                         SEQUENCE LISTING

<110>  йũҵѧ
 
<120>  Type I-C CRISPR-Cas3ϵͳӦ

<130>  IEC210182PCT

<150>  CN202110620180.3
<151>  2021-06-03

<160>  69    

<170>  PatentIn version 3.5

<210>  1
<211>  745
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I-CCas3װ

<400>  1

Met Ala Asp Gly Gly Asp Glu His Ala Ser Gly His Asp Asn Thr Leu 
1               5                   10                  15      


Lys Asn Ala Arg Tyr Tyr Ala His Ser Thr Pro Asn Pro Asp Lys Ser 
            20                  25                  30          


Asp Trp Gln Gly Leu Asp Ala His Leu Glu Asn Val Ala Asn Leu Ala 
        35                  40                  45              


Ala Thr Phe Ala Glu Ala Phe Gly Ala Arg Glu Trp Gly Lys Ala Ala 
    50                  55                  60                  


Gly Leu Leu His Asp Ala Gly Lys Ala Thr Ala Gln Phe Thr Gln Arg 
65                  70                  75                  80  


Leu Glu Gly Arg Pro Val Arg Val Asn His Ser Ile Cys Gly Ala Arg 
                85                  90                  95      


Leu Ala Gln Glu Gln Gly Ser Thr Cys Gly Leu Leu Leu Ser Tyr Ala 
            100                 105                 110         


Ile Ala Gly His His Gly Gly Leu Pro Asp Gly Gly Leu Gln Asp Gly 
        115                 120                 125             


Gln Leu His His Arg Leu Lys His Glu Arg Leu Pro Ala Asp Val Ser 
    130                 135                 140                 


Pro Pro Ser Val Asp Ile Arg Pro Asp Val Leu Lys Pro Pro Phe Thr 
145                 150                 155                 160 


Cys Arg Pro Glu His Pro Gly Phe Ser Leu Ser Phe Phe Thr Arg Met 
                165                 170                 175     


Leu Phe Ser Cys Leu Thr Asp Ala Asp Phe Leu Asp Thr Glu Ala Phe 
            180                 185                 190         


Cys Thr Pro Glu Lys Ala Ser Ala Arg Asn Gly Arg Ser Ala Leu Gly 
        195                 200                 205             


Leu Val Ala Leu Arg Asp Ala Leu Asn Thr His Leu Asp Thr Val Glu 
    210                 215                 220                 


Arg Lys Ala Leu Pro Ser Arg Val Asn Asp Ile Arg Lys Thr Val Leu 
225                 230                 235                 240 


His Asp Cys Arg Ala Arg Ala Ser Glu Thr Pro Gly Leu Phe Ser Leu 
                245                 250                 255     


Thr Val Pro Thr Gly Gly Gly Lys Thr Leu Ser Ser Met Ala Phe Ala 
            260                 265                 270         


Leu Asp His Ala Val Thr His Gly Leu Arg Arg Val Ile Tyr Ala Ile 
        275                 280                 285             


Pro Phe Thr Ser Ile Ile Glu Gln Asn Ala Lys Val Phe Ser Asp Val 
    290                 295                 300                 


Phe Gly Gln Asp Asn Val Leu Glu His His Cys Asn Tyr Arg Ser Lys 
305                 310                 315                 320 


Asp Glu Pro Glu Glu Gln Gly Tyr Asp Lys Trp Arg Gly Leu Ala Ala 
                325                 330                 335     


Glu Asn Trp Asp Ala Pro Val Val Val Thr Thr Asn Val Gln Phe Phe 
            340                 345                 350         


Glu Ser Leu Phe Ser Asn Arg Pro Ser Arg Cys Arg Lys Leu His Asn 
        355                 360                 365             


Ile Ala Arg Ser Val Ile Val Leu Asp Glu Ala Gln Ala Ile Pro Thr 
    370                 375                 380                 


Glu Tyr Leu Glu Pro Cys Leu Tyr Ala Leu Lys Glu Leu Val Gly Gln 
385                 390                 395                 400 


Tyr Gly Cys Thr Val Val Leu Cys Thr Ala Thr Gln Pro Ala Val Asp 
                405                 410                 415     


Asp Ala Ser Leu Pro Glu Arg Val Arg Leu His His Val Arg Glu Ile 
            420                 425                 430         


Ile Ala Asp Pro Gln Arg Leu Tyr Thr Asp Leu Lys Arg Thr Glu Val 
        435                 440                 445             


Thr Leu Ala Gly Arg Leu Thr Asp Ala Ala Leu Ala Ala Arg Leu Asp 
    450                 455                 460                 


Gly His Gly Gln Val Leu Cys Ile Val Gly Thr Lys Pro Gln Ala Gln 
465                 470                 475                 480 


Ala Val Phe Ser Leu Leu Gln Glu Arg Glu Gly Ala Phe His Leu Ser 
                485                 490                 495     


Thr Asn Met Tyr Pro Glu His Arg Arg Arg Val Leu Gly Thr Ile Arg 
            500                 505                 510         


Gln Arg Leu Ala Asp Arg Leu Pro Cys Arg Val Val Ser Thr Ser Leu 
        515                 520                 525             


Ile Glu Ala Gly Val Asp Val Asp Phe Pro Val Val Tyr Arg Ala Met 
    530                 535                 540                 


Ala Gly Leu Asp Ser Ile Ala Gln Ala Ala Gly Arg Cys Asn Arg Glu 
545                 550                 555                 560 


Gly Arg Leu Pro Glu Pro Gly Gln Val Val Val Tyr Glu Pro Glu Lys 
                565                 570                 575     


Pro Ala Arg Met Pro Trp Met Gln Arg Cys Ala Ser Arg Ala Gln Glu 
            580                 585                 590         


Thr Leu Arg Thr Leu Pro Glu Ala Asp Pro Leu Gly Leu Glu Ala Ile 
        595                 600                 605             


Arg Arg Tyr Phe Gly Leu Ile Tyr Asp Val Gln Glu Leu Asp Arg Lys 
    610                 615                 620                 


Asp Ile Phe Lys Arg Leu Arg Gly Gln Val Asp Arg Asp Met Val Phe 
625                 630                 635                 640 


Lys Phe Arg Glu Ile Ala Asn Asp Phe Arg Phe Ile Asp Asp Glu Gly 
                645                 650                 655     


Thr Ala Leu Val Ile Pro Thr Gly Pro Glu Val Glu Asp Leu Val Arg 
            660                 665                 670         


Arg Leu Arg Gly Cys Glu Phe Pro Arg Pro Val Leu Arg Lys Leu Gln 
        675                 680                 685             


Gln Tyr Ser Val Thr Val Arg His Arg Glu Leu Glu Lys Leu Arg Ser 
    690                 695                 700                 


Ala Gly Ala Val Glu Met Ile Gly Asp Ala Tyr Pro Val Leu Arg Asn 
705                 710                 715                 720 


Leu Ala Ala Tyr Ser Glu Asp Met Gly Leu Cys Val Asp Ser Val Glu 
                725                 730                 735     


Val Trp Gln Pro Glu Gly Leu Val Ser 
            740                 745 


<210>  2
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I-C Cas5c׵İ

<400>  2

Met Thr His Gly Ala Val Lys Thr Tyr Gly Ile Arg Leu Arg Val Trp 
1               5                   10                  15      


Gly Asp Tyr Ala Cys Phe Thr Arg Pro Glu Met Lys Val Glu Arg Val 
            20                  25                  30          


Ser Tyr Asp Val Met Pro Pro Ser Ala Ala Arg Gly Ile Leu Glu Ala 
        35                  40                  45              


Ile His Trp Lys Pro Ala Ile Arg Trp Ile Val Asp Arg Ile His Val 
    50                  55                  60                  


Leu Arg Pro Ile Val Phe Asp Asn Val Arg Arg Asn Glu Val Ser Ser 
65                  70                  75                  80  


Lys Ile Pro Lys Pro Asn Pro Ala Thr Ala Met Arg Asp Arg Lys Pro 
                85                  90                  95      


Leu Tyr Phe Leu Val Asp Asp Gly Ser Asn Arg Gln Gln Arg Ala Ala 
            100                 105                 110         


Thr Leu Leu Arg Asn Val Asp Tyr Val Ile Glu Ala His Phe Glu Leu 
        115                 120                 125             


Thr Asp Lys Ala Gly Ala Glu Asp Asn Ala Gly Lys His Leu Asp Ile 
    130                 135                 140                 


Phe Arg Arg Arg Ala Arg Ala Gly Gln Ser Phe Gln Gln Pro Cys Leu 
145                 150                 155                 160 


Gly Cys Arg Glu Phe Pro Ala Ser Phe Glu Leu Leu Glu Gly Asp Val 
                165                 170                 175     


Pro Leu Ser Cys Tyr Ala Gly Glu Lys Arg Asp Leu Gly Tyr Met Leu 
            180                 185                 190         


Leu Asp Ile Asp Phe Glu Arg Asp Met Thr Pro Leu Phe Phe Lys Ala 
        195                 200                 205             


Val Met Glu Asp Gly Val Ile Thr Pro Pro Ser Arg Thr Ser Pro Glu 
    210                 215                 220                 


Val Arg Ala 
225         


<210>  3
<211>  612
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I-C Cas8c׵İ

<400>  3

Met Ile Leu Gln Ala Leu His Gly Tyr Tyr Gln Arg Met Ser Ala Asp 
1               5                   10                  15      


Pro Asp Ala Gly Met Pro Pro Tyr Gly Thr Ser Met Glu Asn Ile Ser 
            20                  25                  30          


Phe Ala Leu Val Leu Asp Ala Lys Gly Thr Leu Arg Gly Ile Glu Asp 
        35                  40                  45              


Leu Arg Glu Gln Glu Gly Lys Lys Leu Arg Pro Arg Lys Met Leu Val 
    50                  55                  60                  


Pro Ile Ala Glu Lys Lys Gly Asn Gly Ile Lys Pro Asn Phe Leu Trp 
65                  70                  75                  80  


Glu Asn Thr Ser Tyr Ile Leu Gly Val Asp Ala Lys Gly Lys Gln Glu 
                85                  90                  95      


Arg Thr Asp Lys Cys His Ala Ala Phe Ile Ala His Ile Lys Ala Tyr 
            100                 105                 110         


Cys Asp Thr Ala Asp Gln Asp Leu Ala Ala Val Leu Gln Phe Leu Glu 
        115                 120                 125             


His Gly Glu Lys Asp Leu Ser Ala Phe Pro Val Ser Glu Glu Val Ile 
    130                 135                 140                 


Gly Ser Asn Ile Val Phe Arg Ile Glu Gly Glu Pro Gly Phe Val His 
145                 150                 155                 160 


Glu Arg Pro Ala Ala Arg Gln Ala Trp Ala Asn Cys Leu Asn Arg Arg 
                165                 170                 175     


Glu Gln Gly Leu Cys Gly Gln Cys Leu Ile Thr Gly Glu Arg Gln Lys 
            180                 185                 190         


Pro Ile Ala Gln Leu His Pro Ser Ile Lys Gly Gly Arg Asp Gly Val 
        195                 200                 205             


Arg Gly Ala Gln Ala Val Ala Ser Ile Val Ser Phe Asn Asn Thr Ala 
    210                 215                 220                 


Phe Glu Ser Tyr Gly Lys Glu Gln Ser Ile Asn Ala Pro Val Ser Gln 
225                 230                 235                 240 


Glu Ala Ala Phe Ser Tyr Val Thr Ala Leu Asn Tyr Leu Leu Asn Pro 
                245                 250                 255     


Ser Asn Arg Gln Lys Val Thr Ile Ala Asp Ala Thr Val Val Phe Trp 
            260                 265                 270         


Ala Glu Arg Ser Ser Pro Ala Glu Asp Ile Phe Ala Gly Met Phe Asp 
        275                 280                 285             


Pro Pro Ser Thr Thr Ala Lys Pro Glu Ser Ser Asn Gly Thr Pro Pro 
    290                 295                 300                 


Glu Asp Ser Glu Glu Gly Ser Gln Pro Asp Thr Ala Arg Asp Asp Pro 
305                 310                 315                 320 


His Ala Ala Ala Arg Met His Asp Leu Leu Val Ala Ile Arg Ser Gly 
                325                 330                 335     


Lys Arg Ala Thr Asp Ile Met Pro Asp Met Asp Glu Ser Val Arg Phe 
            340                 345                 350         


His Val Leu Gly Leu Ser Pro Asn Ala Ala Arg Leu Ser Val Arg Phe 
        355                 360                 365             


Trp Glu Val Asp Thr Val Gly His Met Leu Asp Lys Val Gly Arg His 
    370                 375                 380                 


Tyr Arg Glu Leu Glu Ile Ile Pro Gln Phe Asn Asn Glu Gln Glu Phe 
385                 390                 395                 400 


Pro Ser Leu Ser Thr Leu Leu Arg Gln Thr Ala Val Leu Asn Lys Thr 
                405                 410                 415     


Glu Asn Ile Ser Pro Val Leu Ala Gly Gly Leu Phe Arg Ala Met Leu 
            420                 425                 430         


Thr Gly Gly Pro Tyr Pro Gln Ser Leu Leu Pro Ala Val Leu Gly Arg 
        435                 440                 445             


Ile Arg Ala Glu His Ala Arg Pro Glu Asp Lys Ser Arg Tyr Arg Leu 
    450                 455                 460                 


Glu Val Val Thr Tyr Tyr Arg Ala Ala Leu Ile Lys Ala Tyr Leu Ile 
465                 470                 475                 480 


Arg Asn Arg Lys Leu Glu Val Pro Val Ser Leu Asp Pro Ala Arg Thr 
                485                 490                 495     


Asp Arg Pro Tyr Leu Leu Gly Arg Leu Phe Ala Val Leu Glu Lys Ala 
            500                 505                 510         


Gln Glu Asp Ala Val Pro Gly Ala Asn Ala Thr Ile Lys Asp Arg Tyr 
        515                 520                 525             


Leu Ala Ser Ala Ser Ala Asn Pro Gly Gln Val Phe His Met Leu Leu 
    530                 535                 540                 


Lys Asn Ala Ser Asn His Thr Ala Lys Leu Arg Lys Asp Pro Glu Arg 
545                 550                 555                 560 


Lys Gly Ser Ala Ile His Tyr Glu Ile Met Met Gln Glu Ile Ile Asp 
                565                 570                 575     


Asn Ile Ser Asp Phe Pro Val Thr Met Ser Ser Asp Glu Gln Gly Leu 
            580                 585                 590         


Phe Met Ile Gly Tyr Tyr His Gln Arg Lys Ala Leu Phe Thr Lys Lys 
        595                 600                 605             


Asn Lys Glu Asn 
    610         


<210>  4
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I-C Cas7׵İ

<400>  4

Met Thr Ala Ile Ala Asn Arg Tyr Glu Phe Val Leu Leu Phe Asp Val 
1               5                   10                  15      


Glu Asn Gly Asn Pro Asn Gly Asp Pro Asp Ala Gly Asn Met Pro Arg 
            20                  25                  30          


Ile Asp Pro Glu Thr Gly His Gly Leu Val Thr Asp Val Cys Leu Lys 
        35                  40                  45              


Arg Lys Ile Arg Asn His Val Ala Leu Thr Lys Glu Gly Ala Glu Arg 
    50                  55                  60                  


Phe Asn Ile Tyr Ile Gln Glu Lys Ala Ile Leu Asn Glu Thr His Glu 
65                  70                  75                  80  


Arg Ala Tyr Thr Ala Cys Asp Leu Lys Pro Glu Pro Lys Lys Leu Pro 
                85                  90                  95      


Lys Lys Val Glu Asp Ala Lys Arg Val Thr Asp Trp Met Cys Thr Asn 
            100                 105                 110         


Phe Tyr Asp Ile Arg Thr Phe Gly Ala Val Met Thr Thr Glu Val Asn 
        115                 120                 125             


Cys Gly Gln Val Arg Gly Pro Val Gln Met Ala Phe Ala Arg Ser Val 
    130                 135                 140                 


Glu Pro Val Val Pro Gln Glu Val Ser Ile Thr Arg Met Ala Val Thr 
145                 150                 155                 160 


Thr Lys Ala Glu Ala Glu Lys Gln Gln Gly Asp Asn Arg Thr Met Gly 
                165                 170                 175     


Arg Lys His Ile Val Pro Tyr Gly Leu Tyr Val Ala His Gly Phe Ile 
            180                 185                 190         


Ser Ala Pro Leu Ala Glu Lys Thr Gly Phe Ser Asp Glu Asp Leu Thr 
        195                 200                 205             


Leu Phe Trp Asp Ala Leu Val Asn Met Phe Glu His Asp Arg Ser Ala 
    210                 215                 220                 


Ala Arg Gly Leu Met Ser Ser Arg Lys Leu Ile Val Phe Lys His Gln 
225                 230                 235                 240 


Asn Arg Leu Gly Asn Ala Pro Ala His Lys Leu Phe Asp Leu Val Lys 
                245                 250                 255     


Val Ser Arg Ala Glu Gly Ser Ser Gly Pro Ala Arg Ser Phe Ala Asp 
            260                 265                 270         


Tyr Ala Val Thr Val Gly Gln Ala Pro Glu Gly Val Glu Val Lys Glu 
        275                 280                 285             


Met Leu 
    290 


<210>  5
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I-C Cas11c׵İ

<400>  5

Met Val Ser Leu Asp Pro Ala Arg Thr Asp Arg Pro Tyr Leu Leu Gly 
1               5                   10                  15      


Arg Leu Phe Ala Val Leu Glu Lys Ala Gln Glu Asp Ala Val Pro Gly 
            20                  25                  30          


Ala Asn Ala Thr Ile Lys Asp Arg Tyr Leu Ala Ser Ala Ser Ala Asn 
        35                  40                  45              


Pro Gly Gln Val Phe His Met Leu Leu Lys Asn Ala Ser Asn His Thr 
    50                  55                  60                  


Ala Lys Leu Arg Lys Asp Pro Glu Arg Lys Gly Ser Ala Ile His Tyr 
65                  70                  75                  80  


Glu Ile Met Met Gln Glu Ile Ile Asp Asn Ile Ser Asp Phe Pro Val 
                85                  90                  95      


Thr Met Ser Ser Asp Glu Gln Gly Leu Phe Met Ile Gly Tyr Tyr His 
            100                 105                 110         


Gln Arg Lys Ala Leu Phe Thr Lys Lys Asn Lys Glu Asn 
        115                 120                 125 


<210>  6
<211>  2235
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  I-C Cas3ĺ

<400>  6
atggcagatg ggggggatga gcatgctagc ggccacgaca atacgctcaa aaacgcgagg       60

tactatgcgc attctacgcc gaatcccgac aaatcggact ggcagggtct ggatgctcat      120

ctggaaaacg ttgctaacct tgctgctaca tttgccgagg cgttcggggc gcgggagtgg      180

ggcaaggcag caggactatt acatgacgcc ggcaaagcta ccgcgcagtt cactcagcgc      240

cttgagggcc gcccagttcg cgtcaatcat tcaatatgtg gcgcacggtt ggcccaagaa      300

cagggttcaa catgcgggct tctactcagt tatgccatag ccggacatca cggagggtta      360

cctgacggcg gcctccagga tgggcagctt caccaccgtc tgaagcatga acgcttaccc      420

gcggatgttt cgccaccgag cgtggatatc cggccagacg tccttaagcc gccatttacc      480

tgtcgcccgg aacacccagg cttctccctc agcttcttca caaggatgct cttctcatgt      540

ctcactgacg cagatttcct cgacaccgaa gcattctgca cgccggagaa ggccagcgcc      600

aggaacggaa gatcagcact tggtctggtg gcccttaggg acgcactcaa cactcatcta      660

gataccgtgg aaaggaaggc actcccctcg cgagtgaatg atattcgtaa gacagttcta      720

cacgactgcc gtgctagagc gagtgagaca ccaggccttt tctcgctcac tgtaccaact      780

ggtgggggaa agacgctttc ctccatggcc ttcgcgttgg accacgccgt gacgcacggg      840

ctccgccgcg tgatatatgc tattcccttc acgtcgatca ttgaacaaaa tgcgaaggtg      900

ttcagcgatg ttttcggcca agataatgtt ctggagcacc attgcaacta caggtcaaaa      960

gatgaacctg aagagcaggg atacgacaag tggcgtggat tggcggccga gaattgggat     1020

gctccagtag tcgtcactac taatgtgcaa ttttttgagt ctttattttc caaccgcccg     1080

tcacgctgca gaaagctgca caacatcgct agaagcgtca tcgttctcga cgaggcacaa     1140

gccatcccaa ccgagtacct ggagccttgc ttatatgcac tcaaggagct agttggccag     1200

tacggctgca ccgtcgttct ctgtaccgca acgcagccgg cggtcgacga cgccagtctt     1260

ccagagcgcg tgcggcttca tcatgtgagg gagattattg ccgaccctca acgcctgtac     1320

accgacctca aaagaactga ggtcacactg gcgggccgcc taacagatgc ggcgctggcc     1380

gcgcgattgg acggtcatgg acaggtcttg tgcatagtag gcaccaagcc gcaagcacaa     1440

gccgtgtttt ctctcctgca ggagcgggag ggtgcctttc acttgtcaac aaacatgtat     1500

ccggaacacc gccgtagggt tcttggcacc ataagacaac gcttagcgga ccggcttcct     1560

tgccgagtgg tatctacatc tcttattgag gcaggcgttg atgtagactt tcccgtggtc     1620

taccgagcta tggctggact ggacagtatc gctcaggcgg cgggacgctg caacagagaa     1680

ggtagactgc ctgaacctgg ccaggtcgtt gtttatgagc ccgaaaaacc cgctagaatg     1740

ccatggatgc agagatgcgc ctccagagcc caagaaacgc tgcgtacttt gcccgaagca     1800

gacccgctcg gtttagaggc cataaggcgg tactttggcc taatttatga tgtgcaggaa     1860

ttggatagga aagacatctt caagaggctg cgtgggcagg ttgaccggga catggttttt     1920

aaatttaggg aaatcgctaa tgatttcagg ttcatcgacg acgagggcac agctttggtc     1980

attcctaccg gtcctgaagt agaggatctg gtccggcgac tacgcgggtg tgagttcccg     2040

cggcctgtat tgaggaagct gcagcaatat tctgtgacgg tgaggcacag ggagctcgag     2100

aagctgcggt cggctggtgc cgtcgagatg atcggggatg cttatcccgt cctgcgcaac     2160

ctggcggcat actccgaaga catgggtctc tgtgttgatt ctgtggaggt gtggcaaccg     2220

gaggggcttg tgtcc                                                      2235


<210>  7
<211>  681
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  I-C Cas5cĺ

<400>  7
atgacccatg gggctgtcaa gacatacggc atcagactgc gcgtgtgggg ggactatgcc       60

tgcttcaccc ggccggagat gaaggttgag agggtctctt atgatgttat gccgccgtca      120

gctgccaggg gcattctgga ggccatccac tggaagcctg caataagatg gattgtcgac      180

cgcatacatg ttcttcgacc tattgtgttt gacaacgtga ggaggaatga agtctctagc      240

aagatcccta aaccaaatcc agcaactgct atgcgtgaca ggaagcccct gtacttcctg      300

gtggacgatg gctcgaaccg acaacaacgc gctgcaacac tccttcgcaa tgtagattat      360

gtgattgagg cgcacttcga gcttactgat aaagcggggg ctgaagataa cgcagggaag      420

cacttagaca tcttcaggag gcgcgcgaga gctggacaga gcttccagca gccttgcctc      480

ggctgtagag aatttccggc gtcatttgag ctactcgaag gtgatgtccc gttgtcctgc      540

tacgccggcg agaagcggga tttgggatac atgctgttgg acatagattt tgaaagagac      600

atgacgcccc tcttcttcaa ggcggtcatg gaggacggcg ttatcacccc tcccagccgg      660

acgtccccag aggtgcgcgc c                                                681


<210>  8
<211>  1836
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  I-C Cas8cĺ

<400>  8
atgatcctcc aagccctcca tggatactat caacgcatgt ccgctgatcc tgacgccggc       60

atgccgccgt acggaacgtc catggaaaat atttccttcg cgctggtcct cgatgccaag      120

ggcaccctgc ggggcatcga ggacctgcgc gaacaagagg gcaagaagct gaggccaaga      180

aagatgttgg tgccgattgc agagaagaaa ggaaacggga taaagcccaa cttcctctgg      240

gagaatactt catacatcct tggcgtggat gcaaaaggaa agcaagaacg gactgataag      300

tgccatgctg cattcatcgc gcacattaag gcgtactgcg acacagctga ccaggatctg      360

gccgccgttc tgcaatttct agagcacggc gaaaaagatc tgagcgcctt ccccgtgtca      420

gaagaagtta tcggaagcaa cattgtcttc cggatcgaag gtgagcccgg tttcgtccac      480

gagcgtccag cggctaggca ggcgtgggcg aactgcctga acaggcgtga acagggcctt      540

tgtggtcagt gcctcataac tggagaacgg caaaagccaa ttgcacagct ccacccttcc      600

atcaaaggcg ggagagatgg agtcaggggt gctcaggccg tggctagtat tgtatccttc      660

aacaatacag cgtttgagtc gtatggaaaa gaacagtcta taaatgcacc tgtaagtcag      720

gaggccgcct tttcttatgt tactgcgctt aactaccttt taaacccgtc gaaccgacag      780

aaggtaacta tagcggacgc aacagttgtt ttttgggctg aacgttcatc gccggcggag      840

gatatttttg cagggatgtt tgatccacct tcaacaacgg cgaaaccgga gagttctaac      900

ggtacgcctc cagaagattc tgaggagggg tcgcaaccgg acacggcaag agacgacccg      960

cacgctgctg cccgcatgca cgacctcctc gtggccatcc gcagtggcaa acgcgcaaca     1020

gacatcatgc ccgacatgga cgagagcgtc agattccatg ttctgggcct ttcaccaaat     1080

gctgcgcgcc tcagcgtgcg cttctgggag gtggacacag tggggcacat gctggacaaa     1140

gttgggcgcc attaccgcga gctggagatc atcccccagt tcaacaacga gcaagaattt     1200

ccttctttgt caaccctgct gcggcagact gccgtcctaa ataaaacaga aaacatctcg     1260

ccggttttgg ccgggggact ctttcgagca atgctcacag gtggccccta cccccagagc     1320

ctgttgcccg cagtcctggg aaggatcagg gcagaacacg ccaggccaga agacaagtca     1380

cgttaccgac ttgaggttgt gacctattat cgcgcggcct tgataaaagc ctatttgata     1440

aggaacagga aattagaagt ccctgtaagc cttgatcctg cgcgaacaga caggccttat     1500

ttacttggcc ggctgtttgc tgttctggag aaagcgcagg aggacgcggt gccgggcgcc     1560

aacgctacca ttaaggatcg ctacctggcg tctgcttcag ccaatcctgg acaagtgttc     1620

cacatgctac tgaagaatgc ctccaaccat actgctaagc tgagaaaaga tcccgagagg     1680

aaggggtcag caatccacta cgagataatg atgcaggaaa ttatagataa tataagcgac     1740

ttccctgtca caatgagctc tgatgaacaa gggctattta tgattggcta ttaccatcag     1800

aggaaggccc tcttcaccaa gaagaacaag gagaat                               1836


<210>  9
<211>  870
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  I-C Cas7ĺ

<400>  9
atgactgcca tcgccaatcg gtacgagttt gtgctcttat ttgatgttga gaatgggaac       60

ccaaatggag atcctgatgc tggcaacatg ccgcgcattg acccggagac cggccacggc      120

cttgttacag atgtatgcct caaaagaaaa ataaggaacc atgtggccct caccaaggaa      180

ggcgccgaga ggttcaacat ctacatccag gagaaagcaa tattgaatga gactcatgaa      240

agagcttata cagcctgcga cctgaagcct gagcccaaga aactgccaaa aaaagtggag      300

gacgccaagc gcgtaacgga ctggatgtgc acaaacttct acgacatccg cacttttggc      360

gcggtcatga ccacggaggt caactgtggt caagttagag ggccggtgca gatggccttc      420

gcacggagcg tagaacctgt ggtgccacaa gaggtgtcca taacaaggat ggcagtcacg      480

acgaaggctg aagcagagaa gcagcagggt gataatcgta ccatgggccg caagcatatt      540

gtcccctatg gtctctacgt cgctcacgga tttatttccg cgccgctagc agaaaaaact      600

ggattcagtg atgaagatct aaccctgttc tgggacgcgc tggtgaatat gtttgagcat      660

gaccgctcag ctgcccgagg tttgatgagt tctcgaaaac ttatcgtgtt caagcaccag      720

aacaggctcg gcaatgcacc agcgcacaag ctgttcgacc tggtcaaggt ttctcgtgcg      780

gagggttcaa gcggccccgc gcgtagcttc gccgactatg ctgttactgt tggccaggcg      840

cctgaaggag ttgaagttaa agagatgttg                                       870


<210>  10
<211>  375
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  I-C Cas11cĺ

<400>  10
atggtaagcc ttgatcctgc gcgaacagac aggccttatt tacttggccg gctgtttgct       60

gttctggaga aagcgcagga ggacgcggtg ccgggcgcca acgctaccat taaggatcgc      120

tacctggcgt ctgcttcagc caatcctgga caagtgttcc acatgctact gaagaatgcc      180

tccaaccata ctgctaagct gagaaaagat cccgagagga aggggtcagc aatccactac      240

gagataatga tgcaggaaat tatagataat ataagcgact tccctgtcac aatgagctct      300

gatgaacaag ggctatttat gattggctat taccatcaga ggaaggccct cttcaccaag      360

aagaacaagg agaat                                                       375


<210>  11
<211>  32
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  I-Cԭͬظ

<400>  11
gucgcccccc acgcgggggc guggauugaa ac                                     32


<210>  12
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  I-Cԭͬظеĺ

<400>  12
gtcgcccccc acgcgggggc gtggattgaa ac                                     32


<210>  13
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  I-Cͬظ-ṹĵһ

<400>  13
gucgcccccc acgcgggggc g                                                 21


<210>  14
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  I-Cͬظ-ṹĵڶ

<400>  14
uggauugaaa c                                                            11


<210>  15
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLS

<400>  15

Met Pro Lys Lys Lys Arg Lys Val 
1               5               


<210>  16
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker-1 

<400>  16

Gly Ile His Gly Val Pro Ala Ala Gly Ser 
1               5                   10  


<210>  17
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker-2

<400>  17

Gly Ser Gly 
1           


<210>  18
<211>  782
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLS-(linker 1)-(I-C Cas3)ںϵ׵İ

<400>  18

Met Pro Lys Lys Lys Arg Lys Val Gly Ile His Gly Val Pro Ala Ala 
1               5                   10                  15      


Gly Ser Ala Asp Gly Gly Asp Glu His Ala Ser Gly His Asp Asn Thr 
            20                  25                  30          


Leu Lys Asn Ala Arg Tyr Tyr Ala His Ser Thr Pro Asn Pro Asp Lys 
        35                  40                  45              


Ser Asp Trp Gln Gly Leu Asp Ala His Leu Glu Asn Val Ala Asn Leu 
    50                  55                  60                  


Ala Ala Thr Phe Ala Glu Ala Phe Gly Ala Arg Glu Trp Gly Lys Ala 
65                  70                  75                  80  


Ala Gly Leu Leu His Asp Ala Gly Lys Ala Thr Ala Gln Phe Thr Gln 
                85                  90                  95      


Arg Leu Glu Gly Arg Pro Val Arg Val Asn His Ser Ile Cys Gly Ala 
            100                 105                 110         


Arg Leu Ala Gln Glu Gln Gly Ser Thr Cys Gly Leu Leu Leu Ser Tyr 
        115                 120                 125             


Ala Ile Ala Gly His His Gly Gly Leu Pro Asp Gly Gly Leu Gln Asp 
    130                 135                 140                 


Gly Gln Leu His His Arg Leu Lys His Glu Arg Leu Pro Ala Asp Val 
145                 150                 155                 160 


Ser Pro Pro Ser Val Asp Ile Arg Pro Asp Val Leu Lys Pro Pro Phe 
                165                 170                 175     


Thr Cys Arg Pro Glu His Pro Gly Phe Ser Leu Ser Phe Phe Thr Arg 
            180                 185                 190         


Met Leu Phe Ser Cys Leu Thr Asp Ala Asp Phe Leu Asp Thr Glu Ala 
        195                 200                 205             


Phe Cys Thr Pro Glu Lys Ala Ser Ala Arg Asn Gly Arg Ser Ala Leu 
    210                 215                 220                 


Gly Leu Val Ala Leu Arg Asp Ala Leu Asn Thr His Leu Asp Thr Val 
225                 230                 235                 240 


Glu Arg Lys Ala Leu Pro Ser Arg Val Asn Asp Ile Arg Lys Thr Val 
                245                 250                 255     


Leu His Asp Cys Arg Ala Arg Ala Ser Glu Thr Pro Gly Leu Phe Ser 
            260                 265                 270         


Leu Thr Val Pro Thr Gly Gly Gly Lys Thr Leu Ser Ser Met Ala Phe 
        275                 280                 285             


Ala Leu Asp His Ala Val Thr His Gly Leu Arg Arg Val Ile Tyr Ala 
    290                 295                 300                 


Ile Pro Phe Thr Ser Ile Ile Glu Gln Asn Ala Lys Val Phe Ser Asp 
305                 310                 315                 320 


Val Phe Gly Gln Asp Asn Val Leu Glu His His Cys Asn Tyr Arg Ser 
                325                 330                 335     


Lys Asp Glu Pro Glu Glu Gln Gly Tyr Asp Lys Trp Arg Gly Leu Ala 
            340                 345                 350         


Ala Glu Asn Trp Asp Ala Pro Val Val Val Thr Thr Asn Val Gln Phe 
        355                 360                 365             


Phe Glu Ser Leu Phe Ser Asn Arg Pro Ser Arg Cys Arg Lys Leu His 
    370                 375                 380                 


Asn Ile Ala Arg Ser Val Ile Val Leu Asp Glu Ala Gln Ala Ile Pro 
385                 390                 395                 400 


Thr Glu Tyr Leu Glu Pro Cys Leu Tyr Ala Leu Lys Glu Leu Val Gly 
                405                 410                 415     


Gln Tyr Gly Cys Thr Val Val Leu Cys Thr Ala Thr Gln Pro Ala Val 
            420                 425                 430         


Asp Asp Ala Ser Leu Pro Glu Arg Val Arg Leu His His Val Arg Glu 
        435                 440                 445             


Ile Ile Ala Asp Pro Gln Arg Leu Tyr Thr Asp Leu Lys Arg Thr Glu 
    450                 455                 460                 


Val Thr Leu Ala Gly Arg Leu Thr Asp Ala Ala Leu Ala Ala Arg Leu 
465                 470                 475                 480 


Asp Gly His Gly Gln Val Leu Cys Ile Val Gly Thr Lys Pro Gln Ala 
                485                 490                 495     


Gln Ala Val Phe Ser Leu Leu Gln Glu Arg Glu Gly Ala Phe His Leu 
            500                 505                 510         


Ser Thr Asn Met Tyr Pro Glu His Arg Arg Arg Val Leu Gly Thr Ile 
        515                 520                 525             


Arg Gln Arg Leu Ala Asp Arg Leu Pro Cys Arg Val Val Ser Thr Ser 
    530                 535                 540                 


Leu Ile Glu Ala Gly Val Asp Val Asp Phe Pro Val Val Tyr Arg Ala 
545                 550                 555                 560 


Met Ala Gly Leu Asp Ser Ile Ala Gln Ala Ala Gly Arg Cys Asn Arg 
                565                 570                 575     


Glu Gly Arg Leu Pro Glu Pro Gly Gln Val Val Val Tyr Glu Pro Glu 
            580                 585                 590         


Lys Pro Ala Arg Met Pro Trp Met Gln Arg Cys Ala Ser Arg Ala Gln 
        595                 600                 605             


Glu Thr Leu Arg Thr Leu Pro Glu Ala Asp Pro Leu Gly Leu Glu Ala 
    610                 615                 620                 


Ile Arg Arg Tyr Phe Gly Leu Ile Tyr Asp Val Gln Glu Leu Asp Arg 
625                 630                 635                 640 


Lys Asp Ile Phe Lys Arg Leu Arg Gly Gln Val Asp Arg Asp Met Val 
                645                 650                 655     


Phe Lys Phe Arg Glu Ile Ala Asn Asp Phe Arg Phe Ile Asp Asp Glu 
            660                 665                 670         


Gly Thr Ala Leu Val Ile Pro Thr Gly Pro Glu Val Glu Asp Leu Val 
        675                 680                 685             


Arg Arg Leu Arg Gly Cys Glu Phe Pro Arg Pro Val Leu Arg Lys Leu 
    690                 695                 700                 


Gln Gln Tyr Ser Val Thr Val Arg His Arg Glu Leu Glu Lys Leu Arg 
705                 710                 715                 720 


Ser Ala Gly Ala Val Glu Met Ile Gly Asp Ala Tyr Pro Val Leu Arg 
                725                 730                 735     


Asn Leu Ala Ala Tyr Ser Glu Asp Met Gly Leu Cys Val Asp Ser Val 
            740                 745                 750         


Glu Val Trp Gln Pro Glu Gly Leu Val Ser Gly Ser Gly Ser Lys Arg 
        755                 760                 765             


Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys Lys 
    770                 775                 780         


<210>  19
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLS-(linker 2)-(I-C Cas5c)ںϵ׵İ

<400>  19

Met Pro Lys Lys Lys Arg Lys Val Gly Ser Gly Thr His Gly Ala Val 
1               5                   10                  15      


Lys Thr Tyr Gly Ile Arg Leu Arg Val Trp Gly Asp Tyr Ala Cys Phe 
            20                  25                  30          


Thr Arg Pro Glu Met Lys Val Glu Arg Val Ser Tyr Asp Val Met Pro 
        35                  40                  45              


Pro Ser Ala Ala Arg Gly Ile Leu Glu Ala Ile His Trp Lys Pro Ala 
    50                  55                  60                  


Ile Arg Trp Ile Val Asp Arg Ile His Val Leu Arg Pro Ile Val Phe 
65                  70                  75                  80  


Asp Asn Val Arg Arg Asn Glu Val Ser Ser Lys Ile Pro Lys Pro Asn 
                85                  90                  95      


Pro Ala Thr Ala Met Arg Asp Arg Lys Pro Leu Tyr Phe Leu Val Asp 
            100                 105                 110         


Asp Gly Ser Asn Arg Gln Gln Arg Ala Ala Thr Leu Leu Arg Asn Val 
        115                 120                 125             


Asp Tyr Val Ile Glu Ala His Phe Glu Leu Thr Asp Lys Ala Gly Ala 
    130                 135                 140                 


Glu Asp Asn Ala Gly Lys His Leu Asp Ile Phe Arg Arg Arg Ala Arg 
145                 150                 155                 160 


Ala Gly Gln Ser Phe Gln Gln Pro Cys Leu Gly Cys Arg Glu Phe Pro 
                165                 170                 175     


Ala Ser Phe Glu Leu Leu Glu Gly Asp Val Pro Leu Ser Cys Tyr Ala 
            180                 185                 190         


Gly Glu Lys Arg Asp Leu Gly Tyr Met Leu Leu Asp Ile Asp Phe Glu 
        195                 200                 205             


Arg Asp Met Thr Pro Leu Phe Phe Lys Ala Val Met Glu Asp Gly Val 
    210                 215                 220                 


Ile Thr Pro Pro Ser Arg Thr Ser Pro Glu Val Arg Ala 
225                 230                 235         


<210>  20
<211>  300
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLS-(linker 2)-(I-C Cas7)ںϵ׵İ

<400>  20

Met Pro Lys Lys Lys Arg Lys Val Gly Ser Gly Thr Ala Ile Ala Asn 
1               5                   10                  15      


Arg Tyr Glu Phe Val Leu Leu Phe Asp Val Glu Asn Gly Asn Pro Asn 
            20                  25                  30          


Gly Asp Pro Asp Ala Gly Asn Met Pro Arg Ile Asp Pro Glu Thr Gly 
        35                  40                  45              


His Gly Leu Val Thr Asp Val Cys Leu Lys Arg Lys Ile Arg Asn His 
    50                  55                  60                  


Val Ala Leu Thr Lys Glu Gly Ala Glu Arg Phe Asn Ile Tyr Ile Gln 
65                  70                  75                  80  


Glu Lys Ala Ile Leu Asn Glu Thr His Glu Arg Ala Tyr Thr Ala Cys 
                85                  90                  95      


Asp Leu Lys Pro Glu Pro Lys Lys Leu Pro Lys Lys Val Glu Asp Ala 
            100                 105                 110         


Lys Arg Val Thr Asp Trp Met Cys Thr Asn Phe Tyr Asp Ile Arg Thr 
        115                 120                 125             


Phe Gly Ala Val Met Thr Thr Glu Val Asn Cys Gly Gln Val Arg Gly 
    130                 135                 140                 


Pro Val Gln Met Ala Phe Ala Arg Ser Val Glu Pro Val Val Pro Gln 
145                 150                 155                 160 


Glu Val Ser Ile Thr Arg Met Ala Val Thr Thr Lys Ala Glu Ala Glu 
                165                 170                 175     


Lys Gln Gln Gly Asp Asn Arg Thr Met Gly Arg Lys His Ile Val Pro 
            180                 185                 190         


Tyr Gly Leu Tyr Val Ala His Gly Phe Ile Ser Ala Pro Leu Ala Glu 
        195                 200                 205             


Lys Thr Gly Phe Ser Asp Glu Asp Leu Thr Leu Phe Trp Asp Ala Leu 
    210                 215                 220                 


Val Asn Met Phe Glu His Asp Arg Ser Ala Ala Arg Gly Leu Met Ser 
225                 230                 235                 240 


Ser Arg Lys Leu Ile Val Phe Lys His Gln Asn Arg Leu Gly Asn Ala 
                245                 250                 255     


Pro Ala His Lys Leu Phe Asp Leu Val Lys Val Ser Arg Ala Glu Gly 
            260                 265                 270         


Ser Ser Gly Pro Ala Arg Ser Phe Ala Asp Tyr Ala Val Thr Val Gly 
        275                 280                 285             


Gln Ala Pro Glu Gly Val Glu Val Lys Glu Met Leu 
    290                 295                 300 


<210>  21
<211>  622
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLS-(linker 2)-(I-C Cas8c)ںϵ׵İ

<400>  21

Met Pro Lys Lys Lys Arg Lys Val Gly Ser Gly Ile Leu Gln Ala Leu 
1               5                   10                  15      


His Gly Tyr Tyr Gln Arg Met Ser Ala Asp Pro Asp Ala Gly Met Pro 
            20                  25                  30          


Pro Tyr Gly Thr Ser Met Glu Asn Ile Ser Phe Ala Leu Val Leu Asp 
        35                  40                  45              


Ala Lys Gly Thr Leu Arg Gly Ile Glu Asp Leu Arg Glu Gln Glu Gly 
    50                  55                  60                  


Lys Lys Leu Arg Pro Arg Lys Met Leu Val Pro Ile Ala Glu Lys Lys 
65                  70                  75                  80  


Gly Asn Gly Ile Lys Pro Asn Phe Leu Trp Glu Asn Thr Ser Tyr Ile 
                85                  90                  95      


Leu Gly Val Asp Ala Lys Gly Lys Gln Glu Arg Thr Asp Lys Cys His 
            100                 105                 110         


Ala Ala Phe Ile Ala His Ile Lys Ala Tyr Cys Asp Thr Ala Asp Gln 
        115                 120                 125             


Asp Leu Ala Ala Val Leu Gln Phe Leu Glu His Gly Glu Lys Asp Leu 
    130                 135                 140                 


Ser Ala Phe Pro Val Ser Glu Glu Val Ile Gly Ser Asn Ile Val Phe 
145                 150                 155                 160 


Arg Ile Glu Gly Glu Pro Gly Phe Val His Glu Arg Pro Ala Ala Arg 
                165                 170                 175     


Gln Ala Trp Ala Asn Cys Leu Asn Arg Arg Glu Gln Gly Leu Cys Gly 
            180                 185                 190         


Gln Cys Leu Ile Thr Gly Glu Arg Gln Lys Pro Ile Ala Gln Leu His 
        195                 200                 205             


Pro Ser Ile Lys Gly Gly Arg Asp Gly Val Arg Gly Ala Gln Ala Val 
    210                 215                 220                 


Ala Ser Ile Val Ser Phe Asn Asn Thr Ala Phe Glu Ser Tyr Gly Lys 
225                 230                 235                 240 


Glu Gln Ser Ile Asn Ala Pro Val Ser Gln Glu Ala Ala Phe Ser Tyr 
                245                 250                 255     


Val Thr Ala Leu Asn Tyr Leu Leu Asn Pro Ser Asn Arg Gln Lys Val 
            260                 265                 270         


Thr Ile Ala Asp Ala Thr Val Val Phe Trp Ala Glu Arg Ser Ser Pro 
        275                 280                 285             


Ala Glu Asp Ile Phe Ala Gly Met Phe Asp Pro Pro Ser Thr Thr Ala 
    290                 295                 300                 


Lys Pro Glu Ser Ser Asn Gly Thr Pro Pro Glu Asp Ser Glu Glu Gly 
305                 310                 315                 320 


Ser Gln Pro Asp Thr Ala Arg Asp Asp Pro His Ala Ala Ala Arg Met 
                325                 330                 335     


His Asp Leu Leu Val Ala Ile Arg Ser Gly Lys Arg Ala Thr Asp Ile 
            340                 345                 350         


Met Pro Asp Met Asp Glu Ser Val Arg Phe His Val Leu Gly Leu Ser 
        355                 360                 365             


Pro Asn Ala Ala Arg Leu Ser Val Arg Phe Trp Glu Val Asp Thr Val 
    370                 375                 380                 


Gly His Met Leu Asp Lys Val Gly Arg His Tyr Arg Glu Leu Glu Ile 
385                 390                 395                 400 


Ile Pro Gln Phe Asn Asn Glu Gln Glu Phe Pro Ser Leu Ser Thr Leu 
                405                 410                 415     


Leu Arg Gln Thr Ala Val Leu Asn Lys Thr Glu Asn Ile Ser Pro Val 
            420                 425                 430         


Leu Ala Gly Gly Leu Phe Arg Ala Met Leu Thr Gly Gly Pro Tyr Pro 
        435                 440                 445             


Gln Ser Leu Leu Pro Ala Val Leu Gly Arg Ile Arg Ala Glu His Ala 
    450                 455                 460                 


Arg Pro Glu Asp Lys Ser Arg Tyr Arg Leu Glu Val Val Thr Tyr Tyr 
465                 470                 475                 480 


Arg Ala Ala Leu Ile Lys Ala Tyr Leu Ile Arg Asn Arg Lys Leu Glu 
                485                 490                 495     


Val Pro Val Ser Leu Asp Pro Ala Arg Thr Asp Arg Pro Tyr Leu Leu 
            500                 505                 510         


Gly Arg Leu Phe Ala Val Leu Glu Lys Ala Gln Glu Asp Ala Val Pro 
        515                 520                 525             


Gly Ala Asn Ala Thr Ile Lys Asp Arg Tyr Leu Ala Ser Ala Ser Ala 
    530                 535                 540                 


Asn Pro Gly Gln Val Phe His Met Leu Leu Lys Asn Ala Ser Asn His 
545                 550                 555                 560 


Thr Ala Lys Leu Arg Lys Asp Pro Glu Arg Lys Gly Ser Ala Ile His 
                565                 570                 575     


Tyr Glu Ile Met Met Gln Glu Ile Ile Asp Asn Ile Ser Asp Phe Pro 
            580                 585                 590         


Val Thr Met Ser Ser Asp Glu Gln Gly Leu Phe Met Ile Gly Tyr Tyr 
        595                 600                 605             


His Gln Arg Lys Ala Leu Phe Thr Lys Lys Asn Lys Glu Asn 
    610                 615                 620         


<210>  22
<211>  135
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLS-(linker 2)-(I-C Cas11c)ںϵ׵İ

<400>  22

Met Pro Lys Lys Lys Arg Lys Val Gly Ser Gly Val Ser Leu Asp Pro 
1               5                   10                  15      


Ala Arg Thr Asp Arg Pro Tyr Leu Leu Gly Arg Leu Phe Ala Val Leu 
            20                  25                  30          


Glu Lys Ala Gln Glu Asp Ala Val Pro Gly Ala Asn Ala Thr Ile Lys 
        35                  40                  45              


Asp Arg Tyr Leu Ala Ser Ala Ser Ala Asn Pro Gly Gln Val Phe His 
    50                  55                  60                  


Met Leu Leu Lys Asn Ala Ser Asn His Thr Ala Lys Leu Arg Lys Asp 
65                  70                  75                  80  


Pro Glu Arg Lys Gly Ser Ala Ile His Tyr Glu Ile Met Met Gln Glu 
                85                  90                  95      


Ile Ile Asp Asn Ile Ser Asp Phe Pro Val Thr Met Ser Ser Asp Glu 
            100                 105                 110         


Gln Gly Leu Phe Met Ile Gly Tyr Tyr His Gln Arg Lys Ala Leu Phe 
        115                 120                 125             


Thr Lys Lys Asn Lys Glu Asn 
    130                 135 


<210>  23
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T2Aĵİ

<400>  23

Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210>  24
<211>  164
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  ʵʩ7I-CϵͳZB7˫RNA

<400>  24
gucgcccccc acgcgggggc guggauugaa acuccuugag cgucuugaug acguugccug       60

cgauacgucg ccccccacgc gggggcgugg auugaaaccu ugagguaagg acugaggauu      120

uuacucaagu uagucgcccc ccacgcgggg gcguggauug aaac                       164


<210>  25
<211>  164
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  ʵʩ7I-CϵͳGA2˫RNA

<400>  25
gucgcccccc acgcgggggc guggauugaa acuuaggaca ccaugagaug ugcgagcugc       60

gagugugucg ccccccacgc gggggcgugg auugaaacuu cgaggacagc cgcuccauca      120

ugcggugcaa cugucgcccc ccacgcgggg gcguggauug aaac                       164


<210>  26
<211>  164
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  I-CϵͳO2λ1O2-1˫е㵼RNAc1/c2

<400>  26
gucgcccccc acgcgggggc guggauugaa acggcaccac caccaccggc ggcggugugc       60

uugucggucg ccccccacgc gggggcgugg auugaaacuc aaggcucaaa caaucacacu      120

ggagguacua uagucgcccc ccacgcgggg gcguggauug aaac                       164


<210>  27
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  c4/c2

<400>  27
ggcaccacca ccaccggcgg cggtgtgctt gtcg                                   34


<210>  28
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  c1

<400>  28
tcaaggctca aacaatcaca ctggaggtac tata                                   34


<210>  29
<211>  164
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  I-CϵͳO2λ2O2-2˫е㵼RNAc3/c4

<400>  29
gucgcccccc acgcgggggc guggauugaa acaagaugcc uaccgaggaa agagugagga       60

aaaggugucg ccccccacgc gggggcgugg auugaaacgg caccaccacc accggcggcg      120

gugugcuugu cggucgcccc ccacgcgggg gcguggauug aaac                       164


<210>  30
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  c3

<400>  30
aagatgccta ccgaggaaag agtgaggaaa aggt                                   34


<210>  31
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  M13F

<400>  31
gtaaaacgac ggccagt                                                      17


<210>  32
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  M13R

<400>  32
caggaaacag ctatgac                                                      17


<210>  33
<211>  1368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cas9׵İ

<400>  33

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  34
<211>  4104
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cas9׵ĺ

<400>  34
atggacaaga agtacagcat cggcctggac atcggcacca actctgtggg ctgggccgtg       60

atcaccgacg agtacaaggt gcccagcaag aaattcaagg tgctgggcaa caccgaccgg      120

cacagcatca agaagaacct gatcggagcc ctgctgttcg acagcggcga aacagccgag      180

gccacccggc tgaagagaac cgccagaaga agatacacca gacggaagaa ccggatctgc      240

tatctgcaag agatcttcag caacgagatg gccaaggtgg acgacagctt cttccacaga      300

ctggaagagt ccttcctggt ggaagaggat aagaagcacg agcggcaccc catcttcggc      360

aacatcgtgg acgaggtggc ctaccacgag aagtacccca ccatctacca cctgagaaag      420

aaactggtgg acagcaccga caaggccgac ctgcggctga tctatctggc cctggcccac      480

atgatcaagt tccggggcca cttcctgatc gagggcgacc tgaaccccga caacagcgac      540

gttgacaagc tgttcatcca gctggtgcag acctacaacc agctgttcga ggaaaacccc      600

atcaacgcca gcggcgtgga cgccaaggcc atcctgtctg ccagactgag caagagcaga      660

cggctggaaa atctgatcgc ccagctgccc ggcgagaaga agaatggcct gttcggaaac      720

ctgattgccc tgagcctggg cctgaccccc aacttcaaga gcaacttcga cctggccgag      780

gatgccaaac tgcagctgag caaggacacc tacgacgacg acctggacaa cctgctggcc      840

cagatcggcg accagtacgc cgacctgttt ctggccgcca agaacctgtc cgacgccatc      900

ctgctgagcg acatcctgag agtgaacacc gagatcacca aggcccccct gagcgcctct      960

atgatcaaga gatacgacga gcaccaccag gacctgaccc tgctgaaagc tctcgtgcgg     1020

cagcagctgc ctgagaagta caaagagatt ttcttcgacc agagcaagaa cggctacgcc     1080

ggctacattg acggcggagc cagccaggaa gagttctaca agttcatcaa gcccatcctg     1140

gaaaagatgg acggcaccga ggaactgctc gtgaagctga acagagagga cctgctgcgg     1200

aagcagcgga ccttcgacaa cggcagcatc ccccaccaga tccacctggg agagctgcac     1260

gccattctgc ggcggcagga agatttttac ccattcctga aggacaaccg ggaaaagatc     1320

gagaagatcc tgaccttccg catcccctac tacgtgggcc ctctggccag gggaaacagc     1380

agattcgcct ggatgaccag aaagagcgag gaaaccatca ccccctggaa cttcgaggaa     1440

gtggtggaca agggcgcttc cgcccagagc ttcatcgagc ggatgaccaa cttcgataag     1500

aacctgccca acgagaaggt gctgcccaag cacagcctgc tgtacgagta cttcaccgtg     1560

tataacgagc tgaccaaagt gaaatacgtg accgagggaa tgagaaagcc cgccttcctg     1620

agcggcgagc agaaaaaggc catcgtggac ctgctgttca agaccaaccg gaaagtgacc     1680

gtgaagcagc tgaaagagga ctacttcaag aaaatcgagt gcttcgactc cgtggaaatc     1740

tccggcgtgg aagatcggtt caacgcctcc ctgggcacat accacgatct gctgaaaatt     1800

atcaaggaca aggacttcct ggacaatgag gaaaacgagg acattctgga agatatcgtg     1860

ctgaccctga cactgtttga ggacagagag atgatcgagg aacggctgaa aacctatgcc     1920

cacctgttcg acgacaaagt gatgaagcag ctgaagcggc ggagatacac cggctggggc     1980

aggctgagcc ggaagctgat caacggcatc cgggacaagc agtccggcaa gacaatcctg     2040

gatttcctga agtccgacgg cttcgccaac agaaacttca tgcagctgat ccacgacgac     2100

agcctgacct ttaaagagga catccagaaa gcccaggtgt ccggccaggg cgatagcctg     2160

cacgagcaca ttgccaatct ggccggcagc cccgccatta agaagggcat cctgcagaca     2220

gtgaaggtgg tggacgagct cgtgaaagtg atgggccggc acaagcccga gaacatcgtg     2280

atcgaaatgg ccagagagaa ccagaccacc cagaagggac agaagaacag ccgcgagaga     2340

atgaagcgga tcgaagaggg catcaaagag ctgggcagcc agatcctgaa agaacacccc     2400

gtggaaaaca cccagctgca gaacgagaag ctgtacctgt actacctgca gaatgggcgg     2460

gatatgtacg tggaccagga actggacatc aaccggctgt ccgactacga tgtggaccat     2520

atcgtgcctc agagctttct gaaggacgac tccatcgaca acaaggtgct gaccagaagc     2580

gacaagaacc ggggcaagag cgacaacgtg ccctccgaag aggtcgtgaa gaagatgaag     2640

aactactggc ggcagctgct gaacgccaag ctgattaccc agagaaagtt cgacaatctg     2700

accaaggccg agagaggcgg cctgagcgaa ctggataagg ccggcttcat caagagacag     2760

ctggtggaaa cccggcagat cacaaagcac gtggcacaga tcctggactc ccggatgaac     2820

actaagtacg acgagaatga caagctgatc cgggaagtga aagtgatcac cctgaagtcc     2880

aagctggtgt ccgatttccg gaaggatttc cagttttaca aagtgcgcga gatcaacaac     2940

taccaccacg cccacgacgc ctacctgaac gccgtcgtgg gaaccgccct gatcaaaaag     3000

taccctaagc tggaaagcga gttcgtgtac ggcgactaca aggtgtacga cgtgcggaag     3060

atgatcgcca agagcgagca ggaaatcggc aaggctaccg ccaagtactt cttctacagc     3120

aacatcatga actttttcaa gaccgagatt accctggcca acggcgagat ccggaagcgg     3180

cctctgatcg agacaaacgg cgaaaccggg gagatcgtgt gggataaggg ccgggatttt     3240

gccaccgtgc ggaaagtgct gagcatgccc caagtgaata tcgtgaaaaa gaccgaggtg     3300

cagacaggcg gcttcagcaa agagtctatc ctgcccaaga ggaacagcga taagctgatc     3360

gccagaaaga aggactggga ccctaagaag tacggcggct tcgacagccc caccgtggcc     3420

tattctgtgc tggtggtggc caaagtggaa aagggcaagt ccaagaaact gaagagtgtg     3480

aaagagctgc tggggatcac catcatggaa agaagcagct tcgagaagaa tcccatcgac     3540

tttctggaag ccaagggcta caaagaagtg aaaaaggacc tgatcatcaa gctgcctaag     3600

tactccctgt tcgagctgga aaacggccgg aagagaatgc tggcctctgc cggcgaactg     3660

cagaagggaa acgaactggc cctgccctcc aaatatgtga acttcctgta cctggccagc     3720

cactatgaga agctgaaggg ctcccccgag gataatgagc agaaacagct gtttgtggaa     3780

cagcacaagc actacctgga cgagatcatc gagcagatca gcgagttctc caagagagtg     3840

atcctggccg acgctaatct ggacaaagtg ctgtccgcct acaacaagca ccgggataag     3900

cccatcagag agcaggccga gaatatcatc cacctgttta ccctgaccaa tctgggagcc     3960

cctgccgcct tcaagtactt tgacaccacc atcgaccgga agaggtacac cagcaccaaa     4020

gaggtgctgg acgccaccct gatccaccag agcatcaccg gcctgtacga gacacggatc     4080

gacctgtctc agctgggagg cgac                                            4104


<210>  35
<211>  888
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I-E Cas3׵İ

<400>  35

Met Glu Pro Phe Lys Tyr Ile Cys His Tyr Trp Gly Lys Ser Ser Lys 
1               5                   10                  15      


Ser Leu Thr Lys Gly Asn Asp Ile His Leu Leu Ile Tyr His Cys Leu 
            20                  25                  30          


Asp Val Ala Ala Val Ala Asp Cys Trp Trp Asp Gln Ser Val Val Leu 
        35                  40                  45              


Gln Asn Thr Phe Cys Arg Asn Glu Met Leu Ser Lys Gln Arg Val Lys 
    50                  55                  60                  


Ala Trp Leu Leu Phe Phe Ile Ala Leu His Asp Ile Gly Lys Phe Asp 
65                  70                  75                  80  


Ile Arg Phe Gln Tyr Lys Ser Ala Glu Ser Trp Leu Lys Leu Asn Pro 
                85                  90                  95      


Ala Thr Pro Ser Leu Asn Gly Pro Ser Thr Gln Met Cys Arg Lys Phe 
            100                 105                 110         


Asn His Gly Ala Ala Gly Leu Tyr Trp Phe Asn Gln Asp Ser Leu Ser 
        115                 120                 125             


Glu Gln Ser Leu Gly Asp Phe Phe Ser Phe Phe Asp Ala Ala Pro His 
    130                 135                 140                 


Pro Tyr Glu Ser Trp Phe Pro Trp Val Glu Ala Val Thr Gly His His 
145                 150                 155                 160 


Gly Phe Ile Leu His Ser Gln Asp Gln Asp Lys Ser Arg Trp Glu Met 
                165                 170                 175     


Pro Ala Ser Leu Ala Ser Tyr Ala Ala Gln Asp Lys Gln Ala Arg Glu 
            180                 185                 190         


Glu Trp Ile Ser Val Leu Glu Ala Leu Phe Leu Thr Pro Ala Gly Leu 
        195                 200                 205             


Ser Ile Asn Asp Ile Pro Pro Asp Cys Ser Ser Leu Leu Ala Gly Phe 
    210                 215                 220                 


Cys Ser Leu Ala Asp Trp Leu Gly Ser Trp Thr Thr Thr Asn Thr Phe 
225                 230                 235                 240 


Leu Phe Asn Glu Asp Ala Pro Ser Asp Ile Asn Ala Leu Arg Thr Tyr 
                245                 250                 255     


Phe Gln Asp Arg Gln Gln Asp Ala Ser Arg Val Leu Glu Leu Ser Gly 
            260                 265                 270         


Leu Val Ser Asn Lys Arg Cys Tyr Glu Gly Val His Ala Leu Leu Asp 
        275                 280                 285             


Asn Gly Tyr Gln Pro Arg Gln Leu Gln Val Leu Val Asp Ala Leu Pro 
    290                 295                 300                 


Val Ala Pro Gly Leu Thr Val Ile Glu Ala Pro Thr Gly Ser Gly Lys 
305                 310                 315                 320 


Thr Glu Thr Ala Leu Ala Tyr Ala Trp Lys Leu Ile Asp Gln Gln Ile 
                325                 330                 335     


Ala Asp Ser Val Ile Phe Ala Leu Pro Thr Gln Ala Thr Ala Asn Ala 
            340                 345                 350         


Met Leu Thr Arg Met Glu Ala Ser Ala Ser His Leu Phe Ser Ser Pro 
        355                 360                 365             


Asn Leu Ile Leu Ala His Gly Asn Ser Arg Phe Asn His Leu Phe Gln 
    370                 375                 380                 


Ser Ile Lys Ser Arg Ala Ile Thr Glu Gln Gly Gln Glu Glu Ala Trp 
385                 390                 395                 400 


Val Gln Cys Cys Gln Trp Leu Ser Gln Ser Asn Lys Lys Val Phe Leu 
                405                 410                 415     


Gly Gln Ile Gly Val Cys Thr Ile Asp Gln Val Leu Ile Ser Val Leu 
            420                 425                 430         


Pro Val Lys His Arg Phe Ile Arg Gly Leu Gly Ile Gly Arg Ser Val 
        435                 440                 445             


Leu Ile Val Asp Glu Val His Ala Tyr Asp Thr Tyr Met Asn Gly Leu 
    450                 455                 460                 


Leu Glu Ala Val Leu Lys Ala Gln Ala Asp Val Gly Gly Ser Val Ile 
465                 470                 475                 480 


Leu Leu Ser Ala Thr Leu Pro Met Lys Gln Lys Gln Lys Leu Leu Asp 
                485                 490                 495     


Thr Tyr Gly Leu His Thr Asp Pro Val Glu Asn Asn Ser Ala Tyr Pro 
            500                 505                 510         


Leu Ile Asn Trp Arg Gly Val Asn Gly Ala Gln Arg Phe Asp Leu Leu 
        515                 520                 525             


Ala His Pro Glu Gln Leu Pro Pro Arg Phe Ser Ile Gln Pro Glu Pro 
    530                 535                 540                 


Ile Cys Leu Ala Asp Met Leu Pro Asp Leu Thr Met Leu Glu Arg Met 
545                 550                 555                 560 


Ile Ala Ala Ala Asn Ala Gly Ala Gln Val Cys Leu Ile Cys Asn Leu 
                565                 570                 575     


Val Asp Val Ala Gln Val Cys Tyr Gln Arg Leu Lys Glu Leu Asn Asn 
            580                 585                 590         


Thr Gln Val Asp Ile Asp Leu Phe His Ala Arg Phe Thr Leu Asn Asp 
        595                 600                 605             


Arg Arg Glu Lys Glu Asn Arg Val Ile Ser Asn Phe Gly Lys Asn Gly 
    610                 615                 620                 


Lys Arg Asn Val Gly Arg Ile Leu Val Ala Thr Gln Val Val Glu Gln 
625                 630                 635                 640 


Ser Leu Asp Val Asp Phe Asp Trp Leu Ile Thr Gln His Cys Pro Ala 
                645                 650                 655     


Asp Leu Leu Phe Gln Arg Leu Gly Arg Leu His Arg His His Arg Lys 
            660                 665                 670         


Tyr Arg Pro Ala Gly Phe Glu Ile Pro Val Ala Thr Ile Leu Leu Pro 
        675                 680                 685             


Asp Gly Glu Gly Tyr Gly Arg His Glu His Ile Tyr Ser Asn Val Arg 
    690                 695                 700                 


Val Met Trp Arg Thr Gln Gln His Ile Glu Glu Leu Asn Gly Ala Ser 
705                 710                 715                 720 


Leu Phe Phe Pro Asp Ala Tyr Arg Gln Trp Leu Asp Ser Ile Tyr Asp 
                725                 730                 735     


Asp Ala Glu Met Asp Glu Pro Glu Trp Val Gly Asn Gly Met Asp Lys 
            740                 745                 750         


Phe Glu Ser Ala Glu Cys Glu Lys Arg Phe Lys Ala Arg Lys Val Leu 
        755                 760                 765             


Gln Trp Ala Glu Glu Tyr Ser Leu Gln Asp Asn Asp Glu Thr Ile Leu 
    770                 775                 780                 


Ala Val Thr Arg Asp Gly Glu Met Ser Leu Pro Leu Leu Pro Tyr Val 
785                 790                 795                 800 


Gln Thr Ser Ser Gly Lys Gln Leu Leu Asp Gly Gln Val Tyr Glu Asp 
                805                 810                 815     


Leu Ser His Glu Gln Gln Tyr Glu Ala Leu Ala Leu Asn Arg Val Asn 
            820                 825                 830         


Val Pro Phe Thr Trp Lys Arg Ser Phe Ser Glu Val Val Asp Glu Asp 
        835                 840                 845             


Gly Leu Leu Trp Leu Glu Gly Lys Gln Asn Leu Asp Gly Trp Val Trp 
    850                 855                 860                 


Gln Gly Asn Ser Ile Val Ile Thr Tyr Thr Gly Asp Glu Gly Met Thr 
865                 870                 875                 880 


Arg Val Ile Pro Ala Asn Pro Lys 
                885             


<210>  36
<211>  363
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I-E Cas7׵İ

<400>  36

Met Ser Asn Phe Ile Asn Ile His Val Leu Ile Ser His Ser Pro Ser 
1               5                   10                  15      


Cys Leu Asn Arg Asp Asp Met Asn Met Gln Lys Asp Ala Ile Phe Gly 
            20                  25                  30          


Gly Lys Arg Arg Val Arg Ile Ser Ser Gln Ser Leu Lys Arg Ala Met 
        35                  40                  45              


Arg Lys Ser Gly Tyr Tyr Ala Gln Asn Ile Gly Glu Ser Ser Leu Arg 
    50                  55                  60                  


Thr Ile His Leu Ala Gln Leu Arg Asp Val Leu Arg Gln Lys Leu Gly 
65                  70                  75                  80  


Glu Arg Phe Asp Gln Lys Ile Ile Asp Lys Thr Leu Ala Leu Leu Ser 
                85                  90                  95      


Gly Lys Ser Val Asp Glu Ala Glu Lys Ile Ser Ala Asp Ala Val Thr 
            100                 105                 110         


Pro Trp Val Val Gly Glu Ile Ala Trp Phe Cys Glu Gln Val Ala Lys 
        115                 120                 125             


Ala Glu Ala Asp Asn Leu Asp Asp Lys Lys Leu Leu Lys Val Leu Lys 
    130                 135                 140                 


Glu Asp Ile Ala Ala Ile Arg Val Asn Leu Gln Gln Gly Val Asp Ile 
145                 150                 155                 160 


Ala Leu Ser Gly Arg Met Ala Thr Ser Gly Met Met Thr Glu Leu Gly 
                165                 170                 175     


Lys Val Asp Gly Ala Met Ser Ile Ala His Ala Ile Thr Thr His Gln 
            180                 185                 190         


Val Asp Ser Asp Ile Asp Trp Phe Thr Ala Val Asp Asp Leu Gln Glu 
        195                 200                 205             


Gln Gly Ser Ala His Leu Gly Thr Gln Glu Phe Ser Ser Gly Val Phe 
    210                 215                 220                 


Tyr Arg Tyr Ala Asn Ile Asn Leu Ala Gln Leu Gln Glu Asn Leu Gly 
225                 230                 235                 240 


Gly Ala Ser Arg Glu Gln Ala Leu Glu Ile Ala Thr His Val Val His 
                245                 250                 255     


Met Leu Ala Thr Glu Val Pro Gly Ala Lys Gln Arg Thr Tyr Ala Ala 
            260                 265                 270         


Phe Asn Pro Ala Asp Met Val Met Val Asn Phe Ser Asp Met Pro Leu 
        275                 280                 285             


Ser Met Ala Asn Ala Phe Glu Lys Ala Val Lys Ala Lys Asp Gly Phe 
    290                 295                 300                 


Leu Gln Pro Ser Ile Gln Ala Phe Asn Gln Tyr Trp Asp Arg Val Ala 
305                 310                 315                 320 


Asn Gly Tyr Gly Leu Asn Gly Ala Ala Ala Gln Phe Ser Leu Ser Asp 
                325                 330                 335     


Val Asp Pro Ile Thr Ala Gln Val Lys Gln Met Pro Thr Leu Glu Gln 
            340                 345                 350         


Leu Lys Ser Trp Val Arg Asn Asn Gly Glu Ala 
        355                 360             


<210>  37
<211>  160
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I-E Cse2׵İ

<400>  37

Met Ala Asp Glu Ile Asp Ala Met Ala Leu Tyr Arg Ala Trp Gln Gln 
1               5                   10                  15      


Leu Asp Asn Gly Ser Cys Ala Gln Ile Arg Arg Val Ser Glu Pro Asp 
            20                  25                  30          


Glu Leu Arg Asp Ile Pro Ala Phe Tyr Arg Leu Val Gln Pro Phe Gly 
        35                  40                  45              


Trp Glu Asn Pro Arg His Gln Gln Ala Leu Leu Arg Met Val Phe Cys 
    50                  55                  60                  


Leu Ser Ala Gly Lys Asn Val Ile Arg His Gln Asp Lys Lys Ser Glu 
65                  70                  75                  80  


Gln Thr Thr Gly Ile Ser Leu Gly Arg Ala Leu Ala Asn Ser Gly Arg 
                85                  90                  95      


Ile Asn Glu Arg Arg Ile Phe Gln Leu Ile Arg Ala Asp Arg Thr Ala 
            100                 105                 110         


Asp Met Val Gln Leu Arg Arg Leu Leu Thr His Ala Glu Pro Val Leu 
        115                 120                 125             


Asp Trp Pro Leu Met Ala Arg Met Leu Thr Trp Trp Gly Lys Arg Glu 
    130                 135                 140                 


Arg Gln Gln Leu Leu Glu Asp Phe Val Leu Thr Thr Asn Lys Asn Ala 
145                 150                 155                 160 


<210>  38
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I-E Cas5׵İ

<400>  38

Met Arg Ser Tyr Leu Ile Leu Arg Leu Ala Gly Pro Met Gln Ala Trp 
1               5                   10                  15      


Gly Gln Pro Thr Phe Glu Gly Thr Arg Pro Thr Gly Arg Phe Pro Thr 
            20                  25                  30          


Arg Ser Gly Leu Leu Gly Leu Leu Gly Ala Cys Leu Gly Ile Gln Arg 
        35                  40                  45              


Asp Asp Thr Ser Ser Leu Gln Ala Leu Ser Glu Ser Val Gln Phe Ala 
    50                  55                  60                  


Val Arg Cys Asp Glu Leu Ile Leu Asp Asp Arg Arg Val Ser Val Thr 
65                  70                  75                  80  


Gly Leu Arg Asp Tyr His Thr Val Leu Gly Ala Arg Glu Asp Tyr Arg 
                85                  90                  95      


Gly Leu Lys Ser His Glu Thr Ile Gln Thr Trp Arg Glu Tyr Leu Cys 
            100                 105                 110         


Asp Ala Ser Phe Thr Val Ala Leu Trp Leu Thr Pro His Ala Thr Met 
        115                 120                 125             


Val Ile Ser Glu Leu Glu Lys Ala Val Leu Lys Pro Arg Tyr Thr Pro 
    130                 135                 140                 


Tyr Leu Gly Arg Arg Ser Cys Pro Leu Thr His Pro Leu Phe Leu Gly 
145                 150                 155                 160 


Thr Cys Gln Ala Ser Asp Pro Gln Lys Ala Leu Leu Asn Tyr Glu Pro 
                165                 170                 175     


Val Gly Gly Asp Ile Tyr Ser Glu Glu Ser Val Thr Gly His His Leu 
            180                 185                 190         


Lys Phe Thr Ala Arg Asp Glu Pro Met Ile Thr Leu Pro Arg Gln Phe 
        195                 200                 205             


Ala Ser Arg Glu Trp Tyr Val Ile Lys Gly Gly Met Asp Val Ser Gln 
    210                 215                 220                 


<210>  39
<211>  199
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I-E Cas6׵İ

<400>  39

Met Tyr Leu Ser Lys Val Ile Ile Ala Arg Ala Trp Ser Arg Asp Leu 
1               5                   10                  15      


Tyr Gln Leu His Gln Gly Leu Trp His Leu Phe Pro Asn Arg Pro Asp 
            20                  25                  30          


Ala Ala Arg Asp Phe Leu Phe His Val Glu Lys Arg Asn Thr Pro Glu 
        35                  40                  45              


Gly Cys His Val Leu Leu Gln Ser Ala Gln Met Pro Val Ser Thr Ala 
    50                  55                  60                  


Val Ala Thr Val Ile Lys Thr Lys Gln Val Glu Phe Gln Leu Gln Val 
65                  70                  75                  80  


Gly Val Pro Leu Tyr Phe Arg Leu Arg Ala Asn Pro Ile Lys Thr Ile 
                85                  90                  95      


Leu Asp Asn Gln Lys Arg Leu Asp Ser Lys Gly Asn Ile Lys Arg Cys 
            100                 105                 110         


Arg Val Pro Leu Ile Lys Glu Ala Glu Gln Ile Ala Trp Leu Gln Arg 
        115                 120                 125             


Lys Leu Gly Asn Ala Ala Arg Val Glu Asp Val His Pro Ile Ser Glu 
    130                 135                 140                 


Arg Pro Gln Tyr Phe Ser Gly Asp Gly Lys Ser Gly Lys Ile Gln Thr 
145                 150                 155                 160 


Val Cys Phe Glu Gly Val Leu Thr Ile Asn Asp Ala Pro Ala Leu Ile 
                165                 170                 175     


Asp Leu Val Gln Gln Gly Ile Gly Pro Ala Lys Ser Met Gly Cys Gly 
            180                 185                 190         


Leu Leu Ser Leu Ala Pro Leu 
        195                 


<210>  40
<211>  502
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I-E Cse1׵İ

<400>  40

Met Asn Leu Leu Ile Asp Asn Trp Ile Pro Val Arg Pro Arg Asn Gly 
1               5                   10                  15      


Gly Lys Val Gln Ile Ile Asn Leu Gln Ser Leu Tyr Cys Ser Arg Asp 
            20                  25                  30          


Gln Trp Arg Leu Ser Leu Pro Arg Asp Asp Met Glu Leu Ala Ala Leu 
        35                  40                  45              


Ala Leu Leu Val Cys Ile Gly Gln Ile Ile Ala Pro Ala Lys Asp Asp 
    50                  55                  60                  


Val Glu Phe Arg His Arg Ile Met Asn Pro Leu Thr Glu Asp Glu Phe 
65                  70                  75                  80  


Gln Gln Leu Ile Ala Pro Trp Ile Asp Met Phe Tyr Leu Asn His Ala 
                85                  90                  95      


Glu His Pro Phe Met Gln Thr Lys Gly Val Lys Ala Asn Asp Val Thr 
            100                 105                 110         


Pro Met Glu Lys Leu Leu Ala Gly Val Ser Gly Ala Thr Asn Cys Ala 
        115                 120                 125             


Phe Val Asn Gln Pro Gly Gln Gly Glu Ala Leu Cys Gly Gly Cys Thr 
    130                 135                 140                 


Ala Ile Ala Leu Phe Asn Gln Ala Asn Gln Ala Pro Gly Phe Gly Gly 
145                 150                 155                 160 


Gly Phe Lys Ser Gly Leu Arg Gly Gly Thr Pro Val Thr Thr Phe Val 
                165                 170                 175     


Arg Gly Ile Asp Leu Arg Ser Thr Val Leu Leu Asn Val Leu Thr Leu 
            180                 185                 190         


Pro Arg Leu Gln Lys Gln Phe Pro Asn Glu Ser His Thr Glu Asn Gln 
        195                 200                 205             


Pro Thr Trp Ile Lys Pro Ile Lys Ser Asn Glu Ser Ile Pro Ala Ser 
    210                 215                 220                 


Ser Ile Gly Phe Val Arg Gly Leu Phe Trp Gln Pro Ala His Ile Glu 
225                 230                 235                 240 


Leu Cys Asp Pro Ile Gly Ile Gly Lys Cys Ser Cys Cys Gly Gln Glu 
                245                 250                 255     


Ser Asn Leu Arg Tyr Thr Gly Phe Leu Lys Glu Lys Phe Thr Phe Thr 
            260                 265                 270         


Val Asn Gly Leu Trp Pro His Pro His Ser Pro Cys Leu Val Thr Val 
        275                 280                 285             


Lys Lys Gly Glu Val Glu Glu Lys Phe Leu Ala Phe Thr Thr Ser Ala 
    290                 295                 300                 


Pro Ser Trp Thr Gln Ile Ser Arg Val Val Val Asp Lys Ile Ile Gln 
305                 310                 315                 320 


Asn Glu Asn Gly Asn Arg Val Ala Ala Val Val Asn Gln Phe Arg Asn 
                325                 330                 335     


Ile Ala Pro Gln Ser Pro Leu Glu Leu Ile Met Gly Gly Tyr Arg Asn 
            340                 345                 350         


Asn Gln Ala Ser Ile Leu Glu Arg Arg His Asp Val Leu Met Phe Asn 
        355                 360                 365             


Gln Gly Trp Gln Gln Tyr Gly Asn Val Ile Asn Glu Ile Val Thr Val 
    370                 375                 380                 


Gly Leu Gly Tyr Lys Thr Ala Leu Arg Lys Ala Leu Tyr Thr Phe Ala 
385                 390                 395                 400 


Glu Gly Phe Lys Asn Lys Asp Phe Lys Gly Ala Gly Val Ser Val His 
                405                 410                 415     


Glu Thr Ala Glu Arg His Phe Tyr Arg Gln Ser Glu Leu Leu Ile Pro 
            420                 425                 430         


Asp Val Leu Ala Asn Val Asn Phe Ser Gln Ala Asp Glu Val Ile Ala 
        435                 440                 445             


Asp Leu Arg Asp Lys Leu His Gln Leu Cys Glu Met Leu Phe Asn Gln 
    450                 455                 460                 


Ser Val Ala Pro Tyr Ala His His Pro Lys Leu Ile Ser Thr Leu Ala 
465                 470                 475                 480 


Leu Ala Arg Ala Thr Leu Tyr Lys His Leu Arg Glu Leu Lys Pro Gln 
                485                 490                 495     


Gly Gly Pro Ser Asn Gly 
            500         


<210>  41
<211>  2664
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  I-E Cas3׵ĺ

<400>  41
atggagccct ttaagtacat ctgccattat tggggcaaat catcaaaaag tttgaccaag       60

ggtaatgaca tccacctcct gatatatcat tgtctggatg ttgcagccgt cgccgattgc      120

tggtgggacc aatcagtggt gctgcaaaat acattttgcc gcaatgagat gcttagcaag      180

caaagagtca aagcctggtt gctattcttt attgctcttc atgatattgg taaattcgat      240

attcgctttc agtacaagag cgctgagagc tggctgaagt taaaccctgc cacgccttcc      300

ctaaatgggc cgtctacaca gatgtgcaga aaattcaacc acggcgcggc tggtctctac      360

tggtttaatc aagacagcct gagtgaacag tccctaggcg acttcttcag cttcttcgac      420

gcggcgccgc acccatatga atcctggttc ccgtgggtag aggcagtgac cggccaccat      480

ggtttcattc tgcatagcca ggatcaggat aagtcaagat gggagatgcc ggccagtctc      540

gcgtcatacg ccgcccaaga caagcaggcg cgggaggaat ggatctctgt tctggaggcc      600

ctattcctga cgccggcggg gttgtccata aatgatatac cacccgactg ctcttctcta      660

ctcgctggat tttgttcgct tgcggattgg ttaggttcgt ggaccacgac taacacattc      720

ctgttcaatg aagatgctcc ttccgacatc aatgcactgc ggacttattt ccaggatcgc      780

cagcaggacg cgtcgcgggt cctggagctc tcgggtctgg tcagcaacaa gcgctgctac      840

gagggtgttc atgcgttact cgacaacggc taccagccta ggcagctcca ggttttggta      900

gacgccctcc cagtagcccc aggcttaact gttattgaag cgccaactgg atcaggaaaa      960

actgagacag cacttgctta tgcatggaaa ttgattgatc aacagattgc ggacagcgta     1020

atatttgctc taccgacgca ggccaccgcc aatgccatgc tgactaggat ggaagctagt     1080

gctagtcatc tgttctcatc tccaaacttg atcctggcgc acggaaactc taggttcaac     1140

catcttttcc agagtataaa gtctagggca atcacagaac aaggccagga ggaagcgtgg     1200

gtgcagtgct gccagtggct ctctcagagc aataaaaagg tgttcctcgg ccaaattggc     1260

gtctgtacca tcgatcaggt gctcatatca gttctgccag tgaagcaccg cttcatccgc     1320

ggcttgggca taggccgttc ggtgcttatt gttgacgagg tgcatgcata tgacacatac     1380

atgaatggac tgctcgaggc ggtgcttaaa gctcaagctg acgtcggggg gtccgtcatc     1440

ctgctttctg ctactctgcc catgaagcaa aaacagaagt tgctggacac ctacggcttg     1500

cacactgatc ccgttgaaaa taactccgct tacccgttga tcaactggcg tggcgtgaat     1560

ggtgctcagc ggtttgatct tctggctcat ccagagcagc tacctccgcg attttcaatc     1620

cagccggaac caatctgtct cgccgacatg ttacccgacc tgaccatgtt ggagagaatg     1680

atcgcggcag caaatgctgg ggcgcaggta tgcctcatct gcaacctcgt ggatgtggcc     1740

caagtgtgtt atcaacggct caaggaactt aacaacacgc aggttgatat cgatttgttc     1800

cacgcccgct tcaccctgaa cgaccggaga gagaaggaga accgtgtcat atcgaacttc     1860

ggcaagaatg ggaagaggaa cgtgggaagg attcttgtcg caacacaagt tgtcgagcaa     1920

tccttagatg tggactttga ctggctcatc acccagcact gtccggccga cctcctcttc     1980

cagaggttgg ggaggctcca tcgccaccac aggaagtata gaccagccgg gtttgagata     2040

cccgtcgcta ccatccttct tcctgatgga gaaggatacg ggcgtcacga gcacatctac     2100

tcaaatgtgc gcgtcatgtg gcgcacccag caacatattg aagagctcaa cggagcctcg     2160

cttttttttc cggacgccta ccggcaatgg ttagattcta tttatgatga cgcagaaatg     2220

gacgagcctg agtgggtggg caacggcatg gacaagtttg aatctgcgga gtgcgagaaa     2280

cgtttcaagg ctaggaaagt tctccagtgg gcggaagagt acagtttgca agacaatgat     2340

gaaactattc tcgccgtaac gagagatggt gaaatgtctc tccctttact accttatgtt     2400

cagacttcct ctggaaaaca acttctcgat ggccaagtct acgaagatct gagccatgag     2460

cagcaatatg aagcccttgc actgaatcga gtcaacgttc ctttcacatg gaagagaagt     2520

ttttcggagg ttgttgatga ggacggcctt ctctggcttg aagggaagca gaacctggat     2580

gggtgggtct ggcagggaaa tagcatagtc attacgtaca cgggagatga ggggatgaca     2640

cgggtgatcc cggctaatcc aaag                                            2664


<210>  42
<211>  1089
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  I-E Cas7׵ĺ

<400>  42
atgagcaact tcatcaacat ccacgtgctc atctcgcaca gcccctcctg cctgaacagg       60

gacgacatga acatgcagaa ggacgccatc ttcggcggca agcgcagggt caggatctcc      120

agccagagcc tcaagcgcgc catgaggaag tccggctact acgcgcagaa catcggcgag      180

tccagcctga ggacgatcca cctcgctcag ctgagggacg tgctcaggca gaagctgggc      240

gagaggttcg accagaagat catcgacaag acgctggctc tcctgtcggg caagtccgtg      300

gacgaggcgg agaagatcag cgccgacgcg gtgaccccat gggtggtggg cgagatcgct      360

tggttctgcg agcaggtggc caaggcggag gccgacaacc tcgacgacaa gaagctcctg      420

aaggtcctga aggaggacat cgcggccatc agggtgaacc tccagcaggg cgtggacatc      480

gctctgtcgg gcaggatggc cacctccggc atgatgacgg agctgggcaa ggtggacggc      540

gctatgagca tcgctcacgc gatcaccacg caccaggtgg actccgacat cgactggttc      600

accgccgtcg acgacctcca ggagcagggc agcgcccacc tgggcacgca ggagttctcc      660

agcggcgtgt tctaccgcta cgccaacatc aacctcgccc agctgcagga gaacctcggc      720

ggcgcctcgc gcgagcaggc cctggagatc gccacccacg tggtgcacat gctggctacc      780

gaggtcccgg gcgccaagca gaggacgtac gctgcgttca accccgcgga catggtcatg      840

gtcaacttca gcgacatgcc gctctccatg gccaacgcgt tcgagaaggc ggtgaaggcg      900

aaggacggct tcctgcagcc gagcatccag gccttcaacc agtactggga cagggtggcc      960

aacggctacg ggctcaacgg cgcggccgct cagttcagcc tctcggacgt ggacccgatc     1020

acggctcagg tcaagcagat gcccacgctc gagcagctga agtcctgggt gaggaacaac     1080

ggcgaggcg                                                             1089


<210>  43
<211>  480
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  I-E Cse2׵ĺ

<400>  43
atggcagatg agattgacgc catggctttg tacagggcat ggcagcagct agataatggc       60

agctgtgcgc agataaggag ggtgtcagag ccggatgagc tcagggatat acccgcgttc      120

tacagactgg tccagccatt tggctgggag aatccacggc atcagcaggc gctgctccgg      180

atggtcttct gcttatctgc tgggaagaac gtcatcaggc atcaggacaa gaaatctgag      240

cagacaacag ggatctcgct tggcagagcc cttgctaact cggggcgtat taatgaacgc      300

cgcatcttcc agctgattcg ggccgaccgg actgcggaca tggtgcaatt acgacgcttg      360

cttacacatg ctgaacctgt gctcgactgg ccactcatgg cgaggatgct gacatggtgg      420

ggcaaacgag aacggcaaca actgctggag gactttgtac tgaccaccaa caagaatgcg      480


<210>  44
<211>  672
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  I-E Cas5׵ĺ

<400>  44
atgaggtcct acctcatcct gaggctcgcc ggccccatgc aggcgtgggg ccagcccacc       60

ttcgagggca ccaggccgac cggccgcttc ccaacccgca gcggcctcct cgggctcctc      120

ggcgcctgcc tgggcatcca gagggacgac acctccagcc tgcaggccct ctcggagtcg      180

gtgcagttcg cggtcaggtg cgacgagctg atcctcgacg acaggagggt gtccgtcacg      240

ggcctgaggg actaccacac cgtgctgggc gccagggagg actacagggg cctgaagtcc      300

cacgagacca tccagacgtg gagggagtac ctctgcgacg ccagcttcac cgtggccctg      360

tggctcaccc cgcacgcgac catggtcatc agcgagctgg agaaggcggt cctcaagccc      420

aggtacaccc cgtacctggg caggaggtcc tgccccctca cgcacccgct gttcctcggc      480

acgtgccagg ccagcgaccc gcagaaggcg ctcctgaact acgagccggt gggcggcgac      540

atctactccg aggagagcgt caccggccac cacctgaagt tcacggccag ggacgagccg      600

atgatcacgc tcccaaggca gttcgcctcc agggagtggt atgtgatcaa gggcggcatg      660

gacgtcagcc ag                                                          672


<210>  45
<211>  597
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  I-E Cas6׵ĺ

<400>  45
atgtacttgt ccaaagtgat tattgccagg gcctggagcc gtgaccttta tcaacttcac       60

caggggctct ggcacctctt tccaaacagg cctgatgctg ccagggactt cctcttccac      120

gtcgagaaaa gaaatactcc ggaaggctgc catgtgcttc tccaatcagc acagatgcct      180

gtatccaccg ctgttgctac ggttataaag accaagcagg ttgagtttca attgcaggtc      240

ggcgtgccgt tgtatttccg tcttcgcgcc aaccctatca agactatact cgacaaccag      300

aagcgcctcg attcaaaggg caacatcaaa agatgcaggg tgccgttaat caaggaagca      360

gaacaaatag cttggctgca aagaaaactg ggaaatgcag cgcgagttga agatgtccac      420

cctatttcag agagaccgca gtacttctct ggtgatggaa aaagcgggaa gatccagacg      480

gtgtgctttg agggcgtcct aacgatcaat gatgcacccg ccttgattga tctggtgcag      540

caaggtattg gccccgccaa gagcatggga tgtggactgt taagccttgc cccgttg         597


<210>  46
<211>  1509
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  I-E Cse1׵ĺ

<400>  46
atgaacctcc tgatcgacaa ctggattccg gtgcgcccaa ggaacggcgg caaggtgcag       60

atcatcaacc tccagtccct gtactgctcc agggaccagt ggaggctcag cctgccgcgg      120

gacgacatgg agctggccgc cctcgccctc ctggtctgca tcggccagat catcgctccg      180

gccaaggacg acgtggagtt ccgccacagg atcatgaacc cgctcaccga ggacgagttc      240

cagcagctga tcgcgccctg gatcgacatg ttctacctca accacgccga gcacccgttc      300

atgcagacca agggcgtcaa ggcgaacgac gtgacgccca tggagaagct cctggcgggc      360

gtctccggcg ccaccaactg cgccttcgtg aaccagcccg gccagggcga ggccctctgc      420

ggtggctgca cggccatcgc gctgttcaac caggcgaacc aggcccccgg cttcggcggc      480

ggcttcaagt ccgggctccg cggcggcacc ccggtcacca ccttcgtgcg cggcatcgac      540

ctcaggagca ccgtcctcct gaacgtgctc acgctgccga ggctgcagaa gcagttcccc      600

aacgagagcc acaccgagaa ccagccgacg tggatcaagc ccatcaagtc caacgagagc      660

atccccgcct ccagcatcgg cttcgtccgc ggcctcttct ggcagcccgc tcacatcgag      720

ctgtgcgacc ccatcggcat cggcaagtgc tcctgctgcg gccaggagag caacctcagg      780

tacacgggct tcctgaagga gaagttcacc ttcacggtca acggcctctg gccccaccca      840

cactccccct gcctggtcac cgtgaagaag ggcgaggtgg aggagaagtt cctggcgttc      900

accacgtccg ctccaagctg gacccagatc agcagggtgg tcgtggacaa gatcatccag      960

aacgagaacg gcaacagggt ggcggccgtg gtgaaccagt tcaggaacat cgcgccgcag     1020

tccccgctcg agctgatcat gggcggctac aggaacaacc aggccagcat cctcgagcgc     1080

aggcacgacg tcctgatgtt caaccagggc tggcagcagt acggcaacgt gatcaacgag     1140

atcgtcacgg tgggcctggg ctacaagacc gccctccgca aggccctgta caccttcgcg     1200

gagggcttca agaacaagga cttcaagggc gccggcgtct ccgtgcacga gaccgccgag     1260

cgccacttct acaggcagag cgagctcctg atcccggacg tcctggccaa cgtgaacttc     1320

tcgcaggccg acgaggtcat cgccgacctc cgcgacaagc tccaccagct gtgcgagatg     1380

ctgttcaacc agtcggtggc cccctacgct caccacccca agctcatcag caccctcgct     1440

ctggccaggg ctaccctgta caagcacctc agggagctga agccccaggg cggcccaagc     1500

aacggctaa                                                             1509


<210>  47
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  I-Eϵͳĳͬظ-ṹĵһ

<400>  47
gugagcccca cgcacguggg g                                                 21


<210>  48
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  I-Eϵͳͬظ-ṹĵڶ

<400>  48
auggaccg                                                                 8


<210>  49
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  ʵʩ2I-CϵͳYFFPĵRNA1IC-1

<400>  49
gucgcccccc acgcgggggc guggauugaa accuuauaua gaggaagggu cuugcgaagg       60

auaguggucg ccccccacgc gggggcgugg auugaaac                               98


<210>  50
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  ʵʩ2I-CϵͳYFFPĵRNA2IC-2

<400>  50
gucgcccccc acgcgggggc guggauugaa acgagggcga cacccuggug aaccgcaucg       60

agcugagucg ccccccacgc gggggcgugg auugaaac                               98


<210>  51
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  ʵʩ2I-CϵͳYFFPĵRNA3IC-3

<400>  51
gucgcccccc acgcgggggc guggauugaa acccuuuauc ucuuagggau aacaggguaa       60

uagagagucg ccccccacgc gggggcgugg auugaaac                               98


<210>  52
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  ʵʩ3I-Cϵͳ˫ӫøϵͳĵRNA

<400>  52
gucgcccccc acgcgggggc guggauugaa acauucucgg cggccgccag ggcgucggcc       60

ucggucgucg ccccccacgc gggggcgugg auugaaac                               98


<210>  53
<211>  92
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  ʵʩ3I-Eϵͳ˫ӫøϵͳĵRNA

<400>  53
gugagcccca cgcacguggg gauggaccgg caccgcgccg ccuggccucg gugggcguca       60

cuugugagcc ccacgcacgu ggggauggac cg                                     92


<210>  54
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  ʵʩ3Cas9ϵͳ˫ӫøϵͳĵRNA

<400>  54
ccgugaggac gcauugaccg guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugc                                 96


<210>  55
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  ʵʩ3D11Cϵͳ˫ӫøϵͳĵRNA

<400>  55
gucgcccccc acgcgggggc guggauugaa acauucucgg cggccgccag ggcgucggcc       60

ucggucgucg ccccccacgc gggggcgugg auugaaac                               98


<210>  56
<211>  154
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  I-E ϵͳ O2λ1O2-1˫RNA

<400>  56
gaguuccccg cgccagcggg gauaaaccga ggcgguaaug auggcgccug cggcggugag       60

uagaguuccc cgcgccagcg gggauaaacc ggagaucgag gaguacgcuu ggaugcucuu      120

cuuucgaguu ccccgcgcca gcggggauaa accg                                  154


<210>  57
<211>  153
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  I-E ϵͳ O2λ1O2-2˫RNA

<400>  57
gaguuccccg cgccagcggg gauaaaccga cauggacgga gaaguagaga uucugggguu       60

cgaguucccc gcgccagcgg ggauaaaccg guguguuugg augcacuaga uguaggugau      120

acaagaguuc cccgcgccag cggggauaaa ccg                                   153


<210>  58
<211>  164
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  I-C ϵͳPDL1λ˫RNA

<400>  58
gucgcccccc acgcgggggc guggauugaa acuugucaaa agugacaacu cuagggaugg       60

ugcuaggucg ccccccacgc gggggcgugg auugaaaccg uauucuagga cauucaaaca      120

gcuggcauac aggucgcccc ccacgcgggg gcguggauug aaac                       164


<210>  59
<211>  164
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  I-C ϵͳGL2λ˫RNA

<400>  59
gucgcccccc acgcgggggc guggauugaa acagagaagc gguccagucu gaacuaguag       60

uagugggucg ccccccacgc gggggcgugg auugaaacag cugggcgcac cucaucggcg      120

acaucccguc gggucgcccc ccacgcgggg gcguggauug aaac                       164


<210>  60
<211>  164
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  I-C ϵͳIPK1λ˫RNA

<400>  60
gucgcccccc acgcgggggc guggauugaa acugggauau ggccccacag gaguugcuca       60

ugacuugucg ccccccacgc gggggcgugg auugaaacuu auaaguuuaa guuugcaacu      120

gucacucaca acgucgcccc ccacgcgggg gcguggauug aaac                       164


<210>  61
<211>  151
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  I-E ϵͳPDL1λ˫RNA

<400>  61
gaguuccccg cgccagcggg gauaaaccgu gccuuggccg cauucucaua cugaaacauc       60

agaguucccc gcgccagcgg ggauaaaccg aacccugaca accacccaua ccucaugaaa      120

uugaguuccc cgcgccagcg gggauaaacc g                                     151


<210>  62
<211>  151
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  I-E ϵͳGL2λ˫RNA

<400>  62
gaguuccccg cgccagcggg gauaaaccgc agguggcggc cgacgggaug ucgccgauga       60

ggaguucccc gcgccagcgg ggauaaaccg cucuaguacg uaucauaaua guacgcugcu      120

gcgaguuccc cgcgccagcg gggauaaacc g                                     151


<210>  63
<211>  151
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  I-E ϵͳIPK1λ˫RNA

<400>  63
gaguuccccg cgccagcggg gauaaaccgu accuuuaucu cuacagcuau gcagcugcua       60

cgaguucccc gcgccagcgg ggauaaaccg agagaauggu aguacagauu cugaguauga      120

uugaguuccc cgcgccagcg gggauaaacc g                                     151


<210>  64
<211>  167
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TadA8eװ

<400>  64

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val Leu Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Ala 
        35                  40                  45              


Ile Gly Leu His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Phe Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Trp Arg Asn Ser Lys Arg Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asn Val Leu Asn Tyr Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Cys Asp Phe Tyr Arg Met Pro Arg Gln Val Phe Asn Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Ile Asn 
                165         


<210>  65
<211>  501
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TadA8e׵ĺ

<400>  65
atgtctgagg tggagttttc ccacgagtac tggatgagac atgccctgac cctggccaag       60

agggcacggg atgagaggga ggtgcctgtg ggagccgtgc tggtgctgaa caatagagtg      120

atcggcgagg gctggaacag agccatcggc ctgcacgacc caacagccca tgccgaaatt      180

atggccctga gacagggcgg cctggtcatg cagaactaca gactgattga cgccaccctg      240

tacgtgacat tcgagccttg cgtgatgtgc gccggcgcca tgatccactc taggatcggc      300

cgcgtggtgt ttggatggag aaattctaaa agaggcgccg caggctccct gatgaacgtg      360

ctgaactacc ccggcatgaa tcaccgcgtc gaaattaccg agggaatcct ggcagatgaa      420

tgtgccgccc tgctgtgcga tttctatcgg atgcctagac aggtgttcaa tgctcagaag      480

aaggcccaga gctccatcaa c                                                501


<210>  66
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TadA8eI-C Cas8c ںϵ׼linker-3 

<400>  66

Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr 
1               5                   10                  15      


Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser 
            20                  25                  30          


<210>  67
<211>  820
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLS-(linker 2)-TadA8e -(linker3)-(I-C 
       Cas8c)ںϵ׵ĵİ

<400>  67

Met Pro Lys Lys Lys Arg Lys Val Gly Ser Gly Ser Glu Val Glu Phe 
1               5                   10                  15      


Ser His Glu Tyr Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala 
            20                  25                  30          


Arg Asp Glu Arg Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn 
        35                  40                  45              


Arg Val Ile Gly Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro 
    50                  55                  60                  


Thr Ala His Ala Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met 
65                  70                  75                  80  


Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro 
                85                  90                  95      


Cys Val Met Cys Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val 
            100                 105                 110         


Val Phe Gly Trp Arg Asn Ser Lys Arg Gly Ala Ala Gly Ser Leu Met 
        115                 120                 125             


Asn Val Leu Asn Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu 
    130                 135                 140                 


Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu Leu Cys Asp Phe Tyr Arg 
145                 150                 155                 160 


Met Pro Arg Gln Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Ile 
                165                 170                 175     


Asn Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly 
            180                 185                 190         


Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly 
        195                 200                 205             


Ser Ile Leu Gln Ala Leu His Gly Tyr Tyr Gln Arg Met Ser Ala Asp 
    210                 215                 220                 


Pro Asp Ala Gly Met Pro Pro Tyr Gly Thr Ser Met Glu Asn Ile Ser 
225                 230                 235                 240 


Phe Ala Leu Val Leu Asp Ala Lys Gly Thr Leu Arg Gly Ile Glu Asp 
                245                 250                 255     


Leu Arg Glu Gln Glu Gly Lys Lys Leu Arg Pro Arg Lys Met Leu Val 
            260                 265                 270         


Pro Ile Ala Glu Lys Lys Gly Asn Gly Ile Lys Pro Asn Phe Leu Trp 
        275                 280                 285             


Glu Asn Thr Ser Tyr Ile Leu Gly Val Asp Ala Lys Gly Lys Gln Glu 
    290                 295                 300                 


Arg Thr Asp Lys Cys His Ala Ala Phe Ile Ala His Ile Lys Ala Tyr 
305                 310                 315                 320 


Cys Asp Thr Ala Asp Gln Asp Leu Ala Ala Val Leu Gln Phe Leu Glu 
                325                 330                 335     


His Gly Glu Lys Asp Leu Ser Ala Phe Pro Val Ser Glu Glu Val Ile 
            340                 345                 350         


Gly Ser Asn Ile Val Phe Arg Ile Glu Gly Glu Pro Gly Phe Val His 
        355                 360                 365             


Glu Arg Pro Ala Ala Arg Gln Ala Trp Ala Asn Cys Leu Asn Arg Arg 
    370                 375                 380                 


Glu Gln Gly Leu Cys Gly Gln Cys Leu Ile Thr Gly Glu Arg Gln Lys 
385                 390                 395                 400 


Pro Ile Ala Gln Leu His Pro Ser Ile Lys Gly Gly Arg Asp Gly Val 
                405                 410                 415     


Arg Gly Ala Gln Ala Val Ala Ser Ile Val Ser Phe Asn Asn Thr Ala 
            420                 425                 430         


Phe Glu Ser Tyr Gly Lys Glu Gln Ser Ile Asn Ala Pro Val Ser Gln 
        435                 440                 445             


Glu Ala Ala Phe Ser Tyr Val Thr Ala Leu Asn Tyr Leu Leu Asn Pro 
    450                 455                 460                 


Ser Asn Arg Gln Lys Val Thr Ile Ala Asp Ala Thr Val Val Phe Trp 
465                 470                 475                 480 


Ala Glu Arg Ser Ser Pro Ala Glu Asp Ile Phe Ala Gly Met Phe Asp 
                485                 490                 495     


Pro Pro Ser Thr Thr Ala Lys Pro Glu Ser Ser Asn Gly Thr Pro Pro 
            500                 505                 510         


Glu Asp Ser Glu Glu Gly Ser Gln Pro Asp Thr Ala Arg Asp Asp Pro 
        515                 520                 525             


His Ala Ala Ala Arg Met His Asp Leu Leu Val Ala Ile Arg Ser Gly 
    530                 535                 540                 


Lys Arg Ala Thr Asp Ile Met Pro Asp Met Asp Glu Ser Val Arg Phe 
545                 550                 555                 560 


His Val Leu Gly Leu Ser Pro Asn Ala Ala Arg Leu Ser Val Arg Phe 
                565                 570                 575     


Trp Glu Val Asp Thr Val Gly His Met Leu Asp Lys Val Gly Arg His 
            580                 585                 590         


Tyr Arg Glu Leu Glu Ile Ile Pro Gln Phe Asn Asn Glu Gln Glu Phe 
        595                 600                 605             


Pro Ser Leu Ser Thr Leu Leu Arg Gln Thr Ala Val Leu Asn Lys Thr 
    610                 615                 620                 


Glu Asn Ile Ser Pro Val Leu Ala Gly Gly Leu Phe Arg Ala Met Leu 
625                 630                 635                 640 


Thr Gly Gly Pro Tyr Pro Gln Ser Leu Leu Pro Ala Val Leu Gly Arg 
                645                 650                 655     


Ile Arg Ala Glu His Ala Arg Pro Glu Asp Lys Ser Arg Tyr Arg Leu 
            660                 665                 670         


Glu Val Val Thr Tyr Tyr Arg Ala Ala Leu Ile Lys Ala Tyr Leu Ile 
        675                 680                 685             


Arg Asn Arg Lys Leu Glu Val Pro Val Ser Leu Asp Pro Ala Arg Thr 
    690                 695                 700                 


Asp Arg Pro Tyr Leu Leu Gly Arg Leu Phe Ala Val Leu Glu Lys Ala 
705                 710                 715                 720 


Gln Glu Asp Ala Val Pro Gly Ala Asn Ala Thr Ile Lys Asp Arg Tyr 
                725                 730                 735     


Leu Ala Ser Ala Ser Ala Asn Pro Gly Gln Val Phe His Met Leu Leu 
            740                 745                 750         


Lys Asn Ala Ser Asn His Thr Ala Lys Leu Arg Lys Asp Pro Glu Arg 
        755                 760                 765             


Lys Gly Ser Ala Ile His Tyr Glu Ile Met Met Gln Glu Ile Ile Asp 
    770                 775                 780                 


Asn Ile Ser Asp Phe Pro Val Thr Met Ser Ser Asp Glu Gln Gly Leu 
785                 790                 795                 800 


Phe Met Ile Gly Tyr Tyr His Gln Arg Lys Ala Leu Phe Thr Lys Lys 
                805                 810                 815     


Asn Lys Glu Asn 
            820 


<210>  68
<211>  164
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  ʵʩ8I-CϵͳSLR1˫RNA

<400>  68
gucgcccccc acgcgggggc guggauugaa acaaagaagc cgcuaccacc gccgccggug       60

acaguggucg ccccccacgc gggggcgugg auugaaacgc gcacaccauu cgcgucgacu      120

uccaguaccg gggucgcccc ccacgcgggg gcguggauug aaac                       164


<210>  69
<211>  164
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  ʵʩ9I-CϵͳRBSC1BͬԴRBSC2BRBSC3B˫R
       NA

<400>  69
gucgcccccc acgcgggggc guggauugaa acggaugcac cgacuccgcu caaguguuga       60

aggaaggucg ccccccacgc gggggcgugg auugaaacag uugcacuaau ugcacaugac      120

aaaagacagu uugucgcccc ccacgcgggg gcguggauug aaac                       164


