﻿                         序列表

<110>  中国科学院动物研究所
       北京干细胞与再生医学研究院

<120>  工程化的Cas12i核酸酶、效应蛋白及其用途

<130>  FF00614PCT

<141>  2022-05-25

<150>  PCT/CN2021/096477
<151>  2021-05-27

<150>  CN2021105812903
<151>  2021-05-27

<150>  CN2021113479527
<151>  2021-11-15

<160>  79

<170>  SIPOSequenceListing 1.0

<210>  1
<211>  1054
<212>  PRT
<213>  Artificial Sequence

<400>  1
Met Ser Ser Ala Ile Lys Ser Tyr Lys Ser Val Leu Arg Pro Asn Glu 
1               5                   10                  15      
Arg Lys Asn Gln Leu Leu Lys Ser Thr Ile Gln Cys Leu Glu Asp Gly 
            20                  25                  30          
Ser Ala Phe Phe Phe Lys Met Leu Gln Gly Leu Phe Gly Gly Ile Thr 
        35                  40                  45              
Pro Glu Ile Val Arg Phe Ser Thr Glu Gln Glu Lys Gln Gln Gln Asp 
    50                  55                  60                  
Ile Ala Leu Trp Cys Ala Val Asn Trp Phe Arg Pro Val Ser Gln Asp 
65                  70                  75                  80  
Ser Leu Thr His Thr Ile Ala Ser Asp Asn Leu Val Glu Lys Phe Glu 
                85                  90                  95      
Glu Tyr Tyr Gly Gly Thr Ala Ser Asp Ala Ile Lys Gln Tyr Phe Ser 
            100                 105                 110         
Ala Ser Ile Gly Glu Ser Tyr Tyr Trp Asn Asp Cys Arg Gln Gln Tyr 
        115                 120                 125             
Tyr Asp Leu Cys Arg Glu Leu Gly Val Glu Val Ser Asp Leu Thr His 
    130                 135                 140                 
Asp Leu Glu Ile Leu Cys Arg Glu Lys Cys Leu Ala Val Ala Thr Glu 
145                 150                 155                 160 
Ser Asn Gln Asn Asn Ser Ile Ile Ser Val Leu Phe Gly Thr Gly Glu 
                165                 170                 175     
Lys Glu Asp Arg Ser Val Lys Leu Arg Ile Thr Lys Lys Ile Leu Glu 
            180                 185                 190         
Ala Ile Ser Asn Leu Lys Glu Ile Pro Lys Asn Val Ala Pro Ile Gln 
        195                 200                 205             
Glu Ile Ile Leu Asn Val Ala Lys Ala Thr Lys Glu Thr Phe Arg Gln 
    210                 215                 220                 
Val Tyr Ala Gly Asn Leu Gly Ala Pro Ser Thr Leu Glu Lys Phe Ile 
225                 230                 235                 240 
Ala Lys Asp Gly Gln Lys Glu Phe Asp Leu Lys Lys Leu Gln Thr Asp 
                245                 250                 255     
Leu Lys Lys Val Ile Arg Gly Lys Ser Lys Glu Arg Asp Trp Cys Cys 
            260                 265                 270         
Gln Glu Glu Leu Arg Ser Tyr Val Glu Gln Asn Thr Ile Gln Tyr Asp 
        275                 280                 285             
Leu Trp Ala Trp Gly Glu Met Phe Asn Lys Ala His Thr Ala Leu Lys 
    290                 295                 300                 
Ile Lys Ser Thr Arg Asn Tyr Asn Phe Ala Lys Gln Arg Leu Glu Gln 
305                 310                 315                 320 
Phe Lys Glu Ile Gln Ser Leu Asn Asn Leu Leu Val Val Lys Lys Leu 
                325                 330                 335     
Asn Asp Phe Phe Asp Ser Glu Phe Phe Ser Gly Glu Glu Thr Tyr Thr 
            340                 345                 350         
Ile Cys Val His His Leu Gly Gly Lys Asp Leu Ser Lys Leu Tyr Lys 
        355                 360                 365             
Ala Trp Glu Asp Asp Pro Ala Asp Pro Glu Asn Ala Ile Val Val Leu 
    370                 375                 380                 
Cys Asp Asp Leu Lys Asn Asn Phe Lys Lys Glu Pro Ile Arg Asn Ile 
385                 390                 395                 400 
Leu Arg Tyr Ile Phe Thr Ile Arg Gln Glu Cys Ser Ala Gln Asp Ile 
                405                 410                 415     
Leu Ala Ala Ala Lys Tyr Asn Gln Gln Leu Asp Arg Tyr Lys Ser Gln 
            420                 425                 430         
Lys Ala Asn Pro Ser Val Leu Gly Asn Gln Gly Phe Thr Trp Thr Asn 
        435                 440                 445             
Ala Val Ile Leu Pro Glu Lys Ala Gln Arg Asn Asp Arg Pro Asn Ser 
    450                 455                 460                 
Leu Asp Leu Arg Ile Trp Leu Tyr Leu Lys Leu Arg His Pro Asp Gly 
465                 470                 475                 480 
Arg Trp Lys Lys His His Ile Pro Phe Tyr Asp Thr Arg Phe Phe Gln 
                485                 490                 495     
Glu Ile Tyr Ala Ala Gly Asn Ser Pro Val Asp Thr Cys Gln Phe Arg 
            500                 505                 510         
Thr Pro Arg Phe Gly Tyr His Leu Pro Lys Leu Thr Asp Gln Thr Ala 
        515                 520                 525             
Ile Arg Val Asn Lys Lys His Val Lys Ala Ala Lys Thr Glu Ala Arg 
    530                 535                 540                 
Ile Arg Leu Ala Ile Gln Gln Gly Thr Leu Pro Val Ser Asn Leu Lys 
545                 550                 555                 560 
Ile Thr Glu Ile Ser Ala Thr Ile Asn Ser Lys Gly Gln Val Arg Ile 
                565                 570                 575     
Pro Val Lys Phe Asp Val Gly Arg Gln Lys Gly Thr Leu Gln Ile Gly 
            580                 585                 590         
Asp Arg Phe Cys Gly Tyr Asp Gln Asn Gln Thr Ala Ser His Ala Tyr 
        595                 600                 605             
Ser Leu Trp Glu Val Val Lys Glu Gly Gln Tyr His Lys Glu Leu Gly 
    610                 615                 620                 
Cys Phe Val Arg Phe Ile Ser Ser Gly Asp Ile Val Ser Ile Thr Glu 
625                 630                 635                 640 
Asn Arg Gly Asn Gln Phe Asp Gln Leu Ser Tyr Glu Gly Leu Ala Tyr 
                645                 650                 655     
Pro Gln Tyr Ala Asp Trp Arg Lys Lys Ala Ser Lys Phe Val Ser Leu 
            660                 665                 670         
Trp Gln Ile Thr Lys Lys Asn Lys Lys Lys Glu Ile Val Thr Val Glu 
        675                 680                 685             
Ala Lys Glu Lys Phe Asp Ala Ile Cys Lys Tyr Gln Pro Arg Leu Tyr 
    690                 695                 700                 
Lys Phe Asn Lys Glu Tyr Ala Tyr Leu Leu Arg Asp Ile Val Arg Gly 
705                 710                 715                 720 
Lys Ser Leu Val Glu Leu Gln Gln Ile Arg Gln Glu Ile Phe Arg Phe 
                725                 730                 735     
Ile Glu Gln Asp Cys Gly Val Thr Arg Leu Gly Ser Leu Ser Leu Ser 
            740                 745                 750         
Thr Leu Glu Thr Val Lys Ala Val Lys Gly Ile Ile Tyr Ser Tyr Phe 
        755                 760                 765             
Ser Thr Ala Leu Asn Ala Ser Lys Asn Asn Pro Ile Ser Asp Glu Gln 
    770                 775                 780                 
Arg Lys Glu Phe Asp Pro Glu Leu Phe Ala Leu Leu Glu Lys Leu Glu 
785                 790                 795                 800 
Leu Ile Arg Thr Arg Lys Lys Lys Gln Lys Val Glu Arg Ile Ala Asn 
                805                 810                 815     
Ser Leu Ile Gln Thr Cys Leu Glu Asn Asn Ile Lys Phe Ile Arg Gly 
            820                 825                 830         
Glu Gly Asp Leu Ser Thr Thr Asn Asn Ala Thr Lys Lys Lys Ala Asn 
        835                 840                 845             
Ser Arg Ser Met Asp Trp Leu Ala Arg Gly Val Phe Asn Lys Ile Arg 
    850                 855                 860                 
Gln Leu Ala Pro Met His Asn Ile Thr Leu Phe Gly Cys Gly Ser Leu 
865                 870                 875                 880 
Tyr Thr Ser His Gln Asp Pro Leu Val His Arg Asn Pro Asp Lys Ala 
                885                 890                 895     
Met Lys Cys Arg Trp Ala Ala Ile Pro Val Lys Asp Ile Gly Asp Trp 
            900                 905                 910         
Val Leu Arg Lys Leu Ser Gln Asn Leu Arg Ala Lys Asn Ile Gly Thr 
        915                 920                 925             
Gly Glu Tyr Tyr His Gln Gly Val Lys Glu Phe Leu Ser His Tyr Glu 
    930                 935                 940                 
Leu Gln Asp Leu Glu Glu Glu Leu Leu Lys Trp Arg Ser Asp Arg Lys 
945                 950                 955                 960 
Ser Asn Ile Pro Cys Trp Val Leu Gln Asn Arg Leu Ala Glu Lys Leu 
                965                 970                 975     
Gly Asn Lys Glu Ala Val Val Tyr Ile Pro Val Arg Gly Gly Arg Ile 
            980                 985                 990         
Tyr Phe Ala Thr His Lys Val Ala  Thr Gly Ala Val Ser  Ile Val Phe 
        995                 1000                 1005             
Asp Gln  Lys Gln Val Trp Val  Cys Asn Ala Asp His  Val Ala Ala Ala 
    1010                 1015                 1020                 
Asn  Ile Ala Leu Thr Val  Lys Gly Ile Gly Glu  Gln Ser Ser Asp Glu  
1025                 1030                 1035                 1040 
Glu Asn Pro Asp Gly  Ser Arg Ile Lys Leu  Gln Leu Thr Ser 
                1045                 1050                 

<210>  2
<211>  1054
<212>  PRT
<213>  Artificial Sequence

<400>  2
Met Ser Ser Ala Ile Lys Ser Tyr Lys Ser Val Leu Arg Pro Asn Glu 
1               5                   10                  15      
Arg Lys Asn Gln Leu Leu Lys Ser Thr Ile Gln Cys Leu Glu Asp Gly 
            20                  25                  30          
Ser Ala Phe Phe Phe Lys Met Leu Gln Gly Leu Phe Gly Gly Ile Thr 
        35                  40                  45              
Pro Glu Ile Val Arg Phe Ser Thr Glu Gln Glu Lys Gln Gln Gln Asp 
    50                  55                  60                  
Ile Ala Leu Trp Cys Ala Val Asn Trp Phe Arg Pro Val Ser Gln Asp 
65                  70                  75                  80  
Ser Leu Thr His Thr Ile Ala Ser Asp Asn Leu Val Glu Lys Phe Glu 
                85                  90                  95      
Glu Tyr Tyr Gly Gly Thr Ala Ser Asp Ala Ile Lys Gln Tyr Phe Ser 
            100                 105                 110         
Ala Ser Ile Gly Glu Ser Tyr Tyr Trp Asn Asp Cys Arg Gln Gln Tyr 
        115                 120                 125             
Tyr Asp Leu Cys Arg Glu Leu Gly Val Glu Val Ser Asp Leu Thr His 
    130                 135                 140                 
Asp Leu Glu Ile Leu Cys Arg Glu Lys Cys Leu Ala Val Ala Thr Glu 
145                 150                 155                 160 
Ser Asn Gln Tyr Asn Ser Ile Ile Ser Val Leu Phe Gly Thr Gly Arg 
                165                 170                 175     
Lys Glu Asp Arg Ser Val Lys Leu Arg Ile Thr Lys Lys Ile Leu Glu 
            180                 185                 190         
Ala Ile Ser Asn Leu Lys Glu Ile Pro Lys Asn Val Ala Pro Ile Gln 
        195                 200                 205             
Glu Ile Ile Leu Asn Val Ala Lys Ala Thr Lys Glu Thr Phe Arg Gln 
    210                 215                 220                 
Val Tyr Ala Gly Asn Leu Gly Ala Pro Ser Thr Leu Glu Arg Phe Ile 
225                 230                 235                 240 
Ala Lys Asp Gly Gln Lys Glu Phe Asp Leu Lys Lys Leu Gln Thr Asp 
                245                 250                 255     
Leu Lys Lys Val Ile Arg Gly Lys Ser Lys Glu Arg Asp Trp Cys Cys 
            260                 265                 270         
Gln Glu Glu Leu Arg Ser Tyr Val Glu Gln Asn Thr Ile Gln Tyr Asp 
        275                 280                 285             
Leu Trp Ala Trp Gly Glu Met Phe Asn Lys Ala His Thr Ala Leu Lys 
    290                 295                 300                 
Ile Lys Ser Thr Arg Asn Tyr Asn Phe Ala Lys Gln Arg Leu Glu Gln 
305                 310                 315                 320 
Phe Lys Glu Ile Gln Ser Leu Asn Asn Leu Leu Val Val Lys Lys Leu 
                325                 330                 335     
Asn Asp Phe Phe Asp Ser Glu Phe Phe Ser Gly Glu Glu Thr Tyr Thr 
            340                 345                 350         
Ile Cys Val His His Leu Gly Gly Lys Asp Leu Ser Lys Leu Tyr Lys 
        355                 360                 365             
Ala Trp Glu Asp Asp Pro Ala Asp Pro Glu Asn Ala Ile Val Val Leu 
    370                 375                 380                 
Cys Asp Asp Leu Lys Asn Asn Phe Lys Lys Glu Pro Ile Arg Asn Ile 
385                 390                 395                 400 
Leu Arg Tyr Ile Phe Thr Ile Arg Gln Glu Cys Ser Ala Gln Asp Ile 
                405                 410                 415     
Leu Ala Ala Ala Lys Tyr Asn Gln Gln Leu Asp Arg Tyr Lys Ser Gln 
            420                 425                 430         
Lys Ala Asn Pro Ser Val Leu Gly Asn Gln Gly Phe Thr Trp Arg Asn 
        435                 440                 445             
Ala Val Ile Leu Pro Glu Lys Ala Gln Arg Asn Asp Arg Pro Asn Ser 
    450                 455                 460                 
Leu Asp Leu Arg Ile Trp Leu Tyr Leu Lys Leu Arg His Pro Asp Gly 
465                 470                 475                 480 
Arg Trp Lys Lys His His Ile Pro Phe Tyr Asp Thr Arg Phe Phe Gln 
                485                 490                 495     
Glu Ile Tyr Ala Ala Gly Asn Ser Pro Val Asp Thr Cys Gln Phe Arg 
            500                 505                 510         
Thr Pro Arg Phe Gly Tyr His Leu Pro Lys Leu Thr Asp Gln Thr Ala 
        515                 520                 525             
Ile Arg Val Asn Lys Lys His Val Lys Ala Ala Lys Thr Glu Ala Arg 
    530                 535                 540                 
Ile Arg Leu Ala Ile Gln Gln Gly Thr Leu Pro Val Ser Asn Leu Lys 
545                 550                 555                 560 
Ile Thr Arg Ile Ser Ala Thr Ile Asn Ser Lys Gly Gln Val Arg Ile 
                565                 570                 575     
Pro Val Lys Phe Asp Val Gly Arg Gln Lys Gly Thr Leu Gln Ile Gly 
            580                 585                 590         
Asp Arg Phe Cys Gly Tyr Asp Gln Asn Gln Thr Ala Ser His Ala Tyr 
        595                 600                 605             
Ser Leu Trp Glu Val Val Lys Glu Gly Gln Tyr His Lys Glu Leu Gly 
    610                 615                 620                 
Cys Phe Val Arg Phe Ile Ser Ser Gly Asp Ile Val Ser Ile Thr Glu 
625                 630                 635                 640 
Asn Arg Gly Asn Gln Phe Asp Gln Leu Ser Tyr Glu Gly Leu Ala Tyr 
                645                 650                 655     
Pro Gln Tyr Ala Asp Trp Arg Lys Lys Ala Ser Lys Phe Val Ser Leu 
            660                 665                 670         
Trp Gln Ile Thr Lys Lys Asn Lys Lys Lys Glu Ile Val Thr Val Glu 
        675                 680                 685             
Ala Lys Glu Lys Phe Asp Ala Ile Cys Lys Tyr Gln Pro Arg Leu Tyr 
    690                 695                 700                 
Lys Phe Asn Lys Glu Tyr Ala Tyr Leu Leu Arg Asp Ile Val Arg Gly 
705                 710                 715                 720 
Lys Ser Leu Val Glu Leu Gln Gln Ile Arg Gln Glu Ile Phe Arg Phe 
                725                 730                 735     
Ile Glu Gln Asp Cys Gly Val Thr Arg Leu Gly Ser Leu Ser Leu Ser 
            740                 745                 750         
Thr Leu Glu Thr Val Lys Ala Val Lys Gly Ile Ile Tyr Ser Tyr Phe 
        755                 760                 765             
Ser Thr Ala Leu Asn Ala Ser Lys Asn Asn Pro Ile Ser Asp Glu Gln 
    770                 775                 780                 
Arg Lys Glu Phe Asp Pro Glu Leu Phe Ala Leu Leu Glu Lys Leu Glu 
785                 790                 795                 800 
Leu Ile Arg Thr Arg Lys Lys Lys Gln Lys Val Glu Arg Ile Ala Asn 
                805                 810                 815     
Ser Leu Ile Gln Thr Cys Leu Glu Asn Asn Ile Lys Phe Ile Arg Gly 
            820                 825                 830         
Glu Gly Asp Leu Ser Thr Thr Asn Asn Ala Thr Lys Lys Lys Ala Asn 
        835                 840                 845             
Ser Arg Ser Met Asp Trp Leu Ala Arg Gly Val Phe Asn Lys Ile Arg 
    850                 855                 860                 
Gln Leu Ala Pro Met His Asn Ile Thr Leu Phe Gly Cys Gly Ser Leu 
865                 870                 875                 880 
Tyr Thr Ser His Gln Asp Pro Leu Val His Arg Asn Pro Asp Lys Ala 
                885                 890                 895     
Met Lys Cys Arg Trp Ala Ala Ile Pro Val Lys Asp Ile Gly Asp Trp 
            900                 905                 910         
Val Leu Arg Lys Leu Ser Gln Asn Leu Arg Ala Lys Asn Ile Gly Thr 
        915                 920                 925             
Gly Glu Tyr Tyr His Gln Gly Val Lys Glu Phe Leu Ser His Tyr Glu 
    930                 935                 940                 
Leu Gln Asp Leu Glu Glu Glu Leu Leu Lys Trp Arg Ser Asp Arg Lys 
945                 950                 955                 960 
Ser Asn Ile Pro Cys Trp Val Leu Gln Asn Arg Leu Ala Glu Lys Leu 
                965                 970                 975     
Gly Asn Lys Glu Ala Val Val Tyr Ile Pro Val Arg Gly Gly Arg Ile 
            980                 985                 990         
Tyr Phe Ala Thr His Lys Val Ala  Thr Gly Ala Val Ser  Ile Val Phe 
        995                 1000                 1005             
Asp Gln  Lys Gln Val Trp Val  Cys Asn Ala Asp His  Val Ala Ala Ala 
    1010                 1015                 1020                 
Asn  Ile Ala Leu Thr Val  Lys Gly Ile Gly Glu  Gln Ser Ser Asp Glu  
1025                 1030                 1035                 1040 
Glu Asn Pro Asp Gly  Ser Arg Ile Lys Leu  Gln Leu Thr Ser 
                1045                 1050                 

<210>  3
<211>  1054
<212>  PRT
<213>  Artificial Sequence

<400>  3
Met Ser Ser Ala Ile Lys Ser Tyr Lys Ser Val Leu Arg Pro Asn Glu 
1               5                   10                  15      
Arg Lys Asn Gln Leu Leu Lys Ser Thr Ile Gln Cys Leu Glu Asp Gly 
            20                  25                  30          
Ser Ala Phe Phe Phe Lys Met Leu Gln Gly Leu Phe Gly Gly Ile Thr 
        35                  40                  45              
Pro Glu Ile Val Arg Phe Ser Thr Glu Gln Glu Lys Gln Gln Gln Asp 
    50                  55                  60                  
Ile Ala Leu Trp Cys Ala Val Asn Trp Phe Arg Pro Val Ser Gln Asp 
65                  70                  75                  80  
Ser Leu Thr His Thr Ile Ala Ser Asp Asn Leu Val Glu Lys Phe Glu 
                85                  90                  95      
Glu Tyr Tyr Gly Gly Thr Ala Ser Asp Ala Ile Lys Gln Tyr Phe Ser 
            100                 105                 110         
Ala Ser Ile Gly Glu Ser Tyr Tyr Trp Asn Asp Cys Arg Gln Gln Tyr 
        115                 120                 125             
Tyr Asp Leu Cys Arg Glu Leu Gly Val Glu Val Ser Asp Leu Thr His 
    130                 135                 140                 
Asp Leu Glu Ile Leu Cys Arg Glu Lys Cys Leu Ala Val Ala Thr Glu 
145                 150                 155                 160 
Ser Asn Gln Asn Asn Ser Ile Ile Ser Val Leu Phe Gly Thr Gly Arg 
                165                 170                 175     
Lys Glu Asp Arg Ser Val Lys Leu Arg Ile Thr Lys Lys Ile Leu Glu 
            180                 185                 190         
Ala Ile Ser Asn Leu Lys Glu Ile Pro Lys Asn Val Ala Pro Ile Gln 
        195                 200                 205             
Glu Ile Ile Leu Asn Val Ala Lys Ala Thr Lys Glu Thr Phe Arg Gln 
    210                 215                 220                 
Val Tyr Ala Gly Asn Leu Gly Ala Pro Ser Thr Leu Glu Arg Phe Ile 
225                 230                 235                 240 
Ala Lys Asp Gly Gln Lys Glu Phe Asp Leu Lys Lys Leu Gln Thr Asp 
                245                 250                 255     
Leu Lys Lys Val Ile Arg Gly Lys Ser Lys Glu Arg Asp Trp Cys Cys 
            260                 265                 270         
Gln Glu Glu Leu Arg Ser Tyr Val Glu Gln Asn Thr Ile Gln Tyr Asp 
        275                 280                 285             
Leu Trp Ala Trp Gly Glu Met Phe Asn Lys Ala His Thr Ala Leu Lys 
    290                 295                 300                 
Ile Lys Ser Thr Arg Asn Tyr Asn Phe Ala Lys Gln Arg Leu Glu Gln 
305                 310                 315                 320 
Phe Lys Glu Ile Gln Ser Leu Asn Asn Leu Leu Val Val Lys Lys Leu 
                325                 330                 335     
Asn Asp Phe Phe Asp Ser Glu Phe Phe Ser Gly Glu Glu Thr Tyr Thr 
            340                 345                 350         
Ile Cys Val His His Leu Gly Gly Lys Asp Leu Ser Lys Leu Tyr Lys 
        355                 360                 365             
Ala Trp Glu Asp Asp Pro Ala Asp Pro Glu Asn Ala Ile Val Val Leu 
    370                 375                 380                 
Cys Asp Asp Leu Lys Asn Asn Phe Lys Lys Glu Pro Ile Arg Asn Ile 
385                 390                 395                 400 
Leu Arg Tyr Ile Phe Thr Ile Arg Gln Glu Cys Ser Ala Gln Asp Ile 
                405                 410                 415     
Leu Ala Ala Ala Lys Tyr Asn Gln Gln Leu Asp Arg Tyr Lys Ser Gln 
            420                 425                 430         
Lys Ala Asn Pro Ser Val Leu Gly Asn Gln Gly Phe Thr Trp Arg Asn 
        435                 440                 445             
Ala Val Ile Leu Pro Glu Lys Ala Gln Arg Asn Asp Arg Pro Asn Ser 
    450                 455                 460                 
Leu Asp Leu Arg Ile Trp Leu Tyr Leu Lys Leu Arg His Pro Asp Gly 
465                 470                 475                 480 
Arg Trp Lys Lys His His Ile Pro Phe Tyr Asp Thr Arg Phe Phe Gln 
                485                 490                 495     
Glu Ile Tyr Ala Ala Gly Asn Ser Pro Val Asp Thr Cys Gln Phe Arg 
            500                 505                 510         
Thr Pro Arg Phe Gly Tyr His Leu Pro Lys Leu Thr Asp Gln Thr Ala 
        515                 520                 525             
Ile Arg Val Asn Lys Lys His Val Lys Ala Ala Lys Thr Glu Ala Arg 
    530                 535                 540                 
Ile Arg Leu Ala Ile Gln Gln Gly Thr Leu Pro Val Ser Asn Leu Lys 
545                 550                 555                 560 
Ile Thr Arg Ile Ser Ala Thr Ile Asn Ser Lys Gly Gln Val Arg Ile 
                565                 570                 575     
Pro Val Lys Phe Asp Val Gly Arg Gln Lys Gly Thr Leu Gln Ile Gly 
            580                 585                 590         
Asp Arg Phe Cys Gly Tyr Asp Gln Asn Gln Thr Ala Ser His Ala Tyr 
        595                 600                 605             
Ser Leu Trp Glu Val Val Lys Glu Gly Gln Tyr His Lys Glu Leu Gly 
    610                 615                 620                 
Cys Phe Val Arg Phe Ile Ser Ser Gly Asp Ile Val Ser Ile Thr Glu 
625                 630                 635                 640 
Asn Arg Gly Asn Gln Phe Asp Gln Leu Ser Tyr Glu Gly Leu Ala Tyr 
                645                 650                 655     
Pro Gln Tyr Ala Asp Trp Arg Lys Lys Ala Ser Lys Phe Val Ser Leu 
            660                 665                 670         
Trp Gln Ile Thr Lys Lys Asn Lys Lys Lys Glu Ile Val Thr Val Glu 
        675                 680                 685             
Ala Lys Glu Lys Phe Asp Ala Ile Cys Lys Tyr Gln Pro Arg Leu Tyr 
    690                 695                 700                 
Lys Phe Asn Lys Glu Tyr Ala Tyr Leu Leu Arg Asp Ile Val Arg Gly 
705                 710                 715                 720 
Lys Ser Leu Val Glu Leu Gln Gln Ile Arg Gln Glu Ile Phe Arg Phe 
                725                 730                 735     
Ile Glu Gln Asp Cys Gly Val Thr Arg Leu Gly Ser Leu Ser Leu Ser 
            740                 745                 750         
Thr Leu Glu Thr Val Lys Ala Val Lys Gly Ile Ile Tyr Ser Tyr Phe 
        755                 760                 765             
Ser Thr Ala Leu Asn Ala Ser Lys Asn Asn Pro Ile Ser Asp Glu Gln 
    770                 775                 780                 
Arg Lys Glu Phe Asp Pro Glu Leu Phe Ala Leu Leu Glu Lys Leu Glu 
785                 790                 795                 800 
Leu Ile Arg Thr Arg Lys Lys Lys Gln Lys Val Glu Arg Ile Ala Asn 
                805                 810                 815     
Ser Leu Ile Gln Thr Cys Leu Glu Asn Asn Ile Lys Phe Ile Arg Gly 
            820                 825                 830         
Glu Gly Asp Leu Ser Thr Thr Asn Asn Ala Thr Lys Lys Lys Ala Asn 
        835                 840                 845             
Ser Arg Ser Met Asp Trp Leu Ala Arg Gly Val Phe Asn Lys Ile Arg 
    850                 855                 860                 
Gln Leu Ala Pro Met His Asn Ile Thr Leu Phe Gly Cys Gly Ser Leu 
865                 870                 875                 880 
Tyr Thr Ser His Gln Asp Pro Leu Val His Arg Asn Pro Asp Lys Ala 
                885                 890                 895     
Met Lys Cys Arg Trp Ala Ala Ile Pro Val Lys Asp Ile Gly Asp Trp 
            900                 905                 910         
Val Leu Arg Lys Leu Ser Gln Asn Leu Arg Ala Lys Asn Arg Gly Thr 
        915                 920                 925             
Gly Glu Tyr Tyr His Gln Gly Val Lys Glu Phe Leu Ser His Tyr Glu 
    930                 935                 940                 
Leu Gln Asp Leu Glu Glu Glu Leu Leu Lys Trp Arg Ser Asp Arg Lys 
945                 950                 955                 960 
Ser Asn Ile Pro Cys Trp Val Leu Gln Asn Arg Leu Ala Glu Lys Leu 
                965                 970                 975     
Gly Asn Lys Glu Ala Val Val Tyr Ile Pro Val Arg Gly Gly Arg Ile 
            980                 985                 990         
Tyr Phe Ala Thr His Lys Val Ala  Thr Gly Ala Val Ser  Ile Val Phe 
        995                 1000                 1005             
Asp Gln  Lys Gln Val Trp Val  Cys Asn Ala Asp His  Val Ala Ala Ala 
    1010                 1015                 1020                 
Asn  Ile Ala Leu Thr Val  Lys Gly Ile Gly Glu  Gln Ser Ser Asp Glu  
1025                 1030                 1035                 1040 
Glu Asn Pro Asp Gly  Ser Arg Ile Lys Leu  Gln Leu Thr Ser 
                1045                 1050                 

<210>  4
<211>  1054
<212>  PRT
<213>  Artificial Sequence

<400>  4
Met Ser Ser Ala Ile Lys Ser Tyr Lys Ser Val Leu Arg Pro Asn Glu 
1               5                   10                  15      
Arg Lys Asn Gln Leu Leu Lys Ser Thr Ile Gln Cys Leu Glu Asp Gly 
            20                  25                  30          
Ser Ala Phe Phe Phe Lys Met Leu Gln Gly Leu Phe Gly Gly Ile Thr 
        35                  40                  45              
Pro Glu Ile Val Arg Phe Ser Thr Glu Gln Glu Lys Gln Gln Gln Asp 
    50                  55                  60                  
Ile Ala Leu Trp Cys Ala Val Asn Trp Phe Arg Pro Val Ser Gln Asp 
65                  70                  75                  80  
Ser Leu Thr His Thr Ile Ala Ser Asp Asn Leu Val Glu Lys Phe Glu 
                85                  90                  95      
Glu Tyr Tyr Gly Gly Thr Ala Ser Asp Ala Ile Lys Gln Tyr Phe Ser 
            100                 105                 110         
Ala Ser Ile Gly Glu Ser Tyr Tyr Trp Asn Asp Cys Arg Gln Gln Tyr 
        115                 120                 125             
Tyr Asp Leu Cys Arg Glu Leu Gly Val Glu Val Ser Asp Leu Thr His 
    130                 135                 140                 
Asp Leu Glu Ile Leu Cys Arg Glu Lys Cys Leu Ala Val Ala Thr Glu 
145                 150                 155                 160 
Ser Asn Gln Asn Asn Ser Ile Ile Ser Val Leu Phe Gly Thr Gly Arg 
                165                 170                 175     
Lys Glu Asp Arg Ser Val Lys Leu Arg Ile Thr Lys Lys Ile Leu Glu 
            180                 185                 190         
Ala Ile Ser Asn Leu Lys Glu Ile Pro Lys Asn Val Ala Pro Ile Gln 
        195                 200                 205             
Glu Ile Ile Leu Asn Val Ala Lys Ala Thr Lys Glu Thr Phe Arg Gln 
    210                 215                 220                 
Val Tyr Ala Gly Asn Leu Gly Ala Pro Ser Thr Leu Glu Arg Phe Ile 
225                 230                 235                 240 
Ala Lys Asp Gly Gln Lys Glu Phe Asp Leu Lys Lys Leu Gln Thr Asp 
                245                 250                 255     
Leu Lys Lys Val Ile Arg Gly Lys Ser Lys Glu Arg Asp Trp Cys Cys 
            260                 265                 270         
Gln Glu Glu Leu Arg Ser Tyr Val Glu Gln Asn Thr Ile Gln Tyr Asp 
        275                 280                 285             
Leu Trp Ala Trp Gly Glu Met Phe Asn Lys Ala His Thr Ala Leu Lys 
    290                 295                 300                 
Ile Lys Ser Thr Arg Asn Tyr Asn Phe Ala Lys Gln Arg Leu Glu Gln 
305                 310                 315                 320 
Phe Lys Arg Ile Gln Ser Leu Asn Asn Leu Leu Val Val Lys Lys Leu 
                325                 330                 335     
Asn Asp Phe Phe Asp Ser Glu Phe Phe Ser Gly Glu Glu Thr Tyr Thr 
            340                 345                 350         
Ile Cys Val His His Leu Gly Gly Lys Arg Leu Ser Lys Leu Tyr Lys 
        355                 360                 365             
Ala Trp Glu Asp Asp Pro Ala Asp Pro Glu Asn Ala Ile Val Val Leu 
    370                 375                 380                 
Cys Asp Asp Leu Lys Asn Asn Phe Lys Lys Glu Pro Ile Arg Asn Ile 
385                 390                 395                 400 
Leu Arg Tyr Ile Phe Thr Ile Arg Gln Glu Cys Ser Ala Gln Asp Ile 
                405                 410                 415     
Leu Ala Ala Ala Lys Tyr Asn Gln Gln Leu Asp Arg Tyr Lys Ser Gln 
            420                 425                 430         
Lys Ala Asn Pro Ser Val Leu Gly Asn Gln Gly Phe Thr Trp Arg Asn 
        435                 440                 445             
Ala Val Ile Leu Pro Glu Lys Ala Gln Arg Asn Asp Arg Pro Asn Ser 
    450                 455                 460                 
Leu Asp Leu Arg Ile Trp Leu Tyr Leu Lys Leu Arg His Pro Asp Gly 
465                 470                 475                 480 
Arg Trp Lys Lys His His Ile Pro Phe Tyr Asp Thr Arg Phe Phe Gln 
                485                 490                 495     
Glu Ile Tyr Ala Ala Gly Asn Ser Pro Val Asp Thr Cys Gln Phe Arg 
            500                 505                 510         
Thr Pro Arg Phe Gly Tyr His Leu Pro Lys Leu Thr Asp Gln Thr Ala 
        515                 520                 525             
Ile Arg Val Asn Lys Lys His Val Lys Ala Ala Lys Thr Glu Ala Arg 
    530                 535                 540                 
Ile Arg Leu Ala Ile Gln Gln Gly Thr Leu Pro Val Ser Asn Leu Lys 
545                 550                 555                 560 
Ile Thr Arg Ile Ser Ala Thr Ile Asn Ser Lys Gly Gln Val Arg Ile 
                565                 570                 575     
Pro Val Lys Phe Asp Val Gly Arg Gln Lys Gly Thr Leu Gln Ile Gly 
            580                 585                 590         
Asp Arg Phe Cys Gly Tyr Asp Gln Asn Gln Thr Ala Ser His Ala Tyr 
        595                 600                 605             
Ser Leu Trp Glu Val Val Lys Glu Gly Gln Tyr His Lys Glu Leu Gly 
    610                 615                 620                 
Cys Phe Val Arg Phe Ile Ser Ser Gly Asp Ile Val Ser Ile Thr Glu 
625                 630                 635                 640 
Asn Arg Gly Asn Gln Phe Asp Gln Leu Ser Tyr Glu Gly Leu Ala Tyr 
                645                 650                 655     
Pro Gln Tyr Ala Asp Trp Arg Lys Lys Ala Ser Lys Phe Val Ser Leu 
            660                 665                 670         
Trp Gln Ile Thr Lys Lys Asn Lys Lys Lys Glu Ile Val Thr Val Glu 
        675                 680                 685             
Ala Lys Glu Lys Phe Asp Ala Ile Cys Lys Tyr Gln Pro Arg Leu Tyr 
    690                 695                 700                 
Lys Phe Asn Lys Glu Tyr Ala Tyr Leu Leu Arg Asp Ile Val Arg Gly 
705                 710                 715                 720 
Lys Ser Leu Val Glu Leu Gln Gln Ile Arg Gln Glu Ile Phe Arg Phe 
                725                 730                 735     
Ile Glu Gln Asp Cys Gly Val Thr Arg Leu Gly Ser Leu Ser Leu Ser 
            740                 745                 750         
Thr Leu Glu Thr Val Lys Ala Val Lys Gly Ile Ile Tyr Ser Tyr Phe 
        755                 760                 765             
Ser Thr Ala Leu Asn Ala Ser Lys Asn Asn Pro Ile Ser Asp Glu Gln 
    770                 775                 780                 
Arg Lys Glu Phe Asp Pro Glu Leu Phe Ala Leu Leu Glu Lys Leu Glu 
785                 790                 795                 800 
Leu Ile Arg Thr Arg Lys Lys Lys Gln Lys Val Glu Arg Ile Ala Asn 
                805                 810                 815     
Ser Leu Ile Gln Thr Cys Leu Glu Asn Asn Ile Lys Phe Ile Arg Gly 
            820                 825                 830         
Glu Gly Asp Leu Ser Thr Thr Asn Asn Ala Thr Lys Lys Lys Ala Asn 
        835                 840                 845             
Ser Arg Ser Met Asp Trp Leu Ala Arg Gly Val Phe Asn Lys Ile Arg 
    850                 855                 860                 
Gln Leu Ala Pro Met His Asn Ile Thr Leu Phe Gly Cys Gly Ser Leu 
865                 870                 875                 880 
Tyr Thr Ser His Gln Asp Pro Leu Val His Arg Asn Pro Asp Lys Ala 
                885                 890                 895     
Met Lys Cys Arg Trp Ala Ala Ile Pro Val Lys Asp Ile Gly Asp Trp 
            900                 905                 910         
Val Leu Arg Lys Leu Ser Gln Asn Leu Arg Ala Lys Asn Ile Gly Thr 
        915                 920                 925             
Gly Glu Tyr Tyr His Gln Gly Val Lys Glu Phe Leu Ser His Tyr Glu 
    930                 935                 940                 
Leu Gln Asp Leu Glu Glu Glu Leu Leu Lys Trp Arg Ser Asp Arg Lys 
945                 950                 955                 960 
Ser Asn Ile Pro Cys Trp Val Leu Gln Asn Arg Leu Ala Glu Lys Leu 
                965                 970                 975     
Gly Asn Lys Glu Ala Val Val Tyr Ile Pro Val Arg Gly Gly Arg Ile 
            980                 985                 990         
Tyr Phe Ala Thr His Lys Val Ala  Thr Gly Ala Val Ser  Ile Val Phe 
        995                 1000                 1005             
Asp Gln  Lys Gln Val Trp Val  Cys Asn Ala Asp His  Val Ala Ala Ala 
    1010                 1015                 1020                 
Asn  Ile Ala Leu Thr Val  Lys Gly Ile Gly Glu  Gln Ser Ser Asp Glu  
1025                 1030                 1035                 1040 
Glu Asn Pro Asp Gly  Ser Arg Ile Lys Leu  Gln Leu Thr Ser 
                1045                 1050                 

<210>  5
<211>  1054
<212>  PRT
<213>  Artificial Sequence

<400>  5
Met Ser Ser Ala Ile Lys Ser Tyr Lys Ser Val Leu Arg Pro Asn Glu 
1               5                   10                  15      
Arg Lys Asn Gln Leu Leu Lys Ser Thr Ile Gln Cys Leu Glu Asp Gly 
            20                  25                  30          
Ser Ala Phe Phe Phe Lys Met Leu Gln Gly Leu Phe Gly Gly Ile Thr 
        35                  40                  45              
Pro Glu Ile Val Arg Phe Ser Thr Glu Gln Glu Lys Gln Gln Gln Asp 
    50                  55                  60                  
Ile Ala Leu Trp Cys Ala Val Asn Trp Phe Arg Pro Val Ser Gln Asp 
65                  70                  75                  80  
Ser Leu Thr His Thr Ile Ala Ser Asp Asn Leu Val Glu Lys Phe Glu 
                85                  90                  95      
Glu Tyr Tyr Gly Gly Thr Ala Ser Asp Ala Ile Lys Gln Tyr Phe Ser 
            100                 105                 110         
Ala Ser Ile Gly Glu Ser Tyr Tyr Trp Asn Asp Cys Arg Gln Gln Tyr 
        115                 120                 125             
Tyr Asp Leu Cys Arg Glu Leu Gly Val Glu Val Ser Asp Leu Thr His 
    130                 135                 140                 
Asp Leu Glu Ile Leu Cys Arg Glu Lys Cys Leu Ala Val Ala Thr Glu 
145                 150                 155                 160 
Ser Asn Gln Tyr Asn Ser Ile Ile Ser Val Leu Phe Gly Thr Gly Glu 
                165                 170                 175     
Lys Glu Asp Arg Ser Val Lys Leu Arg Ile Thr Lys Lys Ile Leu Glu 
            180                 185                 190         
Ala Ile Ser Asn Leu Lys Glu Ile Pro Lys Asn Val Ala Pro Ile Gln 
        195                 200                 205             
Glu Ile Ile Leu Asn Val Ala Lys Ala Thr Lys Glu Thr Phe Arg Gln 
    210                 215                 220                 
Val Tyr Ala Gly Asn Leu Gly Ala Pro Ser Thr Leu Glu Lys Phe Ile 
225                 230                 235                 240 
Ala Lys Asp Gly Gln Lys Glu Phe Asp Leu Lys Lys Leu Gln Thr Asp 
                245                 250                 255     
Leu Lys Lys Val Ile Arg Gly Lys Ser Lys Glu Arg Asp Trp Cys Cys 
            260                 265                 270         
Gln Glu Glu Leu Arg Ser Tyr Val Glu Gln Asn Thr Ile Gln Tyr Asp 
        275                 280                 285             
Leu Trp Ala Trp Gly Glu Met Phe Asn Lys Ala His Thr Ala Leu Lys 
    290                 295                 300                 
Ile Lys Ser Thr Arg Asn Tyr Asn Phe Ala Lys Gln Arg Leu Glu Gln 
305                 310                 315                 320 
Phe Lys Glu Ile Gln Ser Leu Asn Asn Leu Leu Val Val Lys Lys Leu 
                325                 330                 335     
Asn Asp Phe Phe Asp Ser Glu Phe Phe Ser Gly Glu Glu Thr Tyr Thr 
            340                 345                 350         
Ile Cys Val His His Leu Gly Gly Lys Asp Leu Ser Lys Leu Tyr Lys 
        355                 360                 365             
Ala Trp Glu Asp Asp Pro Ala Asp Pro Glu Asn Ala Ile Val Val Leu 
    370                 375                 380                 
Cys Asp Asp Leu Lys Asn Asn Phe Lys Lys Glu Pro Ile Arg Asn Ile 
385                 390                 395                 400 
Leu Arg Tyr Ile Phe Thr Ile Arg Gln Glu Cys Ser Ala Gln Asp Ile 
                405                 410                 415     
Leu Ala Ala Ala Lys Tyr Asn Gln Gln Leu Asp Arg Tyr Lys Ser Gln 
            420                 425                 430         
Lys Ala Asn Pro Ser Val Leu Gly Asn Gln Gly Phe Thr Trp Thr Asn 
        435                 440                 445             
Ala Val Ile Leu Pro Glu Lys Ala Gln Arg Asn Asp Arg Pro Asn Ser 
    450                 455                 460                 
Leu Asp Leu Arg Ile Trp Leu Tyr Leu Lys Leu Arg His Pro Asp Gly 
465                 470                 475                 480 
Arg Trp Lys Lys His His Ile Pro Phe Tyr Asp Thr Arg Phe Phe Gln 
                485                 490                 495     
Glu Ile Tyr Ala Ala Gly Asn Ser Pro Val Asp Thr Cys Gln Phe Arg 
            500                 505                 510         
Thr Pro Arg Phe Gly Tyr His Leu Pro Lys Leu Thr Asp Gln Thr Ala 
        515                 520                 525             
Ile Arg Val Asn Lys Lys His Val Lys Ala Ala Lys Thr Glu Ala Arg 
    530                 535                 540                 
Ile Arg Leu Ala Ile Gln Gln Gly Thr Leu Pro Val Ser Asn Leu Lys 
545                 550                 555                 560 
Ile Thr Glu Ile Ser Ala Thr Ile Asn Ser Lys Gly Gln Val Arg Ile 
                565                 570                 575     
Pro Val Lys Phe Asp Val Gly Arg Gln Lys Gly Thr Leu Gln Ile Gly 
            580                 585                 590         
Asp Arg Phe Cys Gly Tyr Asp Gln Asn Gln Thr Ala Ser His Ala Tyr 
        595                 600                 605             
Ser Leu Trp Glu Val Val Lys Glu Gly Gln Tyr His Lys Glu Leu Gly 
    610                 615                 620                 
Cys Phe Val Arg Phe Ile Ser Ser Gly Asp Ile Val Ser Ile Thr Glu 
625                 630                 635                 640 
Asn Arg Gly Asn Gln Phe Asp Gln Leu Ser Tyr Glu Gly Leu Ala Tyr 
                645                 650                 655     
Pro Gln Tyr Ala Asp Trp Arg Lys Lys Ala Ser Lys Phe Val Ser Leu 
            660                 665                 670         
Trp Gln Ile Thr Lys Lys Asn Lys Lys Lys Glu Ile Val Thr Val Glu 
        675                 680                 685             
Ala Lys Glu Lys Phe Asp Ala Ile Cys Lys Tyr Gln Pro Arg Leu Tyr 
    690                 695                 700                 
Lys Phe Asn Lys Glu Tyr Ala Tyr Leu Leu Arg Asp Ile Val Arg Gly 
705                 710                 715                 720 
Lys Ser Leu Val Glu Leu Gln Gln Ile Arg Gln Glu Ile Phe Arg Phe 
                725                 730                 735     
Ile Glu Gln Asp Cys Gly Val Thr Arg Leu Gly Ser Leu Ser Leu Ser 
            740                 745                 750         
Thr Leu Glu Thr Val Lys Ala Val Lys Gly Ile Ile Tyr Ser Tyr Phe 
        755                 760                 765             
Ser Thr Ala Leu Asn Ala Ser Lys Asn Asn Pro Ile Ser Asp Glu Gln 
    770                 775                 780                 
Arg Lys Glu Phe Asp Pro Glu Leu Phe Ala Leu Leu Glu Lys Leu Glu 
785                 790                 795                 800 
Leu Ile Arg Thr Arg Lys Lys Lys Gln Lys Val Glu Arg Ile Ala Asn 
                805                 810                 815     
Ser Leu Ile Gln Thr Cys Leu Glu Asn Asn Ile Lys Phe Ile Arg Gly 
            820                 825                 830         
Glu Gly Asp Leu Ser Thr Thr Asn Asn Ala Thr Lys Lys Lys Ala Asn 
        835                 840                 845             
Ser Arg Ser Met Asp Trp Leu Ala Arg Gly Val Phe Asn Lys Ile Arg 
    850                 855                 860                 
Gln Leu Ala Pro Met His Asn Ile Thr Leu Phe Gly Cys Gly Ser Leu 
865                 870                 875                 880 
Tyr Thr Ser His Gln Asp Pro Leu Val His Arg Asn Pro Asp Lys Ala 
                885                 890                 895     
Met Lys Cys Arg Trp Ala Ala Ile Pro Val Lys Asp Ile Gly Asp Trp 
            900                 905                 910         
Val Leu Arg Lys Leu Ser Gln Asn Leu Arg Ala Lys Asn Arg Gly Thr 
        915                 920                 925             
Gly Glu Tyr Tyr His Gln Gly Val Lys Glu Phe Leu Ser His Tyr Glu 
    930                 935                 940                 
Leu Gln Asp Leu Glu Glu Glu Leu Leu Lys Trp Arg Ser Asp Arg Lys 
945                 950                 955                 960 
Ser Asn Ile Pro Cys Trp Val Leu Gln Asn Arg Leu Ala Glu Lys Leu 
                965                 970                 975     
Gly Asn Lys Glu Ala Val Val Tyr Ile Pro Val Arg Gly Gly Arg Ile 
            980                 985                 990         
Tyr Phe Ala Thr His Lys Val Ala  Thr Gly Ala Val Ser  Ile Val Phe 
        995                 1000                 1005             
Asp Gln  Lys Gln Val Trp Val  Cys Asn Ala Asp His  Val Ala Ala Ala 
    1010                 1015                 1020                 
Asn  Ile Ala Leu Thr Val  Lys Gly Ile Gly Glu  Gln Ser Ser Asp Glu  
1025                 1030                 1035                 1040 
Glu Asn Pro Asp Gly  Ser Arg Ile Lys Leu  Gln Leu Thr Ser 
                1045                 1050                 

<210>  6
<211>  1054
<212>  PRT
<213>  Artificial Sequence

<400>  6
Met Ser Ser Ala Ile Lys Ser Tyr Lys Ser Val Leu Arg Pro Asn Glu 
1               5                   10                  15      
Arg Lys Asn Gln Leu Leu Lys Ser Thr Ile Gln Cys Leu Glu Asp Gly 
            20                  25                  30          
Ser Ala Phe Phe Phe Lys Met Leu Gln Gly Leu Phe Gly Gly Ile Thr 
        35                  40                  45              
Pro Glu Ile Val Arg Phe Ser Thr Glu Gln Glu Lys Gln Gln Gln Asp 
    50                  55                  60                  
Ile Ala Leu Trp Cys Ala Val Asn Trp Phe Arg Pro Val Ser Gln Asp 
65                  70                  75                  80  
Ser Leu Thr His Thr Ile Ala Ser Asp Asn Leu Val Glu Lys Phe Glu 
                85                  90                  95      
Glu Tyr Tyr Gly Gly Thr Ala Ser Asp Ala Ile Lys Gln Tyr Phe Ser 
            100                 105                 110         
Ala Ser Ile Gly Glu Ser Tyr Tyr Trp Asn Asp Cys Arg Gln Gln Tyr 
        115                 120                 125             
Tyr Asp Leu Cys Arg Glu Leu Gly Val Glu Val Ser Asp Leu Thr His 
    130                 135                 140                 
Asp Leu Glu Ile Leu Cys Arg Glu Lys Cys Leu Ala Val Ala Thr Glu 
145                 150                 155                 160 
Ser Asn Gln Tyr Asn Ser Ile Ile Ser Val Leu Phe Gly Thr Gly Glu 
                165                 170                 175     
Lys Glu Asp Arg Ser Val Lys Leu Arg Ile Thr Lys Lys Ile Leu Glu 
            180                 185                 190         
Ala Ile Ser Asn Leu Lys Glu Ile Pro Lys Asn Val Ala Pro Ile Gln 
        195                 200                 205             
Glu Ile Ile Leu Asn Val Ala Lys Ala Thr Lys Glu Thr Phe Arg Gln 
    210                 215                 220                 
Val Tyr Ala Gly Asn Leu Gly Ala Pro Ser Thr Leu Glu Lys Phe Ile 
225                 230                 235                 240 
Ala Lys Asp Gly Gln Lys Glu Phe Asp Leu Lys Lys Leu Gln Thr Asp 
                245                 250                 255     
Leu Lys Lys Val Ile Arg Gly Lys Ser Lys Glu Arg Asp Trp Cys Cys 
            260                 265                 270         
Gln Glu Glu Leu Arg Ser Tyr Val Glu Gln Asn Thr Ile Gln Tyr Asp 
        275                 280                 285             
Leu Trp Ala Trp Gly Glu Met Phe Asn Lys Ala His Thr Ala Leu Lys 
    290                 295                 300                 
Ile Lys Ser Thr Arg Asn Tyr Asn Phe Ala Lys Gln Arg Leu Glu Gln 
305                 310                 315                 320 
Phe Lys Arg Ile Gln Ser Leu Asn Asn Leu Leu Val Val Lys Lys Leu 
                325                 330                 335     
Asn Asp Phe Phe Asp Ser Glu Phe Phe Ser Gly Glu Glu Thr Tyr Thr 
            340                 345                 350         
Ile Cys Val His His Leu Gly Gly Lys Arg Leu Ser Lys Leu Tyr Lys 
        355                 360                 365             
Ala Trp Glu Asp Asp Pro Ala Asp Pro Glu Asn Ala Ile Val Val Leu 
    370                 375                 380                 
Cys Asp Asp Leu Lys Asn Asn Phe Lys Lys Glu Pro Ile Arg Asn Ile 
385                 390                 395                 400 
Leu Arg Tyr Ile Phe Thr Ile Arg Gln Glu Cys Ser Ala Gln Asp Ile 
                405                 410                 415     
Leu Ala Ala Ala Lys Tyr Asn Gln Gln Leu Asp Arg Tyr Lys Ser Gln 
            420                 425                 430         
Lys Ala Asn Pro Ser Val Leu Gly Asn Gln Gly Phe Thr Trp Thr Asn 
        435                 440                 445             
Ala Val Ile Leu Pro Glu Lys Ala Gln Arg Asn Asp Arg Pro Asn Ser 
    450                 455                 460                 
Leu Asp Leu Arg Ile Trp Leu Tyr Leu Lys Leu Arg His Pro Asp Gly 
465                 470                 475                 480 
Arg Trp Lys Lys His His Ile Pro Phe Tyr Asp Thr Arg Phe Phe Gln 
                485                 490                 495     
Glu Ile Tyr Ala Ala Gly Asn Ser Pro Val Asp Thr Cys Gln Phe Arg 
            500                 505                 510         
Thr Pro Arg Phe Gly Tyr His Leu Pro Lys Leu Thr Asp Gln Thr Ala 
        515                 520                 525             
Ile Arg Val Asn Lys Lys His Val Lys Ala Ala Lys Thr Glu Ala Arg 
    530                 535                 540                 
Ile Arg Leu Ala Ile Gln Gln Gly Thr Leu Pro Val Ser Asn Leu Lys 
545                 550                 555                 560 
Ile Thr Glu Ile Ser Ala Thr Ile Asn Ser Lys Gly Gln Val Arg Ile 
                565                 570                 575     
Pro Val Lys Phe Asp Val Gly Arg Gln Lys Gly Thr Leu Gln Ile Gly 
            580                 585                 590         
Asp Arg Phe Cys Gly Tyr Asp Gln Asn Gln Thr Ala Ser His Ala Tyr 
        595                 600                 605             
Ser Leu Trp Glu Val Val Lys Glu Gly Gln Tyr His Lys Glu Leu Gly 
    610                 615                 620                 
Cys Phe Val Arg Phe Ile Ser Ser Gly Asp Ile Val Ser Ile Thr Glu 
625                 630                 635                 640 
Asn Arg Gly Asn Gln Phe Asp Gln Leu Ser Tyr Glu Gly Leu Ala Tyr 
                645                 650                 655     
Pro Gln Tyr Ala Asp Trp Arg Lys Lys Ala Ser Lys Phe Val Ser Leu 
            660                 665                 670         
Trp Gln Ile Thr Lys Lys Asn Lys Lys Lys Glu Ile Val Thr Val Glu 
        675                 680                 685             
Ala Lys Glu Lys Phe Asp Ala Ile Cys Lys Tyr Gln Pro Arg Leu Tyr 
    690                 695                 700                 
Lys Phe Asn Lys Glu Tyr Ala Tyr Leu Leu Arg Asp Ile Val Arg Gly 
705                 710                 715                 720 
Lys Ser Leu Val Glu Leu Gln Gln Ile Arg Gln Glu Ile Phe Arg Phe 
                725                 730                 735     
Ile Glu Gln Asp Cys Gly Val Thr Arg Leu Gly Ser Leu Ser Leu Ser 
            740                 745                 750         
Thr Leu Glu Thr Val Lys Ala Val Lys Gly Ile Ile Tyr Ser Tyr Phe 
        755                 760                 765             
Ser Thr Ala Leu Asn Ala Ser Lys Asn Asn Pro Ile Ser Asp Glu Gln 
    770                 775                 780                 
Arg Lys Glu Phe Asp Pro Glu Leu Phe Ala Leu Leu Glu Lys Leu Glu 
785                 790                 795                 800 
Leu Ile Arg Thr Arg Lys Lys Lys Gln Lys Val Glu Arg Ile Ala Asn 
                805                 810                 815     
Ser Leu Ile Gln Thr Cys Leu Glu Asn Asn Ile Lys Phe Ile Arg Gly 
            820                 825                 830         
Glu Gly Asp Leu Ser Thr Thr Asn Asn Ala Thr Lys Lys Lys Ala Asn 
        835                 840                 845             
Ser Arg Ser Met Asp Trp Leu Ala Arg Gly Val Phe Asn Lys Ile Arg 
    850                 855                 860                 
Gln Leu Ala Pro Met His Asn Ile Thr Leu Phe Gly Cys Gly Ser Leu 
865                 870                 875                 880 
Tyr Thr Ser His Gln Asp Pro Leu Val His Arg Asn Pro Asp Lys Ala 
                885                 890                 895     
Met Lys Cys Arg Trp Ala Ala Ile Pro Val Lys Asp Ile Gly Asp Trp 
            900                 905                 910         
Val Leu Arg Lys Leu Ser Gln Asn Leu Arg Ala Lys Asn Ile Gly Thr 
        915                 920                 925             
Gly Glu Tyr Tyr His Gln Gly Val Lys Glu Phe Leu Ser His Tyr Glu 
    930                 935                 940                 
Leu Gln Asp Leu Glu Glu Glu Leu Leu Lys Trp Arg Ser Asp Arg Lys 
945                 950                 955                 960 
Ser Asn Ile Pro Cys Trp Val Leu Gln Asn Arg Leu Ala Glu Lys Leu 
                965                 970                 975     
Gly Asn Lys Glu Ala Val Val Tyr Ile Pro Val Arg Gly Gly Arg Ile 
            980                 985                 990         
Tyr Phe Ala Thr His Lys Val Ala  Thr Gly Ala Val Ser  Ile Val Phe 
        995                 1000                 1005             
Asp Gln  Lys Gln Val Trp Val  Cys Asn Ala Asp His  Val Ala Ala Ala 
    1010                 1015                 1020                 
Asn  Ile Ala Leu Thr Val  Lys Gly Ile Gly Glu  Gln Ser Ser Asp Glu  
1025                 1030                 1035                 1040 
Glu Asn Pro Asp Gly  Ser Arg Ile Lys Leu  Gln Leu Thr Ser 
                1045                 1050                 

<210>  7
<211>  1054
<212>  PRT
<213>  Artificial Sequence

<400>  7
Met Ser Ser Ala Ile Lys Ser Tyr Lys Ser Val Leu Arg Pro Asn Glu 
1               5                   10                  15      
Arg Lys Asn Gln Leu Leu Lys Ser Thr Ile Gln Cys Leu Glu Asp Gly 
            20                  25                  30          
Ser Ala Phe Phe Phe Lys Met Leu Gln Gly Leu Phe Gly Gly Ile Thr 
        35                  40                  45              
Pro Glu Ile Val Arg Phe Ser Thr Glu Gln Glu Lys Gln Gln Gln Asp 
    50                  55                  60                  
Ile Ala Leu Trp Cys Ala Val Asn Trp Phe Arg Pro Val Ser Gln Asp 
65                  70                  75                  80  
Ser Leu Thr His Thr Ile Ala Ser Asp Asn Leu Val Glu Lys Phe Glu 
                85                  90                  95      
Glu Tyr Tyr Gly Gly Thr Ala Ser Asp Ala Ile Lys Gln Tyr Phe Ser 
            100                 105                 110         
Ala Ser Ile Gly Glu Ser Tyr Tyr Trp Asn Asp Cys Arg Gln Gln Tyr 
        115                 120                 125             
Tyr Asp Leu Cys Arg Glu Leu Gly Val Glu Val Ser Asp Leu Thr His 
    130                 135                 140                 
Asp Leu Glu Ile Leu Cys Arg Glu Lys Cys Leu Ala Val Ala Thr Glu 
145                 150                 155                 160 
Ser Asn Gln Tyr Asn Ser Ile Ile Ser Val Leu Phe Gly Thr Gly Arg 
                165                 170                 175     
Lys Glu Asp Arg Ser Val Lys Leu Arg Ile Thr Lys Lys Ile Leu Glu 
            180                 185                 190         
Ala Ile Ser Asn Leu Lys Glu Ile Pro Lys Asn Val Ala Pro Ile Gln 
        195                 200                 205             
Glu Ile Ile Leu Asn Val Ala Lys Ala Thr Lys Glu Thr Phe Arg Gln 
    210                 215                 220                 
Val Tyr Ala Gly Asn Leu Gly Ala Pro Ser Thr Leu Glu Arg Phe Ile 
225                 230                 235                 240 
Ala Lys Asp Gly Gln Lys Glu Phe Asp Leu Lys Lys Leu Gln Thr Asp 
                245                 250                 255     
Leu Lys Lys Val Ile Arg Gly Lys Ser Lys Glu Arg Asp Trp Cys Cys 
            260                 265                 270         
Gln Glu Glu Leu Arg Ser Tyr Val Glu Gln Asn Thr Ile Gln Tyr Asp 
        275                 280                 285             
Leu Trp Ala Trp Gly Glu Met Phe Asn Lys Ala His Thr Ala Leu Lys 
    290                 295                 300                 
Ile Lys Ser Thr Arg Asn Tyr Asn Phe Ala Lys Gln Arg Leu Glu Gln 
305                 310                 315                 320 
Phe Lys Glu Ile Gln Ser Leu Asn Asn Leu Leu Val Val Lys Lys Leu 
                325                 330                 335     
Asn Asp Phe Phe Asp Ser Glu Phe Phe Ser Gly Glu Glu Thr Tyr Thr 
            340                 345                 350         
Ile Cys Val His His Leu Gly Gly Lys Asp Leu Ser Lys Leu Tyr Lys 
        355                 360                 365             
Ala Trp Glu Asp Asp Pro Ala Asp Pro Glu Asn Ala Ile Val Val Leu 
    370                 375                 380                 
Cys Asp Asp Leu Lys Asn Asn Phe Lys Lys Glu Pro Ile Arg Asn Ile 
385                 390                 395                 400 
Leu Arg Tyr Ile Phe Thr Ile Arg Gln Glu Cys Ser Ala Gln Asp Ile 
                405                 410                 415     
Leu Ala Ala Ala Lys Tyr Asn Gln Gln Leu Asp Arg Tyr Lys Ser Gln 
            420                 425                 430         
Lys Ala Asn Pro Ser Val Leu Gly Asn Gln Gly Phe Thr Trp Arg Asn 
        435                 440                 445             
Ala Val Ile Leu Pro Glu Lys Ala Gln Arg Asn Asp Arg Pro Asn Ser 
    450                 455                 460                 
Leu Asp Leu Arg Ile Trp Leu Tyr Leu Lys Leu Arg His Pro Asp Gly 
465                 470                 475                 480 
Arg Trp Lys Lys His His Ile Pro Phe Tyr Asp Thr Arg Phe Phe Gln 
                485                 490                 495     
Glu Ile Tyr Ala Ala Gly Asn Ser Pro Val Asp Thr Cys Gln Phe Arg 
            500                 505                 510         
Thr Pro Arg Phe Gly Tyr His Leu Pro Lys Leu Thr Asp Gln Thr Ala 
        515                 520                 525             
Ile Arg Val Asn Lys Lys His Val Lys Ala Ala Lys Thr Glu Ala Arg 
    530                 535                 540                 
Ile Arg Leu Ala Ile Gln Gln Gly Thr Leu Pro Val Ser Asn Leu Lys 
545                 550                 555                 560 
Ile Thr Arg Ile Ser Ala Thr Ile Asn Ser Lys Gly Gln Val Arg Ile 
                565                 570                 575     
Pro Val Lys Phe Asp Val Gly Arg Gln Lys Gly Thr Leu Gln Ile Gly 
            580                 585                 590         
Asp Arg Phe Cys Gly Tyr Asp Gln Asn Gln Thr Ala Ser His Ala Tyr 
        595                 600                 605             
Ser Leu Trp Glu Val Val Lys Glu Gly Gln Tyr His Lys Glu Leu Gly 
    610                 615                 620                 
Cys Phe Val Arg Phe Ile Ser Ser Gly Asp Ile Val Ser Ile Thr Glu 
625                 630                 635                 640 
Asn Arg Gly Asn Gln Phe Asp Gln Leu Ser Tyr Glu Gly Leu Ala Tyr 
                645                 650                 655     
Pro Gln Tyr Ala Asp Trp Arg Lys Lys Ala Ser Lys Phe Val Ser Leu 
            660                 665                 670         
Trp Gln Ile Thr Lys Lys Asn Lys Lys Lys Glu Ile Val Thr Val Glu 
        675                 680                 685             
Ala Lys Glu Lys Phe Asp Ala Ile Cys Lys Tyr Gln Pro Arg Leu Tyr 
    690                 695                 700                 
Lys Phe Asn Lys Glu Tyr Ala Tyr Leu Leu Arg Asp Ile Val Arg Gly 
705                 710                 715                 720 
Lys Ser Leu Val Glu Leu Gln Gln Ile Arg Gln Glu Ile Phe Arg Phe 
                725                 730                 735     
Ile Glu Gln Asp Cys Gly Val Thr Arg Leu Gly Ser Leu Ser Leu Ser 
            740                 745                 750         
Thr Leu Glu Thr Val Lys Ala Val Lys Gly Ile Ile Tyr Ser Tyr Phe 
        755                 760                 765             
Ser Thr Ala Leu Asn Ala Ser Lys Asn Asn Pro Ile Ser Asp Glu Gln 
    770                 775                 780                 
Arg Lys Glu Phe Asp Pro Glu Leu Phe Ala Leu Leu Glu Lys Leu Glu 
785                 790                 795                 800 
Leu Ile Arg Thr Arg Lys Lys Lys Gln Lys Val Glu Arg Ile Ala Asn 
                805                 810                 815     
Ser Leu Ile Gln Thr Cys Leu Glu Asn Asn Ile Lys Phe Ile Arg Gly 
            820                 825                 830         
Glu Gly Asp Leu Ser Thr Thr Asn Asn Ala Thr Lys Lys Lys Ala Asn 
        835                 840                 845             
Ser Arg Ser Met Asp Trp Leu Ala Arg Gly Val Phe Asn Lys Ile Arg 
    850                 855                 860                 
Gln Leu Ala Pro Met His Asn Ile Thr Leu Phe Gly Cys Gly Ser Leu 
865                 870                 875                 880 
Tyr Thr Ser His Gln Asp Pro Leu Val His Arg Asn Pro Asp Lys Ala 
                885                 890                 895     
Met Lys Cys Arg Trp Ala Ala Ile Pro Val Lys Asp Ile Gly Asp Trp 
            900                 905                 910         
Val Leu Arg Lys Leu Ser Gln Asn Leu Arg Ala Lys Asn Arg Gly Thr 
        915                 920                 925             
Gly Glu Tyr Tyr His Gln Gly Val Lys Glu Phe Leu Ser His Tyr Glu 
    930                 935                 940                 
Leu Gln Asp Leu Glu Glu Glu Leu Leu Lys Trp Arg Ser Asp Arg Lys 
945                 950                 955                 960 
Ser Asn Ile Pro Cys Trp Val Leu Gln Asn Arg Leu Ala Glu Lys Leu 
                965                 970                 975     
Gly Asn Lys Glu Ala Val Val Tyr Ile Pro Val Arg Gly Gly Arg Ile 
            980                 985                 990         
Tyr Phe Ala Thr His Lys Val Ala  Thr Gly Ala Val Ser  Ile Val Phe 
        995                 1000                 1005             
Asp Gln  Lys Gln Val Trp Val  Cys Asn Ala Asp His  Val Ala Ala Ala 
    1010                 1015                 1020                 
Asn  Ile Ala Leu Thr Val  Lys Gly Ile Gly Glu  Gln Ser Ser Asp Glu  
1025                 1030                 1035                 1040 
Glu Asn Pro Asp Gly  Ser Arg Ile Lys Leu  Gln Leu Thr Ser 
                1045                 1050                 

<210>  8
<211>  1054
<212>  PRT
<213>  Artificial Sequence

<400>  8
Met Ser Ser Ala Ile Lys Ser Tyr Lys Ser Val Leu Arg Pro Asn Glu 
1               5                   10                  15      
Arg Lys Asn Gln Leu Leu Lys Ser Thr Ile Gln Cys Leu Glu Asp Gly 
            20                  25                  30          
Ser Ala Phe Phe Phe Lys Met Leu Gln Gly Leu Phe Gly Gly Ile Thr 
        35                  40                  45              
Pro Glu Ile Val Arg Phe Ser Thr Glu Gln Glu Lys Gln Gln Gln Asp 
    50                  55                  60                  
Ile Ala Leu Trp Cys Ala Val Asn Trp Phe Arg Pro Val Ser Gln Asp 
65                  70                  75                  80  
Ser Leu Thr His Thr Ile Ala Ser Asp Asn Leu Val Glu Lys Phe Glu 
                85                  90                  95      
Glu Tyr Tyr Gly Gly Thr Ala Ser Asp Ala Ile Lys Gln Tyr Phe Ser 
            100                 105                 110         
Ala Ser Ile Gly Glu Ser Tyr Tyr Trp Asn Asp Cys Arg Gln Gln Tyr 
        115                 120                 125             
Tyr Asp Leu Cys Arg Glu Leu Gly Val Glu Val Ser Asp Leu Thr His 
    130                 135                 140                 
Asp Leu Glu Ile Leu Cys Arg Glu Lys Cys Leu Ala Val Ala Thr Glu 
145                 150                 155                 160 
Ser Asn Gln Tyr Asn Ser Ile Ile Ser Val Leu Phe Gly Thr Gly Arg 
                165                 170                 175     
Lys Glu Asp Arg Ser Val Lys Leu Arg Ile Thr Lys Lys Ile Leu Glu 
            180                 185                 190         
Ala Ile Ser Asn Leu Lys Glu Ile Pro Lys Asn Val Ala Pro Ile Gln 
        195                 200                 205             
Glu Ile Ile Leu Asn Val Ala Lys Ala Thr Lys Glu Thr Phe Arg Gln 
    210                 215                 220                 
Val Tyr Ala Gly Asn Leu Gly Ala Pro Ser Thr Leu Glu Arg Phe Ile 
225                 230                 235                 240 
Ala Lys Asp Gly Gln Lys Glu Phe Asp Leu Lys Lys Leu Gln Thr Asp 
                245                 250                 255     
Leu Lys Lys Val Ile Arg Gly Lys Ser Lys Glu Arg Asp Trp Cys Cys 
            260                 265                 270         
Gln Glu Glu Leu Arg Ser Tyr Val Glu Gln Asn Thr Ile Gln Tyr Asp 
        275                 280                 285             
Leu Trp Ala Trp Gly Glu Met Phe Asn Lys Ala His Thr Ala Leu Lys 
    290                 295                 300                 
Ile Lys Ser Thr Arg Asn Tyr Asn Phe Ala Lys Gln Arg Leu Glu Gln 
305                 310                 315                 320 
Phe Lys Arg Ile Gln Ser Leu Asn Asn Leu Leu Val Val Lys Lys Leu 
                325                 330                 335     
Asn Asp Phe Phe Asp Ser Glu Phe Phe Ser Gly Glu Glu Thr Tyr Thr 
            340                 345                 350         
Ile Cys Val His His Leu Gly Gly Lys Arg Leu Ser Lys Leu Tyr Lys 
        355                 360                 365             
Ala Trp Glu Asp Asp Pro Ala Asp Pro Glu Asn Ala Ile Val Val Leu 
    370                 375                 380                 
Cys Asp Asp Leu Lys Asn Asn Phe Lys Lys Glu Pro Ile Arg Asn Ile 
385                 390                 395                 400 
Leu Arg Tyr Ile Phe Thr Ile Arg Gln Glu Cys Ser Ala Gln Asp Ile 
                405                 410                 415     
Leu Ala Ala Ala Lys Tyr Asn Gln Gln Leu Asp Arg Tyr Lys Ser Gln 
            420                 425                 430         
Lys Ala Asn Pro Ser Val Leu Gly Asn Gln Gly Phe Thr Trp Arg Asn 
        435                 440                 445             
Ala Val Ile Leu Pro Glu Lys Ala Gln Arg Asn Asp Arg Pro Asn Ser 
    450                 455                 460                 
Leu Asp Leu Arg Ile Trp Leu Tyr Leu Lys Leu Arg His Pro Asp Gly 
465                 470                 475                 480 
Arg Trp Lys Lys His His Ile Pro Phe Tyr Asp Thr Arg Phe Phe Gln 
                485                 490                 495     
Glu Ile Tyr Ala Ala Gly Asn Ser Pro Val Asp Thr Cys Gln Phe Arg 
            500                 505                 510         
Thr Pro Arg Phe Gly Tyr His Leu Pro Lys Leu Thr Asp Gln Thr Ala 
        515                 520                 525             
Ile Arg Val Asn Lys Lys His Val Lys Ala Ala Lys Thr Glu Ala Arg 
    530                 535                 540                 
Ile Arg Leu Ala Ile Gln Gln Gly Thr Leu Pro Val Ser Asn Leu Lys 
545                 550                 555                 560 
Ile Thr Arg Ile Ser Ala Thr Ile Asn Ser Lys Gly Gln Val Arg Ile 
                565                 570                 575     
Pro Val Lys Phe Asp Val Gly Arg Gln Lys Gly Thr Leu Gln Ile Gly 
            580                 585                 590         
Asp Arg Phe Cys Gly Tyr Asp Gln Asn Gln Thr Ala Ser His Ala Tyr 
        595                 600                 605             
Ser Leu Trp Glu Val Val Lys Glu Gly Gln Tyr His Lys Glu Leu Gly 
    610                 615                 620                 
Cys Phe Val Arg Phe Ile Ser Ser Gly Asp Ile Val Ser Ile Thr Glu 
625                 630                 635                 640 
Asn Arg Gly Asn Gln Phe Asp Gln Leu Ser Tyr Glu Gly Leu Ala Tyr 
                645                 650                 655     
Pro Gln Tyr Ala Asp Trp Arg Lys Lys Ala Ser Lys Phe Val Ser Leu 
            660                 665                 670         
Trp Gln Ile Thr Lys Lys Asn Lys Lys Lys Glu Ile Val Thr Val Glu 
        675                 680                 685             
Ala Lys Glu Lys Phe Asp Ala Ile Cys Lys Tyr Gln Pro Arg Leu Tyr 
    690                 695                 700                 
Lys Phe Asn Lys Glu Tyr Ala Tyr Leu Leu Arg Asp Ile Val Arg Gly 
705                 710                 715                 720 
Lys Ser Leu Val Glu Leu Gln Gln Ile Arg Gln Glu Ile Phe Arg Phe 
                725                 730                 735     
Ile Glu Gln Asp Cys Gly Val Thr Arg Leu Gly Ser Leu Ser Leu Ser 
            740                 745                 750         
Thr Leu Glu Thr Val Lys Ala Val Lys Gly Ile Ile Tyr Ser Tyr Phe 
        755                 760                 765             
Ser Thr Ala Leu Asn Ala Ser Lys Asn Asn Pro Ile Ser Asp Glu Gln 
    770                 775                 780                 
Arg Lys Glu Phe Asp Pro Glu Leu Phe Ala Leu Leu Glu Lys Leu Glu 
785                 790                 795                 800 
Leu Ile Arg Thr Arg Lys Lys Lys Gln Lys Val Glu Arg Ile Ala Asn 
                805                 810                 815     
Ser Leu Ile Gln Thr Cys Leu Glu Asn Asn Ile Lys Phe Ile Arg Gly 
            820                 825                 830         
Glu Gly Asp Leu Ser Thr Thr Asn Asn Ala Thr Lys Lys Lys Ala Asn 
        835                 840                 845             
Ser Arg Ser Met Asp Trp Leu Ala Arg Gly Val Phe Asn Lys Ile Arg 
    850                 855                 860                 
Gln Leu Ala Pro Met His Asn Ile Thr Leu Phe Gly Cys Gly Ser Leu 
865                 870                 875                 880 
Tyr Thr Ser His Gln Asp Pro Leu Val His Arg Asn Pro Asp Lys Ala 
                885                 890                 895     
Met Lys Cys Arg Trp Ala Ala Ile Pro Val Lys Asp Ile Gly Asp Trp 
            900                 905                 910         
Val Leu Arg Lys Leu Ser Gln Asn Leu Arg Ala Lys Asn Ile Gly Thr 
        915                 920                 925             
Gly Glu Tyr Tyr His Gln Gly Val Lys Glu Phe Leu Ser His Tyr Glu 
    930                 935                 940                 
Leu Gln Asp Leu Glu Glu Glu Leu Leu Lys Trp Arg Ser Asp Arg Lys 
945                 950                 955                 960 
Ser Asn Ile Pro Cys Trp Val Leu Gln Asn Arg Leu Ala Glu Lys Leu 
                965                 970                 975     
Gly Asn Lys Glu Ala Val Val Tyr Ile Pro Val Arg Gly Gly Arg Ile 
            980                 985                 990         
Tyr Phe Ala Thr His Lys Val Ala  Thr Gly Ala Val Ser  Ile Val Phe 
        995                 1000                 1005             
Asp Gln  Lys Gln Val Trp Val  Cys Asn Ala Asp His  Val Ala Ala Ala 
    1010                 1015                 1020                 
Asn  Ile Ala Leu Thr Val  Lys Gly Ile Gly Glu  Gln Ser Ser Asp Glu  
1025                 1030                 1035                 1040 
Glu Asn Pro Asp Gly  Ser Arg Ile Lys Leu  Gln Leu Thr Ser 
                1045                 1050                 

<210>  9
<211>  1054
<212>  PRT
<213>  Artificial Sequence

<400>  9
Met Ser Ser Ala Ile Lys Ser Tyr Lys Ser Val Leu Arg Pro Asn Glu 
1               5                   10                  15      
Arg Lys Asn Gln Leu Leu Lys Ser Thr Ile Gln Cys Leu Glu Asp Gly 
            20                  25                  30          
Ser Ala Phe Phe Phe Lys Met Leu Gln Gly Leu Phe Gly Gly Ile Thr 
        35                  40                  45              
Pro Glu Ile Val Arg Phe Ser Thr Glu Gln Glu Lys Gln Gln Gln Asp 
    50                  55                  60                  
Ile Ala Leu Trp Cys Ala Val Asn Trp Phe Arg Pro Val Ser Gln Asp 
65                  70                  75                  80  
Ser Leu Thr His Thr Ile Ala Ser Asp Asn Leu Val Glu Lys Phe Glu 
                85                  90                  95      
Glu Tyr Tyr Gly Gly Thr Ala Ser Asp Ala Ile Lys Gln Tyr Phe Ser 
            100                 105                 110         
Ala Ser Ile Gly Glu Ser Tyr Tyr Trp Asn Asp Cys Arg Gln Gln Tyr 
        115                 120                 125             
Tyr Asp Leu Cys Arg Glu Leu Gly Val Glu Val Ser Asp Leu Thr His 
    130                 135                 140                 
Asp Leu Glu Ile Leu Cys Arg Glu Lys Cys Leu Ala Val Ala Thr Glu 
145                 150                 155                 160 
Ser Asn Gln Tyr Asn Ser Ile Ile Ser Val Leu Phe Gly Thr Gly Arg 
                165                 170                 175     
Lys Glu Asp Arg Ser Val Lys Leu Arg Ile Thr Lys Lys Ile Leu Glu 
            180                 185                 190         
Ala Ile Ser Asn Leu Lys Glu Ile Pro Lys Asn Val Ala Pro Ile Gln 
        195                 200                 205             
Glu Ile Ile Leu Asn Val Ala Lys Ala Thr Lys Glu Thr Phe Arg Gln 
    210                 215                 220                 
Val Tyr Ala Gly Asn Leu Gly Ala Pro Ser Thr Leu Glu Arg Phe Ile 
225                 230                 235                 240 
Ala Lys Asp Gly Gln Lys Glu Phe Asp Leu Lys Lys Leu Gln Thr Asp 
                245                 250                 255     
Leu Lys Lys Val Ile Arg Gly Lys Ser Lys Glu Arg Asp Trp Cys Cys 
            260                 265                 270         
Gln Glu Glu Leu Arg Ser Tyr Val Glu Gln Asn Thr Ile Gln Tyr Asp 
        275                 280                 285             
Leu Trp Ala Trp Gly Glu Met Phe Asn Lys Ala His Thr Ala Leu Lys 
    290                 295                 300                 
Ile Lys Ser Thr Arg Asn Tyr Asn Phe Ala Lys Gln Arg Leu Glu Gln 
305                 310                 315                 320 
Phe Lys Arg Ile Gln Ser Leu Asn Asn Leu Leu Val Val Lys Lys Leu 
                325                 330                 335     
Asn Asp Phe Phe Asp Ser Glu Phe Phe Ser Gly Glu Glu Thr Tyr Thr 
            340                 345                 350         
Ile Cys Val His His Leu Gly Gly Lys Arg Leu Ser Lys Leu Tyr Lys 
        355                 360                 365             
Ala Trp Glu Asp Asp Pro Ala Asp Pro Glu Asn Ala Ile Val Val Leu 
    370                 375                 380                 
Cys Asp Asp Leu Lys Asn Asn Phe Lys Lys Glu Pro Ile Arg Asn Ile 
385                 390                 395                 400 
Leu Arg Tyr Ile Phe Thr Ile Arg Gln Glu Cys Ser Ala Gln Asp Ile 
                405                 410                 415     
Leu Ala Ala Ala Lys Tyr Asn Gln Gln Leu Asp Arg Tyr Lys Ser Gln 
            420                 425                 430         
Lys Ala Asn Pro Ser Val Leu Gly Asn Gln Gly Phe Thr Trp Arg Asn 
        435                 440                 445             
Ala Val Ile Leu Pro Glu Lys Ala Gln Arg Asn Asp Arg Pro Asn Ser 
    450                 455                 460                 
Leu Asp Leu Arg Ile Trp Leu Tyr Leu Lys Leu Arg His Pro Asp Gly 
465                 470                 475                 480 
Arg Trp Lys Lys His His Ile Pro Phe Tyr Asp Thr Arg Phe Phe Gln 
                485                 490                 495     
Glu Ile Tyr Ala Ala Gly Asn Ser Pro Val Asp Thr Cys Gln Phe Arg 
            500                 505                 510         
Thr Pro Arg Phe Gly Tyr His Leu Pro Lys Leu Thr Asp Gln Thr Ala 
        515                 520                 525             
Ile Arg Val Asn Lys Lys His Val Lys Ala Ala Lys Thr Glu Ala Arg 
    530                 535                 540                 
Ile Arg Leu Ala Ile Gln Gln Gly Thr Leu Pro Val Ser Asn Leu Lys 
545                 550                 555                 560 
Ile Thr Arg Ile Ser Ala Thr Ile Asn Ser Lys Gly Gln Val Arg Ile 
                565                 570                 575     
Pro Val Lys Phe Asp Val Gly Arg Gln Lys Gly Thr Leu Gln Ile Gly 
            580                 585                 590         
Asp Arg Phe Cys Gly Tyr Asp Gln Asn Gln Thr Ala Ser His Ala Tyr 
        595                 600                 605             
Ser Leu Trp Glu Val Val Lys Glu Gly Gln Tyr His Lys Glu Leu Gly 
    610                 615                 620                 
Cys Phe Val Arg Phe Ile Ser Ser Gly Asp Ile Val Ser Ile Thr Glu 
625                 630                 635                 640 
Asn Arg Gly Asn Gln Phe Asp Gln Leu Ser Tyr Glu Gly Leu Ala Tyr 
                645                 650                 655     
Pro Gln Tyr Ala Asp Trp Arg Lys Lys Ala Ser Lys Phe Val Ser Leu 
            660                 665                 670         
Trp Gln Ile Thr Lys Lys Asn Lys Lys Lys Glu Ile Val Thr Val Glu 
        675                 680                 685             
Ala Lys Glu Lys Phe Asp Ala Ile Cys Lys Tyr Gln Pro Arg Leu Tyr 
    690                 695                 700                 
Lys Phe Asn Lys Glu Tyr Ala Tyr Leu Leu Arg Asp Ile Val Arg Gly 
705                 710                 715                 720 
Lys Ser Leu Val Glu Leu Gln Gln Ile Arg Gln Glu Ile Phe Arg Phe 
                725                 730                 735     
Ile Glu Gln Asp Cys Gly Val Thr Arg Leu Gly Ser Leu Ser Leu Ser 
            740                 745                 750         
Thr Leu Glu Thr Val Lys Ala Val Lys Gly Ile Ile Tyr Ser Tyr Phe 
        755                 760                 765             
Ser Thr Ala Leu Asn Ala Ser Lys Asn Asn Pro Ile Ser Asp Glu Gln 
    770                 775                 780                 
Arg Lys Glu Phe Asp Pro Glu Leu Phe Ala Leu Leu Glu Lys Leu Glu 
785                 790                 795                 800 
Leu Ile Arg Thr Arg Lys Lys Lys Gln Lys Val Glu Arg Ile Ala Asn 
                805                 810                 815     
Ser Leu Ile Gln Thr Cys Leu Glu Asn Asn Ile Lys Phe Ile Arg Gly 
            820                 825                 830         
Glu Gly Asp Leu Ser Thr Thr Asn Asn Ala Thr Lys Lys Lys Ala Asn 
        835                 840                 845             
Ser Arg Ser Met Asp Trp Leu Ala Arg Gly Val Phe Asn Lys Ile Arg 
    850                 855                 860                 
Gln Leu Ala Pro Met His Asn Ile Thr Leu Phe Gly Cys Gly Ser Leu 
865                 870                 875                 880 
Tyr Thr Ser His Gln Asp Pro Leu Val His Arg Asn Pro Asp Lys Ala 
                885                 890                 895     
Met Lys Cys Arg Trp Ala Ala Ile Pro Val Lys Asp Ile Gly Asp Trp 
            900                 905                 910         
Val Leu Arg Lys Leu Ser Gln Asn Leu Arg Ala Lys Asn Arg Gly Thr 
        915                 920                 925             
Gly Glu Tyr Tyr His Gln Gly Val Lys Glu Phe Leu Ser His Tyr Glu 
    930                 935                 940                 
Leu Gln Asp Leu Glu Glu Glu Leu Leu Lys Trp Arg Ser Asp Arg Lys 
945                 950                 955                 960 
Ser Asn Ile Pro Cys Trp Val Leu Gln Asn Arg Leu Ala Glu Lys Leu 
                965                 970                 975     
Gly Asn Lys Glu Ala Val Val Tyr Ile Pro Val Arg Gly Gly Arg Ile 
            980                 985                 990         
Tyr Phe Ala Thr His Lys Val Ala  Thr Gly Ala Val Ser  Ile Val Phe 
        995                 1000                 1005             
Asp Gln  Lys Gln Val Trp Val  Cys Asn Ala Asp His  Val Ala Ala Ala 
    1010                 1015                 1020                 
Asn  Ile Ala Leu Thr Val  Lys Gly Ile Gly Glu  Gln Ser Ser Asp Glu  
1025                 1030                 1035                 1040 
Glu Asn Pro Asp Gly  Ser Arg Ile Lys Leu  Gln Leu Thr Ser 
                1045                 1050                 

<210>  10
<211>  1054
<212>  PRT
<213>  Artificial Sequence

<400>  10
Met Ser Ser Ala Ile Lys Ser Tyr Lys Ser Val Leu Arg Pro Asn Glu 
1               5                   10                  15      
Arg Lys Asn Gln Leu Leu Lys Ser Thr Ile Gln Cys Leu Glu Asp Gly 
            20                  25                  30          
Ser Ala Phe Phe Phe Lys Met Leu Gln Gly Leu Phe Gly Gly Ile Thr 
        35                  40                  45              
Pro Glu Ile Val Arg Phe Ser Thr Glu Gln Glu Lys Gln Gln Gln Asp 
    50                  55                  60                  
Ile Ala Leu Trp Cys Ala Val Asn Trp Phe Arg Pro Val Ser Gln Asp 
65                  70                  75                  80  
Ser Leu Thr His Thr Ile Ala Ser Asp Asn Leu Val Glu Lys Phe Glu 
                85                  90                  95      
Glu Tyr Tyr Gly Gly Thr Ala Ser Asp Ala Ile Lys Gln Tyr Phe Ser 
            100                 105                 110         
Ala Ser Ile Gly Glu Ser Tyr Tyr Trp Asn Asp Cys Arg Gln Gln Tyr 
        115                 120                 125             
Tyr Asp Leu Cys Arg Glu Leu Gly Val Glu Val Ser Asp Leu Thr His 
    130                 135                 140                 
Asp Leu Glu Ile Leu Cys Arg Glu Lys Cys Leu Ala Val Ala Thr Glu 
145                 150                 155                 160 
Ser Asn Gln Tyr Asn Ser Ile Ile Ser Val Leu Phe Gly Thr Gly Arg 
                165                 170                 175     
Lys Glu Asp Arg Ser Val Lys Leu Arg Ile Thr Lys Lys Ile Leu Glu 
            180                 185                 190         
Ala Ile Ser Asn Leu Lys Glu Ile Pro Lys Asn Val Ala Pro Ile Gln 
        195                 200                 205             
Glu Ile Ile Leu Asn Val Ala Lys Ala Thr Lys Glu Thr Phe Arg Gln 
    210                 215                 220                 
Val Tyr Ala Gly Asn Leu Gly Ala Pro Ser Thr Leu Glu Arg Phe Ile 
225                 230                 235                 240 
Ala Lys Asp Gly Gln Lys Glu Phe Asp Leu Lys Lys Leu Gln Thr Asp 
                245                 250                 255     
Leu Lys Lys Val Ile Arg Gly Lys Ser Lys Glu Arg Asp Trp Cys Cys 
            260                 265                 270         
Gln Glu Glu Leu Arg Ser Tyr Val Glu Gln Asn Thr Ile Gln Tyr Asp 
        275                 280                 285             
Leu Trp Ala Trp Gly Glu Met Phe Asn Lys Ala His Thr Ala Leu Lys 
    290                 295                 300                 
Ile Lys Ser Thr Arg Asn Tyr Asn Phe Ala Lys Gln Arg Leu Glu Gln 
305                 310                 315                 320 
Phe Lys Arg Ile Gln Ser Leu Asn Asn Leu Leu Val Val Lys Lys Leu 
                325                 330                 335     
Asn Asp Phe Phe Asp Ser Glu Phe Phe Ser Gly Glu Glu Thr Tyr Thr 
            340                 345                 350         
Ile Cys Val His His Leu Gly Gly Lys Arg Leu Ser Lys Leu Tyr Lys 
        355                 360                 365             
Ala Trp Glu Asp Asp Pro Ala Asp Pro Glu Asn Ala Ile Val Val Leu 
    370                 375                 380                 
Cys Asp Asp Leu Lys Asn Asn Phe Lys Lys Glu Pro Ile Arg Asn Ile 
385                 390                 395                 400 
Leu Arg Tyr Ile Phe Thr Ile Arg Gln Glu Cys Ser Ala Gln Asp Ile 
                405                 410                 415     
Leu Ala Ala Ala Lys Tyr Asn Gln Gln Leu Asp Arg Tyr Lys Ser Gln 
            420                 425                 430         
Lys Ala Asn Pro Ser Val Leu Gly Asn Gln Gly Phe Thr Trp Arg Asn 
        435                 440                 445             
Ala Val Ile Leu Pro Glu Lys Ala Gln Arg Asn Asp Arg Pro Asn Ser 
    450                 455                 460                 
Leu Asp Leu Arg Ile Trp Leu Tyr Leu Lys Leu Arg His Pro Asp Gly 
465                 470                 475                 480 
Arg Trp Lys Lys His His Ile Pro Phe Tyr Asp Thr Arg Phe Phe Gln 
                485                 490                 495     
Glu Ile Tyr Ala Ala Gly Asn Ser Pro Val Asp Thr Cys Gln Phe Arg 
            500                 505                 510         
Thr Pro Arg Phe Gly Tyr His Leu Pro Lys Leu Thr Asp Gln Thr Ala 
        515                 520                 525             
Ile Arg Val Asn Lys Lys His Val Lys Ala Ala Lys Thr Glu Ala Arg 
    530                 535                 540                 
Ile Arg Leu Ala Ile Gln Gln Gly Thr Leu Pro Val Ser Asn Leu Lys 
545                 550                 555                 560 
Ile Thr Arg Ile Ser Ala Thr Ile Asn Ser Lys Gly Gln Val Arg Ile 
                565                 570                 575     
Pro Val Lys Phe Asp Val Gly Arg Gln Lys Gly Thr Leu Gln Ile Gly 
            580                 585                 590         
Asp Arg Phe Cys Gly Tyr Asp Gln Asn Gln Thr Ala Ser His Ala Tyr 
        595                 600                 605             
Ser Leu Trp Glu Val Val Lys Glu Gly Gln Tyr His Lys Glu Leu Gly 
    610                 615                 620                 
Cys Phe Val Arg Phe Ile Ser Ser Gly Asp Ile Val Ser Ile Thr Glu 
625                 630                 635                 640 
Asn Arg Gly Asn Gln Phe Asp Gln Leu Ser Tyr Glu Gly Leu Ala Tyr 
                645                 650                 655     
Pro Gln Tyr Ala Asp Trp Arg Lys Lys Ala Ser Lys Phe Val Ser Leu 
            660                 665                 670         
Trp Gln Ile Thr Lys Lys Asn Lys Lys Lys Glu Ile Val Thr Val Glu 
        675                 680                 685             
Ala Lys Glu Lys Phe Asp Ala Ile Cys Lys Tyr Gln Pro Arg Leu Tyr 
    690                 695                 700                 
Lys Phe Asn Lys Glu Tyr Ala Tyr Leu Leu Arg Asp Ile Val Arg Gly 
705                 710                 715                 720 
Lys Ser Leu Val Glu Leu Gln Gln Ile Arg Gln Glu Ile Phe Arg Phe 
                725                 730                 735     
Ile Glu Gln Asp Cys Gly Val Thr Arg Leu Gly Ser Leu Ser Leu Ser 
            740                 745                 750         
Thr Leu Glu Thr Val Lys Ala Val Lys Gly Ile Ile Tyr Ser Tyr Phe 
        755                 760                 765             
Ser Thr Ala Leu Asn Ala Ser Lys Asn Asn Pro Ile Ser Asp Glu Gln 
    770                 775                 780                 
Arg Lys Glu Phe Asp Pro Glu Leu Phe Ala Leu Leu Glu Lys Leu Glu 
785                 790                 795                 800 
Leu Ile Arg Thr Arg Lys Lys Lys Gln Lys Val Glu Arg Ile Ala Asn 
                805                 810                 815     
Ser Leu Ile Gln Thr Cys Leu Glu Asn Asn Ile Lys Phe Ile Arg Gly 
            820                 825                 830         
Glu Gly Asp Leu Ser Thr Thr Asn Asn Ala Thr Lys Lys Lys Ala Asn 
        835                 840                 845             
Ser Arg Ser Met Asp Trp Leu Ala Arg Gly Val Phe Asn Lys Ile Arg 
    850                 855                 860                 
Gln Leu Ala Pro Met His Asn Ile Thr Leu Phe Gly Cys Gly Ser Leu 
865                 870                 875                 880 
Tyr Thr Ser His Gln Asp Pro Leu Val His Arg Asn Pro Asp Lys Ala 
                885                 890                 895     
Met Lys Cys Arg Trp Ala Ala Ile Pro Val Lys Asp Ile Gly Asp Trp 
            900                 905                 910         
Val Leu Arg Lys Leu Ser Gln Asn Leu Arg Ala Lys Asn Gly Gly Thr 
        915                 920                 925             
Gly Glu Tyr Tyr His Gln Gly Val Lys Glu Phe Leu Ser His Tyr Glu 
    930                 935                 940                 
Leu Gln Asp Leu Glu Glu Glu Leu Leu Lys Trp Arg Ser Asp Arg Lys 
945                 950                 955                 960 
Ser Asn Ile Pro Cys Trp Val Leu Gln Asn Arg Leu Ala Glu Lys Leu 
                965                 970                 975     
Gly Asn Lys Glu Ala Val Val Tyr Ile Pro Val Arg Gly Gly Arg Ile 
            980                 985                 990         
Tyr Phe Ala Thr His Lys Val Ala  Thr Gly Ala Val Ser  Ile Val Phe 
        995                 1000                 1005             
Asp Gln  Lys Gln Val Trp Val  Cys Asn Ala Asp His  Val Ala Ala Ala 
    1010                 1015                 1020                 
Asn  Ile Ala Leu Thr Val  Lys Gly Ile Gly Glu  Gln Ser Ser Asp Glu  
1025                 1030                 1035                 1040 
Glu Asn Pro Asp Gly  Ser Arg Ile Lys Leu  Gln Leu Thr Ser 
                1045                 1050                 

<210>  11
<211>  1056
<212>  PRT
<213>  Artificial Sequence

<400>  11
Met Ser Ser Ala Ile Lys Ser Tyr Lys Ser Val Leu Arg Pro Asn Glu 
1               5                   10                  15      
Arg Lys Asn Gln Leu Leu Lys Ser Thr Ile Gln Cys Leu Glu Asp Gly 
            20                  25                  30          
Ser Ala Phe Phe Phe Lys Met Leu Gln Gly Leu Phe Gly Gly Ile Thr 
        35                  40                  45              
Pro Glu Ile Val Arg Phe Ser Thr Glu Gln Glu Lys Gln Gln Gln Asp 
    50                  55                  60                  
Ile Ala Leu Trp Cys Ala Val Asn Trp Phe Arg Pro Val Ser Gln Asp 
65                  70                  75                  80  
Ser Leu Thr His Thr Ile Ala Ser Asp Asn Leu Val Glu Lys Phe Glu 
                85                  90                  95      
Glu Tyr Tyr Gly Gly Thr Ala Ser Asp Ala Ile Lys Gln Tyr Phe Ser 
            100                 105                 110         
Ala Ser Ile Gly Glu Ser Tyr Tyr Trp Asn Asp Cys Arg Gln Gln Tyr 
        115                 120                 125             
Tyr Asp Leu Cys Arg Glu Leu Gly Val Glu Val Ser Asp Leu Thr His 
    130                 135                 140                 
Asp Leu Glu Ile Leu Cys Arg Glu Lys Cys Leu Ala Val Ala Thr Glu 
145                 150                 155                 160 
Ser Asn Gln Tyr Asn Ser Ile Ile Ser Val Leu Phe Gly Thr Gly Arg 
                165                 170                 175     
Lys Glu Asp Arg Ser Val Lys Leu Arg Ile Thr Lys Lys Ile Leu Glu 
            180                 185                 190         
Ala Ile Ser Asn Leu Lys Glu Ile Pro Lys Asn Val Ala Pro Ile Gln 
        195                 200                 205             
Glu Ile Ile Leu Asn Val Ala Lys Ala Thr Lys Glu Thr Phe Arg Gln 
    210                 215                 220                 
Val Tyr Ala Gly Asn Leu Gly Ala Pro Ser Thr Leu Glu Arg Phe Ile 
225                 230                 235                 240 
Ala Lys Asp Gly Gln Lys Glu Phe Asp Leu Lys Lys Leu Gln Thr Asp 
                245                 250                 255     
Leu Lys Lys Val Ile Arg Gly Lys Ser Lys Glu Arg Asp Trp Cys Cys 
            260                 265                 270         
Gln Glu Glu Leu Arg Ser Tyr Val Glu Gln Asn Thr Ile Gln Tyr Asp 
        275                 280                 285             
Leu Trp Ala Trp Gly Glu Met Phe Asn Lys Ala His Thr Ala Leu Lys 
    290                 295                 300                 
Ile Lys Ser Thr Arg Asn Tyr Asn Phe Ala Lys Gln Arg Leu Glu Gln 
305                 310                 315                 320 
Phe Lys Arg Ile Gln Ser Leu Asn Asn Leu Leu Val Val Lys Lys Leu 
                325                 330                 335     
Asn Asp Phe Phe Asp Ser Glu Phe Phe Ser Gly Glu Glu Thr Tyr Thr 
            340                 345                 350         
Ile Cys Val His His Leu Gly Gly Lys Arg Leu Ser Lys Leu Tyr Lys 
        355                 360                 365             
Ala Trp Glu Asp Asp Pro Ala Asp Pro Glu Asn Ala Ile Val Val Leu 
    370                 375                 380                 
Cys Asp Asp Leu Lys Asn Asn Phe Lys Lys Glu Pro Ile Arg Asn Ile 
385                 390                 395                 400 
Leu Arg Tyr Ile Phe Thr Ile Arg Gln Glu Cys Ser Ala Gln Asp Ile 
                405                 410                 415     
Leu Ala Ala Ala Lys Tyr Asn Gln Gln Leu Asp Arg Tyr Lys Ser Gln 
            420                 425                 430         
Lys Ala Asn Pro Ser Val Leu Gly Gly Gly Asn Gln Gly Phe Thr Trp 
        435                 440                 445             
Arg Asn Ala Val Ile Leu Pro Glu Lys Ala Gln Arg Asn Asp Arg Pro 
    450                 455                 460                 
Asn Ser Leu Asp Leu Arg Ile Trp Leu Tyr Leu Lys Leu Arg His Pro 
465                 470                 475                 480 
Asp Gly Arg Trp Lys Lys His His Ile Pro Phe Tyr Asp Thr Arg Phe 
                485                 490                 495     
Phe Gln Glu Ile Tyr Ala Ala Gly Asn Ser Pro Val Asp Thr Cys Gln 
            500                 505                 510         
Phe Arg Thr Pro Arg Phe Gly Tyr His Leu Pro Lys Leu Thr Asp Gln 
        515                 520                 525             
Thr Ala Ile Arg Val Asn Lys Lys His Val Lys Ala Ala Lys Thr Glu 
    530                 535                 540                 
Ala Arg Ile Arg Leu Ala Ile Gln Gln Gly Thr Leu Pro Val Ser Asn 
545                 550                 555                 560 
Leu Lys Ile Thr Arg Ile Ser Ala Thr Ile Asn Ser Lys Gly Gln Val 
                565                 570                 575     
Arg Ile Pro Val Lys Phe Asp Val Gly Arg Gln Lys Gly Thr Leu Gln 
            580                 585                 590         
Ile Gly Asp Arg Phe Cys Gly Tyr Asp Gln Asn Gln Thr Ala Ser His 
        595                 600                 605             
Ala Tyr Ser Leu Trp Glu Val Val Lys Glu Gly Gln Tyr His Lys Glu 
    610                 615                 620                 
Leu Gly Cys Phe Val Arg Phe Ile Ser Ser Gly Asp Ile Val Ser Ile 
625                 630                 635                 640 
Thr Glu Asn Arg Gly Asn Gln Phe Asp Gln Leu Ser Tyr Glu Gly Leu 
                645                 650                 655     
Ala Tyr Pro Gln Tyr Ala Asp Trp Arg Lys Lys Ala Ser Lys Phe Val 
            660                 665                 670         
Ser Leu Trp Gln Ile Thr Lys Lys Asn Lys Lys Lys Glu Ile Val Thr 
        675                 680                 685             
Val Glu Ala Lys Glu Lys Phe Asp Ala Ile Cys Lys Tyr Gln Pro Arg 
    690                 695                 700                 
Leu Tyr Lys Phe Asn Lys Glu Tyr Ala Tyr Leu Leu Arg Asp Ile Val 
705                 710                 715                 720 
Arg Gly Lys Ser Leu Val Glu Leu Gln Gln Ile Arg Gln Glu Ile Phe 
                725                 730                 735     
Arg Phe Ile Glu Gln Asp Cys Gly Val Thr Arg Leu Gly Ser Leu Ser 
            740                 745                 750         
Leu Ser Thr Leu Glu Thr Val Lys Ala Val Lys Gly Ile Ile Tyr Ser 
        755                 760                 765             
Tyr Phe Ser Thr Ala Leu Asn Ala Ser Lys Asn Asn Pro Ile Ser Asp 
    770                 775                 780                 
Glu Gln Arg Lys Glu Phe Asp Pro Glu Leu Phe Ala Leu Leu Glu Lys 
785                 790                 795                 800 
Leu Glu Leu Ile Arg Thr Arg Lys Lys Lys Gln Lys Val Glu Arg Ile 
                805                 810                 815     
Ala Asn Ser Leu Ile Gln Thr Cys Leu Glu Asn Asn Ile Lys Phe Ile 
            820                 825                 830         
Arg Gly Glu Gly Asp Leu Ser Thr Thr Asn Asn Ala Thr Lys Lys Lys 
        835                 840                 845             
Ala Asn Ser Arg Ser Met Asp Trp Leu Ala Arg Gly Val Phe Asn Lys 
    850                 855                 860                 
Ile Arg Gln Leu Ala Pro Met His Asn Ile Thr Leu Phe Gly Cys Gly 
865                 870                 875                 880 
Ser Leu Tyr Thr Ser His Gln Asp Pro Leu Val His Arg Asn Pro Asp 
                885                 890                 895     
Lys Ala Met Lys Cys Arg Trp Ala Ala Ile Pro Val Lys Asp Ile Gly 
            900                 905                 910         
Asp Trp Val Leu Arg Lys Leu Ser Gln Asn Leu Arg Ala Lys Asn Gly 
        915                 920                 925             
Gly Thr Gly Glu Tyr Tyr His Gln Gly Val Lys Glu Phe Leu Ser His 
    930                 935                 940                 
Tyr Glu Leu Gln Asp Leu Glu Glu Glu Leu Leu Lys Trp Arg Ser Asp 
945                 950                 955                 960 
Arg Lys Ser Asn Ile Pro Cys Trp Val Leu Gln Asn Arg Leu Ala Glu 
                965                 970                 975     
Lys Leu Gly Asn Lys Glu Ala Val Val Tyr Ile Pro Val Arg Gly Gly 
            980                 985                 990         
Arg Ile Tyr Phe Ala Thr His Lys  Val Ala Thr Gly Ala  Val Ser Ile 
        995                 1000                 1005             
Val Phe  Asp Gln Lys Gln Val  Trp Val Cys Asn Ala  Asp His Val Ala 
    1010                 1015                 1020                 
Ala  Ala Asn Ile Ala Leu  Thr Val Lys Gly Ile  Gly Glu Gln Ser Ser  
1025                 1030                 1035                 1040 
Asp Glu Glu Asn Pro  Asp Gly Ser Arg Ile  Lys Leu Gln Leu Thr  Ser 
                1045                 1050                 1055     

<210>  12
<211>  1055
<212>  PRT
<213>  Artificial Sequence

<400>  12
Met Ser Ser Ala Ile Lys Ser Tyr Lys Ser Val Leu Arg Pro Asn Glu 
1               5                   10                  15      
Arg Lys Asn Gln Leu Leu Lys Ser Thr Ile Gln Cys Leu Glu Asp Gly 
            20                  25                  30          
Ser Ala Phe Phe Phe Lys Met Leu Gln Gly Leu Phe Gly Gly Ile Thr 
        35                  40                  45              
Pro Glu Ile Val Arg Phe Ser Thr Glu Gln Glu Lys Gln Gln Gln Asp 
    50                  55                  60                  
Ile Ala Leu Trp Cys Ala Val Asn Trp Phe Arg Pro Val Ser Gln Asp 
65                  70                  75                  80  
Ser Leu Thr His Thr Ile Ala Ser Asp Asn Leu Val Glu Lys Phe Glu 
                85                  90                  95      
Glu Tyr Tyr Gly Gly Thr Ala Ser Asp Ala Ile Lys Gln Tyr Phe Ser 
            100                 105                 110         
Ala Ser Ile Gly Glu Ser Tyr Tyr Trp Asn Asp Cys Arg Gln Gln Tyr 
        115                 120                 125             
Tyr Asp Leu Cys Arg Glu Leu Gly Val Glu Val Ser Asp Leu Thr His 
    130                 135                 140                 
Asp Leu Glu Ile Leu Cys Arg Glu Lys Cys Leu Ala Val Ala Thr Glu 
145                 150                 155                 160 
Ser Asn Gln Tyr Asn Ser Ile Ile Ser Val Leu Phe Gly Thr Gly Arg 
                165                 170                 175     
Lys Glu Asp Arg Ser Val Lys Leu Arg Ile Thr Lys Lys Ile Leu Glu 
            180                 185                 190         
Ala Ile Ser Asn Leu Lys Glu Ile Pro Lys Asn Val Ala Pro Ile Gln 
        195                 200                 205             
Glu Ile Ile Leu Asn Val Ala Lys Ala Thr Lys Glu Thr Phe Arg Gln 
    210                 215                 220                 
Val Tyr Ala Gly Asn Leu Gly Ala Pro Ser Thr Leu Glu Arg Phe Ile 
225                 230                 235                 240 
Ala Lys Asp Gly Gln Lys Glu Phe Asp Leu Lys Lys Leu Gln Thr Asp 
                245                 250                 255     
Leu Lys Lys Val Ile Arg Gly Lys Ser Lys Glu Arg Asp Trp Cys Cys 
            260                 265                 270         
Gln Glu Glu Leu Arg Ser Tyr Val Glu Gln Asn Thr Ile Gln Tyr Asp 
        275                 280                 285             
Leu Trp Ala Trp Gly Glu Met Phe Asn Lys Ala His Thr Ala Leu Lys 
    290                 295                 300                 
Ile Lys Ser Thr Arg Asn Tyr Asn Phe Ala Lys Gln Arg Leu Glu Gln 
305                 310                 315                 320 
Phe Lys Arg Ile Gln Ser Leu Asn Asn Leu Leu Val Val Lys Lys Leu 
                325                 330                 335     
Asn Asp Phe Phe Asp Ser Glu Phe Phe Ser Gly Glu Glu Thr Tyr Thr 
            340                 345                 350         
Ile Cys Val His His Leu Gly Gly Lys Arg Leu Ser Lys Leu Tyr Lys 
        355                 360                 365             
Ala Trp Glu Asp Asp Pro Ala Asp Pro Glu Asn Ala Ile Val Val Leu 
    370                 375                 380                 
Cys Asp Asp Leu Lys Asn Asn Phe Lys Lys Glu Pro Ile Arg Asn Ile 
385                 390                 395                 400 
Leu Arg Tyr Ile Phe Thr Ile Arg Gln Glu Cys Ser Ala Gln Asp Ile 
                405                 410                 415     
Leu Ala Ala Ala Lys Tyr Asn Gln Gln Leu Asp Arg Tyr Lys Ser Gln 
            420                 425                 430         
Lys Ala Asn Pro Ser Val Leu Gly Gly Asn Gln Gly Phe Thr Trp Arg 
        435                 440                 445             
Asn Ala Val Ile Leu Pro Glu Lys Ala Gln Arg Asn Asp Arg Pro Asn 
    450                 455                 460                 
Ser Leu Asp Leu Arg Ile Trp Leu Tyr Leu Lys Leu Arg His Pro Asp 
465                 470                 475                 480 
Gly Arg Trp Lys Lys His His Ile Pro Phe Tyr Asp Thr Arg Phe Phe 
                485                 490                 495     
Gln Glu Ile Tyr Ala Ala Gly Asn Ser Pro Val Asp Thr Cys Gln Phe 
            500                 505                 510         
Arg Thr Pro Arg Phe Gly Tyr His Leu Pro Lys Leu Thr Asp Gln Thr 
        515                 520                 525             
Ala Ile Arg Val Asn Lys Lys His Val Lys Ala Ala Lys Thr Glu Ala 
    530                 535                 540                 
Arg Ile Arg Leu Ala Ile Gln Gln Gly Thr Leu Pro Val Ser Asn Leu 
545                 550                 555                 560 
Lys Ile Thr Arg Ile Ser Ala Thr Ile Asn Ser Lys Gly Gln Val Arg 
                565                 570                 575     
Ile Pro Val Lys Phe Asp Val Gly Arg Gln Lys Gly Thr Leu Gln Ile 
            580                 585                 590         
Gly Asp Arg Phe Cys Gly Tyr Asp Gln Asn Gln Thr Ala Ser His Ala 
        595                 600                 605             
Tyr Ser Leu Trp Glu Val Val Lys Glu Gly Gln Tyr His Lys Glu Leu 
    610                 615                 620                 
Gly Cys Phe Val Arg Phe Ile Ser Ser Gly Asp Ile Val Ser Ile Thr 
625                 630                 635                 640 
Glu Asn Arg Gly Asn Gln Phe Asp Gln Leu Ser Tyr Glu Gly Leu Ala 
                645                 650                 655     
Tyr Pro Gln Tyr Ala Asp Trp Arg Lys Lys Ala Ser Lys Phe Val Ser 
            660                 665                 670         
Leu Trp Gln Ile Thr Lys Lys Asn Lys Lys Lys Glu Ile Val Thr Val 
        675                 680                 685             
Glu Ala Lys Glu Lys Phe Asp Ala Ile Cys Lys Tyr Gln Pro Arg Leu 
    690                 695                 700                 
Tyr Lys Phe Asn Lys Glu Tyr Ala Tyr Leu Leu Arg Asp Ile Val Arg 
705                 710                 715                 720 
Gly Lys Ser Leu Val Glu Leu Gln Gln Ile Arg Gln Glu Ile Phe Arg 
                725                 730                 735     
Phe Ile Glu Gln Asp Cys Gly Val Thr Arg Leu Gly Ser Leu Ser Leu 
            740                 745                 750         
Ser Thr Leu Glu Thr Val Lys Ala Val Lys Gly Ile Ile Tyr Ser Tyr 
        755                 760                 765             
Phe Ser Thr Ala Leu Asn Ala Ser Lys Asn Asn Pro Ile Ser Asp Glu 
    770                 775                 780                 
Gln Arg Lys Glu Phe Asp Pro Glu Leu Phe Ala Leu Leu Glu Lys Leu 
785                 790                 795                 800 
Glu Leu Ile Arg Thr Arg Lys Lys Lys Gln Lys Val Glu Arg Ile Ala 
                805                 810                 815     
Asn Ser Leu Ile Gln Thr Cys Leu Glu Asn Asn Ile Lys Phe Ile Arg 
            820                 825                 830         
Gly Glu Gly Asp Leu Ser Thr Thr Asn Asn Ala Thr Lys Lys Lys Ala 
        835                 840                 845             
Asn Ser Arg Ser Met Asp Trp Leu Ala Arg Gly Val Phe Asn Lys Ile 
    850                 855                 860                 
Arg Gln Leu Ala Pro Met His Asn Ile Thr Leu Phe Gly Cys Gly Ser 
865                 870                 875                 880 
Leu Tyr Thr Ser His Gln Asp Pro Leu Val His Arg Asn Pro Asp Lys 
                885                 890                 895     
Ala Met Lys Cys Arg Trp Ala Ala Ile Pro Val Lys Asp Ile Gly Asp 
            900                 905                 910         
Trp Val Leu Arg Lys Leu Ser Gln Asn Leu Arg Ala Lys Asn Gly Gly 
        915                 920                 925             
Thr Gly Glu Tyr Tyr His Gln Gly Val Lys Glu Phe Leu Ser His Tyr 
    930                 935                 940                 
Glu Leu Gln Asp Leu Glu Glu Glu Leu Leu Lys Trp Arg Ser Asp Arg 
945                 950                 955                 960 
Lys Ser Asn Ile Pro Cys Trp Val Leu Gln Asn Arg Leu Ala Glu Lys 
                965                 970                 975     
Leu Gly Asn Lys Glu Ala Val Val Tyr Ile Pro Val Arg Gly Gly Arg 
            980                 985                 990         
Ile Tyr Phe Ala Thr His Lys Val  Ala Thr Gly Ala Val  Ser Ile Val 
        995                 1000                 1005             
Phe Asp  Gln Lys Gln Val Trp  Val Cys Asn Ala Asp  His Val Ala Ala 
    1010                 1015                 1020                 
Ala  Asn Ile Ala Leu Thr  Val Lys Gly Ile Gly  Glu Gln Ser Ser Asp  
1025                 1030                 1035                 1040 
Glu Glu Asn Pro Asp  Gly Ser Arg Ile Lys  Leu Gln Leu Thr Ser  
                1045                 1050                 1055 

<210>  13
<211>  1093
<212>  PRT
<213>  Artificial Sequence

<400>  13
Met Ser Asn Lys Glu Lys Asn Ala Ser Glu Thr Arg Lys Ala Tyr Thr 
1               5                   10                  15      
Thr Lys Met Ile Pro Arg Ser His Asp Arg Met Lys Leu Leu Gly Asn 
            20                  25                  30          
Phe Met Asp Tyr Leu Met Asp Gly Thr Pro Ile Phe Phe Glu Leu Trp 
        35                  40                  45              
Asn Gln Phe Gly Gly Gly Ile Asp Arg Asp Ile Ile Ser Gly Thr Ala 
    50                  55                  60                  
Asn Lys Asp Lys Ile Ser Asp Asp Leu Leu Leu Ala Val Asn Trp Phe 
65                  70                  75                  80  
Lys Val Met Pro Ile Asn Ser Lys Pro Gln Gly Val Ser Pro Ser Asn 
                85                  90                  95      
Leu Ala Asn Leu Phe Gln Gln Tyr Ser Gly Ser Glu Pro Asp Ile Gln 
            100                 105                 110         
Ala Gln Glu Tyr Phe Ala Ser Asn Phe Asp Thr Glu Lys His Gln Trp 
        115                 120                 125             
Lys Asp Met Arg Val Glu Tyr Glu Arg Leu Leu Ala Glu Leu Gln Leu 
    130                 135                 140                 
Ser Arg Ser Asp Met His His Asp Leu Lys Leu Met Tyr Lys Glu Lys 
145                 150                 155                 160 
Cys Ile Gly Leu Ser Leu Ser Thr Ala His Tyr Ile Thr Ser Val Met 
                165                 170                 175     
Phe Gly Thr Gly Ala Lys Asn Asn Arg Gln Thr Lys His Gln Phe Tyr 
            180                 185                 190         
Ser Lys Val Ile Gln Leu Leu Glu Glu Ser Thr Gln Ile Asn Ser Val 
        195                 200                 205             
Glu Gln Leu Ala Ser Ile Ile Leu Lys Ala Gly Asp Cys Asp Ser Tyr 
    210                 215                 220                 
Arg Lys Leu Arg Ile Arg Cys Ser Arg Lys Gly Ala Thr Pro Ser Ile 
225                 230                 235                 240 
Leu Lys Ile Val Gln Asp Tyr Glu Leu Gly Thr Asn His Asp Asp Glu 
                245                 250                 255     
Val Asn Val Pro Ser Leu Ile Ala Asn Leu Lys Glu Lys Leu Gly Arg 
            260                 265                 270         
Phe Glu Tyr Glu Cys Glu Trp Lys Cys Met Glu Lys Ile Lys Ala Phe 
        275                 280                 285             
Leu Ala Ser Lys Val Gly Pro Tyr Tyr Leu Gly Ser Tyr Ser Ala Met 
    290                 295                 300                 
Leu Glu Asn Ala Leu Ser Pro Ile Lys Gly Met Thr Thr Lys Asn Cys 
305                 310                 315                 320 
Lys Phe Val Leu Lys Gln Ile Asp Ala Lys Asn Asp Ile Lys Tyr Glu 
                325                 330                 335     
Asn Glu Pro Phe Gly Lys Ile Val Glu Gly Phe Phe Asp Ser Pro Tyr 
            340                 345                 350         
Phe Glu Ser Asp Thr Asn Val Lys Trp Val Leu His Pro His His Ile 
        355                 360                 365             
Gly Glu Ser Asn Ile Lys Thr Leu Trp Glu Asp Leu Asn Ala Ile His 
    370                 375                 380                 
Ser Lys Tyr Glu Glu Asp Ile Ala Ser Leu Ser Glu Asp Lys Lys Glu 
385                 390                 395                 400 
Lys Arg Ile Lys Val Tyr Gln Gly Asp Val Cys Gln Thr Ile Asn Thr 
                405                 410                 415     
Tyr Cys Glu Glu Val Gly Lys Glu Ala Lys Thr Pro Leu Val Gln Leu 
            420                 425                 430         
Leu Arg Tyr Leu Tyr Ser Arg Lys Asp Asp Ile Ala Val Asp Lys Ile 
        435                 440                 445             
Ile Asp Gly Ile Thr Phe Leu Ser Lys Lys His Lys Val Glu Lys Gln 
    450                 455                 460                 
Lys Ile Asn Pro Val Ile Gln Lys Tyr Pro Ser Phe Asn Phe Gly Asn 
465                 470                 475                 480 
Asn Ser Lys Leu Leu Gly Lys Ile Ile Ser Pro Lys Asp Lys Leu Lys 
                485                 490                 495     
His Asn Leu Lys Cys Asn Arg Asn Gln Val Asp Asn Tyr Ile Trp Ile 
            500                 505                 510         
Glu Ile Lys Val Leu Asn Thr Lys Thr Met Arg Trp Glu Lys His His 
        515                 520                 525             
Tyr Ala Leu Ser Ser Thr Arg Phe Leu Glu Glu Val Tyr Tyr Pro Ala 
    530                 535                 540                 
Thr Ser Glu Asn Pro Pro Asp Ala Leu Ala Ala Arg Phe Arg Thr Lys 
545                 550                 555                 560 
Thr Asn Gly Tyr Glu Gly Lys Pro Ala Leu Ser Ala Glu Gln Ile Glu 
                565                 570                 575     
Gln Ile Arg Ser Ala Pro Val Gly Leu Arg Lys Val Lys Lys Arg Gln 
            580                 585                 590         
Met Arg Leu Glu Ala Ala Arg Gln Gln Asn Leu Leu Pro Arg Tyr Thr 
        595                 600                 605             
Trp Gly Lys Asp Phe Asn Ile Asn Ile Cys Lys Arg Gly Asn Asn Phe 
    610                 615                 620                 
Glu Val Thr Leu Ala Thr Lys Val Lys Lys Lys Lys Glu Lys Asn Tyr 
625                 630                 635                 640 
Lys Val Val Leu Gly Tyr Asp Ala Asn Ile Val Arg Lys Asn Thr Tyr 
                645                 650                 655     
Ala Ala Ile Glu Ala His Ala Asn Gly Asp Gly Val Ile Asp Tyr Asn 
            660                 665                 670         
Asp Leu Pro Val Lys Pro Ile Glu Ser Gly Phe Val Thr Val Glu Ser 
        675                 680                 685             
Gln Val Arg Asp Lys Ser Tyr Asp Gln Leu Ser Tyr Asn Gly Val Lys 
    690                 695                 700                 
Leu Leu Tyr Cys Lys Pro His Val Glu Ser Arg Arg Ser Phe Leu Glu 
705                 710                 715                 720 
Lys Tyr Arg Asn Gly Thr Met Lys Asp Asn Arg Gly Asn Asn Ile Gln 
                725                 730                 735     
Ile Asp Phe Met Lys Asp Phe Glu Ala Ile Ala Asp Asp Glu Thr Ser 
            740                 745                 750         
Leu Tyr Tyr Phe Asn Met Lys Tyr Cys Lys Leu Leu Gln Ser Ser Ile 
        755                 760                 765             
Arg Asn His Ser Ser Gln Ala Lys Glu Tyr Arg Glu Glu Ile Phe Glu 
    770                 775                 780                 
Leu Leu Arg Asp Gly Lys Leu Ser Val Leu Lys Leu Ser Ser Leu Ser 
785                 790                 795                 800 
Asn Leu Ser Phe Val Met Phe Lys Val Ala Lys Ser Leu Ile Gly Thr 
                805                 810                 815     
Tyr Phe Gly His Leu Leu Lys Lys Pro Lys Asn Ser Lys Ser Asp Val 
            820                 825                 830         
Lys Ala Pro Pro Ile Thr Asp Glu Asp Lys Gln Lys Ala Asp Pro Glu 
        835                 840                 845             
Met Phe Ala Leu Arg Leu Ala Leu Glu Glu Lys Arg Leu Asn Lys Val 
    850                 855                 860                 
Lys Ser Lys Lys Glu Val Ile Ala Asn Lys Ile Val Ala Lys Ala Leu 
865                 870                 875                 880 
Glu Leu Arg Asp Lys Tyr Gly Pro Val Leu Ile Lys Gly Glu Asn Ile 
                885                 890                 895     
Ser Asp Thr Thr Lys Lys Gly Lys Lys Ser Ser Thr Asn Ser Phe Leu 
            900                 905                 910         
Met Asp Trp Leu Ala Arg Gly Val Ala Asn Lys Val Lys Glu Met Val 
        915                 920                 925             
Met Met His Gln Gly Leu Glu Phe Val Glu Val Asn Pro Asn Phe Thr 
    930                 935                 940                 
Ser His Gln Asp Pro Phe Val His Lys Asn Pro Glu Asn Thr Phe Arg 
945                 950                 955                 960 
Ala Arg Tyr Ser Arg Cys Thr Pro Ser Glu Leu Thr Glu Lys Asn Arg 
                965                 970                 975     
Lys Glu Ile Leu Ser Phe Leu Ser Asp Lys Pro Ser Lys Arg Pro Thr 
            980                 985                 990         
Asn Ala Tyr Tyr Asn Glu Gly Ala  Met Ala Phe Leu Ala  Thr Tyr Gly 
        995                 1000                 1005             
Leu Lys  Lys Asn Asp Val Leu  Gly Val Ser Leu Glu  Lys Phe Lys Gln 
    1010                 1015                 1020                 
Ile  Met Ala Asn Ile Leu  His Gln Arg Ser Glu  Asp Gln Leu Leu Phe  
1025                 1030                 1035                 1040 
Pro Ser Arg Gly Gly  Met Phe Tyr Leu Ala  Thr Tyr Lys Leu Asp  Ala 
                1045                 1050                 1055     
Asp Ala Thr Ser  Val Asn Trp Asn Gly  Lys Gln Phe Trp Val  Cys Asn 
            1060                 1065                 1070         
Ala Asp Leu  Val Ala Ala Tyr Asn  Val Gly Leu Val Asp  Ile Gln Lys 
        1075                 1080                 1085             
Asp Phe  Lys Lys Lys 
    1090             

<210>  15
<211>  1114
<212>  PRT
<213>  Artificial Sequence

<400>  15
Met Ser Asn Lys Glu Lys Asn Ala Ser Glu Thr Arg Lys Ala Tyr Thr 
1               5                   10                  15      
Thr Lys Met Ile Pro Arg Ser His Asp Arg Met Lys Leu Leu Gly Asn 
            20                  25                  30          
Phe Met Asp Tyr Leu Met Asp Gly Thr Pro Ile Phe Phe Glu Leu Trp 
        35                  40                  45              
Asn Gln Phe Gly Gly Gly Ile Asp Arg Asp Ile Ile Met Ser Ser Ala 
    50                  55                  60                  
Ile Lys Ser Tyr Lys Ser Val Leu Arg Pro Asn Glu Arg Lys Asn Gln 
65                  70                  75                  80  
Leu Leu Lys Ser Thr Ile Gln Cys Leu Glu Asp Gly Ser Ala Phe Phe 
                85                  90                  95      
Phe Lys Met Leu Gln Gly Leu Phe Gly Gly Ile Thr Pro Glu Ile Val 
            100                 105                 110         
Arg Phe Ser Thr Glu Gln Glu Lys Gln Gln Gln Asp Ile Ala Leu Trp 
        115                 120                 125             
Cys Ala Val Asn Trp Phe Arg Pro Val Ser Gln Asp Ser Leu Thr His 
    130                 135                 140                 
Thr Ile Ala Ser Asp Asn Leu Val Glu Lys Phe Glu Glu Tyr Tyr Gly 
145                 150                 155                 160 
Gly Thr Ala Ser Asp Ala Ile Lys Gln Tyr Phe Ser Ala Ser Ile Gly 
                165                 170                 175     
Glu Ser Tyr Tyr Trp Asn Asp Cys Arg Gln Gln Tyr Tyr Asp Leu Cys 
            180                 185                 190         
Arg Glu Leu Gly Val Glu Val Ser Asp Leu Thr His Asp Leu Glu Ile 
        195                 200                 205             
Leu Cys Arg Glu Lys Cys Leu Ala Val Ala Thr Glu Ser Asn Gln Tyr 
    210                 215                 220                 
Asn Ser Ile Ile Ser Val Leu Phe Gly Thr Gly Arg Lys Glu Asp Arg 
225                 230                 235                 240 
Ser Val Lys Leu Arg Ile Thr Lys Lys Ile Leu Glu Ala Ile Ser Asn 
                245                 250                 255     
Leu Lys Glu Ile Pro Lys Asn Val Ala Pro Ile Gln Glu Ile Ile Leu 
            260                 265                 270         
Asn Val Ala Lys Ala Thr Lys Glu Thr Phe Arg Gln Val Tyr Ala Gly 
        275                 280                 285             
Asn Leu Gly Ala Pro Ser Thr Leu Glu Arg Phe Ile Ala Lys Asp Gly 
    290                 295                 300                 
Gln Lys Glu Phe Asp Leu Lys Lys Leu Gln Thr Asp Leu Lys Lys Val 
305                 310                 315                 320 
Ile Arg Gly Lys Ser Lys Glu Arg Asp Trp Cys Cys Gln Glu Glu Leu 
                325                 330                 335     
Arg Ser Tyr Val Glu Gln Asn Thr Ile Gln Tyr Asp Leu Trp Ala Trp 
            340                 345                 350         
Gly Glu Met Phe Asn Lys Ala His Thr Ala Leu Lys Ile Lys Ser Thr 
        355                 360                 365             
Arg Asn Tyr Asn Phe Ala Lys Gln Arg Leu Glu Gln Phe Lys Arg Ile 
    370                 375                 380                 
Gln Ser Leu Asn Asn Leu Leu Val Val Lys Lys Leu Asn Asp Phe Phe 
385                 390                 395                 400 
Asp Ser Glu Phe Phe Ser Gly Glu Glu Thr Tyr Thr Ile Cys Val His 
                405                 410                 415     
His Leu Gly Gly Lys Arg Leu Ser Lys Leu Tyr Lys Ala Trp Glu Asp 
            420                 425                 430         
Asp Pro Ala Asp Pro Glu Asn Ala Ile Val Val Leu Cys Asp Asp Leu 
        435                 440                 445             
Lys Asn Asn Phe Lys Lys Glu Pro Ile Arg Asn Ile Leu Arg Tyr Ile 
    450                 455                 460                 
Phe Thr Ile Arg Gln Glu Cys Ser Ala Gln Asp Ile Leu Ala Ala Ala 
465                 470                 475                 480 
Lys Tyr Asn Gln Gln Leu Asp Arg Tyr Lys Ser Gln Lys Ala Asn Pro 
                485                 490                 495     
Ser Val Leu Gly Asn Gln Gly Phe Thr Trp Arg Asn Ala Val Ile Leu 
            500                 505                 510         
Pro Glu Lys Ala Gln Arg Asn Asp Arg Pro Asn Ser Leu Asp Leu Arg 
        515                 520                 525             
Ile Trp Leu Tyr Leu Lys Leu Arg His Pro Asp Gly Arg Trp Lys Lys 
    530                 535                 540                 
His His Ile Pro Phe Tyr Asp Thr Arg Phe Phe Gln Glu Ile Tyr Ala 
545                 550                 555                 560 
Ala Gly Asn Ser Pro Val Asp Thr Cys Gln Phe Arg Thr Pro Arg Phe 
                565                 570                 575     
Gly Tyr His Leu Pro Lys Leu Thr Asp Gln Thr Ala Ile Arg Val Asn 
            580                 585                 590         
Lys Lys His Val Lys Ala Ala Lys Thr Glu Ala Arg Ile Arg Leu Ala 
        595                 600                 605             
Ile Gln Gln Gly Thr Leu Pro Val Ser Asn Leu Lys Ile Thr Arg Ile 
    610                 615                 620                 
Ser Ala Thr Ile Asn Ser Lys Gly Gln Val Arg Ile Pro Val Lys Phe 
625                 630                 635                 640 
Asp Val Gly Arg Gln Lys Gly Thr Leu Gln Ile Gly Asp Arg Phe Cys 
                645                 650                 655     
Gly Tyr Asp Gln Asn Gln Thr Ala Ser His Ala Tyr Ser Leu Trp Glu 
            660                 665                 670         
Val Val Lys Glu Gly Gln Tyr His Lys Glu Leu Gly Cys Phe Val Arg 
        675                 680                 685             
Phe Ile Ser Ser Gly Asp Ile Val Ser Ile Thr Glu Asn Arg Gly Asn 
    690                 695                 700                 
Gln Phe Asp Gln Leu Ser Tyr Glu Gly Leu Ala Tyr Pro Gln Tyr Ala 
705                 710                 715                 720 
Asp Trp Arg Lys Lys Ala Ser Lys Phe Val Ser Leu Trp Gln Ile Thr 
                725                 730                 735     
Lys Lys Asn Lys Lys Lys Glu Ile Val Thr Val Glu Ala Lys Glu Lys 
            740                 745                 750         
Phe Asp Ala Ile Cys Lys Tyr Gln Pro Arg Leu Tyr Lys Phe Asn Lys 
        755                 760                 765             
Glu Tyr Ala Tyr Leu Leu Arg Asp Ile Val Arg Gly Lys Ser Leu Val 
    770                 775                 780                 
Glu Leu Gln Gln Ile Arg Gln Glu Ile Phe Arg Phe Ile Glu Gln Asp 
785                 790                 795                 800 
Cys Gly Val Thr Arg Leu Gly Ser Leu Ser Leu Ser Thr Leu Glu Thr 
                805                 810                 815     
Val Lys Ala Val Lys Gly Ile Ile Tyr Ser Tyr Phe Ser Thr Ala Leu 
            820                 825                 830         
Asn Ala Ser Lys Asn Asn Pro Ile Ser Asp Glu Gln Arg Lys Glu Phe 
        835                 840                 845             
Asp Pro Glu Leu Phe Ala Leu Leu Glu Lys Leu Glu Leu Ile Arg Thr 
    850                 855                 860                 
Arg Lys Lys Lys Gln Lys Val Glu Arg Ile Ala Asn Ser Leu Ile Gln 
865                 870                 875                 880 
Thr Cys Leu Glu Asn Asn Ile Lys Phe Ile Arg Gly Glu Gly Asp Leu 
                885                 890                 895     
Ser Thr Thr Asn Asn Ala Thr Lys Lys Lys Ala Asn Ser Arg Ser Met 
            900                 905                 910         
Asp Trp Leu Ala Ala Gly Val Phe Asn Lys Ile Arg Gln Leu Ala Pro 
        915                 920                 925             
Met His Asn Ile Thr Leu Phe Gly Cys Gly Ser Leu Tyr Thr Ser His 
    930                 935                 940                 
Gln Asp Pro Leu Val His Arg Asn Pro Asp Lys Ala Met Lys Cys Arg 
945                 950                 955                 960 
Trp Ala Ala Ile Pro Val Lys Asp Ile Gly Asp Trp Val Leu Arg Lys 
                965                 970                 975     
Leu Ser Gln Asn Leu Arg Ala Lys Asn Ile Gly Thr Gly Glu Tyr Tyr 
            980                 985                 990         
His Gln Gly Val Lys Glu Phe Leu  Ser His Tyr Glu Leu  Gln Asp Leu 
        995                 1000                 1005             
Glu Glu  Glu Leu Leu Lys Trp  Arg Ser Asp Arg Lys  Ser Asn Ile Pro 
    1010                 1015                 1020                 
Cys  Trp Val Leu Gln Asn  Arg Leu Ala Glu Lys  Leu Gly Asn Lys Glu  
1025                 1030                 1035                 1040 
Ala Val Val Tyr Ile  Pro Val Arg Gly Gly  Arg Ile Tyr Phe Ala  Thr 
                1045                 1050                 1055     
His Lys Val Ala  Thr Gly Ala Val Ser  Ile Val Phe Asp Gln  Lys Gln 
            1060                 1065                 1070         
Val Trp Val  Cys Asn Ala Asp His  Val Ala Ala Ala Asn  Ile Ala Leu 
        1075                 1080                 1085             
Thr Val  Lys Gly Ile Gly Glu  Gln Ser Ser Asp Glu  Glu Asn Pro Asp 
    1090                 1095                 1100                 
Gly  Ser Arg Ile Lys Leu  Gln Leu Thr Ser 
1105                 1110                 

<210>  15
<211>  1054
<212>  PRT
<213>  Artificial Sequence

<400>  15
Met Ser Ser Ala Ile Lys Ser Tyr Lys Ser Val Leu Arg Pro Asn Glu 
1               5                   10                  15      
Arg Lys Asn Gln Leu Leu Lys Ser Thr Ile Gln Cys Leu Glu Asp Gly 
            20                  25                  30          
Ser Ala Phe Phe Phe Lys Met Leu Gln Gly Leu Phe Gly Gly Ile Thr 
        35                  40                  45              
Pro Glu Ile Val Arg Phe Ser Thr Glu Gln Glu Lys Gln Gln Gln Asp 
    50                  55                  60                  
Ile Ala Leu Trp Cys Ala Val Asn Trp Phe Arg Pro Val Ser Gln Asp 
65                  70                  75                  80  
Ser Leu Thr His Thr Ile Ala Ser Asp Asn Leu Val Glu Lys Phe Glu 
                85                  90                  95      
Glu Tyr Tyr Gly Gly Thr Ala Ser Asp Ala Ile Lys Gln Tyr Phe Ser 
            100                 105                 110         
Ala Ser Ile Gly Glu Ser Tyr Tyr Trp Asn Asp Cys Arg Gln Gln Tyr 
        115                 120                 125             
Tyr Asp Leu Cys Arg Glu Leu Gly Val Glu Val Ser Asp Leu Thr His 
    130                 135                 140                 
Asp Leu Glu Ile Leu Cys Arg Glu Lys Cys Leu Ala Val Ala Thr Glu 
145                 150                 155                 160 
Ser Asn Gln Tyr Asn Ser Ile Ile Ser Val Leu Phe Gly Thr Gly Arg 
                165                 170                 175     
Lys Glu Asp Arg Ser Val Lys Leu Arg Ile Thr Lys Lys Ile Leu Glu 
            180                 185                 190         
Ala Ile Ser Asn Leu Lys Glu Ile Pro Lys Asn Val Ala Pro Ile Gln 
        195                 200                 205             
Glu Ile Ile Leu Asn Val Ala Lys Ala Thr Lys Glu Thr Phe Arg Gln 
    210                 215                 220                 
Val Tyr Ala Gly Asn Leu Gly Ala Pro Ser Thr Leu Glu Arg Phe Ile 
225                 230                 235                 240 
Ala Lys Asp Gly Gln Lys Glu Phe Asp Leu Lys Lys Leu Gln Thr Asp 
                245                 250                 255     
Leu Lys Lys Val Ile Arg Gly Lys Ser Lys Glu Arg Asp Trp Cys Cys 
            260                 265                 270         
Gln Glu Glu Leu Arg Ser Tyr Val Glu Gln Asn Thr Ile Gln Tyr Asp 
        275                 280                 285             
Leu Trp Ala Trp Gly Glu Met Phe Asn Lys Ala His Thr Ala Leu Lys 
    290                 295                 300                 
Ile Lys Ser Thr Arg Asn Tyr Asn Phe Ala Lys Gln Arg Leu Glu Gln 
305                 310                 315                 320 
Phe Lys Arg Ile Gln Ser Leu Asn Asn Leu Leu Val Val Lys Lys Leu 
                325                 330                 335     
Asn Asp Phe Phe Asp Ser Glu Phe Phe Ser Gly Glu Glu Thr Tyr Thr 
            340                 345                 350         
Ile Cys Val His His Leu Gly Gly Lys Arg Leu Ser Lys Leu Tyr Lys 
        355                 360                 365             
Ala Trp Glu Asp Asp Pro Ala Asp Pro Glu Asn Ala Ile Val Val Leu 
    370                 375                 380                 
Cys Asp Asp Leu Lys Asn Asn Phe Lys Lys Glu Pro Ile Arg Asn Ile 
385                 390                 395                 400 
Leu Arg Tyr Ile Phe Thr Ile Arg Gln Glu Cys Ser Ala Gln Asp Ile 
                405                 410                 415     
Leu Ala Ala Ala Lys Tyr Asn Gln Gln Leu Asp Arg Tyr Lys Ser Gln 
            420                 425                 430         
Lys Ala Asn Pro Ser Val Leu Gly Asn Gln Gly Phe Thr Trp Arg Asn 
        435                 440                 445             
Ala Val Ile Leu Pro Glu Lys Ala Gln Arg Asn Asp Arg Pro Asn Ser 
    450                 455                 460                 
Leu Asp Leu Arg Ile Trp Leu Tyr Leu Lys Leu Arg His Pro Asp Gly 
465                 470                 475                 480 
Arg Trp Lys Lys His His Ile Pro Phe Tyr Asp Thr Arg Phe Phe Gln 
                485                 490                 495     
Glu Ile Tyr Ala Ala Gly Asn Ser Pro Val Asp Thr Cys Gln Phe Arg 
            500                 505                 510         
Thr Pro Arg Phe Gly Tyr His Leu Pro Lys Leu Thr Asp Gln Thr Ala 
        515                 520                 525             
Ile Arg Val Asn Lys Lys His Val Lys Ala Ala Lys Thr Glu Ala Arg 
    530                 535                 540                 
Ile Arg Leu Ala Ile Gln Gln Gly Thr Leu Pro Val Ser Asn Leu Lys 
545                 550                 555                 560 
Ile Thr Arg Ile Ser Ala Thr Ile Asn Ser Lys Gly Gln Val Arg Ile 
                565                 570                 575     
Pro Val Lys Phe Asp Val Gly Arg Gln Lys Gly Thr Leu Gln Ile Gly 
            580                 585                 590         
Asp Arg Phe Cys Gly Tyr Asp Gln Asn Gln Thr Ala Ser His Ala Tyr 
        595                 600                 605             
Ser Leu Trp Glu Val Val Lys Glu Gly Gln Tyr His Lys Glu Leu Gly 
    610                 615                 620                 
Cys Phe Val Arg Phe Ile Ser Ser Gly Asp Ile Val Ser Ile Thr Glu 
625                 630                 635                 640 
Asn Arg Gly Asn Gln Phe Asp Gln Leu Ser Tyr Glu Gly Leu Ala Tyr 
                645                 650                 655     
Pro Gln Tyr Ala Asp Trp Arg Lys Lys Ala Ser Lys Phe Val Ser Leu 
            660                 665                 670         
Trp Gln Ile Thr Lys Lys Asn Lys Lys Lys Glu Ile Val Thr Val Glu 
        675                 680                 685             
Ala Lys Glu Lys Phe Asp Ala Ile Cys Lys Tyr Gln Pro Arg Leu Tyr 
    690                 695                 700                 
Lys Phe Asn Lys Glu Tyr Ala Tyr Leu Leu Arg Asp Ile Val Arg Gly 
705                 710                 715                 720 
Lys Ser Leu Val Glu Leu Gln Gln Ile Arg Gln Glu Ile Phe Arg Phe 
                725                 730                 735     
Ile Glu Gln Asp Cys Gly Val Thr Arg Leu Gly Ser Leu Ser Leu Ser 
            740                 745                 750         
Thr Leu Glu Thr Val Lys Ala Val Lys Gly Ile Ile Tyr Ser Tyr Phe 
        755                 760                 765             
Ser Thr Ala Leu Asn Ala Ser Lys Asn Asn Pro Ile Ser Asp Glu Gln 
    770                 775                 780                 
Arg Lys Glu Phe Asp Pro Glu Leu Phe Ala Leu Leu Glu Lys Leu Glu 
785                 790                 795                 800 
Leu Ile Arg Thr Arg Lys Lys Lys Gln Lys Val Glu Arg Ile Ala Asn 
                805                 810                 815     
Ser Leu Ile Gln Thr Cys Leu Glu Asn Asn Ile Lys Phe Ile Arg Gly 
            820                 825                 830         
Glu Gly Asp Leu Ser Thr Thr Asn Asn Ala Thr Lys Lys Lys Ala Asn 
        835                 840                 845             
Ser Arg Ser Met Asp Trp Leu Ala Arg Gly Val Phe Ala Lys Ile Arg 
    850                 855                 860                 
Gln Leu Ala Pro Met His Asn Ile Thr Leu Phe Gly Cys Gly Ser Leu 
865                 870                 875                 880 
Tyr Thr Ser His Gln Asp Pro Leu Val His Arg Asn Pro Asp Lys Ala 
                885                 890                 895     
Met Lys Cys Arg Trp Ala Ala Ile Pro Val Lys Asp Ile Gly Asp Trp 
            900                 905                 910         
Val Leu Arg Lys Leu Ser Gln Asn Leu Arg Ala Lys Asn Ile Gly Thr 
        915                 920                 925             
Gly Glu Tyr Tyr His Gln Gly Val Lys Glu Phe Leu Ser His Tyr Glu 
    930                 935                 940                 
Leu Gln Asp Leu Glu Glu Glu Leu Leu Lys Trp Arg Ser Asp Arg Lys 
945                 950                 955                 960 
Ser Asn Ile Pro Cys Trp Val Leu Gln Asn Arg Leu Ala Glu Lys Leu 
                965                 970                 975     
Gly Asn Lys Glu Ala Val Val Tyr Ile Pro Val Arg Gly Gly Arg Ile 
            980                 985                 990         
Tyr Phe Ala Thr His Lys Val Ala  Thr Gly Ala Val Ser  Ile Val Phe 
        995                 1000                 1005             
Asp Gln  Lys Gln Val Trp Val  Cys Asn Ala Asp His  Val Ala Ala Ala 
    1010                 1015                 1020                 
Asn  Ile Ala Leu Thr Val  Lys Gly Ile Gly Glu  Gln Ser Ser Asp Glu  
1025                 1030                 1035                 1040 
Glu Asn Pro Asp Gly  Ser Arg Ile Lys Leu  Gln Leu Thr Ser 
                1045                 1050                 

<210>  16
<211>  1054
<212>  PRT
<213>  Artificial Sequence

<400>  16
Met Ser Ser Ala Ile Lys Ser Tyr Lys Ser Val Leu Arg Pro Asn Glu 
1               5                   10                  15      
Arg Lys Asn Gln Leu Leu Lys Ser Thr Ile Gln Cys Leu Glu Asp Gly 
            20                  25                  30          
Ser Ala Phe Phe Phe Lys Met Leu Gln Gly Leu Phe Gly Gly Ile Thr 
        35                  40                  45              
Pro Glu Ile Val Arg Phe Ser Thr Glu Gln Glu Lys Gln Gln Gln Asp 
    50                  55                  60                  
Ile Ala Leu Trp Cys Ala Val Asn Trp Phe Arg Pro Val Ser Gln Asp 
65                  70                  75                  80  
Ser Leu Thr His Thr Ile Ala Ser Asp Asn Leu Val Glu Lys Phe Glu 
                85                  90                  95      
Glu Tyr Tyr Gly Gly Thr Ala Ser Asp Ala Ile Lys Gln Tyr Phe Ser 
            100                 105                 110         
Ala Ser Ile Gly Glu Ser Tyr Tyr Trp Asn Asp Cys Arg Gln Gln Tyr 
        115                 120                 125             
Tyr Asp Leu Cys Arg Glu Leu Gly Val Glu Val Ser Asp Leu Thr His 
    130                 135                 140                 
Asp Leu Glu Ile Leu Cys Arg Glu Lys Cys Leu Ala Val Ala Thr Glu 
145                 150                 155                 160 
Ser Asn Gln Tyr Asn Ser Ile Ile Ser Val Leu Phe Gly Thr Gly Arg 
                165                 170                 175     
Lys Glu Asp Arg Ser Val Lys Leu Arg Ile Thr Lys Lys Ile Leu Glu 
            180                 185                 190         
Ala Ile Ser Asn Leu Lys Glu Ile Pro Lys Asn Val Ala Pro Ile Gln 
        195                 200                 205             
Glu Ile Ile Leu Asn Val Ala Lys Ala Thr Lys Glu Thr Phe Arg Gln 
    210                 215                 220                 
Val Tyr Ala Gly Asn Leu Gly Ala Pro Ser Thr Leu Glu Arg Phe Ile 
225                 230                 235                 240 
Ala Lys Asp Gly Gln Lys Glu Phe Asp Leu Lys Lys Leu Gln Thr Asp 
                245                 250                 255     
Leu Lys Lys Val Ile Arg Gly Lys Ser Lys Glu Arg Asp Trp Cys Cys 
            260                 265                 270         
Gln Glu Glu Leu Arg Ser Tyr Val Glu Gln Asn Thr Ile Gln Tyr Asp 
        275                 280                 285             
Leu Trp Ala Trp Gly Glu Met Phe Asn Lys Ala His Thr Ala Leu Lys 
    290                 295                 300                 
Ile Lys Ser Thr Arg Asn Tyr Asn Phe Ala Lys Gln Arg Leu Glu Gln 
305                 310                 315                 320 
Phe Lys Arg Ile Gln Ser Leu Asn Asn Leu Leu Val Val Lys Lys Leu 
                325                 330                 335     
Asn Asp Phe Phe Asp Ser Glu Phe Phe Ser Gly Glu Glu Thr Tyr Thr 
            340                 345                 350         
Ile Cys Val His His Leu Gly Gly Lys Arg Leu Ser Lys Leu Tyr Lys 
        355                 360                 365             
Ala Trp Glu Asp Asp Pro Ala Asp Pro Glu Asn Ala Ile Val Val Leu 
    370                 375                 380                 
Cys Asp Asp Leu Lys Asn Asn Phe Lys Lys Glu Pro Ile Arg Asn Ile 
385                 390                 395                 400 
Leu Arg Tyr Ile Phe Thr Ile Arg Gln Glu Cys Ser Ala Gln Asp Ile 
                405                 410                 415     
Leu Ala Ala Ala Lys Tyr Asn Gln Gln Leu Asp Arg Tyr Lys Ser Gln 
            420                 425                 430         
Lys Ala Asn Pro Ser Val Leu Gly Asn Gln Gly Phe Thr Trp Arg Asn 
        435                 440                 445             
Ala Val Ile Leu Pro Glu Lys Ala Gln Arg Asn Asp Arg Pro Asn Ser 
    450                 455                 460                 
Leu Asp Leu Arg Ile Trp Leu Tyr Leu Lys Leu Arg His Pro Asp Gly 
465                 470                 475                 480 
Arg Trp Lys Lys His His Ile Pro Phe Tyr Asp Thr Arg Phe Phe Gln 
                485                 490                 495     
Glu Ile Tyr Ala Ala Gly Asn Ser Pro Val Asp Thr Cys Gln Phe Arg 
            500                 505                 510         
Thr Pro Arg Phe Gly Tyr His Leu Pro Lys Leu Thr Asp Gln Thr Ala 
        515                 520                 525             
Ile Arg Val Asn Lys Lys His Val Lys Ala Ala Lys Thr Glu Ala Arg 
    530                 535                 540                 
Ile Arg Leu Ala Ile Gln Gln Gly Thr Leu Pro Val Ser Asn Leu Lys 
545                 550                 555                 560 
Ile Thr Arg Ile Ser Ala Thr Ile Asn Ser Lys Gly Gln Val Arg Ile 
                565                 570                 575     
Pro Val Lys Phe Asp Val Gly Arg Gln Lys Gly Thr Leu Gln Ile Gly 
            580                 585                 590         
Asp Arg Phe Cys Gly Tyr Asp Gln Asn Gln Thr Ala Ser His Ala Tyr 
        595                 600                 605             
Ser Leu Trp Glu Val Val Lys Glu Gly Gln Tyr His Lys Glu Leu Gly 
    610                 615                 620                 
Cys Phe Val Arg Phe Ile Ser Ser Gly Asp Ile Val Ser Ile Thr Glu 
625                 630                 635                 640 
Asn Arg Gly Asn Gln Phe Asp Gln Leu Ser Tyr Glu Gly Leu Ala Tyr 
                645                 650                 655     
Pro Gln Tyr Ala Asp Trp Arg Lys Lys Ala Ser Lys Phe Val Ser Leu 
            660                 665                 670         
Trp Gln Ile Thr Lys Lys Asn Lys Lys Lys Glu Ile Val Thr Val Glu 
        675                 680                 685             
Ala Lys Glu Lys Phe Asp Ala Ile Cys Lys Tyr Gln Pro Arg Leu Tyr 
    690                 695                 700                 
Lys Phe Asn Lys Glu Tyr Ala Tyr Leu Leu Arg Asp Ile Val Arg Gly 
705                 710                 715                 720 
Lys Ser Leu Val Glu Leu Gln Gln Ile Arg Gln Glu Ile Phe Arg Phe 
                725                 730                 735     
Ile Glu Gln Asp Cys Gly Val Thr Arg Leu Gly Ser Leu Ser Leu Ser 
            740                 745                 750         
Thr Leu Glu Thr Val Lys Ala Val Lys Gly Ile Ile Tyr Ser Tyr Phe 
        755                 760                 765             
Ser Thr Ala Leu Asn Ala Ser Lys Asn Asn Pro Ile Ser Asp Glu Gln 
    770                 775                 780                 
Arg Lys Glu Phe Asp Pro Glu Leu Phe Ala Leu Leu Glu Lys Leu Glu 
785                 790                 795                 800 
Leu Ile Arg Thr Arg Lys Ala Lys Gln Lys Val Glu Arg Ile Ala Asn 
                805                 810                 815     
Ser Leu Ile Gln Thr Cys Leu Glu Asn Asn Ile Lys Phe Ile Arg Gly 
            820                 825                 830         
Glu Gly Asp Leu Ser Thr Thr Asn Asn Ala Thr Lys Lys Lys Ala Asn 
        835                 840                 845             
Ser Arg Ser Met Asp Trp Leu Ala Arg Gly Val Phe Asn Lys Ile Arg 
    850                 855                 860                 
Gln Leu Ala Pro Met His Asn Ile Thr Leu Phe Gly Cys Gly Ser Leu 
865                 870                 875                 880 
Tyr Thr Ser His Gln Asp Pro Leu Val His Arg Asn Pro Asp Lys Ala 
                885                 890                 895     
Met Lys Cys Arg Trp Ala Ala Ile Pro Val Lys Asp Ile Gly Asp Trp 
            900                 905                 910         
Val Leu Arg Lys Leu Ser Gln Asn Leu Arg Ala Lys Asn Ile Gly Thr 
        915                 920                 925             
Gly Glu Tyr Tyr His Gln Gly Val Lys Glu Phe Leu Ser His Tyr Glu 
    930                 935                 940                 
Leu Gln Asp Leu Glu Glu Glu Leu Leu Lys Trp Arg Ser Asp Arg Lys 
945                 950                 955                 960 
Ser Asn Ile Pro Cys Trp Val Leu Gln Asn Arg Leu Ala Glu Lys Leu 
                965                 970                 975     
Gly Asn Lys Glu Ala Val Val Tyr Ile Pro Val Arg Gly Gly Arg Ile 
            980                 985                 990         
Tyr Phe Ala Thr His Lys Val Ala  Thr Gly Ala Val Ser  Ile Val Phe 
        995                 1000                 1005             
Asp Gln  Lys Gln Val Trp Val  Cys Asn Ala Asp His  Val Ala Ala Ala 
    1010                 1015                 1020                 
Asn  Ile Ala Leu Thr Val  Lys Gly Ile Gly Glu  Gln Ser Ser Asp Glu  
1025                 1030                 1035                 1040 
Glu Asn Pro Asp Gly  Ser Arg Ile Lys Leu  Gln Leu Thr Ser 
                1045                 1050                 

<210>  17
<211>  1054
<212>  PRT
<213>  Artificial Sequence

<400>  17
Met Ser Ser Ala Ile Lys Ser Tyr Lys Ser Val Leu Arg Pro Asn Glu 
1               5                   10                  15      
Arg Lys Asn Gln Leu Leu Lys Ser Thr Ile Gln Cys Leu Glu Asp Gly 
            20                  25                  30          
Ser Ala Phe Phe Phe Lys Met Leu Gln Gly Leu Phe Gly Gly Ile Thr 
        35                  40                  45              
Pro Glu Ile Val Arg Phe Ser Thr Glu Gln Glu Lys Gln Gln Gln Asp 
    50                  55                  60                  
Ile Ala Leu Trp Cys Ala Val Asn Trp Phe Arg Pro Val Ser Gln Asp 
65                  70                  75                  80  
Ser Leu Thr His Thr Ile Ala Ser Asp Asn Leu Val Glu Lys Phe Glu 
                85                  90                  95      
Glu Tyr Tyr Gly Gly Thr Ala Ser Asp Ala Ile Lys Gln Tyr Phe Ser 
            100                 105                 110         
Ala Ser Ile Gly Glu Ser Tyr Tyr Trp Asn Asp Cys Arg Gln Gln Tyr 
        115                 120                 125             
Tyr Asp Leu Cys Arg Glu Leu Gly Val Glu Val Ser Asp Leu Thr His 
    130                 135                 140                 
Asp Leu Glu Ile Leu Cys Arg Glu Lys Cys Leu Ala Val Ala Thr Glu 
145                 150                 155                 160 
Ser Asn Gln Tyr Asn Ser Ile Ile Ser Val Leu Phe Gly Thr Gly Arg 
                165                 170                 175     
Lys Glu Asp Arg Ser Val Lys Leu Arg Ile Thr Lys Lys Ile Leu Glu 
            180                 185                 190         
Ala Ile Ser Asn Leu Lys Glu Ile Pro Lys Asn Val Ala Pro Ile Gln 
        195                 200                 205             
Glu Ile Ile Leu Asn Val Ala Lys Ala Thr Lys Glu Thr Phe Arg Gln 
    210                 215                 220                 
Val Tyr Ala Gly Asn Leu Gly Ala Pro Ser Thr Leu Glu Arg Phe Ile 
225                 230                 235                 240 
Ala Lys Asp Gly Gln Lys Glu Phe Asp Leu Lys Lys Leu Gln Thr Asp 
                245                 250                 255     
Leu Lys Lys Val Ile Arg Gly Lys Ser Lys Glu Arg Asp Trp Cys Cys 
            260                 265                 270         
Gln Glu Glu Leu Arg Ser Tyr Val Glu Gln Asn Thr Ile Gln Tyr Asp 
        275                 280                 285             
Leu Trp Ala Trp Gly Glu Met Phe Asn Lys Ala His Thr Ala Leu Lys 
    290                 295                 300                 
Ile Lys Ser Thr Arg Asn Tyr Asn Phe Ala Lys Gln Arg Leu Glu Gln 
305                 310                 315                 320 
Phe Lys Arg Ile Gln Ser Leu Asn Asn Leu Leu Val Val Lys Lys Leu 
                325                 330                 335     
Asn Asp Phe Phe Asp Ser Glu Phe Phe Ser Gly Glu Glu Thr Tyr Thr 
            340                 345                 350         
Ile Cys Val His His Leu Gly Gly Lys Arg Leu Ser Lys Leu Tyr Lys 
        355                 360                 365             
Ala Trp Glu Asp Asp Pro Ala Asp Pro Glu Asn Ala Ile Val Val Leu 
    370                 375                 380                 
Cys Asp Asp Leu Lys Asn Asn Phe Lys Lys Glu Pro Ile Arg Asn Ile 
385                 390                 395                 400 
Leu Arg Tyr Ile Phe Thr Ile Arg Gln Glu Cys Ser Ala Gln Asp Ile 
                405                 410                 415     
Leu Ala Ala Ala Lys Tyr Asn Gln Gln Leu Asp Arg Tyr Lys Ser Gln 
            420                 425                 430         
Lys Ala Asn Pro Ser Val Leu Gly Asn Gln Gly Phe Thr Trp Arg Asn 
        435                 440                 445             
Ala Val Ile Leu Pro Glu Lys Ala Gln Arg Asn Asp Arg Pro Asn Ser 
    450                 455                 460                 
Leu Asp Leu Arg Ile Trp Leu Tyr Leu Lys Leu Arg His Pro Asp Gly 
465                 470                 475                 480 
Arg Trp Lys Lys His His Ile Pro Phe Tyr Asp Thr Arg Phe Phe Gln 
                485                 490                 495     
Glu Ile Tyr Ala Ala Gly Asn Ser Pro Val Asp Thr Cys Gln Phe Arg 
            500                 505                 510         
Thr Pro Arg Phe Gly Tyr His Leu Pro Lys Leu Thr Asp Gln Thr Ala 
        515                 520                 525             
Ile Arg Val Asn Lys Lys His Val Lys Ala Ala Lys Thr Glu Ala Arg 
    530                 535                 540                 
Ile Arg Leu Ala Ile Gln Gln Gly Thr Leu Pro Val Ser Asn Leu Lys 
545                 550                 555                 560 
Ile Thr Arg Ile Ser Ala Thr Ile Asn Ser Lys Gly Gln Val Arg Ile 
                565                 570                 575     
Pro Val Lys Phe Asp Val Gly Arg Gln Lys Gly Thr Leu Gln Ile Gly 
            580                 585                 590         
Asp Arg Phe Cys Gly Tyr Asp Gln Asn Gln Thr Ala Ser His Ala Tyr 
        595                 600                 605             
Ser Leu Trp Glu Val Val Lys Glu Gly Gln Tyr His Lys Glu Leu Gly 
    610                 615                 620                 
Cys Phe Val Arg Phe Ile Ser Ser Gly Asp Ile Val Ser Ile Thr Glu 
625                 630                 635                 640 
Asn Arg Gly Asn Gln Phe Asp Gln Leu Ser Tyr Glu Gly Leu Ala Tyr 
                645                 650                 655     
Pro Gln Tyr Ala Asp Trp Arg Lys Lys Ala Ser Lys Phe Val Ser Leu 
            660                 665                 670         
Trp Gln Ile Thr Lys Lys Asn Lys Lys Lys Glu Ile Val Thr Val Glu 
        675                 680                 685             
Ala Lys Glu Lys Phe Asp Ala Ile Cys Lys Tyr Gln Pro Arg Leu Tyr 
    690                 695                 700                 
Lys Phe Asn Lys Glu Tyr Ala Tyr Leu Leu Arg Asp Ile Val Arg Gly 
705                 710                 715                 720 
Lys Ser Leu Val Glu Leu Gln Gln Ile Arg Gln Glu Ile Phe Arg Phe 
                725                 730                 735     
Ile Glu Gln Asp Cys Gly Val Thr Arg Leu Gly Ser Leu Ser Leu Ser 
            740                 745                 750         
Thr Leu Glu Thr Val Lys Ala Val Lys Gly Ile Ile Tyr Ser Tyr Phe 
        755                 760                 765             
Ser Thr Ala Leu Asn Ala Ser Lys Asn Asn Pro Ile Ser Asp Glu Gln 
    770                 775                 780                 
Arg Lys Glu Phe Asp Pro Glu Leu Phe Ala Leu Leu Glu Lys Leu Glu 
785                 790                 795                 800 
Leu Ile Arg Thr Arg Lys Lys Lys Gln Lys Val Glu Arg Ile Ala Asn 
                805                 810                 815     
Ser Leu Ile Gln Thr Cys Leu Glu Asn Asn Ile Lys Phe Ile Arg Gly 
            820                 825                 830         
Glu Gly Asp Leu Ser Thr Thr Asn Asn Ala Thr Lys Lys Lys Ala Ala 
        835                 840                 845             
Ser Arg Ser Met Asp Trp Leu Ala Arg Gly Val Phe Asn Lys Ile Arg 
    850                 855                 860                 
Gln Leu Ala Pro Met His Asn Ile Thr Leu Phe Gly Cys Gly Ser Leu 
865                 870                 875                 880 
Tyr Thr Ser His Gln Asp Pro Leu Val His Arg Asn Pro Asp Lys Ala 
                885                 890                 895     
Met Lys Cys Arg Trp Ala Ala Ile Pro Val Lys Asp Ile Gly Asp Trp 
            900                 905                 910         
Val Leu Arg Lys Leu Ser Gln Asn Leu Arg Ala Lys Asn Ile Gly Thr 
        915                 920                 925             
Gly Glu Tyr Tyr His Gln Gly Val Lys Glu Phe Leu Ser His Tyr Glu 
    930                 935                 940                 
Leu Gln Asp Leu Glu Glu Glu Leu Leu Lys Trp Arg Ser Asp Arg Lys 
945                 950                 955                 960 
Ser Asn Ile Pro Cys Trp Val Leu Gln Asn Arg Leu Ala Glu Lys Leu 
                965                 970                 975     
Gly Asn Lys Glu Ala Val Val Tyr Ile Pro Val Arg Gly Gly Arg Ile 
            980                 985                 990         
Tyr Phe Ala Thr His Lys Val Ala  Thr Gly Ala Val Ser  Ile Val Phe 
        995                 1000                 1005             
Asp Gln  Lys Gln Val Trp Val  Cys Asn Ala Asp His  Val Ala Ala Ala 
    1010                 1015                 1020                 
Asn  Ile Ala Leu Thr Val  Lys Gly Ile Gly Glu  Gln Ser Ser Asp Glu  
1025                 1030                 1035                 1040 
Glu Asn Pro Asp Gly  Ser Arg Ile Lys Leu  Gln Leu Thr Ser 
                1045                 1050                 

<210>  18
<211>  1054
<212>  PRT
<213>  Artificial Sequence

<400>  18
Met Ser Ser Ala Ile Lys Ser Tyr Lys Ser Val Leu Arg Pro Asn Glu 
1               5                   10                  15      
Arg Lys Asn Gln Leu Leu Lys Ser Thr Ile Gln Cys Leu Glu Asp Gly 
            20                  25                  30          
Ser Ala Phe Phe Phe Lys Met Leu Gln Gly Leu Phe Gly Gly Ile Thr 
        35                  40                  45              
Pro Glu Ile Val Arg Phe Ser Thr Glu Gln Glu Lys Gln Gln Gln Asp 
    50                  55                  60                  
Ile Ala Leu Trp Cys Ala Val Asn Trp Phe Arg Pro Val Ser Gln Asp 
65                  70                  75                  80  
Ser Leu Thr His Thr Ile Ala Ser Asp Asn Leu Val Glu Lys Phe Glu 
                85                  90                  95      
Glu Tyr Tyr Gly Gly Thr Ala Ser Asp Ala Ile Lys Gln Tyr Phe Ser 
            100                 105                 110         
Ala Ser Ile Gly Glu Ser Tyr Tyr Trp Asn Asp Cys Arg Gln Gln Tyr 
        115                 120                 125             
Tyr Asp Leu Cys Arg Glu Leu Gly Val Glu Val Ser Asp Leu Thr His 
    130                 135                 140                 
Asp Leu Glu Ile Leu Cys Arg Glu Lys Cys Leu Ala Val Ala Thr Glu 
145                 150                 155                 160 
Ser Asn Gln Tyr Asn Ser Ile Ile Ser Val Leu Phe Gly Thr Gly Arg 
                165                 170                 175     
Lys Glu Asp Arg Ser Val Lys Leu Arg Ile Thr Lys Lys Ile Leu Glu 
            180                 185                 190         
Ala Ile Ser Asn Leu Lys Glu Ile Pro Lys Asn Val Ala Pro Ile Gln 
        195                 200                 205             
Glu Ile Ile Leu Asn Val Ala Lys Ala Thr Lys Glu Thr Phe Arg Gln 
    210                 215                 220                 
Val Tyr Ala Gly Asn Leu Gly Ala Pro Ser Thr Leu Glu Arg Phe Ile 
225                 230                 235                 240 
Ala Lys Asp Gly Gln Lys Glu Phe Asp Leu Lys Lys Leu Gln Thr Asp 
                245                 250                 255     
Leu Lys Lys Val Ile Arg Gly Lys Ser Lys Glu Arg Asp Trp Cys Cys 
            260                 265                 270         
Gln Glu Glu Leu Arg Ser Tyr Val Glu Gln Asn Thr Ile Gln Tyr Asp 
        275                 280                 285             
Leu Trp Ala Trp Gly Glu Met Phe Asn Lys Ala His Thr Ala Leu Lys 
    290                 295                 300                 
Ile Lys Ser Thr Arg Asn Tyr Asn Phe Ala Lys Gln Arg Leu Glu Gln 
305                 310                 315                 320 
Phe Lys Arg Ile Gln Ser Leu Asn Asn Leu Leu Val Val Lys Lys Leu 
                325                 330                 335     
Asn Asp Phe Phe Asp Ser Glu Phe Phe Ser Gly Glu Glu Thr Tyr Thr 
            340                 345                 350         
Ile Cys Val His His Leu Gly Gly Lys Arg Leu Ser Lys Leu Tyr Lys 
        355                 360                 365             
Ala Trp Glu Asp Asp Pro Ala Asp Pro Glu Asn Ala Ile Val Val Leu 
    370                 375                 380                 
Cys Asp Asp Leu Lys Asn Asn Phe Lys Lys Glu Pro Ile Arg Asn Ile 
385                 390                 395                 400 
Leu Arg Tyr Ile Phe Thr Ile Arg Gln Glu Cys Ser Ala Gln Asp Ile 
                405                 410                 415     
Leu Ala Ala Ala Lys Tyr Asn Gln Gln Leu Asp Arg Tyr Lys Ser Gln 
            420                 425                 430         
Lys Ala Asn Pro Ser Val Leu Gly Asn Gln Gly Phe Thr Trp Arg Asn 
        435                 440                 445             
Ala Val Ile Leu Pro Glu Lys Ala Gln Arg Asn Asp Arg Pro Asn Ser 
    450                 455                 460                 
Leu Asp Leu Arg Ile Trp Leu Tyr Leu Lys Leu Arg His Pro Asp Gly 
465                 470                 475                 480 
Arg Trp Lys Lys His His Ile Pro Phe Tyr Asp Thr Arg Phe Phe Gln 
                485                 490                 495     
Glu Ile Tyr Ala Ala Gly Asn Ser Pro Val Asp Thr Cys Gln Phe Arg 
            500                 505                 510         
Thr Pro Arg Phe Gly Tyr His Leu Pro Lys Leu Thr Asp Gln Thr Ala 
        515                 520                 525             
Ile Arg Val Asn Lys Lys His Val Lys Ala Ala Lys Thr Glu Ala Arg 
    530                 535                 540                 
Ile Arg Leu Ala Ile Gln Gln Gly Thr Leu Pro Val Ser Asn Leu Lys 
545                 550                 555                 560 
Ile Thr Arg Ile Ser Ala Thr Ile Asn Ser Lys Gly Gln Val Arg Ile 
                565                 570                 575     
Pro Val Lys Phe Asp Val Gly Arg Gln Lys Gly Thr Leu Gln Ile Gly 
            580                 585                 590         
Asp Arg Phe Cys Gly Tyr Asp Gln Asn Gln Thr Ala Ser His Ala Tyr 
        595                 600                 605             
Ser Leu Trp Glu Val Val Lys Glu Gly Gln Tyr His Lys Glu Leu Gly 
    610                 615                 620                 
Cys Phe Val Arg Phe Ile Ser Ser Gly Asp Ile Val Ser Ile Thr Glu 
625                 630                 635                 640 
Asn Arg Gly Asn Gln Phe Asp Gln Leu Ser Tyr Glu Gly Leu Ala Tyr 
                645                 650                 655     
Pro Gln Tyr Ala Asp Trp Arg Lys Lys Ala Ser Lys Phe Val Ser Leu 
            660                 665                 670         
Trp Gln Ile Thr Lys Lys Asn Lys Lys Lys Glu Ile Val Thr Val Glu 
        675                 680                 685             
Ala Lys Glu Lys Phe Asp Ala Ile Cys Lys Tyr Gln Pro Arg Leu Tyr 
    690                 695                 700                 
Lys Phe Asn Lys Glu Tyr Ala Tyr Leu Leu Ala Asp Ile Val Arg Gly 
705                 710                 715                 720 
Lys Ser Leu Val Glu Leu Gln Gln Ile Arg Gln Glu Ile Phe Arg Phe 
                725                 730                 735     
Ile Glu Gln Asp Cys Gly Val Thr Arg Leu Gly Ser Leu Ser Leu Ser 
            740                 745                 750         
Thr Leu Glu Thr Val Lys Ala Val Lys Gly Ile Ile Tyr Ser Tyr Phe 
        755                 760                 765             
Ser Thr Ala Leu Asn Ala Ser Lys Asn Asn Pro Ile Ser Asp Glu Gln 
    770                 775                 780                 
Arg Lys Glu Phe Asp Pro Glu Leu Phe Ala Leu Leu Glu Lys Leu Glu 
785                 790                 795                 800 
Leu Ile Arg Thr Arg Lys Lys Lys Gln Lys Val Glu Arg Ile Ala Asn 
                805                 810                 815     
Ser Leu Ile Gln Thr Cys Leu Glu Asn Asn Ile Lys Phe Ile Arg Gly 
            820                 825                 830         
Glu Gly Asp Leu Ser Thr Thr Asn Asn Ala Thr Lys Lys Lys Ala Asn 
        835                 840                 845             
Ser Arg Ser Met Asp Trp Leu Ala Arg Gly Val Phe Asn Lys Ile Arg 
    850                 855                 860                 
Gln Leu Ala Pro Met His Asn Ile Thr Leu Phe Gly Cys Gly Ser Leu 
865                 870                 875                 880 
Tyr Thr Ser His Gln Asp Pro Leu Val His Arg Asn Pro Asp Lys Ala 
                885                 890                 895     
Met Lys Cys Arg Trp Ala Ala Ile Pro Val Lys Asp Ile Gly Asp Trp 
            900                 905                 910         
Val Leu Arg Lys Leu Ser Gln Asn Leu Arg Ala Lys Asn Ile Gly Thr 
        915                 920                 925             
Gly Glu Tyr Tyr His Gln Gly Val Lys Glu Phe Leu Ser His Tyr Glu 
    930                 935                 940                 
Leu Gln Asp Leu Glu Glu Glu Leu Leu Lys Trp Arg Ser Asp Arg Lys 
945                 950                 955                 960 
Ser Asn Ile Pro Cys Trp Val Leu Gln Asn Arg Leu Ala Glu Lys Leu 
                965                 970                 975     
Gly Asn Lys Glu Ala Val Val Tyr Ile Pro Val Arg Gly Gly Arg Ile 
            980                 985                 990         
Tyr Phe Ala Thr His Lys Val Ala  Thr Gly Ala Val Ser  Ile Val Phe 
        995                 1000                 1005             
Asp Gln  Lys Gln Val Trp Val  Cys Asn Ala Asp His  Val Ala Ala Ala 
    1010                 1015                 1020                 
Asn  Ile Ala Leu Thr Val  Lys Gly Ile Gly Glu  Gln Ser Ser Asp Glu  
1025                 1030                 1035                 1040 
Glu Asn Pro Asp Gly  Ser Arg Ile Lys Leu  Gln Leu Thr Ser 
                1045                 1050                 

<210>  19
<211>  1054
<212>  PRT
<213>  Artificial Sequence

<400>  19
Met Ser Ser Ala Ile Lys Ser Tyr Lys Ser Val Leu Arg Pro Asn Glu 
1               5                   10                  15      
Arg Lys Asn Gln Leu Leu Lys Ser Thr Ile Gln Cys Leu Glu Asp Gly 
            20                  25                  30          
Ser Ala Phe Phe Phe Lys Met Leu Gln Gly Leu Phe Gly Gly Ile Thr 
        35                  40                  45              
Pro Glu Ile Val Arg Phe Ser Thr Glu Gln Glu Lys Gln Gln Gln Asp 
    50                  55                  60                  
Ile Ala Leu Trp Cys Ala Val Asn Trp Phe Arg Pro Val Ser Gln Asp 
65                  70                  75                  80  
Ser Leu Thr His Thr Ile Ala Ser Asp Asn Leu Val Glu Lys Phe Glu 
                85                  90                  95      
Glu Tyr Tyr Gly Gly Thr Ala Ser Asp Ala Ile Lys Gln Tyr Phe Ser 
            100                 105                 110         
Ala Ser Ile Gly Glu Ser Tyr Tyr Trp Asn Asp Cys Arg Gln Gln Tyr 
        115                 120                 125             
Tyr Asp Leu Cys Arg Glu Leu Gly Val Glu Val Ser Asp Leu Thr His 
    130                 135                 140                 
Asp Leu Glu Ile Leu Cys Arg Glu Lys Cys Leu Ala Val Ala Thr Glu 
145                 150                 155                 160 
Ser Asn Gln Tyr Asn Ser Ile Ile Ser Val Leu Phe Gly Thr Gly Arg 
                165                 170                 175     
Lys Glu Asp Arg Ser Val Lys Leu Arg Ile Thr Lys Lys Ile Leu Glu 
            180                 185                 190         
Ala Ile Ser Asn Leu Lys Glu Ile Pro Lys Asn Val Ala Pro Ile Gln 
        195                 200                 205             
Glu Ile Ile Leu Asn Val Ala Lys Ala Thr Lys Glu Thr Phe Arg Gln 
    210                 215                 220                 
Val Tyr Ala Gly Asn Leu Gly Ala Pro Ser Thr Leu Glu Arg Phe Ile 
225                 230                 235                 240 
Ala Lys Asp Gly Gln Lys Glu Phe Asp Leu Lys Lys Leu Gln Thr Asp 
                245                 250                 255     
Leu Lys Lys Val Ile Arg Gly Lys Ser Lys Glu Arg Asp Trp Cys Cys 
            260                 265                 270         
Gln Glu Glu Leu Arg Ser Tyr Val Glu Gln Asn Thr Ile Gln Tyr Asp 
        275                 280                 285             
Leu Trp Ala Trp Gly Glu Met Phe Asn Lys Ala His Thr Ala Leu Lys 
    290                 295                 300                 
Ile Lys Ser Thr Arg Asn Tyr Asn Phe Ala Lys Gln Arg Leu Glu Gln 
305                 310                 315                 320 
Phe Lys Arg Ile Gln Ser Leu Asn Asn Leu Leu Val Val Lys Lys Leu 
                325                 330                 335     
Asn Asp Phe Phe Asp Ser Glu Phe Phe Ser Gly Glu Glu Thr Tyr Thr 
            340                 345                 350         
Ile Cys Val His His Leu Gly Gly Lys Arg Leu Ser Lys Leu Tyr Lys 
        355                 360                 365             
Ala Trp Glu Asp Asp Pro Ala Asp Pro Glu Asn Ala Ile Val Val Leu 
    370                 375                 380                 
Cys Asp Asp Leu Lys Asn Asn Phe Lys Lys Glu Pro Ile Arg Asn Ile 
385                 390                 395                 400 
Leu Arg Tyr Ile Phe Thr Ile Arg Gln Glu Cys Ser Ala Gln Asp Ile 
                405                 410                 415     
Leu Ala Ala Ala Lys Tyr Asn Gln Gln Leu Asp Arg Tyr Lys Ser Gln 
            420                 425                 430         
Lys Ala Asn Pro Ser Val Leu Gly Asn Gln Gly Phe Thr Trp Arg Asn 
        435                 440                 445             
Ala Val Ile Leu Pro Glu Lys Ala Gln Arg Asn Asp Arg Pro Asn Ser 
    450                 455                 460                 
Leu Asp Leu Arg Ile Trp Leu Tyr Leu Lys Leu Arg His Pro Asp Gly 
465                 470                 475                 480 
Arg Trp Lys Lys His His Ile Pro Phe Tyr Asp Thr Arg Phe Phe Gln 
                485                 490                 495     
Glu Ile Tyr Ala Ala Gly Asn Ser Pro Val Asp Thr Cys Gln Phe Arg 
            500                 505                 510         
Thr Pro Arg Phe Gly Tyr His Leu Pro Lys Leu Thr Asp Gln Thr Ala 
        515                 520                 525             
Ile Arg Val Asn Lys Lys His Val Lys Ala Ala Lys Thr Glu Ala Arg 
    530                 535                 540                 
Ile Arg Leu Ala Ile Gln Gln Gly Thr Leu Pro Val Ser Asn Leu Lys 
545                 550                 555                 560 
Ile Thr Arg Ile Ser Ala Thr Ile Asn Ser Lys Gly Gln Val Arg Ile 
                565                 570                 575     
Pro Val Lys Phe Asp Val Gly Arg Gln Lys Gly Thr Leu Gln Ile Gly 
            580                 585                 590         
Asp Arg Phe Cys Gly Tyr Asp Gln Asn Gln Thr Ala Ser His Ala Tyr 
        595                 600                 605             
Ser Leu Trp Glu Val Val Lys Glu Gly Gln Tyr His Lys Glu Leu Gly 
    610                 615                 620                 
Cys Phe Val Arg Phe Ile Ser Ser Gly Asp Ile Val Ser Ile Thr Glu 
625                 630                 635                 640 
Asn Arg Gly Asn Gln Phe Asp Gln Leu Ser Tyr Glu Gly Leu Ala Tyr 
                645                 650                 655     
Pro Gln Tyr Ala Asp Trp Arg Lys Lys Ala Ser Lys Phe Val Ser Leu 
            660                 665                 670         
Trp Gln Ile Thr Lys Lys Asn Lys Lys Lys Glu Ile Val Thr Val Glu 
        675                 680                 685             
Ala Lys Glu Lys Phe Asp Ala Ile Cys Lys Tyr Gln Pro Arg Leu Tyr 
    690                 695                 700                 
Lys Phe Asn Lys Glu Tyr Ala Tyr Leu Leu Arg Asp Ile Val Ala Gly 
705                 710                 715                 720 
Lys Ser Leu Val Glu Leu Gln Gln Ile Arg Gln Glu Ile Phe Arg Phe 
                725                 730                 735     
Ile Glu Gln Asp Cys Gly Val Thr Arg Leu Gly Ser Leu Ser Leu Ser 
            740                 745                 750         
Thr Leu Glu Thr Val Lys Ala Val Lys Gly Ile Ile Tyr Ser Tyr Phe 
        755                 760                 765             
Ser Thr Ala Leu Asn Ala Ser Lys Asn Asn Pro Ile Ser Asp Glu Gln 
    770                 775                 780                 
Arg Lys Glu Phe Asp Pro Glu Leu Phe Ala Leu Leu Glu Lys Leu Glu 
785                 790                 795                 800 
Leu Ile Arg Thr Arg Lys Lys Lys Gln Lys Val Glu Arg Ile Ala Asn 
                805                 810                 815     
Ser Leu Ile Gln Thr Cys Leu Glu Asn Asn Ile Lys Phe Ile Arg Gly 
            820                 825                 830         
Glu Gly Asp Leu Ser Thr Thr Asn Asn Ala Thr Lys Lys Lys Ala Asn 
        835                 840                 845             
Ser Arg Ser Met Asp Trp Leu Ala Arg Gly Val Phe Asn Lys Ile Arg 
    850                 855                 860                 
Gln Leu Ala Pro Met His Asn Ile Thr Leu Phe Gly Cys Gly Ser Leu 
865                 870                 875                 880 
Tyr Thr Ser His Gln Asp Pro Leu Val His Arg Asn Pro Asp Lys Ala 
                885                 890                 895     
Met Lys Cys Arg Trp Ala Ala Ile Pro Val Lys Asp Ile Gly Asp Trp 
            900                 905                 910         
Val Leu Arg Lys Leu Ser Gln Asn Leu Arg Ala Lys Asn Ile Gly Thr 
        915                 920                 925             
Gly Glu Tyr Tyr His Gln Gly Val Lys Glu Phe Leu Ser His Tyr Glu 
    930                 935                 940                 
Leu Gln Asp Leu Glu Glu Glu Leu Leu Lys Trp Arg Ser Asp Arg Lys 
945                 950                 955                 960 
Ser Asn Ile Pro Cys Trp Val Leu Gln Asn Arg Leu Ala Glu Lys Leu 
                965                 970                 975     
Gly Asn Lys Glu Ala Val Val Tyr Ile Pro Val Arg Gly Gly Arg Ile 
            980                 985                 990         
Tyr Phe Ala Thr His Lys Val Ala  Thr Gly Ala Val Ser  Ile Val Phe 
        995                 1000                 1005             
Asp Gln  Lys Gln Val Trp Val  Cys Asn Ala Asp His  Val Ala Ala Ala 
    1010                 1015                 1020                 
Asn  Ile Ala Leu Thr Val  Lys Gly Ile Gly Glu  Gln Ser Ser Asp Glu  
1025                 1030                 1035                 1040 
Glu Asn Pro Asp Gly  Ser Arg Ile Lys Leu  Gln Leu Thr Ser 
                1045                 1050                 

<210>  20
<211>  1054
<212>  PRT
<213>  Artificial Sequence

<400>  20
Met Ser Ser Ala Ile Lys Ser Tyr Lys Ser Val Leu Arg Pro Asn Glu 
1               5                   10                  15      
Arg Lys Asn Gln Leu Leu Lys Ser Thr Ile Gln Cys Leu Glu Asp Gly 
            20                  25                  30          
Ser Ala Phe Phe Phe Lys Met Leu Gln Gly Leu Phe Gly Gly Ile Thr 
        35                  40                  45              
Pro Glu Ile Val Arg Phe Ser Thr Glu Gln Glu Lys Gln Gln Gln Asp 
    50                  55                  60                  
Ile Ala Leu Trp Cys Ala Val Asn Trp Phe Arg Pro Val Ser Gln Asp 
65                  70                  75                  80  
Ser Leu Thr His Thr Ile Ala Ser Asp Asn Leu Val Glu Lys Phe Glu 
                85                  90                  95      
Glu Tyr Tyr Gly Gly Thr Ala Ser Asp Ala Ile Lys Gln Tyr Phe Ser 
            100                 105                 110         
Ala Ser Ile Gly Glu Ser Tyr Tyr Trp Asn Asp Cys Arg Gln Gln Tyr 
        115                 120                 125             
Tyr Asp Leu Cys Arg Glu Leu Gly Val Glu Val Ser Asp Leu Thr His 
    130                 135                 140                 
Asp Leu Glu Ile Leu Cys Arg Glu Lys Cys Leu Ala Val Ala Thr Glu 
145                 150                 155                 160 
Ser Asn Gln Tyr Asn Ser Ile Ile Ser Val Leu Phe Gly Thr Gly Arg 
                165                 170                 175     
Lys Glu Asp Arg Ser Val Lys Leu Arg Ile Thr Lys Lys Ile Leu Glu 
            180                 185                 190         
Ala Ile Ser Asn Leu Lys Glu Ile Pro Lys Asn Val Ala Pro Ile Gln 
        195                 200                 205             
Glu Ile Ile Leu Asn Val Ala Lys Ala Thr Lys Glu Thr Phe Arg Gln 
    210                 215                 220                 
Val Tyr Ala Gly Asn Leu Gly Ala Pro Ser Thr Leu Glu Arg Phe Ile 
225                 230                 235                 240 
Ala Lys Asp Gly Gln Lys Glu Phe Asp Leu Lys Lys Leu Gln Thr Asp 
                245                 250                 255     
Leu Lys Lys Val Ile Arg Gly Lys Ser Lys Glu Arg Asp Trp Cys Cys 
            260                 265                 270         
Gln Glu Glu Leu Arg Ser Tyr Val Glu Gln Asn Thr Ile Gln Tyr Asp 
        275                 280                 285             
Leu Trp Ala Trp Gly Glu Met Phe Asn Lys Ala His Thr Ala Leu Lys 
    290                 295                 300                 
Ile Lys Ser Thr Arg Asn Tyr Asn Phe Ala Lys Gln Arg Leu Glu Gln 
305                 310                 315                 320 
Phe Lys Arg Ile Gln Ser Leu Asn Asn Leu Leu Val Val Lys Lys Leu 
                325                 330                 335     
Asn Asp Phe Phe Asp Ser Glu Phe Phe Ser Gly Glu Glu Thr Tyr Thr 
            340                 345                 350         
Ile Cys Val His His Leu Gly Gly Lys Arg Leu Ser Lys Leu Tyr Lys 
        355                 360                 365             
Ala Trp Glu Asp Asp Pro Ala Asp Pro Glu Asn Ala Ile Val Val Leu 
    370                 375                 380                 
Cys Asp Asp Leu Lys Asn Asn Phe Lys Ala Glu Pro Ile Arg Asn Ile 
385                 390                 395                 400 
Leu Arg Tyr Ile Phe Thr Ile Arg Gln Glu Cys Ser Ala Gln Asp Ile 
                405                 410                 415     
Leu Ala Ala Ala Lys Tyr Asn Gln Gln Leu Asp Arg Tyr Lys Ser Gln 
            420                 425                 430         
Lys Ala Asn Pro Ser Val Leu Gly Asn Gln Gly Phe Thr Trp Arg Asn 
        435                 440                 445             
Ala Val Ile Leu Pro Glu Lys Ala Gln Arg Asn Asp Arg Pro Asn Ser 
    450                 455                 460                 
Leu Asp Leu Arg Ile Trp Leu Tyr Leu Lys Leu Arg His Pro Asp Gly 
465                 470                 475                 480 
Arg Trp Lys Lys His His Ile Pro Phe Tyr Asp Thr Arg Phe Phe Gln 
                485                 490                 495     
Glu Ile Tyr Ala Ala Gly Asn Ser Pro Val Asp Thr Cys Gln Phe Arg 
            500                 505                 510         
Thr Pro Arg Phe Gly Tyr His Leu Pro Lys Leu Thr Asp Gln Thr Ala 
        515                 520                 525             
Ile Arg Val Asn Lys Lys His Val Lys Ala Ala Lys Thr Glu Ala Arg 
    530                 535                 540                 
Ile Arg Leu Ala Ile Gln Gln Gly Thr Leu Pro Val Ser Asn Leu Lys 
545                 550                 555                 560 
Ile Thr Arg Ile Ser Ala Thr Ile Asn Ser Lys Gly Gln Val Arg Ile 
                565                 570                 575     
Pro Val Lys Phe Asp Val Gly Arg Gln Lys Gly Thr Leu Gln Ile Gly 
            580                 585                 590         
Asp Arg Phe Cys Gly Tyr Asp Gln Asn Gln Thr Ala Ser His Ala Tyr 
        595                 600                 605             
Ser Leu Trp Glu Val Val Lys Glu Gly Gln Tyr His Lys Glu Leu Gly 
    610                 615                 620                 
Cys Phe Val Arg Phe Ile Ser Ser Gly Asp Ile Val Ser Ile Thr Glu 
625                 630                 635                 640 
Asn Arg Gly Asn Gln Phe Asp Gln Leu Ser Tyr Glu Gly Leu Ala Tyr 
                645                 650                 655     
Pro Gln Tyr Ala Asp Trp Arg Lys Lys Ala Ser Lys Phe Val Ser Leu 
            660                 665                 670         
Trp Gln Ile Thr Lys Lys Asn Lys Lys Lys Glu Ile Val Thr Val Glu 
        675                 680                 685             
Ala Lys Glu Lys Phe Asp Ala Ile Cys Lys Tyr Gln Pro Arg Leu Tyr 
    690                 695                 700                 
Lys Phe Asn Lys Glu Tyr Ala Tyr Leu Leu Arg Asp Ile Val Arg Gly 
705                 710                 715                 720 
Lys Ser Leu Val Glu Leu Gln Gln Ile Arg Gln Glu Ile Phe Arg Phe 
                725                 730                 735     
Ile Glu Gln Asp Cys Gly Val Thr Arg Leu Gly Ser Leu Ser Leu Ser 
            740                 745                 750         
Thr Leu Glu Thr Val Lys Ala Val Lys Gly Ile Ile Tyr Ser Tyr Phe 
        755                 760                 765             
Ser Thr Ala Leu Asn Ala Ser Lys Asn Asn Pro Ile Ser Asp Glu Gln 
    770                 775                 780                 
Arg Lys Glu Phe Asp Pro Glu Leu Phe Ala Leu Leu Glu Lys Leu Glu 
785                 790                 795                 800 
Leu Ile Arg Thr Arg Lys Lys Lys Gln Lys Val Glu Arg Ile Ala Asn 
                805                 810                 815     
Ser Leu Ile Gln Thr Cys Leu Glu Asn Asn Ile Lys Phe Ile Arg Gly 
            820                 825                 830         
Glu Gly Asp Leu Ser Thr Thr Asn Asn Ala Thr Lys Lys Lys Ala Asn 
        835                 840                 845             
Ser Arg Ser Met Asp Trp Leu Ala Arg Gly Val Phe Asn Lys Ile Arg 
    850                 855                 860                 
Gln Leu Ala Pro Met His Asn Ile Thr Leu Phe Gly Cys Gly Ser Leu 
865                 870                 875                 880 
Tyr Thr Ser His Gln Asp Pro Leu Val His Arg Asn Pro Asp Lys Ala 
                885                 890                 895     
Met Lys Cys Arg Trp Ala Ala Ile Pro Val Lys Asp Ile Gly Asp Trp 
            900                 905                 910         
Val Leu Arg Lys Leu Ser Gln Asn Leu Arg Ala Lys Asn Ile Gly Thr 
        915                 920                 925             
Gly Glu Tyr Tyr His Gln Gly Val Lys Glu Phe Leu Ser His Tyr Glu 
    930                 935                 940                 
Leu Gln Asp Leu Glu Glu Glu Leu Leu Lys Trp Arg Ser Asp Arg Lys 
945                 950                 955                 960 
Ser Asn Ile Pro Cys Trp Val Leu Gln Asn Arg Leu Ala Glu Lys Leu 
                965                 970                 975     
Gly Asn Lys Glu Ala Val Val Tyr Ile Pro Val Arg Gly Gly Arg Ile 
            980                 985                 990         
Tyr Phe Ala Thr His Lys Val Ala  Thr Gly Ala Val Ser  Ile Val Phe 
        995                 1000                 1005             
Asp Gln  Lys Gln Val Trp Val  Cys Asn Ala Asp His  Val Ala Ala Ala 
    1010                 1015                 1020                 
Asn  Ile Ala Leu Thr Val  Lys Gly Ile Gly Glu  Gln Ser Ser Asp Glu  
1025                 1030                 1035                 1040 
Glu Asn Pro Asp Gly  Ser Arg Ile Lys Leu  Gln Leu Thr Ser 
                1045                 1050                 

<210>  21
<211>  1054
<212>  PRT
<213>  Artificial Sequence

<400>  21
Met Ser Ser Ala Ile Lys Ser Tyr Lys Ser Val Leu Arg Pro Asn Glu 
1               5                   10                  15      
Arg Lys Asn Gln Leu Leu Lys Ser Thr Ile Gln Cys Leu Glu Asp Gly 
            20                  25                  30          
Ser Ala Phe Phe Phe Lys Met Leu Gln Gly Leu Phe Gly Gly Ile Thr 
        35                  40                  45              
Pro Glu Ile Val Arg Phe Ser Thr Glu Gln Glu Lys Gln Gln Gln Asp 
    50                  55                  60                  
Ile Ala Leu Trp Cys Ala Val Asn Trp Phe Arg Pro Val Ser Gln Asp 
65                  70                  75                  80  
Ser Leu Thr His Thr Ile Ala Ser Asp Asn Leu Val Glu Lys Phe Glu 
                85                  90                  95      
Glu Tyr Tyr Gly Gly Thr Ala Ser Asp Ala Ile Lys Gln Tyr Phe Ser 
            100                 105                 110         
Ala Ser Ile Gly Glu Ser Tyr Tyr Trp Asn Asp Cys Arg Gln Gln Tyr 
        115                 120                 125             
Tyr Asp Leu Cys Arg Glu Leu Gly Val Glu Val Ser Asp Leu Thr His 
    130                 135                 140                 
Asp Leu Glu Ile Leu Cys Arg Glu Lys Cys Leu Ala Val Ala Thr Glu 
145                 150                 155                 160 
Ser Asn Gln Tyr Asn Ser Ile Ile Ser Val Leu Phe Gly Thr Gly Arg 
                165                 170                 175     
Lys Glu Asp Arg Ser Val Lys Leu Arg Ile Thr Lys Lys Ile Leu Glu 
            180                 185                 190         
Ala Ile Ser Asn Leu Lys Glu Ile Pro Lys Asn Val Ala Pro Ile Gln 
        195                 200                 205             
Glu Ile Ile Leu Asn Val Ala Lys Ala Thr Lys Glu Thr Phe Arg Gln 
    210                 215                 220                 
Val Tyr Ala Gly Asn Leu Gly Ala Pro Ser Thr Leu Glu Arg Phe Ile 
225                 230                 235                 240 
Ala Lys Asp Gly Gln Lys Glu Phe Asp Leu Lys Lys Leu Gln Thr Asp 
                245                 250                 255     
Leu Lys Lys Val Ile Arg Gly Lys Ser Lys Glu Arg Asp Trp Cys Cys 
            260                 265                 270         
Gln Glu Glu Leu Arg Ser Tyr Val Glu Gln Asn Thr Ile Gln Tyr Asp 
        275                 280                 285             
Leu Trp Ala Trp Gly Glu Met Phe Asn Lys Ala His Thr Ala Leu Lys 
    290                 295                 300                 
Ile Lys Ser Thr Arg Asn Tyr Asn Phe Ala Lys Gln Arg Leu Glu Gln 
305                 310                 315                 320 
Phe Lys Arg Ile Gln Ser Leu Asn Asn Leu Leu Val Val Lys Lys Leu 
                325                 330                 335     
Asn Asp Phe Phe Asp Ser Glu Phe Phe Ser Gly Glu Glu Thr Tyr Thr 
            340                 345                 350         
Ile Cys Val His Ala Leu Gly Gly Lys Arg Leu Ser Lys Leu Tyr Lys 
        355                 360                 365             
Ala Trp Glu Asp Asp Pro Ala Asp Pro Glu Asn Ala Ile Val Val Leu 
    370                 375                 380                 
Cys Asp Asp Leu Lys Asn Asn Phe Lys Lys Glu Pro Ile Arg Asn Ile 
385                 390                 395                 400 
Leu Arg Tyr Ile Phe Thr Ile Arg Gln Glu Cys Ser Ala Gln Asp Ile 
                405                 410                 415     
Leu Ala Ala Ala Lys Tyr Asn Gln Gln Leu Asp Arg Tyr Lys Ser Gln 
            420                 425                 430         
Lys Ala Asn Pro Ser Val Leu Gly Asn Gln Gly Phe Thr Trp Arg Asn 
        435                 440                 445             
Ala Val Ile Leu Pro Glu Lys Ala Gln Arg Asn Asp Arg Pro Asn Ser 
    450                 455                 460                 
Leu Asp Leu Arg Ile Trp Leu Tyr Leu Lys Leu Arg His Pro Asp Gly 
465                 470                 475                 480 
Arg Trp Lys Lys His His Ile Pro Phe Tyr Asp Thr Arg Phe Phe Gln 
                485                 490                 495     
Glu Ile Tyr Ala Ala Gly Asn Ser Pro Val Asp Thr Cys Gln Phe Arg 
            500                 505                 510         
Thr Pro Arg Phe Gly Tyr His Leu Pro Lys Leu Thr Asp Gln Thr Ala 
        515                 520                 525             
Ile Arg Val Asn Lys Lys His Val Lys Ala Ala Lys Thr Glu Ala Arg 
    530                 535                 540                 
Ile Arg Leu Ala Ile Gln Gln Gly Thr Leu Pro Val Ser Asn Leu Lys 
545                 550                 555                 560 
Ile Thr Arg Ile Ser Ala Thr Ile Asn Ser Lys Gly Gln Val Arg Ile 
                565                 570                 575     
Pro Val Lys Phe Asp Val Gly Arg Gln Lys Gly Thr Leu Gln Ile Gly 
            580                 585                 590         
Asp Arg Phe Cys Gly Tyr Asp Gln Asn Gln Thr Ala Ser His Ala Tyr 
        595                 600                 605             
Ser Leu Trp Glu Val Val Lys Glu Gly Gln Tyr His Lys Glu Leu Gly 
    610                 615                 620                 
Cys Phe Val Arg Phe Ile Ser Ser Gly Asp Ile Val Ser Ile Thr Glu 
625                 630                 635                 640 
Asn Arg Gly Asn Gln Phe Asp Gln Leu Ser Tyr Glu Gly Leu Ala Tyr 
                645                 650                 655     
Pro Gln Tyr Ala Asp Trp Arg Lys Lys Ala Ser Lys Phe Val Ser Leu 
            660                 665                 670         
Trp Gln Ile Thr Lys Lys Asn Lys Lys Lys Glu Ile Val Thr Val Glu 
        675                 680                 685             
Ala Lys Glu Lys Phe Asp Ala Ile Cys Lys Tyr Gln Pro Arg Leu Tyr 
    690                 695                 700                 
Lys Phe Asn Lys Glu Tyr Ala Tyr Leu Leu Arg Asp Ile Val Arg Gly 
705                 710                 715                 720 
Lys Ser Leu Val Glu Leu Gln Gln Ile Arg Gln Glu Ile Phe Arg Phe 
                725                 730                 735     
Ile Glu Gln Asp Cys Gly Val Thr Arg Leu Gly Ser Leu Ser Leu Ser 
            740                 745                 750         
Thr Leu Glu Thr Val Lys Ala Val Lys Gly Ile Ile Tyr Ser Tyr Phe 
        755                 760                 765             
Ser Thr Ala Leu Asn Ala Ser Lys Asn Asn Pro Ile Ser Asp Glu Gln 
    770                 775                 780                 
Arg Lys Glu Phe Asp Pro Glu Leu Phe Ala Leu Leu Glu Lys Leu Glu 
785                 790                 795                 800 
Leu Ile Arg Thr Arg Lys Lys Lys Gln Lys Val Glu Arg Ile Ala Asn 
                805                 810                 815     
Ser Leu Ile Gln Thr Cys Leu Glu Asn Asn Ile Lys Phe Ile Arg Gly 
            820                 825                 830         
Glu Gly Asp Leu Ser Thr Thr Asn Asn Ala Thr Lys Lys Lys Ala Asn 
        835                 840                 845             
Ser Arg Ser Met Asp Trp Leu Ala Arg Gly Val Phe Asn Lys Ile Arg 
    850                 855                 860                 
Gln Leu Ala Pro Met His Asn Ile Thr Leu Phe Gly Cys Gly Ser Leu 
865                 870                 875                 880 
Tyr Thr Ser His Gln Asp Pro Leu Val His Arg Asn Pro Asp Lys Ala 
                885                 890                 895     
Met Lys Cys Arg Trp Ala Ala Ile Pro Val Lys Asp Ile Gly Asp Trp 
            900                 905                 910         
Val Leu Arg Lys Leu Ser Gln Asn Leu Arg Ala Lys Asn Ile Gly Thr 
        915                 920                 925             
Gly Glu Tyr Tyr His Gln Gly Val Lys Glu Phe Leu Ser His Tyr Glu 
    930                 935                 940                 
Leu Gln Asp Leu Glu Glu Glu Leu Leu Lys Trp Arg Ser Asp Arg Lys 
945                 950                 955                 960 
Ser Asn Ile Pro Cys Trp Val Leu Gln Asn Arg Leu Ala Glu Lys Leu 
                965                 970                 975     
Gly Asn Lys Glu Ala Val Val Tyr Ile Pro Val Arg Gly Gly Arg Ile 
            980                 985                 990         
Tyr Phe Ala Thr His Lys Val Ala  Thr Gly Ala Val Ser  Ile Val Phe 
        995                 1000                 1005             
Asp Gln  Lys Gln Val Trp Val  Cys Asn Ala Asp His  Val Ala Ala Ala 
    1010                 1015                 1020                 
Asn  Ile Ala Leu Thr Val  Lys Gly Ile Gly Glu  Gln Ser Ser Asp Glu  
1025                 1030                 1035                 1040 
Glu Asn Pro Asp Gly  Ser Arg Ile Lys Leu  Gln Leu Thr Ser 
                1045                 1050                 

<210>  22
<211>  1054
<212>  PRT
<213>  Artificial Sequence

<400>  22
Met Ser Ser Ala Ile Lys Ser Tyr Lys Ser Val Leu Arg Pro Asn Glu 
1               5                   10                  15      
Arg Lys Asn Gln Leu Leu Lys Ser Thr Ile Gln Cys Leu Glu Asp Gly 
            20                  25                  30          
Ser Ala Phe Phe Phe Lys Met Leu Gln Gly Leu Phe Gly Gly Ile Thr 
        35                  40                  45              
Pro Glu Ile Val Arg Phe Ser Thr Glu Gln Glu Lys Gln Gln Gln Asp 
    50                  55                  60                  
Ile Ala Leu Trp Cys Ala Val Asn Trp Phe Arg Pro Val Ser Gln Asp 
65                  70                  75                  80  
Ser Leu Thr His Thr Ile Ala Ser Asp Asn Leu Val Glu Lys Phe Glu 
                85                  90                  95      
Glu Tyr Tyr Gly Gly Thr Ala Ser Asp Ala Ile Lys Gln Tyr Phe Ser 
            100                 105                 110         
Ala Ser Ile Gly Glu Ser Tyr Tyr Trp Asn Asp Cys Arg Gln Gln Tyr 
        115                 120                 125             
Tyr Asp Leu Cys Arg Glu Leu Gly Val Glu Val Ser Asp Leu Thr His 
    130                 135                 140                 
Asp Leu Glu Ile Leu Cys Arg Glu Lys Cys Leu Ala Val Ala Thr Glu 
145                 150                 155                 160 
Ser Asn Gln Tyr Asn Ser Ile Ile Ser Val Leu Phe Gly Thr Gly Arg 
                165                 170                 175     
Lys Glu Asp Arg Ser Val Lys Leu Arg Ile Thr Lys Lys Ile Leu Glu 
            180                 185                 190         
Ala Ile Ser Asn Leu Lys Glu Ile Pro Lys Asn Val Ala Pro Ile Gln 
        195                 200                 205             
Glu Ile Ile Leu Asn Val Ala Lys Ala Thr Lys Glu Thr Phe Arg Gln 
    210                 215                 220                 
Val Tyr Ala Gly Asn Leu Gly Ala Pro Ser Thr Leu Glu Arg Phe Ile 
225                 230                 235                 240 
Ala Lys Asp Gly Gln Lys Glu Phe Asp Leu Lys Lys Leu Gln Thr Asp 
                245                 250                 255     
Leu Lys Lys Val Ile Arg Gly Lys Ser Lys Glu Arg Asp Trp Cys Cys 
            260                 265                 270         
Gln Glu Glu Leu Arg Ser Tyr Val Glu Gln Asn Thr Ile Gln Tyr Asp 
        275                 280                 285             
Leu Trp Ala Trp Gly Glu Met Phe Asn Lys Ala His Thr Ala Leu Lys 
    290                 295                 300                 
Ile Lys Ser Thr Arg Asn Tyr Asn Phe Ala Lys Gln Arg Leu Glu Gln 
305                 310                 315                 320 
Phe Lys Arg Ile Gln Ser Leu Asn Asn Leu Leu Val Val Lys Lys Leu 
                325                 330                 335     
Asn Asp Phe Phe Asp Ser Glu Phe Phe Ser Gly Glu Glu Thr Tyr Thr 
            340                 345                 350         
Ile Cys Val His His Leu Gly Gly Lys Arg Leu Ser Lys Leu Tyr Lys 
        355                 360                 365             
Ala Trp Glu Asp Asp Pro Ala Asp Pro Glu Asn Ala Ile Val Val Leu 
    370                 375                 380                 
Cys Asp Asp Leu Lys Asn Asn Phe Lys Lys Glu Pro Ile Arg Asn Ile 
385                 390                 395                 400 
Leu Arg Tyr Ile Phe Thr Ile Arg Gln Glu Cys Ser Ala Gln Asp Ile 
                405                 410                 415     
Leu Ala Ala Ala Lys Tyr Asn Gln Gln Leu Asp Arg Tyr Lys Ser Gln 
            420                 425                 430         
Lys Ala Asn Pro Ser Val Leu Gly Asn Gln Gly Phe Thr Trp Arg Asn 
        435                 440                 445             
Ala Val Ile Leu Pro Glu Lys Ala Gln Arg Asn Asp Arg Pro Asn Ser 
    450                 455                 460                 
Leu Asp Leu Arg Ile Trp Leu Tyr Leu Lys Leu Arg His Pro Asp Gly 
465                 470                 475                 480 
Arg Trp Lys Lys His His Ile Pro Phe Tyr Asp Thr Arg Phe Phe Gln 
                485                 490                 495     
Glu Ile Tyr Ala Ala Gly Asn Ser Pro Val Asp Thr Cys Gln Phe Arg 
            500                 505                 510         
Thr Pro Arg Phe Gly Tyr His Leu Pro Lys Leu Thr Asp Gln Thr Ala 
        515                 520                 525             
Ile Arg Val Asn Lys Lys His Val Lys Ala Ala Lys Thr Glu Ala Arg 
    530                 535                 540                 
Ile Arg Leu Ala Ile Gln Gln Gly Thr Leu Pro Val Ser Asn Leu Lys 
545                 550                 555                 560 
Ile Thr Arg Ile Ser Ala Thr Ile Asn Ser Lys Gly Gln Val Arg Ile 
                565                 570                 575     
Pro Val Lys Phe Asp Val Gly Arg Gln Lys Gly Thr Leu Gln Ile Gly 
            580                 585                 590         
Asp Arg Phe Cys Gly Tyr Asp Gln Asn Gln Thr Ala Ser His Ala Tyr 
        595                 600                 605             
Ser Leu Trp Glu Val Val Lys Glu Gly Gln Tyr His Lys Glu Leu Gly 
    610                 615                 620                 
Cys Phe Val Arg Phe Ile Ser Ser Gly Asp Ile Val Ser Ile Thr Glu 
625                 630                 635                 640 
Asn Arg Gly Asn Gln Phe Asp Gln Leu Ser Tyr Glu Gly Leu Ala Tyr 
                645                 650                 655     
Pro Gln Tyr Ala Asp Trp Arg Lys Lys Ala Ser Lys Phe Val Ser Leu 
            660                 665                 670         
Trp Gln Ile Thr Lys Lys Asn Lys Lys Lys Glu Ile Val Thr Val Glu 
        675                 680                 685             
Ala Lys Glu Lys Phe Asp Ala Ile Cys Lys Tyr Gln Pro Arg Leu Tyr 
    690                 695                 700                 
Lys Phe Asn Lys Glu Tyr Ala Tyr Leu Leu Arg Asp Ile Val Arg Gly 
705                 710                 715                 720 
Lys Ser Leu Val Glu Leu Gln Gln Ile Arg Gln Glu Ile Phe Arg Phe 
                725                 730                 735     
Ile Glu Gln Asp Cys Gly Val Thr Arg Leu Gly Ser Leu Ser Leu Ser 
            740                 745                 750         
Thr Leu Glu Thr Val Lys Ala Val Lys Gly Ile Ile Tyr Ser Tyr Phe 
        755                 760                 765             
Ser Thr Ala Leu Asn Ala Ser Lys Asn Asn Pro Ile Ser Asp Glu Gln 
    770                 775                 780                 
Arg Lys Glu Phe Asp Pro Glu Leu Phe Ala Leu Leu Glu Lys Leu Glu 
785                 790                 795                 800 
Leu Ile Arg Thr Arg Lys Lys Lys Gln Lys Val Glu Arg Ile Ala Asn 
                805                 810                 815     
Ser Leu Ile Gln Thr Cys Leu Glu Asn Asn Ile Lys Phe Ile Arg Gly 
            820                 825                 830         
Glu Gly Asp Leu Ser Thr Thr Asn Asn Ala Thr Ala Lys Lys Ala Asn 
        835                 840                 845             
Ser Arg Ser Met Asp Trp Leu Ala Arg Gly Val Phe Asn Lys Ile Arg 
    850                 855                 860                 
Gln Leu Ala Pro Met His Asn Ile Thr Leu Phe Gly Cys Gly Ser Leu 
865                 870                 875                 880 
Tyr Thr Ser His Gln Asp Pro Leu Val His Arg Asn Pro Asp Lys Ala 
                885                 890                 895     
Met Lys Cys Arg Trp Ala Ala Ile Pro Val Lys Asp Ile Gly Asp Trp 
            900                 905                 910         
Val Leu Arg Lys Leu Ser Gln Asn Leu Arg Ala Lys Asn Ile Gly Thr 
        915                 920                 925             
Gly Glu Tyr Tyr His Gln Gly Val Lys Glu Phe Leu Ser His Tyr Glu 
    930                 935                 940                 
Leu Gln Asp Leu Glu Glu Glu Leu Leu Lys Trp Arg Ser Asp Arg Lys 
945                 950                 955                 960 
Ser Asn Ile Pro Cys Trp Val Leu Gln Asn Arg Leu Ala Glu Lys Leu 
                965                 970                 975     
Gly Asn Lys Glu Ala Val Val Tyr Ile Pro Val Arg Gly Gly Arg Ile 
            980                 985                 990         
Tyr Phe Ala Thr His Lys Val Ala  Thr Gly Ala Val Ser  Ile Val Phe 
        995                 1000                 1005             
Asp Gln  Lys Gln Val Trp Val  Cys Asn Ala Asp His  Val Ala Ala Ala 
    1010                 1015                 1020                 
Asn  Ile Ala Leu Thr Val  Lys Gly Ile Gly Glu  Gln Ser Ser Asp Glu  
1025                 1030                 1035                 1040 
Glu Asn Pro Asp Gly  Ser Arg Ile Lys Leu  Gln Leu Thr Ser 
                1045                 1050                 

<210>  23
<211>  1054
<212>  PRT
<213>  Artificial Sequence

<400>  23
Met Ser Ser Ala Ile Lys Ser Tyr Lys Ser Val Leu Arg Pro Asn Glu 
1               5                   10                  15      
Arg Lys Asn Gln Leu Leu Lys Ser Thr Ile Gln Cys Leu Glu Asp Gly 
            20                  25                  30          
Ser Ala Phe Phe Phe Lys Met Leu Gln Gly Leu Phe Gly Gly Ile Thr 
        35                  40                  45              
Pro Glu Ile Val Arg Phe Ser Thr Glu Gln Glu Lys Gln Gln Gln Asp 
    50                  55                  60                  
Ile Ala Leu Trp Cys Ala Val Asn Trp Phe Arg Pro Val Ser Gln Asp 
65                  70                  75                  80  
Ser Leu Thr His Thr Ile Ala Ser Asp Asn Leu Val Glu Lys Phe Glu 
                85                  90                  95      
Glu Tyr Tyr Gly Gly Thr Ala Ser Asp Ala Ile Lys Gln Tyr Phe Ser 
            100                 105                 110         
Ala Ser Ile Gly Glu Ser Tyr Tyr Trp Asn Asp Cys Arg Gln Gln Tyr 
        115                 120                 125             
Tyr Asp Leu Cys Arg Glu Leu Gly Val Glu Val Ser Asp Leu Thr His 
    130                 135                 140                 
Asp Leu Glu Ile Leu Cys Arg Glu Lys Cys Leu Ala Val Ala Thr Glu 
145                 150                 155                 160 
Ser Asn Gln Tyr Asn Ser Ile Ile Ser Val Leu Phe Gly Thr Gly Arg 
                165                 170                 175     
Lys Glu Asp Arg Ser Val Lys Leu Arg Ile Thr Lys Lys Ile Leu Glu 
            180                 185                 190         
Ala Ile Ser Asn Leu Lys Glu Ile Pro Lys Asn Val Ala Pro Ile Gln 
        195                 200                 205             
Glu Ile Ile Leu Asn Val Ala Lys Ala Thr Lys Glu Thr Phe Arg Gln 
    210                 215                 220                 
Val Tyr Ala Gly Asn Leu Gly Ala Pro Ser Thr Leu Glu Arg Phe Ile 
225                 230                 235                 240 
Ala Lys Asp Gly Gln Lys Glu Phe Asp Leu Lys Lys Leu Gln Thr Asp 
                245                 250                 255     
Leu Lys Lys Val Ile Arg Gly Lys Ser Lys Glu Arg Asp Trp Cys Cys 
            260                 265                 270         
Gln Glu Glu Leu Arg Ser Tyr Val Glu Gln Asn Thr Ile Gln Tyr Asp 
        275                 280                 285             
Leu Trp Ala Trp Gly Glu Met Phe Asn Lys Ala His Thr Ala Leu Lys 
    290                 295                 300                 
Ile Lys Ser Thr Arg Asn Tyr Asn Phe Ala Lys Gln Arg Leu Glu Gln 
305                 310                 315                 320 
Phe Lys Arg Ile Gln Ser Leu Asn Asn Leu Leu Val Val Lys Lys Leu 
                325                 330                 335     
Asn Asp Phe Phe Asp Ser Glu Phe Phe Ser Gly Glu Glu Thr Tyr Thr 
            340                 345                 350         
Ile Cys Val His His Leu Gly Gly Lys Arg Leu Ser Lys Leu Tyr Lys 
        355                 360                 365             
Ala Trp Glu Asp Asp Pro Ala Asp Pro Glu Asn Ala Ile Val Val Leu 
    370                 375                 380                 
Cys Asp Asp Leu Lys Asn Asn Phe Lys Lys Glu Pro Ile Arg Asn Ile 
385                 390                 395                 400 
Leu Arg Tyr Ile Phe Thr Ile Arg Gln Glu Cys Ser Ala Gln Asp Ile 
                405                 410                 415     
Leu Ala Ala Ala Lys Tyr Asn Gln Gln Leu Asp Arg Tyr Lys Ser Gln 
            420                 425                 430         
Lys Ala Asn Pro Ser Val Leu Gly Asn Gln Gly Phe Thr Trp Arg Asn 
        435                 440                 445             
Ala Val Ile Leu Pro Glu Lys Ala Gln Arg Asn Asp Arg Pro Asn Ser 
    450                 455                 460                 
Leu Asp Leu Arg Ile Trp Leu Tyr Leu Lys Leu Arg His Pro Asp Gly 
465                 470                 475                 480 
Arg Trp Lys Lys His His Ile Pro Phe Tyr Asp Thr Arg Phe Phe Gln 
                485                 490                 495     
Glu Ile Tyr Ala Ala Gly Asn Ser Pro Val Asp Thr Cys Gln Phe Arg 
            500                 505                 510         
Thr Pro Arg Phe Gly Tyr His Leu Pro Lys Leu Thr Asp Gln Thr Ala 
        515                 520                 525             
Ile Arg Val Asn Lys Lys His Val Lys Ala Ala Lys Thr Glu Ala Arg 
    530                 535                 540                 
Ile Arg Leu Ala Ile Gln Gln Gly Thr Leu Pro Val Ser Asn Leu Lys 
545                 550                 555                 560 
Ile Thr Arg Ile Ser Ala Thr Ile Asn Ser Lys Gly Gln Val Arg Ile 
                565                 570                 575     
Pro Val Lys Phe Asp Val Gly Arg Gln Lys Gly Thr Leu Gln Ile Gly 
            580                 585                 590         
Asp Arg Phe Cys Gly Tyr Asp Gln Asn Gln Thr Ala Ser His Ala Tyr 
        595                 600                 605             
Ser Leu Trp Glu Val Val Lys Glu Gly Gln Tyr His Lys Glu Leu Gly 
    610                 615                 620                 
Cys Phe Val Arg Phe Ile Ser Ser Gly Asp Ile Val Ser Ile Thr Glu 
625                 630                 635                 640 
Asn Arg Gly Asn Gln Phe Asp Gln Leu Ser Tyr Glu Gly Leu Ala Tyr 
                645                 650                 655     
Pro Gln Tyr Ala Asp Trp Arg Lys Lys Ala Ser Lys Phe Val Ser Leu 
            660                 665                 670         
Trp Gln Ile Thr Lys Lys Asn Lys Lys Lys Glu Ile Val Thr Val Glu 
        675                 680                 685             
Ala Lys Glu Lys Phe Asp Ala Ile Cys Lys Tyr Gln Pro Arg Leu Tyr 
    690                 695                 700                 
Lys Phe Asn Lys Glu Tyr Ala Tyr Leu Leu Arg Asp Ile Val Ala Gly 
705                 710                 715                 720 
Lys Ser Leu Val Glu Leu Gln Gln Ile Arg Gln Glu Ile Phe Arg Phe 
                725                 730                 735     
Ile Glu Gln Asp Cys Gly Val Thr Arg Leu Gly Ser Leu Ser Leu Ser 
            740                 745                 750         
Thr Leu Glu Thr Val Lys Ala Val Lys Gly Ile Ile Tyr Ser Tyr Phe 
        755                 760                 765             
Ser Thr Ala Leu Asn Ala Ser Lys Asn Asn Pro Ile Ser Asp Glu Gln 
    770                 775                 780                 
Arg Lys Glu Phe Asp Pro Glu Leu Phe Ala Leu Leu Glu Lys Leu Glu 
785                 790                 795                 800 
Leu Ile Arg Thr Arg Lys Lys Lys Gln Lys Val Glu Arg Ile Ala Asn 
                805                 810                 815     
Ser Leu Ile Gln Thr Cys Leu Glu Asn Asn Ile Lys Phe Ile Arg Gly 
            820                 825                 830         
Glu Gly Asp Leu Ser Thr Thr Asn Asn Ala Thr Ala Lys Lys Ala Asn 
        835                 840                 845             
Ser Arg Ser Met Asp Trp Leu Ala Arg Gly Val Phe Asn Lys Ile Arg 
    850                 855                 860                 
Gln Leu Ala Pro Met His Asn Ile Thr Leu Phe Gly Cys Gly Ser Leu 
865                 870                 875                 880 
Tyr Thr Ser His Gln Asp Pro Leu Val His Arg Asn Pro Asp Lys Ala 
                885                 890                 895     
Met Lys Cys Arg Trp Ala Ala Ile Pro Val Lys Asp Ile Gly Asp Trp 
            900                 905                 910         
Val Leu Arg Lys Leu Ser Gln Asn Leu Arg Ala Lys Asn Ile Gly Thr 
        915                 920                 925             
Gly Glu Tyr Tyr His Gln Gly Val Lys Glu Phe Leu Ser His Tyr Glu 
    930                 935                 940                 
Leu Gln Asp Leu Glu Glu Glu Leu Leu Lys Trp Arg Ser Asp Arg Lys 
945                 950                 955                 960 
Ser Asn Ile Pro Cys Trp Val Leu Gln Asn Arg Leu Ala Glu Lys Leu 
                965                 970                 975     
Gly Asn Lys Glu Ala Val Val Tyr Ile Pro Val Arg Gly Gly Arg Ile 
            980                 985                 990         
Tyr Phe Ala Thr His Lys Val Ala  Thr Gly Ala Val Ser  Ile Val Phe 
        995                 1000                 1005             
Asp Gln  Lys Gln Val Trp Val  Cys Asn Ala Asp His  Val Ala Ala Ala 
    1010                 1015                 1020                 
Asn  Ile Ala Leu Thr Val  Lys Gly Ile Gly Glu  Gln Ser Ser Asp Glu  
1025                 1030                 1035                 1040 
Glu Asn Pro Asp Gly  Ser Arg Ile Lys Leu  Gln Leu Thr Ser 
                1045                 1050                 

<210>  24
<211>  1054
<212>  PRT
<213>  Artificial Sequence

<400>  24
Met Ser Ser Ala Ile Lys Ser Tyr Lys Ser Val Leu Arg Pro Asn Glu 
1               5                   10                  15      
Arg Lys Asn Gln Leu Leu Lys Ser Thr Ile Gln Cys Leu Glu Asp Gly 
            20                  25                  30          
Ser Ala Phe Phe Phe Lys Met Leu Gln Gly Leu Phe Gly Gly Ile Thr 
        35                  40                  45              
Pro Glu Ile Val Arg Phe Ser Thr Glu Gln Glu Lys Gln Gln Gln Asp 
    50                  55                  60                  
Ile Ala Leu Trp Cys Ala Val Asn Trp Phe Arg Pro Val Ser Gln Asp 
65                  70                  75                  80  
Ser Leu Thr His Thr Ile Ala Ser Asp Asn Leu Val Glu Lys Phe Glu 
                85                  90                  95      
Glu Tyr Tyr Gly Gly Thr Ala Ser Asp Ala Ile Lys Gln Tyr Phe Ser 
            100                 105                 110         
Ala Ser Ile Gly Glu Ser Tyr Tyr Trp Asn Asp Cys Arg Gln Gln Tyr 
        115                 120                 125             
Tyr Asp Leu Cys Arg Glu Leu Gly Val Glu Val Ser Asp Leu Thr His 
    130                 135                 140                 
Asp Leu Glu Ile Leu Cys Arg Glu Lys Cys Leu Ala Val Ala Thr Glu 
145                 150                 155                 160 
Ser Asn Gln Tyr Asn Ser Ile Ile Ser Val Leu Phe Gly Thr Gly Arg 
                165                 170                 175     
Lys Glu Asp Arg Ser Val Lys Leu Arg Ile Thr Lys Lys Ile Leu Glu 
            180                 185                 190         
Ala Ile Ser Asn Leu Lys Glu Ile Pro Lys Asn Val Ala Pro Ile Gln 
        195                 200                 205             
Glu Ile Ile Leu Asn Val Ala Lys Ala Thr Lys Glu Thr Phe Arg Gln 
    210                 215                 220                 
Val Tyr Ala Gly Asn Leu Gly Ala Pro Ser Thr Leu Glu Arg Phe Ile 
225                 230                 235                 240 
Ala Lys Asp Gly Gln Lys Glu Phe Asp Leu Lys Lys Leu Gln Thr Asp 
                245                 250                 255     
Leu Lys Lys Val Ile Arg Gly Lys Ser Lys Glu Arg Asp Trp Cys Cys 
            260                 265                 270         
Gln Glu Glu Leu Arg Ser Tyr Val Glu Gln Asn Thr Ile Gln Tyr Asp 
        275                 280                 285             
Leu Trp Ala Trp Gly Glu Met Phe Asn Lys Ala His Thr Ala Leu Lys 
    290                 295                 300                 
Ile Lys Ser Thr Arg Asn Tyr Asn Phe Ala Lys Gln Arg Leu Glu Gln 
305                 310                 315                 320 
Phe Lys Arg Ile Gln Ser Leu Asn Asn Leu Leu Val Val Lys Lys Leu 
                325                 330                 335     
Asn Asp Phe Phe Asp Ser Glu Phe Phe Ser Gly Glu Glu Thr Tyr Thr 
            340                 345                 350         
Ile Cys Val His His Leu Gly Gly Lys Arg Leu Ser Lys Leu Tyr Lys 
        355                 360                 365             
Ala Trp Glu Asp Asp Pro Ala Asp Pro Glu Asn Ala Ile Val Val Leu 
    370                 375                 380                 
Cys Asp Asp Leu Lys Asn Asn Phe Lys Lys Glu Pro Ile Arg Asn Ile 
385                 390                 395                 400 
Leu Arg Tyr Ile Phe Thr Ile Arg Gln Glu Cys Ser Ala Gln Asp Ile 
                405                 410                 415     
Leu Ala Ala Ala Lys Tyr Asn Gln Gln Leu Asp Arg Tyr Lys Ser Gln 
            420                 425                 430         
Lys Ala Asn Pro Ser Val Leu Gly Asn Gln Gly Phe Thr Trp Arg Asn 
        435                 440                 445             
Ala Val Ile Leu Pro Glu Lys Ala Gln Arg Asn Asp Arg Pro Asn Ser 
    450                 455                 460                 
Leu Asp Leu Arg Ile Trp Leu Tyr Leu Lys Leu Arg His Pro Asp Gly 
465                 470                 475                 480 
Arg Trp Lys Lys His His Ile Pro Phe Tyr Asp Thr Arg Phe Phe Gln 
                485                 490                 495     
Glu Ile Tyr Ala Ala Gly Asn Ser Pro Val Asp Thr Cys Gln Phe Arg 
            500                 505                 510         
Thr Pro Arg Phe Gly Tyr His Leu Pro Lys Leu Thr Asp Gln Thr Ala 
        515                 520                 525             
Ile Arg Val Asn Lys Lys His Val Lys Ala Ala Lys Thr Glu Ala Arg 
    530                 535                 540                 
Ile Arg Leu Ala Ile Gln Gln Gly Thr Leu Pro Val Ser Asn Leu Lys 
545                 550                 555                 560 
Ile Thr Arg Ile Ser Ala Thr Ile Asn Ser Lys Gly Gln Val Arg Ile 
                565                 570                 575     
Pro Val Lys Phe Asp Val Gly Arg Gln Lys Gly Thr Leu Gln Ile Gly 
            580                 585                 590         
Asp Arg Phe Cys Gly Tyr Asp Gln Asn Gln Thr Ala Ser His Ala Tyr 
        595                 600                 605             
Ser Leu Trp Glu Val Val Lys Glu Gly Gln Tyr His Lys Glu Leu Gly 
    610                 615                 620                 
Cys Phe Val Arg Phe Ile Ser Ser Gly Asp Ile Val Ser Ile Thr Glu 
625                 630                 635                 640 
Asn Arg Gly Asn Gln Phe Asp Gln Leu Ser Tyr Glu Gly Leu Ala Tyr 
                645                 650                 655     
Pro Gln Tyr Ala Asp Trp Arg Lys Lys Ala Ser Lys Phe Val Ser Leu 
            660                 665                 670         
Trp Gln Ile Thr Lys Lys Asn Lys Lys Lys Glu Ile Val Thr Val Glu 
        675                 680                 685             
Ala Lys Glu Lys Phe Asp Ala Ile Cys Lys Tyr Gln Pro Arg Leu Tyr 
    690                 695                 700                 
Lys Phe Asn Lys Glu Tyr Ala Tyr Leu Leu Arg Asp Ile Val Arg Gly 
705                 710                 715                 720 
Lys Ser Leu Val Glu Leu Gln Gln Ile Arg Gln Glu Ile Phe Arg Phe 
                725                 730                 735     
Ile Glu Gln Asp Cys Gly Val Thr Arg Leu Gly Ser Leu Ser Leu Ser 
            740                 745                 750         
Thr Leu Glu Thr Val Lys Ala Val Lys Gly Ile Ile Tyr Ser Tyr Phe 
        755                 760                 765             
Ser Thr Ala Leu Asn Ala Ser Lys Asn Asn Pro Ile Ser Asp Glu Gln 
    770                 775                 780                 
Arg Lys Glu Phe Asp Pro Glu Leu Phe Ala Leu Leu Glu Lys Leu Glu 
785                 790                 795                 800 
Leu Ile Arg Thr Arg Lys Lys Lys Gln Lys Val Glu Arg Ile Ala Asn 
                805                 810                 815     
Ser Leu Ile Gln Thr Cys Leu Glu Asn Asn Ile Lys Phe Ile Arg Gly 
            820                 825                 830         
Glu Gly Asp Leu Ser Thr Thr Asn Asn Ala Thr Ala Lys Lys Ala Asn 
        835                 840                 845             
Ser Arg Ser Met Asp Trp Leu Ala Ala Gly Val Phe Asn Lys Ile Arg 
    850                 855                 860                 
Gln Leu Ala Pro Met His Asn Ile Thr Leu Phe Gly Cys Gly Ser Leu 
865                 870                 875                 880 
Tyr Thr Ser His Gln Asp Pro Leu Val His Arg Asn Pro Asp Lys Ala 
                885                 890                 895     
Met Lys Cys Arg Trp Ala Ala Ile Pro Val Lys Asp Ile Gly Asp Trp 
            900                 905                 910         
Val Leu Arg Lys Leu Ser Gln Asn Leu Arg Ala Lys Asn Ile Gly Thr 
        915                 920                 925             
Gly Glu Tyr Tyr His Gln Gly Val Lys Glu Phe Leu Ser His Tyr Glu 
    930                 935                 940                 
Leu Gln Asp Leu Glu Glu Glu Leu Leu Lys Trp Arg Ser Asp Arg Lys 
945                 950                 955                 960 
Ser Asn Ile Pro Cys Trp Val Leu Gln Asn Arg Leu Ala Glu Lys Leu 
                965                 970                 975     
Gly Asn Lys Glu Ala Val Val Tyr Ile Pro Val Arg Gly Gly Arg Ile 
            980                 985                 990         
Tyr Phe Ala Thr His Lys Val Ala  Thr Gly Ala Val Ser  Ile Val Phe 
        995                 1000                 1005             
Asp Gln  Lys Gln Val Trp Val  Cys Asn Ala Asp His  Val Ala Ala Ala 
    1010                 1015                 1020                 
Asn  Ile Ala Leu Thr Val  Lys Gly Ile Gly Glu  Gln Ser Ser Asp Glu  
1025                 1030                 1035                 1040 
Glu Asn Pro Asp Gly  Ser Arg Ile Lys Leu  Gln Leu Thr Ser 
                1045                 1050                 

<210>  25
<211>  34
<212>  DNA/RNA
<213>  Artificial Sequence

<400>  25
gtttaattga gttgtcatat gttaataacg gtat                                    34

<210>  26
<211>  34
<212>  DNA/RNA
<213>  Artificial Sequence

<400>  26
ataccgttat taacatatga caactcaatt aaac                                    34

<210>  27
<211>  20
<212>  DNA/RNA
<213>  Artificial Sequence

<400>  27
tggttgccca ccctagtcat                                                    20

<210>  28
<211>  20
<212>  DNA/RNA
<213>  Artificial Sequence

<400>  28
tggttgccca ccctagtcat                                                    20

<210>  29
<211>  20
<212>  DNA/RNA
<213>  Artificial Sequence

<400>  29
tgtttgccca ccctagtcct                                                    20

<210>  30
<211>  20
<212>  DNA/RNA
<213>  Artificial Sequence

<400>  30
tgattgccca ccctactcct                                                    20

<210>  31
<211>  20
<212>  DNA/RNA
<213>  Artificial Sequence

<400>  31
tggtcaccca ccctagtctg                                                    20

<210>  32
<211>  20
<212>  DNA/RNA
<213>  Artificial Sequence

<400>  32
tacaggaggc aataacagat                                                    20

<210>  33
<211>  20
<212>  DNA/RNA
<213>  Artificial Sequence

<400>  33
gccaggaggc aataacagat                                                    20

<210>  34
<211>  20
<212>  DNA/RNA
<213>  Artificial Sequence

<400>  34
tacattaggc aataacagat                                                    20

<210>  35
<211>  20
<212>  DNA/RNA
<213>  Artificial Sequence

<400>  35
tacaggaggc aataacctat                                                    20

<210>  36
<211>  20
<212>  DNA/RNA
<213>  Artificial Sequence

<400>  36
tacaggaggc aataacagcg                                                    20

<210>  37
<211>  20
<212>  DNA/RNA
<213>  Artificial Sequence

<400>  37
accttgtaga tgaactcgcc                                                    20

<210>  38
<211>  20
<212>  DNA/RNA
<213>  Artificial Sequence

<400>  38
cacttgtaga tgaactcgcc                                                    20

<210>  39
<211>  20
<212>  DNA/RNA
<213>  Artificial Sequence

<400>  39
acctgttaga tgaactcgcc                                                    20

<210>  40
<211>  20
<212>  DNA/RNA
<213>  Artificial Sequence

<400>  40
accttgtaga tgaactcgaa                                                    20

<210>  41
<211>  19
<212>  DNA/RNA
<213>  Artificial Sequence

<400>  41
taatacgact cactatagg                                                     19

<210>  42
<211>  67
<212>  DNA/RNA
<213>  Artificial Sequence

<400>  42
aaaaatttgt ttggatatgt tgaaccgtca atgaaagacg gatttctccc tatagtgagt        60
cgtatta                                                                  67

<210>  43
<211>  24
<212>  DNA/RNA
<213>  Artificial Sequence

<400>  43
cttcttcaac atatccaaac aaat                                               24

<210>  44
<211>  24
<212>  DNA/RNA
<213>  Artificial Sequence

<400>  44
ctacttcaac atatccaaac aaat                                               24

<210>  45
<211>  24
<212>  DNA/RNA
<213>  Artificial Sequence

<400>  45
ctccttcaac atatccaaac aaat                                               24

<210>  46
<211>  24
<212>  DNA/RNA
<213>  Artificial Sequence

<400>  46
ctgcttcaac atatccaaac aaat                                               24

<210>  47
<211>  24
<212>  DNA/RNA
<213>  Artificial Sequence

<400>  47
catcttcaac atatccaaac aaat                                               24

<210>  48
<211>  24
<212>  DNA/RNA
<213>  Artificial Sequence

<400>  48
caacttcaac atatccaaac aaat                                               24

<210>  49
<211>  24
<212>  DNA/RNA
<213>  Artificial Sequence

<400>  49
caccttcaac atatccaaac aaat                                               24

<210>  50
<211>  24
<212>  DNA/RNA
<213>  Artificial Sequence

<400>  50
cagcttcaac atatccaaac aaat                                               24

<210>  51
<211>  24
<212>  DNA/RNA
<213>  Artificial Sequence

<400>  51
cctcttcaac atatccaaac aaat                                               24

<210>  52
<211>  24
<212>  DNA/RNA
<213>  Artificial Sequence

<400>  52
ccacttcaac atatccaaac aaat                                               24

<210>  53
<211>  24
<212>  DNA/RNA
<213>  Artificial Sequence

<400>  53
ccccttcaac atatccaaac aaat                                               24

<210>  54
<211>  24
<212>  DNA/RNA
<213>  Artificial Sequence

<400>  54
ccgcttcaac atatccaaac aaat                                               24

<210>  55
<211>  24
<212>  DNA/RNA
<213>  Artificial Sequence

<400>  55
cgtcttcaac atatccaaac aaat                                               24

<210>  56
<211>  24
<212>  DNA/RNA
<213>  Artificial Sequence

<400>  56
cgacttcaac atatccaaac aaat                                               24

<210>  57
<211>  24
<212>  DNA/RNA
<213>  Artificial Sequence

<400>  57
cgccttcaac atatccaaac aaat                                               24

<210>  58
<211>  24
<212>  DNA/RNA
<213>  Artificial Sequence

<400>  58
cggcttcaac atatccaaac aaat                                               24

<210>  59
<211>  23
<212>  DNA/RNA
<213>  Artificial Sequence

<400>  59
agaaatccgt ctttcattga cgg                                                23

<210>  60
<211>  20
<212>  DNA/RNA
<213>  Artificial Sequence

<400>  60
aggccaaaga attcctggaa                                                    20

<210>  61
<211>  20
<212>  DNA/RNA
<213>  Artificial Sequence

<400>  61
ttcaacatat ccaaacaaat                                                    20

<210>  62
<211>  20
<212>  DNA/RNA
<213>  Artificial Sequence

<400>  62
tcctgaacac cttccaggaa                                                    20

<210>  63
<211>  20
<212>  DNA/RNA
<213>  Artificial Sequence

<400>  63
gtgggagatg ttgcaaggct                                                    20

<210>  64
<211>  20
<212>  DNA/RNA
<213>  Artificial Sequence

<400>  64
atgtcactta ggataggaga                                                    20

<210>  65
<211>  20
<212>  DNA/RNA
<213>  Artificial Sequence

<400>  65
ttgcctcctg taaaagagtc                                                    20

<210>  66
<211>  9
<212>  PRT
<213>  Artificial Sequence

<400>  66
Pro Lys Lys Lys Arg Lys Val Pro Gly 
1               5                   

<210>  67
<211>  9
<212>  PRT
<213>  Artificial Sequence

<400>  67
Ala Ser Pro Lys Lys Lys Arg Lys Val 
1               5                   

<210>  68
<211>  17
<212>  DNA/RNA
<213>  Artificial Sequence

<220>
<221>  misc_feature
<222>  (6)..(11)
<223>  任意碱基


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  n is a, c, g, t or u


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n is a, c, g, t or u


<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  n is a, c, g, t or u


<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  n is a, c, g, t or u


<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  n is a, c, g, t or u


<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  n is a, c, g, t or u


<400>  68
ccgucnnnnn nugacgg                                                       17

<210>  69
<211>  17
<212>  DNA/RNA
<213>  Artificial Sequence

<220>
<221>  misc_feature
<222>  (6)..(11)
<223>  任意碱基


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  n is a, c, g, t or u


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n is a, c, g, t or u


<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  n is a, c, g, t or u


<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  n is a, c, g, t or u


<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  n is a, c, g, t or u


<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  n is a, c, g, t or u


<400>  69
gugccnnnnn nuggcac                                                       17

<210>  70
<211>  16
<212>  DNA/RNA
<213>  Artificial Sequence

<220>
<221>  misc_feature
<222>  (6)..(10)
<223>  任意碱基


<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  c,t,u


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  n is a, c, g, t or u


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n is a, c, g, t or u


<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  n is a, c, g, t or u


<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  n is a, c, g, t or u


<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  n is a, c, g, t or u


<400>  70
gugucnnnnn ugacan                                                        16

<210>  71
<211>  17
<212>  DNA/RNA
<213>  Artificial Sequence

<220>
<221>  misc_feature
<222>  (6)..(11)
<223>  任意碱基


<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  c,t,u


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  n is a, c, g, t or u


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n is a, c, g, t or u


<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  n is a, c, g, t or u


<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  n is a, c, g, t or u


<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  n is a, c, g, t or u


<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  n is a, c, g, t or u


<400>  71
gugucnnnnn nugacan                                                       17

<210>  72
<211>  14
<212>  DNA/RNA
<213>  Artificial Sequence

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  c,t,u


<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  a,t,u


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  a,c,g


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  a,g


<400>  72
ucnunnnuug acgg                                                          14

<210>  73
<211>  14
<212>  DNA/RNA
<213>  Artificial Sequence

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  c,t,u


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  a,t,u


<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  c,t,u


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  a,g


<400>  73
ccnnncnuug gcac                                                          14

<210>  74
<211>  2
<212>  PRT
<213>  Artificial Sequence

<400>  74
Gly Ser 
1       

<210>  75
<211>  4
<212>  PRT
<213>  Artificial Sequence

<400>  75
Gly Gly Gly Ser 
1               

<210>  76
<211>  5
<212>  PRT
<213>  Artificial Sequence

<400>  76
Gly Gly Gly Gly Ser 
1               5   

<210>  77
<211>  23
<212>  DNA/RNA
<213>  Artificial Sequence

<400>  77
ttntggttgc ccaccctagt cat                                                23

<210>  78
<211>  23
<212>  DNA/RNA
<213>  Artificial Sequence

<400>  78
ttnaaccact agcactagcc ttg                                                23

<210>  79
<211>  36
<212>  DNA/RNA
<213>  Artificial Sequence

<400>  79
gttgcaaaac ccaagaaatc cgtctttcat tgacgg                                  36

