                         SEQUENCE LISTING

<110>  LYELL IMMUNOPHARMA, INC.
 
<120>  NR4A3-DEFICIENT CELLS EXPRESSING C-JUN AND USES THEREOF

<130>  4385.087PC02

<150>  US 63/195,956
<151>  2021-06-02

<150>  US 63/365,023
<151>  2022-05-19

<160>  123   

<170>  PatentIn version 3.5

<210>  1
<211>  626
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NR4A3 Isoform Alpha

<400>  1

Met Pro Cys Val Gln Ala Gln Tyr Ser Pro Ser Pro Pro Gly Ser Ser 
1               5                   10                  15      


Tyr Ala Ala Gln Thr Tyr Ser Ser Glu Tyr Thr Thr Glu Ile Met Asn 
            20                  25                  30          


Pro Asp Tyr Thr Lys Leu Thr Met Asp Leu Gly Ser Thr Glu Ile Thr 
        35                  40                  45              


Ala Thr Ala Thr Thr Ser Leu Pro Ser Ile Ser Thr Phe Val Glu Gly 
    50                  55                  60                  


Tyr Ser Ser Asn Tyr Glu Leu Lys Pro Ser Cys Val Tyr Gln Met Gln 
65                  70                  75                  80  


Arg Pro Leu Ile Lys Val Glu Glu Gly Arg Ala Pro Ser Tyr His His 
                85                  90                  95      


His His His His His His His His His His His His Gln Gln Gln His 
            100                 105                 110         


Gln Gln Pro Ser Ile Pro Pro Ala Ser Ser Pro Glu Asp Glu Val Leu 
        115                 120                 125             


Pro Ser Thr Ser Met Tyr Phe Lys Gln Ser Pro Pro Ser Thr Pro Thr 
    130                 135                 140                 


Thr Pro Ala Phe Pro Pro Gln Ala Gly Ala Leu Trp Asp Glu Ala Leu 
145                 150                 155                 160 


Pro Ser Ala Pro Gly Cys Ile Ala Pro Gly Pro Leu Leu Asp Pro Pro 
                165                 170                 175     


Met Lys Ala Val Pro Thr Val Ala Gly Ala Arg Phe Pro Leu Phe His 
            180                 185                 190         


Phe Lys Pro Ser Pro Pro His Pro Pro Ala Pro Ser Pro Ala Gly Gly 
        195                 200                 205             


His His Leu Gly Tyr Asp Pro Thr Ala Ala Ala Ala Leu Ser Leu Pro 
    210                 215                 220                 


Leu Gly Ala Ala Ala Ala Ala Gly Ser Gln Ala Ala Ala Leu Glu Ser 
225                 230                 235                 240 


His Pro Tyr Gly Leu Pro Leu Ala Lys Arg Ala Ala Pro Leu Ala Phe 
                245                 250                 255     


Pro Pro Leu Gly Leu Thr Pro Ser Pro Thr Ala Ser Ser Leu Leu Gly 
            260                 265                 270         


Glu Ser Pro Ser Leu Pro Ser Pro Pro Ser Arg Ser Ser Ser Ser Gly 
        275                 280                 285             


Glu Gly Thr Cys Ala Val Cys Gly Asp Asn Ala Ala Cys Gln His Tyr 
    290                 295                 300                 


Gly Val Arg Thr Cys Glu Gly Cys Lys Gly Phe Phe Lys Arg Thr Val 
305                 310                 315                 320 


Gln Lys Asn Ala Lys Tyr Val Cys Leu Ala Asn Lys Asn Cys Pro Val 
                325                 330                 335     


Asp Lys Arg Arg Arg Asn Arg Cys Gln Tyr Cys Arg Phe Gln Lys Cys 
            340                 345                 350         


Leu Ser Val Gly Met Val Lys Glu Val Val Arg Thr Asp Ser Leu Lys 
        355                 360                 365             


Gly Arg Arg Gly Arg Leu Pro Ser Lys Pro Lys Ser Pro Leu Gln Gln 
    370                 375                 380                 


Glu Pro Ser Gln Pro Ser Pro Pro Ser Pro Pro Ile Cys Met Met Asn 
385                 390                 395                 400 


Ala Leu Val Arg Ala Leu Thr Asp Ser Thr Pro Arg Asp Leu Asp Tyr 
                405                 410                 415     


Ser Arg Tyr Cys Pro Thr Asp Gln Ala Ala Ala Gly Thr Asp Ala Glu 
            420                 425                 430         


His Val Gln Gln Phe Tyr Asn Leu Leu Thr Ala Ser Ile Asp Val Ser 
        435                 440                 445             


Arg Ser Trp Ala Glu Lys Ile Pro Gly Phe Thr Asp Leu Pro Lys Glu 
    450                 455                 460                 


Asp Gln Thr Leu Leu Ile Glu Ser Ala Phe Leu Glu Leu Phe Val Leu 
465                 470                 475                 480 


Arg Leu Ser Ile Arg Ser Asn Thr Ala Glu Asp Lys Phe Val Phe Cys 
                485                 490                 495     


Asn Gly Leu Val Leu His Arg Leu Gln Cys Leu Arg Gly Phe Gly Glu 
            500                 505                 510         


Trp Leu Asp Ser Ile Lys Asp Phe Ser Leu Asn Leu Gln Ser Leu Asn 
        515                 520                 525             


Leu Asp Ile Gln Ala Leu Ala Cys Leu Ser Ala Leu Ser Met Ile Thr 
    530                 535                 540                 


Glu Arg His Gly Leu Lys Glu Pro Lys Arg Val Glu Glu Leu Cys Asn 
545                 550                 555                 560 


Lys Ile Thr Ser Ser Leu Lys Asp His Gln Ser Lys Gly Gln Ala Leu 
                565                 570                 575     


Glu Pro Thr Glu Ser Lys Val Leu Gly Ala Leu Val Glu Leu Arg Lys 
            580                 585                 590         


Ile Cys Thr Leu Gly Leu Gln Arg Ile Phe Tyr Leu Lys Leu Glu Asp 
        595                 600                 605             


Leu Val Ser Pro Pro Ser Ile Ile Asp Lys Leu Phe Leu Asp Thr Leu 
    610                 615                 620                 


Pro Phe 
625     


<210>  2
<211>  443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NR4A3 Isoform Beta

<400>  2

Met Pro Cys Val Gln Ala Gln Tyr Ser Pro Ser Pro Pro Gly Ser Ser 
1               5                   10                  15      


Tyr Ala Ala Gln Thr Tyr Ser Ser Glu Tyr Thr Thr Glu Ile Met Asn 
            20                  25                  30          


Pro Asp Tyr Thr Lys Leu Thr Met Asp Leu Gly Ser Thr Glu Ile Thr 
        35                  40                  45              


Ala Thr Ala Thr Thr Ser Leu Pro Ser Ile Ser Thr Phe Val Glu Gly 
    50                  55                  60                  


Tyr Ser Ser Asn Tyr Glu Leu Lys Pro Ser Cys Val Tyr Gln Met Gln 
65                  70                  75                  80  


Arg Pro Leu Ile Lys Val Glu Glu Gly Arg Ala Pro Ser Tyr His His 
                85                  90                  95      


His His His His His His His His His His His His Gln Gln Gln His 
            100                 105                 110         


Gln Gln Pro Ser Ile Pro Pro Ala Ser Ser Pro Glu Asp Glu Val Leu 
        115                 120                 125             


Pro Ser Thr Ser Met Tyr Phe Lys Gln Ser Pro Pro Ser Thr Pro Thr 
    130                 135                 140                 


Thr Pro Ala Phe Pro Pro Gln Ala Gly Ala Leu Trp Asp Glu Ala Leu 
145                 150                 155                 160 


Pro Ser Ala Pro Gly Cys Ile Ala Pro Gly Pro Leu Leu Asp Pro Pro 
                165                 170                 175     


Met Lys Ala Val Pro Thr Val Ala Gly Ala Arg Phe Pro Leu Phe His 
            180                 185                 190         


Phe Lys Pro Ser Pro Pro His Pro Pro Ala Pro Ser Pro Ala Gly Gly 
        195                 200                 205             


His His Leu Gly Tyr Asp Pro Thr Ala Ala Ala Ala Leu Ser Leu Pro 
    210                 215                 220                 


Leu Gly Ala Ala Ala Ala Ala Gly Ser Gln Ala Ala Ala Leu Glu Ser 
225                 230                 235                 240 


His Pro Tyr Gly Leu Pro Leu Ala Lys Arg Ala Ala Pro Leu Ala Phe 
                245                 250                 255     


Pro Pro Leu Gly Leu Thr Pro Ser Pro Thr Ala Ser Ser Leu Leu Gly 
            260                 265                 270         


Glu Ser Pro Ser Leu Pro Ser Pro Pro Ser Arg Ser Ser Ser Ser Gly 
        275                 280                 285             


Glu Gly Thr Cys Ala Val Cys Gly Asp Asn Ala Ala Cys Gln His Tyr 
    290                 295                 300                 


Gly Val Arg Thr Cys Glu Gly Cys Lys Gly Phe Phe Lys Arg Thr Val 
305                 310                 315                 320 


Gln Lys Asn Ala Lys Tyr Val Cys Leu Ala Asn Lys Asn Cys Pro Val 
                325                 330                 335     


Asp Lys Arg Arg Arg Asn Arg Cys Gln Tyr Cys Arg Phe Gln Lys Cys 
            340                 345                 350         


Leu Ser Val Gly Met Val Lys Glu Val Val Arg Thr Asp Ser Leu Lys 
        355                 360                 365             


Gly Arg Arg Gly Arg Leu Pro Ser Lys Pro Lys Ser Pro Leu Gln Gln 
    370                 375                 380                 


Glu Pro Ser Gln Pro Ser Pro Pro Ser Pro Pro Ile Cys Met Met Asn 
385                 390                 395                 400 


Ala Leu Val Arg Ala Leu Thr Asp Ser Thr Pro Arg Asp Leu Asp Tyr 
                405                 410                 415     


Ser Arg Val Ser Phe Met Ile Ser Cys Phe Gln Met Asn Asp Gln Gly 
            420                 425                 430         


Leu Tyr Leu Trp Leu Leu Val Ile Arg Val Asp 
        435                 440             


<210>  3
<211>  637
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NR4A3 Isoform 3

<400>  3

Met His Asp Ser Ile Arg Phe Gly Asn Val Asp Met Pro Cys Val Gln 
1               5                   10                  15      


Ala Gln Tyr Ser Pro Ser Pro Pro Gly Ser Ser Tyr Ala Ala Gln Thr 
            20                  25                  30          


Tyr Ser Ser Glu Tyr Thr Thr Glu Ile Met Asn Pro Asp Tyr Thr Lys 
        35                  40                  45              


Leu Thr Met Asp Leu Gly Ser Thr Glu Ile Thr Ala Thr Ala Thr Thr 
    50                  55                  60                  


Ser Leu Pro Ser Ile Ser Thr Phe Val Glu Gly Tyr Ser Ser Asn Tyr 
65                  70                  75                  80  


Glu Leu Lys Pro Ser Cys Val Tyr Gln Met Gln Arg Pro Leu Ile Lys 
                85                  90                  95      


Val Glu Glu Gly Arg Ala Pro Ser Tyr His His His His His His His 
            100                 105                 110         


His His His His His His His Gln Gln Gln His Gln Gln Pro Ser Ile 
        115                 120                 125             


Pro Pro Ala Ser Ser Pro Glu Asp Glu Val Leu Pro Ser Thr Ser Met 
    130                 135                 140                 


Tyr Phe Lys Gln Ser Pro Pro Ser Thr Pro Thr Thr Pro Ala Phe Pro 
145                 150                 155                 160 


Pro Gln Ala Gly Ala Leu Trp Asp Glu Ala Leu Pro Ser Ala Pro Gly 
                165                 170                 175     


Cys Ile Ala Pro Gly Pro Leu Leu Asp Pro Pro Met Lys Ala Val Pro 
            180                 185                 190         


Thr Val Ala Gly Ala Arg Phe Pro Leu Phe His Phe Lys Pro Ser Pro 
        195                 200                 205             


Pro His Pro Pro Ala Pro Ser Pro Ala Gly Gly His His Leu Gly Tyr 
    210                 215                 220                 


Asp Pro Thr Ala Ala Ala Ala Leu Ser Leu Pro Leu Gly Ala Ala Ala 
225                 230                 235                 240 


Ala Ala Gly Ser Gln Ala Ala Ala Leu Glu Ser His Pro Tyr Gly Leu 
                245                 250                 255     


Pro Leu Ala Lys Arg Ala Ala Pro Leu Ala Phe Pro Pro Leu Gly Leu 
            260                 265                 270         


Thr Pro Ser Pro Thr Ala Ser Ser Leu Leu Gly Glu Ser Pro Ser Leu 
        275                 280                 285             


Pro Ser Pro Pro Ser Arg Ser Ser Ser Ser Gly Glu Gly Thr Cys Ala 
    290                 295                 300                 


Val Cys Gly Asp Asn Ala Ala Cys Gln His Tyr Gly Val Arg Thr Cys 
305                 310                 315                 320 


Glu Gly Cys Lys Gly Phe Phe Lys Arg Thr Val Gln Lys Asn Ala Lys 
                325                 330                 335     


Tyr Val Cys Leu Ala Asn Lys Asn Cys Pro Val Asp Lys Arg Arg Arg 
            340                 345                 350         


Asn Arg Cys Gln Tyr Cys Arg Phe Gln Lys Cys Leu Ser Val Gly Met 
        355                 360                 365             


Val Lys Glu Val Val Arg Thr Asp Ser Leu Lys Gly Arg Arg Gly Arg 
    370                 375                 380                 


Leu Pro Ser Lys Pro Lys Ser Pro Leu Gln Gln Glu Pro Ser Gln Pro 
385                 390                 395                 400 


Ser Pro Pro Ser Pro Pro Ile Cys Met Met Asn Ala Leu Val Arg Ala 
                405                 410                 415     


Leu Thr Asp Ser Thr Pro Arg Asp Leu Asp Tyr Ser Arg Tyr Cys Pro 
            420                 425                 430         


Thr Asp Gln Ala Ala Ala Gly Thr Asp Ala Glu His Val Gln Gln Phe 
        435                 440                 445             


Tyr Asn Leu Leu Thr Ala Ser Ile Asp Val Ser Arg Ser Trp Ala Glu 
    450                 455                 460                 


Lys Ile Pro Gly Phe Thr Asp Leu Pro Lys Glu Asp Gln Thr Leu Leu 
465                 470                 475                 480 


Ile Glu Ser Ala Phe Leu Glu Leu Phe Val Leu Arg Leu Ser Ile Arg 
                485                 490                 495     


Ser Asn Thr Ala Glu Asp Lys Phe Val Phe Cys Asn Gly Leu Val Leu 
            500                 505                 510         


His Arg Leu Gln Cys Leu Arg Gly Phe Gly Glu Trp Leu Asp Ser Ile 
        515                 520                 525             


Lys Asp Phe Ser Leu Asn Leu Gln Ser Leu Asn Leu Asp Ile Gln Ala 
    530                 535                 540                 


Leu Ala Cys Leu Ser Ala Leu Ser Met Ile Thr Glu Arg His Gly Leu 
545                 550                 555                 560 


Lys Glu Pro Lys Arg Val Glu Glu Leu Cys Asn Lys Ile Thr Ser Ser 
                565                 570                 575     


Leu Lys Asp His Gln Ser Lys Gly Gln Ala Leu Glu Pro Thr Glu Ser 
            580                 585                 590         


Lys Val Leu Gly Ala Leu Val Glu Leu Arg Lys Ile Cys Thr Leu Gly 
        595                 600                 605             


Leu Gln Arg Ile Phe Tyr Leu Lys Leu Glu Asp Leu Val Ser Pro Pro 
    610                 615                 620                 


Ser Ile Ile Asp Lys Leu Phe Leu Asp Thr Leu Pro Phe 
625                 630                 635         


<210>  4
<211>  331
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Wild-type human c-Jun

<400>  4

Met Thr Ala Lys Met Glu Thr Thr Phe Tyr Asp Asp Ala Leu Asn Ala 
1               5                   10                  15      


Ser Phe Leu Pro Ser Glu Ser Gly Pro Tyr Gly Tyr Ser Asn Pro Lys 
            20                  25                  30          


Ile Leu Lys Gln Ser Met Thr Leu Asn Leu Ala Asp Pro Val Gly Ser 
        35                  40                  45              


Leu Lys Pro His Leu Arg Ala Lys Asn Ser Asp Leu Leu Thr Ser Pro 
    50                  55                  60                  


Asp Val Gly Leu Leu Lys Leu Ala Ser Pro Glu Leu Glu Arg Leu Ile 
65                  70                  75                  80  


Ile Gln Ser Ser Asn Gly His Ile Thr Thr Thr Pro Thr Pro Thr Gln 
                85                  90                  95      


Phe Leu Cys Pro Lys Asn Val Thr Asp Glu Gln Glu Gly Phe Ala Glu 
            100                 105                 110         


Gly Phe Val Arg Ala Leu Ala Glu Leu His Ser Gln Asn Thr Leu Pro 
        115                 120                 125             


Ser Val Thr Ser Ala Ala Gln Pro Val Asn Gly Ala Gly Met Val Ala 
    130                 135                 140                 


Pro Ala Val Ala Ser Val Ala Gly Gly Ser Gly Ser Gly Gly Phe Ser 
145                 150                 155                 160 


Ala Ser Leu His Ser Glu Pro Pro Val Tyr Ala Asn Leu Ser Asn Phe 
                165                 170                 175     


Asn Pro Gly Ala Leu Ser Ser Gly Gly Gly Ala Pro Ser Tyr Gly Ala 
            180                 185                 190         


Ala Gly Leu Ala Phe Pro Ala Gln Pro Gln Gln Gln Gln Gln Pro Pro 
        195                 200                 205             


His His Leu Pro Gln Gln Met Pro Val Gln His Pro Arg Leu Gln Ala 
    210                 215                 220                 


Leu Lys Glu Glu Pro Gln Thr Val Pro Glu Met Pro Gly Glu Thr Pro 
225                 230                 235                 240 


Pro Leu Ser Pro Ile Asp Met Glu Ser Gln Glu Arg Ile Lys Ala Glu 
                245                 250                 255     


Arg Lys Arg Met Arg Asn Arg Ile Ala Ala Ser Lys Cys Arg Lys Arg 
            260                 265                 270         


Lys Leu Glu Arg Ile Ala Arg Leu Glu Glu Lys Val Lys Thr Leu Lys 
        275                 280                 285             


Ala Gln Asn Ser Glu Leu Ala Ser Thr Ala Asn Met Leu Arg Glu Gln 
    290                 295                 300                 


Val Ala Gln Leu Lys Gln Lys Val Met Asn His Val Asn Ser Gly Cys 
305                 310                 315                 320 


Gln Leu Met Leu Thr Gln Gln Leu Gln Thr Phe 
                325                 330     


<210>  5
<211>  3257
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Wild-type human c-Jun

<400>  5
gctcagagtt gcactgagtg tggctgaagc agcgaggcgg gagtggaggt gcgcggagtc       60

aggcagacag acagacacag ccagccagcc aggtcggcag tatagtccga actgcaaatc      120

ttattttctt ttcaccttct ctctaactgc ccagagctag cgcctgtggc tcccgggctg      180

gtgtttcggg agtgtccaga gagcctggtc tccagccgcc cccgggagga gagccctgct      240

gcccaggcgc tgttgacagc ggcggaaagc agcggtaccc acgcgcccgc cgggggaagt      300

cggcgagcgg ctgcagcagc aaagaacttt cccggctggg aggaccggag acaagtggca      360

gagtcccgga gccaactttt gcaagccttt cctgcgtctt aggcttctcc acggcggtaa      420

agaccagaag gcggcggaga gccacgcaag agaagaagga cgtgcgctca gcttcgctcg      480

caccggttgt tgaacttggg cgagcgcgag ccgcggctgc cgggcgcccc ctccccctag      540

cagcggagga ggggacaagt cgtcggagtc cgggcggcca agacccgccg ccggccggcc      600

actgcagggt ccgcactgat ccgctccgcg gggagagccg ctgctctggg aagtgagttc      660

gcctgcggac tccgaggaac cgctgcgcac gaagagcgct cagtgagtga ccgcgacttt      720

tcaaagccgg gtagcgcgcg cgagtcgaca agtaagagtg cgggaggcat cttaattaac      780

cctgcgctcc ctggagcgag ctggtgagga gggcgcagcg gggacgacag ccagcgggtg      840

cgtgcgctct tagagaaact ttccctgtca aaggctccgg ggggcgcggg tgtcccccgc      900

ttgccacagc cctgttgcgg ccccgaaact tgtgcgcgca gcccaaacta acctcacgtg      960

aagtgacgga ctgttctatg actgcaaaga tggaaacgac cttctatgac gatgccctca     1020

acgcctcgtt cctcccgtcc gagagcggac cttatggcta cagtaacccc aagatcctga     1080

aacagagcat gaccctgaac ctggccgacc cagtggggag cctgaagccg cacctccgcg     1140

ccaagaactc ggacctcctc acctcgcccg acgtggggct gctcaagctg gcgtcgcccg     1200

agctggagcg cctgataatc cagtccagca acgggcacat caccaccacg ccgaccccca     1260

cccagttcct gtgccccaag aacgtgacag atgagcagga gggcttcgcc gagggcttcg     1320

tgcgcgccct ggccgaactg cacagccaga acacgctgcc cagcgtcacg tcggcggcgc     1380

agccggtcaa cggggcaggc atggtggctc ccgcggtagc ctcggtggca gggggcagcg     1440

gcagcggcgg cttcagcgcc agcctgcaca gcgagccgcc ggtctacgca aacctcagca     1500

acttcaaccc aggcgcgctg agcagcggcg gcggggcgcc ctcctacggc gcggccggcc     1560

tggcctttcc cgcgcaaccc cagcagcagc agcagccgcc gcaccacctg ccccagcaga     1620

tgcccgtgca gcacccgcgg ctgcaggccc tgaaggagga gcctcagaca gtgcccgaga     1680

tgcccggcga gacaccgccc ctgtccccca tcgacatgga gtcccaggag cggatcaagg     1740

cggagaggaa gcgcatgagg aaccgcatcg ctgcctccaa gtgccgaaaa aggaagctgg     1800

agagaatcgc ccggctggag gaaaaagtga aaaccttgaa agctcagaac tcggagctgg     1860

cgtccacggc caacatgctc agggaacagg tggcacagct taaacagaaa gtcatgaacc     1920

acgttaacag tgggtgccaa ctcatgctaa cgcagcagtt gcaaacattt tgaagagaga     1980

ccgtcggggg ctgaggggca acgaagaaaa aaaataacac agagagacag acttgagaac     2040

ttgacaagtt gcgacggaga gaaaaaagaa gtgtccgaga actaaagcca agggtatcca     2100

agttggactg ggttgcgtcc tgacggcgcc cccagtgtgc acgagtggga aggacttggc     2160

gcgccctccc ttggcgtgga gccagggagc ggccgcctgc gggctgcccc gctttgcgga     2220

cgggctgtcc ccgcgcgaac ggaacgttgg acttttcgtt aacattgacc aagaactgca     2280

tggacctaac attcgatctc attcagtatt aaagggggga gggggagggg gttacaaact     2340

gcaatagaga ctgtagattg cttctgtagt actccttaag aacacaaagc ggggggaggg     2400

ttggggaggg gcggcaggag ggaggtttgt gagagcgagg ctgagcctac agatgaactc     2460

tttctggcct gccttcgtta actgtgtatg tacatatata tattttttaa tttgatgaaa     2520

gctgattact gtcaataaac agcttcatgc ctttgtaagt tatttcttgt ttgtttgttt     2580

gggtatcctg cccagtgttg tttgtaaata agagatttgg agcactctga gtttaccatt     2640

tgtaataaag tatataattt ttttatgttt tgtttctgaa aattccagaa aggatattta     2700

agaaaataca ataaactatt ggaaagtact cccctaacct cttttctgca tcatctgtag     2760

atactagcta tctaggtgga gttgaaagag ttaagaatgt cgattaaaat cactctcagt     2820

gcttcttact attaagcagt aaaaactgtt ctctattaga ctttagaaat aaatgtacct     2880

gatgtacctg atgctatggt caggttatac tcctcctccc ccagctatct atatggaatt     2940

gcttaccaaa ggatagtgcg atgtttcagg aggctggagg aaggggggtt gcagtggaga     3000

gggacagccc actgagaagt caaacatttc aaagtttgga ttgtatcaag tggcatgtgc     3060

tgtgaccatt tataatgtta gtagaaattt tacaataggt gcttattctc aaagcaggaa     3120

ttggtggcag attttacaaa agatgtatcc ttccaatttg gaatcttctc tttgacaatt     3180

cctagataaa aagatggcct ttgcttatga atatttataa cagcattctt gtcacaataa     3240

atgtattcaa ataccaa                                                    3257


<210>  6
<211>  993
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Wild-type human c-Jun (coding region)

<400>  6
atgactgcaa agatggaaac gaccttctat gacgatgccc tcaacgcctc gttcctcccg       60

tccgagagcg gaccttatgg ctacagtaac cccaagatcc tgaaacagag catgaccctg      120

aacctggccg acccagtggg gagcctgaag ccgcacctcc gcgccaagaa ctcggacctc      180

ctcacctcgc ccgacgtggg gctgctcaag ctggcgtcgc ccgagctgga gcgcctgata      240

atccagtcca gcaacgggca catcaccacc acgccgaccc ccacccagtt cctgtgcccc      300

aagaacgtga cagatgagca ggagggcttc gccgagggct tcgtgcgcgc cctggccgaa      360

ctgcacagcc agaacacgct gcccagcgtc acgtcggcgg cgcagccggt caacggggca      420

ggcatggtgg ctcccgcggt agcctcggtg gcagggggca gcggcagcgg cggcttcagc      480

gccagcctgc acagcgagcc gccggtctac gcaaacctca gcaacttcaa cccaggcgcg      540

ctgagcagcg gcggcggggc gccctcctac ggcgcggccg gcctggcctt tcccgcgcaa      600

ccccagcagc agcagcagcc gccgcaccac ctgccccagc agatgcccgt gcagcacccg      660

cggctgcagg ccctgaagga ggagcctcag acagtgcccg agatgcccgg cgagacaccg      720

cccctgtccc ccatcgacat ggagtcccag gagcggatca aggcggagag gaagcgcatg      780

aggaaccgca tcgctgcctc caagtgccga aaaaggaagc tggagagaat cgcccggctg      840

gaggaaaaag tgaaaacctt gaaagctcag aactcggagc tggcgtccac ggccaacatg      900

ctcagggaac aggtggcaca gcttaaacag aaagtcatga accacgttaa cagtgggtgc      960

caactcatgc taacgcagca gttgcaaaca ttt                                   993


<210>  7
<211>  993
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  c-Jun codon optimized #1

<400>  7
atgacagcca agatggaaac cacattctac gacgacgccc tgaacgcctc attcctgcct       60

tctgagagcg gaccttacgg ctacagcaat cctaagatcc tgaaacagag catgaccctt      120

aacctggctg atcctgttgg aagcctgaaa cctcacctga gagccaaaaa cagcgacctg      180

ctcaccagcc ctgatgtggg cctgctgaag ctggcctctc cagagctgga acggctgatc      240

atccagagca gcaacggcca catcacaacc acccctaccc ctacacaatt cctgtgccct      300

aagaacgtga ccgacgagca ggagggcttc gccgaaggct ttgtgcgggc cctggcagaa      360

ctgcactctc agaacaccct gcctagcgtg acctccgccg cccagcctgt caacggcgcc      420

ggaatggtgg cccctgccgt ggcttctgtg gccggcggca gcggcagcgg cggattcagc      480

gcctctctgc actctgagcc tcctgtctac gccaatctgt ctaatttcaa ccccggagcc      540

ctgtccagcg gcggcggagc tcctagctac ggcgctgctg gactggcctt ccccgcccag      600

ccccagcaac agcagcagcc tccacaccac ctgccccagc agatgcccgt gcagcaccct      660

agactgcagg ccctgaagga agaaccccaa acagtgcctg agatgcctgg cgagacacct      720

ccactgagcc ccatcgacat ggaaagccag gagcggatca aggccgagag aaagagaatg      780

cggaacagaa tcgccgctag caagtgcaga aagcggaagc tggaaagaat cgccagactg      840

gaagagaagg tgaagaccct gaaagcccaa aatagcgagc tggccagcac cgccaacatg      900

ctgcgggaac aggtggccca gctgaagcag aaggtgatga accacgtgaa ctctggttgt      960

cagctgatgc tgacccagca gctccagacc ttc                                   993


<210>  8
<211>  993
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  c-Jun codon optimized #2

<400>  8
atgacagcca agatggaaac caccttctac gacgacgccc tcaacgcctc cttcctgcct       60

tctgagagcg gtccttacgg ctacagcaac cccaagatcc tgaagcaaag catgaccctg      120

aacctggccg accccgttgg ctccctgaaa cctcacctga gagccaaaaa cagcgacctg      180

ctgaccagcc ctgatgtggg cctgctgaag ctggcctctc cagagctgga aagactgatt      240

atccagagca gcaacggcca catcaccaca acacctaccc ctacacagtt cctgtgccct      300

aagaacgtga ctgatgagca ggagggcttt gccgagggct tcgtgagagc cctggctgag      360

ctgcattctc agaacaccct gcctagcgtg acctctgccg cccagcctgt taatggcgcc      420

ggcatggtgg cccctgccgt ggcctctgtg gccggaggca gcggcagcgg cggattcagc      480

gcctctctgc acagcgagcc ccccgtctac gccaacctga gcaatttcaa ccctggcgcc      540

ctgtccagcg gcggcggcgc cccttcatat ggcgctgccg gcctggcctt ccccgctcag      600

ccccagcagc agcaacagcc tccacaccac ctgccccagc agatgcccgt gcagcacccc      660

agactgcagg ccctgaagga agaacctcag accgtgcccg agatgcctgg cgagacccct      720

cctctgagcc ctatcgacat ggaaagccag gagagaatca aggccgagag gaagcggatg      780

cggaacagaa tcgccgccag caagtgcaga aaaagaaagc tggaacggat cgccagactg      840

gaggagaagg tgaagacact gaaagcccaa aattctgaac tggcctctac cgccaatatg      900

ctgcgcgagc aggtggctca actgaagcag aaggtgatga accacgtgaa cagcggatgt      960

cagctgatgc tgacacagca gctgcagact ttt                                   993


<210>  9
<211>  993
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  c-Jun codon optimized #3

<400>  9
atgaccgcca agatggaaac caccttctac gacgacgccc tgaacgccag ctttctgcct       60

tctgagtctg gcccctacgg ctacagcaac cccaagatcc tgaagcagag catgaccctg      120

aacctggccg atcctgtggg cagcctgaaa cctcacctga gagccaagaa cagcgacctg      180

ctgacaagcc ctgatgtggg cctgctgaaa ctggcctctc ctgagctgga acggctgatc      240

atccagagca gcaacggcca catcaccacc acacctacac caacacagtt tctgtgcccc      300

aagaacgtga ccgacgagca agagggattc gccgagggct ttgttagagc cctggccgaa      360

ctgcacagcc agaataccct gcctagcgtg acatctgccg ctcagcctgt taatggcgcc      420

ggaatggttg ctcctgccgt ggcttctgtt gctggcggat ctggatctgg cggctttagc      480

gcctctctgc actctgagcc tccagtgtac gccaacctga gcaacttcaa ccctggcgct      540

cttagctctg gtggcggagc accttcttat ggcgctgccg gattggcctt tcctgctcag      600

cctcagcagc agcaacagcc tcctcatcat ctgccccagc agatgcctgt gcagcaccct      660

agactgcagg ccctgaaaga ggaaccccag acagtccctg agatgcccgg cgaaacacct      720

cctctgagcc ccatcgacat ggaaagccaa gagcggatca aggccgagcg gaagcggatg      780

agaaatagaa tcgccgcctc caagtgccgg aagaggaagc tggaaagaat cgcccggctg      840

gaagagaaag tgaaaaccct gaaggcccag aactccgagc tggcctctac cgccaacatg      900

ctgagagaac aggtggccca gctgaaacag aaagtcatga accacgtgaa cagcggctgc      960

cagctgatgc tgacacagca gctgcagacc ttc                                   993


<210>  10
<211>  993
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  c-Jun codon optimized #4

<400>  10
atgactgcca aaatggagac tacattctat gacgacgccc tcaatgccag ttttttgccg       60

agtgaatccg gcccctacgg ctattcaaac cctaagatcc tcaagcaatc aatgaccctc      120

aatcttgctg acccagttgg ctccctgaaa ccccatctca gagctaaaaa tagtgacctc      180

cttacttccc ctgatgttgg actcctcaaa cttgcttctc ccgaactcga acgcttgatc      240

attcaatctt ccaacggcca catcacaaca acacccacac ccacccagtt tctttgccca      300

aaaaatgtca ccgatgaaca ggaaggtttc gcggaaggat tcgtccgcgc gctggccgaa      360

ctgcactccc agaatacact tccttcagtt acgtcagccg cccagccagt gaatggtgcg      420

ggaatggttg ctcctgcggt cgcttctgtc gcagggggct ccggttctgg cggatttagc      480

gcctctctgc attccgagcc acctgtatat gctaatcttt ctaattttaa ccccggagcc      540

ttgtctagcg gcggtggtgc ccccagctac ggtgctgcag gactcgcctt cccagctcaa      600

cctcagcagc agcaacaacc cccccatcac cttccccaac agatgccagt acaacatcca      660

aggctccagg ccctcaaaga ggaaccacag acggtgcccg aaatgcctgg cgaaactcca      720

ccactttccc ctattgatat ggaatcccaa gagcgcatca aggccgaaag aaagcgaatg      780

cggaatagaa tagcagcttc aaaatgtaga aaacggaaat tggaacgaat cgcacggttg      840

gaagaaaagg tgaagacctt gaaagcccag aacagtgagc tcgcctctac cgctaacatg      900

ctgcgcgagc aagtcgcaca acttaagcag aaggtgatga accatgtgaa tagcggatgt      960

caacttatgc tgactcaaca gttgcaaacc ttt                                   993


<210>  11
<211>  993
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  c-Jun codon optimized #5

<400>  11
atgaccgcga aaatggagac aacattttac gatgatgcac tgaacgcctc ttttctgcca       60

agtgaatccg gcccctacgg atactcaaac cctaagattc tgaaacagtc tatgactctc      120

aacctggccg acccagttgg cagtctgaag cctcatttgc gagccaagaa tagtgatctg      180

ctgacctccc cagacgtggg actgctgaaa ctcgcctcac ctgaacttga gcgcttgatt      240

atacagtcat ccaatgggca catcacaaca acacctactc ctacccagtt tctgtgcccc      300

aaaaacgtca ccgatgagca ggagggattc gcggaaggct ttgtgcgcgc cctggctgaa      360

ttgcatagtc agaacactct tcccagcgta accagcgccg cccaaccagt gaatggagcc      420

ggtatggtgg ctcccgcggt ggctagtgtt gcgggggggt caggctctgg tgggttcagt      480

gcttctcttc actctgaacc ccctgtgtat gccaatctgt ctaactttaa ccctggggcc      540

ctctcctctg gtgggggtgc ccccagctac ggagcggccg gcctggcctt tcctgcccag      600

cctcagcagc agcagcaacc ccctcatcat cttccgcagc agatgccagt acagcatcca      660

cgcctgcagg ctcttaagga ggagccccag acggtgcccg aaatgcccgg ggaaactcca      720

cccttgtccc ccattgacat ggagtcccag gagcggatca aggctgaaag aaagaggatg      780

cggaatcgca tcgcagcctc taaatgccgc aagcggaaac ttgagaggat cgcgcggttg      840

gaggaaaaag taaaaacctt gaaggcacag aactctgagc tggcgagtac tgccaacatg      900

ctcagagaac aagtcgcaca gctgaagcag aaagtgatga accatgtgaa cagcggttgt      960

cagctgatgc tgactcagca gctgcagacc ttc                                   993


<210>  12
<211>  993
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  c-Jun codon optimized #6

<400>  12
atgaccgcca agatggagac cacattctac gatgacgctc tgaacgcttc ctttctgcct       60

tccgagtccg gcccctacgg ctactccaat cccaagattc tgaagcagag catgacactg      120

aatctggctg atcccgtggg atctctgaag cctcatctga gagccaagaa ttccgatctg      180

ctgacaagcc ccgacgtggg actgctcaaa ctggccagcc ccgaactgga gaggctcatt      240

atccagagct ccaacggcca catcaccaca acacctaccc ctacccagtt tctctgtccc      300

aagaacgtga cagacgagca agagggattt gccgaaggct tcgtgagagc cctcgccgaa      360

ctgcatagcc agaacacact gccttccgtg accagcgctg ctcaacccgt gaacggcgct      420

ggcatggtcg ctcccgccgt cgccagcgtg gctggaggaa gcggatccgg aggcttcagc      480

gcttccctcc acagcgaacc tcccgtgtac gctaatctga gcaacttcaa ccccggcgct      540

ctgagcagcg gaggaggagc tcctagctat ggagctgccg gactggcttt tcccgcccag      600

ccccagcagc agcagcagcc cccccatcat ctgcctcagc agatgcccgt gcagcatccc      660

agactccaag ctctgaagga ggagcctcag accgtccccg agatgcccgg cgaaaccccc      720

cctctgtccc ccatcgacat ggaaagccaa gagaggatca aggccgagag gaagaggatg      780

aggaatagaa tcgccgccag caagtgtaga aagaggaagc tggagaggat cgccagactg      840

gaggagaagg tgaagaccct caaggctcag aattccgagc tggccagcac agccaacatg      900

ctgagagagc aagtggccca gctcaagcag aaggtgatga accacgtcaa cagcggatgc      960

cagctgatgc tcacccagca gctgcagacc ttc                                   993


<210>  13
<211>  993
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  c-Jun codon optimized #7

<400>  13
atgaccgcta aaatggaaac cactttctat gacgatgccc tgaacgcctc cttccttccg       60

tccgagtccg gaccctacgg atactcaaat cctaagatcc tcaaacagtc gatgaccctc      120

aacctggccg accccgtggg atccctgaag ccgcacttgc gcgccaagaa ctccgacctc      180

ctgacgagcc cagacgtggg cctgctgaag ctcgcatcac ccgaacttga gcggttgatc      240

attcagtcct ccaacggaca tatcaccacc actcccaccc caactcagtt tctgtgtccg      300

aagaacgtga ccgatgagca agagggattc gccgagggat tcgtgcgggc cctggccgag      360

ctgcatagcc agaacaccct tccatccgtg acctcggcgg ctcagcctgt gaacggcgcg      420

ggaatggtcg cgcccgccgt ggcctcggtg gccgggggca gcggcagcgg gggattttcc      480

gcgtcgctgc actccgagcc gccggtgtac gccaacctgt caaacttcaa ccctggggcc      540

ctgagctccg gcggtggagc accttcgtac ggcgccgctg gcctggcgtt ccccgcgcaa      600

ccacagcagc aacagcagcc ccctcaccac ctcccccaac aaatgcctgt gcagcacccg      660

aggctgcagg ccctcaagga agaaccccag actgtgccgg aaatgccggg ggagactccg      720

ccgctgtccc ctatcgacat ggaatcacag gaacgcatta aggcagagcg gaagcgcatg      780

cggaaccgga ttgccgcctc caagtgccgc aagagaaagc tcgaaagaat cgccagattg      840

gaagaaaagg tcaagactct gaaggcccag aactctgagc tggcatccac cgctaatatg      900

ctgagggaac aagtggccca gctgaaacag aaggtcatga accacgtcaa cagcggttgc      960

cagctgatgc tgacccagca actccagaca ttc                                   993


<210>  14
<211>  993
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  c-Jun codon optimized #8

<400>  14
atgaccgcca agatggagac caccttctac gacgacgccc tgaacgccag cttcctgccc       60

agcgagagcg gaccctacgg ctactctaac cccaagatcc tgaaacagag catgacactg      120

aatctggccg accccgtggg cagcctgaag cctcacctta gagccaagaa cagcgacctg      180

ctgaccagcc ccgacgtggg cctgctgaag ctcgcctctc cagagttaga gagactgatc      240

atccagtcca gcaacggcca catcacaacc accccaaccc ctacccagtt cctgtgcccc      300

aagaacgtga ccgacgagca ggagggcttc gccgagggct ttgtgagagc cctggccgag      360

ttgcactctc agaacaccct gccctccgtg accagcgccg ctcaacctgt gaacggcgca      420

ggaatggttg ctcctgccgt ggccagcgtt gcaggcggat ctggaagtgg aggcttctcc      480

gcctcccttc acagcgagcc tcccgtgtac gccaacctga gcaacttcaa ccccggcgcc      540

ctgagcagtg gaggaggcgc tcccagctat ggagcagctg gattagcctt ccccgcccag      600

ccacagcagc agcaacagcc tccccaccac ctgcctcagc aaatgcctgt gcagcaccct      660

cggctgcagg cccttaagga ggagccccag accgttcctg agatgcctgg cgagacccct      720

cccctgagcc ctatcgacat ggagtcccag gagcggatca aggccgagcg gaagcggatg      780

cggaaccgga tcgctgcttc caagtgccgg aagagaaagc tggagagaat cgcccggctg      840

gaggagaagg tgaagaccct gaaggcccag aactccgagc tggcctccac cgccaacatg      900

ctgcgggagc aggttgcaca gctgaagcag aaggtcatga accacgtgaa cagcggctgc      960

cagctgatgc tgacccagca gctgcagacc ttc                                   993


<210>  15
<211>  1059
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  c-Jun codon optimized #9

<400>  15
atgacagcga agatggagac aaccttctat gacgatgctc ttaacgcctc cttcctgcct       60

tccgaaagcg ggccctacgg gtactctaat cctaagatac ttaagcaatc gatgactctc      120

aacctcgctg acccggttgg ctcactgaaa ccacacctga gagctaagaa tagtgacctg      180

ctcactagtc ccgatgtcgg gcttctgaag ctggcctctc ccgagctgga gaggcttatc      240

atccaatcat caaatggcca catcaccact accccaacac caactcaatt cctttgccct      300

aaaaacgtga ccgacgaaca ggaaggcttc gccgagggtt ttgtccgggc cttggccgag      360

ctgcattctc aaaatacact gccaagcgtc acttctgcgg cgcagccggt taacggagca      420

gggatggtgg ctcccgccgt tgctagcgtg gccggcggtt ccggctccgg cggtttctct      480

gcctccttgc attctgagcc accagtctac gcgaacctgt ccaactttaa tccgggggcg      540

ctgagtagcg gaggcggcgc ccctagctat ggggcagctg gactggcctt cccggcacaa      600

ccccaacaac aacagcaacc gccacaccat cttcctcaac aaatgccagt gcaacatcca      660

cgcttacaag ccctcaagga ggaaccccag accgtgcctg agatgcccgg cgaaaccccg      720

ccattgagcc ctattgacat ggaaagtcaa gagagaatta aggcagagcg caagagaatg      780

aggaaccgga tcgcagcatc taagtgccgc aaacggaaat tggagcggat cgctcgcttg      840

gaggagaagg tcaagactct caaggcccag aactccgagc ttgcgagcac agctaatatg      900

ctgcgcgagc aggtggccca gttaaaacaa aaggtcatga accatgtgaa cagcggctgt      960

cagctgatgc ttacgcaaca gctgcaaacc tttggctccg gtgcaacgaa cttcagcctg     1020

ctgaagcagg ccggagatgt tgaggaaaat ccaggtccc                            1059


<210>  16
<211>  993
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  c-Jun codon optimized #10

<400>  16
atgacggcca aaatggagac tacgttctac gatgacgcac tcaacgcgtc cttcctgccc       60

tctgagagtg gaccctatgg ctactccaat ccaaagatcc tgaagcagtc tatgaccctc      120

aacctggcgg acccggtggg ctcccttaag ccgcacttgc gcgccaagaa ctccgacctg      180

ctgacctccc ctgatgtggg cctcctcaag ctcgctagcc ctgaattgga gaggctgatc      240

atccagagct caaatggcca catcaccacc acacctaccc caacccagtt cctgtgccca      300

aaaaacgtga ccgacgagca ggagggcttc gcggagggct tcgtcagagc tctggccgag      360

ctgcactcac agaacacgct cccttccgtg acctccgctg cccagccggt caatggcgct      420

ggaatggtgg ctccggctgt ggcctctgtt gccggcggct ccggctccgg aggcttttca      480

gcttctctgc attctgagcc cccagtgtac gctaacctga gcaacttcaa ccccggggcg      540

ctcagctccg gtggcggtgc cccgagctac ggcgcggctg ggctggcgtt ccccgctcag      600

cctcagcagc aacagcaacc tccccaccac ctgccacagc agatgcctgt gcagcaccca      660

cgcctgcagg ccttgaagga ggaacctcag actgtgccag agatgcccgg cgagacccca      720

cccctgtccc cgattgacat ggagagccag gagcgcatca aggcagagcg caagcgtatg      780

cgcaaccgca tcgcggcctc caagtgccga aagcgcaagc tggagcggat tgctcgcctg      840

gaggagaagg tgaagaccct gaaggcccag aattccgagc tggcctcgac cgccaacatg      900

ctacgagaac aggtcgcgca gctgaaacag aaggtcatga accatgtcaa cagcgggtgc      960

cagctgatgt tgacccagca gcttcagacc ttc                                   993


<210>  17
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R12 VH

<400>  17

Gln Glu Gln Leu Val Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Lys Ala Ser Gly Phe Asp Phe Ser Ala Tyr 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Thr Ile Tyr Pro Ser Ser Gly Lys Thr Tyr Tyr Ala Thr Trp Val 
    50                  55                  60                  


Asn Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Gln Asn Thr Val Asp 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Thr Ala Ala Asp Arg Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Ser Tyr Ala Asp Asp Gly Ala Leu Phe Asn Ile Trp Gly 
            100                 105                 110         


Pro Gly Thr Leu Val Thr Ile Ser Ser 
        115                 120     


<210>  18
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R12 VH CDR1

<400>  18

Ala Tyr Tyr Met Ser 
1               5   


<210>  19
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R12 VH CDR2

<400>  19

Thr Ile Tyr Pro Ser Ser Gly Lys Thr Tyr Tyr Ala Thr Trp Val Asn 
1               5                   10                  15      


Gly 
    


<210>  20
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R12 VH CDR3

<400>  20

Asp Ser Tyr Ala Asp Asp Gly Ala Leu Phe Asn Ile 
1               5                   10          


<210>  21
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R12 VL

<400>  21

Glu Leu Val Leu Thr Gln Ser Pro Ser Val Ser Ala Ala Leu Gly Ser 
1               5                   10                  15      


Pro Ala Lys Ile Thr Cys Thr Leu Ser Ser Ala His Lys Thr Asp Thr 
            20                  25                  30          


Ile Asp Trp Tyr Gln Gln Leu Gln Gly Glu Ala Pro Arg Tyr Leu Met 
        35                  40                  45              


Gln Val Gln Ser Asp Gly Ser Tyr Thr Lys Arg Pro Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Ser Ser Gly Ala Asp Arg Tyr Leu Ile Ile Pro 
65                  70                  75                  80  


Ser Val Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Asp Tyr 
                85                  90                  95      


Ile Gly Gly Tyr Val Phe Gly Gly Gly Thr Gln Leu Thr Val Thr Gly 
            100                 105                 110         


<210>  22
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R12 VL CDR1

<400>  22

Thr Leu Ser Ser Ala His Lys Thr Asp Thr Ile Asp 
1               5                   10          


<210>  23
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R12 VL CDR2

<400>  23

Gly Ser Tyr Thr Lys Arg Pro 
1               5           


<210>  24
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R12 VL CDR3

<400>  24

Gly Ala Asp Tyr Ile Gly Gly Tyr Val 
1               5                   


<210>  25
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  NR4A1 sgRNA 5

<400>  25
gaaguccucg aacuugaagg                                                   20


<210>  26
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  NR4A1 sgRNA 6

<400>  26
accuucaugg acggcuacac                                                   20


<210>  27
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  NR4A2 sgRNA 1

<400>  27
uugggauggu caaagaaggu                                                   20


<210>  28
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  NR4A2 sgRNA 2

<400>  28
cagccaggca cuucugaaau                                                   20


<210>  29
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  NR4A2 sgRNA 3

<400>  29
uccggcgacg cuuguccacu                                                   20


<210>  30
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  NR4A3 sgRNA 4

<400>  30
gcucgaguag cccuccacga                                                   20


<210>  31
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gRNA 4

<400>  31
ggggtcccgt cggccgggtt                                                   20


<210>  32
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gRNA 5

<400>  32
cccgtcggcc gggttcggcg                                                   20


<210>  33
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gRNA 6

<400>  33
ctttaggggt cccgtcggcc                                                   20


<210>  34
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gRNA 7

<400>  34
cagaacttta ggggtcccgt                                                   20


<210>  35
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gRNA 8

<400>  35
actttagggg tcccgtcggc                                                   20


<210>  36
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gRNA 9

<400>  36
agcgagcggg gggctgcccc                                                   20


<210>  37
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gRNA 10

<400>  37
cgcctccgcc gccggagccc                                                   20


<210>  38
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gRNA 11

<400>  38
cccgtcggcc gggttcggcg                                                   20


<210>  39
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S. aureus chimeric frame

<400>  39
taatacgact cactata                                                      17


<210>  40
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gRNA 1

<400>  40
gtcaataccg ccagaatcca                                                   20


<210>  41
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gRNA 2

<400>  41
caataccgcc agaatccatg                                                   20


<210>  42
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gRNA 3

<400>  42
tcaataccgc cagaatccat                                                   20


<210>  43
<211>  598
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NR4A2 Isoform 1

<400>  43

Met Pro Cys Val Gln Ala Gln Tyr Gly Ser Ser Pro Gln Gly Ala Ser 
1               5                   10                  15      


Pro Ala Ser Gln Ser Tyr Ser Tyr His Ser Ser Gly Glu Tyr Ser Ser 
            20                  25                  30          


Asp Phe Leu Thr Pro Glu Phe Val Lys Phe Ser Met Asp Leu Thr Asn 
        35                  40                  45              


Thr Glu Ile Thr Ala Thr Thr Ser Leu Pro Ser Phe Ser Thr Phe Met 
    50                  55                  60                  


Asp Asn Tyr Ser Thr Gly Tyr Asp Val Lys Pro Pro Cys Leu Tyr Gln 
65                  70                  75                  80  


Met Pro Leu Ser Gly Gln Gln Ser Ser Ile Lys Val Glu Asp Ile Gln 
                85                  90                  95      


Met His Asn Tyr Gln Gln His Ser His Leu Pro Pro Gln Ser Glu Glu 
            100                 105                 110         


Met Met Pro His Ser Gly Ser Val Tyr Tyr Lys Pro Ser Ser Pro Pro 
        115                 120                 125             


Thr Pro Thr Thr Pro Gly Phe Gln Val Gln His Ser Pro Met Trp Asp 
    130                 135                 140                 


Asp Pro Gly Ser Leu His Asn Phe His Gln Asn Tyr Val Ala Thr Thr 
145                 150                 155                 160 


His Met Ile Glu Gln Arg Lys Thr Pro Val Ser Arg Leu Ser Leu Phe 
                165                 170                 175     


Ser Phe Lys Gln Ser Pro Pro Gly Thr Pro Val Ser Ser Cys Gln Met 
            180                 185                 190         


Arg Phe Asp Gly Pro Leu His Val Pro Met Asn Pro Glu Pro Ala Gly 
        195                 200                 205             


Ser His His Val Val Asp Gly Gln Thr Phe Ala Val Pro Asn Pro Ile 
    210                 215                 220                 


Arg Lys Pro Ala Ser Met Gly Phe Pro Gly Leu Gln Ile Gly His Ala 
225                 230                 235                 240 


Ser Gln Leu Leu Asp Thr Gln Val Pro Ser Pro Pro Ser Arg Gly Ser 
                245                 250                 255     


Pro Ser Asn Glu Gly Leu Cys Ala Val Cys Gly Asp Asn Ala Ala Cys 
            260                 265                 270         


Gln His Tyr Gly Val Arg Thr Cys Glu Gly Cys Lys Gly Phe Phe Lys 
        275                 280                 285             


Arg Thr Val Gln Lys Asn Ala Lys Tyr Val Cys Leu Ala Asn Lys Asn 
    290                 295                 300                 


Cys Pro Val Asp Lys Arg Arg Arg Asn Arg Cys Gln Tyr Cys Arg Phe 
305                 310                 315                 320 


Gln Lys Cys Leu Ala Val Gly Met Val Lys Glu Val Val Arg Thr Asp 
                325                 330                 335     


Ser Leu Lys Gly Arg Arg Gly Arg Leu Pro Ser Lys Pro Lys Ser Pro 
            340                 345                 350         


Gln Glu Pro Ser Pro Pro Ser Pro Pro Val Ser Leu Ile Ser Ala Leu 
        355                 360                 365             


Val Arg Ala His Val Asp Ser Asn Pro Ala Met Thr Ser Leu Asp Tyr 
    370                 375                 380                 


Ser Arg Phe Gln Ala Asn Pro Asp Tyr Gln Met Ser Gly Asp Asp Thr 
385                 390                 395                 400 


Gln His Ile Gln Gln Phe Tyr Asp Leu Leu Thr Gly Ser Met Glu Ile 
                405                 410                 415     


Ile Arg Gly Trp Ala Glu Lys Ile Pro Gly Phe Ala Asp Leu Pro Lys 
            420                 425                 430         


Ala Asp Gln Asp Leu Leu Phe Glu Ser Ala Phe Leu Glu Leu Phe Val 
        435                 440                 445             


Leu Arg Leu Ala Tyr Arg Ser Asn Pro Val Glu Gly Lys Leu Ile Phe 
    450                 455                 460                 


Cys Asn Gly Val Val Leu His Arg Leu Gln Cys Val Arg Gly Phe Gly 
465                 470                 475                 480 


Glu Trp Ile Asp Ser Ile Val Glu Phe Ser Ser Asn Leu Gln Asn Met 
                485                 490                 495     


Asn Ile Asp Ile Ser Ala Phe Ser Cys Ile Ala Ala Leu Ala Met Val 
            500                 505                 510         


Thr Glu Arg His Gly Leu Lys Glu Pro Lys Arg Val Glu Glu Leu Gln 
        515                 520                 525             


Asn Lys Ile Val Asn Cys Leu Lys Asp His Val Thr Phe Asn Asn Gly 
    530                 535                 540                 


Gly Leu Asn Arg Pro Asn Tyr Leu Ser Lys Leu Leu Gly Lys Leu Pro 
545                 550                 555                 560 


Glu Leu Arg Thr Leu Cys Thr Gln Gly Leu Gln Arg Ile Phe Tyr Leu 
                565                 570                 575     


Lys Leu Glu Asp Leu Val Pro Pro Pro Ala Ile Ile Asp Lys Leu Phe 
            580                 585                 590         


Leu Asp Thr Leu Pro Phe 
        595             


<210>  44
<211>  535
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NR4A2 Isoform 2

<400>  44

Met Asp Asn Tyr Ser Thr Gly Tyr Asp Val Lys Pro Pro Cys Leu Tyr 
1               5                   10                  15      


Gln Met Pro Leu Ser Gly Gln Gln Ser Ser Ile Lys Val Glu Asp Ile 
            20                  25                  30          


Gln Met His Asn Tyr Gln Gln His Ser His Leu Pro Pro Gln Ser Glu 
        35                  40                  45              


Glu Met Met Pro His Ser Gly Ser Val Tyr Tyr Lys Pro Ser Ser Pro 
    50                  55                  60                  


Pro Thr Pro Thr Thr Pro Gly Phe Gln Val Gln His Ser Pro Met Trp 
65                  70                  75                  80  


Asp Asp Pro Gly Ser Leu His Asn Phe His Gln Asn Tyr Val Ala Thr 
                85                  90                  95      


Thr His Met Ile Glu Gln Arg Lys Thr Pro Val Ser Arg Leu Ser Leu 
            100                 105                 110         


Phe Ser Phe Lys Gln Ser Pro Pro Gly Thr Pro Val Ser Ser Cys Gln 
        115                 120                 125             


Met Arg Phe Asp Gly Pro Leu His Val Pro Met Asn Pro Glu Pro Ala 
    130                 135                 140                 


Gly Ser His His Val Val Asp Gly Gln Thr Phe Ala Val Pro Asn Pro 
145                 150                 155                 160 


Ile Arg Lys Pro Ala Ser Met Gly Phe Pro Gly Leu Gln Ile Gly His 
                165                 170                 175     


Ala Ser Gln Leu Leu Asp Thr Gln Val Pro Ser Pro Pro Ser Arg Gly 
            180                 185                 190         


Ser Pro Ser Asn Glu Gly Leu Cys Ala Val Cys Gly Asp Asn Ala Ala 
        195                 200                 205             


Cys Gln His Tyr Gly Val Arg Thr Cys Glu Gly Cys Lys Gly Phe Phe 
    210                 215                 220                 


Lys Arg Thr Val Gln Lys Asn Ala Lys Tyr Val Cys Leu Ala Asn Lys 
225                 230                 235                 240 


Asn Cys Pro Val Asp Lys Arg Arg Arg Asn Arg Cys Gln Tyr Cys Arg 
                245                 250                 255     


Phe Gln Lys Cys Leu Ala Val Gly Met Val Lys Glu Val Val Arg Thr 
            260                 265                 270         


Asp Ser Leu Lys Gly Arg Arg Gly Arg Leu Pro Ser Lys Pro Lys Ser 
        275                 280                 285             


Pro Gln Glu Pro Ser Pro Pro Ser Pro Pro Val Ser Leu Ile Ser Ala 
    290                 295                 300                 


Leu Val Arg Ala His Val Asp Ser Asn Pro Ala Met Thr Ser Leu Asp 
305                 310                 315                 320 


Tyr Ser Arg Phe Gln Ala Asn Pro Asp Tyr Gln Met Ser Gly Asp Asp 
                325                 330                 335     


Thr Gln His Ile Gln Gln Phe Tyr Asp Leu Leu Thr Gly Ser Met Glu 
            340                 345                 350         


Ile Ile Arg Gly Trp Ala Glu Lys Ile Pro Gly Phe Ala Asp Leu Pro 
        355                 360                 365             


Lys Ala Asp Gln Asp Leu Leu Phe Glu Ser Ala Phe Leu Glu Leu Phe 
    370                 375                 380                 


Val Leu Arg Leu Ala Tyr Arg Ser Asn Pro Val Glu Gly Lys Leu Ile 
385                 390                 395                 400 


Phe Cys Asn Gly Val Val Leu His Arg Leu Gln Cys Val Arg Gly Phe 
                405                 410                 415     


Gly Glu Trp Ile Asp Ser Ile Val Glu Phe Ser Ser Asn Leu Gln Asn 
            420                 425                 430         


Met Asn Ile Asp Ile Ser Ala Phe Ser Cys Ile Ala Ala Leu Ala Met 
        435                 440                 445             


Val Thr Glu Arg His Gly Leu Lys Glu Pro Lys Arg Val Glu Glu Leu 
    450                 455                 460                 


Gln Asn Lys Ile Val Asn Cys Leu Lys Asp His Val Thr Phe Asn Asn 
465                 470                 475                 480 


Gly Gly Leu Asn Arg Pro Asn Tyr Leu Ser Lys Leu Leu Gly Lys Leu 
                485                 490                 495     


Pro Glu Leu Arg Thr Leu Cys Thr Gln Gly Leu Gln Arg Ile Phe Tyr 
            500                 505                 510         


Leu Lys Leu Glu Asp Leu Val Pro Pro Pro Ala Ile Ile Asp Lys Leu 
        515                 520                 525             


Phe Leu Asp Thr Leu Pro Phe 
    530                 535 


<210>  45
<211>  598
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NR4A1 Isoform 1

<400>  45

Met Pro Cys Ile Gln Ala Gln Tyr Gly Thr Pro Ala Pro Ser Pro Gly 
1               5                   10                  15      


Pro Arg Asp His Leu Ala Ser Asp Pro Leu Thr Pro Glu Phe Ile Lys 
            20                  25                  30          


Pro Thr Met Asp Leu Ala Ser Pro Glu Ala Ala Pro Ala Ala Pro Thr 
        35                  40                  45              


Ala Leu Pro Ser Phe Ser Thr Phe Met Asp Gly Tyr Thr Gly Glu Phe 
    50                  55                  60                  


Asp Thr Phe Leu Tyr Gln Leu Pro Gly Thr Val Gln Pro Cys Ser Ser 
65                  70                  75                  80  


Ala Ser Ser Ser Ala Ser Ser Thr Ser Ser Ser Ser Ala Thr Ser Pro 
                85                  90                  95      


Ala Ser Ala Ser Phe Lys Phe Glu Asp Phe Gln Val Tyr Gly Cys Tyr 
            100                 105                 110         


Pro Gly Pro Leu Ser Gly Pro Val Asp Glu Ala Leu Ser Ser Ser Gly 
        115                 120                 125             


Ser Asp Tyr Tyr Gly Ser Pro Cys Ser Ala Pro Ser Pro Ser Thr Pro 
    130                 135                 140                 


Ser Phe Gln Pro Pro Gln Leu Ser Pro Trp Asp Gly Ser Phe Gly His 
145                 150                 155                 160 


Phe Ser Pro Ser Gln Thr Tyr Glu Gly Leu Arg Ala Trp Thr Glu Gln 
                165                 170                 175     


Leu Pro Lys Ala Ser Gly Pro Pro Gln Pro Pro Ala Phe Phe Ser Phe 
            180                 185                 190         


Ser Pro Pro Thr Gly Pro Ser Pro Ser Leu Ala Gln Ser Pro Leu Lys 
        195                 200                 205             


Leu Phe Pro Ser Gln Ala Thr His Gln Leu Gly Glu Gly Glu Ser Tyr 
    210                 215                 220                 


Ser Met Pro Thr Ala Phe Pro Gly Leu Ala Pro Thr Ser Pro His Leu 
225                 230                 235                 240 


Glu Gly Ser Gly Ile Leu Asp Thr Pro Val Thr Ser Thr Lys Ala Arg 
                245                 250                 255     


Ser Gly Ala Pro Gly Gly Ser Glu Gly Arg Cys Ala Val Cys Gly Asp 
            260                 265                 270         


Asn Ala Ser Cys Gln His Tyr Gly Val Arg Thr Cys Glu Gly Cys Lys 
        275                 280                 285             


Gly Phe Phe Lys Arg Thr Val Gln Lys Asn Ala Lys Tyr Ile Cys Leu 
    290                 295                 300                 


Ala Asn Lys Asp Cys Pro Val Asp Lys Arg Arg Arg Asn Arg Cys Gln 
305                 310                 315                 320 


Phe Cys Arg Phe Gln Lys Cys Leu Ala Val Gly Met Val Lys Glu Val 
                325                 330                 335     


Val Arg Thr Asp Ser Leu Lys Gly Arg Arg Gly Arg Leu Pro Ser Lys 
            340                 345                 350         


Pro Lys Gln Pro Pro Asp Ala Ser Pro Ala Asn Leu Leu Thr Ser Leu 
        355                 360                 365             


Val Arg Ala His Leu Asp Ser Gly Pro Ser Thr Ala Lys Leu Asp Tyr 
    370                 375                 380                 


Ser Lys Phe Gln Glu Leu Val Leu Pro His Phe Gly Lys Glu Asp Ala 
385                 390                 395                 400 


Gly Asp Val Gln Gln Phe Tyr Asp Leu Leu Ser Gly Ser Leu Glu Val 
                405                 410                 415     


Ile Arg Lys Trp Ala Glu Lys Ile Pro Gly Phe Ala Glu Leu Ser Pro 
            420                 425                 430         


Ala Asp Gln Asp Leu Leu Leu Glu Ser Ala Phe Leu Glu Leu Phe Ile 
        435                 440                 445             


Leu Arg Leu Ala Tyr Arg Ser Lys Pro Gly Glu Gly Lys Leu Ile Phe 
    450                 455                 460                 


Cys Ser Gly Leu Val Leu His Arg Leu Gln Cys Ala Arg Gly Phe Gly 
465                 470                 475                 480 


Asp Trp Ile Asp Ser Ile Leu Ala Phe Ser Arg Ser Leu His Ser Leu 
                485                 490                 495     


Leu Val Asp Val Pro Ala Phe Ala Cys Leu Ser Ala Leu Val Leu Ile 
            500                 505                 510         


Thr Asp Arg His Gly Leu Gln Glu Pro Arg Arg Val Glu Glu Leu Gln 
        515                 520                 525             


Asn Arg Ile Ala Ser Cys Leu Lys Glu His Val Ala Ala Val Ala Gly 
    530                 535                 540                 


Glu Pro Gln Pro Ala Ser Cys Leu Ser Arg Leu Leu Gly Lys Leu Pro 
545                 550                 555                 560 


Glu Leu Arg Thr Leu Cys Thr Gln Gly Leu Gln Arg Ile Phe Tyr Leu 
                565                 570                 575     


Lys Leu Glu Asp Leu Val Pro Pro Pro Pro Ile Ile Asp Lys Ile Phe 
            580                 585                 590         


Met Asp Thr Leu Pro Phe 
        595             


<210>  46
<211>  611
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NR4A1 Isoform 2

<400>  46

Met Trp Leu Ala Lys Ala Cys Trp Ser Ile Gln Ser Glu Met Pro Cys 
1               5                   10                  15      


Ile Gln Ala Gln Tyr Gly Thr Pro Ala Pro Ser Pro Gly Pro Arg Asp 
            20                  25                  30          


His Leu Ala Ser Asp Pro Leu Thr Pro Glu Phe Ile Lys Pro Thr Met 
        35                  40                  45              


Asp Leu Ala Ser Pro Glu Ala Ala Pro Ala Ala Pro Thr Ala Leu Pro 
    50                  55                  60                  


Ser Phe Ser Thr Phe Met Asp Gly Tyr Thr Gly Glu Phe Asp Thr Phe 
65                  70                  75                  80  


Leu Tyr Gln Leu Pro Gly Thr Val Gln Pro Cys Ser Ser Ala Ser Ser 
                85                  90                  95      


Ser Ala Ser Ser Thr Ser Ser Ser Ser Ala Thr Ser Pro Ala Ser Ala 
            100                 105                 110         


Ser Phe Lys Phe Glu Asp Phe Gln Val Tyr Gly Cys Tyr Pro Gly Pro 
        115                 120                 125             


Leu Ser Gly Pro Val Asp Glu Ala Leu Ser Ser Ser Gly Ser Asp Tyr 
    130                 135                 140                 


Tyr Gly Ser Pro Cys Ser Ala Pro Ser Pro Ser Thr Pro Ser Phe Gln 
145                 150                 155                 160 


Pro Pro Gln Leu Ser Pro Trp Asp Gly Ser Phe Gly His Phe Ser Pro 
                165                 170                 175     


Ser Gln Thr Tyr Glu Gly Leu Arg Ala Trp Thr Glu Gln Leu Pro Lys 
            180                 185                 190         


Ala Ser Gly Pro Pro Gln Pro Pro Ala Phe Phe Ser Phe Ser Pro Pro 
        195                 200                 205             


Thr Gly Pro Ser Pro Ser Leu Ala Gln Ser Pro Leu Lys Leu Phe Pro 
    210                 215                 220                 


Ser Gln Ala Thr His Gln Leu Gly Glu Gly Glu Ser Tyr Ser Met Pro 
225                 230                 235                 240 


Thr Ala Phe Pro Gly Leu Ala Pro Thr Ser Pro His Leu Glu Gly Ser 
                245                 250                 255     


Gly Ile Leu Asp Thr Pro Val Thr Ser Thr Lys Ala Arg Ser Gly Ala 
            260                 265                 270         


Pro Gly Gly Ser Glu Gly Arg Cys Ala Val Cys Gly Asp Asn Ala Ser 
        275                 280                 285             


Cys Gln His Tyr Gly Val Arg Thr Cys Glu Gly Cys Lys Gly Phe Phe 
    290                 295                 300                 


Lys Arg Thr Val Gln Lys Asn Ala Lys Tyr Ile Cys Leu Ala Asn Lys 
305                 310                 315                 320 


Asp Cys Pro Val Asp Lys Arg Arg Arg Asn Arg Cys Gln Phe Cys Arg 
                325                 330                 335     


Phe Gln Lys Cys Leu Ala Val Gly Met Val Lys Glu Val Val Arg Thr 
            340                 345                 350         


Asp Ser Leu Lys Gly Arg Arg Gly Arg Leu Pro Ser Lys Pro Lys Gln 
        355                 360                 365             


Pro Pro Asp Ala Ser Pro Ala Asn Leu Leu Thr Ser Leu Val Arg Ala 
    370                 375                 380                 


His Leu Asp Ser Gly Pro Ser Thr Ala Lys Leu Asp Tyr Ser Lys Phe 
385                 390                 395                 400 


Gln Glu Leu Val Leu Pro His Phe Gly Lys Glu Asp Ala Gly Asp Val 
                405                 410                 415     


Gln Gln Phe Tyr Asp Leu Leu Ser Gly Ser Leu Glu Val Ile Arg Lys 
            420                 425                 430         


Trp Ala Glu Lys Ile Pro Gly Phe Ala Glu Leu Ser Pro Ala Asp Gln 
        435                 440                 445             


Asp Leu Leu Leu Glu Ser Ala Phe Leu Glu Leu Phe Ile Leu Arg Leu 
    450                 455                 460                 


Ala Tyr Arg Ser Lys Pro Gly Glu Gly Lys Leu Ile Phe Cys Ser Gly 
465                 470                 475                 480 


Leu Val Leu His Arg Leu Gln Cys Ala Arg Gly Phe Gly Asp Trp Ile 
                485                 490                 495     


Asp Ser Ile Leu Ala Phe Ser Arg Ser Leu His Ser Leu Leu Val Asp 
            500                 505                 510         


Val Pro Ala Phe Ala Cys Leu Ser Ala Leu Val Leu Ile Thr Asp Arg 
        515                 520                 525             


His Gly Leu Gln Glu Pro Arg Arg Val Glu Glu Leu Gln Asn Arg Ile 
    530                 535                 540                 


Ala Ser Cys Leu Lys Glu His Val Ala Ala Val Ala Gly Glu Pro Gln 
545                 550                 555                 560 


Pro Ala Ser Cys Leu Ser Arg Leu Leu Gly Lys Leu Pro Glu Leu Arg 
                565                 570                 575     


Thr Leu Cys Thr Gln Gly Leu Gln Arg Ile Phe Tyr Leu Lys Leu Glu 
            580                 585                 590         


Asp Leu Val Pro Pro Pro Pro Ile Ile Asp Lys Ile Phe Met Asp Thr 
        595                 600                 605             


Leu Pro Phe 
    610     


<210>  47
<211>  325
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NR4A1 Isoform 3

<400>  47

Met Pro Cys Ile Gln Ala Gln Tyr Gly Thr Pro Ala Pro Ser Pro Gly 
1               5                   10                  15      


Pro Arg Asp His Leu Ala Ser Asp Pro Leu Thr Pro Glu Phe Ile Lys 
            20                  25                  30          


Pro Thr Met Asp Leu Ala Ser Pro Glu Ala Ala Pro Ala Ala Pro Thr 
        35                  40                  45              


Ala Leu Pro Ser Phe Ser Thr Phe Met Asp Gly Tyr Thr Gly Glu Phe 
    50                  55                  60                  


Asp Thr Phe Leu Tyr Gln Leu Pro Gly Thr Val Gln Pro Cys Ser Ser 
65                  70                  75                  80  


Ala Ser Ser Ser Ala Ser Ser Thr Ser Ser Ser Ser Ala Thr Ser Pro 
                85                  90                  95      


Ala Ser Ala Ser Phe Lys Phe Glu Asp Phe Gln Val Tyr Gly Cys Tyr 
            100                 105                 110         


Pro Gly Pro Leu Ser Gly Pro Val Asp Glu Ala Leu Ser Ser Ser Gly 
        115                 120                 125             


Ser Asp Tyr Tyr Gly Ser Pro Cys Ser Ala Pro Ser Pro Ser Thr Pro 
    130                 135                 140                 


Ser Phe Gln Pro Pro Gln Leu Ser Pro Trp Asp Gly Ser Phe Gly His 
145                 150                 155                 160 


Phe Ser Pro Ser Gln Thr Tyr Glu Gly Leu Arg Ala Trp Thr Glu Gln 
                165                 170                 175     


Leu Pro Lys Ala Ser Gly Pro Pro Gln Pro Pro Ala Phe Phe Ser Phe 
            180                 185                 190         


Ser Pro Pro Thr Gly Pro Ser Pro Ser Leu Ala Gln Ser Pro Leu Lys 
        195                 200                 205             


Leu Phe Pro Ser Gln Ala Thr His Gln Leu Gly Glu Gly Glu Ser Tyr 
    210                 215                 220                 


Ser Met Pro Thr Ala Phe Pro Gly Leu Ala Pro Thr Ser Pro His Leu 
225                 230                 235                 240 


Glu Gly Ser Gly Ile Leu Asp Thr Pro Val Thr Ser Thr Lys Ala Arg 
                245                 250                 255     


Ser Gly Ala Pro Gly Gly Ser Glu Gly Arg Cys Ala Val Cys Gly Asp 
            260                 265                 270         


Asn Ala Ser Cys Gln His Tyr Gly Val Arg Thr Cys Glu Gly Cys Lys 
        275                 280                 285             


Gly Phe Phe Lys Val Pro Arg Ser Pro Arg Trp Gly Leu Leu Leu Glu 
    290                 295                 300                 


Met Glu Arg Gly Trp Pro His Pro Ile Gly Thr Cys Gly Leu Pro Leu 
305                 310                 315                 320 


Gly Ser Pro Pro Ser 
                325 


<210>  48
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  NR4A3 sgRNA 1

<400>  48
caauauagcc cuuccccucc                                                   20


<210>  49
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  NR4A3 sgRNA 2

<400>  49
aacuggaacc uggaggggaa                                                   20


<210>  50
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  NR4A3 sgRNA 3

<400>  50
uaacuggaac cuggagggga                                                   20


<210>  51

<400>  51
000

<210>  52
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  NR4A3 sgRNA 5

<400>  52
ccgcugcauu ugguacacgc                                                   20


<210>  53
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  NR4A3 sgRNA 6

<400>  53
ugcggcgcag acauacagcu                                                   20


<210>  54
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  NR4A3 sgRNA 7

<400>  54
gcagcggccc uugaucaaag                                                   20


<210>  55
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  NR4A3 sgRNA 8

<400>  55
auacagcucg gaauacacca                                                   20


<210>  56
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  NR4A3 sgRNA 9

<400>  56
ccugcgugua ccaaaugcag                                                   20


<210>  57
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  NR4A3 sgRNA 10

<400>  57
gcggcccuug aucaaagugg                                                   20


<210>  58
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  NR4A3 sgRNA 11

<400>  58
ggacugcuug aaguacaugg                                                   20


<210>  59
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  NR4A3 sgRNA 12

<400>  59
cggguggcuc ucaagcgcgg                                                   20


<210>  60
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  NR4A3 sgRNA 13

<400>  60
gacgacgagc uccugcuggg                                                   20


<210>  61
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  NR4A3 sgRNA 14

<400>  61
gucgggguuc augaucuccg                                                   20


<210>  62
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  NR4A3 sgRNA 15

<400>  62
gagggcuuga aguggaagag                                                   20


<210>  63
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  NR4A3 sgRNA 16

<400>  63
gaugaaggcg guccccacgg                                                   20


<210>  64
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  NR4A3 sgRNA 17

<400>  64
gaagguacug augcugggca                                                   20


<210>  65
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  NR4A3 sgRNA 18

<400>  65
uccuccagcc uccagcccgg                                                   20


<210>  66
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  NR4A3 sgRNA 19

<400>  66
agcaucagua ccuucgugga                                                   20


<210>  67
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  NR4A3 sgRNA 20

<400>  67
cgacuacacc aagcugacca                                                   20


<210>  68
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  NR4A3 sgRNA 21

<400>  68
uggucagcuu gguguagucg                                                   20


<210>  69
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  NR4A3 sgRNA 22

<400>  69
gcuggacccg ccgaugaagg                                                   20


<210>  70
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  NR4A3 sgRNA 23

<400>  70
uugaaguaca uggaggugcu                                                   20


<210>  71
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  NR4A3 sgRNA 24

<400>  71
guacgggugg cucucaagcg                                                   20


<210>  72
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  NR4A3 sgRNA 25

<400>  72
ccgcauaacu ggaaccugga                                                   20


<210>  73
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  NR4A3 sgRNA 26

<400>  73
gggcacgugu gccgugugcg                                                   20


<210>  74
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  NR4A3 sgRNA 27

<400>  74
uacggcgugc gaaccugcga                                                   20


<210>  75
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  NR4A3 sgRNA 28

<400>  75
uggggacugc uugaaguaca                                                   20


<210>  76
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  NR4A3 sgRNA 29

<400>  76
ccuuggcagc acugagauca                                                   20


<210>  77
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  NR4A3 sgRNA 30

<400>  77
ccuugaucaa aguggaggag                                                   20


<210>  78
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  NR4A3 sgRNA 31

<400>  78
ugcauuuggu acacgcagga                                                   20


<210>  79
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  NR4A3 sgRNA 32

<400>  79
ugaucaaagu ggaggagggg                                                   20


<210>  80
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  NR4A3 sgRNA 33

<400>  80
guggggaccg ccuucaucgg                                                   20


<210>  81
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  NR4A3 sgRNA 34

<400>  81
aggagcucgu cgucuggcga                                                   20


<210>  82
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  NR4A3 sgRNA 35

<400>  82
ccaccucggc uacgacccga                                                   20


<210>  83
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  NR4A3 sgRNA 36

<400>  83
gcggcggcga gggcuugaag                                                   20


<210>  84
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  NR4A3 sgRNA 37

<400>  84
cagcaucagu accuucgugg                                                   20


<210>  85
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  NR4A3 sgRNA 38

<400>  85
gccgaugaag gcggucccca                                                   20


<210>  86
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  NR4A3 sgRNA 39

<400>  86
ccgucggguc guagccgagg                                                   20


<210>  87
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  NR4A3 sgRNA 40

<400>  87
cuacggcgug cgaaccugcg                                                   20


<210>  88
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  NR4A3 sgRNA 41

<400>  88
ccauaacgcc cccgccugcg                                                   20


<210>  89
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  NR4A3 sgRNA 42

<400>  89
auaacgcccc cgccugcggg                                                   20


<210>  90
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  NR4A3 sgRNA 43

<400>  90
gccgcauaac uggaaccugg                                                   20


<210>  91
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  NR4A3 sgRNA 44

<400>  91
gaaaucgaca guacugacau                                                   20


<210>  92
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  NR4A3 sgRNA 45

<400>  92
uuucagaagu gucucagugu                                                   20


<210>  93
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  NR4A3 sgRNA 46

<400>  93
gaagugucuc aguguuggaa                                                   20


<210>  94
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  NR4A3 sgRNA 47

<400>  94
aguguuggaa ugguaaaaga                                                   20


<210>  95
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  NR4A3 sgRNA 48

<400>  95
guacagauag ucugaaaggg                                                   20


<210>  96
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  NR4A3 sgRNA 49

<400>  96
guguugaguc uguuaaagcu                                                   20


<210>  97
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  NR4A3 sgRNA 50

<400>  97
gauagucuga aagggaggag                                                   20


<210>  98
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  NR4A3 sgRNA 51

<400>  98
agucuguuaa agcucggaca                                                   20


<210>  99
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  NR4A3 sgRNA 52

<400>  99
guccguacag auagucugaa                                                   20


<210>  100
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NBRE

<400>  100
aaaaggtca                                                                9


<210>  101

<400>  101
000

<210>  102

<400>  102
000

<210>  103

<400>  103
000

<210>  104

<400>  104
000

<210>  105

<400>  105
000

<210>  106
<211>  92
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NR4A1 DBD #1

<400>  106

Ser Glu Gly Arg Cys Ala Val Cys Gly Asp Asn Ala Ser Cys Gln His 
1               5                   10                  15      


Tyr Gly Val Arg Thr Cys Glu Gly Cys Lys Gly Phe Phe Lys Arg Thr 
            20                  25                  30          


Val Gln Lys Asn Ala Lys Tyr Ile Cys Leu Ala Asn Lys Asp Cys Pro 
        35                  40                  45              


Val Asp Lys Arg Arg Arg Asn Arg Cys Gln Phe Cys Arg Phe Gln Lys 
    50                  55                  60                  


Cys Leu Ala Val Gly Met Val Lys Glu Val Val Arg Thr Asp Ser Leu 
65                  70                  75                  80  


Lys Gly Arg Arg Gly Arg Leu Pro Ser Lys Pro Lys 
                85                  90          


<210>  107
<211>  93
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NR4A1 DBD #2

<400>  107

Ser Glu Gly Arg Cys Ala Val Cys Gly Asp Asn Ala Ser Cys Gln His 
1               5                   10                  15      


Tyr Gly Val Arg Thr Cys Glu Gly Cys Lys Gly Phe Phe Lys Arg Thr 
            20                  25                  30          


Val Gln Lys Asn Ala Lys Tyr Ile Cys Leu Ala Asn Lys Asp Cys Pro 
        35                  40                  45              


Val Asp Lys Arg Arg Arg Asn Arg Cys Gln Phe Cys Arg Phe Gln Lys 
    50                  55                  60                  


Cys Leu Ala Val Gly Met Val Lys Glu Val Val Arg Thr Asp Ser Leu 
65                  70                  75                  80  


Lys Gly Arg Arg Gly Arg Leu Pro Ser Lys Pro Lys Gln 
                85                  90              


<210>  108
<211>  92
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NR4A2 DBD #1

<400>  108

Asn Glu Gly Leu Cys Ala Val Cys Gly Asp Asn Ala Ala Cys Gln His 
1               5                   10                  15      


Tyr Gly Val Arg Thr Cys Glu Gly Cys Lys Gly Phe Phe Lys Arg Thr 
            20                  25                  30          


Val Gln Lys Asn Ala Lys Tyr Val Cys Leu Ala Asn Lys Asn Cys Pro 
        35                  40                  45              


Val Asp Lys Arg Arg Arg Asn Arg Cys Gln Tyr Cys Arg Phe Gln Lys 
    50                  55                  60                  


Cys Leu Ala Val Gly Met Val Lys Glu Val Val Arg Thr Asp Ser Leu 
65                  70                  75                  80  


Lys Gly Arg Arg Gly Arg Leu Pro Ser Lys Pro Lys 
                85                  90          


<210>  109
<211>  93
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NR4A2 DBD #2

<400>  109

Asn Glu Gly Leu Cys Ala Val Cys Gly Asp Asn Ala Ala Cys Gln His 
1               5                   10                  15      


Tyr Gly Val Arg Thr Cys Glu Gly Cys Lys Gly Phe Phe Lys Arg Thr 
            20                  25                  30          


Val Gln Lys Asn Ala Lys Tyr Val Cys Leu Ala Asn Lys Asn Cys Pro 
        35                  40                  45              


Val Asp Lys Arg Arg Arg Asn Arg Cys Gln Tyr Cys Arg Phe Gln Lys 
    50                  55                  60                  


Cys Leu Ala Val Gly Met Val Lys Glu Val Val Arg Thr Asp Ser Leu 
65                  70                  75                  80  


Lys Gly Arg Arg Gly Arg Leu Pro Ser Lys Pro Lys Ser 
                85                  90              


<210>  110
<211>  92
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NR4A3 DBD #1

<400>  110

Gly Glu Gly Thr Cys Ala Val Cys Gly Asp Asn Ala Ala Cys Gln His 
1               5                   10                  15      


Tyr Gly Val Arg Thr Cys Glu Gly Cys Lys Gly Phe Phe Lys Arg Thr 
            20                  25                  30          


Val Gln Lys Asn Ala Lys Tyr Val Cys Leu Ala Asn Lys Asn Cys Pro 
        35                  40                  45              


Val Asp Lys Arg Arg Arg Asn Arg Cys Gln Tyr Cys Arg Phe Gln Lys 
    50                  55                  60                  


Cys Leu Ser Val Gly Met Val Lys Glu Val Val Arg Thr Asp Ser Leu 
65                  70                  75                  80  


Lys Gly Arg Arg Gly Arg Leu Pro Ser Lys Pro Lys 
                85                  90          


<210>  111
<211>  93
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NR4A3 DBD #2

<400>  111

Gly Glu Gly Thr Cys Ala Val Cys Gly Asp Asn Ala Ala Cys Gln His 
1               5                   10                  15      


Tyr Gly Val Arg Thr Cys Glu Gly Cys Lys Gly Phe Phe Lys Arg Thr 
            20                  25                  30          


Val Gln Lys Asn Ala Lys Tyr Val Cys Leu Ala Asn Lys Asn Cys Pro 
        35                  40                  45              


Val Asp Lys Arg Arg Arg Asn Arg Cys Gln Tyr Cys Arg Phe Gln Lys 
    50                  55                  60                  


Cys Leu Ser Val Gly Met Val Lys Glu Val Val Arg Thr Asp Ser Leu 
65                  70                  75                  80  


Lys Gly Arg Arg Gly Arg Leu Pro Ser Lys Pro Lys Ser 
                85                  90              


<210>  112
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DBD with NBRE-binding TAL

<400>  112

Met Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn His Gly Gly 
1               5                   10                  15      


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Cys Gln Ala 
            20                  25                  30          


His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly 
        35                  40                  45              


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Cys Gln 
    50                  55                  60                  


Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Gly 
65                  70                  75                  80  


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Cys 
                85                  90                  95      


Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn 
            100                 105                 110         


Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
        115                 120                 125             


Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser 
    130                 135                 140                 


Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
145                 150                 155                 160 


Val Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala 
                165                 170                 175     


Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
            180                 185                 190         


Pro Val Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile 
        195                 200                 205             


Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
    210                 215                 220                 


Leu Pro Val Cys Gln Ala His Gly 
225                 230         


<210>  113
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DBD with NurRE-binding TAL #1

<400>  113

Met Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn His Gly Gly 
1               5                   10                  15      


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Cys Gln Ala 
            20                  25                  30          


His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly 
        35                  40                  45              


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Cys Gln 
    50                  55                  60                  


Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Gly 
65                  70                  75                  80  


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Cys 
                85                  90                  95      


Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn 
            100                 105                 110         


Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
        115                 120                 125             


Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser 
    130                 135                 140                 


Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
145                 150                 155                 160 


Val Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala 
                165                 170                 175     


Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
            180                 185                 190         


Pro Val Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile 
        195                 200                 205             


Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
    210                 215                 220                 


Leu Pro Val Cys Gln Ala His Gly 
225                 230         


<210>  114
<211>  231
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DBD with NurRE-binding TAL #2

<400>  114

Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys 
1               5                   10                  15      


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Cys Gln Ala His 
            20                  25                  30          


Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly 
        35                  40                  45              


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Cys Gln Ala 
    50                  55                  60                  


His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly 
65                  70                  75                  80  


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Cys Gln 
                85                  90                  95      


Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Gly 
            100                 105                 110         


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Cys 
        115                 120                 125             


Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn 
    130                 135                 140                 


His Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
145                 150                 155                 160 


Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser 
                165                 170                 175     


His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
            180                 185                 190         


Val Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala 
        195                 200                 205             


Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
    210                 215                 220                 


Pro Val Cys Gln Ala His Gly 
225                 230     


<210>  115
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ZFP binding sequence #1

<400>  115
aaaggtcaa                                                                9


<210>  116

<400>  116
000

<210>  117
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ZFP binding sequence #3

<400>  117
gatatt                                                                   6


<210>  118
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ZFP binding sequence #4

<400>  118
gccaat                                                                   6


<210>  119
<211>  92
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DBD with ZFP #1

<400>  119

Leu Glu Pro Gly Glu Lys Pro Tyr Lys Cys Pro Glu Cys Gly Lys Ser 
1               5                   10                  15      


Phe Ser Gln Ser Gly Asn Leu Thr Glu His Gln Arg Thr His Thr Gly 
            20                  25                  30          


Glu Lys Pro Tyr Lys Cys Pro Glu Cys Gly Lys Ser Phe Ser Thr Ser 
        35                  40                  45              


Gly His Leu Val Arg His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr 
    50                  55                  60                  


Lys Cys Pro Glu Cys Gly Lys Ser Phe Ser Gln Arg Ala Asn Leu Arg 
65                  70                  75                  80  


Ala His Gln Arg Thr His Thr Gly Lys Lys Thr Ser 
                85                  90          


<210>  120
<211>  64
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DBD with ZFP #2

<400>  120

Leu Glu Pro Gly Glu Lys Pro Tyr Lys Cys Pro Glu Cys Gly Lys Ser 
1               5                   10                  15      


Phe Ser His Lys Asn Ala Leu Gln Asn His Gln Arg Thr His Thr Gly 
            20                  25                  30          


Glu Lys Pro Tyr Lys Cys Pro Glu Cys Gly Lys Ser Phe Ser Thr Ser 
        35                  40                  45              


Gly Asn Leu Val Arg His Gln Arg Thr His Thr Gly Lys Lys Thr Ser 
    50                  55                  60                  


<210>  121
<211>  64
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DBD with ZFP #3

<400>  121

Leu Glu Pro Gly Glu Lys Pro Tyr Lys Cys Pro Glu Cys Gly Lys Ser 
1               5                   10                  15      


Phe Ser Asp Cys Arg Asp Leu Ala Arg His Gln Arg Thr His Thr Gly 
            20                  25                  30          


Glu Lys Pro Tyr Lys Cys Pro Glu Cys Gly Lys Ser Phe Ser Thr Thr 
        35                  40                  45              


Gly Asn Leu Thr Val His Gln Arg Thr His Thr Gly Lys Lys Thr Ser 
    50                  55                  60                  


<210>  122
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NR4A LBD #1

<400>  122

Pro Leu Gln Gln Glu Pro Ser Gln Pro Ser Pro Pro Ser Pro Pro Ile 
1               5                   10                  15      


Cys Met Met Asn Ala Leu Val Arg Ala Leu Thr Asp Ser Thr Pro Arg 
            20                  25                  30          


Asp Leu Asp Tyr Ser Arg Tyr Cys Pro Thr Asp Gln Ala Ala Ala Gly 
        35                  40                  45              


Thr Asp Ala Glu His Val Gln Gln Phe Tyr Asn Leu Leu Thr Ala Ser 
    50                  55                  60                  


Ile Asp Val Ser Arg Ser Trp Ala Glu Lys Ile Pro Gly Phe Thr Asp 
65                  70                  75                  80  


Leu Pro Lys Glu Asp Gln Thr Leu Leu Ile Glu Ser Ala Phe Leu Glu 
                85                  90                  95      


Leu Phe Val Leu Arg Leu Ser Ile Arg Ser Asn Thr Ala Glu Asp Lys 
            100                 105                 110         


Phe Val Phe Cys Asn Gly Leu Val Leu His Arg Leu Gln Cys Leu Arg 
        115                 120                 125             


Gly Phe Gly Glu Trp Leu Asp Ser Ile Lys Asp Phe Ser Leu Asn Leu 
    130                 135                 140                 


Gln Ser Leu Asn Leu Asp Ile Gln Ala Leu Ala Cys Leu Ser Ala Leu 
145                 150                 155                 160 


Ser Met Ile Thr Glu Arg His Gly Leu Lys Glu Pro Lys Arg Val Glu 
                165                 170                 175     


Glu Leu Cys Asn Lys Ile Thr Ser Ser Leu Lys Asp His Gln Ser Lys 
            180                 185                 190         


Gly Gln Ala Leu Glu Pro Thr Glu Ser Lys Val Leu Gly Ala Leu Val 
        195                 200                 205             


Glu Leu Arg Lys Ile Cys Thr Leu Gly Leu Gln Arg Ile Phe Tyr Leu 
    210                 215                 220                 


Lys Leu Glu Asp Leu Val Ser Pro Pro Ser Ile Ile Asp Lys Leu Phe 
225                 230                 235                 240 


Leu Asp Thr Leu Pro Phe 
                245     


<210>  123
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NR4A LBD #2

<400>  123

Ser Pro Leu Gln Gln Glu Pro Ser Gln Pro Ser Pro Pro Ser Pro Pro 
1               5                   10                  15      


Ile Cys Met Met Asn Ala Leu Val Arg Ala Leu Thr Asp Ser Thr Pro 
            20                  25                  30          


Arg Asp Leu Asp Tyr Ser Arg Tyr Cys Pro Thr Asp Gln Ala Ala Ala 
        35                  40                  45              


Gly Thr Asp Ala Glu His Val Gln Gln Phe Tyr Asn Leu Leu Thr Ala 
    50                  55                  60                  


Ser Ile Asp Val Ser Arg Ser Trp Ala Glu Lys Ile Pro Gly Phe Thr 
65                  70                  75                  80  


Asp Leu Pro Lys Glu Asp Gln Thr Leu Leu Ile Glu Ser Ala Phe Leu 
                85                  90                  95      


Glu Leu Phe Val Leu Arg Leu Ser Ile Arg Ser Asn Thr Ala Glu Asp 
            100                 105                 110         


Lys Phe Val Phe Cys Asn Gly Leu Val Leu His Arg Leu Gln Cys Leu 
        115                 120                 125             


Arg Gly Phe Gly Glu Trp Leu Asp Ser Ile Lys Asp Phe Ser Leu Asn 
    130                 135                 140                 


Leu Gln Ser Leu Asn Leu Asp Ile Gln Ala Leu Ala Cys Leu Ser Ala 
145                 150                 155                 160 


Leu Ser Met Ile Thr Glu Arg His Gly Leu Lys Glu Pro Lys Arg Val 
                165                 170                 175     


Glu Glu Leu Cys Asn Lys Ile Thr Ser Ser Leu Lys Asp His Gln Ser 
            180                 185                 190         


Lys Gly Gln Ala Leu Glu Pro Thr Glu Ser Lys Val Leu Gly Ala Leu 
        195                 200                 205             


Val Glu Leu Arg Lys Ile Cys Thr Leu Gly Leu Gln Arg Ile Phe Tyr 
    210                 215                 220                 


Leu Lys Leu Glu Asp Leu Val Ser Pro Pro Ser Ile Ile Asp Lys Leu 
225                 230                 235                 240 


Phe Leu Asp Thr Leu Pro Phe 
                245         


