                         SEQUENCE LISTING

<110>  HOWARD, JOHN
       FAKE, GINA
 
<120>  ORAL ADMINISTRATION OF CORONAVIRUS SPIKE PROTEIN FOR ALTERING CYTOKINE LEVELS AND PROVIDING PASSIVE IMMUNITY TO NEWBORN PIGS 

<130>  P13625US01

<150>  US 63/202,264 
<151>  2021-06-03

<160>  25    

<170>  PatentIn version 3.5

<210>  1
<211>  2238
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  1
atggcgaaca agcacctgag ccttagcctc ttcctcgtgc tcctgggcct ctccgcctcc       60

ctcgcctccg gcgtcacaag gtgctcggct aacaccaact tccgcaggtt cttctccaag      120

ttcaacgtgc aggctcccgc cgtggtggtg ctcggcggct acctgccaat cggcgagaac      180

cagggcgtga attcaacgtg gtactgcgcg ggccagcacc ccacggcctc gggcgtccac      240

ggcatcttcg tgagccacat ccgcggcggc cacggcttcg agatcggcat ctcgcaggag      300

cccttcgacc catcgggcta ccagctctac ctgcacaagg ccacgaacgg caacacgaac      360

gctaccgcca ggctgaggat ctgccagttc ccctccatca agaccctggg cccaaccgcg      420

aacaacgacg tgaccacggg caggaactgc ctgttcaaca aggccatccc ggcgcacatg      480

tccgagcaca gcgtcgtggg catcacgtgg gacaacgacc gcgtcaccgt gttcagcgac      540

aagatctact acttctactt caagaacgac tggtccaggg tcgccaccaa gtgctacaac      600

agcggcggct gcgcgatgca gtatgtgtac gagccgacct actacatgct gaacgtgacg      660

tcggcgggcg aggacggcat cagctaccag ccctgcacgg ccaactgcat cggctacgcc      720

gcgaacgtgt tcgccacgga gcccaacggc cacatcccag agggcttctc cttcaacaac      780

tggttcctcc tgtccaacga cagcaccctg gtccacggca aggtcgtgag caaccagccg      840

ctcctggtga actgcctcct ggcgatcccc aagatctacg gcctcggcca gttcttctcc      900

ttcaaccaga cgatcgacgg cgtctgcaac ggcgcggccg tgcagagggc tcccgaggcg      960

ctgaggttca acatcaacga cacctccgtc atcctggcgg agggcagcat cgtgctccac     1020

acggccctgg gcacgaactt ctccttcgtg tgcagcaact ccagcaaccc ccacctcgcc     1080

acgttcgcca tccccctggg cgctacccag gtcccctact actgcttcct gaaggtggac     1140

acctacaaca gcaccgtcta caagttcctg gccgtgctgc cgcccacggt ccgcgagatc     1200

gtgatcacca agtacggcga cgtctacgtg aacggcttcg gctacctcca cctgggcctc     1260

ctggacgcgg tcaccatcaa cttcaccggc cacggcacgg acgacgacgt gtccggcttc     1320

tggacgatcg ccagcaccaa cttcgtggac gccctgatcg aggtgcaggg caccgccatc     1380

cagcgcatcc tctactgcga cgacccggtg tcccagctga agtgcagcca ggtggcgttc     1440

gacctcgacg acggcttcta ccccatctcc agcaggaacc tcctgtccca cgagcagccg     1500

atcagcttcg tcacgctccc ctccttcaac gaccacagct tcgtcaacat caccgtgtcc     1560

gcttccttcg gtggccactc gggcgctaac ctgatcgcca gcgacaccac gatcaacggc     1620

ttctccagct tctgcgtgga cacgaggcag ttcaccatct ccctcttcta caacgtcacg     1680

aacagctacg gctacgtgtc caagagccag gactccaact gcccgttcac cctccagagc     1740

gtcaacgact acctgtcctt cagcaagttc tgcgtgtcca cgagcctgct ggcttcggcc     1800

tgcaccatcg acctgttcgg ctaccccgag ttcggctccg gcgtcaagtt cacgagcctc     1860

tacttccagt tcaccaaggg cgagctcatc acgggcaccc ccaagccact ggagggcgtc     1920

acggacgtga gcttcatgac cctggacgtg tgcaccaagt acacgatcta cggcttcaag     1980

ggcgagggca tcatcaccct cacgaactca agctttctgg ccggcgtcta ctacacctcc     2040

gacagcggcc agctcctggc cttcaagaac gtgacctcgg gcgccgtcta ctcggtgacg     2100

ccctgctcct tcagcgagca ggctgcctac gtggacgacg acatcgtcgg cgtgatctcc     2160

agcctctcct cttcgacttt caactcaacc cgcgagctgc ccggcttctt ctaccattcc     2220

aaggacgagc tctgatag                                                   2238


<210>  2
<211>  2415
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  2
atggcgaaca agcacctgag ccttagcctc ttcctcgtgc tcctgggcct ctccgcctcc       60

ctcgcctccg gcgtcacaag gtgctcggct aacaccaact tccgcaggtt cttctccaag      120

ttcaacgtgc aggctcccgc cgtggtggtg ctcggcggct acctgccaat cggcgagaac      180

cagggcgtga attcaacgtg gtactgcgcg ggccagcacc ccacggcctc gggcgtccac      240

ggcatcttcg tgagccacat ccgcggcggc cacggcttcg agatcggcat ctcgcaggag      300

cccttcgacc catcgggcta ccagctctac ctgcacaagg ccacgaacgg caacacgaac      360

gctaccgcca ggctgaggat ctgccagttc ccctccatca agaccctggg cccaaccgcg      420

aacaacgacg tgaccacggg caggaactgc ctgttcaaca aggccatccc ggcgcacatg      480

tccgagcaca gcgtcgtggg catcacgtgg gacaacgacc gcgtcaccgt gttcagcgac      540

aagatctact acttctactt caagaacgac tggtccaggg tcgccaccaa gtgctacaac      600

agcggcggct gcgcgatgca gtatgtgtac gagccgacct actacatgct gaacgtgacg      660

tcggcgggcg aggacggcat cagctaccag ccctgcacgg ccaactgcat cggctacgcc      720

gcgaacgtgt tcgccacgga gcccaacggc cacatcccag agggcttctc cttcaacaac      780

tggttcctcc tgtccaacga cagcaccctg gtccacggca aggtcgtgag caaccagccg      840

ctcctggtga actgcctcct ggcgatcccc aagatctacg gcctcggcca gttcttctcc      900

ttcaaccaga cgatcgacgg cgtctgcaac ggcgcggccg tgcagagggc tcccgaggcg      960

ctgaggttca acatcaacga cacctccgtc atcctggcgg agggcagcat cgtgctccac     1020

acggccctgg gcacgaactt ctccttcgtg tgcagcaact ccagcaaccc ccacctcgcc     1080

acgttcgcca tccccctggg cgctacccag gtcccctact actgcttcct gaaggtggac     1140

acctacaaca gcaccgtcta caagttcctg gccgtgctgc cgcccacggt ccgcgagatc     1200

gtgatcacca agtacggcga cgtctacgtg aacggcttcg gctacctcca cctgggcctc     1260

ctggacgcgg tcaccatcaa cttcaccggc cacggcacgg acgacgacgt gtccggcttc     1320

tggacgatcg ccagcaccaa cttcgtggac gccctgatcg aggtgcaggg caccgccatc     1380

cagcgcatcc tctactgcga cgacccggtg tcccagctga agtgcagcca ggtggcgttc     1440

gacctcgacg acggcttcta ccccatctcc agcaggaacc tcctgtccca cgagcagccg     1500

atcagcttcg tcacgctccc ctccttcaac gaccacagct tcgtcaacat caccgtgtcc     1560

gcttccttcg gtggccactc gggcgctaac ctgatcgcca gcgacaccac gatcaacggc     1620

ttctccagct tctgcgtgga cacgaggcag ttcaccatct ccctcttcta caacgtcacg     1680

aacagctacg gctacgtgtc caagagccag gactccaact gcccgttcac cctccagagc     1740

gtcaacgact acctgtcctt cagcaagttc tgcgtgtcca cgagcctgct ggcttcggcc     1800

tgcaccatcg acctgttcgg ctaccccgag ttcggctccg gcgtcaagtt cacgagcctc     1860

tacttccagt tcaccaaggg cgagctcatc acgggcaccc ccaagccact ggagggcgtc     1920

acggacgtga gcttcatgac cctggacgtg tgcaccaagt acacgatcta cggcttcaag     1980

ggcgagggca tcatcaccct cacgaactca agctttctgg ccggcgtcta ctacacctcc     2040

gacagcggcc agctcctggc cttcaagaac gtgacctcgg gcgccgtcta ctcggtgacg     2100

ccctgctcct tcagcgagca ggctgcctac gtggacgacg acatcgtcgg cgtgatctcc     2160

agcctctcct cttcgacttt caactcaacc cgcgagctgc ccggcttctt ctaccattcc     2220

aacgatggct ccaattgcac agagcctgtg ttggtgtaca gcaacatcgg tgtttgcaaa     2280

tctggcagca ttggctacgt cccatcccag tctggccaag tgaagattgc cccgaccgtt     2340

actgggaaca tcagcattcc caccaacttc agcttctacc cctcctacca cagcacccca     2400

cagcgcccct gatag                                                      2415


<210>  3
<211>  716
<212>  PRT
<213>  Porcine epidemic diarrhea virus

<400>  3

Val Thr Arg Cys Ser Ala Asn Thr Asn Phe Arg Arg Phe Phe Ser Lys 
1               5                   10                  15      


Phe Asn Val Gln Ala Pro Ala Val Val Val Leu Gly Gly Tyr Leu Pro 
            20                  25                  30          


Ile Gly Glu Asn Gln Gly Val Asn Ser Thr Trp Tyr Cys Ala Gly Gln 
        35                  40                  45              


His Pro Thr Ala Ser Gly Val His Gly Ile Phe Val Ser His Ile Arg 
    50                  55                  60                  


Gly Gly His Gly Phe Glu Ile Gly Ile Ser Gln Glu Pro Phe Asp Pro 
65                  70                  75                  80  


Ser Gly Tyr Gln Leu Tyr Leu His Lys Ala Thr Asn Gly Asn Thr Asn 
                85                  90                  95      


Ala Thr Ala Arg Leu Arg Ile Cys Gln Phe Pro Ser Ile Lys Thr Leu 
            100                 105                 110         


Gly Pro Thr Ala Asn Asn Asp Val Thr Thr Gly Arg Asn Cys Leu Phe 
        115                 120                 125             


Asn Lys Ala Ile Pro Ala His Met Ser Glu His Ser Val Val Gly Ile 
    130                 135                 140                 


Thr Trp Asp Asn Asp Arg Val Thr Val Phe Ser Asp Lys Ile Tyr Tyr 
145                 150                 155                 160 


Phe Tyr Phe Lys Asn Asp Trp Ser Arg Val Ala Thr Lys Cys Tyr Asn 
                165                 170                 175     


Ser Gly Gly Cys Ala Met Gln Tyr Val Tyr Glu Pro Thr Tyr Tyr Met 
            180                 185                 190         


Leu Asn Val Thr Ser Ala Gly Glu Asp Gly Ile Ser Tyr Gln Pro Cys 
        195                 200                 205             


Thr Ala Asn Cys Ile Gly Tyr Ala Ala Asn Val Phe Ala Thr Glu Pro 
    210                 215                 220                 


Asn Gly His Ile Pro Glu Gly Phe Ser Phe Asn Asn Trp Phe Leu Leu 
225                 230                 235                 240 


Ser Asn Asp Ser Thr Leu Val His Gly Lys Val Val Ser Asn Gln Pro 
                245                 250                 255     


Leu Leu Val Asn Cys Leu Leu Ala Ile Pro Lys Ile Tyr Gly Leu Gly 
            260                 265                 270         


Gln Phe Phe Ser Phe Asn Gln Thr Ile Asp Gly Val Cys Asn Gly Ala 
        275                 280                 285             


Ala Val Gln Arg Ala Pro Glu Ala Leu Arg Phe Asn Ile Asn Asp Thr 
    290                 295                 300                 


Ser Val Ile Leu Ala Glu Gly Ser Ile Val Leu His Thr Ala Leu Gly 
305                 310                 315                 320 


Thr Asn Phe Ser Phe Val Cys Ser Asn Ser Ser Asn Pro His Leu Ala 
                325                 330                 335     


Thr Phe Ala Ile Pro Leu Gly Ala Thr Gln Val Pro Tyr Tyr Cys Phe 
            340                 345                 350         


Leu Lys Val Asp Thr Tyr Asn Ser Thr Val Tyr Lys Phe Leu Ala Val 
        355                 360                 365             


Leu Pro Pro Thr Val Arg Glu Ile Val Ile Thr Lys Tyr Gly Asp Val 
    370                 375                 380                 


Tyr Val Asn Gly Phe Gly Tyr Leu His Leu Gly Leu Leu Asp Ala Val 
385                 390                 395                 400 


Thr Ile Asn Phe Thr Gly His Gly Thr Asp Asp Asp Val Ser Gly Phe 
                405                 410                 415     


Trp Thr Ile Ala Ser Thr Asn Phe Val Asp Ala Leu Ile Glu Val Gln 
            420                 425                 430         


Gly Thr Ala Ile Gln Arg Ile Leu Tyr Cys Asp Asp Pro Val Ser Gln 
        435                 440                 445             


Leu Lys Cys Ser Gln Val Ala Phe Asp Leu Asp Asp Gly Phe Tyr Pro 
    450                 455                 460                 


Ile Ser Ser Arg Asn Leu Leu Ser His Glu Gln Pro Ile Ser Phe Val 
465                 470                 475                 480 


Thr Leu Pro Ser Phe Asn Asp His Ser Phe Val Asn Ile Thr Val Ser 
                485                 490                 495     


Ala Ser Phe Gly Gly His Ser Gly Ala Asn Leu Ile Ala Ser Asp Thr 
            500                 505                 510         


Thr Ile Asn Gly Phe Ser Ser Phe Cys Val Asp Thr Arg Gln Phe Thr 
        515                 520                 525             


Ile Ser Leu Phe Tyr Asn Val Thr Asn Ser Tyr Gly Tyr Val Ser Lys 
    530                 535                 540                 


Ser Gln Asp Ser Asn Cys Pro Phe Thr Leu Gln Ser Val Asn Asp Tyr 
545                 550                 555                 560 


Leu Ser Phe Ser Lys Phe Cys Val Ser Thr Ser Leu Leu Ala Ser Ala 
                565                 570                 575     


Cys Thr Ile Asp Leu Phe Gly Tyr Pro Glu Phe Gly Ser Gly Val Lys 
            580                 585                 590         


Phe Thr Ser Leu Tyr Phe Gln Phe Thr Lys Gly Glu Leu Ile Thr Gly 
        595                 600                 605             


Thr Pro Lys Pro Leu Glu Gly Val Thr Asp Val Ser Phe Met Thr Leu 
    610                 615                 620                 


Asp Val Cys Thr Lys Tyr Thr Ile Tyr Gly Phe Lys Gly Glu Gly Ile 
625                 630                 635                 640 


Ile Thr Leu Thr Asn Ser Ser Phe Leu Ala Gly Val Tyr Tyr Thr Ser 
                645                 650                 655     


Asp Ser Gly Gln Leu Leu Ala Phe Lys Asn Val Thr Ser Gly Ala Val 
            660                 665                 670         


Tyr Ser Val Thr Pro Cys Ser Phe Ser Glu Gln Ala Ala Tyr Val Asp 
        675                 680                 685             


Asp Asp Ile Val Gly Val Ile Ser Ser Leu Ser Ser Ser Thr Phe Asn 
    690                 695                 700                 


Ser Thr Arg Glu Leu Pro Gly Phe Phe Tyr His Ser 
705                 710                 715     


<210>  4
<211>  767
<212>  PRT
<213>  Porcine epidemic diarrhea virus

<400>  4

Val Thr Arg Cys Ser Ala Asn Thr Asn Phe Arg Arg Phe Phe Ser Lys 
1               5                   10                  15      


Phe Asn Val Gln Ala Pro Ala Val Val Val Leu Gly Gly Tyr Leu Pro 
            20                  25                  30          


Ile Gly Glu Asn Gln Gly Val Asn Ser Thr Trp Tyr Cys Ala Gly Gln 
        35                  40                  45              


His Pro Thr Ala Ser Gly Val His Gly Ile Phe Val Ser His Ile Arg 
    50                  55                  60                  


Gly Gly His Gly Phe Glu Ile Gly Ile Ser Gln Glu Pro Phe Asp Pro 
65                  70                  75                  80  


Ser Gly Tyr Gln Leu Tyr Leu His Lys Ala Thr Asn Gly Asn Thr Asn 
                85                  90                  95      


Ala Thr Ala Arg Leu Arg Ile Cys Gln Phe Pro Ser Ile Lys Thr Leu 
            100                 105                 110         


Gly Pro Thr Ala Asn Asn Asp Val Thr Thr Gly Arg Asn Cys Leu Phe 
        115                 120                 125             


Asn Lys Ala Ile Pro Ala His Met Ser Glu His Ser Val Val Gly Ile 
    130                 135                 140                 


Thr Trp Asp Asn Asp Arg Val Thr Val Phe Ser Asp Lys Ile Tyr Tyr 
145                 150                 155                 160 


Phe Tyr Phe Lys Asn Asp Trp Ser Arg Val Ala Thr Lys Cys Tyr Asn 
                165                 170                 175     


Ser Gly Gly Cys Ala Met Gln Tyr Val Tyr Glu Pro Thr Tyr Tyr Met 
            180                 185                 190         


Leu Asn Val Thr Ser Ala Gly Glu Asp Gly Ile Ser Tyr Gln Pro Cys 
        195                 200                 205             


Thr Ala Asn Cys Ile Gly Tyr Ala Ala Asn Val Phe Ala Thr Glu Pro 
    210                 215                 220                 


Asn Gly His Ile Pro Glu Gly Phe Ser Phe Asn Asn Trp Phe Leu Leu 
225                 230                 235                 240 


Ser Asn Asp Ser Thr Leu Val His Gly Lys Val Val Ser Asn Gln Pro 
                245                 250                 255     


Leu Leu Val Asn Cys Leu Leu Ala Ile Pro Lys Ile Tyr Gly Leu Gly 
            260                 265                 270         


Gln Phe Phe Ser Phe Asn Gln Thr Ile Asp Gly Val Cys Asn Gly Ala 
        275                 280                 285             


Ala Val Gln Arg Ala Pro Glu Ala Leu Arg Phe Asn Ile Asn Asp Thr 
    290                 295                 300                 


Ser Val Ile Leu Ala Glu Gly Ser Ile Val Leu His Thr Ala Leu Gly 
305                 310                 315                 320 


Thr Asn Phe Ser Phe Val Cys Ser Asn Ser Ser Asn Pro His Leu Ala 
                325                 330                 335     


Thr Phe Ala Ile Pro Leu Gly Ala Thr Gln Val Pro Tyr Tyr Cys Phe 
            340                 345                 350         


Leu Lys Val Asp Thr Tyr Asn Ser Thr Val Tyr Lys Phe Leu Ala Val 
        355                 360                 365             


Leu Pro Pro Thr Val Arg Glu Ile Val Ile Thr Lys Tyr Gly Asp Val 
    370                 375                 380                 


Tyr Val Asn Gly Phe Gly Tyr Leu His Leu Gly Leu Leu Asp Ala Val 
385                 390                 395                 400 


Thr Ile Asn Phe Thr Gly His Gly Thr Asp Asp Asp Val Ser Gly Phe 
                405                 410                 415     


Trp Thr Ile Ala Ser Thr Asn Phe Val Asp Ala Leu Ile Glu Val Gln 
            420                 425                 430         


Gly Thr Ala Ile Gln Arg Ile Leu Tyr Cys Asp Asp Pro Val Ser Gln 
        435                 440                 445             


Leu Lys Cys Ser Gln Val Ala Phe Asp Leu Asp Asp Gly Phe Tyr Pro 
    450                 455                 460                 


Ile Ser Ser Arg Asn Leu Leu Ser His Glu Gln Pro Ile Ser Phe Val 
465                 470                 475                 480 


Thr Leu Pro Ser Phe Asn Asp His Ser Phe Val Asn Ile Thr Val Ser 
                485                 490                 495     


Ala Ser Phe Gly Gly His Ser Gly Ala Asn Leu Ile Ala Ser Asp Thr 
            500                 505                 510         


Thr Ile Asn Gly Phe Ser Ser Phe Cys Val Asp Thr Arg Gln Phe Thr 
        515                 520                 525             


Ile Ser Leu Phe Tyr Asn Val Thr Asn Ser Tyr Gly Tyr Val Ser Lys 
    530                 535                 540                 


Ser Gln Asp Ser Asn Cys Pro Phe Thr Leu Gln Ser Val Asn Asp Tyr 
545                 550                 555                 560 


Leu Ser Phe Ser Lys Phe Cys Val Ser Thr Ser Leu Leu Ala Ser Ala 
                565                 570                 575     


Cys Thr Ile Asp Leu Phe Gly Tyr Pro Glu Phe Gly Ser Gly Val Lys 
            580                 585                 590         


Phe Thr Ser Leu Tyr Phe Gln Phe Thr Lys Gly Glu Leu Ile Thr Gly 
        595                 600                 605             


Thr Pro Lys Pro Leu Glu Gly Val Thr Asp Val Ser Phe Met Thr Leu 
    610                 615                 620                 


Asp Val Cys Thr Lys Tyr Thr Ile Tyr Gly Phe Lys Gly Glu Gly Ile 
625                 630                 635                 640 


Ile Thr Leu Thr Asn Ser Ser Phe Leu Ala Gly Val Tyr Tyr Thr Ser 
                645                 650                 655     


Asp Ser Gly Gln Leu Leu Ala Phe Lys Asn Val Thr Ser Gly Ala Val 
            660                 665                 670         


Tyr Ser Val Thr Pro Cys Ser Phe Ser Glu Gln Ala Ala Tyr Val Asp 
        675                 680                 685             


Asp Asp Ile Val Gly Val Ile Ser Ser Leu Ser Ser Ser Thr Phe Asn 
    690                 695                 700                 


Ser Thr Arg Glu Leu Pro Gly Phe Phe Tyr His Ser Asn Asp Gly Ser 
705                 710                 715                 720 


Asn Cys Thr Glu Pro Val Leu Val Tyr Ser Asn Ile Gly Val Cys Lys 
                725                 730                 735     


Ser Gly Ser Ile Gly Tyr Val Pro Ser Gln Ser Gly Gln Val Lys Ile 
            740                 745                 750         


Ala Pro Thr Val Thr Gly Asn Ile Ser Ile Pro Thr Asn Phe Ser 
        755                 760                 765         


<210>  5
<211>  72
<212>  DNA
<213>  Hordeum vulgare

<400>  5
atggcgaaca agcacctgag ccttagcctc ttcctcgtgc tcctgggcct ctccgcctcc       60

ctcgcctccg gc                                                           72


<210>  6
<211>  24
<212>  PRT
<213>  Hordeum vulgare

<400>  6

Met Ala Asn Lys His Leu Ser Leu Ser Leu Phe Leu Val Leu Leu Gly 
1               5                   10                  15      


Leu Ser Ala Ser Leu Ala Ser Gly 
            20                  


<210>  7
<211>  756
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  7
atggcgaaca agcacctgag ccttagcctc ttcctcgtgc tcctgggcct ctccgcctcc       60

ctcgcctccg gcgtgtccaa cggctcaatc ccagtggacg aggtcatcca gcacctccgc      120

aactggaact tcacgtggaa catcatcctc accatcctcc tggtggtcct gcagtacggc      180

cactacaagt actccgcctt cctgtacggc gtcaagatgg cgatcctctg gatcctctgg      240

cccctggtgc tcgctctctc cctgttcgac gcttgggcca gcttccaggt gaactgggtc      300

ttcttcgcct tctccatcct catggcgtgc atcaccctca tgctgtggat catgtacttc      360

gtcaacagca tcaggctgtg gaggaggacc cactcctggt ggagcttcaa ccccgagacg      420

gacgctctcc tgaccacctc cgtcatgggc aggcaggtgt gcatccccgt cctgggcgcc      480

ccaaccggcg tgaccctcac gctgctgtcg ggcaccctcc tggtggaggg ctacaaggtg      540

gctaccggcg tgcaggtcag ccagctcccc aacttcgtga ccgtcgccaa ggcgaccacg      600

acgatcgtgt acggcagggt gggcaggtcg gtgaacgctt cctcgggcac cggctgggcg      660

ttctacgtga ggtccaagca cggcgactac agcgcggtga gcaacccctc gtcggtcctg      720

actgattcgg agaaggtcct gcacctcgtg tagtga                                756


<210>  8
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  8

Met Ala Asn Lys His Leu Ser Leu Ser Leu Phe Leu Val Leu Leu Gly 
1               5                   10                  15      


Leu Ser Ala Ser Leu Ala Ser Gly Val Ser Asn Gly Ser Ile Pro Val 
            20                  25                  30          


Asp Glu Val Ile Gln His Leu Arg Asn Trp Asn Phe Thr Trp Asn Ile 
        35                  40                  45              


Ile Leu Thr Ile Leu Leu Val Val Leu Gln Tyr Gly His Tyr Lys Tyr 
    50                  55                  60                  


Ser Ala Phe Leu Tyr Gly Val Lys Met Ala Ile Leu Trp Ile Leu Trp 
65                  70                  75                  80  


Pro Leu Val Leu Ala Leu Ser Leu Phe Asp Ala Trp Ala Ser Phe Gln 
                85                  90                  95      


Val Asn Trp Val Phe Phe Ala Phe Ser Ile Leu Met Ala Cys Ile Thr 
            100                 105                 110         


Leu Met Leu Trp Ile Met Tyr Phe Val Asn Ser Ile Arg Leu Trp Arg 
        115                 120                 125             


Arg Thr His Ser Trp Trp Ser Phe Asn Pro Glu Thr Asp Ala Leu Leu 
    130                 135                 140                 


Thr Thr Ser Val Met Gly Arg Gln Val Cys Ile Pro Val Leu Gly Ala 
145                 150                 155                 160 


Pro Thr Gly Val Thr Leu Thr Leu Leu Ser Gly Thr Leu Leu Val Glu 
                165                 170                 175     


Gly Tyr Lys Val Ala Thr Gly Val Gln Val Ser Gln Leu Pro Asn Phe 
            180                 185                 190         


Val Thr Val Ala Lys Ala Thr Thr Thr Ile Val Tyr Gly Arg Val Gly 
        195                 200                 205             


Arg Ser Val Asn Ala Ser Ser Gly Thr Gly Trp Ala Phe Tyr Val Arg 
    210                 215                 220                 


Ser Lys His Gly Asp Tyr Ser Ala Val Ser Asn Pro Ser Ser Val Leu 
225                 230                 235                 240 


Thr Asp Ser Glu Lys Val Leu His Leu Val 
                245                 250 


<210>  9
<211>  713
<212>  PRT
<213>  Porcine epidemic diarrhea virus

<400>  9

Val Thr Arg Cys Gln Ser Thr Ile Asn Phe Arg Arg Phe Phe Ser Lys 
1               5                   10                  15      


Phe Asn Val Gln Ala Pro Ala Val Val Val Leu Gly Gly Tyr Leu Pro 
            20                  25                  30          


Ser Met Asn Ser Ser Ser Trp Tyr Cys Gly Thr Gly Ile Glu Thr Asp 
        35                  40                  45              


Ser Gly Val His Gly Ile Phe Leu Ser Tyr Ile Asp Ser Gly Gln Gly 
    50                  55                  60                  


Phe Glu Ile Gly Ile Ser Gln Glu Pro Phe Asp Pro Ser Gly Tyr Gln 
65                  70                  75                  80  


Leu Tyr Leu His Lys Ala Thr Asn Gly Asn Thr Asn Ala Ile Ala Arg 
                85                  90                  95      


Leu Arg Ile Cys Gln Phe Pro Asp Asn Lys Thr Leu Gly Pro Thr Val 
            100                 105                 110         


Asn Asp Val Thr Thr Gly Arg Asn Cys Leu Phe Asn Lys Ala Ile Pro 
        115                 120                 125             


Ala Tyr Leu Gln Asp Gly Lys Asn Ile Val Val Gly Ile Thr Trp Asp 
    130                 135                 140                 


Asn Asp Arg Val Thr Val Phe Ala Asp Lys Ile Tyr His Phe Tyr Leu 
145                 150                 155                 160 


Lys Asn Asp Trp Ser Arg Val Ala Thr Arg Cys Tyr Asn Lys Arg Ser 
                165                 170                 175     


Cys Ala Met Gln Tyr Val Tyr Thr Pro Thr Tyr Tyr Met Leu Asn Val 
            180                 185                 190         


Thr Ser Ala Gly Glu Asp Gly Ile Tyr Tyr Glu Pro Cys Thr Ala Asn 
        195                 200                 205             


Cys Ser Gly Tyr Ala Ala Asn Val Phe Ala Thr Asp Ser Asn Gly His 
    210                 215                 220                 


Ile Pro Glu Gly Phe Ser Phe Asn Asn Trp Phe Leu Leu Ser Asn Asp 
225                 230                 235                 240 


Ser Thr Leu Leu His Gly Lys Val Val Ser Asn Gln Pro Leu Leu Val 
                245                 250                 255     


Asn Cys Leu Leu Ala Ile Pro Lys Ile Tyr Gly Leu Gly Gln Phe Phe 
            260                 265                 270         


Ser Phe Asn Gln Thr Met Asp Gly Val Cys Asn Gly Ala Ala Ala Gln 
        275                 280                 285             


Arg Ala Pro Glu Ala Leu Arg Phe Asn Ile Asn Asp Thr Ser Val Ile 
    290                 295                 300                 


Leu Ala Glu Gly Ser Ile Val Leu His Thr Ala Leu Gly Thr Asn Leu 
305                 310                 315                 320 


Ser Phe Val Cys Ser Asn Ser Ser Asp Pro His Leu Ala Ile Phe Ala 
                325                 330                 335     


Ile Pro Leu Gly Ala Thr Glu Val Pro Tyr Tyr Cys Phe Leu Lys Val 
            340                 345                 350         


Asp Thr Tyr Asn Ser Thr Val Tyr Lys Phe Leu Ala Val Leu Pro Pro 
        355                 360                 365             


Thr Val Arg Glu Ile Val Ile Thr Lys Tyr Gly Asp Val Tyr Val Asn 
    370                 375                 380                 


Gly Phe Gly Tyr Leu His Leu Gly Leu Leu Asp Ala Val Thr Ile Asn 
385                 390                 395                 400 


Phe Thr Gly His Gly Thr Asp Asp Asp Val Ser Gly Phe Trp Thr Ile 
                405                 410                 415     


Ala Ser Thr Asn Phe Val Asp Ala Leu Ile Glu Val Gln Gly Thr Ala 
            420                 425                 430         


Ile Gln Arg Ile Leu Tyr Cys Asp Asp Pro Val Ser Gln Leu Lys Cys 
        435                 440                 445             


Ser Gln Val Ala Phe Asp Leu Asp Asp Gly Phe Tyr Pro Ile Ser Ser 
    450                 455                 460                 


Arg Asn Leu Leu Ser His Glu Gln Pro Ile Ser Phe Val Thr Leu Pro 
465                 470                 475                 480 


Ser Phe Asn Asp His Ser Phe Val Asn Ile Thr Val Ser Ala Ala Phe 
                485                 490                 495     


Gly Gly His Ser Gly Ala Asn Leu Ile Ala Ser Asp Thr Thr Ile Asn 
            500                 505                 510         


Gly Phe Ser Ser Phe Cys Val Asp Thr Arg Gln Phe Thr Ile Thr Leu 
        515                 520                 525             


Phe Tyr Asn Val Thr Asn Ser Tyr Gly Tyr Val Ser Lys Ser Gln Asp 
    530                 535                 540                 


Ser Asn Cys Pro Phe Thr Leu Gln Ser Val Asn Asp Tyr Leu Ser Phe 
545                 550                 555                 560 


Ser Lys Phe Cys Val Ser Thr Ser Leu Leu Ala Gly Ala Cys Thr Ile 
                565                 570                 575     


Asp Leu Phe Gly Tyr Pro Glu Phe Gly Ser Gly Val Lys Phe Thr Ser 
            580                 585                 590         


Leu Tyr Phe Gln Phe Thr Lys Gly Glu Leu Ile Thr Gly Thr Pro Lys 
        595                 600                 605             


Pro Leu Glu Gly Val Thr Asp Val Ser Phe Met Thr Leu Asp Val Cys 
    610                 615                 620                 


Thr Lys Tyr Thr Ile Tyr Gly Phe Lys Gly Glu Gly Ile Ile Thr Leu 
625                 630                 635                 640 


Thr Asn Ser Ser Phe Leu Ala Gly Val Tyr Tyr Thr Ser Asp Ser Gly 
                645                 650                 655     


Gln Leu Leu Ala Phe Lys Asn Val Thr Ser Gly Ala Val Tyr Ser Val 
            660                 665                 670         


Thr Pro Cys Ser Phe Ser Glu Gln Ala Ala Tyr Val Asp Asp Asp Ile 
        675                 680                 685             


Val Gly Val Ile Ser Ser Leu Ser Asn Ser Thr Phe Asn Asn Thr Arg 
    690                 695                 700                 


Glu Leu Pro Gly Phe Phe Tyr His Ser 
705                 710             


<210>  10
<211>  1392
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  10
atggcgaaca agcacctgag ccttagcctc ttcctcgtgc tcctgggcct ctccgcctcc       60

ctcgcctccg gcgtttcctt ccaggacagg ggcaggaagc gcgtgcccct ctcgctctac      120

gcgcccctca gggtcaccaa cgacaagccg ctcagcaagg tgctggccaa taacgcggtc      180

cccacgaaca agggcaataa ggaccagcag atcggctact ggaacgagca gatccggtgg      240

aggatgagga ggggcgagag gatcgagcag ccctccaact ggcacttcta ctacctcggc      300

acgggcccac acgcggacct gaggtaccgc accaggacgg agggcgtgtt ctgggtggcc      360

aaggagggcg ctaagacgga gcccaccaat ctcggcgtgc gcaaggcctc ggagaagccg      420

atcatcccca acttctccca gcagctgccg agcgtggtcg agatcgtgga gccaaacacc      480

ccgcccacct cgcgcgctaa ttcccgcagc aggtcccgcg gcaacggcaa caataggagc      540

cgctccccga gcaacaacag gggcaataac cagtcccgcg gcaacagcca gaaccggggc      600

aataaccagg gcaggggcgc cagccagaac aggggcggca ataacaacaa taacaacaag      660

tcccgcaatc agagcaagaa caggaaccag tcgaatgacc gcggcggcgt gacctcgcgc      720

gacgacctcg tggcggccgt caaggacgcg ctcaagtccc tgggcatcgg cgagaacccg      780

gacaagctga agcagcagca gaagccaaag caggagaggt cggactccag cggcaagaac      840

accccgaaga agaataagtc ccgcgccacg agcaaggaga gggacctgaa ggacatcccc      900

gagtggcgca ggatcccgaa gggcgagaac tcggtggcgg cctgcttcgg cccccgcggc      960

ggcttcaaga atttcggcga cgcggagttc gtggagaagg gcgtggacgc ttcgggctac     1020

gctcagatcg ccagcctggc tccaaacgtg gcggccctcc tgttcggtgg caacgtggcg     1080

gtcagggagc tggcggacag ctacgagatc acctacaact acaagatgac ggtgccgaag     1140

tccgacccca atgtcgagct cctggtgagc caggtcgacg ccttcaagac cggcaacgcc     1200

aagccgcagc gcaagaagga gaagaagaac aagagggaga cgacgcagca gctcaatgag     1260

gaggccatct acgacgacgt gggcgtccca tcggacgtga cgcacgccaa cctggagtgg     1320

gacaccgctg tcgacggcgg ggatactgct gtggagatca tcaacgagat tttcgatact     1380

gggaattagt ga                                                         1392


<210>  11
<211>  462
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  11

Met Ala Asn Lys His Leu Ser Leu Ser Leu Phe Leu Val Leu Leu Gly 
1               5                   10                  15      


Leu Ser Ala Ser Leu Ala Ser Gly Val Ser Phe Gln Asp Arg Gly Arg 
            20                  25                  30          


Lys Arg Val Pro Leu Ser Leu Tyr Ala Pro Leu Arg Val Thr Asn Asp 
        35                  40                  45              


Lys Pro Leu Ser Lys Val Leu Ala Asn Asn Ala Val Pro Thr Asn Lys 
    50                  55                  60                  


Gly Asn Lys Asp Gln Gln Ile Gly Tyr Trp Asn Glu Gln Ile Arg Trp 
65                  70                  75                  80  


Arg Met Arg Arg Gly Glu Arg Ile Glu Gln Pro Ser Asn Trp His Phe 
                85                  90                  95      


Tyr Tyr Leu Gly Thr Gly Pro His Ala Asp Leu Arg Tyr Arg Thr Arg 
            100                 105                 110         


Thr Glu Gly Val Phe Trp Val Ala Lys Glu Gly Ala Lys Thr Glu Pro 
        115                 120                 125             


Thr Asn Leu Gly Val Arg Lys Ala Ser Glu Lys Pro Ile Ile Pro Asn 
    130                 135                 140                 


Phe Ser Gln Gln Leu Pro Ser Val Val Glu Ile Val Glu Pro Asn Thr 
145                 150                 155                 160 


Pro Pro Thr Ser Arg Ala Asn Ser Arg Ser Arg Ser Arg Gly Asn Gly 
                165                 170                 175     


Asn Asn Arg Ser Arg Ser Pro Ser Asn Asn Arg Gly Asn Asn Gln Ser 
            180                 185                 190         


Arg Gly Asn Ser Gln Asn Arg Gly Asn Asn Gln Gly Arg Gly Ala Ser 
        195                 200                 205             


Gln Asn Arg Gly Gly Asn Asn Asn Asn Asn Asn Lys Ser Arg Asn Gln 
    210                 215                 220                 


Ser Lys Asn Arg Asn Gln Ser Asn Asp Arg Gly Gly Val Thr Ser Arg 
225                 230                 235                 240 


Asp Asp Leu Val Ala Ala Val Lys Asp Ala Leu Lys Ser Leu Gly Ile 
                245                 250                 255     


Gly Glu Asn Pro Asp Lys Leu Lys Gln Gln Gln Lys Pro Lys Gln Glu 
            260                 265                 270         


Arg Ser Asp Ser Ser Gly Lys Asn Thr Pro Lys Lys Asn Lys Ser Arg 
        275                 280                 285             


Ala Thr Ser Lys Glu Arg Asp Leu Lys Asp Ile Pro Glu Trp Arg Arg 
    290                 295                 300                 


Ile Pro Lys Gly Glu Asn Ser Val Ala Ala Cys Phe Gly Pro Arg Gly 
305                 310                 315                 320 


Gly Phe Lys Asn Phe Gly Asp Ala Glu Phe Val Glu Lys Gly Val Asp 
                325                 330                 335     


Ala Ser Gly Tyr Ala Gln Ile Ala Ser Leu Ala Pro Asn Val Ala Ala 
            340                 345                 350         


Leu Leu Phe Gly Gly Asn Val Ala Val Arg Glu Leu Ala Asp Ser Tyr 
        355                 360                 365             


Glu Ile Thr Tyr Asn Tyr Lys Met Thr Val Pro Lys Ser Asp Pro Asn 
    370                 375                 380                 


Val Glu Leu Leu Val Ser Gln Val Asp Ala Phe Lys Thr Gly Asn Ala 
385                 390                 395                 400 


Lys Pro Gln Arg Lys Lys Glu Lys Lys Asn Lys Arg Glu Thr Thr Gln 
                405                 410                 415     


Gln Leu Asn Glu Glu Ala Ile Tyr Asp Asp Val Gly Val Pro Ser Asp 
            420                 425                 430         


Val Thr His Ala Asn Leu Glu Trp Asp Thr Ala Val Asp Gly Gly Asp 
        435                 440                 445             


Thr Ala Val Glu Ile Ile Asn Glu Ile Phe Asp Thr Gly Asn 
    450                 455                 460         


<210>  12
<211>  558
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  12
atggcgaaca agcacctgag ccttagcctc ttcctcgtgc tcctgggcct ctccgcctcc       60

ctcgcctccg gctcccacga gcagccgatc agcttcgtca cgctcccctc cttcaacgac      120

cacagcttcg tcaacatcac cgtgtccgct tccttcggtg gccactcggg cgctaacctg      180

atcgccagcg acaccacgat caacggcttc tccagcttct gcgtggacac gaggcagttc      240

accatctccc tcttctacaa cgtcacgaac agctacggct acgtgtccaa gagccaggac      300

tccaactgcc cgttcaccct ccagagcgtc aacgactacc tgtccttcag caagttctgc      360

gtgtccacga gcctgctggc ttcggcctgc accatcgacc tgttcggcta ccccgagttc      420

ggctccggcg tcaagttcac gagcctctac ttccagttca ccaagggcga gctcatcacg      480

ggcaccccca agccactgga gggcgtcacg gacgtgttct acccctccta ccacagcacc      540

ccacagcgcc cctgatag                                                    558


<210>  13
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DC3 nucletotide sequence

<400>  13
ttctacccct cctaccacag caccccacag cgcccc                                 36


<210>  14
<211>  309
<212>  DNA
<213>  Escherichia coli

<400>  14
gccccgcagt ccatcaccga gctctgctcc gagtaccaca acacccagat ctacaccatc       60

aacgacaaga tcctctccta caccgagagc atggccggca agcgcgagat ggtgatcatc      120

accttcaagt ccggcgccac cttccaggtg gaggtgccgg gctcccagca catcgactcc      180

cagaagaagg ccatcgagcg catgaaggac accctccgca tcacctacct caccgagacc      240

aagatcgaca agctctgcgt gtggaacaac aagaccccga actccatcgc cgccatcagc      300

atggagaac                                                              309


<210>  15
<211>  103
<212>  PRT
<213>  Escherichia coli

<400>  15

Ala Pro Gln Ser Ile Thr Glu Leu Cys Ser Glu Tyr His Asn Thr Gln 
1               5                   10                  15      


Ile Tyr Thr Ile Asn Asp Lys Ile Leu Ser Tyr Thr Glu Ser Met Ala 
            20                  25                  30          


Gly Lys Arg Glu Met Val Ile Ile Thr Phe Lys Ser Gly Ala Thr Phe 
        35                  40                  45              


Gln Val Glu Val Pro Gly Ser Gln His Ile Asp Ser Gln Lys Lys Ala 
    50                  55                  60                  


Ile Glu Arg Met Lys Asp Thr Leu Arg Ile Thr Tyr Leu Thr Glu Thr 
65                  70                  75                  80  


Lys Ile Asp Lys Leu Cys Val Trp Asn Asn Lys Thr Pro Asn Ser Ile 
                85                  90                  95      


Ala Ala Ile Ser Met Glu Asn 
            100             


<210>  16
<211>  3002
<212>  DNA
<213>  Zea mays

<400>  16
cggtatgaat ttggaaacaa attcagtact tttaaaaaaa tttgttgtag ggagcaaata       60

atacataaaa taatttatgc attattttat tttttatttg taataatatg cttgaaacga      120

taattcagta tgcatgttgt gccagtgtac tacacgggcg gggggagggg attgagtggg      180

ccagcgcggt gcgtagggta gatgggctga aattgataac tcaagtccga ctaggttctc      240

tttttatttc ccttcctttt ctattttcct ttcttttaat tttcatgctt tcaaactaaa      300

ttcaaattcg agttttgaat ttcagcttct aaattgtaca ctaaaattat atgataaggt      360

aacccctact attactttta atttttttat tctaccccat attgtttact taggggagaa      420

taattgactt aatcacattc ttcctaggtt tcaattctca atctttcaaa tccacatttt      480

tagatttcta ttttgaattt aaataccagt ttggatttag agttcaattt caaaatacac      540

aaccaaaata ccagcatgaa tgcaaatata ttttatgttt atgtatttac ttttctttta      600

tactttgctc aaaatagtta ttttcatgta tgaaactcaa taagcaagga actcacgtta      660

ttatataacc taataggaat aatttaggta acataattta tcatcctctt gatttaaaag      720

agatatgcct ccagaataag acacatacta aaaataactc taatattgaa taactaaagt      780

cgtacaaatc tctactatta ttcctataaa ataataaaga actagctaca acttctttaa      840

ggcattattc agggtttaca gcttgagagg catgaaccca tcctgtatac tcctggactt      900

ggaagacaaa atgtcaacca aagtgaaagg ttttcttatg gttgctgcta agagatagat      960

tgaacactag atctctccta agacgtcagg gcatgcgttt agactcctac acatgcgaaa     1020

actgcatctt acagttggaa gaaactatat ctcaccactt cctgcggtgt aactttgccc     1080

aaagatgttg gctcactgtt ggaatcactc cgccccgaac tttggatcta acgcttgcag     1140

tgctacatat tagagcaaga ctaacaatgc cgtggagaat ggaaggtatt ataaccatgt     1200

catggtgcat atggaaatgt cgaaataact ggatattcga aaacataccg ccaacggtgg     1260

cggcctgcaa ggaaatgttc aagactgaaa tgaactacat ctgctaccaa gttaagctcg     1320

agacaggagc taaaagtaga aactggatac aacactttgt aacatagtga cactcccctt     1380

ttcctttctt ttaccttaga actatacata caatccacat tcaataaaaa tttgtaggta     1440

cgccatacac actaccggaa tccggctctt tgccgagtgt gaggcgcttt gtcgagtgct     1500

ttttgtccag cactcggcaa aaaagtcttt gccatgtgcc gcactcggca aagtcctgct     1560

ctcggtaacg accgcgttta ccgagagcag gactctcgac acagaaatac actcgacaaa     1620

gaaatctttg ccgagagcca aacactcggc gaacggcagc gctcggcaaa gggtcgtcag     1680

ccgccgtcta aagctgacgg tcgttatctt tgtcgagtgc cccctcgtcc gacactcagt     1740

agagcaagct tgccgagtgc catccttgga cactcgataa agtatatttt attttttttt     1800

attttgccaa ccaaactttt tgtggtatgt tcctacacta tgtagatcta catgtaccat     1860

tttggcacaa ttacaaaaat gttttctata actattagat ttagttcgtt tatttgaatt     1920

tcttcggaaa attcacatat gaactgcaag tcactcgaaa catgaaaaac cgtgcatgca     1980

aaataaatga tatgcatgtt atctagcaca agttacgacc gaattcagaa gcagaccaga     2040

atcttcaagc accatgctca ctaaacatga ccgtgaactt gttatccagt tgtttaaaaa     2100

ttgtataaaa cacaaataaa gtcagaaatt aatgaaactt gtccacatgt catgatatca     2160

tatatagagg ttgtgataaa aatttgataa tgtttcggta aagttgtgac gtactatgtg     2220

tagaaaccta agtgacctac acataaaatc atagagtttc aatgtagttc actcgacaaa     2280

gactttgtca agtgtccgat aaaaagtatt cagcaaagaa gccgttgtcg atttactgtt     2340

cgtcgagatc tctttgccga gtgtcacact aggcaaagtc tttacggagt gtttttcagg     2400

ctttgacact cggcaaagcg ctcgattcca gtagtgacag taatttgcat caaaaatagc     2460

cgagagattt aaaatgagtc aactaataga ccaactaatt attagctatt agtcgttagc     2520

ttctttaatc taagctaaaa ccaactaata gcttatttgt tgaattacaa ttagctcaac     2580

ggaattctct gttttttcta taaaaaaaag ggaaactgcc cctcatttac agcaaactgt     2640

ccgctgcctg tcgtccagat acaatgaacg tacctagtag gaactctttt acacgctcgg     2700

tcgctcgccg cggatcggag tcccaggaac acgacaccac tgtggaacac gacaaagtct     2760

gctcagaggc ggccacaccc tggcgtgcac cgagccggag cccggataag cacggtaagg     2820

agagtacggc gggacgtggc gacccgtgtg tctgctgcca cgcagccttc ctccacgtag     2880

ccgcgcggcc gcgccacgta ccagggcccg gcgctggtat aaatgcgcgc cacctccgct     2940

ttagttctgc atacagccaa cccaacacac acccgagcat atcacagtga cagacactac     3000

ac                                                                    3002


<210>  17
<211>  2520
<212>  DNA
<213>  Zea mays

<400>  17
gcgctccctg acgctgtctt gggagagctg caagatgaga cactccatcc cgcgcagccc       60

tgtcgtggcg tcctcctgga tggacacctg catcgctgtc gccctccacc aactcacctg      120

aacgaagaat agaataaaaa atggagggag ctgagggggc agtggttgcg ctgtagggag      180

gagagagacc gcgtcattat aagactatct gcaaccgtta cctctaaatt tttccctcta      240

tatcattttt tccccatatt ttccccccta ttttttcatc tcccgcaacg gtttctccta      300

aatactcccc ctatatctca ctaccactat aaaatattat tttttatacc aactatcaat      360

tttttatcta ctaacaatta ctcgtggacc cacagcacag tgtttaggag atgaacagtg      420

acacgctata tctgggggga gagagaaaga ggccggcgcg tagggggcgc cgtaggggca      480

ctgctgcggc tgtagagtac cccctacacg ccgcatgcaa gggaaggggg ctgtcagggg      540

ggcaatgttg cgcatagcct aaagagcgga tgaagcggct tgcaatttgc acgctggatt      600

cataaatagt gcatattact aaaaaaaagg gtggggatag gtatagagag tctattagag      660

ttgatctaag acccggttta tttcagatta taatctgtcc ggattatata atccagcgca      720

aataatacag taggtaaaca aacaactaga ttatgggttc agattatata atctaaaccc      780

cagattatga taatctcata atctcctcaa gagtagctta ttggagatta ttttggcaaa      840

agacccacta cccatggtta tgtaaataga aattataata tatatcatct tttttctcac      900

cttaaataaa caaataaggg tattgttgtc tttatgaata atctacattt gtataatcta      960

aactaccaaa caactacatc tagattataa tctggattat ataatttaaa ttataatcta     1020

gattatataa tttataagct gaaacaaccc ggccctaaag cactatcgta tcacctatct     1080

gaaataagtc acgggtttcg aacgtccact tgcgtcgcac ggaattgcat gtttcttgtt     1140

ggaagcatat tcacgcaatc tccacacata aaggtttatg tataaactta catttagctc     1200

agtttaatta cagtcttatt tggatgcata tgtatggttc tcaatccata taagttagag     1260

taaaaaataa gtttaaattt tatcttaatt cactccaaca tatatggatt gagtacaata     1320

ctcatgtgca tccaaacaaa ctacttatat tgaggtgaat ttggatagaa attaaactaa     1380

cttacacact aagccaatct ttactatatt aaagcaccag tttcaacgat cgtcccgcgt     1440

caatattatt aaaaaactcc tacatttctt tataatcaac ccgcactctt ataatctctt     1500

ctctactact ataataagag agtttatgta caaaataagg tgaaattatg tataagtgtt     1560

ctggatattg gttgttggct ccatattcac acaacctaat caatagaaaa catatgtttt     1620

attaaaacaa aatttatcat atatcatata tatatatata aaccgtagca atgcacgggc     1680

atataactag tgcaacttaa tacatgtgtg tattaagatg aataagaggg tatccaaata     1740

aaaaacttgt tcgcttacgt ctggatcgaa aggggttgga aacgattaaa tctcttccta     1800

gtcaaaattg aatagaagga gatttaatct ctcccaatcc ccttcgatca tccaggtgca     1860

accgtataag tcctaaagtg gtgaggaaca cgaaacaacc atgcattggc atgtaaagct     1920

ccaagaattt gttgtatcct taacaactca cagaacatca accaaaattg cacgtcaagg     1980

gtattgggta agaaacaatc aaacaaatcc tctctgtgtg caaagaaaca cggtgagtca     2040

tgccgagatc atactcatct gatatacatg cttacagctc acaagacatt acaaacaact     2100

catattgcat tacaaagatc gtttcatgaa aaataaaata ggccggacag gacaaaaatc     2160

cttgacgtgt aaagtaaatt tacaacaaaa aaaaagccat atgtcaagct aaatctaatt     2220

cgttttacgt agatcaacaa cctgtagaag gcaacaaaac tgagccacgc agaagtacag     2280

aatgattcca gatgaaccat cgacgtgcta cgtaaagaga gtgacgagtc atatacattt     2340

ggcaagaaac catgaagctg cctacagccg tctcggtggc ataagaacac aagaaattgt     2400

gttaattaat caaagctata aataacgctc gcatgcctgt gcacttctcc atcaccacca     2460

ctgggtcttc agaccattag ctttatctac tccagagcgc agaagaaccc gatcgacacc     2520


<210>  18
<211>  6510
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  18
ggcgcgccgg tatgaatttg gaaacaaatt cagtactttt aaaaaaattt gttgtaggga       60

gcaaataata cataaaataa tttatgcatt attttatttt ttatttgtaa taatatgctt      120

gaaacgataa ttcagtatgc atgttgtgcc agtgtactac acgggcgggg ggaggggatt      180

gagtgggcca gcgcggtgcg tagggtagat gggctgaaat tgataactca agtccgacta      240

ggttctcttt ttatttccct tccttttcta ttttcctttc ttttaatttt catgctttca      300

aactaaattc aaattcgagt tttgaatttc agcttctaaa ttgtacacta aaattatatg      360

ataaggtaac ccctactatt acttttaatt tttttattct accccatatt gtttacttag      420

gggagaataa ttgacttaat cacattcttc ctaggtttca attctcaatc tttcaaatcc      480

acatttttag atttctattt tgaatttaaa taccagtttg gatttagagt tcaatttcaa      540

aatacacaac caaaatacca gcatgaatgc aaatatattt tatgtttatg tatttacttt      600

tcttttatac tttgctcaaa atagttattt tcatgtatga aactcaataa gcaaggaact      660

cacgttatta tataacctaa taggaataat ttaggtaaca taatttatca tcctcttgat      720

ttaaaagaga tatgcctcca gaataagaca catactaaaa ataactctaa tattgaataa      780

ctaaagtcgt acaaatctct actattattc ctataaaata ataaagaact agctacaact      840

tctttaaggc attattcagg gtttacagct tgagaggcat gaacccatcc tgtatactcc      900

tggacttgga agacaaaatg tcaaccaaag tgaaaggttt tcttatggtt gctgctaaga      960

gatagattga acactagatc tctcctaaga cgtcagggca tgcgtttaga ctcctacaca     1020

tgcgaaaact gcatcttaca gttggaagaa actatatctc accacttcct gcggtgtaac     1080

tttgcccaaa gatgttggct cactgttgga atcactccgc cccgaacttt ggatctaacg     1140

cttgcagtgc tacatattag agcaagacta acaatgccgt ggagaatgga aggtattata     1200

accatgtcat ggtgcatatg gaaatgtcga aataactgga tattcgaaaa cataccgcca     1260

acggtggcgg cctgcaagga aatgttcaag actgaaatga actacatctg ctaccaagtt     1320

aagctcgaga caggagctaa aagtagaaac tggatacaac actttgtaac atagtgacac     1380

tccccttttc ctttctttta ccttagaact atacatacaa tccacattca ataaaaattt     1440

gtaggtacgc catacacact accggaatcc ggctctttgc cgagtgtgag gcgctttgtc     1500

gagtgctttt tgtccagcac tcggcaaaaa agtctttgcc atgtgccgca ctcggcaaag     1560

tcctgctctc ggtaacgacc gcgtttaccg agagcaggac tctcgacaca gaaatacact     1620

cgacaaagaa atctttgccg agagccaaac actcggcgaa cggcagcgct cggcaaaggg     1680

tcgtcagccg ccgtctaaag ctgacggtcg ttatctttgt cgagtgcccc ctcgtccgac     1740

actcagtaga gcacgcgccg gtatgaattt ggaaacaaat tcagtacttt taaaaaaatt     1800

tgttgtaggg agcaaataat acataaaata atttatgcat tattttattt tttatttgta     1860

ataatatgct tgaaacgata attcagtatg catgttgtgc cagtgtacta cacgggcggg     1920

gggaggggat tgagtgggcc agcgcggtgc gtagggtaga tgggctgaaa ttgataactc     1980

aagtccgact aggttctctt tttatttccc ttccttttct attttccttt cttttaattt     2040

tcatgctttc aaactaaatt caaattcgag ttttgaattt cagcttctaa attgtacact     2100

aaaattatat gataaggtaa cccctactat tacttttaat ttttttattc taccccatat     2160

tgtttactta ggggagaata attgacttaa tcacattctt cctaggtttc aattctcaat     2220

ctttcaaatc cacattttta gatttctatt ttgaatttaa ataccagttt ggatttagag     2280

ttcaatttca aaatacacaa ccaaaatacc agcatgaatg caaatatatt ttatgtttat     2340

gtatttactt ttcttttata ctttgctcaa aatagttatt ttcatgtatg aaactcaata     2400

agcaaggaac tcacgttatt atataaccta ataggaataa tttaggtaac ataatttatc     2460

atcctcttga tttaaaagag atatgcctcc agaataagac acatactaaa aataactcta     2520

atattgaata actaaagtcg tacaaatctc tactattatt cctataaaat aataaagaac     2580

tagctacaac ttctttaagg cattattcag ggtttacagc ttgagaggca tgaacccatc     2640

ctgtatactc ctggacttgg aagacaaaat gtcaaccaaa gtgaaaggtt ttcttatggt     2700

tgctgctaag agatagattg aacactagat ctctcctaag acgtcagggc atgcgtttag     2760

actcctacac atgcgaaaac tgcatcttac agttggaaga aactatatct caccacttcc     2820

tgcggtgtaa ctttgcccaa agatgttggc tcactgttgg aatcactccg ccccgaactt     2880

tggatctaac gcttgcagtg ctacatatta gagcaagact aacaatgccg tggagaatgg     2940

aaggtattat aaccatgtca tggtgcatat ggaaatgtcg aaataactgg atattcgaaa     3000

acataccgcc aacggtggcg gcctgcaagg aaatgttcaa gactgaaatg aactacatct     3060

gctaccaagt taagctcgag acaggagcta aaagtagaaa ctggatacaa cactttgtaa     3120

catagtgaca ctcccctttt cctttctttt accttagaac tatacataca atccacattc     3180

aataaaaatt tgtaggtacg ccatacacac taccggaatc cggctctttg ccgagtgtga     3240

ggcgctttgt cgagtgcttt ttgtccagca ctcggcaaaa aagtctttgc catgtgccgc     3300

actcggcaaa gtcctgctct cggtaacgac cgcgtttacc gagagcagga ctctcgacac     3360

agaaatacac tcgacaaaga aatctttgcc gagagccaaa cactcggcga acggcagcgc     3420

tcggcaaagg gtcgtcagcc gccgtctaaa gctgacggtc gttatctttg tcgagtgccc     3480

cctcgtccga cactcagtag agcacgcgcc ggtatgaatt tggaaacaaa ttcagtactt     3540

ttaaaaaaat ttgttgtagg gagcaaataa tacataaaat aatttatgca ttattttatt     3600

ttttatttgt aataatatgc ttgaaacgat aattcagtat gcatgttgtg ccagtgtact     3660

acacgggcgg ggggagggga ttgagtgggc cagcgcggtg cgtagggtag atgggctgaa     3720

attgataact caagtccgac taggttctct ttttatttcc cttccttttc tattttcctt     3780

tcttttaatt ttcatgcttt caaactaaat tcaaattcga gttttgaatt tcagcttcta     3840

aattgtacac taaaattata tgataaggta acccctacta ttacttttaa tttttttatt     3900

ctaccccata ttgtttactt aggggagaat aattgactta atcacattct tcctaggttt     3960

caattctcaa tctttcaaat ccacattttt agatttctat tttgaattta aataccagtt     4020

tggatttaga gttcaatttc aaaatacaca accaaaatac cagcatgaat gcaaatatat     4080

tttatgttta tgtatttact tttcttttat actttgctca aaatagttat tttcatgtat     4140

gaaactcaat aagcaaggaa ctcacgttat tatataacct aataggaata atttaggtaa     4200

cataatttat catcctcttg atttaaaaga gatatgcctc cagaataaga cacatactaa     4260

aaataactct aatattgaat aactaaagtc gtacaaatct ctactattat tcctataaaa     4320

taataaagaa ctagctacaa cttctttaag gcattattca gggtttacag cttgagaggc     4380

atgaacccat cctgtatact cctggacttg gaagacaaaa tgtcaaccaa agtgaaaggt     4440

tttcttatgg ttgctgctaa gagatagatt gaacactaga tctctcctaa gacgtcaggg     4500

catgcgttta gactcctaca catgcgaaaa ctgcatctta cagttggaag aaactatatc     4560

tcaccacttc ctgcggtgta actttgccca aagatgttgg ctcactgttg gaatcactcc     4620

gccccgaact ttggatctaa cgcttgcagt gctacatatt agagcaagac taacaatgcc     4680

gtggagaatg gaaggtatta taaccatgtc atggtgcata tggaaatgtc gaaataactg     4740

gatattcgaa aacataccgc caacggtggc ggcctgcaag gaaatgttca agactgaaat     4800

gaactacatc tgctaccaag ttaagctcga gacaggagct aaaagtagaa actggataca     4860

acactttgta acatagtgac actccccttt tcctttcttt taccttagaa ctatacatac     4920

aatccacatt caataaaaat ttgtaggtac gccatacaca ctaccggaat ccggctcttt     4980

gccgagtgtg aggcgctttg tcgagtgctt tttgtccagc actcggcaaa aaagtctttg     5040

ccatgtgccg cactcggcaa agtcctgctc tcggtaacga ccgcgtttac cgagagcagg     5100

actctcgaca cagaaataca ctcgacaaag aaatctttgc cgagagccaa acactcggcg     5160

aacggcagcg ctcggcaaag ggtcgtcagc cgccgtctaa agctgacggt cgttatcttt     5220

gtcgagtgcc ccctcgtccg acactcagta gagcaagctt gccgagtgcc atccttggac     5280

actcgataaa gtatatttta ttttttttta ttttgccaac caaacttttt gtggtatgtt     5340

cctacactat gtagatctac atgtaccatt ttggcacaat tacaaaaatg ttttctataa     5400

ctattagatt tagttcgttt atttgaattt cttcggaaaa ttcacatatg aactgcaagt     5460

cactcgaaac atgaaaaacc gtgcatgcaa aataaatgat atgcatgtta tctagcacaa     5520

gttacgaccg aattcagaag cagaccagaa tcttcaagca ccatgctcac taaacatgac     5580

cgtgaacttg ttatccagtt gtttaaaaat tgtataaaac acaaataaag tcagaaatta     5640

atgaaacttg tccacatgtc atgatatcat atatagaggt tgtgataaaa atttgataat     5700

gtttcggtaa agttgtgacg tactatgtgt agaaacctaa gtgacctaca cataaaatca     5760

tagagtttca atgtagttca ctcgacaaag actttgtcaa gtgtccgata aaaagtattc     5820

agcaaagaag ccgttgtcga tttactgttc gtcgagatct ctttgccgag tgtcacacta     5880

ggcaaagtct ttacggagtg tttttcaggc tttgacactc ggcaaagcgc tcgattccag     5940

tagtgacagt aatttgcatc aaaaatagcc gagagattta aaatgagtca actaatagac     6000

caactaatta ttagctatta gtcgttagct tctttaatct aagctaaaac caactaatag     6060

cttatttgtt gaattacaat tagctcaacg gaattctctg ttttttctat aaaaaaaagg     6120

gaaactgccc ctcatttaca gcaaactgtc cgctgcctgt cgtccagata caatgaacgt     6180

acctagtagg aactctttta cacgctcggt cgctcgccgc ggatcggagt cccaggaaca     6240

cgacaccact gtggaacacg acaaagtctg ctcagaggcg gccacaccct ggcgtgcacc     6300

gagccggagc ccggataagc acggtaagga gagtacggcg ggacgtggcg acccgtgtgt     6360

ctgctgccac gcagccttcc tccacgtagc cgcgcggccg cgccacgtac cagggcccgg     6420

cgctggtata aatgcgcgcc acctccgctt tagttctgca tacagccaac ccaacacaca     6480

cccgagcata tcacagtgac agacactaca                                      6510


<210>  19
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Endoplasmic reticulum signal sequence

<400>  19
aaggacgagc tc                                                           12


<210>  20
<211>  28038
<212>  DNA
<213>  Porcine epidemic diarrhea virus

<400>  20
acttaaaaag attttctatc tacggatagt tagctctttt tctagactct tgtctactca       60

attcaactaa acgaaatttt gtccttccgg ccgcatgtcc atgctgctgg aagctgacgt      120

ggaatttcat taggtttgct taagtagcca tcgcaagtgc tgtgctgtcc tctagttcct      180

ggttggcgtt ccgtcgcctt ctacatacta gacaaacagc cttcctccgg ttccgtctgg      240

gggttgtgtg gataactagt tccgtctagt ttgaaactag taactgtcgg ctatggctag      300

caaccatgtt acattggctt ttgccaatga tgcagaaatt tcagcttttg gcttttgcac      360

tgctagtgaa gccgtctcat actattctga ggccgccgct agtggattta tgcaatgccg      420

tttcgtgtcc ttcgatctcg ctgacactgt tgagggattg cttcccgaag actatgtcat      480

ggtggtggtc ggcactacca agcttagtgc gtatgtggac acttttggta gccgccccaa      540

aaacatttgt ggttggctgt tattttctaa ctgtaattac ttcctcgaag agttagagct      600

tacttttggt cgtcgtggtg gtaacatcgt gccagttgac caatacatgt gtggcgctga      660

cggtaaacct gttcttcagg aatccgaatg ggagtataca gatttctttg ctgactccga      720

agacggtcaa ctcaacattg ctggtatcac ttatgtgaag gcctggattg tagagcgatc      780

ggatgtctct tatgcgagtc agaatttaac atctattaag tctattactt actgttcaac      840

ctatgagcat acttttcctg atggtactgc catgaaggtt gcacgtactc caaagattaa      900

gaagactgtt gtcttgtctg agccacttgc tactatctac agggaaattg gttctccttt      960

tgtggataat gggagcgatg ctcgttctat cattaagaga ccagtgttcc tccacgcttt     1020

tgttaagtgt aagtgtggta gttatcattg gactgttggt gattggactt cctatgtctc     1080

cacttgctgt ggctttaagt gtaagccagt ccttgtggct tcatgctctg ctacgcctgg     1140

ttctgttgtg gttacgcgcg ctggtgctgg cactggtgtt aagtattaca acaacatgtt     1200

cctgcgccat gtggcagaca ttgatgggtt ggcattctgg cgaattctca aggtgcagtc     1260

caaagacgac ctcgcttgct ctggtaaatt ccttgaacac catgaggaag gtttcacaga     1320

tccttgctac tttttgaatg actcgagcat tgctactaag ctcaagtttg acatccttag     1380

tggcaagttt tctgatgaag tcaaacaagc tatctttgct ggtcatgttg ttgttggcag     1440

cgcgctcgtt gacattgttg acgatgcact gggacagcct tggtttatac gtaagcttgg     1500

tgaccttgca agtgcagctt gggagcagct taaggctgtc gttagaggcc ttaacctcct     1560

gtctgatgag gtcgtgctct ttggcaaaag acttagctgt gccactctta gtatcgttaa     1620

cggtgttttt gagttcatcg ccgaagtgcc tgagaagttg gctgcggctg ttacagtttt     1680

tgtcaacttc ttgaatgagc tttttgagtc tgcctgtgac tgcttaaagg tcggaggtaa     1740

aacctttaac aaggttggct cttatgttct ttttgacaac gcattggtta agcttgtcaa     1800

ggcaaaagtt cgcggcccac gacaggcagg tgtttgtgaa gttcgttaca caagccttgt     1860

tattgggagt actaccaagg tggtttccaa gcgcgttgaa aatgccaatg tgaatctcgt     1920

cgtcgttgac gaggatgtga ccctcaacac cactggtcgt acagttgttg ttgacggact     1980

tgcattcttc gagagtgacg ggttttacag acatcttgct gatgctgacg ttgtcattga     2040

acatcctgtt tataagtctg cttgtgagct caagccagtt tttgagtgtg acccaatacc     2100

tgattttcct atgcctgtgg ccgctagtgt tgcagagctt tgtgtgcaaa ctgatctgtt     2160

gcttaaaaat tacaacactc cttataaaac ttacagctgc gttgtgagag gtgataagtg     2220

ttgtatcact tgcaccttac atttcacagc accaagttat atggaggctg ctgctaattt     2280

tgtagacctc tgtaccaaga acattggtac tgctggtttt catgagtttt acattacggc     2340

ccatgaacaa caggatctgc aagggttcgt aaccacttgt tgcacgatgt caggttttga     2400

gtgttttatg cctataatcc cacagtgtcc agcagtgctt gaagagattg atggtggtag     2460

catctggcgg tcttttatca ctggtcttaa tacaatgtgg gatttttgca agcatcttaa     2520

agtcagcttt ggactagatg gcattgttgt cactgtagca cgcaaattta aacgacttgg     2580

tgctctcttg gcagaaatgt ataacactta cctttcaact gtggtggaaa acttggtact     2640

ggccggtgtt agcttcaagt attatgccac cagtgtccca aaaattgttt tgggctgttg     2700

ttttcacagt gttaaaagtg ttcttgcaag tgccttccag attcctgtcc aggcaggcgt     2760

tgagaagttt aaagtcttcc ttaactgtgt tcaccctgtt gtaccacgtg tcattgaaac     2820

ttcttttgtg gaattagaag agacgacatt taaaccacca gcactcaatg gtagtattgc     2880

tattgttgat ggctttgctt tctattatga tggaacacta tactatccca ccgatggtaa     2940

tagcgttgtt cctatctgct ttaagaagaa aggtggtggt gatgtcaaat tctctgatga     3000

agtctctgtt aaaaccattg acccagttta taaggtctcc cttgaatttg agttcgagtc     3060

tgagactatt atggctgtgc ttaataaggc tgttggtaat tgtatcaagg ttacaggtgg     3120

ttgggacgat gttgttgagt atatcaatgt tgccattgag gttcttaaag atcacatcga     3180

tgtgcctaag tactacatct atgatgagga aggtggcacc gatcctaatc tgcccgtaat     3240

ggtttctcag tggccgttga atgatgacac gatctcacag gatctgcttg atgttgaagt     3300

tgttactgat gcgccagttg atttcgaggg tgatgaagta gactcctctg accctgataa     3360

ggtggcagac gtggctaact ctgagcctga ggatgacggt cttaatgtag ctcctgaaac     3420

aaatgtagag tctgaagttg aggaagttgc cgcaaccttg tcctttatta aagatacacc     3480

ttccacagtt actaaggatc cttttgcttt tgactttgca agctatggag gacttaaggt     3540

tttaagacaa tctcataaca actgctgggt tacttctacc ttggtgcagc tacaattgct     3600

tggcatcgtt gatgaccctg caatggagct ttttagtgct ggtagagttg gtccaatggt     3660

tcgcaaatgc tatgagtcac aaaaggctat cttgggatct ttgggtgatg tgtcggcttg     3720

cctagagtct ctgactaagg acctacacac acttaagatt acctgttctg tagtctgtgg     3780

ttgtggtact ggtgaacgta tctatgatgg ttgtgctttt cgtatgacgc caactttgga     3840

accgttccca tatggtgctt gtgctcagtg tgctcaagtt ttgatgcaca cttttaaaag     3900

tattgttggc accggcatct tttgtcgaga tactactgct ctctccttgg attctttggt     3960

tgtaaaacct ctttgtgcgg ctgcttttat aggcaaggat agtggtcatt atgtcactaa     4020

cttttatgat gctgctatgg ctattgatgg ttatggtcgt catcagataa agtatgacac     4080

actgaacact atttgtgtta aagacgttaa ttggacagca ccttttgtcc cagacgttga     4140

gcctgtattg gagcctgttg tcaaaccttt ctattcttat aagaatgttg atttttacca     4200

aggagatttt agtgaccttg ttaaacttcc atgtgatttt gttgttaatg ctgcaaatga     4260

gaatttgtct cacggtggcg gcatagcaaa ggccattgat gtttatacca agggcatgtt     4320

gcagaagtgc tcgaatgatt acattaaagc acacggtccc attaaagttg gacgtggtgt     4380

catgttggag gcattaggtc ttaaggtctt taatgttgtt ggtccacgta agggtaagca     4440

tgcacctgag cttcttgtta aggcttataa gtccgttttt gctaattcag gtgttgctct     4500

tacacctttg attagtgttg gaatttttag tgttcctttg gaagaatctt tatctgcttt     4560

tcttgcatgt gttggtgatc gccactgtaa gtgcttttgt tatagtgaca aagagcgcga     4620

ggcgatcatt aattacatgg atggcttggt agatgctatt ttcaaagatg cacttgttga     4680

tactactcct gtccaggaag atgttcaaca agtttcacaa aaaccagttt tgcctaattt     4740

tgaacctttc aggattgaag gtgctcatgc tttctatgag tgcaaccctg aaggtttgat     4800

gtcattaggt gctgacaagc tggtgttgtt tacaaattcc aatttggatt tttgtagcgt     4860

tggtaagtgt cttaacaatg tgactggcgg tgcattgctt gaagccataa atgtatttaa     4920

aaagagtaac aaaacagtgc ctgctggcaa ctgtgttact tttgagtgtg cagatatgat     4980

ttctattact atggtagtat tgccatctga cggtgatgct aattatgaca aaaattatgc     5040

acgcgccgtc gtcaaggtat ctaagcttaa aggcaagtta ttgcttgctg ttggtgatgc     5100

catgttgtat tccaagttgt cccacctcag cgtgttaggt ttcgtatcca cacctgatga     5160

tgtggagcgt ttctacgcaa ataagagtgt ggttattaaa gttactgagg atacacgtag     5220

tgttaagact gttaaagtag aatccactgt tacttatgga caacaaattg gaccttgtct     5280

tgttaatgac accgttgtca cagacaacaa acctgttgtt gctgatgttg tagctaaggt     5340

tgtaccaagt gctaattggg attcacatta tggttttgat aaggctggtg agttccacat     5400

gctagaccat actgggtttg cctttcctag tgaagttgtt aacggtaggc gtgtgcttaa     5460

aaccacagat aataactgtt gggttaatgt tacatgttta caattacagt ttgctagatt     5520

taggttcaag tcagcaggtc tacaggctat gtgggagtcc tattgtactg gtgatgttgc     5580

tatgtttgtg cattggttgt actggcttac tggtgttgac aaaggtcagc ctagtgattc     5640

agaaaatgca cttaacatgt tgtctaagta cattgttcct gctggttctg tcactattga     5700

acgtgtcacg catgacggtt gttgttgtag taagcgtgtt gtcactgcac cagttgtgaa     5760

tgctagcgtg ttgaagcttg gcgtcgagga tggtctttgt ccacatggtc ttaactacat     5820

tgacaaagtt gttgtagtta aaggtactac aattgttgtc aatgttggaa aacctgtagt     5880

ggcaccatcg cacctctttc ttaagggtgt ttcctacaca acattcctag ataatggtaa     5940

cggtgttgcc ggccattata ctgtttttga tcatgacact ggtatggtgc atgatggaga     6000

tgtttttgta ccaggtgatc tcaatgtgtc tcctgttaca aatgttgtcg tctcagagca     6060

gacggctgtt gtgattaaag accctgtgaa gaaagtagag ttagacgcta caaagctgtt     6120

agacactatg aattatgcat cggaaagatt cttttccttt ggtgatttta tgtcacgtaa     6180

tttaattaca gtgtttttgt acatccttag tattttgggt ctctgtttta gggcctttcg     6240

taagagggat gttaaagttc tagctggtgt accccaacgt actggtatta tattgcgtaa     6300

aagtgtgcgc tataatgcaa aggctttggg tgtcttcttc aagctaaaac tttattggtt     6360

caaagttctt ggtaagttta gtttgggtat ttatgcattg tatgcattac tattcatgac     6420

aatacgcttt acacctatag gtggccctgt ttgtgatgat gttgttgctg gttatgctaa     6480

ttctagtttt gacaagaatg agtattgcaa cagtgttatt tgtaaggtct gtctctatgg     6540

gtaccaggaa ctttcggact tctctcacac acaggtagta tggcaacacc ttagagaccc     6600

attaattggt aatgtgatgc ctttctttta tttggcattt ctggcaattt ttgggggtgt     6660

ttatgtaaag gctattactc tctattttat tttccagtat cttaacatac ttggtgtgtt     6720

tttgggccta caacagtcca tttggttttt gcagcttgtg ccttttgatg tctttggtga     6780

cgagatcgtc gtctttttca tcgttacacg cgtattgatg ttccttaagc atgttttcct     6840

tggctgcgat aaggcatctt gtgtggcttg ctctaagagt gctcgcctta agcgcgttcc     6900

tgtccagact atttttcagg gtactagcaa atccttctac gtacatgcca atggtggttc     6960

taagttctgt aagaagcaca atttcttttg tttaaattgt gattcttatg gtccaggctg     7020

cacttttatt aatgacgtca ttgcaactga agttggtaat gttgtcaaac ttaatgtgca     7080

accgacaggt cctgccacta ttcttattga caaggttgaa ttcagtaatg gtttttacta     7140

tctttatagt ggtgacacat tttggaagta caactttgac ataacagata acaaatacac     7200

ttgcaaagag tcacttaaaa attgtagcat aatcacagac tttattgttt ttaacaataa     7260

tggttccaat gtaaatcagg ttaagaatgc atgtgtgtat ttttcacaga tgctttgtaa     7320

acctgttaag ttagtggact cagcgttgtt ggccagtttg tctgttgatt ttggtgcaag     7380

cttacatagt gcttttgtta gtgtgttgtc gaatagtttt ggcaaagacc tgtcaagttg     7440

taatgacatg caggattgca agagcacatt gggttttgat gatgtaccat tggatacctt     7500

taatgctgct gttgctgagg ctcatcgtta cgatgtcctc ttgactgaca tgtcgttcaa     7560

caattttacc accagttatg caaaaccaga ggaaaaactt cccgtccatg acattgccac     7620

gtgtatgcgt gtaggtgcca agattgttaa tcataacgtt cttgtcaagg atagtatacc     7680

tgtggtgtgg cttgtacgtg atttcattgc cctttctgaa gaaactagga agtacattat     7740

tcgtacgact aaagttaagg gtataacctt catgttgacc tttaatgatt gtcgtatgca     7800

tactaccata cctactgttt gcattgcaaa taagaagggt gcaggtcttc ctagtttttc     7860

aaaggttaag aaattcttct ggtttttgtg tctgttcata gttgctgttt tctttgcact     7920

aagctttttt gattttagta ctcaggttag cagtgatagt gattatgact tcaagtatat     7980

tgagagtggc cagttgaaga cttttgacaa tccacttagt tgtgtgcata atgtctttag     8040

taacttcgac cagtggcatg atgccaagtt tggtttcacc cccgtcaaca atcctagttg     8100

tcctatagtc gttggtgtat cagacgaagc gcgcactgtt ccaggtatcc cagcaggtgt     8160

ttatttagct ggtaaaacac ttgtttttgc tattaacacc atttttggta catctggttt     8220

gtgctttgat gctagtggcg ttgctgataa gggcgcttgc atttttaatt cggcttgcac     8280

cacattatct ggtttgggtg gaactgctgt ctactgttat aagaatggtc tagttgaagg     8340

tgctaaactt tatagtgagt tggcacctca tagctactat aaaatggtag atggtaatgc     8400

tgtgtcttta cctgaaatta tctcacgcgg ctttggcatc cgtactatcc gtacaaaggc     8460

tatgacctac tgtcgcgttg gccagtgtgt gcaatctgca gaaggtgttt gttttggcgc     8520

cgatagattc tttgtctata atgcagaatc tggttctgac tttgtttgtg gcacagggct     8580

ctttacattg ttgatgaacg ttattagtgt tttttccaag acagtaccag taactgtgtt     8640

gtctggtcaa atacttttta attgcattat tgcttttgct gctgttgcgg tgtgtttctt     8700

atttacaaag tttaagcgca tgttcggtga tatgtctgtt ggcgttttca ctgtcggtgc     8760

ttgtactttg ttgaacaatg tttcctacat tgtaacacag aacacacttg gcatgttggg     8820

ctatgcaact ttgtactttt tgtgcactaa aggtgttaga tatatgtgga tttggcattt     8880

gggatttttg atctcatata tacttattgc accatggtgg gttttgatgg tttatgcctt     8940

ttcagccatt tttgagttta tgcctaacct ttttaagctt aaggtttcaa cacaactttt     9000

tgagggtgac aagttcgtag gctcttttga aaatgctgca gcaggtacat ttgtgcttga     9060

tatgcatgcc tatgagagac ttgccaactc tatctcaact gaaaaactgc gtcagtatgc     9120

tagtacttac aataagtaca agtattattc aggcagtgct tcagaggctg attacaggct     9180

tgcttgtttt gcccatttgg ccaaggctat gatggattat gcttctaatc acaacgacac     9240

gttatacaca ccacccactg tgagttacaa ttcaactcta caggctggct tgcgtaagat     9300

ggcacaacca tctggtgttg ttgagaagtg catagttcgt gtttgctatg gtaatatggc     9360

tcttaatggc ctatggcttg gtgatactgt tatctgccca cgccatgtta tagcgtctag     9420

tactactagc actatagatt atgactatgc cctttctgtt ttacgcctcc acaacttctc     9480

catttcatct ggtaatgttt tcctaggtgt tgtgggtgta accatgcgag gtgctttgtt     9540

gcagataaag gttaatcaaa acaatgtcca cacgcctaag tacacctatc gcacagttag     9600

accgggtgaa tcttttaata tcttggcgtg ctatgatggt tctgcagctg gtgtttacgg     9660

cgttaacatg cgctctaatt acactattag aggctcgttc attaatggcg cttgtggttc     9720

acctggttat aacattaaca atggtaccgt tgagttttgc tatttacacc agcttgaact     9780

tggttcaggc tgtcatgttg gtagcgactt agatggtgtt atgtatggtg gttatgagga     9840

ccaacctact ttgcaagttg aaggcgctag tagtctgttt acagagaatg tgttggcatt     9900

tctttatgca gcactcatta atggttctac ctggtggctt agttcttcta ggattgctgt     9960

agacaggttt aatgagtggg ctgttcataa tggtatgaca acagtagtta atactgattg    10020

cttttctatt cttgctgcta agactggtgt tgatgtacaa cgtttgttgg cctcaatcca    10080

gtctctgcat aagaattttg gtggaaagca aattcttggc tatacctcgt tgacagatga    10140

gtttactaca ggtgaagtta tacgtcaaat gtatggcgtt aatcttcaga gtggttatgt    10200

ttcacgcgcc tgtagaaatg tcttgctggt tggttctttt ctgactttct tttggtcaga    10260

attagtttcc tacactaagt tcttttgggt aaatcctggt tatgtcacac ctatgtttgc    10320

gtgtttgtca ttgctgtcct cacttttgat gttcacactc aagcataaga cattgttttt    10380

ccaggtcttt ctaatacctg ctctgattgt tacatcttgc attaatttgg catttgatgt    10440

tgaagtctac aactatttgg cagagcattt tgattaccat gtttctctca tgggttttaa    10500

tgcacaaggt cttgttaaca tctttgtctg ctttgttgtt accattttac acggcacata    10560

cacatggcgc ttttttaaca cacctgtgag ttctgtcact tatgtggtag ctttgctgac    10620

tgcggcatat aactattttt acgctagtga cattcttagt tgtgctatga cactatttgc    10680

tagtgtgact ggcaactggt tcgttggtgc tgtttgttat aaagctgctg tttatatggc    10740

cttgagattt cctacttttg tggctatttt tggtgatatt aagagtgtta tgttctgtta    10800

ccttgtgttg ggttatttta cctgttgctt ctacggtatt ctctactggt tcaacaggtt    10860

ttttaaggtt agtgtaggtg tctatgacta tactgttagt gctgctgagt ttaagtatat    10920

ggttgctaac ggcctacgtg caccaactgg aacacttgat tcactacttc tgtctgccaa    10980

attgattggt attggtggtg agcggaatat taagatttct tccgttcagt ctaaactgac    11040

tgatattaag tgtagtaacg ttgtgctttt aggctgtctc tctagcatga atgtctcagc    11100

aaattcaaca gaatgggcct attgtgttga cttgcataac aagatcaact tgtgtaatga    11160

cccagaaaaa gcgcaggaaa tgctacttgc tttgttggca tttttcctta gtaagaatag    11220

tgcttttggt ttagatgact tattggaatc ctattttaat gacaatagta tgttgcagag    11280

tgttgcatct acttatgtcg gtttgccttc ttatgtcatt tatgaaaatg cacgccaaca    11340

gtatgaagat gctgttaata atggttctcc acctcagttg gttaagcaat tgcgccatgc    11400

catgaatgta gcaaagagcg aatttgaccg tgaggcttct actcagcgta agcttgatag    11460

aatggcggaa caggctgcag cacagatgta caaagaggca cgagcagtta ataggaagtc    11520

caaagttgta agtgctatgc attcactgct ttttggtatg ttgagacgtt tggacatgtc    11580

ttctgtagac accattctca acttggcaaa ggatggggtt gtacctctgt ctgtcatacc    11640

ggcagtcagt gctactaagc ttaacattgt tacttctgat atcgattctt ataatcgtat    11700

ccagcgtgag ggatgtgtcc actacgctgg taccatttgg aatataattg atatcaagga    11760

caatgatggc aaggtggtac acgttaagga ggtaaccgca cagaatgctg agtccctgtc    11820

atggcccctg gtccttgggt gtgagcgtat tgtcaagctc cagaataatg aaattattcc    11880

tggtaagctg aagcagcgct ccattaaggc agaaggagat ggcatagttg gagaaggtaa    11940

ggcactttac aataatgagg gtggacgtac ttttatgtat gctttcatct cggacaaacc    12000

ggacctgcgt gtagtcaagt gggagttcga tggtggttgt aacactattg agctagaacc    12060

accacgtaag ttcttggtgg attctcctaa tggtgcacag atcaagtatc tctactttgt    12120

tcgtaacctt aacacgttac gtaggggtgc tgttctcggc tacataggtg ccactgtacg    12180

cttgcaggct ggtaaacaaa cagaacaggc tattaactct tcattgttga cactttgcgc    12240

tttcgctgtg gatcctgcta agacctacat cgatgctgtc aaaagtggtc acaaaccagt    12300

aggtaactgt gttaagatgt tggccaatgg ttctggtaat ggacaagctg ttactaatgg    12360

tgtggaggct agtactaacc aggattcata cggtggtgcg tccgtgtgtc tatattgtag    12420

agcacatgtt gagcatccat ctatggatgg tttttgcaga ctgaaaggca agtacgtaca    12480

ggttccacta ggtacagtgg atcctatacg ttttgtactt gagaatgacg tttgcaaggt    12540

ttgtggttgt tggctggcta atggctgcac ttgtgacaga tccattatgc aaagcactga    12600

tatggcttat ttaaacgagt acggggctct agtgcagctc gactagagcc mtgtaacggt    12660

actgatacac aacatgtgta tcgtgctttt gacatctaca acaaggatgt tgcttgtcta    12720

ggtaaattcc tcaaggtgaa ctgtgttcgc ctgaagaatt tggataagca tgatgcattc    12780

tatgttgtca aaagatgtac caagtctgcg atggaacacg agcaatccat ctatagcaga    12840

cttgaaaagt gtggagccgt agccgaacac gatttcttca cttggaagga tggtcgtgcc    12900

atctatggta acgtttgtag aaaggatctt accgagtata ctatgatgga tttgtgttac    12960

gctttacgta actttgatga aaacaattgc gatgttctta agagcatttt aattaaggta    13020

ggcgcttgtg aggagtccta cttcaataat aaagtctggt ttgaccctgt tgaaaatgaa    13080

gacattcatc gtgtctatgc attgttaggt accattgttt cacgtgctat gcttaaatgc    13140

gttaagttct gtgatgcaat ggttgaacaa ggtatagttg gtgttgtcac attagataat    13200

caggatctta atggtgattt ttatgatttt ggtgatttta cttgtagcat caagggaatg    13260

ggtataccca tttgcacatc atattactct tatatgatgc ctgttatggg tatgactaat    13320

tgccttgcta gtgagtgttt tgttaagagt gatatatttg gtgaggattt caagtcatat    13380

gacctgctgg aatatgattt cacggagcat aagacagcac tcttcaacaa gtatttcaag    13440

tattggggac tgcaatacca ccctaactgt gtggactgca gtgatgagca gtgcatagtt    13500

cactgtgcca acttcaatac gttgttttcc actactatac ctattacggc atttggacct    13560

ttgtgtcgca agtgttggat tgatggtgtt ccactggtaa ctacagctgg ttatcatttt    13620

aaacagttag gtatagtttg gaacaatgac ctcaacttac actctagcag gctctctatt    13680

aacgaattac tccagttttg tagtgatcct gcattgctta tagcatcatc accagccctt    13740

gttgatcagc gtactgtttg cttttcagtt gcagcgctag gtacaggtat gactaaccag    13800

actgttaaac ctggccattt caataaggag ttttatgact tcttacttga gcaaggtttc    13860

ttttctgagg gctctgagct tactttaaag cacttcttct ttgcacagaa gggtgatgca    13920

gctgttaagg attttgacta ctataggtat aatagaccta ctgttctgga catttgccaa    13980

gctcgcgtcg tgtatcaaat agtgcaacgc tattttgata tttacgaagg tggttgtatc    14040

actgctaaag aggtggttgt tacaaacctt aacaagagcg caggttatcc tttgaacaag    14100

tttggtaaag ctggtcttta ctatgagtct ttatcctatg aggaacagga tgaactttat    14160

gcttatacta agcgtaacat cctgcccact atgacacagc tcaaccttaa atatgctata    14220

agtggcaaag aacgtgcacg cacagtgggt ggtgtttcgc ttttgtcaac catgactact    14280

cggcagtatc atcagaaaca ccttaagtcc atagttaata ctaggggcgc ttcggttgtt    14340

attggtacta ctaagtttta tggtggttgg gacaatatgc ttaagaacct tattgatggt    14400

gttgaaaatc cgtgtcttat gggttgggac tacccaaagt gcgacagagc actgcccaat    14460

atgatacgta tgatttcagc catgatttta ggctctaagc acaccacatg ctgcagttcc    14520

actgaccgct ttttcaggtt gtgcaatgaa ttggctcaag tccttactga ggttgtttat    14580

tctaatggag gtttttattt gaagccaggt ggtactacct ctggtgatgc aaccaccgca    14640

tatgcaaact cagtttttaa tatcttccaa gcagtaagtg ccaatgttaa caaacttctt    14700

agtgttgaca gcaatgtctg tcataattta gaagttaagc aattgcagcg taagctttat    14760

gagtgctgtt atagatcaac taccgtcgat gaccagttcg tcgttgagta ttatggttac    14820

ttgcgtaaac atttttcaat gatgattctt tctgatgatg gcgttgtttg ttataacaat    14880

gactatgcat cacttggtta tgtcgctgat cttaacgcat tcaaggctgt tttgtattac    14940

cagaacaatg tcttcatgag cgcctctaaa tgttggatcg agcctgacat taataaaggt    15000

cctcatgaat tttgctcgca gcatactatg cagattgtcg ataaagatgg tacttattac    15060

cttccttacc ctgatccttc aagaattctc tctgcaggtg tgtttgttga tgacgttgtt    15120

aaaactgatg cagttgtatt gcttgaacgt tatgtgtcat tggctataga tgcctacccg    15180

ttatctaagc atgaaaaccc tgaatataag aaggtgtttt atgtgctttt ggattgggtt    15240

aagcatctgt acaaaactct taatgctggt gtgttagagt ctttttctgt cacacttttg    15300

gaagattcta ctgctaaatt ctgggatgag agcttttatg ccaacatgta tgagaaatct    15360

gcagttttac aatctgcagg gctttgtgtt gtttgtggct ctcaaactgt tttacgttgt    15420

ggtgattgtc tacggcgtcc tatgctttgt actaagtgtg cttatgatca tgtcattgga    15480

acaactcaca agttcatttt ggccatcact ccatatgtgt gttgtgcttc agattgtggt    15540

gtcaatgatg taactaagct ctacttaggt ggtcttagtt attggtgtca tgaccacaag    15600

ccacgtcttg cattcccgtt gtgctctgct ggtaatgttt ttggcttgta caaaaattct    15660

gctaccggct cacccgatgt tgaagacttt aatcgcattg ctacatccga ttggactgat    15720

gtttctgact acaggttggc aaatgatgtc aaggactcat tgcgtctgtt tgcagcggaa    15780

actatcaagg ccaaggagga gagcgttaag tcatcctatg cttgtgcaac actacatgag    15840

gttgtaggac ctaaagagtt gttgctcaaa tgggaagtcg gcagacccaa accacccctt    15900

aatagaaatt cggttttcac ttgttatcat ataacgaaga acaccaaatt tcaaatcggt    15960

gagtttgtgt ttgagaaggc agaatatgat aatgatgctg taacatataa aactaccgcc    16020

acaacaaaac ttgttcctgg catggttttt gtgcttacct cacataatgt tcagccattg    16080

cgcgcaccga ccattgctaa tcaagaacgt tattccacta tacataagtt gcatcctgct    16140

tttaacatac ctgaagctta ttctagctta gtgccctatt accaattgat tggtaagcag    16200

aagattacaa ctattcaggg acctcccggt agtggtaaat ctcactgtgt tatagggcta    16260

ggtttgtact atccaggtgc acgtatagtg tttacagctt gttctcatgc agcggtcgat    16320

tcactttgtg tgaaagcttc cactgcttat agcaatgaca aatgttcacg catcatacca    16380

cagcgcgctc gtgttgagtg ttatgatggt ttcaagtcta ataatactag tgctcagtac    16440

cttttctcta ctgtcaatgc tttgccagag tgcaatgcgg acattgttgt ggtggatgag    16500

gtctctatgt gcactaatta tgacttgtct gtcataaatc agcgcatcag ctataggcat    16560

gtagtctatg ttggtgaccc tcaacagctg cctgcaccac gtgttatgat ttcacgtggt    16620

actttggaac caaaggacta caacgttgtc actcaacgca tgtgtgccct taagcctgat    16680

gttttcttgc acaagtgtta tcgctgtcct gctgagatag tgcgtactgt gtctgagatg    16740

gtctatgaaa accaattcat tcctgtgcac ccagatagca agcagtgttt taaaatcttt    16800

tgcaagggta atgttcaggt tgataatggt tcaagcatta atcgcaggca attggatgtt    16860

gtgcgtatgt ttttggctaa aaatcctagg tggtcaaagg ctgtttttat ttctccttat    16920

aacagccaga attatgttgc cagccgcatg ctaggtctac aaattcagac agttgactca    16980

tcccagggta gtgagtatga ctatgtcatt tacacacaaa cttcagatac tgcccatgcc    17040

tgtaatgtta acaggtttaa tgttgccatc acaagggcca agaaaggcat attatgtata    17100

atgtgcgata ggtccctttt tgatgtgctt aaattctttg agcttaaatt gtctgatttg    17160

caggctaatg agggttgtgg tctttttaaa gactgtagca gaggtgatga tctgttgcca    17220

ccatctcacg ctaacacctt catgtcttta gcggacaatt ttaagactga tcaagatctt    17280

gctgttcaaa taggtgttaa tggacccatt aaatatgagc atgttatctc gtttatgggt    17340

ttccgttttg atatcaacat acccaaccat catactctct tttgcacacg cgactttgcc    17400

atgcgcaatg ttagaggttg gttaggcttt gacgttgaag gagcacatgt tgttggctct    17460

aacgtcggta caaatgtccc attgcaatta gggttttcta acggtgttga ttttgttgtc    17520

agacctgaag gttgcgttgt aacagagtct ggtgactaca ttaaacccgt cagagctcgt    17580

gctccaccag gggaacaatt cgcacacctt ttgcctttac ttaaacgcgg ccaaccatgg    17640

gatgttgtcc gcaaacgtat agtgcagatg tgtagtgact acctggccaa cctatcagac    17700

atactaattt ttgtgttgtg ggctggtggt ttggagttga caactatgcg ttattttgtc    17760

aagattggac caagtaagag ttgtgattgt ggtaaggttg ctacttgtta caatagtgcg    17820

ctgcatacgt actgttgttt caaacatgcc cttggttgtg attatctgta taacccatac    17880

tgtattgata tacagcagtg gggatacaag ggatcactta gccttaacca ccatgagcat    17940

tgtaatgtac atagaaacga gcatgtggct tctggtgatg ccataatgac tcgctgtctg    18000

gccatacatg attgctttgt caagaacgtt gactggtcca tcacataccc atttattggt    18060

aatgaggctg ttattaataa gagcggccga attgtgcaat cacacactat gcggtcagtt    18120

cttaagttat acaatccgaa agccatatat gatattggca atcctaaggg cattagatgt    18180

gccgtaacgg atgctaagtg gttttgcttt gacaagaatc ctactaattc taatgtcaag    18240

acattggagt atgactatat aacacatggc caatttgatg ggttgtgctt gttttggaat    18300

tgcaatgtag acatgtatcc agaattttct gtggtctgtc gttttgatac tcgctgtagg    18360

tcaccactca acttggaggg ttgtaatggt ggttcactgt atgttaataa tcatgcattc    18420

catacaccgg cttttgacaa gcgtgctttt gctaagttga agccaatgcc atttttcttt    18480

tatgatgata ctgagtgtga caagttacag gactccataa actatgttcc tcttagggct    18540

agtaactgca ttactaaatg taatgttggt ggtgctgtct gtagtaagca ttgtgctatg    18600

tatcatagct atgttaatgc ttacaacact tttacgtcgg cgggctttac tatttgggtg    18660

cctacttcgt ttgacaccta taatctgtgg cagacattta gtaacaattt gcaaggtctt    18720

gagaacattg ctttcaatgt cgtaaagaaa ggatcttttg ttggtgccga aggtgaactt    18780

cctgtagctg tggttaatga caaagtgctc gttagagatg gtactgttga tactcttgtt    18840

tttacaaaca agacatcact acccactaac gtagcttttg agttgtatgc caagcgtaag    18900

gtaggactca ccccacccat tacgatccta cgtaacttgg gtgtagtttg tacatctaag    18960

tgtgtcattt gggactatga agccgaacgt ccacttacta cttttacaaa ggatgtttgt    19020

aaatataccg actttgaggg tgacgtctgt acactctttg ataacagcat tgttggttca    19080

ttagagcgat tctccatgac ccaaaatgct gtgcttatgt cacttacagc tgttaaaaag    19140

cttactggca taaagttaac ttatggttat cttaatggtg tcccagttaa cacacatgaa    19200

gataaacctt ttacttggta tatttacact aggaagaacg gcaagttcga ggaccatcct    19260

gatggctatt ttacccaagg tagaacaacc gctgatttta gccctcgtag cgacatggaa    19320

aaggacttcc taagtatgga tatgggtctg tttattaaca agtacggact tgaagattac    19380

ggctttgagc acgttgtgta tggtgatgtt tcaaaaacca cccttggtgg tttgcatcta    19440

ctaatttcgc aggtgcgtct ggcctgtatg ggtgtgctca aaatagacga gtttgtgtct    19500

agtaatgata gcacgttaaa gtcttgtact gttacatatg ctgataaccc tagtagtaag    19560

atggtttgta cgtatatgga tctcctgctt gacgattttg tcagcattct taaatctttg    19620

gatttgggcg ttgtatctaa agttcatgaa gttatggtcg attgtaaaat gtggaggtgg    19680

atgttgtggt gtaaggatca taaactccag acattttatc cgcaacttca ggccagtgaa    19740

tggaagtgtg gttattccat gccttctatt tacaagatac aacgtatgtg tttagaacct    19800

tgcaatctct acaactatgg tgctggtatt aagttacctg atggcattat gtttaacgta    19860

gttaaataca cacagctttg tcaatatctc aatagcacca caatgtgtgt accccatcac    19920

atgcgtgtgc tacatcttgg tgctggctcc gacaagggtg ttgcacctgg cacggctgtc    19980

ttacgacgtt ggttgccact ggatgccatt atagttgaca atgatagtgt ggattacgtt    20040

agcgatgctg attatagtgt tacaggagat tgctctacct tatacctgtc agataagttt    20100

gatttagtta tatctgatat gtatgatggt aagattaaaa gttgtgatgg ggagaacgtg    20160

tctaaagaag gcttctttcc ctatattaat ggtgtcatca ccgaaaagtt ggcacttggt    20220

ggtactgtag ctattaaggt gacggagttt agttggaata agaagttgta tgaactcatt    20280

cagaggtttg agtattggac aatgttctgt accagtgtta acacgtcatc gtcagaggca    20340

ttcttaattg gtgttcacta tttaggtgat tttgcaagtg gcgctgtgat tgacggcaac    20400

actatgcatg ccaattatat cttctggcgt aattccacaa ttatgactat gtcttacaat    20460

agtgtacttg atttaagcaa gttcaattgt aagcataagg ctacagttgt cattaattta    20520

aaagattcat ccattagtga tgttgtgtta ggtttgttga agaatggtaa gttgctagtg    20580

cgtaataatg acgccatttg tggtttttct aatcatttgg tcaacgtaaa caaatgaagt    20640

ctttaaccta cttctggttg ttcttaccag tactttcaac acttagccta ccacaagatg    20700

tcaccaggtg ctcagctaac actaatttta ggcggttctt ttcaaaattt aatgttcagg    20760

cgcctgcagt tgttgtactg ggcggttatc tacctattgg tgaaaaccag ggtgtcaatt    20820

caacttggta ctgtgctggc caacatccaa ctgctagtgg cgttcatggt atctttgtta    20880

gccatattag aggtggtcat ggctttgaga ttggcatttc gcaagagcct tttgacccta    20940

gtggttacca gctttattta cataaggcta ctaacggtaa cactaatgct actgcgcgac    21000

tgcgcatttg ccagtttcct agcattaaaa cattgggccc cactgctaat aatgatgtta    21060

caacaggtcg taattgccta tttaacaaag ccatcccagc tcatatgagt gaacatagtg    21120

ttgtcggcat aacatgggat aatgatcgtg tcactgtctt ttctgacaag atctattatt    21180

tttattttaa aaatgattgg tcccgtgttg cgacaaagtg ttacaacagt ggaggttgtg    21240

ctatgcaata tgtttacgaa cccacctatt acatgcttaa tgttactagt gctggtgagg    21300

atggtatttc ttatcaaccc tgtacagcta attgcattgg ttatgctgcc aatgtatttg    21360

ctactgagcc caatggccac ataccagaag gttttagttt taataattgg tttcttttgt    21420

ccaatgattc cactttggtg catggtaagg tggtttccaa ccaaccattg ttggtcaatt    21480

gtcttttggc cattcctaag atttatggac taggccaatt tttctccttt aatcaaacga    21540

tcgatggtgt ttgtaatgga gctgctgtgc agcgtgcacc agaggctctg aggtttaata    21600

ttaatgacac ctctgtcatt cttgctgaag gctcaattgt acttcatact gctttaggaa    21660

caaatttttc ttttgtttgc agtaattcct caaatcctca cttagccacc ttcgccatac    21720

ctctgggtgc tacccaagta ccttattatt gttttcttaa agtggatact tacaactcca    21780

ctgtttataa atttttggct gttttacctc ctaccgtcag ggaaattgtc atcaccaagt    21840

atggtgatgt ttatgtcaat gggtttggat acttgcatct cggtttgttg gatgctgtca    21900

caattaattt cactggtcat ggcactgacg atgatgtttc tggtttttgg accatagcat    21960

cgactaattt tgttgatgca ctcatcgaag ttcaaggaac cgccattcag cgtattcttt    22020

attgtgatga tcctgttagc caactcaagt gttctcaggt tgcttttgac cttgacgatg    22080

gtttttaccc tatttcttct agaaaccttc tgagtcatga acagccaatt tcttttgtta    22140

ctctgccatc atttaatgat cattcttttg ttaacattac tgtatctgct tcctttggtg    22200

gtcatagtgg tgccaacctt attgcatctg acactactat caatgggttt agttctttct    22260

gtgttgacac tagacaattt accatttcac tgttttataa cgttacaaac agttatggtt    22320

atgtgtctaa atcacaggac agtaattgcc ctttcacctt gcaatctgtt aatgattacc    22380

tgtcttttag caaattttgt gtttccacca gccttttggc tagtgcctgt accatagatc    22440

tttttggtta ccctgagttt ggtagtggtg ttaagtttac gtccctttac tttcaattca    22500

caaagggtga gttgattact ggcacgccta aaccacttga aggtgtcacg gacgtttctt    22560

ttatgactct ggatgtgtgt accaagtata ctatctatgg ctttaaaggt gagggtatca    22620

ttacccttac aaattctagc tttttggcag gtgtttatta cacatctgat tctggacagt    22680

tgttagcctt taagaatgtc actagtggtg ctgtttattc tgttacgcca tgttcttttt    22740

cagagcaggc tgcatatgtt gatgatgata tagtgggtgt tatttctagt ttgtctagct    22800

ccacttttaa cagtactagg gagttgcctg gtttcttcta ccattctaat gatggctcta    22860

attgtacaga gcctgtgttg gtgtatagta acataggtgt ttgtaaatct ggcagtattg    22920

gctacgtccc atctcagtct ggccaagtca agattgcacc cacggttact gggaatatta    22980

gtattcccac caactttagt atgagtatta ggacagaata tttacagctt tacaacacgc    23040

ctgttagtgt tgattgtgcc acatatgttt gtaatggtaa ctctcgttgt aaacaattac    23100

tcacccagta cactgcagca tgtaagacca tagagtcagc attacaactc agcgctaggc    23160

ttgagtctgt tgaagttaac tctatgctta ctatttctga agaggctcta cagttagcta    23220

ccattagttc gtttaatggt gatggatata attttactaa tgtgctgggt gtttctgtgt    23280

atgatcctgc aagtggcagg gtggtacaaa aaaggtcttt tattgaagac ctgcttttta    23340

ataaagtggt tactaatggc cttggtactg ttgatgaaga ctataagcgc tgttctaatg    23400

gtcgctctgt ggcagatcta gtctgtgcac agtattactc tggtgtcatg gtactacctg    23460

gtgttgttga cgctgagaag cttcacatgt atagtgcgtc tctcatcggt ggtatggtgc    23520

taggaggttt tacttctgca gcggcattgc cttttagcta tgctgttcaa gctagactca    23580

attatcttgc tctacagacg gatgttctac agcggaacca gcaattgctt gctgagtctt    23640

ttaactctgc tattggtaat ataacttcag cctttgagag tgttaaagag gctattagtc    23700

aaacttccaa gggtttgaac actgtggctc atgcgcttac taaggttcaa gaggttgtta    23760

actcgcaggg tgcagctttg actcaactta ccgtacagct gcaacacaac ttccaagcca    23820

tttctagttc tattgatgac atttactctc gactggacat tctttcagcc gatgttcagg    23880

ttgaccgtct catcaccggc agattatcag cacttaatgc ttttgttgct caaaccctca    23940

ctaagtatac tgaggttcag gctagcagga agttagcaca gcaaaaggtt aatgagtgcg    24000

ttaaatcgca atctcagcgt tatggttttt gtggtggtga tggcgagcac attttctctc    24060

tggtacaggc agcacctcag ggcctgctgt ttttacatac agtacttgta ccgagtgatt    24120

ttgtagatgt tattgccatc gctggcttat gcgttaacga tgaaattgcc ttgactctac    24180

gtgagcctgg cttagtcttg tttacgcatg aacttcaaaa tcatactgcg acggaatatt    24240

ttgtttcatc gcgacgtatg tttgaaccta gaaaacctac cgttagtgat tttgttcaaa    24300

ttgagagttg tgtggtcacc tatgtcaatt tgactagaga ccaactacca gatgtaatcc    24360

cagattacat cgatgttaac aaaacacttg atgagatttt agcttctctg cccaatagaa    24420

ctggtccaag tcttccttta gatgttttta atgccactta tcttaatctc actggtgaaa    24480

ttgcagattt agagcagcgt tcagagtctc tccgtaatac tacagaggag ctccaaagtc    24540

ttatatataa tatcaacaac acactagttg accttgagtg gctcaaccga gttgagacat    24600

atatcaagtg gccgtggtgg gtttggttga ttattttcat tgttctcatc tttgttgtgt    24660

cattactagt gttctgctgc atttccacgg gttgttgtgg atgctgcggc tgctgctgtg    24720

cttgtttctc aggttgttgt aggggtccta gacttcaacc ttacgaagtt tttgaaaagg    24780

tccacgtgca gtgatgtttc ttggactttt tcaatacacg attgacacag ttgtcaaaga    24840

tgtctcaaag tctgctaact tgtctttgga tgctgtccaa gagttggagc tcaatgtagt    24900

tccaattaga caagcttcaa atgtgacggg ttttcttttc accagtgttt ttatctactt    24960

ctttgcactg tttaaagcgt cttctttgag gcgcaattat attatgttgg cagcgcgttt    25020

tgctgtcatt gttctttatt gcccactttt atattattgt ggtgcatttt tagatgcaac    25080

tattatttgt tgcacactta ttggcaggct ttgtttagtc tgcttttact cctggcgcta    25140

taaaaatgcg ctctttatta tttttaatac tacgacactt tctttcctca atggtaaagc    25200

agcttattat gacggcaaat ccattgtgat tttagaaggt ggtgaccatt acatcacttt    25260

tggcaactct cttgttgctt ttgttagtag catcgacttg tatctagcta tacgtgggcg    25320

gcaagaagct gacctacagc tgttgcgaac tgttgagctt cttgatggca agaagcttta    25380

tgtcttttcg caacatcaaa ttgttggcat tactaatgct gcatttgact caattcaact    25440

agacgagtat gctacaatta gtgaatgata atggtctagt agttaatgtt atactttggc    25500

ttttcgtact ctttttcctg cttattataa gcattacttt cgtccaattg gttaatctgt    25560

gcttcacttg tcaccggttg tgtaatagcg cagtttacac acctataggg cgtttgtata    25620

gagtttataa gtcttacatg caaatagacc ccctccctag tactgttatt gacgtataaa    25680

cgaaatatgt ctaacggttc tattcccgtt gatgaggtga ttcaacacct tagaaactgg    25740

aatttcacat ggaatatcat actgacgata ctacttgtag tgcttcagta tggccattac    25800

aagtactctg cgttcttgta tggtgtcaag atggctattc tatggatact ttggcctctt    25860

gtgttagcac tgtcactttt tgatgcatgg gctagctttc aggtcaattg ggtctttttt    25920

gctttcagca tccttatggc ttgcatcact cttatgctgt ggataatgta ctttgtcaat    25980

agcattcggt tgtggcgcag gacacattct tggtggtctt tcaatcctga aacagacgcg    26040

cttctcacta cttctgtgat gggccgacag gtctgcattc cagtgcttgg agcaccaact    26100

ggtgtaacgc taacactcct tagtggtaca ttgcttgtag agggctataa ggttgctact    26160

ggcgtacagg taagtcaatt acctaatttc gtcacagtcg ccaaggccac tacaacaatt    26220

gtctacggac gtgttggtcg ttcagtcaat gcttcatctg gcactggttg ggctttctat    26280

gtccggtcca aacacggcga ctactcagct gtgagtaatc cgagttcggt tctcacagat    26340

agtgagaaag tgcttcattt agtctaaaca gaaactttat ggcttctgtc agttttcagg    26400

atcgtggccg caaacgggtg ccattatccc tctatgcccc tcttagggtt actaatgaca    26460

aacccctttc taaggtactt gcaaataatg ctgtacccac taataaagga aataaggacc    26520

agcaaattgg atactggaat gagcaaattc gctggcgcat gcgccgtggt gagcgaattg    26580

aacaaccttc caattggcat ttctactacc tcggaacagg acctcacgcc gacctccgct    26640

ataggactcg tactgagggt gttttctggg ttgctaaaga aggcgcaaag actgaaccca    26700

ctaacctggg tgtcagaaag gcgtctgaaa agccaattat tccaaatttc tctcaacagc    26760

ttcccagcgt agttgagatt gttgaaccta acacacctcc tacttcacgt gcaaattcac    26820

gtagcaggag tcgtggtaat ggcaacaaca ggtccagatc tccaagtaac aacagaggca    26880

ataaccagtc ccgcggtaat tcacagaatc gtggaaataa ccagggtcgt ggagcttctc    26940

agaacagagg aggcaataat aataacaata acaagtctcg taaccagtcc aagaacagaa    27000

accagtcaaa tgaccgtggt ggtgtaacat cacgcgatga tctggtggct gctgtcaagg    27060

atgcccttaa atctttgggt attggcgaaa accctgacaa gcttaagcaa cagcagaagc    27120

ccaaacagga aaggtctgac agcagcggca aaaatacacc taagaagaac aaatccagag    27180

ccacttcgaa agaacgtgac ctcaaagaca tcccagagtg gaggagaatt cccaagggcg    27240

aaaatagcgt agcagcttgc ttcggaccca ggggaggctt caaaaatttt ggagatgcgg    27300

aatttgtcga aaaaggtgtt gatgcctcag gctatgctca gatcgccagt ttagcaccaa    27360

atgttgcagc attgctcttt ggtggtaatg tggctgttcg tgagctagcg gactcttacg    27420

agattacata taattataaa atgactgtgc caaagtctga tccaaatgta gagcttcttg    27480

tttcacaggt ggatgcattt aaaactggga atgcaaaacc ccagagaaag aaggaaaaga    27540

agaacaagcg tgaaaccacg cagcagctga atgaagaggc catctacgat gatgtgggtg    27600

tgccatctga tgtgactcat gccaatttgg aatgggacac agctgttgat ggtggtgaca    27660

cggccgttga aattatcaac gagatcttcg acacaggaaa ttaaacaatg tttgactggc    27720

ttatcctggc tatgtcccag ggtagtgcca ttacactgtt attactgagt gtttttctag    27780

cgacttggct gctgggctat ggctttgccc tctaactagc ggtcttggtc ttgcacacaa    27840

cggtaagcca gtggtaatgt cagtgcaaga aggatattac catagcactg tcatgagggg    27900

aacgcagtac cttttcatct aaacctttgc acgagtaatc aaagatccgc ttgacgagcc    27960

tatatggaag agcgtgccag gtatttgact caaggactgt tagtaactga agacctgacg    28020

gtgttgatat ggatacac                                                  28038


<210>  21
<211>  1386
<212>  PRT
<213>  Porcine epidemic diarrhea virus

<400>  21

Met Lys Ser Leu Thr Tyr Phe Trp Leu Phe Leu Pro Val Leu Ser Thr 
1               5                   10                  15      


Leu Ser Leu Pro Gln Asp Val Thr Arg Cys Ser Ala Asn Thr Asn Phe 
            20                  25                  30          


Arg Arg Phe Phe Ser Lys Phe Asn Val Gln Ala Pro Ala Val Val Val 
        35                  40                  45              


Leu Gly Gly Tyr Leu Pro Ile Gly Glu Asn Gln Gly Val Asn Ser Thr 
    50                  55                  60                  


Trp Tyr Cys Ala Gly Gln His Pro Thr Ala Ser Gly Val His Gly Ile 
65                  70                  75                  80  


Phe Val Ser His Ile Arg Gly Gly His Gly Phe Glu Ile Gly Ile Ser 
                85                  90                  95      


Gln Glu Pro Phe Asp Pro Ser Gly Tyr Gln Leu Tyr Leu His Lys Ala 
            100                 105                 110         


Thr Asn Gly Asn Thr Asn Ala Thr Ala Arg Leu Arg Ile Cys Gln Phe 
        115                 120                 125             


Pro Ser Ile Lys Thr Leu Gly Pro Thr Ala Asn Asn Asp Val Thr Thr 
    130                 135                 140                 


Gly Arg Asn Cys Leu Phe Asn Lys Ala Ile Pro Ala His Met Ser Glu 
145                 150                 155                 160 


His Ser Val Val Gly Ile Thr Trp Asp Asn Asp Arg Val Thr Val Phe 
                165                 170                 175     


Ser Asp Lys Ile Tyr Tyr Phe Tyr Phe Lys Asn Asp Trp Ser Arg Val 
            180                 185                 190         


Ala Thr Lys Cys Tyr Asn Ser Gly Gly Cys Ala Met Gln Tyr Val Tyr 
        195                 200                 205             


Glu Pro Thr Tyr Tyr Met Leu Asn Val Thr Ser Ala Gly Glu Asp Gly 
    210                 215                 220                 


Ile Ser Tyr Gln Pro Cys Thr Ala Asn Cys Ile Gly Tyr Ala Ala Asn 
225                 230                 235                 240 


Val Phe Ala Thr Glu Pro Asn Gly His Ile Pro Glu Gly Phe Ser Phe 
                245                 250                 255     


Asn Asn Trp Phe Leu Leu Ser Asn Asp Ser Thr Leu Val His Gly Lys 
            260                 265                 270         


Val Val Ser Asn Gln Pro Leu Leu Val Asn Cys Leu Leu Ala Ile Pro 
        275                 280                 285             


Lys Ile Tyr Gly Leu Gly Gln Phe Phe Ser Phe Asn Gln Thr Ile Asp 
    290                 295                 300                 


Gly Val Cys Asn Gly Ala Ala Val Gln Arg Ala Pro Glu Ala Leu Arg 
305                 310                 315                 320 


Phe Asn Ile Asn Asp Thr Ser Val Ile Leu Ala Glu Gly Ser Ile Val 
                325                 330                 335     


Leu His Thr Ala Leu Gly Thr Asn Phe Ser Phe Val Cys Ser Asn Ser 
            340                 345                 350         


Ser Asn Pro His Leu Ala Thr Phe Ala Ile Pro Leu Gly Ala Thr Gln 
        355                 360                 365             


Val Pro Tyr Tyr Cys Phe Leu Lys Val Asp Thr Tyr Asn Ser Thr Val 
    370                 375                 380                 


Tyr Lys Phe Leu Ala Val Leu Pro Pro Thr Val Arg Glu Ile Val Ile 
385                 390                 395                 400 


Thr Lys Tyr Gly Asp Val Tyr Val Asn Gly Phe Gly Tyr Leu His Leu 
                405                 410                 415     


Gly Leu Leu Asp Ala Val Thr Ile Asn Phe Thr Gly His Gly Thr Asp 
            420                 425                 430         


Asp Asp Val Ser Gly Phe Trp Thr Ile Ala Ser Thr Asn Phe Val Asp 
        435                 440                 445             


Ala Leu Ile Glu Val Gln Gly Thr Ala Ile Gln Arg Ile Leu Tyr Cys 
    450                 455                 460                 


Asp Asp Pro Val Ser Gln Leu Lys Cys Ser Gln Val Ala Phe Asp Leu 
465                 470                 475                 480 


Asp Asp Gly Phe Tyr Pro Ile Ser Ser Arg Asn Leu Leu Ser His Glu 
                485                 490                 495     


Gln Pro Ile Ser Phe Val Thr Leu Pro Ser Phe Asn Asp His Ser Phe 
            500                 505                 510         


Val Asn Ile Thr Val Ser Ala Ser Phe Gly Gly His Ser Gly Ala Asn 
        515                 520                 525             


Leu Ile Ala Ser Asp Thr Thr Ile Asn Gly Phe Ser Ser Phe Cys Val 
    530                 535                 540                 


Asp Thr Arg Gln Phe Thr Ile Ser Leu Phe Tyr Asn Val Thr Asn Ser 
545                 550                 555                 560 


Tyr Gly Tyr Val Ser Lys Ser Gln Asp Ser Asn Cys Pro Phe Thr Leu 
                565                 570                 575     


Gln Ser Val Asn Asp Tyr Leu Ser Phe Ser Lys Phe Cys Val Ser Thr 
            580                 585                 590         


Ser Leu Leu Ala Ser Ala Cys Thr Ile Asp Leu Phe Gly Tyr Pro Glu 
        595                 600                 605             


Phe Gly Ser Gly Val Lys Phe Thr Ser Leu Tyr Phe Gln Phe Thr Lys 
    610                 615                 620                 


Gly Glu Leu Ile Thr Gly Thr Pro Lys Pro Leu Glu Gly Val Thr Asp 
625                 630                 635                 640 


Val Ser Phe Met Thr Leu Asp Val Cys Thr Lys Tyr Thr Ile Tyr Gly 
                645                 650                 655     


Phe Lys Gly Glu Gly Ile Ile Thr Leu Thr Asn Ser Ser Phe Leu Ala 
            660                 665                 670         


Gly Val Tyr Tyr Thr Ser Asp Ser Gly Gln Leu Leu Ala Phe Lys Asn 
        675                 680                 685             


Val Thr Ser Gly Ala Val Tyr Ser Val Thr Pro Cys Ser Phe Ser Glu 
    690                 695                 700                 


Gln Ala Ala Tyr Val Asp Asp Asp Ile Val Gly Val Ile Ser Ser Leu 
705                 710                 715                 720 


Ser Ser Ser Thr Phe Asn Ser Thr Arg Glu Leu Pro Gly Phe Phe Tyr 
                725                 730                 735     


His Ser Asn Asp Gly Ser Asn Cys Thr Glu Pro Val Leu Val Tyr Ser 
            740                 745                 750         


Asn Ile Gly Val Cys Lys Ser Gly Ser Ile Gly Tyr Val Pro Ser Gln 
        755                 760                 765             


Ser Gly Gln Val Lys Ile Ala Pro Thr Val Thr Gly Asn Ile Ser Ile 
    770                 775                 780                 


Pro Thr Asn Phe Ser Met Ser Ile Arg Thr Glu Tyr Leu Gln Leu Tyr 
785                 790                 795                 800 


Asn Thr Pro Val Ser Val Asp Cys Ala Thr Tyr Val Cys Asn Gly Asn 
                805                 810                 815     


Ser Arg Cys Lys Gln Leu Leu Thr Gln Tyr Thr Ala Ala Cys Lys Thr 
            820                 825                 830         


Ile Glu Ser Ala Leu Gln Leu Ser Ala Arg Leu Glu Ser Val Glu Val 
        835                 840                 845             


Asn Ser Met Leu Thr Ile Ser Glu Glu Ala Leu Gln Leu Ala Thr Ile 
    850                 855                 860                 


Ser Ser Phe Asn Gly Asp Gly Tyr Asn Phe Thr Asn Val Leu Gly Val 
865                 870                 875                 880 


Ser Val Tyr Asp Pro Ala Ser Gly Arg Val Val Gln Lys Arg Ser Phe 
                885                 890                 895     


Ile Glu Asp Leu Leu Phe Asn Lys Val Val Thr Asn Gly Leu Gly Thr 
            900                 905                 910         


Val Asp Glu Asp Tyr Lys Arg Cys Ser Asn Gly Arg Ser Val Ala Asp 
        915                 920                 925             


Leu Val Cys Ala Gln Tyr Tyr Ser Gly Val Met Val Leu Pro Gly Val 
    930                 935                 940                 


Val Asp Ala Glu Lys Leu His Met Tyr Ser Ala Ser Leu Ile Gly Gly 
945                 950                 955                 960 


Met Val Leu Gly Gly Phe Thr Ser Ala Ala Ala Leu Pro Phe Ser Tyr 
                965                 970                 975     


Ala Val Gln Ala Arg Leu Asn Tyr Leu Ala Leu Gln Thr Asp Val Leu 
            980                 985                 990         


Gln Arg Asn Gln Gln Leu Leu Ala  Glu Ser Phe Asn Ser  Ala Ile Gly 
        995                 1000                 1005             


Asn Ile  Thr Ser Ala Phe Glu  Ser Val Lys Glu Ala  Ile Ser Gln 
    1010                 1015                 1020             


Thr Ser  Lys Gly Leu Asn Thr  Val Ala His Ala Leu  Thr Lys Val 
    1025                 1030                 1035             


Gln Glu  Val Val Asn Ser Gln  Gly Ala Ala Leu Thr  Gln Leu Thr 
    1040                 1045                 1050             


Val Gln  Leu Gln His Asn Phe  Gln Ala Ile Ser Ser  Ser Ile Asp 
    1055                 1060                 1065             


Asp Ile  Tyr Ser Arg Leu Asp  Ile Leu Ser Ala Asp  Val Gln Val 
    1070                 1075                 1080             


Asp Arg  Leu Ile Thr Gly Arg  Leu Ser Ala Leu Asn  Ala Phe Val 
    1085                 1090                 1095             


Ala Gln  Thr Leu Thr Lys Tyr  Thr Glu Val Gln Ala  Ser Arg Lys 
    1100                 1105                 1110             


Leu Ala  Gln Gln Lys Val Asn  Glu Cys Val Lys Ser  Gln Ser Gln 
    1115                 1120                 1125             


Arg Tyr  Gly Phe Cys Gly Gly  Asp Gly Glu His Ile  Phe Ser Leu 
    1130                 1135                 1140             


Val Gln  Ala Ala Pro Gln Gly  Leu Leu Phe Leu His  Thr Val Leu 
    1145                 1150                 1155             


Val Pro  Ser Asp Phe Val Asp  Val Ile Ala Ile Ala  Gly Leu Cys 
    1160                 1165                 1170             


Val Asn  Asp Glu Ile Ala Leu  Thr Leu Arg Glu Pro  Gly Leu Val 
    1175                 1180                 1185             


Leu Phe  Thr His Glu Leu Gln  Asn His Thr Ala Thr  Glu Tyr Phe 
    1190                 1195                 1200             


Val Ser  Ser Arg Arg Met Phe  Glu Pro Arg Lys Pro  Thr Val Ser 
    1205                 1210                 1215             


Asp Phe  Val Gln Ile Glu Ser  Cys Val Val Thr Tyr  Val Asn Leu 
    1220                 1225                 1230             


Thr Arg  Asp Gln Leu Pro Asp  Val Ile Pro Asp Tyr  Ile Asp Val 
    1235                 1240                 1245             


Asn Lys  Thr Leu Asp Glu Ile  Leu Ala Ser Leu Pro  Asn Arg Thr 
    1250                 1255                 1260             


Gly Pro  Ser Leu Pro Leu Asp  Val Phe Asn Ala Thr  Tyr Leu Asn 
    1265                 1270                 1275             


Leu Thr  Gly Glu Ile Ala Asp  Leu Glu Gln Arg Ser  Glu Ser Leu 
    1280                 1285                 1290             


Arg Asn  Thr Thr Glu Glu Leu  Gln Ser Leu Ile Tyr  Asn Ile Asn 
    1295                 1300                 1305             


Asn Thr  Leu Val Asp Leu Glu  Trp Leu Asn Arg Val  Glu Thr Tyr 
    1310                 1315                 1320             


Ile Lys  Trp Pro Trp Trp Val  Trp Leu Ile Ile Phe  Ile Val Leu 
    1325                 1330                 1335             


Ile Phe  Val Val Ser Leu Leu  Val Phe Cys Cys Ile  Ser Thr Gly 
    1340                 1345                 1350             


Cys Cys  Gly Cys Cys Gly Cys  Cys Cys Ala Cys Phe  Ser Gly Cys 
    1355                 1360                 1365             


Cys Arg  Gly Pro Arg Leu Gln  Pro Tyr Glu Val Phe  Glu Lys Val 
    1370                 1375                 1380             


His Val  Gln 
    1385     


<210>  22
<211>  1386
<212>  PRT
<213>  Porcine epidemic diarrhea virus


<220>
<221>  misc_feature
<222>  (728)..(728)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (905)..(905)
<223>  Xaa can be any naturally occurring amino acid

<400>  22

Met Arg Ser Leu Ile Tyr Phe Trp Leu Ser Leu Pro Val Leu Pro Thr 
1               5                   10                  15      


Leu Ser Leu Pro Gln Asp Val Tyr Arg Cys Ser Ala Arg Thr Asn Phe 
            20                  25                  30          


Arg Arg Phe Phe Ser Lys Phe Asn Val Gln Ala Pro Ala Val Val Val 
        35                  40                  45              


Leu Gly Gly Tyr Leu Pro Ser Gly Glu Thr Gln Gly Gly Ala Pro Arg 
    50                  55                  60                  


Trp Tyr Cys Ala Gly Arg His Glu Thr Ala Ser Gly Val His Gly Ile 
65                  70                  75                  80  


Phe Leu Ser His Ile Arg Gly Gly His Gly Phe Glu Ile Gly Ile Ser 
                85                  90                  95      


Gln Glu Pro Leu Asp Pro Ser Gly Tyr Gln Leu Tyr Leu His Lys Ala 
            100                 105                 110         


Thr Asn Gly Asn Thr Asn Ala Thr Ala Arg Leu Arg Ile Cys Gln Phe 
        115                 120                 125             


Pro Ser Asn Lys Thr Leu Gly Pro Thr Ala Asn Asp Asp Val Thr Thr 
    130                 135                 140                 


Gly Arg Asn Cys Leu Phe Asn Lys Ala Ile Pro Ala His Met Ser Glu 
145                 150                 155                 160 


His Ser Val Val Gly Ile Thr Trp Asp Asn Asp Arg Val Thr Val Phe 
                165                 170                 175     


Ala Asp Lys Ile Tyr His Phe Tyr Leu Lys Asn Glu Trp Ser Arg Val 
            180                 185                 190         


Ala Thr Lys Cys Tyr Asn Ser Gly Gly Cys Ala Met Gln Tyr Val Tyr 
        195                 200                 205             


Glu Pro Ile Tyr Tyr Met Leu Asn Val Thr Ser Ala Gly Glu Asp Gly 
    210                 215                 220                 


Ile Ser Tyr Gln Pro Cys Thr Ala Asn Cys Ile Gly Tyr Ala Ala Asn 
225                 230                 235                 240 


Val Phe Ala Thr Glu Ser Asn Gly His Ile Pro Glu Gly Phe Ser Phe 
                245                 250                 255     


Asn Asn Trp Phe Leu Leu Ser Asn Asp Ser Thr Leu Phe His Gly Lys 
            260                 265                 270         


Val Val Ser Asn Gln Pro Leu Leu Val Asn Cys Leu Trp Ala Ile Pro 
        275                 280                 285             


Lys Ile Tyr Gly Leu Gly His Phe Phe Ser Phe Asn Gln Thr Met Asp 
    290                 295                 300                 


Gly Val Cys Asn Gly Ala Thr Ala Tyr Arg Ala Pro Glu Ala Leu Arg 
305                 310                 315                 320 


Phe Asn Ile Asn Asp Thr Ser Val Ile Leu Ala Glu Gly Ser Ile Val 
                325                 330                 335     


Leu His Thr Ala Leu Gly Thr Asn Leu Ser Phe Val Cys Ser Asn Ser 
            340                 345                 350         


Ser Asp Pro His Lys Ala Ile Phe Ser Ile Pro Leu Gly Ala Thr Gln 
        355                 360                 365             


Val Pro Tyr Tyr Cys Phe Leu Lys Val Asp Thr Tyr Asn Ser Thr Val 
    370                 375                 380                 


Tyr Lys Phe Leu Ala Val Leu Pro Pro Thr Val Arg Glu Ile Val Ile 
385                 390                 395                 400 


Thr Lys Tyr Gly Asp Val Tyr Val Asn Gly Phe Gly Tyr Leu His Leu 
                405                 410                 415     


Gly Leu Leu Asp Ala Val Thr Ile Asn Phe Thr Gly His Gly Thr Asn 
            420                 425                 430         


Asp Asp Val Ser Gly Phe Trp Thr Ile Ala Ser Thr Asn Phe Ile Asp 
        435                 440                 445             


Ala Leu Val Glu Val Arg Ala Thr Ala Ile Gln Arg Ile Leu Tyr Cys 
    450                 455                 460                 


Asp Asp Pro Val Cys Gln Leu Lys Cys Ser Gln Val Ser Phe Asp Leu 
465                 470                 475                 480 


Asp Asp Gly Phe Tyr Pro Ile Ser Ser Arg Asn Leu Leu Ser His Glu 
                485                 490                 495     


Gln Pro Ile Ser Phe Val Thr Leu Pro Ser Phe Asn Asp His Ser Phe 
            500                 505                 510         


Val Asn Ile Thr Val Ser Ala Ala Phe Gly Asp Ser Gly Gly Ala Asn 
        515                 520                 525             


Leu Val Ala Ser Asp Thr Thr Ile Asn Gly Phe Ser Ser Phe Cys Val 
    530                 535                 540                 


Asp Thr Arg Gln Phe Thr Ile Arg Leu Phe Tyr Asn Val Thr Ser Ser 
545                 550                 555                 560 


Tyr Gly Tyr Val Ser Lys Ser Gln Asp Ser Asn Cys Pro Phe Thr Leu 
                565                 570                 575     


Gln Ser Val Asn Asp Tyr Leu Ser Phe Ser Lys Phe Cys Val Ser Thr 
            580                 585                 590         


Ser Leu Leu Ala Gly Ala Cys Thr Ile Asp Leu Phe Gly Tyr Pro Ala 
        595                 600                 605             


Phe Gly Ser Gly Val Lys Phe Thr Ser Leu Tyr Phe Gln Phe Thr Lys 
    610                 615                 620                 


Gly Glu Leu Ile Thr Gly Thr Pro Lys Pro Leu Glu Gly Val Thr Asp 
625                 630                 635                 640 


Val Ser Phe Met Thr Leu Asp Val Cys Thr Lys Tyr Thr Ile Tyr Gly 
                645                 650                 655     


Phe Lys Gly Glu Gly Ile Ile Thr Leu Thr Asn Ser Ser Phe Leu Ala 
            660                 665                 670         


Gly Val Tyr Tyr Thr Ser Asp Ser Gly Gln Leu Leu Ala Phe Lys Asn 
        675                 680                 685             


Val Thr Ser Gly Ala Val Tyr Ser Val Thr Pro Cys Ser Phe Ser Glu 
    690                 695                 700                 


Gln Ala Ala Tyr Val Asp Asp Asp Ile Val Gly Gly Ile Ser Ser Leu 
705                 710                 715                 720 


Ser Asn Ser Thr Phe Asn Asn Xaa Arg Asp Phe Pro Gly Phe Phe Tyr 
                725                 730                 735     


His Ser Asn Asp Gly Ser Asn Cys Thr Glu Pro Val Leu Val Tyr Ser 
            740                 745                 750         


Asn Ile Gly Val Cys Lys Ser Gly Ser Ile Gly Tyr Val Pro Leu Gln 
        755                 760                 765             


Asp Gly Gln Val Lys Ile Ala Pro Thr Val Ile Gly Asn Ile Ser Ile 
    770                 775                 780                 


Pro Thr Asn Phe Ser Met Ser Ile Arg Thr Glu Tyr Leu Gln Leu Tyr 
785                 790                 795                 800 


Asn Thr Pro Val Ser Val Asp Cys Ala Thr Tyr Val Cys Asn Gly Asn 
                805                 810                 815     


Ser Arg Cys Lys Gln Leu Leu Thr Gln Tyr Thr Ala Ala Cys Lys Thr 
            820                 825                 830         


Ile Glu Ser Ala Leu Glu Leu Ser Ala Arg Leu Glu Ser Val Glu Val 
        835                 840                 845             


Asn Ser Met Leu Thr Ile Ser Glu Glu Ala Leu Gln Leu Ala Thr Ile 
    850                 855                 860                 


Ser Ser Phe Asn Gly Asp Gly Tyr Asn Phe Thr Asn Val Leu Gly Val 
865                 870                 875                 880 


Ser Val Tyr Asp Ser Glu Ser Gly Arg Val Val His Glu Arg Ser Phe 
                885                 890                 895     


Ile Glu Asp Leu Leu Phe Asn Lys Xaa Val Thr Asn Gly Leu Gly Thr 
            900                 905                 910         


Val Asp Glu Asp Tyr Lys Arg Cys Ser Asn Gly Arg Ser Val Ala Asp 
        915                 920                 925             


Leu Val Cys Ala Gln Tyr Tyr Ser Gly Ile Met Val Leu Pro Gly Val 
    930                 935                 940                 


Val Asp Ala Glu Lys Leu His Met Tyr Ser Ala Ser Leu Ile Gly Gly 
945                 950                 955                 960 


Met Ala Leu Gly Gly Phe Thr Ala Ala Val Ala Leu Pro Phe Ser Tyr 
                965                 970                 975     


Ala Val Gln Ala Arg Leu Asn Tyr Leu Ala Leu Gln Thr Asp Val Leu 
            980                 985                 990         


Gln Arg Asn Gln Gln Leu Leu Ala  Glu Ser Phe Asn Ser  Ala Ile Gly 
        995                 1000                 1005             


Ser Ile  Thr Ser Ala Phe Glu  Ser Val Asn Glu Ala  Ile Ser Gln 
    1010                 1015                 1020             


Thr Ser  Lys Gly Leu Asn Thr  Val Ala His Ala Leu  Thr Lys Val 
    1025                 1030                 1035             


Gln Glu  Val Val Asn Ser Gln  Gly Ser Ala Leu Thr  Gln Leu Thr 
    1040                 1045                 1050             


Ile Gln  Leu Gln His Asn Phe  Gln Ala Ile Ser Ser  Ser Ile Asp 
    1055                 1060                 1065             


Asp Ile  Tyr Ser Arg Leu Asp  Ile Leu Ser Ala Asp  Val Gln Val 
    1070                 1075                 1080             


Asp Arg  Leu Ile Thr Gly Arg  Leu Ser Ala Leu Asn  Ala Phe Val 
    1085                 1090                 1095             


Ala Gln  Thr Leu Thr Lys Tyr  Thr Glu Val Gln Ala  Ser Arg Lys 
    1100                 1105                 1110             


Leu Ala  Gln Gln Lys Val Asn  Glu Cys Val Lys Ser  Gln Ser Gln 
    1115                 1120                 1125             


Arg Tyr  Gly Phe Cys Gly Gly  Asp Gly Glu His Ile  Phe Ser Leu 
    1130                 1135                 1140             


Val Gln  Ala Ala Pro Gln Gly  Leu Leu Phe Leu His  Thr Val Leu 
    1145                 1150                 1155             


Val Pro  Gly Asp Phe Val Asn  Val Ile Ala Ile Ala  Gly Leu Cys 
    1160                 1165                 1170             


Val Asn  Gly Asp Ile Ala Leu  Thr Leu Arg Glu Pro  Gly Leu Val 
    1175                 1180                 1185             


Leu Phe  Thr His Glu Leu Gln  Thr His Thr Ala Thr  Glu Tyr Phe 
    1190                 1195                 1200             


Val Ser  Ser Arg Arg Met Phe  Glu Pro Arg Lys Pro  Thr Val Ser 
    1205                 1210                 1215             


Asp Phe  Val Gln Ile Gln Ser  Cys Val Val Thr Tyr  Val Asn Leu 
    1220                 1225                 1230             


Thr Ser  Asp Gln Leu Pro Asp  Val Ile Pro Asp Tyr  Val Asp Val 
    1235                 1240                 1245             


Asn Lys  Thr Leu Asp Glu Ile  Leu Ala Ser Leu Pro  Asn Arg Thr 
    1250                 1255                 1260             


Gly Pro  Asn Leu Pro Leu Asp  Val Phe Asn Ala Thr  Tyr Leu Asn 
    1265                 1270                 1275             


Leu Thr  Gly Glu Ile Ala Asp  Leu Glu Gln Arg Ser  Glu Ser Leu 
    1280                 1285                 1290             


Arg Asn  Thr Thr Glu Glu Leu  Arg Ser Leu Ile Tyr  Asn Ile Asn 
    1295                 1300                 1305             


Asn Thr  Leu Val Asp Leu Glu  Trp Leu Asn Arg Val  Glu Thr Tyr 
    1310                 1315                 1320             


Ile Lys  Trp Pro Trp Trp Val  Trp Leu Ile Val Phe  Ile Val Leu 
    1325                 1330                 1335             


Ile Phe  Val Val Ser Leu Leu  Val Phe Cys Cys Ile  Ser Thr Gly 
    1340                 1345                 1350             


Cys Cys  Gly Cys Cys Gly Cys  Cys Gly Ala Cys Phe  Ser Gly Cys 
    1355                 1360                 1365             


Cys Arg  Gly Pro Arg Leu Gln  Pro Tyr Glu Ala Phe  Glu Lys Val 
    1370                 1375                 1380             


His Val  Gln 
    1385     


<210>  23
<211>  1382
<212>  PRT
<213>  Porcine epidemic diarrhea virus

<400>  23

Met Thr Pro Leu Ile Tyr Phe Trp Leu Phe Leu Pro Val Leu Leu Thr 
1               5                   10                  15      


Leu Ser Leu Pro Gln Asp Val Thr Arg Cys Gln Ser Thr Ile Asn Phe 
            20                  25                  30          


Arg Arg Phe Phe Ser Lys Phe Asn Val Gln Ala Pro Ala Val Val Val 
        35                  40                  45              


Leu Gly Gly Tyr Leu Pro Ser Met Asn Ser Ser Ser Trp Tyr Cys Gly 
    50                  55                  60                  


Thr Gly Ile Glu Thr Asp Ser Gly Val His Gly Ile Phe Leu Ser Tyr 
65                  70                  75                  80  


Ile Asp Ser Gly Gln Gly Phe Glu Ile Gly Ile Ser Gln Glu Pro Phe 
                85                  90                  95      


Asp Pro Ser Gly Tyr Gln Leu Tyr Leu His Lys Ala Thr Asn Gly Asn 
            100                 105                 110         


Thr Ser Ala Ile Ala Arg Leu Arg Ile Cys Gln Phe Pro Asp Asn Lys 
        115                 120                 125             


Thr Leu Gly Pro Thr Val Asn Asp Val Thr Thr Gly Arg Asn Cys Leu 
    130                 135                 140                 


Phe Asn Lys Ala Ile Pro Ala Leu Gln Asp Gly Lys Asn Ile Val Val 
145                 150                 155                 160 


Gly Ile Thr Trp Asp Asn Asp Arg Val Thr Val Phe Ala Asp Lys Ile 
                165                 170                 175     


Tyr His Phe Tyr Ile Lys Asn Asp Trp Ser Arg Val Ala Thr Arg Cys 
            180                 185                 190         


Tyr Asn Lys Arg Ser Cys Ala Met Gln Tyr Val Tyr Thr Pro Thr Tyr 
        195                 200                 205             


Tyr Met Leu Asn Val Thr Ser Ala Gly Glu Asp Gly Ile Tyr Tyr Glu 
    210                 215                 220                 


Pro Cys Thr Ala Asn Cys Ser Gly Tyr Ala Ala Asn Val Phe Ala Thr 
225                 230                 235                 240 


Asp Ser Asn Gly His Ile Pro Glu Gly Phe Ser Phe Asn Asn Trp Phe 
                245                 250                 255     


Leu Leu Ser Asn Asp Ser Thr Leu Leu His Gly Lys Val Val Ser Asn 
            260                 265                 270         


Gln Pro Leu Leu Val Asn Cys Leu Arg Ala Ile Pro Lys Ile Tyr Gly 
        275                 280                 285             


Leu Gly Gln Phe Phe Ser Phe Asn Gln Thr Met Asp Gly Val Cys Asn 
    290                 295                 300                 


Gly Ala Ala Ala Gln Arg Ala Pro Glu Ala Leu Arg Phe Asn Ile Asn 
305                 310                 315                 320 


Asp Thr Phe Val Ile Leu Ala Glu Gly Ser Ile Val Leu His Thr Ala 
                325                 330                 335     


Leu Gly Thr Asn Leu Ser Phe Val Cys Ser Asn Ser Ser Asp Pro His 
            340                 345                 350         


Lys Ala Ile Phe Thr Ile Pro Leu Gly Val Thr Glu Val Pro Tyr Tyr 
        355                 360                 365             


Cys Phe Leu Lys Val Asp Thr Tyr Lys Ser Thr Val Tyr Lys Phe Leu 
    370                 375                 380                 


Ala Val Leu Pro Pro Thr Val Lys Glu Ile Val Ile Thr Lys Tyr Gly 
385                 390                 395                 400 


Asp Val Tyr Val Asn Gly Phe Gly Tyr Leu His Leu Gly Leu Leu Asp 
                405                 410                 415     


Ala Val Thr Ile Asn Phe Thr Gly His Gly Thr Asp Asp Asp Val Ser 
            420                 425                 430         


Gly Phe Trp Thr Val Ala Ser Thr Asn Phe Val Asp Ala Leu Ile Glu 
        435                 440                 445             


Val Gln Gly Thr Ala Ile Gln Arg Ile Leu Tyr Cys Asp Asp Pro Val 
    450                 455                 460                 


Ser Gln Leu Lys Cys Ser Gln Val Ser Phe Asp Leu Asp Asp Gly Phe 
465                 470                 475                 480 


Tyr Pro Ile Ser Ser Arg Asn Leu Leu Ser His Glu Gln Pro Ile Ser 
                485                 490                 495     


Phe Val Thr Leu Pro Ser Phe Asn Asp His Ser Phe Val Asn Ile Thr 
            500                 505                 510         


Val Ser Ala Ala Phe Gly Gly His Ser Gly Ala Asn Leu Ile Ala Ser 
        515                 520                 525             


Asp Thr Thr Thr Asn Gly Phe Ser Ser Phe Cys Val Asp Thr Arg Gln 
    530                 535                 540                 


Phe Thr Ile Thr Leu Phe Tyr Asn Val Thr Asn Ser Tyr Gly Tyr Val 
545                 550                 555                 560 


Ser Lys Ser Gln Asp Ser Asn Cys Pro Phe Thr Leu Gln Ser Val Asn 
                565                 570                 575     


Asp Tyr Leu Ser Phe Ser Lys Phe Cys Val Ser Thr Ser Leu Leu Ala 
            580                 585                 590         


Gly Ala Cys Thr Ile Asp Leu Phe Gly Tyr Pro Glu Phe Gly Ser Gly 
        595                 600                 605             


Val Lys Phe Thr Ser Leu Tyr Phe Gln Phe Thr Lys Gly Glu Leu Ile 
    610                 615                 620                 


Thr Gly Thr Pro Lys Pro Leu Gln Gly Val Thr Asp Val Ser Phe Met 
625                 630                 635                 640 


Thr Leu Asp Val Cys Thr Lys Tyr Thr Ile Tyr Gly Phe Lys Gly Glu 
                645                 650                 655     


Gly Ile Ile Thr Leu Thr Asn Ser Ser Phe Leu Ala Gly Val Tyr Tyr 
            660                 665                 670         


Thr Ser Asp Ser Gly Gln Leu Leu Ala Phe Lys Asn Val Thr Ser Gly 
        675                 680                 685             


Ala Val Tyr Ser Val Thr Pro Cys Ser Phe Ser Glu Gln Ala Ala Tyr 
    690                 695                 700                 


Val Asp Asp Asp Ile Val Gly Val Ile Ser Ser Leu Ser Asn Ser Thr 
705                 710                 715                 720 


Phe Asn Asn Thr Arg Glu Leu Pro Gly Phe Phe Tyr His Ser Asn Asp 
                725                 730                 735     


Gly Ser Asn Cys Thr Glu Pro Val Leu Val Tyr Ser Asn Ile Gly Val 
            740                 745                 750         


Cys Lys Ser Gly Ser Ile Gly Tyr Val Pro Leu Gln Asp Gly Gln Val 
        755                 760                 765             


Lys Ile Ala Pro Met Val Thr Gly Asn Ile Ser Ile Pro Thr Asn Phe 
    770                 775                 780                 


Ser Met Ser Ile Arg Thr Glu Tyr Leu Gln Leu Tyr Asn Thr Pro Val 
785                 790                 795                 800 


Ser Val Asp Cys Val Thr Tyr Val Cys Asn Gly Asn Ser Arg Cys Lys 
                805                 810                 815     


Gln Leu Leu Thr Gln Tyr Thr Ala Ala Cys Lys Thr Ile Glu Ser Ala 
            820                 825                 830         


Leu Gln Leu Ser Ala Arg Leu Glu Ser Val Glu Val Asn Ser Met Leu 
        835                 840                 845             


Thr Ile Ser Glu Glu Ala Leu Gln Leu Ala Thr Ile Ser Ser Phe Asn 
    850                 855                 860                 


Gly Asp Gly Tyr Asn Phe Thr Asn Val Leu Gly Val Ser Val Tyr Asp 
865                 870                 875                 880 


Pro Ala Ser Gly Arg Val Val Gln Lys Gly Ser Phe Ile Glu Asp Leu 
                885                 890                 895     


Leu Phe Asn Lys Val Val Thr Asn Gly Leu Gly Thr Val Asp Glu Asp 
            900                 905                 910         


Tyr Lys Arg Cys Ser Asn Gly Arg Ser Val Ala Asp Leu Val Cys Ala 
        915                 920                 925             


Gln Tyr Tyr Ser Gly Val Met Val Leu Pro Gly Val Val Asp Ala Glu 
    930                 935                 940                 


Lys Leu His Met Tyr Ser Ala Ser Leu Leu Gly Gly Met Ala Leu Gly 
945                 950                 955                 960 


Gly Leu Thr Thr Ala Ala Ala Leu Pro Phe Ser Asn Ala Val Gln Ala 
                965                 970                 975     


Arg Leu Asn Tyr Leu Ala Leu Gln Thr Asp Val Leu Gln Arg Asn Gln 
            980                 985                 990         


Gln Leu Leu Ala Glu Ser Phe Asn  Ser Ala Ile Gly Asn  Ile Thr Ser 
        995                 1000                 1005             


Ala Phe  Glu Ser Val Lys Glu  Ala Ile Ser Gln Thr  Ser Asn Gly 
    1010                 1015                 1020             


Leu Asn  Thr Val Ala His Ala  Leu Thr Lys Val Gln  Glu Val Val 
    1025                 1030                 1035             


Lys Ser  Gln Gly Ser Ala Leu  Thr Gln Leu Thr Ile  Gln Leu Gln 
    1040                 1045                 1050             


His Asn  Phe Gln Ala Ile Ser  Ser Ser Ile Asp Asp  Ile Tyr Ser 
    1055                 1060                 1065             


Arg Leu  Asp Ile Leu Ser Ala  Asp Val Gln Val Asp  Arg Leu Ile 
    1070                 1075                 1080             


Thr Gly  Arg Leu Ser Ala Leu  Asn Ala Phe Val Ala  Gln Thr Leu 
    1085                 1090                 1095             


Thr Lys  Tyr Thr Glu Val Gln  Ala Ser Arg Lys Leu  Ala Gln Gln 
    1100                 1105                 1110             


Lys Val  Asn Glu Cys Val Lys  Ser Gln Ser Gln Arg  Tyr Gly Phe 
    1115                 1120                 1125             


Cys Gly  Gly Asp Gly Glu His  Ile Phe Ser Leu Val  Gln Ala Ala 
    1130                 1135                 1140             


Pro Gln  Gly Leu Leu Phe Leu  His Thr Val Leu Val  Pro Gly Asp 
    1145                 1150                 1155             


Phe Val  Asn Val Ile Ala Ile  Asp Gly Leu Cys Val  Asn Gly Asp 
    1160                 1165                 1170             


Ile Ala  Leu Thr Leu Arg Glu  Pro Gly Leu Val Leu  Phe Thr His 
    1175                 1180                 1185             


Glu Leu  Gln Thr Tyr Thr Ala  Thr Glu Tyr Phe Val  Ser Ser Arg 
    1190                 1195                 1200             


Arg Met  Phe Glu Pro Arg Lys  Pro Thr Val Ser Asp  Phe Val Gln 
    1205                 1210                 1215             


Ile Glu  Ser Cys Val Val Thr  Tyr Val Asn Leu Thr  Ser Asp Gln 
    1220                 1225                 1230             


Leu Pro  Asp Val Ile Pro Asp  Tyr Ile Asp Val Asn  Lys Thr Leu 
    1235                 1240                 1245             


Asp Glu  Ile Leu Ala Ser Leu  Pro Asn Arg Ile Gly  Pro Ser Leu 
    1250                 1255                 1260             


Pro Leu  Asp Val Phe Asn Ala  Thr Tyr Leu Asn Leu  Thr Gly Glu 
    1265                 1270                 1275             


Ile Ala  Asp Leu Glu Gln Arg  Ser Glu Ser Leu Arg  Asn Thr Thr 
    1280                 1285                 1290             


Glu Glu  Leu Arg Ser Leu Ile  Tyr Asn Ile Asn Asn  Thr Leu Val 
    1295                 1300                 1305             


Asp Leu  Glu Trp Leu Asn Arg  Val Glu Thr Tyr Ile  Lys Trp Pro 
    1310                 1315                 1320             


Trp Trp  Val Trp Leu Ile Ile  Phe Ile Val Leu Ile  Phe Val Val 
    1325                 1330                 1335             


Ser Leu  Leu Val Phe Cys Cys  Ile Ser Thr Gly Cys  Cys Gly Cys 
    1340                 1345                 1350             


Cys Gly  Cys Cys Gly Ala Cys  Phe Ser Gly Cys Cys  Arg Gly Pro 
    1355                 1360                 1365             


Arg Leu  Gln Pro Tyr Glu Ala  Phe Glu Lys Val His  Val Gln 
    1370                 1375                 1380         


<210>  24
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Endoplasmic reticulum signal sequence

<400>  24

His Asp Glu Leu 
1               


<210>  25
<211>  2217
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  25
atggcgaaca agcacctgag ccttagcctc ttcctcgtgc tcctgggcct ctccgcctcc       60

ctcgcctccg gcgtcactcg ctgccagtcg accatcaact tccgcaggtt cttctccaag      120

ttcaacgtgc aggcccccgc ggtggtggtg ctcggcggct acctgccctc catgaattct      180

agctcctggt actgcggcac gggcatcgag acggactcgg gcgtgcacgg catcttcctc      240

agctacatcg actccggcca gggcttcgag atcggcatct cgcaggagcc cttcgaccca      300

tcgggctacc agctctacct gcacaaggcc accaacggca acacgaacgc gatcgcccgc      360

ctcaggatct gccagttccc ggacaacaag accctgggcc caaccgtcaa cgacgtgacc      420

accggccgca actgcctgtt caacaaggcg atcccggcct acctccagga cggcaagaac      480

atcgtcgtgg gcatcacgtg ggacaacgac agggtcaccg tgttcgcgga caagatctac      540

cacttctacc tcaagaacga ctggtcccgc gtcgcgacca ggtgctacaa caagcgcagc      600

tgcgccatgc agtatgtgta caccccgacg tactacatgc tcaacgtgac ctcggcgggc      660

gaggacggca tctactacga gccgtgcacg gccaactgct cgggctacgc ggccaacgtg      720

ttcgctaccg actccaacgg ccacatcccg gagggcttca gcttcaacaa ctggttcctc      780

ctgagcaacg actccaccct cctgcacggc aaggtcgtgt ccaaccagcc gctcctggtc      840

aactgcctcc tggcgatccc caagatctac ggcctgggcc agttcttcag cttcaaccag      900

acgatggacg gcgtgtgcaa cggcgcggcc gctcagaggg cccccgaggc cctcaggttc      960

aacatcaacg acacgagcgt catcctggcc gagggctcca tcgtgctcca cacggctctg     1020

ggcacgaacc tcagcttcgt gtgctccaac agctccgacc cccacctggc catcttcgct     1080

atccccctgg gcgccacgga ggtcccctac tactgcttcc tgaaggtgga cacctacaac     1140

agcacggtct acaagttcct ggcggtgctg ccgcccacgg tcagggagat cgtgatcacc     1200

aagtacggcg acgtctacgt gaacggcttc ggctacctcc acctgggcct cctggacgcg     1260

gtcaccatca acttcaccgg ccacggcacg gacgacgacg tgagcggctt ctggacgatc     1320

gcgagcacca acttcgtgga cgctctcatc gaggtgcagg gcaccgcgat ccagaggatc     1380

ctgtactgcg acgacccggt cagccagctc aagtgctccc aggtggcctt cgacctggac     1440

gacggcttct accccatcag ctcccgcaac ctcctgagcc acgagcagcc gatctccttc     1500

gtcaccctgc ccagcttcaa cgaccactcc ttcgtcaaca tcacggtgag cgccgctttc     1560

ggtggccact cgggcgccaa cctcatcgct tccgacacca cgatcaacgg cttcagctcc     1620

ttctgcgtgg acacgcgcca gttcaccatc acgctgttct acaacgtcac caactcctac     1680

ggctacgtga gcaagtccca ggactccaac tgcccgttca ccctgcagag cgtcaacgac     1740

tacctcagct tctccaagtt ctgcgtgagc acgtccctcc tggccggcgc ttgcaccatc     1800

gacctcttcg gctaccccga gttcggcagc ggcgtcaagt tcacgtccct gtacttccag     1860

ttcaccaagg gcgagctgat cacgggcacc cccaagccac tggagggcgt cacggacgtg     1920

agcttcatga ccctcgacgt gtgcaccaag tacacgatct acggcttcaa gggcgagggc     1980

atcatcaccc tgacgaactc aagctttctc gccggcgtct actacaccag cgactccggc     2040

cagctcctgg cgttcaagaa cgtgacctcg ggcgcggtct actcggtgac gccctgcagc     2100

ttctccgagc aggccgccta cgtggacgac gacatcgtcg gcgtgatcag ctccctgagc     2160

aactcaacat tcaacaacac tcgggagctg cctggcttct tctaccattc ctgatag        2217


