                         SEQUENCE LISTING

<110>  Orph Pharma IP Company Limited
 
<120>  BIOMARKERS AND METHODS FOR CLASSIFYING SUBJECTS FOLLOWING VIRAL 
       EXPOSURE

<130>  P034135WO

<160>  16    

<170>  PatentIn version 3.5

<210>  1
<211>  1012
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Thr Lys His Pro Pro Asn Arg Arg Gly Ile Ser Phe Glu Val Gly 
1               5                   10                  15      


Ala Gln Leu Glu Ala Arg Asp Arg Leu Lys Asn Trp Tyr Pro Ala His 
            20                  25                  30          


Ile Glu Asp Ile Asp Tyr Glu Glu Gly Lys Val Leu Ile His Phe Lys 
        35                  40                  45              


Arg Trp Asn His Arg Tyr Asp Glu Trp Phe Cys Trp Asp Ser Pro Tyr 
    50                  55                  60                  


Leu Arg Pro Leu Glu Lys Ile Gln Leu Arg Lys Glu Gly Leu His Glu 
65                  70                  75                  80  


Glu Asp Gly Ser Ser Glu Phe Gln Ile Asn Glu Gln Val Leu Ala Cys 
                85                  90                  95      


Trp Ser Asp Cys Arg Phe Tyr Pro Ala Lys Val Thr Ala Val Asn Lys 
            100                 105                 110         


Asp Gly Thr Tyr Thr Val Lys Phe Tyr Asp Gly Val Val Gln Thr Val 
        115                 120                 125             


Lys His Ile His Val Lys Ala Phe Ser Lys Asp Gln Asn Ile Val Gly 
    130                 135                 140                 


Asn Ala Arg Pro Lys Glu Thr Asp His Lys Ser Leu Ser Ser Ser Pro 
145                 150                 155                 160 


Asp Lys Arg Glu Lys Phe Lys Glu Gln Arg Lys Ala Thr Val Asn Val 
                165                 170                 175     


Lys Lys Asp Lys Glu Asp Lys Pro Leu Lys Thr Glu Lys Arg Pro Lys 
            180                 185                 190         


Gln Pro Asp Lys Glu Gly Lys Leu Ile Cys Ser Glu Lys Gly Lys Val 
        195                 200                 205             


Ser Glu Lys Ser Leu Pro Lys Asn Glu Lys Glu Asp Lys Glu Asn Ile 
    210                 215                 220                 


Ser Glu Asn Asp Arg Glu Tyr Ser Gly Asp Ala Gln Val Asp Lys Lys 
225                 230                 235                 240 


Pro Glu Asn Asp Ile Val Lys Ser Pro Gln Glu Asn Leu Arg Glu Pro 
                245                 250                 255     


Lys Arg Lys Arg Gly Arg Pro Pro Ser Ile Ala Pro Thr Ala Val Asp 
            260                 265                 270         


Ser Asn Ser Gln Thr Leu Gln Pro Ile Thr Leu Glu Leu Arg Arg Arg 
        275                 280                 285             


Lys Ile Ser Lys Gly Cys Glu Val Pro Leu Lys Arg Pro Arg Leu Asp 
    290                 295                 300                 


Lys Asn Ser Ser Gln Glu Lys Ser Lys Asn Tyr Ser Glu Asn Thr Asp 
305                 310                 315                 320 


Lys Asp Leu Ser Arg Arg Arg Ser Ser Arg Leu Ser Thr Asn Gly Thr 
                325                 330                 335     


His Glu Ile Leu Asp Pro Asp Leu Val Val Ser Asp Leu Val Asp Thr 
            340                 345                 350         


Asp Pro Leu Gln Asp Thr Leu Ser Ser Thr Lys Glu Ser Glu Glu Gly 
        355                 360                 365             


Gln Leu Lys Ser Ala Leu Glu Ala Gly Gln Val Ser Ser Ala Leu Thr 
    370                 375                 380                 


Cys His Ser Phe Gly Asp Gly Ser Gly Ala Ala Gly Leu Glu Leu Asn 
385                 390                 395                 400 


Cys Pro Ser Met Gly Glu Asn Thr Met Lys Thr Glu Pro Thr Ser Pro 
                405                 410                 415     


Leu Val Glu Leu Gln Glu Ile Ser Thr Val Glu Val Thr Asn Thr Phe 
            420                 425                 430         


Lys Lys Thr Asp Asp Phe Gly Ser Ser Asn Ala Pro Ala Val Asp Leu 
        435                 440                 445             


Asp His Lys Phe Arg Cys Lys Val Val Asp Cys Leu Lys Phe Phe Arg 
    450                 455                 460                 


Lys Ala Lys Leu Leu His Tyr His Met Lys Tyr Phe His Gly Met Glu 
465                 470                 475                 480 


Lys Ser Leu Glu Pro Glu Glu Ser Pro Gly Lys Arg His Val Gln Thr 
                485                 490                 495     


Arg Gly Pro Ser Ala Ser Asp Lys Pro Ser Gln Glu Thr Leu Thr Arg 
            500                 505                 510         


Lys Arg Val Ser Ala Ser Ser Pro Thr Thr Lys Asp Lys Glu Lys Asn 
        515                 520                 525             


Lys Glu Lys Lys Phe Lys Glu Phe Val Arg Val Lys Pro Lys Lys Lys 
    530                 535                 540                 


Lys Lys Lys Lys Lys Lys Thr Lys Pro Glu Cys Pro Cys Ser Glu Glu 
545                 550                 555                 560 


Ile Ser Asp Thr Ser Gln Glu Pro Ser Pro Pro Lys Ala Phe Ala Val 
                565                 570                 575     


Thr Arg Cys Gly Ser Ser His Lys Pro Gly Val His Met Ser Pro Gln 
            580                 585                 590         


Leu His Gly Pro Glu Ser Gly His His Lys Gly Lys Val Lys Ala Leu 
        595                 600                 605             


Glu Glu Asp Asn Leu Ser Glu Ser Ser Ser Glu Ser Phe Leu Trp Ser 
    610                 615                 620                 


Asp Asp Glu Tyr Gly Gln Asp Val Asp Val Thr Thr Asn Pro Asp Glu 
625                 630                 635                 640 


Glu Leu Asp Gly Asp Asp Arg Tyr Asp Phe Glu Val Val Arg Cys Ile 
                645                 650                 655     


Cys Glu Val Gln Glu Glu Asn Asp Phe Met Ile Gln Cys Glu Glu Cys 
            660                 665                 670         


Gln Cys Trp Gln His Gly Val Cys Met Gly Leu Leu Glu Glu Asn Val 
        675                 680                 685             


Pro Glu Lys Tyr Thr Cys Tyr Val Cys Gln Asp Pro Pro Gly Gln Arg 
    690                 695                 700                 


Pro Gly Phe Lys Tyr Trp Tyr Asp Lys Glu Trp Leu Ser Arg Gly His 
705                 710                 715                 720 


Met His Gly Leu Ala Phe Leu Glu Glu Asn Tyr Ser His Gln Asn Ala 
                725                 730                 735     


Lys Lys Ile Val Ala Thr His Gln Leu Leu Gly Asp Val Gln Arg Val 
            740                 745                 750         


Ile Glu Val Leu His Gly Leu Gln Leu Lys Met Ser Ile Leu Gln Ser 
        755                 760                 765             


Arg Glu His Pro Asp Leu Pro Leu Trp Cys Gln Pro Trp Lys Gln His 
    770                 775                 780                 


Ser Gly Glu Gly Arg Ser His Phe Arg Asn Ile Pro Val Thr Asp Thr 
785                 790                 795                 800 


Arg Ser Lys Glu Glu Ala Pro Ser Tyr Arg Thr Leu Asn Gly Ala Val 
                805                 810                 815     


Glu Lys Pro Arg Pro Leu Ala Leu Pro Leu Pro Arg Ser Val Glu Glu 
            820                 825                 830         


Ser Tyr Ile Thr Ser Glu His Cys Tyr Gln Lys Pro Arg Ala Tyr Tyr 
        835                 840                 845             


Pro Ala Val Glu Gln Lys Leu Val Val Glu Thr Arg Gly Ser Ala Leu 
    850                 855                 860                 


Asp Asp Ala Val Asn Pro Leu His Glu Asn Gly Asp Asp Ser Leu Ser 
865                 870                 875                 880 


Pro Arg Leu Gly Trp Pro Leu Asp Gln Asp Arg Ser Lys Gly Asp Ser 
                885                 890                 895     


Asp Pro Lys Pro Gly Ser Pro Lys Val Lys Glu Tyr Val Ser Lys Lys 
            900                 905                 910         


Ala Leu Pro Glu Glu Ala Pro Ala Arg Lys Leu Leu Asp Arg Gly Gly 
        915                 920                 925             


Glu Gly Leu Leu Ser Ser Gln His Gln Trp Gln Phe Asn Leu Leu Thr 
    930                 935                 940                 


His Val Glu Ser Leu Gln Asp Glu Val Thr His Arg Met Asp Ser Ile 
945                 950                 955                 960 


Glu Lys Glu Leu Asp Val Leu Glu Ser Trp Leu Asp Tyr Thr Gly Glu 
                965                 970                 975     


Leu Glu Pro Pro Glu Pro Leu Ala Arg Leu Pro Gln Leu Lys His Cys 
            980                 985                 990         


Ile Lys Gln Leu Leu Met Asp Leu  Gly Lys Val Gln Gln  Ile Ala Leu 
        995                 1000                 1005             


Cys Cys  Ser Thr 
    1010         


<210>  2
<211>  2261
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Cys Trp Pro Gln Leu Arg Leu Leu Leu Trp Lys Asn Leu Thr 
1               5                   10                  15      


Phe Arg Arg Arg Gln Thr Cys Gln Leu Leu Leu Glu Val Ala Trp Pro 
            20                  25                  30          


Leu Phe Ile Phe Leu Ile Leu Ile Ser Val Arg Leu Ser Tyr Pro Pro 
        35                  40                  45              


Tyr Glu Gln His Glu Cys His Phe Pro Asn Lys Ala Met Pro Ser Ala 
    50                  55                  60                  


Gly Thr Leu Pro Trp Val Gln Gly Ile Ile Cys Asn Ala Asn Asn Pro 
65                  70                  75                  80  


Cys Phe Arg Tyr Pro Thr Pro Gly Glu Ala Pro Gly Val Val Gly Asn 
                85                  90                  95      


Phe Asn Lys Ser Ile Val Ala Arg Leu Phe Ser Asp Ala Arg Arg Leu 
            100                 105                 110         


Leu Leu Tyr Ser Gln Lys Asp Thr Ser Met Lys Asp Met Arg Lys Val 
        115                 120                 125             


Leu Arg Thr Leu Gln Gln Ile Lys Lys Ser Ser Ser Asn Leu Lys Leu 
    130                 135                 140                 


Gln Asp Phe Leu Val Asp Asn Glu Thr Phe Ser Gly Phe Leu Tyr His 
145                 150                 155                 160 


Asn Leu Ser Leu Pro Lys Ser Thr Val Asp Lys Met Leu Arg Ala Asp 
                165                 170                 175     


Val Ile Leu His Lys Val Phe Leu Gln Gly Tyr Gln Leu His Leu Thr 
            180                 185                 190         


Ser Leu Cys Asn Gly Ser Lys Ser Glu Glu Met Ile Gln Leu Gly Asp 
        195                 200                 205             


Gln Glu Val Ser Glu Leu Cys Gly Leu Pro Arg Glu Lys Leu Ala Ala 
    210                 215                 220                 


Ala Glu Arg Val Leu Arg Ser Asn Met Asp Ile Leu Lys Pro Ile Leu 
225                 230                 235                 240 


Arg Thr Leu Asn Ser Thr Ser Pro Phe Pro Ser Lys Glu Leu Ala Glu 
                245                 250                 255     


Ala Thr Lys Thr Leu Leu His Ser Leu Gly Thr Leu Ala Gln Glu Leu 
            260                 265                 270         


Phe Ser Met Arg Ser Trp Ser Asp Met Arg Gln Glu Val Met Phe Leu 
        275                 280                 285             


Thr Asn Val Asn Ser Ser Ser Ser Ser Thr Gln Ile Tyr Gln Ala Val 
    290                 295                 300                 


Ser Arg Ile Val Cys Gly His Pro Glu Gly Gly Gly Leu Lys Ile Lys 
305                 310                 315                 320 


Ser Leu Asn Trp Tyr Glu Asp Asn Asn Tyr Lys Ala Leu Phe Gly Gly 
                325                 330                 335     


Asn Gly Thr Glu Glu Asp Ala Glu Thr Phe Tyr Asp Asn Ser Thr Thr 
            340                 345                 350         


Pro Tyr Cys Asn Asp Leu Met Lys Asn Leu Glu Ser Ser Pro Leu Ser 
        355                 360                 365             


Arg Ile Ile Trp Lys Ala Leu Lys Pro Leu Leu Val Gly Lys Ile Leu 
    370                 375                 380                 


Tyr Thr Pro Asp Thr Pro Ala Thr Arg Gln Val Met Ala Glu Val Asn 
385                 390                 395                 400 


Lys Thr Phe Gln Glu Leu Ala Val Phe His Asp Leu Glu Gly Met Trp 
                405                 410                 415     


Glu Glu Leu Ser Pro Lys Ile Trp Thr Phe Met Glu Asn Ser Gln Glu 
            420                 425                 430         


Met Asp Leu Val Arg Met Leu Leu Asp Ser Arg Asp Asn Asp His Phe 
        435                 440                 445             


Trp Glu Gln Gln Leu Asp Gly Leu Asp Trp Thr Ala Gln Asp Ile Val 
    450                 455                 460                 


Ala Phe Leu Ala Lys His Pro Glu Asp Val Gln Ser Ser Asn Gly Ser 
465                 470                 475                 480 


Val Tyr Thr Trp Arg Glu Ala Phe Asn Glu Thr Asn Gln Ala Ile Arg 
                485                 490                 495     


Thr Ile Ser Arg Phe Met Glu Cys Val Asn Leu Asn Lys Leu Glu Pro 
            500                 505                 510         


Ile Ala Thr Glu Val Trp Leu Ile Asn Lys Ser Met Glu Leu Leu Asp 
        515                 520                 525             


Glu Arg Lys Phe Trp Ala Gly Ile Val Phe Thr Gly Ile Thr Pro Gly 
    530                 535                 540                 


Ser Ile Glu Leu Pro His His Val Lys Tyr Lys Ile Arg Met Asp Ile 
545                 550                 555                 560 


Asp Asn Val Glu Arg Thr Asn Lys Ile Lys Asp Gly Tyr Trp Asp Pro 
                565                 570                 575     


Gly Pro Arg Ala Asp Pro Phe Glu Asp Met Arg Tyr Val Trp Gly Gly 
            580                 585                 590         


Phe Ala Tyr Leu Gln Asp Val Val Glu Gln Ala Ile Ile Arg Val Leu 
        595                 600                 605             


Thr Gly Thr Glu Lys Lys Thr Gly Val Tyr Met Gln Gln Met Pro Tyr 
    610                 615                 620                 


Pro Cys Tyr Val Asp Asp Ile Phe Leu Arg Val Met Ser Arg Ser Met 
625                 630                 635                 640 


Pro Leu Phe Met Thr Leu Ala Trp Ile Tyr Ser Val Ala Val Ile Ile 
                645                 650                 655     


Lys Gly Ile Val Tyr Glu Lys Glu Ala Arg Leu Lys Glu Thr Met Arg 
            660                 665                 670         


Ile Met Gly Leu Asp Asn Ser Ile Leu Trp Phe Ser Trp Phe Ile Ser 
        675                 680                 685             


Ser Leu Ile Pro Leu Leu Val Ser Ala Gly Leu Leu Val Val Ile Leu 
    690                 695                 700                 


Lys Leu Gly Asn Leu Leu Pro Tyr Ser Asp Pro Ser Val Val Phe Val 
705                 710                 715                 720 


Phe Leu Ser Val Phe Ala Val Val Thr Ile Leu Gln Cys Phe Leu Ile 
                725                 730                 735     


Ser Thr Leu Phe Ser Arg Ala Asn Leu Ala Ala Ala Cys Gly Gly Ile 
            740                 745                 750         


Ile Tyr Phe Thr Leu Tyr Leu Pro Tyr Val Leu Cys Val Ala Trp Gln 
        755                 760                 765             


Asp Tyr Val Gly Phe Thr Leu Lys Ile Phe Ala Ser Leu Leu Ser Pro 
    770                 775                 780                 


Val Ala Phe Gly Phe Gly Cys Glu Tyr Phe Ala Leu Phe Glu Glu Gln 
785                 790                 795                 800 


Gly Ile Gly Val Gln Trp Asp Asn Leu Phe Glu Ser Pro Val Glu Glu 
                805                 810                 815     


Asp Gly Phe Asn Leu Thr Thr Ser Val Ser Met Met Leu Phe Asp Thr 
            820                 825                 830         


Phe Leu Tyr Gly Val Met Thr Trp Tyr Ile Glu Ala Val Phe Pro Gly 
        835                 840                 845             


Gln Tyr Gly Ile Pro Arg Pro Trp Tyr Phe Pro Cys Thr Lys Ser Tyr 
    850                 855                 860                 


Trp Phe Gly Glu Glu Ser Asp Glu Lys Ser His Pro Gly Ser Asn Gln 
865                 870                 875                 880 


Lys Arg Ile Ser Glu Ile Cys Met Glu Glu Glu Pro Thr His Leu Lys 
                885                 890                 895     


Leu Gly Val Ser Ile Gln Asn Leu Val Lys Val Tyr Arg Asp Gly Met 
            900                 905                 910         


Lys Val Ala Val Asp Gly Leu Ala Leu Asn Phe Tyr Glu Gly Gln Ile 
        915                 920                 925             


Thr Ser Phe Leu Gly His Asn Gly Ala Gly Lys Thr Thr Thr Met Ser 
    930                 935                 940                 


Ile Leu Thr Gly Leu Phe Pro Pro Thr Ser Gly Thr Ala Tyr Ile Leu 
945                 950                 955                 960 


Gly Lys Asp Ile Arg Ser Glu Met Ser Thr Ile Arg Gln Asn Leu Gly 
                965                 970                 975     


Val Cys Pro Gln His Asn Val Leu Phe Asp Met Leu Thr Val Glu Glu 
            980                 985                 990         


His Ile Trp Phe Tyr Ala Arg Leu  Lys Gly Leu Ser Glu  Lys His Val 
        995                 1000                 1005             


Lys Ala  Glu Met Glu Gln Met  Ala Leu Asp Val Gly  Leu Pro Ser 
    1010                 1015                 1020             


Ser Lys  Leu Lys Ser Lys Thr  Ser Gln Leu Ser Gly  Gly Met Gln 
    1025                 1030                 1035             


Arg Lys  Leu Ser Val Ala Leu  Ala Phe Val Gly Gly  Ser Lys Val 
    1040                 1045                 1050             


Val Ile  Leu Asp Glu Pro Thr  Ala Gly Val Asp Pro  Tyr Ser Arg 
    1055                 1060                 1065             


Arg Gly  Ile Trp Glu Leu Leu  Leu Lys Tyr Arg Gln  Gly Arg Thr 
    1070                 1075                 1080             


Ile Ile  Leu Ser Thr His His  Met Asp Glu Ala Asp  Val Leu Gly 
    1085                 1090                 1095             


Asp Arg  Ile Ala Ile Ile Ser  His Gly Lys Leu Cys  Cys Val Gly 
    1100                 1105                 1110             


Ser Ser  Leu Phe Leu Lys Asn  Gln Leu Gly Thr Gly  Tyr Tyr Leu 
    1115                 1120                 1125             


Thr Leu  Val Lys Lys Asp Val  Glu Ser Ser Leu Ser  Ser Cys Arg 
    1130                 1135                 1140             


Asn Ser  Ser Ser Thr Val Ser  Tyr Leu Lys Lys Glu  Asp Ser Val 
    1145                 1150                 1155             


Ser Gln  Ser Ser Ser Asp Ala  Gly Leu Gly Ser Asp  His Glu Ser 
    1160                 1165                 1170             


Asp Thr  Leu Thr Ile Asp Val  Ser Ala Ile Ser Asn  Leu Ile Arg 
    1175                 1180                 1185             


Lys His  Val Ser Glu Ala Arg  Leu Val Glu Asp Ile  Gly His Glu 
    1190                 1195                 1200             


Leu Thr  Tyr Val Leu Pro Tyr  Glu Ala Ala Lys Glu  Gly Ala Phe 
    1205                 1210                 1215             


Val Glu  Leu Phe His Glu Ile  Asp Asp Arg Leu Ser  Asp Leu Gly 
    1220                 1225                 1230             


Ile Ser  Ser Tyr Gly Ile Ser  Glu Thr Thr Leu Glu  Glu Ile Phe 
    1235                 1240                 1245             


Leu Lys  Val Ala Glu Glu Ser  Gly Val Asp Ala Glu  Thr Ser Asp 
    1250                 1255                 1260             


Gly Thr  Leu Pro Ala Arg Arg  Asn Arg Arg Ala Phe  Gly Asp Lys 
    1265                 1270                 1275             


Gln Ser  Cys Leu Arg Pro Phe  Thr Glu Asp Asp Ala  Ala Asp Pro 
    1280                 1285                 1290             


Asn Asp  Ser Asp Ile Asp Pro  Glu Ser Arg Glu Thr  Asp Leu Leu 
    1295                 1300                 1305             


Ser Gly  Met Asp Gly Lys Gly  Ser Tyr Gln Val Lys  Gly Trp Lys 
    1310                 1315                 1320             


Leu Thr  Gln Gln Gln Phe Val  Ala Leu Leu Trp Lys  Arg Leu Leu 
    1325                 1330                 1335             


Ile Ala  Arg Arg Ser Arg Lys  Gly Phe Phe Ala Gln  Ile Val Leu 
    1340                 1345                 1350             


Pro Ala  Val Phe Val Cys Ile  Ala Leu Val Phe Ser  Leu Ile Val 
    1355                 1360                 1365             


Pro Pro  Phe Gly Lys Tyr Pro  Ser Leu Glu Leu Gln  Pro Trp Met 
    1370                 1375                 1380             


Tyr Asn  Glu Gln Tyr Thr Phe  Val Ser Asn Asp Ala  Pro Glu Asp 
    1385                 1390                 1395             


Thr Gly  Thr Leu Glu Leu Leu  Asn Ala Leu Thr Lys  Asp Pro Gly 
    1400                 1405                 1410             


Phe Gly  Thr Arg Cys Met Glu  Gly Asn Pro Ile Pro  Asp Thr Pro 
    1415                 1420                 1425             


Cys Gln  Ala Gly Glu Glu Glu  Trp Thr Thr Ala Pro  Val Pro Gln 
    1430                 1435                 1440             


Thr Ile  Met Asp Leu Phe Gln  Asn Gly Asn Trp Thr  Met Gln Asn 
    1445                 1450                 1455             


Pro Ser  Pro Ala Cys Gln Cys  Ser Ser Asp Lys Ile  Lys Lys Met 
    1460                 1465                 1470             


Leu Pro  Val Cys Pro Pro Gly  Ala Gly Gly Leu Pro  Pro Pro Gln 
    1475                 1480                 1485             


Arg Lys  Gln Asn Thr Ala Asp  Ile Leu Gln Asp Leu  Thr Gly Arg 
    1490                 1495                 1500             


Asn Ile  Ser Asp Tyr Leu Val  Lys Thr Tyr Val Gln  Ile Ile Ala 
    1505                 1510                 1515             


Lys Ser  Leu Lys Asn Lys Ile  Trp Val Asn Glu Phe  Arg Tyr Gly 
    1520                 1525                 1530             


Gly Phe  Ser Leu Gly Val Ser  Asn Thr Gln Ala Leu  Pro Pro Ser 
    1535                 1540                 1545             


Gln Glu  Val Asn Asp Ala Ile  Lys Gln Met Lys Lys  His Leu Lys 
    1550                 1555                 1560             


Leu Ala  Lys Asp Ser Ser Ala  Asp Arg Phe Leu Asn  Ser Leu Gly 
    1565                 1570                 1575             


Arg Phe  Met Thr Gly Leu Asp  Thr Lys Asn Asn Val  Lys Val Trp 
    1580                 1585                 1590             


Phe Asn  Asn Lys Gly Trp His  Ala Ile Ser Ser Phe  Leu Asn Val 
    1595                 1600                 1605             


Ile Asn  Asn Ala Ile Leu Arg  Ala Asn Leu Gln Lys  Gly Glu Asn 
    1610                 1615                 1620             


Pro Ser  His Tyr Gly Ile Thr  Ala Phe Asn His Pro  Leu Asn Leu 
    1625                 1630                 1635             


Thr Lys  Gln Gln Leu Ser Glu  Val Ala Leu Met Thr  Thr Ser Val 
    1640                 1645                 1650             


Asp Val  Leu Val Ser Ile Cys  Val Ile Phe Ala Met  Ser Phe Val 
    1655                 1660                 1665             


Pro Ala  Ser Phe Val Val Phe  Leu Ile Gln Glu Arg  Val Ser Lys 
    1670                 1675                 1680             


Ala Lys  His Leu Gln Phe Ile  Ser Gly Val Lys Pro  Val Ile Tyr 
    1685                 1690                 1695             


Trp Leu  Ser Asn Phe Val Trp  Asp Met Cys Asn Tyr  Val Val Pro 
    1700                 1705                 1710             


Ala Thr  Leu Val Ile Ile Ile  Phe Ile Cys Phe Gln  Gln Lys Ser 
    1715                 1720                 1725             


Tyr Val  Ser Ser Thr Asn Leu  Pro Val Leu Ala Leu  Leu Leu Leu 
    1730                 1735                 1740             


Leu Tyr  Gly Trp Ser Ile Thr  Pro Leu Met Tyr Pro  Ala Ser Phe 
    1745                 1750                 1755             


Val Phe  Lys Ile Pro Ser Thr  Ala Tyr Val Val Leu  Thr Ser Val 
    1760                 1765                 1770             


Asn Leu  Phe Ile Gly Ile Asn  Gly Ser Val Ala Thr  Phe Val Leu 
    1775                 1780                 1785             


Glu Leu  Phe Thr Asp Asn Lys  Leu Asn Asn Ile Asn  Asp Ile Leu 
    1790                 1795                 1800             


Lys Ser  Val Phe Leu Ile Phe  Pro His Phe Cys Leu  Gly Arg Gly 
    1805                 1810                 1815             


Leu Ile  Asp Met Val Lys Asn  Gln Ala Met Ala Asp  Ala Leu Glu 
    1820                 1825                 1830             


Arg Phe  Gly Glu Asn Arg Phe  Val Ser Pro Leu Ser  Trp Asp Leu 
    1835                 1840                 1845             


Val Gly  Arg Asn Leu Phe Ala  Met Ala Val Glu Gly  Val Val Phe 
    1850                 1855                 1860             


Phe Leu  Ile Thr Val Leu Ile  Gln Tyr Arg Phe Phe  Ile Arg Pro 
    1865                 1870                 1875             


Arg Pro  Val Asn Ala Lys Leu  Ser Pro Leu Asn Asp  Glu Asp Glu 
    1880                 1885                 1890             


Asp Val  Arg Arg Glu Arg Gln  Arg Ile Leu Asp Gly  Gly Gly Gln 
    1895                 1900                 1905             


Asn Asp  Ile Leu Glu Ile Lys  Glu Leu Thr Lys Ile  Tyr Arg Arg 
    1910                 1915                 1920             


Lys Arg  Lys Pro Ala Val Asp  Arg Ile Cys Val Gly  Ile Pro Pro 
    1925                 1930                 1935             


Gly Glu  Cys Phe Gly Leu Leu  Gly Val Asn Gly Ala  Gly Lys Ser 
    1940                 1945                 1950             


Ser Thr  Phe Lys Met Leu Thr  Gly Asp Thr Thr Val  Thr Arg Gly 
    1955                 1960                 1965             


Asp Ala  Phe Leu Asn Lys Asn  Ser Ile Leu Ser Asn  Ile His Glu 
    1970                 1975                 1980             


Val His  Gln Asn Met Gly Tyr  Cys Pro Gln Phe Asp  Ala Ile Thr 
    1985                 1990                 1995             


Glu Leu  Leu Thr Gly Arg Glu  His Val Glu Phe Phe  Ala Leu Leu 
    2000                 2005                 2010             


Arg Gly  Val Pro Glu Lys Glu  Val Gly Lys Val Gly  Glu Trp Ala 
    2015                 2020                 2025             


Ile Arg  Lys Leu Gly Leu Val  Lys Tyr Gly Glu Lys  Tyr Ala Gly 
    2030                 2035                 2040             


Asn Tyr  Ser Gly Gly Asn Lys  Arg Lys Leu Ser Thr  Ala Met Ala 
    2045                 2050                 2055             


Leu Ile  Gly Gly Pro Pro Val  Val Phe Leu Asp Glu  Pro Thr Thr 
    2060                 2065                 2070             


Gly Met  Asp Pro Lys Ala Arg  Arg Phe Leu Trp Asn  Cys Ala Leu 
    2075                 2080                 2085             


Ser Val  Val Lys Glu Gly Arg  Ser Val Val Leu Thr  Ser His Ser 
    2090                 2095                 2100             


Met Glu  Glu Cys Glu Ala Leu  Cys Thr Arg Met Ala  Ile Met Val 
    2105                 2110                 2115             


Asn Gly  Arg Phe Arg Cys Leu  Gly Ser Val Gln His  Leu Lys Asn 
    2120                 2125                 2130             


Arg Phe  Gly Asp Gly Tyr Thr  Ile Val Val Arg Ile  Ala Gly Ser 
    2135                 2140                 2145             


Asn Pro  Asp Leu Lys Pro Val  Gln Asp Phe Phe Gly  Leu Ala Phe 
    2150                 2155                 2160             


Pro Gly  Ser Val Leu Lys Glu  Lys His Arg Asn Met  Leu Gln Tyr 
    2165                 2170                 2175             


Gln Leu  Pro Ser Ser Leu Ser  Ser Leu Ala Arg Ile  Phe Ser Ile 
    2180                 2185                 2190             


Leu Ser  Gln Ser Lys Lys Arg  Leu His Ile Glu Asp  Tyr Ser Val 
    2195                 2200                 2205             


Ser Gln  Thr Thr Leu Asp Gln  Val Phe Val Asn Phe  Ala Lys Asp 
    2210                 2215                 2220             


Gln Ser  Asp Asp Asp His Leu  Lys Asp Leu Ser Leu  His Lys Asn 
    2225                 2230                 2235             


Gln Thr  Val Val Asp Val Ala  Val Leu Thr Ser Phe  Leu Gln Asp 
    2240                 2245                 2250             


Glu Lys  Val Lys Glu Ser Tyr  Val 
    2255                 2260     


<210>  3
<211>  749
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ala His Arg Lys Leu Glu Ser Val Gly Ser Gly Met Leu Asp His 
1               5                   10                  15      


Arg Val Arg Pro Gly Pro Val Pro His Ser Gln Glu Pro Glu Ser Glu 
            20                  25                  30          


Asp Met Glu Leu Pro Leu Glu Gly Tyr Val Pro Glu Gly Leu Glu Leu 
        35                  40                  45              


Ala Ala Leu Arg Pro Glu Ser Pro Ala Pro Glu Glu Gln Glu Cys His 
    50                  55                  60                  


Asn His Ser Pro Asp Gly Asp Ser Ser Ser Asp Tyr Val Asn Asn Thr 
65                  70                  75                  80  


Ser Glu Glu Glu Asp Tyr Asp Glu Gly Leu Pro Glu Glu Glu Glu Gly 
                85                  90                  95      


Ile Thr Tyr Tyr Ile Arg Tyr Cys Pro Glu Asp Asp Ser Tyr Leu Glu 
            100                 105                 110         


Gly Met Asp Cys Asn Gly Glu Glu Tyr Leu Ala His Ser Ala His Pro 
        115                 120                 125             


Val Asp Thr Asp Glu Cys Gln Glu Ala Val Glu Glu Trp Thr Asp Ser 
    130                 135                 140                 


Ala Gly Pro His Pro His Gly His Glu Ala Glu Gly Ser Gln Asp Tyr 
145                 150                 155                 160 


Pro Asp Gly Gln Leu Pro Ile Pro Glu Asp Glu Pro Ser Val Leu Glu 
                165                 170                 175     


Ala His Asp Gln Glu Glu Asp Gly His Tyr Cys Ala Ser Lys Glu Gly 
            180                 185                 190         


Tyr Gln Asp Tyr Tyr Pro Glu Glu Ala Asn Gly Asn Thr Gly Ala Ser 
        195                 200                 205             


Pro Tyr Arg Leu Arg Arg Gly Asp Gly Asp Leu Glu Asp Gln Glu Glu 
    210                 215                 220                 


Asp Ile Asp Gln Ile Val Ala Glu Ile Lys Met Ser Leu Ser Met Thr 
225                 230                 235                 240 


Ser Ile Thr Ser Ala Ser Glu Ala Ser Pro Glu His Gly Pro Glu Pro 
                245                 250                 255     


Gly Pro Glu Asp Ser Val Glu Ala Cys Pro Pro Ile Lys Ala Ser Cys 
            260                 265                 270         


Ser Pro Ser Arg His Glu Ala Arg Pro Lys Ser Leu Asn Leu Leu Pro 
        275                 280                 285             


Glu Ala Lys His Pro Gly Asp Pro Gln Arg Gly Phe Lys Pro Lys Thr 
    290                 295                 300                 


Arg Thr Pro Glu Glu Arg Leu Lys Trp Pro His Glu Gln Val Cys Asn 
305                 310                 315                 320 


Gly Leu Glu Gln Pro Arg Lys Gln Gln Arg Ser Asp Leu Asn Gly Pro 
                325                 330                 335     


Val Asp Asn Asn Asn Ile Pro Glu Thr Lys Lys Val Ala Ser Phe Pro 
            340                 345                 350         


Ser Phe Val Ala Val Pro Gly Pro Cys Glu Pro Glu Asp Leu Ile Asp 
        355                 360                 365             


Gly Ile Ile Phe Ala Ala Asn Tyr Leu Gly Ser Thr Gln Leu Leu Ser 
    370                 375                 380                 


Glu Arg Asn Pro Ser Lys Asn Ile Arg Met Met Gln Ala Gln Glu Ala 
385                 390                 395                 400 


Val Ser Arg Val Lys Arg Met Gln Lys Ala Ala Lys Ile Lys Lys Lys 
                405                 410                 415     


Ala Asn Ser Glu Gly Asp Ala Gln Thr Leu Thr Glu Val Asp Leu Phe 
            420                 425                 430         


Ile Ser Thr Gln Arg Ile Lys Val Leu Asn Ala Asp Thr Gln Glu Thr 
        435                 440                 445             


Met Met Asp His Ala Leu Arg Thr Ile Ser Tyr Ile Ala Asp Ile Gly 
    450                 455                 460                 


Asn Ile Val Val Leu Met Ala Arg Arg Arg Met Pro Arg Ser Ala Ser 
465                 470                 475                 480 


Gln Asp Cys Ile Glu Thr Thr Pro Gly Ala Gln Glu Gly Lys Lys Gln 
                485                 490                 495     


Tyr Lys Met Ile Cys His Val Phe Glu Ser Glu Asp Ala Gln Leu Ile 
            500                 505                 510         


Ala Gln Ser Ile Gly Gln Ala Phe Ser Val Ala Tyr Gln Glu Phe Leu 
        515                 520                 525             


Arg Ala Asn Gly Ile Asn Pro Glu Asp Leu Ser Gln Lys Glu Tyr Ser 
    530                 535                 540                 


Asp Ile Ile Asn Thr Gln Glu Met Tyr Asn Asp Asp Leu Ile His Phe 
545                 550                 555                 560 


Ser Asn Ser Glu Asn Cys Lys Glu Leu Gln Leu Glu Lys His Lys Gly 
                565                 570                 575     


Glu Ile Leu Gly Val Val Val Val Glu Ser Gly Trp Gly Ser Ile Leu 
            580                 585                 590         


Pro Thr Val Ile Leu Ala Asn Met Met Asn Gly Gly Pro Ala Ala Arg 
        595                 600                 605             


Ser Gly Lys Leu Ser Ile Gly Asp Gln Ile Met Ser Ile Asn Gly Thr 
    610                 615                 620                 


Ser Leu Val Gly Leu Pro Leu Ala Thr Cys Gln Gly Ile Ile Lys Gly 
625                 630                 635                 640 


Leu Lys Asn Gln Thr Gln Val Lys Leu Asn Ile Val Ser Cys Pro Pro 
                645                 650                 655     


Val Thr Thr Val Leu Ile Lys Arg Pro Asp Leu Lys Tyr Gln Leu Gly 
            660                 665                 670         


Phe Ser Val Gln Asn Gly Ile Ile Cys Ser Leu Met Arg Gly Gly Ile 
        675                 680                 685             


Ala Glu Arg Gly Gly Val Arg Val Gly His Arg Ile Ile Glu Ile Asn 
    690                 695                 700                 


Gly Gln Ser Val Val Ala Thr Ala His Glu Lys Ile Val Gln Ala Leu 
705                 710                 715                 720 


Ser Asn Ser Val Gly Glu Ile His Met Lys Thr Met Pro Ala Ala Met 
                725                 730                 735     


Phe Arg Leu Leu Thr Gly Gln Glu Thr Pro Leu Tyr Ile 
            740                 745                 


<210>  4
<211>  1032
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Phe Thr Asn Tyr Ser Ser Leu Asn Arg Ala Gln Leu Thr Phe 
1               5                   10                  15      


Glu Tyr Leu His Thr Asn Ser Thr Thr His Glu Phe Leu Phe Gly Ala 
            20                  25                  30          


Leu Ala Glu Leu Val Asp Asn Ala Arg Asp Ala Asp Ala Thr Arg Ile 
        35                  40                  45              


Asp Ile Tyr Ala Glu Arg Arg Glu Asp Leu Arg Gly Gly Phe Met Leu 
    50                  55                  60                  


Cys Phe Leu Asp Asp Gly Ala Gly Met Asp Pro Ser Asp Ala Ala Ser 
65                  70                  75                  80  


Val Ile Gln Phe Gly Lys Ser Ala Lys Arg Thr Pro Glu Ser Thr Gln 
                85                  90                  95      


Ile Gly Gln Tyr Gly Asn Gly Leu Lys Ser Gly Ser Met Arg Ile Gly 
            100                 105                 110         


Lys Asp Phe Ile Leu Phe Thr Lys Lys Glu Asp Thr Met Thr Cys Leu 
        115                 120                 125             


Phe Leu Ser Arg Thr Phe His Glu Glu Glu Gly Ile Asp Glu Val Ile 
    130                 135                 140                 


Val Pro Leu Pro Thr Trp Asn Ala Arg Thr Arg Glu Pro Val Thr Asp 
145                 150                 155                 160 


Asn Val Glu Lys Phe Ala Ile Glu Thr Glu Leu Ile Tyr Lys Tyr Ser 
                165                 170                 175     


Pro Phe Arg Thr Glu Glu Glu Val Met Thr Gln Phe Met Lys Ile Pro 
            180                 185                 190         


Gly Asp Ser Gly Thr Leu Val Ile Ile Phe Asn Leu Lys Leu Met Asp 
        195                 200                 205             


Asn Gly Glu Pro Glu Leu Asp Ile Ile Ser Asn Pro Arg Asp Ile Gln 
    210                 215                 220                 


Met Ala Glu Thr Ser Pro Glu Gly Thr Lys Pro Glu Arg Arg Ser Phe 
225                 230                 235                 240 


Arg Ala Tyr Ala Ala Val Leu Tyr Ile Asp Pro Arg Met Arg Ile Phe 
                245                 250                 255     


Ile His Gly His Lys Val Gln Thr Lys Arg Leu Ser Cys Cys Leu Tyr 
            260                 265                 270         


Lys Pro Arg Met Tyr Lys Tyr Thr Ser Ser Arg Phe Lys Thr Arg Ala 
        275                 280                 285             


Glu Gln Glu Val Lys Lys Ala Glu His Val Ala Arg Ile Ala Glu Glu 
    290                 295                 300                 


Lys Ala Arg Glu Ala Glu Ser Lys Ala Arg Thr Leu Glu Val Arg Leu 
305                 310                 315                 320 


Gly Gly Asp Leu Thr Arg Asp Ser Arg Val Met Leu Arg Gln Val Gln 
                325                 330                 335     


Asn Arg Ala Ile Thr Leu Arg Arg Glu Ala Asp Val Lys Lys Arg Ile 
            340                 345                 350         


Lys Glu Ala Lys Gln Arg Ala Leu Lys Glu Pro Lys Glu Leu Asn Phe 
        355                 360                 365             


Val Phe Gly Val Asn Ile Glu His Arg Asp Leu Asp Gly Met Phe Ile 
    370                 375                 380                 


Tyr Asn Cys Ser Arg Leu Ile Lys Met Tyr Glu Lys Val Gly Pro Gln 
385                 390                 395                 400 


Leu Glu Gly Gly Met Ala Cys Gly Gly Val Val Gly Val Val Asp Val 
                405                 410                 415     


Pro Tyr Leu Val Leu Glu Pro Thr His Asn Lys Gln Asp Phe Ala Asp 
            420                 425                 430         


Ala Lys Glu Tyr Arg His Leu Leu Arg Ala Met Gly Glu His Leu Ala 
        435                 440                 445             


Gln Tyr Trp Lys Asp Ile Ala Ile Ala Gln Arg Gly Ile Ile Lys Phe 
    450                 455                 460                 


Trp Asp Glu Phe Gly Tyr Leu Ser Ala Asn Trp Asn Gln Pro Pro Ser 
465                 470                 475                 480 


Ser Glu Leu Arg Tyr Lys Arg Arg Arg Ala Met Glu Ile Pro Thr Thr 
                485                 490                 495     


Ile Gln Cys Asp Leu Cys Leu Lys Trp Arg Thr Leu Pro Phe Gln Leu 
            500                 505                 510         


Ser Ser Val Glu Lys Asp Tyr Pro Asp Thr Trp Val Cys Ser Met Asn 
        515                 520                 525             


Pro Asp Pro Glu Gln Asp Arg Cys Glu Ala Ser Glu Gln Lys Gln Lys 
    530                 535                 540                 


Val Pro Leu Gly Thr Phe Arg Lys Asp Met Lys Thr Gln Glu Glu Lys 
545                 550                 555                 560 


Gln Lys Gln Leu Thr Glu Lys Ile Arg Gln Gln Gln Glu Lys Leu Glu 
                565                 570                 575     


Ala Leu Gln Lys Thr Thr Pro Ile Arg Ser Gln Ala Asp Leu Lys Lys 
            580                 585                 590         


Leu Pro Leu Glu Val Thr Thr Arg Pro Ser Thr Glu Glu Pro Val Arg 
        595                 600                 605             


Arg Pro Gln Arg Pro Arg Ser Pro Pro Leu Pro Ala Val Ile Arg Asn 
    610                 615                 620                 


Ala Pro Ser Arg Pro Pro Ser Leu Pro Thr Pro Arg Pro Ala Ser Gln 
625                 630                 635                 640 


Pro Arg Lys Ala Pro Val Ile Ser Ser Thr Pro Lys Leu Pro Ala Leu 
                645                 650                 655     


Ala Ala Arg Glu Glu Ala Ser Thr Ser Arg Leu Leu Gln Pro Pro Glu 
            660                 665                 670         


Ala Pro Arg Lys Pro Ala Asn Thr Leu Val Lys Thr Ala Ser Arg Pro 
        675                 680                 685             


Ala Pro Leu Val Gln Gln Leu Ser Pro Ser Leu Leu Pro Asn Ser Lys 
    690                 695                 700                 


Ser Pro Arg Glu Val Pro Ser Pro Lys Val Ile Lys Thr Pro Val Val 
705                 710                 715                 720 


Lys Lys Thr Glu Ser Pro Ile Lys Leu Ser Pro Ala Thr Pro Ser Arg 
                725                 730                 735     


Lys Arg Ser Val Ala Val Ser Asp Glu Glu Glu Val Glu Glu Glu Ala 
            740                 745                 750         


Glu Arg Arg Lys Glu Arg Cys Lys Arg Gly Arg Phe Val Val Lys Glu 
        755                 760                 765             


Glu Lys Lys Asp Ser Asn Glu Leu Ser Asp Ser Ala Gly Glu Glu Asp 
    770                 775                 780                 


Ser Ala Asp Leu Lys Arg Ala Gln Lys Asp Lys Gly Leu His Val Glu 
785                 790                 795                 800 


Val Arg Val Asn Arg Glu Trp Tyr Thr Gly Arg Val Thr Ala Val Glu 
                805                 810                 815     


Val Gly Lys His Val Val Arg Trp Lys Val Lys Phe Asp Tyr Val Pro 
            820                 825                 830         


Thr Asp Thr Thr Pro Arg Asp Arg Trp Val Glu Lys Gly Ser Glu Asp 
        835                 840                 845             


Val Arg Leu Met Lys Pro Pro Ser Pro Glu His Gln Ser Leu Asp Thr 
    850                 855                 860                 


Gln Gln Glu Gly Gly Glu Glu Glu Val Gly Pro Val Ala Gln Gln Ala 
865                 870                 875                 880 


Ile Ala Val Ala Glu Pro Ser Thr Ser Glu Cys Leu Arg Ile Glu Pro 
                885                 890                 895     


Asp Thr Thr Ala Leu Ser Thr Asn His Glu Thr Ile Asp Leu Leu Val 
            900                 905                 910         


Gln Ile Leu Arg Asn Cys Leu Arg Tyr Phe Leu Pro Pro Ser Phe Pro 
        915                 920                 925             


Ile Ser Lys Lys Gln Leu Ser Ala Met Asn Ser Asp Glu Leu Ile Ser 
    930                 935                 940                 


Phe Pro Leu Lys Glu Tyr Phe Lys Gln Tyr Glu Val Gly Leu Gln Asn 
945                 950                 955                 960 


Leu Cys Asn Ser Tyr Gln Ser Arg Ala Asp Ser Arg Ala Lys Ala Ser 
                965                 970                 975     


Glu Glu Ser Leu Arg Thr Ser Glu Arg Lys Leu Arg Glu Thr Glu Glu 
            980                 985                 990         


Lys Leu Gln Lys Leu Arg Thr Asn  Ile Val Ala Leu Leu  Gln Lys Val 
        995                 1000                 1005             


Gln Glu  Asp Ile Asp Ile Asn  Thr Asp Asp Glu Leu  Asp Ala Tyr 
    1010                 1015                 1020             


Ile Glu  Asp Leu Ile Thr Lys  Gly Asp 
    1025                 1030         


<210>  5
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Thr Glu Ala Asp Val Asn Pro Lys Ala Tyr Pro Leu Ala Asp Ala 
1               5                   10                  15      


His Leu Thr Lys Lys Leu Leu Asp Leu Val Gln Gln Ser Cys Asn Tyr 
            20                  25                  30          


Lys Gln Leu Arg Lys Gly Ala Asn Glu Ala Thr Lys Thr Leu Asn Arg 
        35                  40                  45              


Gly Ile Ser Glu Phe Ile Val Met Ala Ala Asp Ala Glu Pro Leu Glu 
    50                  55                  60                  


Ile Ile Leu His Leu Pro Leu Leu Cys Glu Asp Lys Asn Val Pro Tyr 
65                  70                  75                  80  


Val Phe Val Arg Ser Lys Gln Ala Leu Gly Arg Ala Cys Gly Val Ser 
                85                  90                  95      


Arg Pro Val Ile Ala Cys Ser Val Thr Ile Lys Glu Gly Ser Gln Leu 
            100                 105                 110         


Lys Gln Gln Ile Gln Ser Ile Gln Gln Ser Ile Glu Arg Leu Leu Val 
        115                 120                 125             


<210>  6
<211>  259
<212>  PRT
<213>  Homo sapiens

<400>  6

Met His Lys Leu Lys Ser Ser Gln Lys Asp Lys Val Arg Gln Phe Met 
1               5                   10                  15      


Ala Cys Thr Gln Ala Gly Glu Arg Thr Ala Ile Tyr Cys Leu Thr Gln 
            20                  25                  30          


Asn Glu Trp Arg Leu Asp Glu Ala Thr Asp Ser Phe Phe Gln Asn Pro 
        35                  40                  45              


Asp Ser Leu His Arg Glu Ser Met Arg Asn Ala Val Asp Lys Lys Lys 
    50                  55                  60                  


Leu Glu Arg Leu Tyr Gly Arg Tyr Lys Asp Pro Gln Asp Glu Asn Lys 
65                  70                  75                  80  


Ile Gly Val Asp Gly Ile Gln Gln Phe Cys Asp Asp Leu Ser Leu Asp 
                85                  90                  95      


Pro Ala Ser Ile Ser Val Leu Val Ile Ala Trp Lys Phe Arg Ala Ala 
            100                 105                 110         


Thr Gln Cys Glu Phe Ser Arg Lys Glu Phe Leu Asp Gly Met Thr Glu 
        115                 120                 125             


Leu Gly Cys Asp Ser Met Glu Lys Leu Lys Ala Leu Leu Pro Arg Leu 
    130                 135                 140                 


Glu Gln Glu Leu Lys Asp Thr Ala Lys Phe Lys Asp Phe Tyr Gln Phe 
145                 150                 155                 160 


Thr Phe Thr Phe Ala Lys Asn Pro Gly Gln Lys Gly Leu Asp Leu Glu 
                165                 170                 175     


Met Ala Val Ala Tyr Trp Lys Leu Val Leu Ser Gly Arg Phe Lys Phe 
            180                 185                 190         


Leu Asp Leu Trp Asn Thr Phe Leu Met Glu His His Lys Arg Ser Ile 
        195                 200                 205             


Pro Arg Asp Thr Trp Asn Leu Leu Leu Asp Phe Gly Asn Met Ile Ala 
    210                 215                 220                 


Asp Asp Met Ser Asn Tyr Asp Glu Glu Gly Ala Trp Pro Val Leu Ile 
225                 230                 235                 240 


Asp Asp Phe Val Glu Tyr Ala Arg Pro Val Val Thr Gly Gly Lys Arg 
                245                 250                 255     


Ser Leu Phe 
            


<210>  7
<211>  160
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Ser Asp Asn Asp Asp Ile Glu Val Glu Ser Asp Glu Glu Gln Pro 
1               5                   10                  15      


Arg Phe Gln Ser Ala Ala Asp Lys Arg Ala His His Asn Ala Leu Glu 
            20                  25                  30          


Arg Lys Arg Arg Asp His Ile Lys Asp Ser Phe His Ser Leu Arg Asp 
        35                  40                  45              


Ser Val Pro Ser Leu Gln Gly Glu Lys Ala Ser Arg Ala Gln Ile Leu 
    50                  55                  60                  


Asp Lys Ala Thr Glu Tyr Ile Gln Tyr Met Arg Arg Lys Asn His Thr 
65                  70                  75                  80  


His Gln Gln Asp Ile Asp Asp Leu Lys Arg Gln Asn Ala Leu Leu Glu 
                85                  90                  95      


Gln Gln Val Arg Ala Leu Glu Lys Ala Arg Ser Ser Ala Gln Leu Gln 
            100                 105                 110         


Thr Asn Tyr Pro Ser Ser Asp Asn Ser Leu Tyr Thr Asn Ala Lys Gly 
        115                 120                 125             


Ser Thr Ile Ser Ala Phe Asp Gly Gly Ser Asp Ser Ser Ser Glu Ser 
    130                 135                 140                 


Glu Pro Glu Glu Pro Gln Ser Arg Lys Lys Leu Arg Met Glu Ala Ser 
145                 150                 155                 160 


<210>  8
<211>  702
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ala Asp Ser Gly Leu Leu Leu Lys Arg Gly Ser Cys Arg Ser Thr 
1               5                   10                  15      


Trp Leu Arg Val Arg Lys Ala Arg Pro Gln Leu Ile Leu Ser Arg Arg 
            20                  25                  30          


Pro Arg Arg Arg Leu Gly Ser Leu Arg Trp Cys Gly Arg Arg Arg Leu 
        35                  40                  45              


Arg Trp Arg Leu Leu Gln Ala Gln Ala Ser Gly Val Asp Trp Arg Glu 
    50                  55                  60                  


Gly Ala Arg Gln Val Ser Arg Ala Ala Ala Ala Arg Arg Pro Asn Thr 
65                  70                  75                  80  


Ala Thr Pro Ser Pro Ile Pro Ser Pro Thr Pro Ala Ser Glu Pro Glu 
                85                  90                  95      


Ser Glu Pro Glu Leu Glu Ser Ala Ser Ser Cys His Arg Pro Leu Leu 
            100                 105                 110         


Ile Pro Pro Val Arg Pro Val Gly Pro Gly Arg Ala Leu Leu Leu Leu 
        115                 120                 125             


Pro Val Glu Gln Gly Phe Thr Phe Ser Gly Ile Cys Arg Val Thr Cys 
    130                 135                 140                 


Leu Tyr Gly Gln Val Gln Val Phe Gly Phe Thr Ile Ser Gln Gly Gln 
145                 150                 155                 160 


Pro Ala Gln Asp Ile Phe Ser Val Tyr Thr His Ser Cys Leu Ser Ile 
                165                 170                 175     


His Ala Leu His Tyr Ser Gln Pro Glu Lys Ser Lys Lys Glu Leu Lys 
            180                 185                 190         


Arg Glu Ala Arg Asn Leu Leu Lys Ser His Leu Asn Leu Asp Asp Arg 
        195                 200                 205             


Arg Trp Ser Met Gln Asn Phe Ser Pro Gln Cys Ser Ile Val Leu Leu 
    210                 215                 220                 


Glu His Leu Lys Thr Ala Thr Val Asn Phe Ile Thr Ser Tyr Pro Gly 
225                 230                 235                 240 


Ser Ser Tyr Ile Phe Val Gln Glu Ser Pro Thr Pro Gln Ile Lys Pro 
                245                 250                 255     


Glu Tyr Leu Ala Leu Arg Ser Val Gly Ile Arg Arg Glu Lys Lys Arg 
            260                 265                 270         


Lys Gly Leu Gln Leu Thr Glu Ser Thr Leu Ser Ala Leu Glu Glu Leu 
        275                 280                 285             


Val Asn Val Ser Cys Glu Glu Val Asp Gly Cys Pro Val Ile Leu Val 
    290                 295                 300                 


Cys Gly Ser Gln Asp Val Gly Lys Ser Thr Phe Asn Arg Tyr Leu Ile 
305                 310                 315                 320 


Asn His Leu Leu Asn Ser Leu Pro Cys Val Asp Tyr Leu Glu Cys Asp 
                325                 330                 335     


Leu Gly Gln Thr Glu Phe Thr Pro Pro Gly Cys Ile Ser Leu Leu Asn 
            340                 345                 350         


Ile Thr Glu Pro Val Leu Gly Pro Pro Phe Thr His Leu Arg Thr Pro 
        355                 360                 365             


Gln Lys Met Val Tyr Tyr Gly Lys Pro Ser Cys Lys Asn Asn Tyr Glu 
    370                 375                 380                 


Asn Tyr Ile Asp Ile Val Lys Tyr Val Phe Ser Ala Tyr Lys Arg Glu 
385                 390                 395                 400 


Ser Pro Leu Ile Val Asn Thr Met Gly Trp Val Ser Asp Gln Gly Leu 
                405                 410                 415     


Leu Leu Leu Ile Asp Leu Ile Arg Leu Leu Ser Pro Ser His Val Val 
            420                 425                 430         


Gln Phe Arg Ser Asp His Ser Lys Tyr Met Pro Asp Leu Thr Pro Gln 
        435                 440                 445             


Tyr Val Asp Asp Met Asp Gly Leu Tyr Thr Lys Ser Lys Thr Lys Met 
    450                 455                 460                 


Arg Asn Arg Arg Phe Arg Leu Ala Ala Phe Ala Asp Ala Leu Glu Phe 
465                 470                 475                 480 


Ala Asp Glu Glu Lys Glu Ser Pro Val Glu Phe Thr Gly His Lys Leu 
                485                 490                 495     


Ile Gly Val Tyr Thr Asp Phe Ala Phe Arg Ile Thr Pro Arg Asn Arg 
            500                 505                 510         


Glu Ser His Asn Lys Ile Leu Arg Asp Leu Ser Ile Leu Ser Tyr Leu 
        515                 520                 525             


Ser Gln Leu Gln Pro Pro Met Pro Lys Pro Leu Ser Pro Leu His Ser 
    530                 535                 540                 


Leu Thr Pro Tyr Gln Val Pro Phe Asn Ala Val Ala Leu Arg Ile Thr 
545                 550                 555                 560 


His Ser Asp Val Ala Pro Thr His Ile Leu Tyr Ala Val Asn Ala Ser 
                565                 570                 575     


Trp Val Gly Leu Cys Lys Ile Gln Asp Asp Val Arg Gly Tyr Thr Asn 
            580                 585                 590         


Gly Pro Ile Leu Leu Ala Gln Thr Pro Ile Cys Asp Cys Leu Gly Phe 
        595                 600                 605             


Gly Ile Cys Arg Gly Ile Asp Met Glu Lys Arg Leu Tyr His Ile Leu 
    610                 615                 620                 


Thr Pro Val Pro Pro Glu Glu Leu Arg Thr Val Asn Cys Leu Leu Val 
625                 630                 635                 640 


Gly Ala Ile Ala Ile Pro His Cys Val Leu Lys Cys Gln Arg Gly Ile 
                645                 650                 655     


Glu Gly Thr Val Pro Tyr Val Thr Thr Asp Tyr Asn Phe Lys Leu Pro 
            660                 665                 670         


Gly Ala Ser Glu Lys Ile Gly Ala Arg Glu Pro Glu Glu Ala His Lys 
        675                 680                 685             


Glu Lys Pro Tyr Arg Arg Pro Lys Phe Cys Arg Lys Met Lys 
    690                 695                 700         


<210>  9
<211>  1025
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Ser Ala Ala Lys Glu Asn Pro Cys Arg Lys Phe Gln Ala Asn Ile 
1               5                   10                  15      


Phe Asn Lys Ser Lys Cys Gln Asn Cys Phe Lys Pro Arg Glu Ser His 
            20                  25                  30          


Leu Leu Asn Asp Glu Asp Leu Thr Gln Ala Lys Pro Ile Tyr Gly Gly 
        35                  40                  45              


Trp Leu Leu Leu Ala Pro Asp Gly Thr Asp Phe Asp Asn Pro Val His 
    50                  55                  60                  


Arg Ser Arg Lys Trp Gln Arg Arg Phe Phe Ile Leu Tyr Glu His Gly 
65                  70                  75                  80  


Leu Leu Arg Tyr Ala Leu Asp Glu Met Pro Thr Thr Leu Pro Gln Gly 
                85                  90                  95      


Thr Ile Asn Met Asn Gln Cys Thr Asp Val Val Asp Gly Glu Gly Arg 
            100                 105                 110         


Thr Gly Gln Lys Phe Ser Leu Cys Ile Leu Thr Pro Glu Lys Glu His 
        115                 120                 125             


Phe Ile Arg Ala Glu Thr Lys Glu Ile Val Ser Gly Trp Leu Glu Met 
    130                 135                 140                 


Leu Met Val Tyr Pro Arg Thr Asn Lys Gln Asn Gln Lys Lys Lys Arg 
145                 150                 155                 160 


Lys Val Glu Pro Pro Thr Pro Gln Glu Pro Gly Pro Ala Lys Val Ala 
                165                 170                 175     


Val Thr Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ile Pro Ser 
            180                 185                 190         


Ala Glu Lys Val Pro Thr Thr Lys Ser Thr Leu Trp Gln Glu Glu Met 
        195                 200                 205             


Arg Thr Lys Asp Gln Pro Asp Gly Ser Ser Leu Ser Pro Ala Gln Ser 
    210                 215                 220                 


Pro Ser Gln Ser Gln Pro Pro Ala Ala Ser Ser Leu Arg Glu Pro Gly 
225                 230                 235                 240 


Leu Glu Ser Lys Glu Glu Glu Ser Ala Met Ser Ser Asp Arg Met Asp 
                245                 250                 255     


Cys Gly Arg Lys Val Arg Val Glu Ser Gly Tyr Phe Ser Leu Glu Lys 
            260                 265                 270         


Thr Lys Gln Asp Leu Lys Ala Glu Glu Gln Gln Leu Pro Pro Pro Leu 
        275                 280                 285             


Ser Pro Pro Ser Pro Ser Thr Pro Asn His Arg Arg Ser Gln Val Ile 
    290                 295                 300                 


Glu Lys Phe Glu Ala Leu Asp Ile Glu Lys Ala Glu His Met Glu Thr 
305                 310                 315                 320 


Asn Ala Val Gly Pro Ser Pro Ser Ser Asp Thr Arg Gln Gly Arg Ser 
                325                 330                 335     


Glu Lys Arg Ala Phe Pro Arg Lys Arg Asp Phe Thr Asn Glu Ala Pro 
            340                 345                 350         


Pro Ala Pro Leu Pro Asp Ala Ser Ala Ser Pro Leu Ser Pro His Arg 
        355                 360                 365             


Arg Ala Lys Ser Leu Asp Arg Arg Ser Thr Glu Pro Ser Val Thr Pro 
    370                 375                 380                 


Asp Leu Leu Asn Phe Lys Lys Gly Trp Leu Thr Lys Gln Tyr Glu Asp 
385                 390                 395                 400 


Gly Gln Trp Lys Lys His Trp Phe Val Leu Ala Asp Gln Ser Leu Arg 
                405                 410                 415     


Tyr Tyr Arg Asp Ser Val Ala Glu Glu Ala Ala Asp Leu Asp Gly Glu 
            420                 425                 430         


Ile Asp Leu Ser Ala Cys Tyr Asp Val Thr Glu Tyr Pro Val Gln Arg 
        435                 440                 445             


Asn Tyr Gly Phe Gln Ile His Thr Lys Glu Gly Glu Phe Thr Leu Ser 
    450                 455                 460                 


Ala Met Thr Ser Gly Ile Arg Arg Asn Trp Ile Gln Thr Ile Met Lys 
465                 470                 475                 480 


His Val His Pro Thr Thr Ala Pro Asp Val Thr Ser Ser Leu Pro Glu 
                485                 490                 495     


Glu Lys Asn Lys Ser Ser Cys Ser Phe Glu Thr Cys Pro Arg Pro Thr 
            500                 505                 510         


Glu Lys Gln Glu Ala Glu Leu Gly Glu Pro Asp Pro Glu Gln Lys Arg 
        515                 520                 525             


Ser Arg Ala Arg Glu Arg Arg Arg Glu Gly Arg Ser Lys Thr Phe Asp 
    530                 535                 540                 


Trp Ala Glu Phe Arg Pro Ile Gln Gln Ala Leu Ala Gln Glu Arg Val 
545                 550                 555                 560 


Gly Gly Val Gly Pro Ala Asp Thr His Glu Pro Leu Arg Pro Glu Ala 
                565                 570                 575     


Glu Pro Gly Glu Leu Glu Arg Glu Arg Ala Arg Arg Arg Glu Glu Arg 
            580                 585                 590         


Arg Lys Arg Phe Gly Met Leu Asp Ala Thr Asp Gly Pro Gly Thr Glu 
        595                 600                 605             


Asp Ala Ala Leu Arg Met Glu Val Asp Arg Ser Pro Gly Leu Pro Met 
    610                 615                 620                 


Ser Asp Leu Lys Thr His Asn Val His Val Glu Ile Glu Gln Arg Trp 
625                 630                 635                 640 


His Gln Val Glu Thr Thr Pro Leu Arg Glu Glu Lys Gln Val Pro Ile 
                645                 650                 655     


Ala Pro Val His Leu Ser Ser Glu Asp Gly Gly Asp Arg Leu Ser Thr 
            660                 665                 670         


His Glu Leu Thr Ser Leu Leu Glu Lys Glu Leu Glu Gln Ser Gln Lys 
        675                 680                 685             


Glu Ala Ser Asp Leu Leu Glu Gln Asn Arg Leu Leu Gln Asp Gln Leu 
    690                 695                 700                 


Arg Val Ala Leu Gly Arg Glu Gln Ser Ala Arg Glu Gly Tyr Val Leu 
705                 710                 715                 720 


Gln Ala Thr Cys Glu Arg Gly Phe Ala Ala Met Glu Glu Thr His Gln 
                725                 730                 735     


Lys Lys Ile Glu Asp Leu Gln Arg Gln His Gln Arg Glu Leu Glu Lys 
            740                 745                 750         


Leu Arg Glu Glu Lys Asp Arg Leu Leu Ala Glu Glu Thr Ala Ala Thr 
        755                 760                 765             


Ile Ser Ala Ile Glu Ala Met Lys Asn Ala His Arg Glu Glu Met Glu 
    770                 775                 780                 


Arg Glu Leu Glu Lys Ser Gln Arg Ser Gln Ile Ser Ser Val Asn Ser 
785                 790                 795                 800 


Asp Val Glu Ala Leu Arg Arg Gln Tyr Leu Glu Glu Leu Gln Ser Val 
                805                 810                 815     


Gln Arg Glu Leu Glu Val Leu Ser Glu Gln Tyr Ser Gln Lys Cys Leu 
            820                 825                 830         


Glu Asn Ala His Leu Ala Gln Ala Leu Glu Ala Glu Arg Gln Ala Leu 
        835                 840                 845             


Arg Gln Cys Gln Arg Glu Asn Gln Glu Leu Asn Ala His Asn Gln Glu 
    850                 855                 860                 


Leu Asn Asn Arg Leu Ala Ala Glu Ile Thr Arg Leu Arg Thr Leu Leu 
865                 870                 875                 880 


Thr Gly Asp Gly Gly Gly Glu Ala Thr Gly Ser Pro Leu Ala Gln Gly 
                885                 890                 895     


Lys Asp Ala Tyr Glu Leu Glu Val Leu Leu Arg Val Lys Glu Ser Glu 
            900                 905                 910         


Ile Gln Tyr Leu Lys Gln Glu Ile Ser Ser Leu Lys Asp Glu Leu Gln 
        915                 920                 925             


Thr Ala Leu Arg Asp Lys Lys Tyr Ala Ser Asp Lys Tyr Lys Asp Ile 
    930                 935                 940                 


Tyr Thr Glu Leu Ser Ile Ala Lys Ala Lys Ala Asp Cys Asp Ile Ser 
945                 950                 955                 960 


Arg Leu Lys Glu Gln Leu Lys Ala Ala Thr Glu Ala Leu Gly Glu Lys 
                965                 970                 975     


Ser Pro Asp Ser Ala Thr Val Ser Gly Tyr Asp Ile Met Lys Ser Lys 
            980                 985                 990         


Ser Asn Pro Asp Phe Leu Lys Lys  Asp Arg Ser Cys Val  Thr Arg Gln 
        995                 1000                 1005             


Leu Arg  Asn Ile Arg Ser Lys  Ser Val Ile Glu Gln  Val Ser Trp 
    1010                 1015                 1020             


Asp Thr  
    1025 


<210>  10
<211>  406
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ser Ala Leu Gly Ala Val Ile Ala Leu Leu Leu Trp Gly Gln Leu 
1               5                   10                  15      


Phe Ala Val Asp Ser Gly Asn Asp Val Thr Asp Ile Ala Asp Asp Gly 
            20                  25                  30          


Cys Pro Lys Pro Pro Glu Ile Ala His Gly Tyr Val Glu His Ser Val 
        35                  40                  45              


Arg Tyr Gln Cys Lys Asn Tyr Tyr Lys Leu Arg Thr Glu Gly Asp Gly 
    50                  55                  60                  


Val Tyr Thr Leu Asn Asp Lys Lys Gln Trp Ile Asn Lys Ala Val Gly 
65                  70                  75                  80  


Asp Lys Leu Pro Glu Cys Glu Ala Asp Asp Gly Cys Pro Lys Pro Pro 
                85                  90                  95      


Glu Ile Ala His Gly Tyr Val Glu His Ser Val Arg Tyr Gln Cys Lys 
            100                 105                 110         


Asn Tyr Tyr Lys Leu Arg Thr Glu Gly Asp Gly Val Tyr Thr Leu Asn 
        115                 120                 125             


Asn Glu Lys Gln Trp Ile Asn Lys Ala Val Gly Asp Lys Leu Pro Glu 
    130                 135                 140                 


Cys Glu Ala Val Cys Gly Lys Pro Lys Asn Pro Ala Asn Pro Val Gln 
145                 150                 155                 160 


Arg Ile Leu Gly Gly His Leu Asp Ala Lys Gly Ser Phe Pro Trp Gln 
                165                 170                 175     


Ala Lys Met Val Ser His His Asn Leu Thr Thr Gly Ala Thr Leu Ile 
            180                 185                 190         


Asn Glu Gln Trp Leu Leu Thr Thr Ala Lys Asn Leu Phe Leu Asn His 
        195                 200                 205             


Ser Glu Asn Ala Thr Ala Lys Asp Ile Ala Pro Thr Leu Thr Leu Tyr 
    210                 215                 220                 


Val Gly Lys Lys Gln Leu Val Glu Ile Glu Lys Val Val Leu His Pro 
225                 230                 235                 240 


Asn Tyr Ser Gln Val Asp Ile Gly Leu Ile Lys Leu Lys Gln Lys Val 
                245                 250                 255     


Ser Val Asn Glu Arg Val Met Pro Ile Cys Leu Pro Ser Lys Asp Tyr 
            260                 265                 270         


Ala Glu Val Gly Arg Val Gly Tyr Val Ser Gly Trp Gly Arg Asn Ala 
        275                 280                 285             


Asn Phe Lys Phe Thr Asp His Leu Lys Tyr Val Met Leu Pro Val Ala 
    290                 295                 300                 


Asp Gln Asp Gln Cys Ile Arg His Tyr Glu Gly Ser Thr Val Pro Glu 
305                 310                 315                 320 


Lys Lys Thr Pro Lys Ser Pro Val Gly Val Gln Pro Ile Leu Asn Glu 
                325                 330                 335     


His Thr Phe Cys Ala Gly Met Ser Lys Tyr Gln Glu Asp Thr Cys Tyr 
            340                 345                 350         


Gly Asp Ala Gly Ser Ala Phe Ala Val His Asp Leu Glu Glu Asp Thr 
        355                 360                 365             


Trp Tyr Ala Thr Gly Ile Leu Ser Phe Asp Lys Ser Cys Ala Val Ala 
    370                 375                 380                 


Glu Tyr Gly Val Tyr Val Lys Val Thr Ser Ile Gln Asp Trp Val Gln 
385                 390                 395                 400 


Lys Thr Ile Ala Glu Asn 
                405     


<210>  11
<211>  318
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ala Ala Gln Gly Cys Ala Ala Ser Arg Leu Leu Gln Leu Leu Leu 
1               5                   10                  15      


Gln Leu Leu Leu Leu Leu Leu Leu Leu Ala Ala Gly Gly Ala Arg Ala 
            20                  25                  30          


Arg Trp Arg Gly Glu Gly Thr Ser Ala His Leu Arg Asp Ile Phe Leu 
        35                  40                  45              


Gly Arg Cys Ala Glu Tyr Arg Ala Leu Leu Ser Pro Glu Gln Arg Asn 
    50                  55                  60                  


Lys Asn Cys Thr Ala Ile Trp Glu Ala Phe Lys Val Ala Leu Asp Lys 
65                  70                  75                  80  


Asp Pro Cys Ser Val Leu Pro Ser Asp Tyr Asp Leu Phe Ile Asn Leu 
                85                  90                  95      


Ser Arg His Ser Ile Pro Arg Asp Lys Ser Leu Phe Trp Glu Asn Ser 
            100                 105                 110         


His Leu Leu Val Asn Ser Phe Ala Asp Asn Thr Arg Arg Phe Met Pro 
        115                 120                 125             


Leu Ser Asp Val Leu Tyr Gly Arg Val Ala Asp Phe Leu Ser Trp Cys 
    130                 135                 140                 


Arg Gln Lys Asn Asp Ser Gly Leu Asp Tyr Gln Ser Cys Pro Thr Ser 
145                 150                 155                 160 


Glu Asp Cys Glu Asn Asn Pro Val Asp Ser Phe Trp Lys Arg Ala Ser 
                165                 170                 175     


Ile Gln Tyr Ser Lys Asp Ser Ser Gly Val Ile His Val Met Leu Asn 
            180                 185                 190         


Gly Ser Glu Pro Thr Gly Ala Tyr Pro Ile Lys Gly Phe Phe Ala Asp 
        195                 200                 205             


Tyr Glu Ile Pro Asn Leu Gln Lys Glu Lys Ile Thr Arg Ile Glu Ile 
    210                 215                 220                 


Trp Val Met His Glu Ile Gly Gly Pro Asn Val Glu Ser Cys Gly Glu 
225                 230                 235                 240 


Gly Ser Met Lys Val Leu Glu Lys Arg Leu Lys Asp Met Gly Phe Gln 
                245                 250                 255     


Tyr Ser Cys Ile Asn Asp Tyr Arg Pro Val Lys Leu Leu Gln Cys Val 
            260                 265                 270         


Asp His Ser Thr His Pro Asp Cys Ala Leu Lys Ser Ala Ala Ala Ala 
        275                 280                 285             


Thr Gln Arg Lys Ala Pro Ser Leu Tyr Thr Glu Gln Arg Ala Gly Leu 
    290                 295                 300                 


Ile Ile Pro Leu Phe Leu Val Leu Ala Ser Arg Thr Gln Leu 
305                 310                 315             


<210>  12
<211>  663
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ser Ala Arg Leu Pro Val Leu Ser Pro Pro Arg Trp Pro Arg Leu 
1               5                   10                  15      


Leu Leu Leu Ser Leu Leu Leu Leu Gly Ala Val Pro Gly Pro Arg Arg 
            20                  25                  30          


Ser Gly Ala Phe Tyr Leu Pro Gly Leu Ala Pro Val Asn Phe Cys Asp 
        35                  40                  45              


Glu Glu Lys Lys Ser Asp Glu Cys Lys Ala Glu Ile Glu Leu Phe Val 
    50                  55                  60                  


Asn Arg Leu Asp Ser Val Glu Ser Val Leu Pro Tyr Glu Tyr Thr Ala 
65                  70                  75                  80  


Phe Asp Phe Cys Gln Ala Ser Glu Gly Lys Arg Pro Ser Glu Asn Leu 
                85                  90                  95      


Gly Gln Val Leu Phe Gly Glu Arg Ile Glu Pro Ser Pro Tyr Lys Phe 
            100                 105                 110         


Thr Phe Asn Lys Lys Glu Thr Cys Lys Leu Val Cys Thr Lys Thr Tyr 
        115                 120                 125             


His Thr Glu Lys Ala Glu Asp Lys Gln Lys Leu Glu Phe Leu Lys Lys 
    130                 135                 140                 


Ser Met Leu Leu Asn Tyr Gln His His Trp Ile Val Asp Asn Met Pro 
145                 150                 155                 160 


Val Thr Trp Cys Tyr Asp Val Glu Asp Gly Gln Arg Phe Cys Asn Pro 
                165                 170                 175     


Gly Phe Pro Ile Gly Cys Tyr Ile Thr Asp Lys Gly His Ala Lys Asp 
            180                 185                 190         


Ala Cys Val Ile Ser Ser Asp Phe His Glu Arg Asp Thr Phe Tyr Ile 
        195                 200                 205             


Phe Asn His Val Asp Ile Lys Ile Tyr Tyr His Val Val Glu Thr Gly 
    210                 215                 220                 


Ser Met Gly Ala Arg Leu Val Ala Ala Lys Leu Glu Pro Lys Ser Phe 
225                 230                 235                 240 


Lys His Thr His Ile Asp Lys Pro Asp Cys Ser Gly Pro Pro Met Asp 
                245                 250                 255     


Ile Ser Asn Lys Ala Ser Gly Glu Ile Lys Ile Ala Tyr Thr Tyr Ser 
            260                 265                 270         


Val Ser Phe Glu Glu Asp Asp Lys Ile Arg Trp Ala Ser Arg Trp Asp 
        275                 280                 285             


Tyr Ile Leu Glu Ser Met Pro His Thr His Ile Gln Trp Phe Ser Ile 
    290                 295                 300                 


Met Asn Ser Leu Val Ile Val Leu Phe Leu Ser Gly Met Val Ala Met 
305                 310                 315                 320 


Ile Met Leu Arg Thr Leu His Lys Asp Ile Ala Arg Tyr Asn Gln Met 
                325                 330                 335     


Asp Ser Thr Glu Asp Ala Gln Glu Glu Phe Gly Trp Lys Leu Val His 
            340                 345                 350         


Gly Asp Ile Phe Arg Pro Pro Arg Lys Gly Met Leu Leu Ser Val Phe 
        355                 360                 365             


Leu Gly Ser Gly Thr Gln Ile Leu Ile Met Thr Phe Val Thr Leu Phe 
    370                 375                 380                 


Phe Ala Cys Leu Gly Phe Leu Ser Pro Ala Asn Arg Gly Ala Leu Met 
385                 390                 395                 400 


Thr Cys Ala Val Val Leu Trp Val Leu Leu Gly Thr Pro Ala Gly Tyr 
                405                 410                 415     


Val Ala Ala Arg Phe Tyr Lys Ser Phe Gly Gly Glu Lys Trp Lys Thr 
            420                 425                 430         


Asn Val Leu Leu Thr Ser Phe Leu Cys Pro Gly Ile Val Phe Ala Asp 
        435                 440                 445             


Phe Phe Ile Met Asn Leu Ile Leu Trp Gly Glu Gly Ser Ser Ala Ala 
    450                 455                 460                 


Ile Pro Phe Gly Thr Leu Val Ala Ile Leu Ala Leu Trp Phe Cys Ile 
465                 470                 475                 480 


Ser Val Pro Leu Thr Phe Ile Gly Ala Tyr Phe Gly Phe Lys Lys Asn 
                485                 490                 495     


Ala Ile Glu His Pro Val Arg Thr Asn Gln Ile Pro Arg Gln Ile Pro 
            500                 505                 510         


Glu Gln Ser Phe Tyr Thr Lys Pro Leu Pro Gly Ile Ile Met Gly Gly 
        515                 520                 525             


Ile Leu Pro Phe Gly Cys Ile Phe Ile Gln Leu Phe Phe Ile Leu Asn 
    530                 535                 540                 


Ser Ile Trp Ser His Gln Met Tyr Tyr Met Phe Gly Phe Leu Phe Leu 
545                 550                 555                 560 


Val Phe Ile Ile Leu Val Ile Thr Cys Ser Glu Ala Thr Ile Leu Leu 
                565                 570                 575     


Cys Tyr Phe His Leu Cys Ala Glu Asp Tyr His Trp Gln Trp Arg Ser 
            580                 585                 590         


Phe Leu Thr Ser Gly Phe Thr Ala Val Tyr Phe Leu Ile Tyr Ala Val 
        595                 600                 605             


His Tyr Phe Phe Ser Lys Leu Gln Ile Thr Gly Thr Ala Ser Thr Ile 
    610                 615                 620                 


Leu Tyr Phe Gly Tyr Thr Met Ile Met Val Leu Ile Phe Phe Leu Phe 
625                 630                 635                 640 


Thr Gly Thr Ile Gly Phe Phe Ala Cys Phe Trp Phe Val Thr Lys Ile 
                645                 650                 655     


Tyr Ser Val Val Lys Val Asp 
            660             


<210>  13
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Ser Thr Ala Arg Glu Gln Pro Ile Phe Ser Thr Arg Ala His Val 
1               5                   10                  15      


Phe Gln Ile Asp Pro Ala Thr Lys Arg Asn Trp Ile Pro Ala Gly Lys 
            20                  25                  30          


His Ala Leu Thr Val Ser Tyr Phe Tyr Asp Ala Thr Arg Asn Val Tyr 
        35                  40                  45              


Arg Ile Ile Ser Ile Gly Gly Ala Lys Ala Ile Ile Asn Ser Thr Val 
    50                  55                  60                  


Thr Pro Asn Met Thr Phe Thr Lys Thr Ser Gln Lys Phe Gly Gln Trp 
65                  70                  75                  80  


Ala Asp Ser Arg Ala Asn Thr Val Tyr Gly Leu Gly Phe Ala Ser Glu 
                85                  90                  95      


Gln His Leu Thr Gln Phe Ala Glu Lys Phe Gln Glu Val Lys Glu Ala 
            100                 105                 110         


Ala Arg Leu Ala Arg Glu Lys Ser Gln Asp Gly Gly Glu Leu Thr Ser 
        115                 120                 125             


Pro Ala Leu Gly Leu Ala Ser His Gln Val Pro Pro Ser Pro Leu Val 
    130                 135                 140                 


Ser Ala Asn Gly Pro Gly Glu Glu Lys Leu Phe Arg Ser Gln Ser Ala 
145                 150                 155                 160 


Asp Ala Pro Gly Pro Thr Glu Arg Glu Arg Leu Lys Lys Met Leu Ser 
                165                 170                 175     


Glu Gly Ser Val Gly Glu Val Gln Trp Glu Ala Glu Phe Phe Ala Leu 
            180                 185                 190         


Gln Asp Ser Asn Asn Lys Leu Ala Gly Ala Leu Arg Glu Ala Asn Ala 
        195                 200                 205             


Ala Ala Ala Gln Trp Arg Gln Gln Leu Glu Ala Gln Arg Ala Glu Ala 
    210                 215                 220                 


Glu Arg Leu Arg Gln Arg Val Ala Glu Leu Glu Ala Gln Ala Ala Ser 
225                 230                 235                 240 


Glu Val Thr Pro Thr Gly Glu Lys Glu Gly Leu Gly Gln Gly Gln Ser 
                245                 250                 255     


Leu Glu Gln Leu Glu Ala Leu Val Gln Thr Lys Asp Gln Glu Ile Gln 
            260                 265                 270         


Thr Leu Lys Ser Gln Thr Gly Gly Pro Arg Glu Ala Leu Glu Ala Ala 
        275                 280                 285             


Glu Arg Glu Glu Thr Gln Gln Lys Val Gln Asp Leu Glu Thr Arg Asn 
    290                 295                 300                 


Ala Glu Leu Glu His Gln Leu Arg Ala Met Glu Arg Ser Leu Glu Glu 
305                 310                 315                 320 


Ala Arg Ala Glu Arg Glu Arg Ala Arg Ala Glu Val Gly Arg Ala Ala 
                325                 330                 335     


Gln Leu Leu Asp Val Ser Leu Phe Glu Leu Ser Glu Leu Arg Glu Gly 
            340                 345                 350         


Leu Ala Arg Leu Ala Glu Ala Ala Pro 
        355                 360     


<210>  15
<211>  469
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Ser Ile Phe Pro Lys Ile Ser Leu Arg Pro Glu Val Glu Asn Tyr 
1               5                   10                  15      


Leu Lys Glu Gly Phe Met Asn Lys Glu Ile Val Thr Ala Leu Gly Lys 
            20                  25                  30          


Gln Glu Ala Glu Arg Lys Phe Glu Thr Leu Leu Lys His Leu Ser His 
        35                  40                  45              


Pro Pro Ser Phe Thr Thr Val Arg Val Asn Thr His Leu Ala Ser Val 
    50                  55                  60                  


Gln His Val Lys Asn Leu Leu Leu Asp Glu Leu Gln Lys Gln Phe Asn 
65                  70                  75                  80  


Gly Leu Ser Val Pro Ile Leu Gln His Pro Asp Leu Gln Asp Val Leu 
                85                  90                  95      


Leu Ile Pro Val Ile Gly Pro Arg Lys Asn Ile Lys Lys Gln Gln Cys 
            100                 105                 110         


Glu Ala Ile Val Gly Ala Gln Cys Gly Asn Ala Val Leu Arg Gly Ala 
        115                 120                 125             


His Val Tyr Ala Pro Gly Ile Val Ser Ala Ser Gln Phe Met Lys Ala 
    130                 135                 140                 


Gly Asp Val Ile Ser Val Tyr Ser Asp Ile Lys Gly Lys Cys Lys Lys 
145                 150                 155                 160 


Gly Ala Lys Glu Phe Asp Gly Thr Lys Val Phe Leu Gly Asn Gly Ile 
                165                 170                 175     


Ser Glu Leu Ser Arg Lys Glu Ile Phe Ser Gly Leu Pro Glu Leu Lys 
            180                 185                 190         


Gly Met Gly Ile Arg Met Thr Glu Pro Val Tyr Leu Ser Pro Ser Phe 
        195                 200                 205             


Asp Ser Val Leu Pro Arg Tyr Leu Phe Leu Gln Asn Leu Pro Ser Ala 
    210                 215                 220                 


Leu Val Ser His Val Leu Asn Pro Gln Pro Gly Glu Lys Ile Leu Asp 
225                 230                 235                 240 


Leu Cys Ala Ala Pro Gly Gly Lys Thr Thr His Ile Ala Ala Leu Met 
                245                 250                 255     


His Asp Gln Gly Glu Val Ile Ala Leu Asp Lys Ile Phe Asn Lys Val 
            260                 265                 270         


Glu Lys Ile Lys Gln Asn Ala Leu Leu Leu Gly Leu Asn Ser Ile Arg 
        275                 280                 285             


Ala Phe Cys Phe Asp Gly Thr Lys Ala Val Lys Leu Asp Met Val Glu 
    290                 295                 300                 


Asp Thr Glu Gly Glu Pro Pro Phe Leu Pro Glu Ser Phe Asp Arg Ile 
305                 310                 315                 320 


Leu Leu Asp Ala Pro Cys Ser Gly Met Gly Gln Arg Pro Asn Met Ala 
                325                 330                 335     


Cys Thr Trp Ser Val Lys Glu Val Ala Ser Tyr Gln Pro Leu Gln Arg 
            340                 345                 350         


Lys Leu Phe Thr Ala Ala Val Gln Leu Leu Lys Pro Glu Gly Val Leu 
        355                 360                 365             


Val Tyr Ser Thr Cys Thr Ile Thr Leu Ala Glu Asn Glu Glu Gln Val 
    370                 375                 380                 


Ala Trp Ala Leu Thr Lys Phe Pro Cys Leu Gln Leu Gln Pro Gln Glu 
385                 390                 395                 400 


Pro Gln Ile Gly Gly Glu Gly Met Arg Gly Ala Gly Leu Ser Cys Glu 
                405                 410                 415     


Gln Leu Lys Gln Leu Gln Arg Phe Asp Pro Ser Ala Val Pro Leu Pro 
            420                 425                 430         


Asp Thr Asp Met Asp Ser Leu Arg Glu Ala Arg Arg Glu Asp Met Leu 
        435                 440                 445             


Arg Leu Ala Asn Lys Asp Ser Ile Gly Phe Phe Ile Ala Lys Phe Val 
    450                 455                 460                 


Lys Cys Lys Ser Thr 
465                 


<210>  16
<211>  986
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Ala Gly Ile Phe Tyr Phe Ala Leu Phe Ser Cys Leu Phe Gly Ile 
1               5                   10                  15      


Cys Asp Ala Val Thr Gly Ser Arg Val Tyr Pro Ala Asn Glu Val Thr 
            20                  25                  30          


Leu Leu Asp Ser Arg Ser Val Gln Gly Glu Leu Gly Trp Ile Ala Ser 
        35                  40                  45              


Pro Leu Glu Gly Gly Trp Glu Glu Val Ser Ile Met Asp Glu Lys Asn 
    50                  55                  60                  


Thr Pro Ile Arg Thr Tyr Gln Val Cys Asn Val Met Glu Pro Ser Gln 
65                  70                  75                  80  


Asn Asn Trp Leu Arg Thr Asp Trp Ile Thr Arg Glu Gly Ala Gln Arg 
                85                  90                  95      


Val Tyr Ile Glu Ile Lys Phe Thr Leu Arg Asp Cys Asn Ser Leu Pro 
            100                 105                 110         


Gly Val Met Gly Thr Cys Lys Glu Thr Phe Asn Leu Tyr Tyr Tyr Glu 
        115                 120                 125             


Ser Asp Asn Asp Lys Glu Arg Phe Ile Arg Glu Asn Gln Phe Val Lys 
    130                 135                 140                 


Ile Asp Thr Ile Ala Ala Asp Glu Ser Phe Thr Gln Val Asp Ile Gly 
145                 150                 155                 160 


Asp Arg Ile Met Lys Leu Asn Thr Glu Ile Arg Asp Val Gly Pro Leu 
                165                 170                 175     


Ser Lys Lys Gly Phe Tyr Leu Ala Phe Gln Asp Val Gly Ala Cys Ile 
            180                 185                 190         


Ala Leu Val Ser Val Arg Val Phe Tyr Lys Lys Cys Pro Leu Thr Val 
        195                 200                 205             


Arg Asn Leu Ala Gln Phe Pro Asp Thr Ile Thr Gly Ala Asp Thr Ser 
    210                 215                 220                 


Ser Leu Val Glu Val Arg Gly Ser Cys Val Asn Asn Ser Glu Glu Lys 
225                 230                 235                 240 


Asp Val Pro Lys Met Tyr Cys Gly Ala Asp Gly Glu Trp Leu Val Pro 
                245                 250                 255     


Ile Gly Asn Cys Leu Cys Asn Ala Gly His Glu Glu Arg Ser Gly Glu 
            260                 265                 270         


Cys Gln Ala Cys Lys Ile Gly Tyr Tyr Lys Ala Leu Ser Thr Asp Ala 
        275                 280                 285             


Thr Cys Ala Lys Cys Pro Pro His Ser Tyr Ser Val Trp Glu Gly Ala 
    290                 295                 300                 


Thr Ser Cys Thr Cys Asp Arg Gly Phe Phe Arg Ala Asp Asn Asp Ala 
305                 310                 315                 320 


Ala Ser Met Pro Cys Thr Arg Pro Pro Ser Ala Pro Leu Asn Leu Ile 
                325                 330                 335     


Ser Asn Val Asn Glu Thr Ser Val Asn Leu Glu Trp Ser Ser Pro Gln 
            340                 345                 350         


Asn Thr Gly Gly Arg Gln Asp Ile Ser Tyr Asn Val Val Cys Lys Lys 
        355                 360                 365             


Cys Gly Ala Gly Asp Pro Ser Lys Cys Arg Pro Cys Gly Ser Gly Val 
    370                 375                 380                 


His Tyr Thr Pro Gln Gln Asn Gly Leu Lys Thr Thr Lys Val Ser Ile 
385                 390                 395                 400 


Thr Asp Leu Leu Ala His Thr Asn Tyr Thr Phe Glu Ile Trp Ala Val 
                405                 410                 415     


Asn Gly Val Ser Lys Tyr Asn Pro Asn Pro Asp Gln Ser Val Ser Val 
            420                 425                 430         


Thr Val Thr Thr Asn Gln Ala Ala Pro Ser Ser Ile Ala Leu Val Gln 
        435                 440                 445             


Ala Lys Glu Val Thr Arg Tyr Ser Val Ala Leu Ala Trp Leu Glu Pro 
    450                 455                 460                 


Asp Arg Pro Asn Gly Val Ile Leu Glu Tyr Glu Val Lys Tyr Tyr Glu 
465                 470                 475                 480 


Lys Asp Gln Asn Glu Arg Ser Tyr Arg Ile Val Arg Thr Ala Ala Arg 
                485                 490                 495     


Asn Thr Asp Ile Lys Gly Leu Asn Pro Leu Thr Ser Tyr Val Phe His 
            500                 505                 510         


Val Arg Ala Arg Thr Ala Ala Gly Tyr Gly Asp Phe Ser Glu Pro Leu 
        515                 520                 525             


Glu Val Thr Thr Asn Thr Val Pro Ser Arg Ile Ile Gly Asp Gly Ala 
    530                 535                 540                 


Asn Ser Thr Val Leu Leu Val Ser Val Ser Gly Ser Val Val Leu Val 
545                 550                 555                 560 


Val Ile Leu Ile Ala Ala Phe Val Ile Ser Arg Arg Arg Ser Lys Tyr 
                565                 570                 575     


Ser Lys Ala Lys Gln Glu Ala Asp Glu Glu Lys His Leu Asn Gln Gly 
            580                 585                 590         


Val Arg Thr Tyr Val Asp Pro Phe Thr Tyr Glu Asp Pro Asn Gln Ala 
        595                 600                 605             


Val Arg Glu Phe Ala Lys Glu Ile Asp Ala Ser Cys Ile Lys Ile Glu 
    610                 615                 620                 


Lys Val Ile Gly Val Gly Glu Phe Gly Glu Val Cys Ser Gly Arg Leu 
625                 630                 635                 640 


Lys Val Pro Gly Lys Arg Glu Ile Cys Val Ala Ile Lys Thr Leu Lys 
                645                 650                 655     


Ala Gly Tyr Thr Asp Lys Gln Arg Arg Asp Phe Leu Ser Glu Ala Ser 
            660                 665                 670         


Ile Met Gly Gln Phe Asp His Pro Asn Ile Ile His Leu Glu Gly Val 
        675                 680                 685             


Val Thr Lys Cys Lys Pro Val Met Ile Ile Thr Glu Tyr Met Glu Asn 
    690                 695                 700                 


Gly Ser Leu Asp Ala Phe Leu Arg Lys Asn Asp Gly Arg Phe Thr Val 
705                 710                 715                 720 


Ile Gln Leu Val Gly Met Leu Arg Gly Ile Gly Ser Gly Met Lys Tyr 
                725                 730                 735     


Leu Ser Asp Met Ser Tyr Val His Arg Asp Leu Ala Ala Arg Asn Ile 
            740                 745                 750         


Leu Val Asn Ser Asn Leu Val Cys Lys Val Ser Asp Phe Gly Met Ser 
        755                 760                 765             


Arg Val Leu Glu Asp Asp Pro Glu Ala Ala Tyr Thr Thr Arg Gly Gly 
    770                 775                 780                 


Lys Ile Pro Ile Arg Trp Thr Ala Pro Glu Ala Ile Ala Tyr Arg Lys 
785                 790                 795                 800 


Phe Thr Ser Ala Ser Asp Val Trp Ser Tyr Gly Ile Val Met Trp Glu 
                805                 810                 815     


Val Met Ser Tyr Gly Glu Arg Pro Tyr Trp Asp Met Ser Asn Gln Asp 
            820                 825                 830         


Val Ile Lys Ala Ile Glu Glu Gly Tyr Arg Leu Pro Pro Pro Met Asp 
        835                 840                 845             


Cys Pro Ile Ala Leu His Gln Leu Met Leu Asp Cys Trp Gln Lys Glu 
    850                 855                 860                 


Arg Ser Asp Arg Pro Lys Phe Gly Gln Ile Val Asn Met Leu Asp Lys 
865                 870                 875                 880 


Leu Ile Arg Asn Pro Asn Ser Leu Lys Arg Thr Gly Thr Glu Ser Ser 
                885                 890                 895     


Arg Pro Asn Thr Ala Leu Leu Asp Pro Ser Ser Pro Glu Phe Ser Ala 
            900                 905                 910         


Val Val Ser Val Gly Asp Trp Leu Gln Ala Ile Lys Met Asp Arg Tyr 
        915                 920                 925             


Lys Asp Asn Phe Thr Ala Ala Gly Tyr Thr Thr Leu Glu Ala Val Val 
    930                 935                 940                 


His Val Asn Gln Glu Asp Leu Ala Arg Ile Gly Ile Thr Ala Ile Thr 
945                 950                 955                 960 


His Gln Asn Lys Ile Leu Ser Ser Val Gln Ala Met Arg Thr Gln Met 
                965                 970                 975     


Gln Gln Met His Gly Arg Met Val Pro Val 
            980                 985     


<210>  17
<211>  1161
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Lys Lys Phe Ser Arg Met Pro Lys Ser Glu Gly Gly Ser Gly Gly 
1               5                   10                  15      


Gly Ala Ala Gly Gly Gly Ala Gly Gly Ala Gly Ala Gly Ala Gly Cys 
            20                  25                  30          


Gly Ser Gly Gly Ser Ser Val Gly Val Arg Val Phe Ala Val Gly Arg 
        35                  40                  45              


His Gln Val Thr Leu Glu Glu Ser Leu Ala Glu Gly Gly Phe Ser Thr 
    50                  55                  60                  


Val Phe Leu Val Arg Thr His Gly Gly Ile Arg Cys Ala Leu Lys Arg 
65                  70                  75                  80  


Met Tyr Val Asn Asn Met Pro Asp Leu Asn Val Cys Lys Arg Glu Ile 
                85                  90                  95      


Thr Ile Met Lys Glu Leu Ser Gly His Lys Asn Ile Val Gly Tyr Leu 
            100                 105                 110         


Asp Cys Ala Val Asn Ser Ile Ser Asp Asn Val Trp Glu Val Leu Ile 
        115                 120                 125             


Leu Met Glu Tyr Cys Arg Ala Gly Gln Val Val Asn Gln Met Asn Lys 
    130                 135                 140                 


Lys Leu Gln Thr Gly Phe Thr Glu Pro Glu Val Leu Gln Ile Phe Cys 
145                 150                 155                 160 


Asp Thr Cys Glu Ala Val Ala Arg Leu His Gln Cys Lys Thr Pro Ile 
                165                 170                 175     


Ile His Arg Asp Leu Lys Val Glu Asn Ile Leu Leu Asn Asp Gly Gly 
            180                 185                 190         


Asn Tyr Val Leu Cys Asp Phe Gly Ser Ala Thr Asn Lys Phe Leu Asn 
        195                 200                 205             


Pro Gln Lys Asp Gly Val Asn Val Val Glu Glu Glu Ile Lys Lys Tyr 
    210                 215                 220                 


Thr Thr Leu Ser Tyr Arg Ala Pro Glu Met Ile Asn Leu Tyr Gly Gly 
225                 230                 235                 240 


Lys Pro Ile Thr Thr Lys Ala Asp Ile Trp Ala Leu Gly Cys Leu Leu 
                245                 250                 255     


Tyr Lys Leu Cys Phe Phe Thr Leu Pro Phe Gly Glu Ser Gln Val Ala 
            260                 265                 270         


Ile Cys Asp Gly Asn Phe Thr Ile Pro Asp Asn Ser Arg Tyr Ser Arg 
        275                 280                 285             


Asn Ile His Cys Leu Ile Arg Phe Met Leu Glu Pro Asp Pro Glu His 
    290                 295                 300                 


Arg Pro Asp Ile Phe Gln Val Ser Tyr Phe Ala Phe Lys Phe Ala Lys 
305                 310                 315                 320 


Lys Asp Cys Pro Val Ser Asn Ile Asn Asn Ser Ser Ile Pro Ser Ala 
                325                 330                 335     


Leu Pro Glu Pro Met Thr Ala Ser Glu Ala Ala Ala Arg Lys Ser Gln 
            340                 345                 350         


Ile Lys Ala Arg Ile Thr Asp Thr Ile Gly Pro Thr Glu Thr Ser Ile 
        355                 360                 365             


Ala Pro Arg Gln Arg Pro Lys Ala Asn Ser Ala Thr Thr Ala Thr Pro 
    370                 375                 380                 


Ser Val Leu Thr Ile Gln Ser Ser Ala Thr Pro Val Lys Val Leu Ala 
385                 390                 395                 400 


Pro Gly Glu Phe Gly Asn His Arg Pro Lys Gly Ala Leu Arg Pro Gly 
                405                 410                 415     


Asn Gly Pro Glu Ile Leu Leu Gly Gln Gly Pro Pro Gln Gln Pro Pro 
            420                 425                 430         


Gln Gln His Arg Val Leu Gln Gln Leu Gln Gln Gly Asp Trp Arg Leu 
        435                 440                 445             


Gln Gln Leu His Leu Gln His Arg His Pro His Gln Gln Gln Gln Gln 
    450                 455                 460                 


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
465                 470                 475                 480 


Gln Gln Gln Gln Gln Gln His His His His His His His His Leu Leu 
                485                 490                 495     


Gln Asp Ala Tyr Met Gln Gln Tyr Gln His Ala Thr Gln Gln Gln Gln 
            500                 505                 510         


Met Leu Gln Gln Gln Phe Leu Met His Ser Val Tyr Gln Pro Gln Pro 
        515                 520                 525             


Ser Ala Ser Gln Tyr Pro Thr Met Met Pro Gln Tyr Gln Gln Ala Phe 
    530                 535                 540                 


Phe Gln Gln Gln Met Leu Ala Gln His Gln Pro Ser Gln Gln Gln Ala 
545                 550                 555                 560 


Ser Pro Glu Tyr Leu Thr Ser Pro Gln Glu Phe Ser Pro Ala Leu Val 
                565                 570                 575     


Ser Tyr Thr Ser Ser Leu Pro Ala Gln Val Gly Thr Ile Met Asp Ser 
            580                 585                 590         


Ser Tyr Ser Ala Asn Arg Ser Val Ala Asp Lys Glu Ala Ile Ala Asn 
        595                 600                 605             


Phe Thr Asn Gln Lys Asn Ile Ser Asn Pro Pro Asp Met Ser Gly Trp 
    610                 615                 620                 


Asn Pro Phe Gly Glu Asp Asn Phe Ser Lys Leu Thr Glu Glu Glu Leu 
625                 630                 635                 640 


Leu Asp Arg Glu Phe Asp Leu Leu Arg Ser Asn Arg Leu Glu Glu Arg 
                645                 650                 655     


Ala Ser Ser Asp Lys Asn Val Asp Ser Leu Ser Ala Pro His Asn His 
            660                 665                 670         


Pro Pro Glu Asp Pro Phe Gly Ser Val Pro Phe Ile Ser His Ser Gly 
        675                 680                 685             


Ser Pro Glu Lys Lys Ala Glu His Ser Ser Ile Asn Gln Glu Asn Gly 
    690                 695                 700                 


Thr Ala Asn Pro Ile Lys Asn Gly Lys Thr Ser Pro Ala Ser Lys Asp 
705                 710                 715                 720 


Gln Arg Thr Gly Lys Lys Thr Ser Val Gln Gly Gln Val Gln Lys Gly 
                725                 730                 735     


Asn Asp Glu Ser Glu Ser Asp Phe Glu Ser Asp Pro Pro Ser Pro Lys 
            740                 745                 750         


Ser Ser Glu Glu Glu Glu Gln Asp Asp Glu Glu Val Leu Gln Gly Glu 
        755                 760                 765             


Gln Gly Asp Phe Asn Asp Asp Asp Thr Glu Pro Glu Asn Leu Gly His 
    770                 775                 780                 


Arg Pro Leu Leu Met Asp Ser Glu Asp Glu Glu Glu Glu Glu Lys His 
785                 790                 795                 800 


Ser Ser Asp Ser Asp Tyr Glu Gln Ala Lys Ala Lys Tyr Ser Asp Met 
                805                 810                 815     


Ser Ser Val Tyr Arg Asp Arg Ser Gly Ser Gly Pro Thr Gln Asp Leu 
            820                 825                 830         


Asn Thr Ile Leu Leu Thr Ser Ala Gln Leu Ser Ser Asp Val Ala Val 
        835                 840                 845             


Glu Thr Pro Lys Gln Glu Phe Asp Val Phe Gly Ala Val Pro Phe Phe 
    850                 855                 860                 


Ala Val Arg Ala Gln Gln Pro Gln Gln Glu Lys Asn Glu Lys Asn Leu 
865                 870                 875                 880 


Pro Gln His Arg Phe Pro Ala Ala Gly Leu Glu Gln Glu Glu Phe Asp 
                885                 890                 895     


Val Phe Thr Lys Ala Pro Phe Ser Lys Lys Val Asn Val Gln Glu Cys 
            900                 905                 910         


His Ala Val Gly Pro Glu Ala His Thr Ile Pro Gly Tyr Pro Lys Ser 
        915                 920                 925             


Val Asp Val Phe Gly Ser Thr Pro Phe Gln Pro Phe Leu Thr Ser Thr 
    930                 935                 940                 


Ser Lys Ser Glu Ser Asn Glu Asp Leu Phe Gly Leu Val Pro Phe Asp 
945                 950                 955                 960 


Glu Ile Thr Gly Ser Gln Gln Gln Lys Val Lys Gln Arg Ser Leu Gln 
                965                 970                 975     


Lys Leu Ser Ser Arg Gln Arg Arg Thr Lys Gln Asp Met Ser Lys Ser 
            980                 985                 990         


Asn Gly Lys Arg His His Gly Thr  Pro Thr Ser Thr Lys  Lys Thr Leu 
        995                 1000                 1005             


Lys Pro  Thr Tyr Arg Thr Pro  Glu Arg Ala Arg Arg  His Lys Lys 
    1010                 1015                 1020             


Val Gly  Arg Arg Asp Ser Gln  Ser Ser Asn Glu Phe  Leu Thr Ile 
    1025                 1030                 1035             


Ser Asp  Ser Lys Glu Asn Ile  Ser Val Ala Leu Thr  Asp Gly Lys 
    1040                 1045                 1050             


Asp Arg  Gly Asn Val Leu Gln  Pro Glu Glu Ser Leu  Leu Asp Pro 
    1055                 1060                 1065             


Phe Gly  Ala Lys Pro Phe His  Ser Pro Asp Leu Ser  Trp His Pro 
    1070                 1075                 1080             


Pro His  Gln Gly Leu Ser Asp  Ile Arg Ala Asp His  Asn Thr Val 
    1085                 1090                 1095             


Leu Pro  Gly Arg Pro Arg Gln  Asn Ser Leu His Gly  Ser Phe His 
    1100                 1105                 1110             


Ser Ala  Asp Val Leu Lys Met  Asp Asp Phe Gly Ala  Val Pro Phe 
    1115                 1120                 1125             


Thr Glu  Leu Val Val Gln Ser  Ile Thr Pro His Gln  Ser Gln Gln 
    1130                 1135                 1140             


Ser Gln  Pro Val Glu Leu Asp  Pro Phe Gly Ala Ala  Pro Phe Pro 
    1145                 1150                 1155             


Ser Lys  Gln 
    1160     


