                         SEQUENCE LISTING

<110>  University of Copenhagen
 
<120>  Mutant Cas12j endonucleases

<130>  P5942PC00

<160>  39    

<170>  PatentIn version 3.5

<210>  1
<211>  707
<212>  PRT
<213>  Biggiephage

<400>  1

Met Ala Asp Thr Pro Thr Leu Phe Thr Gln Phe Leu Arg His His Leu 
1               5                   10                  15      


Pro Gly Gln Arg Phe Arg Lys Asp Ile Leu Lys Gln Ala Gly Arg Ile 
            20                  25                  30          


Leu Ala Asn Lys Gly Glu Asp Ala Thr Ile Ala Phe Leu Arg Gly Lys 
        35                  40                  45              


Ser Glu Glu Ser Pro Pro Asp Phe Gln Pro Pro Val Lys Cys Pro Ile 
    50                  55                  60                  


Ile Ala Cys Ser Arg Pro Leu Thr Glu Trp Pro Ile Tyr Gln Ala Ser 
65                  70                  75                  80  


Val Ala Ile Gln Gly Tyr Val Tyr Gly Gln Ser Leu Ala Glu Phe Glu 
                85                  90                  95      


Ala Ser Asp Pro Gly Cys Ser Lys Asp Gly Leu Leu Gly Trp Phe Asp 
            100                 105                 110         


Lys Thr Gly Val Cys Thr Asp Tyr Phe Ser Val Gln Gly Leu Asn Leu 
        115                 120                 125             


Ile Phe Gln Asn Ala Arg Lys Arg Tyr Ile Gly Val Gln Thr Lys Val 
    130                 135                 140                 


Thr Asn Arg Asn Glu Lys Arg His Lys Lys Leu Lys Arg Ile Asn Ala 
145                 150                 155                 160 


Lys Arg Ile Ala Glu Gly Leu Pro Glu Leu Thr Ser Asp Glu Pro Glu 
                165                 170                 175     


Ser Ala Leu Asp Glu Thr Gly His Leu Ile Asp Pro Pro Gly Leu Asn 
            180                 185                 190         


Thr Asn Ile Tyr Cys Tyr Gln Gln Val Ser Pro Lys Pro Leu Ala Leu 
        195                 200                 205             


Ser Glu Val Asn Gln Leu Pro Thr Ala Tyr Ala Gly Tyr Ser Thr Ser 
    210                 215                 220                 


Gly Asp Asp Pro Ile Gln Pro Met Val Thr Lys Asp Arg Leu Ser Ile 
225                 230                 235                 240 


Ser Lys Gly Gln Pro Gly Tyr Ile Pro Glu His Gln Arg Ala Leu Leu 
                245                 250                 255     


Ser Gln Lys Lys His Arg Arg Met Arg Gly Tyr Gly Leu Lys Ala Arg 
            260                 265                 270         


Ala Leu Leu Val Ile Val Arg Ile Gln Asp Asp Trp Ala Val Ile Asp 
        275                 280                 285             


Leu Arg Ser Leu Leu Arg Asn Ala Tyr Trp Arg Arg Ile Val Gln Thr 
    290                 295                 300                 


Lys Glu Pro Ser Thr Ile Thr Lys Leu Leu Lys Leu Val Thr Gly Asp 
305                 310                 315                 320 


Pro Val Leu Asp Ala Thr Arg Met Val Ala Thr Phe Thr Tyr Lys Pro 
                325                 330                 335     


Gly Ile Val Gln Val Arg Ser Ala Lys Cys Leu Lys Asn Lys Gln Gly 
            340                 345                 350         


Ser Lys Leu Phe Ser Glu Arg Tyr Leu Asn Glu Thr Val Ser Val Thr 
        355                 360                 365             


Ser Ile Asp Leu Gly Ser Asn Asn Leu Val Ala Val Ala Thr Tyr Arg 
    370                 375                 380                 


Leu Val Asn Gly Asn Thr Pro Glu Leu Leu Gln Arg Phe Thr Leu Pro 
385                 390                 395                 400 


Ser His Leu Val Lys Asp Phe Glu Arg Tyr Lys Gln Ala His Asp Thr 
                405                 410                 415     


Leu Glu Asp Ser Ile Gln Lys Thr Ala Val Ala Ser Leu Pro Gln Gly 
            420                 425                 430         


Gln Gln Thr Glu Ile Arg Met Trp Ser Met Tyr Gly Phe Arg Glu Ala 
        435                 440                 445             


Gln Glu Arg Val Cys Gln Glu Leu Gly Leu Ala Asp Gly Ser Ile Pro 
    450                 455                 460                 


Trp Asn Val Met Thr Ala Thr Ser Thr Ile Leu Thr Asp Leu Phe Leu 
465                 470                 475                 480 


Ala Arg Gly Gly Asp Pro Lys Lys Cys Met Phe Thr Ser Glu Pro Lys 
                485                 490                 495     


Lys Lys Lys Asn Ser Lys Gln Val Leu Tyr Lys Ile Arg Asp Arg Ala 
            500                 505                 510         


Trp Ala Lys Met Tyr Arg Thr Leu Leu Ser Lys Glu Thr Arg Glu Ala 
        515                 520                 525             


Trp Asn Lys Ala Leu Trp Gly Leu Lys Arg Gly Ser Pro Asp Tyr Ala 
    530                 535                 540                 


Arg Leu Ser Lys Arg Lys Glu Glu Leu Ala Arg Arg Cys Val Asn Tyr 
545                 550                 555                 560 


Thr Ile Ser Thr Ala Glu Lys Arg Ala Gln Cys Gly Arg Thr Ile Val 
                565                 570                 575     


Ala Leu Glu Asp Leu Asn Ile Gly Phe Phe His Gly Arg Gly Lys Gln 
            580                 585                 590         


Glu Pro Gly Trp Val Gly Leu Phe Thr Arg Lys Lys Glu Asn Arg Trp 
        595                 600                 605             


Leu Met Gln Ala Leu His Lys Ala Phe Leu Glu Leu Ala His His Arg 
    610                 615                 620                 


Gly Tyr His Val Ile Glu Val Asn Pro Ala Tyr Thr Ser Gln Thr Cys 
625                 630                 635                 640 


Pro Val Cys Arg His Cys Asp Pro Asp Asn Arg Asp Gln His Asn Arg 
                645                 650                 655     


Glu Ala Phe His Cys Ile Gly Cys Gly Phe Arg Gly Asn Ala Asp Leu 
            660                 665                 670         


Asp Val Ala Thr His Asn Ile Ala Met Val Ala Ile Thr Gly Glu Ser 
        675                 680                 685             


Leu Lys Arg Ala Arg Gly Ser Val Ala Ser Lys Thr Pro Gln Pro Leu 
    690                 695                 700                 


Ala Ala Glu 
705         


<210>  2
<211>  757
<212>  PRT
<213>  Biggiephage

<400>  2

Met Pro Lys Pro Ala Val Glu Ser Glu Phe Ser Lys Val Leu Lys Lys 
1               5                   10                  15      


His Phe Pro Gly Glu Arg Phe Arg Ser Ser Tyr Met Lys Arg Gly Gly 
            20                  25                  30          


Lys Ile Leu Ala Ala Gln Gly Glu Glu Ala Val Val Ala Tyr Leu Gln 
        35                  40                  45              


Gly Lys Ser Glu Glu Glu Pro Pro Asn Phe Gln Pro Pro Ala Lys Cys 
    50                  55                  60                  


His Val Val Thr Lys Ser Arg Asp Phe Ala Glu Trp Pro Ile Met Lys 
65                  70                  75                  80  


Ala Ser Glu Ala Ile Gln Arg Tyr Ile Tyr Ala Leu Ser Thr Thr Glu 
                85                  90                  95      


Arg Ala Ala Cys Lys Pro Gly Lys Ser Ser Glu Ser His Ala Ala Trp 
            100                 105                 110         


Phe Ala Ala Thr Gly Val Ser Asn His Gly Tyr Ser His Val Gln Gly 
        115                 120                 125             


Leu Asn Leu Ile Phe Asp His Thr Leu Gly Arg Tyr Asp Gly Val Leu 
    130                 135                 140                 


Lys Lys Val Gln Leu Arg Asn Glu Lys Ala Arg Ala Arg Leu Glu Ser 
145                 150                 155                 160 


Ile Asn Ala Ser Arg Ala Asp Glu Gly Leu Pro Glu Ile Lys Ala Glu 
                165                 170                 175     


Glu Glu Glu Val Ala Thr Asn Glu Thr Gly His Leu Leu Gln Pro Pro 
            180                 185                 190         


Gly Ile Asn Pro Ser Phe Tyr Val Tyr Gln Thr Ile Ser Pro Gln Ala 
        195                 200                 205             


Tyr Arg Pro Arg Asp Glu Ile Val Leu Pro Pro Glu Tyr Ala Gly Tyr 
    210                 215                 220                 


Val Arg Asp Pro Asn Ala Pro Ile Pro Leu Gly Val Val Arg Asn Arg 
225                 230                 235                 240 


Cys Asp Ile Gln Lys Gly Cys Pro Gly Tyr Ile Pro Glu Trp Gln Arg 
                245                 250                 255     


Glu Ala Gly Thr Ala Ile Ser Pro Lys Thr Gly Lys Ala Val Thr Val 
            260                 265                 270         


Pro Gly Leu Ser Pro Lys Lys Asn Lys Arg Met Arg Arg Tyr Trp Arg 
        275                 280                 285             


Ser Glu Lys Glu Lys Ala Gln Asp Ala Leu Leu Val Thr Val Arg Ile 
    290                 295                 300                 


Gly Thr Asp Trp Val Val Ile Asp Val Arg Gly Leu Leu Arg Asn Ala 
305                 310                 315                 320 


Arg Trp Arg Thr Ile Ala Pro Lys Asp Ile Ser Leu Asn Ala Leu Leu 
                325                 330                 335     


Asp Leu Phe Thr Gly Asp Pro Val Ile Asp Val Arg Arg Asn Ile Val 
            340                 345                 350         


Thr Phe Thr Tyr Thr Leu Asp Ala Cys Gly Thr Tyr Ala Arg Lys Trp 
        355                 360                 365             


Thr Leu Lys Gly Lys Gln Thr Lys Ala Thr Leu Asp Lys Leu Thr Ala 
    370                 375                 380                 


Thr Gln Thr Val Ala Leu Val Ala Ile Asp Leu Gly Gln Thr Asn Pro 
385                 390                 395                 400 


Ile Ser Ala Gly Ile Ser Arg Val Thr Gln Glu Asn Gly Ala Leu Gln 
                405                 410                 415     


Cys Glu Pro Leu Asp Arg Phe Thr Leu Pro Asp Asp Leu Leu Lys Asp 
            420                 425                 430         


Ile Ser Ala Tyr Arg Ile Ala Trp Asp Arg Asn Glu Glu Glu Leu Arg 
        435                 440                 445             


Ala Arg Ser Val Glu Ala Leu Pro Glu Ala Gln Gln Ala Glu Val Arg 
    450                 455                 460                 


Ala Leu Asp Gly Val Ser Lys Glu Thr Ala Arg Thr Gln Leu Cys Ala 
465                 470                 475                 480 


Asp Phe Gly Leu Asp Pro Lys Arg Leu Pro Trp Asp Lys Met Ser Ser 
                485                 490                 495     


Asn Thr Thr Phe Ile Ser Glu Ala Leu Leu Ser Asn Ser Val Ser Arg 
            500                 505                 510         


Asp Gln Val Phe Phe Thr Pro Ala Pro Lys Lys Gly Ala Lys Lys Lys 
        515                 520                 525             


Ala Pro Val Glu Val Met Arg Lys Asp Arg Thr Trp Ala Arg Ala Tyr 
    530                 535                 540                 


Lys Pro Arg Leu Ser Val Glu Ala Gln Lys Leu Lys Asn Glu Ala Leu 
545                 550                 555                 560 


Trp Ala Leu Lys Arg Thr Ser Pro Glu Tyr Leu Lys Leu Ser Arg Arg 
                565                 570                 575     


Lys Glu Glu Leu Cys Arg Arg Ser Ile Asn Tyr Val Ile Glu Lys Thr 
            580                 585                 590         


Arg Arg Arg Thr Gln Cys Gln Ile Val Ile Pro Val Ile Glu Asp Leu 
        595                 600                 605             


Asn Val Arg Phe Phe His Gly Ser Gly Lys Arg Leu Pro Gly Trp Asp 
    610                 615                 620                 


Asn Phe Phe Thr Ala Lys Lys Glu Asn Arg Trp Phe Ile Gln Gly Leu 
625                 630                 635                 640 


His Lys Ala Phe Ser Asp Leu Arg Thr His Arg Ser Phe Tyr Val Phe 
                645                 650                 655     


Glu Val Arg Pro Glu Arg Thr Ser Ile Thr Cys Pro Lys Cys Gly His 
            660                 665                 670         


Cys Glu Val Gly Asn Arg Asp Gly Glu Ala Phe Gln Cys Leu Ser Cys 
        675                 680                 685             


Gly Lys Thr Cys Asn Ala Asp Leu Asp Val Ala Thr His Asn Leu Thr 
    690                 695                 700                 


Gln Val Ala Leu Thr Gly Lys Thr Met Pro Lys Arg Glu Glu Pro Arg 
705                 710                 715                 720 


Asp Ala Gln Gly Thr Ala Pro Ala Arg Lys Thr Lys Lys Ala Ser Lys 
                725                 730                 735     


Ser Lys Ala Pro Pro Ala Glu Arg Glu Asp Gln Thr Pro Ala Gln Glu 
            740                 745                 750         


Pro Ser Gln Thr Ser 
        755         


<210>  3
<211>  766
<212>  PRT
<213>  Biggiephage

<400>  3

Met Glu Lys Glu Ile Thr Glu Leu Thr Lys Ile Arg Arg Glu Phe Pro 
1               5                   10                  15      


Asn Lys Lys Phe Ser Ser Thr Asp Met Lys Lys Ala Gly Lys Leu Leu 
            20                  25                  30          


Lys Ala Glu Gly Pro Asp Ala Val Arg Asp Phe Leu Asn Ser Cys Gln 
        35                  40                  45              


Glu Ile Ile Gly Asp Phe Lys Pro Pro Val Lys Thr Asn Ile Val Ser 
    50                  55                  60                  


Ile Ser Arg Pro Phe Glu Glu Trp Pro Val Ser Met Val Gly Arg Ala 
65                  70                  75                  80  


Ile Gln Glu Tyr Tyr Phe Ser Leu Thr Lys Glu Glu Leu Glu Ser Val 
                85                  90                  95      


His Pro Gly Thr Ser Ser Glu Asp His Lys Ser Phe Phe Asn Ile Thr 
            100                 105                 110         


Gly Leu Ser Asn Tyr Asn Tyr Thr Ser Val Gln Gly Leu Asn Leu Ile 
        115                 120                 125             


Phe Lys Asn Ala Lys Ala Ile Tyr Asp Gly Thr Leu Val Lys Ala Asn 
    130                 135                 140                 


Asn Lys Asn Lys Lys Leu Glu Lys Lys Phe Asn Glu Ile Asn His Lys 
145                 150                 155                 160 


Arg Ser Leu Glu Gly Leu Pro Ile Ile Thr Pro Asp Phe Glu Glu Pro 
                165                 170                 175     


Phe Asp Glu Asn Gly His Leu Asn Asn Pro Pro Gly Ile Asn Arg Asn 
            180                 185                 190         


Ile Tyr Gly Tyr Gln Gly Cys Ala Ala Lys Val Phe Val Pro Ser Lys 
        195                 200                 205             


His Lys Met Val Ser Leu Pro Lys Glu Tyr Glu Gly Tyr Asn Arg Asp 
    210                 215                 220                 


Pro Asn Leu Ser Leu Ala Gly Phe Arg Asn Arg Leu Glu Ile Pro Glu 
225                 230                 235                 240 


Gly Glu Pro Gly His Val Pro Trp Phe Gln Arg Met Asp Ile Pro Glu 
                245                 250                 255     


Gly Gln Ile Gly His Val Asn Lys Ile Gln Arg Phe Asn Phe Val His 
            260                 265                 270         


Gly Lys Asn Ser Gly Lys Val Lys Phe Ser Asp Lys Thr Gly Arg Val 
        275                 280                 285             


Lys Arg Tyr His His Ser Lys Tyr Lys Asp Ala Thr Lys Pro Tyr Lys 
    290                 295                 300                 


Phe Leu Glu Glu Ser Lys Lys Val Ser Ala Leu Asp Ser Ile Leu Ala 
305                 310                 315                 320 


Ile Ile Thr Ile Gly Asp Asp Trp Val Val Phe Asp Ile Arg Gly Leu 
                325                 330                 335     


Tyr Arg Asn Val Phe Tyr Arg Glu Leu Ala Gln Lys Gly Leu Thr Ala 
            340                 345                 350         


Val Gln Leu Leu Asp Leu Phe Thr Gly Asp Pro Val Ile Asp Pro Lys 
        355                 360                 365             


Lys Gly Val Val Thr Phe Ser Tyr Lys Glu Gly Val Val Pro Val Phe 
    370                 375                 380                 


Ser Gln Lys Ile Val Pro Arg Phe Lys Ser Arg Asp Thr Leu Glu Lys 
385                 390                 395                 400 


Leu Thr Ser Gln Gly Pro Val Ala Leu Leu Ser Val Asp Leu Gly Gln 
                405                 410                 415     


Asn Glu Pro Val Ala Ala Arg Val Cys Ser Leu Lys Asn Ile Asn Asp 
            420                 425                 430         


Lys Ile Thr Leu Asp Asn Ser Cys Arg Ile Ser Phe Leu Asp Asp Tyr 
        435                 440                 445             


Lys Lys Gln Ile Lys Asp Tyr Arg Asp Ser Leu Asp Glu Leu Glu Ile 
    450                 455                 460                 


Lys Ile Arg Leu Glu Ala Ile Asn Ser Leu Glu Thr Asn Gln Gln Val 
465                 470                 475                 480 


Glu Ile Arg Asp Leu Asp Val Phe Ser Ala Asp Arg Ala Lys Ala Asn 
                485                 490                 495     


Thr Val Asp Met Phe Asp Ile Asp Pro Asn Leu Ile Ser Trp Asp Ser 
            500                 505                 510         


Met Ser Asp Ala Arg Val Ser Thr Gln Ile Ser Asp Leu Tyr Leu Lys 
        515                 520                 525             


Asn Gly Gly Asp Glu Ser Arg Val Tyr Phe Glu Ile Asn Asn Lys Arg 
    530                 535                 540                 


Ile Lys Arg Ser Asp Tyr Asn Ile Ser Gln Leu Val Arg Pro Lys Leu 
545                 550                 555                 560 


Ser Asp Ser Thr Arg Lys Asn Leu Asn Asp Ser Ile Trp Lys Leu Lys 
                565                 570                 575     


Arg Thr Ser Glu Glu Tyr Leu Lys Leu Ser Lys Arg Lys Leu Glu Leu 
            580                 585                 590         


Ser Arg Ala Val Val Asn Tyr Thr Ile Arg Gln Ser Lys Leu Leu Ser 
        595                 600                 605             


Gly Ile Asn Asp Ile Val Ile Ile Leu Glu Asp Leu Asp Val Lys Lys 
    610                 615                 620                 


Lys Phe Asn Gly Arg Gly Ile Arg Asp Ile Gly Trp Asp Asn Phe Phe 
625                 630                 635                 640 


Ser Ser Arg Lys Glu Asn Arg Trp Phe Ile Pro Ala Phe His Lys Ala 
                645                 650                 655     


Phe Ser Glu Leu Ser Ser Asn Arg Gly Leu Cys Val Ile Glu Val Asn 
            660                 665                 670         


Pro Ala Trp Thr Ser Ala Thr Cys Pro Asp Cys Gly Phe Cys Ser Lys 
        675                 680                 685             


Glu Asn Arg Asp Gly Ile Asn Phe Thr Cys Arg Lys Cys Gly Val Ser 
    690                 695                 700                 


Tyr His Ala Asp Ile Asp Val Ala Thr Leu Asn Ile Ala Arg Val Ala 
705                 710                 715                 720 


Val Leu Gly Lys Pro Met Ser Gly Pro Ala Asp Arg Glu Arg Leu Gly 
                725                 730                 735     


Asp Thr Lys Lys Pro Arg Val Ala Arg Ser Arg Lys Thr Met Lys Arg 
            740                 745                 750         


Lys Asp Ile Ser Asn Ser Thr Val Glu Ala Met Val Thr Ala 
        755                 760                 765     


<210>  4
<211>  765
<212>  PRT
<213>  Biggiephage

<400>  4

Met Tyr Ser Leu Glu Met Ala Asp Leu Lys Ser Glu Pro Ser Leu Leu 
1               5                   10                  15      


Ala Lys Leu Leu Arg Asp Arg Phe Pro Gly Lys Tyr Trp Leu Pro Lys 
            20                  25                  30          


Tyr Trp Lys Leu Ala Glu Lys Lys Arg Leu Thr Gly Gly Glu Glu Ala 
        35                  40                  45              


Ala Cys Glu Tyr Met Ala Asp Lys Gln Leu Asp Ser Pro Pro Pro Asn 
    50                  55                  60                  


Phe Arg Pro Pro Ala Arg Cys Val Ile Leu Ala Lys Ser Arg Pro Phe 
65                  70                  75                  80  


Glu Asp Trp Pro Val His Arg Val Ala Ser Lys Ala Gln Ser Phe Val 
                85                  90                  95      


Ile Gly Leu Ser Glu Gln Gly Phe Ala Ala Leu Arg Ala Ala Pro Pro 
            100                 105                 110         


Ser Thr Ala Asp Ala Arg Arg Asp Trp Leu Arg Ser His Gly Ala Ser 
        115                 120                 125             


Glu Asp Asp Leu Met Ala Leu Glu Ala Gln Leu Leu Glu Thr Ile Met 
    130                 135                 140                 


Gly Asn Ala Ile Ser Leu His Gly Gly Val Leu Lys Lys Ile Asp Asn 
145                 150                 155                 160 


Ala Asn Val Lys Ala Ala Lys Arg Leu Ser Gly Arg Asn Glu Ala Arg 
                165                 170                 175     


Leu Asn Lys Gly Leu Gln Glu Leu Pro Pro Glu Gln Glu Gly Ser Ala 
            180                 185                 190         


Tyr Gly Ala Asp Gly Leu Leu Val Asn Pro Pro Gly Leu Asn Leu Asn 
        195                 200                 205             


Ile Tyr Cys Arg Lys Ser Cys Cys Pro Lys Pro Val Lys Asn Thr Ala 
    210                 215                 220                 


Arg Phe Val Gly His Tyr Pro Gly Tyr Leu Arg Asp Ser Asp Ser Ile 
225                 230                 235                 240 


Leu Ile Ser Gly Thr Met Asp Arg Leu Thr Ile Ile Glu Gly Met Pro 
                245                 250                 255     


Gly His Ile Pro Ala Trp Gln Arg Glu Gln Gly Leu Val Lys Pro Gly 
            260                 265                 270         


Gly Arg Arg Arg Arg Leu Ser Gly Ser Glu Ser Asn Met Arg Gln Lys 
        275                 280                 285             


Val Asp Pro Ser Thr Gly Pro Arg Arg Ser Thr Arg Ser Gly Thr Val 
    290                 295                 300                 


Asn Arg Ser Asn Gln Arg Thr Gly Arg Asn Gly Asp Pro Leu Leu Val 
305                 310                 315                 320 


Glu Ile Arg Met Lys Glu Asp Trp Val Leu Leu Asp Ala Arg Gly Leu 
                325                 330                 335     


Leu Arg Asn Leu Arg Trp Arg Glu Ser Lys Arg Gly Leu Ser Cys Asp 
            340                 345                 350         


His Glu Asp Leu Ser Leu Ser Gly Leu Leu Ala Leu Phe Ser Gly Asp 
        355                 360                 365             


Pro Val Ile Asp Pro Val Arg Asn Glu Val Val Phe Leu Tyr Gly Glu 
    370                 375                 380                 


Gly Ile Ile Pro Val Arg Ser Thr Lys Pro Val Gly Thr Arg Gln Ser 
385                 390                 395                 400 


Lys Lys Leu Leu Glu Arg Gln Ala Ser Met Gly Pro Leu Thr Leu Ile 
                405                 410                 415     


Ser Cys Asp Leu Gly Gln Thr Asn Leu Ile Ala Gly Arg Ala Ser Ala 
            420                 425                 430         


Ile Ser Leu Thr His Gly Ser Leu Gly Val Arg Ser Ser Val Arg Ile 
        435                 440                 445             


Glu Leu Asp Pro Glu Ile Ile Lys Ser Phe Glu Arg Leu Arg Lys Asp 
    450                 455                 460                 


Ala Asp Arg Leu Glu Thr Glu Ile Leu Thr Ala Ala Lys Glu Thr Leu 
465                 470                 475                 480 


Ser Asp Glu Gln Arg Gly Glu Val Asn Ser His Glu Lys Asp Ser Pro 
                485                 490                 495     


Gln Thr Ala Lys Ala Ser Leu Cys Arg Glu Leu Gly Leu His Pro Pro 
            500                 505                 510         


Ser Leu Pro Trp Gly Gln Met Gly Pro Ser Thr Thr Phe Ile Ala Asp 
        515                 520                 525             


Met Leu Ile Ser His Gly Arg Asp Asp Asp Ala Phe Leu Ser His Gly 
    530                 535                 540                 


Glu Phe Pro Thr Leu Glu Lys Arg Lys Lys Phe Asp Lys Arg Phe Cys 
545                 550                 555                 560 


Leu Glu Ser Arg Pro Leu Leu Ser Ser Glu Thr Arg Lys Ala Leu Asn 
                565                 570                 575     


Glu Ser Leu Trp Glu Val Lys Arg Thr Ser Ser Glu Tyr Ala Arg Leu 
            580                 585                 590         


Ser Gln Arg Lys Lys Glu Met Ala Arg Arg Ala Val Asn Phe Val Val 
        595                 600                 605             


Glu Ile Ser Arg Arg Lys Thr Gly Leu Ser Asn Val Ile Val Asn Ile 
    610                 615                 620                 


Glu Asp Leu Asn Val Arg Ile Phe His Gly Gly Gly Lys Gln Ala Pro 
625                 630                 635                 640 


Gly Trp Asp Gly Phe Phe Arg Pro Lys Ser Glu Asn Arg Trp Phe Ile 
                645                 650                 655     


Gln Ala Ile His Lys Ala Phe Ser Asp Leu Ala Ala His His Gly Ile 
            660                 665                 670         


Pro Val Ile Glu Ser Asp Pro Gln Arg Thr Ser Met Thr Cys Pro Glu 
        675                 680                 685             


Cys Gly His Cys Asp Ser Lys Asn Arg Asn Gly Val Arg Phe Leu Cys 
    690                 695                 700                 


Lys Gly Cys Gly Ala Ser Met Asp Ala Asp Phe Asp Ala Ala Cys Arg 
705                 710                 715                 720 


Asn Leu Glu Arg Val Ala Leu Thr Gly Lys Pro Met Pro Lys Pro Ser 
                725                 730                 735     


Thr Ser Cys Glu Arg Leu Leu Ser Ala Thr Thr Gly Lys Val Cys Ser 
            740                 745                 750         


Asp His Ser Leu Ser His Asp Ala Ile Glu Lys Ala Ser 
        755                 760                 765 


<210>  5
<211>  793
<212>  PRT
<213>  Biggiephage

<400>  5

Met Ser Ser Leu Pro Thr Pro Leu Glu Leu Leu Lys Gln Lys His Ala 
1               5                   10                  15      


Asp Leu Phe Lys Gly Leu Gln Phe Ser Ser Lys Asp Asn Lys Met Ala 
            20                  25                  30          


Gly Lys Val Leu Lys Lys Asp Gly Glu Glu Ala Ala Leu Ala Phe Leu 
        35                  40                  45              


Ser Glu Arg Gly Val Ser Arg Gly Glu Leu Pro Asn Phe Arg Pro Pro 
    50                  55                  60                  


Ala Lys Thr Leu Val Val Ala Gln Ser Arg Pro Phe Glu Glu Phe Pro 
65                  70                  75                  80  


Ile Tyr Arg Val Ser Glu Ala Ile Gln Leu Tyr Val Tyr Ser Leu Ser 
                85                  90                  95      


Val Lys Glu Leu Glu Thr Val Pro Ser Gly Ser Ser Thr Lys Lys Glu 
            100                 105                 110         


His Gln Arg Phe Phe Gln Asp Ser Ser Val Pro Asp Phe Gly Tyr Thr 
        115                 120                 125             


Ser Val Gln Gly Leu Asn Lys Ile Phe Gly Leu Ala Arg Gly Ile Tyr 
    130                 135                 140                 


Leu Gly Val Ile Thr Arg Gly Glu Asn Gln Leu Gln Lys Ala Lys Ser 
145                 150                 155                 160 


Lys His Glu Ala Leu Asn Lys Lys Arg Arg Ala Ser Gly Glu Ala Glu 
                165                 170                 175     


Thr Glu Phe Asp Pro Thr Pro Tyr Glu Tyr Met Thr Pro Glu Arg Lys 
            180                 185                 190         


Leu Ala Lys Pro Pro Gly Val Asn His Ser Ile Met Cys Tyr Val Asp 
        195                 200                 205             


Ile Ser Val Asp Glu Phe Asp Phe Arg Asn Pro Asp Gly Ile Val Leu 
    210                 215                 220                 


Pro Ser Glu Tyr Ala Gly Tyr Cys Arg Glu Ile Asn Thr Ala Ile Glu 
225                 230                 235                 240 


Lys Gly Thr Val Asp Arg Leu Gly His Leu Lys Gly Gly Pro Gly Tyr 
                245                 250                 255     


Ile Pro Gly His Gln Arg Lys Glu Ser Thr Thr Glu Gly Pro Lys Ile 
            260                 265                 270         


Asn Phe Arg Lys Gly Arg Ile Arg Arg Ser Tyr Thr Ala Leu Tyr Ala 
        275                 280                 285             


Lys Arg Asp Ser Arg Arg Val Arg Gln Gly Lys Leu Ala Leu Pro Ser 
    290                 295                 300                 


Tyr Arg His His Met Met Arg Leu Asn Ser Asn Ala Glu Ser Ala Ile 
305                 310                 315                 320 


Leu Ala Val Ile Phe Phe Gly Lys Asp Trp Val Val Phe Asp Leu Arg 
                325                 330                 335     


Gly Leu Leu Arg Asn Val Arg Trp Arg Asn Leu Phe Val Asp Gly Ser 
            340                 345                 350         


Thr Pro Ser Thr Leu Leu Gly Met Phe Gly Asp Pro Val Ile Asp Pro 
        355                 360                 365             


Lys Arg Gly Val Val Ala Phe Cys Tyr Lys Glu Gln Ile Val Pro Val 
    370                 375                 380                 


Val Ser Lys Ser Ile Thr Lys Met Val Lys Ala Pro Glu Leu Leu Asn 
385                 390                 395                 400 


Lys Leu Tyr Leu Lys Ser Glu Asp Pro Leu Val Leu Val Ala Ile Asp 
                405                 410                 415     


Leu Gly Gln Thr Asn Pro Val Gly Val Gly Val Tyr Arg Val Met Asn 
            420                 425                 430         


Ala Ser Leu Asp Tyr Glu Val Val Thr Arg Phe Ala Leu Glu Ser Glu 
        435                 440                 445             


Leu Leu Arg Glu Ile Glu Ser Tyr Arg Gln Arg Thr Asn Ala Phe Glu 
    450                 455                 460                 


Ala Gln Ile Arg Ala Glu Thr Phe Asp Ala Met Thr Ser Glu Glu Gln 
465                 470                 475                 480 


Glu Glu Ile Thr Arg Val Arg Ala Phe Ser Ala Ser Lys Ala Lys Glu 
                485                 490                 495     


Asn Val Cys His Arg Phe Gly Met Pro Val Asp Ala Val Asp Trp Ala 
            500                 505                 510         


Thr Met Gly Ser Asn Thr Ile His Ile Ala Lys Trp Val Met Arg His 
        515                 520                 525             


Gly Asp Pro Ser Leu Val Glu Val Leu Glu Tyr Arg Lys Asp Asn Glu 
    530                 535                 540                 


Ile Lys Leu Asp Lys Asn Gly Val Pro Lys Lys Val Lys Leu Thr Asp 
545                 550                 555                 560 


Lys Arg Ile Ala Asn Leu Thr Ser Ile Arg Leu Arg Phe Ser Gln Glu 
                565                 570                 575     


Thr Ser Lys His Tyr Asn Asp Thr Met Trp Glu Leu Arg Arg Lys His 
            580                 585                 590         


Pro Val Tyr Gln Lys Leu Ser Lys Ser Lys Ala Asp Phe Ser Arg Arg 
        595                 600                 605             


Val Val Asn Ser Ile Ile Arg Arg Val Asn His Leu Val Pro Arg Ala 
    610                 615                 620                 


Arg Ile Val Phe Ile Ile Glu Asp Leu Lys Asn Leu Gly Lys Val Phe 
625                 630                 635                 640 


His Gly Ser Gly Lys Arg Glu Leu Gly Trp Asp Ser Tyr Phe Glu Pro 
                645                 650                 655     


Lys Ser Glu Asn Arg Trp Phe Ile Gln Val Leu His Lys Ala Phe Ser 
            660                 665                 670         


Glu Thr Gly Lys His Lys Gly Tyr Tyr Ile Ile Glu Cys Trp Pro Asn 
        675                 680                 685             


Trp Thr Ser Cys Thr Cys Pro Lys Cys Ser Cys Cys Asp Ser Glu Asn 
    690                 695                 700                 


Arg His Gly Glu Val Phe Arg Cys Leu Ala Cys Gly Tyr Thr Cys Asn 
705                 710                 715                 720 


Thr Asp Phe Gly Thr Ala Pro Asp Asn Leu Val Lys Ile Ala Thr Thr 
                725                 730                 735     


Gly Lys Gly Leu Pro Gly Pro Lys Lys Arg Cys Lys Gly Ser Ser Lys 
            740                 745                 750         


Gly Lys Asn Pro Lys Ile Ala Arg Ser Ser Glu Thr Gly Val Ser Val 
        755                 760                 765             


Thr Glu Ser Gly Ala Pro Lys Val Lys Lys Ser Ser Pro Thr Gln Thr 
    770                 775                 780                 


Ser Gln Ser Ser Ser Gln Ser Ala Pro 
785                 790             


<210>  6
<211>  441
<212>  PRT
<213>  Biggiephage

<400>  6

Met Asn Lys Ile Glu Lys Glu Lys Thr Pro Leu Ala Lys Leu Met Asn 
1               5                   10                  15      


Glu Asn Phe Ala Gly Leu Arg Phe Pro Phe Ala Ile Ile Lys Gln Ala 
            20                  25                  30          


Gly Lys Lys Leu Leu Lys Glu Gly Glu Leu Lys Thr Ile Glu Tyr Met 
        35                  40                  45              


Thr Gly Lys Gly Ser Ile Glu Pro Leu Pro Asn Phe Lys Pro Pro Val 
    50                  55                  60                  


Lys Cys Leu Ile Val Ala Lys Arg Arg Asp Leu Lys Tyr Phe Pro Ile 
65                  70                  75                  80  


Cys Lys Ala Ser Cys Glu Ile Gln Ser Tyr Val Tyr Ser Leu Asn Tyr 
                85                  90                  95      


Lys Asp Phe Met Asp Tyr Phe Ser Thr Pro Met Thr Ser Gln Lys Gln 
            100                 105                 110         


His Glu Glu Phe Phe Lys Lys Ser Gly Leu Asn Ile Glu Tyr Gln Asn 
        115                 120                 125             


Val Ala Gly Leu Asn Leu Ile Phe Asn Asn Val Lys Asn Thr Tyr Asn 
    130                 135                 140                 


Gly Val Ile Leu Lys Val Lys Asn Arg Asn Glu Lys Leu Lys Lys Lys 
145                 150                 155                 160 


Ala Ile Lys Asn Asn Tyr Glu Phe Glu Glu Ile Lys Thr Phe Asn Asp 
                165                 170                 175     


Asp Gly Cys Leu Ile Asn Lys Pro Gly Ile Asn Asn Val Ile Tyr Cys 
            180                 185                 190         


Phe Gln Ser Ile Ser Pro Lys Ile Leu Lys Asn Ile Thr His Leu Pro 
        195                 200                 205             


Lys Glu Tyr Asn Asp Tyr Asp Cys Ser Val Asp Arg Asn Ile Ile Gln 
    210                 215                 220                 


Lys Tyr Val Ser Arg Leu Asp Ile Pro Glu Ser Gln Pro Gly His Val 
225                 230                 235                 240 


Pro Glu Trp Gln Arg Lys Leu Pro Glu Phe Asn Asn Thr Asn Asn Pro 
                245                 250                 255     


Arg Arg Arg Arg Lys Trp Tyr Ser Asn Gly Arg Asn Ile Ser Lys Gly 
            260                 265                 270         


Tyr Ser Val Asp Gln Val Asn Gln Ala Lys Ile Glu Asp Ser Leu Leu 
        275                 280                 285             


Ala Gln Ile Lys Ile Gly Glu Asp Trp Ile Ile Leu Asp Ile Arg Gly 
    290                 295                 300                 


Leu Leu Arg Asp Leu Asn Arg Arg Glu Leu Ile Ser Tyr Lys Asn Lys 
305                 310                 315                 320 


Leu Thr Ile Lys Asp Val Leu Gly Phe Phe Ser Asp Tyr Pro Ile Ile 
                325                 330                 335     


Asp Ile Lys Lys Asn Leu Val Thr Phe Cys Tyr Lys Glu Gly Val Ile 
            340                 345                 350         


Gln Val Val Ser Gln Lys Ser Ile Gly Asn Lys Lys Ser Lys Gln Leu 
        355                 360                 365             


Leu Glu Lys Leu Ile Glu Asn Lys Pro Ile Ala Leu Val Ser Ile Asp 
    370                 375                 380                 


Leu Gly Gln Thr Asn Pro Val Ser Val Lys Ile Ser Lys Leu Asn Lys 
385                 390                 395                 400 


Ile Asn Asn Lys Ile Ser Ile Glu Ser Phe Thr Tyr Arg Phe Leu Asn 
                405                 410                 415     


Glu Glu Ile Leu Lys Glu Ile Glu Lys Tyr Arg Lys Asp Tyr Asp Lys 
            420                 425                 430         


Leu Glu Leu Lys Leu Ile Asn Glu Ala 
        435                 440     


<210>  7
<211>  772
<212>  PRT
<213>  Biggiephage

<400>  7

Met Ser Asn Thr Ala Val Ser Thr Arg Glu His Met Ser Asn Lys Thr 
1               5                   10                  15      


Thr Pro Pro Ser Pro Leu Ser Leu Leu Leu Arg Ala His Phe Pro Gly 
            20                  25                  30          


Leu Lys Phe Glu Ser Gln Asp Tyr Lys Ile Ala Gly Lys Lys Leu Arg 
        35                  40                  45              


Asp Gly Gly Pro Glu Ala Val Ile Ser Tyr Leu Thr Gly Lys Gly Gln 
    50                  55                  60                  


Ala Lys Leu Lys Asp Val Lys Pro Pro Ala Lys Ala Phe Val Ile Ala 
65                  70                  75                  80  


Gln Ser Arg Pro Phe Ile Glu Trp Asp Leu Val Arg Val Ser Arg Gln 
                85                  90                  95      


Ile Gln Glu Lys Ile Phe Gly Ile Pro Ala Thr Lys Gly Arg Pro Lys 
            100                 105                 110         


Gln Asp Gly Leu Ser Glu Thr Ala Phe Asn Glu Ala Val Ala Ser Leu 
        115                 120                 125             


Glu Val Asp Gly Lys Ser Lys Leu Asn Glu Glu Thr Arg Ala Ala Phe 
    130                 135                 140                 


Tyr Glu Val Leu Gly Leu Asp Ala Pro Ser Leu His Ala Gln Ala Gln 
145                 150                 155                 160 


Asn Ala Leu Ile Lys Ser Ala Ile Ser Ile Arg Glu Gly Val Leu Lys 
                165                 170                 175     


Lys Val Glu Asn Arg Asn Glu Lys Asn Leu Ser Lys Thr Lys Arg Arg 
            180                 185                 190         


Lys Glu Ala Gly Glu Glu Ala Thr Phe Val Glu Glu Lys Ala His Asp 
        195                 200                 205             


Glu Arg Gly Tyr Leu Ile His Pro Pro Gly Val Asn Gln Thr Ile Pro 
    210                 215                 220                 


Gly Tyr Gln Ala Val Val Ile Lys Ser Cys Pro Ser Asp Phe Ile Gly 
225                 230                 235                 240 


Leu Pro Ser Gly Cys Leu Ala Lys Glu Ser Ala Glu Ala Leu Thr Asp 
                245                 250                 255     


Tyr Leu Pro His Asp Arg Met Thr Ile Pro Lys Gly Gln Pro Gly Tyr 
            260                 265                 270         


Val Pro Glu Trp Gln His Pro Leu Leu Asn Arg Arg Lys Asn Arg Arg 
        275                 280                 285             


Arg Arg Asp Trp Tyr Ser Ala Ser Leu Asn Lys Pro Lys Ala Thr Cys 
    290                 295                 300                 


Ser Lys Arg Ser Gly Thr Pro Asn Arg Lys Asn Ser Arg Thr Asp Gln 
305                 310                 315                 320 


Ile Gln Ser Gly Arg Phe Lys Gly Ala Ile Pro Val Leu Met Arg Phe 
                325                 330                 335     


Gln Asp Glu Trp Val Ile Ile Asp Ile Arg Gly Leu Leu Arg Asn Ala 
            340                 345                 350         


Arg Tyr Arg Lys Leu Leu Lys Glu Lys Ser Thr Ile Pro Asp Leu Leu 
        355                 360                 365             


Ser Leu Phe Thr Gly Asp Pro Ser Ile Asp Met Arg Gln Gly Val Cys 
    370                 375                 380                 


Thr Phe Ile Tyr Lys Ala Gly Gln Ala Cys Ser Ala Lys Met Val Lys 
385                 390                 395                 400 


Thr Lys Asn Ala Pro Glu Ile Leu Ser Glu Leu Thr Lys Ser Gly Pro 
                405                 410                 415     


Val Val Leu Val Ser Ile Asp Leu Gly Gln Thr Asn Pro Ile Ala Ala 
            420                 425                 430         


Lys Val Ser Arg Val Thr Gln Leu Ser Asp Gly Gln Leu Ser His Glu 
        435                 440                 445             


Thr Leu Leu Arg Glu Leu Leu Ser Asn Asp Ser Ser Asp Gly Lys Glu 
    450                 455                 460                 


Ile Ala Arg Tyr Arg Val Ala Ser Asp Arg Leu Arg Asp Lys Leu Ala 
465                 470                 475                 480 


Asn Leu Ala Val Glu Arg Leu Ser Pro Glu His Lys Ser Glu Ile Leu 
                485                 490                 495     


Arg Ala Lys Asn Asp Thr Pro Ala Leu Cys Lys Ala Arg Val Cys Ala 
            500                 505                 510         


Ala Leu Gly Leu Asn Pro Glu Met Ile Ala Trp Asp Lys Met Thr Pro 
        515                 520                 525             


Tyr Thr Glu Phe Leu Ala Thr Ala Tyr Leu Glu Lys Gly Gly Asp Arg 
    530                 535                 540                 


Lys Val Ala Thr Leu Lys Pro Lys Asn Arg Pro Glu Met Leu Arg Arg 
545                 550                 555                 560 


Asp Ile Lys Phe Lys Gly Thr Glu Gly Val Arg Ile Glu Val Ser Pro 
                565                 570                 575     


Glu Ala Ala Glu Ala Tyr Arg Glu Ala Gln Trp Asp Leu Gln Arg Thr 
            580                 585                 590         


Ser Pro Glu Tyr Leu Arg Leu Ser Thr Trp Lys Gln Glu Leu Thr Lys 
        595                 600                 605             


Arg Ile Leu Asn Gln Leu Arg His Lys Ala Ala Lys Ser Ser Gln Cys 
    610                 615                 620                 


Glu Val Val Val Met Ala Phe Glu Asp Leu Asn Ile Lys Met Met His 
625                 630                 635                 640 


Gly Asn Gly Lys Trp Ala Asp Gly Gly Trp Asp Ala Phe Phe Ile Lys 
                645                 650                 655     


Lys Arg Glu Asn Arg Trp Phe Met Gln Ala Phe His Lys Ser Leu Thr 
            660                 665                 670         


Glu Leu Gly Ala His Lys Gly Val Pro Thr Ile Glu Val Thr Pro His 
        675                 680                 685             


Arg Thr Ser Ile Thr Cys Thr Lys Cys Gly His Cys Asp Lys Ala Asn 
    690                 695                 700                 


Arg Asp Gly Glu Arg Phe Ala Cys Gln Lys Cys Gly Phe Val Ala His 
705                 710                 715                 720 


Ala Asp Leu Glu Ile Ala Thr Asp Asn Ile Glu Arg Val Ala Leu Thr 
                725                 730                 735     


Gly Lys Pro Met Pro Lys Pro Glu Ser Glu Arg Ser Gly Asp Ala Lys 
            740                 745                 750         


Lys Ser Val Gly Ala Arg Lys Ala Ala Phe Lys Pro Glu Glu Asp Ala 
        755                 760                 765             


Glu Ala Ala Glu 
    770         


<210>  8
<211>  717
<212>  PRT
<213>  Biggiephage

<400>  8

Met Ile Lys Pro Thr Val Ser Gln Phe Leu Thr Pro Gly Phe Lys Leu 
1               5                   10                  15      


Ile Arg Asn His Ser Arg Thr Ala Gly Leu Lys Leu Lys Asn Glu Gly 
            20                  25                  30          


Glu Glu Ala Cys Lys Lys Phe Val Arg Glu Asn Glu Ile Pro Lys Asp 
        35                  40                  45              


Glu Cys Pro Asn Phe Gln Gly Gly Pro Ala Ile Ala Asn Ile Ile Ala 
    50                  55                  60                  


Lys Ser Arg Glu Phe Thr Glu Trp Glu Ile Tyr Gln Ser Ser Leu Ala 
65                  70                  75                  80  


Ile Gln Glu Val Ile Phe Thr Leu Pro Lys Asp Lys Leu Pro Glu Pro 
                85                  90                  95      


Ile Leu Lys Glu Glu Trp Arg Ala Gln Trp Leu Ser Glu His Gly Leu 
            100                 105                 110         


Asp Thr Val Pro Tyr Lys Glu Ala Ala Gly Leu Asn Leu Ile Ile Lys 
        115                 120                 125             


Asn Ala Val Asn Thr Tyr Lys Gly Val Gln Val Lys Val Asp Asn Lys 
    130                 135                 140                 


Asn Lys Asn Asn Leu Ala Lys Ile Asn Arg Lys Asn Glu Ile Ala Lys 
145                 150                 155                 160 


Leu Asn Gly Glu Gln Glu Ile Ser Phe Glu Glu Ile Lys Ala Phe Asp 
                165                 170                 175     


Asp Lys Gly Tyr Leu Leu Gln Lys Pro Ser Pro Asn Lys Ser Ile Tyr 
            180                 185                 190         


Cys Tyr Gln Ser Val Ser Pro Lys Pro Phe Ile Thr Ser Lys Tyr His 
        195                 200                 205             


Asn Val Asn Leu Pro Glu Glu Tyr Ile Gly Tyr Tyr Arg Lys Ser Asn 
    210                 215                 220                 


Glu Pro Ile Val Ser Pro Tyr Gln Phe Asp Arg Leu Arg Ile Pro Ile 
225                 230                 235                 240 


Gly Glu Pro Gly Tyr Val Pro Lys Trp Gln Tyr Thr Phe Leu Ser Lys 
                245                 250                 255     


Lys Glu Asn Lys Arg Arg Lys Leu Ser Lys Arg Ile Lys Asn Val Ser 
            260                 265                 270         


Pro Ile Leu Gly Ile Ile Cys Ile Lys Lys Asp Trp Cys Val Phe Asp 
        275                 280                 285             


Met Arg Gly Leu Leu Arg Thr Asn His Trp Lys Lys Tyr His Lys Pro 
    290                 295                 300                 


Thr Asp Ser Ile Asn Asp Leu Phe Asp Tyr Phe Thr Gly Asp Pro Val 
305                 310                 315                 320 


Ile Asp Thr Lys Ala Asn Val Val Arg Phe Arg Tyr Lys Met Glu Asn 
                325                 330                 335     


Gly Ile Val Asn Tyr Lys Pro Val Arg Glu Lys Lys Gly Lys Glu Leu 
            340                 345                 350         


Leu Glu Asn Ile Cys Asp Gln Asn Gly Ser Cys Lys Leu Ala Thr Val 
        355                 360                 365             


Asp Val Gly Gln Asn Asn Pro Val Ala Ile Gly Leu Phe Glu Leu Lys 
    370                 375                 380                 


Lys Val Asn Gly Glu Leu Thr Lys Thr Leu Ile Ser Arg His Pro Thr 
385                 390                 395                 400 


Pro Ile Asp Phe Cys Asn Lys Ile Thr Ala Tyr Arg Glu Arg Tyr Asp 
                405                 410                 415     


Lys Leu Glu Ser Ser Ile Lys Leu Asp Ala Ile Lys Gln Leu Thr Ser 
            420                 425                 430         


Glu Gln Lys Ile Glu Val Asp Asn Tyr Asn Asn Asn Phe Thr Pro Gln 
        435                 440                 445             


Asn Thr Lys Gln Ile Val Cys Ser Lys Leu Asn Ile Asn Pro Asn Asp 
    450                 455                 460                 


Leu Pro Trp Asp Lys Met Ile Ser Gly Thr His Phe Ile Ser Glu Lys 
465                 470                 475                 480 


Ala Gln Val Ser Asn Lys Ser Glu Ile Tyr Phe Thr Ser Thr Asp Lys 
                485                 490                 495     


Gly Lys Thr Lys Asp Val Met Lys Ser Asp Tyr Lys Trp Phe Gln Asp 
            500                 505                 510         


Tyr Lys Pro Lys Leu Ser Lys Glu Val Arg Asp Ala Leu Ser Asp Ile 
        515                 520                 525             


Glu Trp Arg Leu Arg Arg Glu Ser Leu Glu Phe Asn Lys Leu Ser Lys 
    530                 535                 540                 


Ser Arg Glu Gln Asp Ala Arg Gln Leu Ala Asn Trp Ile Ser Ser Met 
545                 550                 555                 560 


Cys Asp Val Ile Gly Ile Glu Asn Leu Val Lys Lys Asn Asn Phe Phe 
                565                 570                 575     


Gly Gly Ser Gly Lys Arg Glu Pro Gly Trp Asp Asn Phe Tyr Lys Pro 
            580                 585                 590         


Lys Lys Glu Asn Arg Trp Trp Ile Asn Ala Ile His Lys Ala Leu Thr 
        595                 600                 605             


Glu Leu Ser Gln Asn Lys Gly Lys Arg Val Ile Leu Leu Pro Ala Met 
    610                 615                 620                 


Arg Thr Ser Ile Thr Cys Pro Lys Cys Lys Tyr Cys Asp Ser Lys Asn 
625                 630                 635                 640 


Arg Asn Gly Glu Lys Phe Asn Cys Leu Lys Cys Gly Ile Glu Leu Asn 
                645                 650                 655     


Ala Asp Ile Asp Val Ala Thr Glu Asn Leu Ala Thr Val Ala Ile Thr 
            660                 665                 670         


Ala Gln Ser Met Pro Lys Pro Thr Cys Glu Arg Ser Gly Asp Ala Lys 
        675                 680                 685             


Lys Pro Val Arg Ala Arg Lys Ala Lys Ala Pro Glu Phe His Asp Lys 
    690                 695                 700                 


Leu Ala Pro Ser Tyr Thr Val Val Leu Arg Glu Ala Val 
705                 710                 715         


<210>  9
<211>  793
<212>  PRT
<213>  Biggiephage

<400>  9

Met Arg Ser Ser Arg Glu Ile Gly Asp Lys Ile Leu Met Arg Gln Pro 
1               5                   10                  15      


Ala Glu Lys Thr Ala Phe Gln Val Phe Arg Gln Glu Val Ile Gly Thr 
            20                  25                  30          


Gln Lys Leu Ser Gly Gly Asp Ala Lys Thr Ala Gly Arg Leu Tyr Lys 
        35                  40                  45              


Gln Gly Lys Met Glu Ala Ala Arg Glu Trp Leu Leu Lys Gly Ala Arg 
    50                  55                  60                  


Asp Asp Val Pro Pro Asn Phe Gln Pro Pro Ala Lys Cys Leu Val Val 
65                  70                  75                  80  


Ala Val Ser His Pro Phe Glu Glu Trp Asp Ile Ser Lys Thr Asn His 
                85                  90                  95      


Asp Val Gln Ala Tyr Ile Tyr Ala Gln Pro Leu Gln Ala Glu Gly His 
            100                 105                 110         


Leu Asn Gly Leu Ser Glu Lys Trp Glu Asp Thr Ser Ala Asp Gln His 
        115                 120                 125             


Lys Leu Trp Phe Glu Lys Thr Gly Val Pro Asp Arg Gly Leu Pro Val 
    130                 135                 140                 


Gln Ala Ile Asn Lys Ile Ala Lys Ala Ala Val Asn Arg Ala Phe Gly 
145                 150                 155                 160 


Val Val Arg Lys Val Glu Asn Arg Asn Glu Lys Arg Arg Ser Arg Asp 
                165                 170                 175     


Asn Arg Ile Ala Glu His Asn Arg Glu Asn Gly Leu Thr Glu Val Val 
            180                 185                 190         


Arg Glu Ala Pro Glu Val Ala Thr Asn Ala Asp Gly Phe Leu Leu His 
        195                 200                 205             


Pro Pro Gly Ile Asp Pro Ser Ile Leu Ser Tyr Ala Ser Val Ser Pro 
    210                 215                 220                 


Val Pro Tyr Asn Ser Ser Lys His Ser Phe Val Arg Leu Pro Glu Glu 
225                 230                 235                 240 


Tyr Gln Ala Tyr Asn Val Glu Pro Asp Ala Pro Ile Pro Gln Phe Val 
                245                 250                 255     


Val Glu Asp Arg Phe Ala Ile Pro Pro Gly Gln Pro Gly Tyr Val Pro 
            260                 265                 270         


Glu Trp Gln Arg Leu Lys Cys Ser Thr Asn Lys His Arg Arg Met Arg 
        275                 280                 285             


Gln Trp Ser Asn Gln Asp Tyr Lys Pro Lys Ala Gly Arg Arg Ala Lys 
    290                 295                 300                 


Pro Leu Glu Phe Gln Ala His Leu Thr Arg Glu Arg Ala Lys Gly Ala 
305                 310                 315                 320 


Leu Leu Val Val Met Arg Ile Lys Glu Asp Trp Val Val Phe Asp Val 
                325                 330                 335     


Arg Gly Leu Leu Arg Asn Val Glu Trp Arg Lys Val Leu Ser Glu Glu 
            340                 345                 350         


Ala Arg Glu Lys Leu Thr Leu Lys Gly Leu Leu Asp Leu Phe Thr Gly 
        355                 360                 365             


Asp Pro Val Ile Asp Thr Lys Arg Gly Ile Val Thr Phe Leu Tyr Lys 
    370                 375                 380                 


Ala Glu Ile Thr Lys Ile Leu Ser Lys Arg Thr Val Lys Thr Lys Asn 
385                 390                 395                 400 


Ala Arg Asp Leu Leu Leu Arg Leu Thr Glu Pro Gly Glu Asp Gly Leu 
                405                 410                 415     


Arg Arg Glu Val Gly Leu Val Ala Val Asp Leu Gly Gln Thr His Pro 
            420                 425                 430         


Ile Ala Ala Ala Ile Tyr Arg Ile Gly Arg Thr Ser Ala Gly Ala Leu 
        435                 440                 445             


Glu Ser Thr Val Leu His Arg Gln Gly Leu Arg Glu Asp Gln Lys Glu 
    450                 455                 460                 


Lys Leu Lys Glu Tyr Arg Lys Arg His Thr Ala Leu Asp Ser Arg Leu 
465                 470                 475                 480 


Arg Lys Glu Ala Phe Glu Thr Leu Ser Val Glu Gln Gln Lys Glu Ile 
                485                 490                 495     


Val Thr Val Ser Gly Ser Gly Ala Gln Ile Thr Lys Asp Lys Val Cys 
            500                 505                 510         


Asn Tyr Leu Gly Val Asp Pro Ser Thr Leu Pro Trp Glu Lys Met Gly 
        515                 520                 525             


Ser Tyr Thr His Phe Ile Ser Asp Asp Phe Leu Arg Arg Gly Gly Asp 
    530                 535                 540                 


Pro Asn Ile Val His Phe Asp Arg Gln Pro Lys Lys Gly Lys Val Ser 
545                 550                 555                 560 


Lys Lys Ser Gln Arg Ile Lys Arg Ser Asp Ser Gln Trp Val Gly Arg 
                565                 570                 575     


Met Arg Pro Arg Leu Ser Gln Glu Thr Ala Lys Ala Arg Met Glu Ala 
            580                 585                 590         


Asp Trp Ala Ala Gln Asn Glu Asn Glu Glu Tyr Lys Arg Leu Ala Arg 
        595                 600                 605             


Ser Lys Gln Glu Leu Ala Arg Trp Cys Val Asn Thr Leu Leu Gln Asn 
    610                 615                 620                 


Thr Arg Cys Ile Thr Gln Cys Asp Glu Ile Val Val Val Ile Glu Asp 
625                 630                 635                 640 


Leu Asn Val Lys Ser Leu His Gly Lys Gly Ala Arg Glu Pro Gly Trp 
                645                 650                 655     


Asp Asn Phe Phe Thr Pro Lys Thr Glu Asn Arg Trp Phe Ile Gln Ile 
            660                 665                 670         


Leu His Lys Thr Phe Ser Glu Leu Pro Lys His Arg Gly Glu His Val 
        675                 680                 685             


Ile Glu Gly Cys Pro Leu Arg Thr Ser Ile Thr Cys Pro Ala Cys Ser 
    690                 695                 700                 


Tyr Cys Asp Lys Asn Ser Arg Asn Gly Glu Lys Phe Val Cys Val Ala 
705                 710                 715                 720 


Cys Gly Ala Thr Phe His Ala Asp Phe Glu Val Ala Thr Tyr Asn Leu 
                725                 730                 735     


Val Arg Leu Ala Thr Thr Gly Met Pro Met Pro Lys Ser Leu Glu Arg 
            740                 745                 750         


Gln Gly Gly Gly Glu Lys Ala Gly Gly Ala Arg Lys Ala Arg Lys Lys 
        755                 760                 765             


Ala Lys Gln Val Glu Lys Ile Val Val Gln Ala Asn Ala Asn Val Thr 
    770                 775                 780                 


Met Asn Gly Ala Ser Leu His Ser Pro 
785                 790             


<210>  10
<211>  812
<212>  PRT
<213>  Biggiephage

<400>  10

Met Asp Met Leu Asp Thr Glu Thr Asn Tyr Ala Thr Glu Thr Pro Ala 
1               5                   10                  15      


Gln Gln Gln Asp Tyr Ser Pro Lys Pro Pro Lys Lys Ala Gln Arg Ala 
            20                  25                  30          


Pro Lys Gly Phe Ser Lys Lys Ala Arg Pro Glu Lys Lys Pro Pro Lys 
        35                  40                  45              


Pro Ile Thr Leu Phe Thr Gln Lys His Phe Ser Gly Val Arg Phe Leu 
    50                  55                  60                  


Lys Arg Val Ile Arg Asp Ala Ser Lys Ile Leu Lys Leu Ser Glu Ser 
65                  70                  75                  80  


Arg Thr Ile Thr Phe Leu Glu Gln Ala Ile Glu Arg Asp Gly Ser Ala 
                85                  90                  95      


Pro Pro Asp Val Thr Pro Pro Val His Asn Thr Ile Met Ala Val Thr 
            100                 105                 110         


Arg Pro Phe Glu Glu Trp Pro Glu Val Ile Leu Ser Lys Ala Leu Gln 
        115                 120                 125             


Lys His Cys Tyr Ala Leu Thr Lys Lys Ile Lys Ile Lys Thr Trp Pro 
    130                 135                 140                 


Lys Lys Gly Pro Gly Lys Lys Cys Leu Ala Ala Trp Ser Ala Arg Thr 
145                 150                 155                 160 


Lys Ile Pro Leu Ile Pro Gly Gln Val Gln Ala Thr Asn Gly Leu Phe 
                165                 170                 175     


Asp Arg Ile Gly Ser Ile Tyr Asp Gly Val Glu Lys Lys Val Thr Asn 
            180                 185                 190         


Arg Asn Ala Asn Lys Lys Leu Glu Tyr Asp Glu Ala Ile Lys Glu Gly 
        195                 200                 205             


Arg Asn Pro Ala Val Pro Glu Tyr Glu Thr Ala Tyr Asn Ile Asp Gly 
    210                 215                 220                 


Thr Leu Ile Asn Lys Pro Gly Tyr Asn Pro Asn Leu Tyr Ile Thr Gln 
225                 230                 235                 240 


Ser Arg Thr Pro Arg Leu Ile Thr Glu Ala Asp Arg Pro Leu Val Glu 
                245                 250                 255     


Lys Ile Leu Trp Gln Met Val Glu Lys Lys Thr Gln Ser Arg Asn Gln 
            260                 265                 270         


Ala Arg Arg Ala Arg Leu Glu Lys Ala Ala His Leu Gln Gly Leu Pro 
        275                 280                 285             


Val Pro Lys Phe Val Pro Glu Lys Val Asp Arg Ser Gln Lys Ile Glu 
    290                 295                 300                 


Ile Arg Ile Ile Asp Pro Leu Asp Lys Ile Glu Pro Tyr Met Pro Gln 
305                 310                 315                 320 


Asp Arg Met Ala Ile Lys Ala Ser Gln Asp Gly His Val Pro Tyr Trp 
                325                 330                 335     


Gln Arg Pro Phe Leu Ser Lys Arg Arg Asn Arg Arg Val Arg Ala Gly 
            340                 345                 350         


Trp Gly Lys Gln Val Ser Ser Ile Gln Ala Trp Leu Thr Gly Ala Leu 
        355                 360                 365             


Leu Val Ile Val Arg Leu Gly Asn Glu Ala Phe Leu Ala Asp Ile Arg 
    370                 375                 380                 


Gly Ala Leu Arg Asn Ala Gln Trp Arg Lys Leu Leu Lys Pro Asp Ala 
385                 390                 395                 400 


Thr Tyr Gln Ser Leu Phe Asn Leu Phe Thr Gly Asp Pro Val Val Asn 
                405                 410                 415     


Thr Arg Thr Asn His Leu Thr Met Ala Tyr Arg Glu Gly Val Val Asn 
            420                 425                 430         


Ile Val Lys Ser Arg Ser Phe Lys Gly Arg Gln Thr Arg Glu His Leu 
        435                 440                 445             


Leu Thr Leu Leu Gly Gln Gly Lys Thr Val Ala Gly Val Ser Phe Asp 
    450                 455                 460                 


Leu Gly Gln Lys His Ala Ala Gly Leu Leu Ala Ala His Phe Gly Leu 
465                 470                 475                 480 


Gly Glu Asp Gly Asn Pro Val Phe Thr Pro Ile Gln Ala Cys Phe Leu 
                485                 490                 495     


Pro Gln Arg Tyr Leu Asp Ser Leu Thr Asn Tyr Arg Asn Arg Tyr Asp 
            500                 505                 510         


Ala Leu Thr Leu Asp Met Arg Arg Gln Ser Leu Leu Ala Leu Thr Pro 
        515                 520                 525             


Ala Gln Gln Gln Glu Phe Ala Asp Ala Gln Arg Asp Pro Gly Gly Gln 
    530                 535                 540                 


Ala Lys Arg Ala Cys Cys Leu Lys Leu Asn Leu Asn Pro Asp Glu Ile 
545                 550                 555                 560 


Arg Trp Asp Leu Val Ser Gly Ile Ser Thr Met Ile Ser Asp Leu Tyr 
                565                 570                 575     


Ile Glu Arg Gly Gly Asp Pro Arg Asp Val His Gln Gln Val Glu Thr 
            580                 585                 590         


Lys Pro Lys Gly Lys Arg Lys Ser Glu Ile Arg Ile Leu Lys Ile Arg 
        595                 600                 605             


Asp Gly Lys Trp Ala Tyr Asp Phe Arg Pro Lys Ile Ala Asp Glu Thr 
    610                 615                 620                 


Arg Lys Ala Gln Arg Glu Gln Leu Trp Lys Leu Gln Lys Ala Ser Ser 
625                 630                 635                 640 


Glu Phe Glu Arg Leu Ser Arg Tyr Lys Ile Asn Ile Ala Arg Ala Ile 
                645                 650                 655     


Ala Asn Trp Ala Leu Gln Trp Gly Arg Glu Leu Ser Gly Cys Asp Ile 
            660                 665                 670         


Val Ile Pro Val Leu Glu Asp Leu Asn Val Gly Ser Lys Phe Phe Asp 
        675                 680                 685             


Gly Lys Gly Lys Trp Leu Leu Gly Trp Asp Asn Arg Phe Thr Pro Lys 
    690                 695                 700                 


Lys Glu Asn Arg Trp Phe Ile Lys Val Leu His Lys Ala Val Ala Glu 
705                 710                 715                 720 


Leu Ala Pro His Arg Gly Val Pro Val Tyr Glu Val Met Pro His Arg 
                725                 730                 735     


Thr Ser Met Thr Cys Pro Ala Cys His Tyr Cys His Pro Thr Asn Arg 
            740                 745                 750         


Glu Gly Asp Arg Phe Glu Cys Gln Ser Cys His Val Val Lys Asn Thr 
        755                 760                 765             


Asp Arg Asp Val Ala Pro Tyr Asn Ile Leu Arg Val Ala Val Glu Gly 
    770                 775                 780                 


Lys Thr Leu Asp Arg Trp Gln Ala Glu Lys Lys Pro Gln Ala Glu Pro 
785                 790                 795                 800 


Asp Arg Pro Met Ile Leu Ile Asp Asn Gln Glu Ser 
                805                 810         


<210>  11
<211>  2121
<212>  DNA
<213>  Artificial

<220>
<223>  Bacteria optimized


<220>
<221>  misc_feature
<222>  (1)..(2121)
<223>  cas_phi-1

<400>  11
atggcggata ccccgaccct gtttacccag tttctgcgcc atcatctgcc gggccagcgc       60

tttcgcaaag atattctgaa acaggcgggc cgcattctgg cgaacaaagg cgaagatgcg      120

accattgcgt ttctgcgcgg caaaagcgaa gaaagcccgc cggattttca gccgccggtg      180

aaatgcccga ttattgcgtg cagccgcccg ctgaccgaat ggccgattta tcaggcgagc      240

gtggcgattc agggctatgt gtatggccag agcctggcgg aatttgaagc gagcgatccg      300

ggctgcagca aagatggcct gctgggctgg tttgataaaa ccggcgtgtg caccgattat      360

tttagcgtgc agggcctgaa cctgattttt cagaacgcgc gcaaacgcta tattggcgtg      420

cagaccaaag tgaccaaccg caacgaaaaa cgccataaaa aactgaaacg cattaacgcg      480

aaacgcattg cggaaggcct gccggaactg accagcgatg aaccggaaag cgcgctggat      540

gaaaccggcc atctgattga tccgccgggc ctgaacacca acatttattg ctatcagcag      600

gtgagcccga aaccgctggc gctgagcgaa gtgaaccagc tgccgaccgc gtatgcgggc      660

tatagcacca gcggcgatga tccgattcag ccgatggtga ccaaagatcg cctgagcatt      720

agcaaaggcc agccgggcta tattccggaa catcagcgcg cgctgctgag ccagaaaaaa      780

catcgccgca tgcgcggcta tggcctgaaa gcgcgcgcgc tgctggtgat tgtgcgcatt      840

caggatgatt gggcggtgat tgatctgcgc agcctgctgc gcaacgcgta ttggcgccgc      900

attgtgcaga ccaaagaacc gagcaccatt accaaactgc tgaaactggt gaccggcgat      960

ccggtgctgg atgcgacccg catggtggcg acctttacct ataaaccggg cattgtgcag     1020

gtgcgcagcg cgaaatgcct gaaaaacaaa cagggcagca aactgtttag cgaacgctat     1080

ctgaacgaaa ccgtgagcgt gaccagcatt gatctgggca gcaacaacct ggtggcggtg     1140

gcgacctatc gcctggtgaa cggcaacacc ccggaactgc tgcagcgctt taccctgccg     1200

agccatctgg tgaaagattt tgaacgctat aaacaggcgc atgataccct ggaagatagc     1260

attcagaaaa ccgcggtggc gagcctgccg cagggccagc agaccgaaat tcgcatgtgg     1320

agcatgtatg gctttcgcga agcgcaggaa cgcgtgtgcc aggaactggg cctggcggat     1380

ggcagcattc cgtggaacgt gatgaccgcg accagcacca ttctgaccga tctgtttctg     1440

gcgcgcggcg gcgatccgaa aaaatgcatg tttaccagcg aaccgaaaaa aaaaaaaaac     1500

agcaaacagg tgctgtataa aattcgcgat cgcgcgtggg cgaaaatgta tcgcaccctg     1560

ctgagcaaag aaacccgcga agcgtggaac aaagcgctgt ggggcctgaa acgcggcagc     1620

ccggattatg cgcgcctgag caaacgcaaa gaagaactgg cgcgccgctg cgtgaactat     1680

accattagca ccgcggaaaa acgcgcgcag tgcggccgca ccattgtggc gctggaagat     1740

ctgaacattg gcttttttca tggccgcggc aaacaggaac cgggctgggt gggcctgttt     1800

acccgcaaaa aagaaaaccg ctggctgatg caggcgctgc ataaagcgtt tctggaactg     1860

gcgcatcatc gcggctatca tgtgattgaa gtgaacccgg cgtataccag ccagacctgc     1920

ccggtgtgcc gccattgcga tccggataac cgcgatcagc ataaccgcga agcgtttcat     1980

tgcattggct gcggctttcg cggcaacgcg gatctggatg tggcgaccca taacattgcg     2040

atggtggcga ttaccggcga aagcctgaaa cgcgcgcgcg gcagcgtggc gagcaaaacc     2100

ccgcagccgc tggcggcgga a                                               2121


<210>  12
<211>  2271
<212>  DNA
<213>  Artificial

<220>
<223>  Bacteria optimized


<220>
<221>  misc_feature
<222>  (1)..(2271)
<223>  cas_phi-2

<400>  12
atgccgaaac cggcggtgga aagcgaattt agcaaagtgc tgaaaaaaca ttttccgggc       60

gaacgctttc gcagcagcta tatgaaacgc ggcggcaaaa ttctggcggc gcagggcgaa      120

gaagcggtgg tggcgtatct gcagggcaaa agcgaagaag aaccgccgaa ctttcagccg      180

ccggcgaaat gccatgtggt gaccaaaagc cgcgattttg cggaatggcc gattatgaaa      240

gcgagcgaag cgattcagcg ctatatttat gcgctgagca ccaccgaacg cgcggcgtgc      300

aaaccgggca aaagcagcga aagccatgcg gcgtggtttg cggcgaccgg cgtgagcaac      360

catggctata gccatgtgca gggcctgaac ctgatttttg atcataccct gggccgctat      420

gatggcgtgc tgaaaaaagt gcagctgcgc aacgaaaaag cgcgcgcgcg cctggaaagc      480

attaacgcga gccgcgcgga tgaaggcctg ccggaaatta aagcggaaga agaagaagtg      540

gcgaccaacg aaaccggcca tctgctgcag ccgccgggca ttaacccgag cttttatgtg      600

tatcagacca ttagcccgca ggcgtatcgc ccgcgcgatg aaattgtgct gccgccggaa      660

tatgcgggct atgtgcgcga tccgaacgcg ccgattccgc tgggcgtggt gcgcaaccgc      720

tgcgatattc agaaaggctg cccgggctat attccggaat ggcagcgcga agcgggcacc      780

gcgattagcc cgaaaaccgg caaagcggtg accgtgccgg gcctgagccc gaaaaaaaac      840

aaacgcatgc gccgctattg gcgcagcgaa aaagaaaaag cgcaggatgc gctgctggtg      900

accgtgcgca ttggcaccga ttgggtggtg attgatgtgc gcggcctgct gcgcaacgcg      960

cgctggcgca ccattgcgcc gaaagatatt agcctgaacg cgctgctgga tctgtttacc     1020

ggcgatccgg tgattgatgt gcgccgcaac attgtgacct ttacctatac cctggatgcg     1080

tgcggcacct atgcgcgcaa atggaccctg aaaggcaaac agaccaaagc gaccctggat     1140

aaactgaccg cgacccagac cgtggcgctg gtggcgattg atctgggcca gaccaacccg     1200

attagcgcgg gcattagccg cgtgacccag gaaaacggcg cgctgcagtg cgaaccgctg     1260

gatcgcttta ccctgccgga tgatctgctg aaagatatta gcgcgtatcg cattgcgtgg     1320

gatcgcaacg aagaagaact gcgcgcgcgc agcgtggaag cgctgccgga agcgcagcag     1380

gcggaagtgc gcgcgctgga tggcgtgagc aaagaaaccg cgcgcaccca gctgtgcgcg     1440

gattttggcc tggatccgaa acgcctgccg tgggataaaa tgagcagcaa caccaccttt     1500

attagcgaag cgctgctgag caacagcgtg agccgcgatc aggtgttttt taccccggcg     1560

ccgaaaaaag gcgcgaaaaa aaaagcgccg gtggaagtga tgcgcaaaga tcgcacctgg     1620

gcgcgcgcgt ataaaccgcg cctgagcgtg gaagcgcaga aactgaaaaa cgaagcgctg     1680

tgggcgctga aacgcaccag cccggaatat ctgaaactga gccgccgcaa agaagaactg     1740

tgccgccgca gcattaacta tgtgattgaa aaaacccgcc gccgcaccca gtgccagatt     1800

gtgattccgg tgattgaaga tctgaacgtg cgcttttttc atggcagcgg caaacgcctg     1860

ccgggctggg ataacttttt taccgcgaaa aaagaaaacc gctggtttat tcagggcctg     1920

cataaagcgt ttagcgatct gcgcacccat cgcagctttt atgtgtttga agtgcgcccg     1980

gaacgcacca gcattacctg cccgaaatgc ggccattgcg aagtgggcaa ccgcgatggc     2040

gaagcgtttc agtgcctgag ctgcggcaaa acctgcaacg cggatctgga tgtggcgacc     2100

cataacctga cccaggtggc gctgaccggc aaaaccatgc cgaaacgcga agaaccgcgc     2160

gatgcgcagg gcaccgcgcc ggcgcgcaaa accaaaaaag cgagcaaaag caaagcgccg     2220

ccggcggaac gcgaagatca gaccccggcg caggaaccga gccagaccag c              2271


<210>  13
<211>  2298
<212>  DNA
<213>  Artificial

<220>
<223>  Bacteria optimized


<220>
<221>  misc_feature
<222>  (1)..(2298)
<223>  cas_phi-3

<400>  13
atggaaaaag aaattaccga actgaccaaa attcgccgcg aatttccgaa caaaaaattt       60

agcagcaccg atatgaaaaa agcgggcaaa ctgctgaaag cggaaggccc ggatgcggtg      120

cgcgattttc tgaacagctg ccaggaaatt attggcgatt ttaaaccgcc ggtgaaaacc      180

aacattgtga gcattagccg cccgtttgaa gaatggccgg tgagcatggt gggccgcgcg      240

attcaggaat attattttag cctgaccaaa gaagaactgg aaagcgtgca tccgggcacc      300

agcagcgaag atcataaaag cttttttaac attaccggcc tgagcaacta taactatacc      360

agcgtgcagg gcctgaacct gatttttaaa aacgcgaaag cgatttatga tggcaccctg      420

gtgaaagcga acaacaaaaa caaaaaactg gaaaaaaaat ttaacgaaat taaccataaa      480

cgcagcctgg aaggcctgcc gattattacc ccggattttg aagaaccgtt tgatgaaaac      540

ggccatctga acaacccgcc gggcattaac cgcaacattt atggctatca gggctgcgcg      600

gcgaaagtgt ttgtgccgag caaacataaa atggtgagcc tgccgaaaga atatgaaggc      660

tataaccgcg atccgaacct gagcctggcg ggctttcgca accgcctgga aattccggaa      720

ggcgaaccgg gccatgtgcc gtggtttcag cgcatggata ttccggaagg ccagattggc      780

catgtgaaca aaattcagcg ctttaacttt gtgcatggca aaaacagcgg caaagtgaaa      840

tttagcgata aaaccggccg cgtgaaacgc tatcatcata gcaaatataa agatgcgacc      900

aaaccgtata aatttctgga agaaagcaaa aaagtgagcg cgctggatag cattctggcg      960

attattacca ttggcgatga ttgggtggtg tttgatattc gcggcctgta tcgcaacgtg     1020

ttttatcgcg aactggcgca gaaaggcctg accgcggtgc agctgctgga tctgtttacc     1080

ggcgatccgg tgattgatcc gaaaaaaggc gtggtgacct ttagctataa agaaggcgtg     1140

gtgccggtgt ttagccagaa aattgtgccg cgctttaaaa gccgcgatac cctggaaaaa     1200

ctgaccagcc agggcccggt ggcgctgctg agcgtggatc tgggccagaa cgaaccggtg     1260

gcggcgcgcg tgtgcagcct gaaaaacatt aacgataaaa ttaccctgga taacagctgc     1320

cgcattagct ttctggatga ttataaaaaa cagattaaag attatcgcga tagcctggat     1380

gaactggaaa ttaaaattcg cctggaagcg attaacagcc tggaaaccaa ccagcaggtg     1440

gaaattcgcg atctggatgt gtttagcgcg gatcgcgcga aagcgaacac cgtggatatg     1500

tttgatattg atccgaacct gattagctgg gatagcatga gcgatgcgcg cgtgagcacc     1560

cagattagcg atctgtatct gaaaaacggc ggcgatgaaa gccgcgtgta ttttgaaatt     1620

aacaacaaac gcattaaacg cagcgattat aacattagcc agctggtgcg cccgaaactg     1680

agcgatagca cccgcaaaaa cctgaacgat agcatttgga aactgaaacg caccagcgaa     1740

gaatatctga aactgagcaa acgcaaactg gaactgagcc gcgcggtggt gaactatacc     1800

attcgccaga gcaaactgct gagcggcatt aacgatattg tgattattct ggaagatctg     1860

gatgtgaaaa aaaaatttaa cggccgcggc attcgcgata ttggctggga taactttttt     1920

agcagccgca aagaaaaccg ctggtttatt ccggcgtttc ataaagcgtt tagcgaactg     1980

agcagcaacc gcggcctgtg cgtgattgaa gtgaacccgg cgtggaccag cgcgacctgc     2040

ccggattgcg gcttttgcag caaagaaaac cgcgatggca ttaactttac ctgccgcaaa     2100

tgcggcgtga gctatcatgc ggatattgat gtggcgaccc tgaacattgc gcgcgtggcg     2160

gtgctgggca aaccgatgag cggcccggcg gatcgcgaac gcctgggcga taccaaaaaa     2220

ccgcgcgtgg cgcgcagccg caaaaccatg aaacgcaaag atattagcaa cagcaccgtg     2280

gaagcgatgg tgaccgcg                                                   2298


<210>  14
<211>  2298
<212>  DNA
<213>  Artificial

<220>
<223>  Bacteria optimized


<220>
<221>  misc_feature
<222>  (1)..(2298)
<223>  cas_phi-4

<400>  14
atgtattcgc tggagatggc agatttaaaa tcggaacctt cgctgttggc aaagctgctg       60

cgcgaccgct tccctggcaa gtactggctt ccaaaatatt ggaaattagc ggaaaagaag      120

cgcctgacgg gcggggaaga agctgcctgt gaatatatgg cagacaaaca attggactcc      180

cccccaccca attttcgtcc gcctgctcgt tgtgtcattt tagcaaaatc gcgcccgttc      240

gaggactggc ccgtccaccg tgtcgcgtca aaggcacaga gcttcgtaat tgggttgtct      300

gaacaggggt tcgcggcact gcgtgctgct ccaccctcaa cagcggacgc tcgccgtgac      360

tggttacgct cacatggggc gagcgaggac gacttaatgg ccttggaggc tcaacttctg      420

gagacaatca tgggaaatgc gatttctctt cacggcggcg tattgaagaa aatcgacaac      480

gcaaatgtta aagctgccaa acgcttaagt ggccgtaacg aggcgcgcct taataagggt      540

ttgcaagaac ttccccccga acaggaggga agtgcctatg gagcagacgg tttattagtg      600

aaccccccgg gccttaatct taatatctat tgccgcaagt cgtgttgtcc aaagcctgta      660

aaaaacactg cacgtttcgt cggtcattac cccggttatt tacgcgactc agattccatc      720

cttatcagtg gtactatgga tcgcctgact atcatcgaag gtatgccggg tcatattccg      780

gcctggcagc gcgaacaagg cttagtaaag cctggaggac gccgtcgtcg cctgagcgga      840

tcggagtcga acatgcgcca gaaggtcgat ccgagcacag ggccacgccg ctcaacccgt      900

tcgggcaccg ttaaccgctc gaatcagcgc actggtcgca atggggaccc gctgttagtt      960

gaaattcgta tgaaggaaga ctgggtctta ttagacgcgc gcggtctgtt acgtaacttg     1020

cgttggcgcg aaagtaagcg tggcctttcc tgcgatcatg aggacctgtc gttgagtggc     1080

ttattagccc ttttctctgg tgatccggta attgatcccg tacgcaacga ggtcgtgttc     1140

ttgtacgggg agggcattat cccggtccgc tccacaaaac ccgttggaac ccgccagtcc     1200

aagaaactgc tggagcgcca ggcctcaatg ggcccattaa cattaatctc atgtgacttg     1260

gggcagacta atcttattgc tggccgcgct agcgcaattt cgctgaccca cgggagcctg     1320

ggcgttcgtt cgtcggttcg catcgagttg gatcctgaga tcatcaaatc ctttgaacgc     1380

ctgcgcaagg acgccgaccg cttagagacc gaaatcttaa ctgcagccaa agaaacttta     1440

agcgatgaac aacgtggaga ggtgaacagt catgaaaaag atagccccca aaccgctaag     1500

gcgagcttgt gccgtgaact tggcttacat ccgccaagtc ttccgtgggg acagatggga     1560

ccaagcacca ccttcatcgc cgatatgttg atctcacatg gccgcgacga cgatgccttt     1620

ttgtcccacg gggagttccc cactcttgaa aaacgtaaaa aattcgacaa acgtttttgt     1680

ctggaaagtc gtccattgtt aagtagtgaa acccgtaagg cccttaatga atcgttgtgg     1740

gaggtaaagc gcacttcgtc ggagtatgcc cgtctgtctc aacgcaaaaa agaaatggct     1800

cgccgcgctg taaacttcgt agtagagatt agtcgtcgta agactggtct tagtaacgtt     1860

attgttaaca ttgaagatct taacgtacgt atctttcatg gaggcggaaa gcaagctccg     1920

ggttgggatg gcttcttccg ccccaagtcg gaaaatcgtt ggttcatcca agctatccat     1980

aaggctttct ccgacttagc tgcccaccat ggtattccag tgatcgagag cgatccgcag     2040

cgcacatcga tgacctgtcc tgaatgtggt cactgtgatt ctaaaaatcg caacggtgtc     2100

cgcttccttt gtaagggctg tggggcttct atggacgcag attttgacgc agcctgtcgt     2160

aacttagaac gtgtggcact gacagggaaa cctatgccca agccgtcaac ctcatgtgag     2220

cgcttgttaa gcgcaacgac cgggaaggtt tgttcggacc actcattgtc gcatgacgcg     2280

attgaaaagg catcataa                                                   2298


<210>  15
<211>  2382
<212>  DNA
<213>  Artificial

<220>
<223>  Bacteria optimized


<220>
<221>  misc_feature
<222>  (1)..(2382)
<223>  cas_phi-5

<400>  15
atgagttctc ttccgacacc tctggaactg ttgaaacaga agcatgcgga cttgttcaaa       60

ggtttacagt tttcatctaa agacaataaa atggccggga aggtactgaa gaaagacggc      120

gaggaggccg cgttggcctt cctgtcggaa cgtggtgtaa gtcgcggcga actgcctaac      180

ttccgtccgc cggcaaaaac gttggtagtt gcccaatctc gtccatttga ggaattcccg      240

atctatcgtg tatcagaggc aattcagctt tacgtctact cattgagcgt aaaagaactg      300

gaaaccgtgc ccagtggcag ttcgaccaag aaagagcatc agcgcttttt ccaggactct      360

tccgtacctg atttcgggta cacgtccgtc caaggactta ataagatctt tgggctggcc      420

cgcggtattt acttgggggt tatcacacgc ggcgaaaatc aattacagaa ggctaaatct      480

aaacatgaag cactgaataa gaagcgccgt gcctccggcg aagccgagac tgagttcgac      540

ccaacgcctt acgaatatat gacgcctgag cgtaaattgg ccaaaccgcc cggagtcaat      600

cacagtatta tgtgttatgt tgatatttct gttgatgaat tcgatttccg taatccggac      660

ggaatcgttt tgccctcgga atacgccggt tactgtcgcg agatcaatac cgcgatcgaa      720

aaggggaccg tcgatcgtct tggccattta aaaggcggac ccggttatat tccaggccac      780

caacgtaagg agagcactac cgaagggcct aagatcaact tccgtaaggg acgtattcgc      840

cgctcgtata cagcgttgta tgccaagcgt gacagtcgcc gtgttcgtca gggtaagctt      900

gccttgcctt cttaccgtca ccacatgatg cgtttgaact ctaacgcaga atccgcaatt      960

ctggctgtaa ttttctttgg aaaagactgg gtcgtttttg atctgcgtgg gttgttacgc     1020

aatgtacgct ggcgtaattt atttgttgac ggatcgactc cgagtacgct tctgggcatg     1080

tttggagatc ccgtgattga tcccaagcgt ggggtagtcg cgttctgcta taaggaacaa     1140

atcgtgcccg tcgtttcaaa gagcatcaca aagatggtca aggccccgga gttgcttaat     1200

aagttatact tgaagtctga ggaccctctg gtacttgtag cgatcgactt gggtcagact     1260

aatcctgttg gggtaggcgt gtaccgtgtc atgaatgcgt ctttagatta cgaagtcgtc     1320

actcgcttcg cccttgagtc tgaactttta cgcgaaattg aatcttatcg ccaacgtaca     1380

aatgctttcg aggcccagat ccgcgcagaa acgtttgacg caatgacaag tgaggagcag     1440

gaggagatca cgcgcgtccg cgctttcagc gcctctaagg ctaaagagaa cgtatgtcac     1500

cgcttcggaa tgccggtaga cgctgtggac tgggcgacaa tgggttctaa cacgatccac     1560

atcgctaaat gggtgatgcg tcacggtgat cctagtcttg tggaagtact ggaatatcgc     1620

aaagataatg agattaaatt ggataagaac ggagtaccta aaaaggtgaa actgacggac     1680

aaacgtatcg ctaatctgac gtctattcgc cttcgttttt cgcaagaaac atcgaaacac     1740

tacaacgata ccatgtggga acttcgccgt aagcaccccg tctatcagaa gctgtcaaaa     1800

tccaaagctg atttcagccg tcgcgtggtt aactcgatta tccgtcgtgt caaccatctg     1860

gtaccacgcg cacgtatcgt cttcattatc gaggacctta agaatcttgg aaaggtcttt     1920

cacggcagtg ggaagcgcga gttaggctgg gactcatact ttgaaccgaa gtcggagaat     1980

cgctggttca tccaagtttt acataaggct tttagcgaga caggtaagca caaagggtat     2040

tatattatcg agtgctggcc gaactggact agctgcacat gtccgaagtg cagctgctgc     2100

gatagtgaga accgccacgg tgaggtattc cgctgcttag cctgcgggta cacctgcaat     2160

accgactttg ggactgcacc ggataatctt gtcaagattg caacgactgg aaaaggattg     2220

ccaggaccaa agaaacgttg taaaggttcg tccaaaggaa aaaacccgaa gatcgcacgt     2280

tcatcagaga ccggggtttc ggtaaccgag tcgggtgccc ccaaagttaa aaaatcatcc     2340

ccaactcaaa cttcccaatc gtcttcgcag agcgctccat aa                        2382


<210>  16
<211>  1326
<212>  DNA
<213>  Artificial

<220>
<223>  Bacteria optimized


<220>
<221>  misc_feature
<222>  (1)..(1326)
<223>  cas_phi-6

<400>  16
atgaacaaga tcgaaaaaga aaagaccccc ttggctaaat taatgaacga gaactttgcc       60

ggtttgcgtt ttccattcgc tattattaaa caggcaggca agaaactgct taaggagggg      120

gaactgaaaa cgattgagta tatgaccggg aaaggtagca ttgaaccctt gccaaatttc      180

aaaccgccag taaagtgctt gatcgtggct aaacgtcgcg acctgaaata ttttcccatt      240

tgcaaagcgt catgtgagat tcaatcgtat gtctattctc ttaactataa ggatttcatg      300

gactacttct cgacgcctat gacgtcacag aagcagcacg aggagttttt caaaaaaagt      360

ggacttaata tcgaatatca aaatgttgct ggattgaatt tgattttcaa caatgtaaaa      420

aacacctata acggggttat ccttaaagta aaaaaccgca acgaaaaact taaaaagaaa      480

gccattaaaa ataactatga gtttgaggaa attaaaacct tcaatgacga tggatgtctt      540

attaacaagc ctggtattaa caacgtgatt tactgcttcc aatccatcag ccccaagatc      600

ttgaagaaca tcacacattt acccaaggag tacaacgatt atgactgctc tgtcgatcgc      660

aatattatcc aaaagtatgt gagtcgtctt gacatccccg agtcgcaacc cgggcacgtt      720

cccgaatggc agcgtaaatt gcccgagttc aataacacta acaatccacg tcgtcgccgt      780

aaatggtata gtaacgggcg taacatctcg aaagggtatt ccgtcgatca ggttaatcag      840

gccaaaatcg aagacagcct gttggcgcaa atcaaaatcg gagaagactg gattatcttg      900

gatattcgcg gtctgcttcg cgacttgaat cgccgcgagc ttatttctta caagaataaa      960

cttaccatta aagatgtgtt aggtttcttc tccgactacc ctattattga tattaagaaa     1020

aatttagtaa cgttttgcta caaggaagga gtaattcaag tagtatcaca aaagtccatt     1080

ggaaacaaaa aatctaaaca attacttgaa aagttgatcg agaacaagcc gattgctctg     1140

gtttctattg atttgggtca gacaaaccca gtctcggtca agatctctaa attgaataag     1200

atcaacaaca aaatctcaat tgagtcattt acgtaccgct tccttaatga ggagatctta     1260

aaggaaatcg aaaagtatcg taaagattac gataaattgg aattgaagtt gattaacgaa     1320

gcgtaa                                                                1326


<210>  17
<211>  2319
<212>  DNA
<213>  Artificial

<220>
<223>  Bacteria optimized


<220>
<221>  misc_feature
<222>  (1)..(2319)
<223>  cas_phi-7

<400>  17
atgtctaata cagcagtatc aacacgcgag catatgtcta acaaaacaac gccaccgtcg       60

ccgttgagtt tgttattgcg tgcgcatttt ccgggcctta aattcgaatc tcaagactat      120

aagatcgctg ggaaaaagct tcgcgatggg ggcccagaag cggtaatcag ctacttgacc      180

ggtaaaggac aagccaaatt aaaagatgtt aagccacccg caaaagcgtt cgtcattgct      240

caatcacgcc cttttattga atgggattta gtgcgtgtga gtcgccaaat tcaggagaaa      300

attttcggca tccccgcaac taaagggcgt cccaagcaag acggtctttc ggaaacggcg      360

ttcaatgagg ctgtggcgtc attagaggta gatggaaagt cgaagctgaa cgaagaaaca      420

cgtgctgcat tctatgaagt gttgggcctg gatgcaccaa gtctgcatgc acaggcacaa      480

aacgccttga ttaaatcggc aatttctatt cgtgaaggcg tcttaaaaaa agtggaaaat      540

cgtaatgaaa aaaatttatc gaaaaccaag cgtcgtaagg aggcaggtga agaggccacc      600

ttcgtagagg agaaagcgca cgacgaacgc ggctatctta tccaccctcc cggtgttaac      660

cagacgattc ctggatacca ggccgtggtg attaaatctt gcccgagcga ttttatcgga      720

cttcctagcg gctgcctggc gaaggagtcg gccgaggcct taaccgatta cttgcctcac      780

gaccgcatga ccattcccaa gggtcaaccc ggttacgttc ccgaatggca gcatccctta      840

cttaatcgtc gtaagaaccg ccgccgccgt gattggtact cggcttcttt aaataaacca      900

aaagcaacct gctctaagcg cagtggcacg ccgaatcgta aaaatagccg cacagaccaa      960

atccagtcgg ggcgcttcaa gggcgctatc cctgtgctga tgcgttttca ggacgaatgg     1020

gtaattattg acattcgtgg gcttttacgt aacgcacgct atcgtaaatt actgaaggag     1080

aaaagcacaa tcccggattt gttatcgttg ttcactgggg acccctcaat tgatatgcgt     1140

cagggggtat gtaccttcat ctacaaagct gggcaggcgt gctctgctaa gatggtaaaa     1200

acgaaaaatg ctcctgagat cttgtcagag cttacaaaga gcgggccggt tgtgttagtt     1260

tcgatcgatt tgggacaaac taatccgatt gcagcaaagg tgtcgcgtgt tacacaattg     1320

agcgatggtc aacttagcca tgaaacgtta ttacgtgaat tgctgtcaaa cgactcaagt     1380

gatggcaaag aaatcgcccg ctaccgtgtg gcttcagatc gtctgcgtga caaattggcc     1440

aacttggcgg tcgagcgctt aagccccgag cataaatcag agattcttcg tgctaaaaat     1500

gacacaccgg cgttgtgtaa agcccgcgtg tgtgcggccc ttggtttaaa tcccgagatg     1560

atcgcgtggg ataaaatgac cccatatacg gaattcctgg cgacagccta tcttgagaag     1620

ggcggcgacc gtaaggtggc gactttgaag cccaagaacc gcccagaaat gctgcgccgc     1680

gacatcaagt tcaagggtac cgaaggcgtg cgcattgagg tgagtcccga agcagcggaa     1740

gcgtaccgcg aagcccagtg ggacttacag cgtacctctc cagagtacct gcgtcttagt     1800

acatggaaac aagagcttac aaaacgtatc ctgaatcaac tgcgccataa ggcagccaag     1860

tcctcacaat gtgaagtagt ggttatggcg ttcgaagact tgaacattaa aatgatgcac     1920

ggaaacggga aatgggccga tggaggatgg gacgcatttt ttatcaagaa acgtgaaaat     1980

cgttggttca tgcaggcatt ccataaatct ttaaccgagc ttggcgcaca caaaggagtc     2040

cccactatcg aagtgacacc gcaccgcact tcgatcacct gtacaaagtg tgggcattgt     2100

gacaaggcaa atcgtgacgg agagcgcttt gcgtgtcaaa agtgcggctt cgttgctcat     2160

gcagatttag agattgctac agataatatt gagcgtgtgg ctctgacagg gaagcctatg     2220

ccgaaaccgg agtcagaacg ttcgggagac gctaaaaaat ccgtgggtgc ccgcaaagcg     2280

gcgtttaagc cggaagaaga cgctgaggcg gcggaatga                            2319


<210>  18
<211>  2154
<212>  DNA
<213>  Artificial

<220>
<223>  Bacteria optimized


<220>
<221>  misc_feature
<222>  (1)..(2154)
<223>  cas_phi-8

<400>  18
atgattaaac cgacagtgag ccagtttctg acgccgggct ttaagcttat ccgcaaccat       60

tctcgcacgg ccggcctgaa gctgaaaaat gagggagagg aggcctgtaa gaagttcgta      120

cgtgagaacg agattccaaa ggatgaatgt cccaacttcc agggtggccc agctatcgct      180

aacatcatcg caaaatctcg cgaattcaca gaatgggaaa tctaccagtc cagtcttgca      240

attcaggagg tcattttcac attaccaaaa gataagcttc cggagccaat cttgaaggag      300

gaatggcgcg cccaatggtt gtcggaacac ggcctggata ccgtcccgta caaagaagca      360

gctggcttaa atcttatcat caaaaacgcg gtcaacacat ataagggtgt acaggtaaaa      420

gtagacaata agaacaagaa caatttagcc aagattaacc gcaagaatga aatcgccaaa      480

ttaaacggcg aacaggagat ttccttcgaa gaaattaaag ccttcgatga taagggatat      540

ctgcttcaaa agcctagccc caataaatct atctattgtt accaaagtgt ctcacctaaa      600

ccattcatta cgagcaaata tcacaacgta aatcttccgg aagaatatat tggatattat      660

cgcaaaagta atgaaccgat cgtctctccc tatcaatttg atcgcttacg tatccctatc      720

ggcgagcctg gatatgtgcc caagtggcag tatacatttc ttagcaaaaa ggaaaacaag      780

cgtcgcaaat tatcgaagcg catcaaaaat gtctccccga ttttaggcat catttgtatt      840

aaaaaggatt ggtgtgtttt tgacatgcgc ggattattac gtaccaatca ctggaaaaaa      900

taccacaaac ccactgattc cattaacgac ttattcgact atttcacagg cgacccagta      960

attgacacta aggcgaacgt tgtccgtttc cgttataaga tggaaaacgg aattgtaaat     1020

tacaaaccgg ttcgtgagaa gaaaggcaaa gagcttttag aaaatatttg cgatcaaaat     1080

gggtcgtgca agttagccac cgtggacgtg ggtcaaaaca acccggttgc aattggcttg     1140

tttgaattga agaaagtcaa tggtgagctg accaaaactt taatctcacg tcaccccact     1200

ccaatcgact tctgcaataa gattaccgcc taccgcgaac gctatgacaa gttggaatct     1260

agtatcaagt tggacgcgat taagcagctt acttccgaac aaaaaatcga agtcgacaat     1320

tacaacaaca acttcacccc ccagaacacc aagcaaattg tgtgttctaa acttaacatc     1380

aacccgaacg atcttccatg ggacaaaatg attagcggca cacactttat ctcagaaaag     1440

gcccaggtct cgaacaagtc tgaaatctat ttcacgagta ctgataaggg taagacgaag     1500

gatgtgatga agagtgatta caaatggttc caggactaca aacctaaatt atctaaagaa     1560

gtacgtgacg ctctttccga cattgaatgg cgtcttcgcc gcgagtcgct tgagttcaat     1620

aagttatcca agagccgtga gcaggatgcc cgccaattgg ccaactggat ttcgtccatg     1680

tgtgatgtga tcggcattga gaatttggtg aaaaaaaaca atttttttgg aggctctggg     1740

aaacgcgaac ccgggtggga taatttctac aaaccaaaga aggagaatcg ctggtggatc     1800

aacgctatcc ataaagcttt aacagaactt tcccaaaata aaggtaagcg cgtgattctg     1860

cttcccgcta tgcgtacttc aattacttgt cccaagtgta aatactgcga ttccaagaac     1920

cgtaacggag agaagtttaa ctgtttaaaa tgcggtatcg aacttaacgc ggatattgac     1980

gttgctacgg agaacctggc cacggtcgcg attaccgcac agagtatgcc taagccaact     2040

tgcgagcgca gtggcgacgc gaaaaaaccg gtgcgtgcac gtaaggcaaa agctcccgag     2100

ttccacgata aattggcgcc atcttacacc gtggttttgc gtgaagcagt atga           2154


<210>  19
<211>  2382
<212>  DNA
<213>  Artificial

<220>
<223>  Bacteria optimized


<220>
<221>  misc_feature
<222>  (1)..(2382)
<223>  cas_phi-9

<400>  19
atgcgctcca gccgcgagat tggtgacaaa attcttatgc gccagcctgc tgagaagact       60

gctttccagg ttttccgcca agaggttatt gggacccaaa agctttcggg tggagatgcg      120

aagactgcag ggcgtttata caaacagggc aaaatggaag ctgcccgtga atggttactg      180

aagggtgctc gtgacgacgt gccgccaaat tttcagccgc ccgctaaatg cctggttgtt      240

gcggtttccc atccgttcga agagtgggat attagtaaaa cgaaccatga cgtacaggct      300

tatatctacg cgcaaccctt gcaggctgaa ggacacctga acgggttgag tgagaagtgg      360

gaggatactt cagctgacca gcacaagtta tggtttgaga agaccggtgt cccagatcgc      420

ggcttgcccg tgcaagcgat taacaaaatt gctaaggccg cagtaaatcg cgcgtttggt      480

gtcgtacgta aggtcgaaaa ccgtaatgag aaacgtcgtt cacgcgataa tcgcatcgct      540

gaacacaacc gcgaaaatgg gctgactgag gtggttcgcg aggcacctga agtggccacc      600

aacgcagatg ggtttctgtt acacccgcca gggatcgatc ctagcatctt aagctatgcg      660

tcagtatccc cggttcccta taattccagc aaacattcct tcgtccgctt acctgaagaa      720

tatcaggcgt acaatgtcga acccgacgca ccgattccgc agttcgttgt agaagaccgt      780

ttcgcaatcc cgccaggaca acctgggtac gtccccgaat ggcaacgcct taaatgttct      840

actaacaagc atcgccgtat gcgtcaatgg tctaaccaag actataagcc gaaggcgggc      900

cgtcgtgcga aaccgctgga atttcaggcc catttgactc gtgagcgcgc aaagggcgca      960

ctgctggtcg ttatgcgcat taaagaagat tgggtagtat tcgatgtgcg cgggttactt     1020

cgtaacgtgg agtggcgcaa ggtgttgtcc gaggaagctc gtgagaagct gactctgaag     1080

gggttgttgg atctgttcac aggggacccc gttatcgata ccaagcgtgg gatcgttaca     1140

ttcctgtaca aggccgagat cacgaagatt ctgagtaagc gtacagttaa gaccaaaaac     1200

gcccgtgatc ttttgctgcg ccttacagaa ccaggcgaag atgggcttcg tcgcgaggtg     1260

ggattagttg ccgtcgacct gggacagacg catcccatcg cggcagcgat ctaccgtatt     1320

gggcgcactt cggcaggggc cctggagagc acggtcttac atcgtcaagg ccttcgcgag     1380

gaccagaagg aaaaacttaa agaataccgt aaacgccata ccgccttaga cagccgtttg     1440

cgcaaggaag cgttcgaaac gttatcagtc gagcagcaga aagagatcgt caccgtgtct     1500

ggatcgggtg cacaaattac gaaagacaaa gtgtgcaact acttaggggt tgacccttcc     1560

actctgccat gggaaaaaat gggctcttac acacacttta tttcggatga ctttctgcgt     1620

cgtggcggag atccaaatat cgtacacttc gatcgtcaac cgaaaaaggg aaaagtctcc     1680

aaaaaaagtc agcgcattaa acgttcagat tcacagtggg tagggcgcat gcgccctcgc     1740

ctgtcccagg aaactgcgaa agctcgcatg gaggcggact gggcggcaca aaatgagaac     1800

gaggaataca agcgcctggc ccgttcgaag caggaacttg cgcgttggtg tgttaatacg     1860

ttactgcaaa atactcgctg cattactcag tgtgacgaga ttgtcgtggt tatcgaggat     1920

ttgaacgtca aaagtttaca tggtaaggga gcacgcgaac caggctggga taatttcttt     1980

acaccgaaaa cagagaaccg ttggttcatc cagattttgc ataagacctt tagtgaatta     2040

ccaaagcacc gcggggagca cgtaattgaa gggtgtccct tgcgcacttc catcacttgt     2100

ccagcttgtt cttattgtga taagaattcc cgcaatggag agaaattcgt ttgcgtagcg     2160

tgcggggcaa cgttccacgc ggacttcgaa gtggcaacat acaatcttgt gcgtcttgcc     2220

acgaccggga tgcccatgcc caaatcgttg gaacgtcaag gtggtggaga aaaagctgga     2280

ggtgcccgca aggcacgtaa gaaagctaag caagttgaaa agatcgtggt acaggccaat     2340

gctaatgtca ccatgaacgg agcctcgctg cacagtccgt aa                        2382


<210>  20
<211>  2439
<212>  DNA
<213>  Artificial

<220>
<223>  Bacteria optimized


<220>
<221>  misc_feature
<222>  (1)..(2439)
<223>  cas_phi-10

<400>  20
atggatatgc tggatacgga gactaactat gcaaccgaga ctcctgcgca acagcaagat       60

tattctccca aaccgccaaa gaaagctcag cgcgcaccaa aggggtttag caaaaaagcg      120

cgcccagaga aaaaaccgcc taaacccatt acattgttca cccaaaagca tttcagcggg      180

gtccgcttcc ttaaacgcgt tatccgtgat gcttcaaaaa ttttaaagct tagtgaatct      240

cgcaccatta cttttttaga gcaggcgatc gagcgcgatg gtagtgcacc acccgatgtg      300

acaccaccag tacataacac gattatggct gtgacacgtc ctttcgagga atggccagag      360

gtgattttgt ccaaagctct gcagaagcac tgctatgcac tgaccaagaa gattaaaatc      420

aaaacatggc ctaagaaagg tcccggaaaa aaatgcctgg ccgcttggtc cgctcgtacg      480

aaaattccgc ttatccccgg ccaagttcaa gctacaaatg ggttgtttga ccgcatcggg      540

tcaatttatg acggagtcga gaaaaaagtt acaaatcgca acgcaaacaa gaagttagag      600

tatgacgagg caattaaaga gggtcgtaac ccggccgtac ccgagtatga gacggcctat      660

aacatcgatg ggaccctgat taataaacca gggtacaacc cgaatttata tatcacacag      720

tctcgtactc cccgcttaat tactgaagcc gatcgccctc ttgtagaaaa gatcttatgg      780

caaatggtgg aaaagaaaac gcaaagccgt aatcaagcac gccgtgcacg cttagagaag      840

gcggctcatt tgcagggatt gccggtgccc aagttcgttc ccgaaaaggt tgatcgctcc      900

caaaaaattg agatccgcat cattgatcct ttggataaaa ttgagcccta catgccgcaa      960

gaccgcatgg ccatcaaagc aagtcaagac ggccatgtgc cctattggca acgtcccttc     1020

ctgtcgaagc gtcgcaaccg tcgtgtgcgt gcggggtggg gaaaacaagt cagctccatc     1080

caagcgtggt taaccggtgc cttattagta attgtacgcc tgggaaacga agctttttta     1140

gccgacattc gcggggcgct tcgcaatgcc cagtggcgta aactgcttaa gccagacgca     1200

acctatcagt cattatttaa cctgttcaca ggtgaccccg tcgttaacac acgtacgaac     1260

caccttacaa tggcataccg tgaaggcgta gtcaatattg tcaaaagccg ctccttcaag     1320

ggacgtcaaa ctcgcgaaca cttacttaca ctgctgggcc agggcaaaac tgttgctggt     1380

gtttcgttcg atctgggaca aaaacatgcg gcggggttgc ttgccgcaca ttttggcctg     1440

ggcgaagatg gtaatccagt cttcactccc atccaagctt gctttttacc gcagcgttat     1500

cttgacagcc ttactaacta tcgcaaccgc tatgatgccc ttacgctgga catgcgtcgt     1560

cagtctttgt tggccctgac ccctgcacaa caacaagagt tcgcggacgc gcagcgtgat     1620

ccgggcggac aggcaaaacg tgcgtgttgt ttaaagctta atttaaaccc ggacgaaatt     1680

cgctgggacc tggtatcagg gatctctaca atgatctctg atttatacat tgaacgcggt     1740

ggagaccctc gtgacgtaca ccaacaggtg gaaactaaac cgaaaggcaa gcgtaaaagc     1800

gaaatccgca tcctgaagat ccgtgatggt aaatgggcct atgactttcg tcccaagatt     1860

gctgatgaaa ctcgcaaagc acaacgtgaa cagttatgga agcttcaaaa ggcatctagt     1920

gagttcgaac gtctttcccg ctacaaaatt aatatcgctc gcgccattgc aaattgggct     1980

ctgcagtggg gccgcgagtt aagtggctgc gacattgtga tcccggtact tgaagacttg     2040

aatgtcggct ctaagttttt tgacggaaag gggaagtggc ttttaggatg ggataatcgc     2100

tttactccaa aaaaggagaa tcgctggttt attaaagtgc ttcacaaggc ggttgcggag     2160

ctggcacccc accgcggagt accggtctat gaagtcatgc ctcatcgcac atccatgacg     2220

tgtcctgctt gccattactg tcatccgaca aatcgtgagg gcgatcgttt cgaatgccag     2280

agttgtcatg tagttaagaa cactgaccgc gacgtggcgc cctataatat ccttcgcgtc     2340

gcagtagagg gaaagactct tgatcgctgg caagctgaga aaaagccgca agcggagcca     2400

gatcgcccaa tgattttaat tgacaaccag gaatcctga                            2439


<210>  21
<211>  2124
<212>  DNA
<213>  Artificial

<220>
<223>  Human optimized


<220>
<221>  misc_feature
<222>  (1)..(2124)
<223>  cas_phi-1

<400>  21
atggcagata caccaacatt gtttacacaa tttctccgcc accatctgcc ggggcaacga       60

tttagaaagg acatccttaa acaggcggga cgcatccttg ctaataaagg tgaggatgca      120

acaatcgcgt ttttgcgggg aaagagtgag gaatctccac ccgattttca gccccccgtt      180

aaatgcccga taatcgcatg ctcccgcccg ctcacggagt ggccaattta ccaagcatca      240

gttgctatcc aaggttacgt ctatgggcag tccttggccg aatttgaagc cagtgacccc      300

ggatgctcaa aagatggtct gctggggtgg ttcgacaaaa caggcgtttg caccgattac      360

ttctctgttc aggggttgaa tctcattttt cagaacgctc ggaagcggta tatcggtgtg      420

caaacaaagg ttacgaatag aaatgaaaag cggcacaaaa agctgaaacg catcaacgct      480

aagcgaattg cagaaggtct gcccgaattg acgagcgacg aacccgaatc cgcgttggat      540

gagaccgggc acctcattga cccccctggt cttaacacga acatctactg ttaccaacag      600

gtaagcccga agcctctcgc acttagcgag gtcaatcaac tcccgacggc ctacgctgga      660

tactcaacta gcggtgatga cccgatacag ccgatggtga caaaggacag gttgagcatc      720

tcaaagggcc agcctggcta tattccagag catcaaagag cattgctgtc ccaaaagaaa      780

catcgcagaa tgaggggata tggactgaag gctcgcgccc tgttggtgat tgttcgcatt      840

caggatgact gggccgtcat agaccttaga agcttgctca ggaacgccta ctggcgccga      900

attgtccaga ccaaagagcc tagcaccatt acaaaactgt tgaaactggt gacaggtgat      960

ccagtgttgg acgctacgag gatggtagct actttcacct ataagccggg gattgtgcag     1020

gtgcgctccg ccaaatgttt gaaaaataag caaggctcca aactgttctc agagcgctat     1080

cttaatgaga ctgtaagtgt tacatctatt gatttgggat caaataacct tgtcgctgta     1140

gccacttatc gcttggttaa cggaaacact cccgagcttc tgcagaggtt tactctcccg     1200

agtcacctcg tgaaagactt tgaacgatac aaacaggcgc atgatacatt ggaggactcc     1260

atacagaaga ctgcagtggc gagcttgcca cagggccaac aaacggaaat ccgcatgtgg     1320

agtatgtacg gcttccgcga agcccaggaa cgcgtctgtc aggaattggg cttggcagat     1380

ggatcaatcc cttggaacgt tatgactgcg accagcacca tactcacaga tcttttcctt     1440

gctcgcggtg gtgatcccaa aaaatgtatg tttactagtg aacccaagaa gaagaagaat     1500

agcaaacagg ttttgtataa gatacgagac cgagcttggg cgaagatgta taggacattg     1560

ttgagtaagg aaacccggga ggcatggaac aaggcactct ggggtcttaa gaggggctcc     1620

cccgattatg ctaggctctc aaagaggaag gaggaacttg cgagaagatg cgtaaactac     1680

actatcagca ctgctgagaa gcgggcgcag tgcgggagga ccattgtagc gctggaggat     1740

cttaatatcg gatttttcca tgggcggggg aaacaggaac cgggttgggt tggccttttc     1800

accagaaaga aggaaaatcg ctggctcatg caggccttgc ataaggcatt cttggagctg     1860

gctcaccaca gagggtacca tgtcattgaa gtcaatcccg cctatacttc tcagacttgt     1920

cctgtgtgca ggcactgtga tcccgacaac cgagaccagc ataatcgcga ggcctttcat     1980

tgtatcggat gtggtttccg agggaatgca gaccttgacg tggcgaccca caatatagcc     2040

atggttgcca tcacgggaga atctttgaaa cgcgctcgcg gtagcgtggc gtcaaagacc     2100

ccacaaccct tggccgcgga atag                                            2124


<210>  22
<211>  2274
<212>  DNA
<213>  Artificial

<220>
<223>  Human optimized


<220>
<221>  misc_feature
<222>  (1)..(2274)
<223>  cas_phi-2

<400>  22
atgccaaagc cagcagtaga gagtgagttt agtaaagtgc tgaaaaagca cttccccggg       60

gaacggttca gatcaagcta catgaagaga ggaggcaaga tattggcagc ccaaggggag      120

gaagctgtcg tagcttacct ccagggtaaa agcgaagaag agcccccaaa cttccaacct      180

ccggcgaaat gccacgttgt cacaaagtcc agagattttg cggaatggcc catcatgaag      240

gcaagcgaag ctatacagcg gtacatttac gccctgagta ccacagaacg agcggcatgt      300

aagcccggga aaagttctga gtcacacgca gcttggttcg cagcaactgg cgtgtctaat      360

cacggctatt cccacgtgca agggctcaac ttgatctttg accacactct cggccggtac      420

gacggggtac ttaaaaaagt tcagctccgc aatgaaaagg cgagggcgag gctcgagagt      480

ataaatgcta gcagagctga tgagggactg cctgaaataa aggcggaaga ggaggaagtg      540

gctaccaacg aaacaggtca tcttttgcag cctccgggta ttaacccttc cttttatgtc      600

taccagacga tctccccaca agcttatcgc ccaagagatg agattgtatt gccaccagag      660

tatgcgggtt acgtacggga ccctaatgct cctatacctc tcggtgtcgt gcgaaaccgc      720

tgcgacatac aaaaaggctg cccaggctac attccagagt ggcaacggga ggcaggaacg      780

gcaatttctc ctaagacggg taaagctgtg actgtacccg gtctgagccc gaaaaaaaat      840

aagcggatgc ggcgatattg gcgatctgag aaggaaaagg cacaggacgc cctcttggta      900

acagttagga taggtacgga ttgggtcgtt attgatgtac gagggcttct cagaaatgcg      960

agatggagaa cgatagcccc aaaagatata agcctcaacg cgctcttgga cctctttacc     1020

ggtgacccag taatagatgt tcggcgaaac atcgtgacgt ttacttacac tctcgatgca     1080

tgcggtacgt atgcaagaaa gtggactctt aaaggcaagc aaacgaaagc taccctggac     1140

aaactgactg ccactcagac tgtcgccctt gtggcgattg atcttggcca aacgaaccca     1200

atctctgcgg gcataagccg cgtgacgcaa gaaaacggag cactgcagtg cgaaccgctc     1260

gacagattca ctttgccgga tgaccttctt aaggatatat ctgcttacag aatagcttgg     1320

gaccggaacg aggaagaatt gcgagcgcgg agtgtagaag cgctgcccga ggcccagcaa     1380

gctgaggtca gggcactcga tggtgtgagc aaggagaccg ctcgaacgca actttgtgcg     1440

gactttgggc tcgatcctaa acgactcccc tgggataaga tgtcctccaa caccactttt     1500

atctcagaag cactcctctc aaatagtgtc tctcgggacc aggttttttt tacccctgct     1560

ccaaaaaaag gcgctaagaa gaaagcccca gtagaggtca tgcggaaaga ccgaacgtgg     1620

gctagagcct acaaaccccg gcttagtgta gaagcgcaaa agctgaaaaa cgaagctctc     1680

tgggccttga agcggacgtc ccctgaatac ctgaaactca gtcgacggaa agaggagctc     1740

tgtagacgat ccatcaatta tgtgatcgaa aagactcgga ggagaacaca atgtcaaata     1800

gtaatccccg ttattgagga tcttaacgtc aggtttttcc acggtagcgg caagagattg     1860

cctggctggg acaatttttt cacggcaaag aaggaaaatc ggtggttcat acagggtctg     1920

cacaaagcgt tttcagatct ccggacacat agatcctttt acgtctttga agtgcgaccg     1980

gaacgcacaa gtattacttg tccgaaatgc ggccactgcg aggtcggtaa ccgcgacgga     2040

gaggcattcc aatgcttgag ctgtggcaaa acgtgtaacg cggacctcga cgtagccacc     2100

cataacctta cgcaagtggc gttgactggg aagacgatgc ctaaaaggga ggaacctcgc     2160

gacgcgcaag ggactgctcc agcacgaaaa acaaagaaag cttcaaaatc aaaggcgcct     2220

ccggctgagc gggaagatca gacgcccgcg caggaacctt ctcaaacttc ttag           2274


<210>  23
<211>  2301
<212>  DNA
<213>  Artificial

<220>
<223>  Human optimized


<220>
<221>  misc_feature
<222>  (1)..(2301)
<223>  cas_phi-3

<400>  23
atggaaaagg agattacgga actgacgaaa attcgccgcg agttcccaaa caagaaattc       60

agcagcacag acatgaagaa ggctggcaaa ttgcttaaag ctgaaggccc agatgccgtt      120

cgcgattttc ttaacagctg ccaggaaatc attggcgact tcaaaccgcc cgttaagact      180

aatattgtaa gcatctctcg accttttgag gaatggccgg tatctatggt tgggcgagcg      240

attcaggaat actactttag tctcactaaa gaggagctcg aaagcgtgca tccaggtacg      300

tccagcgagg atcacaaaag cttctttaat attacagggc tcagtaacta taattataca      360

tcagttcaag gcctgaatct catttttaag aacgccaaag ccatatatga tggcactctt      420

gtcaaagcta acaacaaaaa caagaaattg gagaaaaaat tcaacgaaat taaccataaa      480

aggtcactgg aaggcctccc tattattaca cctgatttcg aagagccgtt cgatgaaaac      540

ggacacctta acaaccctcc cgggataaac agaaatattt acgggtatca aggttgtgcg      600

gctaaagtct tcgtccctag taagcacaag atggtatccc tccccaaaga atatgagggg      660

tacaatcgag atcctaatct cagtctggca ggcttccgca atagacttga aattccggaa      720

ggggaacctg gacatgtccc ttggttccaa cgcatggata tcccggaggg tcaaataggg      780

cacgtaaaca aaatccagag attcaacttc gtacacggta aaaactccgg aaaggtgaaa      840

ttctccgata agacgggacg ggtcaagcgc taccaccatt ccaaatataa agatgccacc      900

aagccgtata aatttctcga agaatccaag aaggtctcag cgctcgatag tatacttgca      960

ataataacaa ttggcgatga ttgggtagtc tttgatattc gagggctcta ccgaaatgtt     1020

ttttatagag aattggcgca gaaaggtctt acggcagtgc agctcttgga tctctttacg     1080

ggggacccgg taatagaccc gaaaaagggt gtcgtaacct tcagctacaa agaaggtgtc     1140

gtcccggtat tctctcagaa aatagtcccc cgctttaagt caagagatac tctggaaaag     1200

cttacttctc aagggccggt tgcgctcctc agtgtagact tgggacaaaa cgaacctgtt     1260

gcggcgcggg tgtgctcttt gaagaacatt aacgacaaaa taacacttga caattcttgt     1320

cggatttcat tcctggatga ctataagaag cagataaaag actaccgaga ctccttggat     1380

gagctggaaa taaaaattag attggaggct attaattctc ttgagacaaa ccagcaggtg     1440

gagatcagag atctggatgt tttctcagct gatagggcca aagctaacac tgttgacatg     1500

tttgatattg atccgaatct catatcctgg gattcaatgt ctgatgcccg agtatcaacc     1560

cagattagtg atttgtacct caaaaatggg ggggatgaat ctagggtgta tttcgagatt     1620

aacaataagc gaataaagag atctgattac aacataagtc agttggtcag accaaagttg     1680

tccgattcca ctagaaagaa tttgaacgat tctatatgga agcttaagag gacgagcgaa     1740

gagtatctga agctgagtaa acgcaagctt gagcttagca gggccgtagt caattatact     1800

atccggcaga gcaaattgct ttcaggaatc aacgacattg ttataattct cgaggacctc     1860

gacgtgaaaa agaaatttaa tgggaggggc atccgcgata ttggatggga taacttcttc     1920

agtagcagga aagaaaatag gtggtttata cctgccttcc ataaggcctt tagtgaactc     1980

agcagcaaca ggggcctctg cgtgatcgag gtaaacccgg cgtggacatc agcaacttgt     2040

cctgactgcg ggttttgttc taaggagaac cgggatggaa tcaactttac ttgccgaaag     2100

tgtggcgtgt cctatcacgc tgacatcgat gtcgctacac ttaatatagc ccgagttgcc     2160

gtacttggta aaccaatgag tgggccagct gatcgcgaaa gactgggcga cacgaaaaaa     2220

ccaagggtgg ctcgatccag gaaaaccatg aaacgcaagg atatttcaaa ctccactgtc     2280

gaggcaatgg taaccgcata g                                               2301


<210>  24
<211>  2298
<212>  DNA
<213>  Artificial

<220>
<223>  Human optimized


<220>
<221>  misc_feature
<222>  (1)..(2298)
<223>  cas_phi-4

<400>  24
atgtattccc ttgaaatggc agacttgaaa agtgaaccga gcttgttggc gaagctgttg       60

cgcgatcggt ttcctggcaa gtactggttg cccaaatact ggaaacttgc ggagaagaaa      120

agattgactg gaggagagga ggcagcttgt gaatatatgg cggataagca gctcgactca      180

ccgcccccaa acttcaggcc ccctgcacga tgtgtaatat tggcaaagtc cagaccattc      240

gaggattggc ccgtgcaccg cgttgcgtct aaagcacaat cttttgtaat cggactgagc      300

gagcaaggtt ttgcggcact tagggccgca ccacccagta cagcagatgc taggagagac      360

tggttgcgga gccacggcgc ctccgaagat gaccttatgg ctcttgaggc gcagctcctc      420

gagacaatca tgggtaatgc aattagcctt catgggggcg tactcaaaaa gatagacaat      480

gctaatgtta aggcagcaaa gcggctctcc ggccgaaacg aagcgaggct caacaaggga      540

ttgcaagagc ttccccctga acaggaagga agtgcgtatg gggcggatgg tcttttggtg      600

aatcccccgg gtcttaattt gaacatctac tgcaggaaaa gctgctgtcc aaaacccgtg      660

aaaaacactg ccaggttcgt ggggcactac cctggatacc tgcgagacag tgacagcatt      720

ttgattagtg ggaccatgga ccgactcacc ataatcgaag ggatgccagg gcatattcca      780

gcatggcagc gagaacaagg tttggtgaaa ccaggcgggc ggcggcgcag gcttagtggg      840

tcagagtcca atatgaggca aaaagtggac ccgagcacgg gaccccggcg aagtacgcgg      900

agtgggactg ttaaccgatc taaccagcgg acagggagaa acggtgaccc gttgcttgtc      960

gaaatacgga tgaaagaaga ctgggtcctt ttggacgcga gggggctgtt gcgcaacctc     1020

cgatggcgag aaagcaagag aggtctcagt tgtgaccacg aagatctgtc cttgagtggt     1080

ctcctcgcgc tgtttagtgg tgatccagta attgaccccg tccggaacga ggtagtattc     1140

ttgtacggtg agggaatcat tcccgttcgg tcaaccaaac cagtagggac gcgccaaagc     1200

aaaaagctcc tcgagaggca ggcatccatg ggccctttga cactgatctc ttgcgatttg     1260

ggacaaacca acctgattgc agggcgggcg tctgctatct cacttacaca cggaagcctg     1320

ggtgtaagat cctccgtcag gattgagctt gacccagaaa tcataaaatc cttcgagaga     1380

ttgcgcaagg acgcggatag gcttgaaacg gaaatcctga ctgcggcaaa agaaactttg     1440

agcgacgagc aacgaggtga ggtaaacagt cacgaaaagg actcccccca aactgcaaaa     1500

gcctcccttt gccgagaact cggcctccac cctccatctt tgccgtgggg gcagatgggt     1560

ccctccacga cttttatcgc cgacatgctt atcagtcacg gtcgggatga cgatgcattc     1620

ttgtcccatg gcgagtttcc tactctggaa aaaagaaaga aatttgataa gagattttgt     1680

cttgagagtc ggccgttgct ctctagtgag acccgcaaag ctctgaatga aagtctgtgg     1740

gaagttaagc ggaccagttc tgagtacgca aggctcagcc aaaggaaaaa ggagatggcg     1800

agacgagcag taaattttgt cgtagaaata agccggcgaa aaacaggact ttccaacgtg     1860

atcgtgaaca tcgaagatct taatgtgcgg atttttcatg gaggcggtaa acaggcgcca     1920

ggatgggatg ggttttttcg gccaaaaagt gaaaaccgct ggtttatcca agctatccac     1980

aaagcatttt ccgacttggc agctcaccat ggaattcctg taattgaatc cgatccacaa     2040

agaacatcca tgacttgccc ggaatgtggt cactgtgact caaaaaatcg caatggcgta     2100

cggttcctgt gcaaaggatg tggtgcttcc atggacgcag actttgatgc cgcatgtagg     2160

aatttggaac gggtcgcgct cacgggcaaa ccgatgccta aacctagcac ctcctgtgag     2220

cggcttctct ccgccaccac gggtaaagta tgtagcgatc attccctttc ccatgatgca     2280

atagaaaaag cgtcttag                                                   2298


<210>  25
<211>  2382
<212>  DNA
<213>  Artificial

<220>
<223>  Human optimized


<220>
<221>  misc_feature
<222>  (1)..(2382)
<223>  cas_phi-5

<400>  25
atgtcatccc ttcccactcc gctggagttg ttgaaacaga agcacgcgga cctcttcaaa       60

ggtcttcaat tctcaagcaa ggacaataag atggccggga aggtcttgaa aaaggatggc      120

gaagaggcgg ctctcgcatt cttgagtgaa aggggggtta gccgcggtga gctgcccaac      180

ttccggccac cggcgaaaac ccttgtggtc gcgcaatcaa gaccctttga ggagtttccc      240

atatatcggg tgagtgaggc tattcaactc tatgtatact cacttagcgt caaggaactt      300

gaaacagttc catcagggag ttccacgaaa aaagaacacc agaggttttt tcaagattca      360

agcgttcccg attttggcta tacctccgtg cagggtttga ataagatttt cggtctcgct      420

agaggcatat acttgggtgt catcacaagg ggcgaaaacc aattgcagaa ggcgaaatca      480

aaacatgagg cgctcaataa gaaacgccgc gccagcggcg aggcagagac ggagtttgat      540

ccaacaccat atgaatatat gactcctgag aggaagctgg cgaagccccc cggtgtaaat      600

catagtatta tgtgctacgt tgatatctct gtggacgaat ttgactttag gaacccggat      660

ggaattgtgc tgcctagtga atacgccgga tactgtaggg agatcaatac tgcgatagaa      720

aaaggtactg tagacaggct cggccatttg aaaggtggcc ccggatacat acctggacac      780

cagaggaaag aatctaccac ggaaggtcct aaaattaact tccgcaaggg taggataaga      840

cggtcatata cagcactgta tgccaagcga gattcccggc gcgtccgcca ggggaagctg      900

gctcttcctt cctataggca tcatatgatg aggctcaact ccaatgcaga atccgccatc      960

ctggcggtca tattttttgg taaagattgg gtagtgtttg atcttcgcgg actcttgagg     1020

aacgtgcgat ggcgcaacct tttcgtggat ggcagcactc ccagtacact cttggggatg     1080

ttcggagatc ccgtgatcga cccaaagcga ggcgtcgtag cgttttgcta caaggagcag     1140

atagttcctg tggtgagtaa aagtataaca aaaatggtta aggcacccga gttgctgaat     1200

aagctgtatc tgaaaagtga ggatcccctt gtccttgtcg ctattgatct tggtcagacc     1260

aaccctgttg gcgtcggcgt ttacagagta atgaacgctt ctctggatta tgaggtcgtg     1320

acgagatttg cccttgaatc tgagcttctt agggagattg aaagctatcg ccaacgaact     1380

aacgcgttcg aggcccagat tcgagccgaa acctttgatg cgatgacatc agaggagcaa     1440

gaagagatta cacgggttag agctttctca gcgagcaagg caaaagaaaa tgtttgccat     1500

agatttggca tgccggtaga tgctgttgat tgggccacaa tgggtagtaa caccattcat     1560

atcgccaagt gggtaatgag acatggcgac ccaagcctcg ttgaagtact cgagtatcgc     1620

aaagataatg aaataaaact tgacaaaaat ggggttccga aaaaagtgaa gctcaccgat     1680

aaacgcattg ctaaccttac gtcaattaga ttgcgattta gtcaagagac aagtaaacac     1740

tacaatgaca ccatgtggga gttgcgacgg aaacatcctg tttaccagaa gctctccaag     1800

agtaaggcag atttcagtag aagagtggtg aattccataa tacgccgagt caaccatctt     1860

gttccccgcg cccggatagt ttttataatt gaggatttga aaaaccttgg caaagtattt     1920

cacggctcag ggaaaagaga gctcggttgg gatagttatt tcgaaccaaa gtctgagaac     1980

aggtggttca ttcaagtact tcataaagcg tttagtgaga cgggtaagca taagggatac     2040

tatatcatag aatgctggcc caactggact tcctgtacat gtccaaaatg tagttgttgt     2100

gacagcgaaa accggcacgg ggaagttttc agatgcctgg cgtgcggcta cacttgcaat     2160

actgattttg gcactgcccc tgataacctt gtcaaaattg caacgacggg gaaaggcctc     2220

ccgggaccaa agaagcgatg taaaggatct tctaagggta agaacccgaa gattgcaagg     2280

tcatcagaaa ctggggttag cgtcacggag tctggggcac caaaagtcaa aaaatcatct     2340

ccaactcaaa cttcccagtc atcctcccag tcagcgccct ag                        2382


<210>  26
<211>  1325
<212>  DNA
<213>  Artificial

<220>
<223>  Human optimized


<220>
<221>  misc_feature
<222>  (1)..(1325)
<223>  cas_phi-6

<400>  26
atgaataaaa tagagaaaga aaaaacgcca cttgctaagc tcatgaacga gaattttgca       60

ggcttgaggt ttccgtttgc catcataaaa caggcaggca aaaaattgct caaagaaggc      120

gaactgaaaa ccatagaata catgacggga aaggggagta tcgagcctct gccaaatttt      180

aaaccacccg tcaaatgcct gattgttgct aaacgccgag atttgaaata cttcccgatc      240

tgcaaagcct cttgcgagat acagtcctac gtctattcac ttaactacaa ggactttatg      300

gattattttt caacacctat gacatcccag aagcagcatg aagaattttt caaaaagagc      360

gggcttaaca tcgaatacca gaacgtcgct ggtcttaatc tcattttcaa caatgtaaaa      420

aatacatata atggagtcat acttaaagtc aagaacagaa atgagaaatt gaagaaaaag      480

gctataaaga ataactacga attcgaggaa attaaaacgt tcaacgacga tggatgtctc      540

atcaacaagc cgggaataaa taatgtgatt tattgctttc aatccataag cccgaagatc      600

cttaagaata ttacgcacct cccgaaggaa tataacgact acgactgctc tgtggatcgc      660

aacattatcc aaaaatacgt aagccgattg gacatcccgg aatctcaacc tgggcacgtg      720

cctgaatggc agcgcaaatt gccagaattc aacaacacaa ataatcccag aagacgccgg      780

aagtggtact ctaatggtag aaatatatcc aaaggttact ctgtcgatca agtaaaccag      840

gcgaagattg aagacagctt gctcgcccag ataaagatcg gggaagactg gatcattttg      900

gacatacgag gactgctccg agatctcaac aggagagagc tcattagcta taagaacaaa      960

ctgacgataa aggacgttct tggatttttt tcagattacc ctataatcga catcaaaaaa     1020

aaccttgtaa cgttctgtta caaagagggg gttattcaag tagtctctca gaaaagtatt     1080

ggaaataaaa agtccaaaca attgttggag aaactcattg aaaataagcc gatagctctt     1140

gtttccatcg acctcggaca aacaaatcct gtaagtgtga agatctctaa gttgaacaag     1200

ataaacaaca aaataagcat agagtccttc acttacaggt tccttaacga ggaaatcctg     1260

aaagagatag agaaatatag gaaggactac gacaagctcg aactgaagct cattacgagg     1320

cttag                                                                 1325


<210>  27
<211>  2319
<212>  DNA
<213>  Artificial

<220>
<223>  Human optimized


<220>
<221>  misc_feature
<222>  (1)..(2319)
<223>  cas_phi-7

<400>  27
atgtccaaca cagccgtcag tactagggaa cacatgtcaa acaagacgac acccccttct       60

ccgctttcat tgctgttgag agcgcatttt cccggactga aatttgagtc tcaggattac      120

aagattgccg gcaaaaaact tcgcgatggt ggtcctgaag cagtgatttc atatctgaca      180

ggaaagggtc aagctaaact taaagacgtt aagcctccag ccaaggcttt tgtcatagct      240

caatctagac catttataga atgggacctg gtacgcgtaa gccgacagat tcaggaaaaa      300

atatttggca tcccagcaac taaggggcga ccaaagcaag atggtttgag cgagaccgca      360

ttcaatgaag ctgtagcatc tctcgaggtt gatggaaaat ccaagcttaa cgaggagacg      420

agagcagcgt tttatgaagt tcttggactg gacgctccct ccttgcacgc tcaagcccaa      480

aatgctctta taaaatccgc tatttcaata cgggagggcg tgctcaaaaa agtagaaaac      540

agaaatgaga agaacctctc caaaacgaaa cggcggaaag aggccggtga agaagcaaca      600

ttcgtggagg agaaagctca cgacgaaaga gggtacctga ttcatcctcc cggggtcaac      660

caaacgattc cagggtatca ggcggtggtt ataaaatcct gccctagtga ctttattggc      720

ctgccctcag gttgccttgc taaggagtca gcagaagcac tgacagacta tttgccgcat      780

gaccggatga ccatcccaaa ggggcagccg ggttacgtgc ctgagtggca gcatcctttg      840

ttgaataggc ggaaaaacag gagaagaagg gactggtatt cagcgtcact caacaaaccg      900

aaagcaacgt gcagtaagcg ctccggtact ccgaatagga agaactctag aacagaccag      960

atccaatctg gccgctttaa aggagctatt cctgtactta tgcgcttcca agatgaatgg     1020

gtcatcatcg atattcgggg gttgcttagg aatgcgagat atcggaaact gcttaaagag     1080

aaatccacga tccccgatct tctttcactt tttacaggtg atccaagcat tgatatgagg     1140

cagggtgttt gtacctttat atacaaagca ggtcaagcct gctcagccaa gatggttaag     1200

actaaaaatg cgccagagat cctgagcgag ctcacaaagt ctgggccggt tgtactggtt     1260

tccattgatc ttggccaaac caaccccatt gcggcaaagg tgtcacgggt aacgcagctt     1320

tctgatggcc aactctctca cgaaacgctt ttgcgggaac ttctcagtaa tgactcaagt     1380

gacgggaaag aaattgcaag ataccgagtg gcgtcagata ggctgcggga taagttggca     1440

aacctcgcag tcgagaggct ttccccggaa cataaaagcg agatacttcg cgcaaaaaat     1500

gacaccccgg cactgtgtaa agctcgagtt tgcgcagctc tgggattgaa cccagaaatg     1560

atagcatggg acaaaatgac tccctatacc gaatttctcg cgaccgctta tcttgagaag     1620

gggggagaca gaaaggtagc aaccctgaaa ccgaagaacc gcccggaaat gttgcgaaga     1680

gacataaaat ttaaaggaac agaaggtgtg agaatcgagg tctcaccaga ggctgcggaa     1740

gcttacagag aagcccaatg ggatctgcag cgcacgagtc ccgaatattt gcggctgagt     1800

acatggaagc aagaacttac gaaacgaatc ctcaaccaac tgcgccataa agccgcaaag     1860

tcttcacaat gcgaggtggt ggtgatggcg ttcgaagacc tgaatattaa gatgatgcac     1920

gggaacggta aatgggcaga cggtggatgg gacgcttttt ttatcaaaaa gcgagaaaat     1980

cgctggttca tgcaggcatt tcataaatcc ttgactgagc tgggtgctca taaaggagta     2040

cccacaatag aggtaactcc gcatcgaacg tccattacat gcactaaatg tggtcactgc     2100

gataaagcca acagggacgg cgaacgattc gcatgccaga aatgtggatt cgtagcccat     2160

gcggaccttg aaatcgctac cgacaatatc gagagggtcg cgctgactgg caaacccatg     2220

cctaagccag aatccgaacg aagtggggac gcaaagaaat cagttggggc acggaaggcc     2280

gccttcaagc cggaagagga tgcagaagcc gctgaatag                            2319


<210>  28
<211>  2154
<212>  DNA
<213>  Artificial

<220>
<223>  Human optimized


<220>
<221>  misc_feature
<222>  (1)..(2154)
<223>  cas_phi-8

<400>  28
atgataaaac caacggtcag tcaattcctc acgccgggtt tcaaactcat acgcaaccac       60

tcccgcacag cgggccttaa gttgaagaac gaaggggaag aggcctgcaa aaagttcgta      120

agggagaacg agatccctaa agacgaatgt cctaacttcc aaggcggccc tgcaattgcc      180

aacatcatcg ccaagagcag agaatttact gaatgggaga tttaccaaag cagcttggca      240

atccaagagg taatttttac acttcccaag gataagttgc ccgaaccgat cctcaaagag      300

gagtggaggg cgcaatggct tagcgaacac ggcctggata cggtgcctta caaagaagca      360

gcgggcttga atttgattat aaagaatgcc gttaatacct ataagggtgt tcaggtaaaa      420

gtagacaaca aaaataaaaa caatctggca aaaattaata ggaagaacga gatcgctaag      480

ctcaatggag aacaagagat ctccttcgag gaaatcaaag cctttgatga taaaggctat      540

ctccttcaga agcctagccc gaataagagc atttactgtt atcagtccgt atctcctaaa      600

ccatttatta ccagtaaata tcataatgtt aacttgcctg aagaatatat tggatactac      660

aggaagtcaa acgagcctat cgtgagtcca tatcagtttg acagattgag aatacccatt      720

ggcgagcccg gttatgtgcc caagtggcaa tatacattcc tttccaagaa ggagaataaa      780

cggcgaaaac tgtcaaaacg aataaagaac gtctcaccca tactcggcat catatgcatt      840

aagaaggact ggtgtgtctt cgatatgcgc ggacttctcc ggaccaacca ctggaagaaa      900

taccacaaac ctaccgattc catcaatgac ctgttcgatt acttcacagg agatcccgtc      960

atagacacga aagcgaatgt ggttcgcttc agatacaaaa tggagaacgg aatcgtaaac     1020

tacaagcccg tgcgcgagaa aaagggcaaa gaactcctgg aaaacatatg cgaccagaat     1080

gggtcttgta aacttgccac tgtggatgtc ggccagaata atcctgttgc tataggcctt     1140

tttgaattga aaaaggttaa tggcgaactc acgaagacgc tgatttctcg gcatcccact     1200

cctatagact tttgtaataa aatcaccgct taccgggaga ggtacgataa attggagtcc     1260

agcattaaac tcgatgccat taaacagctt acatcagaac agaaaataga agtagacaac     1320

tacaataata actttacacc ccagaatacg aaacaaatcg tatgctcaaa gcttaacatt     1380

aacccgaatg acctgccatg ggataaaatg atctccggca cccacttcat atccgaaaag     1440

gcgcaagttt caaacaagtc tgaaatatat ttcacgtcta cggacaaggg caagaccaag     1500

gacgtcatga agtcagacta taagtggttc caagattaca agccaaagct cagcaaagaa     1560

gtgcgagatg ccctgagcga tatcgagtgg aggctcagga gggaatcact cgagtttaac     1620

aaattgtcca aaagtcggga acaggacgca cgacaactcg ctaactggat ttcttctatg     1680

tgtgacgtaa ttggtattga aaacctcgta aagaagaaca atttttttgg gggtagcgga     1740

aaacgggaac ctggctggga taatttctac aagccgaaaa aggaaaaccg gtggtggatt     1800

aatgcaatcc ataaagcatt gactgaactc agccaaaaca aaggtaagcg ggttatcttg     1860

ctcccggcga tgcgcacctc tataacatgc cccaaatgta aatattgcga ctccaaaaat     1920

cgcaacggcg aaaagttcaa ctgtctcaag tgtggcattg agctgaacgc agatatagac     1980

gtggcgacag agaacctcgc aacggtcgcg ataaccgcgc aaagtatgcc gaagcccaca     2040

tgtgaacgca gtggagacgc taaaaaacca gtccgggcaa ggaaggcgaa ggcgcctgaa     2100

tttcacgaca agttggcgcc cagttatacg gtggtcttgc gggaagctgt gtga           2154


<210>  29
<211>  2382
<212>  DNA
<213>  Artificial

<220>
<223>  Human optimized


<220>
<221>  misc_feature
<222>  (1)..(2382)
<223>  cas_phi-9

<400>  29
atgcgatcca gtagagaaat aggcgataag atcctgatgc ggcagcccgc cgaaaagacc       60

gcctttcaag tttttcgcca ggaagtcatt ggcacccaaa agttgtcagg gggcgacgcg      120

aaaacagccg gtagactgta caaacaaggc aaaatggagg cggcaagaga gtggctcctc      180

aagggcgcgc gggatgacgt ccctccgaat ttccaaccac ctgctaaatg tcttgttgtc      240

gccgtgagtc acccttttga agaatgggat attagcaaaa ctaatcatga cgttcaagcc      300

tatatctacg cccaaccctt gcaggctgaa ggacacctta atggcctgag cgaaaagtgg      360

gaggacacaa gcgccgacca gcacaaactt tggttcgaga aaactggcgt gccggacagg      420

ggcttgccag tgcaggctat caacaagatc gcaaaagcag cggttaaccg cgcgtttgga      480

gtagttagga aagtcgagaa caggaacgag aagaggcggt cacgagataa tcggatagca      540

gagcacaatc gggagaatgg gctgaccgag gtcgtgcgag aagctccaga ggtagcaacg      600

aacgccgatg gcttcctgct tcatccgcca ggaatcgacc cttccatact ttcatacgca      660

tcagtatccc ccgttcccta caattcctcc aaacatagtt ttgtcagact ccctgaggag      720

tatcaagctt acaatgtcga gccagatgct ccaattccac aattcgtcgt agaggataga      780

tttgctattc cacccgggca gcccggttac gttcctgagt ggcaacgatt gaaatgttcc      840

accaataaac atcgccgaat gcgacaatgg tccaatcaag actacaagcc caaagccggc      900

cgacgagcaa aaccgctgga gtttcaagct catcttacga gggaacgagc aaaaggtgcc      960

ctgctcgtcg taatgcgcat taaagaagat tgggtagttt tcgacgtgag aggcctgttg     1020

cgcaatgtgg agtggaggaa ggttctctct gaagaggcaa gagaaaaatt gacgttgaag     1080

gggctccttg acttgtttac aggagatccg gtaattgata caaaacgggg aatcgtaact     1140

tttctttaca aggcggagat cactaaaata ttgtccaaac gaacggtgaa gactaagaac     1200

gcgcgcgatt tgttgctccg cctcacagaa cctggagaag acggattgcg acgggaagtc     1260

gggcttgtag ccgtggatct tgggcagaca cacccgatag ctgcagcgat ctatcgcatt     1320

gggcgaacca gcgcaggagc tctcgaatcc acagttcttc accgccaggg tttgcgggag     1380

gatcaaaaag agaagttgaa agagtaccgg aaaagacata cagcgttgga tagtcggctt     1440

agaaaggagg ccttcgaaac gttgtcagtt gagcagcaga aagaaattgt aaccgtaagt     1500

gggagtggtg cccaaatcac gaaagacaag gtctgcaact atcttggcgt agatccctct     1560

actcttccat gggagaagat gggctcctac actcatttta tttccgacga tttcctgcgc     1620

cgaggcggag atcccaacat cgtacatttt gatagacagc ctaagaaagg caaagtatca     1680

aaaaaatccc agcggataaa gcggtccgat tctcaatggg tcgggcggat gagaccgagg     1740

cttagtcagg aaaccgcaaa agcaaggatg gaggcagact gggctgccca aaacgagaac     1800

gaagaatata agaggctggc tcgcagtaaa caggagctgg ctcgctggtg tgttaatact     1860

ctgttgcaga atacacgatg catcacccag tgtgatgaaa ttgtcgtcgt catagaggac     1920

ctcaatgtta aatccctgca cggtaaaggg gctagagagc ctggctggga caattttttc     1980

actcccaaaa cagagaatag atggttcatt cagattctcc ataagacatt ttcagaactg     2040

cctaaacaca ggggcgaaca cgtcatcgaa ggttgtcccc ttcggaccag tatcacttgt     2100

cccgcatgtt cttattgtga taagaactca cgcaatggtg aaaaatttgt gtgcgtcgct     2160

tgcggggcta ccttccacgc agatttcgag gtcgcaacct acaaccttgt acgccttgcc     2220

acgaccggaa tgcctatgcc gaagagtttg gagcggcaag gcggaggaga gaaagccggc     2280

ggcgcccgaa aagcccgaaa gaaagcaaag caggtcgaaa agattgtggt ccaagcgaac     2340

gctaacgtta ctatgaatgg tgccagtctt cattccccat ag                        2382


<210>  30
<211>  2439
<212>  DNA
<213>  Artificial

<220>
<223>  Human optimized


<220>
<221>  misc_feature
<222>  (1)..(2439)
<223>  cas_phi-10

<400>  30
atggacatgc tcgatacgga gacaaattac gcgacagaga ccccagccca acaacaagat       60

tacagcccga aacccccgaa gaaagcccag agagccccaa agggatttag taagaaggcc      120

cggcctgaaa aaaaaccccc gaaacctatc actttgttca cacaaaaaca tttttccggt      180

gtccggttcc ttaaacgggt tattcgggat gcttcaaaaa tactgaaact gagcgagagt      240

cgaacgatta cgtttctcga acaggccatt gagcgagatg gctctgcccc ccccgatgtg      300

actccaccgg ttcataatac gattatggcc gtaacacgcc ctttcgaaga gtggcccgaa      360

gttatcctca gcaaggctct tcaaaagcac tgttacgccc ttacaaagaa aataaagata      420

aagacttggc cgaaaaaagg acctggcaaa aagtgtcttg ctgcatggtc cgcgagaaca      480

aaaatcccgc tgatcccagg acaagtgcaa gcaaccaacg gactgttcga ccggatcggg      540

agcatttatg acggcgtgga gaaaaaggta accaaccgaa atgcgaacaa aaagttggag      600

tacgatgagg ctatcaaaga gggaaggaat cccgcggttc ctgagtacga aacagcgtac      660

aacatagacg gcacattgat taataagccg ggatacaatc ccaacctcta catcacccag      720

agtcgaacac cgcgactcat tacagaggca gatagacccc tcgttgaaaa gatcctgtgg      780

caaatggtag agaagaagac gcagagccga aaccaggctc gcagagctag gctcgagaaa      840

gccgcgcacc ttcagggcct tcctgtccca aaatttgtgc ctgaaaaggt agatcgctca      900

cagaaaatcg agatccggat aatcgacccc ctcgacaaaa tcgaaccata tatgccccag      960

gaccggatgg caataaaggc gagtcaggat gggcacgtac catactggca acgcccattt     1020

ctctcaaaga ggagaaatag aagagtaaga gcaggttggg ggaaacaagt gtcatctatc     1080

caggcgtggc tcactggcgc tctgcttgtc atagtacggc tcggtaatga agcattcctg     1140

gccgatatcc gaggagcatt gaggaacgca cagtggagga agctcctcaa gccggatgcc     1200

acttaccagt cactgtttaa cctctttacg ggagaccctg tcgtaaacac gaggacgaac     1260

cacctgacca tggcctaccg ggagggtgtc gtgaatatcg tcaagagccg ctcttttaag     1320

ggcagacaga ccagagaaca ccttctcacc ttgctgggtc aagggaaaac ggtggcaggc     1380

gtctcctttg atcttgggca gaagcatgcg gcgggattgt tggcggctca ttttggcctg     1440

ggggaagatg gtaatcccgt attcactccg atccaagcgt gtttccttcc acaaaggtac     1500

ttggacagtt tgaccaacta taggaatagg tatgacgcgc tcacattgga tatgcgacgc     1560

caaagtctcc tggcgctcac accagctcaa caacaagaat ttgcagacgc gcaacgcgac     1620

ccaggggggc aggcgaagcg cgcatgctgt cttaaactta atttgaatcc cgatgaaata     1680

agatgggatc ttgttagcgg aatctcaacc atgataagcg atctttacat cgagaggggt     1740

ggggatcctc gagatgtgca tcaacaggtg gagaccaagc cgaaaggtaa acgaaaatca     1800

gaaattcgaa tccttaagat tcgagatgga aagtgggctt atgacttccg gcccaaaatt     1860

gccgacgaga ctagaaaagc acagcgagag cagctctgga agctgcagaa agccagcagt     1920

gagttcgagc gcttgagtcg gtacaaaatt aacatagcca gagcaatcgc caactgggcc     1980

ctccagtggg ggcgagagct tagcggttgt gacattgtga tacccgtgct cgaagacctc     2040

aacgtcggtt ccaaattttt cgacggtaag ggcaaatggc tgctcggctg ggataatcgg     2100

ttcactccaa aaaaggagaa tagatggttt ataaaagtgc ttcataaggc tgttgccgag     2160

ttggctcccc atcgcggggt cccggtctac gaggttatgc cacaccgcac gagcatgact     2220

tgccccgcat gccactattg tcaccccaca aatagggaag gggatcgctt cgaatgtcaa     2280

tcatgtcatg tagtcaagaa tacagatagg gacgtcgcac cttataatat acttcgcgtg     2340

gcggtggaag gcaagacgct ggaccgatgg caggccgaga agaaacctca agcggaaccg     2400

gataggccaa tgatactcat tgacaatcag gaatcttga                            2439


<210>  31
<211>  726
<212>  PRT
<213>  Artificial

<220>
<223>  Mutant Cas_phi-3


<220>
<221>  misc_feature
<222>  (1)..(726)
<223>  cas_phi-3 C-terminal truncation

<400>  31

Met Glu Lys Glu Ile Thr Glu Leu Thr Lys Ile Arg Arg Glu Phe Pro 
1               5                   10                  15      


Asn Lys Lys Phe Ser Ser Thr Asp Met Lys Lys Ala Gly Lys Leu Leu 
            20                  25                  30          


Lys Ala Glu Gly Pro Asp Ala Val Arg Asp Phe Leu Asn Ser Cys Gln 
        35                  40                  45              


Glu Ile Ile Gly Asp Phe Lys Pro Pro Val Lys Thr Asn Ile Val Ser 
    50                  55                  60                  


Ile Ser Arg Pro Phe Glu Glu Trp Pro Val Ser Met Val Gly Arg Ala 
65                  70                  75                  80  


Ile Gln Glu Tyr Tyr Phe Ser Leu Thr Lys Glu Glu Leu Glu Ser Val 
                85                  90                  95      


His Pro Gly Thr Ser Ser Glu Asp His Lys Ser Phe Phe Asn Ile Thr 
            100                 105                 110         


Gly Leu Ser Asn Tyr Asn Tyr Thr Ser Val Gln Gly Leu Asn Leu Ile 
        115                 120                 125             


Phe Lys Asn Ala Lys Ala Ile Tyr Asp Gly Thr Leu Val Lys Ala Asn 
    130                 135                 140                 


Asn Lys Asn Lys Lys Leu Glu Lys Lys Phe Asn Glu Ile Asn His Lys 
145                 150                 155                 160 


Arg Ser Leu Glu Gly Leu Pro Ile Ile Thr Pro Asp Phe Glu Glu Pro 
                165                 170                 175     


Phe Asp Glu Asn Gly His Leu Asn Asn Pro Pro Gly Ile Asn Arg Asn 
            180                 185                 190         


Ile Tyr Gly Tyr Gln Gly Cys Ala Ala Lys Val Phe Val Pro Ser Lys 
        195                 200                 205             


His Lys Met Val Ser Leu Pro Lys Glu Tyr Glu Gly Tyr Asn Arg Asp 
    210                 215                 220                 


Pro Asn Leu Ser Leu Ala Gly Phe Arg Asn Arg Leu Glu Ile Pro Glu 
225                 230                 235                 240 


Gly Glu Pro Gly His Val Pro Trp Phe Gln Arg Met Asp Ile Pro Glu 
                245                 250                 255     


Gly Gln Ile Gly His Val Asn Lys Ile Gln Arg Phe Asn Phe Val His 
            260                 265                 270         


Gly Lys Asn Ser Gly Lys Val Lys Phe Ser Asp Lys Thr Gly Arg Val 
        275                 280                 285             


Lys Arg Tyr His His Ser Lys Tyr Lys Asp Ala Thr Lys Pro Tyr Lys 
    290                 295                 300                 


Phe Leu Glu Glu Ser Lys Lys Val Ser Ala Leu Asp Ser Ile Leu Ala 
305                 310                 315                 320 


Ile Ile Thr Ile Gly Asp Asp Trp Val Val Phe Asp Ile Arg Gly Leu 
                325                 330                 335     


Tyr Arg Asn Val Phe Tyr Arg Glu Leu Ala Gln Lys Gly Leu Thr Ala 
            340                 345                 350         


Val Gln Leu Leu Asp Leu Phe Thr Gly Asp Pro Val Ile Asp Pro Lys 
        355                 360                 365             


Lys Gly Val Val Thr Phe Ser Tyr Lys Glu Gly Val Val Pro Val Phe 
    370                 375                 380                 


Ser Gln Lys Ile Val Pro Arg Phe Lys Ser Arg Asp Thr Leu Glu Lys 
385                 390                 395                 400 


Leu Thr Ser Gln Gly Pro Val Ala Leu Leu Ser Val Asp Leu Gly Gln 
                405                 410                 415     


Asn Glu Pro Val Ala Ala Arg Val Cys Ser Leu Lys Asn Ile Asn Asp 
            420                 425                 430         


Lys Ile Thr Leu Asp Asn Ser Cys Arg Ile Ser Phe Leu Asp Asp Tyr 
        435                 440                 445             


Lys Lys Gln Ile Lys Asp Tyr Arg Asp Ser Leu Asp Glu Leu Glu Ile 
    450                 455                 460                 


Lys Ile Arg Leu Glu Ala Ile Asn Ser Leu Glu Thr Asn Gln Gln Val 
465                 470                 475                 480 


Glu Ile Arg Asp Leu Asp Val Phe Ser Ala Asp Arg Ala Lys Ala Asn 
                485                 490                 495     


Thr Val Asp Met Phe Asp Ile Asp Pro Asn Leu Ile Ser Trp Asp Ser 
            500                 505                 510         


Met Ser Asp Ala Arg Val Ser Thr Gln Ile Ser Asp Leu Tyr Leu Lys 
        515                 520                 525             


Asn Gly Gly Asp Glu Ser Arg Val Tyr Phe Glu Ile Asn Asn Lys Arg 
    530                 535                 540                 


Ile Lys Arg Ser Asp Tyr Asn Ile Ser Gln Leu Val Arg Pro Lys Leu 
545                 550                 555                 560 


Ser Asp Ser Thr Arg Lys Asn Leu Asn Asp Ser Ile Trp Lys Leu Lys 
                565                 570                 575     


Arg Thr Ser Glu Glu Tyr Leu Lys Leu Ser Lys Arg Lys Leu Glu Leu 
            580                 585                 590         


Ser Arg Ala Val Val Asn Tyr Thr Ile Arg Gln Ser Lys Leu Leu Ser 
        595                 600                 605             


Gly Ile Asn Asp Ile Val Ile Ile Leu Glu Asp Leu Asp Val Lys Lys 
    610                 615                 620                 


Lys Phe Asn Gly Arg Gly Ile Arg Asp Ile Gly Trp Asp Asn Phe Phe 
625                 630                 635                 640 


Ser Ser Arg Lys Glu Asn Arg Trp Phe Ile Pro Ala Phe His Lys Ala 
                645                 650                 655     


Phe Ser Glu Leu Ser Ser Asn Arg Gly Leu Cys Val Ile Glu Val Asn 
            660                 665                 670         


Pro Ala Trp Thr Ser Ala Thr Cys Pro Asp Cys Gly Phe Cys Ser Lys 
        675                 680                 685             


Glu Asn Arg Asp Gly Ile Asn Phe Thr Cys Arg Lys Cys Gly Val Ser 
    690                 695                 700                 


Tyr His Ala Asp Ile Asp Val Ala Thr Leu Asn Ile Ala Arg Val Ala 
705                 710                 715                 720 


Val Leu Gly Lys Pro Met 
                725     


<210>  32
<211>  2178
<212>  DNA
<213>  Artificial

<220>
<223>  Bacteria optimized


<220>
<221>  misc_feature
<222>  (1)..(2178)
<223>  cas_phi-3 C-terminal truncation

<400>  32
atggaaaaag aaattaccga actgaccaaa attcgccgcg aatttccgaa caaaaaattt       60

agcagcaccg atatgaaaaa agcgggcaaa ctgctgaaag cggaaggccc ggatgcggtg      120

cgcgattttc tgaacagctg ccaggaaatt attggcgatt ttaaaccgcc ggtgaaaacc      180

aacattgtga gcattagccg cccgtttgaa gaatggccgg tgagcatggt gggccgcgcg      240

attcaggaat attattttag cctgaccaaa gaagaactgg aaagcgtgca tccgggcacc      300

agcagcgaag atcataaaag cttttttaac attaccggcc tgagcaacta taactatacc      360

agcgtgcagg gcctgaacct gatttttaaa aacgcgaaag cgatttatga tggcaccctg      420

gtgaaagcga acaacaaaaa caaaaaactg gaaaaaaaat ttaacgaaat taaccataaa      480

cgcagcctgg aaggcctgcc gattattacc ccggattttg aagaaccgtt tgatgaaaac      540

ggccatctga acaacccgcc gggcattaac cgcaacattt atggctatca gggctgcgcg      600

gcgaaagtgt ttgtgccgag caaacataaa atggtgagcc tgccgaaaga atatgaaggc      660

tataaccgcg atccgaacct gagcctggcg ggctttcgca accgcctgga aattccggaa      720

ggcgaaccgg gccatgtgcc gtggtttcag cgcatggata ttccggaagg ccagattggc      780

catgtgaaca aaattcagcg ctttaacttt gtgcatggca aaaacagcgg caaagtgaaa      840

tttagcgata aaaccggccg cgtgaaacgc tatcatcata gcaaatataa agatgcgacc      900

aaaccgtata aatttctgga agaaagcaaa aaagtgagcg cgctggatag cattctggcg      960

attattacca ttggcgatga ttgggtggtg tttgatattc gcggcctgta tcgcaacgtg     1020

ttttatcgcg aactggcgca gaaaggcctg accgcggtgc agctgctgga tctgtttacc     1080

ggcgatccgg tgattgatcc gaaaaaaggc gtggtgacct ttagctataa agaaggcgtg     1140

gtgccggtgt ttagccagaa aattgtgccg cgctttaaaa gccgcgatac cctggaaaaa     1200

ctgaccagcc agggcccggt ggcgctgctg agcgtggatc tgggccagaa cgaaccggtg     1260

gcggcgcgcg tgtgcagcct gaaaaacatt aacgataaaa ttaccctgga taacagctgc     1320

cgcattagct ttctggatga ttataaaaaa cagattaaag attatcgcga tagcctggat     1380

gaactggaaa ttaaaattcg cctggaagcg attaacagcc tggaaaccaa ccagcaggtg     1440

gaaattcgcg atctggatgt gtttagcgcg gatcgcgcga aagcgaacac cgtggatatg     1500

tttgatattg atccgaacct gattagctgg gatagcatga gcgatgcgcg cgtgagcacc     1560

cagattagcg atctgtatct gaaaaacggc ggcgatgaaa gccgcgtgta ttttgaaatt     1620

aacaacaaac gcattaaacg cagcgattat aacattagcc agctggtgcg cccgaaactg     1680

agcgatagca cccgcaaaaa cctgaacgat agcatttgga aactgaaacg caccagcgaa     1740

gaatatctga aactgagcaa acgcaaactg gaactgagcc gcgcggtggt gaactatacc     1800

attcgccaga gcaaactgct gagcggcatt aacgatattg tgattattct ggaagatctg     1860

gatgtgaaaa aaaaatttaa cggccgcggc attcgcgata ttggctggga taactttttt     1920

agcagccgca aagaaaaccg ctggtttatt ccggcgtttc ataaagcgtt tagcgaactg     1980

agcagcaacc gcggcctgtg cgtgattgaa gtgaacccgg cgtggaccag cgcgacctgc     2040

ccggattgcg gcttttgcag caaagaaaac cgcgatggca ttaactttac ctgccgcaaa     2100

tgcggcgtga gctatcatgc ggatattgat gtggcgaccc tgaacattgc gcgcgtggcg     2160

gtgctgggca aaccgatg                                                   2178


<210>  33
<211>  2178
<212>  DNA
<213>  Artificial

<220>
<223>  Human optimized


<220>
<221>  misc_feature
<222>  (1)..(2178)
<223>  cas_phi-3 C-terminal truncation

<400>  33
atggaaaagg agatcacaga actgaccaag atacgcaggg agtttcccaa caaaaagttc       60

agctcaacag atatgaaaaa agctggtaag cttctgaaag cggaagggcc tgatgctgta      120

cgcgatttct tgaattcatg tcaagagatc ataggtgatt tcaaaccgcc tgtcaagaca      180

aatattgtga gtattagtcg cccattcgag gaatggccag tcagtatggt cggtcgagcc      240

atccaagagt attacttctc tttgacaaaa gaggaactcg aaagcgtgca tccaggcacg      300

agcagcgaag accataagtc cttcttcaat attacaggac tgtctaacta caactataca      360

tctgtgcagg gattgaatct gatattcaaa aacgcaaaag ccatctatga cggcaccctt      420

gtaaaggcca acaacaaaaa caagaagctt gaaaagaagt ttaacgaaat caaccacaaa      480

aggtcacttg aaggtcttcc aattataact ccggacttcg aagagccttt tgatgaaaat      540

ggacacctca acaatccgcc agggataaac cgaaatatat acgggtacca gggatgtgca      600

gctaaggtct ttgtgccgag taagcataag atggtctcct tgcctaagga gtacgaaggt      660

tacaatcgcg atccgaatct cagtcttgcc ggttttagga accggctgga aattcctgag      720

ggcgagcccg ggcacgttcc atggtttcag cgaatggaca ttcctgaggg acaaatcgga      780

cacgtaaata agattcagag atttaacttc gtccatggca aaaatagcgg gaaggtcaag      840

ttcagcgaca agacagggag ggttaagaga tatcaccata gcaaatacaa agatgccacg      900

aaaccataca aattcctgga ggaaagtaag aaagtctccg cgctggactc aatcctggca      960

atcattacga taggagacga ctgggtggtt ttcgatatac gggggttgta tcggaacgtg     1020

ttttatcgcg aattggcaca aaaaggtctc acagcagtac aattgctgga tctgttcacg     1080

ggtgaccctg tcatagatcc taaaaaggga gtcgtgactt tcagctacaa agagggagta     1140

gtcccagtgt ttagccaaaa gatcgttcca cgatttaagt caagagacac attggagaaa     1200

ctgacctctc aaggtcctgt ggcgctcctg tctgttgatc tgggacagaa cgagcccgta     1260

gcagccagag tttgttcact taaaaatata aacgacaaaa ttacgctcga caatagctgt     1320

cgaatcagtt tcctggacga ctacaagaaa cagataaagg actacagaga cagtcttgac     1380

gaactggaaa ttaagatccg cctggaggcc attaactccc tcgagacaaa ccaacaagtt     1440

gaaattcggg acctcgacgt attttctgcg gacagagcaa aagccaatac agtcgacatg     1500

ttcgatatag accctaattt gatatcctgg gattctatgt ccgacgcgcg ggtatccacg     1560

caaatctctg atctttacct taagaacgga ggcgatgaga gtagggttta tttcgaaatc     1620

aataataagc gaataaaacg ctccgattac aacattagtc aactggtgag gcccaagctg     1680

agcgactcaa cccggaagaa cttgaacgat agcatctgga agctcaaacg aactagtgag     1740

gagtacttga aactgtcaaa acggaaactg gagcttagtc gggccgtggt gaactatacg     1800

atcaggcagt caaagcttct gagtggaatt aacgatatcg tcataatatt ggaagatttg     1860

gacgtaaaaa aaaagttcaa cgggagaggc attcgcgata tcggttggga caactttttc     1920

tctagtagga aggaaaaccg gtggtttatt cctgctttcc ataaagcttt ctccgagttg     1980

tcatcaaata ggggcttgtg tgtgattgag gttaatccgg cgtggacatc agcgacctgt     2040

ccggattgtg ggttttgctc caaggaaaac cgagatggga tcaactttac ctgccgaaag     2100

tgtggagtgt cctatcatgc tgacatagac gtagctaccc tcaatatcgc gagggttgcg     2160

gtgcttggga agccaatg                                                   2178


<210>  34
<211>  25
<212>  RNA
<213>  Artificial

<220>
<223>  crRNA constant region


<220>
<221>  misc_feature
<222>  (1)..(25)
<223>  cas_phi-1 crRNA constant region

<400>  34
aaacgauugc ucgauuaguc gagac                                             25


<210>  35
<211>  25
<212>  RNA
<213>  Artificial

<220>
<223>  crRNA constant region


<220>
<221>  misc_feature
<222>  (1)..(25)
<223>  cas_phi-2 crRNA constant region

<400>  35
caacgauugc cccucacgag gggac                                             25


<210>  36
<211>  25
<212>  RNA
<213>  Artificial

<220>
<223>  crRNA constant region


<220>
<221>  misc_feature
<222>  (1)..(25)
<223>  cas_phi-3 crRNA constant region

<400>  36
uauugauugc ccaguacgcu gggac                                             25


<210>  37
<211>  45
<212>  RNA
<213>  Artificial

<220>
<223>  crRNA


<220>
<221>  misc_feature
<222>  (1)..(45)
<223>  Example crRNA

<400>  37
uauugauugc ccaguacgcu gggacagcug guaaugggau accuu                       45


<210>  38
<211>  37
<212>  DNA
<213>  Artificial

<220>
<223>  Template strand


<220>
<221>  misc_feature
<222>  (1)..(37)
<223>  Example template strand sequence

<400>  38
gctgtagcac aaggtatccc attaccagct gaattac                                37


<210>  39
<211>  37
<212>  DNA
<213>  Artificial

<220>
<223>  Non template strand


<220>
<221>  misc_feature
<222>  (1)..(37)
<223>  Example non-template strand sequence

<400>  39
gtaattcagc tggtaatggg ataccttgtg ctacagc                                37


