                         SEQUENCE LISTING

<110>  Aptevo Research and Development LLC
       Uckun, Fatih
       Stromatt, Scott
        
<120>  DOSING REGIMENS FOR PROTEIN THERAPEUTICS

<130>  APVO-069/02WO 327714-2790

<150>  US 63/253,714
<151>  2021-10-08

<150>  US 63/191,488
<151>  2021-05-21

<160>  390   

<170>  PatentIn version 3.5

<210>  1

<400>  1
000

<210>  2

<400>  2
000

<210>  3

<400>  3
000

<210>  4

<400>  4
000

<210>  5

<400>  5
000

<210>  6

<400>  6
000

<210>  7

<400>  7
000

<210>  8

<400>  8
000

<210>  9

<400>  9
000

<210>  10
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD123 HCDR1

<400>  10

Gly Phe Thr Phe Ser Ser Tyr Gly 
1               5               


<210>  11
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD123 HCDR2

<400>  11

Ile Ser Gly Ser Gly Gly Ser Thr 
1               5               


<210>  12
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD123 HCDR3

<400>  12

Ala Lys Glu Lys Leu Arg Tyr Phe Asp Trp Leu Ser Asp Ala Phe Asp 
1               5                   10                  15      


Ile 
    


<210>  13
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD123 LCDR1

<400>  13

His Ser Val Leu Tyr Ser Ser Asn Asn Lys Asn Tyr 
1               5                   10          


<210>  14
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD123 LCDR2

<400>  14

Trp Ala Ser 
1           


<210>  15
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD123 LCDR3

<400>  15

Gln Gln Tyr Tyr Ser Thr Pro Pro Thr Thr 
1               5                   10  


<210>  16
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD123 VH

<400>  16

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser His Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Thr Pro Pro Thr Thr Phe Gly Gly Gly Thr Lys Val Glu 
            100                 105                 110         


Ile Lys 
        


<210>  17
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD123 VL

<400>  17

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Glu Lys Leu Arg Tyr Phe Asp Trp Leu Ser Asp Ala Phe Asp 
            100                 105                 110         


Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 


<210>  18
<211>  258
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD123 scFv

<400>  18

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser His Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Thr Pro Pro Thr Thr Phe Gly Gly Gly Thr Lys Val Glu 
            100                 105                 110         


Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly 
    130                 135                 140                 


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
145                 150                 155                 160 


Phe Thr Phe Ser Ser Tyr Gly Met Ser Trp Val Arg Gln Ala Pro Gly 
                165                 170                 175     


Lys Gly Leu Glu Gly Val Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr 
            180                 185                 190         


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
        195                 200                 205             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    210                 215                 220                 


Thr Ala Val Tyr Tyr Cys Ala Lys Glu Lys Leu Arg Tyr Phe Asp Trp 
225                 230                 235                 240 


Leu Ser Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val 
                245                 250                 255     


Ser Ser 
        


<210>  19
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3epsilon HCDR1

<400>  19

Gly Tyr Thr Phe Ser Arg Ser Thr 
1               5               


<210>  20
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3epsilon HCDR2

<400>  20

Ile Asn Pro Ser Ser Ala Tyr Thr 
1               5               


<210>  21
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3epsilon HCDR3

<400>  21

Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr 
1               5                   10                  


<210>  22
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3epsilon LCDR1

<400>  22

Ala Ser Ser Ser Val Ser Tyr 
1               5           


<210>  23
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3epsilon LCDR2

<400>  23

Asp Ser Ser 
1           


<210>  24
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3epsilon LCDR3

<400>  24

Gln Gln Trp Ser Arg Asn Pro Pro Thr 
1               5                   


<210>  25
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3epsilon VH

<400>  25

Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Arg Ser 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  26
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3epsilon VL

<400>  26

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Ser Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Ser 
            100                 105             


<210>  27
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3epsilon scFv

<400>  27

Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Arg Ser 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln 
    130                 135                 140                 


Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val 
145                 150                 155                 160 


Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser 
            180                 185                 190         


Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys Arg Ser 
                245                 


<210>  28

<400>  28
000

<210>  29

<400>  29
000

<210>  30

<400>  30
000

<210>  31
<211>  777
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD123 x anti-CD3epsilon bispecific construct amino acid
       sequence

<400>  31

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala 
            20                  25                  30          


Val Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser His Ser 
        35                  40                  45              


Val Leu Tyr Ser Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg 
65                  70                  75                  80  


Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr 
            100                 105                 110         


Tyr Cys Gln Gln Tyr Tyr Ser Thr Pro Pro Thr Thr Phe Gly Gly Gly 
        115                 120                 125             


Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu 
145                 150                 155                 160 


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
                165                 170                 175     


Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Gly Met Ser Trp Val Arg 
            180                 185                 190         


Gln Ala Pro Gly Lys Gly Leu Glu Gly Val Ser Ala Ile Ser Gly Ser 
        195                 200                 205             


Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Glu Lys Leu Arg 
                245                 250                 255     


Tyr Phe Asp Trp Leu Ser Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr 
            260                 265                 270         


Met Val Thr Val Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
        275                 280                 285             


Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val 
    290                 295                 300                 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
305                 310                 315                 320 


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
                325                 330                 335     


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
            340                 345                 350         


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
        355                 360                 365             


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
    370                 375                 380                 


Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
385                 390                 395                 400 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
                405                 410                 415     


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
            420                 425                 430         


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
        435                 440                 445             


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
    450                 455                 460                 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
465                 470                 475                 480 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
                485                 490                 495     


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Ser Gly 
            500                 505                 510         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Pro Ser 
        515                 520                 525             


Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ser 
    530                 535                 540                 


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Arg Ser 
545                 550                 555                 560 


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
                565                 570                 575     


Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe 
            580                 585                 590         


Lys Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
        595                 600                 605             


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
    610                 615                 620                 


Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly 
625                 630                 635                 640 


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                645                 650                 655     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln 
            660                 665                 670         


Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val 
        675                 680                 685             


Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr 
    690                 695                 700                 


Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser 
705                 710                 715                 720 


Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
                725                 730                 735     


Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala 
            740                 745                 750         


Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly 
        755                 760                 765             


Gly Thr Lys Val Glu Ile Lys Arg Ser 
    770                 775         


<210>  32
<211>  699
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  modified immunoglobulin constant region

<400>  32
tcgagtgagc ccaaatcttc tgacaaaact cacacatgcc caccgtgccc agcacctgaa       60

gccgcgggtg caccgtcagt cttcctcttc cccccaaaac ccaaggacac cctcatgatc      120

tcccggaccc ctgaggtcac atgcgtggtg gtggacgtga gccacgaaga ccctgaggtc      180

aagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccgcgggag      240

gagcagtaca acagcacgta ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg      300

ctgaatggca aggaatacaa gtgcgcggtc tccaacaaag ccctcccagc ccccatcgag      360

aaaaccatct ccaaagccaa agggcagccc cgagaaccac aggtgtacac cctgccccca      420

tcccgggatg agctgaccaa gaaccaggtc agcctgacct gcctggtcaa aggcttctat      480

ccaagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc      540

acgcctcccg tgctggactc cgacggctcc ttcttcctct acagcaagct caccgtggac      600

aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga ggctctgcac      660

aaccactaca cgcagaagag cctctccctg tctccgggt                             699


<210>  33
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  modified immunoglobulin constant region

<400>  33

Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys 
1               5                   10                  15      


Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro Pro 
            20                  25                  30          


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
        35                  40                  45              


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
    50                  55                  60                  


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
65                  70                  75                  80  


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
                85                  90                  95      


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn 
            100                 105                 110         


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
        115                 120                 125             


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
    130                 135                 140                 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
145                 150                 155                 160 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
                165                 170                 175     


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
            180                 185                 190         


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
        195                 200                 205             


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
    210                 215                 220                 


Gln Lys Ser Leu Ser Leu Ser Pro Gly 
225                 230             


<210>  34
<211>  693
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  modified immunoglobulin constant region

<400>  34
gagcccaaat cttctgacaa aactcacaca tgcccaccgt gcccagcacc tgaagccgcg       60

ggtgcaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      120

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      180

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      240

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      300

ggcaaggaat acaagtgcgc ggtctccaac aaagccctcc cagcccccat cgagaaaacc      360

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg      420

gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatccaagc      480

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      540

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc      600

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac      660

tacacgcaga agagcctctc cctgtctccg ggt                                   693


<210>  35
<211>  231
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  modified immunoglobulin constant region

<400>  35

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly 
225                 230     


<210>  36
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  immunoglobulin hinge region

<400>  36

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser Ser 
1               5                   10                  15  


<210>  37
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  immunoglobulin hinge region

<400>  37

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Cys Ser 
1               5                   10                  15  


<210>  38
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  immunoglobulin hinge region

<400>  38

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Cys Ser 
1               5                   10                  15  


<210>  39
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  immunoglobulin hinge region

<400>  39

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Ser 
1               5                   10                  15  


<210>  40
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  immunoglobulin hinge region

<400>  40

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Ser Ser 
1               5                   10                  15  


<210>  41
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  immunoglobulin hinge region

<400>  41

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Ser Ser 
1               5                   10                  15  


<210>  42
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  immunoglobulin hinge region

<400>  42

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Cys Ser 
1               5                   10                  15  


<210>  43
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  immunoglobulin hinge region

<400>  43

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Cys Pro 
1               5                   10                  15  


<210>  44
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  immunoglobulin hinge region

<400>  44

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser Pro 
1               5                   10                  15  


<210>  45
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  immunoglobulin hinge region

<400>  45

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Cys Pro 
1               5                   10                  15  


<210>  46
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  immunoglobulin hinge region

<400>  46

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Cys Pro 
1               5                   10                  15  


<210>  47
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  immunoglobulin hinge region

<400>  47

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  48
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  immunoglobulin hinge region

<400>  48

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Ser Pro 
1               5                   10                  15  


<210>  49
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  immunoglobulin hinge region

<400>  49

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Ser Pro 
1               5                   10                  15  


<210>  50
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Fc binding domain linker

<400>  50

Ser Cys Pro Pro Cys Pro 
1               5       


<210>  51
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Fc binding domain linker

<400>  51

Asn Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Asn Ser 
            20  


<210>  52
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Fc binding domain linker

<400>  52

Asn Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Asn Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Asn Ser 
        35              


<210>  53
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Fc binding domain linker

<400>  53

Gly Gly Gly Gly Ser Gly Asn Ser 
1               5               


<210>  54
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Fc binding domain linker

<400>  54

Asn Tyr Gly Gly Gly Gly Ser Gly Asn Ser 
1               5                   10  


<210>  55
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Fc binding domain linker

<400>  55

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Asn Ser 
1               5                   10              


<210>  56
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Fc binding domain linker

<400>  56

Asn Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Asn Ser 
1               5                   10                  15  


<210>  57
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Fc binding domain linker

<400>  57

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Asn Ser 
        


<210>  58
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Fc binding domain linker

<400>  58

Gly Cys Pro Pro Cys Pro Asn Ser 
1               5               


<210>  59
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Fc binding domain linker

<400>  59

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  60
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Fc binding domain linker

<400>  60

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


<210>  61
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Fc binding domain linker

<400>  61

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  62
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Fc binding domain linker

<400>  62

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25  


<210>  63
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Fc binding domain linker

<400>  63

Gln Arg His Asn Asn Ser Ser Leu Asn Thr Gly Thr Gln Met Ala Gly 
1               5                   10                  15      


His Ser Pro Asn Ser 
            20      


<210>  64
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Fc binding domain linker

<400>  64

Ser Ser Leu Asn Thr Gly Thr Gln Met Ala Gly His Ser Pro Asn Ser 
1               5                   10                  15      


<210>  65
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Fc binding domain linker

<400>  65

Gln Arg His Asn Asn Ser Ser Leu Asn Thr Gly Thr Gln Met Ala Gly 
1               5                   10                  15      


His Ser 
        


<210>  66
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Fc binding domain linker

<400>  66

Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr Ser Pro Asn Ser 
1               5                   10                  


<210>  67
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Fc binding domain linker

<400>  67

Asn Ser Leu Ala Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr 
1               5                   10                  15      


Ser Pro Asn Ser 
            20  


<210>  68
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Fc binding domain linker

<400>  68

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


Pro Asn Ser 
            


<210>  69
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Fc binding domain linker

<400>  69

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


Pro Gly Ser 
            


<210>  70
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Fc binding domain linker

<400>  70

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Pro 
1               5                   10                  15      


Ser 
    


<210>  71

<400>  71
000

<210>  72

<400>  72
000

<210>  73

<400>  73
000

<210>  74

<400>  74
000

<210>  75

<400>  75
000

<210>  76

<400>  76
000

<210>  77

<400>  77
000

<210>  78

<400>  78
000

<210>  79

<400>  79
000

<210>  80

<400>  80
000

<210>  81

<400>  81
000

<210>  82

<400>  82
000

<210>  83

<400>  83
000

<210>  84

<400>  84
000

<210>  85

<400>  85
000

<210>  86

<400>  86
000

<210>  87

<400>  87
000

<210>  88

<400>  88
000

<210>  89

<400>  89
000

<210>  90

<400>  90
000

<210>  91

<400>  91
000

<210>  92

<400>  92
000

<210>  93

<400>  93
000

<210>  94

<400>  94
000

<210>  95

<400>  95
000

<210>  96

<400>  96
000

<210>  97

<400>  97
000

<210>  98

<400>  98
000

<210>  99

<400>  99
000

<210>  100

<400>  100
000

<210>  101

<400>  101
000

<210>  102

<400>  102
000

<210>  103

<400>  103
000

<210>  104

<400>  104
000

<210>  105

<400>  105
000

<210>  106

<400>  106
000

<210>  107

<400>  107
000

<210>  108

<400>  108
000

<210>  109

<400>  109
000

<210>  110
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 LCDR1

<400>  110

Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn 
1               5                   10                  


<210>  111
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 LCDR1

<400>  111

Arg Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn 
1               5                   10                  


<210>  112
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 LCDR1

<400>  112

Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn 
1               5                   10                  


<210>  113
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 LCDR2

<400>  113

Gly Thr Lys Phe Leu Ala Pro 
1               5           


<210>  114
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 LCDR2

<400>  114

Ala Thr Asp Met Arg Pro Ser 
1               5           


<210>  115
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 LCDR2

<400>  115

Gly Thr Lys Phe Leu Ala Pro 
1               5           


<210>  116
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 LCDR3

<400>  116

Ala Leu Trp Tyr Ser Asn Arg Trp Val 
1               5                   


<210>  117
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 LCDR3

<400>  117

Ala Leu Trp Tyr Ser Asn Arg Trp Val 
1               5                   


<210>  118
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 LCDR3

<400>  118

Val Leu Trp Tyr Ser Asn Arg Trp Val 
1               5                   


<210>  119
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 HCDR1

<400>  119

Ile Tyr Ala Met Asn 
1               5   


<210>  120
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 HCDR1

<400>  120

Lys Tyr Ala Met Asn 
1               5   


<210>  121
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 HCDR1

<400>  121

Ser Tyr Ala Met Asn 
1               5   


<210>  122
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 HCDR2

<400>  122

Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Ser 
            


<210>  123
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 HCDR2

<400>  123

Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210>  124
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 HCDR2

<400>  124

Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  125
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 HCDR3

<400>  125

His Gly Asn Phe Gly Asn Ser Tyr Val Ser Phe Phe Ala Tyr 
1               5                   10                  


<210>  126
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 HCDR3

<400>  126

His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr 
1               5                   10                  


<210>  127
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 HCDR3

<400>  127

His Gly Asn Phe Gly Asn Ser Tyr Leu Ser Phe Trp Ala Tyr 
1               5                   10                  


<210>  128
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  peptide linker

<400>  128

Gly Gly Gly Gly Ser 
1               5   


<210>  129
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  peptide linker


<220>
<221>  MISC_FEATURE
<222>  (6)..(10)
<223>  may be present or absent

<220>
<221>  MISC_FEATURE
<222>  (11)..(15)
<223>  may be present or absent

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  may be present or absent

<220>
<221>  MISC_FEATURE
<222>  (21)..(25)
<223>  may be present or absent
<400>  129

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25  


<210>  130

<400>  130
000

<210>  131
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Modified immunoglobulin constant region

<400>  131

Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys Ala Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            100                 105                 110         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        115                 120                 125             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    130                 135                 140                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
145                 150                 155                 160 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                165                 170                 175     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            180                 185                 190         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        195                 200                 205             


Lys Ser Leu Ser Leu Ser Pro Gly 
    210                 215     


<210>  132
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Fc binding domain linker

<400>  132

Ser Ser Leu Asn Thr Gly Thr Gln Pro Asn Ser 
1               5                   10      


<210>  133
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  OMT1 variable light chain domain

<400>  133
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca cagtgtttta tacagctcca acaataagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtcagcaata ttatagtact      300

cctccgacca ctttcggcgg agggaccaag gtggagatca aa                         342


<210>  134
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  OMT1 variable light chain domain

<400>  134

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser His Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Thr Pro Pro Thr Thr Phe Gly Gly Gly Thr Lys Val Glu 
            100                 105                 110         


Ile Lys 
        


<210>  135
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  OMT1 variable heavy chain domain

<400>  135
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagc agctatggca tgagctgggt ccgccaggct      120

ccagggaagg ggctggaggg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagaaaag      300

ttacgatatt ttgactggtt atccgatgct tttgatatct ggggccaagg gacaatggtc      360

accgtctctt ca                                                          372


<210>  136
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  OMT1 variable heavy chain domain

<400>  136

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Glu Lys Leu Arg Tyr Phe Asp Trp Leu Ser Asp Ala Phe Asp 
            100                 105                 110         


Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 


<210>  137
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  OMT1 CDRL1

<400>  137
cacagtgttt tatacagctc caacaataag aactac                                 36


<210>  138
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  OMT1 CDRL1

<400>  138

His Ser Val Leu Tyr Ser Ser Asn Asn Lys Asn Tyr 
1               5                   10          


<210>  139
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  OMT1 CDRL2

<400>  139
tgggcatct                                                                9


<210>  140
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  OMT1 CDRL2

<400>  140

Trp Ala Ser 
1           


<210>  141
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  OMT1 CDRL3

<400>  141
cagcaatatt atagtactcc tccgaccact                                        30


<210>  142
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  OMT1 CDRL3

<400>  142

Gln Gln Tyr Tyr Ser Thr Pro Pro Thr Thr 
1               5                   10  


<210>  143
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  OMT1 CDRH1

<400>  143
ggattcacct ttagcagcta tggc                                              24


<210>  144
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  OMT1 CDRH1

<400>  144

Gly Phe Thr Phe Ser Ser Tyr Gly 
1               5               


<210>  145
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  OMT1 CDRH2

<400>  145
attagtggta gtggtggtag caca                                              24


<210>  146
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  OMT1 CDRH2

<400>  146

Ile Ser Gly Ser Gly Gly Ser Thr 
1               5               


<210>  147
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  OMT1 CDRH3

<400>  147
gcgaaagaaa agttacgata ttttgactgg ttatccgatg cttttgatat c                51


<210>  148
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  OMT1 CDRH3

<400>  148

Ala Lys Glu Lys Leu Arg Tyr Phe Asp Trp Leu Ser Asp Ala Phe Asp 
1               5                   10                  15      


Ile 
    


<210>  149

<400>  149
000

<210>  150

<400>  150
000

<210>  151

<400>  151
000

<210>  152

<400>  152
000

<210>  153

<400>  153
000

<210>  154

<400>  154
000

<210>  155

<400>  155
000

<210>  156

<400>  156
000

<210>  157

<400>  157
000

<210>  158

<400>  158
000

<210>  159

<400>  159
000

<210>  160

<400>  160
000

<210>  161

<400>  161
000

<210>  162

<400>  162
000

<210>  163

<400>  163
000

<210>  164

<400>  164
000

<210>  165

<400>  165
000

<210>  166

<400>  166
000

<210>  167

<400>  167
000

<210>  168

<400>  168
000

<210>  169

<400>  169
000

<210>  170

<400>  170
000

<210>  171

<400>  171
000

<210>  172

<400>  172
000

<210>  173

<400>  173
000

<210>  174

<400>  174
000

<210>  175

<400>  175
000

<210>  176

<400>  176
000

<210>  177

<400>  177
000

<210>  178

<400>  178
000

<210>  179

<400>  179
000

<210>  180

<400>  180
000

<210>  181

<400>  181
000

<210>  182

<400>  182
000

<210>  183

<400>  183
000

<210>  184

<400>  184
000

<210>  185

<400>  185
000

<210>  186

<400>  186
000

<210>  187

<400>  187
000

<210>  188

<400>  188
000

<210>  189

<400>  189
000

<210>  190

<400>  190
000

<210>  191

<400>  191
000

<210>  192

<400>  192
000

<210>  193

<400>  193
000

<210>  194

<400>  194
000

<210>  195

<400>  195
000

<210>  196

<400>  196
000

<210>  197

<400>  197
000

<210>  198

<400>  198
000

<210>  199

<400>  199
000

<210>  200

<400>  200
000

<210>  201

<400>  201
000

<210>  202

<400>  202
000

<210>  203

<400>  203
000

<210>  204

<400>  204
000

<210>  205

<400>  205
000

<210>  206

<400>  206
000

<210>  207

<400>  207
000

<210>  208

<400>  208
000

<210>  209

<400>  209
000

<210>  210

<400>  210
000

<210>  211

<400>  211
000

<210>  212

<400>  212
000

<210>  213

<400>  213
000

<210>  214

<400>  214
000

<210>  215

<400>  215
000

<210>  216

<400>  216
000

<210>  217

<400>  217
000

<210>  218

<400>  218
000

<210>  219

<400>  219
000

<210>  220

<400>  220
000

<210>  221

<400>  221
000

<210>  222

<400>  222
000

<210>  223

<400>  223
000

<210>  224

<400>  224
000

<210>  225

<400>  225
000

<210>  226

<400>  226
000

<210>  227

<400>  227
000

<210>  228

<400>  228
000

<210>  229

<400>  229
000

<210>  230

<400>  230
000

<210>  231

<400>  231
000

<210>  232

<400>  232
000

<210>  233

<400>  233
000

<210>  234

<400>  234
000

<210>  235

<400>  235
000

<210>  236

<400>  236
000

<210>  237

<400>  237
000

<210>  238

<400>  238
000

<210>  239

<400>  239
000

<210>  240

<400>  240
000

<210>  241

<400>  241
000

<210>  242

<400>  242
000

<210>  243

<400>  243
000

<210>  244

<400>  244
000

<210>  245

<400>  245
000

<210>  246

<400>  246
000

<210>  247

<400>  247
000

<210>  248

<400>  248
000

<210>  249

<400>  249
000

<210>  250

<400>  250
000

<210>  251

<400>  251
000

<210>  252

<400>  252
000

<210>  253

<400>  253
000

<210>  254

<400>  254
000

<210>  255

<400>  255
000

<210>  256

<400>  256
000

<210>  257

<400>  257
000

<210>  258

<400>  258
000

<210>  259

<400>  259
000

<210>  260

<400>  260
000

<210>  261

<400>  261
000

<210>  262

<400>  262
000

<210>  263

<400>  263
000

<210>  264

<400>  264
000

<210>  265

<400>  265
000

<210>  266

<400>  266
000

<210>  267

<400>  267
000

<210>  268

<400>  268
000

<210>  269

<400>  269
000

<210>  270

<400>  270
000

<210>  271

<400>  271
000

<210>  272

<400>  272
000

<210>  273

<400>  273
000

<210>  274

<400>  274
000

<210>  275

<400>  275
000

<210>  276

<400>  276
000

<210>  277

<400>  277
000

<210>  278

<400>  278
000

<210>  279

<400>  279
000

<210>  280

<400>  280
000

<210>  281

<400>  281
000

<210>  282

<400>  282
000

<210>  283

<400>  283
000

<210>  284

<400>  284
000

<210>  285

<400>  285
000

<210>  286

<400>  286
000

<210>  287

<400>  287
000

<210>  288

<400>  288
000

<210>  289

<400>  289
000

<210>  290

<400>  290
000

<210>  291

<400>  291
000

<210>  292

<400>  292
000

<210>  293

<400>  293
000

<210>  294

<400>  294
000

<210>  295

<400>  295
000

<210>  296

<400>  296
000

<210>  297

<400>  297
000

<210>  298

<400>  298
000

<210>  299

<400>  299
000

<210>  300

<400>  300
000

<210>  301

<400>  301
000

<210>  302

<400>  302
000

<210>  303

<400>  303
000

<210>  304

<400>  304
000

<210>  305

<400>  305
000

<210>  306

<400>  306
000

<210>  307

<400>  307
000

<210>  308

<400>  308
000

<210>  309
<211>  2340
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  humanized bispecific construct TRI129

<400>  309
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc      120

tcctgtgcag cctctggatt cacctttagc agctatggca tgagctgggt ccgccaggct      180

ccagggaagg ggctggaggg ggtctcagct attagtggta gtggtggtag cacatactac      240

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      300

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagaaaag      360

ttacgatatt ttgactggtt atccgatgct tttgatatct ggggccaagg gacaatggtc      420

accgtctctt caggtggagg cggttcaggc ggaggtggat ccggcggtgg cggctccggt      480

ggcggcggat ctgacatcgt gatgacccag tctccagact ccctggctgt gtctctgggc      540

gagagggcca ccatcaactg caagtccagc cacagtgttt tatacagctc caacaataag      600

aactacttag cttggtacca gcagaaacca ggacagcctc ctaagctgct catttactgg      660

gcatctaccc gggaatccgg ggtccctgac cgattcagtg gcagcgggtc tgggacagat      720

ttcactctca ccatcagcag cctgcaggct gaagatgtgg cagtttatta ctgtcagcaa      780

tattatagta ctcctccgac cactttcggc ggagggacca aggtggagat caaatcctcg      840

agtgagccca aatcttctga caaaactcac acatgcccac cgtgcccagc acctgaagcc      900

gcgggtgcac cgtcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc      960

cggacccctg aggtcacatg cgtggtggtg gacgtgagcc acgaagaccc tgaggtcaag     1020

ttcaactggt acgtggacgg cgtggaggtg cataatgcca agacaaagcc gcgggaggag     1080

cagtacaaca gcacgtaccg tgtggtcagc gtcctcaccg tcctgcacca ggactggctg     1140

aatggcaagg aatacaagtg cgcggtctcc aacaaagccc tcccagcccc catcgagaaa     1200

accatctcca aagccaaagg gcagccccga gaaccacagg tgtacaccct gcccccatcc     1260

cgggatgagc tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg cttctatcca     1320

agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta caagaccacg     1380

cctcccgtgc tggactccga cggctccttc ttcctctaca gcaagctcac cgtggacaag     1440

agcaggtggc agcaggggaa cgtcttctca tgctccgtga tgcatgaggc tctgcacaac     1500

cactacacgc agaagagcct ctccctgtct ccgggttccg gaggaggggg ttcaggtggg     1560

ggaggttctg gcggcggggg aagcccttca caggtgcaac tggtgcagag tggacccgag     1620

gttaaaaaac cagggtcctc cgttaaggtt agctgcaaag cctctggcta cacattttcc     1680

aggagtacaa tgcactgggt gaggcaggct cctggacagg gactcgagtg gatcgggtat     1740

atcaacccat ctagcgccta taccaattac aaccaaaagt ttaaggaccg agttaccatt     1800

accgctgaca aatccaccag tacagcttat atggagctgt catctcttag gtccgaggac     1860

actgctgttt attactgcgc tcgtcctcag gttcactatg actataatgg ttttccctac     1920

tggggtcagg gaaccctggt gactgtctct tctggcggtg gaggcagcgg tgggggtggg     1980

tctggaggcg gtggcagtgg cggcggaggc tctgatattc agatgactca gtctcctagc     2040

actctcagcg ccagcgtggg ggatcgtgtg acaatgactt gctccgctag cagtagtgtg     2100

tcttacatga attggtatca gcagaagccc gggaaagcac ctaagcgctg gatctatgac     2160

tcttccaagc tggcaagtgg tgtcccctca cggttctctg gctcaggttc tggtactgac     2220

tatactttga ctatctcctc cctccagccc gatgatttcg ctacctatta ttgtcagcag     2280

tggagccgta acccacccac tttcggaggc ggtaccaaag tggagatcaa gaggtcataa     2340


<210>  310
<211>  759
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  humanized bispecific construct TRI129

<400>  310

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Glu Lys Leu Arg Tyr Phe Asp Trp Leu Ser Asp Ala Phe Asp 
            100                 105                 110         


Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
145                 150                 155                 160 


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser His Ser Val Leu Tyr Ser 
                165                 170                 175     


Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
            180                 185                 190         


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
        195                 200                 205             


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
    210                 215                 220                 


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
225                 230                 235                 240 


Tyr Tyr Ser Thr Pro Pro Thr Thr Phe Gly Gly Gly Thr Lys Val Glu 
                245                 250                 255     


Ile Lys Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys 
            260                 265                 270         


Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu 
        275                 280                 285             


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
    290                 295                 300                 


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
305                 310                 315                 320 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
                325                 330                 335     


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
            340                 345                 350         


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala 
        355                 360                 365             


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
    370                 375                 380                 


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
385                 390                 395                 400 


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
                405                 410                 415     


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
            420                 425                 430         


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
        435                 440                 445             


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
    450                 455                 460                 


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
465                 470                 475                 480 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Ser Gly Gly Gly 
                485                 490                 495     


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Pro Ser Gln Val 
            500                 505                 510         


Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ser Ser Val 
        515                 520                 525             


Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Arg Ser Thr Met 
    530                 535                 540                 


His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr 
545                 550                 555                 560 


Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp 
                565                 570                 575     


Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu 
            580                 585                 590         


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
        595                 600                 605             


Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly Gln Gly 
    610                 615                 620                 


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
625                 630                 635                 640 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr 
                645                 650                 655     


Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr Met 
            660                 665                 670         


Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln 
        675                 680                 685             


Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser Lys Leu 
    690                 695                 700                 


Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
705                 710                 715                 720 


Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr 
                725                 730                 735     


Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr 
            740                 745                 750         


Lys Val Glu Ile Lys Arg Ser 
        755                 


<210>  311
<211>  2334
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  humanized bispecific construct TRI130

<400>  311
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc      120

atcaactgca agtccagcca cagtgtttta tacagctcca acaataagaa ctacttagct      180

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      240

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      300

atcagcagcc tgcaggctga agatgtggca gtttattact gtcagcaata ttatagtact      360

cctccgacca ctttcggcgg agggaccaag gtggagatca aaggtggagg cggttcaggc      420

ggaggtggat ccggcggtgg cggctccggt ggcggcggat ctgaggtgca gctgttggag      480

tctgggggag gcttggtaca gcctgggggg tccctgagac tctcctgtgc agcctctgga      540

ttcaccttta gcagctatgg catgagctgg gtccgccagg ctccagggaa ggggctggag      600

ggggtctcag ctattagtgg tagtggtggt agcacatact acgcagactc cgtgaagggc      660

cggttcacca tctccagaga caattccaag aacacgctgt atctgcaaat gaacagcctg      720

agagccgagg acacggccgt atattactgt gcgaaagaaa agttacgata ttttgactgg      780

ttatccgatg cttttgatat ctggggccaa gggacaatgg tcaccgtctc ctcgagtgag      840

cccaaatctt ctgacaaaac tcacacatgc ccaccgtgcc cagcacctga agccgcgggt      900

gcaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc      960

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac     1020

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac     1080

aacagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc     1140

aaggaataca agtgcgcggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc     1200

tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggat     1260

gagctgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tccaagcgac     1320

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc     1380

gtgctggact ccgacggctc cttcttcctc tacagcaagc tcaccgtgga caagagcagg     1440

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac     1500

acgcagaaga gcctctccct gtctccgggt tccggaggag ggggttcagg tgggggaggt     1560

tctggcggcg ggggaagccc ttcacaggtg caactggtgc agagtggacc cgaggttaaa     1620

aaaccagggt cctccgttaa ggttagctgc aaagcctctg gctacacatt ttccaggagt     1680

acaatgcact gggtgaggca ggctcctgga cagggactcg agtggatcgg gtatatcaac     1740

ccatctagcg cctataccaa ttacaaccaa aagtttaagg accgagttac cattaccgct     1800

gacaaatcca ccagtacagc ttatatggag ctgtcatctc ttaggtccga ggacactgct     1860

gtttattact gcgctcgtcc tcaggttcac tatgactata atggttttcc ctactggggt     1920

cagggaaccc tggtgactgt ctcttctggc ggtggaggca gcggtggggg tgggtctgga     1980

ggcggtggca gtggcggcgg aggctctgat attcagatga ctcagtctcc tagcactctc     2040

agcgccagcg tgggggatcg tgtgacaatg acttgctccg ctagcagtag tgtgtcttac     2100

atgaattggt atcagcagaa gcccgggaaa gcacctaagc gctggatcta tgactcttcc     2160

aagctggcaa gtggtgtccc ctcacggttc tctggctcag gttctggtac tgactatact     2220

ttgactatct cctccctcca gcccgatgat ttcgctacct attattgtca gcagtggagc     2280

cgtaacccac ccactttcgg aggcggtacc aaagtggaga tcaagaggtc ataa           2334


<210>  312
<211>  757
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  humanized bispecific construct TRI130

<400>  312

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser His Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Thr Pro Pro Thr Thr Phe Gly Gly Gly Thr Lys Val Glu 
            100                 105                 110         


Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly 
    130                 135                 140                 


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
145                 150                 155                 160 


Phe Thr Phe Ser Ser Tyr Gly Met Ser Trp Val Arg Gln Ala Pro Gly 
                165                 170                 175     


Lys Gly Leu Glu Gly Val Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr 
            180                 185                 190         


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
        195                 200                 205             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    210                 215                 220                 


Thr Ala Val Tyr Tyr Cys Ala Lys Glu Lys Leu Arg Tyr Phe Asp Trp 
225                 230                 235                 240 


Leu Ser Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val 
                245                 250                 255     


Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
            260                 265                 270         


Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro 
        275                 280                 285             


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
    290                 295                 300                 


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
305                 310                 315                 320 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
                325                 330                 335     


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
            340                 345                 350         


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser 
        355                 360                 365             


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
    370                 375                 380                 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
385                 390                 395                 400 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
                405                 410                 415     


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
            420                 425                 430         


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
        435                 440                 445             


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
    450                 455                 460                 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
465                 470                 475                 480 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Ser Gly Gly Gly Gly Ser 
                485                 490                 495     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Pro Ser Gln Val Gln Leu 
            500                 505                 510         


Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val 
        515                 520                 525             


Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Arg Ser Thr Met His Trp 
    530                 535                 540                 


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn 
545                 550                 555                 560 


Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Val 
                565                 570                 575     


Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser 
            580                 585                 590         


Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Pro Gln 
        595                 600                 605             


Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly Gln Gly Thr Leu 
    610                 615                 620                 


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
625                 630                 635                 640 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
                645                 650                 655     


Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr Met Thr Cys 
            660                 665                 670         


Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro 
        675                 680                 685             


Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser Lys Leu Ala Ser 
    690                 695                 700                 


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 
705                 710                 715                 720 


Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys 
                725                 730                 735     


Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Val 
            740                 745                 750         


Glu Ile Lys Arg Ser 
        755         


<210>  313

<400>  313
000

<210>  314

<400>  314
000

<210>  315

<400>  315
000

<210>  316

<400>  316
000

<210>  317

<400>  317
000

<210>  318

<400>  318
000

<210>  319

<400>  319
000

<210>  320

<400>  320
000

<210>  321

<400>  321
000

<210>  322

<400>  322
000

<210>  323

<400>  323
000

<210>  324

<400>  324
000

<210>  325

<400>  325
000

<210>  326

<400>  326
000

<210>  327

<400>  327
000

<210>  328

<400>  328
000

<210>  329

<400>  329
000

<210>  330

<400>  330
000

<210>  331

<400>  331
000

<210>  332

<400>  332
000

<210>  333

<400>  333
000

<210>  334

<400>  334
000

<210>  335

<400>  335
000

<210>  336

<400>  336
000

<210>  337
<211>  777
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  humanized bispecific construct TRI130

<400>  337

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala 
            20                  25                  30          


Val Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser His Ser 
        35                  40                  45              


Val Leu Tyr Ser Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg 
65                  70                  75                  80  


Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr 
            100                 105                 110         


Tyr Cys Gln Gln Tyr Tyr Ser Thr Pro Pro Thr Thr Phe Gly Gly Gly 
        115                 120                 125             


Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu 
145                 150                 155                 160 


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
                165                 170                 175     


Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Gly Met Ser Trp Val Arg 
            180                 185                 190         


Gln Ala Pro Gly Lys Gly Leu Glu Gly Val Ser Ala Ile Ser Gly Ser 
        195                 200                 205             


Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Glu Lys Leu Arg 
                245                 250                 255     


Tyr Phe Asp Trp Leu Ser Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr 
            260                 265                 270         


Met Val Thr Val Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
        275                 280                 285             


Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val 
    290                 295                 300                 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
305                 310                 315                 320 


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
                325                 330                 335     


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
            340                 345                 350         


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
        355                 360                 365             


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
    370                 375                 380                 


Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
385                 390                 395                 400 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
                405                 410                 415     


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
            420                 425                 430         


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
        435                 440                 445             


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
    450                 455                 460                 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
465                 470                 475                 480 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
                485                 490                 495     


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Ser Gly 
            500                 505                 510         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Pro Ser 
        515                 520                 525             


Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ser 
    530                 535                 540                 


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Arg Ser 
545                 550                 555                 560 


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
                565                 570                 575     


Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe 
            580                 585                 590         


Lys Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
        595                 600                 605             


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
    610                 615                 620                 


Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly 
625                 630                 635                 640 


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                645                 650                 655     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln 
            660                 665                 670         


Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val 
        675                 680                 685             


Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr 
    690                 695                 700                 


Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser 
705                 710                 715                 720 


Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
                725                 730                 735     


Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala 
            740                 745                 750         


Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly 
        755                 760                 765             


Gly Thr Lys Val Glu Ile Lys Arg Ser 
    770                 775         


<210>  338

<400>  338
000

<210>  339

<400>  339
000

<210>  340

<400>  340
000

<210>  341
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cris-7 variable light chain sequence

<400>  341

Gln Val Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Phe Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Ser Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Thr Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Gln Ile Thr Arg 
            100                 105         


<210>  342
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cris-7 variable heavy chain sequence

<400>  342

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120     


<210>  343
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HuM291 variable light chain sequence

<400>  343

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  344
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HuM291 variable heavy chain sequence

<400>  344

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Ser Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Arg Ser Gly Tyr Thr His Tyr Asn Gln Lys Leu 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Ala Tyr Tyr Asp Tyr Asp Gly Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  345
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cris7 and DRA222 VH CDR1 (Kabat)

<400>  345

Arg Ser Thr Met His 
1               5   


<210>  346
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cris7 and DRA222 VH CDR2 (Kabat)

<400>  346

Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


<210>  347
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cris7 and DRA222 VH CDR3 (Kabat)

<400>  347

Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr 
1               5                   10      


<210>  348
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cris7 and DRA222 VL CDR1 (Kabat)

<400>  348

Ser Ala Ser Ser Ser Val Ser Tyr Met Asn 
1               5                   10  


<210>  349
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cris7 and DRA222 VL CDR2 (Kabat)

<400>  349

Asp Ser Ser Lys Leu Ala Ser 
1               5           


<210>  350
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cris7 and DRA222 VL CDR3 (Kabat)

<400>  350

Gln Gln Trp Ser Arg Asn Pro Pro Thr 
1               5                   


<210>  351
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cris7 and DRA222 VH CDR1 (IMGT)

<400>  351

Gly Tyr Thr Phe Thr Arg Ser Thr 
1               5               


<210>  352
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cris7 and DRA222 VH CDR2 (IMGT)

<400>  352

Ile Asn Pro Ser Ser Ala Tyr Thr 
1               5               


<210>  353
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cris7 and DRA222 VH CDR3 (IMGT)

<400>  353

Gln Gln Trp Ser Arg Asn Pro Pro Thr 
1               5                   


<210>  354
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cris7 and DRA222 VL CDR1 (IMGT)

<400>  354

Ala Ser Ser Ser Val Ser Tyr 
1               5           


<210>  355
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cris7 and DRA222 VL CDR2 (IMGT)

<400>  355

Asp Ser Ser 
1           


<210>  356
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cris7 and DRA222 VL CDR3 (IMGT)

<400>  356

Gln Gln Trp Ser Arg Asn Pro Pro Thr 
1               5                   


<210>  357
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  I2C VH CDR1 (Kabat)

<400>  357

Lys Tyr Ala Met Asn 
1               5   


<210>  358
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  I2C VH CDR2 (Kabat)

<400>  358

Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210>  359
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  I2C VH CDR3 (Kabat)

<400>  359

His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr 
1               5                   10                  


<210>  360
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  I2C VL CDR1 (Kabat)

<400>  360

Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn 
1               5                   10                  


<210>  361
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  I2C VL CDR2 (Kabat)

<400>  361

Gly Thr Lys Phe Leu Ala Pro 
1               5           


<210>  362
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  I2C VL CDR3 (Kabat)

<400>  362

Val Leu Trp Tyr Ser Asn Arg Trp Val 
1               5                   


<210>  363
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  I2C VH CDR1 (IMGT)

<400>  363

Gly Phe Thr Phe Asn Lys Tyr Ala 
1               5               


<210>  364
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  I2C VH CDR2 (IMGT)

<400>  364

Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr 
1               5                   10  


<210>  365
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  I2C VH CDR3 (IMGT)

<400>  365

Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr 
1               5                   10                  15      


<210>  366
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  I2C VL CDR1 (IMGT)

<400>  366

Thr Gly Ala Val Thr Ser Gly Asn Tyr 
1               5                   


<210>  367
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  I2C VL CDR2 (IMGT)

<400>  367

Gly Thr Lys 
1           


<210>  368
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  I2C VL CDR3 (IMGT)

<400>  368

Val Leu Trp Tyr Ser Asn Arg Trp Val 
1               5                   


<210>  369
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HuM291 VH CDR1 (Kabat)

<400>  369

Ser Tyr Thr Met His 
1               5   


<210>  370
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HuM291 VH CDR2 (Kabat)

<400>  370

Tyr Ile Asn Pro Arg Ser Gly Tyr Thr His Tyr Asn Gln Lys Leu Lys 
1               5                   10                  15      


Asp 
    


<210>  371
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HuM291 VH CDR3 (Kabat)

<400>  371

Ser Ala Tyr Tyr Asp Tyr Asp Gly Phe Ala Tyr 
1               5                   10      


<210>  372
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HuM291 VL CDR1 (Kabat)

<400>  372

Ser Ala Ser Ser Ser Val Ser Tyr Met Asn 
1               5                   10  


<210>  373
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HuM291 VL CDR2 (Kabat)

<400>  373

Asp Thr Ser Lys Leu Ala Ser 
1               5           


<210>  374
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HuM291 VL CDR3 (Kabat)

<400>  374

Gln Gln Trp Ser Ser Asn Pro Pro Thr 
1               5                   


<210>  375
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HuM291 VH CDR1 (IMGT)

<400>  375

Gly Tyr Thr Phe Ile Ser Tyr Thr 
1               5               


<210>  376
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HuM291 VH CDR2 (IMGT)

<400>  376

Ile Asn Pro Arg Ser Gly Tyr Thr 
1               5               


<210>  377
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HuM291 VH CDR3 (IMGT)

<400>  377

Ala Arg Ser Ala Tyr Tyr Asp Tyr Asp Gly Phe Ala Tyr 
1               5                   10              


<210>  378
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HuM291 VL CDR1 (IMGT)

<400>  378

Ala Ser Ser Ser Val Ser Tyr 
1               5           


<210>  379
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HuM291 VL CDR2 (IMGT)

<400>  379

Asp Thr Ser 
1           


<210>  380
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HuM291 VL CDR3 (IMGT)

<400>  380

Gln Gln Trp Ser Ser Asn Pro Pro Thr 
1               5                   


<210>  381
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TSC455 (anti-CD3) TSC394 F87Y scFv

<400>  381

Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Arg Ser 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln 
    130                 135                 140                 


Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val 
145                 150                 155                 160 


Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser 
            180                 185                 190         


Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Glu Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys Arg Ser Ser Ser 
                245                 250     


<210>  382
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TSC456 (anti-CD3) TSC394 E86D F87Y scFv

<400>  382

Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Arg Ser 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln 
    130                 135                 140                 


Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val 
145                 150                 155                 160 


Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser 
            180                 185                 190         


Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys Arg Ser Ser Ser 
                245                 250     


<210>  383
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TSC455 and TSC456 variable heavy domain

<400>  383

Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Arg Ser 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  384
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TSC455 variable light domain

<400>  384

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Ser Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Ser 
            100                 105             


<210>  385
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TSC456 variable light domain

<400>  385

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Ser Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Ser 
            100                 105             


<210>  386
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DRA222 (anti-CD3)  scFv

<400>  386

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Ala Asp Lys Ser Lys Ser Thr Ala Phe 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Pro Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Ala Gln Asp Ile Gln Met Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Met Thr 
145                 150                 155                 160 


Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser Lys Leu Ala 
            180                 185                 190         


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Leu Gln Ile Thr Ser Ser Ser 
                245         


<210>  387
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DRA222 variable heavy domain

<400>  387

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Ala Asp Lys Ser Lys Ser Thr Ala Phe 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Pro Val Thr Val Ser Ser 
        115                 120     


<210>  388
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DRA222 variable light domain

<400>  388

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Ser Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Gln Ile Thr Ser 
            100                 105         


<210>  389

<400>  389
000

<210>  390
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  hinge region


<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Xaa can be any naturally occurring amino acid

<400>  390

Cys Xaa Xaa Cys 
1               


