                         SEQUENCE LISTING

<110>  Ĵײ̩ҽҩɷ޹˾
 
<120>  һ໯ѧżӼ;

<130>  IEC210181PCT

<150>  202110615166.4
<151>  2021-06-02

<150>  202111225483.1
<151>  2021-10-21

<160>  19    

<170>  PatentIn version 3.5

<210>  1
<211>  118
<212>  PRT
<213>  artificial

<220>
<223>  VH of 19F6_Hu35V1

<400>  1

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          


Tyr Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile Ser Tyr Ser Gly Ser Ile Arg Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Glu Ile Thr Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  2
<211>  107
<212>  PRT
<213>  artificial

<220>
<223>  VL of 19F6_Hu35V1

<400>  2

Glu Thr Thr Leu Thr Gln Ser Pro Ala Phe Met Ser Ala Thr Pro Gly 
1               5                   10                  15      


Asp Lys Val Thr Ile Ser Cys Lys Ala Ser Thr Ser Ile Asp Asp Asp 
            20                  25                  30          


Met Asn Trp Tyr Gln Gln Lys Pro Gly Glu Pro Pro Lys Leu Ile Ile 
        35                  40                  45              


Ser Glu Gly Asn Thr Leu Arg Pro Gly Ile Pro Pro Arg Phe Ser Ser 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Asp Phe Thr Phe Thr Ile Asn Lys Ile Lys Ser 
65                  70                  75                  80  


Glu Asp Ala Ala Thr Tyr Tyr Cys Leu Gln Ser Asn Asp Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  3
<211>  8
<212>  PRT
<213>  artificial

<220>
<223>  Chothia CDR H1 of 19F6_Hu35V1

<400>  3

Gly Tyr Ser Ile Thr Ser Asp Tyr 
1               5               


<210>  4
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  Chothia CDR H2 of 19F6_Hu35V1

<400>  4

Ser Tyr Ser Gly Ser 
1               5   


<210>  5
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  Chothia/Abm/Kabat CDR H3 of 19F6_Hu35V1

<400>  5

Gly Glu Ile Thr Tyr Tyr Phe Asp Tyr 
1               5                   


<210>  6
<211>  11
<212>  PRT
<213>  artificial

<220>
<223>  Chothia/Abm/Kabat CDR L1 of 19F6_Hu35V1

<400>  6

Lys Ala Ser Thr Ser Ile Asp Asp Asp Met Asn 
1               5                   10      


<210>  7
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  Chothia/Abm/Kabat CDRL2 of 19F6_Hu35V1

<400>  7

Glu Gly Asn Thr Leu Arg Pro 
1               5           


<210>  8
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  Chothia/Abm/Kabat/IMGT CDR L3 of 19F6_Hu35V1

<400>  8

Leu Gln Ser Asn Asp Leu Pro Leu Thr 
1               5                   


<210>  9
<211>  11
<212>  PRT
<213>  artificial

<220>
<223>  Abm CDR H1 of 19F6_Hu35V1

<400>  9

Gly Tyr Ser Ile Thr Ser Asp Tyr Ala Trp Asn 
1               5                   10      


<210>  10
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  Abm CDR H2 of 19F6_Hu35V1

<400>  10

Tyr Ile Ser Tyr Ser Gly Ser Ile Arg 
1               5                   


<210>  11
<211>  6
<212>  PRT
<213>  artificial

<220>
<223>  Kabat CDR H1 of 19F6_Hu35V1

<400>  11

Ser Asp Tyr Ala Trp Asn 
1               5       


<210>  12
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  Kabat CDR H2 of 19F6_Hu35V1

<400>  12

Tyr Ile Ser Tyr Ser Gly Ser Ile Arg Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  13
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  IMGT CDR H1 of 19F6_Hu35V1

<400>  13

Gly Tyr Ser Ile Thr Ser Asp Tyr Ala 
1               5                   


<210>  14
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  IMGT CDR H2 of 19F6_Hu35V1

<400>  14

Ile Ser Tyr Ser Gly Ser Ile 
1               5           


<210>  15
<211>  11
<212>  PRT
<213>  artificial

<220>
<223>  IMGT CDR H3 of 19F6_Hu35V1

<400>  15

Ala Arg Gly Glu Ile Thr Tyr Tyr Phe Asp Tyr 
1               5                   10      


<210>  16
<211>  6
<212>  PRT
<213>  artificial

<220>
<223>  IMGT CDR L1 of 19F6_Hu35V1

<400>  16

Thr Ser Ile Asp Asp Asp 
1               5       


<210>  17
<211>  3
<212>  PRT
<213>  artificial

<220>
<223>  IMGT CDR L2 of 19F6_Hu35V1

<400>  17

Glu Gly Asn 
1           


<210>  18
<211>  330
<212>  PRT
<213>  artificial

<220>
<223>  CH of 19F6_Hu35V1

<400>  18

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  19
<211>  107
<212>  PRT
<213>  artificial

<220>
<223>  CL of 19F6_Hu35V1

<400>  19

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


