                         SEQUENCE LISTING



<110>  Sunnybrook Research Institute

       The Governing Council of the University of Toronto

 

<120>  Method and Compositions for Neuronal Reprogramming



<130>  509459-WO



<150>  US 63/208627

<151>  2021-06-09



<160>  55    



<170>  PatentIn version 3.5



<210>  1

<211>  237

<212>  PRT

<213>  Homo sapiens



<400>  1



Met Glu Ser Ser Ala Lys Met Glu Ser Gly Gly Ala Gly Gln Gln Pro 

1               5                   10                  15      





Gln Pro Gln Pro Gln Gln Pro Phe Leu Pro Pro Ala Ala Cys Phe Phe 

            20                  25                  30          





Ala Thr Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Gln 

        35                  40                  45              





Ser Ala Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Ala Pro 

    50                  55                  60                  





Gln Leu Arg Pro Ala Ala Asp Gly Gln Pro Ser Gly Gly Gly His Lys 

65                  70                  75                  80  





Ser Ala Pro Lys Gln Val Lys Arg Gln Arg Ser Ser Ser Pro Glu Leu 

                85                  90                  95      





Met Arg Cys Lys Arg Arg Leu Asn Phe Ser Gly Phe Gly Tyr Ser Leu 

            100                 105                 110         





Pro Gln Gln Gln Pro Ala Ala Val Ala Arg Arg Asn Glu Arg Glu Arg 

        115                 120                 125             





Asn Arg Val Lys Leu Val Asn Leu Gly Phe Ala Thr Leu Arg Glu His 

    130                 135                 140                 





Val Pro Asn Gly Ala Ala Asn Lys Lys Met Ser Ser Lys Val Glu Thr 

145                 150                 155                 160 





Leu Arg Ser Ala Val Glu Tyr Ile Arg Ala Leu Gln Gln Leu Leu Asp 

                165                 170                 175     





Glu His Asp Ala Val Ser Ala Ala Phe Gln Ala Gly Val Leu Ser Pro 

            180                 185                 190         





Thr Ile Ser Pro Asn Tyr Ser Asn Asp Leu Asn Ser Met Ala Gly Ser 

        195                 200                 205             





Pro Val Ser Ser Tyr Ser Ser Asp Glu Gly Ser Tyr Asp Pro Leu Ser 

    210                 215                 220                 





Pro Glu Glu Gln Glu Leu Leu Asp Phe Thr Asn Trp Phe 

225                 230                 235         





<210>  2

<211>  231

<212>  PRT

<213>  Mus musculus



<400>  2



Met Glu Ser Ser Gly Lys Met Glu Ser Gly Ala Gly Gln Gln Pro Gln 

1               5                   10                  15      





Pro Pro Gln Pro Phe Leu Pro Pro Ala Ala Cys Phe Phe Ala Thr Ala 

            20                  25                  30          





Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Gln Ser Ala Gln Gln 

        35                  40                  45              





Gln Gln Pro Gln Ala Pro Pro Gln Gln Ala Pro Gln Leu Ser Pro Val 

    50                  55                  60                  





Ala Asp Ser Gln Pro Ser Gly Gly Gly His Lys Ser Ala Ala Lys Gln 

65                  70                  75                  80  





Val Lys Arg Gln Arg Ser Ser Ser Pro Glu Leu Met Arg Cys Lys Arg 

                85                  90                  95      





Arg Leu Asn Phe Ser Gly Phe Gly Tyr Ser Leu Pro Gln Gln Gln Pro 

            100                 105                 110         





Ala Ala Val Ala Arg Arg Asn Glu Arg Glu Arg Asn Arg Val Lys Leu 

        115                 120                 125             





Val Asn Leu Gly Phe Ala Thr Leu Arg Glu His Val Pro Asn Gly Ala 

    130                 135                 140                 





Ala Asn Lys Lys Met Ser Lys Val Glu Thr Leu Arg Ser Ala Val Glu 

145                 150                 155                 160 





Tyr Ile Arg Ala Leu Gln Gln Leu Leu Asp Glu His Asp Ala Val Ser 

                165                 170                 175     





Ala Ala Phe Gln Ala Gly Val Leu Ser Pro Thr Ile Ser Pro Asn Tyr 

            180                 185                 190         





Ser Asn Asp Leu Asn Ser Met Ala Gly Ser Pro Val Ser Ser Tyr Ser 

        195                 200                 205             





Ser Asp Glu Gly Ser Tyr Asp Pro Leu Ser Pro Glu Glu Gln Glu Leu 

    210                 215                 220                 





Leu Asp Phe Thr Asn Trp Phe 

225                 230     





<210>  3

<211>  231

<212>  PRT

<213>  Mus musculus



<400>  3



Met Glu Ser Ser Gly Lys Met Glu Ser Gly Ala Gly Gln Gln Pro Gln 

1               5                   10                  15      





Pro Pro Gln Pro Phe Leu Pro Pro Ala Ala Cys Phe Phe Ala Thr Ala 

            20                  25                  30          





Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Gln Ser Ala Gln Gln 

        35                  40                  45              





Gln Gln Pro Gln Ala Pro Pro Gln Gln Ala Pro Gln Leu Ala Pro Val 

    50                  55                  60                  





Ala Asp Ser Gln Pro Ser Gly Gly Gly His Lys Ser Ala Ala Lys Gln 

65                  70                  75                  80  





Val Lys Arg Gln Arg Ser Ser Ala Pro Glu Leu Met Arg Cys Lys Arg 

                85                  90                  95      





Arg Leu Asn Phe Ser Gly Phe Gly Tyr Ser Leu Pro Gln Gln Gln Pro 

            100                 105                 110         





Ala Ala Val Ala Arg Arg Asn Glu Arg Glu Arg Asn Arg Val Lys Leu 

        115                 120                 125             





Val Asn Leu Gly Phe Ala Thr Leu Arg Glu His Val Pro Asn Gly Ala 

    130                 135                 140                 





Ala Asn Lys Lys Met Ser Lys Val Glu Thr Leu Arg Ser Ala Val Glu 

145                 150                 155                 160 





Tyr Ile Arg Ala Leu Gln Gln Leu Leu Asp Glu His Asp Ala Val Ser 

                165                 170                 175     





Ala Ala Phe Gln Ala Gly Val Leu Ala Pro Thr Ile Ala Pro Asn Tyr 

            180                 185                 190         





Ser Asn Asp Leu Asn Ser Met Ala Gly Ala Pro Val Ser Ser Tyr Ser 

        195                 200                 205             





Ser Asp Glu Gly Ser Tyr Asp Pro Leu Ala Pro Glu Glu Gln Glu Leu 

    210                 215                 220                 





Leu Asp Phe Thr Asn Trp Phe 

225                 230     





<210>  4

<211>  696

<212>  DNA

<213>  Mus musculus



<400>  4

atggagagct ctggcaagat ggagagtgga gccggccagc agccgcagcc cccgcagccc       60



ttcctgcctc ccgcagcctg cttctttgcg accgcggcgg cggcggcagc ggcggcggcc      120



gcggcagctc agagcgcgca gcagcaacag ccgcaggcgc cgccgcagca ggcgccgcag      180



ctggccccgg tggccgacag ccagccctca gggggcggtc acaagtcagc ggccaagcag      240



gtcaagcgcc agcgctcgtc cgctccggaa ctgatgcgct gcaaacgccg gctcaacttc      300



agcggcttcg gctacagcct gccacagcag cagccggccg ccgtggcgcg ccgcaacgag      360



cgcgagcgca accgggtcaa gttggtcaac ctgggctttg ccaccctccg ggagcatgtc      420



cccaacggcg cggccaacaa gaagatggcc aaggtggaga cgctgcgctc ggcggtcgag      480



tacatccgcg cgctgcagca gctgctggac gagcacgacg cggtgagcgc tgcctttcag      540



gcgggcgtcc tggcgcccac catcgccccc aactactcca acgacttgaa ctctatggcg      600



ggtgctccgg tctcgtccta ctcctccgac gagggatcct acgaccctct tgccccagag      660



gaacaagagc tgctggactt taccaactgg ttctga                                696





<210>  5

<211>  231

<212>  PRT

<213>  Mus musculus



<400>  5



Met Glu Ser Ser Gly Lys Met Glu Ser Gly Ala Gly Gln Gln Pro Gln 

1               5                   10                  15      





Pro Pro Gln Pro Phe Leu Pro Pro Ala Ala Cys Phe Phe Ala Thr Ala 

            20                  25                  30          





Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Gln Ser Ala Gln Gln 

        35                  40                  45              





Gln Gln Pro Gln Ala Pro Pro Gln Gln Ala Pro Gln Leu Ala Pro Val 

    50                  55                  60                  





Ala Asp Ser Gln Pro Ser Gly Gly Gly His Lys Ser Ala Ala Lys Gln 

65                  70                  75                  80  





Val Lys Arg Gln Arg Ser Ser Ala Pro Glu Leu Met Arg Cys Lys Arg 

                85                  90                  95      





Arg Leu Asn Phe Ser Gly Phe Gly Tyr Ser Leu Pro Gln Gln Gln Pro 

            100                 105                 110         





Ala Ala Val Ala Arg Arg Asn Glu Arg Glu Arg Asn Arg Val Lys Leu 

        115                 120                 125             





Val Asn Leu Gly Phe Ala Thr Leu Arg Glu His Val Pro Asn Gly Ala 

    130                 135                 140                 





Ala Asn Lys Lys Met Ala Lys Val Glu Thr Leu Arg Ser Ala Val Glu 

145                 150                 155                 160 





Tyr Ile Arg Ala Leu Gln Gln Leu Leu Asp Glu His Asp Ala Val Ser 

                165                 170                 175     





Ala Ala Phe Gln Ala Gly Val Leu Ala Pro Thr Ile Ala Pro Asn Tyr 

            180                 185                 190         





Ser Asn Asp Leu Asn Ser Met Ala Gly Ala Pro Val Ser Ser Tyr Ser 

        195                 200                 205             





Ser Asp Glu Gly Ser Tyr Asp Pro Leu Ala Pro Glu Glu Gln Glu Leu 

    210                 215                 220                 





Leu Asp Phe Thr Asn Trp Phe 

225                 230     





<210>  6

<211>  696

<212>  DNA

<213>  Mus musculus



<400>  6

atggagagct ctggcaagat ggagagtgga gccggccagc agccgcagcc cccgcagccc       60



ttcctgcctc ccgcagcctg cttctttgcg accgcggcgg cggcggcagc ggcggcggcc      120



gcggcagctc agagcgcgca gcagcaacag ccgcaggcgc cgccgcagca ggcgccgcag      180



ctggccccgg tggccgacag ccagccctca gggggcggtc acaagtcagc ggccaagcag      240



gtcaagcgcc agcgctcgtc cgctccggaa ctgatgcgct gcaaacgccg gctcaacttc      300



agcggcttcg gctacagcct gccacagcag cagccggccg ccgtggcgcg ccgcaacgag      360



cgcgagcgca accgggtcaa gttggtcaac ctgggctttg ccaccctccg ggagcatgtc      420



cccaacggcg cggccaacaa gaagatggcc aaggtggaga cgctgcgctc ggcggtcgag      480



tacatccgcg cgctgcagca gctgctggac gagcacgacg cggtgagcgc tgcctttcag      540



gcgggcgtcc tggcgcccac catcgccccc aactactcca acgacttgaa ctctatggcg      600



ggtgctccgg tctcgtccta ctcctccgac gagggatcct acgaccctct tgccccagag      660



gaacaagagc tgctggactt taccaactgg ttctga                                696





<210>  7

<211>  356

<212>  PRT

<213>  Homo sapiens



<400>  7



Met Thr Lys Ser Tyr Ser Glu Ser Gly Leu Met Gly Glu Pro Gln Pro 

1               5                   10                  15      





Gln Gly Pro Pro Ser Trp Thr Asp Glu Cys Leu Ser Ser Gln Asp Glu 

            20                  25                  30          





Glu His Glu Ala Asp Lys Lys Glu Asp Asp Leu Glu Thr Met Asn Ala 

        35                  40                  45              





Glu Glu Asp Ser Leu Arg Asn Gly Gly Glu Glu Glu Asp Glu Asp Glu 

    50                  55                  60                  





Asp Leu Glu Glu Glu Glu Glu Glu Glu Glu Glu Asp Asp Asp Gln Lys 

65                  70                  75                  80  





Pro Lys Arg Arg Gly Pro Lys Lys Lys Lys Met Thr Lys Ala Arg Leu 

                85                  90                  95      





Glu Arg Phe Lys Leu Arg Arg Met Lys Ala Asn Ala Arg Glu Arg Asn 

            100                 105                 110         





Arg Met His Gly Leu Asn Ala Ala Leu Asp Asn Leu Arg Lys Val Val 

        115                 120                 125             





Pro Cys Tyr Ser Lys Thr Gln Lys Leu Ser Lys Ile Glu Thr Leu Arg 

    130                 135                 140                 





Leu Ala Lys Asn Tyr Ile Trp Ala Leu Ser Glu Ile Leu Arg Ser Gly 

145                 150                 155                 160 





Lys Ser Pro Asp Leu Val Ser Phe Val Gln Thr Leu Cys Lys Gly Leu 

                165                 170                 175     





Ser Gln Pro Thr Thr Asn Leu Val Ala Gly Cys Leu Gln Leu Asn Pro 

            180                 185                 190         





Arg Thr Phe Leu Pro Glu Gln Asn Gln Asp Met Pro Pro His Leu Pro 

        195                 200                 205             





Thr Ala Ser Ala Ser Phe Pro Val His Pro Tyr Ser Tyr Gln Ser Pro 

    210                 215                 220                 





Gly Leu Pro Ser Pro Pro Tyr Gly Thr Met Asp Ser Ser His Val Phe 

225                 230                 235                 240 





His Val Lys Pro Pro Pro His Ala Tyr Ser Ala Ala Leu Glu Pro Phe 

                245                 250                 255     





Phe Glu Ser Pro Leu Thr Asp Cys Thr Ser Pro Ser Phe Asp Gly Pro 

            260                 265                 270         





Leu Ser Pro Pro Leu Ser Ile Asn Gly Asn Phe Ser Phe Lys His Glu 

        275                 280                 285             





Pro Ser Ala Glu Phe Glu Lys Asn Tyr Ala Phe Thr Met His Tyr Pro 

    290                 295                 300                 





Ala Ala Thr Leu Ala Gly Ala Gln Ser His Gly Ser Ile Phe Ser Gly 

305                 310                 315                 320 





Thr Ala Ala Pro Arg Cys Glu Ile Pro Ile Asp Asn Ile Met Ser Phe 

                325                 330                 335     





Asp Ser His Ser His His Glu Arg Val Met Ser Ala Gln Leu Asn Ala 

            340                 345                 350         





Ile Phe His Asp 

        355     





<210>  8

<211>  357

<212>  PRT

<213>  Mus musculus



<400>  8



Met Thr Lys Ser Tyr Ser Glu Ser Gly Leu Met Gly Glu Pro Gln Pro 

1               5                   10                  15      





Gln Gly Pro Pro Ser Trp Thr Asp Glu Cys Leu Ser Ser Gln Asp Glu 

            20                  25                  30          





Glu His Glu Ala Asp Lys Lys Glu Asp Glu Leu Glu Ala Met Asn Ala 

        35                  40                  45              





Glu Glu Asp Ser Leu Arg Asn Gly Gly Glu Glu Glu Glu Glu Asp Glu 

    50                  55                  60                  





Asp Leu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Asp Gln Lys 

65                  70                  75                  80  





Pro Lys Arg Arg Gly Pro Lys Lys Lys Lys Met Thr Lys Ala Arg Leu 

                85                  90                  95      





Glu Arg Phe Lys Leu Arg Arg Met Lys Ala Asn Ala Arg Glu Arg Asn 

            100                 105                 110         





Arg Met His Gly Leu Asn Ala Ala Leu Asp Asn Leu Arg Lys Val Val 

        115                 120                 125             





Pro Cys Tyr Ser Lys Thr Gln Lys Leu Ser Lys Ile Glu Thr Leu Arg 

    130                 135                 140                 





Leu Ala Lys Asn Tyr Ile Trp Ala Leu Ser Glu Ile Leu Arg Ser Gly 

145                 150                 155                 160 





Lys Ser Pro Asp Leu Val Ser Phe Val Gln Thr Leu Cys Lys Gly Leu 

                165                 170                 175     





Ser Gln Pro Thr Thr Asn Leu Val Ala Gly Cys Leu Gln Leu Asn Pro 

            180                 185                 190         





Arg Thr Phe Leu Pro Glu Gln Asn Pro Asp Met Pro Pro His Leu Pro 

        195                 200                 205             





Thr Ala Ser Ala Ser Phe Pro Val His Pro Tyr Ser Tyr Gln Ser Pro 

    210                 215                 220                 





Gly Leu Pro Ser Pro Pro Tyr Gly Thr Met Asp Ser Ser His Val Phe 

225                 230                 235                 240 





His Val Lys Pro Pro Pro His Ala Tyr Ser Ala Ala Leu Glu Pro Phe 

                245                 250                 255     





Phe Glu Ser Pro Leu Thr Asp Cys Thr Ser Pro Ser Phe Asp Gly Pro 

            260                 265                 270         





Leu Ser Pro Pro Leu Ser Ile Asn Gly Asn Phe Ser Phe Lys His Glu 

        275                 280                 285             





Pro Ser Ala Glu Phe Glu Lys Asn Tyr Ala Phe Thr Met His Tyr Pro 

    290                 295                 300                 





Ala Ala Thr Leu Ala Gly Pro Gln Ser His Gly Ser Ile Phe Ser Ser 

305                 310                 315                 320 





Gly Ala Ala Ala Pro Arg Cys Glu Ile Pro Ile Asp Asn Ile Met Ser 

                325                 330                 335     





Phe Asp Ser His Ser His His Glu Arg Val Met Ser Ala Gln Leu Asn 

            340                 345                 350         





Ala Ile Phe His Asp 

        355         





<210>  9

<211>  357

<212>  PRT

<213>  Mus musculus



<400>  9



Met Thr Lys Ser Tyr Ser Glu Ser Gly Leu Met Gly Glu Pro Gln Pro 

1               5                   10                  15      





Gln Gly Pro Pro Ser Trp Thr Asp Glu Cys Leu Ser Ser Gln Asp Glu 

            20                  25                  30          





Glu His Glu Ala Asp Lys Lys Glu Asp Glu Leu Glu Ala Met Asn Ala 

        35                  40                  45              





Glu Glu Asp Ser Leu Arg Asn Gly Gly Glu Glu Glu Glu Glu Asp Glu 

    50                  55                  60                  





Asp Leu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Asp Gln Lys 

65                  70                  75                  80  





Pro Lys Arg Arg Gly Pro Lys Lys Lys Lys Met Thr Lys Ala Arg Leu 

                85                  90                  95      





Glu Arg Phe Lys Leu Arg Arg Met Lys Ala Asn Ala Arg Glu Arg Asn 

            100                 105                 110         





Arg Met His Gly Leu Asn Ala Ala Leu Asp Asn Leu Arg Lys Val Val 

        115                 120                 125             





Pro Cys Tyr Ser Lys Thr Gln Lys Leu Ser Lys Ile Glu Thr Leu Arg 

    130                 135                 140                 





Leu Ala Lys Asn Tyr Ile Trp Ala Leu Ser Glu Ile Leu Arg Ser Gly 

145                 150                 155                 160 





Lys Ala Pro Asp Leu Val Ser Phe Val Gln Thr Leu Cys Lys Gly Leu 

                165                 170                 175     





Ser Gln Pro Thr Thr Asn Leu Val Ala Gly Cys Leu Gln Leu Asn Pro 

            180                 185                 190         





Arg Thr Phe Leu Pro Glu Gln Asn Pro Asp Met Pro Pro His Leu Pro 

        195                 200                 205             





Thr Ala Ser Ala Ser Phe Pro Val His Pro Tyr Ser Tyr Gln Ala Pro 

    210                 215                 220                 





Gly Leu Pro Ala Pro Pro Tyr Gly Thr Met Asp Ser Ser His Val Phe 

225                 230                 235                 240 





His Val Lys Pro Pro Pro His Ala Tyr Ser Ala Ala Leu Glu Pro Phe 

                245                 250                 255     





Phe Glu Ala Pro Leu Thr Asp Cys Thr Ala Pro Ser Phe Asp Gly Pro 

            260                 265                 270         





Leu Ala Pro Pro Leu Ser Ile Asn Gly Asn Phe Ser Phe Lys His Glu 

        275                 280                 285             





Pro Ser Ala Glu Phe Glu Lys Asn Tyr Ala Phe Thr Met His Tyr Pro 

    290                 295                 300                 





Ala Ala Thr Leu Ala Gly Pro Gln Ser His Gly Ser Ile Phe Ser Ser 

305                 310                 315                 320 





Gly Ala Ala Ala Pro Arg Cys Glu Ile Pro Ile Asp Asn Ile Met Ser 

                325                 330                 335     





Phe Asp Ser His Ser His His Glu Arg Val Met Ser Ala Gln Leu Asn 

            340                 345                 350         





Ala Ile Phe His Asp 

        355         





<210>  10

<211>  1074

<212>  DNA

<213>  Mus musculus



<400>  10

atgaccaaat catacagcga gagcgggctg atgggcgagc ctcagcccca aggtccccca       60



agctggacag atgagtgtct cagttctcag gacgaggaac acgaggcaga caagaaagag      120



gacgagcttg aagccatgaa tgcagaggag gactctctga gaaacggggg agaggaggag      180



gaggaagatg aggatctaga ggaagaggag gaagaagaag aggaggagga ggatcaaaag      240



cccaagagac ggggtcccaa aaagaaaaag atgaccaagg cgcgcctaga acgttttaaa      300



ttaaggcgca tgaaggccaa cgcccgcgag cggaaccgca tgcacgggct gaacgcggcg      360



ctggacaacc tgcgcaaggt ggtaccttgc tactccaaga cccagaaact gtctaaaata      420



gagacactgc gcttggccaa gaactacatc tgggctctgt cagagatcct gcgctcaggc      480



aaagcccctg atctggtctc cttcgtacag acgctctgca aaggtttgtc ccagcccact      540



accaatttgg tcgccggctg cctgcagctc aaccctcgga ctttcttgcc tgagcagaac      600



ccggacatgc ccccgcatct gccaaccgcc agcgcttcct tcccggtgca tccctactcc      660



taccaggccc ctggactgcc cgccccgccc tacggcacca tggacagctc ccacgtcttc      720



cacgtcaagc cgccgccaca cgcctacagc gcagctctgg agcccttctt tgaagccccc      780



ctaactgact gcaccgcccc ttcctttgac ggacccctcg ccccgccgct cagcatcaat      840



ggcaacttct ctttcaaaca cgaaccatcc gccgagtttg aaaaaaatta tgcctttacc      900



atgcactacc ctgcagcgac gctggcaggg ccccaaagcc acggatcaat cttctcttcc      960



ggtgccgctg cccctcgctg cgagatcccc atagacaaca ttatgtcttt cgatagccat     1020



tcgcatcatg agcgagtcat gagtgcccag cttaatgcca tctttcacga ttag           1074





<210>  11

<211>  357

<212>  PRT

<213>  Mus musculus



<400>  11



Met Thr Lys Ser Tyr Ser Glu Ser Gly Leu Met Gly Glu Pro Gln Pro 

1               5                   10                  15      





Gln Gly Pro Pro Ser Trp Thr Asp Glu Cys Leu Ser Ser Gln Asp Glu 

            20                  25                  30          





Glu His Glu Ala Asp Lys Lys Glu Asp Glu Leu Glu Ala Met Asn Ala 

        35                  40                  45              





Glu Glu Asp Ser Leu Arg Asn Gly Gly Glu Glu Glu Glu Glu Asp Glu 

    50                  55                  60                  





Asp Leu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Asp Gln Lys 

65                  70                  75                  80  





Pro Lys Arg Arg Gly Pro Lys Lys Lys Lys Met Thr Lys Ala Arg Leu 

                85                  90                  95      





Glu Arg Phe Lys Leu Arg Arg Met Lys Ala Asn Ala Arg Glu Arg Asn 

            100                 105                 110         





Arg Met His Gly Leu Asn Ala Ala Leu Asp Asn Leu Arg Lys Val Val 

        115                 120                 125             





Pro Cys Tyr Ser Lys Thr Gln Lys Leu Ala Lys Ile Glu Thr Leu Arg 

    130                 135                 140                 





Leu Ala Lys Asn Tyr Ile Trp Ala Leu Ser Glu Ile Leu Arg Ser Gly 

145                 150                 155                 160 





Lys Ala Pro Asp Leu Val Ser Phe Val Gln Thr Leu Cys Lys Gly Leu 

                165                 170                 175     





Ser Gln Pro Thr Thr Asn Leu Val Ala Gly Cys Leu Gln Leu Asn Pro 

            180                 185                 190         





Arg Thr Phe Leu Pro Glu Gln Asn Pro Asp Met Pro Pro His Leu Pro 

        195                 200                 205             





Thr Ala Ser Ala Ser Phe Pro Val His Pro Tyr Ser Tyr Gln Ala Pro 

    210                 215                 220                 





Gly Leu Pro Ala Pro Pro Tyr Gly Thr Met Asp Ser Ser His Val Phe 

225                 230                 235                 240 





His Val Lys Pro Pro Pro His Ala Tyr Ser Ala Ala Leu Glu Pro Phe 

                245                 250                 255     





Phe Glu Ala Pro Leu Thr Asp Cys Thr Ala Pro Ser Phe Asp Gly Pro 

            260                 265                 270         





Leu Ala Pro Pro Leu Ser Ile Asn Gly Asn Phe Ser Phe Lys His Glu 

        275                 280                 285             





Pro Ser Ala Glu Phe Glu Lys Asn Tyr Ala Phe Thr Met His Tyr Pro 

    290                 295                 300                 





Ala Ala Thr Leu Ala Gly Pro Gln Ser His Gly Ser Ile Phe Ser Ser 

305                 310                 315                 320 





Gly Ala Ala Ala Pro Arg Cys Glu Ile Pro Ile Asp Asn Ile Met Ser 

                325                 330                 335     





Phe Asp Ser His Ser His His Glu Arg Val Met Ser Ala Gln Leu Asn 

            340                 345                 350         





Ala Ile Phe His Asp 

        355         





<210>  12

<211>  1074

<212>  DNA

<213>  Mus musculus



<400>  12

atgaccaaat catacagcga gagcgggctg atgggcgagc ctcagcccca aggtccccca       60



agctggacag atgagtgtct cagttctcag gacgaggaac acgaggcaga caagaaagag      120



gacgagcttg aagccatgaa tgcagaggag gactctctga gaaacggggg agaggaggag      180



gaggaagatg aggatctaga ggaagaggag gaagaagaag aggaggagga ggatcaaaag      240



cccaagagac ggggtcccaa aaagaaaaag atgaccaagg cgcgcctaga acgttttaaa      300



ttaaggcgca tgaaggccaa cgcccgcgag cggaaccgca tgcacgggct gaacgcggcg      360



ctggacaacc tgcgcaaggt ggtaccttgc tactccaaga cccagaaact ggctaaaata      420



gagacactgc gcttggccaa gaactacatc tgggctctgt cagagatcct gcgctcaggc      480



aaagcccctg atctggtctc cttcgtacag acgctctgca aaggtttgtc ccagcccact      540



accaatttgg tcgccggctg cctgcagctc aaccctcgga ctttcttgcc tgagcagaac      600



ccggacatgc ccccgcatct gccaaccgcc agcgcttcct tcccggtgca tccctactcc      660



taccaggccc ctggactgcc cgccccgccc tacggcacca tggacagctc ccacgtcttc      720



cacgtcaagc cgccgccaca cgcctacagc gcagctctgg agcccttctt tgaagccccc      780



ctaactgact gcaccgcccc ttcctttgac ggacccctcg ccccgccgct cagcatcaat      840



ggcaacttct ctttcaaaca cgaaccatcc gccgagtttg aaaaaaatta tgcctttacc      900



atgcactacc ctgcagcgac gctggcaggg ccccaaagcc acggatcaat cttctcttcc      960



ggtgccgctg cccctcgctg cgagatcccc atagacaaca ttatgtcttt cgatagccat     1020



tcgcatcatg agcgagtcat gagtgcccag cttaatgcca tctttcacga ttag           1074





<210>  13

<211>  331

<212>  PRT

<213>  Homo sapiens



<400>  13



Met Ser Lys Thr Phe Val Lys Ser Lys Glu Met Gly Glu Leu Val Asn 

1               5                   10                  15      





Thr Pro Ser Trp Met Asp Lys Gly Leu Gly Ser Gln Asn Glu Val Lys 

            20                  25                  30          





Glu Glu Glu Ser Arg Pro Gly Thr Tyr Gly Met Leu Ser Ser Leu Thr 

        35                  40                  45              





Glu Glu His Asp Ser Ile Glu Glu Glu Glu Glu Glu Glu Glu Asp Gly 

    50                  55                  60                  





Glu Lys Pro Lys Arg Arg Gly Pro Lys Lys Lys Lys Met Thr Lys Ala 

65                  70                  75                  80  





Arg Leu Glu Arg Phe Arg Ala Arg Arg Val Lys Ala Asn Ala Arg Glu 

                85                  90                  95      





Arg Thr Arg Met His Gly Leu Asn Asp Ala Leu Asp Asn Leu Arg Arg 

            100                 105                 110         





Val Met Pro Cys Tyr Ser Lys Thr Gln Lys Leu Ser Lys Ile Glu Thr 

        115                 120                 125             





Leu Arg Leu Ala Arg Asn Tyr Ile Trp Ala Leu Ser Glu Val Leu Glu 

    130                 135                 140                 





Thr Gly Gln Thr Pro Glu Gly Lys Gly Phe Val Glu Met Leu Cys Lys 

145                 150                 155                 160 





Gly Leu Ser Gln Pro Thr Ser Asn Leu Val Ala Gly Cys Leu Gln Leu 

                165                 170                 175     





Gly Pro Gln Ser Val Leu Leu Glu Lys His Glu Asp Lys Ser Pro Ile 

            180                 185                 190         





Cys Asp Ser Ala Ile Ser Val His Asn Phe Asn Tyr Gln Ser Pro Gly 

        195                 200                 205             





Leu Pro Ser Pro Pro Tyr Gly His Met Glu Thr His Leu Leu His Leu 

    210                 215                 220                 





Lys Pro Gln Val Phe Lys Ser Leu Gly Glu Ser Ser Phe Gly Ser His 

225                 230                 235                 240 





Leu Pro Asp Cys Ser Thr Pro Pro Tyr Glu Gly Pro Leu Thr Pro Pro 

                245                 250                 255     





Leu Ser Ile Ser Gly Asn Phe Ser Leu Lys Gln Asp Gly Ser Pro Asp 

            260                 265                 270         





Leu Glu Lys Ser Tyr Ser Phe Met Pro His Tyr Pro Ser Ser Ser Leu 

        275                 280                 285             





Ser Ser Gly His Val His Ser Thr Pro Phe Gln Ala Gly Thr Pro Arg 

    290                 295                 300                 





Tyr Asp Val Pro Ile Asp Met Ser Tyr Asp Ser Tyr Pro His His Gly 

305                 310                 315                 320 





Ile Gly Thr Gln Leu Asn Thr Val Phe Thr Glu 

                325                 330     





<210>  14

<211>  330

<212>  PRT

<213>  Mus musculus



<400>  14



Met Ala Lys Met Tyr Met Lys Ser Lys Asp Met Val Glu Leu Val Asn 

1               5                   10                  15      





Thr Gln Ser Trp Met Asp Lys Gly Leu Ser Ser Gln Asn Glu Met Lys 

            20                  25                  30          





Glu Gln Glu Arg Arg Pro Gly Ser Tyr Gly Met Leu Gly Thr Leu Thr 

        35                  40                  45              





Glu Glu His Asp Ser Ile Glu Glu Asp Glu Glu Glu Glu Glu Asp Gly 

    50                  55                  60                  





Asp Lys Pro Lys Arg Arg Gly Pro Lys Lys Lys Lys Met Thr Lys Ala 

65                  70                  75                  80  





Arg Leu Glu Arg Phe Arg Ala Arg Arg Val Lys Ala Asn Ala Arg Glu 

                85                  90                  95      





Arg Thr Arg Met His Gly Leu Asn Asp Ala Leu Asp Asn Leu Arg Arg 

            100                 105                 110         





Val Met Pro Cys Tyr Ser Lys Thr Gln Lys Leu Ser Lys Ile Glu Thr 

        115                 120                 125             





Leu Arg Leu Ala Arg Asn Tyr Ile Trp Ala Leu Ser Glu Val Leu Glu 

    130                 135                 140                 





Thr Gly Gln Thr Leu Glu Gly Lys Gly Phe Val Glu Met Leu Cys Lys 

145                 150                 155                 160 





Gly Leu Ser Gln Pro Thr Ser Asn Leu Val Ala Gly Cys Leu Gln Leu 

                165                 170                 175     





Gly Pro Gln Ser Thr Leu Leu Glu Lys His Glu Glu Lys Ser Ser Ile 

            180                 185                 190         





Cys Asp Ser Thr Ile Ser Val His Ser Phe Asn Tyr Gln Ser Pro Gly 

        195                 200                 205             





Leu Pro Ser Pro Pro Tyr Gly His Met Glu Thr His Ser Leu His Leu 

    210                 215                 220                 





Lys Pro Gln Pro Phe Lys Ser Leu Gly Asp Ser Phe Gly Ser His Pro 

225                 230                 235                 240 





Pro Asp Cys Ser Thr Pro Pro Tyr Glu Gly Pro Leu Thr Pro Pro Leu 

                245                 250                 255     





Ser Ile Ser Gly Asn Phe Ser Leu Lys Gln Asp Gly Ser Pro Asp Leu 

            260                 265                 270         





Glu Lys Ser Tyr Asn Phe Met Pro His Tyr Thr Ser Ala Ser Leu Ser 

        275                 280                 285             





Ser Gly His Val His Ser Thr Pro Phe Gln Thr Gly Thr Pro Arg Tyr 

    290                 295                 300                 





Asp Val Pro Val Asp Leu Ser Tyr Asp Ser Tyr Ser His His Ser Ile 

305                 310                 315                 320 





Gly Thr Gln Leu Asn Thr Ile Phe Ser Asp 

                325                 330 





<210>  15

<211>  330

<212>  PRT

<213>  Mus musculus



<400>  15



Met Ala Lys Met Tyr Met Lys Ser Lys Asp Met Val Glu Leu Val Asn 

1               5                   10                  15      





Thr Gln Ser Trp Met Asp Lys Gly Leu Ser Ser Gln Asn Glu Met Lys 

            20                  25                  30          





Glu Gln Glu Arg Arg Pro Gly Ser Tyr Gly Met Leu Gly Thr Leu Thr 

        35                  40                  45              





Glu Glu His Asp Ser Ile Glu Glu Asp Glu Glu Glu Glu Glu Asp Gly 

    50                  55                  60                  





Asp Lys Pro Lys Arg Arg Gly Pro Lys Lys Lys Lys Met Thr Lys Ala 

65                  70                  75                  80  





Arg Leu Glu Arg Phe Arg Ala Arg Arg Val Lys Ala Asn Ala Arg Glu 

                85                  90                  95      





Arg Thr Arg Met His Gly Leu Asn Asp Ala Leu Asp Asn Leu Arg Arg 

            100                 105                 110         





Val Met Pro Cys Tyr Ser Lys Thr Gln Lys Leu Ser Lys Ile Glu Thr 

        115                 120                 125             





Leu Arg Leu Ala Arg Asn Tyr Ile Trp Ala Leu Ser Glu Val Leu Glu 

    130                 135                 140                 





Thr Gly Gln Thr Leu Glu Gly Lys Gly Phe Val Glu Met Leu Cys Lys 

145                 150                 155                 160 





Gly Leu Ser Gln Pro Thr Ser Asn Leu Val Ala Gly Cys Leu Gln Leu 

                165                 170                 175     





Gly Pro Gln Ser Thr Leu Leu Glu Lys His Glu Glu Lys Ser Ser Ile 

            180                 185                 190         





Cys Asp Ser Thr Ile Ser Val His Ser Phe Asn Tyr Gln Ala Pro Gly 

        195                 200                 205             





Leu Pro Ala Pro Pro Tyr Gly His Met Glu Thr His Ser Leu His Leu 

    210                 215                 220                 





Lys Pro Gln Pro Phe Lys Ser Leu Gly Asp Ser Phe Gly Ser His Pro 

225                 230                 235                 240 





Pro Asp Cys Ser Ala Pro Pro Tyr Glu Gly Pro Leu Ala Pro Pro Leu 

                245                 250                 255     





Ser Ile Ser Gly Asn Phe Ser Leu Lys Gln Asp Gly Ala Pro Asp Leu 

            260                 265                 270         





Glu Lys Ser Tyr Asn Phe Met Pro His Tyr Thr Ser Ala Ser Leu Ser 

        275                 280                 285             





Ser Gly His Val His Ser Ala Pro Phe Gln Thr Gly Ala Pro Arg Tyr 

    290                 295                 300                 





Asp Val Pro Val Asp Leu Ser Tyr Asp Ser Tyr Ser His His Ser Ile 

305                 310                 315                 320 





Gly Thr Gln Leu Asn Thr Ile Phe Ser Asp 

                325                 330 





<210>  16

<211>  993

<212>  DNA

<213>  Mus musculus



<400>  16

atggcaaaaa tgtatatgaa atccaaggac atggtggagc tggtcaacac acaatcctgg       60



atggacaaag gtctgagctc tcaaaatgag atgaaggagc aagagagaag accgggctct      120



tatggaatgc tcggaacctt aactgaagag catgacagta ttgaggagga tgaagaagag      180



gaagaagatg gagataaacc taaaagaaga ggtcccaaga aaaagaagat gactaaagct      240



cgccttgaaa gattcagggc tcgaagagtc aaggccaatg ctagagaacg gacccggatg      300



catggcctga atgatgcctt ggataatctt aggagagtca tgccatgtta ctctaaaact      360



caaaagcttt ccaagataga gactcttcga ctggcaagga actacatctg ggccttgtct      420



gaagtcctgg agactggtca gacacttgaa gggaagggat ttgtagagat gctatgtaaa      480



ggtctctctc aacccacaag caacctggtt gctggatgcc tccaactggg gcctcaatct      540



accctcctgg agaagcatga ggaaaaatct tcaatttgtg actctactat ctctgtccac      600



agcttcaact atcaggctcc agggctcccc gcccctcctt atggccatat ggaaacacat      660



tctctccatc tcaagcctca accatttaag agtttgggtg actcttttgg gagccatcca      720



cctgactgca gtgccccccc ttatgagggt ccactcgcac cacccctgag cattagtggc      780



aacttctcct taaagcaaga cggcgcccct gatttggaaa aatcctacaa tttcatgcca      840



cattatacct ctgcaagtct aagttcaggg catgtgcatt cagctccctt tcagactggc      900



gctccccgct atgatgttcc tgtagacctg agctatgatt cctactccca ccatagcatt      960



ggaactcagc tcaatacgat cttctctgat tag                                   993





<210>  17

<211>  330

<212>  PRT

<213>  Mus musculus



<400>  17



Met Ala Lys Met Tyr Met Lys Ser Lys Asp Met Val Glu Leu Val Asn 

1               5                   10                  15      





Thr Gln Ser Trp Met Asp Lys Gly Leu Ser Ser Gln Asn Glu Met Lys 

            20                  25                  30          





Glu Gln Glu Arg Arg Pro Gly Ser Tyr Gly Met Leu Gly Thr Leu Thr 

        35                  40                  45              





Glu Glu His Asp Ser Ile Glu Glu Asp Glu Glu Glu Glu Glu Asp Gly 

    50                  55                  60                  





Asp Lys Pro Lys Arg Arg Gly Pro Lys Lys Lys Lys Met Thr Lys Ala 

65                  70                  75                  80  





Arg Leu Glu Arg Phe Arg Ala Arg Arg Val Lys Ala Asn Ala Arg Glu 

                85                  90                  95      





Arg Thr Arg Met His Gly Leu Asn Asp Ala Leu Asp Asn Leu Arg Arg 

            100                 105                 110         





Val Met Pro Cys Tyr Ser Lys Thr Gln Lys Leu Ala Lys Ile Glu Thr 

        115                 120                 125             





Leu Arg Leu Ala Arg Asn Tyr Ile Trp Ala Leu Ser Glu Val Leu Glu 

    130                 135                 140                 





Thr Gly Gln Thr Leu Glu Gly Lys Gly Phe Val Glu Met Leu Cys Lys 

145                 150                 155                 160 





Gly Leu Ser Gln Pro Thr Ser Asn Leu Val Ala Gly Cys Leu Gln Leu 

                165                 170                 175     





Gly Pro Gln Ser Thr Leu Leu Glu Lys His Glu Glu Lys Ser Ser Ile 

            180                 185                 190         





Cys Asp Ser Thr Ile Ser Val His Ser Phe Asn Tyr Gln Ala Pro Gly 

        195                 200                 205             





Leu Pro Ala Pro Pro Tyr Gly His Met Glu Thr His Ser Leu His Leu 

    210                 215                 220                 





Lys Pro Gln Pro Phe Lys Ser Leu Gly Asp Ser Phe Gly Ser His Pro 

225                 230                 235                 240 





Pro Asp Cys Ser Ala Pro Pro Tyr Glu Gly Pro Leu Ala Pro Pro Leu 

                245                 250                 255     





Ser Ile Ser Gly Asn Phe Ser Leu Lys Gln Asp Gly Ala Pro Asp Leu 

            260                 265                 270         





Glu Lys Ser Tyr Asn Phe Met Pro His Tyr Thr Ser Ala Ser Leu Ser 

        275                 280                 285             





Ser Gly His Val His Ser Ala Pro Phe Gln Thr Gly Ala Pro Arg Tyr 

    290                 295                 300                 





Asp Val Pro Val Asp Leu Ser Tyr Asp Ser Tyr Ser His His Ser Ile 

305                 310                 315                 320 





Gly Thr Gln Leu Asn Thr Ile Phe Ser Asp 

                325                 330 





<210>  18

<211>  993

<212>  DNA

<213>  Mus musculus



<400>  18

atggcaaaaa tgtatatgaa atccaaggac atggtggagc tggtcaacac acaatcctgg       60



atggacaaag gtctgagctc tcaaaatgag atgaaggagc aagagagaag accgggctct      120



tatggaatgc tcggaacctt aactgaagag catgacagta ttgaggagga tgaagaagag      180



gaagaagatg gagataaacc taaaagaaga ggtcccaaga aaaagaagat gactaaagct      240



cgccttgaaa gattcagggc tcgaagagtc aaggccaatg ctagagaacg gacccggatg      300



catggcctga atgatgcctt ggataatctt aggagagtca tgccatgtta ctctaaaact      360



caaaagcttg ccaagataga gactcttcga ctggcaagga actacatctg ggccttgtct      420



gaagtcctgg agactggtca gacacttgaa gggaagggat ttgtagagat gctatgtaaa      480



ggtctctctc aacccacaag caacctggtt gctggatgcc tccaactggg gcctcaatct      540



accctcctgg agaagcatga ggaaaaatct tcaatttgtg actctactat ctctgtccac      600



agcttcaact atcaggctcc agggctcccc gcccctcctt atggccatat ggaaacacat      660



tctctccatc tcaagcctca accatttaag agtttgggtg actcttttgg gagccatcca      720



cctgactgca gtgccccccc ttatgagggt ccactcgcac cacccctgag cattagtggc      780



aacttctcct taaagcaaga cggcgcccct gatttggaaa aatcctacaa tttcatgcca      840



cattatacct ctgcaagtct aagttcaggg catgtgcatt cagctccctt tcagactggc      900



gctccccgct atgatgttcc tgtagacctg agctatgatt cctactccca ccatagcatt      960



ggaactcagc tcaatacgat cttctctgat tag                                   993





<210>  19

<211>  272

<212>  PRT

<213>  Homo sapiens



<400>  19



Met Phe Val Lys Ser Glu Thr Leu Glu Leu Lys Glu Glu Glu Asp Val 

1               5                   10                  15      





Leu Val Leu Leu Gly Ser Ala Ser Pro Ala Leu Ala Ala Leu Thr Pro 

            20                  25                  30          





Leu Ser Ser Ser Ala Asp Glu Glu Glu Glu Glu Glu Pro Gly Ala Ser 

        35                  40                  45              





Gly Gly Ala Arg Arg Gln Arg Gly Ala Glu Ala Gly Gln Gly Ala Arg 

    50                  55                  60                  





Gly Gly Val Ala Ala Gly Ala Glu Gly Cys Arg Pro Ala Arg Leu Leu 

65                  70                  75                  80  





Gly Leu Val His Asp Cys Lys Arg Arg Pro Ser Arg Ala Arg Ala Val 

                85                  90                  95      





Ser Arg Gly Ala Lys Thr Ala Glu Thr Val Gln Arg Ile Lys Lys Thr 

            100                 105                 110         





Arg Arg Leu Lys Ala Asn Asn Arg Glu Arg Asn Arg Met His Asn Leu 

        115                 120                 125             





Asn Ala Ala Leu Asp Ala Leu Arg Glu Val Leu Pro Thr Phe Pro Glu 

    130                 135                 140                 





Asp Ala Lys Leu Thr Lys Ile Glu Thr Leu Arg Phe Ala His Asn Tyr 

145                 150                 155                 160 





Ile Trp Ala Leu Thr Glu Thr Leu Arg Leu Ala Asp His Cys Gly Gly 

                165                 170                 175     





Gly Gly Gly Gly Leu Pro Gly Ala Leu Phe Ser Glu Ala Val Leu Leu 

            180                 185                 190         





Ser Pro Gly Gly Ala Ser Ala Ala Leu Ser Ser Ser Gly Asp Ser Pro 

        195                 200                 205             





Ser Pro Ala Ser Thr Trp Ser Cys Thr Asn Ser Pro Ala Pro Ser Ser 

    210                 215                 220                 





Ser Val Ser Ser Asn Ser Thr Ser Pro Tyr Ser Cys Thr Leu Ser Pro 

225                 230                 235                 240 





Ala Ser Pro Ala Gly Ser Asp Met Asp Tyr Trp Gln Pro Pro Pro Pro 

                245                 250                 255     





Asp Lys His Arg Tyr Ala Pro His Leu Pro Ile Ala Arg Asp Cys Ile 

            260                 265                 270         





<210>  20

<211>  263

<212>  PRT

<213>  Mus musculus



<400>  20



Met Phe Val Lys Ser Glu Thr Leu Glu Leu Lys Glu Glu Glu Glu Val 

1               5                   10                  15      





Leu Met Leu Leu Gly Ser Ala Ser Pro Ala Ser Ala Thr Leu Thr Pro 

            20                  25                  30          





Met Ser Ser Ser Ala Asp Glu Glu Glu Asp Glu Glu Leu Arg Arg Pro 

        35                  40                  45              





Gly Ser Ala Arg Gly Gln Arg Gly Ala Glu Ala Gly Gln Gly Val Gln 

    50                  55                  60                  





Gly Ser Pro Ala Ser Gly Ala Gly Gly Cys Arg Pro Gly Arg Leu Leu 

65                  70                  75                  80  





Gly Leu Met His Glu Cys Lys Arg Arg Pro Ser Arg Ser Arg Ala Val 

                85                  90                  95      





Ser Arg Gly Ala Lys Thr Ala Glu Thr Val Gln Arg Ile Lys Lys Thr 

            100                 105                 110         





Arg Arg Leu Lys Ala Asn Asn Arg Glu Arg Asn Arg Met His Asn Leu 

        115                 120                 125             





Asn Ala Ala Leu Asp Ala Leu Arg Glu Val Leu Pro Thr Phe Pro Glu 

    130                 135                 140                 





Asp Ala Lys Leu Thr Lys Ile Glu Thr Leu Arg Phe Ala His Asn Tyr 

145                 150                 155                 160 





Ile Trp Ala Leu Thr Glu Thr Leu Arg Leu Ala Asp His Cys Ala Gly 

                165                 170                 175     





Ala Gly Gly Leu Gln Gly Ala Leu Phe Thr Glu Ala Val Leu Leu Ser 

            180                 185                 190         





Pro Gly Ala Ala Leu Gly Ala Ser Gly Asp Ser Pro Ser Pro Pro Ser 

        195                 200                 205             





Ser Trp Ser Cys Thr Asn Ser Pro Ala Ser Ser Ser Asn Ser Thr Ser 

    210                 215                 220                 





Pro Tyr Ser Cys Thr Leu Ser Pro Ala Ser Pro Gly Ser Asp Val Asp 

225                 230                 235                 240 





Tyr Trp Gln Pro Pro Pro Pro Glu Lys His Arg Tyr Ala Pro His Leu 

                245                 250                 255     





Pro Leu Ala Arg Asp Cys Ile 

            260             





<210>  21

<211>  263

<212>  PRT

<213>  Mus musculus



<400>  21



Met Phe Val Lys Ser Glu Thr Leu Glu Leu Lys Glu Glu Glu Glu Val 

1               5                   10                  15      





Leu Met Leu Leu Gly Ser Ala Ala Pro Ala Ser Ala Thr Leu Ala Pro 

            20                  25                  30          





Met Ser Ser Ser Ala Asp Glu Glu Glu Asp Glu Glu Leu Arg Arg Pro 

        35                  40                  45              





Gly Ser Ala Arg Gly Gln Arg Gly Ala Glu Ala Gly Gln Gly Val Gln 

    50                  55                  60                  





Gly Ala Pro Ala Ser Gly Ala Gly Gly Cys Arg Pro Gly Arg Leu Leu 

65                  70                  75                  80  





Gly Leu Met His Glu Cys Lys Arg Arg Pro Ser Arg Ser Arg Ala Val 

                85                  90                  95      





Ser Arg Gly Ala Lys Thr Ala Glu Thr Val Gln Arg Ile Lys Lys Thr 

            100                 105                 110         





Arg Arg Leu Lys Ala Asn Asn Arg Glu Arg Asn Arg Met His Asn Leu 

        115                 120                 125             





Asn Ala Ala Leu Asp Ala Leu Arg Glu Val Leu Pro Thr Phe Pro Glu 

    130                 135                 140                 





Asp Ala Lys Leu Thr Lys Ile Glu Thr Leu Arg Phe Ala His Asn Tyr 

145                 150                 155                 160 





Ile Trp Ala Leu Thr Glu Thr Leu Arg Leu Ala Asp His Cys Ala Gly 

                165                 170                 175     





Ala Gly Gly Leu Gln Gly Ala Leu Phe Thr Glu Ala Val Leu Leu Ala 

            180                 185                 190         





Pro Gly Ala Ala Leu Gly Ala Ser Gly Asp Ala Pro Ala Pro Pro Ser 

        195                 200                 205             





Ser Trp Ser Cys Thr Asn Ala Pro Ala Ser Ser Ser Asn Ser Thr Ala 

    210                 215                 220                 





Pro Tyr Ser Cys Thr Leu Ala Pro Ala Ala Pro Gly Ser Asp Val Asp 

225                 230                 235                 240 





Tyr Trp Gln Pro Pro Pro Pro Glu Lys His Arg Tyr Ala Pro His Leu 

                245                 250                 255     





Pro Leu Ala Arg Asp Cys Ile 

            260             





<210>  22

<211>  792

<212>  DNA

<213>  Mus musculus



<400>  22

atgttcgtca aatctgagac tctggagttg aaggaggaag aggaggtact gatgctgctg       60



ggctcggctg ccccggcctc ggcgaccctg gccccgatgt cctccagcgc ggacgaggag      120



gaggacgagg agctgcgccg gccgggctcc gcgcgtgggc agcgtggagc ggaagccggg      180



cagggggtgc agggcgctcc ggcgtcgggt gccgggggtt gccggccagg gcggctgctg      240



ggcctgatgc acgagtgcaa gcgtcgcccg tcgcgctcac gggccgtctc ccgaggtgcc      300



aagacggcgg agacggtgca gcgcatcaag aagacccgca ggctcaaggc caacaaccgc      360



gagcgcaacc gcatgcacaa cctaaacgcc gcgctggacg cgctgcgcga ggtgctgccc      420



accttccccg aggatgccaa gctcacgaag atcgagacgc tgcgcttcgc ccacaattac      480



atctgggcgc tcaccgagac tctgcgcctg gcggaccact gcgccggcgc cggtggcctc      540



cagggggcgc tcttcacgga ggcggtgctc ctggccccgg gagctgcgct cggcgccagc      600



ggggacgccc ctgctccacc ttcctcctgg agctgcacca acgccccggc gtcatcctcc      660



aactccacgg ccccatacag ctgcacttta gcgcccgctg cccccgggtc agacgtggac      720



tactggcagc ccccacctcc ggagaagcat cgttatgcgc ctcacctgcc cctcgccagg      780



gactgtatct ag                                                          792





<210>  23

<211>  263

<212>  PRT

<213>  Mus musculus



<400>  23



Met Phe Val Lys Ser Glu Thr Leu Glu Leu Lys Glu Glu Glu Glu Val 

1               5                   10                  15      





Leu Met Leu Leu Gly Ser Ala Ala Pro Ala Ser Ala Thr Leu Ala Pro 

            20                  25                  30          





Met Ser Ser Ser Ala Asp Glu Glu Glu Asp Glu Glu Leu Arg Arg Pro 

        35                  40                  45              





Gly Ser Ala Arg Gly Gln Arg Gly Ala Glu Ala Gly Gln Gly Val Gln 

    50                  55                  60                  





Gly Ala Pro Ala Ser Gly Ala Gly Gly Cys Arg Pro Gly Arg Leu Leu 

65                  70                  75                  80  





Gly Leu Met His Glu Cys Lys Arg Arg Pro Ser Arg Ser Arg Ala Val 

                85                  90                  95      





Ser Arg Gly Ala Lys Thr Ala Glu Thr Val Gln Arg Ile Lys Lys Thr 

            100                 105                 110         





Arg Arg Leu Lys Ala Asn Asn Arg Glu Arg Asn Arg Met His Asn Leu 

        115                 120                 125             





Asn Ala Ala Leu Asp Ala Leu Arg Glu Val Leu Pro Thr Phe Pro Glu 

    130                 135                 140                 





Asp Ala Lys Leu Ala Lys Ile Glu Thr Leu Arg Phe Ala His Asn Tyr 

145                 150                 155                 160 





Ile Trp Ala Leu Thr Glu Thr Leu Arg Leu Ala Asp His Cys Ala Gly 

                165                 170                 175     





Ala Gly Gly Leu Gln Gly Ala Leu Phe Thr Glu Ala Val Leu Leu Ala 

            180                 185                 190         





Pro Gly Ala Ala Leu Gly Ala Ser Gly Asp Ala Pro Ala Pro Pro Ser 

        195                 200                 205             





Ser Trp Ser Cys Thr Asn Ala Pro Ala Ser Ser Ser Asn Ser Thr Ala 

    210                 215                 220                 





Pro Tyr Ser Cys Thr Leu Ala Pro Ala Ala Pro Gly Ser Asp Val Asp 

225                 230                 235                 240 





Tyr Trp Gln Pro Pro Pro Pro Glu Lys His Arg Tyr Ala Pro His Leu 

                245                 250                 255     





Pro Leu Ala Arg Asp Cys Ile 

            260             





<210>  24

<211>  792

<212>  DNA

<213>  Mus musculus



<400>  24

atgttcgtca aatctgagac tctggagttg aaggaggaag aggaggtact gatgctgctg       60



ggctcggctg ccccggcctc ggcgaccctg gccccgatgt cctccagcgc ggacgaggag      120



gaggacgagg agctgcgccg gccgggctcc gcgcgtgggc agcgtggagc ggaagccggg      180



cagggggtgc agggcgctcc ggcgtcgggt gccgggggtt gccggccagg gcggctgctg      240



ggcctgatgc acgagtgcaa gcgtcgcccg tcgcgctcac gggccgtctc ccgaggtgcc      300



aagacggcgg agacggtgca gcgcatcaag aagacccgca ggctcaaggc caacaaccgc      360



gagcgcaacc gcatgcacaa cctaaacgcc gcgctggacg cgctgcgcga ggtgctgccc      420



accttccccg aggatgccaa gctcgcgaag atcgagacgc tgcgcttcgc ccacaattac      480



atctgggcgc tcaccgagac tctgcgcctg gcggaccact gcgccggcgc cggtggcctc      540



cagggggcgc tcttcacgga ggcggtgctc ctggccccgg gagctgcgct cggcgccagc      600



ggggacgccc ctgctccacc ttcctcctgg agctgcacca acgccccggc gtcatcctcc      660



aactccacgg ccccatacag ctgcacttta gcgcccgctg cccccgggtc agacgtggac      720



tactggcagc ccccacctcc ggagaagcat cgttatgcgc ctcacctgcc cctcgccagg      780



gactgtatct ag                                                          792





<210>  25

<211>  263

<212>  PRT

<213>  Mus musculus



<400>  25



Met Phe Val Lys Ser Glu Thr Leu Glu Leu Lys Glu Glu Glu Glu Val 

1               5                   10                  15      





Leu Met Leu Leu Gly Ser Ala Ala Pro Ala Ser Ala Thr Leu Thr Pro 

            20                  25                  30          





Met Ser Ser Ser Ala Asp Glu Glu Glu Asp Glu Glu Leu Arg Arg Pro 

        35                  40                  45              





Gly Ser Ala Arg Gly Gln Arg Gly Ala Glu Ala Gly Gln Gly Val Gln 

    50                  55                  60                  





Gly Ala Pro Ala Ser Gly Ala Gly Gly Cys Arg Pro Gly Arg Leu Leu 

65                  70                  75                  80  





Gly Leu Met His Glu Cys Lys Arg Arg Pro Ser Arg Ser Arg Ala Val 

                85                  90                  95      





Ser Arg Gly Ala Lys Thr Ala Glu Thr Val Gln Arg Ile Lys Lys Thr 

            100                 105                 110         





Arg Arg Leu Lys Ala Asn Asn Arg Glu Arg Asn Arg Met His Asn Leu 

        115                 120                 125             





Asn Ala Ala Leu Asp Ala Leu Arg Glu Val Leu Pro Thr Phe Pro Glu 

    130                 135                 140                 





Asp Ala Lys Leu Thr Lys Ile Glu Thr Leu Arg Phe Ala His Asn Tyr 

145                 150                 155                 160 





Ile Trp Ala Leu Thr Glu Thr Leu Arg Leu Ala Asp His Cys Ala Gly 

                165                 170                 175     





Ala Gly Gly Leu Gln Gly Ala Leu Phe Thr Glu Ala Val Leu Leu Ala 

            180                 185                 190         





Pro Gly Ala Ala Leu Gly Ala Ser Gly Asp Ala Pro Ala Pro Pro Ser 

        195                 200                 205             





Ser Trp Ser Cys Thr Asn Ala Pro Ala Ser Ser Ser Asn Ser Thr Ala 

    210                 215                 220                 





Pro Tyr Ser Cys Thr Leu Ala Pro Ala Ala Pro Gly Ser Asp Val Asp 

225                 230                 235                 240 





Tyr Trp Gln Pro Pro Pro Pro Glu Lys His Arg Tyr Ala Pro His Leu 

                245                 250                 255     





Pro Leu Ala Arg Asp Cys Ile 

            260             





<210>  26

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Primer



<400>  26

catcagccct aatccatctg a                                                 21





<210>  27

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Primer



<400>  27

cgcgactaac aatcaaagtg a                                                 21





<210>  28

<211>  17

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Primer



<400>  28

ctggcttctg aggaccg                                                      17





<210>  29

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Primer



<400>  29

aatctgtggg aagtcttgtc c                                                 21





<210>  30

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Primer



<400>  30

accagaagtg gcacctgac                                                    19





<210>  31

<211>  24

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Primer



<400>  31

caaattttgt aatccagagg ttga                                              24





<210>  32

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Primer



<400>  32

ggcattaaag cagcgtatcc                                                   20





<210>  33

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Primer



<400>  33

ctgttcctgt acggcatgg                                                    19





<210>  34

<211>  24

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Primer



<400>  34

ctaggccaca gaattgaaag atct                                              24





<210>  35

<211>  22

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Primer



<400>  35

gtaggtggaa attctagcat cc                                                22





<210>  36

<211>  531

<212>  PRT

<213>  Mus musculus



<400>  36



Met Cys Pro Lys Gly Tyr Glu Asp Ser Met Glu Phe Pro Asp His Ser 

1               5                   10                  15      





Arg His Leu Leu Gln Cys Leu Ser Glu Gln Arg His Gln Gly Phe Leu 

            20                  25                  30          





Cys Asp Cys Thr Val Leu Val Gly Asp Ala Gln Phe Arg Ala His Arg 

        35                  40                  45              





Ala Val Leu Ala Ser Cys Ser Met Tyr Phe His Leu Phe Tyr Lys Asp 

    50                  55                  60                  





Gln Leu Asp Lys Arg Asp Ile Val His Leu Asn Ser Asp Ile Val Thr 

65                  70                  75                  80  





Ala Pro Ala Phe Ala Leu Leu Leu Glu Phe Met Tyr Glu Gly Lys Leu 

                85                  90                  95      





Gln Phe Lys Asp Leu Pro Ile Glu Asp Val Leu Ala Ala Ala Ser Tyr 

            100                 105                 110         





Leu His Met Tyr Asp Ile Val Lys Val Cys Lys Lys Lys Leu Lys Glu 

        115                 120                 125             





Lys Ala Thr Thr Glu Ala Asp Ser Thr Lys Lys Glu Glu Asp Ala Ser 

    130                 135                 140                 





Ser Cys Ser Asp Lys Val Glu Ser Leu Ser Asp Gly Ser Ser His Met 

145                 150                 155                 160 





Ala Gly Asp Leu Pro Ser Asp Glu Asp Glu Gly Glu Asp Asp Lys Leu 

                165                 170                 175     





Asn Ile Leu Pro Ser Lys Arg Asp Leu Ala Ala Glu Pro Gly Asn Met 

            180                 185                 190         





Trp Met Arg Leu Pro Ser Asp Ser Ala Gly Ile Pro Gln Ala Gly Gly 

        195                 200                 205             





Glu Ala Glu Pro His Ala Thr Ala Ala Gly Lys Thr Val Ala Ser Pro 

    210                 215                 220                 





Cys Ser Ser Thr Glu Ser Leu Ser Gln Arg Ser Val Thr Ser Val Arg 

225                 230                 235                 240 





Asp Ser Ala Asp Val Asp Cys Val Leu Asp Leu Ser Val Lys Ser Ser 

                245                 250                 255     





Leu Ser Gly Val Glu Asn Leu Asn Ser Ser Tyr Phe Ser Ser Gln Asp 

            260                 265                 270         





Val Leu Arg Ser Asn Leu Val Gln Val Lys Val Glu Lys Glu Ala Ser 

        275                 280                 285             





Cys Asp Glu Ser Asp Val Gly Thr Asn Asp Tyr Asp Met Glu His Ser 

    290                 295                 300                 





Thr Val Lys Glu Ser Val Ser Thr Asn Asn Arg Val Gln Tyr Glu Pro 

305                 310                 315                 320 





Ala His Leu Ala Pro Leu Arg Glu Asp Ser Val Leu Arg Glu Leu Asp 

                325                 330                 335     





Arg Glu Asp Lys Ala Ser Asp Asp Glu Met Met Thr Pro Glu Ser Glu 

            340                 345                 350         





Arg Val Gln Val Glu Gly Gly Met Glu Asn Ser Leu Leu Pro Tyr Val 

        355                 360                 365             





Ser Asn Ile Leu Ser Pro Ala Gly Gln Ile Phe Met Cys Pro Leu Cys 

    370                 375                 380                 





Asn Lys Val Phe Pro Ser Pro His Ile Leu Gln Ile His Leu Ser Thr 

385                 390                 395                 400 





His Phe Arg Glu Gln Asp Gly Ile Arg Ser Lys Pro Ala Ala Asp Val 

                405                 410                 415     





Asn Val Pro Thr Cys Ser Leu Cys Gly Lys Thr Phe Ser Cys Met Tyr 

            420                 425                 430         





Thr Leu Lys Arg His Glu Arg Thr His Ser Gly Glu Lys Pro Tyr Thr 

        435                 440                 445             





Cys Thr Gln Cys Gly Lys Ser Phe Gln Tyr Ser His Asn Leu Ser Arg 

    450                 455                 460                 





His Ala Val Val His Thr Arg Glu Lys Pro His Ala Cys Lys Trp Cys 

465                 470                 475                 480 





Glu Arg Arg Phe Thr Gln Ser Gly Asp Leu Tyr Arg His Ile Arg Lys 

                485                 490                 495     





Phe His Cys Glu Leu Val Asn Ser Leu Ser Val Lys Ser Glu Ala Leu 

            500                 505                 510         





Ser Leu Pro Thr Val Arg Asp Trp Thr Leu Glu Asp Ser Ser Gln Glu 

        515                 520                 525             





Leu Trp Lys 

    530     





<210>  37

<211>  3848

<212>  DNA

<213>  Mus musculus



<400>  37

agtgtgtgcg gatctgtggt ggagaaggta tctcattcct ctccaacatc atctccactt       60



tgcatctgtc tctcttagtc tgcttttttt ccaccgatgt aacagacctg cagccagcaa      120



gactccgagg gaaggactta atcaagttta tgtgtcctaa aggttatgaa gacagtatgg      180



agtttccaga ccacagcaga catttgctgc agtgtctgag cgagcagagg caccagggct      240



ttctttgtga ctgcactgtt ctggtgggag atgcccagtt ccgggcacac cgagctgttc      300



tggcttcatg cagcatgtat ttccacctct tttacaagga ccagctggac aaaagagaca      360



ttgttcatct gaacagcgac attgtgacag cccccgcttt cgctctcctg cttgaattca      420



tgtacgaagg gaaactccag ttcaaagact tgcccattga ggacgtgcta gcagctgcca      480



gttatctcca catgtatgac attgtcaaag tctgcaaaaa gaagctgaaa gagaaagcta      540



ccacagaggc ggacagcacc aaaaaagaag aagatgcttc aagttgttcg gataaagtcg      600



agagcctctc agacggcagc agccacatgg caggtgacct gcccagtgat gaagatgaag      660



gcgaagatga caaattgaac attctaccca gcaaaaggga cttggcagct gagcctggga      720



acatgtggat gcgattgccc tcagactcag caggcatccc ccaggctggc ggagaggccg      780



agccacacgc cacagcagct ggaaaaacag tagccagccc ctgcagctca acagagtctt      840



tgtcccagag gtctgtcacc tccgtgaggg attcggcaga tgttgactgt gtgctggacc      900



tgtctgtcaa gtccagcctt tcaggagttg aaaatctgaa cagctcttat ttctcttcac      960



aggacgtgct gagaagcaac ctggtgcagg tgaaggtgga gaaagaggcg tcctgtgatg     1020



agagtgatgt tggcactaat gactatgaca tggaacatag cactgtgaaa gagagtgtga     1080



gcactaacaa cagggtacag tatgagccag cccacctggc tcctctgagg gaggactcgg     1140



tcttaaggga actggatcgg gaggacaaag ccagcgatga tgagatgatg accccagaga     1200



gcgagcgggt ccaggtggaa gggggcatgg agaacagtct gcttccctac gtctccaata     1260



tcctgagccc cgcaggccag atcttcatgt gccccctgtg caacaaagtc ttccccagcc     1320



cccacatcct gcagatccac ctgagcacgc acttccgaga gcaggatggc atccgtagca     1380



agcctgccgc cgatgtcaat gtgcccacgt gctccctgtg tgggaagact ttctcctgca     1440



tgtacaccct caagcgccac gagaggactc actcggggga gaagccctac acgtgcaccc     1500



aatgcggcaa gagtttccag tactcgcaca acctgagccg tcatgccgtg gtgcacaccc     1560



gcgagaagcc ccatgcctgc aagtggtgcg agcgcaggtt cacgcagtcc ggagacctgt     1620



acagacacat ccgcaagttc cactgtgagt tggtgaactc cttgtcggtc aaaagtgaag     1680



cgctgagctt gcccactgtc agagactgga ccttagaaga tagctctcaa gaactttgga     1740



aataatttta tatatatata tatataaata atatatatat atatatatac atatatatac     1800



atagatctct atatagttgt ggtacggtct aaaagcagtc ttgtttcctg gaactgaaaa     1860



gttgggatct taacttgttt ttgcacttta gaataatagc atgagaatct cactaattta     1920



gcattctgat aaaagaaact agagcaagtc acaagtagag agctgtcttt cttttgaggg     1980



ttaggccaag ttagccaata aaaccttctc aacaaatggt tctgtcacaa acgctttcac     2040



atggcttact tttgtacaca ctgcattgtc ttgagcgctt tccctgtgct ccacactgtt     2100



ttgttttgtt ttgttttcag agtagaaatc ccctccagtt tattagcctc tttatatgtc     2160



tcaaattgca tgaatatttt ctggctgttg gaaacctgaa tgcttttaga cccaaatgga     2220



aaatttctga aatgctggat tatctatttt taaacaagca gttgacttaa aactttgtgt     2280



ggcaacttct ggttttctga tggtccccag tgagagaaat ctgacagtac actgggtcac     2340



tgggactgtc tctgtgaagg tttgcttgag atgaaaaagg atattgcagc ttcagcagtg     2400



ttgaactgtg tgtttaaaat gtgaattact gttcttgtat actgtaattg attacacggg     2460



ctgggggggg tgtcaaagaa cttgacaggt tgtgttgatg ctcttagttg agtcttgaaa     2520



agtaaatatt aacgctacag aaatgcatga gtttcaatat attttttgtc tttgtttgca     2580



ttgtataact ttaacgagtg agtttaaaat tatttaattt ccttagaaaa atagcaccat     2640



ttgggaaaaa aactggtgtt acgaagaaca taaatgcact gtctttattt ttatttttat     2700



tttatataat ttaaattgac ttttcccacg tctttaagtt tgaaactgtt aagctgaata     2760



aaaacttaag ctgcaaattg ataacttcgc tacattacaa ggaacatata aatgtttaca     2820



aacggcttaa agaattgcat gtgcagtgtg cattcatacc acacttgtaa ttgcacagaa     2880



cccatgccag ctcagagttt aggtgtacac acgtacccag ccgagtgttt ttagaataac     2940



tactgcacaa attgacaata ggtcataggt cattctctct ctccctcctt tttgcttccc     3000



ctttcttttt ctcccctatt tcctttcctt ccccctaccc cctaactcat gaaaagattc     3060



tatggactga aaaagcccca ggctgaaagg actgaaccgc cttgattgac atggggaggg     3120



gggttagtag actgtgtatc ggcagcagag gctgcagccc gatgtgtggt tctgatggcc     3180



agcgcggggc agaagcgttt tgcacactgt ttgttttcct gtcttgcact tacaaataag     3240



gtctatggga gtagcatggg aaacagtggt tgtttttccc tttttctttt ttaattgctt     3300



ttgtttaaaa tttgatcgcc ttaactactg taaacatagc ctatttttgt gcttaagata     3360



ctgaatggaa aactccattg tgtgttgctg gactgttttg gaaatatttg gtcaaatgta     3420



tgttaatttg gctgtaatgg catttaaagc aaacaaacaa acaaacaaac aaagctgtga     3480



aaatggcctt ggagcattat ctttagttac ttgaagagtt tctagttttt ttttttttaa     3540



tacagtttat gttaaaataa tctttattaa tctagaggag acaatcaatg tctgtggaag     3600



aacggacttt tttggatttt cttttttaat ggtcattgtg agtgattgct ctttctttta     3660



cttagtttca cattcttcct ttgttctaaa tcttagactg acatctagct ttgacaatca     3720



tagtatgttt tatttcctga gggggaataa cttataatgc tgtttagttt tgtactattg     3780



gtgtgttggt gaatttttaa actgtgtgct aactgcaata aattatatga actgagaaaa     3840



aaaaaaaa                                                              3848





<210>  38

<211>  522

<212>  PRT

<213>  Mus musculus



<400>  38



Met Glu Phe Pro Asp His Ser Arg His Leu Leu Gln Cys Leu Ser Glu 

1               5                   10                  15      





Gln Arg His Gln Gly Phe Leu Cys Asp Cys Thr Val Leu Val Gly Asp 

            20                  25                  30          





Ala Gln Phe Arg Ala His Arg Ala Val Leu Ala Ser Cys Ser Met Tyr 

        35                  40                  45              





Phe His Leu Phe Tyr Lys Asp Gln Leu Asp Lys Arg Asp Ile Val His 

    50                  55                  60                  





Leu Asn Ser Asp Ile Val Thr Ala Pro Ala Phe Ala Leu Leu Leu Glu 

65                  70                  75                  80  





Phe Met Tyr Glu Gly Lys Leu Gln Phe Lys Asp Leu Pro Ile Glu Asp 

                85                  90                  95      





Val Leu Ala Ala Ala Ser Tyr Leu His Met Tyr Asp Ile Val Lys Val 

            100                 105                 110         





Cys Lys Lys Lys Leu Lys Glu Lys Ala Thr Thr Glu Ala Asp Ser Thr 

        115                 120                 125             





Lys Lys Glu Glu Asp Ala Ser Ser Cys Ser Asp Lys Val Glu Ser Leu 

    130                 135                 140                 





Ser Asp Gly Ser Ser His Met Ala Gly Asp Leu Pro Ser Asp Glu Asp 

145                 150                 155                 160 





Glu Gly Glu Asp Asp Lys Leu Asn Ile Leu Pro Ser Lys Arg Asp Leu 

                165                 170                 175     





Ala Ala Glu Pro Gly Asn Met Trp Met Arg Leu Pro Ser Asp Ser Ala 

            180                 185                 190         





Gly Ile Pro Gln Ala Gly Gly Glu Ala Glu Pro His Ala Thr Ala Ala 

        195                 200                 205             





Gly Lys Thr Val Ala Ser Pro Cys Ser Ser Thr Glu Ser Leu Ser Gln 

    210                 215                 220                 





Arg Ser Val Thr Ser Val Arg Asp Ser Ala Asp Val Asp Cys Val Leu 

225                 230                 235                 240 





Asp Leu Ser Val Lys Ser Ser Leu Ser Gly Val Glu Asn Leu Asn Ser 

                245                 250                 255     





Ser Tyr Phe Ser Ser Gln Asp Val Leu Arg Ser Asn Leu Val Gln Val 

            260                 265                 270         





Lys Val Glu Lys Glu Ala Ser Cys Asp Glu Ser Asp Val Gly Thr Asn 

        275                 280                 285             





Asp Tyr Asp Met Glu His Ser Thr Val Lys Glu Ser Val Ser Thr Asn 

    290                 295                 300                 





Asn Arg Val Gln Tyr Glu Pro Ala His Leu Ala Pro Leu Arg Glu Asp 

305                 310                 315                 320 





Ser Val Leu Arg Glu Leu Asp Arg Glu Asp Lys Ala Ser Asp Asp Glu 

                325                 330                 335     





Met Met Thr Pro Glu Ser Glu Arg Val Gln Val Glu Gly Gly Met Glu 

            340                 345                 350         





Asn Ser Leu Leu Pro Tyr Val Ser Asn Ile Leu Ser Pro Ala Gly Gln 

        355                 360                 365             





Ile Phe Met Cys Pro Leu Cys Asn Lys Val Phe Pro Ser Pro His Ile 

    370                 375                 380                 





Leu Gln Ile His Leu Ser Thr His Phe Arg Glu Gln Asp Gly Ile Arg 

385                 390                 395                 400 





Ser Lys Pro Ala Ala Asp Val Asn Val Pro Thr Cys Ser Leu Cys Gly 

                405                 410                 415     





Lys Thr Phe Ser Cys Met Tyr Thr Leu Lys Arg His Glu Arg Thr His 

            420                 425                 430         





Ser Gly Glu Lys Pro Tyr Thr Cys Thr Gln Cys Gly Lys Ser Phe Gln 

        435                 440                 445             





Tyr Ser His Asn Leu Ser Arg His Ala Val Val His Thr Arg Glu Lys 

    450                 455                 460                 





Pro His Ala Cys Lys Trp Cys Glu Arg Arg Phe Thr Gln Ser Gly Asp 

465                 470                 475                 480 





Leu Tyr Arg His Ile Arg Lys Phe His Cys Glu Leu Val Asn Ser Leu 

                485                 490                 495     





Ser Val Lys Ser Glu Ala Leu Ser Leu Pro Thr Val Arg Asp Trp Thr 

            500                 505                 510         





Leu Glu Asp Ser Ser Gln Glu Leu Trp Lys 

        515                 520         





<210>  39

<211>  4954

<212>  DNA

<213>  Mus musculus



<400>  39

tcagaaggta tcggggttag gatgaaagtt tcactgtgtc tcagcatagt gtggaggaga       60



gaagtagttt ctgaatagta gcttcatatc catccaagat gcacttgcag aggtagatgt      120



tggcgagctc tgcctttggt cccaggatgg ggaagtgggc tccgctgatc ttaagagagt      180



tttagccact acagatgaat tttgactgat ctttgccttc ccttctttca ccctctccct      240



tgccaaaaaa catgggaaag atgcataatt ggaagaatag aaggtactgg gaaaacaaaa      300



tagatcaggt tattattgaa acaaagtatt ttctgttgga tacctgaggc agagccagaa      360



aaaaaagttt tatttatttt attttttcta ggaaggcttt aaaaaatatt taacttacaa      420



agtttttgca cctcatttta cagtggtaaa agtttgatta attttaatat gaagttcctt      480



ttgccctata gcagatcaaa gttcagatga aaatgttcag agttaacaga ctctctggtt      540



gctaatgttg ttgaggtaga ggatctacaa agaaacagga cccccccccc attcattttt      600



aaaatgtttg gatttgttca tagtaaagat gatctttccc atctgtcggt acagttctgc      660



tcctctgtgt gtgtagtacc tgcagatctt accgcaccaa catctgttct tatacacagg      720



gcttttgttg ttgtaacact ctgactttaa aagtaagttg tttgctgatt tctgcactaa      780



ttatgcaatt tcattttttt tccccttcat ttcagccaaa tgtgtgtgtt cagtctgtgc      840



tttctaagta gttgggtatc agacgtgtta caaagaatgg ctggacatgt cttcttgact      900



cttccagaat ttgtgtggga ctttgcctga tattatgagt tctttccctt tgaagttaaa      960



gctctctttt aggttttgta ggatgtcatt tgatgagttg ttggttaaat ttctggaaga     1020



ggtctgagtt cttgttctaa gtcataagct aaaggaagct ttaaacttga ccaggagtta     1080



tgagtggggt gagcaaagcc ttggtgattg catttaggtt gaatgtgtgg cttgggagtc     1140



cttggggtgt gagcctgatt taaaattcag acatgtaact ctccaccact aaggcggata     1200



ttttttaaag tggcgactag agtctaaatt cctgactagg ctctaacgag aaactcctct     1260



ttccccaggt tatgaagaca gtatggagtt tccagaccac agcagacatt tgctgcagtg     1320



tctgagcgag cagaggcacc agggctttct ttgtgactgc actgttctgg tgggagatgc     1380



ccagttccgg gcacaccgag ctgttctggc ttcatgcagc atgtatttcc acctctttta     1440



caaggaccag ctggacaaaa gagacattgt tcatctgaac agcgacattg tgacagcccc     1500



cgctttcgct ctcctgcttg aattcatgta cgaagggaaa ctccagttca aagacttgcc     1560



cattgaggac gtgctagcag ctgccagtta tctccacatg tatgacattg tcaaagtctg     1620



caaaaagaag ctgaaagaga aagctaccac agaggcggac agcaccaaaa aagaagaaga     1680



tgcttcaagt tgttcggata aagtcgagag cctctcagac ggcagcagcc acatggcagg     1740



tgacctgccc agtgatgaag atgaaggcga agatgacaaa ttgaacattc tacccagcaa     1800



aagggacttg gcagctgagc ctgggaacat gtggatgcga ttgccctcag actcagcagg     1860



catcccccag gctggcggag aggccgagcc acacgccaca gcagctggaa aaacagtagc     1920



cagcccctgc agctcaacag agtctttgtc ccagaggtct gtcacctccg tgagggattc     1980



ggcagatgtt gactgtgtgc tggacctgtc tgtcaagtcc agcctttcag gagttgaaaa     2040



tctgaacagc tcttatttct cttcacagga cgtgctgaga agcaacctgg tgcaggtgaa     2100



ggtggagaaa gaggcgtcct gtgatgagag tgatgttggc actaatgact atgacatgga     2160



acatagcact gtgaaagaga gtgtgagcac taacaacagg gtacagtatg agccagccca     2220



cctggctcct ctgagggagg actcggtctt aagggaactg gatcgggagg acaaagccag     2280



cgatgatgag atgatgaccc cagagagcga gcgggtccag gtggaagggg gcatggagaa     2340



cagtctgctt ccctacgtct ccaatatcct gagccccgca ggccagatct tcatgtgccc     2400



cctgtgcaac aaagtcttcc ccagccccca catcctgcag atccacctga gcacgcactt     2460



ccgagagcag gatggcatcc gtagcaagcc tgccgccgat gtcaatgtgc ccacgtgctc     2520



cctgtgtggg aagactttct cctgcatgta caccctcaag cgccacgaga ggactcactc     2580



gggggagaag ccctacacgt gcacccaatg cggcaagagt ttccagtact cgcacaacct     2640



gagccgtcat gccgtggtgc acacccgcga gaagccccat gcctgcaagt ggtgcgagcg     2700



caggttcacg cagtccggag acctgtacag acacatccgc aagttccact gtgagttggt     2760



gaactccttg tcggtcaaaa gtgaagcgct gagcttgccc actgtcagag actggacctt     2820



agaagatagc tctcaagaac tttggaaata attttatata tatatatata taaataatat     2880



atatatatat atatacatat atatacatag atctctatat agttgtggta cggtctaaaa     2940



gcagtcttgt ttcctggaac tgaaaagttg ggatcttaac ttgtttttgc actttagaat     3000



aatagcatga gaatctcact aatttagcat tctgataaaa gaaactagag caagtcacaa     3060



gtagagagct gtctttcttt tgagggttag gccaagttag ccaataaaac cttctcaaca     3120



aatggttctg tcacaaacgc tttcacatgg cttacttttg tacacactgc attgtcttga     3180



gcgctttccc tgtgctccac actgttttgt tttgttttgt tttcagagta gaaatcccct     3240



ccagtttatt agcctcttta tatgtctcaa attgcatgaa tattttctgg ctgttggaaa     3300



cctgaatgct tttagaccca aatggaaaat ttctgaaatg ctggattatc tatttttaaa     3360



caagcagttg acttaaaact ttgtgtggca acttctggtt ttctgatggt ccccagtgag     3420



agaaatctga cagtacactg ggtcactggg actgtctctg tgaaggtttg cttgagatga     3480



aaaaggatat tgcagcttca gcagtgttga actgtgtgtt taaaatgtga attactgttc     3540



ttgtatactg taattgatta cacgggctgg ggggggtgtc aaagaacttg acaggttgtg     3600



ttgatgctct tagttgagtc ttgaaaagta aatattaacg ctacagaaat gcatgagttt     3660



caatatattt tttgtctttg tttgcattgt ataactttaa cgagtgagtt taaaattatt     3720



taatttcctt agaaaaatag caccatttgg gaaaaaaact ggtgttacga agaacataaa     3780



tgcactgtct ttatttttat ttttatttta tataatttaa attgactttt cccacgtctt     3840



taagtttgaa actgttaagc tgaataaaaa cttaagctgc aaattgataa cttcgctaca     3900



ttacaaggaa catataaatg tttacaaacg gcttaaagaa ttgcatgtgc agtgtgcatt     3960



cataccacac ttgtaattgc acagaaccca tgccagctca gagtttaggt gtacacacgt     4020



acccagccga gtgtttttag aataactact gcacaaattg acaataggtc ataggtcatt     4080



ctctctctcc ctcctttttg cttccccttt ctttttctcc cctatttcct ttccttcccc     4140



ctacccccta actcatgaaa agattctatg gactgaaaaa gccccaggct gaaaggactg     4200



aaccgccttg attgacatgg ggaggggggt tagtagactg tgtatcggca gcagaggctg     4260



cagcccgatg tgtggttctg atggccagcg cggggcagaa gcgttttgca cactgtttgt     4320



tttcctgtct tgcacttaca aataaggtct atgggagtag catgggaaac agtggttgtt     4380



tttccctttt tcttttttaa ttgcttttgt ttaaaatttg atcgccttaa ctactgtaaa     4440



catagcctat ttttgtgctt aagatactga atggaaaact ccattgtgtg ttgctggact     4500



gttttggaaa tatttggtca aatgtatgtt aatttggctg taatggcatt taaagcaaac     4560



aaacaaacaa acaaacaaag ctgtgaaaat ggccttggag cattatcttt agttacttga     4620



agagtttcta gttttttttt ttttaataca gtttatgtta aaataatctt tattaatcta     4680



gaggagacaa tcaatgtctg tggaagaacg gacttttttg gattttcttt tttaatggtc     4740



attgtgagtg attgctcttt cttttactta gtttcacatt cttcctttgt tctaaatctt     4800



agactgacat ctagctttga caatcatagt atgttttatt tcctgagggg gaataactta     4860



taatgctgtt tagttttgta ctattggtgt gttggtgaat ttttaaactg tgtgctaact     4920



gcaataaatt atatgaactg agaaaaaaaa aaaa                                 4954





<210>  40

<211>  530

<212>  PRT

<213>  Mus musculus



<400>  40



Cys Pro Lys Gly Tyr Glu Asp Ser Met Glu Phe Pro Asp His Ser Arg 

1               5                   10                  15      





His Leu Leu Gln Cys Leu Ser Glu Gln Arg His Gln Gly Phe Leu Cys 

            20                  25                  30          





Asp Cys Thr Val Leu Val Gly Asp Ala Gln Phe Arg Ala His Arg Ala 

        35                  40                  45              





Val Leu Ala Ser Cys Ser Met Tyr Phe His Leu Phe Tyr Lys Asp Gln 

    50                  55                  60                  





Leu Asp Lys Arg Asp Ile Val His Leu Asn Ser Asp Ile Val Thr Ala 

65                  70                  75                  80  





Pro Ala Phe Ala Leu Leu Leu Glu Phe Met Tyr Glu Gly Lys Leu Gln 

                85                  90                  95      





Phe Lys Asp Leu Pro Ile Glu Asp Val Leu Ala Ala Ala Ser Tyr Leu 

            100                 105                 110         





His Met Tyr Asp Ile Val Lys Val Cys Lys Lys Lys Leu Lys Glu Lys 

        115                 120                 125             





Ala Thr Thr Glu Ala Asp Ser Thr Lys Lys Glu Glu Asp Ala Ser Ser 

    130                 135                 140                 





Cys Ser Asp Lys Val Glu Ser Leu Ser Asp Gly Ser Ser His Met Ala 

145                 150                 155                 160 





Gly Asp Leu Pro Ser Asp Glu Asp Glu Gly Glu Asp Asp Lys Leu Asn 

                165                 170                 175     





Ile Leu Pro Ser Lys Arg Asp Leu Ala Ala Glu Pro Gly Asn Met Trp 

            180                 185                 190         





Met Arg Leu Pro Ser Asp Ser Ala Gly Ile Pro Gln Ala Gly Gly Glu 

        195                 200                 205             





Ala Glu Pro His Ala Thr Ala Ala Gly Lys Thr Val Ala Ser Pro Cys 

    210                 215                 220                 





Ser Ser Thr Glu Ser Leu Ser Gln Arg Ser Val Thr Ser Val Arg Asp 

225                 230                 235                 240 





Ser Ala Asp Val Asp Cys Val Leu Asp Leu Ser Val Lys Ser Ser Leu 

                245                 250                 255     





Ser Gly Val Glu Asn Leu Asn Ser Ser Tyr Phe Ser Ser Gln Asp Val 

            260                 265                 270         





Leu Arg Ser Asn Leu Val Gln Val Lys Val Glu Lys Glu Ala Ser Cys 

        275                 280                 285             





Asp Glu Ser Asp Val Gly Thr Asn Asp Tyr Asp Met Glu His Ser Thr 

    290                 295                 300                 





Val Lys Glu Ser Val Ser Thr Asn Asn Arg Val Gln Tyr Glu Pro Ala 

305                 310                 315                 320 





His Leu Ala Pro Leu Arg Glu Asp Ser Val Leu Arg Glu Leu Asp Arg 

                325                 330                 335     





Glu Asp Lys Ala Ser Asp Asp Glu Met Met Thr Pro Glu Ser Glu Arg 

            340                 345                 350         





Val Gln Val Glu Gly Gly Met Glu Asn Ser Leu Leu Pro Tyr Val Ser 

        355                 360                 365             





Asn Ile Leu Ser Pro Ala Gly Gln Ile Phe Met Cys Pro Leu Cys Asn 

    370                 375                 380                 





Lys Val Phe Pro Ser Pro His Ile Leu Gln Ile His Leu Ser Thr His 

385                 390                 395                 400 





Phe Arg Glu Gln Asp Gly Ile Arg Ser Lys Pro Ala Ala Asp Val Asn 

                405                 410                 415     





Val Pro Thr Cys Ser Leu Cys Gly Lys Thr Phe Ser Cys Met Tyr Thr 

            420                 425                 430         





Leu Lys Arg His Glu Arg Thr His Ser Gly Glu Lys Pro Tyr Thr Cys 

        435                 440                 445             





Thr Gln Cys Gly Lys Ser Phe Gln Tyr Ser His Asn Leu Ser Arg His 

    450                 455                 460                 





Ala Val Val His Thr Arg Glu Lys Pro His Ala Cys Lys Trp Cys Glu 

465                 470                 475                 480 





Arg Arg Phe Thr Gln Ser Gly Asp Leu Tyr Arg His Ile Arg Lys Phe 

                485                 490                 495     





His Cys Glu Leu Val Asn Ser Leu Ser Val Lys Ser Glu Ala Leu Ser 

            500                 505                 510         





Leu Pro Thr Val Arg Asp Trp Thr Leu Glu Asp Ser Ser Gln Glu Leu 

        515                 520                 525             





Trp Lys 

    530 





<210>  41

<211>  4123

<212>  DNA

<213>  Mus musculus



<400>  41

aggctgcggc cgccgctggg ctgctgccat ggggagccgt tgaaagagtg gggccctgtg       60



gctcggccgc gcgcctcagg ctgccagcgc gggcgggggg cggcgggggc gcgcggggcc      120



cgggccgggg ccggcgggcg ggcgggggcc ggcggaggac gcccacaagt ccagcggcgg      180



cggcggcggc agaggaggag gaggaggagg acgcggcggg gacgcggcga ctcgggccgc      240



tccgtaacct ccgagggtcc gcggtagcgg tggacgggtc gatccgtgga gtggatgtct      300



tcgggccatt gcggtgcttg ggactcatta aactgtcact cacccccacc accaccccac      360



tggtctgctt tttttccacc gatgtaacag acctgcagcc agcaagactc cgagggaagg      420



acttaatcaa gtttatgtgt cctaaaggtt atgaagacag tatggagttt ccagaccaca      480



gcagacattt gctgcagtgt ctgagcgagc agaggcacca gggctttctt tgtgactgca      540



ctgttctggt gggagatgcc cagttccggg cacaccgagc tgttctggct tcatgcagca      600



tgtatttcca cctcttttac aaggaccagc tggacaaaag agacattgtt catctgaaca      660



gcgacattgt gacagccccc gctttcgctc tcctgcttga attcatgtac gaagggaaac      720



tccagttcaa agacttgccc attgaggacg tgctagcagc tgccagttat ctccacatgt      780



atgacattgt caaagtctgc aaaaagaagc tgaaagagaa agctaccaca gaggcggaca      840



gcaccaaaaa agaagaagat gcttcaagtt gttcggataa agtcgagagc ctctcagacg      900



gcagcagcca catggcaggt gacctgccca gtgatgaaga tgaaggcgaa gatgacaaat      960



tgaacattct acccagcaaa agggacttgg cagctgagcc tgggaacatg tggatgcgat     1020



tgccctcaga ctcagcaggc atcccccagg ctggcggaga ggccgagcca cacgccacag     1080



cagctggaaa aacagtagcc agcccctgca gctcaacaga gtctttgtcc cagaggtctg     1140



tcacctccgt gagggattcg gcagatgttg actgtgtgct ggacctgtct gtcaagtcca     1200



gcctttcagg agttgaaaat ctgaacagct cttatttctc ttcacaggac gtgctgagaa     1260



gcaacctggt gcaggtgaag gtggagaaag aggcgtcctg tgatgagagt gatgttggca     1320



ctaatgacta tgacatggaa catagcactg tgaaagagag tgtgagcact aacaacaggg     1380



tacagtatga gccagcccac ctggctcctc tgagggagga ctcggtctta agggaactgg     1440



atcgggagga caaagccagc gatgatgaga tgatgacccc agagagcgag cgggtccagg     1500



tggaaggggg catggagaac agtctgcttc cctacgtctc caatatcctg agccccgcag     1560



gccagatctt catgtgcccc ctgtgcaaca aagtcttccc cagcccccac atcctgcaga     1620



tccacctgag cacgcacttc cgagagcagg atggcatccg tagcaagcct gccgccgatg     1680



tcaatgtgcc cacgtgctcc ctgtgtggga agactttctc ctgcatgtac accctcaagc     1740



gccacgagag gactcactcg ggggagaagc cctacacgtg cacccaatgc ggcaagagtt     1800



tccagtactc gcacaacctg agccgtcatg ccgtggtgca cacccgcgag aagccccatg     1860



cctgcaagtg gtgcgagcgc aggttcacgc agtccggaga cctgtacaga cacatccgca     1920



agttccactg tgagttggtg aactccttgt cggtcaaaag tgaagcgctg agcttgccca     1980



ctgtcagaga ctggacctta gaagatagct ctcaagaact ttggaaataa ttttatatat     2040



atatatatat aaataatata tatatatata tatacatata tatacataga tctctatata     2100



gttgtggtac ggtctaaaag cagtcttgtt tcctggaact gaaaagttgg gatcttaact     2160



tgtttttgca ctttagaata atagcatgag aatctcacta atttagcatt ctgataaaag     2220



aaactagagc aagtcacaag tagagagctg tctttctttt gagggttagg ccaagttagc     2280



caataaaacc ttctcaacaa atggttctgt cacaaacgct ttcacatggc ttacttttgt     2340



acacactgca ttgtcttgag cgctttccct gtgctccaca ctgttttgtt ttgttttgtt     2400



ttcagagtag aaatcccctc cagtttatta gcctctttat atgtctcaaa ttgcatgaat     2460



attttctggc tgttggaaac ctgaatgctt ttagacccaa atggaaaatt tctgaaatgc     2520



tggattatct atttttaaac aagcagttga cttaaaactt tgtgtggcaa cttctggttt     2580



tctgatggtc cccagtgaga gaaatctgac agtacactgg gtcactggga ctgtctctgt     2640



gaaggtttgc ttgagatgaa aaaggatatt gcagcttcag cagtgttgaa ctgtgtgttt     2700



aaaatgtgaa ttactgttct tgtatactgt aattgattac acgggctggg gggggtgtca     2760



aagaacttga caggttgtgt tgatgctctt agttgagtct tgaaaagtaa atattaacgc     2820



tacagaaatg catgagtttc aatatatttt ttgtctttgt ttgcattgta taactttaac     2880



gagtgagttt aaaattattt aatttcctta gaaaaatagc accatttggg aaaaaaactg     2940



gtgttacgaa gaacataaat gcactgtctt tatttttatt tttattttat ataatttaaa     3000



ttgacttttc ccacgtcttt aagtttgaaa ctgttaagct gaataaaaac ttaagctgca     3060



aattgataac ttcgctacat tacaaggaac atataaatgt ttacaaacgg cttaaagaat     3120



tgcatgtgca gtgtgcattc ataccacact tgtaattgca cagaacccat gccagctcag     3180



agtttaggtg tacacacgta cccagccgag tgtttttaga ataactactg cacaaattga     3240



caataggtca taggtcattc tctctctccc tcctttttgc ttcccctttc tttttctccc     3300



ctatttcctt tccttccccc taccccctaa ctcatgaaaa gattctatgg actgaaaaag     3360



ccccaggctg aaaggactga accgccttga ttgacatggg gaggggggtt agtagactgt     3420



gtatcggcag cagaggctgc agcccgatgt gtggttctga tggccagcgc ggggcagaag     3480



cgttttgcac actgtttgtt ttcctgtctt gcacttacaa ataaggtcta tgggagtagc     3540



atgggaaaca gtggttgttt ttcccttttt cttttttaat tgcttttgtt taaaatttga     3600



tcgccttaac tactgtaaac atagcctatt tttgtgctta agatactgaa tggaaaactc     3660



cattgtgtgt tgctggactg ttttggaaat atttggtcaa atgtatgtta atttggctgt     3720



aatggcattt aaagcaaaca aacaaacaaa caaacaaagc tgtgaaaatg gccttggagc     3780



attatcttta gttacttgaa gagtttctag tttttttttt tttaatacag tttatgttaa     3840



aataatcttt attaatctag aggagacaat caatgtctgt ggaagaacgg acttttttgg     3900



attttctttt ttaatggtca ttgtgagtga ttgctctttc ttttacttag tttcacattc     3960



ttcctttgtt ctaaatctta gactgacatc tagctttgac aatcatagta tgttttattt     4020



cctgaggggg aataacttat aatgctgttt agttttgtac tattggtgtg ttggtgaatt     4080



tttaaactgt gtgctaactg caataaatta tatgaactga gaa                       4123





<210>  42

<211>  521

<212>  PRT

<213>  Mus musculus



<400>  42



Glu Phe Pro Asp His Ser Arg His Leu Leu Gln Cys Leu Ser Glu Gln 

1               5                   10                  15      





Arg His Gln Gly Phe Leu Cys Asp Cys Thr Val Leu Val Gly Asp Ala 

            20                  25                  30          





Gln Phe Arg Ala His Arg Ala Val Leu Ala Ser Cys Ser Met Tyr Phe 

        35                  40                  45              





His Leu Phe Tyr Lys Asp Gln Leu Asp Lys Arg Asp Ile Val His Leu 

    50                  55                  60                  





Asn Ser Asp Ile Val Thr Ala Pro Ala Phe Ala Leu Leu Leu Glu Phe 

65                  70                  75                  80  





Met Tyr Glu Gly Lys Leu Gln Phe Lys Asp Leu Pro Ile Glu Asp Val 

                85                  90                  95      





Leu Ala Ala Ala Ser Tyr Leu His Met Tyr Asp Ile Val Lys Val Cys 

            100                 105                 110         





Lys Lys Lys Leu Lys Glu Lys Ala Thr Thr Glu Ala Asp Ser Thr Lys 

        115                 120                 125             





Lys Glu Glu Asp Ala Ser Ser Cys Ser Asp Lys Val Glu Ser Leu Ser 

    130                 135                 140                 





Asp Gly Ser Ser His Met Ala Gly Asp Leu Pro Ser Asp Glu Asp Glu 

145                 150                 155                 160 





Gly Glu Asp Asp Lys Leu Asn Ile Leu Pro Ser Lys Arg Asp Leu Ala 

                165                 170                 175     





Ala Glu Pro Gly Asn Met Trp Met Arg Leu Pro Ser Asp Ser Ala Gly 

            180                 185                 190         





Ile Pro Gln Ala Gly Gly Glu Ala Glu Pro His Ala Thr Ala Ala Gly 

        195                 200                 205             





Lys Thr Val Ala Ser Pro Cys Ser Ser Thr Glu Ser Leu Ser Gln Arg 

    210                 215                 220                 





Ser Val Thr Ser Val Arg Asp Ser Ala Asp Val Asp Cys Val Leu Asp 

225                 230                 235                 240 





Leu Ser Val Lys Ser Ser Leu Ser Gly Val Glu Asn Leu Asn Ser Ser 

                245                 250                 255     





Tyr Phe Ser Ser Gln Asp Val Leu Arg Ser Asn Leu Val Gln Val Lys 

            260                 265                 270         





Val Glu Lys Glu Ala Ser Cys Asp Glu Ser Asp Val Gly Thr Asn Asp 

        275                 280                 285             





Tyr Asp Met Glu His Ser Thr Val Lys Glu Ser Val Ser Thr Asn Asn 

    290                 295                 300                 





Arg Val Gln Tyr Glu Pro Ala His Leu Ala Pro Leu Arg Glu Asp Ser 

305                 310                 315                 320 





Val Leu Arg Glu Leu Asp Arg Glu Asp Lys Ala Ser Asp Asp Glu Met 

                325                 330                 335     





Met Thr Pro Glu Ser Glu Arg Val Gln Val Glu Gly Gly Met Glu Asn 

            340                 345                 350         





Ser Leu Leu Pro Tyr Val Ser Asn Ile Leu Ser Pro Ala Gly Gln Ile 

        355                 360                 365             





Phe Met Cys Pro Leu Cys Asn Lys Val Phe Pro Ser Pro His Ile Leu 

    370                 375                 380                 





Gln Ile His Leu Ser Thr His Phe Arg Glu Gln Asp Gly Ile Arg Ser 

385                 390                 395                 400 





Lys Pro Ala Ala Asp Val Asn Val Pro Thr Cys Ser Leu Cys Gly Lys 

                405                 410                 415     





Thr Phe Ser Cys Met Tyr Thr Leu Lys Arg His Glu Arg Thr His Ser 

            420                 425                 430         





Gly Glu Lys Pro Tyr Thr Cys Thr Gln Cys Gly Lys Ser Phe Gln Tyr 

        435                 440                 445             





Ser His Asn Leu Ser Arg His Ala Val Val His Thr Arg Glu Lys Pro 

    450                 455                 460                 





His Ala Cys Lys Trp Cys Glu Arg Arg Phe Thr Gln Ser Gly Asp Leu 

465                 470                 475                 480 





Tyr Arg His Ile Arg Lys Phe His Cys Glu Leu Val Asn Ser Leu Ser 

                485                 490                 495     





Val Lys Ser Glu Ala Leu Ser Leu Pro Thr Val Arg Asp Trp Thr Leu 

            500                 505                 510         





Glu Asp Ser Ser Gln Glu Leu Trp Lys 

        515                 520     





<210>  43

<211>  3937

<212>  DNA

<213>  Mus musculus



<400>  43

aggctgcggc cgccgctggg ctgctgccat ggggagccgt tgaaagagtg gggccctgtg       60



gctcggccgc gcgcctcagg ctgccagcgc gggcgggggg cggcgggggc gcgcggggcc      120



cgggccgggg ccggcgggcg ggcgggggcc ggcggaggac gcccacaagt ccagcggcgg      180



cggcggcggc agaggaggag gaggaggagg acgcggcggg gacgcggcga ctcgggccgc      240



tccgtgttat gaagacagta tggagtttcc agaccacagc agacatttgc tgcagtgtct      300



gagcgagcag aggcaccagg gctttctttg tgactgcact gttctggtgg gagatgccca      360



gttccgggca caccgagctg ttctggcttc atgcagcatg tatttccacc tcttttacaa      420



ggaccagctg gacaaaagag acattgttca tctgaacagc gacattgtga cagcccccgc      480



tttcgctctc ctgcttgaat tcatgtacga agggaaactc cagttcaaag acttgcccat      540



tgaggacgtg ctagcagctg ccagttatct ccacatgtat gacattgtca aagtctgcaa      600



aaagaagctg aaagagaaag ctaccacaga ggcggacagc accaaaaaag aagaagatgc      660



ttcaagttgt tcggataaag tcgagagcct ctcagacggc agcagccaca tggcaggtga      720



cctgcccagt gatgaagatg aaggcgaaga tgacaaattg aacattctac ccagcaaaag      780



ggacttggca gctgagcctg ggaacatgtg gatgcgattg ccctcagact cagcaggcat      840



cccccaggct ggcggagagg ccgagccaca cgccacagca gctggaaaaa cagtagccag      900



cccctgcagc tcaacagagt ctttgtccca gaggtctgtc acctccgtga gggattcggc      960



agatgttgac tgtgtgctgg acctgtctgt caagtccagc ctttcaggag ttgaaaatct     1020



gaacagctct tatttctctt cacaggacgt gctgagaagc aacctggtgc aggtgaaggt     1080



ggagaaagag gcgtcctgtg atgagagtga tgttggcact aatgactatg acatggaaca     1140



tagcactgtg aaagagagtg tgagcactaa caacagggta cagtatgagc cagcccacct     1200



ggctcctctg agggaggact cggtcttaag ggaactggat cgggaggaca aagccagcga     1260



tgatgagatg atgaccccag agagcgagcg ggtccaggtg gaagggggca tggagaacag     1320



tctgcttccc tacgtctcca atatcctgag ccccgcaggc cagatcttca tgtgccccct     1380



gtgcaacaaa gtcttcccca gcccccacat cctgcagatc cacctgagca cgcacttccg     1440



agagcaggat ggcatccgta gcaagcctgc cgccgatgtc aatgtgccca cgtgctccct     1500



gtgtgggaag actttctcct gcatgtacac cctcaagcgc cacgagagga ctcactcggg     1560



ggagaagccc tacacgtgca cccaatgcgg caagagtttc cagtactcgc acaacctgag     1620



ccgtcatgcc gtggtgcaca cccgcgagaa gccccatgcc tgcaagtggt gcgagcgcag     1680



gttcacgcag tccggagacc tgtacagaca catccgcaag ttccactgtg agttggtgaa     1740



ctccttgtcg gtcaaaagtg aagcgctgag cttgcccact gtcagagact ggaccttaga     1800



agatagctct caagaacttt ggaaataatt ttatatatat atatatataa ataatatata     1860



tatatatata tacatatata tacatagatc tctatatagt tgtggtacgg tctaaaagca     1920



gtcttgtttc ctggaactga aaagttggga tcttaacttg tttttgcact ttagaataat     1980



agcatgagaa tctcactaat ttagcattct gataaaagaa actagagcaa gtcacaagta     2040



gagagctgtc tttcttttga gggttaggcc aagttagcca ataaaacctt ctcaacaaat     2100



ggttctgtca caaacgcttt cacatggctt acttttgtac acactgcatt gtcttgagcg     2160



ctttccctgt gctccacact gttttgtttt gttttgtttt cagagtagaa atcccctcca     2220



gtttattagc ctctttatat gtctcaaatt gcatgaatat tttctggctg ttggaaacct     2280



gaatgctttt agacccaaat ggaaaatttc tgaaatgctg gattatctat ttttaaacaa     2340



gcagttgact taaaactttg tgtggcaact tctggttttc tgatggtccc cagtgagaga     2400



aatctgacag tacactgggt cactgggact gtctctgtga aggtttgctt gagatgaaaa     2460



aggatattgc agcttcagca gtgttgaact gtgtgtttaa aatgtgaatt actgttcttg     2520



tatactgtaa ttgattacac gggctggggg gggtgtcaaa gaacttgaca ggttgtgttg     2580



atgctcttag ttgagtcttg aaaagtaaat attaacgcta cagaaatgca tgagtttcaa     2640



tatatttttt gtctttgttt gcattgtata actttaacga gtgagtttaa aattatttaa     2700



tttccttaga aaaatagcac catttgggaa aaaaactggt gttacgaaga acataaatgc     2760



actgtcttta tttttatttt tattttatat aatttaaatt gacttttccc acgtctttaa     2820



gtttgaaact gttaagctga ataaaaactt aagctgcaaa ttgataactt cgctacatta     2880



caaggaacat ataaatgttt acaaacggct taaagaattg catgtgcagt gtgcattcat     2940



accacacttg taattgcaca gaacccatgc cagctcagag tttaggtgta cacacgtacc     3000



cagccgagtg tttttagaat aactactgca caaattgaca ataggtcata ggtcattctc     3060



tctctccctc ctttttgctt cccctttctt tttctcccct atttcctttc cttcccccta     3120



ccccctaact catgaaaaga ttctatggac tgaaaaagcc ccaggctgaa aggactgaac     3180



cgccttgatt gacatgggga ggggggttag tagactgtgt atcggcagca gaggctgcag     3240



cccgatgtgt ggttctgatg gccagcgcgg ggcagaagcg ttttgcacac tgtttgtttt     3300



cctgtcttgc acttacaaat aaggtctatg ggagtagcat gggaaacagt ggttgttttt     3360



ccctttttct tttttaattg cttttgttta aaatttgatc gccttaacta ctgtaaacat     3420



agcctatttt tgtgcttaag atactgaatg gaaaactcca ttgtgtgttg ctggactgtt     3480



ttggaaatat ttggtcaaat gtatgttaat ttggctgtaa tggcatttaa agcaaacaaa     3540



caaacaaaca aacaaagctg tgaaaatggc cttggagcat tatctttagt tacttgaaga     3600



gtttctagtt tttttttttt taatacagtt tatgttaaaa taatctttat taatctagag     3660



gagacaatca atgtctgtgg aagaacggac ttttttggat tttctttttt aatggtcatt     3720



gtgagtgatt gctctttctt ttacttagtt tcacattctt cctttgttct aaatcttaga     3780



ctgacatcta gctttgacaa tcatagtatg ttttatttcc tgagggggaa taacttataa     3840



tgctgtttag ttttgtacta ttggtgtgtt ggtgaatttt taaactgtgt gctaactgca     3900



ataaattata tgaactgaga aaaaaaaaaa aaaaaaa                              3937





<210>  44

<211>  521

<212>  PRT

<213>  Mus musculus



<400>  44



Glu Phe Pro Asp His Ser Arg His Leu Leu Gln Cys Leu Ser Glu Gln 

1               5                   10                  15      





Arg His Gln Gly Phe Leu Cys Asp Cys Thr Val Leu Val Gly Asp Ala 

            20                  25                  30          





Gln Phe Arg Ala His Arg Ala Val Leu Ala Ser Cys Ser Met Tyr Phe 

        35                  40                  45              





His Leu Phe Tyr Lys Asp Gln Leu Asp Lys Arg Asp Ile Val His Leu 

    50                  55                  60                  





Asn Ser Asp Ile Val Thr Ala Pro Ala Phe Ala Leu Leu Leu Glu Phe 

65                  70                  75                  80  





Met Tyr Glu Gly Lys Leu Gln Phe Lys Asp Leu Pro Ile Glu Asp Val 

                85                  90                  95      





Leu Ala Ala Ala Ser Tyr Leu His Met Tyr Asp Ile Val Lys Val Cys 

            100                 105                 110         





Lys Lys Lys Leu Lys Glu Lys Ala Thr Thr Glu Ala Asp Ser Thr Lys 

        115                 120                 125             





Lys Glu Glu Asp Ala Ser Ser Cys Ser Asp Lys Val Glu Ser Leu Ser 

    130                 135                 140                 





Asp Gly Ser Ser His Met Ala Gly Asp Leu Pro Ser Asp Glu Asp Glu 

145                 150                 155                 160 





Gly Glu Asp Asp Lys Leu Asn Ile Leu Pro Ser Lys Arg Asp Leu Ala 

                165                 170                 175     





Ala Glu Pro Gly Asn Met Trp Met Arg Leu Pro Ser Asp Ser Ala Gly 

            180                 185                 190         





Ile Pro Gln Ala Gly Gly Glu Ala Glu Pro His Ala Thr Ala Ala Gly 

        195                 200                 205             





Lys Thr Val Ala Ser Pro Cys Ser Ser Thr Glu Ser Leu Ser Gln Arg 

    210                 215                 220                 





Ser Val Thr Ser Val Arg Asp Ser Ala Asp Val Asp Cys Val Leu Asp 

225                 230                 235                 240 





Leu Ser Val Lys Ser Ser Leu Ser Gly Val Glu Asn Leu Asn Ser Ser 

                245                 250                 255     





Tyr Phe Ser Ser Gln Asp Val Leu Arg Ser Asn Leu Val Gln Val Lys 

            260                 265                 270         





Val Glu Lys Glu Ala Ser Cys Asp Glu Ser Asp Val Gly Thr Asn Asp 

        275                 280                 285             





Tyr Asp Met Glu His Ser Thr Val Lys Glu Ser Val Ser Thr Asn Asn 

    290                 295                 300                 





Arg Val Gln Tyr Glu Pro Ala His Leu Ala Pro Leu Arg Glu Asp Ser 

305                 310                 315                 320 





Val Leu Arg Glu Leu Asp Arg Glu Asp Lys Ala Ser Asp Asp Glu Met 

                325                 330                 335     





Met Thr Pro Glu Ser Glu Arg Val Gln Val Glu Gly Gly Met Glu Asn 

            340                 345                 350         





Ser Leu Leu Pro Tyr Val Ser Asn Ile Leu Ser Pro Ala Gly Gln Ile 

        355                 360                 365             





Phe Met Cys Pro Leu Cys Asn Lys Val Phe Pro Ser Pro His Ile Leu 

    370                 375                 380                 





Gln Ile His Leu Ser Thr His Phe Arg Glu Gln Asp Gly Ile Arg Ser 

385                 390                 395                 400 





Lys Pro Ala Ala Asp Val Asn Val Pro Thr Cys Ser Leu Cys Gly Lys 

                405                 410                 415     





Thr Phe Ser Cys Met Tyr Thr Leu Lys Arg His Glu Arg Thr His Ser 

            420                 425                 430         





Gly Glu Lys Pro Tyr Thr Cys Thr Gln Cys Gly Lys Ser Phe Gln Tyr 

        435                 440                 445             





Ser His Asn Leu Ser Arg His Ala Val Val His Thr Arg Glu Lys Pro 

    450                 455                 460                 





His Ala Cys Lys Trp Cys Glu Arg Arg Phe Thr Gln Ser Gly Asp Leu 

465                 470                 475                 480 





Tyr Arg His Ile Arg Lys Phe His Cys Glu Leu Val Asn Ser Leu Ser 

                485                 490                 495     





Val Lys Ser Glu Ala Leu Ser Leu Pro Thr Val Arg Asp Trp Thr Leu 

            500                 505                 510         





Glu Asp Ser Ser Gln Glu Leu Trp Lys 

        515                 520     





<210>  45

<211>  4039

<212>  DNA

<213>  Mus musculus



<400>  45

aggctgcggc cgccgctggg ctgctgccat ggggagccgt tgaaagagtg gggccctgtg       60



gctcggccgc gcgcctcagg ctgccagcgc gggcgggggg cggcgggggc gcgcggggcc      120



cgggccgggg ccggcgggcg ggcgggggcc ggcggaggac gcccacaagt ccagcggcgg      180



cggcggcggc agaggaggag gaggaggagg acgcggcggg gacgcggcga ctcgggccgc      240



tccgtaacct ccgagggtcc gcggtagcgg tggacgggtc gatccgtgga gtggatgtct      300



tcgggccatt gcggtgcttg ggactcatta aactgtcact cacccccacc accaccccac      360



tgggttatga agacagtatg gagtttccag accacagcag acatttgctg cagtgtctga      420



gcgagcagag gcaccagggc tttctttgtg actgcactgt tctggtggga gatgcccagt      480



tccgggcaca ccgagctgtt ctggcttcat gcagcatgta tttccacctc ttttacaagg      540



accagctgga caaaagagac attgttcatc tgaacagcga cattgtgaca gcccccgctt      600



tcgctctcct gcttgaattc atgtacgaag ggaaactcca gttcaaagac ttgcccattg      660



aggacgtgct agcagctgcc agttatctcc acatgtatga cattgtcaaa gtctgcaaaa      720



agaagctgaa agagaaagct accacagagg cggacagcac caaaaaagaa gaagatgctt      780



caagttgttc ggataaagtc gagagcctct cagacggcag cagccacatg gcaggtgacc      840



tgcccagtga tgaagatgaa ggcgaagatg acaaattgaa cattctaccc agcaaaaggg      900



acttggcagc tgagcctggg aacatgtgga tgcgattgcc ctcagactca gcaggcatcc      960



cccaggctgg cggagaggcc gagccacacg ccacagcagc tggaaaaaca gtagccagcc     1020



cctgcagctc aacagagtct ttgtcccaga ggtctgtcac ctccgtgagg gattcggcag     1080



atgttgactg tgtgctggac ctgtctgtca agtccagcct ttcaggagtt gaaaatctga     1140



acagctctta tttctcttca caggacgtgc tgagaagcaa cctggtgcag gtgaaggtgg     1200



agaaagaggc gtcctgtgat gagagtgatg ttggcactaa tgactatgac atggaacata     1260



gcactgtgaa agagagtgtg agcactaaca acagggtaca gtatgagcca gcccacctgg     1320



ctcctctgag ggaggactcg gtcttaaggg aactggatcg ggaggacaaa gccagcgatg     1380



atgagatgat gaccccagag agcgagcggg tccaggtgga agggggcatg gagaacagtc     1440



tgcttcccta cgtctccaat atcctgagcc ccgcaggcca gatcttcatg tgccccctgt     1500



gcaacaaagt cttccccagc ccccacatcc tgcagatcca cctgagcacg cacttccgag     1560



agcaggatgg catccgtagc aagcctgccg ccgatgtcaa tgtgcccacg tgctccctgt     1620



gtgggaagac tttctcctgc atgtacaccc tcaagcgcca cgagaggact cactcggggg     1680



agaagcccta cacgtgcacc caatgcggca agagtttcca gtactcgcac aacctgagcc     1740



gtcatgccgt ggtgcacacc cgcgagaagc cccatgcctg caagtggtgc gagcgcaggt     1800



tcacgcagtc cggagacctg tacagacaca tccgcaagtt ccactgtgag ttggtgaact     1860



ccttgtcggt caaaagtgaa gcgctgagct tgcccactgt cagagactgg accttagaag     1920



atagctctca agaactttgg aaataatttt atatatatat atatataaat aatatatata     1980



tatatatata catatatata catagatctc tatatagttg tggtacggtc taaaagcagt     2040



cttgtttcct ggaactgaaa agttgggatc ttaacttgtt tttgcacttt agaataatag     2100



catgagaatc tcactaattt agcattctga taaaagaaac tagagcaagt cacaagtaga     2160



gagctgtctt tcttttgagg gttaggccaa gttagccaat aaaaccttct caacaaatgg     2220



ttctgtcaca aacgctttca catggcttac ttttgtacac actgcattgt cttgagcgct     2280



ttccctgtgc tccacactgt tttgttttgt tttgttttca gagtagaaat cccctccagt     2340



ttattagcct ctttatatgt ctcaaattgc atgaatattt tctggctgtt ggaaacctga     2400



atgcttttag acccaaatgg aaaatttctg aaatgctgga ttatctattt ttaaacaagc     2460



agttgactta aaactttgtg tggcaacttc tggttttctg atggtcccca gtgagagaaa     2520



tctgacagta cactgggtca ctgggactgt ctctgtgaag gtttgcttga gatgaaaaag     2580



gatattgcag cttcagcagt gttgaactgt gtgtttaaaa tgtgaattac tgttcttgta     2640



tactgtaatt gattacacgg gctggggggg gtgtcaaaga acttgacagg ttgtgttgat     2700



gctcttagtt gagtcttgaa aagtaaatat taacgctaca gaaatgcatg agtttcaata     2760



tattttttgt ctttgtttgc attgtataac tttaacgagt gagtttaaaa ttatttaatt     2820



tccttagaaa aatagcacca tttgggaaaa aaactggtgt tacgaagaac ataaatgcac     2880



tgtctttatt tttattttta ttttatataa tttaaattga cttttcccac gtctttaagt     2940



ttgaaactgt taagctgaat aaaaacttaa gctgcaaatt gataacttcg ctacattaca     3000



aggaacatat aaatgtttac aaacggctta aagaattgca tgtgcagtgt gcattcatac     3060



cacacttgta attgcacaga acccatgcca gctcagagtt taggtgtaca cacgtaccca     3120



gccgagtgtt tttagaataa ctactgcaca aattgacaat aggtcatagg tcattctctc     3180



tctccctcct ttttgcttcc cctttctttt tctcccctat ttcctttcct tccccctacc     3240



ccctaactca tgaaaagatt ctatggactg aaaaagcccc aggctgaaag gactgaaccg     3300



ccttgattga catggggagg ggggttagta gactgtgtat cggcagcaga ggctgcagcc     3360



cgatgtgtgg ttctgatggc cagcgcgggg cagaagcgtt ttgcacactg tttgttttcc     3420



tgtcttgcac ttacaaataa ggtctatggg agtagcatgg gaaacagtgg ttgtttttcc     3480



ctttttcttt tttaattgct tttgtttaaa atttgatcgc cttaactact gtaaacatag     3540



cctatttttg tgcttaagat actgaatgga aaactccatt gtgtgttgct ggactgtttt     3600



ggaaatattt ggtcaaatgt atgttaattt ggctgtaatg gcatttaaag caaacaaaca     3660



aacaaacaaa caaagctgtg aaaatggcct tggagcatta tctttagtta cttgaagagt     3720



ttctagtttt ttttttttta atacagttta tgttaaaata atctttatta atctagagga     3780



gacaatcaat gtctgtggaa gaacggactt ttttggattt tcttttttaa tggtcattgt     3840



gagtgattgc tctttctttt acttagtttc acattcttcc tttgttctaa atcttagact     3900



gacatctagc tttgacaatc atagtatgtt ttatttcctg agggggaata acttataatg     3960



ctgtttagtt ttgtactatt ggtgtgttgg tgaattttta aactgtgtgc taactgcaat     4020



aaattatatg aactgagaa                                                  4039





<210>  46

<211>  521

<212>  PRT

<213>  Mus musculus



<400>  46



Glu Phe Pro Asp His Ser Arg His Leu Leu Gln Cys Leu Ser Glu Gln 

1               5                   10                  15      





Arg His Gln Gly Phe Leu Cys Asp Cys Thr Val Leu Val Gly Asp Ala 

            20                  25                  30          





Gln Phe Arg Ala His Arg Ala Val Leu Ala Ser Cys Ser Met Tyr Phe 

        35                  40                  45              





His Leu Phe Tyr Lys Asp Gln Leu Asp Lys Arg Asp Ile Val His Leu 

    50                  55                  60                  





Asn Ser Asp Ile Val Thr Ala Pro Ala Phe Ala Leu Leu Leu Glu Phe 

65                  70                  75                  80  





Met Tyr Glu Gly Lys Leu Gln Phe Lys Asp Leu Pro Ile Glu Asp Val 

                85                  90                  95      





Leu Ala Ala Ala Ser Tyr Leu His Met Tyr Asp Ile Val Lys Val Cys 

            100                 105                 110         





Lys Lys Lys Leu Lys Glu Lys Ala Thr Thr Glu Ala Asp Ser Thr Lys 

        115                 120                 125             





Lys Glu Glu Asp Ala Ser Ser Cys Ser Asp Lys Val Glu Ser Leu Ser 

    130                 135                 140                 





Asp Gly Ser Ser His Met Ala Gly Asp Leu Pro Ser Asp Glu Asp Glu 

145                 150                 155                 160 





Gly Glu Asp Asp Lys Leu Asn Ile Leu Pro Ser Lys Arg Asp Leu Ala 

                165                 170                 175     





Ala Glu Pro Gly Asn Met Trp Met Arg Leu Pro Ser Asp Ser Ala Gly 

            180                 185                 190         





Ile Pro Gln Ala Gly Gly Glu Ala Glu Pro His Ala Thr Ala Ala Gly 

        195                 200                 205             





Lys Thr Val Ala Ser Pro Cys Ser Ser Thr Glu Ser Leu Ser Gln Arg 

    210                 215                 220                 





Ser Val Thr Ser Val Arg Asp Ser Ala Asp Val Asp Cys Val Leu Asp 

225                 230                 235                 240 





Leu Ser Val Lys Ser Ser Leu Ser Gly Val Glu Asn Leu Asn Ser Ser 

                245                 250                 255     





Tyr Phe Ser Ser Gln Asp Val Leu Arg Ser Asn Leu Val Gln Val Lys 

            260                 265                 270         





Val Glu Lys Glu Ala Ser Cys Asp Glu Ser Asp Val Gly Thr Asn Asp 

        275                 280                 285             





Tyr Asp Met Glu His Ser Thr Val Lys Glu Ser Val Ser Thr Asn Asn 

    290                 295                 300                 





Arg Val Gln Tyr Glu Pro Ala His Leu Ala Pro Leu Arg Glu Asp Ser 

305                 310                 315                 320 





Val Leu Arg Glu Leu Asp Arg Glu Asp Lys Ala Ser Asp Asp Glu Met 

                325                 330                 335     





Met Thr Pro Glu Ser Glu Arg Val Gln Val Glu Gly Gly Met Glu Asn 

            340                 345                 350         





Ser Leu Leu Pro Tyr Val Ser Asn Ile Leu Ser Pro Ala Gly Gln Ile 

        355                 360                 365             





Phe Met Cys Pro Leu Cys Asn Lys Val Phe Pro Ser Pro His Ile Leu 

    370                 375                 380                 





Gln Ile His Leu Ser Thr His Phe Arg Glu Gln Asp Gly Ile Arg Ser 

385                 390                 395                 400 





Lys Pro Ala Ala Asp Val Asn Val Pro Thr Cys Ser Leu Cys Gly Lys 

                405                 410                 415     





Thr Phe Ser Cys Met Tyr Thr Leu Lys Arg His Glu Arg Thr His Ser 

            420                 425                 430         





Gly Glu Lys Pro Tyr Thr Cys Thr Gln Cys Gly Lys Ser Phe Gln Tyr 

        435                 440                 445             





Ser His Asn Leu Ser Arg His Ala Val Val His Thr Arg Glu Lys Pro 

    450                 455                 460                 





His Ala Cys Lys Trp Cys Glu Arg Arg Phe Thr Gln Ser Gly Asp Leu 

465                 470                 475                 480 





Tyr Arg His Ile Arg Lys Phe His Cys Glu Leu Val Asn Ser Leu Ser 

                485                 490                 495     





Val Lys Ser Glu Ala Leu Ser Leu Pro Thr Val Arg Asp Trp Thr Leu 

            500                 505                 510         





Glu Asp Ser Ser Gln Glu Leu Trp Lys 

        515                 520     





<210>  47

<211>  4147

<212>  DNA

<213>  Mus musculus



<400>  47

aggctgcggc cgccgctggg ctgctgccat ggggagccgt tgaaagagtg gggccctgtg       60



gctcggccgc gcgcctcagg ctgccagcgc gggcgggggg cggcgggggc gcgcggggcc      120



cgggccgggg ccggcgggcg ggcgggggcc ggcggaggac gcccacaagt ccagcggcgg      180



cggcggcggc agaggaggag gaggaggagg acgcggcggg gacgcggcga ctcgggccgc      240



tccgtaacct ccgagggtcc gcggtagcgg tggacgggtc gatccgtgga gtggatgtct      300



tcgggccatt gcggtgcttg ggactcatta aactgtcact cacccccacc accaccccac      360



tggtatttca gaagtgcagt ttgagtttgt tgatgctgaa agtggaaatt tgcactaacg      420



gtggcagtgt gaactatttt cctgagaggt agatccagat aaattgctta ggttatgaag      480



acagtatgga gtttccagac cacagcagac atttgctgca gtgtctgagc gagcagaggc      540



accagggctt tctttgtgac tgcactgttc tggtgggaga tgcccagttc cgggcacacc      600



gagctgttct ggcttcatgc agcatgtatt tccacctctt ttacaaggac cagctggaca      660



aaagagacat tgttcatctg aacagcgaca ttgtgacagc ccccgctttc gctctcctgc      720



ttgaattcat gtacgaaggg aaactccagt tcaaagactt gcccattgag gacgtgctag      780



cagctgccag ttatctccac atgtatgaca ttgtcaaagt ctgcaaaaag aagctgaaag      840



agaaagctac cacagaggcg gacagcacca aaaaagaaga agatgcttca agttgttcgg      900



ataaagtcga gagcctctca gacggcagca gccacatggc aggtgacctg cccagtgatg      960



aagatgaagg cgaagatgac aaattgaaca ttctacccag caaaagggac ttggcagctg     1020



agcctgggaa catgtggatg cgattgccct cagactcagc aggcatcccc caggctggcg     1080



gagaggccga gccacacgcc acagcagctg gaaaaacagt agccagcccc tgcagctcaa     1140



cagagtcttt gtcccagagg tctgtcacct ccgtgaggga ttcggcagat gttgactgtg     1200



tgctggacct gtctgtcaag tccagccttt caggagttga aaatctgaac agctcttatt     1260



tctcttcaca ggacgtgctg agaagcaacc tggtgcaggt gaaggtggag aaagaggcgt     1320



cctgtgatga gagtgatgtt ggcactaatg actatgacat ggaacatagc actgtgaaag     1380



agagtgtgag cactaacaac agggtacagt atgagccagc ccacctggct cctctgaggg     1440



aggactcggt cttaagggaa ctggatcggg aggacaaagc cagcgatgat gagatgatga     1500



ccccagagag cgagcgggtc caggtggaag ggggcatgga gaacagtctg cttccctacg     1560



tctccaatat cctgagcccc gcaggccaga tcttcatgtg ccccctgtgc aacaaagtct     1620



tccccagccc ccacatcctg cagatccacc tgagcacgca cttccgagag caggatggca     1680



tccgtagcaa gcctgccgcc gatgtcaatg tgcccacgtg ctccctgtgt gggaagactt     1740



tctcctgcat gtacaccctc aagcgccacg agaggactca ctcgggggag aagccctaca     1800



cgtgcaccca atgcggcaag agtttccagt actcgcacaa cctgagccgt catgccgtgg     1860



tgcacacccg cgagaagccc catgcctgca agtggtgcga gcgcaggttc acgcagtccg     1920



gagacctgta cagacacatc cgcaagttcc actgtgagtt ggtgaactcc ttgtcggtca     1980



aaagtgaagc gctgagcttg cccactgtca gagactggac cttagaagat agctctcaag     2040



aactttggaa ataattttat atatatatat atataaataa tatatatata tatatataca     2100



tatatataca tagatctcta tatagttgtg gtacggtcta aaagcagtct tgtttcctgg     2160



aactgaaaag ttgggatctt aacttgtttt tgcactttag aataatagca tgagaatctc     2220



actaatttag cattctgata aaagaaacta gagcaagtca caagtagaga gctgtctttc     2280



ttttgagggt taggccaagt tagccaataa aaccttctca acaaatggtt ctgtcacaaa     2340



cgctttcaca tggcttactt ttgtacacac tgcattgtct tgagcgcttt ccctgtgctc     2400



cacactgttt tgttttgttt tgttttcaga gtagaaatcc cctccagttt attagcctct     2460



ttatatgtct caaattgcat gaatattttc tggctgttgg aaacctgaat gcttttagac     2520



ccaaatggaa aatttctgaa atgctggatt atctattttt aaacaagcag ttgacttaaa     2580



actttgtgtg gcaacttctg gttttctgat ggtccccagt gagagaaatc tgacagtaca     2640



ctgggtcact gggactgtct ctgtgaaggt ttgcttgaga tgaaaaagga tattgcagct     2700



tcagcagtgt tgaactgtgt gtttaaaatg tgaattactg ttcttgtata ctgtaattga     2760



ttacacgggc tggggggggt gtcaaagaac ttgacaggtt gtgttgatgc tcttagttga     2820



gtcttgaaaa gtaaatatta acgctacaga aatgcatgag tttcaatata ttttttgtct     2880



ttgtttgcat tgtataactt taacgagtga gtttaaaatt atttaatttc cttagaaaaa     2940



tagcaccatt tgggaaaaaa actggtgtta cgaagaacat aaatgcactg tctttatttt     3000



tatttttatt ttatataatt taaattgact tttcccacgt ctttaagttt gaaactgtta     3060



agctgaataa aaacttaagc tgcaaattga taacttcgct acattacaag gaacatataa     3120



atgtttacaa acggcttaaa gaattgcatg tgcagtgtgc attcatacca cacttgtaat     3180



tgcacagaac ccatgccagc tcagagttta ggtgtacaca cgtacccagc cgagtgtttt     3240



tagaataact actgcacaaa ttgacaatag gtcataggtc attctctctc tccctccttt     3300



ttgcttcccc tttctttttc tcccctattt cctttccttc cccctacccc ctaactcatg     3360



aaaagattct atggactgaa aaagccccag gctgaaagga ctgaaccgcc ttgattgaca     3420



tggggagggg ggttagtaga ctgtgtatcg gcagcagagg ctgcagcccg atgtgtggtt     3480



ctgatggcca gcgcggggca gaagcgtttt gcacactgtt tgttttcctg tcttgcactt     3540



acaaataagg tctatgggag tagcatggga aacagtggtt gtttttccct ttttcttttt     3600



taattgcttt tgtttaaaat ttgatcgcct taactactgt aaacatagcc tatttttgtg     3660



cttaagatac tgaatggaaa actccattgt gtgttgctgg actgttttgg aaatatttgg     3720



tcaaatgtat gttaatttgg ctgtaatggc atttaaagca aacaaacaaa caaacaaaca     3780



aagctgtgaa aatggccttg gagcattatc tttagttact tgaagagttt ctagtttttt     3840



tttttttaat acagtttatg ttaaaataat ctttattaat ctagaggaga caatcaatgt     3900



ctgtggaaga acggactttt ttggattttc ttttttaatg gtcattgtga gtgattgctc     3960



tttcttttac ttagtttcac attcttcctt tgttctaaat cttagactga catctagctt     4020



tgacaatcat agtatgtttt atttcctgag ggggaataac ttataatgct gtttagtttt     4080



gtactattgg tgtgttggtg aatttttaaa ctgtgtgcta actgcaataa attatatgaa     4140



ctgagaa                                                               4147





<210>  48

<211>  522

<212>  PRT

<213>  Mus musculus



<400>  48



Met Glu Phe Pro Asp His Ser Arg His Leu Leu Gln Cys Leu Ser Glu 

1               5                   10                  15      





Gln Arg His Gln Gly Phe Leu Cys Asp Cys Thr Val Leu Val Gly Asp 

            20                  25                  30          





Ala Gln Phe Arg Ala His Arg Ala Val Leu Ala Ser Cys Ser Met Tyr 

        35                  40                  45              





Phe His Leu Phe Tyr Lys Asp Gln Leu Asp Lys Arg Asp Ile Val His 

    50                  55                  60                  





Leu Asn Ser Asp Ile Val Thr Ala Pro Ala Phe Ala Leu Leu Leu Glu 

65                  70                  75                  80  





Phe Met Tyr Glu Gly Lys Leu Gln Phe Lys Asp Leu Pro Ile Glu Asp 

                85                  90                  95      





Val Leu Ala Ala Ala Ser Tyr Leu His Met Tyr Asp Ile Val Lys Val 

            100                 105                 110         





Cys Lys Lys Lys Leu Lys Glu Lys Ala Thr Thr Glu Ala Asp Ser Thr 

        115                 120                 125             





Lys Lys Glu Glu Asp Ala Ser Ser Cys Ser Asp Lys Val Glu Ser Leu 

    130                 135                 140                 





Ser Asp Gly Ser Ser His Met Ala Gly Asp Leu Pro Ser Asp Glu Asp 

145                 150                 155                 160 





Glu Gly Glu Asp Asp Lys Leu Asn Ile Leu Pro Ser Lys Arg Asp Leu 

                165                 170                 175     





Ala Ala Glu Pro Gly Asn Met Trp Met Arg Leu Pro Ser Asp Ser Ala 

            180                 185                 190         





Gly Ile Pro Gln Ala Gly Gly Glu Ala Glu Pro His Ala Thr Ala Ala 

        195                 200                 205             





Gly Lys Thr Val Ala Ser Pro Cys Ser Ser Thr Glu Ser Leu Ser Gln 

    210                 215                 220                 





Arg Ser Val Thr Ser Val Arg Asp Ser Ala Asp Val Asp Cys Val Leu 

225                 230                 235                 240 





Asp Leu Ser Val Lys Ser Ser Leu Ser Gly Val Glu Asn Leu Asn Ser 

                245                 250                 255     





Ser Tyr Phe Ser Ser Gln Asp Val Leu Arg Ser Asn Leu Val Gln Val 

            260                 265                 270         





Lys Val Glu Lys Glu Ala Ser Cys Asp Glu Ser Asp Val Gly Thr Asn 

        275                 280                 285             





Asp Tyr Asp Met Glu His Ser Thr Val Lys Glu Ser Val Ser Thr Asn 

    290                 295                 300                 





Asn Arg Val Gln Tyr Glu Pro Ala His Leu Ala Pro Leu Arg Glu Asp 

305                 310                 315                 320 





Ser Val Leu Arg Glu Leu Asp Arg Glu Asp Lys Ala Ser Asp Asp Glu 

                325                 330                 335     





Met Met Thr Pro Glu Ser Glu Arg Val Gln Val Glu Gly Gly Met Glu 

            340                 345                 350         





Asn Ser Leu Leu Pro Tyr Val Ser Asn Ile Leu Ser Pro Ala Gly Gln 

        355                 360                 365             





Ile Phe Met Cys Pro Leu Cys Asn Lys Val Phe Pro Ser Pro His Ile 

    370                 375                 380                 





Leu Gln Ile His Leu Ser Thr His Phe Arg Glu Gln Asp Gly Ile Arg 

385                 390                 395                 400 





Ser Lys Pro Ala Ala Asp Val Asn Val Pro Thr Cys Ser Leu Cys Gly 

                405                 410                 415     





Lys Thr Phe Ser Cys Met Tyr Thr Leu Lys Arg His Glu Arg Thr His 

            420                 425                 430         





Ser Gly Glu Lys Pro Tyr Thr Cys Thr Gln Cys Gly Lys Ser Phe Gln 

        435                 440                 445             





Tyr Ser His Asn Leu Ser Arg His Ala Val Val His Thr Arg Glu Lys 

    450                 455                 460                 





Pro His Ala Cys Lys Trp Cys Glu Arg Arg Phe Thr Gln Ser Gly Asp 

465                 470                 475                 480 





Leu Tyr Arg His Ile Arg Lys Phe His Cys Glu Leu Val Asn Ser Leu 

                485                 490                 495     





Ser Val Lys Ser Glu Ala Leu Ser Leu Pro Thr Val Arg Asp Trp Thr 

            500                 505                 510         





Leu Glu Asp Ser Ser Gln Glu Leu Trp Lys 

        515                 520         





<210>  49

<211>  3810

<212>  DNA

<213>  Mus musculus



<400>  49

atgaagtgat ggtcttactg gattgaaagt cttgggcttg cttggtttac gattttattt       60



cttctatttg agcaagtaaa taactttaat acacaaaaat atttcaagtt ttcagatggt      120



tatgaagaca gtatggagtt tccagaccac agcagacatt tgctgcagtg tctgagcgag      180



cagaggcacc agggctttct ttgtgactgc actgttctgg tgggagatgc ccagttccgg      240



gcacaccgag ctgttctggc ttcatgcagc atgtatttcc acctctttta caaggaccag      300



ctggacaaaa gagacattgt tcatctgaac agcgacattg tgacagcccc cgctttcgct      360



ctcctgcttg aattcatgta cgaagggaaa ctccagttca aagacttgcc cattgaggac      420



gtgctagcag ctgccagtta tctccacatg tatgacattg tcaaagtctg caaaaagaag      480



ctgaaagaga aagctaccac agaggcggac agcaccaaaa aagaagaaga tgcttcaagt      540



tgttcggata aagtcgagag cctctcagac ggcagcagcc acatggcagg tgacctgccc      600



agtgatgaag atgaaggcga agatgacaaa ttgaacattc tacccagcaa aagggacttg      660



gcagctgagc ctgggaacat gtggatgcga ttgccctcag actcagcagg catcccccag      720



gctggcggag aggccgagcc acacgccaca gcagctggaa aaacagtagc cagcccctgc      780



agctcaacag agtctttgtc ccagaggtct gtcacctccg tgagggattc ggcagatgtt      840



gactgtgtgc tggacctgtc tgtcaagtcc agcctttcag gagttgaaaa tctgaacagc      900



tcttatttct cttcacagga cgtgctgaga agcaacctgg tgcaggtgaa ggtggagaaa      960



gaggcgtcct gtgatgagag tgatgttggc actaatgact atgacatgga acatagcact     1020



gtgaaagaga gtgtgagcac taacaacagg gtacagtatg agccagccca cctggctcct     1080



ctgagggagg actcggtctt aagggaactg gatcgggagg acaaagccag cgatgatgag     1140



atgatgaccc cagagagcga gcgggtccag gtggaagggg gcatggagaa cagtctgctt     1200



ccctacgtct ccaatatcct gagccccgca ggccagatct tcatgtgccc cctgtgcaac     1260



aaagtcttcc ccagccccca catcctgcag atccacctga gcacgcactt ccgagagcag     1320



gatggcatcc gtagcaagcc tgccgccgat gtcaatgtgc ccacgtgctc cctgtgtggg     1380



aagactttct cctgcatgta caccctcaag cgccacgaga ggactcactc gggggagaag     1440



ccctacacgt gcacccaatg cggcaagagt ttccagtact cgcacaacct gagccgtcat     1500



gccgtggtgc acacccgcga gaagccccat gcctgcaagt ggtgcgagcg caggttcacg     1560



cagtccggag acctgtacag acacatccgc aagttccact gtgagttggt gaactccttg     1620



tcggtcaaaa gtgaagcgct gagcttgccc actgtcagag actggacctt agaagatagc     1680



tctcaagaac tttggaaata attttatata tatatatata taaataatat atatatatat     1740



atatacatat atatacatag atctctatat agttgtggta cggtctaaaa gcagtcttgt     1800



ttcctggaac tgaaaagttg ggatcttaac ttgtttttgc actttagaat aatagcatga     1860



gaatctcact aatttagcat tctgataaaa gaaactagag caagtcacaa gtagagagct     1920



gtctttcttt tgagggttag gccaagttag ccaataaaac cttctcaaca aatggttctg     1980



tcacaaacgc tttcacatgg cttacttttg tacacactgc attgtcttga gcgctttccc     2040



tgtgctccac actgttttgt tttgttttgt tttcagagta gaaatcccct ccagtttatt     2100



agcctcttta tatgtctcaa attgcatgaa tattttctgg ctgttggaaa cctgaatgct     2160



tttagaccca aatggaaaat ttctgaaatg ctggattatc tatttttaaa caagcagttg     2220



acttaaaact ttgtgtggca acttctggtt ttctgatggt ccccagtgag agaaatctga     2280



cagtacactg ggtcactggg actgtctctg tgaaggtttg cttgagatga aaaaggatat     2340



tgcagcttca gcagtgttga actgtgtgtt taaaatgtga attactgttc ttgtatactg     2400



taattgatta cacgggctgg ggggggtgtc aaagaacttg acaggttgtg ttgatgctct     2460



tagttgagtc ttgaaaagta aatattaacg ctacagaaat gcatgagttt caatatattt     2520



tttgtctttg tttgcattgt ataactttaa cgagtgagtt taaaattatt taatttcctt     2580



agaaaaatag caccatttgg gaaaaaaact ggtgttacga agaacataaa tgcactgtct     2640



ttatttttat ttttatttta tataatttaa attgactttt cccacgtctt taagtttgaa     2700



actgttaagc tgaataaaaa cttaagctgc aaattgataa cttcgctaca ttacaaggaa     2760



catataaatg tttacaaacg gcttaaagaa ttgcatgtgc agtgtgcatt cataccacac     2820



ttgtaattgc acagaaccca tgccagctca gagtttaggt gtacacacgt acccagccga     2880



gtgtttttag aataactact gcacaaattg acaataggtc ataggtcatt ctctctctcc     2940



ctcctttttg cttccccttt ctttttctcc cctatttcct ttccttcccc ctacccccta     3000



actcatgaaa agattctatg gactgaaaaa gccccaggct gaaaggactg aaccgccttg     3060



attgacatgg ggaggggggt tagtagactg tgtatcggca gcagaggctg cagcccgatg     3120



tgtggttctg atggccagcg cggggcagaa gcgttttgca cactgtttgt tttcctgtct     3180



tgcacttaca aataaggtct atgggagtag catgggaaac agtggttgtt tttccctttt     3240



tcttttttaa ttgcttttgt ttaaaatttg atcgccttaa ctactgtaaa catagcctat     3300



ttttgtgctt aagatactga atggaaaact ccattgtgtg ttgctggact gttttggaaa     3360



tatttggtca aatgtatgtt aatttggctg taatggcatt taaagcaaac aaacaaacaa     3420



acaaacaaag ctgtgaaaat ggccttggag cattatcttt agttacttga agagtttcta     3480



gttttttttt ttttaataca gtttatgtta aaataatctt tattaatcta gaggagacaa     3540



tcaatgtctg tggaagaacg gacttttttg gattttcttt tttaatggtc attgtgagtg     3600



attgctcttt cttttactta gtttcacatt cttcctttgt tctaaatctt agactgacat     3660



ctagctttga caatcatagt atgttttatt tcctgagggg gaataactta taatgctgtt     3720



tagttttgta ctattggtgt gttggtgaat ttttaaactg tgtgctaact gcaataaatt     3780



atatgaactg agaaaaaaaa aaaaaaaaaa                                      3810





<210>  50

<211>  531

<212>  PRT

<213>  Homo sapiens



<400>  50



Met Cys Pro Lys Gly Tyr Glu Asp Ser Met Glu Phe Pro Asp His Ser 

1               5                   10                  15      





Arg His Leu Leu Gln Cys Leu Ser Glu Gln Arg His Gln Gly Phe Leu 

            20                  25                  30          





Cys Asp Cys Thr Val Leu Val Gly Asp Ala Gln Phe Arg Ala His Arg 

        35                  40                  45              





Ala Val Leu Ala Ser Cys Ser Met Tyr Phe His Leu Phe Tyr Lys Asp 

    50                  55                  60                  





Gln Leu Asp Lys Arg Asp Ile Val His Leu Asn Ser Asp Ile Val Thr 

65                  70                  75                  80  





Ala Pro Ala Phe Ala Leu Leu Leu Glu Phe Met Tyr Glu Gly Lys Leu 

                85                  90                  95      





Gln Phe Lys Asp Leu Pro Ile Glu Asp Val Leu Ala Ala Ala Ser Tyr 

            100                 105                 110         





Leu His Met Tyr Asp Ile Val Lys Val Cys Lys Lys Lys Leu Lys Glu 

        115                 120                 125             





Lys Ala Thr Thr Glu Ala Asp Ser Thr Lys Lys Glu Glu Asp Ala Ser 

    130                 135                 140                 





Ser Cys Ser Asp Lys Val Glu Ser Leu Ser Asp Gly Ser Ser His Ile 

145                 150                 155                 160 





Ala Gly Asp Leu Pro Ser Asp Glu Asp Glu Gly Glu Asp Glu Lys Leu 

                165                 170                 175     





Asn Ile Leu Pro Ser Lys Arg Asp Leu Ala Ala Glu Pro Gly Asn Met 

            180                 185                 190         





Trp Met Arg Leu Pro Ser Asp Ser Ala Gly Ile Pro Gln Ala Gly Gly 

        195                 200                 205             





Glu Ala Glu Pro His Ala Thr Ala Ala Gly Lys Thr Val Ala Ser Pro 

    210                 215                 220                 





Cys Ser Ser Thr Glu Ser Leu Ser Gln Arg Ser Val Thr Ser Val Arg 

225                 230                 235                 240 





Asp Ser Ala Asp Val Asp Cys Val Leu Asp Leu Ser Val Lys Ser Ser 

                245                 250                 255     





Leu Ser Gly Val Glu Asn Leu Asn Ser Ser Tyr Phe Ser Ser Gln Asp 

            260                 265                 270         





Val Leu Arg Ser Asn Leu Val Gln Val Lys Val Glu Lys Glu Ala Ser 

        275                 280                 285             





Cys Asp Glu Ser Asp Val Gly Thr Asn Asp Tyr Asp Met Glu His Ser 

    290                 295                 300                 





Thr Val Lys Glu Ser Val Ser Thr Asn Asn Arg Val Gln Tyr Glu Pro 

305                 310                 315                 320 





Ala His Leu Ala Pro Leu Arg Glu Asp Ser Val Leu Arg Glu Leu Asp 

                325                 330                 335     





Arg Glu Asp Lys Ala Ser Asp Asp Glu Met Met Thr Pro Glu Ser Glu 

            340                 345                 350         





Arg Val Gln Val Glu Gly Gly Met Glu Ser Ser Leu Leu Pro Tyr Val 

        355                 360                 365             





Ser Asn Ile Leu Ser Pro Ala Gly Gln Ile Phe Met Cys Pro Leu Cys 

    370                 375                 380                 





Asn Lys Val Phe Pro Ser Pro His Ile Leu Gln Ile His Leu Ser Thr 

385                 390                 395                 400 





His Phe Arg Glu Gln Asp Gly Ile Arg Ser Lys Pro Ala Ala Asp Val 

                405                 410                 415     





Asn Val Pro Thr Cys Ser Leu Cys Gly Lys Thr Phe Ser Cys Met Tyr 

            420                 425                 430         





Thr Leu Lys Arg His Glu Arg Thr His Ser Gly Glu Lys Pro Tyr Thr 

        435                 440                 445             





Cys Thr Gln Cys Gly Lys Ser Phe Gln Tyr Ser His Asn Leu Ser Arg 

    450                 455                 460                 





His Ala Val Val His Thr Arg Glu Lys Pro His Ala Cys Lys Trp Cys 

465                 470                 475                 480 





Glu Arg Arg Phe Thr Gln Ser Gly Asp Leu Tyr Arg His Ile Arg Lys 

                485                 490                 495     





Phe His Cys Glu Leu Val Asn Ser Leu Ser Val Lys Ser Glu Ala Leu 

            500                 505                 510         





Ser Leu Pro Thr Val Arg Asp Trp Thr Leu Glu Asp Ser Ser Gln Glu 

        515                 520                 525             





Leu Trp Lys 

    530     





<210>  51

<211>  3851

<212>  DNA

<213>  Homo sapiens



<400>  51

agtgtgtgcg gatctgtggt ggagaaggta tctcattcct ctctaacatc atctccactt       60



tgcatctgtc tctcttagtc tgcttttttt ccaccgatgt aacagacctg gagccagcag      120



gactcagagg aaaggactta atcaggttta tgtgtcctaa aggttatgaa gacagtatgg      180



agtttccaga ccatagtaga catttgctac agtgtctgag cgagcagaga caccagggtt      240



ttctttgtga ctgcactgtt ctggtgggag atgcccagtt ccgagcgcac cgagctgtac      300



tggcttcatg cagcatgtat ttccacctct tttacaagga ccagctggac aaaagagaca      360



ttgttcatct gaacagcgac attgttacag cccccgcttt cgctctcctg cttgaattca      420



tgtatgaagg gaaactccag ttcaaagact tgcccattga agacgtgcta gcagctgcca      480



gttatctcca catgtatgac attgtcaaag tctgcaaaaa gaagctgaaa gagaaagcca      540



ccacggaggc agacagcacc aaaaaggaag aagatgcttc aagttgttcg gacaaagtcg      600



agagtctctc cgatggcagc agccacatag caggcgattt gcccagtgat gaagatgaag      660



gagaagatga aaaattgaac atcctgccca gcaaaaggga cttggcggcc gagcctggga      720



acatgtggat gcgattgccc tcagactcag caggcatccc ccaggctggc ggagaggcag      780



agccacacgc cacagcagct ggaaaaacag tagccagccc ctgcagctca acagagtctt      840



tgtcccagag gtctgtcacc tccgtgaggg attcggcaga tgttgactgt gtgctggacc      900



tgtctgtcaa gtccagcctt tcaggagttg aaaatctgaa cagctcttat ttctcttcac      960



aggacgtgct gagaagcaac ctggtgcagg tgaaggtgga gaaagaggct tcctgtgatg     1020



agagtgatgt tggcactaat gactatgaca tggaacatag cactgtgaaa gaaagtgtga     1080



gcactaataa cagggtacag tatgagccgg cccatctggc tcccctgagg gaggactcgg     1140



tcttgaggga gctggaccgg gaggacaaag ccagtgatga tgagatgatg accccagaga     1200



gcgagcgtgt ccaggtggag ggaggcatgg agagcagtct gctcccctac gtctccaaca     1260



tcctgagccc cgcgggccag atcttcatgt gccccctgtg caacaaggtc ttccccagcc     1320



cccacatcct gcagatccac ctgagcacgc acttccgcga gcaggacggc atccgcagca     1380



agcccgccgc cgatgtcaac gtgcccacgt gctcgctgtg tgggaagact ttctcttgca     1440



tgtacaccct caagcgccac gagaggactc actcggggga gaagccctac acatgcaccc     1500



agtgcggcaa gagcttccag tactcgcaca acctgagccg ccatgccgtg gtgcacaccc     1560



gcgagaagcc gcacgcctgc aagtggtgcg agcgcaggtt cacgcagtcc ggggacctgt     1620



acagacacat tcgcaagttc cactgtgagt tggtgaactc cttgtcggtc aaaagcgaag     1680



cactgagctt gcctactgtc agagactgga ccttagaaga tagctctcaa gaactttgga     1740



aataatttta tatatatata aataatatat atatatatac atatatataa atagatctct     1800



atatagttgt ggtacggtct aaaagcagtc ttgtttcctg gaaataaaaa gttgggatat     1860



taacttgttt ttgcacttta gaatagcatg agaatctcac taatttagca ttctgataaa     1920



agaaacttta gagcaagtca gaatagagag gtgtttttcc tttgagggga taggggaagt     1980



aagccaataa gaacctttta aacaaatcgt cctgtcacaa aatgctttca tatggcttaa     2040



ttttgtcaac actgcattgt cttttgagct cttttttccc ccccaacaaa gtttttttgt     2100



tttttgtttt tttttttaag tagaaattcc ctccagtttt attagcctct ttatatgtct     2160



caaattgcat gaattttttc tggctgttgg aaacctgaat gcttttagac ccaaatggaa     2220



aatttctgaa atgctggatt atctattttt aaacaagcag ttgacttaaa actttctgtg     2280



gcaacttctg gttttctgac agttcccagt gagagaaatg ctgaaagtac actgggatca     2340



ctgggacact gtcttatgaa ggtttgcttg ggatgaaaaa ggatattgca gcttcagcag     2400



tgttgaactg tgtgtttaaa aatgtgaatt actgttattg tatactgtaa ttgattacat     2460



gggctggggg ggtgtcaaag aacttgacag gttgtgttga tgctcttagt tgagtcttga     2520



aaagtaaata ttaacgctac agaaatgcat gagtttcaat atattttttg tctttgtttg     2580



cattgtataa ctttaacgag tgagtttaaa attatttaat ttccttagaa aaataacacc     2640



atttggaaaa aaaaactggt gttatgaaga acgtaaatgc actgttttta tttttatttt     2700



atataattta aattgacttt cccactgtct ttaagttgaa actgttaagc tgaataaaaa     2760



cttaagctgc aaattgataa cttcgctaca taacaaggaa aatataaatg tttacaaaca     2820



gcttaaagat ttgcatgtgc agtgtgcatt tataacaaac ttctaattgc acaaaaccca     2880



tgccagctca gagtttaggt gtacacattt acccagttga gcgttcttag aataactact     2940



gcacaagttg acaataggtc gttctctctt tttttttgtt tgctcccttt ttctttttct     3000



ccccttcctc cttaccctcc ctcccttact ctcccccccc accaccaccc tccaccccca     3060



actcatgaaa agattctatg gactgaaaaa gccccaggct gaaaggactg gactgccttg     3120



attgacatgg ggaagggggt tagtagacta tgtggattgc ggcagcagag gctgcagcct     3180



aacgtgtggt tttaatgacc agcacgcaag gcaaaagcat tttgcacagt gtttgttttc     3240



ctgtcttgca cttacaaata aggtctatgg gagtagcatg gaaaacgttt gctgtttttc     3300



cctttttttt ttaattgctt ttgtttaaaa tttgatcgcc ttaactactg taaacatagc     3360



ctatttttgt gcttaagata ctgaatggaa aactccattg tgtgttgctg gactgttttg     3420



gaaatatttg gttaaatgtg tgttaatttg gctgtaatgg catttaaagc aaacaaacaa     3480



acaaaaaaag ctgtgaaaat ggccttggag cattatcttt agttacttga agagtttcta     3540



gtttttttaa aatacagttt atgttaaaat aatttttatt aatttagaga agacaatcaa     3600



tgtctgtgag aaaacggact ttcttttgga ttttcttttt gtggtcattg tgagtgattg     3660



ctttttcctt ttcttagttt cacattcttc ctttgttcta aaacttagac tgacatctag     3720



ctttgacaat catagtatgt tttattttcc tgagggggaa taacttataa tgctgtttag     3780



ttttgtacta ttggtgtgtt ggtgaatttt taaactgtgt gctaactgca ataaattata     3840



tgaactgaga a                                                          3851





<210>  52

<211>  522

<212>  PRT

<213>  Homo sapiens



<400>  52



Met Glu Phe Pro Asp His Ser Arg His Leu Leu Gln Cys Leu Ser Glu 

1               5                   10                  15      





Gln Arg His Gln Gly Phe Leu Cys Asp Cys Thr Val Leu Val Gly Asp 

            20                  25                  30          





Ala Gln Phe Arg Ala His Arg Ala Val Leu Ala Ser Cys Ser Met Tyr 

        35                  40                  45              





Phe His Leu Phe Tyr Lys Asp Gln Leu Asp Lys Arg Asp Ile Val His 

    50                  55                  60                  





Leu Asn Ser Asp Ile Val Thr Ala Pro Ala Phe Ala Leu Leu Leu Glu 

65                  70                  75                  80  





Phe Met Tyr Glu Gly Lys Leu Gln Phe Lys Asp Leu Pro Ile Glu Asp 

                85                  90                  95      





Val Leu Ala Ala Ala Ser Tyr Leu His Met Tyr Asp Ile Val Lys Val 

            100                 105                 110         





Cys Lys Lys Lys Leu Lys Glu Lys Ala Thr Thr Glu Ala Asp Ser Thr 

        115                 120                 125             





Lys Lys Glu Glu Asp Ala Ser Ser Cys Ser Asp Lys Val Glu Ser Leu 

    130                 135                 140                 





Ser Asp Gly Ser Ser His Ile Ala Gly Asp Leu Pro Ser Asp Glu Asp 

145                 150                 155                 160 





Glu Gly Glu Asp Glu Lys Leu Asn Ile Leu Pro Ser Lys Arg Asp Leu 

                165                 170                 175     





Ala Ala Glu Pro Gly Asn Met Trp Met Arg Leu Pro Ser Asp Ser Ala 

            180                 185                 190         





Gly Ile Pro Gln Ala Gly Gly Glu Ala Glu Pro His Ala Thr Ala Ala 

        195                 200                 205             





Gly Lys Thr Val Ala Ser Pro Cys Ser Ser Thr Glu Ser Leu Ser Gln 

    210                 215                 220                 





Arg Ser Val Thr Ser Val Arg Asp Ser Ala Asp Val Asp Cys Val Leu 

225                 230                 235                 240 





Asp Leu Ser Val Lys Ser Ser Leu Ser Gly Val Glu Asn Leu Asn Ser 

                245                 250                 255     





Ser Tyr Phe Ser Ser Gln Asp Val Leu Arg Ser Asn Leu Val Gln Val 

            260                 265                 270         





Lys Val Glu Lys Glu Ala Ser Cys Asp Glu Ser Asp Val Gly Thr Asn 

        275                 280                 285             





Asp Tyr Asp Met Glu His Ser Thr Val Lys Glu Ser Val Ser Thr Asn 

    290                 295                 300                 





Asn Arg Val Gln Tyr Glu Pro Ala His Leu Ala Pro Leu Arg Glu Asp 

305                 310                 315                 320 





Ser Val Leu Arg Glu Leu Asp Arg Glu Asp Lys Ala Ser Asp Asp Glu 

                325                 330                 335     





Met Met Thr Pro Glu Ser Glu Arg Val Gln Val Glu Gly Gly Met Glu 

            340                 345                 350         





Ser Ser Leu Leu Pro Tyr Val Ser Asn Ile Leu Ser Pro Ala Gly Gln 

        355                 360                 365             





Ile Phe Met Cys Pro Leu Cys Asn Lys Val Phe Pro Ser Pro His Ile 

    370                 375                 380                 





Leu Gln Ile His Leu Ser Thr His Phe Arg Glu Gln Asp Gly Ile Arg 

385                 390                 395                 400 





Ser Lys Pro Ala Ala Asp Val Asn Val Pro Thr Cys Ser Leu Cys Gly 

                405                 410                 415     





Lys Thr Phe Ser Cys Met Tyr Thr Leu Lys Arg His Glu Arg Thr His 

            420                 425                 430         





Ser Gly Glu Lys Pro Tyr Thr Cys Thr Gln Cys Gly Lys Ser Phe Gln 

        435                 440                 445             





Tyr Ser His Asn Leu Ser Arg His Ala Val Val His Thr Arg Glu Lys 

    450                 455                 460                 





Pro His Ala Cys Lys Trp Cys Glu Arg Arg Phe Thr Gln Ser Gly Asp 

465                 470                 475                 480 





Leu Tyr Arg His Ile Arg Lys Phe His Cys Glu Leu Val Asn Ser Leu 

                485                 490                 495     





Ser Val Lys Ser Glu Ala Leu Ser Leu Pro Thr Val Arg Asp Trp Thr 

            500                 505                 510         





Leu Glu Asp Ser Ser Gln Glu Leu Trp Lys 

        515                 520         





<210>  53

<211>  4319

<212>  DNA

<213>  Homo sapiens



<400>  53

gttgtttgct aatttctgga ctaattatgc aatttcattt ttttttcttg attcagccaa       60



atgtgtgtgt gtgtgtttaa actgtgcttt ctaagcacag tcaggtagca aaagtaataa      120



aaaggatggt tgaacaagtt ttcttgtatg ttccaggata tgtttgggac ttttctttgt      180



ttattatatg agttgttccc tttgaaatta aagctatttt gtaggttttg tgggacataa      240



tttgataagt agagttaatt aaatttcttc tggaagagat ctaaattctt attcttagtg      300



agagactgta gttaaaggaa ggcttttaga acttgggttc aaggaagatg gagatgcgtc      360



ggaagctctt tggcgggggt gaggaagttc agaaagtgtg cattttcctt ctggcattta      420



ggtcttgtcc gtgtgatttg gtggtgcttg ggtcataagc ctgattaaaa ttcagggaca      480



tgtaccacgg cggccaaagc ggaattaatt tttttatatg gggactggag cgctgaaaag      540



ttgttcctga ccaggctcta atgagaaatt cctctctccc caggttatga agacagtatg      600



gagtttccag accatagtag acatttgcta cagtgtctga gcgagcagag acaccagggt      660



tttctttgtg actgcactgt tctggtggga gatgcccagt tccgagcgca ccgagctgta      720



ctggcttcat gcagcatgta tttccacctc ttttacaagg accagctgga caaaagagac      780



attgttcatc tgaacagcga cattgttaca gcccccgctt tcgctctcct gcttgaattc      840



atgtatgaag ggaaactcca gttcaaagac ttgcccattg aagacgtgct agcagctgcc      900



agttatctcc acatgtatga cattgtcaaa gtctgcaaaa agaagctgaa agagaaagcc      960



accacggagg cagacagcac caaaaaggaa gaagatgctt caagttgttc ggacaaagtc     1020



gagagtctct ccgatggcag cagccacata gcaggcgatt tgcccagtga tgaagatgaa     1080



ggagaagatg aaaaattgaa catcctgccc agcaaaaggg acttggcggc cgagcctggg     1140



aacatgtgga tgcgattgcc ctcagactca gcaggcatcc cccaggctgg cggagaggca     1200



gagccacacg ccacagcagc tggaaaaaca gtagccagcc cctgcagctc aacagagtct     1260



ttgtcccaga ggtctgtcac ctccgtgagg gattcggcag atgttgactg tgtgctggac     1320



ctgtctgtca agtccagcct ttcaggagtt gaaaatctga acagctctta tttctcttca     1380



caggacgtgc tgagaagcaa cctggtgcag gtgaaggtgg agaaagaggc ttcctgtgat     1440



gagagtgatg ttggcactaa tgactatgac atggaacata gcactgtgaa agaaagtgtg     1500



agcactaata acagggtaca gtatgagccg gcccatctgg ctcccctgag ggaggactcg     1560



gtcttgaggg agctggaccg ggaggacaaa gccagtgatg atgagatgat gaccccagag     1620



agcgagcgtg tccaggtgga gggaggcatg gagagcagtc tgctccccta cgtctccaac     1680



atcctgagcc ccgcgggcca gatcttcatg tgccccctgt gcaacaaggt cttccccagc     1740



ccccacatcc tgcagatcca cctgagcacg cacttccgcg agcaggacgg catccgcagc     1800



aagcccgccg ccgatgtcaa cgtgcccacg tgctcgctgt gtgggaagac tttctcttgc     1860



atgtacaccc tcaagcgcca cgagaggact cactcggggg agaagcccta cacatgcacc     1920



cagtgcggca agagcttcca gtactcgcac aacctgagcc gccatgccgt ggtgcacacc     1980



cgcgagaagc cgcacgcctg caagtggtgc gagcgcaggt tcacgcagtc cggggacctg     2040



tacagacaca ttcgcaagtt ccactgtgag ttggtgaact ccttgtcggt caaaagcgaa     2100



gcactgagct tgcctactgt cagagactgg accttagaag atagctctca agaactttgg     2160



aaataatttt atatatatat aaataatata tatatatata catatatata aatagatctc     2220



tatatagttg tggtacggtc taaaagcagt cttgtttcct ggaaataaaa agttgggata     2280



ttaacttgtt tttgcacttt agaatagcat gagaatctca ctaatttagc attctgataa     2340



aagaaacttt agagcaagtc agaatagaga ggtgtttttc ctttgagggg ataggggaag     2400



taagccaata agaacctttt aaacaaatcg tcctgtcaca aaatgctttc atatggctta     2460



attttgtcaa cactgcattg tcttttgagc tcttttttcc cccccaacaa agtttttttg     2520



ttttttgttt ttttttttaa gtagaaattc cctccagttt tattagcctc tttatatgtc     2580



tcaaattgca tgaatttttt ctggctgttg gaaacctgaa tgcttttaga cccaaatgga     2640



aaatttctga aatgctggat tatctatttt taaacaagca gttgacttaa aactttctgt     2700



ggcaacttct ggttttctga cagttcccag tgagagaaat gctgaaagta cactgggatc     2760



actgggacac tgtcttatga aggtttgctt gggatgaaaa aggatattgc agcttcagca     2820



gtgttgaact gtgtgtttaa aaatgtgaat tactgttatt gtatactgta attgattaca     2880



tgggctgggg gggtgtcaaa gaacttgaca ggttgtgttg atgctcttag ttgagtcttg     2940



aaaagtaaat attaacgcta cagaaatgca tgagtttcaa tatatttttt gtctttgttt     3000



gcattgtata actttaacga gtgagtttaa aattatttaa tttccttaga aaaatagcac     3060



catttggaaa aaaaaactgg tgttatgaag aacgtaaatg cactgttttt atttttattt     3120



tatataattt aaattgactt tcccactgtc tttaagttga aactgttaag ctgaataaaa     3180



acttaagctg caaattgata acttcgctac ataacaagga aaatataaat gtttacaaac     3240



agcttaaaga tttgcatgtg cagtgtgcat ttataacaaa cttctaattg cacaaaaccc     3300



atgccagctc agagtttagg tgtacacatt tacccagttg agcgttctta gaataactac     3360



tgcacaagtt gacaataggt cgttctctct ttttttttgt ttgctccctt tttctttttc     3420



tccccttcct ccttaccctc cctcccttac tctccccccc caccaccacc ctccaccccc     3480



aactcatgaa aagattctat ggactgaaaa agccccaggc tgaaaggact ggactgcctt     3540



gattgacatg gggaaggggg ttagtagact atgtggattg cggcagcaga ggctgcagcc     3600



taacgtgtgg ttttaatgac cagcacgcaa ggcaaaagca ttttgcacag tgtttgtttt     3660



cctgtcttgc acttacaaat aaggtctatg ggagtagcat ggaaaacgtt tgctgttttt     3720



cccttttttt tttaattgct tttgtttaaa atttgatcgc cttaactact gtaaacatag     3780



cctatttttg tgcttaagat actgaatgga aaactccatt gtgtgttgct ggactgtttt     3840



ggaaatattt ggttaaatgt gtgttaattt ggctgtaatg gcatttaaag caaacaaaca     3900



aacaaaaaaa gctgtgaaaa tggccttgga gcattatctt tagttacttg aagagtttct     3960



agttttttta aaatacagtt tatgttaaaa taatttttat taatttagag aagacaatca     4020



atgtctgtga gaaaacggac tttcttttgg attttctttt tgtggtcatt gtgagtgatt     4080



gctttttcct tttcttagtt tcacattctt cctttgttct aaaacttaga ctgacatcta     4140



gctttgacaa tcatagtatg ttttattttc ctgaggggga ataacttata atgctgttta     4200



gttttgtact attggtgtgt tggtgaattt ttaaactgtg tgctaactgc aataaattat     4260



atgaactgag aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa      4319





<210>  54

<211>  522

<212>  PRT

<213>  Homo sapiens



<400>  54



Met Glu Phe Pro Asp His Ser Arg His Leu Leu Gln Cys Leu Ser Glu 

1               5                   10                  15      





Gln Arg His Gln Gly Phe Leu Cys Asp Cys Thr Val Leu Val Gly Asp 

            20                  25                  30          





Ala Gln Phe Arg Ala His Arg Ala Val Leu Ala Ser Cys Ser Met Tyr 

        35                  40                  45              





Phe His Leu Phe Tyr Lys Asp Gln Leu Asp Lys Arg Asp Ile Val His 

    50                  55                  60                  





Leu Asn Ser Asp Ile Val Thr Ala Pro Ala Phe Ala Leu Leu Leu Glu 

65                  70                  75                  80  





Phe Met Tyr Glu Gly Lys Leu Gln Phe Lys Asp Leu Pro Ile Glu Asp 

                85                  90                  95      





Val Leu Ala Ala Ala Ser Tyr Leu His Met Tyr Asp Ile Val Lys Val 

            100                 105                 110         





Cys Lys Lys Lys Leu Lys Glu Lys Ala Thr Thr Glu Ala Asp Ser Thr 

        115                 120                 125             





Lys Lys Glu Glu Asp Ala Ser Ser Cys Ser Asp Lys Val Glu Ser Leu 

    130                 135                 140                 





Ser Asp Gly Ser Ser His Ile Ala Gly Asp Leu Pro Ser Asp Glu Asp 

145                 150                 155                 160 





Glu Gly Glu Asp Glu Lys Leu Asn Ile Leu Pro Ser Lys Arg Asp Leu 

                165                 170                 175     





Ala Ala Glu Pro Gly Asn Met Trp Met Arg Leu Pro Ser Asp Ser Ala 

            180                 185                 190         





Gly Ile Pro Gln Ala Gly Gly Glu Ala Glu Pro His Ala Thr Ala Ala 

        195                 200                 205             





Gly Lys Thr Val Ala Ser Pro Cys Ser Ser Thr Glu Ser Leu Ser Gln 

    210                 215                 220                 





Arg Ser Val Thr Ser Val Arg Asp Ser Ala Asp Val Asp Cys Val Leu 

225                 230                 235                 240 





Asp Leu Ser Val Lys Ser Ser Leu Ser Gly Val Glu Asn Leu Asn Ser 

                245                 250                 255     





Ser Tyr Phe Ser Ser Gln Asp Val Leu Arg Ser Asn Leu Val Gln Val 

            260                 265                 270         





Lys Val Glu Lys Glu Ala Ser Cys Asp Glu Ser Asp Val Gly Thr Asn 

        275                 280                 285             





Asp Tyr Asp Met Glu His Ser Thr Val Lys Glu Ser Val Ser Thr Asn 

    290                 295                 300                 





Asn Arg Val Gln Tyr Glu Pro Ala His Leu Ala Pro Leu Arg Glu Asp 

305                 310                 315                 320 





Ser Val Leu Arg Glu Leu Asp Arg Glu Asp Lys Ala Ser Asp Asp Glu 

                325                 330                 335     





Met Met Thr Pro Glu Ser Glu Arg Val Gln Val Glu Gly Gly Met Glu 

            340                 345                 350         





Ser Ser Leu Leu Pro Tyr Val Ser Asn Ile Leu Ser Pro Ala Gly Gln 

        355                 360                 365             





Ile Phe Met Cys Pro Leu Cys Asn Lys Val Phe Pro Ser Pro His Ile 

    370                 375                 380                 





Leu Gln Ile His Leu Ser Thr His Phe Arg Glu Gln Asp Gly Ile Arg 

385                 390                 395                 400 





Ser Lys Pro Ala Ala Asp Val Asn Val Pro Thr Cys Ser Leu Cys Gly 

                405                 410                 415     





Lys Thr Phe Ser Cys Met Tyr Thr Leu Lys Arg His Glu Arg Thr His 

            420                 425                 430         





Ser Gly Glu Lys Pro Tyr Thr Cys Thr Gln Cys Gly Lys Ser Phe Gln 

        435                 440                 445             





Tyr Ser His Asn Leu Ser Arg His Ala Val Val His Thr Arg Glu Lys 

    450                 455                 460                 





Pro His Ala Cys Lys Trp Cys Glu Arg Arg Phe Thr Gln Ser Gly Asp 

465                 470                 475                 480 





Leu Tyr Arg His Ile Arg Lys Phe His Cys Glu Leu Val Asn Ser Leu 

                485                 490                 495     





Ser Val Lys Ser Glu Ala Leu Ser Leu Pro Thr Val Arg Asp Trp Thr 

            500                 505                 510         





Leu Glu Asp Ser Ser Gln Glu Leu Trp Lys 

        515                 520         





<210>  55

<211>  4030

<212>  DNA

<213>  Homo sapiens



<400>  55

acccggcccg gcggctccgc gctcgctccc tcgctcgctc cctcgctgtg tctggcaggc       60



tgcggccgcc gctgggctgc tgccatgggg agccgttgag agtggggccc tcttcgctcc      120



gccgcgctcc tccggctgcc agcgggggtg ggcgggaggg aggggcgggg gggagcgggc      180



gacggagccg ggattggggg gtgggggggc cgggagggag gggggcaaga gccggaggaa      240



gcccaccaag tccggcggcg gcggcggcgg ccgggaggag gaggaggagg aggcggagga      300



cgcggcggcg gcggggacgc ggtgacttag ggccgctccg tgttatgaag acagtatgga      360



gtttccagac catagtagac atttgctaca gtgtctgagc gagcagagac accagggttt      420



tctttgtgac tgcactgttc tggtgggaga tgcccagttc cgagcgcacc gagctgtact      480



ggcttcatgc agcatgtatt tccacctctt ttacaaggac cagctggaca aaagagacat      540



tgttcatctg aacagcgaca ttgttacagc ccccgctttc gctctcctgc ttgaattcat      600



gtatgaaggg aaactccagt tcaaagactt gcccattgaa gacgtgctag cagctgccag      660



ttatctccac atgtatgaca ttgtcaaagt ctgcaaaaag aagctgaaag agaaagccac      720



cacggaggca gacagcacca aaaaggaaga agatgcttca agttgttcgg acaaagtcga      780



gagtctctcc gatggcagca gccacatagc aggcgatttg cccagtgatg aagatgaagg      840



agaagatgaa aaattgaaca tcctgcccag caaaagggac ttggcggccg agcctgggaa      900



catgtggatg cgattgccct cagactcagc aggcatcccc caggctggcg gagaggcaga      960



gccacacgcc acagcagctg gaaaaacagt agccagcccc tgcagctcaa cagagtcttt     1020



gtcccagagg tctgtcacct ccgtgaggga ttcggcagat gttgactgtg tgctggacct     1080



gtctgtcaag tccagccttt caggagttga aaatctgaac agctcttatt tctcttcaca     1140



ggacgtgctg agaagcaacc tggtgcaggt gaaggtggag aaagaggctt cctgtgatga     1200



gagtgatgtt ggcactaatg actatgacat ggaacatagc actgtgaaag aaagtgtgag     1260



cactaataac agggtacagt atgagccggc ccatctggct cccctgaggg aggactcggt     1320



cttgagggag ctggaccggg aggacaaagc cagtgatgat gagatgatga ccccagagag     1380



cgagcgtgtc caggtggagg gaggcatgga gagcagtctg ctcccctacg tctccaacat     1440



cctgagcccc gcgggccaga tcttcatgtg ccccctgtgc aacaaggtct tccccagccc     1500



ccacatcctg cagatccacc tgagcacgca cttccgcgag caggacggca tccgcagcaa     1560



gcccgccgcc gatgtcaacg tgcccacgtg ctcgctgtgt gggaagactt tctcttgcat     1620



gtacaccctc aagcgccacg agaggactca ctcgggggag aagccctaca catgcaccca     1680



gtgcggcaag agcttccagt actcgcacaa cctgagccgc catgccgtgg tgcacacccg     1740



cgagaagccg cacgcctgca agtggtgcga gcgcaggttc acgcagtccg gggacctgta     1800



cagacacatt cgcaagttcc actgtgagtt ggtgaactcc ttgtcggtca aaagcgaagc     1860



actgagcttg cctactgtca gagactggac cttagaagat agctctcaag aactttggaa     1920



ataattttat atatatataa ataatatata tatatataca tatatataaa tagatctcta     1980



tatagttgtg gtacggtcta aaagcagtct tgtttcctgg aaataaaaag ttgggatatt     2040



aacttgtttt tgcactttag aatagcatga gaatctcact aatttagcat tctgataaaa     2100



gaaactttag agcaagtcag aatagagagg tgtttttcct ttgaggggat aggggaagta     2160



agccaataag aaccttttaa acaaatcgtc ctgtcacaaa atgctttcat atggcttaat     2220



tttgtcaaca ctgcattgtc ttttgagctc ttttttcccc cccaacaaag tttttttgtt     2280



ttttgttttt ttttttaagt agaaattccc tccagtttta ttagcctctt tatatgtctc     2340



aaattgcatg aattttttct ggctgttgga aacctgaatg cttttagacc caaatggaaa     2400



atttctgaaa tgctggatta tctattttta aacaagcagt tgacttaaaa ctttctgtgg     2460



caacttctgg ttttctgaca gttcccagtg agagaaatgc tgaaagtaca ctgggatcac     2520



tgggacactg tcttatgaag gtttgcttgg gatgaaaaag gatattgcag cttcagcagt     2580



gttgaactgt gtgtttaaaa atgtgaatta ctgttattgt atactgtaat tgattacatg     2640



ggctgggggg gtgtcaaaga acttgacagg ttgtgttgat gctcttagtt gagtcttgaa     2700



aagtaaatat taacgctaca gaaatgcatg agtttcaata tattttttgt ctttgtttgc     2760



attgtataac tttaacgagt gagtttaaaa ttatttaatt tccttagaaa aataacacca     2820



tttggaaaaa aaaactggtg ttatgaagaa cgtaaatgca ctgtttttat ttttatttta     2880



tataatttaa attgactttc ccactgtctt taagttgaaa ctgttaagct gaataaaaac     2940



ttaagctgca aattgataac ttcgctacat aacaaggaaa atataaatgt ttacaaacag     3000



cttaaagatt tgcatgtgca gtgtgcattt ataacaaact tctaattgca caaaacccat     3060



gccagctcag agtttaggtg tacacattta cccagttgag cgttcttaga ataactactg     3120



cacaagttga caataggtcg ttctctcttt ttttttgttt gctccctttt tctttttctc     3180



cccttcctcc ttaccctccc tcccttactc tcccccccca ccaccaccct ccacccccaa     3240



ctcatgaaaa gattctatgg actgaaaaag ccccaggctg aaaggactgg actgccttga     3300



ttgacatggg gaagggggtt agtagactat gtggattgcg gcagcagagg ctgcagccta     3360



acgtgtggtt ttaatgacca gcacgcaagg caaaagcatt ttgcacagtg tttgttttcc     3420



tgtcttgcac ttacaaataa ggtctatggg agtagcatgg aaaacgtttg ctgtttttcc     3480



cttttttttt taattgcttt tgtttaaaat ttgatcgcct taactactgt aaacatagcc     3540



tatttttgtg cttaagatac tgaatggaaa actccattgt gtgttgctgg actgttttgg     3600



aaatatttgg ttaaatgtgt gttaatttgg ctgtaatggc atttaaagca aacaaacaaa     3660



caaaaaaagc tgtgaaaatg gccttggagc attatcttta gttacttgaa gagtttctag     3720



tttttttaaa atacagttta tgttaaaata atttttatta atttagagaa gacaatcaat     3780



gtctgtgaga aaacggactt tcttttggat tttctttttg tggtcattgt gagtgattgc     3840



tttttccttt tcttagtttc acattcttcc tttgttctaa aacttagact gacatctagc     3900



tttgacaatc atagtatgtt ttattttcct gagggggaat aacttataat gctgtttagt     3960



tttgtactat tggtgtgttg gtgaattttt aaactgtgtg ctaactgcaa taaattatat     4020



gaactgagaa                                                            4030





