                         SEQUENCE LISTING

<110>  THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY
       Weiner, David
       Bhojnagarwala, Pratik
       Gary, Ebony
 
<120>  SYNTHETIC DNA VACCINE IMMUNOGENIC IMPROVEMENTS

<130>  206193-0082-00WO

<150>  US 63/196,486
<151>  2021-06-03

<160>  63    

<170>  PatentIn version 3.5

<210>  1
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1
atgccctacc tgatcgactt cggcctg                                           27


<210>  2
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2

Met Pro Tyr Leu Ile Asp Phe Gly Leu 
1               5                   


<210>  3
<211>  99
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  3
ctgccaggac aggagatcga caaggccgat tcttacatgc cctacctgat cgacttcggc       60

ctgagctcca agagcccata ctctagcgtg aagaacccc                              99


<210>  4
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  4

Leu Pro Gly Gln Glu Ile Asp Lys Ala Asp Ser Tyr Met Pro Tyr Leu 
1               5                   10                  15      


Ile Asp Phe Gly Leu Ser Ser Lys Ser Pro Tyr Ser Ser Val Lys Asn 
            20                  25                  30          


Pro 
    


<210>  5
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  5
ggcgctgtgc agaacgaggt gacc                                              24


<210>  6
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  6

Gly Ala Val Gln Asn Glu Val Thr Leu 
1               5                   


<210>  7
<211>  99
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  7
accctgcacg gacccacacc tctgctgtac agactgggcg ctgtgcagaa cgaggtgacc       60

ctgacacacc ctatcaccaa gtacatcatg gcctgcatg                              99


<210>  8
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  8

Thr Leu His Gly Pro Thr Pro Leu Leu Tyr Arg Leu Gly Ala Val Gln 
1               5                   10                  15      


Asn Glu Val Thr Leu Thr His Pro Ile Thr Lys Tyr Ile Met Ala Cys 
            20                  25                  30          


Met 
    


<210>  9
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  9
agaggcccag gaagagcttt cgtgacaatc                                        30


<210>  10
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  10

Arg Gly Pro Gly Arg Ala Phe Val Thr Ile 
1               5                   10  


<210>  11
<211>  99
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  11
cctaacaaca acaccagaaa gtccatccgg atcaggagag gcccaggaag agctttcgtg       60

acaatcggca agatcggaaa catgaggcag gctcactgt                              99


<210>  12
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  12

Pro Asn Asn Asn Thr Arg Lys Ser Ile Arg Ile Arg Arg Gly Pro Gly 
1               5                   10                  15      


Arg Ala Phe Val Thr Ile Gly Lys Ile Gly Asn Met Arg Gln Ala His 
            20                  25                  30          


Cys 
    


<210>  13
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  13
cgcggcccag gaagggcttt tgtgaccatt                                        30


<210>  14
<211>  99
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  14
aacaacaaca ccaggaagag aatccggatc cagcgcggcc caggaagggc ttttgtgacc       60

attggcaaga ttggcaacat gaggcaggcc cactgcaac                              99


<210>  15
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  15

Asn Asn Asn Thr Arg Lys Arg Ile Arg Ile Gln Arg Gly Pro Gly Arg 
1               5                   10                  15      


Ala Phe Val Thr Ile Gly Lys Ile Gly Asn Met Arg Gln Ala His Cys 
            20                  25                  30          


Asn 
    


<210>  16
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  16
acagtgtacg gattctgtct gctg                                              24


<210>  17
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  17

Thr Val Tyr Gly Phe Cys Leu Leu 
1               5               


<210>  18
<211>  99
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  18
gaggctagca ccgtggtgct ggtgggagct aggggaacag tgtacggatt ctgtctgctg       60

tccaacgacg tgtttagaat cgccgaggat atctctgtg                              99


<210>  19
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  19

Glu Ala Ser Thr Val Val Leu Val Gly Ala Arg Gly Thr Val Tyr Gly 
1               5                   10                  15      


Phe Cys Leu Leu Ser Asn Asp Val Phe Arg Ile Ala Glu Asp Ile Ser 
            20                  25                  30          


Val 
    


<210>  20
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  20
gcttccaacg agaacatgga cgccatg                                           27


<210>  21
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  21

Ala Ser Asn Glu Asn Met Asp Ala Met 
1               5                   


<210>  22
<211>  99
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  22
cccagaggca agctgtccac ccggggagtg cagatcgctt ccaacgagaa catggacgcc       60

atggagtcct ctacactgga gctgcgctct aggtactgg                              99


<210>  23
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  23

Pro Arg Gly Lys Leu Ser Thr Arg Gly Val Gln Ile Ala Ser Asn Glu 
1               5                   10                  15      


Asn Met Asp Ala Met Glu Ser Ser Thr Leu Glu Leu Arg Ser Arg Tyr 
            20                  25                  30          


Trp 
    


<210>  24
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  24
gctatgcaga tgctgaagga gaccatc                                           27


<210>  25
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  25

Ala Met Gln Met Leu Lys Glu Thr Ile 
1               5                   


<210>  26
<211>  99
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  26
aacaccatgc tgaacacagt gggcggacac caggccgcta tgcagatgct gaaggagacc       60

atcaacgagg aggccgctga gtgggataga ctgcaccca                              99


<210>  27
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  27

Asn Thr Met Leu Asn Thr Val Gly Gly His Gln Ala Ala Met Gln Met 
1               5                   10                  15      


Leu Lys Glu Thr Ile Asn Glu Glu Ala Ala Glu Trp Asp Arg Leu His 
            20                  25                  30          


Pro 
    


<210>  28
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  28
gtgtggctga gcgtgatctg gatg                                              24


<210>  29
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  29

Val Trp Leu Ser Val Ile Trp Met 
1               5               


<210>  30
<211>  99
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  30
tccttcgtgc agtggtttgt gggcctgtct cccacagtgt ggctgagcgt gatctggatg       60

atgtggtact ggggaccttc cgtgtactct atcctgagc                              99


<210>  31
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  31

Ser Phe Val Gln Trp Phe Val Gly Leu Ser Pro Thr Val Trp Leu Ser 
1               5                   10                  15      


Val Ile Trp Met Met Trp Tyr Trp Gly Pro Ser Val Tyr Ser Ile Leu 
            20                  25                  30          


Ser 
    


<210>  32
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  32
tccccatctt acgtgtacca ccagttc                                           27


<210>  33
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  33

Ser Pro Ser Tyr Val Tyr His Gln Phe 
1               5                   


<210>  34
<211>  99
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  34
gtgctggtgg agctgtggcc tcgggtgacc taccactccc catcttacgt gtaccaccag       60

ttcgagcggc gcgctaagta caagagggag cccgtgagc                              99


<210>  35
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  35

Val Leu Val Glu Leu Trp Pro Arg Val Thr Tyr His Ser Pro Ser Tyr 
1               5                   10                  15      


Val Tyr His Gln Phe Glu Arg Arg Ala Lys Tyr Lys Arg Glu Pro Val 
            20                  25                  30          


Ser 
    


<210>  36
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  36
tctagcatcg agttcgctcg cctg                                              24


<210>  37
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  37

Ser Ser Ile Glu Phe Ala Arg Leu 
1               5               


<210>  38
<211>  99
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  38
ccttccgcta acgcctccgt ggagaggatc aagaccacat ctagcatcga gttcgctcgc       60

ctgcagttta catacaacca catccagagg cacgtgaac                              99


<210>  39
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  39

Pro Ser Ala Asn Ala Ser Val Glu Arg Ile Lys Thr Thr Ser Ser Ile 
1               5                   10                  15      


Glu Phe Ala Arg Leu Gln Phe Thr Tyr Asn His Ile Gln Arg His Val 
            20                  25                  30          


Asn 
    


<210>  40
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  40
tcctacatcg gatctatcaa caacatc                                           27


<210>  41
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  41

Ser Tyr Ile Gly Ser Ile Asn Asn Ile 
1               5                   


<210>  42
<211>  99
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  42
gaggagtacg ctctgggcat cgtgggagtg ctggagtcct acatcggatc tatcaacaac       60

atcaccaagc agtccgcttg cgtggccatg tctaagctg                              99


<210>  43
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  43

Glu Glu Tyr Ala Leu Gly Ile Val Gly Val Leu Glu Ser Tyr Ile Gly 
1               5                   10                  15      


Ser Ile Asn Asn Ile Thr Lys Gln Ser Ala Cys Val Ala Met Ser Lys 
            20                  25                  30          


Leu 
    


<210>  44
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  44
gccaagtttg tggccgcttg gacactgaag gccgctgcc                              39


<210>  45
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  45

Ala Lys Phe Val Ala Ala Trp Thr Leu Lys Ala Ala Ala 
1               5                   10              


<210>  46
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  46
aggggcagga agaggagatc c                                                 21


<210>  47
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  47
aggggaagaa agcggcgcag c                                                 21


<210>  48
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  48
aggggcagga agcggcgcag c                                                 21


<210>  49
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  49
cgcggaagga agaggagatc t                                                 21


<210>  50
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  50
agaggccgga agcggcgcag c                                                 21


<210>  51
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  51
agaggccgga agaggagaag c                                                 21


<210>  52
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  52
cgcggaagga agcggcgcag c                                                 21


<210>  53
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  53
agaggccgga aaaggagaag c                                                 21


<210>  54
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  54
cgcggcagga agaggagaag c                                                 21


<210>  55
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  55
agaggccgga aacggcgctc c                                                 21


<210>  56
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  56
cgcggcagga aaaggagatc t                                                 21


<210>  57
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  57

Arg Gly Arg Lys Arg Arg Ser 
1               5           


<210>  58
<211>  1362
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  58
atgctgccag gacaggagat cgacaaggcc gattcttaca tgccctacct gatcgacttc       60

ggcctgagct ccaagagccc atactctagc gtgaagaacc ccaggggcag gaagaggaga      120

tccaccctgc acggacccac acctctgctg tacagactgg gcgctgtgca gaacgaggtg      180

accctgacac accctatcac caagtacatc atggcctgca tgaggggaag aaagcggcgc      240

agccctaaca acaacaccag aaagtccatc cggatcagga gaggcccagg aagagctttc      300

gtgacaatcg gcaagatcgg aaacatgagg caggctcact gtaggggcag gaagcggcgc      360

agcaacaaca acaccaggaa gagaatccgg atccagcgcg gcccaggaag ggcttttgtg      420

accattggca agattggcaa catgaggcag gcccactgca accgcggaag gaagaggaga      480

tctgaggcta gcaccgtggt gctggtggga gctaggggaa cagtgtacgg attctgtctg      540

ctgtccaacg acgtgtttag aatcgccgag gatatctctg tgagaggccg gaagcggcgc      600

agccccagag gcaagctgtc cacccgggga gtgcagatcg cttccaacga gaacatggac      660

gccatggagt cctctacact ggagctgcgc tctaggtact ggagaggccg gaagaggaga      720

agcaacacca tgctgaacac agtgggcgga caccaggccg ctatgcagat gctgaaggag      780

accatcaacg aggaggccgc tgagtgggat agactgcacc cacgcggaag gaagcggcgc      840

agctccttcg tgcagtggtt tgtgggcctg tctcccacag tgtggctgag cgtgatctgg      900

atgatgtggt actggggacc ttccgtgtac tctatcctga gcagaggccg gaaaaggaga      960

agcgtgctgg tggagctgtg gcctcgggtg acctaccact ccccatctta cgtgtaccac     1020

cagttcgagc ggcgcgctaa gtacaagagg gagcccgtga gccgcggcag gaagaggaga     1080

agcccttccg ctaacgcctc cgtggagagg atcaagacca catctagcat cgagttcgct     1140

cgcctgcagt ttacatacaa ccacatccag aggcacgtga acagaggccg gaaacggcgc     1200

tccgaggagt acgctctggg catcgtggga gtgctggagt cctacatcgg atctatcaac     1260

aacatcacca agcagtccgc ttgcgtggcc atgtctaagc tgcgcggcag gaaaaggaga     1320

tctgccaagt ttgtggccgc ttggacactg aaggccgctg cc                        1362


<210>  59
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  59

Met Leu Pro Gly Gln Glu Ile Asp Lys Ala Asp Ser Tyr Met Pro Tyr 
1               5                   10                  15      


Leu Ile Asp Phe Gly Leu Ser Ser Lys Ser Pro Tyr Ser Ser Val Lys 
            20                  25                  30          


Asn Pro Arg Gly Arg Lys Arg Arg Ser Thr Leu His Gly Pro Thr Pro 
        35                  40                  45              


Leu Leu Tyr Arg Leu Gly Ala Val Gln Asn Glu Val Thr Leu Thr His 
    50                  55                  60                  


Pro Ile Thr Lys Tyr Ile Met Ala Cys Met Arg Gly Arg Lys Arg Arg 
65                  70                  75                  80  


Ser Pro Asn Asn Asn Thr Arg Lys Ser Ile Arg Ile Arg Arg Gly Pro 
                85                  90                  95      


Gly Arg Ala Phe Val Thr Ile Gly Lys Ile Gly Asn Met Arg Gln Ala 
            100                 105                 110         


His Cys Arg Gly Arg Lys Arg Arg Ser Asn Asn Asn Thr Arg Lys Arg 
        115                 120                 125             


Ile Arg Ile Gln Arg Gly Pro Gly Arg Ala Phe Val Thr Ile Gly Lys 
    130                 135                 140                 


Ile Gly Asn Met Arg Gln Ala His Cys Asn Arg Gly Arg Lys Arg Arg 
145                 150                 155                 160 


Ser Glu Ala Ser Thr Val Val Leu Val Gly Ala Arg Gly Thr Val Tyr 
                165                 170                 175     


Gly Phe Cys Leu Leu Ser Asn Asp Val Phe Arg Ile Ala Glu Asp Ile 
            180                 185                 190         


Ser Val Arg Gly Arg Lys Arg Arg Ser Pro Arg Gly Lys Leu Ser Thr 
        195                 200                 205             


Arg Gly Val Gln Ile Ala Ser Asn Glu Asn Met Asp Ala Met Glu Ser 
    210                 215                 220                 


Ser Thr Leu Glu Leu Arg Ser Arg Tyr Trp Arg Gly Arg Lys Arg Arg 
225                 230                 235                 240 


Ser Asn Thr Met Leu Asn Thr Val Gly Gly His Gln Ala Ala Met Gln 
                245                 250                 255     


Met Leu Lys Glu Thr Ile Asn Glu Glu Ala Ala Glu Trp Asp Arg Leu 
            260                 265                 270         


His Pro Arg Gly Arg Lys Arg Arg Ser Ser Phe Val Gln Trp Phe Val 
        275                 280                 285             


Gly Leu Ser Pro Thr Val Trp Leu Ser Val Ile Trp Met Met Trp Tyr 
    290                 295                 300                 


Trp Gly Pro Ser Val Tyr Ser Ile Leu Ser Arg Gly Arg Lys Arg Arg 
305                 310                 315                 320 


Ser Val Leu Val Glu Leu Trp Pro Arg Val Thr Tyr His Ser Pro Ser 
                325                 330                 335     


Tyr Val Tyr His Gln Phe Glu Arg Arg Ala Lys Tyr Lys Arg Glu Pro 
            340                 345                 350         


Val Ser Arg Gly Arg Lys Arg Arg Ser Pro Ser Ala Asn Ala Ser Val 
        355                 360                 365             


Glu Arg Ile Lys Thr Thr Ser Ser Ile Glu Phe Ala Arg Leu Gln Phe 
    370                 375                 380                 


Thr Tyr Asn His Ile Gln Arg His Val Asn Arg Gly Arg Lys Arg Arg 
385                 390                 395                 400 


Ser Glu Glu Tyr Ala Leu Gly Ile Val Gly Val Leu Glu Ser Tyr Ile 
                405                 410                 415     


Gly Ser Ile Asn Asn Ile Thr Lys Gln Ser Ala Cys Val Ala Met Ser 
            420                 425                 430         


Lys Leu Arg Gly Arg Lys Arg Arg Ser Ala Lys Phe Val Ala Ala Trp 
        435                 440                 445             


Thr Leu Lys Ala Ala Ala 
    450                 


<210>  60
<211>  1302
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  60
atgctgccag gacaggagat cgacaaggcc gattcttaca tgccctacct gatcgacttc       60

ggcctgagct ccaagagccc atactctagc gtgaagaacc ccaggggcag gaagaggaga      120

tccaccctgc acggacccac acctctgctg tacagactgg gcgctgtgca gaacgaggtg      180

accctgacac accctatcac caagtacatc atggcctgca tgaggggaag aaagcggcgc      240

agccctaaca acaacaccag aaagtccatc cggatcagga gaggcccagg aagagctttc      300

gtgacaatcg gcaagatcgg aaacatgagg caggctcact gtaggggcag gaagcggcgc      360

agcaacaaca acaccaggaa gagaatccgg atccagcgcg gcccaggaag ggcttttgtg      420

accattggca agattggcaa catgaggcag gcccactgca accgcggaag gaagaggaga      480

tctgaggcta gcaccgtggt gctggtggga gctaggggaa cagtgtacgg attctgtctg      540

ctgtccaacg acgtgtttag aatcgccgag gatatctctg tgagaggccg gaagcggcgc      600

agccccagag gcaagctgtc cacccgggga gtgcagatcg cttccaacga gaacatggac      660

gccatggagt cctctacact ggagctgcgc tctaggtact ggagaggccg gaagaggaga      720

agcaacacca tgctgaacac agtgggcgga caccaggccg ctatgcagat gctgaaggag      780

accatcaacg aggaggccgc tgagtgggat agactgcacc cacgcggaag gaagcggcgc      840

agctccttcg tgcagtggtt tgtgggcctg tctcccacag tgtggctgag cgtgatctgg      900

atgatgtggt actggggacc ttccgtgtac tctatcctga gcagaggccg gaaaaggaga      960

agcgtgctgg tggagctgtg gcctcgggtg acctaccact ccccatctta cgtgtaccac     1020

cagttcgagc ggcgcgctaa gtacaagagg gagcccgtga gccgcggcag gaagaggaga     1080

agcccttccg ctaacgcctc cgtggagagg atcaagacca catctagcat cgagttcgct     1140

cgcctgcagt ttacatacaa ccacatccag aggcacgtga acagaggccg gaaacggcgc     1200

tccgaggagt acgctctggg catcgtggga gtgctggagt cctacatcgg atctatcaac     1260

aacatcacca agcagtccgc ttgcgtggcc atgtctaagc tg                        1302


<210>  61
<211>  434
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  61

Met Leu Pro Gly Gln Glu Ile Asp Lys Ala Asp Ser Tyr Met Pro Tyr 
1               5                   10                  15      


Leu Ile Asp Phe Gly Leu Ser Ser Lys Ser Pro Tyr Ser Ser Val Lys 
            20                  25                  30          


Asn Pro Arg Gly Arg Lys Arg Arg Ser Thr Leu His Gly Pro Thr Pro 
        35                  40                  45              


Leu Leu Tyr Arg Leu Gly Ala Val Gln Asn Glu Val Thr Leu Thr His 
    50                  55                  60                  


Pro Ile Thr Lys Tyr Ile Met Ala Cys Met Arg Gly Arg Lys Arg Arg 
65                  70                  75                  80  


Ser Pro Asn Asn Asn Thr Arg Lys Ser Ile Arg Ile Arg Arg Gly Pro 
                85                  90                  95      


Gly Arg Ala Phe Val Thr Ile Gly Lys Ile Gly Asn Met Arg Gln Ala 
            100                 105                 110         


His Cys Arg Gly Arg Lys Arg Arg Ser Asn Asn Asn Thr Arg Lys Arg 
        115                 120                 125             


Ile Arg Ile Gln Arg Gly Pro Gly Arg Ala Phe Val Thr Ile Gly Lys 
    130                 135                 140                 


Ile Gly Asn Met Arg Gln Ala His Cys Asn Arg Gly Arg Lys Arg Arg 
145                 150                 155                 160 


Ser Glu Ala Ser Thr Val Val Leu Val Gly Ala Arg Gly Thr Val Tyr 
                165                 170                 175     


Gly Phe Cys Leu Leu Ser Asn Asp Val Phe Arg Ile Ala Glu Asp Ile 
            180                 185                 190         


Ser Val Arg Gly Arg Lys Arg Arg Ser Pro Arg Gly Lys Leu Ser Thr 
        195                 200                 205             


Arg Gly Val Gln Ile Ala Ser Asn Glu Asn Met Asp Ala Met Glu Ser 
    210                 215                 220                 


Ser Thr Leu Glu Leu Arg Ser Arg Tyr Trp Arg Gly Arg Lys Arg Arg 
225                 230                 235                 240 


Ser Asn Thr Met Leu Asn Thr Val Gly Gly His Gln Ala Ala Met Gln 
                245                 250                 255     


Met Leu Lys Glu Thr Ile Asn Glu Glu Ala Ala Glu Trp Asp Arg Leu 
            260                 265                 270         


His Pro Arg Gly Arg Lys Arg Arg Ser Ser Phe Val Gln Trp Phe Val 
        275                 280                 285             


Gly Leu Ser Pro Thr Val Trp Leu Ser Val Ile Trp Met Met Trp Tyr 
    290                 295                 300                 


Trp Gly Pro Ser Val Tyr Ser Ile Leu Ser Arg Gly Arg Lys Arg Arg 
305                 310                 315                 320 


Ser Val Leu Val Glu Leu Trp Pro Arg Val Thr Tyr His Ser Pro Ser 
                325                 330                 335     


Tyr Val Tyr His Gln Phe Glu Arg Arg Ala Lys Tyr Lys Arg Glu Pro 
            340                 345                 350         


Val Ser Arg Gly Arg Lys Arg Arg Ser Pro Ser Ala Asn Ala Ser Val 
        355                 360                 365             


Glu Arg Ile Lys Thr Thr Ser Ser Ile Glu Phe Ala Arg Leu Gln Phe 
    370                 375                 380                 


Thr Tyr Asn His Ile Gln Arg His Val Asn Arg Gly Arg Lys Arg Arg 
385                 390                 395                 400 


Ser Glu Glu Tyr Ala Leu Gly Ile Val Gly Val Leu Glu Ser Tyr Ile 
                405                 410                 415     


Gly Ser Ile Asn Asn Ile Thr Lys Gln Ser Ala Cys Val Ala Met Ser 
            420                 425                 430         


Lys Leu 
        


<210>  62
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  62
ccctacctga tcgacttcgg cctg                                              24


<210>  63
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  63

Pro Tyr Leu Ile Asp Phe Gly Leu 
1               5               


