                         SEQUENCE LISTING



<110>  Virogin Biotech Canada Ltd. 

       Virogin Biotech (Shanghai) Ltd.

       

<120>  Multivalent Recombinant ACE2 and Uses Thereof



<130>  VIRO414



<160>  9     



<170>  PatentIn version 3.5



<210>  1

<211>  598

<212>  PRT

<213>  Homo sapiens



<400>  1



Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Asn 

1               5                   10                  15      





His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn 

            20                  25                  30          





Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala 

        35                  40                  45              





Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln 

    50                  55                  60                  





Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln Leu 

65                  70                  75                  80  





Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser 

                85                  90                  95      





Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr 

            100                 105                 110         





Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu 

        115                 120                 125             





Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg 

    130                 135                 140                 





Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg 

145                 150                 155                 160 





Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala 

                165                 170                 175     





Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val 

            180                 185                 190         





Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp 

        195                 200                 205             





Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His 

    210                 215                 220                 





Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser 

225                 230                 235                 240 





Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg 

                245                 250                 255     





Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro 

            260                 265                 270         





Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln 

        275                 280                 285             





Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro 

    290                 295                 300                 





Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro Gly 

305                 310                 315                 320 





Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys 

                325                 330                 335     





Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe 

            340                 345                 350         





Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr 

        355                 360                 365             





Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His 

    370                 375                 380                 





Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His 

385                 390                 395                 400 





Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu 

                405                 410                 415     





Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr 

            420                 425                 430         





Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys 

        435                 440                 445             





Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys 

    450                 455                 460                 





Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr 

465                 470                 475                 480 





Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile 

                485                 490                 495     





Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu 

            500                 505                 510         





Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser 

        515                 520                 525             





Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly 

    530                 535                 540                 





Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys 

545                 550                 555                 560 





Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr 

                565                 570                 575     





Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp 

            580                 585                 590         





Trp Ser Pro Tyr Ala Asp 

        595             





<210>  2

<211>  224

<212>  PRT

<213>  Homo sapiens



<400>  2



Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser 

1               5                   10                  15      





Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 

            20                  25                  30          





Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro 

        35                  40                  45              





Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 

    50                  55                  60                  





Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val 

65                  70                  75                  80  





Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 

                85                  90                  95      





Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr 

            100                 105                 110         





Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 

        115                 120                 125             





Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 

    130                 135                 140                 





Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 

145                 150                 155                 160 





Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 

                165                 170                 175     





Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser 

            180                 185                 190         





Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 

        195                 200                 205             





Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 

    210                 215                 220                 





<210>  3

<211>  18

<212>  PRT

<213>  Homo sapiens



<400>  3



Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Ile Leu Lys Gly 

1               5                   10                  15      





Val Gln 

        





<210>  4

<211>  15

<212>  PRT

<213>  Homo sapiens



<400>  4



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 

1               5                   10                  15  





<210>  5

<211>  12

<212>  PRT

<213>  Homo sapiens



<400>  5



Gly Ser Ala Gly Ser Ala Ala Gly Ser Gly Glu Phe 

1               5                   10          





<210>  6

<211>  9

<212>  PRT

<213>  Homo sapiens



<400>  6



Gly Gly Ser Gly Gly Gly Ser Gly Gly 

1               5                   





<210>  7

<211>  12

<212>  PRT

<213>  Homo sapiens



<400>  7



Lys Arg Val Ala Pro Glu Leu Leu Gly Gly Pro Ser 

1               5                   10          





<210>  8

<211>  846

<212>  PRT

<213>  Homo sapiens



<400>  8



Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Ile Leu Lys Gly 

1               5                   10                  15      





Val Gln Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys 

            20                  25                  30          





Phe Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser 

        35                  40                  45              





Trp Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn 

    50                  55                  60                  





Asn Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu 

65                  70                  75                  80  





Ala Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu 

                85                  90                  95      





Gln Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp 

            100                 105                 110         





Lys Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr 

        115                 120                 125             





Ser Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu 

    130                 135                 140                 





Leu Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn 

145                 150                 155                 160 





Glu Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln 

                165                 170                 175     





Leu Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala 

            180                 185                 190         





Arg Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr 

        195                 200                 205             





Glu Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile 

    210                 215                 220                 





Glu Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His 

225                 230                 235                 240 





Leu His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr 

                245                 250                 255     





Ile Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp 

            260                 265                 270         





Gly Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln 

        275                 280                 285             





Lys Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp 

    290                 295                 300                 





Ala Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly 

305                 310                 315                 320 





Leu Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp 

                325                 330                 335     





Pro Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu 

            340                 345                 350         





Gly Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp 

        355                 360                 365             





Asp Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met 

    370                 375                 380                 





Ala Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly 

385                 390                 395                 400 





Phe His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro 

                405                 410                 415     





Lys His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp 

            420                 425                 430         





Asn Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val 

        435                 440                 445             





Gly Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val 

    450                 455                 460                 





Phe Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu 

465                 470                 475                 480 





Met Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu 

                485                 490                 495     





Thr Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser 

            500                 505                 510         





Phe Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu 

        515                 520                 525             





Ala Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp 

    530                 535                 540                 





Ile Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg 

545                 550                 555                 560 





Leu Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly 

                565                 570                 575     





Ala Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu 

            580                 585                 590         





Phe Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser 

        595                 600                 605             





Thr Asp Trp Ser Pro Tyr Ala Asp Pro Asn Pro Leu Leu Gly Pro Pro 

    610                 615                 620                 





Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 

625                 630                 635                 640 





Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 

                645                 650                 655     





Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 

            660                 665                 670         





Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 

        675                 680                 685             





Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 

    690                 695                 700                 





Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 

705                 710                 715                 720 





Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 

                725                 730                 735     





Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 

            740                 745                 750         





Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 

        755                 760                 765             





Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 

    770                 775                 780                 





Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 

785                 790                 795                 800 





Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 

                805                 810                 815     





Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 

            820                 825                 830         





Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 

        835                 840                 845     





<210>  9

<211>  1464

<212>  PRT

<213>  Homo sapiens



<400>  9



Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Ile Leu Lys Gly 

1               5                   10                  15      





Val Gln Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys 

            20                  25                  30          





Phe Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser 

        35                  40                  45              





Trp Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn 

    50                  55                  60                  





Asn Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu 

65                  70                  75                  80  





Ala Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu 

                85                  90                  95      





Gln Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp 

            100                 105                 110         





Lys Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr 

        115                 120                 125             





Ser Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu 

    130                 135                 140                 





Leu Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn 

145                 150                 155                 160 





Glu Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln 

                165                 170                 175     





Leu Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala 

            180                 185                 190         





Arg Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr 

        195                 200                 205             





Glu Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile 

    210                 215                 220                 





Glu Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His 

225                 230                 235                 240 





Leu His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr 

                245                 250                 255     





Ile Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp 

            260                 265                 270         





Gly Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln 

        275                 280                 285             





Lys Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp 

    290                 295                 300                 





Ala Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly 

305                 310                 315                 320 





Leu Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp 

                325                 330                 335     





Pro Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu 

            340                 345                 350         





Gly Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp 

        355                 360                 365             





Asp Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met 

    370                 375                 380                 





Ala Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly 

385                 390                 395                 400 





Phe His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro 

                405                 410                 415     





Lys His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp 

            420                 425                 430         





Asn Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val 

        435                 440                 445             





Gly Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val 

    450                 455                 460                 





Phe Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu 

465                 470                 475                 480 





Met Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu 

                485                 490                 495     





Thr Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser 

            500                 505                 510         





Phe Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu 

        515                 520                 525             





Ala Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp 

    530                 535                 540                 





Ile Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg 

545                 550                 555                 560 





Leu Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly 

                565                 570                 575     





Ala Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu 

            580                 585                 590         





Phe Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser 

        595                 600                 605             





Thr Asp Trp Ser Pro Tyr Ala Asp Pro Asn Pro Leu Leu Gly Pro Pro 

    610                 615                 620                 





Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 

625                 630                 635                 640 





Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 

                645                 650                 655     





Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 

            660                 665                 670         





Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 

        675                 680                 685             





Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 

    690                 695                 700                 





Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 

705                 710                 715                 720 





Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 

                725                 730                 735     





Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 

            740                 745                 750         





Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 

        755                 760                 765             





Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 

    770                 775                 780                 





Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 

785                 790                 795                 800 





Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 

                805                 810                 815     





Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 

            820                 825                 830         





Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Thr Cys 

        835                 840                 845             





Gly Ala Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 

    850                 855                 860                 





Gly Ser Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys 

865                 870                 875                 880 





Phe Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser 

                885                 890                 895     





Trp Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn 

            900                 905                 910         





Asn Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu 

        915                 920                 925             





Ala Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu 

    930                 935                 940                 





Gln Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp 

945                 950                 955                 960 





Lys Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr 

                965                 970                 975     





Ser Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu 

            980                 985                 990         





Leu Glu Pro Gly Leu Asn Glu Ile  Met Ala Asn Ser Leu  Asp Tyr Asn 

        995                 1000                 1005             





Glu Arg  Leu Trp Ala Trp Glu  Ser Trp Arg Ser Glu  Val Gly Lys 

    1010                 1015                 1020             





Gln Leu  Arg Pro Leu Tyr Glu  Glu Tyr Val Val Leu  Lys Asn Glu 

    1025                 1030                 1035             





Met Ala  Arg Ala Asn His Tyr  Glu Asp Tyr Gly Asp  Tyr Trp Arg 

    1040                 1045                 1050             





Gly Asp  Tyr Glu Val Asn Gly  Val Asp Gly Tyr Asp  Tyr Ser Arg 

    1055                 1060                 1065             





Gly Gln  Leu Ile Glu Asp Val  Glu His Thr Phe Glu  Glu Ile Lys 

    1070                 1075                 1080             





Pro Leu  Tyr Glu His Leu His  Ala Tyr Val Arg Ala  Lys Leu Met 

    1085                 1090                 1095             





Asn Ala  Tyr Pro Ser Tyr Ile  Ser Pro Ile Gly Cys  Leu Pro Ala 

    1100                 1105                 1110             





His Leu  Leu Gly Asp Met Trp  Gly Arg Phe Trp Thr  Asn Leu Tyr 

    1115                 1120                 1125             





Ser Leu  Thr Val Pro Phe Gly  Gln Lys Pro Asn Ile  Asp Val Thr 

    1130                 1135                 1140             





Asp Ala  Met Val Asp Gln Ala  Trp Asp Ala Gln Arg  Ile Phe Lys 

    1145                 1150                 1155             





Glu Ala  Glu Lys Phe Phe Val  Ser Val Gly Leu Pro  Asn Met Thr 

    1160                 1165                 1170             





Gln Gly  Phe Trp Glu Asn Ser  Met Leu Thr Asp Pro  Gly Asn Val 

    1175                 1180                 1185             





Gln Lys  Ala Val Cys His Pro  Thr Ala Trp Asp Leu  Gly Lys Gly 

    1190                 1195                 1200             





Asp Phe  Arg Ile Leu Met Cys  Thr Lys Val Thr Met  Asp Asp Phe 

    1205                 1210                 1215             





Leu Thr  Ala His His Glu Met  Gly His Ile Gln Tyr  Asp Met Ala 

    1220                 1225                 1230             





Tyr Ala  Ala Gln Pro Phe Leu  Leu Arg Asn Gly Ala  Asn Glu Gly 

    1235                 1240                 1245             





Phe His  Glu Ala Val Gly Glu  Ile Met Ser Leu Ser  Ala Ala Thr 

    1250                 1255                 1260             





Pro Lys  His Leu Lys Ser Ile  Gly Leu Leu Ser Pro  Asp Phe Gln 

    1265                 1270                 1275             





Glu Asp  Asn Glu Thr Glu Ile  Asn Phe Leu Leu Lys  Gln Ala Leu 

    1280                 1285                 1290             





Thr Ile  Val Gly Thr Leu Pro  Phe Thr Tyr Met Leu  Glu Lys Trp 

    1295                 1300                 1305             





Arg Trp  Met Val Phe Lys Gly  Glu Ile Pro Lys Asp  Gln Trp Met 

    1310                 1315                 1320             





Lys Lys  Trp Trp Glu Met Lys  Arg Glu Ile Val Gly  Val Val Glu 

    1325                 1330                 1335             





Pro Val  Pro His Asp Glu Thr  Tyr Cys Asp Pro Ala  Ser Leu Phe 

    1340                 1345                 1350             





His Val  Ser Asn Asp Tyr Ser  Phe Ile Arg Tyr Tyr  Thr Arg Thr 

    1355                 1360                 1365             





Leu Tyr  Gln Phe Gln Phe Gln  Glu Ala Leu Cys Gln  Ala Ala Lys 

    1370                 1375                 1380             





His Glu  Gly Pro Leu His Lys  Cys Asp Ile Ser Asn  Ser Thr Glu 

    1385                 1390                 1395             





Ala Gly  Gln Lys Leu Phe Asn  Met Leu Arg Leu Gly  Lys Ser Glu 

    1400                 1405                 1410             





Pro Trp  Thr Leu Ala Leu Glu  Asn Val Val Gly Ala  Lys Asn Met 

    1415                 1420                 1425             





Asn Val  Arg Pro Leu Leu Asn  Tyr Phe Glu Pro Leu  Phe Thr Trp 

    1430                 1435                 1440             





Leu Lys  Asp Gln Asn Lys Asn  Ser Phe Val Gly Trp  Ser Thr Asp 

    1445                 1450                 1455             





Trp Ser  Pro Tyr Ala Asp 

    1460                 





