                         SEQUENCE LISTING

<110>  Centre for Eye Research Australia Ltd
 
<120>  Macular telangiectasia type 2 treatment

<130>  53183729AZD

<150>  AU 2021901673
<151>  2021-06-04

<160>  27    

<170>  PatentIn version 3.5

<210>  1
<211>  1602
<212>  DNA
<213>  Homo sapiens

<400>  1
atggcttttg caaatctgcg gaaagtgctc atcagtgaca gcctggaccc ttgctgccgg       60

aagatcttgc aagatggagg gctgcaggtg gtggaaaagc agaaccttag caaagaggag      120

ctgatagcgg agctgcagga ctgtgaaggc cttattgttc gctctgccac caaggtgacc      180

gctgatgtca tcaacgcagc tgagaaactc caggtggtgg gcagggctgg cacaggtgtg      240

gacaatgtgg atctggaggc cgcaacaagg aagggcatct tggttatgaa cacccccaat      300

gggaacagcc tcagtgccgc agaactcact tgtggaatga tcatgtgcct ggccaggcag      360

attccccagg cgacggcttc gatgaaggac ggcaaatggg agcggaagaa gttcatggga      420

acagagctga atggaaagac cctgggaatt cttggcctgg gcaggattgg gagagaggta      480

gctacccgga tgcagtcctt tgggatgaag actatagggt atgaccccat catttcccca      540

gaggtctcgg cctcctttgg tgttcagcag ctgcccctgg aggagatctg gcctctctgt      600

gatttcatca ctgtgcacac tcctctcctg ccctccacga caggcttgct gaatgacaac      660

acctttgccc agtgcaagaa gggggtgcgt gtggtgaact gtgcccgtgg agggatcgtg      720

gacgaaggcg ccctgctccg ggccctgcag tctggccagt gtgccggggc tgcactggac      780

gtgtttacgg aagagccgcc acgggaccgg gccttggtgg accatgagaa tgtcatcagc      840

tgtccccacc tgggtgccag caccaaggag gctcagagcc gctgtgggga ggaaattgct      900

gttcagttcg tggacatggt gaaggggaaa tctctcacgg gggttgtgaa tgcccaggcc      960

cttaccagtg ccttctctcc acacaccaag ccttggattg gtctggcaga agctctgggg     1020

acactgatgc gagcctgggc tgggtccccc aaagggacca tccaggtgat aacacaggga     1080

acatccctga agaatgctgg gaactgccta agccccgcag tcattgtcgg cctcctgaaa     1140

gaggcttcca agcaggcgga tgtgaacttg gtgaacgcta agctgctggt gaaagaggct     1200

ggcctcaatg tcaccacctc ccacagccct gctgcaccag gggagcaagg cttcggggaa     1260

tgcctcctgg ccgtggccct ggcaggcgcc ccttaccagg ctgtgggctt ggtccaaggc     1320

actacgcctg tactgcaggg gctcaatgga gctgtcttca ggccagaagt gcctctccgc     1380

agggacctgc ccctgctcct attccggact cagacctctg accctgcaat gctgcctacc     1440

atgattggcc tcctggcaga ggcaggcgtg cggctgctgt cctaccagac ttcactggtg     1500

tcagatgggg agacctggca cgtcatgggc atctcctcct tgctgcccag cctggaagcg     1560

tggaagcagc atgtgactga agccttccag ttccacttct aa                        1602


<210>  2
<211>  1602
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon-optimized PHGDH

<400>  2
atggcattcg ctaatctgag gaaggtgctg atctctgact ctctggaccc ctgttgtcgc       60

aaaattctgc aggatggcgg gctgcaggtg gtggagaagc agaacctgag caaggaggag      120

ctgatcgccg agctgcagga ctgcgagggc ctgatcgtgc ggtccgccac caaggtgaca      180

gccgatgtga tcaatgccgc cgagaagctg caggtggtgg gaagggcagg caccggcgtg      240

gacaacgtgg atctggaggc cgccaccaga aagggcatcc tggtcatgaa tacaccaaac      300

ggcaattctc tgagcgccgc agagctgacc tgcggaatga tcatgtgcct ggcaaggcag      360

atcccacagg caacagcctc tatgaaggac ggcaagtggg agagaaagaa gttcatgggc      420

accgagctga acggcaagac actgggcatc ctgggcctgg gaaggatcgg aagagaggtg      480

gcaaccagaa tgcagtcctt tggcatgaag acaatcggct acgatccaat catctctccc      540

gaggtgtccg cctctttcgg cgtgcagcag ctgccactgg aggagatttg gcccctgtgc      600

gactttatca ccgtgcacac accactgctg ccctccacca caggcctgct gaacgataat      660

accttcgccc agtgcaagaa gggcgtgagg gtggtgaatt gtgccagagg cggcatcgtg      720

gacgagggcg ccctgctgag ggccctgcag tccggacagt gtgcaggagc cgccctggac      780

gtgttcaccg aggagccacc tagggaccgc gccctggtgg atcacgagaa cgtgatctct      840

tgccctcacc tgggagcaag cacaaaggag gcacagtccc gctgtggaga ggagatcgcc      900

gtgcagttcg tggacatggt gaagggcaag agcctgaccg gagtggtgaa tgcacaggcc      960

ctgacctctg cctttagccc tcacacaaag ccctggatcg gcctggcaga ggccctgggc     1020

accctgatga gggcctgggc aggcagcccc aagggcacaa tccaggtcat cacccagggc     1080

acatctctga agaacgccgg caattgcctg agccctgccg tgatcgtggg cctgctgaag     1140

gaggcctcca agcaggccga tgtgaacctg gtgaatgcca agctgctggt gaaggaggcc     1200

ggcctgaacg tgaccacaag ccactcccct gcagcaccag gagagcaggg attcggagag     1260

tgtctgctgg cagtggccct ggcaggagca ccttaccagg cagtgggcct ggtgcagggc     1320

accacaccag tgctgcaggg cctgaatggc gccgtgttca ggccagaggt gcctctgagg     1380

cgggacctgc cactgctgct gtttcgcacc cagacatctg atcccgccat gctgcctacc     1440

atgatcggcc tgctggcaga ggcaggcgtg agactgctga gctatcagac ctccctggtg     1500

tctgacggcg agacatggca cgtgatgggc atcagctccc tgctgccatc tctggaggct     1560

tggaagcagc atgtcaccga ggcttttcag tttcatttct aa                        1602


<210>  3
<211>  533
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ala Phe Ala Asn Leu Arg Lys Val Leu Ile Ser Asp Ser Leu Asp 
1               5                   10                  15      


Pro Cys Cys Arg Lys Ile Leu Gln Asp Gly Gly Leu Gln Val Val Glu 
            20                  25                  30          


Lys Gln Asn Leu Ser Lys Glu Glu Leu Ile Ala Glu Leu Gln Asp Cys 
        35                  40                  45              


Glu Gly Leu Ile Val Arg Ser Ala Thr Lys Val Thr Ala Asp Val Ile 
    50                  55                  60                  


Asn Ala Ala Glu Lys Leu Gln Val Val Gly Arg Ala Gly Thr Gly Val 
65                  70                  75                  80  


Asp Asn Val Asp Leu Glu Ala Ala Thr Arg Lys Gly Ile Leu Val Met 
                85                  90                  95      


Asn Thr Pro Asn Gly Asn Ser Leu Ser Ala Ala Glu Leu Thr Cys Gly 
            100                 105                 110         


Met Ile Met Cys Leu Ala Arg Gln Ile Pro Gln Ala Thr Ala Ser Met 
        115                 120                 125             


Lys Asp Gly Lys Trp Glu Arg Lys Lys Phe Met Gly Thr Glu Leu Asn 
    130                 135                 140                 


Gly Lys Thr Leu Gly Ile Leu Gly Leu Gly Arg Ile Gly Arg Glu Val 
145                 150                 155                 160 


Ala Thr Arg Met Gln Ser Phe Gly Met Lys Thr Ile Gly Tyr Asp Pro 
                165                 170                 175     


Ile Ile Ser Pro Glu Val Ser Ala Ser Phe Gly Val Gln Gln Leu Pro 
            180                 185                 190         


Leu Glu Glu Ile Trp Pro Leu Cys Asp Phe Ile Thr Val His Thr Pro 
        195                 200                 205             


Leu Leu Pro Ser Thr Thr Gly Leu Leu Asn Asp Asn Thr Phe Ala Gln 
    210                 215                 220                 


Cys Lys Lys Gly Val Arg Val Val Asn Cys Ala Arg Gly Gly Ile Val 
225                 230                 235                 240 


Asp Glu Gly Ala Leu Leu Arg Ala Leu Gln Ser Gly Gln Cys Ala Gly 
                245                 250                 255     


Ala Ala Leu Asp Val Phe Thr Glu Glu Pro Pro Arg Asp Arg Ala Leu 
            260                 265                 270         


Val Asp His Glu Asn Val Ile Ser Cys Pro His Leu Gly Ala Ser Thr 
        275                 280                 285             


Lys Glu Ala Gln Ser Arg Cys Gly Glu Glu Ile Ala Val Gln Phe Val 
    290                 295                 300                 


Asp Met Val Lys Gly Lys Ser Leu Thr Gly Val Val Asn Ala Gln Ala 
305                 310                 315                 320 


Leu Thr Ser Ala Phe Ser Pro His Thr Lys Pro Trp Ile Gly Leu Ala 
                325                 330                 335     


Glu Ala Leu Gly Thr Leu Met Arg Ala Trp Ala Gly Ser Pro Lys Gly 
            340                 345                 350         


Thr Ile Gln Val Ile Thr Gln Gly Thr Ser Leu Lys Asn Ala Gly Asn 
        355                 360                 365             


Cys Leu Ser Pro Ala Val Ile Val Gly Leu Leu Lys Glu Ala Ser Lys 
    370                 375                 380                 


Gln Ala Asp Val Asn Leu Val Asn Ala Lys Leu Leu Val Lys Glu Ala 
385                 390                 395                 400 


Gly Leu Asn Val Thr Thr Ser His Ser Pro Ala Ala Pro Gly Glu Gln 
                405                 410                 415     


Gly Phe Gly Glu Cys Leu Leu Ala Val Ala Leu Ala Gly Ala Pro Tyr 
            420                 425                 430         


Gln Ala Val Gly Leu Val Gln Gly Thr Thr Pro Val Leu Gln Gly Leu 
        435                 440                 445             


Asn Gly Ala Val Phe Arg Pro Glu Val Pro Leu Arg Arg Asp Leu Pro 
    450                 455                 460                 


Leu Leu Leu Phe Arg Thr Gln Thr Ser Asp Pro Ala Met Leu Pro Thr 
465                 470                 475                 480 


Met Ile Gly Leu Leu Ala Glu Ala Gly Val Arg Leu Leu Ser Tyr Gln 
                485                 490                 495     


Thr Ser Leu Val Ser Asp Gly Glu Thr Trp His Val Met Gly Ile Ser 
            500                 505                 510         


Ser Leu Leu Pro Ser Leu Glu Ala Trp Lys Gln His Val Thr Glu Ala 
        515                 520                 525             


Phe Gln Phe His Phe 
    530             


<210>  4
<211>  245
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CMV early enhancer element

<400>  4
ccattgacgt caataatgac gtatgttccc atagtaacgc caatagggac tttccattga       60

cgtcaatggg tggagtattt acggtaaact gcccacttgg cagtacatca agtgtatcat      120

atgccaagta cgccccctat tgacgtcaat gacggtaaat ggcccgcctg gcattatgcc      180

cagtacatga ccttatggga ctttcctact tggcagtaca tctacgtatt agtcatcgct      240

attac                                                                  245


<210>  5
<211>  283
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Promoter

<400>  5
catggtcgag gtgagcccca cgttctgctt cactctcccc atctcccccc cctccccacc       60

cccaattttg tatttattta ttttttaatt attttgtgca gcgatggggg cggggggggg      120

gggggggcgc gcgccaggcg gggcggggcg gggcgagggg cggggcgggg cgaggcggag      180

aggtgcggcg gcagccaatc agagcggcgc gctccgaaag tttcctttta tggcgaggcg      240

gcggcggcgg cggccctata aaaagcgaag cgcgcggcgg gcg                        283


<210>  6
<211>  408
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  First intron of chicken-beta actin gene (CBA)

<400>  6
ggagtcgctg cgcgctgcct tcgccccgtg ccccgctccg ccgccgcctc gcgccgcccg       60

ccccggctct gactgaccgc gttactccca caggtgagcg ggcgggacgg cccttctcct      120

ccgggctgta attagcgctt ggtttaatga cggcttgttt cttttctgtg gctgcgtgaa      180

agccttgagg ggctccggga gggccctttg tgcgggggga gcggctcggg gctgtccgcg      240

gggggacggc tgccttcggg ggggacgggg cagggcgggg ttcggcttct ggcgtgtgac      300

cggcggctct agagcctctg ctaaccatgt tcatgccttc ttctttttcc tacagctcct      360

gggcaacgtg ctggttattg tgctgtctca tcattttggc aaagaatt                   408


<210>  7
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Kozak sequence

<400>  7
ggcaccatgg                                                              10


<210>  8
<211>  593
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  WPRE sequence

<400>  8
atcgataatc aacctctgga ttacaaaatt tgtgaaagat tgactggtat tcttaactat       60

gttgctcctt ttacgctatg tggatacgct gctttaatgc ctttgtatca tgctattgct      120

tcccgtatgg ctttcatttt ctcctccttg tataaatcct ggttgctgtc tctttatgag      180

gagttgtggc ccgttgtcag gcaacgtggc gtggtgtgca ctgtgtttgc tgacgcaacc      240

cccactggtt ggggcattgc caccacctgt cagctccttt ccgggacttt cgctttcccc      300

ctccctattg ccacggcgga actcatcgcc gcctgccttg cccgctgctg gacaggggct      360

cggctgttgg gcactgacaa ttccgtggtg ttgtcgggga aatcatcgtc ctttccttgg      420

ctgctcgcct gtgttgccac ctggattctg cgcgggacgt ccttctgcta cgtcccttcg      480

gccctcaatc cagcggacct tccttcccgc ggcctgctgc cggctctgcg gcctcttccg      540

cgtcttcgcc ttcgccctca gacgagtcgg atctcccttt gggccgcctc ccc             593


<210>  9
<211>  269
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  bovine growth hormone (bGH) polyA tail sequence

<400>  9
cgctgatcag cctcgactgt gccttctagt tgccagccat ctgttgtttg cccctccccc       60

gtgccttcct tgaccctgga aggtgccact cccactgtcc tttcctaata aaatgaggaa      120

attgcatcgc attgtctgag taggtgtcat tctattctgg ggggtggggt ggggcaggac      180

agcaaggggg aggattggga agacaatagc aggcatgctg gggatgcggt gggctctatg      240

gcttctgagg cggaaagaac cagctgggg                                        269


<210>  10
<211>  141
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Left ITR

<400>  10
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc t                                                141


<210>  11
<211>  141
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Right ITR

<400>  11
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg       60

ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc      120

gagcgcgcag ctgcctgcag g                                                141


<210>  12
<211>  89
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  First stuffer sequence

<400>  12
gcggccaatt cagtcgataa ctataacggt cctaaggtag cgatttaaat cccgccatgc       60

tacttatcta cgtagccatg ctctaggta                                         89


<210>  13
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Second stuffer sequence

<400>  13
tctagcggcc gcgaattcga tatcaagctt                                        30


<210>  14
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Third stuffer sequence

<400>  14
ggcggccgcg caccgtcgac t                                                 21


<210>  15
<211>  79
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fourth stuffer sequence

<400>  15
ctcgactaga gcatggctac gtagataagt agcatggcgg gatttaaatt agggataaca       60

gggtaatggc gcgggccgc                                                    79


<210>  16
<211>  3288
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fifth stuffer sequence

<400>  16
ggcgcctgat gcggtatttt ctccttacgc atctgtgcgg tatttcacac cgcatacgtc       60

aaagcaacca tagtacgcgc cctgtagcgg cgcattaagc gcggcgggtg tggtggttac      120

gcgcagcgtg accgctacac ttgccagcgc cctagcgccc gctcctttcg ctttcttccc      180

ttcctttctc gccacgttcg ccggctttcc ccgtcaagct ctaaatcggg ggctcccttt      240

agggttccga tttagtgctt tacggcacct cgaccccaaa aaacttgatt tgggtgatgg      300

ttcacgtagt gcaattgtat ctaagccgtg taatgagaac atccacacct tagtgaatcg      360

atgcgccgct tcggaatacc gttttggcta cctgttacta agcccatcgc gattttcagg      420

tatcgtgcac gtagggttgc accgcacgca tgtcgaactg gtggcgaagt acgattccac      480

gaccggtgta cgattcaact acgcggacgt gacgagcttc ttatatatgc ttcgcccgcc      540

ggaccggcct cgtgatgggg tagctgcgca tgagcttatg acaaataacg agtgtgtact      600

tgtttaatca tctcacagtg aaagtcggga gaataggagc cgctacacac attttaccgc      660

aactacacct aactgagata ctaccataga tgactaccca tccctctagg ccttagataa      720

ccggatacag tgactttgat aggtttgtgg ggtacagcta tgacttgcat agctgcgtat      780

ggaggaagga acttttgcgt gttagtatgt tgacccgtgt attacgcatg cgggtagatc      840

atgtgggtag agacatccag gtcaagttct cgaccttctc gtgggaggtg atccagttca      900

ctataggacc attccattcg agcatggcac taagtacgcc gtccccattc tggtaatcat      960

catccctatc agggtttgga gtgagtggtg acggttattc cccaggaatg gacttcttat     1020

tcacagtcgg tcacattggg ctactccttg ggtcttccgc ttggcccggt ctgttgggcc     1080

gccattgcgt gagtttcggc cctgtgctgc gctgtgtcgg cgattctcat tggggcctca     1140

catctggaaa ccccgaccta ttttgacggc accattggcg gaagttgctg ggcttgtgca     1200

ccgtgaagtc ctccgcgggc ctccccccta caaaagacga taagctccgg caagcagcat     1260

tgatcaacgc aaggatcggc gatattaaca gagatacggc tgattactct tgttggtgtg     1320

gtatcgctaa actgcgccgc ggagccttat ggcaaagtcg tccgcgaacc attccggtag     1380

cgcttaaggt ccatagcaca ttcatcgcat cccggcgtgc gttcaatttg acgacccctt     1440

ggcgcaaagg tgctggccac gtgctaaatt aaagcggctg cactgctgta aggtccgtta     1500

cggagagggc ggcctgggga gagcactagc ccatcgacct gtacaggaac actctatatt     1560

gttctcggac ggacagatta ctagagtgcc gctttcagcc cccctgtcgt cgccgacgtc     1620

tgtaatatgg cgttgttgtg attccactct attgaggcat taactgatgc gtaaggagat     1680

ctggaatgaa ctggcctatg tcactgaaac tgtgcaaaca cccaatgtcg ttagtgtagg     1740

ttctgaccga tacctgcttc gttgagaact cacaatttta caactgggga cataatccct     1800

acgcccatca tctactcgcg tccctgtggc tccagttcat gtaatgggag agtatcctcc     1860

acaagatcta gtgctatggt ggtatagtaa gctcgtactg tggtagacgc gacacgggta     1920

ggaccatcag taataaggat agtgcgaaag ctcacagacc actgcctata gggggtgctt     1980

acttttacaa aaagcgactg tcagtataac cccacgagga ttcgaaaagg tgaaccgacc     2040

cagacgatcc ggaggcacgg gcctcaaagc cgcgacacga cggctgtcgg ccggtaacag     2100

taaccccgga gtgaactcct atggggctgg atagaacagc cctggtgggc cccatcagca     2160

acccgaatac gtggcttttc gggaggcggc cggaggggcg atgtcttcca ctattcgagg     2220

ccgttcgtta atacttgttg cgttcctagc cgctatattt gtctctttgc cgactaatgt     2280

ggacaagcac accatagcca tttatcggag cgcctcggaa tacggtatga gcaggcgcct     2340

cgtgagacca ttgcgaatac caggtgtcct gtggcgcctg atgcggtatt ttctccttac     2400

gcatctgtgc ggtatttcac accgcatacg tcaaagcaac catagtacgc gccctgtagc     2460

ggcgcattaa gcgcggcggg tgtggtggtt acgcgcagcg tgaccgctac acttgccagc     2520

gccctagcgc ccgctccttt cgctttcttc ccttcctttc tcgccacgtt cgccggcttt     2580

ccccgtcaag ctctaaatcg ggggctccct ttagggttcc gatttagtgc tttacggcac     2640

ctcgacccca aaaaacttga tttgggtgat ggttcacgta gtgggccatc gccctgatag     2700

acggtttttc gccctttgac gttggagtcc acgttcttta atagtggact cttgttccaa     2760

actggaacaa cactcaaccc tatctcgggc tattcttttg atttataagg gattttgccg     2820

atttcggcct attggttaaa aaatgagctg atttaacaaa aatttaacgc gaattttaac     2880

aaaatattaa cgtttacaat tttatggtgc actctcagta caatctgctc tgatgccgca     2940

tagttaagcc agccccgaca cccgccaaca cccgctgacg cgccctgacg ggcttgtctg     3000

ctcccggcat ccgcttacag acaagctgtg accgtctccg ggagctgcat gtgtcagagg     3060

ttttcaccgt catcaccgaa acgcgcgaga cgaaagggcc tcgtgatacg cctattttta     3120

taggttaatg tcatgataat aatggtttct tagacgtcag gtggcacttt tcggggaaat     3180

gtgcgcggaa cccctatttg tttatttttc taaatacatt caaatatgta tccgctcatg     3240

agacaataac cctgataaat gcttcaataa tattgaaaaa ggaagagt                  3288


<210>  17
<211>  150
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sixth stuffer sequence

<400>  17
taactgtcag accaagttta ctcatatata ctttagattg atttaaaact tcatttttaa       60

tttaaaagga tctaggtgaa gatccttttt gataatctca tgaccaaaat cccttaacgt      120

gagttttcgt tccactgagc gtcagacccc                                       150


<210>  18
<211>  11
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Seventh stuffer sequence

<400>  18
catgtacatg t                                                            11


<210>  19
<211>  816
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Kanamycin resistance gene

<400>  19
atgagccata ttcaacggga aacgtcttgc tcgaggccgc gattaaattc caacatggat       60

gctgatttat atgggtataa atgggctcgc gataatgtcg ggcaatcagg tgcgacaatc      120

tatcgattgt atgggaagcc cgatgcgcca gagttgtttc tgaaacatgg caaaggtagc      180

gttgccaatg atgttacaga tgagatggtc agactaaact ggctgacgga atttatgcct      240

cttccgacca tcaagcattt tatccgtact cctgatgatg catggttact caccactgcg      300

atccccggga aaacagcatt ccaggtatta gaagaatatc ctgattcagg tgaaaatatt      360

gttgatgcgc tggcagtgtt cctgcgccgg ttgcattcga ttcctgtttg taattgtcct      420

tttaacagcg atcgcgtatt tcgtctcgct caggcgcaat cacgaatgaa taacggtttg      480

gttgatgcga gtgattttga tgacgagcgt aatggctggc ctgttgaaca agtctggaaa      540

gaaatgcata agcttttgcc attctcaccg gattcagtcg tcactcatgg tgatttctca      600

cttgataacc ttatttttga cgaggggaaa ttaataggtt gtattgatgt tggacgagtc      660

ggaatcgcag accgatacca ggatcttgcc atcctatgga actgcctcgg tgagttttct      720

ccttcattac agaaacggct ttttcaaaaa tatggtattg ataatcctga tatgaataaa      780

ttgcagtttc atttgatgct cgatgagttt ttctaa                                816


<210>  20
<211>  668
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pUC origin

<400>  20
gtagaaaaga tcaaaggatc ttcttgagat cctttttttc tgcgcgtaat ctgctgcttg       60

caaacaaaaa aaccaccgct accagcggtg gtttgtttgc cggatcaaga gctaccaact      120

ctttttccga aggtaactgg cttcagcaga gcgcagatac caaatactgt ccttctagtg      180

tagccgtagt taggccacca cttcaagaac tctgtagcac cgcctacata cctcgctctg      240

ctaatcctgt taccagtggc tgctgccagt ggcgataagt cgtgtcttac cgggttggac      300

tcaagacgat agttaccgga taaggcgcag cggtcgggct gaacgggggg ttcgtgcaca      360

cagcccagct tggagcgaac gacctacacc gaactgagat acctacagcg tgagctatga      420

gaaagcgcca cgcttcccga agggagaaag gcggacaggt atccggtaag cggcagggtc      480

ggaacaggag agcgcacgag ggagcttcca gggggaaacg cctggtatct ttatagtcct      540

gtcgggtttc gccacctctg acttgagcgt cgatttttgt gatgctcgtc aggggggcgg      600

agcctatgga aaaacgccag caacgcggcc tttttacggt tcctggcctt ttgctggcct      660

tttgctca                                                               668


<210>  21
<211>  8853
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pCAG.wtPHGDH.WPRE.KanR

<400>  21
gaaccatcac ccaaatcaag ttttttgggg tcgaggtgcc gtaaagcact aaatcggaac       60

cctaaaggga gcccccgatt tagagcttga cggggaaagc cggcgaacgt ggcgagaaag      120

gaagggaaga aagcgaaagg agcgggcgct aaggcgctgg caagtgtagc ggtcacgctg      180

cgcgtaacca ccacacccgc cgcgcttaat gcgccgctac agggcgcgta ctatggttgc      240

tttgacgtat gcggtgtgaa ataccgcaca gatgcgtaag gagaaaatac cgcatcaggc      300

gcccctgcag gcagctgcgc gctcgctcgc tcactgaggc cgcccgggca aagcccgggc      360

gtcgggcgac ctttggtcgc ccggcctcag tgagcgagcg agcgcgcaga gagggagtgg      420

ccaactccat cactaggggt tcctgcggcc cgcgccatta ccctgttatc cctaatttaa      480

atcccgccat gctacttatc tacgtagcca tgctctaggt accattgacg tcaataatga      540

cgtatgttcc catagtaacg ccaataggga ctttccattg acgtcaatgg gtggagtatt      600

tacggtaaac tgcccacttg gcagtacatc aagtgtatca tatgccaagt acgcccccta      660

ttgacgtcaa tgacggtaaa tggcccgcct ggcattatgc ccagtacatg accttatggg      720

actttcctac ttggcagtac atctacgtat tagtcatcgc tattaccatg gtcgaggtga      780

gccccacgtt ctgcttcact ctccccatct cccccccctc cccaccccca attttgtatt      840

tatttatttt ttaattattt tgtgcagcga tgggggcggg gggggggggg gggcgcgcgc      900

caggcggggc ggggcggggc gaggggcggg gcggggcgag gcggagaggt gcggcggcag      960

ccaatcagag cggcgcgctc cgaaagtttc cttttatggc gaggcggcgg cggcggcggc     1020

cctataaaaa gcgaagcgcg cggcgggcgg gagtcgctgc gcgctgcctt cgccccgtgc     1080

cccgctccgc cgccgcctcg cgccgcccgc cccggctctg actgaccgcg ttactcccac     1140

aggtgagcgg gcgggacggc ccttctcctc cgggctgtaa ttagcgcttg gtttaatgac     1200

ggcttgtttc ttttctgtgg ctgcgtgaaa gccttgaggg gctccgggag ggccctttgt     1260

gcggggggag cggctcgggg ctgtccgcgg ggggacggct gccttcgggg gggacggggc     1320

agggcggggt tcggcttctg gcgtgtgacc ggcggctcta gagcctctgc taaccatgtt     1380

catgccttct tctttttcct acagctcctg ggcaacgtgc tggttattgt gctgtctcat     1440

cattttggca aagaattgga tcctagcttg atatcgaatt cctgcagccc ggcggcacca     1500

tggcttttgc aaatctgcgg aaagtgctca tcagtgacag cctggaccct tgctgccgga     1560

agatcttgca agatggaggg ctgcaggtgg tggaaaagca gaaccttagc aaagaggagc     1620

tgatagcgga gctgcaggac tgtgaaggcc ttattgttcg ctctgccacc aaggtgaccg     1680

ctgatgtcat caacgcagct gagaaactcc aggtggtggg cagggctggc acaggtgtgg     1740

acaatgtgga tctggaggcc gcaacaagga agggcatctt ggttatgaac acccccaatg     1800

ggaacagcct cagtgccgca gaactcactt gtggaatgat catgtgcctg gccaggcaga     1860

ttccccaggc gacggcttcg atgaaggacg gcaaatggga gcggaagaag ttcatgggaa     1920

cagagctgaa tggaaagacc ctgggaattc ttggcctggg caggattggg agagaggtag     1980

ctacccggat gcagtccttt gggatgaaga ctatagggta tgaccccatc atttccccag     2040

aggtctcggc ctcctttggt gttcagcagc tgcccctgga ggagatctgg cctctctgtg     2100

atttcatcac tgtgcacact cctctcctgc cctccacgac aggcttgctg aatgacaaca     2160

cctttgccca gtgcaagaag ggggtgcgtg tggtgaactg tgcccgtgga gggatcgtgg     2220

acgaaggcgc cctgctccgg gccctgcagt ctggccagtg tgccggggct gcactggacg     2280

tgtttacgga agagccgcca cgggaccggg ccttggtgga ccatgagaat gtcatcagct     2340

gtccccacct gggtgccagc accaaggagg ctcagagccg ctgtggggag gaaattgctg     2400

ttcagttcgt ggacatggtg aaggggaaat ctctcacggg ggttgtgaat gcccaggccc     2460

ttaccagtgc cttctctcca cacaccaagc cttggattgg tctggcagaa gctctgggga     2520

cactgatgcg agcctgggct gggtccccca aagggaccat ccaggtgata acacagggaa     2580

catccctgaa gaatgctggg aactgcctaa gccccgcagt cattgtcggc ctcctgaaag     2640

aggcttccaa gcaggcggat gtgaacttgg tgaacgctaa gctgctggtg aaagaggctg     2700

gcctcaatgt caccacctcc cacagccctg ctgcaccagg ggagcaaggc ttcggggaat     2760

gcctcctggc cgtggccctg gcaggcgccc cttaccaggc tgtgggcttg gtccaaggca     2820

ctacgcctgt actgcagggg ctcaatggag ctgtcttcag gccagaagtg cctctccgca     2880

gggacctgcc cctgctccta ttccggactc agacctctga ccctgcaatg ctgcctacca     2940

tgattggcct cctggcagag gcaggcgtgc ggctgctgtc ctaccagact tcactggtgt     3000

cagatgggga gacctggcac gtcatgggca tctcctcctt gctgcccagc ctggaagcgt     3060

ggaagcagca tgtgactgaa gccttccagt tccacttcta atctagcggc cgcgaattcg     3120

atatcaagct tatcgataat caacctctgg attacaaaat ttgtgaaaga ttgactggta     3180

ttcttaacta tgttgctcct tttacgctat gtggatacgc tgctttaatg cctttgtatc     3240

atgctattgc ttcccgtatg gctttcattt tctcctcctt gtataaatcc tggttgctgt     3300

ctctttatga ggagttgtgg cccgttgtca ggcaacgtgg cgtggtgtgc actgtgtttg     3360

ctgacgcaac ccccactggt tggggcattg ccaccacctg tcagctcctt tccgggactt     3420

tcgctttccc cctccctatt gccacggcgg aactcatcgc cgcctgcctt gcccgctgct     3480

ggacaggggc tcggctgttg ggcactgaca attccgtggt gttgtcgggg aaatcatcgt     3540

cctttccttg gctgctcgcc tgtgttgcca cctggattct gcgcgggacg tccttctgct     3600

acgtcccttc ggccctcaat ccagcggacc ttccttcccg cggcctgctg ccggctctgc     3660

ggcctcttcc gcgtcttcgc cttcgccctc agacgagtcg gatctccctt tgggccgcct     3720

ccccggcggc cgcgcaccgt cgactcgctg atcagcctcg actgtgcctt ctagttgcca     3780

gccatctgtt gtttgcccct cccccgtgcc ttccttgacc ctggaaggtg ccactcccac     3840

tgtcctttcc taataaaatg aggaaattgc atcgcattgt ctgagtaggt gtcattctat     3900

tctggggggt ggggtggggc aggacagcaa gggggaggat tgggaagaca atagcaggca     3960

tgctggggat gcggtgggct ctatggcttc tgaggcggaa agaaccagct ggggctcgac     4020

tagagcatgg ctacgtagat aagtagcatg gcgggattta aatcgctacc ttaggaccgt     4080

tatagttatc gactgaattg ccgcaggaac ccctagtgat ggagttggcc actccctctc     4140

tgcgcgctcg ctcgctcact gaggccgggc gaccaaaggt cgcccgacgc ccgggcggcc     4200

tcagtgagcg agcgagcgcg cagctgcctg caggacatga ttgtatctaa gccgtgtaat     4260

gagaacatcc acaccttagt gaatcgatgc gccgcttcgg aataccgttt tggctacctg     4320

ttactaagcc catcgcgatt ttcaggtatc gtgcacgtag ggttgcaccg cacgcatgtc     4380

gaactggtgg cgaagtacga ttccacgacc ggtgtacgat tcaactacgc ggacgtgacg     4440

agcttcttat atatgcttcg cccgccggac cggcctcgtg atggggtagc tgcgcatgag     4500

cttatgacaa ataacgagtg tgtacttgtt taatcatctc acagtgaaag tcgggagaat     4560

aggagccgct acacacattt taccgcaact acacctaact gagatactac catagatgac     4620

tacccatccc tctaggcctt agataaccgg atacagtgac tttgataggt ttgtggggta     4680

cagctatgac ttgcatagct gcgtatggag gaaggaactt ttgcgtgtta gtatgttgac     4740

ccgtgtatta cgcatgcggg tagatcatgt gggtagagac atccaggtca agttctcgac     4800

cttctcgtgg gaggtgatcc agttcactat aggaccattc cattcgagca tggcactaag     4860

tacgccgtcc ccattctggt aatcatcatc cctatcaggg tttggagtga gtggtgacgg     4920

ttattcccca ggaatggact tcttattcac agtcggtcac attgggctac tccttgggtc     4980

ttccgcttgg cccggtctgt tgggccgcca ttgcgtgagt ttcggccctg tgctgcgctg     5040

tgtcggcgat tctcattggg gcctcacatc tggaaacccc gacctatttt gacggcacca     5100

ttggcggaag ttgctgggct tgtgcaccgt gaagtcctcc gcgggcctcc cccctacaaa     5160

agacgataag ctccggcaag cagcattgat caacgcaagg atcggcgata ttaacagaga     5220

tacggctgat tactcttgtt ggtgtggtat cgctaaactg cgccgcggag ccttatggca     5280

aagtcgtccg cgaaccattc cggtagcgct taaggtccat agcacattca tcgcatcccg     5340

gcgtgcgttc aatttgacga ccccttggcg caaaggtgct ggccacgtgc taaattaaag     5400

cggctgcact gctgtaaggt ccgttacgga gagggcggcc tggggagagc actagcccat     5460

cgacctgtac aggaacactc tatattgttc tcggacggac agattactag agtgccgctt     5520

tcagcccccc tgtcgtcgcc gacgtctgta atatggcgtt gttgtgattc cactctattg     5580

aggcattaac tgatgcgtaa ggagatctgg aatgaactgg cctatgtcac tgaaactgtg     5640

caaacaccca atgtcgttag tgtaggttct gaccgatacc tgcttcgttg agaactcaca     5700

attttacaac tggggacata atccctacgc ccatcatcta ctcgcgtccc tgtggctcca     5760

gttcatgtaa tgggagagta tcctccacaa gatctagtgc tatggtggta tagtaagctc     5820

gtactgtggt agacgcgaca cgggtaggac catcagtaat aaggatagtg cgaaagctca     5880

cagaccactg cctatagggg gtgcttactt ttacaaaaag cgactgtcag tataacccca     5940

cgaggattcg aaaaggtgaa ccgacccaga cgatccggag gcacgggcct caaagccgcg     6000

acacgacggc tgtcggccgg taacagtaac cccggagtga actcctatgg ggctggatag     6060

aacagccctg gtgggcccca tcagcaaccc gaatacgtgg cttttcggga ggcggccgga     6120

ggggcgatgt cttccactat tcgaggccgt tcgttaatac ttgttgcgtt cctagccgct     6180

atatttgtct ctttgccgac taatgtggac aagcacacca tagccattta tcggagcgcc     6240

tcggaatacg gtatgagcag gcgcctcgtg agaccattgc gaataccagg tgtcctgtgg     6300

cgcctgatgc ggtattttct ccttacgcat ctgtgcggta tttcacaccg catacgtcaa     6360

agcaaccata gtacgcgccc tgtagcggcg cattaagcgc ggcgggtgtg gtggttacgc     6420

gcagcgtgac cgctacactt gccagcgccc tagcgcccgc tcctttcgct ttcttccctt     6480

cctttctcgc cacgttcgcc ggctttcccc gtcaagctct aaatcggggg ctccctttag     6540

ggttccgatt tagtgcttta cggcacctcg accccaaaaa acttgatttg ggtgatggtt     6600

cacgtagtgg gccatcgccc tgatagacgg tttttcgccc tttgacgttg gagtccacgt     6660

tctttaatag tggactcttg ttccaaactg gaacaacact caaccctatc tcgggctatt     6720

cttttgattt ataagggatt ttgccgattt cggcctattg gttaaaaaat gagctgattt     6780

aacaaaaatt taacgcgaat tttaacaaaa tattaacgtt tacaatttta tggtgcactc     6840

tcagtacaat ctgctctgat gccgcatagt taagccagcc ccgacacccg ccaacacccg     6900

ctgacgcgcc ctgacgggct tgtctgctcc cggcatccgc ttacagacaa gctgtgaccg     6960

tctccgggag ctgcatgtgt cagaggtttt caccgtcatc accgaaacgc gcgagacgaa     7020

agggcctcgt gatacgccta tttttatagg ttaatgtcat gataataatg gtttcttaga     7080

cgtcaggtgg cacttttcgg ggaaatgtgc gcggaacccc tatttgttta tttttctaaa     7140

tacattcaaa tatgtatccg ctcatgagac aataaccctg ataaatgctt caataatatt     7200

gaaaaaggaa gagtatgagc catattcaac gggaaacgtc ttgctcgagg ccgcgattaa     7260

attccaacat ggatgctgat ttatatgggt ataaatgggc tcgcgataat gtcgggcaat     7320

caggtgcgac aatctatcga ttgtatggga agcccgatgc gccagagttg tttctgaaac     7380

atggcaaagg tagcgttgcc aatgatgtta cagatgagat ggtcagacta aactggctga     7440

cggaatttat gcctcttccg accatcaagc attttatccg tactcctgat gatgcatggt     7500

tactcaccac tgcgatcccc gggaaaacag cattccaggt attagaagaa tatcctgatt     7560

caggtgaaaa tattgttgat gcgctggcag tgttcctgcg ccggttgcat tcgattcctg     7620

tttgtaattg tccttttaac agcgatcgcg tatttcgtct cgctcaggcg caatcacgaa     7680

tgaataacgg tttggttgat gcgagtgatt ttgatgacga gcgtaatggc tggcctgttg     7740

aacaagtctg gaaagaaatg cataagcttt tgccattctc accggattca gtcgtcactc     7800

atggtgattt ctcacttgat aaccttattt ttgacgaggg gaaattaata ggttgtattg     7860

atgttggacg agtcggaatc gcagaccgat accaggatct tgccatccta tggaactgcc     7920

tcggtgagtt ttctccttca ttacagaaac ggctttttca aaaatatggt attgataatc     7980

ctgatatgaa taaattgcag tttcatttga tgctcgatga gtttttctaa taactgtcag     8040

accaagttta ctcatatata ctttagattg atttaaaact tcatttttaa tttaaaagga     8100

tctaggtgaa gatccttttt gataatctca tgaccaaaat cccttaacgt gagttttcgt     8160

tccactgagc gtcagacccc gtagaaaaga tcaaaggatc ttcttgagat cctttttttc     8220

tgcgcgtaat ctgctgcttg caaacaaaaa aaccaccgct accagcggtg gtttgtttgc     8280

cggatcaaga gctaccaact ctttttccga aggtaactgg cttcagcaga gcgcagatac     8340

caaatactgt ccttctagtg tagccgtagt taggccacca cttcaagaac tctgtagcac     8400

cgcctacata cctcgctctg ctaatcctgt taccagtggc tgctgccagt ggcgataagt     8460

cgtgtcttac cgggttggac tcaagacgat agttaccgga taaggcgcag cggtcgggct     8520

gaacgggggg ttcgtgcaca cagcccagct tggagcgaac gacctacacc gaactgagat     8580

acctacagcg tgagctatga gaaagcgcca cgcttcccga agggagaaag gcggacaggt     8640

atccggtaag cggcagggtc ggaacaggag agcgcacgag ggagcttcca gggggaaacg     8700

cctggtatct ttatagtcct gtcgggtttc gccacctctg acttgagcgt cgatttttgt     8760

gatgctcgtc aggggggcgg agcctatgga aaaacgccag caacgcggcc tttttacggt     8820

tcctggcctt ttgctggcct tttgctcaca tgt                                  8853


<210>  22
<211>  8853
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pCAG.coPHGDH.WPRE.KanR

<400>  22
gaaccatcac ccaaatcaag ttttttgggg tcgaggtgcc gtaaagcact aaatcggaac       60

cctaaaggga gcccccgatt tagagcttga cggggaaagc cggcgaacgt ggcgagaaag      120

gaagggaaga aagcgaaagg agcgggcgct aaggcgctgg caagtgtagc ggtcacgctg      180

cgcgtaacca ccacacccgc cgcgcttaat gcgccgctac agggcgcgta ctatggttgc      240

tttgacgtat gcggtgtgaa ataccgcaca gatgcgtaag gagaaaatac cgcatcaggc      300

gcccctgcag gcagctgcgc gctcgctcgc tcactgaggc cgcccgggca aagcccgggc      360

gtcgggcgac ctttggtcgc ccggcctcag tgagcgagcg agcgcgcaga gagggagtgg      420

ccaactccat cactaggggt tcctgcggcc cgcgccatta ccctgttatc cctaatttaa      480

atcccgccat gctacttatc tacgtagcca tgctctaggt accattgacg tcaataatga      540

cgtatgttcc catagtaacg ccaataggga ctttccattg acgtcaatgg gtggagtatt      600

tacggtaaac tgcccacttg gcagtacatc aagtgtatca tatgccaagt acgcccccta      660

ttgacgtcaa tgacggtaaa tggcccgcct ggcattatgc ccagtacatg accttatggg      720

actttcctac ttggcagtac atctacgtat tagtcatcgc tattaccatg gtcgaggtga      780

gccccacgtt ctgcttcact ctccccatct cccccccctc cccaccccca attttgtatt      840

tatttatttt ttaattattt tgtgcagcga tgggggcggg gggggggggg gggcgcgcgc      900

caggcggggc ggggcggggc gaggggcggg gcggggcgag gcggagaggt gcggcggcag      960

ccaatcagag cggcgcgctc cgaaagtttc cttttatggc gaggcggcgg cggcggcggc     1020

cctataaaaa gcgaagcgcg cggcgggcgg gagtcgctgc gcgctgcctt cgccccgtgc     1080

cccgctccgc cgccgcctcg cgccgcccgc cccggctctg actgaccgcg ttactcccac     1140

aggtgagcgg gcgggacggc ccttctcctc cgggctgtaa ttagcgcttg gtttaatgac     1200

ggcttgtttc ttttctgtgg ctgcgtgaaa gccttgaggg gctccgggag ggccctttgt     1260

gcggggggag cggctcgggg ctgtccgcgg ggggacggct gccttcgggg gggacggggc     1320

agggcggggt tcggcttctg gcgtgtgacc ggcggctcta gagcctctgc taaccatgtt     1380

catgccttct tctttttcct acagctcctg ggcaacgtgc tggttattgt gctgtctcat     1440

cattttggca aagaattgga tcctagcttg atatcgaatt cctgcagccc ggcggcacca     1500

tggcattcgc taatctgagg aaggtgctga tctctgactc tctggacccc tgttgtcgca     1560

aaattctgca ggatggcggg ctgcaggtgg tggagaagca gaacctgagc aaggaggagc     1620

tgatcgccga gctgcaggac tgcgagggcc tgatcgtgcg gtccgccacc aaggtgacag     1680

ccgatgtgat caatgccgcc gagaagctgc aggtggtggg aagggcaggc accggcgtgg     1740

acaacgtgga tctggaggcc gccaccagaa agggcatcct ggtcatgaat acaccaaacg     1800

gcaattctct gagcgccgca gagctgacct gcggaatgat catgtgcctg gcaaggcaga     1860

tcccacaggc aacagcctct atgaaggacg gcaagtggga gagaaagaag ttcatgggca     1920

ccgagctgaa cggcaagaca ctgggcatcc tgggcctggg aaggatcgga agagaggtgg     1980

caaccagaat gcagtccttt ggcatgaaga caatcggcta cgatccaatc atctctcccg     2040

aggtgtccgc ctctttcggc gtgcagcagc tgccactgga ggagatttgg cccctgtgcg     2100

actttatcac cgtgcacaca ccactgctgc cctccaccac aggcctgctg aacgataata     2160

ccttcgccca gtgcaagaag ggcgtgaggg tggtgaattg tgccagaggc ggcatcgtgg     2220

acgagggcgc cctgctgagg gccctgcagt ccggacagtg tgcaggagcc gccctggacg     2280

tgttcaccga ggagccacct agggaccgcg ccctggtgga tcacgagaac gtgatctctt     2340

gccctcacct gggagcaagc acaaaggagg cacagtcccg ctgtggagag gagatcgccg     2400

tgcagttcgt ggacatggtg aagggcaaga gcctgaccgg agtggtgaat gcacaggccc     2460

tgacctctgc ctttagccct cacacaaagc cctggatcgg cctggcagag gccctgggca     2520

ccctgatgag ggcctgggca ggcagcccca agggcacaat ccaggtcatc acccagggca     2580

catctctgaa gaacgccggc aattgcctga gccctgccgt gatcgtgggc ctgctgaagg     2640

aggcctccaa gcaggccgat gtgaacctgg tgaatgccaa gctgctggtg aaggaggccg     2700

gcctgaacgt gaccacaagc cactcccctg cagcaccagg agagcaggga ttcggagagt     2760

gtctgctggc agtggccctg gcaggagcac cttaccaggc agtgggcctg gtgcagggca     2820

ccacaccagt gctgcagggc ctgaatggcg ccgtgttcag gccagaggtg cctctgaggc     2880

gggacctgcc actgctgctg tttcgcaccc agacatctga tcccgccatg ctgcctacca     2940

tgatcggcct gctggcagag gcaggcgtga gactgctgag ctatcagacc tccctggtgt     3000

ctgacggcga gacatggcac gtgatgggca tcagctccct gctgccatct ctggaggctt     3060

ggaagcagca tgtcaccgag gcttttcagt ttcatttcta atctagcggc cgcgaattcg     3120

atatcaagct tatcgataat caacctctgg attacaaaat ttgtgaaaga ttgactggta     3180

ttcttaacta tgttgctcct tttacgctat gtggatacgc tgctttaatg cctttgtatc     3240

atgctattgc ttcccgtatg gctttcattt tctcctcctt gtataaatcc tggttgctgt     3300

ctctttatga ggagttgtgg cccgttgtca ggcaacgtgg cgtggtgtgc actgtgtttg     3360

ctgacgcaac ccccactggt tggggcattg ccaccacctg tcagctcctt tccgggactt     3420

tcgctttccc cctccctatt gccacggcgg aactcatcgc cgcctgcctt gcccgctgct     3480

ggacaggggc tcggctgttg ggcactgaca attccgtggt gttgtcgggg aaatcatcgt     3540

cctttccttg gctgctcgcc tgtgttgcca cctggattct gcgcgggacg tccttctgct     3600

acgtcccttc ggccctcaat ccagcggacc ttccttcccg cggcctgctg ccggctctgc     3660

ggcctcttcc gcgtcttcgc cttcgccctc agacgagtcg gatctccctt tgggccgcct     3720

ccccggcggc cgcgcaccgt cgactcgctg atcagcctcg actgtgcctt ctagttgcca     3780

gccatctgtt gtttgcccct cccccgtgcc ttccttgacc ctggaaggtg ccactcccac     3840

tgtcctttcc taataaaatg aggaaattgc atcgcattgt ctgagtaggt gtcattctat     3900

tctggggggt ggggtggggc aggacagcaa gggggaggat tgggaagaca atagcaggca     3960

tgctggggat gcggtgggct ctatggcttc tgaggcggaa agaaccagct ggggctcgac     4020

tagagcatgg ctacgtagat aagtagcatg gcgggattta aatcgctacc ttaggaccgt     4080

tatagttatc gactgaattg ccgcaggaac ccctagtgat ggagttggcc actccctctc     4140

tgcgcgctcg ctcgctcact gaggccgggc gaccaaaggt cgcccgacgc ccgggcggcc     4200

tcagtgagcg agcgagcgcg cagctgcctg caggacatga ttgtatctaa gccgtgtaat     4260

gagaacatcc acaccttagt gaatcgatgc gccgcttcgg aataccgttt tggctacctg     4320

ttactaagcc catcgcgatt ttcaggtatc gtgcacgtag ggttgcaccg cacgcatgtc     4380

gaactggtgg cgaagtacga ttccacgacc ggtgtacgat tcaactacgc ggacgtgacg     4440

agcttcttat atatgcttcg cccgccggac cggcctcgtg atggggtagc tgcgcatgag     4500

cttatgacaa ataacgagtg tgtacttgtt taatcatctc acagtgaaag tcgggagaat     4560

aggagccgct acacacattt taccgcaact acacctaact gagatactac catagatgac     4620

tacccatccc tctaggcctt agataaccgg atacagtgac tttgataggt ttgtggggta     4680

cagctatgac ttgcatagct gcgtatggag gaaggaactt ttgcgtgtta gtatgttgac     4740

ccgtgtatta cgcatgcggg tagatcatgt gggtagagac atccaggtca agttctcgac     4800

cttctcgtgg gaggtgatcc agttcactat aggaccattc cattcgagca tggcactaag     4860

tacgccgtcc ccattctggt aatcatcatc cctatcaggg tttggagtga gtggtgacgg     4920

ttattcccca ggaatggact tcttattcac agtcggtcac attgggctac tccttgggtc     4980

ttccgcttgg cccggtctgt tgggccgcca ttgcgtgagt ttcggccctg tgctgcgctg     5040

tgtcggcgat tctcattggg gcctcacatc tggaaacccc gacctatttt gacggcacca     5100

ttggcggaag ttgctgggct tgtgcaccgt gaagtcctcc gcgggcctcc cccctacaaa     5160

agacgataag ctccggcaag cagcattgat caacgcaagg atcggcgata ttaacagaga     5220

tacggctgat tactcttgtt ggtgtggtat cgctaaactg cgccgcggag ccttatggca     5280

aagtcgtccg cgaaccattc cggtagcgct taaggtccat agcacattca tcgcatcccg     5340

gcgtgcgttc aatttgacga ccccttggcg caaaggtgct ggccacgtgc taaattaaag     5400

cggctgcact gctgtaaggt ccgttacgga gagggcggcc tggggagagc actagcccat     5460

cgacctgtac aggaacactc tatattgttc tcggacggac agattactag agtgccgctt     5520

tcagcccccc tgtcgtcgcc gacgtctgta atatggcgtt gttgtgattc cactctattg     5580

aggcattaac tgatgcgtaa ggagatctgg aatgaactgg cctatgtcac tgaaactgtg     5640

caaacaccca atgtcgttag tgtaggttct gaccgatacc tgcttcgttg agaactcaca     5700

attttacaac tggggacata atccctacgc ccatcatcta ctcgcgtccc tgtggctcca     5760

gttcatgtaa tgggagagta tcctccacaa gatctagtgc tatggtggta tagtaagctc     5820

gtactgtggt agacgcgaca cgggtaggac catcagtaat aaggatagtg cgaaagctca     5880

cagaccactg cctatagggg gtgcttactt ttacaaaaag cgactgtcag tataacccca     5940

cgaggattcg aaaaggtgaa ccgacccaga cgatccggag gcacgggcct caaagccgcg     6000

acacgacggc tgtcggccgg taacagtaac cccggagtga actcctatgg ggctggatag     6060

aacagccctg gtgggcccca tcagcaaccc gaatacgtgg cttttcggga ggcggccgga     6120

ggggcgatgt cttccactat tcgaggccgt tcgttaatac ttgttgcgtt cctagccgct     6180

atatttgtct ctttgccgac taatgtggac aagcacacca tagccattta tcggagcgcc     6240

tcggaatacg gtatgagcag gcgcctcgtg agaccattgc gaataccagg tgtcctgtgg     6300

cgcctgatgc ggtattttct ccttacgcat ctgtgcggta tttcacaccg catacgtcaa     6360

agcaaccata gtacgcgccc tgtagcggcg cattaagcgc ggcgggtgtg gtggttacgc     6420

gcagcgtgac cgctacactt gccagcgccc tagcgcccgc tcctttcgct ttcttccctt     6480

cctttctcgc cacgttcgcc ggctttcccc gtcaagctct aaatcggggg ctccctttag     6540

ggttccgatt tagtgcttta cggcacctcg accccaaaaa acttgatttg ggtgatggtt     6600

cacgtagtgg gccatcgccc tgatagacgg tttttcgccc tttgacgttg gagtccacgt     6660

tctttaatag tggactcttg ttccaaactg gaacaacact caaccctatc tcgggctatt     6720

cttttgattt ataagggatt ttgccgattt cggcctattg gttaaaaaat gagctgattt     6780

aacaaaaatt taacgcgaat tttaacaaaa tattaacgtt tacaatttta tggtgcactc     6840

tcagtacaat ctgctctgat gccgcatagt taagccagcc ccgacacccg ccaacacccg     6900

ctgacgcgcc ctgacgggct tgtctgctcc cggcatccgc ttacagacaa gctgtgaccg     6960

tctccgggag ctgcatgtgt cagaggtttt caccgtcatc accgaaacgc gcgagacgaa     7020

agggcctcgt gatacgccta tttttatagg ttaatgtcat gataataatg gtttcttaga     7080

cgtcaggtgg cacttttcgg ggaaatgtgc gcggaacccc tatttgttta tttttctaaa     7140

tacattcaaa tatgtatccg ctcatgagac aataaccctg ataaatgctt caataatatt     7200

gaaaaaggaa gagtatgagc catattcaac gggaaacgtc ttgctcgagg ccgcgattaa     7260

attccaacat ggatgctgat ttatatgggt ataaatgggc tcgcgataat gtcgggcaat     7320

caggtgcgac aatctatcga ttgtatggga agcccgatgc gccagagttg tttctgaaac     7380

atggcaaagg tagcgttgcc aatgatgtta cagatgagat ggtcagacta aactggctga     7440

cggaatttat gcctcttccg accatcaagc attttatccg tactcctgat gatgcatggt     7500

tactcaccac tgcgatcccc gggaaaacag cattccaggt attagaagaa tatcctgatt     7560

caggtgaaaa tattgttgat gcgctggcag tgttcctgcg ccggttgcat tcgattcctg     7620

tttgtaattg tccttttaac agcgatcgcg tatttcgtct cgctcaggcg caatcacgaa     7680

tgaataacgg tttggttgat gcgagtgatt ttgatgacga gcgtaatggc tggcctgttg     7740

aacaagtctg gaaagaaatg cataagcttt tgccattctc accggattca gtcgtcactc     7800

atggtgattt ctcacttgat aaccttattt ttgacgaggg gaaattaata ggttgtattg     7860

atgttggacg agtcggaatc gcagaccgat accaggatct tgccatccta tggaactgcc     7920

tcggtgagtt ttctccttca ttacagaaac ggctttttca aaaatatggt attgataatc     7980

ctgatatgaa taaattgcag tttcatttga tgctcgatga gtttttctaa taactgtcag     8040

accaagttta ctcatatata ctttagattg atttaaaact tcatttttaa tttaaaagga     8100

tctaggtgaa gatccttttt gataatctca tgaccaaaat cccttaacgt gagttttcgt     8160

tccactgagc gtcagacccc gtagaaaaga tcaaaggatc ttcttgagat cctttttttc     8220

tgcgcgtaat ctgctgcttg caaacaaaaa aaccaccgct accagcggtg gtttgtttgc     8280

cggatcaaga gctaccaact ctttttccga aggtaactgg cttcagcaga gcgcagatac     8340

caaatactgt ccttctagtg tagccgtagt taggccacca cttcaagaac tctgtagcac     8400

cgcctacata cctcgctctg ctaatcctgt taccagtggc tgctgccagt ggcgataagt     8460

cgtgtcttac cgggttggac tcaagacgat agttaccgga taaggcgcag cggtcgggct     8520

gaacgggggg ttcgtgcaca cagcccagct tggagcgaac gacctacacc gaactgagat     8580

acctacagcg tgagctatga gaaagcgcca cgcttcccga agggagaaag gcggacaggt     8640

atccggtaag cggcagggtc ggaacaggag agcgcacgag ggagcttcca gggggaaacg     8700

cctggtatct ttatagtcct gtcgggtttc gccacctctg acttgagcgt cgatttttgt     8760

gatgctcgtc aggggggcgg agcctatgga aaaacgccag caacgcggcc tttttacggt     8820

tcctggcctt ttgctggcct tttgctcaca tgt                                  8853


<210>  23
<211>  681
<212>  DNA
<213>  Homo sapiens

<400>  23
aacatatcct ggtgtggagt aggggacgct gctctgacag aggctcgggg gcctgagctg       60

gctctgtgag ctggggagga ggcagacagc caggccttgt ctgcaagcag acctggcagc      120

attgggctgg ccgcccccca gggcctcctc ttcatgccca gtgaatgact caccttggca      180

cagacacaat gttcggggtg ggcacagtgc ctgcttcccg ccgcacccca gcccccctca      240

aatgccttcc gagaagccca ttgagcaggg ggcttgcatt gcaccccagc ctgacagcct      300

ggcatcttgg gataaaagca gcacagcccc ctaggggctg cccttgctgt gtggcgccac      360

cggcggtgga gaacaaggct ctattcagcc tgtgcccagg aaaggggatc aggggatgcc      420

caggcatgga cagtgggtgg caggggggga gaggagggct gtctgcttcc cagaagtcca      480

aggacacaaa tgggtgaggg gagagctctc cccatagctg ggctgcggcc caaccccacc      540

ccctcaggct atgccagggg gtgttgccag gggcacccgg gcatcgccag tctagcccac      600

tccttcataa agccctcgca tcccaggagc gagcagagcc agagcaggtt ggagaggaga      660

cgcatcacct ccgctgctcg c                                                681


<210>  24
<211>  130
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Right ITR

<400>  24
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg       60

ccgggcgacc aaaggtcgcc cgacgcccgg gcggcctcag tgagcgagcg agcgcgcagc      120

tgcctgcagg                                                             130


<210>  25
<211>  77
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  First stuffer sequence

<400>  25
gcggcccgcg ccattaccct gttatcccta atttaaatcc cgccatgcta cttatctacg       60

tagccatgct ctaggta                                                      77


<210>  26
<211>  90
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fourth stuffer sequence

<400>  26
ctcgactaga gcatggctac gtagataagt agcatggcgg gatttaaatc gctaccttag       60

gaccgttata gttatcgact gaattgccgc                                        90


<210>  27
<211>  2980
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fifth suffer sequence

<400>  27
acatgattgt atctaagccg tgtaatgaga acatccacac cttagtgaat cgatgcgccg       60

cttcggaata ccgttttggc tacctgttac taagcccatc gcgattttca ggtatcgtgc      120

acgtagggtt gcaccgcacg catgtcgaac tggtggcgaa gtacgattcc acgaccggtg      180

tacgattcaa ctacgcggac gtgacgagct tcttatatat gcttcgcccg ccggaccggc      240

ctcgtgatgg ggtagctgcg catgagctta tgacaaataa cgagtgtgta cttgtttaat      300

catctcacag tgaaagtcgg gagaatagga gccgctacac acattttacc gcaactacac      360

ctaactgaga tactaccata gatgactacc catccctcta ggccttagat aaccggatac      420

agtgactttg ataggtttgt ggggtacagc tatgacttgc atagctgcgt atggaggaag      480

gaacttttgc gtgttagtat gttgacccgt gtattacgca tgcgggtaga tcatgtgggt      540

agagacatcc aggtcaagtt ctcgaccttc tcgtgggagg tgatccagtt cactatagga      600

ccattccatt cgagcatggc actaagtacg ccgtccccat tctggtaatc atcatcccta      660

tcagggtttg gagtgagtgg tgacggttat tccccaggaa tggacttctt attcacagtc      720

ggtcacattg ggctactcct tgggtcttcc gcttggcccg gtctgttggg ccgccattgc      780

gtgagtttcg gccctgtgct gcgctgtgtc ggcgattctc attggggcct cacatctgga      840

aaccccgacc tattttgacg gcaccattgg cggaagttgc tgggcttgtg caccgtgaag      900

tcctccgcgg gcctcccccc tacaaaagac gataagctcc ggcaagcagc attgatcaac      960

gcaaggatcg gcgatattaa cagagatacg gctgattact cttgttggtg tggtatcgct     1020

aaactgcgcc gcggagcctt atggcaaagt cgtccgcgaa ccattccggt agcgcttaag     1080

gtccatagca cattcatcgc atcccggcgt gcgttcaatt tgacgacccc ttggcgcaaa     1140

ggtgctggcc acgtgctaaa ttaaagcggc tgcactgctg taaggtccgt tacggagagg     1200

gcggcctggg gagagcacta gcccatcgac ctgtacagga acactctata ttgttctcgg     1260

acggacagat tactagagtg ccgctttcag cccccctgtc gtcgccgacg tctgtaatat     1320

ggcgttgttg tgattccact ctattgaggc attaactgat gcgtaaggag atctggaatg     1380

aactggccta tgtcactgaa actgtgcaaa cacccaatgt cgttagtgta ggttctgacc     1440

gatacctgct tcgttgagaa ctcacaattt tacaactggg gacataatcc ctacgcccat     1500

catctactcg cgtccctgtg gctccagttc atgtaatggg agagtatcct ccacaagatc     1560

tagtgctatg gtggtatagt aagctcgtac tgtggtagac gcgacacggg taggaccatc     1620

agtaataagg atagtgcgaa agctcacaga ccactgccta tagggggtgc ttacttttac     1680

aaaaagcgac tgtcagtata accccacgag gattcgaaaa ggtgaaccga cccagacgat     1740

ccggaggcac gggcctcaaa gccgcgacac gacggctgtc ggccggtaac agtaaccccg     1800

gagtgaactc ctatggggct ggatagaaca gccctggtgg gccccatcag caacccgaat     1860

acgtggcttt tcgggaggcg gccggagggg cgatgtcttc cactattcga ggccgttcgt     1920

taatacttgt tgcgttccta gccgctatat ttgtctcttt gccgactaat gtggacaagc     1980

acaccatagc catttatcgg agcgcctcgg aatacggtat gagcaggcgc ctcgtgagac     2040

cattgcgaat accaggtgtc ctgtggcgcc tgatgcggta ttttctcctt acgcatctgt     2100

gcggtatttc acaccgcata cgtcaaagca accatagtac gcgccctgta gcggcgcatt     2160

aagcgcggcg ggtgtggtgg ttacgcgcag cgtgaccgct acacttgcca gcgccctagc     2220

gcccgctcct ttcgctttct tcccttcctt tctcgccacg ttcgccggct ttccccgtca     2280

agctctaaat cgggggctcc ctttagggtt ccgatttagt gctttacggc acctcgaccc     2340

caaaaaactt gatttgggtg atggttcacg tagtgggcca tcgccctgat agacggtttt     2400

tcgccctttg acgttggagt ccacgttctt taatagtgga ctcttgttcc aaactggaac     2460

aacactcaac cctatctcgg gctattcttt tgatttataa gggattttgc cgatttcggc     2520

ctattggtta aaaaatgagc tgatttaaca aaaatttaac gcgaatttta acaaaatatt     2580

aacgtttaca attttatggt gcactctcag tacaatctgc tctgatgccg catagttaag     2640

ccagccccga cacccgccaa cacccgctga cgcgccctga cgggcttgtc tgctcccggc     2700

atccgcttac agacaagctg tgaccgtctc cgggagctgc atgtgtcaga ggttttcacc     2760

gtcatcaccg aaacgcgcga gacgaaaggg cctcgtgata cgcctatttt tataggttaa     2820

tgtcatgata ataatggttt cttagacgtc aggtggcact tttcggggaa atgtgcgcgg     2880

aacccctatt tgtttatttt tctaaataca ttcaaatatg tatccgctca tgagacaata     2940

accctgataa atgcttcaat aatattgaaa aaggaagagt                           2980


