                         б

<110>  ϺҽҩƼ޹˾ż޹˾

<120>  Ѫ׵׵Ŀԭϵ

<130>  0134-PA-038 

<160>  38

<170>  PatentIn version 3.5

<210>  1
<211>  15
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab0716.1Ab0716.4Ab0716.Hz1Ab0716.Hz2Ab0716Am01m02m06 HCDR3

<400>  1

Ser Thr Arg Ile Thr Leu Ile Ser Asp Gln Tyr Gly Tyr Arg Asp 
1               5                   10                  15  


<210>  2
<211>  6
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  AbAb0716Am01 HCDR2

<400>  2

Thr Trp Ser Gly Asp Asp 
1               5       


<210>  3
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  AbAb0716Am02m06 HCDR1

<400>  3

Gly His Thr Phe Ser Arg Tyr 
1               5           


<210>  4
<211>  25
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab0716.1 H-FR1

<400>  4

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Glu Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  5
<211>  19
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab0716.1Ab0716.2 H-FR2

<400>  5

Gln Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
1               5                   10                  15      


Ala Ser Ile 
            


<210>  6
<211>  41
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab0716.1Ab0716.2Ab0716.4 H-FR3

<400>  6

Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
1               5                   10                  15      


Asn Arg Lys Lys Thr Leu Ser Leu Asp Met Asn Asp Leu Lys Pro Glu 
            20                  25                  30          


Asp Thr Ala Val Tyr Tyr Cys Ala Ala 
        35                  40      


<210>  7
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab0716.1Ab0716.2Ab0716.4 H-FR4

<400>  7

Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  8
<211>  25
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab0716.2 H-FR1

<400>  8

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Glu Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  9
<211>  25
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab0716.4 H-FR1

<400>  9

Ala Val Gln Leu Val Asp Ser Gly Gly Gly Leu Val Glu Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  10
<211>  19
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab0716.4 H-FR2

<400>  10

Gln Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
1               5                   10                  15      


Ala Ser Thr 
            


<210>  11
<211>  25
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab0716.Hz1Ab0716.Hz2 H-FR1

<400>  11

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  12
<211>  19
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab0716.Hz1 H-FR2

<400>  12

Gln Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 
1               5                   10                  15      


Ser Ser Ile 
            


<210>  13
<211>  41
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab0716.Hz1Ab0716.Hz2 H-FR3

<400>  13

Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
1               5                   10                  15      


Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
            20                  25                  30          


Asp Thr Ala Val Tyr Tyr Cys Ala Ala 
        35                  40      


<210>  14
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab0716.Hz1 H-FR4

<400>  14

Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
1               5                   10      


<210>  15
<211>  19
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab0716.Hz2 H-FR2

<400>  15

Gln Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val 
1               5                   10                  15      


Ser Ser Ile 
            


<210>  16
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab0716.Hz2 H-FR4

<400>  16

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  17
<211>  124
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab0716.1 VH

<400>  17

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Glu Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly His Thr Phe Ser Arg Tyr 
            20                  25                  30          


Gln Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ser Ile Thr Trp Ser Gly Asp Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Arg Lys Lys Thr Leu Ser 
65                  70                  75                  80  


Leu Asp Met Asn Asp Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ser Thr Arg Ile Thr Leu Ile Ser Asp Gln Tyr Gly Tyr Arg 
            100                 105                 110         


Asp Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  18
<211>  124
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab0716.2 VH

<400>  18

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Glu Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly His Thr Phe Ser Arg Tyr 
            20                  25                  30          


Gln Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ser Ile Thr Trp Ser Gly Asp Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Arg Lys Lys Thr Leu Ser 
65                  70                  75                  80  


Leu Asp Met Asn Asp Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ser Thr Arg Ile Thr Leu Ile Ser Asp Gln His Gly Tyr Arg 
            100                 105                 110         


Asp Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  19
<211>  124
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab0716.4 VH

<400>  19

Ala Val Gln Leu Val Asp Ser Gly Gly Gly Leu Val Glu Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly His Thr Phe Ser Arg Tyr 
            20                  25                  30          


Gln Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ser Thr Thr Trp Ser Gly Asp Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Arg Lys Lys Thr Leu Ser 
65                  70                  75                  80  


Leu Asp Met Asn Asp Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ser Thr Arg Ile Thr Leu Ile Ser Asp Gln Tyr Gly Tyr Arg 
            100                 105                 110         


Asp Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  20
<211>  124
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab0716.Hz1 VH

<400>  20

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly His Thr Phe Ser Arg Tyr 
            20                  25                  30          


Gln Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 
        35                  40                  45              


Ser Ser Ile Thr Trp Ser Gly Asp Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ser Thr Arg Ile Thr Leu Ile Ser Asp Gln Tyr Gly Tyr Arg 
            100                 105                 110         


Asp Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 


<210>  21
<211>  124
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab0716.Hz2 VH

<400>  21

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly His Thr Phe Ser Arg Tyr 
            20                  25                  30          


Gln Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val 
        35                  40                  45              


Ser Ser Ile Thr Trp Ser Gly Asp Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ser Thr Arg Ile Thr Leu Ile Ser Asp Gln Tyr Gly Tyr Arg 
            100                 105                 110         


Asp Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  22
<211>  25
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  H-FR1ͨʽ

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa = AlaAspGlu

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa = AspGlu

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa = GluGln

<400>  22

Xaa Val Gln Leu Val Xaa Ser Gly Gly Gly Leu Val Xaa Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  23
<211>  19
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  H-FR2ͨʽ

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa = GluGly

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa = LeuArg

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa = AlaSer

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  Xaa = IleThr

<400>  23

Gln Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Xaa Xaa Glu Phe Val 
1               5                   10                  15      


Xaa Ser Xaa 
            


<210>  24
<211>  41
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  H-FR3ͨʽ

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa = ArgSer

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Xaa = LysAsn

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  Xaa = SerTyr

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  Xaa = AspGln

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  Xaa = AspSer

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  Xaa = LysArg

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  Xaa = AlaPro

<400>  24

Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
1               5                   10                  15      


Asn Xaa Lys Xaa Thr Leu Xaa Leu Xaa Met Asn Xaa Leu Xaa Xaa Glu 
            20                  25                  30          


Asp Thr Ala Val Tyr Tyr Cys Ala Ala 
        35                  40      


<210>  25
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  H-FR4ͨʽ

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa = LeuMetGln

<400>  25

Trp Gly Gln Gly Thr Xaa Val Thr Val Ser Ser 
1               5                   10      


<210>  26
<211>  124
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VHͨʽ

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa = AlaAspGlu

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa = AspGlu

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa = GluGln

<220>
<221>  misc_feature
<222>  (44)..(44)
<223>  Xaa = GluGly

<220>
<221>  misc_feature
<222>  (45)..(45)
<223>  Xaa = LeuArg

<220>
<221>  misc_feature
<222>  (49)..(49)
<223>  Xaa = AlaSer

<220>
<221>  misc_feature
<222>  (51)..(51)
<223>  Xaa = IleThr

<220>
<221>  misc_feature
<222>  (75)..(75)
<223>  Xaa = ArgSer

<220>
<221>  misc_feature
<222>  (77)..(77)
<223>  Xaa = LysAsn

<220>
<221>  misc_feature
<222>  (80)..(80)
<223>  Xaa = SerTyr

<220>
<221>  misc_feature
<222>  (82)..(82)
<223>  Xaa = AspGln

<220>
<221>  misc_feature
<222>  (85)..(85)
<223>  Xaa = AspSer

<220>
<221>  misc_feature
<222>  (87)..(87)
<223>  Xaa = LysArg

<220>
<221>  misc_feature
<222>  (88)..(88)
<223>  Xaa = AlaPro

<220>
<221>  misc_feature
<222>  (109)..(109)
<223>  Xaa = HisTyr

<220>
<221>  misc_feature
<222>  (119)..(119)
<223>  Xaa = LeuMetGln

<400>  26

Xaa Val Gln Leu Val Xaa Ser Gly Gly Gly Leu Val Xaa Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly His Thr Phe Ser Arg Tyr 
            20                  25                  30          


Gln Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Xaa Xaa Glu Phe Val 
        35                  40                  45              


Xaa Ser Xaa Thr Trp Ser Gly Asp Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Xaa Lys Xaa Thr Leu Xaa 
65                  70                  75                  80  


Leu Xaa Met Asn Xaa Leu Xaa Xaa Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ser Thr Arg Ile Thr Leu Ile Ser Asp Gln Xaa Gly Tyr Arg 
            100                 105                 110         


Asp Trp Gly Gln Gly Thr Xaa Val Thr Val Ser Ser 
        115                 120                 


<210>  27
<211>  115
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  ԶտVHH

<400>  27

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  28
<211>  15
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab0716.2 HCDR3

<400>  28

Ser Thr Arg Ile Thr Leu Ile Ser Asp Gln His Gly Tyr Arg Asp 
1               5                   10                  15  


<210>  29
<211>  15
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR3ͨʽ

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa = HisTyr

<400>  29

Ser Thr Arg Ile Thr Leu Ile Ser Asp Gln Xaa Gly Tyr Arg Asp 
1               5                   10                  15  


<210>  30
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab0716Am01 HCDR1

<400>  30

Gly Trp Thr Phe Ser Arg Tyr 
1               5           


<210>  31
<211>  6
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab0716Am02 HCDR2

<400>  31

Ser Trp Ser Gly Arg Ala 
1               5       


<210>  32
<211>  6
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab0716Am06 HCDR2

<400>  32

Asp Trp Ser Asn Thr Ile 
1               5       


<210>  33
<211>  124
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab0716Am01 VH

<400>  33

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Trp Thr Phe Ser Arg Tyr 
            20                  25                  30          


Gln Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val 
        35                  40                  45              


Ser Ser Ile Thr Trp Ser Gly Asp Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ser Thr Arg Ile Thr Leu Ile Ser Asp Gln Tyr Gly Tyr Arg 
            100                 105                 110         


Asp Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  34
<211>  124
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab0716Am02 VH

<400>  34

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly His Thr Phe Ser Arg Tyr 
            20                  25                  30          


Gln Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val 
        35                  40                  45              


Ser Ser Ile Ser Trp Ser Gly Arg Ala Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ser Thr Arg Ile Thr Leu Ile Ser Asp Gln Tyr Gly Tyr Arg 
            100                 105                 110         


Asp Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  35
<211>  124
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab0716Am06 VH

<400>  35

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly His Thr Phe Ser Arg Tyr 
            20                  25                  30          


Gln Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val 
        35                  40                  45              


Ser Ser Ile Asp Trp Ser Asn Thr Ile Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ser Thr Arg Ile Thr Leu Ile Ser Asp Gln Tyr Gly Tyr Arg 
            100                 105                 110         


Asp Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  36
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR1ͨʽ

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa = HisTrp

<400>  36

Gly Xaa Thr Phe Ser Arg Tyr 
1               5           


<210>  37
<211>  6
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR2ͨʽ

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa = AspSerThr

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa = GlyAsn

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa = AspArgThr

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa = AlaAspIle

<400>  37

Xaa Trp Ser Xaa Xaa Xaa 
1               5       


<210>  38
<211>  124
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VHͨʽ 2

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa = AlaAspGlu

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa = AspGlu

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa = GluGln

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  Xaa = HisTrp

<220>
<221>  misc_feature
<222>  (44)..(44)
<223>  Xaa = GluGly

<220>
<221>  misc_feature
<222>  (45)..(45)
<223>  Xaa = LeuArg

<220>
<221>  misc_feature
<222>  (49)..(49)
<223>  Xaa = AlaSer

<220>
<221>  misc_feature
<222>  (51)..(51)
<223>  Xaa = IleThr

<220>
<221>  misc_feature
<222>  (52)..(52)
<223>  Xaa = AspSerThr

<220>
<221>  misc_feature
<222>  (55)..(55)
<223>  Xaa = GlyAsn

<220>
<221>  misc_feature
<222>  (56)..(56)
<223>  Xaa = AspArgThr

<220>
<221>  misc_feature
<222>  (57)..(57)
<223>  Xaa = AlaAspIle

<220>
<221>  misc_feature
<222>  (75)..(75)
<223>  Xaa = ArgSer

<220>
<221>  misc_feature
<222>  (77)..(77)
<223>  Xaa = LysAsn

<220>
<221>  misc_feature
<222>  (80)..(80)
<223>  Xaa = SerTyr

<220>
<221>  misc_feature
<222>  (82)..(82)
<223>  Xaa = AspGln

<220>
<221>  misc_feature
<222>  (85)..(85)
<223>  Xaa = AspSer

<220>
<221>  misc_feature
<222>  (87)..(87)
<223>  Xaa = LysArg

<220>
<221>  misc_feature
<222>  (88)..(88)
<223>  Xaa = AlaPro

<220>
<221>  misc_feature
<222>  (109)..(109)
<223>  Xaa = HisTyr

<220>
<221>  misc_feature
<222>  (119)..(119)
<223>  Xaa = LeuMetGln

<400>  38

Xaa Val Gln Leu Val Xaa Ser Gly Gly Gly Leu Val Xaa Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Xaa Thr Phe Ser Arg Tyr 
            20                  25                  30          


Gln Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Xaa Xaa Glu Phe Val 
        35                  40                  45              


Xaa Ser Xaa Xaa Trp Ser Xaa Xaa Xaa Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Xaa Lys Xaa Thr Leu Xaa 
65                  70                  75                  80  


Leu Xaa Met Asn Xaa Leu Xaa Xaa Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ser Thr Arg Ile Thr Leu Ile Ser Asp Gln Xaa Gly Tyr Arg 
            100                 105                 110         


Asp Trp Gly Gln Gly Thr Xaa Val Thr Val Ser Ser 
        115                 120                 
