                         SEQUENCE LISTING

<110>  The Regents of the University of California
       WANG, Lei
       LI, Shanshan
 
<120>  PROTEINS HAVING UNNATURAL AMINO ACIDS AND METHODS OF USE

<130>  048536-712001WO

<140>  PCT/US22/31925
<141>  2022-06-02

<150>  63/238,357
<151>  2021-08-30

<150>  63/196,006
<151>  2021-06-02

<160>  59    

<170>  PatentIn version 3.5

<210>  1
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  1

Met Leu Leu Leu Leu Leu Leu Pro Leu Leu Trp Gly Arg Glu Arg Val 
1               5                   10                  15      


Glu Gly Gln Lys Ser Asn Arg Lys Asp Tyr Ser Leu Thr Met Gln Ser 
            20                  25                  30          


Ser Val Thr Val Gln Glu Gly Met Cys Val His Val Arg Cys Ser Phe 
        35                  40                  45              


Ser Tyr Pro Val Asp Ser Gln Thr Asp Ser Asp Pro Val His Gly Tyr 
    50                  55                  60                  


Trp Phe Arg Ala Gly Asn Asp Ile Ser Trp Lys Ala Pro Val Ala Thr 
65                  70                  75                  80  


Asn Asn Pro Ala Trp Ala Val Gln Glu Glu Thr Arg Asp Arg Phe His 
                85                  90                  95      


Leu Leu Gly Asp Pro Gln Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp 
            100                 105                 110         


Ala Arg Met Ser Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly 
        115                 120                 125             


Asn Ile Lys Trp Asn Tyr Lys Tyr Asp Gln Leu Ser Val Asn Val Thr 
    130                 135                 140                 


Ala Leu Thr His Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser 
145                 150                 155                 160 


Gly Cys Phe Gln Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln 
                165                 170                 175     


Gly Thr Pro Pro Met Ile Ser Trp Met Gly Thr Ser Val Ser Pro Leu 
            180                 185                 190         


His Pro Ser Thr Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro 
        195                 200                 205             


Gln His His Gly Thr Ser Leu Thr Cys Gln Val Thr Leu Pro Gly Ala 
    210                 215                 220                 


Gly Val Thr Thr Asn Arg Thr Ile Gln Leu Asn Val Ser Tyr Pro Pro 
225                 230                 235                 240 


Gln Asn Leu Thr Val Thr Val Phe Gln Gly Glu Gly Thr Ala Ser Thr 
                245                 250                 255     


Ala Leu Gly Asn Ser Ser Ser Leu Ser Val Leu Glu Gly Gln Ser Leu 
            260                 265                 270         


Arg Leu Val Cys Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Trp 
        275                 280                 285             


Thr Trp Arg Ser Leu Thr Leu Tyr Pro Ser Gln Pro Ser Asn Pro Leu 
    290                 295                 300                 


Val Leu Glu Leu Gln Val His Leu Gly Asp Glu Gly Glu Phe Thr Cys 
305                 310                 315                 320 


Arg Ala Gln Asn Ser Leu Gly Ser Gln His Val Ser Leu Asn Leu Ser 
                325                 330                 335     


Leu Gln Gln Glu Tyr Thr Gly Lys Met Arg Pro Val Ser Gly Val Leu 
            340                 345                 350         


Leu Gly Ala Val Gly Gly Ala Gly Ala Thr Ala Leu Val Phe Leu Ser 
        355                 360                 365             


Phe Cys Val Ile Phe Ile Val Val Arg Ser Cys Arg Lys Lys Ser Ala 
    370                 375                 380                 


Arg Pro Ala Ala Asp Val Gly Asp Ile Gly Met Lys Asp Ala Asn Thr 
385                 390                 395                 400 


Ile Arg Gly Ser Ala Ser Gln Gly Asn Leu Thr Glu Ser Trp Ala Asp 
                405                 410                 415     


Asp Asn Pro Arg His His Gly Leu Ala Ala His Ser Ser Gly Glu Glu 
            420                 425                 430         


Arg Glu Ile Gln Tyr Ala Pro Leu Ser Phe His Lys Gly Glu Pro Gln 
        435                 440                 445             


Asp Leu Ser Gly Gln Glu Ala Thr Asn Asn Glu Tyr Ser Glu Ile Lys 
    450                 455                 460                 


Ile Pro Lys 
465         


<210>  2
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  2

Gln Lys Ser Asn Arg Lys Asp Tyr Ser Leu Thr Met Gln Ser Ser Val 
1               5                   10                  15      


Thr Val Gln Glu Gly Met Cys Val His Val Arg Cys Ser Phe Ser Tyr 
            20                  25                  30          


Pro Val Asp Ser Gln Thr Asp Ser Asp Pro Val His Gly Tyr Trp Phe 
        35                  40                  45              


Arg Ala Gly Asn Asp Ile Ser Trp Lys Ala Pro Val Ala Thr Asn Asn 
    50                  55                  60                  


Pro Ala Trp Ala Val Gln Glu Glu Thr Arg Asp Arg Phe His Leu Leu 
65                  70                  75                  80  


Gly Asp Pro Gln Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg 
                85                  90                  95      


Met Ser Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Asn Ile 
            100                 105                 110         


Lys Trp Asn Tyr Lys Tyr Asp Gln Leu Ser Val Asn Val Thr Ala Leu 
        115                 120                 125             


Thr His 
    130 


<210>  3
<211>  137
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  3

Met Gln Lys Ser Asn Arg Lys Asp Tyr Ser Leu Thr Met Gln Ser Ser 
1               5                   10                  15      


Val Thr Val Gln Glu Gly Met Ser Val His Val Arg Cys Ser Phe Ser 
            20                  25                  30          


Tyr Pro Val Asp Ser Gln Thr Asp Ser Asp Pro Val His Gly Tyr Trp 
        35                  40                  45              


Phe Arg Ala Gly Asn Asp Ile Ser Trp Lys Ala Pro Val Ala Thr Asn 
    50                  55                  60                  


Asn Pro Ala Trp Ala Val Gln Glu Glu Thr Arg Asp Arg Phe His Leu 
65                  70                  75                  80  


Leu Gly Asp Pro Gln Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala 
                85                  90                  95      


Arg Met Ser Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Asn 
            100                 105                 110         


Ile Lys Trp Asn Tyr Lys Tyr Asp Gln Leu Ser Val Asn Val Thr Ala 
        115                 120                 125             


Leu Thr His His His His His His His 
    130                 135         


<210>  4
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  4

Gln Lys Ser Asn Arg Lys Asp Tyr Ser Leu Thr Met Gln Ser Ser Val 
1               5                   10                  15      


Thr Val Gln Glu Gly Met Ser Val His Val Arg Cys Ser Phe Ser Tyr 
            20                  25                  30          


Pro Val Asp Ser Gln Thr Asp Ser Asp Pro Val His Gly Tyr Trp Phe 
        35                  40                  45              


Arg Ala Gly Asn Asp Ile Ser Trp Lys Ala Pro Val Ala Thr Asn Asn 
    50                  55                  60                  


Pro Ala Trp Ala Val Gln Glu Glu Thr Arg Asp Arg Phe His Leu Leu 
65                  70                  75                  80  


Gly Asp Pro Gln Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg 
                85                  90                  95      


Met Ser Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Asn Ile 
            100                 105                 110         


Lys Trp Asn Tyr Lys Tyr Asp Gln Leu Ser Val Asn Val Thr Ala Leu 
        115                 120                 125             


Thr His 
    130 


<210>  5
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  5

Met Asp Lys Lys Pro Leu Asn Thr Leu Ile Ser Ala Thr Gly Leu Trp 
1               5                   10                  15      


Met Ser Arg Thr Gly Thr Ile His Lys Ile Lys His His Glu Val Ser 
            20                  25                  30          


Arg Ser Lys Ile Tyr Ile Glu Met Ala Cys Gly Asp His Leu Val Val 
        35                  40                  45              


Asn Asn Ser Arg Ser Ser Arg Thr Ala Arg Ala Leu Arg His His Lys 
    50                  55                  60                  


Tyr Arg Lys Thr Cys Lys Arg Cys Arg Val Ser Asp Glu Asp Leu Asn 
65                  70                  75                  80  


Lys Phe Leu Thr Lys Ala Asn Glu Asp Gln Thr Ser Val Lys Val Lys 
                85                  90                  95      


Val Val Ser Ala Pro Thr Arg Thr Lys Lys Ala Met Pro Lys Ser Val 
            100                 105                 110         


Ala Arg Ala Pro Lys Pro Leu Glu Asn Thr Glu Ala Ala Gln Ala Gln 
        115                 120                 125             


Pro Ser Gly Ser Lys Phe Ser Pro Ala Ile Pro Val Ser Thr Gln Glu 
    130                 135                 140                 


Ser Val Ser Val Pro Ala Ser Val Ser Thr Ser Ile Ser Ser Ile Ser 
145                 150                 155                 160 


Thr Gly Ala Thr Ala Ser Ala Leu Val Lys Gly Asn Thr Asn Pro Ile 
                165                 170                 175     


Thr Ser Met Ser Ala Pro Val Gln Ala Ser Ala Pro Ala Leu Thr Lys 
            180                 185                 190         


Ser Gln Thr Asp Arg Leu Glu Val Leu Leu Asn Pro Lys Asp Glu Ile 
        195                 200                 205             


Ser Leu Asn Ser Gly Lys Pro Phe Arg Glu Leu Glu Ser Glu Leu Leu 
    210                 215                 220                 


Ser Arg Arg Lys Lys Asp Leu Gln Gln Ile Tyr Ala Glu Glu Arg Glu 
225                 230                 235                 240 


Asn Tyr Leu Gly Lys Leu Glu Arg Glu Ile Thr Arg Phe Phe Val Asp 
                245                 250                 255     


Arg Gly Phe Leu Glu Ile Lys Ser Pro Ile Leu Ile Pro Leu Glu Tyr 
            260                 265                 270         


Ile Glu Arg Met Gly Ile Asp Asn Asp Thr Glu Leu Ser Lys Gln Ile 
        275                 280                 285             


Phe Arg Val Asp Lys Asn Phe Cys Leu Arg Pro Met Leu Ala Pro Asn 
    290                 295                 300                 


Leu Tyr Asn Tyr Leu Arg Lys Leu Asp Arg Ala Leu Pro Asp Pro Ile 
305                 310                 315                 320 


Lys Ile Phe Glu Ile Gly Pro Cys Tyr Arg Lys Glu Ser Asp Gly Lys 
                325                 330                 335     


Glu His Leu Glu Glu Phe Thr Met Leu Asn Phe Cys Gln Met Gly Ser 
            340                 345                 350         


Gly Cys Thr Arg Glu Asn Leu Glu Ser Ile Ile Thr Asp Phe Leu Asn 
        355                 360                 365             


His Leu Gly Ile Asp Phe Lys Ile Val Gly Asp Ser Cys Met Val Tyr 
    370                 375                 380                 


Gly Asp Thr Leu Asp Val Met His Gly Asp Leu Glu Leu Ser Ser Ala 
385                 390                 395                 400 


Val Val Gly Pro Ile Pro Leu Asp Arg Glu Trp Gly Ile Asp Lys Pro 
                405                 410                 415     


Trp Ile Gly Ala Gly Phe Gly Leu Glu Arg Leu Leu Lys Val Lys His 
            420                 425                 430         


Asp Phe Lys Asn Ile Lys Arg Ala Ala Arg Ser Glu Ser Tyr Tyr Asn 
        435                 440                 445             


Gly Ile Ser Thr Asn Leu 
    450                 


<210>  6
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  6

Met Asp Lys Lys Pro Leu Asn Thr Leu Ile Ser Ala Thr Gly Leu Trp 
1               5                   10                  15      


Met Ser Arg Thr Gly Thr Ile His Lys Ile Lys His His Glu Val Ser 
            20                  25                  30          


Arg Ser Lys Ile Tyr Ile Glu Met Ala Cys Gly Asp His Leu Val Val 
        35                  40                  45              


Asn Asn Ser Arg Ser Ser Arg Thr Ala Arg Ala Leu Arg His His Lys 
    50                  55                  60                  


Tyr Arg Lys Thr Cys Lys Arg Cys Arg Val Ser Asp Glu Asp Leu Asn 
65                  70                  75                  80  


Lys Phe Leu Thr Lys Ala Asn Glu Asp Gln Thr Ser Val Lys Val Lys 
                85                  90                  95      


Val Val Ser Ala Pro Thr Arg Thr Lys Lys Ala Met Pro Lys Ser Val 
            100                 105                 110         


Ala Arg Ala Pro Lys Pro Leu Glu Asn Thr Glu Ala Ala Gln Ala Gln 
        115                 120                 125             


Pro Ser Gly Ser Lys Phe Ser Pro Ala Ile Pro Val Ser Thr Gln Glu 
    130                 135                 140                 


Ser Val Ser Val Pro Ala Ser Val Ser Thr Ser Ile Ser Ser Ile Ser 
145                 150                 155                 160 


Thr Gly Ala Thr Ala Ser Ala Leu Val Lys Gly Asn Thr Asn Pro Ile 
                165                 170                 175     


Thr Ser Met Ser Ala Pro Val Gln Ala Ser Ala Pro Ala Leu Thr Lys 
            180                 185                 190         


Ser Gln Thr Asp Arg Leu Glu Val Leu Leu Asn Pro Lys Asp Glu Ile 
        195                 200                 205             


Ser Leu Asn Ser Gly Lys Pro Phe Arg Glu Leu Glu Ser Glu Leu Leu 
    210                 215                 220                 


Ser Arg Arg Lys Lys Asp Leu Gln Gln Ile Tyr Ala Glu Glu Arg Glu 
225                 230                 235                 240 


Asn Tyr Leu Gly Lys Leu Glu Arg Glu Ile Thr Arg Phe Phe Val Asp 
                245                 250                 255     


Arg Gly Phe Leu Glu Ile Lys Ser Pro Ile Leu Ile Pro Leu Glu Tyr 
            260                 265                 270         


Ile Glu Arg Met Gly Ile Asp Asn Asp Thr Glu Leu Ser Lys Gln Ile 
        275                 280                 285             


Phe Arg Val Asp Lys Asn Phe Cys Leu Arg Pro Met Leu Ala Pro Asn 
    290                 295                 300                 


Leu Leu Asn Tyr Ala Arg Lys Leu Asp Arg Ala Leu Pro Asp Pro Ile 
305                 310                 315                 320 


Lys Ile Phe Glu Ile Gly Pro Cys Tyr Arg Lys Glu Ser Asp Gly Lys 
                325                 330                 335     


Glu His Leu Glu Glu Phe Thr Met Leu Ala Phe Met Gln Met Gly Ser 
            340                 345                 350         


Gly Cys Thr Arg Glu Asn Leu Glu Ser Ile Ile Thr Asp Phe Leu Asn 
        355                 360                 365             


His Leu Gly Ile Asp Phe Lys Ile Val Gly Asp Ser Cys Met Val Tyr 
    370                 375                 380                 


Gly Asp Thr Leu Asp Val Met His Gly Asp Leu Glu Leu Ser Ser Ala 
385                 390                 395                 400 


Val Val Gly Pro Ile Pro Leu Asp Arg Glu Trp Gly Ile Asp Lys Pro 
                405                 410                 415     


Thr Ile Gly Ala Gly Phe Gly Leu Glu Arg Leu Leu Lys Val Lys His 
            420                 425                 430         


Asp Phe Lys Asn Ile Lys Arg Ala Ala Arg Ser Glu Ser Tyr Tyr Asn 
        435                 440                 445             


Gly Ile Ser Thr Asn Leu 
    450                 


<210>  7
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  7

Met Thr Val Lys Tyr Thr Asp Ala Gln Ile Gln Arg Leu Arg Glu Tyr 
1               5                   10                  15      


Gly Asn Gly Thr Tyr Glu Gln Lys Val Phe Glu Asp Leu Ala Ser Arg 
            20                  25                  30          


Asp Ala Ala Phe Ser Lys Glu Met Ser Val Ala Ser Thr Asp Asn Glu 
        35                  40                  45              


Lys Lys Ile Lys Gly Met Ile Ala Asn Pro Ser Arg His Gly Leu Thr 
    50                  55                  60                  


Gln Leu Met Asn Asp Ile Ala Asp Ala Leu Val Ala Glu Gly Phe Ile 
65                  70                  75                  80  


Glu Val Arg Thr Pro Ile Phe Ile Ser Lys Asp Ala Leu Ala Arg Met 
                85                  90                  95      


Thr Ile Thr Glu Asp Lys Pro Leu Phe Lys Gln Val Phe Trp Ile Asp 
            100                 105                 110         


Glu Lys Arg Ala Leu Arg Pro Met Leu Ala Pro Asn Leu Tyr Ser Val 
        115                 120                 125             


Met Arg Asp Leu Arg Asp His Thr Asp Gly Pro Val Lys Ile Phe Glu 
    130                 135                 140                 


Met Gly Ser Cys Phe Arg Lys Glu Ser His Ser Gly Met His Leu Glu 
145                 150                 155                 160 


Glu Phe Thr Met Leu Asn Leu Val Asp Met Gly Pro Arg Gly Asp Ala 
                165                 170                 175     


Thr Glu Val Leu Lys Asn Tyr Ile Ser Val Val Met Lys Ala Ala Gly 
            180                 185                 190         


Leu Pro Asp Tyr Asp Leu Val Gln Glu Glu Ser Asp Val Tyr Lys Glu 
        195                 200                 205             


Thr Ile Asp Val Glu Ile Asn Gly Gln Glu Val Cys Ser Ala Ala Val 
    210                 215                 220                 


Gly Pro His Tyr Leu Asp Ala Ala His Asp Val His Glu Pro Trp Ser 
225                 230                 235                 240 


Gly Ala Gly Phe Gly Leu Glu Arg Leu Leu Thr Ile Arg Glu Lys Tyr 
                245                 250                 255     


Ser Thr Val Lys Lys Gly Gly Ala Ser Ile Ser Tyr Leu Asn Gly Ala 
            260                 265                 270         


Lys Ile Asn 
        275 


<210>  8
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  8

Met Thr Val Lys Tyr Thr Asp Ala Gln Ile Gln Arg Leu Arg Glu Tyr 
1               5                   10                  15      


Gly Asn Gly Thr Tyr Glu Gln Lys Val Phe Glu Asp Leu Ala Ser Arg 
            20                  25                  30          


Asp Ala Ala Phe Ser Lys Glu Met Ser Val Ala Ser Thr Asp Asn Glu 
        35                  40                  45              


Lys Lys Ile Lys Gly Met Ile Ala Asn Pro Ser Arg His Gly Leu Thr 
    50                  55                  60                  


Gln Leu Met Asn Asp Ile Ala Asp Ala Leu Val Ala Glu Gly Phe Ile 
65                  70                  75                  80  


Glu Val Arg Thr Pro Ile Phe Ile Ser Lys Asp Ala Leu Ala Arg Met 
                85                  90                  95      


Thr Ile Thr Glu Asp Lys Pro Leu Phe Lys Gln Val Phe Trp Ile Asp 
            100                 105                 110         


Glu Lys Arg Ala Leu Arg Pro Met Leu Ala Pro Asn Leu Leu Ser Val 
        115                 120                 125             


Ala Arg Asp Leu Arg Asp His Thr Asp Gly Pro Val Lys Ile Phe Glu 
    130                 135                 140                 


Met Gly Ser Cys Phe Arg Lys Glu Ser His Ser Gly Met His Leu Glu 
145                 150                 155                 160 


Glu Phe Thr Met Leu Ala Leu Met Asp Met Gly Pro Arg Gly Asp Ala 
                165                 170                 175     


Thr Glu Val Leu Lys Asn Tyr Ile Ser Val Val Met Lys Ala Ala Gly 
            180                 185                 190         


Leu Pro Asp Tyr Asp Leu Val Gln Glu Glu Ser Asp Val Tyr Lys Glu 
        195                 200                 205             


Thr Ile Asp Val Glu Ile Asn Gly Gln Glu Val Cys Ser Ala Ala Val 
    210                 215                 220                 


Gly Pro His Tyr Leu Asp Ala Ala His Asp Val His Glu Pro Thr Ser 
225                 230                 235                 240 


Gly Ala Gly Phe Gly Leu Glu Arg Leu Leu Thr Ile Arg Glu Lys Tyr 
                245                 250                 255     


Ser Thr Val Lys Lys Gly Gly Ala Ser Ile Ser Tyr Leu Asn Gly Ala 
            260                 265                 270         


Lys Ile Asn 
        275 


<210>  9
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  9
atgcagaaaa gtaatcgtaa agattatagc ctgaccatgc agagcagcgt gaccgttcag       60

gaaggtatgt ctgttcatgt gcgttgcagt tttagctatc cggttgatag ccagaccgat      120

agcgatccgg tgcatggcta ttggtttcgc gccggtaatg atattagttg gaaagccccg      180

gttgccacca ataatccggc atgggcagtg caggaagaaa cccgcgatcg ctttcatctg      240

ctgggtgacc cgcagaccaa aaattgtacc ctgagtattc gcgatgcacg tatgagtgat      300

gcaggccgct atttctttcg catggaaaaa ggtaatatca aatggaatta caagtacgat      360

cagctgagtg ttaatgttac cgccttgacc caccatcacc atcaccatca c               411


<210>  10
<211>  35
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (17)..(21)
<223>  n is a, c, g, or u

<400>  10
gucguguaga auagcannnn nagaucggaa gagcg                                  35


<210>  11
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  11
ucguguag                                                                 8


<210>  12
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (47)..(54)
<223>  n is a, c, g, or t

<400>  12
acacgacgct cttccgaaat gatacggcga ccaccgagat ctacacnnnn nnnnacactc       60

t                                                                       61


<210>  13
<211>  70
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (51)..(58)
<223>  n is a, c, g, or t

<400>  13
ttccctacac gacgctcttc cgatctcaag cagaagacgg catacgagat nnnnnnnngt       60

gactggagtt                                                              70


<210>  14
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  14
cagacgtgtg ctcttccgat ct                                                22


<210>  15
<211>  137
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  15

Met Gln Lys Ser Asn Arg Lys Asp Tyr Ser Leu Thr Met Gln Ser Ser 
1               5                   10                  15      


Val Thr Val Gln Glu Gly Met Ser Val His Val Arg Cys Ser Phe Ser 
            20                  25                  30          


Tyr Pro Val Asp Ser Gln Thr Asp Ser Asp Pro Val His Gly Tyr Trp 
        35                  40                  45              


Phe Arg Ala Gly Asn Asp Ile Ser Trp Lys Ala Pro Val Ala Thr Asn 
    50                  55                  60                  


Asn Pro Ala Trp Ala Val Gln Glu Glu Thr Arg Asp Arg Phe His Leu 
65                  70                  75                  80  


Leu Gly Asp Pro Gln Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala 
                85                  90                  95      


Arg Met Ser Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Asn 
            100                 105                 110         


Ile Lys Trp Asn Tyr Lys Tyr Asp Gln Leu Ser Val Asn Val Thr Ala 
        115                 120                 125             


Leu Thr His His His His His His His 
    130                 135         


<210>  16
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<400>  16

Met Xaa Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val 
1               5                   10                  15      


Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly Glu 
            20                  25                  30          


Gly Glu Gly Asp Ala Thr Asn Gly Lys Leu Thr Leu Lys Phe Ile Cys 
        35                  40                  45              


Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu 
    50                  55                  60                  


Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Arg 
65                  70                  75                  80  


His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg 
                85                  90                  95      


Thr Ile Ser Phe Lys Asp Asp Gly Thr Tyr Lys Thr Arg Ala Glu Val 
            100                 105                 110         


Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile 
        115                 120                 125             


Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn 
    130                 135                 140                 


Phe Asn Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly 
145                 150                 155                 160 


Ile Lys Ala Asn Phe Lys Ile Arg His Asn Val Glu Asp Gly Ser Val 
                165                 170                 175     


Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro 
            180                 185                 190         


Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Val Leu Ser 
        195                 200                 205             


Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val 
    210                 215                 220                 


Thr Ala Ala Gly Ile Thr His Gly Met Asp Glu Leu Tyr Lys Gly Ser 
225                 230                 235                 240 


His His His His His His 
                245     


<210>  17
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa can be any naturally occurring amino acid

<400>  17

Ile Leu His Leu Pro Asn Leu Asn Xaa Glu 
1               5                   10  


<210>  18
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  18
acatatgcag tagagtaatc gtaaagatta tag                                    33


<210>  19
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  19
atatctcctt cttaaagtta aac                                               23


<210>  20
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  20
aagtaatcgt taggattata gcctgac                                           27


<210>  21
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  21
ttctgcatat gtatatctcc                                                   20


<210>  22
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  22
tattagttgg taggccccgg ttgc                                              24


<210>  23
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  23
tcattaccgg cgcgaaac                                                     18


<210>  24
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  24
cccgcagacc tagaattgta ccc                                               23


<210>  25
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  25
tcacccagca gatgaaag                                                     18


<210>  26
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  26
tcgcatggaa tagggtaata tcaaatgg                                          28


<210>  27
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  27
aagaaatagc ggcctgca                                                     18


<210>  28
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  28
ggaaaaaggt tagatcaaat ggaattac                                          28


<210>  29
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  29
atgcgaaaga aatagcgg                                                     18


<210>  30
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  30
aaaaggtaat tagaaatgga attacaagta c                                      31


<210>  31
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  31
tccatgcgaa agaaatag                                                     18


<210>  32
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  32
aggtaatatc tagtggaatt acaagtac                                          28


<210>  33
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  33
ttttccatgc gaaagaaata g                                                 21


<210>  34
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  34
atggaattac tagtacgatc agc                                               23


<210>  35
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  35
ttgatattac ctttttccat g                                                 21


<210>  36
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  36
acatatgcag ggtagtaatc gtaaagatta tag                                    33


<210>  37
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  37
aagtaatcgt ggtgattata gcctgacc                                          28


<210>  38
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  38
tattagttgg ggtgccccgg ttgcc                                             25


<210>  39
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  39
cccgcagacc ggtaattgta ccc                                               23


<210>  40
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  40
tcgcatggaa ggtggtaata tcaaatggaa ttacaag                                37


<210>  41
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  41
aggtaatatc ggttggaatt acaagtacga tc                                     32


<210>  42
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  42
atggaattac ggttacgatc agctgagtgt taatg                                  35


<210>  43
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  43
aacaggagga attactagta tggataaaaa gcctttg                                37


<210>  44
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  44
gatgatgatg atgatggtcg acttacaggt tagtagaa                               38


<210>  45
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  45
taacaggagg aattactagt atgaccgtga agtac                                  35


<210>  46
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  46
tgatgatgat gatggtcgac ttaattgatt ttggcacca                              39


<210>  47
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  47
ctagcatagc ggggttcgac gccccggtct ctcgccaaat tcgaaaagcc tgc              53


<210>  48
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  48
gttttagaga cccgctggtc gccggaccgt cccccaatgc ggggcgcatc t                51


<210>  49
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  49
caggtttggc gccagc                                                       16


<210>  50
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  50
gctggcgcca aacctgttga gcgtggctcg tgacctgcg                              39


<210>  51
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  51
cagcatggtg aactcc                                                       16


<210>  52
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  52
ggagttcacc atgctggctc tgatggatat gggtccgc                               38


<210>  53
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  53
cggctcatgc acgtc                                                        15


<210>  54
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  54
cgtgcatgag ccgacaagcg gtgctggttt tg                                     32


<210>  55
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  55
aaaacctagc cagcggggtt cgacg                                             25


<210>  56
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  56
agagacccgc tggtcgcc                                                     18


<210>  57
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  57
ccaccgcaaa tgcttctagg cggactatga cttagttgcg ttacaccctt tct              53


<210>  58
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  58
catcctggcc tcgctgtcca ccttccagca gatgtggatc agc                         43


<210>  59
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  59
ggatcctagc aaagctgttg aagaagatga ctttgtggtg gggttctg                    48


