys Leu Trp Glu Glu 
            100                 105                 110         


Ser Arg Leu Leu Gln Thr Ala Ala Thr Ala Ala Gln Gln Gly Gly Gln 
        115                 120                 125             


Ala Asn His Pro Thr Ala Ala Val Val Thr Glu Lys Gln Gln Met Leu 
    130                 135                 140                 


Glu Gln His Leu Gln Asp Val Arg Lys Arg Val Gln Asp Leu Glu Gln 
145                 150                 155                 160 


Lys Met Lys Val Val Glu Asn Leu Gln Asp Asp Phe Asp Phe Asn Tyr 
                165                 170                 175     


Lys Thr Leu Lys Ser Gln Gly Asp Met Gln Asp Leu Asn Gly Asn Asn 
            180                 185                 190         


Gln Ser Val Thr Arg Gln Lys Met Gln Gln Leu Glu Gln Met Leu Thr 
        195                 200                 205             


Ala Leu Asp Gln Met Arg Arg Ser Ile Val Ser Glu Leu Ala Gly Leu 
    210                 215                 220                 


Leu Ser Ala Met Glu Tyr Val Gln Lys Thr Leu Thr Asp Glu Glu Leu 
225                 230                 235                 240 


Ala Asp Trp Lys Arg Arg Gln Gln Ile Ala Cys Ile Gly Gly Pro Pro 
                245                 250                 255     


Asn Ile Cys Leu Asp Arg Leu Glu Asn Trp Ile Thr Ser Leu Ala Glu 
            260                 265                 270         


Ser Gln Leu Gln Thr Arg Gln Gln Ile Lys Lys Leu Glu Glu Leu Gln 
        275                 280                 285             


Gln Lys Val Ser Tyr Lys Gly Asp Pro Ile Val Gln His Arg Pro Met 
    290                 295                 300                 


Leu Glu Glu Arg Ile Val Glu Leu Phe Arg Asn Leu Met Lys Ser Ala 
305                 310                 315                 320 


Phe Val Val Glu Arg Gln Pro Cys Met Pro Met His Pro Asp Arg Pro 
                325                 330                 335     


Leu Val Ile Lys Thr Gly Val Gln Phe Thr Thr Lys Val Arg Leu Leu 
            340                 345                 350         


Val Lys Phe Pro Glu Leu Asn Tyr Gln Leu Lys Ile Lys Val Cys Ile 
        355                 360                 365             


Asp Lys Asp Ser Gly Asp Val Ala Ala Leu Arg Gly Ser Arg Lys Phe 
    370                 375                 380                 


Asn Ile Leu Gly Thr Asn Thr Lys Val Met Asn Met Glu Glu Ser Asn 
385                 390                 395                 400 


Asn Gly Ser Leu Ser Ala Glu Phe Lys His Leu Thr Leu Arg Glu Gln 
                405                 410                 415     


Arg Cys Gly Asn Gly Gly Arg Ala Asn Cys Asp Ala Ser Leu Ile Val 
            420                 425                 430         


Thr Glu Glu Leu His Leu Ile Thr Phe Glu Thr Glu Val Tyr His Gln 
        435                 440                 445             


Gly Leu Lys Ile Asp Leu Glu Thr His Ser Leu Pro Val Val Val Ile 
    450                 455                 460                 


Ser Asn Ile Cys Gln Met Pro Asn Ala Trp Ala Ser Ile Leu Trp Tyr 
465                 470                 475                 480 


Asn Met Leu Thr Asn Asn Pro Lys Asn Val Asn Phe Phe Thr Lys Pro 
                485                 490                 495     


Pro Ile Gly Thr Trp Asp Gln Val Ala Glu Val Leu Ser Trp Gln Phe 
            500                 505                 510         


Ser Ser Thr Thr Lys Arg Gly Leu Ser Ile Glu Gln Leu Thr Thr Leu 
        515                 520                 525             


Ala Glu Lys Leu Leu Gly Pro Gly Val Asn Tyr Ser Gly Cys Gln Ile 
    530                 535                 540                 


Thr Trp Ala Lys Phe Cys Lys Glu Asn Met Ala Gly Lys Gly Phe Ser 
545                 550                 555                 560 


Phe Trp Val Trp Leu Asp Asn Ile Ile Asp Leu Val Lys Lys Tyr Ile 
                565                 570                 575     


Leu Ala Leu Trp Asn Glu Gly Tyr Ile Met Gly Phe Ile Ser Lys Glu 
            580                 585                 590         


Arg Glu Arg Ala Ile Leu Ser Thr Lys Pro Pro Gly Thr Phe Leu Leu 
        595                 600                 605             


Arg Phe Ser Glu Ser Ser Lys Glu Gly Gly Val Thr Phe Thr Trp Val 
    610                 615                 620                 


Glu Lys Asp Ile Ser Gly Lys Thr Gln Ile Gln Ser Val Glu Pro Tyr 
625                 630                 635                 640 


Thr Lys Gln Gln Leu Asn Asn Met Ser Phe Ala Glu Ile Ile Met Gly 
                645                 650                 655     


Tyr Lys Ile Met Asp Ala Thr Asn Ile Leu Val Ser Pro Leu Val Tyr 
            660                 665                 670         


Leu Tyr Pro Asp Ile Pro Lys Glu Glu Ala Phe Gly Lys Tyr Cys Arg 
        675                 680                 685             


Pro Glu Ser Gln Glu His Pro Glu Ala Asp Pro Gly Ser Ala Ala Pro 
    690                 695                 700                 


Tyr Leu Lys Thr Lys Phe Ile Cys Val Thr Pro Thr Thr Cys Ser Asn 
705                 710                 715                 720 


Thr Ile Asp Leu Pro Met Ser Pro Arg Thr Leu Asp Ser Leu Met Gln 
                725                 730                 735     


Phe Gly Asn Asn Gly Glu Gly Ala Glu Pro Ser Ala Gly Gly Gln Phe 
            740                 745                 750         


Glu Ser Leu Thr Phe Asp Met Glu Leu Thr Ser Glu Cys Ala Thr Ser 
        755                 760                 765             


Pro Met 
    770 


<210>  2

<211>  51
<212>  PRT
<213>  homo sapiens

<220>
<223>  STAT3 polypeptide encoded by Exon 8

<400>  2
Ser Ile Val Ser Glu Leu Ala Gly Leu Leu Ser Ala Met Glu Tyr Val 
1               5                   10                  15      


Gln Lys Thr Leu Thr Asp Glu Glu Leu Ala Asp Trp Lys Arg Arg Gln 
            20                  25                  30          


Gln Ile Ala Cys Ile Gly Gly Pro Pro Asn Ile Cys Leu Asp Arg Leu 
        35                  40                  45              


Glu Asn Trp 
    50      


<210>  3

<211>  53
<212>  PRT
<213>  homo sapiens

<220>
<223>  STAT3 polypeptide encoded by Exon 9

<400>  3
Ile Thr Ser Leu Ala Glu Ser Gln Leu Gln Thr Arg Gln Gln Ile Lys 
1               5                   10                  15      


Lys Leu Glu Glu Leu Gln Gln Lys Val Ser Tyr Lys Gly Asp Pro Ile 
            20                  25                  30          


Val Gln His Arg Pro Met Leu Glu Glu Arg Ile Val Glu Leu Phe Arg 
        35                  40                  45              


Asn Leu Met Lys Ser 
    50              


<210>  4

<211>  31
<212>  PRT
<213>  homo sapiens

<220>
<223>  STAT3 polypeptide encoded by Exon 10

<400>  4
Ala Phe Val Val Glu Arg Gln Pro Cys Met Pro Met His Pro Asp Arg 
1               5                   10                  15      


Pro Leu Val Ile Lys Thr Gly Val Gln Phe Thr Thr Lys Val Arg 
            20                  25                  30      


<210>  5

<211>  20
<212>  PRT
<213>  homo sapiens

<220>
<223>  STAT3 polypeptide encoded by Exon 11

<400>  5
Leu Leu Val Lys Phe Pro Glu Leu Asn Tyr Gln Leu Lys Ile Lys Val 
1               5                   10                  15      


Cys Ile Asp Lys 
            20  


<210>  6

<211>  10
<212>  PRT
<213>  homo sapiens

<220>
<223>  STAT3 polypeptide encoded by Exon 12

<400>  6
Asp Ser Gly Asp Val Ala Ala Leu Arg Gly 
1               5                   10  


<210>  7

<211>  31
<212>  PRT
<213>  homo sapiens

<220>
<223>  STAT3 polypeptide encoded by Exon 13

<400>  7
Ser Arg Lys Phe Asn Ile Leu Gly Thr Asn Thr Lys Val Met Asn Met 
1               5                   10                  15      


Glu Glu Ser Asn Asn Gly Ser Leu Ser Ala Glu Phe Lys His Leu 
            20                  25                  30      


<210>  8

<211>  16
<212>  PRT
<213>  homo sapiens

<220>
<223>  STAT3 polypeptide encoded by Exon 14

<400>  8
Thr Leu Arg Glu Gln Arg Cys Gly Asn Gly Gly Arg Ala Asn Cys Asp 
1               5                   10                  15      


<210>  9

<211>  28
<212>  PRT
<213>  homo sapiens

<220>
<223>  STAT3 polypeptide encoded by Exon 15

<400>  9
Ala Ser Leu Ile Val Thr Glu Glu Leu His Leu Ile Thr Phe Glu Thr 
1               5                   10                  15      


Glu Val Tyr His Gln Gly Leu Lys Ile Asp Leu Glu 
            20                  25              


<210>  10

<211>  33
<212>  PRT
<213>  homo sapiens

<220>
<223>  STAT3 polypeptide encoded by Exon 16

<400>  10
Thr His Ser Leu Pro Val Val Val Ile Ser Asn Ile Cys Gln Met Pro 
1               5                   10                  15      


Asn Ala Trp Ala Ser Ile Leu Trp Tyr Asn Met Leu Thr Asn Asn Pro 
            20                  25                  30          


Lys 
    


<210>  11

<211>  45
<212>  PRT
<213>  homo sapiens

<220>
<223>  STAT3 polypeptide encoded by Exon 17

<400>  11
Asn Val Asn Phe Phe Thr Lys Pro Pro Ile Gly Thr Trp Asp Gln Val 
1               5                   10                  15      


Ala Glu Val Leu Ser Trp Gln Phe Ser Ser Thr Thr Lys Arg Gly Leu 
            20                  25                  30          


Ser Ile Glu Gln Leu Thr Thr Leu Ala Glu Lys Leu Leu 
        35                  40                  45  


<210>  12

<211>  17
<212>  PRT
<213>  homo sapiens

<220>
<223>  STAT3 polypeptide encoded by Exon 18

<400>  12
Pro Gly Val Asn Tyr Ser Gly Cys Gln Ile Thr Trp Ala Lys Phe Cys 
1               5                   10                  15      


Lys 
    


<210>  13

<211>  32
<212>  PRT
<213>  homo sapiens

<220>
<223>  STAT3 polypeptide encoded by Exon 19

<400>  13
Glu Asn Met Ala Gly Lys Gly Phe Ser Phe Trp Val Trp Leu Asp Asn 
1               5                   10                  15      


Ile Ile Asp Leu Val Lys Lys Tyr Ile Leu Ala Leu Trp Asn Glu Gly 
            20                  25                  30          


<210>  14

<211>  47
<212>  PRT
<213>  homo sapiens

<220>
<223>  STAT3 polypeptide encoded by Exon 20

<400>  14
Tyr Ile Met Gly Phe Ile Ser Lys Glu Arg Glu Arg Ala Ile Leu Ser 
1               5                   10                  15      


Thr Lys Pro Pro Gly Thr Phe Leu Leu Arg Phe Ser Glu Ser Ser Lys 
            20                  25                  30          


Glu Gly Gly Val Thr Phe Thr Trp Val Glu Lys Asp Ile Ser Gly 
        35                  40                  45          


<210>  15

<211>  71
<212>  PRT
<213>  homo sapiens

<220>
<223>  STAT3 polypeptide encoded by Exon 21

<400>  15
Lys Thr Gln Ile Gln Ser Val Glu Pro Tyr Thr Lys Gln Gln Leu Asn 
1               5                   10                  15      


Asn Met Ser Phe Ala Glu Ile Ile Met Gly Tyr Lys Ile Met Asp Ala 
            20                  25                  30          


Thr Asn Ile Leu Val Ser Pro Leu Val Tyr Leu Tyr Pro Asp Ile Pro 
        35                  40                  45              


Lys Glu Glu Ala Phe Gly Lys Tyr Cys Arg Pro Glu Ser Gln Glu His 
    50                  55                  60                  


Pro Glu Ala Asp Pro Gly Ser 
65                  70      


<210>  16

<211>  14
<212>  PRT
<213>  homo sapiens

<220>
<223>  STAT3 polypeptide encoded by Exon 22

<400>  16
Ala Ala Pro Tyr Leu Lys Thr Lys Phe Ile Cys Val Thr Pro 
1               5                   10                  


<210>  17

<211>  38
<212>  PRT
<213>  homo sapiens

<220>
<223>  STAT3 polypeptide encoded by Exon 23

<400>  17
Thr Thr Cys Ser Asn Thr Ile Asp Leu Pro Met Ser Pro Arg Thr Leu 
1               5                   10                  15      


Asp Ser Leu Met Gln Phe Gly Asn Asn Gly Glu Gly Ala Glu Pro Ser 
            20                  25                  30          


Ala Gly Gly Gln Phe Glu 
        35              


<210>  18

<211>  17
<212>  PRT
<213>  homo sapiens

<220>
<223>  STAT3 polypeptide encoded by Exon 24

<400>  18
Ser Leu Thr Phe Asp Met Glu Leu Thr Ser Glu Cys Ala Thr Ser Pro 
1               5                   10                  15      


Met 
    


<210>  19

<211>  770
<212>  PRT
<213>  homo sapiens

<220>
<223>  STAT3alpha isoform

<400>  19
Met Ala Gln Trp Asn Gln Leu Gln Gln Leu Asp Thr Arg Tyr Leu Glu 
1               5                   10                  15      


Gln Leu His Gln Leu Tyr Ser Asp Ser Phe Pro Met Glu Leu Arg Gln 
            20                  25                  30          


Phe Leu Ala Pro Trp Ile Glu Ser Gln Asp Trp Ala Tyr Ala Ala Ser 
        35                  40                  45              


Lys Glu Ser His Ala Thr Leu Val Phe His Asn Leu Leu Gly Glu Ile 
    50                  55                  60                  


Asp Gln Gln Tyr Ser Arg Phe Leu Gln Glu Ser Asn Val Leu Tyr Gln 
65                  70                  75                  80  


His Asn Leu Arg Arg Ile Lys Gln Phe Leu Gln Ser Arg Tyr Leu Glu 
                85                  90                  95      


Lys Pro Met Glu Ile Ala Arg Ile Val Ala Arg Cys Leu Trp Glu Glu 
            100                 105                 110         


Ser Arg Leu Leu Gln Thr Ala Ala Thr Ala Ala Gln Gln Gly Gly Gln 
        115                 120                 125             


Ala Asn His Pro Thr Ala Ala Val Val Thr Glu Lys Gln Gln Met Leu 
    130                 135                 140                 


Glu Gln His Leu Gln Asp Val Arg Lys Arg Val Gln Asp Leu Glu Gln 
145                 150                 155                 160 


Lys Met Lys Val Val Glu Asn Leu Gln Asp Asp Phe Asp Phe Asn Tyr 
                165                 170                 175     


Lys Thr Leu Lys Ser Gln Gly Asp Met Gln Asp Leu Asn Gly Asn Asn 
            180                 185                 190         


Gln Ser Val Thr Arg Gln Lys Met Gln Gln Leu Glu Gln Met Leu Thr 
        195                 200                 205             


Ala Leu Asp Gln Met Arg Arg Ser Ile Val Ser Glu Leu Ala Gly Leu 
    210                 215                 220                 


Leu Ser Ala Met Glu Tyr Val Gln Lys Thr Leu Thr Asp Glu Glu Leu 
225                 230                 235                 240 


Ala Asp Trp Lys Arg Arg Gln Gln Ile Ala Cys Ile Gly Gly Pro Pro 
                245                 250                 255     


Asn Ile Cys Leu Asp Arg Leu Glu Asn Trp Ile Thr Ser Leu Ala Glu 
            260                 265                 270         


Ser Gln Leu Gln Thr Arg Gln Gln Ile Lys Lys Leu Glu Glu Leu Gln 
        275                 280                 285             


Gln Lys Val Ser Tyr Lys Gly Asp Pro Ile Val Gln His Arg Pro Met 
    290                 295                 300                 


Leu Glu Glu Arg Ile Val Glu Leu Phe Arg Asn Leu Met Lys Ser Ala 
305                 310                 315                 320 


Phe Val Val Glu Arg Gln Pro Cys Met Pro Met His Pro Asp Arg Pro 
                325                 330                 335     


Leu Val Ile Lys Thr Gly Val Gln Phe Thr Thr Lys Val Arg Leu Leu 
            340                 345                 350         


Val Lys Phe Pro Glu Leu Asn Tyr Gln Leu Lys Ile Lys Val Cys Ile 
        355                 360                 365             


Asp Lys Asp Ser Gly Asp Val Ala Ala Leu Arg Gly Ser Arg Lys Phe 
    370                 375                 380                 


Asn Ile Leu Gly Thr Asn Thr Lys Val Met Asn Met Glu Glu Ser Asn 
385                 390                 395                 400 


Asn Gly Ser Leu Ser Ala Glu Phe Lys His Leu Thr Leu Arg Glu Gln 
                405                 410                 415     


Arg Cys Gly Asn Gly Gly Arg Ala Asn Cys Asp Ala Ser Leu Ile Val 
            420                 425                 430         


Thr Glu Glu Leu His Leu Ile Thr Phe Glu Thr Glu Val Tyr His Gln 
        435                 440                 445             


Gly Leu Lys Ile Asp Leu Glu Thr His Ser Leu Pro Val Val Val Ile 
    450                 455                 460                 


Ser Asn Ile Cys Gln Met Pro Asn Ala Trp Ala Ser Ile Leu Trp Tyr 
465                 470                 475                 480 


Asn Met Leu Thr Asn Asn Pro Lys Asn Val Asn Phe Phe Thr Lys Pro 
                485                 490                 495     


Pro Ile Gly Thr Trp Asp Gln Val Ala Glu Val Leu Ser Trp Gln Phe 
            500                 505                 510         


Ser Ser Thr Thr Lys Arg Gly Leu Ser Ile Glu Gln Leu Thr Thr Leu 
        515                 520                 525             


Ala Glu Lys Leu Leu Gly Pro Gly Val Asn Tyr Ser Gly Cys Gln Ile 
    530                 535                 540                 


Thr Trp Ala Lys Phe Cys Lys Glu Asn Met Ala Gly Lys Gly Phe Ser 
545                 550                 555                 560 


Phe Trp Val Trp Leu Asp Asn Ile Ile Asp Leu Val Lys Lys Tyr Ile 
                565                 570                 575     


Leu Ala Leu Trp Asn Glu Gly Tyr Ile Met Gly Phe Ile Ser Lys Glu 
            580                 585                 590         


Arg Glu Arg Ala Ile Leu Ser Thr Lys Pro Pro Gly Thr Phe Leu Leu 
        595                 600                 605             


Arg Phe Ser Glu Ser Ser Lys Glu Gly Gly Val Thr Phe Thr Trp Val 
    610                 615                 620                 


Glu Lys Asp Ile Ser Gly Lys Thr Gln Ile Gln Ser Val Glu Pro Tyr 
625                 630                 635                 640 


Thr Lys Gln Gln Leu Asn Asn Met Ser Phe Ala Glu Ile Ile Met Gly 
                645                 650                 655     


Tyr Lys Ile Met Asp Ala Thr Asn Ile Leu Val Ser Pro Leu Val Tyr 
            660                 665                 670         


Leu Tyr Pro Asp Ile Pro Lys Glu Glu Ala Phe Gly Lys Tyr Cys Arg 
        675                 680                 685             


Pro Glu Ser Gln Glu His Pro Glu Ala Asp Pro Gly Ser Ala Ala Pro 
    690                 695                 700                 


Tyr Leu Lys Thr Lys Phe Ile Cys Val Thr Pro Thr Thr Cys Ser Asn 
705                 710                 715                 720 


Thr Ile Asp Leu Pro Met Ser Pro Arg Thr Leu Asp Ser Leu Met Gln 
                725                 730                 735     


Phe Gly Asn Asn Gly Glu Gly Ala Glu Pro Ser Ala Gly Gly Gln Phe 
            740                 745                 750         


Glu Ser Leu Thr Phe Asp Met Glu Leu Thr Ser Glu Cys Ala Thr Ser 
        755                 760                 765             


Pro Met 
    770 


<210>  20

<211>  721
<212>  PRT
<213>  homo sapiens

<220>
<223>  STAT3beta isoform

<400>  20
Met Ala Gln Trp Asn Gln Leu Gln Gln Leu Asp Thr Arg Tyr Leu Glu 
1               5                   10                  15      


Gln Leu His Gln Leu Tyr Ser Asp Ser Phe Pro Met Glu Leu Arg Gln 
            20                  25                  30          


Phe Leu Ala Pro Trp Ile Glu Ser Gln Asp Trp Ala Tyr Ala Ala Ser 
        35                  40                  45              


Lys Glu Ser His Ala Thr Leu Val Phe His Asn Leu Leu Gly Glu Ile 
    50                  55                  60                  


Asp Gln Gln Tyr Ser Arg Phe Leu Gln Glu Ser Asn Val Leu Tyr Gln 
65                  70                  75                  80  


His Asn Leu Arg Arg Ile Lys Gln Phe Leu Gln Ser Arg Tyr Leu Glu 
                85                  90                  95      


Lys Pro Met Glu Ile Ala Arg Ile Val Ala Arg Cys Leu Trp Glu Glu 
            100                 105                 110         


Ser Arg Leu Leu Gln Thr Ala Ala Thr Ala Ala Gln Gln Gly Gly Gln 
        115                 120                 125             


Ala Asn His Pro Thr Ala Ala Val Val Thr Glu Lys Gln Gln Met Leu 
    130                 135                 140                 


Glu Gln His Leu Gln Asp Val Arg Lys Arg Val Gln Asp Leu Glu Gln 
145                 150                 155                 160 


Lys Met Lys Val Val Glu Asn Leu Gln Asp Asp Phe Asp Phe Asn Tyr 
                165                 170                 175     


Lys Thr Leu Lys Ser Gln Gly Asp Met Gln Asp Leu Asn Gly Asn Asn 
            180                 185                 190         


Gln Ser Val Thr Arg Gln Lys Met Gln Gln Leu Glu Gln Met Leu Thr 
        195                 200                 205             


Ala Leu Asp Gln Met Arg Arg Ser Ile Val Ser Glu Leu Ala Gly Leu 
    210                 215                 220                 


Leu Ser Ala Met Glu Tyr Val Gln Lys Thr Leu Thr Asp Glu Glu Leu 
225                 230                 235                 240 


Ala Asp Trp Lys Arg Arg Gln Gln Ile Ala Cys Ile Gly Gly Pro Pro 
                245                 250                 255     


Asn Ile Cys Leu Asp Arg Leu Glu Asn Trp Ile Thr Ser Leu Ala Glu 
            260                 265                 270         


Ser Gln Leu Gln Thr Arg Gln Gln Ile Lys Lys Leu Glu Glu Leu Gln 
        275                 280                 285             


Gln Lys Val Ser Tyr Lys Gly Asp Pro Ile Val Gln His Arg Pro Met 
    290                 295                 300                 


Leu Glu Glu Arg Ile Val Glu Leu Phe Arg Asn Leu Met Lys Ser Ala 
305                 310                 315                 320 


Phe Val Val Glu Arg Gln Pro Cys Met Pro Met His Pro Asp Arg Pro 
                325                 330                 335     


Leu Val Ile Lys Thr Gly Val Gln Phe Thr Thr Lys Val Arg Leu Leu 
            340                 345                 350         


Val Lys Phe Pro Glu Leu Asn Tyr Gln Leu Lys Ile Lys Val Cys Ile 
        355                 360                 365             


Asp Lys Asp Ser Gly Asp Val Ala Ala Leu Arg Gly Ser Arg Lys Phe 
    370                 375                 380                 


Asn Ile Leu Gly Thr Asn Thr Lys Val Met Asn Met Glu Glu Ser Asn 
385                 390                 395                 400 


Asn Gly Ser Leu Ser Ala Glu Phe Lys His Leu Thr Leu Arg Glu Gln 
                405                 410                 415     


Arg Cys Gly Asn Gly Gly Arg Ala Asn Cys Asp Ala Ser Leu Ile Val 
            420                 425                 430         


Thr Glu Glu Leu His Leu Ile Thr Phe Glu Thr Glu Val Tyr His Gln 
        435                 440                 445             


Gly Leu Lys Ile Asp Leu Glu Thr His Ser Leu Pro Val Val Val Ile 
    450                 455                 460                 


Ser Asn Ile Cys Gln Met Pro Asn Ala Trp Ala Ser Ile Leu Trp Tyr 
465                 470                 475                 480 


Asn Met Leu Thr Asn Asn Pro Lys Asn Val Asn Phe Phe Thr Lys Pro 
                485                 490                 495     


Pro Ile Gly Thr Trp Asp Gln Val Ala Glu Val Leu Ser Trp Gln Phe 
            500                 505                 510         


Ser Ser Thr Thr Lys Arg Gly Leu Ser Ile Glu Gln Leu Thr Thr Leu 
        515                 520                 525             


Ala Glu Lys Leu Leu Gly Pro Gly Val Asn Tyr Ser Gly Cys Gln Ile 
    530                 535                 540                 


Thr Trp Ala Lys Phe Cys Lys Glu Asn Met Ala Gly Lys Gly Phe Ser 
545                 550                 555                 560 


Phe Trp Val Trp Leu Asp Asn Ile Ile Asp Leu Val Lys Lys Tyr Ile 
                565                 570                 575     


Leu Ala Leu Trp Asn Glu Gly Tyr Ile Met Gly Phe Ile Ser Lys Glu 
            580                 585                 590         


Arg Glu Arg Ala Ile Leu Ser Thr Lys Pro Pro Gly Thr Phe Leu Leu 
        595                 600                 605             


Arg Phe Ser Glu Ser Ser Lys Glu Gly Gly Val Thr Phe Thr Trp Val 
    610                 615                 620                 


Glu Lys Asp Ile Ser Gly Lys Thr Gln Ile Gln Ser Val Glu Pro Tyr 
625                 630                 635                 640 


Thr Lys Gln Gln Leu Asn Asn Met Ser Phe Ala Glu Ile Ile Met Gly 
                645                 650                 655     


Tyr Lys Ile Met Asp Ala Thr Asn Ile Leu Val Ser Pro Leu Val Tyr 
            660                 665                 670         


Leu Tyr Pro Asp Ile Pro Lys Glu Glu Ala Phe Gly Lys Tyr Cys Arg 
        675                 680                 685             


Pro Glu Ser Gln Glu His Pro Glu Ala Asp Pro Gly Ala Ala Pro Tyr 
    690                 695                 700                 


Leu Lys Thr Lys Phe Ile Cys Val Thr Pro Phe Ile Asp Ala Val Trp 
705                 710                 715                 720 


Lys 
    


<210>  21

<211>  925
<212>  PRT
<213>  artificial

<220>
<223>  TALEN i7 Left monomer

<400>  21
Met Gly Asp Pro Lys Lys Lys Arg Lys Val Ile Asp Ile Ala Asp Leu 
1               5                   10                  15      


Arg Thr Leu Gly Tyr Ser Gln Gln Gln Gln Glu Lys Ile Lys Pro Lys 
            20                  25                  30          


Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu Val Gly His Gly 
        35                  40                  45              


Phe Thr His Ala His Ile Val Ala Leu Ser Gln His Pro Ala Ala Leu 
    50                  55                  60                  


Gly Thr Val Ala Val Lys Tyr Gln Asp Met Ile Ala Ala Leu Pro Glu 
65                  70                  75                  80  


Ala Thr His Glu Ala Ile Val Gly Val Gly Lys Gln Trp Ser Gly Ala 
                85                  90                  95      


Arg Ala Leu Glu Ala Leu Leu Thr Val Ala Gly Glu Leu Arg Gly Pro 
            100                 105                 110         


Pro Leu Gln Leu Asp Thr Gly Gln Leu Leu Lys Ile Ala Lys Arg Gly 
        115                 120                 125             


Gly Val Thr Ala Val Glu Ala Val His Ala Trp Arg Asn Ala Leu Thr 
    130                 135                 140                 


Gly Ala Pro Leu Asn Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser 
145                 150                 155                 160 


His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
                165                 170                 175     


Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile 
            180                 185                 190         


Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
        195                 200                 205             


Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val 
    210                 215                 220                 


Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
225                 230                 235                 240 


Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln 
                245                 250                 255     


Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr 
            260                 265                 270         


Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro 
        275                 280                 285             


Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu 
    290                 295                 300                 


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu 
305                 310                 315                 320 


Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln 
                325                 330                 335     


Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His 
            340                 345                 350         


Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly 
        355                 360                 365             


Lys Gln Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln 
    370                 375                 380                 


Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn 
385                 390                 395                 400 


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu 
                405                 410                 415     


Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser 
            420                 425                 430         


Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
        435                 440                 445             


Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile 
    450                 455                 460                 


Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
465                 470                 475                 480 


Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val 
                485                 490                 495     


Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
            500                 505                 510         


Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln 
        515                 520                 525             


Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr 
    530                 535                 540                 


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro 
545                 550                 555                 560 


Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu 
                565                 570                 575     


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu 
            580                 585                 590         


Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln 
        595                 600                 605             


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His 
    610                 615                 620                 


Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly 
625                 630                 635                 640 


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
                645                 650                 655     


Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly 
            660                 665                 670         


Gly Gly Arg Pro Ala Leu Glu Ser Ile Val Ala Gln Leu Ser Arg Pro 
        675                 680                 685             


Asp Pro Ala Leu Ala Ala Leu Thr Asn Asp His Leu Val Ala Leu Ala 
    690                 695                 700                 


Cys Leu Gly Gly Arg Pro Ala Leu Asp Ala Val Lys Lys Gly Leu Gly 
705                 710                 715                 720 


Asp Pro Ile Ser Arg Ser Gln Leu Val Lys Ser Glu Leu Glu Glu Lys 
                725                 730                 735     


Lys Ser Glu Leu Arg His Lys Leu Lys Tyr Val Pro His Glu Tyr Ile 
            740                 745                 750         


Glu Leu Ile Glu Ile Ala Arg Asn Ser Thr Gln Asp Arg Ile Leu Glu 
        755                 760                 765             


Met Lys Val Met Glu Phe Phe Met Lys Val Tyr Gly Tyr Arg Gly Lys 
    770                 775                 780                 


His Leu Gly Gly Ser Arg Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly 
785                 790                 795                 800 


Ser Pro Ile Asp Tyr Gly Val Ile Val Asp Thr Lys Ala Tyr Ser Gly 
                805                 810                 815     


Gly Tyr Asn Leu Pro Ile Gly Gln Ala Asp Glu Met Gln Arg Tyr Val 
            820                 825                 830         


Glu Glu Asn Gln Thr Arg Asn Lys His Ile Asn Pro Asn Glu Trp Trp 
        835                 840                 845             


Lys Val Tyr Pro Ser Ser Val Thr Glu Phe Lys Phe Leu Phe Val Ser 
    850                 855                 860                 


Gly His Phe Lys Gly Asn Tyr Lys Ala Gln Leu Thr Arg Leu Asn His 
865                 870                 875                 880 


Ile Thr Asn Cys Asn Gly Ala Val Leu Ser Val Glu Glu Leu Leu Ile 
                885                 890                 895     


Gly Gly Glu Met Ile Lys Ala Gly Thr Leu Thr Leu Glu Glu Val Arg 
            900                 905                 910         


Arg Lys Phe Asn Asn Gly Glu Ile Asn Phe Ala Ala Asp 
        915                 920                 925 


<210>  22

<211>  925
<212>  PRT
<213>  artificial

<220>
<223>  TALEN i7 right monomer

<400>  22
Met Gly Asp Pro Lys Lys Lys Arg Lys Val Ile Asp Ile Ala Asp Leu 
1               5                   10                  15      


Arg Thr Leu Gly Tyr Ser Gln Gln Gln Gln Glu Lys Ile Lys Pro Lys 
            20                  25                  30          


Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu Val Gly His Gly 
        35                  40                  45              


Phe Thr His Ala His Ile Val Ala Leu Ser Gln His Pro Ala Ala Leu 
    50                  55                  60                  


Gly Thr Val Ala Val Lys Tyr Gln Asp Met Ile Ala Ala Leu Pro Glu 
65                  70                  75                  80  


Ala Thr His Glu Ala Ile Val Gly Val Gly Lys Gln Trp Ser Gly Ala 
                85                  90                  95      


Arg Ala Leu Glu Ala Leu Leu Thr Val Ala Gly Glu Leu Arg Gly Pro 
            100                 105                 110         


Pro Leu Gln Leu Asp Thr Gly Gln Leu Leu Lys Ile Ala Lys Arg Gly 
        115                 120                 125             


Gly Val Thr Ala Val Glu Ala Val His Ala Trp Arg Asn Ala Leu Thr 
    130                 135                 140                 


Gly Ala Pro Leu Asn Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser 
145                 150                 155                 160 


Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
                165                 170                 175     


Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile 
            180                 185                 190         


Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
        195                 200                 205             


Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val 
    210                 215                 220                 


Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
225                 230                 235                 240 


Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln 
                245                 250                 255     


Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr 
            260                 265                 270         


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro 
        275                 280                 285             


Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu 
    290                 295                 300                 


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu 
305                 310                 315                 320 


Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln 
                325                 330                 335     


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His 
            340                 345                 350         


Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly 
        355                 360                 365             


Lys Gln Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln 
    370                 375                 380                 


Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile 
385                 390                 395                 400 


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val Leu 
                405                 410                 415     


Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser 
            420                 425                 430         


His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
        435                 440                 445             


Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile 
    450                 455                 460                 


Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
465                 470                 475                 480 


Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val 
                485                 490                 495     


Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
            500                 505                 510         


Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln 
        515                 520                 525             


Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr 
    530                 535                 540                 


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro 
545                 550                 555                 560 


Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu 
                565                 570                 575     


Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu 
            580                 585                 590         


Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln 
        595                 600                 605             


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His 
    610                 615                 620                 


Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly 
625                 630                 635                 640 


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
                645                 650                 655     


Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly 
            660                 665                 670         


Gly Gly Arg Pro Ala Leu Glu Ser Ile Val Ala Gln Leu Ser Arg Pro 
        675                 680                 685             


Asp Pro Ala Leu Ala Ala Leu Thr Asn Asp His Leu Val Ala Leu Ala 
    690                 695                 700                 


Cys Leu Gly Gly Arg Pro Ala Leu Asp Ala Val Lys Lys Gly Leu Gly 
705                 710                 715                 720 


Asp Pro Ile Ser Arg Ser Gln Leu Val Lys Ser Glu Leu Glu Glu Lys 
                725                 730                 735     


Lys Ser Glu Leu Arg His Lys Leu Lys Tyr Val Pro His Glu Tyr Ile 
            740                 745                 750         


Glu Leu Ile Glu Ile Ala Arg Asn Ser Thr Gln Asp Arg Ile Leu Glu 
        755                 760                 765             


Met Lys Val Met Glu Phe Phe Met Lys Val Tyr Gly Tyr Arg Gly Lys 
    770                 775                 780                 


His Leu Gly Gly Ser Arg Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly 
785                 790                 795                 800 


Ser Pro Ile Asp Tyr Gly Val Ile Val Asp Thr Lys Ala Tyr Ser Gly 
                805                 810                 815     


Gly Tyr Asn Leu Pro Ile Gly Gln Ala Asp Glu Met Gln Arg Tyr Val 
            820                 825                 830         


Glu Glu Asn Gln Thr Arg Asn Lys His Ile Asn Pro Asn Glu Trp Trp 
        835                 840                 845             


Lys Val Tyr Pro Ser Ser Val Thr Glu Phe Lys Phe Leu Phe Val Ser 
    850                 855                 860                 


Gly His Phe Lys Gly Asn Tyr Lys Ala Gln Leu Thr Arg Leu Asn His 
865                 870                 875                 880 


Ile Thr Asn Cys Asn Gly Ala Val Leu Ser Val Glu Glu Leu Leu Ile 
                885                 890                 895     


Gly Gly Glu Met Ile Lys Ala Gly Thr Leu Thr Leu Glu Glu Val Arg 
            900                 905                 910         


Arg Lys Phe Asn Asn Gly Glu Ile Asn Phe Ala Ala Asp 
        915                 920                 925 


<210>  23

<211>  925
<212>  PRT
<213>  artificial

<220>
<223>  TALEN i8b Left monomer

<400>  23
Met Gly Asp Pro Lys Lys Lys Arg Lys Val Ile Asp Ile Ala Asp Leu 
1               5                   10                  15      


Arg Thr Leu Gly Tyr Ser Gln Gln Gln Gln Glu Lys Ile Lys Pro Lys 
            20                  25                  30          


Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu Val Gly His Gly 
        35                  40                  45              


Phe Thr His Ala His Ile Val Ala Leu Ser Gln His Pro Ala Ala Leu 
    50                  55                  60                  


Gly Thr Val Ala Val Lys Tyr Gln Asp Met Ile Ala Ala Leu Pro Glu 
65                  70                  75                  80  


Ala Thr His Glu Ala Ile Val Gly Val Gly Lys Gln Trp Ser Gly Ala 
                85                  90                  95      


Arg Ala Leu Glu Ala Leu Leu Thr Val Ala Gly Glu Leu Arg Gly Pro 
            100                 105                 110         


Pro Leu Gln Leu Asp Thr Gly Gln Leu Leu Lys Ile Ala Lys Arg Gly 
        115                 120                 125             


Gly Val Thr Ala Val Glu Ala Val His Ala Trp Arg Asn Ala Leu Thr 
    130                 135                 140                 


Gly Ala Pro Leu Asn Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser 
145                 150                 155                 160 


Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Ala Leu Leu Pro 
                165                 170                 175     


Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile 
            180                 185                 190         


Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
        195                 200                 205             


Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val 
    210                 215                 220                 


Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
225                 230                 235                 240 


Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln 
                245                 250                 255     


Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr 
            260                 265                 270         


Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro 
        275                 280                 285             


Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu 
    290                 295                 300                 


Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu 
305                 310                 315                 320 


Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln 
                325                 330                 335     


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His 
            340                 345                 350         


Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly 
        355                 360                 365             


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
    370                 375                 380                 


Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly 
385                 390                 395                 400 


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu 
                405                 410                 415     


Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser 
            420                 425                 430         


Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
        435                 440                 445             


Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile 
    450                 455                 460                 


Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Ala Leu 
465                 470                 475                 480 


Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val 
                485                 490                 495     


Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
            500                 505                 510         


Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln 
        515                 520                 525             


Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr 
    530                 535                 540                 


Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro 
545                 550                 555                 560 


Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu 
                565                 570                 575     


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu 
            580                 585                 590         


Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln 
        595                 600                 605             


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His 
    610                 615                 620                 


Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly 
625                 630                 635                 640 


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
                645                 650                 655     


Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly 
            660                 665                 670         


Gly Gly Arg Pro Ala Leu Glu Ser Ile Val Ala Gln Leu Ser Arg Pro 
        675                 680                 685             


Asp Pro Ala Leu Ala Ala Leu Thr Asn Asp His Leu Val Ala Leu Ala 
    690                 695                 700                 


Cys Leu Gly Gly Arg Pro Ala Leu Asp Ala Val Lys Lys Gly Leu Gly 
705                 710                 715                 720 


Asp Pro Ile Ser Arg Ser Gln Leu Val Lys Ser Glu Leu Glu Glu Lys 
                725                 730                 735     


Lys Ser Glu Leu Arg His Lys Leu Lys Tyr Val Pro His Glu Tyr Ile 
            740                 745                 750         


Glu Leu Ile Glu Ile Ala Arg Asn Ser Thr Gln Asp Arg Ile Leu Glu 
        755                 760                 765             


Met Lys Val Met Glu Phe Phe Met Lys Val Tyr Gly Tyr Arg Gly Lys 
    770                 775                 780                 


His Leu Gly Gly Ser Arg Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly 
785                 790                 795                 800 


Ser Pro Ile Asp Tyr Gly Val Ile Val Asp Thr Lys Ala Tyr Ser Gly 
                805                 810                 815     


Gly Tyr Asn Leu Pro Ile Gly Gln Ala Asp Glu Met Gln Arg Tyr Val 
            820                 825                 830         


Glu Glu Asn Gln Thr Arg Asn Lys His Ile Asn Pro Asn Glu Trp Trp 
        835                 840                 845             


Lys Val Tyr Pro Ser Ser Val Thr Glu Phe Lys Phe Leu Phe Val Ser 
    850                 855                 860                 


Gly His Phe Lys Gly Asn Tyr Lys Ala Gln Leu Thr Arg Leu Asn His 
865                 870                 875                 880 


Ile Thr Asn Cys Asn Gly Ala Val Leu Ser Val Glu Glu Leu Leu Ile 
                885                 890                 895     


Gly Gly Glu Met Ile Lys Ala Gly Thr Leu Thr Leu Glu Glu Val Arg 
            900                 905                 910         


Arg Lys Phe Asn Asn Gly Glu Ile Asn Phe Ala Ala Asp 
        915                 920                 925 


<210>  24

<211>  925
<212>  PRT
<213>  artificial

<220>
<223>  TALEN i8b right monomer

<400>  24
Met Gly Asp Pro Lys Lys Lys Arg Lys Val Ile Asp Ile Ala Asp Leu 
1               5                   10                  15      


Arg Thr Leu Gly Tyr Ser Gln Gln Gln Gln Glu Lys Ile Lys Pro Lys 
            20                  25                  30          


Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu Val Gly His Gly 
        35                  40                  45              


Phe Thr His Ala His Ile Val Ala Leu Ser Gln His Pro Ala Ala Leu 
    50                  55                  60                  


Gly Thr Val Ala Val Lys Tyr Gln Asp Met Ile Ala Ala Leu Pro Glu 
65                  70                  75                  80  


Ala Thr His Glu Ala Ile Val Gly Val Gly Lys Gln Trp Ser Gly Ala 
                85                  90                  95      


Arg Ala Leu Glu Ala Leu Leu Thr Val Ala Gly Glu Leu Arg Gly Pro 
            100                 105                 110         


Pro Leu Gln Leu Asp Thr Gly Gln Leu Leu Lys Ile Ala Lys Arg Gly 
        115                 120                 125             


Gly Val Thr Ala Val Glu Ala Val His Ala Trp Arg Asn Ala Leu Thr 
    130                 135                 140                 


Gly Ala Pro Leu Asn Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser 
145                 150                 155                 160 


Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
                165                 170                 175     


Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile 
            180                 185                 190         


Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
        195                 200                 205             


Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val 
    210                 215                 220                 


Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
225                 230                 235                 240 


Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln 
                245                 250                 255     


Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr 
            260                 265                 270         


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro 
        275                 280                 285             


Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu 
    290                 295                 300                 


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu 
305                 310                 315                 320 


Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln 
                325                 330                 335     


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His 
            340                 345                 350         


Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly 
        355                 360                 365             


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
    370                 375                 380                 


Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile 
385                 390                 395                 400 


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val Leu 
                405                 410                 415     


Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser 
            420                 425                 430         


His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
        435                 440                 445             


Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile 
    450                 455                 460                 


Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
465                 470                 475                 480 


Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val 
                485                 490                 495     


Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
            500                 505                 510         


Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln 
        515                 520                 525             


Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr 
    530                 535                 540                 


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro 
545                 550                 555                 560 


Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu 
                565                 570                 575     


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu 
            580                 585                 590         


Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln 
        595                 600                 605             


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His 
    610                 615                 620                 


Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly 
625                 630                 635                 640 


Lys Gln Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln 
                645                 650                 655     


Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly 
            660                 665                 670         


Gly Gly Arg Pro Ala Leu Glu Ser Ile Val Ala Gln Leu Ser Arg Pro 
        675                 680                 685             


Asp Pro Ala Leu Ala Ala Leu Thr Asn Asp His Leu Val Ala Leu Ala 
    690                 695                 700                 


Cys Leu Gly Gly Arg Pro Ala Leu Asp Ala Val Lys Lys Gly Leu Gly 
705                 710                 715                 720 


Asp Pro Ile Ser Arg Ser Gln Leu Val Lys Ser Glu Leu Glu Glu Lys 
                725                 730                 735     


Lys Ser Glu Leu Arg His Lys Leu Lys Tyr Val Pro His Glu Tyr Ile 
            740                 745                 750         


Glu Leu Ile Glu Ile Ala Arg Asn Ser Thr Gln Asp Arg Ile Leu Glu 
        755                 760                 765             


Met Lys Val Met Glu Phe Phe Met Lys Val Tyr Gly Tyr Arg Gly Lys 
    770                 775                 780                 


His Leu Gly Gly Ser Arg Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly 
785                 790                 795                 800 


Ser Pro Ile Asp Tyr Gly Val Ile Val Asp Thr Lys Ala Tyr Ser Gly 
                805                 810                 815     


Gly Tyr Asn Leu Pro Ile Gly Gln Ala Asp Glu Met Gln Arg Tyr Val 
            820                 825                 830         


Glu Glu Asn Gln Thr Arg Asn Lys His Ile Asn Pro Asn Glu Trp Trp 
        835                 840                 845             


Lys Val Tyr Pro Ser Ser Val Thr Glu Phe Lys Phe Leu Phe Val Ser 
    850                 855                 860                 


Gly His Phe Lys Gly Asn Tyr Lys Ala Gln Leu Thr Arg Leu Asn His 
865                 870                 875                 880 


Ile Thr Asn Cys Asn Gly Ala Val Leu Ser Val Glu Glu Leu Leu Ile 
                885                 890                 895     


Gly Gly Glu Met Ile Lys Ala Gly Thr Leu Thr Leu Glu Glu Val Arg 
            900                 905                 910         


Arg Lys Phe Asn Asn Gly Glu Ile Asn Phe Ala Ala Asp 
        915                 920                 925 


<210>  25

<211>  925
<212>  PRT
<213>  artificial

<220>
<223>  TALEN i9 Left monomer

<400>  25
Met Gly Asp Pro Lys Lys Lys Arg Lys Val Ile Asp Ile Ala Asp Leu 
1               5                   10                  15      


Arg Thr Leu Gly Tyr Ser Gln Gln Gln Gln Glu Lys Ile Lys Pro Lys 
            20                  25                  30          


Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu Val Gly His Gly 
        35                  40                  45              


Phe Thr His Ala His Ile Val Ala Leu Ser Gln His Pro Ala Ala Leu 
    50                  55                  60                  


Gly Thr Val Ala Val Lys Tyr Gln Asp Met Ile Ala Ala Leu Pro Glu 
65                  70                  75                  80  


Ala Thr His Glu Ala Ile Val Gly Val Gly Lys Gln Trp Ser Gly Ala 
                85                  90                  95      


Arg Ala Leu Glu Ala Leu Leu Thr Val Ala Gly Glu Leu Arg Gly Pro 
            100                 105                 110         


Pro Leu Gln Leu Asp Thr Gly Gln Leu Leu Lys Ile Ala Lys Arg Gly 
        115                 120                 125             


Gly Val Thr Ala Val Glu Ala Val His Ala Trp Arg Asn Ala Leu Thr 
    130                 135                 140                 


Gly Ala Pro Leu Asn Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser 
145                 150                 155                 160 


Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
                165                 170                 175     


Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile 
            180                 185                 190         


Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Ala Leu 
        195                 200                 205             


Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val 
    210                 215                 220                 


Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
225                 230                 235                 240 


Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln 
                245                 250                 255     


Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr 
            260                 265                 270         


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro 
        275                 280                 285             


Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu 
    290                 295                 300                 


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu 
305                 310                 315                 320 


Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln 
                325                 330                 335     


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His 
            340                 345                 350         


Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly 
        355                 360                 365             


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
    370                 375                 380                 


Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn 
385                 390                 395                 400 


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu 
                405                 410                 415     


Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser 
            420                 425                 430         


Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
        435                 440                 445             


Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile 
    450                 455                 460                 


Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
465                 470                 475                 480 


Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val 
                485                 490                 495     


Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
            500                 505                 510         


Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln 
        515                 520                 525             


Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr 
    530                 535                 540                 


Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro 
545                 550                 555                 560 


Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu 
                565                 570                 575     


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu 
            580                 585                 590         


Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln 
        595                 600                 605             


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His 
    610                 615                 620                 


Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly 
625                 630                 635                 640 


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
                645                 650                 655     


Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly 
            660                 665                 670         


Gly Gly Arg Pro Ala Leu Glu Ser Ile Val Ala Gln Leu Ser Arg Pro 
        675                 680                 685             


Asp Pro Ala Leu Ala Ala Leu Thr Asn Asp His Leu Val Ala Leu Ala 
    690                 695                 700                 


Cys Leu Gly Gly Arg Pro Ala Leu Asp Ala Val His His Gly Leu Gly 
705                 710                 715                 720 


Asp Pro Ile Ser Arg Ser Gln Leu Val Lys Ser Glu Leu Glu Glu Lys 
                725                 730                 735     


Lys Ser Glu Leu Arg His Lys Leu Lys Tyr Val Pro His Glu Tyr Ile 
            740                 745                 750         


Glu Leu Ile Glu Ile Ala Arg Asn Ser Thr Gln Asp Arg Ile Leu Glu 
        755                 760                 765             


Met Lys Val Met Glu Phe Phe Met Lys Val Tyr Gly Tyr Arg Gly Lys 
    770                 775                 780                 


His Leu Gly Gly Ser Arg Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly 
785                 790                 795                 800 


Ser Pro Ile Asp Tyr Gly Val Ile Val Asp Thr Lys Ala Tyr Ser Gly 
                805                 810                 815     


Gly Tyr Asn Leu Pro Ile Gly Gln Ala Asp Glu Met Gln Arg Tyr Val 
            820                 825                 830         


Glu Glu Asn Gln Thr Arg Asn Lys His Ile Asn Pro Asn Glu Trp Trp 
        835                 840                 845             


Lys Val Tyr Pro Ser Ser Val Thr Glu Phe Lys Phe Leu Phe Val Ser 
    850                 855                 860                 


Gly His Phe Lys Gly Asn Tyr Lys Ala Gln Leu Thr Arg Leu Asn His 
865                 870                 875                 880 


Ile Thr Asn Cys Asn Gly Ala Val Leu Ser Val Glu Glu Leu Leu Ile 
                885                 890                 895     


Gly Gly Glu Met Ile Lys Ala Gly Thr Leu Thr Leu Glu Glu Val Arg 
            900                 905                 910         


Arg Lys Phe Asn Asn Gly Glu Ile Asn Phe Ala Ala Asp 
        915                 920                 925 


<210>  26

<211>  925
<212>  PRT
<213>  artificial

<220>
<223>  TALEN i9 right monomer

<400>  26
Met Gly Asp Pro Lys Lys Lys Arg Lys Val Ile Asp Ile Ala Asp Leu 
1               5                   10                  15      


Arg Thr Leu Gly Tyr Ser Gln Gln Gln Gln Glu Lys Ile Lys Pro Lys 
            20                  25                  30          


Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu Val Gly His Gly 
        35                  40                  45              


Phe Thr His Ala His Ile Val Ala Leu Ser Gln His Pro Ala Ala Leu 
    50                  55                  60                  


Gly Thr Val Ala Val Lys Tyr Gln Asp Met Ile Ala Ala Leu Pro Glu 
65                  70                  75                  80  


Ala Thr His Glu Ala Ile Val Gly Val Gly Lys Gln Trp Ser Gly Ala 
                85                  90                  95      


Arg Ala Leu Glu Ala Leu Leu Thr Val Ala Gly Glu Leu Arg Gly Pro 
            100                 105                 110         


Pro Leu Gln Leu Asp Thr Gly Gln Leu Leu Lys Ile Ala Lys Arg Gly 
        115                 120                 125             


Gly Val Thr Ala Val Glu Ala Val His Ala Trp Arg Asn Ala Leu Thr 
    130                 135                 140                 


Gly Ala Pro Leu Asn Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser 
145                 150                 155                 160 


Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
                165                 170                 175     


Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile 
            180                 185                 190         


Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Ala Leu 
        195                 200                 205             


Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val 
    210                 215                 220                 


Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
225                 230                 235                 240 


Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln 
                245                 250                 255     


Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr 
            260                 265                 270         


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro 
        275                 280                 285             


Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu 
    290                 295                 300                 


Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu 
305                 310                 315                 320 


Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln 
                325                 330                 335     


Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His 
            340                 345                 350         


Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly 
        355                 360                 365             


Lys Gln Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln 
    370                 375                 380                 


Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn 
385                 390                 395                 400 


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu 
                405                 410                 415     


Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser 
            420                 425                 430         


Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Ala Leu Leu Pro 
        435                 440                 445             


Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile 
    450                 455                 460                 


Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
465                 470                 475                 480 


Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val 
                485                 490                 495     


Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
            500                 505                 510         


Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln 
        515                 520                 525             


Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr 
    530                 535                 540                 


Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro 
545                 550                 555                 560 


Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu 
                565                 570                 575     


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu 
            580                 585                 590         


Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln 
        595                 600                 605             


Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His 
    610                 615                 620                 


Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly 
625                 630                 635                 640 


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
                645                 650                 655     


Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly 
            660                 665                 670         


Gly Gly Arg Pro Ala Leu Glu Ser Ile Val Ala Gln Leu Ser Arg Pro 
        675                 680                 685             


Asp Pro Ala Leu Ala Ala Leu Thr Asn Asp His Leu Val Ala Leu Ala 
    690                 695                 700                 


Cys Leu Gly Gly Arg Pro Ala Leu Asp Ala Val Lys Lys Gly Leu Gly 
705                 710                 715                 720 


Asp Pro Ile Ser Arg Ser Gln Leu Val Lys Ser Glu Leu Glu Glu Lys 
                725                 730                 735     


Lys Ser Glu Leu Arg His Lys Leu Lys Tyr Val Pro His Glu Tyr Ile 
            740                 745                 750         


Glu Leu Ile Glu Ile Ala Arg Asn Ser Thr Gln Asp Arg Ile Leu Glu 
        755                 760                 765             


Met Lys Val Met Glu Phe Phe Met Lys Val Tyr Gly Tyr Arg Gly Lys 
    770                 775                 780                 


His Leu Gly Gly Ser Arg Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly 
785                 790                 795                 800 


Ser Pro Ile Asp Tyr Gly Val Ile Val Asp Thr Lys Ala Tyr Ser Gly 
                805                 810                 815     


Gly Tyr Asn Leu Pro Ile Gly Gln Ala Asp Glu Met Gln Arg Tyr Val 
            820                 825                 830         


Glu Glu Asn Gln Thr Arg Asn Lys His Ile Asn Pro Asn Glu Trp Trp 
        835                 840                 845             


Lys Val Tyr Pro Ser Ser Val Thr Glu Phe Lys Phe Leu Phe Val Ser 
    850                 855                 860                 


Gly His Phe Lys Gly Asn Tyr Lys Ala Gln Leu Thr Arg Leu Asn His 
865                 870                 875                 880 


Ile Thr Asn Cys Asn Gly Ala Val Leu Ser Val Glu Glu Leu Leu Ile 
                885                 890                 895     


Gly Gly Glu Met Ile Lys Ala Gly Thr Leu Thr Leu Glu Glu Val Arg 
            900                 905                 910         


Arg Lys Phe Asn Asn Gly Glu Ile Asn Phe Ala Ala Asp 
        915                 920                 925 


<210>  27

<211>  280
<212>  DNA
<213>  homo sapiens

<220>
<223>  Intron 22 STAT3

<400>  27
gtaagtggct tcctttcccc gttttgcctt catttctaat atcctcagtt atccctggga     60
atgggacact gggtgagagt taatctgcca aaggttggaa gcccctgggc tatgtttagt    120
actcaaagtg accttgtgtg tttaaaaagc ttgagctttt atttttctgt tggagaccag    180
agtttgatgg cttgtgtgtg tgtgttttgt tctttttttt ttttccattg tgtcttgtca    240
accccccgtt tcccctcctg ctgcccccca tttcctacag                          280


<210>  28

<211>  54
<212>  DNA
<213>  artificial

<220>
<223>  Artificial splice site

<400>  28
acaagctagg cccttttgct aatcatgttc atactgtccc ttttttttcc acag           54


<210>  29

<211>  54
<212>  DNA
<213>  artificial

<220>
<223>  Artificial splice site

<400>  29
acaagctagg cccttttgct aatcatgttc atactgtccc ttttttttcc tcag           54


<210>  30

<211>  176
<212>  DNA
<213>  homo sapiens

<220>
<223>  Intron 7 STAT3

<400>  30
gtaagggcat aggtcggacc acttccccca tgtgtctcgc tcacttgcgg gatttcagcg     60
tcttgtggca gaacttgctt ggtttctaag aagttcctgc tctggagttg actaaagaat    120
gtggttagag acagtctgag gaaatgtttt ctgactttgt tttggtttcc aaccag        176


<210>  31

<211>  3385
<212>  DNA
<213>  homo sapiens

<220>
<223>  Intron 8 STAT3

<400>  31
gtaaaggatg aaagaagctt ttcctttctt tctcgaaagc tagattgaat tctgatctta     60
actgcaggcc cacagaattg gtactatatc tccaacgtgg ggacttttcc atattcaaat    120
ttagcccaag aattaaagtt tttactttat ttcggccagg cgctgtggct cacacctgta    180
atcccagcac tttgggagac caagatgggc ggatcacttg aggtcaggag tttgagacca    240
gcctggccaa catggtgaaa acacatctct actaaaaaca taaaaaaatt agccgggcgt    300
ggtggtgcgc acctgtagtc ccagctactc tgggcggctg aggcaggaga atcacttgaa    360
cctgggatat ggaagttgca gtgagcggag atcttactac cgcacaccaa ccagcctggg    420
agacagagtg agactccatc tcaaaaaaat aaaaataaaa taaagttttt actttatttg    480
gagaaacttt gttttaaaaa atgtatttat attattatat tttaagtata ttttacttaa    540
taattcaatt aaggcttttg gtttaactgt atttaacaga tagacaaacc ttttaatttt    600
agttatttta gtaatctaaa atgacacatg ccctttttaa gggaaaaaat tcaaatacag    660
aaaattaatc aagagaagaa aaaattttta aatgaaatca tcagcagtac tagtagttaa    720
aatttagttg atgctcaatc tagacatctg tcattatgta tatacacatt atgtatatac    780
acataaagat agaaatttat acagtttata ttaggatcat ttttttttct ttttttggag    840
tcagggtctc actgtgttac ccagtctaga gtacagttat gcagtcatgg ctcactggag    900
ccttgacctc ctgggctcag gcagtcttcc caccttagcc ttctcagtag ctgggactac    960
aggcatgcac caccacacct ggctaatttt taaatttttt atagagacag ggtcttactt   1020
tgttgcctgg gctggtctca aattcctggg ctcaagggat catcccactt cggcctctca   1080
aaagctctgg aattatagat gtgagctgcc gtgcccagcc caggatcttc ctttatatgc   1140
ttttctgtaa tttgcacttt taccttcatc cagcatatct tactgcaacc cttcctgtgc   1200
aaggccctat agtgagcatg ttgcaccagc ttgccttagg agaaacttga gatacagagc   1260
ctgcactgga aatttagcgc aactctacat gagaatgcct gtctattcat atcctcacta   1320
accctgagtg ttgttaattt actgaaagca gttttaaatg cttcctgacc agggaacgaa   1380
gaagcttaag ttctgggaat gggaggatag aagtgccaga aaagagctca ggagttcaga   1440
aatccctgca gcggtccccc tccctctcct ttcactttct gtctttctgg tcttttggtc   1500
tttgttacac tagtgataaa ccatcaaaga atgatggaat gatgctaact tctctctttt   1560
tttaattttt ttgagacaga gtctcactct gtcacccagg ttagagtgca gtggcatgat   1620
cttggcttac tgcaacctcc tcctcccagg ttcaagcgat tcttagtcac aaccttccaa   1680
gtagctggga ttacaggccc atgccaccat gcctggctat ttttttgtat tttagtagat   1740
cgacctgcct cggcctctca aatttttggg attacaggtg tcagccactg cacctggcct   1800
aatatctcta ttcttggaga tagatttaat gagctttttc tccctctcta ttcacttatt   1860
ccttgtgcat gttatcaata ttttgaaaca taatgtcatg tcctttgatc agttgaaggc   1920
tgacattgaa aaggcttatg gggattgggt gttgtggctc acgcctgtaa atcccaatgc   1980
tttgggaggc agagtcggga ggatcacttg aacccaggag tttgagacca gcctgggcaa   2040
caaagtgaga tcccatccct acaaaaattt aaaaaactag acatgtgcca ttacacttca   2100
gcctgggtga cagagtgaga ctccatctca aaaaactaaa ctaaactaaa caggcatggt   2160
ggcacacacc tatagttcta gctactcagg aagctgaggt aggaggatca ctcatgtcca   2220
ggagttggag gaggcagtga gctatgatca tgccattgca ctgcactagg ccacagagtg   2280
ggaccctgtc tcaaaaaaaa aaaaagaaag aaagaaaaga aagggctcat gtagttcaag   2340
cccttctctt catgcaaggg gatgctaagg cccatgatgg tgaagggcct ggcaaagctt   2400
gcacagatag tgtgtgacag agctggctca aacccatctt tgggagctgt ctaatctctt   2460
tttctgagtc tttatgttca tagacaagtt aggatgagta aagtaagtgc taaattccat   2520
atttcgtgtt ctgcatatct gggctcagat gcttgtcatt ttccagtgat aactccatca   2580
atgcctccta gtggtataaa ttttaatact tcttgtgtgc ccagccccct cttagaaatt   2640
tgagatttta ggaagggact agtaataaaa ggtaaaataa attattttct ggccaggcat   2700
ggtggctcac acctgtaatg ccagtacttc gggaggtcga ggcagatgga tcacctgagg   2760
tcaggagttc aagaccagcc tggccaacaa ggcaaaatcc catctctact aaaaatgcaa   2820
aaattatccg ggagtggtgg tgggtgcctg taatcccagc tacttgggag gctgaggcag   2880
gagaatcact tgaacttggg aggcggaggt tgcagtgagc tgagactgtg ccactgcact   2940
ccagcctggg caacagagta agactctatc tcaaaaaaaa aaaaaaaaaa aaaaaggcca   3000
ggcgcagtgg cttacacctg taatctctca ggaggctcag gcaggagaat cacttgaacc   3060
cgggaaatgg aggttgcagt gagccgagat tgcaccactg cactccagct caaaaaataa   3120
ataaataaat aaattatttt ctttttttat ttattttttc agcatccacc caacatggtg   3180
aaaaattcct cttttcttaa tgtcactgaa ctgtaaactt aagatgaaaa attgtaaatt   3240
tcatgctata tatatttcac cacaataaaa aaattccttg ttcttattgt agtggtctcc   3300
atgtcttcag tatttccttc cccttctcca tctcacctgt atacattcac tttggtaatt   3360
agcatctttc ttaatttatt ggcag                                         3385


<210>  32

<211>  125
<212>  DNA
<213>  homo sapiens

<220>
<223>  Intron 9 STAT3

<400>  32
gtaatttagc atccttgtcc ctttccctca tctaaaaaat acctaaagac tcacgtggta     60
gagtgagagg cgggctgact tctggtcatg gccgtggcgc gtgagcccat cttctctttc    120
ctcag                                                                125


<210>  33

<211>  2253
<212>  DNA
<213>  artificial

<220>
<223>  STAT3 inserted template sequence 1

<400>  33
tgatacaagc taggcccttt tgctaatcat gttcatactg tccctttttt ttccacagag     60
catcgtgagt gagctggctg ggttgctttc agctatggaa tatgtgcaaa agacgttgac    120
agacgaggaa ctggccgact ggaagcggag gcaacaaatt gcttgcattg gaggaccacc    180
caatatatgc ctggatagat tggagaactg gataacgtca ttagcagaaa gccaactgca    240
aactagacag caaataaaga agctggaaga actccagcaa aaagtttcct ataagggtga    300
ccctatagtg cagcacaggc ccatgttgga ggaacgcatt gtggagttgt ttagaaatct    360
gatgaaaagt gcctttgtgg tggagcgaca accgtgcatg cctatgcacc ctgaccggcc    420
cttggtgata aagaccggag tacaattcac tactaaagtg aggctgctcg taaagttccc    480
tgaactcaat taccagttga agataaaagt gtgcatcgat aaggactccg gcgatgttgc    540
cgcgctccgg ggaagtcgaa agttcaacat cttgggcacc aatacaaagg tgatgaacat    600
ggaggaatca aacaacgggt ccctttccgc ggagttcaaa catttgacat tgcgcgagca    660
gagatgtggg aacgggggaa gagcaaattg tgacgcttct ctgatcgtaa ctgaggagct    720
gcatctcata acattcgaga ctgaggtcta ccatcaggga ttgaagatcg acctcgaaac    780
tcattcactg cctgtagttg ttattagtaa tatttgccag atgccgaatg cgtgggctag    840
catactttgg tataacatgc ttacgaataa tccaaagaac gttaattttt tcactaaacc    900
tccaatcgga acttgggacc aggtcgcaga agtgctgagc tggcaatttt cctccaccac    960
caaacgcggt cttagcatcg aacaattgac gaccctcgca gaaaagcttt tgggtcctgg   1020
cgttaattac tcagggtgtc agataacttg ggcaaagttc tgcaaagaaa acatggcagg   1080
taagggcttt tcattttggg tctggctgga taacattata gatttggtga aaaagtacat   1140
tcttgccctg tggaacgaag gctacatcat gggtttcatt agcaaggagc gcgagagagc   1200
gatcctgtca actaaacccc ctggaacgtt tctccttaga ttttccgaaa gcagcaagga   1260
aggtggcgtg actttcacgt gggttgaaaa ggacatcagc ggaaagacgc aaattcagag   1320
cgttgaacct tacaccaagc agcaacttaa caacatgagc ttcgccgaga taataatggg   1380
ttacaaaata atggacgcta ctaatatcct cgtctcaccc ctcgtgtact tgtatccaga   1440
cattcccaaa gaggaggcgt tcgggaagta ctgtcgcccg gagtcacaag aacatcctga   1500
agctgaccca ggaagtgcag ctccgtacct taagaccaag tttatctgtg tgacaccgta   1560
agtggcttcc tttccccgtt ttgccttcat ttctaatatc ctcagttatc cctgggaatg   1620
ggacactggg tgagagttaa tctgccaaag gttggaagcc cctgggctat gtttagtact   1680
caaagtgacc ttgtgtgttt aaaaagcttg agcttttatt tttctgttgg aagaccagag   1740
tttgatggct tgtgtgtgtg tgttttgttc tttttttttt ttccattgtg tcttgtcaac   1800
cccccgtttc ccctcctgct gccccccatt tcctacagaa cgacctgcag caataccatt   1860
gacctgccga tgtccccccg cactttagat tcattgatgc agtttggaaa taatggtgaa   1920
ggtgctgaac catccgctgg tggacagttt gagagcctta cgtttgatat ggagttgaca   1980
agcgagtgtg ctacatcacc tatgtgagca gatccagaca tgataagata cattgatgag   2040
tttggacaaa ccacaactag aatgcagtga aaaaaatgct ttatttgtga aatttgtgat   2100
gctattgctt tatttgtaac cattataagc tgcaataaac aagttaacaa caacaattgc   2160
attcatttta tgtttcaggt tcagggggag gtgtgggagg ttttttaaag caagtaaaac   2220
ctctacaaat gtggtacggc ttgattatga tca                                2253


<210>  34

<211>  2252
<212>  DNA
<213>  artificial

<220>
<223>  STAT3 inserted template sequence 2

<400>  34
tgatacaagc taggcccttt tgctaatcat gttcatactg tccctttttt ttcctcagag     60
catcgtgagt gagctggctg ggttgctttc agctatggaa tatgtgcaaa agacgttgac    120
agacgaggaa ctggccgact ggaagcggag gcaacaaatt gcttgcattg gaggaccacc    180
caatatatgc ctggatagat tggagaactg gataacgtca ttagcagaaa gccaactgca    240
aactagacag caaataaaga agctggaaga actccagcaa aaagtttcct ataagggtga    300
ccctatagtg cagcacaggc ccatgttgga ggaacgcatt gtggagttgt ttagaaatct    360
gatgaaaagt gcctttgtgg tggagcgaca accgtgcatg cctatgcacc ctgaccggcc    420
cttggtgata aagaccggag tacaattcac tactaaagtg aggctgctcg taaagttccc    480
tgaactcaat taccagttga agataaaagt gtgcatcgat aaggactccg gcgatgttgc    540
cgcgctccgg ggaagtcgaa agttcaacat cttgggcacc aatacaaagg tgatgaacat    600
ggaggaatca aacaacgggt ccctttccgc ggagttcaaa catttgacat tgcgcgagca    660
gagatgtggg aacgggggaa gagcaaattg tgacgcttct ctgatcgtaa ctgaggagct    720
gcatctcata acattcgaga ctgaggtcta ccatcaggga ttgaagatcg acctcgaaac    780
tcattcactg cctgtagttg ttattagtaa tatttgccag atgccgaatg cgtgggctag    840
catactttgg tataacatgc ttacgaataa tccaaagaac gttaattttt tcactaaacc    900
tccaatcgga acttgggacc aggtcgcaga agtgctgagc tggcaatttt cctccaccac    960
caaacgcggt cttagcatcg aacaattgac gaccctcgca gaaaagcttt tgggtcctgg   1020
cgttaattac tcagggtgtc agataacttg ggcaaagttc tgcaaagaaa acatggcagg   1080
caagggcttt tcattttggg tctggctgga taacattata gatttggtga aaaagtacat   1140
tcttgccctg tggaacgaag gctacatcat gggtttcatt agcaaggagc gcgagagagc   1200
gatcctgtca actaaacccc ctggaacgtt tctccttcgc ttttccgaaa gcagcaagga   1260
aggtggcgtg actttcacgt gggttgaaaa ggacatcagc ggaaagacgc aaattcagag   1320
cgttgaacct tacaccaagc agcaacttaa caacatgagc ttcgccgaga taataatggg   1380
ttacaaaata atggacgcta ctaatatcct cgtctcaccc ctcgtgtact tgtatccgga   1440
cattcccaaa gaggaggcgt tcgggaagta ctgtcgcccg gagtcacaag aacatcctga   1500
agctgaccca ggaagtgcag ctccgtacct taagaccaag tttatctgcg tgacaccgta   1560
agtggcttcc tttccccgtt ttgccttcat ttctaatatc ctcagttatc cctgggaatg   1620
ggacactggg tgagagttaa tctgccaaag gttggaagcc cctgggctat gtttagtact   1680
caaagtgacc ttgtgtgttt aaaaagcttg agcttttatt tttctgttgg agaccagagt   1740
ttgatggctt gtgtgtgtgt gttttgttct tttttttttt tccattgtgt cttgtcaacc   1800
ccccgtttcc cctcctgctg ccccccattt cctacagaac gacctgcagc aataccattg   1860
acctgccgat gtccccccgc actttagatt cattgatgca gtttggaaat aatggtgaag   1920
gtgctgaacc atccgctggt ggacagtttg agagccttac gtttgatatg gagttgacaa   1980
gcgagtgtgc tacatcacct atgtgagcag atccagacat gataagatac attgatgagt   2040
ttggacaaac cacaactaga atgcagtgaa aaaaatgctt tatttgtgaa atttgtgatg   2100
ctattgcttt atttgtaacc attataagct gcaataaaca agttaacaac aacaattgca   2160
ttcattttat gtttcaggtt cagggggagg tgtgggaggt tttttaaagc aagtaaaacc   2220
tctacaaatg tggtacggct tgattatgat ca                                 2252


<210>  35

<211>  2252
<212>  DNA
<213>  artificial

<220>
<223>  STAT3 inserted template sequence 3

<400>  35
tgatacaagc taggcccttt tgctaatcat gttcatactg tccctttttt ttcctcagag     60
catcgtgagt gagctggctg ggttgctttc agctatggaa tatgtgcaaa agacgttgac    120
agacgaggaa ctggccgact ggaagcggag gcaacaaatt gcttgcattg gaggaccacc    180
caatatatgc ctggatagat tggagaactg gataacgtca ttagcagaaa gccaactgca    240
aactagacag caaataaaga agctggaaga actccagcaa aaagtttcct ataagggtga    300
ccctatagtg cagcacaggc ccatgttgga ggaacgcatt gtggagttgt ttagaaatct    360
gatgaaaagt gcctttgtgg tggagcgaca accgtgcatg cctatgcacc ctgaccggcc    420
cttggtgata aagaccggag tacaattcac tactaaagtg aggctgctcg taaagttccc    480
tgaactcaat taccagttga agataaaagt gtgcatcgat aaggactccg gcgatgttgc    540
cgcgctccgg ggaagtcgaa agttcaacat cttgggcacc aatacaaagg tgatgaacat    600
ggaggaatca aacaacgggt ccctttccgc ggagttcaaa catttgacat tgcgcgagca    660
gagatgtggg aacgggggaa gagcaaattg tgacgcttct ctgatcgtaa ctgaggagct    720
gcatctcata acattcgaga ctgaggtcta ccatcaggga ttgaagatcg acctcgaaac    780
tcattcactg cctgtagttg ttattagtaa tatttgccag atgccgaatg cgtgggctag    840
catactttgg tataacatgc ttacgaataa tccaaagaac gttaattttt tcactaaacc    900
tccaatcgga acttgggacc aggtcgcaga agtgctgagc tggcaatttt cctccaccac    960
caaacgcggt cttagcatcg aacaattgac gaccctcgca gaaaagcttt tgggtcctgg   1020
cgttaattac tcagggtgtc agataacttg ggcaaagttc tgcaaagaaa acatggcagg   1080
caagggcttt tcattttggg tctggctgga taacattata gatttggtga aaaagtacat   1140
tcttgccctg tggaacgaag gctacatcat gggtttcatt agcaaggagc gcgagagagc   1200
gatcctgtca actaaacccc ctggaacgtt tctccttcgc ttttccgaaa gcagcaagga   1260
aggtggcgtg actttcacgt gggttgaaaa ggacatcagc ggaaagacgc aaattcagag   1320
cgttgaacct tacaccaagc agcaacttaa caacatgagc ttcgccgaga taataatggg   1380
ttacaaaata atggacgcta ctaatatcct cgtctcaccc ctcgtgtact tgtatccgga   1440
cattcccaaa gaggaggcgt tcgggaagta ctgtcgcccg gagtcacaag aacatcctga   1500
agctgaccca ggaagtgcag ctccgtacct taagaccaag tttatctgtg tgacaccgta   1560
agtggcttcc tttccccgtt ttgccttcat ttctaatatc ctcagttatc cctgggaatg   1620
ggacactggg tgagagttaa tctgccaaag gttggaagcc cctgggctat gtttagtact   1680
caaagtgacc ttgtgtgttt aaaaagcttg agcttttatt tttctgttgg agaccagagt   1740
ttgatggctt gtgtgtgtgt gttttgttct tttttttttt tccattgtgt cttgtcaacc   1800
ccccgtttcc cctcctgctg ccccccattt cctacagaac gacctgcagc aataccattg   1860
acctgccgat gtccccccgc actttagatt cattgatgca gtttggaaat aatggtgaag   1920
gtgctgaacc atccgctggt ggacagtttg agagccttac gtttgatatg gagttgacaa   1980
gcgagtgtgc tacatcacct atgtgagcag atccagacat gataagatac attgatgagt   2040
ttggacaaac cacaactaga atgcagtgaa aaaaatgctt tatttgtgaa atttgtgatg   2100
ctattgcttt atttgtaacc attataagct gcaataaaca agttaacaac aacaattgca   2160
ttcattttat gtttcaggtt cagggggagg tgtgggaggt tttttaaagc aagtaaaacc   2220
tctacaaatg tggtacggct tgattatgat ca                                 2252


<210>  36

<211>  2252
<212>  DNA
<213>  artificial

<220>
<223>  STAT3 inserted template sequence 4

<400>  36
tgatacaagc taggcccttt tgctaatcat gttcatactg tccctttttt ttcctcagag     60
catcgtgagt gagctggcgg ggcttttgtc agcgatggag tacgtgcaga aaactctcac    120
ggacgaggag ctggctgact ggaagaggcg gcaacagatt gcctgcattg gaggcccgcc    180
caacatctgc ctagatcggc tagaaaactg gataacgtca ttagcagaat ctcaacttca    240
gacccgtcaa caaattaaga aactggagga gttgcagcaa aaagtttcct acaaagggga    300
ccccattgta cagcaccggc cgatgctgga ggagagaatc gtggagctgt ttagaaactt    360
aatgaaaagc gcctttgtgg tggagcggca gccctgcatg cccatgcatc ctgaccggcc    420
cctcgtcatc aagaccggcg tccagttcac tactaaagtc agattgctgg tcaaattccc    480
tgagttgaat tatcagctta aaattaaagt gtgcattgac aaagactctg gggacgttgc    540
agctctcaga ggatcccgga agttcaacat cttgggcacc aacacaaaag tgatgaacat    600
ggaagaatcc aacaacggca gcctctctgc cgaattcaaa cacttgaccc tgagggagca    660
gagatgtggg aatgggggcc gagccaattg tgatgcttcc ctgattgtga ctgaggagct    720
gcacctgatc acctttgaga ccgaggtgta tcaccaaggc ctcaagattg acctagagac    780
ccactccttg ccagttgtgg tgatctccaa catctgtcag atgccaaatg cctgggcgtc    840
catcctgtgg tacaacatgc tgaccaacaa tcccaagaat gtaaactttt ttaccaagcc    900
cccaattgga acctgggatc aagtggccga ggtcctgagc tggcagttct cctccaccac    960
caagcgagga ctgagcatcg aacaattgac gaccctggca gagaaactct tgggacctgg   1020
tgtgaattat tcagggtgtc agatcacatg ggctaaattt tgcaaagaaa acatggctgg   1080
caagggcttc tccttctggg tctggctgga caatatcatt gaccttgtga aaaagtacat   1140
cctggccctt tggaacgaag gatacatcat gggctttatc agtaaggagc gggagagagc   1200
gatcctgtca actaaacctc caggcacctt cctgctaaga ttcagtgaaa gcagcaaaga   1260
aggaggcgtc actttcactt gggtggagaa ggacatcagc ggaaagacgc aaattcagag   1320
cgtggaacca tacacaaagc agcagctgaa caacatgtca tttgctgaaa tcatcatggg   1380
ctataagatc atggatgcta ccaatatcct ggtgtctcca ctggtctatc tctatccgga   1440
cattcccaaa gaggaggcgt tcggaaagta ctgtcgcccg gagtcacagg agcatcctga   1500
agctgaccca ggcagcgctg ccccatacct gaagaccaag tttatctgtg tgacaccgta   1560
agtggcttcc tttccccgtt ttgccttcat ttctaatatc ctcagttatc cctgggaatg   1620
ggacactggg tgagagttaa tctgccaaag gttggaagcc cctgggctat gtttagtact   1680
caaagtgacc ttgtgtgttt aaaaagcttg agcttttatt tttctgttgg agaccagagt   1740
ttgatggctt gtgtgtgtgt gttttgttct tttttttttt tccattgtgt cttgtcaacc   1800
ccccgtttcc cctcctgctg ccccccattt cctacagaac gacctgcagc aataccattg   1860
acctgccgat gtccccccgc actttagatt cattgatgca gtttggaaat aatggtgaag   1920
gtgctgaacc ctcagcagga ggacagtttg agagccttac gtttgatatg gagttgacct   1980
cggagtgcgc tacctccccc atgtgagcag atccagacat gataagatac attgatgagt   2040
ttggacaaac cacaactaga atgcagtgaa aaaaatgctt tatttgtgaa atttgtgatg   2100
ctattgcttt atttgtaacc attataagct gcaataaaca agttaacaac aacaattgca   2160
ttcattttat gtttcaggtt cagggggagg tgtgggaggt tttttaaagc aagtaaaacc   2220
tctacaaatg tggtacggct tgattatgat ca                                 2252


<210>  37

<211>  2252
<212>  DNA
<213>  artificial

<220>
<223>  STAT3 inserted template sequence 5

<400>  37
tgatacaagc taggcccttt tgctaatcat gttcatactg tccctttttt ttcctcagag     60
catcgtgagt gagctggctg ggttgctttc agctatggaa tatgtgcaaa agacgttgac    120
agacgaggaa ctggccgact ggaagcggag gcaacaaatt gcttgcattg gaggaccacc    180
caatatatgc ctggatagat tggagaactg gataacgtca ttagcagaaa gccaactgca    240
aactagacag caaataaaga agctggaaga actccagcaa aaagtttcct ataagggtga    300
ccctatagtg cagcacaggc ccatgttgga ggaacgcatt gtggagttgt ttagaaatct    360
gatgaaaagt gcctttgtgg tggagcgaca accgtgcatg cctatgcacc ctgaccggcc    420
cttggtgata aagaccggag tacaattcac tactaaagtg aggctgctcg taaagttccc    480
tgaactcaat taccagttga agataaaagt gtgcatcgat aaagactctg gggacgttgc    540
agctctcaga ggatcccgga agttcaacat cttgggcacc aacacaaaag tgatgaacat    600
ggaagaatcc aacaacggca gcctctctgc cgaattcaaa cacttgaccc tgagggagca    660
gagatgtggg aatgggggcc gagccaattg tgatgcttcc ctgattgtga ctgaggagct    720
gcacctgatc acctttgaga ccgaggtgta tcaccaaggc ctcaagattg acctagagac    780
ccactccttg ccagttgtgg tgatctccaa catctgtcag atgccaaatg cctgggcgtc    840
catcctgtgg tacaacatgc tgaccaacaa tcccaagaat gtaaactttt ttaccaagcc    900
cccaattgga acctgggatc aagtggccga ggtcctgagc tggcagttct cctccaccac    960
caagcgagga ctgagcatcg aacaattgac gaccctggca gagaaactct tgggacctgg   1020
tgtgaattat tcagggtgtc agatcacatg ggctaaattt tgcaaagaaa acatggctgg   1080
caagggcttc tccttctggg tctggctgga caatatcatt gaccttgtga aaaagtacat   1140
cctggccctt tggaacgaag gatacatcat gggctttatc agtaaggagc gggagagagc   1200
gatcctgtca actaaacctc caggcacctt cctgctaaga ttcagtgaaa gcagcaaaga   1260
aggaggcgtc actttcactt gggtggagaa ggacatcagc ggaaagacgc aaattcagag   1320
cgtggaacca tacacaaagc agcagctgaa caacatgtca tttgctgaaa tcatcatggg   1380
ctataagatc atggatgcta ccaatatcct ggtgtctcca ctggtctatc tctatccgga   1440
cattcccaaa gaggaggcgt tcggaaagta ctgtcgcccg gagtcacagg agcatcctga   1500
agctgaccca ggcagcgctg ccccatacct gaagaccaag tttatctgtg tgacaccgta   1560
agtggcttcc tttccccgtt ttgccttcat ttctaatatc ctcagttatc cctgggaatg   1620
ggacactggg tgagagttaa tctgccaaag gttggaagcc cctgggctat gtttagtact   1680
caaagtgacc ttgtgtgttt aaaaagcttg agcttttatt tttctgttgg agaccagagt   1740
ttgatggctt gtgtgtgtgt gttttgttct tttttttttt tccattgtgt cttgtcaacc   1800
ccccgtttcc cctcctgctg ccccccattt cctacagaac gacctgcagc aataccattg   1860
acctgccgat gtccccccgc actttagatt cattgatgca gtttggaaat aatggtgaag   1920
gtgctgaacc ctcagcagga ggacagtttg agagccttac gtttgatatg gagttgacct   1980
cggagtgcgc tacctccccc atgtgagcag atccagacat gataagatac attgatgagt   2040
ttggacaaac cacaactaga atgcagtgaa aaaaatgctt tatttgtgaa atttgtgatg   2100
ctattgcttt atttgtaacc attataagct gcaataaaca agttaacaac aacaattgca   2160
ttcattttat gtttcaggtt cagggggagg tgtgggaggt tttttaaagc aagtaaaacc   2220
tctacaaatg tggtacggct tgattatgat ca                                 2252


<210>  38

<211>  49
<212>  DNA
<213>  homo sapiens

<220>
<223>  target sequence TALEN i7

<400>  38
tctaagaagt tcctgctctg gagttgacta aagaatgtgg ttagagaca                 49


<210>  39

<211>  49
<212>  DNA
<213>  homo sapiens

<220>
<223>  target sequence TALEN i8b

<400>  39
tagaaatttg agattttagg aagggactag taataaaagg taaaataaa                 49


<210>  40

<211>  49
<212>  DNA
<213>  homo sapiens

<220>
<223>  target sequence TALEN i9

<400>  40
tgacttctgg tcatggccgt ggcgcgtgag cccatcttct ctttcctca                 49


<210>  41

<211>  2922
<212>  DNA
<213>  artificial

<220>
<223>  STAT3  DNA repair template intron 7 sequence 1

<400>  41
gtcaaggagt attccctcag gtcaaggagt tttttcttcc ttcgcagaca tgcaagatct     60
gaatggaaac aaccagtcag tgaccaggca gaagatgcag cagctggaac agatgctcac    120
tgcgctggac cagatgcgga gagtaagggc ataggtcgga ccacttcccc catgtgtctc    180
gctcacttgc gggatttcag cgtcttgtgg cagaacttgc ttggtttcta agaagttcct    240
gctctggagt tgatacaagc taggcccttt tgctaatcat gttcatactg tccctttttt    300
ttccacagag catcgtgagt gagctggctg ggttgctttc agctatggaa tatgtgcaaa    360
agacgttgac agacgaggaa ctggccgact ggaagcggag gcaacaaatt gcttgcattg    420
gaggaccacc caatatatgc ctggatagat tggagaactg gataacgtca ttagcagaaa    480
gccaactgca aactagacag caaataaaga agctggaaga actccagcaa aaagtttcct    540
ataagggtga ccctatagtg cagcacaggc ccatgttgga ggaacgcatt gtggagttgt    600
ttagaaatct gatgaaaagt gcctttgtgg tggagcgaca accgtgcatg cctatgcacc    660
ctgaccggcc cttggtgata aagaccggag tacaattcac tactaaagtg aggctgctcg    720
taaagttccc tgaactcaat taccagttga agataaaagt gtgcatcgat aaggactccg    780
gcgatgttgc cgcgctccgg ggaagtcgaa agttcaacat cttgggcacc aatacaaagg    840
tgatgaacat ggaggaatca aacaacgggt ccctttccgc ggagttcaaa catttgacat    900
tgcgcgagca gagatgtggg aacgggggaa gagcaaattg tgacgcttct ctgatcgtaa    960
ctgaggagct gcatctcata acattcgaga ctgaggtcta ccatcaggga ttgaagatcg   1020
acctcgaaac tcattcactg cctgtagttg ttattagtaa tatttgccag atgccgaatg   1080
cgtgggctag catactttgg tataacatgc ttacgaataa tccaaagaac gttaattttt   1140
tcactaaacc tccaatcgga acttgggacc aggtcgcaga agtgctgagc tggcaatttt   1200
cctccaccac caaacgcggt cttagcatcg aacaattgac gaccctcgca gaaaagcttt   1260
tgggtcctgg cgttaattac tcagggtgtc agataacttg ggcaaagttc tgcaaagaaa   1320
acatggcagg taagggcttt tcattttggg tctggctgga taacattata gatttggtga   1380
aaaagtacat tcttgccctg tggaacgaag gctacatcat gggtttcatt agcaaggagc   1440
gcgagagagc gatcctgtca actaaacccc ctggaacgtt tctccttaga ttttccgaaa   1500
gcagcaagga aggtggcgtg actttcacgt gggttgaaaa ggacatcagc ggaaagacgc   1560
aaattcagag cgttgaacct tacaccaagc agcaacttaa caacatgagc ttcgccgaga   1620
taataatggg ttacaaaata atggacgcta ctaatatcct cgtctcaccc ctcgtgtact   1680
tgtatccaga cattcccaaa gaggaggcgt tcgggaagta ctgtcgcccg gagtcacaag   1740
aacatcctga agctgaccca ggaagtgcag ctccgtacct taagaccaag tttatctgtg   1800
tgacaccgta agtggcttcc tttccccgtt ttgccttcat ttctaatatc ctcagttatc   1860
cctgggaatg ggacactggg tgagagttaa tctgccaaag gttggaagcc cctgggctat   1920
gtttagtact caaagtgacc ttgtgtgttt aaaaagcttg agcttttatt tttctgttgg   1980
aagaccagag tttgatggct tgtgtgtgtg tgttttgttc tttttttttt ttccattgtg   2040
tcttgtcaac cccccgtttc ccctcctgct gccccccatt tcctacagaa cgacctgcag   2100
caataccatt gacctgccga tgtccccccg cactttagat tcattgatgc agtttggaaa   2160
taatggtgaa ggtgctgaac catccgctgg tggacagttt gagagcctta cgtttgatat   2220
ggagttgaca agcgagtgtg ctacatcacc tatgtgagca gatccagaca tgataagata   2280
cattgatgag tttggacaaa ccacaactag aatgcagtga aaaaaatgct ttatttgtga   2340
aatttgtgat gctattgctt tatttgtaac cattataagc tgcaataaac aagttaacaa   2400
caacaattgc attcatttta tgtttcaggt tcagggggag gtgtgggagg ttttttaaag   2460
caagtaaaac ctctacaaat gtggtacggc ttgattatga tcatgactaa agaatgtggt   2520
tagagacagt ctgaggaaat gttttctgac tttgttttgg tttccaacca gagcatcgtg   2580
agtgagctgg cggggctttt gtcagcgatg gagtacgtgc agaaaactct cacggacgag   2640
gagctggctg actggaagag gcggcaacag attgcctgca ttggaggccc gcccaacatc   2700
tgcctagatc ggctagaaaa ctggtaaagg atgaaagaag cttttccttt ctttctcgaa   2760
agctagattg aattctgatc ttaactgcag gcccacagaa ttggtactat atctccaacg   2820
tggggacttt tccatattca aatttagccc aagaattaaa gtttttactt tatttcggcc   2880
aggcgctgtg gctcacacct gtaatcccag cactttggga ga                      2922


<210>  42

<211>  2921
<212>  DNA
<213>  artificial

<220>
<223>  STAT3  DNA repair template intron 7 sequence 2

<400>  42
gtcaaggagt attccctcag gtcaaggagt tttttcttcc ttcgcagaca tgcaagatct     60
gaatggaaac aaccagtcag tgaccaggca gaagatgcag cagctggaac agatgctcac    120
tgcgctggac cagatgcgga gagtaagggc ataggtcgga ccacttcccc catgtgtctc    180
gctcacttgc gggatttcag cgtcttgtgg cagaacttgc ttggtttcta agaagttcct    240
gctctggagt tgatacaagc taggcccttt tgctaatcat gttcatactg tccctttttt    300
ttcctcagag catcgtgagt gagctggctg ggttgctttc agctatggaa tatgtgcaaa    360
agacgttgac agacgaggaa ctggccgact ggaagcggag gcaacaaatt gcttgcattg    420
gaggaccacc caatatatgc ctggatagat tggagaactg gataacgtca ttagcagaaa    480
gccaactgca aactagacag caaataaaga agctggaaga actccagcaa aaagtttcct    540
ataagggtga ccctatagtg cagcacaggc ccatgttgga ggaacgcatt gtggagttgt    600
ttagaaatct gatgaaaagt gcctttgtgg tggagcgaca accgtgcatg cctatgcacc    660
ctgaccggcc cttggtgata aagaccggag tacaattcac tactaaagtg aggctgctcg    720
taaagttccc tgaactcaat taccagttga agataaaagt gtgcatcgat aaggactccg    780
gcgatgttgc cgcgctccgg ggaagtcgaa agttcaacat cttgggcacc aatacaaagg    840
tgatgaacat ggaggaatca aacaacgggt ccctttccgc ggagttcaaa catttgacat    900
tgcgcgagca gagatgtggg aacgggggaa gagcaaattg tgacgcttct ctgatcgtaa    960
ctgaggagct gcatctcata acattcgaga ctgaggtcta ccatcaggga ttgaagatcg   1020
acctcgaaac tcattcactg cctgtagttg ttattagtaa tatttgccag atgccgaatg   1080
cgtgggctag catactttgg tataacatgc ttacgaataa tccaaagaac gttaattttt   1140
tcactaaacc tccaatcgga acttgggacc aggtcgcaga agtgctgagc tggcaatttt   1200
cctccaccac caaacgcggt cttagcatcg aacaattgac gaccctcgca gaaaagcttt   1260
tgggtcctgg cgttaattac tcagggtgtc agataacttg ggcaaagttc tgcaaagaaa   1320
acatggcagg caagggcttt tcattttggg tctggctgga taacattata gatttggtga   1380
aaaagtacat tcttgccctg tggaacgaag gctacatcat gggtttcatt agcaaggagc   1440
gcgagagagc gatcctgtca actaaacccc ctggaacgtt tctccttcgc ttttccgaaa   1500
gcagcaagga aggtggcgtg actttcacgt gggttgaaaa ggacatcagc ggaaagacgc   1560
aaattcagag cgttgaacct tacaccaagc agcaacttaa caacatgagc ttcgccgaga   1620
taataatggg ttacaaaata atggacgcta ctaatatcct cgtctcaccc ctcgtgtact   1680
tgtatccgga cattcccaaa gaggaggcgt tcgggaagta ctgtcgcccg gagtcacaag   1740
aacatcctga agctgaccca ggaagtgcag ctccgtacct taagaccaag tttatctgcg   1800
tgacaccgta agtggcttcc tttccccgtt ttgccttcat ttctaatatc ctcagttatc   1860
cctgggaatg ggacactggg tgagagttaa tctgccaaag gttggaagcc cctgggctat   1920
gtttagtact caaagtgacc ttgtgtgttt aaaaagcttg agcttttatt tttctgttgg   1980
agaccagagt ttgatggctt gtgtgtgtgt gttttgttct tttttttttt tccattgtgt   2040
cttgtcaacc ccccgtttcc cctcctgctg ccccccattt cctacagaac gacctgcagc   2100
aataccattg acctgccgat gtccccccgc actttagatt cattgatgca gtttggaaat   2160
aatggtgaag gtgctgaacc atccgctggt ggacagtttg agagccttac gtttgatatg   2220
gagttgacaa gcgagtgtgc tacatcacct atgtgagcag atccagacat gataagatac   2280
attgatgagt ttggacaaac cacaactaga atgcagtgaa aaaaatgctt tatttgtgaa   2340
atttgtgatg ctattgcttt atttgtaacc attataagct gcaataaaca agttaacaac   2400
aacaattgca ttcattttat gtttcaggtt cagggggagg tgtgggaggt tttttaaagc   2460
aagtaaaacc tctacaaatg tggtacggct tgattatgat catgactaaa gaatgtggtt   2520
agagacagtc tgaggaaatg ttttctgact ttgttttggt ttccaaccag agcatcgtga   2580
gtgagctggc ggggcttttg tcagcgatgg agtacgtgca gaaaactctc acggacgagg   2640
agctggctga ctggaagagg cggcaacaga ttgcctgcat tggaggcccg cccaacatct   2700
gcctagatcg gctagaaaac tggtaaagga tgaaagaagc ttttcctttc tttctcgaaa   2760
gctagattga attctgatct taactgcagg cccacagaat tggtactata tctccaacgt   2820
ggggactttt ccatattcaa atttagccca agaattaaag tttttacttt atttcggcca   2880
ggcgctgtgg ctcacacctg taatcccagc actttgggag a                       2921


<210>  43

<211>  2921
<212>  DNA
<213>  artificial

<220>
<223>  STAT3  DNA repair template intron 7 sequence 3

<400>  43
gtcaaggagt attccctcag gtcaaggagt tttttcttcc ttcgcagaca tgcaagatct     60
gaatggaaac aaccagtcag tgaccaggca gaagatgcag cagctggaac agatgctcac    120
tgcgctggac cagatgcgga gagtaagggc ataggtcgga ccacttcccc catgtgtctc    180
gctcacttgc gggatttcag cgtcttgtgg cagaacttgc ttggtttcta agaagttcct    240
gctctggagt tgatacaagc taggcccttt tgctaatcat gttcatactg tccctttttt    300
ttcctcagag catcgtgagt gagctggctg ggttgctttc agctatggaa tatgtgcaaa    360
agacgttgac agacgaggaa ctggccgact ggaagcggag gcaacaaatt gcttgcattg    420
gaggaccacc caatatatgc ctggatagat tggagaactg gataacgtca ttagcagaaa    480
gccaactgca aactagacag caaataaaga agctggaaga actccagcaa aaagtttcct    540
ataagggtga ccctatagtg cagcacaggc ccatgttgga ggaacgcatt gtggagttgt    600
ttagaaatct gatgaaaagt gcctttgtgg tggagcgaca accgtgcatg cctatgcacc    660
ctgaccggcc cttggtgata aagaccggag tacaattcac tactaaagtg aggctgctcg    720
taaagttccc tgaactcaat taccagttga agataaaagt gtgcatcgat aaggactccg    780
gcgatgttgc cgcgctccgg ggaagtcgaa agttcaacat cttgggcacc aatacaaagg    840
tgatgaacat ggaggaatca aacaacgggt ccctttccgc ggagttcaaa catttgacat    900
tgcgcgagca gagatgtggg aacgggggaa gagcaaattg tgacgcttct ctgatcgtaa    960
ctgaggagct gcatctcata acattcgaga ctgaggtcta ccatcaggga ttgaagatcg   1020
acctcgaaac tcattcactg cctgtagttg ttattagtaa tatttgccag atgccgaatg   1080
cgtgggctag catactttgg tataacatgc ttacgaataa tccaaagaac gttaattttt   1140
tcactaaacc tccaatcgga acttgggacc aggtcgcaga agtgctgagc tggcaatttt   1200
cctccaccac caaacgcggt cttagcatcg aacaattgac gaccctcgca gaaaagcttt   1260
tgggtcctgg cgttaattac tcagggtgtc agataacttg ggcaaagttc tgcaaagaaa   1320
acatggcagg caagggcttt tcattttggg tctggctgga taacattata gatttggtga   1380
aaaagtacat tcttgccctg tggaacgaag gctacatcat gggtttcatt agcaaggagc   1440
gcgagagagc gatcctgtca actaaacccc ctggaacgtt tctccttcgc ttttccgaaa   1500
gcagcaagga aggtggcgtg actttcacgt gggttgaaaa ggacatcagc ggaaagacgc   1560
aaattcagag cgttgaacct tacaccaagc agcaacttaa caacatgagc ttcgccgaga   1620
taataatggg ttacaaaata atggacgcta ctaatatcct cgtctcaccc ctcgtgtact   1680
tgtatccgga cattcccaaa gaggaggcgt tcgggaagta ctgtcgcccg gagtcacaag   1740
aacatcctga agctgaccca ggaagtgcag ctccgtacct taagaccaag tttatctgtg   1800
tgacaccgta agtggcttcc tttccccgtt ttgccttcat ttctaatatc ctcagttatc   1860
cctgggaatg ggacactggg tgagagttaa tctgccaaag gttggaagcc cctgggctat   1920
gtttagtact caaagtgacc ttgtgtgttt aaaaagcttg agcttttatt tttctgttgg   1980
agaccagagt ttgatggctt gtgtgtgtgt gttttgttct tttttttttt tccattgtgt   2040
cttgtcaacc ccccgtttcc cctcctgctg ccccccattt cctacagaac gacctgcagc   2100
aataccattg acctgccgat gtccccccgc actttagatt cattgatgca gtttggaaat   2160
aatggtgaag gtgctgaacc atccgctggt ggacagtttg agagccttac gtttgatatg   2220
gagttgacaa gcgagtgtgc tacatcacct atgtgagcag atccagacat gataagatac   2280
attgatgagt ttggacaaac cacaactaga atgcagtgaa aaaaatgctt tatttgtgaa   2340
atttgtgatg ctattgcttt atttgtaacc attataagct gcaataaaca agttaacaac   2400
aacaattgca ttcattttat gtttcaggtt cagggggagg tgtgggaggt tttttaaagc   2460
aagtaaaacc tctacaaatg tggtacggct tgattatgat catgactaaa gaatgtggtt   2520
agagacagtc tgaggaaatg ttttctgact ttgttttggt ttccaaccag agcatcgtga   2580
gtgagctggc ggggcttttg tcagcgatgg agtacgtgca gaaaactctc acggacgagg   2640
agctggctga ctggaagagg cggcaacaga ttgcctgcat tggaggcccg cccaacatct   2700
gcctagatcg gctagaaaac tggtaaagga tgaaagaagc ttttcctttc tttctcgaaa   2760
gctagattga attctgatct taactgcagg cccacagaat tggtactata tctccaacgt   2820
ggggactttt ccatattcaa atttagccca agaattaaag tttttacttt atttcggcca   2880
ggcgctgtgg ctcacacctg taatcccagc actttgggag a                       2921


<210>  44

<211>  2921
<212>  DNA
<213>  artificial

<220>
<223>  STAT3  DNA repair template intron 7 sequence 4

<400>  44
gtcaaggagt attccctcag gtcaaggagt tttttcttcc ttcgcagaca tgcaagatct     60
gaatggaaac aaccagtcag tgaccaggca gaagatgcag cagctggaac agatgctcac    120
tgcgctggac cagatgcgga gagtaagggc ataggtcgga ccacttcccc catgtgtctc    180
gctcacttgc gggatttcag cgtcttgtgg cagaacttgc ttggtttcta agaagttcct    240
gctctggagt tgatacaagc taggcccttt tgctaatcat gttcatactg tccctttttt    300
ttcctcagag catcgtgagt gagctggcgg ggcttttgtc agcgatggag tacgtgcaga    360
aaactctcac ggacgaggag ctggctgact ggaagaggcg gcaacagatt gcctgcattg    420
gaggcccgcc caacatctgc ctagatcggc tagaaaactg gataacgtca ttagcagaat    480
ctcaacttca gacccgtcaa caaattaaga aactggagga gttgcagcaa aaagtttcct    540
acaaagggga ccccattgta cagcaccggc cgatgctgga ggagagaatc gtggagctgt    600
ttagaaactt aatgaaaagc gcctttgtgg tggagcggca gccctgcatg cccatgcatc    660
ctgaccggcc cctcgtcatc aagaccggcg tccagttcac tactaaagtc agattgctgg    720
tcaaattccc tgagttgaat tatcagctta aaattaaagt gtgcattgac aaagactctg    780
gggacgttgc agctctcaga ggatcccgga agttcaacat cttgggcacc aacacaaaag    840
tgatgaacat ggaagaatcc aacaacggca gcctctctgc cgaattcaaa cacttgaccc    900
tgagggagca gagatgtggg aatgggggcc gagccaattg tgatgcttcc ctgattgtga    960
ctgaggagct gcacctgatc acctttgaga ccgaggtgta tcaccaaggc ctcaagattg   1020
acctagagac ccactccttg ccagttgtgg tgatctccaa catctgtcag atgccaaatg   1080
cctgggcgtc catcctgtgg tacaacatgc tgaccaacaa tcccaagaat gtaaactttt   1140
ttaccaagcc cccaattgga acctgggatc aagtggccga ggtcctgagc tggcagttct   1200
cctccaccac caagcgagga ctgagcatcg aacaattgac gaccctggca gagaaactct   1260
tgggacctgg tgtgaattat tcagggtgtc agatcacatg ggctaaattt tgcaaagaaa   1320
acatggctgg caagggcttc tccttctggg tctggctgga caatatcatt gaccttgtga   1380
aaaagtacat cctggccctt tggaacgaag gatacatcat gggctttatc agtaaggagc   1440
gggagagagc gatcctgtca actaaacctc caggcacctt cctgctaaga ttcagtgaaa   1500
gcagcaaaga aggaggcgtc actttcactt gggtggagaa ggacatcagc ggaaagacgc   1560
aaattcagag cgtggaacca tacacaaagc agcagctgaa caacatgtca tttgctgaaa   1620
tcatcatggg ctataagatc atggatgcta ccaatatcct ggtgtctcca ctggtctatc   1680
tctatccgga cattcccaaa gaggaggcgt tcggaaagta ctgtcgcccg gagtcacagg   1740
agcatcctga agctgaccca ggcagcgctg ccccatacct gaagaccaag tttatctgtg   1800
tgacaccgta agtggcttcc tttccccgtt ttgccttcat ttctaatatc ctcagttatc   1860
cctgggaatg ggacactggg tgagagttaa tctgccaaag gttggaagcc cctgggctat   1920
gtttagtact caaagtgacc ttgtgtgttt aaaaagcttg agcttttatt tttctgttgg   1980
agaccagagt ttgatggctt gtgtgtgtgt gttttgttct tttttttttt tccattgtgt   2040
cttgtcaacc ccccgtttcc cctcctgctg ccccccattt cctacagaac gacctgcagc   2100
aataccattg acctgccgat gtccccccgc actttagatt cattgatgca gtttggaaat   2160
aatggtgaag gtgctgaacc ctcagcagga ggacagtttg agagccttac gtttgatatg   2220
gagttgacct cggagtgcgc tacctccccc atgtgagcag atccagacat gataagatac   2280
attgatgagt ttggacaaac cacaactaga atgcagtgaa aaaaatgctt tatttgtgaa   2340
atttgtgatg ctattgcttt atttgtaacc attataagct gcaataaaca agttaacaac   2400
aacaattgca ttcattttat gtttcaggtt cagggggagg tgtgggaggt tttttaaagc   2460
aagtaaaacc tctacaaatg tggtacggct tgattatgat catgactaaa gaatgtggtt   2520
agagacagtc tgaggaaatg ttttctgact ttgttttggt ttccaaccag agcatcgtga   2580
gtgagctggc ggggcttttg tcagcgatgg agtacgtgca gaaaactctc acggacgagg   2640
agctggctga ctggaagagg cggcaacaga ttgcctgcat tggaggcccg cccaacatct   2700
gcctagatcg gctagaaaac tggtaaagga tgaaagaagc ttttcctttc tttctcgaaa   2760
gctagattga attctgatct taactgcagg cccacagaat tggtactata tctccaacgt   2820
ggggactttt ccatattcaa atttagccca agaattaaag tttttacttt atttcggcca   2880
ggcgctgtgg ctcacacctg taatcccagc actttgggag a                       2921


<210>  45

<211>  2921
<212>  DNA
<213>  artificial

<220>
<223>  STAT3  DNA repair template intron 7 sequence 5

<400>  45
gtcaaggagt attccctcag gtcaaggagt tttttcttcc ttcgcagaca tgcaagatct     60
gaatggaaac aaccagtcag tgaccaggca gaagatgcag cagctggaac agatgctcac    120
tgcgctggac cagatgcgga gagtaagggc ataggtcgga ccacttcccc catgtgtctc    180
gctcacttgc gggatttcag cgtcttgtgg cagaacttgc ttggtttcta agaagttcct    240
gctctggagt tgatacaagc taggcccttt tgctaatcat gttcatactg tccctttttt    300
ttcctcagag catcgtgagt gagctggctg ggttgctttc agctatggaa tatgtgcaaa    360
agacgttgac agacgaggaa ctggccgact ggaagcggag gcaacaaatt gcttgcattg    420
gaggaccacc caatatatgc ctggatagat tggagaactg gataacgtca ttagcagaaa    480
gccaactgca aactagacag caaataaaga agctggaaga actccagcaa aaagtttcct    540
ataagggtga ccctatagtg cagcacaggc ccatgttgga ggaacgcatt gtggagttgt    600
ttagaaatct gatgaaaagt gcctttgtgg tggagcgaca accgtgcatg cctatgcacc    660
ctgaccggcc cttggtgata aagaccggag tacaattcac tactaaagtg aggctgctcg    720
taaagttccc tgaactcaat taccagttga agataaaagt gtgcatcgat aaagactctg    780
gggacgttgc agctctcaga ggatcccgga agttcaacat cttgggcacc aacacaaaag    840
tgatgaacat ggaagaatcc aacaacggca gcctctctgc cgaattcaaa cacttgaccc    900
tgagggagca gagatgtggg aatgggggcc gagccaattg tgatgcttcc ctgattgtga    960
ctgaggagct gcacctgatc acctttgaga ccgaggtgta tcaccaaggc ctcaagattg   1020
acctagagac ccactccttg ccagttgtgg tgatctccaa catctgtcag atgccaaatg   1080
cctgggcgtc catcctgtgg tacaacatgc tgaccaacaa tcccaagaat gtaaactttt   1140
ttaccaagcc cccaattgga acctgggatc aagtggccga ggtcctgagc tggcagttct   1200
cctccaccac caagcgagga ctgagcatcg aacaattgac gaccctggca gagaaactct   1260
tgggacctgg tgtgaattat tcagggtgtc agatcacatg ggctaaattt tgcaaagaaa   1320
acatggctgg caagggcttc tccttctggg tctggctgga caatatcatt gaccttgtga   1380
aaaagtacat cctggccctt tggaacgaag gatacatcat gggctttatc agtaaggagc   1440
gggagagagc gatcctgtca actaaacctc caggcacctt cctgctaaga ttcagtgaaa   1500
gcagcaaaga aggaggcgtc actttcactt gggtggagaa ggacatcagc ggaaagacgc   1560
aaattcagag cgtggaacca tacacaaagc agcagctgaa caacatgtca tttgctgaaa   1620
tcatcatggg ctataagatc atggatgcta ccaatatcct ggtgtctcca ctggtctatc   1680
tctatccgga cattcccaaa gaggaggcgt tcggaaagta ctgtcgcccg gagtcacagg   1740
agcatcctga agctgaccca ggcagcgctg ccccatacct gaagaccaag tttatctgtg   1800
tgacaccgta agtggcttcc tttccccgtt ttgccttcat ttctaatatc ctcagttatc   1860
cctgggaatg ggacactggg tgagagttaa tctgccaaag gttggaagcc cctgggctat   1920
gtttagtact caaagtgacc ttgtgtgttt aaaaagcttg agcttttatt tttctgttgg   1980
agaccagagt ttgatggctt gtgtgtgtgt gttttgttct tttttttttt tccattgtgt   2040
cttgtcaacc ccccgtttcc cctcctgctg ccccccattt cctacagaac gacctgcagc   2100
aataccattg acctgccgat gtccccccgc actttagatt cattgatgca gtttggaaat   2160
aatggtgaag gtgctgaacc ctcagcagga ggacagtttg agagccttac gtttgatatg   2220
gagttgacct cggagtgcgc tacctccccc atgtgagcag atccagacat gataagatac   2280
attgatgagt ttggacaaac cacaactaga atgcagtgaa aaaaatgctt tatttgtgaa   2340
atttgtgatg ctattgcttt atttgtaacc attataagct gcaataaaca agttaacaac   2400
aacaattgca ttcattttat gtttcaggtt cagggggagg tgtgggaggt tttttaaagc   2460
aagtaaaacc tctacaaatg tggtacggct tgattatgat catgactaaa gaatgtggtt   2520
agagacagtc tgaggaaatg ttttctgact ttgttttggt ttccaaccag agcatcgtga   2580
gtgagctggc ggggcttttg tcagcgatgg agtacgtgca gaaaactctc acggacgagg   2640
agctggctga ctggaagagg cggcaacaga ttgcctgcat tggaggcccg cccaacatct   2700
gcctagatcg gctagaaaac tggtaaagga tgaaagaagc ttttcctttc tttctcgaaa   2760
gctagattga attctgatct taactgcagg cccacagaat tggtactata tctccaacgt   2820
ggggactttt ccatattcaa atttagccca agaattaaag tttttacttt atttcggcca   2880
ggcgctgtgg ctcacacctg taatcccagc actttgggag a                       2921


<210>  46

<211>  246
<212>  DNA
<213>  artificial

<220>
<223>  SV40polyA

<400>  46
gcagatccag acatgataag atacattgat gagtttggac aaaccacaac tagaatgcag     60
tgaaaaaaat gctttatttg tgaaatttgt gatgctattg ctttatttgt aaccattata    120
agctgcaata aacaagttaa caacaacaat tgcattcatt ttatgtttca ggttcagggg    180
gaggtgtggg aggtttttta aagcaagtaa aacctctaca aatgtggtac ggcttgatta    240
tgatca                                                               246


<210>  47

<211>  2791
<212>  DNA
<213>  artificial

<220>
<223>  STAT3  DNA repair template intron 9 sequence

<400>  47
gtctccatgt cttcagtatt tccttcccct tctccatctc acctgtatac attcactttg     60
gtaattagca tctttcttaa tttattggca ggataacgtc attagcagaa tctcaacttc    120
agacccgtca acaaattaag aaactggagg agttgcagca aaaagtttcc tacaaagggg    180
accccattgt acagcaccgg ccgatgctgg aggagagaat cgtggagctg tttagaaact    240
taatgaaaag gtaatttagc atccttgtcc ctttccctca tctaaaaaat acctaaagac    300
tcacgtggta gagtgagagg cgggctgact tctggtcatg gccgtggcgt gatacaagct    360
aggccctttt gctaatcatg ttcatactgt cccttttttt tccacagtgc ctttgtggtg    420
gagcgacaac cgtgcatgcc tatgcaccct gaccggccct tggtgataaa gaccggagta    480
caattcacta ctaaagtgag gctgctcgta aagttccctg aactcaatta ccagttgaag    540
ataaaagtgt gcatcgataa ggactccggc gatgttgccg cgctccgggg aagtcgaaag    600
ttcaacatct tgggcaccaa tacaaaggtg atgaacatgg aggaatcaaa caacgggtcc    660
ctttccgcgg agttcaaaca tttgacattg cgcgagcaga gatgtgggaa cgggggaaga    720
gcaaattgtg acgcttctct gatcgtaact gaggagctgc atctcataac attcgagact    780
gaggtctacc atcagggatt gaagatcgac ctcgaaactc attcactgcc tgtagttgtt    840
attagtaata tttgccagat gccgaatgcg tgggctagca tactttggta taacatgctt    900
acgaataatc caaagaacgt taattttttc actaaacctc caatcggaac ttgggaccag    960
gtcgcagaag tgctgagctg gcaattttcc tccaccacca aacgcggtct tagcatcgaa   1020
caattgacga ccctcgcaga aaagcttttg ggtcctggcg ttaattactc agggtgtcag   1080
ataacttggg caaagttctg caaagaaaac atggcaggta agggcttttc attttgggtc   1140
tggctggata acattataga tttggtgaaa aagtacattc ttgccctgtg gaacgaaggc   1200
tacatcatgg gtttcattag caaggagcgc gagagagcga tcctgtcaac taaaccccct   1260
ggaacgtttc tccttagatt ttccgaaagc agcaaggaag gtggcgtgac tttcacgtgg   1320
gttgaaaagg acatcagcgg aaagacgcaa attcagagcg ttgaacctta caccaagcag   1380
caacttaaca acatgagctt cgccgagata ataatgggtt acaaaataat ggacgctact   1440
aatatcctcg tctcacccct cgtgtacttg tatccagaca ttcccaaaga ggaggcgttc   1500
gggaagtact gtcgcccgga gtcacaagaa catcctgaag ctgacccagg aagtgcagct   1560
ccgtacctta agaccaagtt tatctgtgtg acaccgtaag tggcttcctt tccccgtttt   1620
gccttcattt ctaatatcct cagttatccc tgggaatggg acactgggtg agagttaatc   1680
tgccaaaggt tggaagcccc tgggctatgt ttagtactca aagtgacctt gtgtgtttaa   1740
aaagcttgag cttttatttt tctgttggaa gaccagagtt tgatggcttg tgtgtgtgtg   1800
ttttgttctt tttttttttt ccattgtgtc ttgtcaaccc cccgtttccc ctcctgctgc   1860
cccccatttc ctacagaacg acctgcagca ataccattga cctgccgatg tccccccgca   1920
ctttagattc attgatgcag tttggaaata atggtgaagg tgctgaacca tccgctggtg   1980
gacagtttga gagccttacg tttgatatgg agttgacaag cgagtgtgct acatcaccta   2040
tgtgagcaga tccagacatg ataagataca ttgatgagtt tggacaaacc acaactagaa   2100
tgcagtgaaa aaaatgcttt atttgtgaaa tttgtgatgc tattgcttta tttgtaacca   2160
ttataagctg caataaacaa gttaacaaca acaattgcat tcattttatg tttcaggttc   2220
agggggaggt gtgggaggtt ttttaaagca agtaaaacct ctacaaatgt ggtacggctt   2280
gattatgatc acgtgagccc atcttctctt tcctcagtgc ctttgtggtg gagcggcagc   2340
cctgcatgcc catgcatcct gaccggcccc tcgtcatcaa gaccggcgtc cagttcacta   2400
ctaaagtcag gtaggccatg ccacttccat ttccagtaga gattttactg agggacactg   2460
ttagggtgag ggtagagttg gtggccaggg tcattctttc caggtgtggt gtcacaggca   2520
gtacactgtt gcggggttga aatttgttgc catactatct gcttgctctc tgattctgat   2580
gtcaaaagca aaagagcagt catctttttg aaggtacctg ggcatattcc tatgattgta   2640
gacctggagt ctcaggccac agcttctcct tctgcccaag ggacaaaata atgtcatcta   2700
ttttctgttc tttgaggcta ctcttccctg tggattttaa gggaaagagt aaggcttagt   2760
gatggggaag ctgagaggcc ccagggcagg t                                  2791


<210>  48

<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  oligo 2628

<400>  48
agtcagtgac caggcagaag                                                 20


<210>  49

<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  oligo 2852

<400>  49
cagttttcta gccgatctag gcag                                            24


<210>  50

<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  oligo 4961

<400>  50
ctcttcatgc aaggggatgc                                                 20


<210>  51

<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  oligo 5029

<400>  51
ccaccaccac tcccggataa                                                 20


<210>  52

<211>  28
<212>  DNA
<213>  artificial

<220>
<223>  oligo 3036

<400>  52
cttctccatc tcacctgtat acattcac                                        28


<210>  53

<211>  21
<212>  DNA
<213>  artificial

<220>
<223>  oligo 4206

<400>  53
agaatgaccc tggccaccaa c                                               21


<210>  54

<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  oligo 2629

<400>  54
tttctgcacg tactccatcg                                                 20


<210>  55

<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  oligo 5480

<400>  55
catatctggg ctcagatgct tgtc                                            24


<210>  56

<211>  21
<212>  DNA
<213>  artificial

<220>
<223>  oligo 5482

<400>  56
tcaacttcag acccgtcaac a                                               21


<210>  57

<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  oligo 5483

<400>  57
aactggacgc cggtcttgat                                                 20


<210>  58

<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  oligo 4963

<400>  58
tgacattccc aaggaggagg                                                 20


<210>  59

<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  oligo 5037

<400>  59
caaaggtgag ggactcaaac tg                                              22


<210>  60

<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  oligo 5325

<400>  60
agtactgtcg cccggagtca                                                 20


<210>  61

<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  oligo 5326

<400>  61
tcaaacgtaa ggctctcaaa ctgt                                            24


<210>  62

<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  oligo 5526

<400>  62
aaggagcctg gtcattaagg                                                 20


<210>  63

<211>  23
<212>  DNA
<213>  artificial

<220>
<223>  oligo 5728

<400>  63
catgattagc aaaagggcct agc                                             23


<210>  64

<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  oligo 5729

<400>  64
cctctacaaa tgtggtacgg cttg                                            24


<210>  65

<211>  19
<212>  DNA
<213>  artificial

<220>
<223>  oligo 5722

<400>  65
tgatccgccc atcttggtc                                                  19


<210>  66

<211>  25
<212>  DNA
<213>  artificial

<220>
<223>  oligo 5726

<400>  66
ccttgttctt attgtagtgg tctcc                                           25


<210>  67

<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  oligo 5725

<400>  67
cctgagcctc ctgagagatt ac                                              22


<210>  68

<211>  19
<212>  DNA
<213>  artificial

<220>
<223>  oligo 5341

<400>  68
aacacatgct gtgcagctg                                                  19


<210>  69

<211>  23
<212>  DNA
<213>  artificial

<220>
<223>  oligo 5730

<400>  69
cttgggcaac ataacaagac acc                                             23


<210>  70

<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  oligo 5485

<400>  70
tggctgcagt ctgtagaagg                                                 20


<210>  71

<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  oligo 3035

<400>  71
tggagtctgg ctgtagccca                                                 20


<210>  72

<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  oligo 4025

<400>  72
gtcctgtttc tccttgtcct cagt                                            24


<210>  73

<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  oligo 4965

<400>  73
attgctgcag gtcgttggtg                                                 20


<210>  74

<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  oligo 4964

<400>  74
tccaaactgc atcaatgaat ggtg                                            24


<210>  75

<211>  19
<212>  DNA
<213>  artificial

<220>
<223>  oligo 4428

<400>  75
cttcgattcg ggaccagcc                                                  19


<210>  76

<211>  17
<212>  DNA
<213>  artificial

<220>
<223>  oligo 4429

<400>  76
cggagccagc gtggatc                                                    17


<210>  77

<211>  18
<212>  DNA
<213>  artificial

<220>
<223>  oligo 4406

<400>  77
ccctggcgtc gtgattag                                                   18


<210>  78

<211>  23
<212>  DNA
<213>  artificial

<220>
<223>  oligo 4407

<400>  78
catgaggaat aaacaccctt tcc                                             23


