                         SEQUENCE LISTING

<110>  SANGAMO THERAPEUTICS, INC. 
       ZHANG, LEI
       REIK, ANDREAS
 
<120>  CIITA ZINC FINGER NUCLEASES

<130>  4341.023PC01

<150>  US 63/202,029
<151>  2021-05-24

<160>  57    

<170>  PatentIn version 3.5

<210>  1
<211>  1130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CIITA Isoform 1 (UniProt identifier: P33076-1)

<400>  1

Met Arg Cys Leu Ala Pro Arg Pro Ala Gly Ser Tyr Leu Ser Glu Pro 
1               5                   10                  15      


Gln Gly Ser Ser Gln Cys Ala Thr Met Glu Leu Gly Pro Leu Glu Gly 
            20                  25                  30          


Gly Tyr Leu Glu Leu Leu Asn Ser Asp Ala Asp Pro Leu Cys Leu Tyr 
        35                  40                  45              


His Phe Tyr Asp Gln Met Asp Leu Ala Gly Glu Glu Glu Ile Glu Leu 
    50                  55                  60                  


Tyr Ser Glu Pro Asp Thr Asp Thr Ile Asn Cys Asp Gln Phe Ser Arg 
65                  70                  75                  80  


Leu Leu Cys Asp Met Glu Gly Asp Glu Glu Thr Arg Glu Ala Tyr Ala 
                85                  90                  95      


Asn Ile Ala Glu Leu Asp Gln Tyr Val Phe Gln Asp Ser Gln Leu Glu 
            100                 105                 110         


Gly Leu Ser Lys Asp Ile Phe Lys His Ile Gly Pro Asp Glu Val Ile 
        115                 120                 125             


Gly Glu Ser Met Glu Met Pro Ala Glu Val Gly Gln Lys Ser Gln Lys 
    130                 135                 140                 


Arg Pro Phe Pro Glu Glu Leu Pro Ala Asp Leu Lys His Trp Lys Pro 
145                 150                 155                 160 


Ala Glu Pro Pro Thr Val Val Thr Gly Ser Leu Leu Val Arg Pro Val 
                165                 170                 175     


Ser Asp Cys Ser Thr Leu Pro Cys Leu Pro Leu Pro Ala Leu Phe Asn 
            180                 185                 190         


Gln Glu Pro Ala Ser Gly Gln Met Arg Leu Glu Lys Thr Asp Gln Ile 
        195                 200                 205             


Pro Met Pro Phe Ser Ser Ser Ser Leu Ser Cys Leu Asn Leu Pro Glu 
    210                 215                 220                 


Gly Pro Ile Gln Phe Val Pro Thr Ile Ser Thr Leu Pro His Gly Leu 
225                 230                 235                 240 


Trp Gln Ile Ser Glu Ala Gly Thr Gly Val Ser Ser Ile Phe Ile Tyr 
                245                 250                 255     


His Gly Glu Val Pro Gln Ala Ser Gln Val Pro Pro Pro Ser Gly Phe 
            260                 265                 270         


Thr Val His Gly Leu Pro Thr Ser Pro Asp Arg Pro Gly Ser Thr Ser 
        275                 280                 285             


Pro Phe Ala Pro Ser Ala Thr Asp Leu Pro Ser Met Pro Glu Pro Ala 
    290                 295                 300                 


Leu Thr Ser Arg Ala Asn Met Thr Glu His Lys Thr Ser Pro Thr Gln 
305                 310                 315                 320 


Cys Pro Ala Ala Gly Glu Val Ser Asn Lys Leu Pro Lys Trp Pro Glu 
                325                 330                 335     


Pro Val Glu Gln Phe Tyr Arg Ser Leu Gln Asp Thr Tyr Gly Ala Glu 
            340                 345                 350         


Pro Ala Gly Pro Asp Gly Ile Leu Val Glu Val Asp Leu Val Gln Ala 
        355                 360                 365             


Arg Leu Glu Arg Ser Ser Ser Lys Ser Leu Glu Arg Glu Leu Ala Thr 
    370                 375                 380                 


Pro Asp Trp Ala Glu Arg Gln Leu Ala Gln Gly Gly Leu Ala Glu Val 
385                 390                 395                 400 


Leu Leu Ala Ala Lys Glu His Arg Arg Pro Arg Glu Thr Arg Val Ile 
                405                 410                 415     


Ala Val Leu Gly Lys Ala Gly Gln Gly Lys Ser Tyr Trp Ala Gly Ala 
            420                 425                 430         


Val Ser Arg Ala Trp Ala Cys Gly Arg Leu Pro Gln Tyr Asp Phe Val 
        435                 440                 445             


Phe Ser Val Pro Cys His Cys Leu Asn Arg Pro Gly Asp Ala Tyr Gly 
    450                 455                 460                 


Leu Gln Asp Leu Leu Phe Ser Leu Gly Pro Gln Pro Leu Val Ala Ala 
465                 470                 475                 480 


Asp Glu Val Phe Ser His Ile Leu Lys Arg Pro Asp Arg Val Leu Leu 
                485                 490                 495     


Ile Leu Asp Gly Phe Glu Glu Leu Glu Ala Gln Asp Gly Phe Leu His 
            500                 505                 510         


Ser Thr Cys Gly Pro Ala Pro Ala Glu Pro Cys Ser Leu Arg Gly Leu 
        515                 520                 525             


Leu Ala Gly Leu Phe Gln Lys Lys Leu Leu Arg Gly Cys Thr Leu Leu 
    530                 535                 540                 


Leu Thr Ala Arg Pro Arg Gly Arg Leu Val Gln Ser Leu Ser Lys Ala 
545                 550                 555                 560 


Asp Ala Leu Phe Glu Leu Ser Gly Phe Ser Met Glu Gln Ala Gln Ala 
                565                 570                 575     


Tyr Val Met Arg Tyr Phe Glu Ser Ser Gly Met Thr Glu His Gln Asp 
            580                 585                 590         


Arg Ala Leu Thr Leu Leu Arg Asp Arg Pro Leu Leu Leu Ser His Ser 
        595                 600                 605             


His Ser Pro Thr Leu Cys Arg Ala Val Cys Gln Leu Ser Glu Ala Leu 
    610                 615                 620                 


Leu Glu Leu Gly Glu Asp Ala Lys Leu Pro Ser Thr Leu Thr Gly Leu 
625                 630                 635                 640 


Tyr Val Gly Leu Leu Gly Arg Ala Ala Leu Asp Ser Pro Pro Gly Ala 
                645                 650                 655     


Leu Ala Glu Leu Ala Lys Leu Ala Trp Glu Leu Gly Arg Arg His Gln 
            660                 665                 670         


Ser Thr Leu Gln Glu Asp Gln Phe Pro Ser Ala Asp Val Arg Thr Trp 
        675                 680                 685             


Ala Met Ala Lys Gly Leu Val Gln His Pro Pro Arg Ala Ala Glu Ser 
    690                 695                 700                 


Glu Leu Ala Phe Pro Ser Phe Leu Leu Gln Cys Phe Leu Gly Ala Leu 
705                 710                 715                 720 


Trp Leu Ala Leu Ser Gly Glu Ile Lys Asp Lys Glu Leu Pro Gln Tyr 
                725                 730                 735     


Leu Ala Leu Thr Pro Arg Lys Lys Arg Pro Tyr Asp Asn Trp Leu Glu 
            740                 745                 750         


Gly Val Pro Arg Phe Leu Ala Gly Leu Ile Phe Gln Pro Pro Ala Arg 
        755                 760                 765             


Cys Leu Gly Ala Leu Leu Gly Pro Ser Ala Ala Ala Ser Val Asp Arg 
    770                 775                 780                 


Lys Gln Lys Val Leu Ala Arg Tyr Leu Lys Arg Leu Gln Pro Gly Thr 
785                 790                 795                 800 


Leu Arg Ala Arg Gln Leu Leu Glu Leu Leu His Cys Ala His Glu Ala 
                805                 810                 815     


Glu Glu Ala Gly Ile Trp Gln His Val Val Gln Glu Leu Pro Gly Arg 
            820                 825                 830         


Leu Ser Phe Leu Gly Thr Arg Leu Thr Pro Pro Asp Ala His Val Leu 
        835                 840                 845             


Gly Lys Ala Leu Glu Ala Ala Gly Gln Asp Phe Ser Leu Asp Leu Arg 
    850                 855                 860                 


Ser Thr Gly Ile Cys Pro Ser Gly Leu Gly Ser Leu Val Gly Leu Ser 
865                 870                 875                 880 


Cys Val Thr Arg Phe Arg Ala Ala Leu Ser Asp Thr Val Ala Leu Trp 
                885                 890                 895     


Glu Ser Leu Gln Gln His Gly Glu Thr Lys Leu Leu Gln Ala Ala Glu 
            900                 905                 910         


Glu Lys Phe Thr Ile Glu Pro Phe Lys Ala Lys Ser Leu Lys Asp Val 
        915                 920                 925             


Glu Asp Leu Gly Lys Leu Val Gln Thr Gln Arg Thr Arg Ser Ser Ser 
    930                 935                 940                 


Glu Asp Thr Ala Gly Glu Leu Pro Ala Val Arg Asp Leu Lys Lys Leu 
945                 950                 955                 960 


Glu Phe Ala Leu Gly Pro Val Ser Gly Pro Gln Ala Phe Pro Lys Leu 
                965                 970                 975     


Val Arg Ile Leu Thr Ala Phe Ser Ser Leu Gln His Leu Asp Leu Asp 
            980                 985                 990         


Ala Leu Ser Glu Asn Lys Ile Gly  Asp Glu Gly Val Ser  Gln Leu Ser 
        995                 1000                 1005             


Ala Thr  Phe Pro Gln Leu Lys  Ser Leu Glu Thr Leu  Asn Leu Ser 
    1010                 1015                 1020             


Gln Asn  Asn Ile Thr Asp Leu  Gly Ala Tyr Lys Leu  Ala Glu Ala 
    1025                 1030                 1035             


Leu Pro  Ser Leu Ala Ala Ser  Leu Leu Arg Leu Ser  Leu Tyr Asn 
    1040                 1045                 1050             


Asn Cys  Ile Cys Asp Val Gly  Ala Glu Ser Leu Ala  Arg Val Leu 
    1055                 1060                 1065             


Pro Asp  Met Val Ser Leu Arg  Val Met Asp Val Gln  Tyr Asn Lys 
    1070                 1075                 1080             


Phe Thr  Ala Ala Gly Ala Gln  Gln Leu Ala Ala Ser  Leu Arg Arg 
    1085                 1090                 1095             


Cys Pro  His Val Glu Thr Leu  Ala Met Trp Thr Pro  Thr Ile Pro 
    1100                 1105                 1110             


Phe Ser  Val Gln Glu His Leu  Gln Gln Gln Asp Ser  Arg Ile Ser 
    1115                 1120                 1125             


Leu Arg  
    1130 


<210>  2
<211>  883
<212>  PRT
<213>  artificial sequence

<220>
<223>  CIITA Isoform 2 (identifier: P33076-2)

<400>  2

Met Arg Cys Leu Ala Pro Arg Pro Ala Gly Ser Tyr Leu Ser Glu Pro 
1               5                   10                  15      


Gln Gly Ser Ser Gln Cys Ala Thr Met Glu Leu Gly Pro Leu Glu Gly 
            20                  25                  30          


Gly Tyr Leu Glu Leu Leu Asn Ser Asp Ala Asp Pro Leu Cys Leu Tyr 
        35                  40                  45              


His Phe Tyr Asp Gln Met Asp Leu Ala Gly Glu Glu Glu Ile Glu Leu 
    50                  55                  60                  


Tyr Ser Glu Pro Asp Thr Asp Thr Ile Asn Cys Asp Gln Phe Ser Arg 
65                  70                  75                  80  


Leu Leu Cys Asp Met Glu Gly Asp Glu Glu Thr Arg Glu Ala Tyr Ala 
                85                  90                  95      


Asn Ile Ala Glu Leu Asp Gln Tyr Val Phe Gln Asp Ser Gln Leu Glu 
            100                 105                 110         


Gly Leu Ser Lys Asp Ile Phe Lys His Ile Gly Pro Asp Glu Val Ile 
        115                 120                 125             


Gly Glu Ser Met Glu Met Pro Ala Glu Val Gly Gln Lys Ser Gln Lys 
    130                 135                 140                 


Arg Pro Phe Pro Glu Glu Leu Pro Ala Asp Leu Lys His Trp Lys Pro 
145                 150                 155                 160 


Val Pro Phe Ser Ser Ser Ser Leu Ser Cys Leu Asn Leu Pro Glu Gly 
                165                 170                 175     


Pro Ile Gln Phe Val Pro Thr Ile Ser Thr Leu Pro His Gly Leu Trp 
            180                 185                 190         


Gln Ile Ser Glu Ala Gly Thr Gly Val Ser Ser Ile Phe Ile Tyr His 
        195                 200                 205             


Gly Glu Val Pro Gln Ala Ser Gln Val Pro Pro Pro Ser Gly Phe Thr 
    210                 215                 220                 


Val His Gly Leu Pro Thr Ser Pro Asp Arg Pro Gly Ser Thr Ser Pro 
225                 230                 235                 240 


Phe Ala Pro Ser Ala Thr Asp Leu Pro Ser Met Pro Glu Pro Ala Leu 
                245                 250                 255     


Thr Ser Arg Ala Asn Met Thr Glu His Lys Thr Ser Pro Thr Gln Cys 
            260                 265                 270         


Pro Ala Ala Gly Glu Val Ser Asn Lys Leu Pro Lys Trp Pro Glu Pro 
        275                 280                 285             


Val Glu Gln Phe Tyr Arg Ser Leu Gln Asp Thr Tyr Gly Ala Glu Pro 
    290                 295                 300                 


Ala Gly Pro Asp Gly Ile Leu Val Glu Val Asp Leu Val Gln Ala Arg 
305                 310                 315                 320 


Leu Glu Arg Ser Ser Ser Lys Ser Leu Glu Arg Glu Leu Ala Thr Pro 
                325                 330                 335     


Asp Trp Ala Glu Arg Gln Leu Ala Gln Gly Gly Leu Ala Glu Val Leu 
            340                 345                 350         


Leu Ala Ala Lys Glu His Arg Arg Pro Arg Glu Thr Arg Val Ile Ala 
        355                 360                 365             


Val Leu Gly Lys Ala Gly Gln Gly Lys Ser Tyr Trp Ala Gly Ala Val 
    370                 375                 380                 


Ser Arg Ala Trp Ala Cys Gly Arg Leu Pro Gln Tyr Asp Phe Val Phe 
385                 390                 395                 400 


Ser Val Pro Cys His Cys Leu Asn Arg Pro Gly Asp Ala Tyr Gly Leu 
                405                 410                 415     


Gln Asp Leu Leu Phe Ser Leu Gly Pro Gln Pro Leu Val Ala Ala Asp 
            420                 425                 430         


Glu Val Phe Ser His Ile Leu Lys Arg Pro Asp Arg Val Leu Leu Ile 
        435                 440                 445             


Leu Asp Gly Phe Glu Glu Leu Glu Ala Gln Asp Gly Phe Leu His Ser 
    450                 455                 460                 


Thr Cys Gly Pro Ala Pro Ala Glu Pro Cys Ser Leu Arg Gly Leu Leu 
465                 470                 475                 480 


Ala Gly Leu Phe Gln Lys Lys Leu Leu Arg Gly Cys Thr Leu Leu Leu 
                485                 490                 495     


Thr Ala Arg Pro Arg Gly Arg Leu Val Gln Ser Leu Ser Lys Ala Asp 
            500                 505                 510         


Ala Leu Phe Glu Leu Ser Gly Phe Ser Met Glu Gln Ala Gln Ala Tyr 
        515                 520                 525             


Val Met Arg Tyr Phe Glu Ser Ser Gly Met Thr Glu His Gln Asp Arg 
    530                 535                 540                 


Ala Leu Thr Leu Leu Arg Asp Arg Pro Leu Leu Leu Ser His Ser His 
545                 550                 555                 560 


Ser Pro Thr Leu Cys Arg Ala Val Cys Gln Leu Ser Glu Ala Leu Leu 
                565                 570                 575     


Glu Leu Gly Glu Asp Ala Lys Leu Pro Ser Thr Leu Thr Gly Leu Tyr 
            580                 585                 590         


Val Gly Leu Leu Gly Arg Ala Ala Leu Asp Ser Pro Pro Gly Ala Leu 
        595                 600                 605             


Ala Glu Leu Ala Lys Leu Ala Trp Glu Leu Gly Arg Arg His Gln Ser 
    610                 615                 620                 


Thr Leu Gln Glu Asp Gln Phe Pro Ser Ala Asp Val Arg Thr Trp Ala 
625                 630                 635                 640 


Met Ala Lys Gly Leu Val Gln His Pro Pro Arg Ala Ala Glu Ser Glu 
                645                 650                 655     


Leu Ala Phe Pro Ser Phe Leu Leu Gln Cys Phe Leu Gly Ala Leu Trp 
            660                 665                 670         


Leu Ala Leu Ser Gly Glu Ile Lys Asp Lys Glu Leu Pro Gln Tyr Leu 
        675                 680                 685             


Ala Leu Thr Pro Arg Lys Lys Arg Pro Tyr Asp Asn Trp Leu Glu Gly 
    690                 695                 700                 


Val Pro Arg Phe Leu Ala Gly Leu Ile Phe Gln Pro Pro Ala Arg Cys 
705                 710                 715                 720 


Leu Gly Ala Leu Leu Gly Pro Ser Ala Ala Ala Ser Val Asp Arg Lys 
                725                 730                 735     


Gln Lys Val Leu Ala Arg Tyr Leu Lys Arg Leu Gln Pro Gly Thr Leu 
            740                 745                 750         


Arg Ala Arg Gln Leu Leu Glu Leu Leu His Cys Ala His Glu Ala Glu 
        755                 760                 765             


Glu Ala Gly Ile Trp Gln His Val Val Gln Glu Leu Pro Gly Arg Leu 
    770                 775                 780                 


Ser Phe Leu Gly Thr Arg Leu Thr Pro Pro Asp Ala His Val Leu Gly 
785                 790                 795                 800 


Lys Ala Leu Glu Ala Ala Gly Gln Asp Phe Ser Leu Asp Leu Arg Ser 
                805                 810                 815     


Thr Gly Ile Cys Pro Ser Gly Leu Gly Ser Leu Val Gly Leu Ser Cys 
            820                 825                 830         


Val Thr Arg Phe Arg Trp Gly Glu Gly Leu Gly Arg Asp Ile Leu Val 
        835                 840                 845             


Leu Gly Ile Asn Cys Gly Leu Gly Ala Lys Pro Ser Ala Leu Trp Gly 
    850                 855                 860                 


Pro Phe Ser Met Gln Ser Ser Arg Val Gly Gln Asn Gly Phe Ser Pro 
865                 870                 875                 880 


Phe Leu Arg 
            


<210>  3
<211>  545
<212>  PRT
<213>  artificial sequence

<220>
<223>  "CIITA Isoform 3 (identifier: P33076-3) "

<400>  3

Met Arg Cys Leu Ala Pro Arg Pro Ala Gly Ser Tyr Leu Ser Glu Pro 
1               5                   10                  15      


Gln Gly Ser Ser Gln Cys Ala Thr Met Glu Leu Gly Pro Leu Glu Gly 
            20                  25                  30          


Gly Tyr Leu Glu Leu Leu Asn Ser Asp Ala Asp Pro Leu Cys Leu Tyr 
        35                  40                  45              


His Phe Tyr Asp Gln Met Asp Leu Ala Gly Glu Glu Glu Ile Glu Leu 
    50                  55                  60                  


Tyr Ser Glu Pro Asp Thr Asp Thr Ile Asn Cys Asp Gln Phe Ser Arg 
65                  70                  75                  80  


Leu Leu Cys Asp Met Glu Gly Asp Glu Glu Thr Arg Glu Ala Tyr Ala 
                85                  90                  95      


Asn Ile Ala Glu Leu Asp Gln Tyr Val Phe Gln Asp Ser Gln Leu Glu 
            100                 105                 110         


Gly Leu Ser Lys Asp Ile Phe Lys His Ile Gly Pro Asp Glu Val Ile 
        115                 120                 125             


Gly Glu Ser Met Glu Met Pro Ala Glu Val Gly Gln Lys Ser Gln Lys 
    130                 135                 140                 


Arg Pro Phe Pro Glu Glu Leu Pro Ala Asp Leu Lys His Trp Lys Pro 
145                 150                 155                 160 


Val Pro Phe Ser Ser Ser Ser Leu Ser Cys Leu Asn Leu Pro Glu Gly 
                165                 170                 175     


Pro Ile Gln Phe Val Pro Thr Ile Ser Thr Leu Pro His Gly Leu Trp 
            180                 185                 190         


Gln Ile Ser Glu Ala Gly Thr Gly Val Ser Ser Ile Phe Ile Tyr His 
        195                 200                 205             


Gly Glu Val Pro Gln Ala Ser Gln Val Pro Pro Pro Ser Gly Phe Thr 
    210                 215                 220                 


Val His Gly Leu Pro Thr Ser Pro Asp Arg Pro Gly Ser Thr Ser Pro 
225                 230                 235                 240 


Phe Ala Pro Ser Ala Thr Asp Leu Pro Ser Met Pro Glu Pro Ala Leu 
                245                 250                 255     


Thr Ser Arg Ala Asn Met Thr Glu His Lys Thr Ser Pro Thr Gln Cys 
            260                 265                 270         


Pro Ala Ala Gly Glu Val Ser Asn Lys Leu Pro Lys Trp Pro Gly Leu 
        275                 280                 285             


Ala Trp Ser Pro Cys Leu Gly Leu Arg Pro Ser Leu His Arg Ala Ala 
    290                 295                 300                 


Leu Ser Asp Thr Val Ala Leu Trp Glu Ser Leu Gln Gln His Gly Glu 
305                 310                 315                 320 


Thr Lys Leu Leu Gln Ala Ala Glu Glu Lys Phe Thr Ile Glu Pro Phe 
                325                 330                 335     


Lys Ala Lys Ser Leu Lys Asp Val Glu Asp Leu Gly Lys Leu Val Gln 
            340                 345                 350         


Thr Gln Arg Thr Arg Ser Ser Ser Glu Asp Thr Ala Gly Glu Leu Pro 
        355                 360                 365             


Ala Val Arg Asp Leu Lys Lys Leu Glu Phe Ala Gly Pro Val Ser Gly 
    370                 375                 380                 


Pro Gln Ala Phe Pro Lys Leu Val Arg Ile Leu Thr Ala Phe Ser Ser 
385                 390                 395                 400 


Leu Gln His Leu Asp Leu Asp Ala Leu Ser Glu Asn Lys Ile Gly Asp 
                405                 410                 415     


Glu Gly Val Ser Gln Leu Ser Ala Thr Phe Pro Gln Leu Lys Ser Leu 
            420                 425                 430         


Glu Thr Leu Asn Leu Ser Gln Asn Asn Ile Thr Asp Leu Gly Ala Tyr 
        435                 440                 445             


Lys Leu Ala Glu Ala Leu Pro Ser Leu Ala Ala Ser Leu Leu Arg Leu 
    450                 455                 460                 


Ser Leu Tyr Asn Asn Cys Ile Cys Asp Val Gly Ala Glu Ser Leu Ala 
465                 470                 475                 480 


Arg Val Leu Pro Asp Met Val Ser Leu Arg Val Met Asp Val Gln Tyr 
                485                 490                 495     


Asn Lys Phe Thr Ala Ala Gly Ala Gln Gln Leu Ala Ala Ser Leu Arg 
            500                 505                 510         


Arg Cys Pro His Val Glu Thr Leu Ala Met Trp Thr Pro Thr Ile Pro 
        515                 520                 525             


Phe Ser Val Gln Glu His Leu Gln Gln Gln Asp Ser Arg Ile Ser Leu 
    530                 535                 540                 


Arg 
545 


<210>  4
<211>  932
<212>  PRT
<213>  artificial sequence

<220>
<223>  CIITA Isoform 4 (identifier: P33076-4)

<400>  4

Met Arg Cys Leu Ala Pro Arg Pro Ala Gly Ser Tyr Leu Ser Glu Pro 
1               5                   10                  15      


Gln Gly Ser Ser Gln Cys Ala Thr Met Glu Leu Gly Pro Leu Glu Gly 
            20                  25                  30          


Gly Tyr Leu Glu Leu Leu Asn Ser Asp Ala Asp Pro Leu Cys Leu Tyr 
        35                  40                  45              


His Phe Tyr Asp Gln Met Asp Leu Ala Gly Glu Glu Glu Ile Glu Leu 
    50                  55                  60                  


Tyr Ser Glu Pro Asp Thr Asp Thr Ile Asn Cys Asp Gln Phe Ser Arg 
65                  70                  75                  80  


Leu Leu Cys Asp Met Glu Gly Asp Glu Glu Thr Arg Glu Ala Tyr Ala 
                85                  90                  95      


Asn Ile Ala Glu Leu Asp Gln Tyr Val Phe Gln Asp Ser Gln Leu Glu 
            100                 105                 110         


Gly Leu Ser Lys Asp Ile Phe Lys His Ile Gly Pro Asp Glu Val Ile 
        115                 120                 125             


Gly Glu Ser Met Glu Met Pro Ala Glu Val Gly Gln Lys Ser Gln Lys 
    130                 135                 140                 


Arg Pro Phe Pro Glu Glu Leu Pro Ala Asp Leu Lys His Trp Lys Pro 
145                 150                 155                 160 


Ala Glu Pro Pro Thr Val Val Thr Gly Ser Leu Leu Val Arg Pro Val 
                165                 170                 175     


Ser Asp Cys Ser Thr Leu Pro Cys Leu Pro Leu Pro Ala Leu Phe Asn 
            180                 185                 190         


Gln Glu Pro Ala Ser Gly Gln Met Arg Leu Glu Lys Thr Asp Gln Ile 
        195                 200                 205             


Pro Met Pro Phe Ser Ser Ser Ser Leu Ser Cys Leu Asn Leu Pro Glu 
    210                 215                 220                 


Gly Pro Ile Gln Phe Val Pro Thr Ile Ser Thr Leu Pro His Gly Leu 
225                 230                 235                 240 


Trp Gln Ile Ser Glu Ala Gly Thr Gly Val Ser Ser Ile Phe Ile Tyr 
                245                 250                 255     


His Gly Glu Val Pro Gln Ala Ser Gln Val Pro Pro Pro Ser Gly Phe 
            260                 265                 270         


Thr Val His Gly Leu Pro Thr Ser Pro Asp Arg Pro Gly Ser Thr Ser 
        275                 280                 285             


Pro Phe Ala Pro Ser Ala Thr Asp Leu Pro Ser Met Pro Glu Pro Ala 
    290                 295                 300                 


Leu Thr Ser Arg Ala Asn Met Thr Glu His Lys Thr Ser Pro Thr Gln 
305                 310                 315                 320 


Cys Pro Ala Ala Gly Glu Val Ser Asn Lys Leu Pro Lys Trp Pro Glu 
                325                 330                 335     


Pro Val Glu Gln Phe Tyr Arg Ser Leu Gln Asp Thr Tyr Gly Ala Glu 
            340                 345                 350         


Pro Ala Gly Pro Asp Gly Ile Leu Val Glu Val Asp Leu Val Gln Ala 
        355                 360                 365             


Arg Leu Glu Arg Ser Ser Ser Lys Ser Leu Glu Arg Glu Leu Ala Thr 
    370                 375                 380                 


Pro Asp Trp Ala Glu Arg Gln Leu Ala Gln Gly Gly Leu Ala Glu Val 
385                 390                 395                 400 


Leu Leu Ala Ala Lys Glu His Arg Arg Pro Arg Glu Thr Arg Val Ile 
                405                 410                 415     


Ala Val Leu Gly Lys Ala Gly Gln Gly Lys Ser Tyr Trp Ala Gly Ala 
            420                 425                 430         


Val Ser Arg Ala Trp Ala Cys Gly Arg Leu Pro Gln Tyr Asp Phe Val 
        435                 440                 445             


Phe Ser Val Pro Cys His Cys Leu Asn Arg Pro Gly Asp Ala Tyr Gly 
    450                 455                 460                 


Leu Gln Asp Leu Leu Phe Ser Leu Gly Pro Gln Pro Leu Val Ala Ala 
465                 470                 475                 480 


Asp Glu Val Phe Ser His Ile Leu Lys Arg Pro Asp Arg Val Leu Leu 
                485                 490                 495     


Ile Leu Asp Gly Phe Glu Glu Leu Glu Ala Gln Asp Gly Phe Leu His 
            500                 505                 510         


Ser Thr Cys Gly Pro Ala Pro Ala Glu Pro Cys Ser Leu Arg Gly Leu 
        515                 520                 525             


Leu Ala Gly Leu Phe Gln Lys Lys Leu Leu Arg Gly Cys Thr Leu Leu 
    530                 535                 540                 


Leu Thr Ala Arg Pro Arg Gly Arg Leu Val Gln Ser Leu Ser Lys Ala 
545                 550                 555                 560 


Asp Ala Leu Phe Glu Leu Ser Gly Phe Ser Met Glu Gln Ala Gln Ala 
                565                 570                 575     


Tyr Val Met Arg Tyr Phe Glu Ser Ser Gly Met Thr Glu His Gln Asp 
            580                 585                 590         


Arg Ala Leu Thr Leu Leu Arg Asp Arg Pro Leu Leu Leu Ser His Ser 
        595                 600                 605             


His Ser Pro Thr Leu Cys Arg Ala Val Cys Gln Leu Ser Glu Ala Leu 
    610                 615                 620                 


Leu Glu Leu Gly Glu Asp Ala Lys Leu Pro Ser Thr Leu Thr Gly Leu 
625                 630                 635                 640 


Tyr Val Gly Leu Leu Gly Arg Ala Ala Leu Asp Ser Pro Pro Gly Ala 
                645                 650                 655     


Leu Ala Glu Leu Ala Lys Leu Ala Trp Glu Leu Gly Arg Arg His Gln 
            660                 665                 670         


Ser Thr Leu Gln Glu Asp Gln Phe Pro Ser Ala Asp Val Arg Thr Trp 
        675                 680                 685             


Ala Met Ala Lys Gly Leu Val Gln His Pro Pro Arg Ala Ala Glu Ser 
    690                 695                 700                 


Glu Leu Ala Phe Pro Ser Phe Leu Leu Gln Cys Phe Leu Gly Ala Leu 
705                 710                 715                 720 


Trp Leu Ala Leu Ser Gly Glu Ile Lys Asp Lys Glu Leu Pro Gln Tyr 
                725                 730                 735     


Leu Ala Leu Thr Pro Arg Lys Lys Arg Pro Tyr Asp Asn Trp Leu Glu 
            740                 745                 750         


Gly Val Pro Arg Phe Leu Ala Gly Leu Ile Phe Gln Pro Pro Ala Arg 
        755                 760                 765             


Cys Leu Gly Ala Leu Leu Gly Pro Ser Ala Ala Ala Ser Val Asp Arg 
    770                 775                 780                 


Lys Gln Lys Val Leu Ala Arg Tyr Leu Lys Arg Leu Gln Pro Gly Thr 
785                 790                 795                 800 


Leu Arg Ala Arg Gln Leu Leu Glu Leu Leu His Cys Ala His Glu Ala 
                805                 810                 815     


Glu Glu Ala Gly Ile Trp Gln His Val Val Gln Glu Leu Pro Gly Arg 
            820                 825                 830         


Leu Ser Phe Leu Gly Thr Arg Leu Thr Pro Pro Asp Ala His Val Leu 
        835                 840                 845             


Gly Lys Ala Leu Glu Ala Ala Gly Gln Asp Phe Ser Leu Asp Leu Arg 
    850                 855                 860                 


Ser Thr Gly Ile Cys Pro Ser Gly Leu Gly Ser Leu Val Gly Leu Ser 
865                 870                 875                 880 


Cys Val Thr Arg Phe Arg Trp Gly Glu Gly Leu Gly Arg Asp Ile Leu 
                885                 890                 895     


Val Leu Gly Ile Asn Cys Gly Leu Gly Ala Lys Pro Ser Ala Leu Trp 
            900                 905                 910         


Gly Pro Phe Ser Met Gln Ser Ser Arg Val Gly Gln Asn Gly Phe Ser 
        915                 920                 925             


Pro Phe Leu Arg 
    930         


<210>  5
<211>  391
<212>  PRT
<213>  artificial sequence

<220>
<223>  Zinc finger nuclease 76867

<400>  5

Met Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp 
1               5                   10                  15      


Tyr Lys Asp Asp Asp Asp Lys Met Ala Pro Lys Lys Lys Arg Lys Val 
            20                  25                  30          


Gly Ile His Gly Val Pro Ala Ala Met Gly Gln Leu Val Lys Ser Glu 
        35                  40                  45              


Leu Glu Glu Lys Lys Ser Glu Leu Arg His Lys Leu Lys Tyr Val Pro 
    50                  55                  60                  


His Glu Tyr Ile Glu Leu Ile Glu Ile Ala Arg Asn Ser Thr Gln Asp 
65                  70                  75                  80  


Arg Ile Leu Glu Met Lys Val Met Glu Phe Phe Met Lys Val Tyr Gly 
                85                  90                  95      


Tyr Arg Gly Lys His Leu Gly Gly Ser Arg Lys Pro Asp Gly Ala Ile 
            100                 105                 110         


Tyr Thr Val Gly Ser Pro Ile Asp Tyr Gly Val Ile Val Asp Thr Lys 
        115                 120                 125             


Ala Tyr Ser Gly Gly Tyr Asn Leu Pro Ile Gly Gln Ala Asp Glu Met 
    130                 135                 140                 


Glu Arg Tyr Val Glu Glu Asn Gln Thr Arg Asp Lys His Leu Asn Pro 
145                 150                 155                 160 


Asn Glu Trp Trp Lys Val Tyr Pro Ser Ser Val Thr Glu Phe Lys Phe 
                165                 170                 175     


Leu Phe Val Ser Gly His Phe Lys Gly Asn Tyr Lys Ala Gln Leu Thr 
            180                 185                 190         


Arg Leu Asn His Ile Thr Asn Cys Asn Gly Ala Val Leu Ser Val Glu 
        195                 200                 205             


Glu Leu Leu Ile Gly Gly Glu Met Ile Lys Ala Gly Thr Leu Thr Leu 
    210                 215                 220                 


Glu Glu Val Arg Arg Lys Phe Asn Asn Gly Glu Ile Asn Phe Ser Gly 
225                 230                 235                 240 


Ala Gln Gly Ser Thr Leu Asp Phe Arg Pro Phe Gln Cys Arg Ile Cys 
                245                 250                 255     


Met Arg Asn Phe Ser Arg Pro Tyr Thr Leu Arg Leu His Ile Arg Thr 
            260                 265                 270         


His Thr Gly Glu Lys Pro Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe 
        275                 280                 285             


Ala Arg Ser Ala Asn Leu Thr Arg His Thr Lys Ile His Thr Gly Ser 
    290                 295                 300                 


Gln Lys Pro Phe Gln Cys Arg Ile Cys Met Arg Asn Phe Ser Arg Ser 
305                 310                 315                 320 


Asp Ala Leu Ser Thr His Ile Arg Thr His Thr Gly Glu Lys Pro Phe 
                325                 330                 335     


Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Asp Arg Ser Thr Arg Thr 
            340                 345                 350         


Lys His Thr Lys Ile His Thr Gly Glu Lys Pro Phe Gln Cys Arg Ile 
        355                 360                 365             


Cys Met Arg Lys Phe Ala Asp Arg Ser Thr Arg Thr Lys His Thr Lys 
    370                 375                 380                 


Ile His Leu Arg Gln Lys Asp 
385                 390     


<210>  6
<211>  409
<212>  PRT
<213>  artificial sequence

<220>
<223>  zinc finger nuclease 82862

<400>  6

Met Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp 
1               5                   10                  15      


Tyr Lys Asp Asp Asp Asp Lys Met Ala Pro Lys Lys Lys Arg Lys Val 
            20                  25                  30          


Gly Ile His Gly Val Pro Ala Ala Met Ala Glu Arg Pro Phe Gln Cys 
        35                  40                  45              


Arg Ile Cys Met Gln Asn Phe Ser Arg Ser Asp Val Leu Ser Ala His 
    50                  55                  60                  


Ile Arg Thr His Thr Gly Glu Lys Pro Phe Ala Cys Asp Ile Cys Gly 
65                  70                  75                  80  


Lys Lys Phe Ala Asp Arg Ser Asn Arg Ile Lys His Thr Lys Ile His 
                85                  90                  95      


Thr Gly Ser Gln Lys Pro Phe Gln Cys Arg Ile Cys Met Gln Asn Phe 
            100                 105                 110         


Ser Asp Arg Ser His Leu Thr Arg His Ile Arg Thr His Thr Gly Glu 
        115                 120                 125             


Lys Pro Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Leu Lys Gln 
    130                 135                 140                 


His Leu Thr Arg His Thr Lys Ile His Thr Gly Glu Lys Pro Phe Gln 
145                 150                 155                 160 


Cys Arg Ile Cys Met Gln Asn Phe Ser Gln Ser Gly Asn Leu Ala Arg 
                165                 170                 175     


His Ile Arg Thr His Thr Gly Glu Lys Pro Phe Ala Cys Asp Ile Cys 
            180                 185                 190         


Gly Arg Lys Phe Ala Gln Ser Thr Pro Arg Thr Thr His Thr Lys Ile 
        195                 200                 205             


His Leu Arg Gly Ser Gln Leu Val Lys Ser Glu Leu Glu Glu Lys Lys 
    210                 215                 220                 


Ser Glu Leu Arg His Lys Leu Lys Tyr Val Pro His Glu Tyr Ile Glu 
225                 230                 235                 240 


Leu Ile Glu Ile Ala Arg Asn Ser Thr Gln Asp Arg Ile Leu Glu Met 
                245                 250                 255     


Lys Val Met Glu Phe Phe Met Lys Val Tyr Gly Tyr Arg Gly Lys His 
            260                 265                 270         


Leu Gly Gly Ser Arg Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly Ser 
        275                 280                 285             


Pro Ile Asp Tyr Gly Val Ile Val Asp Thr Lys Ala Tyr Ser Gly Gly 
    290                 295                 300                 


Tyr Asn Leu Pro Ile Gly Gln Ala Asp Glu Met Gln Arg Tyr Val Lys 
305                 310                 315                 320 


Glu Asn Gln Thr Arg Asn Lys His Ile Asn Pro Asn Glu Trp Trp Lys 
                325                 330                 335     


Val Tyr Pro Ser Ser Val Thr Glu Phe Lys Phe Leu Phe Val Ser Gly 
            340                 345                 350         


His Phe Lys Gly Asn Tyr Lys Ala Gln Leu Thr Arg Leu Asn Arg Lys 
        355                 360                 365             


Thr Asn Cys Asn Gly Ala Val Leu Ser Val Glu Glu Leu Leu Ile Gly 
    370                 375                 380                 


Gly Glu Met Ile Lys Ala Gly Thr Leu Thr Leu Glu Glu Val Arg Arg 
385                 390                 395                 400 


Lys Phe Asn Asn Gly Glu Ile Asn Phe 
                405                 


<210>  7
<211>  425
<212>  PRT
<213>  artificial sequence

<220>
<223>  zinc finger nuclease 87254

<400>  7

Met Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp 
1               5                   10                  15      


Tyr Lys Asp Asp Asp Asp Lys Met Ala Pro Lys Lys Lys Arg Lys Val 
            20                  25                  30          


Gly Ile His Gly Val Pro Ala Ala Met Gly Gln Leu Val Lys Ser Glu 
        35                  40                  45              


Leu Glu Glu Lys Lys Ser Glu Leu Arg His Lys Leu Lys Tyr Val Pro 
    50                  55                  60                  


His Glu Tyr Ile Glu Leu Ile Glu Ile Ala Arg Asn Ser Thr Gln Asp 
65                  70                  75                  80  


Arg Ile Leu Glu Met Lys Val Met Glu Phe Phe Met Lys Val Tyr Gly 
                85                  90                  95      


Tyr Arg Gly Lys His Leu Gly Gly Ser Arg Lys Pro Asp Gly Ala Ile 
            100                 105                 110         


Tyr Thr Val Gly Ser Pro Ile Asp Tyr Gly Val Ile Val Asp Thr Lys 
        115                 120                 125             


Ala Tyr Ser Gly Gly Tyr Asn Leu Pro Ile Gly Gln Ala Asp Glu Met 
    130                 135                 140                 


Glu Arg Tyr Val Glu Glu Asn Gln Thr Arg Asp Lys His Leu Asn Pro 
145                 150                 155                 160 


Asn Glu Trp Trp Lys Val Tyr Pro Ser Ser Val Thr Glu Phe Lys Phe 
                165                 170                 175     


Leu Phe Val Ser Gly His Phe Lys Gly Asn Tyr Lys Ala Gln Leu Thr 
            180                 185                 190         


Arg Leu Asn His Ile Thr Asn Cys Asn Gly Ala Val Leu Ser Val Glu 
        195                 200                 205             


Glu Leu Leu Ile Gly Gly Glu Met Ile Lys Ala Gly Thr Leu Thr Leu 
    210                 215                 220                 


Glu Glu Val Arg Arg Lys Phe Asn Asn Gly Glu Ile Asn Phe Ser Gly 
225                 230                 235                 240 


Thr Pro His Glu Val Gly Val Tyr Thr Leu Arg Pro Phe Gln Cys Arg 
                245                 250                 255     


Ile Cys Met Arg Asn Phe Ser Arg Ser Asp His Leu Ser Arg His Ile 
            260                 265                 270         


Arg Thr His Thr Gly Glu Lys Pro Phe Ala Cys Asp Ile Cys Gly Arg 
        275                 280                 285             


Lys Phe Ala Asp Ser Ser Asp Arg Lys Lys His Thr Lys Ile His Thr 
    290                 295                 300                 


Gly Glu Lys Pro Phe Gln Cys Arg Ile Cys Met Arg Asn Phe Ser Arg 
305                 310                 315                 320 


Ser Asp Thr Leu Ser Glu His Ile Arg Thr His Thr Gly Glu Lys Pro 
                325                 330                 335     


Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Gln Ser Gly Asp Leu 
            340                 345                 350         


Thr Arg His Thr Lys Ile His Thr His Pro Arg Ala Pro Ile Pro Lys 
        355                 360                 365             


Pro Phe Gln Cys Arg Ile Cys Met Arg Asn Phe Ser Gln Ser Ser Asp 
    370                 375                 380                 


Leu Ser Arg His Ile Arg Thr His Thr Gly Glu Lys Pro Phe Ala Cys 
385                 390                 395                 400 


Asp Ile Cys Gly Arg Lys Phe Ala Tyr Lys Trp Thr Leu Arg Asn His 
                405                 410                 415     


Thr Lys Ile His Leu Arg Gln Lys Asp 
            420                 425 


<210>  8
<211>  392
<212>  PRT
<213>  artificial sequence

<220>
<223>  zinc finger nuclease 84221

<400>  8

Met Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp 
1               5                   10                  15      


Tyr Lys Asp Asp Asp Asp Lys Met Ala Pro Lys Lys Lys Arg Lys Val 
            20                  25                  30          


Gly Ile His Gly Val Pro Ala Ala Met Gly Gln Leu Val Lys Ser Glu 
        35                  40                  45              


Leu Glu Glu Lys Lys Ser Glu Leu Arg His Lys Leu Lys Tyr Val Pro 
    50                  55                  60                  


His Glu Tyr Ile Glu Leu Ile Glu Ile Ala Arg Asn Ser Thr Gln Asp 
65                  70                  75                  80  


Arg Ile Leu Glu Met Lys Val Met Glu Phe Phe Met Lys Val Tyr Gly 
                85                  90                  95      


Tyr Arg Gly Lys His Leu Gly Gly Ser Arg Lys Pro Asp Gly Ala Ile 
            100                 105                 110         


Tyr Thr Val Gly Ser Pro Ile Asp Tyr Gly Val Ile Val Asp Thr Lys 
        115                 120                 125             


Ala Tyr Ser Gly Gly Tyr Asn Leu Pro Ile Gly Gln Ala Asp Glu Met 
    130                 135                 140                 


Gln Arg Tyr Val Lys Glu Asn Gln Thr Arg Asn Lys His Ile Asn Pro 
145                 150                 155                 160 


Asn Glu Trp Trp Lys Val Tyr Pro Ser Ser Val Thr Glu Phe Lys Phe 
                165                 170                 175     


Leu Phe Val Ser Gly His Phe Lys Gly Asn Tyr Lys Ala Gln Leu Thr 
            180                 185                 190         


Arg Leu Asn Arg Lys Thr Asn Cys Asn Gly Ala Val Leu Ser Val Glu 
        195                 200                 205             


Glu Leu Leu Ile Gly Gly Glu Met Ile Lys Ala Gly Thr Leu Thr Leu 
    210                 215                 220                 


Glu Glu Val Arg Arg Lys Phe Asn Asn Gly Glu Ile Asn Phe Ser Gly 
225                 230                 235                 240 


Thr Pro His Glu Val Gly Val Tyr Thr Leu Arg Pro Phe Gln Cys Arg 
                245                 250                 255     


Ile Cys Met Arg Asn Phe Ser Ser Asn Gln Asn Leu Thr Thr His Ile 
            260                 265                 270         


Arg Thr His Thr Gly Glu Lys Pro Phe Ala Cys Asp Ile Cys Gly Arg 
        275                 280                 285             


Lys Phe Ala Asp Arg Ser His Leu Ala Arg His Thr Lys Ile His Thr 
    290                 295                 300                 


Gly Glu Lys Pro Phe Gln Cys Arg Ile Cys Met Gln Lys Phe Ala Gln 
305                 310                 315                 320 


Ser Gly Asp Leu Thr Arg His Thr Lys Ile His Thr Gly Glu Lys Pro 
                325                 330                 335     


Phe Gln Cys Arg Ile Cys Met Gln Asn Phe Ser Trp Lys His Asp Leu 
            340                 345                 350         


Thr Asn His Ile Arg Thr His Thr Gly Glu Lys Pro Phe Ala Cys Asp 
        355                 360                 365             


Ile Cys Gly Arg Lys Phe Ala Thr Ser Gly Asn Leu Thr Arg His Thr 
    370                 375                 380                 


Lys Ile His Leu Arg Gln Lys Asp 
385                 390         


<210>  9
<211>  15
<212>  DNA
<213>  artificial sequence

<220>
<223>  dna binding sequence of ZFP 76867

<400>  9
gccaccatgg agttg                                                        15


<210>  10
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  ZFP 76867 Finger 1

<400>  10

Arg Pro Tyr Thr Leu Arg Leu 
1               5           


<210>  11
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  ZFP 76867 Finger 2

<400>  11

Arg Ser Ala Asn Leu Thr Arg 
1               5           


<210>  12
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  ZFP 76867 Finger 3

<400>  12

Arg Ser Asp Ala Leu Ser Thr 
1               5           


<210>  13
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  ZFP 76867 Finger 4

<400>  13

Asp Arg Ser Thr Arg Thr Lys 
1               5           


<210>  14
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  ZFP 76867 Finger 5

<400>  14

Asp Arg Ser Thr Arg Thr Lys 
1               5           


<210>  15
<211>  18
<212>  DNA
<213>  artificial sequence

<220>
<223>  dna binding sequence of ZFP 82862

<400>  15
ctagaaggtg gctacctg                                                     18


<210>  16
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  ZFP 82862 Finger 1

<400>  16

Arg Ser Asp Val Leu Ser Ala 
1               5           


<210>  17
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  ZFP 82862 Finger 2

<400>  17

Asp Arg Ser Asn Arg Ile Lys 
1               5           


<210>  18
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  ZFP 82862 Finger 3

<400>  18

Asp Arg Ser His Leu Thr Arg 
1               5           


<210>  19
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  ZFP 82862 Finger 4

<400>  19

Leu Lys Gln His Leu Thr Arg 
1               5           


<210>  20
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  ZFP 82862 Finger 5

<400>  20

Gln Ser Gly Asn Leu Ala Arg 
1               5           


<210>  21
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  ZFP 82862 Finger 6

<400>  21

Gln Ser Thr Pro Arg Thr Thr 
1               5           


<210>  22
<211>  12
<212>  DNA
<213>  artificial sequence

<220>
<223>  dna binding sequence of ZFP 87254

<400>  22
gaaccgtccg gg                                                           12


<210>  23
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  ZFP 87254 Finger 1

<400>  23

Arg Ser Asp His Leu Ser Arg 
1               5           


<210>  24
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  ZFP 87254 Finger 2

<400>  24

Asp Ser Ser Asp Arg Lys Lys 
1               5           


<210>  25
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  ZFP 87254 Finger 3

<400>  25

Arg Ser Asp Thr Leu Ser Glu 
1               5           


<210>  26
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  ZFP 87254 Finger 4

<400>  26

Gln Ser Gly Asp Leu Thr Arg 
1               5           


<210>  27
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  ZFP 87254 Finger 5

<400>  27

Gln Ser Ser Asp Leu Ser Arg 
1               5           


<210>  28
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  ZFP 87254 Finger 6

<400>  28

Tyr Lys Trp Thr Leu Arg Asn 
1               5           


<210>  29
<211>  15
<212>  DNA
<213>  artificial sequence

<220>
<223>  dna binding sequence of ZFP 84221

<400>  29
gatcctgcag gccat                                                        15


<210>  30
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  ZFP 84221 Finger 1

<400>  30

Ser Asn Gln Asn Leu Thr Thr 
1               5           


<210>  31
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  ZFP 84221 Finger 2

<400>  31

Asp Arg Ser His Leu Ala Arg 
1               5           


<210>  32
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  ZFP 84221 Finger 3

<400>  32

Gln Ser Gly Asp Leu Thr Arg 
1               5           


<210>  33
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  ZFP 84221 Finger 4

<400>  33

Trp Lys His Asp Leu Thr Asn 
1               5           


<210>  34
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  ZFP 84221 Finger 5

<400>  34

Thr Ser Gly Asn Leu Thr Arg 
1               5           


<210>  35
<211>  579
<212>  PRT
<213>  artificial sequence

<220>
<223>  FokI protein

<400>  35

Met Val Ser Lys Ile Arg Thr Phe Gly Trp Val Gln Asn Pro Gly Lys 
1               5                   10                  15      


Phe Glu Asn Leu Lys Arg Val Val Gln Val Phe Asp Arg Asn Ser Lys 
            20                  25                  30          


Val His Asn Glu Val Lys Asn Ile Lys Ile Pro Thr Leu Val Lys Glu 
        35                  40                  45              


Ser Lys Ile Gln Lys Glu Leu Val Ala Ile Met Asn Gln His Asp Leu 
    50                  55                  60                  


Ile Tyr Thr Tyr Lys Glu Leu Val Gly Thr Gly Thr Ser Ile Arg Ser 
65                  70                  75                  80  


Glu Ala Pro Cys Asp Ala Ile Ile Gln Ala Thr Ile Ala Asp Gln Gly 
                85                  90                  95      


Asn Lys Lys Gly Tyr Ile Asp Asn Trp Ser Ser Asp Gly Phe Leu Arg 
            100                 105                 110         


Trp Ala His Ala Leu Gly Phe Ile Glu Tyr Ile Asn Lys Ser Asp Ser 
        115                 120                 125             


Phe Val Ile Thr Asp Val Gly Leu Ala Tyr Ser Lys Ser Ala Asp Gly 
    130                 135                 140                 


Ser Ala Ile Glu Lys Glu Ile Leu Ile Glu Ala Ile Ser Ser Tyr Pro 
145                 150                 155                 160 


Pro Ala Ile Arg Ile Leu Thr Leu Leu Glu Asp Gly Gln His Leu Thr 
                165                 170                 175     


Lys Phe Asp Leu Gly Lys Asn Leu Gly Phe Ser Gly Glu Ser Gly Phe 
            180                 185                 190         


Thr Ser Leu Pro Glu Gly Ile Leu Leu Asp Thr Leu Ala Asn Ala Met 
        195                 200                 205             


Pro Lys Asp Lys Gly Glu Ile Arg Asn Asn Trp Glu Gly Ser Ser Asp 
    210                 215                 220                 


Lys Tyr Ala Arg Met Ile Gly Gly Trp Leu Asp Lys Leu Gly Leu Val 
225                 230                 235                 240 


Lys Gln Gly Lys Lys Glu Phe Ile Ile Pro Thr Leu Gly Lys Pro Asp 
                245                 250                 255     


Asn Lys Glu Phe Ile Ser His Ala Phe Lys Ile Thr Gly Glu Gly Leu 
            260                 265                 270         


Lys Val Leu Arg Arg Ala Lys Gly Ser Thr Lys Phe Thr Arg Val Pro 
        275                 280                 285             


Lys Arg Val Tyr Trp Glu Met Leu Ala Thr Asn Leu Thr Asp Lys Glu 
    290                 295                 300                 


Tyr Val Arg Thr Arg Arg Ala Leu Ile Leu Glu Ile Leu Ile Lys Ala 
305                 310                 315                 320 


Gly Ser Leu Lys Ile Glu Gln Ile Gln Asp Asn Leu Lys Lys Leu Gly 
                325                 330                 335     


Phe Asp Glu Val Ile Glu Thr Ile Glu Asn Asp Ile Lys Gly Leu Ile 
            340                 345                 350         


Asn Thr Gly Ile Phe Ile Glu Ile Lys Gly Arg Phe Tyr Gln Leu Lys 
        355                 360                 365             


Asp His Ile Leu Gln Phe Val Ile Pro Asn Arg Gly Val Thr Lys Gln 
    370                 375                 380                 


Leu Val Lys Ser Glu Leu Glu Glu Lys Lys Ser Glu Leu Arg His Lys 
385                 390                 395                 400 


Leu Lys Tyr Val Pro His Glu Tyr Ile Glu Leu Ile Glu Ile Ala Arg 
                405                 410                 415     


Asn Ser Thr Gln Asp Arg Ile Leu Glu Met Lys Val Met Glu Phe Phe 
            420                 425                 430         


Met Lys Val Tyr Gly Tyr Arg Gly Lys His Leu Gly Gly Ser Arg Lys 
        435                 440                 445             


Pro Asp Gly Ala Ile Tyr Thr Val Gly Ser Pro Ile Asp Tyr Gly Val 
    450                 455                 460                 


Ile Val Asp Thr Lys Ala Tyr Ser Gly Gly Tyr Asn Leu Pro Ile Gly 
465                 470                 475                 480 


Gln Ala Asp Glu Met Gln Arg Tyr Val Glu Glu Asn Gln Thr Arg Asn 
                485                 490                 495     


Lys His Ile Asn Pro Asn Glu Trp Trp Lys Val Tyr Pro Ser Ser Val 
            500                 505                 510         


Thr Glu Phe Lys Phe Leu Phe Val Ser Gly His Phe Lys Gly Asn Tyr 
        515                 520                 525             


Lys Ala Gln Leu Thr Arg Leu Asn His Ile Thr Asn Cys Asn Gly Ala 
    530                 535                 540                 


Val Leu Ser Val Glu Glu Leu Leu Ile Gly Gly Glu Met Ile Lys Ala 
545                 550                 555                 560 


Gly Thr Leu Thr Leu Glu Glu Val Arg Arg Lys Phe Asn Asn Gly Glu 
                565                 570                 575     


Ile Asn Phe 
            


<210>  36
<211>  196
<212>  PRT
<213>  artificial sequence

<220>
<223>  FokIELD protein

<400>  36

Gln Leu Val Lys Ser Glu Leu Glu Glu Lys Lys Ser Glu Leu Arg His 
1               5                   10                  15      


Lys Leu Lys Tyr Val Pro His Glu Tyr Ile Glu Leu Ile Glu Ile Ala 
            20                  25                  30          


Arg Asn Ser Thr Gln Asp Arg Ile Leu Glu Met Lys Val Met Glu Phe 
        35                  40                  45              


Phe Met Lys Val Tyr Gly Tyr Arg Gly Lys His Leu Gly Gly Ser Arg 
    50                  55                  60                  


Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly Ser Pro Ile Asp Tyr Gly 
65                  70                  75                  80  


Val Ile Val Asp Thr Lys Ala Tyr Ser Gly Gly Tyr Asn Leu Pro Ile 
                85                  90                  95      


Gly Gln Ala Asp Glu Met Glu Arg Tyr Val Glu Glu Asn Gln Thr Arg 
            100                 105                 110         


Asp Lys His Leu Asn Pro Asn Glu Trp Trp Lys Val Tyr Pro Ser Ser 
        115                 120                 125             


Val Thr Glu Phe Lys Phe Leu Phe Val Ser Gly His Phe Lys Gly Asn 
    130                 135                 140                 


Tyr Lys Ala Gln Leu Thr Arg Leu Asn His Ile Thr Asn Cys Asn Gly 
145                 150                 155                 160 


Ala Val Leu Ser Val Glu Glu Leu Leu Ile Gly Gly Glu Met Ile Lys 
                165                 170                 175     


Ala Gly Thr Leu Thr Leu Glu Glu Val Arg Arg Lys Phe Asn Asn Gly 
            180                 185                 190         


Glu Ile Asn Phe 
        195     


<210>  37
<211>  196
<212>  PRT
<213>  artificial sequence

<220>
<223>  FokIKKR protein

<400>  37

Gln Leu Val Lys Ser Glu Leu Glu Glu Lys Lys Ser Glu Leu Arg His 
1               5                   10                  15      


Lys Leu Lys Tyr Val Pro His Glu Tyr Ile Glu Leu Ile Glu Ile Ala 
            20                  25                  30          


Arg Asn Ser Thr Gln Asp Arg Ile Leu Glu Met Lys Val Met Glu Phe 
        35                  40                  45              


Phe Met Lys Val Tyr Gly Tyr Arg Gly Lys His Leu Gly Gly Ser Arg 
    50                  55                  60                  


Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly Ser Pro Ile Asp Tyr Gly 
65                  70                  75                  80  


Val Ile Val Asp Thr Lys Ala Tyr Ser Gly Gly Tyr Asn Leu Pro Ile 
                85                  90                  95      


Gly Gln Ala Asp Glu Met Gln Arg Tyr Val Lys Glu Asn Gln Thr Arg 
            100                 105                 110         


Asn Lys His Ile Asn Pro Asn Glu Trp Trp Lys Val Tyr Pro Ser Ser 
        115                 120                 125             


Val Thr Glu Phe Lys Phe Leu Phe Val Ser Gly His Phe Lys Gly Asn 
    130                 135                 140                 


Tyr Lys Ala Gln Leu Thr Arg Leu Asn Arg Lys Thr Asn Cys Asn Gly 
145                 150                 155                 160 


Ala Val Leu Ser Val Glu Glu Leu Leu Ile Gly Gly Glu Met Ile Lys 
                165                 170                 175     


Ala Gly Thr Leu Thr Leu Glu Glu Val Arg Arg Lys Phe Asn Asn Gly 
            180                 185                 190         


Glu Ile Asn Phe 
        195     


<210>  38
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  dna binding sequence of ZFP 87254

<400>  38
attgcttgaa ccgtccggg                                                    19


<210>  39
<211>  5620
<212>  DNA
<213>  artificial sequence

<220>
<223>  STV220-pVAX-GEM2UX-CIITA-B-76867-2A-82862 plasmid

<400>  39
gctgcttcgc gatgtacggg ccagatatac gcgcatgttc tttcctgcgt tatcccctga       60

ttctgtggat aaccgtatta ccgcctttga gtgagctgat accgctcgcc gcagccgaac      120

gaccgagcgc agcgagtcag tgagcgagga agcggaagag cgcccaatac gcaaaccgcc      180

tctccccgcg cgttggccga ttcattaatg cagctggcac gacaggtttc ccgactggaa      240

agcgggcagt gagcgcaacg caattaatgt gagttagctc actcattagg caccccaggc      300

tttacacttt atgcttccgg ctcgtatgtt gtgtggaatt gtgagcggat aacaatttca      360

cacaggaaac agctatgacc atgattacgc caagctctaa tacgactcac tatagggaga      420

caagcttgaa tacaagcttg cttgttcttt ttgcagaagc tcagaataaa cgctcaactt      480

tggcagatcg aattcgccat ggactacaaa gaccatgacg gtgattataa agatcatgac      540

atcgattaca aggatgacga tgacaagatg gcccccaaga agaagaggaa ggtcggcatc      600

cacggggtac ccgccgctat gggacagctg gtgaagagcg agctggagga gaagaagtcc      660

gagctgcggc acaagctgaa gtacgtgccc cacgagtaca tcgagctgat cgagatcgcc      720

aggaacagca cccaggaccg catcctggag atgaaggtga tggagttctt catgaaggtg      780

tacggctaca ggggaaagca cctgggcgga agcagaaagc ctgacggcgc catctataca      840

gtgggcagcc ccatcgatta cggcgtgatc gtggacacaa aggcctacag cggcggctac      900

aatctgccta tcggccaggc cgacgagatg gagagatacg tggaggagaa ccagacccgg      960

gataagcacc tcaaccccaa cgagtggtgg aaggtgtacc ctagcagcgt gaccgagttc     1020

aagttcctgt tcgtgagcgg ccacttcaag ggcaactaca aggcccagct gaccaggctg     1080

aaccacatca ccaactgcaa tggcgccgtg ctgagcgtgg aggagctgct gatcggcggc     1140

gagatgatca aagccggcac cctgacactg gaggaggtgc ggcgcaagtt caacaacggc     1200

gagatcaact tcagcggcgc tcagggatct accctggact ttaggccctt ccagtgtcga     1260

atctgcatgc gtaacttcag tcgcccgtac accctgcgcc tgcacatccg cacccacacc     1320

ggcgagaagc cttttgcctg tgacatttgt gggaggaaat ttgcccgctc cgccaacctg     1380

acccgccata ccaagataca cacgggcagc caaaagccct tccagtgtcg aatctgcatg     1440

cgtaacttca gtcgtagtga cgccctgagc acgcacatcc gcacccacac aggcgagaag     1500

ccttttgcct gtgacatttg tgggaggaaa tttgccgaca ggagcacccg cacaaagcat     1560

accaagatac acacgggcga gaagcccttc cagtgtcgaa tctgcatgcg taagtttgcc     1620

gaccgctcca cccgcaccaa gcataccaag atacacctgc ggcagaagga cagatctggc     1680

ggcggagagg gcagaggaag tcttctaacc tgcggtgacg tggaggagaa tcccggccct     1740

aggaccatgg actacaaaga ccatgacggt gattataaag atcatgacat cgattacaag     1800

gatgacgatg acaagatggc ccccaagaag aagaggaagg tcggcattca tggggtaccc     1860

gccgctatgg ctgagaggcc cttccagtgt cgaatctgca tgcagaactt cagtcgtagt     1920

gacgtcctga gcgcacacat ccgcacccac acaggcgaga agccttttgc ctgtgacatt     1980

tgtgggaaga aatttgccga caggagcaac cgcataaagc ataccaagat acacacgggc     2040

agccaaaagc ccttccagtg tcgaatctgc atgcagaact tcagtgaccg ctcccacctg     2100

acccgccaca tccgcaccca caccggcgag aagccttttg cctgtgacat ttgtgggagg     2160

aaatttgccc tgaagcagca cctgacccgc cataccaaga tacacacggg cgagaagccc     2220

ttccagtgtc gaatctgcat gcagaacttc agtcagtccg gcaacctggc ccgccacatc     2280

cgcacccaca ccggcgagaa gccttttgcc tgtgacattt gtgggaggaa atttgcccag     2340

tccaccccgc gcaccaccca taccaagata cacctgcggg gatcccagct ggtgaagagc     2400

gagctggagg agaagaagtc cgagctgcgg cacaagctga agtacgtgcc ccacgagtac     2460

atcgagctga tcgagatcgc caggaacagc acccaggacc gcatcctgga gatgaaggtg     2520

atggagttct tcatgaaggt gtacggctac aggggaaagc acctgggcgg aagcagaaag     2580

cctgacggcg ccatctatac agtgggcagc cccatcgatt acggcgtgat cgtggacaca     2640

aaggcctaca gcggcggcta caatctgcct atcggccagg ccgacgagat gcagagatac     2700

gtgaaggaga accagacccg gaataagcac atcaacccca acgagtggtg gaaggtgtac     2760

cctagcagcg tgaccgagtt caagttcctg ttcgtgagcg gccacttcaa gggcaactac     2820

aaggcccagc tgaccaggct gaaccgcaaa accaactgca atggcgccgt gctgagcgtg     2880

gaggagctgc tgatcggcgg cgagatgatc aaagccggca ccctgacact ggaggaggtg     2940

cggcgcaagt tcaacaacgg cgagatcaac ttctgataac tcgagtctag aagctcgctt     3000

tcttgctgtc caatttctat taaaggttcc tttgttccct aagtccaact actaaactgg     3060

gggatattat gaagggcctt gagcatctgg attctgccta ataaaaaaca tttattttca     3120

ttgctgcgct agaagctcgc tttcttgctg tccaatttct attaaaggtt cctttgttcc     3180

ctaagtccaa ctactaaact gggggatatt atgaagggcc ttgagcatct ggattctgcc     3240

taataaaaaa catttatttt cattgctgcg ggacattctt aattaaaaaa aaaaaaaaaa     3300

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaactagtg gcgcctgatg     3360

cggtattttc tccttacgca tctgtgcggt atttcacacc gcataatcca gcacagtggc     3420

ggcccgttta aacccgctga tcagcctcga ctgtgccttc tagttgccag ccatctgttg     3480

tttgcccctc ccccgtgcct tccttgaccc tggaaggtgc cactcccact gtcctttcct     3540

aataaaatga ggaaattgca tcgcattgtc tgagtaggtg tcattctatt ctggggggtg     3600

gggtggggca ggacagcaag ggggaggatt gggaagacaa tagcaggcat gctggggatg     3660

cggtgggctc tatggcttct actgggcggt tttatggaca gcaagcgaac cggaattgcc     3720

agctggggcg ccctctggta aggttgggaa gccctgcaaa gtaaactgga tggctttctt     3780

gccgccaagg atctgatggc gcaggggatc aagctctgat caagagacag gatgaggatc     3840

gtttcgcatg attgaacaag atggattgca cgcaggttct ccggccgctt gggtggagag     3900

gctattcggc tatgactggg cacaacagac aatcggctgc tctgatgccg ccgtgttccg     3960

gctgtcagcg caggggcgcc cggttctttt tgtcaagacc gacctgtccg gtgccctgaa     4020

tgaactgcaa gacgaggcag cgcggctatc gtggctggcc acgacgggcg ttccttgcgc     4080

agctgtgctc gacgttgtca ctgaagcggg aagggactgg ctgctattgg gcgaagtgcc     4140

ggggcaggat ctcctgtcat ctcaccttgc tcctgccgag aaagtatcca tcatggctga     4200

tgcaatgcgg cggctgcata cgcttgatcc ggctacctgc ccattcgacc accaagcgaa     4260

acatcgcatc gagcgagcac gtactcggat ggaagccggt cttgtcgatc aggatgatct     4320

ggacgaagag catcaggggc tcgcgccagc cgaactgttc gccaggctca aggcgagcat     4380

gcccgacggc gaggatctcg tcgtgaccca tggcgatgcc tgcttgccga atatcatggt     4440

ggaaaatggc cgcttttctg gattcatcga ctgtggccgg ctgggtgtgg cggaccgcta     4500

tcaggacata gcgttggcta cccgtgatat tgctgaagag cttggcggcg aatgggctga     4560

ccgcttcctc gtgctttacg gtatcgccgc tcccgattcg cagcgcatcg ccttctatcg     4620

ccttcttgac gagttcttct gaattattaa cgcttacaat ttcctgatgc ggtattttct     4680

ccttacgcat ctgtgcggta tttcacaccg catcaggtgg cacttttcgg ggaaatgtgc     4740

gcggaacccc tatttgttta tttttctaaa tacattcaaa tatgtatccg ctcatgagac     4800

aataaccctg ataaatgctt caataatagc acgtgctaaa acttcatttt taatttaaaa     4860

ggatctaggt gaagatcctt tttgataatc tcatgaccaa aatcccttaa cgtgagtttt     4920

cgttccactg agcgtcagac cccgtagaaa agatcaaagg atcttcttga gatccttttt     4980

ttctgcgcgt aatctgctgc ttgcaaacaa aaaaaccacc gctaccagcg gtggtttgtt     5040

tgccggatca agagctacca actctttttc cgaaggtaac tggcttcagc agagcgcaga     5100

taccaaatac tgttcttcta gtgtagccgt agttaggcca ccacttcaag aactctgtag     5160

caccgcctac atacctcgct ctgctaatcc tgttaccagt ggctgctgcc agtggcgata     5220

agtcgtgtct taccgggttg gactcaagac gatagttacc ggataaggcg cagcggtcgg     5280

gctgaacggg gggttcgtgc acacagccca gcttggagcg aacgacctac accgaactga     5340

gatacctaca gcgtgagcta tgagaaagcg ccacgcttcc cgaagggaga aaggcggaca     5400

ggtatccggt aagcggcagg gtcggaacag gagagcgcac gagggagctt ccagggggaa     5460

acgcctggta tctttatagt cctgtcgggt ttcgccacct ctgacttgag cgtcgatttt     5520

tgtgatgctc gtcagggggg cggagcctat ggaaaaacgc cagcaacgcg gcctttttac     5580

ggttcctggc cttttgctgg ccttttgctc acatgttctt                           5620


<210>  40
<211>  5671
<212>  DNA
<213>  artificial sequence

<220>
<223>  STV220-pVAX-GEM2UX-CIITA-G-87254-2A-84221 plasmid

<400>  40
gctgcttcgc gatgtacggg ccagatatac gcgcatgttc tttcctgcgt tatcccctga       60

ttctgtggat aaccgtatta ccgcctttga gtgagctgat accgctcgcc gcagccgaac      120

gaccgagcgc agcgagtcag tgagcgagga agcggaagag cgcccaatac gcaaaccgcc      180

tctccccgcg cgttggccga ttcattaatg cagctggcac gacaggtttc ccgactggaa      240

agcgggcagt gagcgcaacg caattaatgt gagttagctc actcattagg caccccaggc      300

tttacacttt atgcttccgg ctcgtatgtt gtgtggaatt gtgagcggat aacaatttca      360

cacaggaaac agctatgacc atgattacgc caagctctaa tacgactcac tatagggaga      420

caagcttgaa tacaagcttg cttgttcttt ttgcagaagc tcagaataaa cgctcaactt      480

tggcagatcg aattcgccat ggactacaaa gaccatgacg gtgattataa agatcatgac      540

atcgattaca aggatgacga tgacaagatg gcccccaaga agaagaggaa ggtcggcatc      600

cacggggtac ccgccgctat gggacagctg gtgaagagcg agctggagga gaagaagtcc      660

gagctgcggc acaagctgaa gtacgtgccc cacgagtaca tcgagctgat cgagatcgcc      720

aggaacagca cccaggaccg catcctggag atgaaggtga tggagttctt catgaaggtg      780

tacggctaca ggggaaagca cctgggcgga agcagaaagc ctgacggcgc catctataca      840

gtgggcagcc ccatcgatta cggcgtgatc gtggacacaa aggcctacag cggcggctac      900

aatctgccta tcggccaggc cgacgagatg gagagatacg tggaggagaa ccagacccgg      960

gataagcacc tcaaccccaa cgagtggtgg aaggtgtacc ctagcagcgt gaccgagttc     1020

aagttcctgt tcgtgagcgg ccacttcaag ggcaactaca aggcccagct gaccaggctg     1080

aaccacatca ccaactgcaa tggcgccgtg ctgagcgtgg aggagctgct gatcggcggc     1140

gagatgatca aagccggcac cctgacactg gaggaggtgc ggcgcaagtt caacaacggc     1200

gagatcaact tcagcggcac tccacacgaa gtgggagtgt acacacttag gcccttccag     1260

tgtcgaatct gcatgcgtaa cttcagtcgt agtgaccacc tgagccggca catccgcacc     1320

cacacaggcg agaagccttt tgcctgtgac atttgtggga ggaaatttgc cgacagcagc     1380

gaccgcaaaa agcataccaa gatacacacg ggcgagaagc ccttccagtg tcgaatctgc     1440

atgcgtaact tcagtcgctc cgacaccctg tccgagcaca tccgcaccca caccggcgag     1500

aagccttttg cctgtgacat ttgtgggagg aaatttgccc agtccggcga cctgacccgc     1560

cataccaaga tacacacgca cccgcgcgcc ccgatcccga agcccttcca gtgtcgaatc     1620

tgcatgcgta acttcagtca gtcctccgac ctgtcccgcc acatccgcac ccacaccggc     1680

gagaagcctt ttgcctgtga catttgtggg aggaaatttg cctacaagtg gaccctgcgc     1740

aaccatacca agatacacct gcggcagaag gacagatctg gcggcggaga gggcagagga     1800

agtcttctaa cctgcggtga cgtggaggag aatcccggcc ctaggaccat ggactacaaa     1860

gaccatgacg gtgattataa agatcatgac atcgattaca aggatgacga tgacaagatg     1920

gcccccaaga agaagaggaa ggtcggcatt catggggtac ccgccgctat gggacagctg     1980

gtgaagagcg agctggagga gaagaagtcc gagctgcggc acaagctgaa gtacgtgccc     2040

cacgagtaca tcgagctgat cgagatcgcc aggaacagca cccaggaccg catcctggag     2100

atgaaggtga tggagttctt catgaaggtg tacggctaca ggggaaagca cctgggcgga     2160

agcagaaagc ctgacggcgc catctataca gtgggcagcc ccatcgatta cggcgtgatc     2220

gtggacacaa aggcctacag cggcggctac aatctgccta tcggccaggc cgacgagatg     2280

cagagatacg tgaaggagaa ccagacccgg aataagcaca tcaaccccaa cgagtggtgg     2340

aaggtgtacc ctagcagcgt gaccgagttc aagttcctgt tcgtgagcgg ccacttcaag     2400

ggcaactaca aggcccagct gaccaggctg aaccgcaaaa ccaactgcaa tggcgccgtg     2460

ctgagcgtgg aggagctgct gatcggcggc gagatgatca aagccggcac cctgacactg     2520

gaggaggtgc ggcgcaagtt caacaacggc gagatcaact tcagcggcac tccacacgaa     2580

gtgggagtgt acacacttag gcccttccag tgtcgaatct gcatgcgtaa cttcagttcc     2640

aaccagaacc tgaccaccca catccgcacc cacaccggcg agaagccttt tgcctgtgac     2700

atttgtggga ggaaatttgc cgaccgctcc cacctggccc gccataccaa gatacacacg     2760

ggcgagaagc ccttccagtg tcgaatctgc atgcagaagt ttgcccagtc cggcgacctg     2820

acccgccata ccaagataca cacgggcgag aagcccttcc agtgtcgaat ctgcatgcag     2880

aacttcagtt ggaagcacga cctgaccaac cacatccgca cccacaccgg cgagaagcct     2940

tttgcctgtg acatttgtgg gaggaaattt gccacctccg gcaacctgac ccgccatacc     3000

aagatacacc tgcggcagaa ggactgataa ctcgagtcta gaagctcgct ttcttgctgt     3060

ccaatttcta ttaaaggttc ctttgttccc taagtccaac tactaaactg ggggatatta     3120

tgaagggcct tgagcatctg gattctgcct aataaaaaac atttattttc attgctgcgc     3180

tagaagctcg ctttcttgct gtccaatttc tattaaaggt tcctttgttc cctaagtcca     3240

actactaaac tgggggatat tatgaagggc cttgagcatc tggattctgc ctaataaaaa     3300

acatttattt tcattgctgc gggacattct taattaaaaa aaaaaaaaaa aaaaaaaaaa     3360

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaactagt ggcgcctgat gcggtatttt     3420

ctccttacgc atctgtgcgg tatttcacac cgcataatcc agcacagtgg cggcccgttt     3480

aaacccgctg atcagcctcg actgtgcctt ctagttgcca gccatctgtt gtttgcccct     3540

cccccgtgcc ttccttgacc ctggaaggtg ccactcccac tgtcctttcc taataaaatg     3600

aggaaattgc atcgcattgt ctgagtaggt gtcattctat tctggggggt ggggtggggc     3660

aggacagcaa gggggaggat tgggaagaca atagcaggca tgctggggat gcggtgggct     3720

ctatggcttc tactgggcgg ttttatggac agcaagcgaa ccggaattgc cagctggggc     3780

gccctctggt aaggttggga agccctgcaa agtaaactgg atggctttct tgccgccaag     3840

gatctgatgg cgcaggggat caagctctga tcaagagaca ggatgaggat cgtttcgcat     3900

gattgaacaa gatggattgc acgcaggttc tccggccgct tgggtggaga ggctattcgg     3960

ctatgactgg gcacaacaga caatcggctg ctctgatgcc gccgtgttcc ggctgtcagc     4020

gcaggggcgc ccggttcttt ttgtcaagac cgacctgtcc ggtgccctga atgaactgca     4080

agacgaggca gcgcggctat cgtggctggc cacgacgggc gttccttgcg cagctgtgct     4140

cgacgttgtc actgaagcgg gaagggactg gctgctattg ggcgaagtgc cggggcagga     4200

tctcctgtca tctcaccttg ctcctgccga gaaagtatcc atcatggctg atgcaatgcg     4260

gcggctgcat acgcttgatc cggctacctg cccattcgac caccaagcga aacatcgcat     4320

cgagcgagca cgtactcgga tggaagccgg tcttgtcgat caggatgatc tggacgaaga     4380

gcatcagggg ctcgcgccag ccgaactgtt cgccaggctc aaggcgagca tgcccgacgg     4440

cgaggatctc gtcgtgaccc atggcgatgc ctgcttgccg aatatcatgg tggaaaatgg     4500

ccgcttttct ggattcatcg actgtggccg gctgggtgtg gcggaccgct atcaggacat     4560

agcgttggct acccgtgata ttgctgaaga gcttggcggc gaatgggctg accgcttcct     4620

cgtgctttac ggtatcgccg ctcccgattc gcagcgcatc gccttctatc gccttcttga     4680

cgagttcttc tgaattatta acgcttacaa tttcctgatg cggtattttc tccttacgca     4740

tctgtgcggt atttcacacc gcatcaggtg gcacttttcg gggaaatgtg cgcggaaccc     4800

ctatttgttt atttttctaa atacattcaa atatgtatcc gctcatgaga caataaccct     4860

gataaatgct tcaataatag cacgtgctaa aacttcattt ttaatttaaa aggatctagg     4920

tgaagatcct ttttgataat ctcatgacca aaatccctta acgtgagttt tcgttccact     4980

gagcgtcaga ccccgtagaa aagatcaaag gatcttcttg agatcctttt tttctgcgcg     5040

taatctgctg cttgcaaaca aaaaaaccac cgctaccagc ggtggtttgt ttgccggatc     5100

aagagctacc aactcttttt ccgaaggtaa ctggcttcag cagagcgcag ataccaaata     5160

ctgttcttct agtgtagccg tagttaggcc accacttcaa gaactctgta gcaccgccta     5220

catacctcgc tctgctaatc ctgttaccag tggctgctgc cagtggcgat aagtcgtgtc     5280

ttaccgggtt ggactcaaga cgatagttac cggataaggc gcagcggtcg ggctgaacgg     5340

ggggttcgtg cacacagccc agcttggagc gaacgaccta caccgaactg agatacctac     5400

agcgtgagct atgagaaagc gccacgcttc ccgaagggag aaaggcggac aggtatccgg     5460

taagcggcag ggtcggaaca ggagagcgca cgagggagct tccaggggga aacgcctggt     5520

atctttatag tcctgtcggg tttcgccacc tctgacttga gcgtcgattt ttgtgatgct     5580

cgtcaggggg gcggagccta tggaaaaacg ccagcaacgc ggccttttta cggttcctgg     5640

ccttttgctg gccttttgct cacatgttct t                                    5671


<210>  41
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  41
gcagagctct ctggctaact agag                                              24


<210>  42
<211>  80
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  42
tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt       60

ctggcaacta gaaggcacag                                                   80


<210>  43
<211>  47
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer


<220>
<221>  misc_feature
<222>  (21)..(24)
<223>  n is a, c, g, or t

<400>  43
acacgacgct cttccgatct nnnngttgta ggtgtcaatt ttctgcc                     47


<210>  44
<211>  42
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  44
gacgtgtgct cttccgatct atctggtcat agaagtggta ga                          42


<210>  45
<211>  46
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer


<220>
<221>  misc_feature
<222>  (21)..(24)
<223>  n is a, c, g, or t

<400>  45
acacgacgct cttccgatct nnnntcccca gtacgacttt gtcttc                      46


<210>  46
<211>  42
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  46
gacgtgtgct cttccgatct tcaagatgtg gctgaaaacc tc                          42


<210>  47
<211>  63
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer


<220>
<221>  misc_feature
<222>  (30)..(37)
<223>  n is a, c, g, or t

<400>  47
aatgatacgg cgaccaccga gatctacacn nnnnnnnaca ctctttccct acacgacgct       60

ctt                                                                     63


<210>  48
<211>  74
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer


<220>
<221>  misc_feature
<222>  (25)..(32)
<223>  n is a, c, g, or t

<400>  48
caagcagaag acggcatacg agatnnnnnn nnatcacgtt gtgactggag ttcagacgtg       60

tgctcttccg atct                                                         74


<210>  49
<211>  413
<212>  PRT
<213>  artificial sequence

<220>
<223>  zinc finger targeting B

<400>  49

Met Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp 
1               5                   10                  15      


Tyr Lys Asp Asp Asp Asp Lys Met Ala Pro Lys Lys Lys Arg Lys Val 
            20                  25                  30          


Gly Ile His Gly Val Pro Ala Ala Met Gly Gln Leu Val Lys Ser Glu 
        35                  40                  45              


Leu Glu Glu Lys Lys Ser Glu Leu Arg His Lys Leu Lys Tyr Val Pro 
    50                  55                  60                  


His Glu Tyr Ile Glu Leu Ile Glu Ile Ala Arg Asn Ser Thr Gln Asp 
65                  70                  75                  80  


Arg Ile Leu Glu Met Lys Val Met Glu Phe Phe Met Lys Val Tyr Gly 
                85                  90                  95      


Tyr Arg Gly Lys His Leu Gly Gly Ser Arg Lys Pro Asp Gly Ala Ile 
            100                 105                 110         


Tyr Thr Val Gly Ser Pro Ile Asp Tyr Gly Val Ile Val Asp Thr Lys 
        115                 120                 125             


Ala Tyr Ser Gly Gly Tyr Asn Leu Pro Ile Gly Gln Ala Asp Glu Met 
    130                 135                 140                 


Glu Arg Tyr Val Glu Glu Asn Gln Thr Arg Asp Lys His Leu Asn Pro 
145                 150                 155                 160 


Asn Glu Trp Trp Lys Val Tyr Pro Ser Ser Val Thr Glu Phe Lys Phe 
                165                 170                 175     


Leu Phe Val Ser Gly His Phe Lys Gly Asn Tyr Lys Ala Gln Leu Thr 
            180                 185                 190         


Arg Leu Asn His Ile Thr Asn Cys Asn Gly Ala Val Leu Ser Val Glu 
        195                 200                 205             


Glu Leu Leu Ile Gly Gly Glu Met Ile Lys Ala Gly Thr Leu Thr Leu 
    210                 215                 220                 


Glu Glu Val Arg Arg Lys Phe Asn Asn Gly Glu Ile Asn Phe Ser Gly 
225                 230                 235                 240 


Ala Gln Gly Ser Thr Leu Asp Phe Arg Pro Phe Gln Cys Arg Ile Cys 
                245                 250                 255     


Met Arg Asn Phe Ser Arg Pro Tyr Thr Leu Arg Leu His Ile Arg Thr 
            260                 265                 270         


His Thr Gly Glu Lys Pro Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe 
        275                 280                 285             


Ala Arg Ser Ala Asn Leu Thr Arg His Thr Lys Ile His Thr Gly Ser 
    290                 295                 300                 


Gln Lys Pro Phe Gln Cys Arg Ile Cys Met Arg Asn Phe Ser Arg Ser 
305                 310                 315                 320 


Asp Ala Leu Ser Thr His Ile Arg Thr His Thr Gly Glu Lys Pro Phe 
                325                 330                 335     


Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Asp Arg Ser Thr Arg Thr 
            340                 345                 350         


Lys His Thr Lys Ile His Thr Gly Glu Lys Pro Phe Gln Cys Arg Ile 
        355                 360                 365             


Cys Met Arg Lys Phe Ala Asp Arg Ser Thr Arg Thr Lys His Thr Lys 
    370                 375                 380                 


Ile His Leu Arg Gln Lys Asp Arg Ser Gly Gly Gly Glu Gly Arg Gly 
385                 390                 395                 400 


Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly 
                405                 410             


<210>  50
<211>  412
<212>  PRT
<213>  artificial sequence

<220>
<223>  zinc finger targeting B

<400>  50

Pro Arg Thr Met Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His 
1               5                   10                  15      


Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys Met Ala Pro Lys Lys Lys 
            20                  25                  30          


Arg Lys Val Gly Ile His Gly Val Pro Ala Ala Met Ala Glu Arg Pro 
        35                  40                  45              


Phe Gln Cys Arg Ile Cys Met Gln Asn Phe Ser Arg Ser Asp Val Leu 
    50                  55                  60                  


Ser Ala His Ile Arg Thr His Thr Gly Glu Lys Pro Phe Ala Cys Asp 
65                  70                  75                  80  


Ile Cys Gly Lys Lys Phe Ala Asp Arg Ser Asn Arg Ile Lys His Thr 
                85                  90                  95      


Lys Ile His Thr Gly Ser Gln Lys Pro Phe Gln Cys Arg Ile Cys Met 
            100                 105                 110         


Gln Asn Phe Ser Asp Arg Ser His Leu Thr Arg His Ile Arg Thr His 
        115                 120                 125             


Thr Gly Glu Lys Pro Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala 
    130                 135                 140                 


Leu Lys Gln His Leu Thr Arg His Thr Lys Ile His Thr Gly Glu Lys 
145                 150                 155                 160 


Pro Phe Gln Cys Arg Ile Cys Met Gln Asn Phe Ser Gln Ser Gly Asn 
                165                 170                 175     


Leu Ala Arg His Ile Arg Thr His Thr Gly Glu Lys Pro Phe Ala Cys 
            180                 185                 190         


Asp Ile Cys Gly Arg Lys Phe Ala Gln Ser Thr Pro Arg Thr Thr His 
        195                 200                 205             


Thr Lys Ile His Leu Arg Gly Ser Gln Leu Val Lys Ser Glu Leu Glu 
    210                 215                 220                 


Glu Lys Lys Ser Glu Leu Arg His Lys Leu Lys Tyr Val Pro His Glu 
225                 230                 235                 240 


Tyr Ile Glu Leu Ile Glu Ile Ala Arg Asn Ser Thr Gln Asp Arg Ile 
                245                 250                 255     


Leu Glu Met Lys Val Met Glu Phe Phe Met Lys Val Tyr Gly Tyr Arg 
            260                 265                 270         


Gly Lys His Leu Gly Gly Ser Arg Lys Pro Asp Gly Ala Ile Tyr Thr 
        275                 280                 285             


Val Gly Ser Pro Ile Asp Tyr Gly Val Ile Val Asp Thr Lys Ala Tyr 
    290                 295                 300                 


Ser Gly Gly Tyr Asn Leu Pro Ile Gly Gln Ala Asp Glu Met Gln Arg 
305                 310                 315                 320 


Tyr Val Lys Glu Asn Gln Thr Arg Asn Lys His Ile Asn Pro Asn Glu 
                325                 330                 335     


Trp Trp Lys Val Tyr Pro Ser Ser Val Thr Glu Phe Lys Phe Leu Phe 
            340                 345                 350         


Val Ser Gly His Phe Lys Gly Asn Tyr Lys Ala Gln Leu Thr Arg Leu 
        355                 360                 365             


Asn Arg Lys Thr Asn Cys Asn Gly Ala Val Leu Ser Val Glu Glu Leu 
    370                 375                 380                 


Leu Ile Gly Gly Glu Met Ile Lys Ala Gly Thr Leu Thr Leu Glu Glu 
385                 390                 395                 400 


Val Arg Arg Lys Phe Asn Asn Gly Glu Ile Asn Phe 
                405                 410         


<210>  51
<211>  447
<212>  PRT
<213>  artificial sequence

<220>
<223>  zinc finger targeting G

<400>  51

Met Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp 
1               5                   10                  15      


Tyr Lys Asp Asp Asp Asp Lys Met Ala Pro Lys Lys Lys Arg Lys Val 
            20                  25                  30          


Gly Ile His Gly Val Pro Ala Ala Met Gly Gln Leu Val Lys Ser Glu 
        35                  40                  45              


Leu Glu Glu Lys Lys Ser Glu Leu Arg His Lys Leu Lys Tyr Val Pro 
    50                  55                  60                  


His Glu Tyr Ile Glu Leu Ile Glu Ile Ala Arg Asn Ser Thr Gln Asp 
65                  70                  75                  80  


Arg Ile Leu Glu Met Lys Val Met Glu Phe Phe Met Lys Val Tyr Gly 
                85                  90                  95      


Tyr Arg Gly Lys His Leu Gly Gly Ser Arg Lys Pro Asp Gly Ala Ile 
            100                 105                 110         


Tyr Thr Val Gly Ser Pro Ile Asp Tyr Gly Val Ile Val Asp Thr Lys 
        115                 120                 125             


Ala Tyr Ser Gly Gly Tyr Asn Leu Pro Ile Gly Gln Ala Asp Glu Met 
    130                 135                 140                 


Glu Arg Tyr Val Glu Glu Asn Gln Thr Arg Asp Lys His Leu Asn Pro 
145                 150                 155                 160 


Asn Glu Trp Trp Lys Val Tyr Pro Ser Ser Val Thr Glu Phe Lys Phe 
                165                 170                 175     


Leu Phe Val Ser Gly His Phe Lys Gly Asn Tyr Lys Ala Gln Leu Thr 
            180                 185                 190         


Arg Leu Asn His Ile Thr Asn Cys Asn Gly Ala Val Leu Ser Val Glu 
        195                 200                 205             


Glu Leu Leu Ile Gly Gly Glu Met Ile Lys Ala Gly Thr Leu Thr Leu 
    210                 215                 220                 


Glu Glu Val Arg Arg Lys Phe Asn Asn Gly Glu Ile Asn Phe Ser Gly 
225                 230                 235                 240 


Thr Pro His Glu Val Gly Val Tyr Thr Leu Arg Pro Phe Gln Cys Arg 
                245                 250                 255     


Ile Cys Met Arg Asn Phe Ser Arg Ser Asp His Leu Ser Arg His Ile 
            260                 265                 270         


Arg Thr His Thr Gly Glu Lys Pro Phe Ala Cys Asp Ile Cys Gly Arg 
        275                 280                 285             


Lys Phe Ala Asp Ser Ser Asp Arg Lys Lys His Thr Lys Ile His Thr 
    290                 295                 300                 


Gly Glu Lys Pro Phe Gln Cys Arg Ile Cys Met Arg Asn Phe Ser Arg 
305                 310                 315                 320 


Ser Asp Thr Leu Ser Glu His Ile Arg Thr His Thr Gly Glu Lys Pro 
                325                 330                 335     


Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Gln Ser Gly Asp Leu 
            340                 345                 350         


Thr Arg His Thr Lys Ile His Thr His Pro Arg Ala Pro Ile Pro Lys 
        355                 360                 365             


Pro Phe Gln Cys Arg Ile Cys Met Arg Asn Phe Ser Gln Ser Ser Asp 
    370                 375                 380                 


Leu Ser Arg His Ile Arg Thr His Thr Gly Glu Lys Pro Phe Ala Cys 
385                 390                 395                 400 


Asp Ile Cys Gly Arg Lys Phe Ala Tyr Lys Trp Thr Leu Arg Asn His 
                405                 410                 415     


Thr Lys Ile His Leu Arg Gln Lys Asp Arg Ser Gly Gly Gly Glu Gly 
            420                 425                 430         


Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly 
        435                 440                 445         


<210>  52
<211>  395
<212>  PRT
<213>  artificial sequence

<220>
<223>  zinc finger targeting G

<400>  52

Pro Arg Thr Met Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His 
1               5                   10                  15      


Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys Met Ala Pro Lys Lys Lys 
            20                  25                  30          


Arg Lys Val Gly Ile His Gly Val Pro Ala Ala Met Gly Gln Leu Val 
        35                  40                  45              


Lys Ser Glu Leu Glu Glu Lys Lys Ser Glu Leu Arg His Lys Leu Lys 
    50                  55                  60                  


Tyr Val Pro His Glu Tyr Ile Glu Leu Ile Glu Ile Ala Arg Asn Ser 
65                  70                  75                  80  


Thr Gln Asp Arg Ile Leu Glu Met Lys Val Met Glu Phe Phe Met Lys 
                85                  90                  95      


Val Tyr Gly Tyr Arg Gly Lys His Leu Gly Gly Ser Arg Lys Pro Asp 
            100                 105                 110         


Gly Ala Ile Tyr Thr Val Gly Ser Pro Ile Asp Tyr Gly Val Ile Val 
        115                 120                 125             


Asp Thr Lys Ala Tyr Ser Gly Gly Tyr Asn Leu Pro Ile Gly Gln Ala 
    130                 135                 140                 


Asp Glu Met Gln Arg Tyr Val Lys Glu Asn Gln Thr Arg Asn Lys His 
145                 150                 155                 160 


Ile Asn Pro Asn Glu Trp Trp Lys Val Tyr Pro Ser Ser Val Thr Glu 
                165                 170                 175     


Phe Lys Phe Leu Phe Val Ser Gly His Phe Lys Gly Asn Tyr Lys Ala 
            180                 185                 190         


Gln Leu Thr Arg Leu Asn Arg Lys Thr Asn Cys Asn Gly Ala Val Leu 
        195                 200                 205             


Ser Val Glu Glu Leu Leu Ile Gly Gly Glu Met Ile Lys Ala Gly Thr 
    210                 215                 220                 


Leu Thr Leu Glu Glu Val Arg Arg Lys Phe Asn Asn Gly Glu Ile Asn 
225                 230                 235                 240 


Phe Ser Gly Thr Pro His Glu Val Gly Val Tyr Thr Leu Arg Pro Phe 
                245                 250                 255     


Gln Cys Arg Ile Cys Met Arg Asn Phe Ser Ser Asn Gln Asn Leu Thr 
            260                 265                 270         


Thr His Ile Arg Thr His Thr Gly Glu Lys Pro Phe Ala Cys Asp Ile 
        275                 280                 285             


Cys Gly Arg Lys Phe Ala Asp Arg Ser His Leu Ala Arg His Thr Lys 
    290                 295                 300                 


Ile His Thr Gly Glu Lys Pro Phe Gln Cys Arg Ile Cys Met Gln Lys 
305                 310                 315                 320 


Phe Ala Gln Ser Gly Asp Leu Thr Arg His Thr Lys Ile His Thr Gly 
                325                 330                 335     


Glu Lys Pro Phe Gln Cys Arg Ile Cys Met Gln Asn Phe Ser Trp Lys 
            340                 345                 350         


His Asp Leu Thr Asn His Ile Arg Thr His Thr Gly Glu Lys Pro Phe 
        355                 360                 365             


Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Thr Ser Gly Asn Leu Thr 
    370                 375                 380                 


Arg His Thr Lys Ile His Leu Arg Gln Lys Asp 
385                 390                 395 


<210>  53
<211>  1275
<212>  PRT
<213>  artificial sequence

<220>
<223>  ZFN CIITA 87278 DNA

<400>  53

Ala Thr Gly Gly Ala Cys Thr Ala Cys Ala Ala Ala Gly Ala Cys Cys 
1               5                   10                  15      


Ala Thr Gly Ala Cys Gly Gly Thr Gly Ala Thr Thr Ala Thr Ala Ala 
            20                  25                  30          


Ala Gly Ala Thr Cys Ala Thr Gly Ala Cys Ala Thr Cys Gly Ala Thr 
        35                  40                  45              


Thr Ala Cys Ala Ala Gly Gly Ala Thr Gly Ala Cys Gly Ala Thr Gly 
    50                  55                  60                  


Ala Cys Ala Ala Gly Ala Thr Gly Gly Cys Cys Cys Cys Cys Ala Ala 
65                  70                  75                  80  


Gly Ala Ala Gly Ala Ala Gly Ala Gly Gly Ala Ala Gly Gly Thr Cys 
                85                  90                  95      


Gly Gly Cys Ala Thr Cys Cys Ala Cys Gly Gly Gly Gly Thr Ala Cys 
            100                 105                 110         


Cys Cys Gly Cys Cys Gly Cys Thr Ala Thr Gly Gly Gly Ala Cys Ala 
        115                 120                 125             


Gly Cys Thr Gly Gly Thr Gly Ala Ala Gly Ala Gly Cys Gly Ala Gly 
    130                 135                 140                 


Cys Thr Gly Gly Ala Gly Gly Ala Gly Ala Ala Gly Ala Ala Gly Thr 
145                 150                 155                 160 


Cys Cys Gly Ala Gly Cys Thr Gly Cys Gly Gly Cys Ala Cys Ala Ala 
                165                 170                 175     


Gly Cys Thr Gly Ala Ala Gly Thr Ala Cys Gly Thr Gly Cys Cys Cys 
            180                 185                 190         


Cys Ala Cys Gly Ala Gly Thr Ala Cys Ala Thr Cys Gly Ala Gly Cys 
        195                 200                 205             


Thr Gly Ala Thr Cys Gly Ala Gly Ala Thr Cys Gly Cys Cys Ala Gly 
    210                 215                 220                 


Gly Ala Ala Cys Ala Gly Cys Ala Cys Cys Cys Ala Gly Gly Ala Cys 
225                 230                 235                 240 


Cys Gly Cys Ala Thr Cys Cys Thr Gly Gly Ala Gly Ala Thr Gly Ala 
                245                 250                 255     


Ala Gly Gly Thr Gly Ala Thr Gly Gly Ala Gly Thr Thr Cys Thr Thr 
            260                 265                 270         


Cys Ala Thr Gly Ala Ala Gly Gly Thr Gly Thr Ala Cys Gly Gly Cys 
        275                 280                 285             


Thr Ala Cys Ala Gly Gly Gly Gly Ala Ala Ala Gly Cys Ala Cys Cys 
    290                 295                 300                 


Thr Gly Gly Gly Cys Gly Gly Ala Ala Gly Cys Ala Gly Ala Ala Ala 
305                 310                 315                 320 


Gly Cys Cys Thr Gly Ala Cys Gly Gly Cys Gly Cys Cys Ala Thr Cys 
                325                 330                 335     


Thr Ala Thr Ala Cys Ala Gly Thr Gly Gly Gly Cys Ala Gly Cys Cys 
            340                 345                 350         


Cys Cys Ala Thr Cys Gly Ala Thr Thr Ala Cys Gly Gly Cys Gly Thr 
        355                 360                 365             


Gly Ala Thr Cys Gly Thr Gly Gly Ala Cys Ala Cys Ala Ala Ala Gly 
    370                 375                 380                 


Gly Cys Cys Thr Ala Cys Ala Gly Cys Gly Gly Cys Gly Gly Cys Thr 
385                 390                 395                 400 


Ala Cys Ala Ala Thr Cys Thr Gly Cys Cys Thr Ala Thr Cys Gly Gly 
                405                 410                 415     


Cys Cys Ala Gly Gly Cys Cys Gly Ala Cys Gly Ala Gly Ala Thr Gly 
            420                 425                 430         


Gly Ala Gly Ala Gly Ala Thr Ala Cys Gly Thr Gly Gly Ala Gly Gly 
        435                 440                 445             


Ala Gly Ala Ala Cys Cys Ala Gly Ala Cys Cys Cys Gly Gly Gly Ala 
    450                 455                 460                 


Thr Ala Ala Gly Cys Ala Cys Cys Thr Cys Ala Ala Cys Cys Cys Cys 
465                 470                 475                 480 


Ala Ala Cys Gly Ala Gly Thr Gly Gly Thr Gly Gly Ala Ala Gly Gly 
                485                 490                 495     


Thr Gly Thr Ala Cys Cys Cys Thr Ala Gly Cys Ala Gly Cys Gly Thr 
            500                 505                 510         


Gly Ala Cys Cys Gly Ala Gly Thr Thr Cys Ala Ala Gly Thr Thr Cys 
        515                 520                 525             


Cys Thr Gly Thr Thr Cys Gly Thr Gly Ala Gly Cys Gly Gly Cys Cys 
    530                 535                 540                 


Ala Cys Thr Thr Cys Ala Gly Cys Gly Gly Cys Ala Ala Cys Thr Ala 
545                 550                 555                 560 


Cys Ala Ala Gly Gly Cys Cys Cys Ala Gly Cys Thr Gly Ala Cys Cys 
                565                 570                 575     


Ala Gly Gly Cys Thr Gly Ala Ala Cys Cys Ala Cys Ala Thr Cys Ala 
            580                 585                 590         


Cys Cys Ala Ala Cys Thr Gly Cys Ala Ala Thr Gly Gly Cys Gly Cys 
        595                 600                 605             


Cys Gly Thr Gly Cys Thr Gly Ala Gly Cys Gly Thr Gly Gly Ala Gly 
    610                 615                 620                 


Gly Ala Gly Cys Thr Gly Cys Thr Gly Ala Thr Cys Gly Gly Cys Gly 
625                 630                 635                 640 


Gly Cys Gly Ala Gly Ala Thr Gly Ala Thr Cys Ala Ala Ala Gly Cys 
                645                 650                 655     


Cys Gly Gly Cys Ala Cys Cys Cys Thr Gly Ala Cys Ala Cys Thr Gly 
            660                 665                 670         


Gly Ala Gly Gly Ala Gly Gly Thr Gly Cys Gly Gly Cys Gly Cys Ala 
        675                 680                 685             


Ala Gly Thr Thr Cys Ala Ala Cys Ala Ala Cys Gly Gly Cys Gly Ala 
    690                 695                 700                 


Gly Ala Thr Cys Ala Ala Cys Thr Thr Cys Ala Gly Cys Gly Gly Cys 
705                 710                 715                 720 


Ala Cys Thr Cys Cys Ala Cys Ala Cys Gly Ala Ala Gly Thr Gly Gly 
                725                 730                 735     


Gly Ala Gly Thr Gly Thr Ala Cys Ala Cys Ala Cys Thr Thr Ala Gly 
            740                 745                 750         


Gly Cys Cys Cys Thr Thr Cys Cys Ala Gly Thr Gly Thr Cys Gly Ala 
        755                 760                 765             


Ala Thr Cys Thr Gly Cys Ala Thr Gly Cys Gly Thr Ala Ala Cys Thr 
    770                 775                 780                 


Thr Cys Ala Gly Thr Cys Gly Thr Ala Gly Thr Gly Ala Cys Cys Ala 
785                 790                 795                 800 


Cys Cys Thr Gly Ala Gly Cys Cys Gly Gly Cys Ala Cys Ala Thr Cys 
                805                 810                 815     


Cys Gly Cys Ala Cys Cys Cys Ala Cys Ala Cys Ala Gly Gly Cys Gly 
            820                 825                 830         


Ala Gly Ala Ala Gly Cys Cys Thr Thr Thr Thr Gly Cys Cys Thr Gly 
        835                 840                 845             


Thr Gly Ala Cys Ala Thr Thr Thr Gly Thr Gly Gly Gly Ala Gly Gly 
    850                 855                 860                 


Ala Ala Ala Thr Thr Thr Gly Cys Cys Gly Ala Cys Ala Gly Cys Ala 
865                 870                 875                 880 


Gly Cys Gly Ala Cys Cys Gly Cys Ala Ala Ala Ala Ala Gly Cys Ala 
                885                 890                 895     


Thr Ala Cys Cys Ala Ala Gly Ala Thr Ala Cys Ala Cys Ala Cys Gly 
            900                 905                 910         


Gly Gly Cys Gly Ala Gly Ala Ala Gly Cys Cys Cys Thr Thr Cys Cys 
        915                 920                 925             


Ala Gly Thr Gly Thr Cys Gly Ala Ala Thr Cys Thr Gly Cys Ala Thr 
    930                 935                 940                 


Gly Cys Gly Thr Ala Ala Cys Thr Thr Cys Ala Gly Thr Cys Gly Cys 
945                 950                 955                 960 


Thr Cys Cys Gly Ala Cys Ala Cys Cys Cys Thr Gly Thr Cys Cys Gly 
                965                 970                 975     


Ala Gly Cys Ala Cys Ala Thr Cys Cys Gly Cys Ala Cys Cys Cys Ala 
            980                 985                 990         


Cys Ala Cys Cys Gly Gly Cys Gly  Ala Gly Ala Ala Gly  Cys Cys Thr 
        995                 1000                 1005             


Thr Thr  Thr Gly Cys Cys Thr  Gly Thr Gly Ala Cys  Ala Thr Thr 
    1010                 1015                 1020             


Thr Gly  Thr Gly Gly Gly Ala  Gly Gly Ala Ala Ala  Thr Thr Thr 
    1025                 1030                 1035             


Gly Cys  Cys Cys Ala Gly Thr  Cys Cys Gly Gly Cys  Gly Ala Cys 
    1040                 1045                 1050             


Cys Thr  Gly Ala Cys Cys Cys  Gly Cys Cys Ala Thr  Ala Cys Cys 
    1055                 1060                 1065             


Ala Ala  Gly Ala Thr Ala Cys  Ala Cys Ala Cys Gly  Cys Ala Cys 
    1070                 1075                 1080             


Cys Cys  Gly Cys Gly Cys Gly  Cys Cys Cys Cys Gly  Ala Thr Cys 
    1085                 1090                 1095             


Cys Cys  Gly Ala Ala Gly Cys  Cys Cys Thr Thr Cys  Cys Ala Gly 
    1100                 1105                 1110             


Thr Gly  Thr Cys Gly Ala Ala  Thr Cys Thr Gly Cys  Ala Thr Gly 
    1115                 1120                 1125             


Cys Gly  Thr Ala Ala Cys Thr  Thr Cys Ala Gly Thr  Cys Ala Gly 
    1130                 1135                 1140             


Thr Cys  Cys Thr Cys Cys Gly  Ala Cys Cys Thr Gly  Thr Cys Cys 
    1145                 1150                 1155             


Cys Gly  Cys Cys Ala Cys Ala  Thr Cys Cys Gly Cys  Ala Cys Cys 
    1160                 1165                 1170             


Cys Ala  Cys Ala Cys Cys Gly  Gly Cys Gly Ala Gly  Ala Ala Gly 
    1175                 1180                 1185             


Cys Cys  Thr Thr Thr Thr Gly  Cys Cys Thr Gly Thr  Gly Ala Cys 
    1190                 1195                 1200             


Ala Thr  Thr Thr Gly Thr Gly  Gly Gly Ala Gly Gly  Ala Ala Ala 
    1205                 1210                 1215             


Thr Thr  Thr Gly Cys Cys Thr  Ala Cys Ala Ala Gly  Thr Gly Gly 
    1220                 1225                 1230             


Ala Cys  Cys Cys Thr Gly Cys  Gly Cys Ala Ala Cys  Cys Ala Thr 
    1235                 1240                 1245             


Ala Cys  Cys Ala Ala Gly Ala  Thr Ala Cys Ala Cys  Cys Thr Gly 
    1250                 1255                 1260             


Cys Gly  Gly Cys Ala Gly Ala  Ala Gly Gly Ala Cys  
    1265                 1270                 1275 


<210>  54
<211>  425
<212>  PRT
<213>  artificial sequence

<220>
<223>  ZFN CIITA 87278 protein

<400>  54

Met Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp 
1               5                   10                  15      


Tyr Lys Asp Asp Asp Asp Lys Met Ala Pro Lys Lys Lys Arg Lys Val 
            20                  25                  30          


Gly Ile His Gly Val Pro Ala Ala Met Gly Gln Leu Val Lys Ser Glu 
        35                  40                  45              


Leu Glu Glu Lys Lys Ser Glu Leu Arg His Lys Leu Lys Tyr Val Pro 
    50                  55                  60                  


His Glu Tyr Ile Glu Leu Ile Glu Ile Ala Arg Asn Ser Thr Gln Asp 
65                  70                  75                  80  


Arg Ile Leu Glu Met Lys Val Met Glu Phe Phe Met Lys Val Tyr Gly 
                85                  90                  95      


Tyr Arg Gly Lys His Leu Gly Gly Ser Arg Lys Pro Asp Gly Ala Ile 
            100                 105                 110         


Tyr Thr Val Gly Ser Pro Ile Asp Tyr Gly Val Ile Val Asp Thr Lys 
        115                 120                 125             


Ala Tyr Ser Gly Gly Tyr Asn Leu Pro Ile Gly Gln Ala Asp Glu Met 
    130                 135                 140                 


Glu Arg Tyr Val Glu Glu Asn Gln Thr Arg Asp Lys His Leu Asn Pro 
145                 150                 155                 160 


Asn Glu Trp Trp Lys Val Tyr Pro Ser Ser Val Thr Glu Phe Lys Phe 
                165                 170                 175     


Leu Phe Val Ser Gly His Phe Ser Gly Asn Tyr Lys Ala Gln Leu Thr 
            180                 185                 190         


Arg Leu Asn His Ile Thr Asn Cys Asn Gly Ala Val Leu Ser Val Glu 
        195                 200                 205             


Glu Leu Leu Ile Gly Gly Glu Met Ile Lys Ala Gly Thr Leu Thr Leu 
    210                 215                 220                 


Glu Glu Val Arg Arg Lys Phe Asn Asn Gly Glu Ile Asn Phe Ser Gly 
225                 230                 235                 240 


Thr Pro His Glu Val Gly Val Tyr Thr Leu Arg Pro Phe Gln Cys Arg 
                245                 250                 255     


Ile Cys Met Arg Asn Phe Ser Arg Ser Asp His Leu Ser Arg His Ile 
            260                 265                 270         


Arg Thr His Thr Gly Glu Lys Pro Phe Ala Cys Asp Ile Cys Gly Arg 
        275                 280                 285             


Lys Phe Ala Asp Ser Ser Asp Arg Lys Lys His Thr Lys Ile His Thr 
    290                 295                 300                 


Gly Glu Lys Pro Phe Gln Cys Arg Ile Cys Met Arg Asn Phe Ser Arg 
305                 310                 315                 320 


Ser Asp Thr Leu Ser Glu His Ile Arg Thr His Thr Gly Glu Lys Pro 
                325                 330                 335     


Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Gln Ser Gly Asp Leu 
            340                 345                 350         


Thr Arg His Thr Lys Ile His Thr His Pro Arg Ala Pro Ile Pro Lys 
        355                 360                 365             


Pro Phe Gln Cys Arg Ile Cys Met Arg Asn Phe Ser Gln Ser Ser Asp 
    370                 375                 380                 


Leu Ser Arg His Ile Arg Thr His Thr Gly Glu Lys Pro Phe Ala Cys 
385                 390                 395                 400 


Asp Ile Cys Gly Arg Lys Phe Ala Tyr Lys Trp Thr Leu Arg Asn His 
                405                 410                 415     


Thr Lys Ile His Leu Arg Gln Lys Asp 
            420                 425 


<210>  55
<211>  1053
<212>  DNA
<213>  artificial sequence

<220>
<223>  ZFN CIITA 87232 DNA

<400>  55
cagctggtga agagcgagct ggaggagaag aagtccgagc tgcggcacaa gctgaagtac       60

gtgccccacg agtacatcga gctgatcgag atcgccagga acagcaccca ggaccgcatc      120

ctggagatga aggtgatgga gttcttcatg aaggtgtacg gctacagggg aaagcacctg      180

ggcggaagca gaaagcctga cggcgccatc tatacagtgg gcagccccat cgattacggc      240

gtgatcgtgg acacaaaggc ctacagcggc ggctacaatc tgcctaccgg ccaggccgac      300

gagatgcaga gatacgtgaa ggagaaccag acccggaata agcacatcaa ccccaacgag      360

tggtggaagg tgtaccctag cagcgtgacc gagttcaagt tcctgttcgt gagcggccac      420

ttcaagggca actacaaggc ccagctgacc aggctgaacc gcaaaaccaa ctgcaatggc      480

gccgtgctga gcgtggagga gctgctgatc ggcggcgaga tgatcaaagc cggcaccctg      540

acactggagg aggtgcggcg caagttcaac aacggcgaga tcaacttcag cggcactcca      600

cacgaagtgg gagtgtacac acttaggccc ttccagtgtc gaatctgcat gcgtaacttc      660

agttccaacc agaacctgac cacccacatc cgcacccaca ccggcgagaa gccttttgcc      720

tgtgacattt gtgggaggaa atttgccgac cgctcccacc tggcccgcca taccaagata      780

cacacgggcg agaagccctt ccagtgtcga atctgcatgc agaagtttgc ccagtccggc      840

gacctgaccc gccataccaa gatacacacg ggcgagaagc ccttccagtg tcgaatctgc      900

atgcagaact tcagttggaa gcacgacctg accaaccaca tccgcaccca caccggcgag      960

aagccttttg cctgtgacat ttgtgggagg aaatttgcca cctccggcaa cctgacccgc     1020

cataccaaga tacacctgcg gcagaaggac tga                                  1053


<210>  56
<211>  350
<212>  PRT
<213>  artificial sequence

<220>
<223>  ZFN CIITA 87232 protein

<400>  56

Gln Leu Val Lys Ser Glu Leu Glu Glu Lys Lys Ser Glu Leu Arg His 
1               5                   10                  15      


Lys Leu Lys Tyr Val Pro His Glu Tyr Ile Glu Leu Ile Glu Ile Ala 
            20                  25                  30          


Arg Asn Ser Thr Gln Asp Arg Ile Leu Glu Met Lys Val Met Glu Phe 
        35                  40                  45              


Phe Met Lys Val Tyr Gly Tyr Arg Gly Lys His Leu Gly Gly Ser Arg 
    50                  55                  60                  


Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly Ser Pro Ile Asp Tyr Gly 
65                  70                  75                  80  


Val Ile Val Asp Thr Lys Ala Tyr Ser Gly Gly Tyr Asn Leu Pro Thr 
                85                  90                  95      


Gly Gln Ala Asp Glu Met Gln Arg Tyr Val Lys Glu Asn Gln Thr Arg 
            100                 105                 110         


Asn Lys His Ile Asn Pro Asn Glu Trp Trp Lys Val Tyr Pro Ser Ser 
        115                 120                 125             


Val Thr Glu Phe Lys Phe Leu Phe Val Ser Gly His Phe Lys Gly Asn 
    130                 135                 140                 


Tyr Lys Ala Gln Leu Thr Arg Leu Asn Arg Lys Thr Asn Cys Asn Gly 
145                 150                 155                 160 


Ala Val Leu Ser Val Glu Glu Leu Leu Ile Gly Gly Glu Met Ile Lys 
                165                 170                 175     


Ala Gly Thr Leu Thr Leu Glu Glu Val Arg Arg Lys Phe Asn Asn Gly 
            180                 185                 190         


Glu Ile Asn Phe Ser Gly Thr Pro His Glu Val Gly Val Tyr Thr Leu 
        195                 200                 205             


Arg Pro Phe Gln Cys Arg Ile Cys Met Arg Asn Phe Ser Ser Asn Gln 
    210                 215                 220                 


Asn Leu Thr Thr His Ile Arg Thr His Thr Gly Glu Lys Pro Phe Ala 
225                 230                 235                 240 


Cys Asp Ile Cys Gly Arg Lys Phe Ala Asp Arg Ser His Leu Ala Arg 
                245                 250                 255     


His Thr Lys Ile His Thr Gly Glu Lys Pro Phe Gln Cys Arg Ile Cys 
            260                 265                 270         


Met Gln Lys Phe Ala Gln Ser Gly Asp Leu Thr Arg His Thr Lys Ile 
        275                 280                 285             


His Thr Gly Glu Lys Pro Phe Gln Cys Arg Ile Cys Met Gln Asn Phe 
    290                 295                 300                 


Ser Trp Lys His Asp Leu Thr Asn His Ile Arg Thr His Thr Gly Glu 
305                 310                 315                 320 


Lys Pro Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Thr Ser Gly 
                325                 330                 335     


Asn Leu Thr Arg His Thr Lys Ile His Leu Arg Gln Lys Asp 
            340                 345                 350 


<210>  57
<211>  5670
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  57
gctgcttcgc gatgtacggg ccagatatac gcgcatgttc tttcctgcgt tatcccctga       60

ttctgtggat aaccgtatta ccgcctttga gtgagctgat accgctcgcc gcagccgaac      120

gaccgagcgc agcgagtcag tgagcgagga agcggaagag cgcccaatac gcaaaccgcc      180

tctccccgcg cgttggccga ttcattaatg cagctggcac gacaggtttc ccgactggaa      240

agcgggcagt gagcgcaacg caattaatgt gagttagctc actcattagg caccccaggc      300

tttacacttt atgcttccgg ctcgtatgtt gtgtggaatt gtgagcggat aacaatttca      360

cacaggaaac agctatgacc atgattacgc caagctctaa tacgactcac tatagggaga      420

caagcttgaa tacaagcttg cttgttcttt ttgcagaagc tcagaataaa cgctcaactt      480

tggcagatcg aattcgccat ggactacaaa gaccatgacg gtgattataa agatcatgac      540

atcgattaca aggatgacga tgacaagatg gcccccaaga agaagaggaa ggtcggcatc      600

cacggggtac ccgccgctat gggacagctg gtgaagagcg agctggagga gaagaagtcc      660

gagctgcggc acaagctgaa gtacgtgccc cacgagtaca tcgagctgat cgagatcgcc      720

aggaacagca cccaggaccg catcctggag atgaaggtga tggagttctt catgaaggtg      780

tacggctaca ggggaaagca cctgggcgga agcagaaagc ctgacggcgc catctataca      840

gtgggcagcc ccatcgatta cggcgtgatc gtggacacaa aggcctacag cggcggctac      900

aatctgccta tcggccaggc cgacgagatg gagagatacg tggaggagaa ccagacccgg      960

gataagcacc tcaaccccaa cgagtggtgg aaggtgtacc ctagcagcgt gaccgagttc     1020

aagttcctgt tcgtgagcgg ccacttcagc ggcaactaca aggcccagct gaccaggctg     1080

aaccacatca ccaactgcaa tggcgccgtg ctgagcgtgg aggagctgct gatcggcggc     1140

gagatgatca aagccggcac cctgacactg gaggaggtgc ggcgcaagtt caacaacggc     1200

gagatcaact tcagcggcac tccacacgaa gtgggagtgt acacacttag gcccttccag     1260

tgtcgaatct gcatgcgtaa cttcagtcgt agtgaccacc tgagccggca catccgcacc     1320

cacacaggcg agaagccttt tgcctgtgac atttgtggga ggaaatttgc cgacagcagc     1380

gaccgcaaaa agcataccaa gatacacacg ggcgagaagc ccttccagtg tcgaatctgc     1440

atgcgtaact tcagtcgctc cgacaccctg tccgagcaca tccgcaccca caccggcgag     1500

aagccttttg cctgtgacat ttgtgggagg aaatttgccc agtccggcga cctgacccgc     1560

cataccaaga tacacacgca cccgcgcgcc ccgatcccga agcccttcca gtgtcgaatc     1620

tgcatgcgta acttcagtca gtcctccgac ctgtcccgcc acatccgcac ccacaccggc     1680

gagaagcctt ttgcctgtga catttgtggg aggaaatttg cctacaagtg gaccctgcgc     1740

aaccatacca agatacacct gcggcagaag gacagatctg gcggcggaga gggcagagga     1800

agtcttctaa cctgcggtga cgtggaggag aatcccggcc ctaggaccat ggactacaaa     1860

gaccatgacg gtgattataa agatcatgac atcgattaca aggatgacga tgacaagatg     1920

gcccccaaga agaagaggaa ggtcggcatt catggggtac ccgccgctat gggacagctg     1980

gtgaagagcg agctggagga gaagaagtcc gagctgcggc acaagctgaa gtacgtgccc     2040

cacgagtaca tcgagctgat cgagatcgcc aggaacagca cccaggaccg catcctggag     2100

atgaaggtga tggagttctt catgaaggtg tacggctaca ggggaaagca cctgggcgga     2160

agcagaaagc ctgacggcgc catctataca gtgggcagcc ccatcgatta cggcgtgatc     2220

gtggacacaa aggcctacag cggcggctac aatctgccta ccggccaggc cgacgagatg     2280

cagagatacg tgaaggagaa ccagacccgg aataagcaca tcaaccccaa cgagtggtgg     2340

aaggtgtacc ctagcagcgt gaccgagttc aagttcctgt tcgtgagcgg ccacttcaag     2400

ggcaactaca aggcccagct gaccaggctg aaccgcaaaa ccaactgcaa tggcgccgtg     2460

ctgagcgtgg aggagctgct gatcggcggc gagatgatca aagccggcac cctgacactg     2520

gaggaggtgc ggcgcaagtt caacaacggc gagatcaact tcagcggcac tccacacgaa     2580

gtgggagtgt acacacttag gcccttccag tgtcgaatct gcatgcgtaa cttcagttcc     2640

aaccagaacc tgaccaccca catccgcacc cacaccggcg agaagccttt tgcctgtgac     2700

atttgtggga ggaaatttgc cgaccgctcc cacctggccc gccataccaa gatacacacg     2760

ggcgagaagc ccttccagtg tcgaatctgc atgcagaagt ttgcccagtc cggcgacctg     2820

acccgccata ccaagataca cacgggcgag aagcccttcc agtgtcgaat ctgcatgcag     2880

aacttcagtt ggaagcacga cctgaccaac cacatccgca cccacaccgg cgagaagcct     2940

tttgcctgtg acatttgtgg gaggaaattt gccacctccg gcaacctgac ccgccatacc     3000

aagatacacc tgcggcagaa ggactgataa ctcgagtcta gaagctcgct ttcttgctgt     3060

ccaatttcta ttaaaggttc ctttgttccc taagtccaac tactaaactg ggggatatta     3120

tgaagggcct tgagcatctg gattctgcct aataaaaaac atttattttc attgctgcgc     3180

tagaagctcg ctttcttgct gtccaatttc tattaaaggt tcctttgttc cctaagtcca     3240

actactaaac tgggggatat tatgaagggc cttgagcatc tggattctgc ctaataaaaa     3300

acatttattt tcattgctgc gggacattct taattaaaaa aaaaaaaaaa aaaaaaaaaa     3360

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaactagt ggcgcctgat gcggtatttt     3420

ctccttacgc atctgtgcgg tatttcacac cgcataatcc agcacagtgg cggcccgttt     3480

aaacccgctg atcagcctcg actgtgcctt ctagttgcca gccatctgtt gtttgcccct     3540

cccccgtgcc ttccttgacc ctggaaggtg ccactcccac tgtcctttcc taataaaatg     3600

aggaaattgc atcgcattgt ctgagtaggt gtcattctat tctggggggt ggggtggggc     3660

aggacagcaa gggggaggat tgggaagaca atagcaggca tgctggggat gcggtgggct     3720

ctatggcttc tactgggcgg ttttatggac agcaagcgaa ccggaattgc cagctggggc     3780

gccctctggt aaggttggga agccctgcaa agtaaactgg atggctttct tgccgccaag     3840

gatctgatgg cgcaggggat caagctctga tcaagagaca ggatgaggat cgtttcgcat     3900

gattgaacaa gatggattga cgcaggttct ccggccgctt gggtggagag gctattcggc     3960

tatgactggg cacaacagac aatcggctgc tctgatgccg ccgtgttccg gctgtcagcg     4020

caggggcgcc cggttctttt tgtcaagacc gacctgtccg gtgccctgaa tgaactgcaa     4080

gacgaggcag cgcggctatc gtggctggcc acgacgggcg ttccttgcgc agctgtgctc     4140

gacgttgtca ctgaagcggg aagggactgg ctgctattgg gcgaagtgcc ggggcaggat     4200

ctcctgtcat ctcaccttgc tcctgccgag aaagtatcca tcatggctga tgcaatgcgg     4260

cggctgcata cgcttgatcc ggctacctgc ccattcgacc accaagcgaa acatcgcatc     4320

gagcgagcac gtactcggat ggaagccggt cttgtcgatc aggatgatct ggacgaagag     4380

catcaggggc tcgcgccagc cgaactgttc gccaggctca aggcgagcat gcccgacggc     4440

gaggatctcg tcgtgaccca tggcgatgcc tgcttgccga atatcatggt ggaaaatggc     4500

cgcttttctg gattcatcga ctgtggccgg ctgggtgtgg cggaccgcta tcaggacata     4560

gcgttggcta cccgtgatat tgctgaagag cttggcggcg aatgggctga ccgcttcctc     4620

gtgctttacg gtatcgccgc tcccgattcg cagcgcatcg ccttctatcg ccttcttgac     4680

gagttcttct gaattattaa cgcttacaat ttcctgatgc ggtattttct ccttacgcat     4740

ctgtgcggta tttcacaccg catcaggtgg cacttttcgg ggaaatgtgc gcggaacccc     4800

tatttgttta tttttctaaa tacattcaaa tatgtatccg ctcatgagac aataaccctg     4860

ataaatgctt caataatagc acgtgctaaa acttcatttt taatttaaaa ggatctaggt     4920

gaagatcctt tttgataatc tcatgaccaa aatcccttaa cgtgagtttt cgttccactg     4980

agcgtcagac cccgtagaaa agatcaaagg atcttcttga gatccttttt ttctgcgcgt     5040

aatctgctgc ttgcaaacaa aaaaaccacc gctaccagcg gtggtttgtt tgccggatca     5100

agagctacca actctttttc cgaaggtaac tggcttcagc agagcgcaga taccaaatac     5160

tgttcttcta gtgtagccgt agttaggcca ccacttcaag aactctgtag caccgcctac     5220

atacctcgct ctgctaatcc tgttaccagt ggctgctgcc agtggcgata agtcgtgtct     5280

taccgggttg gactcaagac gatagttacc ggataaggcg cagcggtcgg gctgaacggg     5340

gggttcgtgc acacagccca gcttggagcg aacgacctac accgaactga gatacctaca     5400

gcgtgagcta tgagaaagcg ccacgcttcc cgaagggaga aaggcggaca ggtatccggt     5460

aagcggcagg gtcggaacag gagagcgcac gagggagctt ccagggggaa acgcctggta     5520

tctttatagt cctgtcgggt ttcgccacct ctgacttgag cgtcgatttt tgtgatgctc     5580

gtcagggggg cggagcctat ggaaaaacgc cagcaacgcg gcctttttac ggttcctggc     5640

cttttgctgg ccttttgctc acatgttctt                                      5670


