               SEQUENCE LISTING

<110> OGD2 PHARMA
      UNIVERSITE DE LILLE
      CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

<120> USE OF CASD1 AS A BIOMARKER OF A CANCER EXPRESSING THE OACETYLATED-GD2 GANGLIOSIDE

<130> IBIO-2032/PCT

<150> EP21305797.9
<151> 2021-06-10

<160> 55

<170> BiSSAP 1.3.6

<210> 1
<211> 797
<212> PRT
<213> Homo sapiens


<220> 
<223> CASD1 human protein

<400> 1
Met Ala Ala Leu Ala Tyr Asn Leu Gly Lys Arg Glu Ile Asn His Tyr 
1               5                   10                  15      
Phe Ser Val Arg Ser Ala Lys Val Leu Ala Leu Val Ala Val Leu Leu 
            20                  25                  30          
Leu Ala Ala Cys His Leu Ala Ser Arg Arg Tyr Arg Gly Asn Asp Ser 
        35                  40                  45              
Cys Glu Tyr Leu Leu Ser Ser Gly Arg Phe Leu Gly Glu Lys Val Trp 
    50                  55                  60                  
Gln Pro His Ser Cys Met Met His Lys Tyr Lys Ile Ser Glu Ala Lys 
65                  70                  75                  80  
Asn Cys Leu Val Asp Lys His Ile Ala Phe Ile Gly Asp Ser Arg Ile 
                85                  90                  95      
Arg Gln Leu Phe Tyr Ser Phe Val Lys Ile Ile Asn Pro Gln Phe Lys 
            100                 105                 110         
Glu Glu Gly Asn Lys His Glu Asn Ile Pro Phe Glu Asp Lys Thr Ala 
        115                 120                 125             
Ser Val Lys Val Asp Phe Leu Trp His Pro Glu Val Asn Gly Ser Met 
    130                 135                 140                 
Lys Gln Cys Ile Lys Val Trp Thr Glu Asp Ser Ile Ala Lys Pro His 
145                 150                 155                 160 
Val Ile Val Ala Gly Ala Ala Thr Trp Ser Ile Lys Ile His Asn Gly 
                165                 170                 175     
Ser Ser Glu Ala Leu Ser Gln Tyr Lys Met Asn Ile Thr Ser Ile Ala 
            180                 185                 190         
Pro Leu Leu Glu Lys Leu Ala Lys Thr Ser Asp Val Tyr Trp Val Leu 
        195                 200                 205             
Gln Asp Pro Val Tyr Glu Asp Leu Leu Ser Glu Asn Arg Lys Met Ile 
    210                 215                 220                 
Thr Asn Glu Lys Ile Asp Ala Tyr Asn Glu Ala Ala Val Ser Ile Leu 
225                 230                 235                 240 
Asn Ser Ser Thr Arg Asn Ser Lys Ser Asn Val Lys Met Phe Ser Val 
                245                 250                 255     
Ser Lys Leu Ile Ala Gln Glu Thr Ile Met Glu Ser Leu Asp Gly Leu 
            260                 265                 270         
His Leu Pro Glu Ser Ser Arg Glu Thr Thr Ala Met Ile Leu Met Asn 
        275                 280                 285             
Val Tyr Cys Asn Lys Ile Leu Lys Pro Val Asp Gly Ser Cys Cys Gln 
    290                 295                 300                 
Pro Arg Pro Pro Val Thr Leu Ile Gln Lys Leu Ala Ala Cys Phe Phe 
305                 310                 315                 320 
Thr Leu Ser Ile Ile Gly Tyr Leu Ile Phe Tyr Ile Ile His Arg Asn 
                325                 330                 335     
Ala His Arg Lys Asn Lys Pro Cys Thr Asp Leu Glu Ser Gly Glu Glu 
            340                 345                 350         
Lys Lys Asn Ile Ile Asn Thr Pro Val Ser Ser Leu Glu Ile Leu Leu 
        355                 360                 365             
Gln Ser Phe Cys Lys Leu Gly Leu Ile Met Ala Tyr Phe Tyr Met Cys 
    370                 375                 380                 
Asp Arg Ala Asn Leu Phe Met Lys Glu Asn Lys Phe Tyr Thr His Ser 
385                 390                 395                 400 
Ser Phe Phe Ile Pro Ile Ile Tyr Ile Leu Val Leu Gly Val Phe Tyr 
                405                 410                 415     
Asn Glu Asn Thr Lys Glu Thr Lys Val Leu Asn Arg Glu Gln Thr Asp 
            420                 425                 430         
Glu Trp Lys Gly Trp Met Gln Leu Val Ile Leu Ile Tyr His Ile Ser 
        435                 440                 445             
Gly Ala Ser Thr Phe Leu Pro Val Tyr Met His Ile Arg Val Leu Val 
    450                 455                 460                 
Ala Ala Tyr Leu Phe Gln Thr Gly Tyr Gly His Phe Ser Tyr Phe Trp 
465                 470                 475                 480 
Ile Lys Gly Asp Phe Gly Ile Tyr Arg Val Cys Gln Val Leu Phe Arg 
                485                 490                 495     
Leu Asn Phe Leu Val Val Val Leu Cys Ile Val Met Asp Arg Pro Tyr 
            500                 505                 510         
Gln Phe Tyr Tyr Phe Val Pro Leu Val Thr Val Trp Phe Met Val Ile 
        515                 520                 525             
Tyr Val Thr Leu Ala Leu Trp Pro Gln Ile Ile Gln Lys Lys Ala Asn 
    530                 535                 540                 
Gly Asn Cys Phe Trp His Phe Gly Leu Leu Leu Lys Leu Gly Phe Leu 
545                 550                 555                 560 
Leu Leu Phe Ile Cys Phe Leu Ala Tyr Ser Gln Gly Ala Phe Glu Lys 
                565                 570                 575     
Ile Phe Ser Leu Trp Pro Leu Ser Lys Cys Phe Glu Leu Lys Gly Asn 
            580                 585                 590         
Val Tyr Glu Trp Trp Phe Arg Trp Arg Leu Asp Arg Tyr Val Val Phe 
        595                 600                 605             
His Gly Met Leu Phe Ala Phe Ile Tyr Leu Ala Leu Gln Lys Arg Gln 
    610                 615                 620                 
Ile Leu Ser Glu Gly Lys Gly Glu Pro Leu Phe Ser Asn Lys Ile Ser 
625                 630                 635                 640 
Asn Phe Leu Leu Phe Ile Ser Val Val Ser Phe Leu Thr Tyr Ser Ile 
                645                 650                 655     
Trp Ala Ser Ser Cys Lys Asn Lys Ala Glu Cys Asn Glu Leu His Pro 
            660                 665                 670         
Ser Val Ser Val Val Gln Ile Leu Ala Phe Ile Leu Ile Arg Asn Ile 
        675                 680                 685             
Pro Gly Tyr Ala Arg Ser Val Tyr Ser Ser Phe Phe Ala Trp Phe Gly 
    690                 695                 700                 
Lys Ile Ser Leu Glu Leu Phe Ile Cys Gln Tyr His Ile Trp Leu Ala 
705                 710                 715                 720 
Ala Asp Thr Arg Gly Ile Leu Val Leu Ile Pro Gly Asn Pro Met Leu 
                725                 730                 735     
Asn Ile Ile Val Ser Thr Phe Ile Phe Val Cys Val Ala His Glu Ile 
            740                 745                 750         
Ser Gln Ile Thr Asn Asp Leu Ala Gln Ile Ile Ile Pro Lys Asp Asn 
        755                 760                 765             
Ser Ser Leu Leu Lys Arg Leu Ala Cys Ile Ala Ala Phe Phe Cys Gly 
    770                 775                 780                 
Leu Leu Ile Leu Ser Ser Ile Gln Asp Lys Ser Lys His 
785                 790                 795         

<210> 2
<211> 533
<212> PRT
<213> Homo sapiens


<220> 
<223> GD2 synthase human protein

<400> 2
Met Trp Leu Gly Arg Arg Ala Leu Cys Ala Leu Val Leu Leu Leu Ala 
1               5                   10                  15      
Cys Ala Ser Leu Gly Leu Leu Tyr Ala Ser Thr Arg Asp Ala Pro Gly 
            20                  25                  30          
Leu Arg Leu Pro Leu Ala Pro Trp Ala Pro Pro Gln Ser Pro Arg Arg 
        35                  40                  45              
Pro Glu Leu Pro Asp Leu Ala Pro Glu Pro Arg Tyr Ala His Ile Pro 
    50                  55                  60                  
Val Arg Ile Lys Glu Gln Val Val Gly Leu Leu Ala Trp Asn Asn Cys 
65                  70                  75                  80  
Ser Cys Glu Ser Ser Gly Gly Gly Leu Pro Leu Pro Phe Gln Lys Gln 
                85                  90                  95      
Val Arg Ala Ile Asp Leu Thr Lys Ala Phe Asp Pro Ala Glu Leu Arg 
            100                 105                 110         
Ala Ala Ser Ala Thr Arg Glu Gln Glu Phe Gln Ala Phe Leu Ser Arg 
        115                 120                 125             
Ser Gln Ser Pro Ala Asp Gln Leu Leu Ile Ala Pro Ala Asn Ser Pro 
    130                 135                 140                 
Leu Gln Tyr Pro Leu Gln Gly Val Glu Val Gln Pro Leu Arg Ser Ile 
145                 150                 155                 160 
Leu Val Pro Gly Leu Ser Leu Gln Ala Ala Ser Gly Gln Glu Val Tyr 
                165                 170                 175     
Gln Val Asn Leu Thr Ala Ser Leu Gly Thr Trp Asp Val Ala Gly Glu 
            180                 185                 190         
Val Thr Gly Val Thr Leu Thr Gly Glu Gly Gln Ala Asp Leu Thr Leu 
        195                 200                 205             
Val Ser Pro Gly Leu Asp Gln Leu Asn Arg Gln Leu Gln Leu Val Thr 
    210                 215                 220                 
Tyr Ser Ser Arg Ser Tyr Gln Thr Asn Thr Ala Asp Thr Val Arg Phe 
225                 230                 235                 240 
Ser Thr Glu Gly His Glu Ala Ala Phe Thr Ile Arg Ile Arg His Pro 
                245                 250                 255     
Pro Asn Pro Arg Leu Tyr Pro Pro Gly Ser Leu Pro Gln Gly Ala Gln 
            260                 265                 270         
Tyr Asn Ile Ser Ala Leu Val Thr Ile Ala Thr Lys Thr Phe Leu Arg 
        275                 280                 285             
Tyr Asp Arg Leu Arg Ala Leu Ile Thr Ser Ile Arg Arg Phe Tyr Pro 
    290                 295                 300                 
Thr Val Thr Val Val Ile Ala Asp Asp Ser Asp Lys Pro Glu Arg Val 
305                 310                 315                 320 
Ser Gly Pro Tyr Val Glu His Tyr Leu Met Pro Phe Gly Lys Gly Trp 
                325                 330                 335     
Phe Ala Gly Arg Asn Leu Ala Val Ser Gln Val Thr Thr Lys Tyr Val 
            340                 345                 350         
Leu Trp Val Asp Asp Asp Phe Val Phe Thr Ala Arg Thr Arg Leu Glu 
        355                 360                 365             
Arg Leu Val Asp Val Leu Glu Arg Thr Pro Leu Asp Leu Val Gly Gly 
    370                 375                 380                 
Ala Val Arg Glu Ile Ser Gly Phe Ala Thr Thr Tyr Arg Gln Leu Leu 
385                 390                 395                 400 
Ser Val Glu Pro Gly Ala Pro Gly Leu Gly Asn Cys Leu Arg Gln Arg 
                405                 410                 415     
Arg Gly Phe His His Glu Leu Val Gly Phe Pro Gly Cys Val Val Thr 
            420                 425                 430         
Asp Gly Val Val Asn Phe Phe Leu Ala Arg Thr Asp Lys Val Arg Glu 
        435                 440                 445             
Val Gly Phe Asp Pro Arg Leu Ser Arg Val Ala His Leu Glu Phe Phe 
    450                 455                 460                 
Leu Asp Gly Leu Gly Ser Leu Arg Val Gly Ser Cys Ser Asp Val Val 
465                 470                 475                 480 
Val Asp His Ala Ser Lys Leu Lys Leu Pro Trp Thr Ser Arg Asp Ala 
                485                 490                 495     
Gly Ala Glu Thr Tyr Ala Arg Tyr Arg Tyr Pro Gly Ser Leu Asp Glu 
            500                 505                 510         
Ser Gln Met Ala Lys His Arg Leu Leu Phe Phe Lys His Arg Leu Gln 
        515                 520                 525             
Cys Met Thr Ser Gln 
    530             

<210> 3
<211> 356
<212> PRT
<213> Homo sapiens


<220> 
<223> GD3 synthase human protein

<400> 3
Met Ser Pro Cys Gly Arg Ala Arg Arg Gln Thr Ser Arg Gly Ala Met 
1               5                   10                  15      
Ala Val Leu Ala Trp Lys Phe Pro Arg Thr Arg Leu Pro Met Gly Ala 
            20                  25                  30          
Ser Ala Leu Cys Val Val Val Leu Cys Trp Leu Tyr Ile Phe Pro Val 
        35                  40                  45              
Tyr Arg Leu Pro Asn Glu Lys Glu Ile Val Gln Gly Val Leu Gln Gln 
    50                  55                  60                  
Gly Thr Ala Trp Arg Arg Asn Gln Thr Ala Ala Arg Ala Phe Arg Lys 
65                  70                  75                  80  
Gln Met Glu Asp Cys Cys Asp Pro Ala His Leu Phe Ala Met Thr Lys 
                85                  90                  95      
Met Asn Ser Pro Met Gly Lys Ser Met Trp Tyr Asp Gly Glu Phe Leu 
            100                 105                 110         
Tyr Ser Phe Thr Ile Asp Asn Ser Thr Tyr Ser Leu Phe Pro Gln Ala 
        115                 120                 125             
Thr Pro Phe Gln Leu Pro Leu Lys Lys Cys Ala Val Val Gly Asn Gly 
    130                 135                 140                 
Gly Ile Leu Lys Lys Ser Gly Cys Gly Arg Gln Ile Asp Glu Ala Asn 
145                 150                 155                 160 
Phe Val Met Arg Cys Asn Leu Pro Pro Leu Ser Ser Glu Tyr Thr Lys 
                165                 170                 175     
Asp Val Gly Ser Lys Ser Gln Leu Val Thr Ala Asn Pro Ser Ile Ile 
            180                 185                 190         
Arg Gln Arg Phe Gln Asn Leu Leu Trp Ser Arg Lys Thr Phe Val Asp 
        195                 200                 205             
Asn Met Lys Ile Tyr Asn His Ser Tyr Ile Tyr Met Pro Ala Phe Ser 
    210                 215                 220                 
Met Lys Thr Gly Thr Glu Pro Ser Leu Arg Val Tyr Tyr Thr Leu Ser 
225                 230                 235                 240 
Asp Val Gly Ala Asn Gln Thr Val Leu Phe Ala Asn Pro Asn Phe Leu 
                245                 250                 255     
Arg Ser Ile Gly Lys Phe Trp Lys Ser Arg Gly Ile His Ala Lys Arg 
            260                 265                 270         
Leu Ser Thr Gly Leu Phe Leu Val Ser Ala Ala Leu Gly Leu Cys Glu 
        275                 280                 285             
Glu Val Ala Ile Tyr Gly Phe Trp Pro Phe Ser Val Asn Met His Glu 
    290                 295                 300                 
Gln Pro Ile Ser His His Tyr Tyr Asp Asn Val Leu Pro Phe Ser Gly 
305                 310                 315                 320 
Phe His Ala Met Pro Glu Glu Phe Leu Gln Leu Trp Tyr Leu His Lys 
                325                 330                 335     
Ile Gly Ala Leu Arg Met Gln Leu Asp Pro Cys Glu Asp Thr Ser Leu 
            340                 345                 350         
Gln Pro Thr Ser 
        355     

<210> 4
<211> 537
<212> PRT
<213> Homo sapiens


<220> 
<223> CERK human protein

<400> 4
Met Gly Ala Thr Gly Ala Ala Glu Pro Leu Gln Ser Val Leu Trp Val 
1               5                   10                  15      
Lys Gln Gln Arg Cys Ala Val Ser Leu Glu Pro Ala Arg Ala Leu Leu 
            20                  25                  30          
Arg Trp Trp Arg Ser Pro Gly Pro Gly Ala Gly Ala Pro Gly Ala Asp 
        35                  40                  45              
Ala Cys Ser Val Pro Val Ser Glu Ile Ile Ala Val Glu Glu Thr Asp 
    50                  55                  60                  
Val His Gly Lys His Gln Gly Ser Gly Lys Trp Gln Lys Met Glu Lys 
65                  70                  75                  80  
Pro Tyr Ala Phe Thr Val His Cys Val Lys Arg Ala Arg Arg His Arg 
                85                  90                  95      
Trp Lys Trp Ala Gln Val Thr Phe Trp Cys Pro Glu Glu Gln Leu Cys 
            100                 105                 110         
His Leu Trp Leu Gln Thr Leu Arg Glu Met Leu Glu Lys Leu Thr Ser 
        115                 120                 125             
Arg Pro Lys His Leu Leu Val Phe Ile Asn Pro Phe Gly Gly Lys Gly 
    130                 135                 140                 
Gln Gly Lys Arg Ile Tyr Glu Arg Lys Val Ala Pro Leu Phe Thr Leu 
145                 150                 155                 160 
Ala Ser Ile Thr Thr Asp Ile Ile Val Thr Glu His Ala Asn Gln Ala 
                165                 170                 175     
Lys Glu Thr Leu Tyr Glu Ile Asn Ile Asp Lys Tyr Asp Gly Ile Val 
            180                 185                 190         
Cys Val Gly Gly Asp Gly Met Phe Ser Glu Val Leu His Gly Leu Ile 
        195                 200                 205             
Gly Arg Thr Gln Arg Ser Ala Gly Val Asp Gln Asn His Pro Arg Ala 
    210                 215                 220                 
Val Leu Val Pro Ser Ser Leu Arg Ile Gly Ile Ile Pro Ala Gly Ser 
225                 230                 235                 240 
Thr Asp Cys Val Cys Tyr Ser Thr Val Gly Thr Ser Asp Ala Glu Thr 
                245                 250                 255     
Ser Ala Leu His Ile Val Val Gly Asp Ser Leu Ala Met Asp Val Ser 
            260                 265                 270         
Ser Val His His Asn Ser Thr Leu Leu Arg Tyr Ser Val Ser Leu Leu 
        275                 280                 285             
Gly Tyr Gly Phe Tyr Gly Asp Ile Ile Lys Asp Ser Glu Lys Lys Arg 
    290                 295                 300                 
Trp Leu Gly Leu Ala Arg Tyr Asp Phe Ser Gly Leu Lys Thr Phe Leu 
305                 310                 315                 320 
Ser His His Cys Tyr Glu Gly Thr Val Ser Phe Leu Pro Ala Gln His 
                325                 330                 335     
Thr Val Gly Ser Pro Arg Asp Arg Lys Pro Cys Arg Ala Gly Cys Phe 
            340                 345                 350         
Val Cys Arg Gln Ser Lys Gln Gln Leu Glu Glu Glu Gln Lys Lys Ala 
        355                 360                 365             
Leu Tyr Gly Leu Glu Ala Ala Glu Asp Val Glu Glu Trp Gln Val Val 
    370                 375                 380                 
Cys Gly Lys Phe Leu Ala Ile Asn Ala Thr Asn Met Ser Cys Ala Cys 
385                 390                 395                 400 
Arg Arg Ser Pro Arg Gly Leu Ser Pro Ala Ala His Leu Gly Asp Gly 
                405                 410                 415     
Ser Ser Asp Leu Ile Leu Ile Arg Lys Cys Ser Arg Phe Asn Phe Leu 
            420                 425                 430         
Arg Phe Leu Ile Arg His Thr Asn Gln Gln Asp Gln Phe Asp Phe Thr 
        435                 440                 445             
Phe Val Glu Val Tyr Arg Val Lys Lys Phe Gln Phe Thr Ser Lys His 
    450                 455                 460                 
Met Glu Asp Glu Asp Ser Asp Leu Lys Glu Gly Gly Lys Lys Arg Phe 
465                 470                 475                 480 
Gly His Ile Cys Ser Ser His Pro Ser Cys Cys Cys Thr Val Ser Asn 
                485                 490                 495     
Ser Ser Trp Asn Cys Asp Gly Glu Val Leu His Ser Pro Ala Ile Glu 
            500                 505                 510         
Val Arg Val His Cys Gln Leu Val Arg Leu Phe Ala Arg Gly Ile Glu 
        515                 520                 525             
Glu Asn Pro Lys Pro Asp Ser His Ser 
    530                 535         

<210> 5
<211> 1686
<212> PRT
<213> Homo sapiens


<220> 
<223> PIK3C2A human protein

<400> 5
Met Ala Gln Ile Ser Ser Asn Ser Gly Phe Lys Glu Cys Pro Ser Ser 
1               5                   10                  15      
His Pro Glu Pro Thr Arg Ala Lys Asp Val Asp Lys Glu Glu Ala Leu 
            20                  25                  30          
Gln Met Glu Ala Glu Ala Leu Ala Lys Leu Gln Lys Asp Arg Gln Val 
        35                  40                  45              
Thr Asp Asn Gln Arg Gly Phe Glu Leu Ser Ser Ser Thr Arg Lys Lys 
    50                  55                  60                  
Ala Gln Val Tyr Asn Lys Gln Asp Tyr Asp Leu Met Val Phe Pro Glu 
65                  70                  75                  80  
Ser Asp Ser Gln Lys Arg Ala Leu Asp Ile Asp Val Glu Lys Leu Thr 
                85                  90                  95      
Gln Ala Glu Leu Glu Lys Leu Leu Leu Asp Asp Ser Phe Glu Thr Lys 
            100                 105                 110         
Lys Thr Pro Val Leu Pro Val Thr Pro Ile Leu Ser Pro Ser Phe Ser 
        115                 120                 125             
Ala Gln Leu Tyr Phe Arg Pro Thr Ile Gln Arg Gly Gln Trp Pro Pro 
    130                 135                 140                 
Gly Leu Pro Gly Pro Ser Thr Tyr Ala Leu Pro Ser Ile Tyr Pro Ser 
145                 150                 155                 160 
Thr Tyr Ser Lys Gln Ala Ala Phe Gln Asn Gly Phe Asn Pro Arg Met 
                165                 170                 175     
Pro Thr Phe Pro Ser Thr Glu Pro Ile Tyr Leu Ser Leu Pro Gly Gln 
            180                 185                 190         
Ser Pro Tyr Phe Ser Tyr Pro Leu Thr Pro Ala Thr Pro Phe His Pro 
        195                 200                 205             
Gln Gly Ser Leu Pro Ile Tyr Arg Pro Val Val Ser Thr Asp Met Ala 
    210                 215                 220                 
Lys Leu Phe Asp Lys Ile Ala Ser Thr Ser Glu Phe Leu Lys Asn Gly 
225                 230                 235                 240 
Lys Ala Arg Thr Asp Leu Glu Ile Thr Asp Ser Lys Val Ser Asn Leu 
                245                 250                 255     
Gln Val Ser Pro Lys Ser Glu Asp Ile Ser Lys Phe Asp Trp Leu Asp 
            260                 265                 270         
Leu Asp Pro Leu Ser Lys Pro Lys Val Asp Asn Val Glu Val Leu Asp 
        275                 280                 285             
His Glu Glu Glu Lys Asn Val Ser Ser Leu Leu Ala Lys Asp Pro Trp 
    290                 295                 300                 
Asp Ala Val Leu Leu Glu Glu Arg Ser Thr Ala Asn Cys His Leu Glu 
305                 310                 315                 320 
Arg Lys Val Asn Gly Lys Ser Leu Ser Val Ala Thr Val Thr Arg Ser 
                325                 330                 335     
Gln Ser Leu Asn Ile Arg Thr Thr Gln Leu Ala Lys Ala Gln Gly His 
            340                 345                 350         
Ile Ser Gln Lys Asp Pro Asn Gly Thr Ser Ser Leu Pro Thr Gly Ser 
        355                 360                 365             
Ser Leu Leu Gln Glu Val Glu Val Gln Asn Glu Glu Met Ala Ala Phe 
    370                 375                 380                 
Cys Arg Ser Ile Thr Lys Leu Lys Thr Lys Phe Pro Tyr Thr Asn His 
385                 390                 395                 400 
Arg Thr Asn Pro Gly Tyr Leu Leu Ser Pro Val Thr Ala Gln Arg Asn 
                405                 410                 415     
Ile Cys Gly Glu Asn Ala Ser Val Lys Val Ser Ile Asp Ile Glu Gly 
            420                 425                 430         
Phe Gln Leu Pro Val Thr Phe Thr Cys Asp Val Ser Ser Thr Val Glu 
        435                 440                 445             
Ile Ile Ile Met Gln Ala Leu Cys Trp Val His Asp Asp Leu Asn Gln 
    450                 455                 460                 
Val Asp Val Gly Ser Tyr Val Leu Lys Val Cys Gly Gln Glu Glu Val 
465                 470                 475                 480 
Leu Gln Asn Asn His Cys Leu Gly Ser His Glu His Ile Gln Asn Cys 
                485                 490                 495     
Arg Lys Trp Asp Thr Glu Ile Arg Leu Gln Leu Leu Thr Phe Ser Ala 
            500                 505                 510         
Met Cys Gln Asn Leu Ala Arg Thr Ala Glu Asp Asp Glu Thr Pro Val 
        515                 520                 525             
Asp Leu Asn Lys His Leu Tyr Gln Ile Glu Lys Pro Cys Lys Glu Ala 
    530                 535                 540                 
Met Thr Arg His Pro Val Glu Glu Leu Leu Asp Ser Tyr His Asn Gln 
545                 550                 555                 560 
Val Glu Leu Ala Leu Gln Ile Glu Asn Gln His Arg Ala Val Asp Gln 
                565                 570                 575     
Val Ile Lys Ala Val Arg Lys Ile Cys Ser Ala Leu Asp Gly Val Glu 
            580                 585                 590         
Thr Leu Ala Ile Thr Glu Ser Val Lys Lys Leu Lys Arg Ala Val Asn 
        595                 600                 605             
Leu Pro Arg Ser Lys Thr Ala Asp Val Thr Ser Leu Phe Gly Gly Glu 
    610                 615                 620                 
Asp Thr Ser Arg Ser Ser Thr Arg Gly Ser Leu Asn Pro Glu Asn Pro 
625                 630                 635                 640 
Val Gln Val Ser Ile Asn Gln Leu Thr Ala Ala Ile Tyr Asp Leu Leu 
                645                 650                 655     
Arg Leu His Ala Asn Ser Gly Arg Ser Pro Thr Asp Cys Ala Gln Ser 
            660                 665                 670         
Ser Lys Ser Val Lys Glu Ala Trp Thr Thr Thr Glu Gln Leu Gln Phe 
        675                 680                 685             
Thr Ile Phe Ala Ala His Gly Ile Ser Ser Asn Trp Val Ser Asn Tyr 
    690                 695                 700                 
Glu Lys Tyr Tyr Leu Ile Cys Ser Leu Ser His Asn Gly Lys Asp Leu 
705                 710                 715                 720 
Phe Lys Pro Ile Gln Ser Lys Lys Val Gly Thr Tyr Lys Asn Phe Phe 
                725                 730                 735     
Tyr Leu Ile Lys Trp Asp Glu Leu Ile Ile Phe Pro Ile Gln Ile Ser 
            740                 745                 750         
Gln Leu Pro Leu Glu Ser Val Leu His Leu Thr Leu Phe Gly Ile Leu 
        755                 760                 765             
Asn Gln Ser Ser Gly Ser Ser Pro Asp Ser Asn Lys Gln Arg Lys Gly 
    770                 775                 780                 
Pro Glu Ala Leu Gly Lys Val Ser Leu Pro Leu Phe Asp Phe Lys Arg 
785                 790                 795                 800 
Phe Leu Thr Cys Gly Thr Lys Leu Leu Tyr Leu Trp Thr Ser Ser His 
                805                 810                 815     
Thr Asn Ser Val Pro Gly Thr Val Thr Lys Lys Gly Tyr Val Met Glu 
            820                 825                 830         
Arg Ile Val Leu Gln Val Asp Phe Pro Ser Pro Ala Phe Asp Ile Ile 
        835                 840                 845             
Tyr Thr Thr Pro Gln Val Asp Arg Ser Ile Ile Gln Gln His Asn Leu 
    850                 855                 860                 
Glu Thr Leu Glu Asn Asp Ile Lys Gly Lys Leu Leu Asp Ile Leu His 
865                 870                 875                 880 
Lys Asp Ser Ser Leu Gly Leu Ser Lys Glu Asp Lys Ala Phe Leu Trp 
                885                 890                 895     
Glu Lys Arg Tyr Tyr Cys Phe Lys His Pro Asn Cys Leu Pro Lys Ile 
            900                 905                 910         
Leu Ala Ser Ala Pro Asn Trp Lys Trp Val Asn Leu Ala Lys Thr Tyr 
        915                 920                 925             
Ser Leu Leu His Gln Trp Pro Ala Leu Tyr Pro Leu Ile Ala Leu Glu 
    930                 935                 940                 
Leu Leu Asp Ser Lys Phe Ala Asp Gln Glu Val Arg Ser Leu Ala Val 
945                 950                 955                 960 
Thr Trp Ile Glu Ala Ile Ser Asp Asp Glu Leu Thr Asp Leu Leu Pro 
                965                 970                 975     
Gln Phe Val Gln Ala Leu Lys Tyr Glu Ile Tyr Leu Asn Ser Ser Leu 
            980                 985                 990         
Val Gln Phe Leu Leu Ser Arg Ala Leu Gly Asn Ile Gln Ile Ala His 
        995                 1000                1005            
Asn Leu Tyr Trp Leu Leu Lys Asp Ala Leu His Asp Val Gln Phe Ser 
    1010                1015                1020                
Thr Arg Tyr Glu His Val Leu Gly Ala Leu Leu Ser Val Gly Gly Lys 
1025                1030                1035                1040
Arg Leu Arg Glu Glu Leu Leu Lys Gln Thr Lys Leu Val Gln Leu Leu 
                1045                1050                1055    
Gly Gly Val Ala Glu Lys Val Arg Gln Ala Ser Gly Ser Ala Arg Gln 
            1060                1065                1070        
Val Val Leu Gln Arg Ser Met Glu Arg Val Gln Ser Phe Phe Gln Lys 
        1075                1080                1085            
Asn Lys Cys Arg Leu Pro Leu Lys Pro Ser Leu Val Ala Lys Glu Leu 
    1090                1095                1100                
Asn Ile Lys Ser Cys Ser Phe Phe Ser Ser Asn Ala Val Pro Leu Lys 
1105                1110                1115                1120
Val Thr Met Val Asn Ala Asp Pro Met Gly Glu Glu Ile Asn Val Met 
                1125                1130                1135    
Phe Lys Val Gly Glu Asp Leu Arg Gln Asp Met Leu Ala Leu Gln Met 
            1140                1145                1150        
Ile Lys Ile Met Asp Lys Ile Trp Leu Lys Glu Gly Leu Asp Leu Arg 
        1155                1160                1165            
Met Val Ile Phe Lys Cys Leu Ser Thr Gly Arg Asp Arg Gly Met Val 
    1170                1175                1180                
Glu Leu Val Pro Ala Ser Asp Thr Leu Arg Lys Ile Gln Val Glu Tyr 
1185                1190                1195                1200
Gly Val Thr Gly Ser Phe Lys Asp Lys Pro Leu Ala Glu Trp Leu Arg 
                1205                1210                1215    
Lys Tyr Asn Pro Ser Glu Glu Glu Tyr Glu Lys Ala Ser Glu Asn Phe 
            1220                1225                1230        
Ile Tyr Ser Cys Ala Gly Cys Cys Val Ala Thr Tyr Val Leu Gly Ile 
        1235                1240                1245            
Cys Asp Arg His Asn Asp Asn Ile Met Leu Arg Ser Thr Gly His Met 
    1250                1255                1260                
Phe His Ile Asp Phe Gly Lys Phe Leu Gly His Ala Gln Met Phe Gly 
1265                1270                1275                1280
Ser Phe Lys Arg Asp Arg Ala Pro Phe Val Leu Thr Ser Asp Met Ala 
                1285                1290                1295    
Tyr Val Ile Asn Gly Gly Glu Lys Pro Thr Ile Arg Phe Gln Leu Phe 
            1300                1305                1310        
Val Asp Leu Cys Cys Gln Ala Tyr Asn Leu Ile Arg Lys Gln Thr Asn 
        1315                1320                1325            
Leu Phe Leu Asn Leu Leu Ser Leu Met Ile Pro Ser Gly Leu Pro Glu 
    1330                1335                1340                
Leu Thr Ser Ile Gln Asp Leu Lys Tyr Val Arg Asp Ala Leu Gln Pro 
1345                1350                1355                1360
Gln Thr Thr Asp Ala Glu Ala Thr Ile Phe Phe Thr Arg Leu Ile Glu 
                1365                1370                1375    
Ser Ser Leu Gly Ser Ile Ala Thr Lys Phe Asn Phe Phe Ile His Asn 
            1380                1385                1390        
Leu Ala Gln Leu Arg Phe Ser Gly Leu Pro Ser Asn Asp Glu Pro Ile 
        1395                1400                1405            
Leu Ser Phe Ser Pro Lys Thr Tyr Ser Phe Arg Gln Asp Gly Arg Ile 
    1410                1415                1420                
Lys Glu Val Ser Val Phe Thr Tyr His Lys Lys Tyr Asn Pro Asp Lys 
1425                1430                1435                1440
His Tyr Ile Tyr Val Val Arg Ile Leu Arg Glu Gly Gln Ile Glu Pro 
                1445                1450                1455    
Ser Phe Val Phe Arg Thr Phe Asp Glu Phe Gln Glu Leu His Asn Lys 
            1460                1465                1470        
Leu Ser Ile Ile Phe Pro Leu Trp Lys Leu Pro Gly Phe Pro Asn Arg 
        1475                1480                1485            
Met Val Leu Gly Arg Thr His Ile Lys Asp Val Ala Ala Lys Arg Lys 
    1490                1495                1500                
Ile Glu Leu Asn Ser Tyr Leu Gln Ser Leu Met Asn Ala Ser Thr Asp 
1505                1510                1515                1520
Val Ala Glu Cys Asp Leu Val Cys Thr Phe Phe His Pro Leu Leu Arg 
                1525                1530                1535    
Asp Glu Lys Ala Glu Gly Ile Ala Arg Ser Ala Asp Ala Gly Ser Phe 
            1540                1545                1550        
Ser Pro Thr Pro Gly Gln Ile Gly Gly Ala Val Lys Leu Ser Ile Ser 
        1555                1560                1565            
Tyr Arg Asn Gly Thr Leu Phe Ile Met Val Met His Ile Lys Asp Leu 
    1570                1575                1580                
Val Thr Glu Asp Gly Ala Asp Pro Asn Pro Tyr Val Lys Thr Tyr Leu 
1585                1590                1595                1600
Leu Pro Asp Asn His Lys Thr Ser Lys Arg Lys Thr Lys Ile Ser Arg 
                1605                1610                1615    
Lys Thr Arg Asn Pro Thr Phe Asn Glu Met Leu Val Tyr Ser Gly Tyr 
            1620                1625                1630        
Ser Lys Glu Thr Leu Arg Gln Arg Glu Leu Gln Leu Ser Val Leu Ser 
        1635                1640                1645            
Ala Glu Ser Leu Arg Glu Asn Phe Phe Leu Gly Gly Val Thr Leu Pro 
    1650                1655                1660                
Leu Lys Asp Phe Asn Leu Ser Lys Glu Thr Val Lys Trp Tyr Gln Leu 
1665                1670                1675                1680
Thr Ala Ala Thr Tyr Leu 
                1685    

<210> 6
<211> 406
<212> PRT
<213> Homo sapiens


<220> 
<223> PDK3 human protein

<400> 6
Met Arg Leu Phe Arg Trp Leu Leu Lys Gln Pro Val Pro Lys Gln Ile 
1               5                   10                  15      
Glu Arg Tyr Ser Arg Phe Ser Pro Ser Pro Leu Ser Ile Lys Gln Phe 
            20                  25                  30          
Leu Asp Phe Gly Arg Asp Asn Ala Cys Glu Lys Thr Ser Tyr Met Phe 
        35                  40                  45              
Leu Arg Lys Glu Leu Pro Val Arg Leu Ala Asn Thr Met Arg Glu Val 
    50                  55                  60                  
Asn Leu Leu Pro Asp Asn Leu Leu Asn Arg Pro Ser Val Gly Leu Val 
65                  70                  75                  80  
Gln Ser Trp Tyr Met Gln Ser Phe Leu Glu Leu Leu Glu Tyr Glu Asn 
                85                  90                  95      
Lys Ser Pro Glu Asp Pro Gln Val Leu Asp Asn Phe Leu Gln Val Leu 
            100                 105                 110         
Ile Lys Val Arg Asn Arg His Asn Asp Val Val Pro Thr Met Ala Gln 
        115                 120                 125             
Gly Val Ile Glu Tyr Lys Glu Lys Phe Gly Phe Asp Pro Phe Ile Ser 
    130                 135                 140                 
Thr Asn Ile Gln Tyr Phe Leu Asp Arg Phe Tyr Thr Asn Arg Ile Ser 
145                 150                 155                 160 
Phe Arg Met Leu Ile Asn Gln His Thr Leu Leu Phe Gly Gly Asp Thr 
                165                 170                 175     
Asn Pro Val His Pro Lys His Ile Gly Ser Ile Asp Pro Thr Cys Asn 
            180                 185                 190         
Val Ala Asp Val Val Lys Asp Ala Tyr Glu Thr Ala Lys Met Leu Cys 
        195                 200                 205             
Glu Gln Tyr Tyr Leu Val Ala Pro Glu Leu Glu Val Glu Glu Phe Asn 
    210                 215                 220                 
Ala Lys Ala Pro Asp Lys Pro Ile Gln Val Val Tyr Val Pro Ser His 
225                 230                 235                 240 
Leu Phe His Met Leu Phe Glu Leu Phe Lys Asn Ser Met Arg Ala Thr 
                245                 250                 255     
Val Glu Leu Tyr Glu Asp Arg Lys Glu Gly Tyr Pro Ala Val Lys Thr 
            260                 265                 270         
Leu Val Thr Leu Gly Lys Glu Asp Leu Ser Ile Lys Ile Ser Asp Leu 
        275                 280                 285             
Gly Gly Gly Val Pro Leu Arg Lys Ile Asp Arg Leu Phe Asn Tyr Met 
    290                 295                 300                 
Tyr Ser Thr Ala Pro Arg Pro Ser Leu Glu Pro Thr Arg Ala Ala Pro 
305                 310                 315                 320 
Leu Ala Gly Phe Gly Tyr Gly Leu Pro Ile Ser Arg Leu Tyr Ala Arg 
                325                 330                 335     
Tyr Phe Gln Gly Asp Leu Lys Leu Tyr Ser Met Glu Gly Val Gly Thr 
            340                 345                 350         
Asp Ala Val Ile Tyr Leu Lys Ala Leu Ser Ser Glu Ser Phe Glu Arg 
        355                 360                 365             
Leu Pro Val Phe Asn Lys Ser Ala Trp Arg His Tyr Lys Thr Thr Pro 
    370                 375                 380                 
Glu Ala Asp Asp Trp Ser Asn Pro Ser Ser Glu Pro Arg Asp Ala Ser 
385                 390                 395                 400 
Lys Tyr Lys Ala Lys Gln 
                405     

<210> 7
<211> 999
<212> PRT
<213> Homo sapiens


<220> 
<223> MERTK human protein

<400> 7
Met Gly Pro Ala Pro Leu Pro Leu Leu Leu Gly Leu Phe Leu Pro Ala 
1               5                   10                  15      
Leu Trp Arg Arg Ala Ile Thr Glu Ala Arg Glu Glu Ala Lys Pro Tyr 
            20                  25                  30          
Pro Leu Phe Pro Gly Pro Phe Pro Gly Ser Leu Gln Thr Asp His Thr 
        35                  40                  45              
Pro Leu Leu Ser Leu Pro His Ala Ser Gly Tyr Gln Pro Ala Leu Met 
    50                  55                  60                  
Phe Ser Pro Thr Gln Pro Gly Arg Pro His Thr Gly Asn Val Ala Ile 
65                  70                  75                  80  
Pro Gln Val Thr Ser Val Glu Ser Lys Pro Leu Pro Pro Leu Ala Phe 
                85                  90                  95      
Lys His Thr Val Gly His Ile Ile Leu Ser Glu His Lys Gly Val Lys 
            100                 105                 110         
Phe Asn Cys Ser Ile Ser Val Pro Asn Ile Tyr Gln Asp Thr Thr Ile 
        115                 120                 125             
Ser Trp Trp Lys Asp Gly Lys Glu Leu Leu Gly Ala His His Ala Ile 
    130                 135                 140                 
Thr Gln Phe Tyr Pro Asp Asp Glu Val Thr Ala Ile Ile Ala Ser Phe 
145                 150                 155                 160 
Ser Ile Thr Ser Val Gln Arg Ser Asp Asn Gly Ser Tyr Ile Cys Lys 
                165                 170                 175     
Met Lys Ile Asn Asn Glu Glu Ile Val Ser Asp Pro Ile Tyr Ile Glu 
            180                 185                 190         
Val Gln Gly Leu Pro His Phe Thr Lys Gln Pro Glu Ser Met Asn Val 
        195                 200                 205             
Thr Arg Asn Thr Ala Phe Asn Leu Thr Cys Gln Ala Val Gly Pro Pro 
    210                 215                 220                 
Glu Pro Val Asn Ile Phe Trp Val Gln Asn Ser Ser Arg Val Asn Glu 
225                 230                 235                 240 
Gln Pro Glu Lys Ser Pro Ser Val Leu Thr Val Pro Gly Leu Thr Glu 
                245                 250                 255     
Met Ala Val Phe Ser Cys Glu Ala His Asn Asp Lys Gly Leu Thr Val 
            260                 265                 270         
Ser Lys Gly Val Gln Ile Asn Ile Lys Ala Ile Pro Ser Pro Pro Thr 
        275                 280                 285             
Glu Val Ser Ile Arg Asn Ser Thr Ala His Ser Ile Leu Ile Ser Trp 
    290                 295                 300                 
Val Pro Gly Phe Asp Gly Tyr Ser Pro Phe Arg Asn Cys Ser Ile Gln 
305                 310                 315                 320 
Val Lys Glu Ala Asp Pro Leu Ser Asn Gly Ser Val Met Ile Phe Asn 
                325                 330                 335     
Thr Ser Ala Leu Pro His Leu Tyr Gln Ile Lys Gln Leu Gln Ala Leu 
            340                 345                 350         
Ala Asn Tyr Ser Ile Gly Val Ser Cys Met Asn Glu Ile Gly Trp Ser 
        355                 360                 365             
Ala Val Ser Pro Trp Ile Leu Ala Ser Thr Thr Glu Gly Ala Pro Ser 
    370                 375                 380                 
Val Ala Pro Leu Asn Val Thr Val Phe Leu Asn Glu Ser Ser Asp Asn 
385                 390                 395                 400 
Val Asp Ile Arg Trp Met Lys Pro Pro Thr Lys Gln Gln Asp Gly Glu 
                405                 410                 415     
Leu Val Gly Tyr Arg Ile Ser His Val Trp Gln Ser Ala Gly Ile Ser 
            420                 425                 430         
Lys Glu Leu Leu Glu Glu Val Gly Gln Asn Gly Ser Arg Ala Arg Ile 
        435                 440                 445             
Ser Val Gln Val His Asn Ala Thr Cys Thr Val Arg Ile Ala Ala Val 
    450                 455                 460                 
Thr Arg Gly Gly Val Gly Pro Phe Ser Asp Pro Val Lys Ile Phe Ile 
465                 470                 475                 480 
Pro Ala His Gly Trp Val Asp Tyr Ala Pro Ser Ser Thr Pro Ala Pro 
                485                 490                 495     
Gly Asn Ala Asp Pro Val Leu Ile Ile Phe Gly Cys Phe Cys Gly Phe 
            500                 505                 510         
Ile Leu Ile Gly Leu Ile Leu Tyr Ile Ser Leu Ala Ile Arg Lys Arg 
        515                 520                 525             
Val Gln Glu Thr Lys Phe Gly Asn Ala Phe Thr Glu Glu Asp Ser Glu 
    530                 535                 540                 
Leu Val Val Asn Tyr Ile Ala Lys Lys Ser Phe Cys Arg Arg Ala Ile 
545                 550                 555                 560 
Glu Leu Thr Leu His Ser Leu Gly Val Ser Glu Glu Leu Gln Asn Lys 
                565                 570                 575     
Leu Glu Asp Val Val Ile Asp Arg Asn Leu Leu Ile Leu Gly Lys Ile 
            580                 585                 590         
Leu Gly Glu Gly Glu Phe Gly Ser Val Met Glu Gly Asn Leu Lys Gln 
        595                 600                 605             
Glu Asp Gly Thr Ser Leu Lys Val Ala Val Lys Thr Met Lys Leu Asp 
    610                 615                 620                 
Asn Ser Ser Gln Arg Glu Ile Glu Glu Phe Leu Ser Glu Ala Ala Cys 
625                 630                 635                 640 
Met Lys Asp Phe Ser His Pro Asn Val Ile Arg Leu Leu Gly Val Cys 
                645                 650                 655     
Ile Glu Met Ser Ser Gln Gly Ile Pro Lys Pro Met Val Ile Leu Pro 
            660                 665                 670         
Phe Met Lys Tyr Gly Asp Leu His Thr Tyr Leu Leu Tyr Ser Arg Leu 
        675                 680                 685             
Glu Thr Gly Pro Lys His Ile Pro Leu Gln Thr Leu Leu Lys Phe Met 
    690                 695                 700                 
Val Asp Ile Ala Leu Gly Met Glu Tyr Leu Ser Asn Arg Asn Phe Leu 
705                 710                 715                 720 
His Arg Asp Leu Ala Ala Arg Asn Cys Met Leu Arg Asp Asp Met Thr 
                725                 730                 735     
Val Cys Val Ala Asp Phe Gly Leu Ser Lys Lys Ile Tyr Ser Gly Asp 
            740                 745                 750         
Tyr Tyr Arg Gln Gly Arg Ile Ala Lys Met Pro Val Lys Trp Ile Ala 
        755                 760                 765             
Ile Glu Ser Leu Ala Asp Arg Val Tyr Thr Ser Lys Ser Asp Val Trp 
    770                 775                 780                 
Ala Phe Gly Val Thr Met Trp Glu Ile Ala Thr Arg Gly Met Thr Pro 
785                 790                 795                 800 
Tyr Pro Gly Val Gln Asn His Glu Met Tyr Asp Tyr Leu Leu His Gly 
                805                 810                 815     
His Arg Leu Lys Gln Pro Glu Asp Cys Leu Asp Glu Leu Tyr Glu Ile 
            820                 825                 830         
Met Tyr Ser Cys Trp Arg Thr Asp Pro Leu Asp Arg Pro Thr Phe Ser 
        835                 840                 845             
Val Leu Arg Leu Gln Leu Glu Lys Leu Leu Glu Ser Leu Pro Asp Val 
    850                 855                 860                 
Arg Asn Gln Ala Asp Val Ile Tyr Val Asn Thr Gln Leu Leu Glu Ser 
865                 870                 875                 880 
Ser Glu Gly Leu Ala Gln Gly Ser Thr Leu Ala Pro Leu Asp Leu Asn 
                885                 890                 895     
Ile Asp Pro Asp Ser Ile Ile Ala Ser Cys Thr Pro Arg Ala Ala Ile 
            900                 905                 910         
Ser Val Val Thr Ala Glu Val His Asp Ser Lys Pro His Glu Gly Arg 
        915                 920                 925             
Tyr Ile Leu Asn Gly Gly Ser Glu Glu Trp Glu Asp Leu Thr Ser Ala 
    930                 935                 940                 
Pro Ser Ala Ala Val Thr Ala Glu Lys Asn Ser Val Leu Pro Gly Glu 
945                 950                 955                 960 
Arg Leu Val Arg Asn Gly Val Ser Trp Ser His Ser Ser Met Leu Pro 
                965                 970                 975     
Leu Gly Ser Ser Leu Pro Asp Glu Leu Leu Phe Ala Asp Asp Ser Ser 
            980                 985                 990         
Glu Gly Ser Glu Val Leu Met 
        995                 

<210> 8
<211> 169
<212> PRT
<213> Homo sapiens


<220> 
<223> NME3 human protein

<400> 8
Met Ile Cys Leu Val Leu Thr Ile Phe Ala Asn Leu Phe Pro Ala Ala 
1               5                   10                  15      
Cys Thr Gly Ala His Glu Arg Thr Phe Leu Ala Val Lys Pro Asp Gly 
            20                  25                  30          
Val Gln Arg Arg Leu Val Gly Glu Ile Val Arg Arg Phe Glu Arg Lys 
        35                  40                  45              
Gly Phe Lys Leu Val Ala Leu Lys Leu Val Gln Ala Ser Glu Glu Leu 
    50                  55                  60                  
Leu Arg Glu His Tyr Ala Glu Leu Arg Glu Arg Pro Phe Tyr Gly Arg 
65                  70                  75                  80  
Leu Val Lys Tyr Met Ala Ser Gly Pro Val Val Ala Met Val Trp Gln 
                85                  90                  95      
Gly Leu Asp Val Val Arg Thr Ser Arg Ala Leu Ile Gly Ala Thr Asn 
            100                 105                 110         
Pro Ala Asp Ala Pro Pro Gly Thr Ile Arg Gly Asp Phe Cys Ile Glu 
        115                 120                 125             
Val Gly Lys Asn Leu Ile His Gly Ser Asp Ser Val Glu Ser Ala Arg 
    130                 135                 140                 
Arg Glu Ile Ala Leu Trp Phe Arg Ala Asp Glu Leu Leu Cys Trp Glu 
145                 150                 155                 160 
Asp Ser Ala Gly His Trp Leu Tyr Glu 
                165                 

<210> 9
<211> 32
<212> DNA
<213> Artificial Sequence


<220> 
<223> CASD1 PCR primer

<400> 9
gctcgggatc cgcggctctg gcctacaacc tg                                   32


<210> 10
<211> 37
<212> DNA
<213> Artificial Sequence


<220> 
<223> CASD1 PCR primer

<400> 10
gctcgctcga gatgttttga tttatcttga atggatg                              37


<210> 11
<211> 54
<212> DNA
<213> Artificial Sequence


<220> 
<223> V5 epitope pre-hybridized oligonucleotide

<400> 11
agcttcgaat gggtaagcct atccctaacc ctctcctcgg tctcgattct acgg           54


<210> 12
<211> 54
<212> DNA
<213> Artificial Sequence


<220> 
<223> V5 epitope pre-hybridized oligonucleotide

<400> 12
gatcccgtag aatcgagacc gaggagaggg ttagggatag gcttacccat tcga           54


<210> 13
<211> 42
<212> DNA
<213> Artificial Sequence


<220> 
<223> Myc epitope pre-hybridized oligonucleotide

<400> 13
tcgaggaaca aaaactcatc tcagaagagg atctgaatta at                        42


<210> 14
<211> 42
<212> DNA
<213> Artificial Sequence


<220> 
<223> Myc epitope pre-hybridized oligonucleotide

<400> 14
ctagattaat tcagatcctc ttctgagatg agtttttgtt cc                        42


<210> 15
<211> 33
<212> DNA
<213> Artificial Sequence


<220> 
<223> S94A mutagenesis primer

<400> 15
gcatttattg gagatgccag aattcgtcaa ttg                                  33


<210> 16
<211> 33
<212> DNA
<213> Artificial Sequence


<220> 
<223> S94A mutagenesis primer

<400> 16
caattgacga attctggcat ctccaataaa tgc                                  33


<210> 17
<211> 80
<212> DNA
<213> Artificial Sequence


<220> 
<223> ST8SIA1 PCR primer (G3DS)

<400> 17
gctaagcttc gaatgggtaa gcctatccct aaccctctcc tcggtctcga ttctacgggt     60

accagcccct gcgggcgggc                                                 80


<210> 18
<211> 31
<212> DNA
<213> Artificial Sequence


<220> 
<223> ST8SIA1 PCR primer (G3DS)

<400> 18
gctgcggccg cctaggaagt gggctggagt g                                   31


<210> 19
<211> 20
<212> PRT
<213> Artificial Sequence


<220> 
<223> self-cleaving 2A peptide of equine rhinitis A virus

<400> 19
Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp Val Glu Ser 
1               5                   10                  15      
Asn Pro Gly Pro 
            20  

<210> 20
<211> 25
<212> DNA
<213> Artificial Sequence


<220> 
<223> GD3S/self-cleaving 2A peptide/GD2S PCR primer

<400> 20
atagcggccg catgagcccc tgcgg                                          25


<210> 21
<211> 29
<212> DNA
<213> Artificial Sequence


<220> 
<223> GD3S/self-cleaving 2A peptide/GD2S PCR primer

<400> 21
gctctctaga tcactcggcg gtcatgcac                                      29


<210> 22
<211> 23
<212> DNA
<213> Artificial Sequence


<220> 
<223> exon 2-specific target sequence

<400> 22
ttgcatttat cggagattcc agg                                            23


<210> 23
<211> 18
<212> DNA
<213> Artificial Sequence


<220> 
<223> Target region PCR primer

<400> 23
gctgtgccta acagtttg                                                  18


<210> 24
<211> 19
<212> DNA
<213> Artificial Sequence


<220> 
<223> Target region PCR primer

<400> 24
tggcaagttt ttccatgag                                                 19


<210> 25
<211> 24
<212> DNA
<213> Artificial Sequence


<220> 
<223> Target region PCR primer

<400> 25
tgaagcaaag aattgccttg taga                                           24


<210> 26
<211> 26
<212> DNA
<213> Artificial Sequence


<220> 
<223> Target region PCR primer

<400> 26
cttatttcct tcttctttaa actggg                                         26


<210> 27
<211> 18
<212> DNA
<213> Artificial Sequence


<220> 
<223> CASD1 PCR primer

<400> 27
atgttcacaa cgccacgg                                                  18


<210> 28
<211> 18
<212> DNA
<213> Artificial Sequence


<220> 
<223> CASD1 PCR primer

<400> 28
caggaaccat ccacaggc                                                  18


<210> 29
<211> 33
<212> DNA
<213> Artificial Sequence


<220> 
<223> NeuD PCR primer

<400> 29
cgccgcggat ccgaaaaaat aaccttaaaa tgc                                  33


<210> 30
<211> 44
<212> DNA
<213> Artificial Sequence


<220> 
<223> NeuD PCR primer

<400> 30
gtccgctcga gttaaaatag attaaaaatt ttttttgatt ttag                      44


<210> 31
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> CASD1 PCR primer

<400> 31
gtggattttc tgtggcatcc                                                20


<210> 32
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> CASD1 PCR primer

<400> 32
aagcgcttca ctgctaccat                                                20


<210> 33
<211> 21
<212> DNA
<213> Artificial Sequence


<220> 
<223> B4GALNT1 PCR primer (G2DS)

<400> 33
cagcgctcta gtcacgattg c                                              21


<210> 34
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> B4GALNT1 PCR primer (G2DS)

<400> 34
ccacggtaac cgttgggtag                                                20


<210> 35
<211> 19
<212> DNA
<213> Artificial Sequence


<220> 
<223> ST8SIA1 PCR primer (G3DS)

<400> 35
gcgatgcaat ctccctcct                                                 19


<210> 36
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> ST8SIA1 PCR primer

<400> 36
ttcccgaatt atgctgggat                                                20


<210> 37
<211> 12
<212> PRT
<213> Artificial Sequence


<220> 
<223> 8B6 mAb LC-CDR1

<400> 37
Gln Ser Leu Leu Lys Asn Asn Gly Asn Thr Phe Leu 
1               5                   10          

<210> 38
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> 8B6 mAb LC-CDR3

<400> 38
Ser Gln Ser Thr His Ile Pro Tyr Thr 
1               5                   

<210> 39
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> 8B6 mAb HC-CDR1

<400> 39
Glu Phe Thr Phe Thr Asp Tyr Tyr 
1               5               

<210> 40
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> 8B6 mAb HC-CDR2

<400> 40
Ile Arg Asn Arg Ala Asn Gly Tyr Thr Thr 
1               5                   10  

<210> 41
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> 8B6 mAb HC-CDR3

<400> 41
Ala Arg Val Ser Asn Trp Ala Phe Asp Tyr 
1               5                   10  

<210> 42
<211> 112
<212> PRT
<213> Artificial Sequence


<220> 
<221> SITE
<222> 1
<223> X=D or E

<220> 
<223> Humanized anti-OAcGD2 VL consensus sequence

<220> 
<221> SITE
<222> 2
<223> X=V or I

<220> 
<221> SITE
<222> 9
<223> X=L or A

<220> 
<221> SITE
<222> 10
<223> X=S or T

<220> 
<221> SITE
<222> 12
<223> X=P or S

<220> 
<221> SITE
<222> 13
<223> X=V or L or A

<220> 
<221> SITE
<222> 14
<223> X=S or T

<220> 
<221> SITE
<222> 15
<223> X=L or P or V

<220> 
<221> SITE
<222> 17
<223> X=D or Q or E

<220> 
<221> SITE
<222> 18
<223> X=Q or P or R

<220> 
<221> SITE
<222> 19
<223> X=A or V

<220> 
<221> SITE
<222> 20
<223> X=S or T

<220> 
<221> SITE
<222> 21
<223> X=I or L

<220> 
<221> SITE
<222> 22
<223> X=S or T

<220> 
<221> SITE
<222> 25
<223> X=S or A

<220> 
<221> SITE
<222> 29
<223> X=L or V

<220> 
<221> SITE
<222> 30
<223> X=L or V

<220> 
<221> SITE
<222> 32
<223> X=N or S

<220> 
<221> SITE
<222> 33
<223> X=N or Q

<220> 
<221> SITE
<222> 34
<223> X=G or A or S

<220> 
<221> SITE
<222> 35
<223> X=N or Y or S

<220> 
<221> SITE
<222> 36
<223> X=T or N or S

<220> 
<221> SITE
<222> 37
<223> X=F or Y

<220> 
<221> SITE
<222> 39
<223> X=H or N or S or A or Y or G

<220> 
<221> SITE
<222> 41
<223> X=Y or F

<220> 
<221> SITE
<222> 42
<223> X=L or Q

<220> 
<221> SITE
<222> 44
<223> X=K or R

<220> 
<221> SITE
<222> 47
<223> X=Q or K

<220> 
<221> SITE
<222> 48
<223> X=S or A or V

<220> 
<221> SITE
<222> 50
<223> X=K or Q or R

<220> 
<221> SITE
<222> 51
<223> X=L or R or V

<220> 
<221> SITE
<222> 55
<223> X=K or G or L

<220> 
<221> SITE
<222> 56
<223> X=V or A or G

<220> 
<221> SITE
<222> 58
<223> X=N or T

<220> 
<221> SITE
<222> 60
<223> X=L or D or A

<220> 
<221> SITE
<222> 61
<223> X=S or T

<220> 
<221> SITE
<222> 63
<223> X=V or I

<220> 
<221> SITE
<222> 65
<223> X=D or A or S

<220> 
<221> SITE
<222> 75
<223> X=Y or D

<220> 
<221> SITE
<222> 79
<223> X=K or T

<220> 
<221> SITE
<222> 81
<223> X=S or N

<220> 
<221> SITE
<222> 82
<223> X=R or S

<220> 
<221> SITE
<222> 83
<223> X=V or L

<220> 
<221> SITE
<222> 84
<223> X=E or Q

<220> 
<221> SITE
<222> 85
<223> X=A or P

<220> 
<221> SITE
<222> 88
<223> X=L or V or F

<220> 
<221> SITE
<222> 89
<223> X=G or A

<220> 
<221> SITE
<222> 90
<223> X=V or T

<220> 
<221> SITE
<222> 92
<223> X=F or Y

<220> 
<221> SITE
<222> 94
<223> X=S or M or Q

<220> 
<221> SITE
<222> 96
<223> X=S or A

<220> 
<221> SITE
<222> 97
<223> X=T or Y

<220> 
<221> SITE
<222> 98
<223> X=H or Q or N

<220> 
<221> SITE
<222> 99
<223> X=I or T or Q

<220> 
<221> SITE
<222> 100
<223> X=P or S

<220> 
<221> SITE
<222> 105
<223> X=G or Q

<400> 42
Xaa Xaa Val Met Thr Gln Ser Pro Xaa Xaa Leu Xaa Xaa Xaa Xaa Gly 
1               5                   10                  15      
Xaa Xaa Xaa Xaa Xaa Xaa Cys Arg Xaa Ser Gln Ser Xaa Xaa Lys Xaa 
            20                  25                  30          
Xaa Xaa Xaa Xaa Xaa Leu Xaa Trp Xaa Xaa Gln Xaa Pro Gly Xaa Xaa 
        35                  40                  45              
Pro Xaa Xaa Leu Ile Tyr Xaa Xaa Ser Xaa Arg Xaa Xaa Gly Xaa Pro 
    50                  55                  60                  
Xaa Arg Phe Ser Gly Ser Gly Ser Gly Thr Xaa Phe Thr Leu Xaa Ile 
65                  70                  75                  80  
Xaa Xaa Xaa Xaa Xaa Glu Asp Xaa Xaa Xaa Tyr Xaa Cys Xaa Gln Xaa 
                85                  90                  95      
Xaa Xaa Xaa Xaa Tyr Thr Phe Gly Xaa Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         



<210> 43
<211> 119
<212> PRT
<213> Artificial Sequence


<220> 
<221> SITE
<222> 1
<223> X=E or Q

<220> 
<223> Humanized anti-OAcGD2 VH consensus sequence

<220> 
<221> SITE
<222> 5
<223> X=V or L

<220> 
<221> SITE
<222> 13
<223> X=Q or K

<220> 
<221> SITE
<222> 16
<223> X=G or R

<220> 
<221> SITE
<222> 23
<223> X=A or T

<220> 
<221> SITE
<222> 24
<223> X=T or A

<220> 
<221> SITE
<222> 26
<223> X=E or G

<220> 
<221> SITE
<222> 30
<223> X=T or S or G

<220> 
<221> SITE
<222> 32
<223> X=Y or H

<220> 
<221> SITE
<222> 35
<223> X=T or H or N or S

<220> 
<221> SITE
<222> 37
<223> X=V or I

<220> 
<221> SITE
<222> 48
<223> X= L or V

<220> 
<221> SITE
<222> 49
<223> X= G or S

<220> 
<221> SITE
<222> 50
<223> X= F or Y

<220> 
<221> SITE
<222> 51
<223> X= I or T

<220> 
<221> SITE
<222> 54
<223> X= R or K or S

<220> 
<221> SITE
<222> 55
<223> X= A or S

<220> 
<221> SITE
<222> 56
<223> X=N or S

<220> 
<221> SITE
<222> 57
<223> X= G or A or S

<220> 
<221> SITE
<222> 58
<223> X= Y or G

<220> 
<221> SITE
<222> 59
<223> X= T or I

<220> 
<221> SITE
<222> 60
<223> X= T or I

<220> 
<221> SITE
<222> 61
<223> X= E or Y

<220> 
<221> SITE
<222> 63
<223> X= N or A

<220> 
<221> SITE
<222> 64
<223> X= P or A or D

<220> 
<221> SITE
<222> 76
<223> X= N or G

<220> 
<221> SITE
<222> 77
<223> X= S or A

<220> 
<221> SITE
<222> 79
<223> X= S or N

<220> 
<221> SITE
<222> 80
<223> X= I or S or T

<220> 
<221> SITE
<222> 81
<223> X= L or T or A

<220> 
<221> SITE
<222> 89
<223> X= R or K or Q

<220> 
<221> SITE
<222> 90
<223> X= T or A

<220> 
<221> SITE
<222> 95
<223> X= V or I or L

<220> 
<221> SITE
<222> 99
<223> X= A or T

<220> 
<221> SITE
<222> 105
<223> X=A or Y

<220> 
<221> SITE
<222> 114
<223> X= T or L

<220> 
<221> SITE
<222> 115
<223> X= L or V

<400> 43
Xaa Val Gln Leu Xaa Glu Ser Gly Gly Gly Leu Val Xaa Pro Gly Xaa 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Xaa Xaa Ser Xaa Phe Thr Phe Xaa Asp Xaa 
            20                  25                  30          
Tyr Met Xaa Trp Xaa Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Xaa 
        35                  40                  45              
Xaa Xaa Xaa Arg Asn Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Tyr Xaa Xaa 
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Xaa Xaa Lys Xaa Xaa 
65                  70                  75                  80  
Xaa Tyr Leu Gln Met Asn Ser Leu Xaa Xaa Glu Asp Thr Ala Xaa Tyr 
                85                  90                  95      
Tyr Cys Xaa Arg Val Ser Asn Trp Xaa Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         
Thr Xaa Xaa Thr Val Ser Ser 
        115                 

<210> 44
<211> 119
<212> PRT
<213> Artificial Sequence


<220> 
<223> Anti-OAcGD2 VH49A

<400> 44
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Thr Thr Ser Glu Phe Thr Phe Thr Asp Tyr 
            20                  25                  30          
Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              
Gly Phe Ile Arg Asn Arg Ala Asn Gly Tyr Thr Thr Glu Tyr Asn Pro 
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Ser Ile 
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      
Tyr Cys Ala Arg Val Ser Asn Trp Ala Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser 
        115                 

<210> 45
<211> 119
<212> PRT
<213> Artificial Sequence


<220> 
<223> Anti-OAcGD2 VH72A

<400> 45
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Thr Ser Glu Phe Thr Phe Thr Asp Tyr 
            20                  25                  30          
Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              
Gly Phe Ile Arg Asn Arg Ala Asn Gly Tyr Thr Thr Glu Tyr Asn Pro 
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Ser 
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      
Tyr Cys Ala Arg Val Ser Asn Trp Ala Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser 
        115                 

<210> 46
<211> 119
<212> PRT
<213> Artificial Sequence


<220> 
<223> Anti-OAcGD2 VH49BHS

<400> 46
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Thr Thr Ser Glu Phe Thr Phe Thr Asp Tyr 
            20                  25                  30          
Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              
Gly Phe Ile Arg Asn Lys Ala Asn Gly Tyr Thr Thr Glu Tyr Asn Pro 
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Ser Ile 
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      
Tyr Cys Ala Arg Val Ser Asn Trp Ala Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser 
        115                 

<210> 47
<211> 119
<212> PRT
<213> Artificial Sequence


<220> 
<223> Anti-OAcGD2 VH72BHNPS

<400> 47
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Thr Ser Glu Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          
Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              
Gly Phe Ile Arg Asn Lys Ala Asn Gly Tyr Thr Thr Glu Tyr Asn Pro 
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Ser 
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      
Tyr Cys Ala Arg Val Ser Asn Trp Ala Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser 
        115                 

<210> 48
<211> 112
<212> PRT
<213> Artificial Sequence


<220> 
<223> Anti-OAcGD2 VL30A

<400> 48
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Lys Asn 
            20                  25                  30          
Asn Gly Asn Thr Phe Leu His Trp Tyr Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              
Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Leu Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      
Thr His Ile Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         



<210> 49
<211> 112
<212> PRT
<213> Artificial Sequence


<220> 
<223> Anti-OAcGD2 VL 28A

<400> 49
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Lys Asn 
            20                  25                  30          
Asn Gly Asn Thr Phe Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Leu Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      
Thr His Ile Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         



<210> 50
<211> 112
<212> PRT
<213> Artificial Sequence


<220> 
<223> Anti-OAcGD2 VL 28Bs01/A2

<400> 50
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Lys Ser 
            20                  25                  30          
Asn Ala Asn Thr Phe Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Leu Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ser 
                85                  90                  95      
Thr His Ile Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         



<210> 51
<211> 112
<212> PRT
<213> Artificial Sequence


<220> 
<223> Humanized anti-OAcGD2 VL consensus sequence

<220> 
<221> SITE
<222> 2
<223> X=V or I

<220> 
<221> SITE
<222> 14
<223> X=S or T

<220> 
<221> SITE
<222> 15
<223> X=L or P

<220> 
<221> SITE
<222> 17
<223> X=D or Q or E

<220> 
<221> SITE
<222> 18
<223> X=Q or P

<220> 
<221> SITE
<222> 30
<223> X=L or V

<220> 
<221> SITE
<222> 32
<223> X=N or S

<220> 
<221> SITE
<222> 34
<223> X= G or A

<220> 
<221> SITE
<222> 37
<223> X=F or Y

<220> 
<221> SITE
<222> 41
<223> X=Y or F

<220> 
<221> SITE
<222> 42
<223> X=L or Q

<220> 
<221> SITE
<222> 44
<223> X=K or R

<220> 
<221> SITE
<222> 50
<223> X=K or Q or R

<220> 
<221> SITE
<222> 60
<223> X=L or A

<220> 
<221> SITE
<222> 75
<223> X=Y or D

<220> 
<221> SITE
<222> 88
<223> X=L or V

<220> 
<221> SITE
<222> 92
<223> X=F or Y

<220> 
<221> SITE
<222> 94
<223> X=S or M

<220> 
<221> SITE
<222> 105
<223> X=G or Q

<400> 51
Asp Xaa Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Xaa Xaa Gly 
1               5                   10                  15      
Xaa Xaa Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Xaa Lys Xaa 
            20                  25                  30          
Asn Xaa Asn Thr Xaa Leu His Trp Xaa Xaa Gln Xaa Pro Gly Gln Ser 
        35                  40                  45              
Pro Xaa Leu Leu Ile Tyr Lys Val Ser Asn Arg Xaa Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Xaa Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Xaa Gly Val Tyr Xaa Cys Xaa Gln Ser 
                85                  90                  95      
Thr His Ile Pro Tyr Thr Phe Gly Xaa Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         



<210> 52
<211> 119
<212> PRT
<213> Artificial Sequence


<220> 
<223> Humanized anti-OAcGD2 VH consensus sequence

<220> 
<221> SITE
<222> 16
<223> X=G or R

<220> 
<221> SITE
<222> 23
<223> X=A or T

<220> 
<221> SITE
<222> 24
<223> X=T or A

<220> 
<221> SITE
<222> 26
<223> X=E or G

<220> 
<221> SITE
<222> 30
<223> X=T or S or G

<220> 
<221> SITE
<222> 32
<223> X=Y or H

<220> 
<221> SITE
<222> 35
<223> X=T or S

<220> 
<221> SITE
<222> 54
<223> X= R or K

<220> 
<221> SITE
<222> 56
<223> X=N or S

<220> 
<221> SITE
<222> 57
<223> X= G or S or A

<220> 
<221> SITE
<222> 58
<223> X= Y or G

<220> 
<221> SITE
<222> 60
<223> X= T or I

<220> 
<221> SITE
<222> 61
<223> X= E or Y

<220> 
<221> SITE
<222> 63
<223> X= N or A

<220> 
<221> SITE
<222> 64
<223> X= P or A

<220> 
<221> SITE
<222> 79
<223> X= S or N

<220> 
<221> SITE
<222> 80
<223> X= I or S

<220> 
<221> SITE
<222> 81
<223> X= L or A

<220> 
<221> SITE
<222> 89
<223> X= R or K

<220> 
<221> SITE
<222> 99
<223> X= A or T

<220> 
<221> SITE
<222> 114
<223> X= T or L

<220> 
<221> SITE
<222> 115
<223> X= L or V

<400> 52
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Xaa 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Xaa Xaa Ser Xaa Phe Thr Phe Xaa Asp Xaa 
            20                  25                  30          
Tyr Met Xaa Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              
Gly Phe Ile Arg Asn Xaa Ala Xaa Xaa Xaa Thr Xaa Xaa Tyr Xaa Xaa 
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Xaa Xaa 
65                  70                  75                  80  
Xaa Tyr Leu Gln Met Asn Ser Leu Xaa Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      
Tyr Cys Xaa Arg Val Ser Asn Trp Ala Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         
Thr Xaa Xaa Thr Val Ser Ser 
        115                 

<210> 53
<211> 751
<212> PRT
<213> Homo sapiens


<220> 
<223> EZH2 human protein

<400> 53
Met Gly Gln Thr Gly Lys Lys Ser Glu Lys Gly Pro Val Cys Trp Arg 
1               5                   10                  15      
Lys Arg Val Lys Ser Glu Tyr Met Arg Leu Arg Gln Leu Lys Arg Phe 
            20                  25                  30          
Arg Arg Ala Asp Glu Val Lys Ser Met Phe Ser Ser Asn Arg Gln Lys 
        35                  40                  45              
Ile Leu Glu Arg Thr Glu Ile Leu Asn Gln Glu Trp Lys Gln Arg Arg 
    50                  55                  60                  
Ile Gln Pro Val His Ile Leu Thr Ser Val Ser Ser Leu Arg Gly Thr 
65                  70                  75                  80  
Arg Glu Cys Ser Val Thr Ser Asp Leu Asp Phe Pro Thr Gln Val Ile 
                85                  90                  95      
Pro Leu Lys Thr Leu Asn Ala Val Ala Ser Val Pro Ile Met Tyr Ser 
            100                 105                 110         
Trp Ser Pro Leu Gln Gln Asn Phe Met Val Glu Asp Glu Thr Val Leu 
        115                 120                 125             
His Asn Ile Pro Tyr Met Gly Asp Glu Val Leu Asp Gln Asp Gly Thr 
    130                 135                 140                 
Phe Ile Glu Glu Leu Ile Lys Asn Tyr Asp Gly Lys Val His Gly Asp 
145                 150                 155                 160 
Arg Glu Cys Gly Phe Ile Asn Asp Glu Ile Phe Val Glu Leu Val Asn 
                165                 170                 175     
Ala Leu Gly Gln Tyr Asn Asp Asp Asp Asp Asp Asp Asp Gly Asp Asp 
            180                 185                 190         
Pro Glu Glu Arg Glu Glu Lys Gln Lys Asp Leu Glu Asp His Arg Asp 
        195                 200                 205             
Asp Lys Glu Ser Arg Pro Pro Arg Lys Phe Pro Ser Asp Lys Ile Phe 
    210                 215                 220                 
Glu Ala Ile Ser Ser Met Phe Pro Asp Lys Gly Thr Ala Glu Glu Leu 
225                 230                 235                 240 
Lys Glu Lys Tyr Lys Glu Leu Thr Glu Gln Gln Leu Pro Gly Ala Leu 
                245                 250                 255     
Pro Pro Glu Cys Thr Pro Asn Ile Asp Gly Pro Asn Ala Lys Ser Val 
            260                 265                 270         
Gln Arg Glu Gln Ser Leu His Ser Phe His Thr Leu Phe Cys Arg Arg 
        275                 280                 285             
Cys Phe Lys Tyr Asp Cys Phe Leu His Arg Lys Cys Asn Tyr Ser Phe 
    290                 295                 300                 
His Ala Thr Pro Asn Thr Tyr Lys Arg Lys Asn Thr Glu Thr Ala Leu 
305                 310                 315                 320 
Asp Asn Lys Pro Cys Gly Pro Gln Cys Tyr Gln His Leu Glu Gly Ala 
                325                 330                 335     
Lys Glu Phe Ala Ala Ala Leu Thr Ala Glu Arg Ile Lys Thr Pro Pro 
            340                 345                 350         
Lys Arg Pro Gly Gly Arg Arg Arg Gly Arg Leu Pro Asn Asn Ser Ser 
        355                 360                 365             
Arg Pro Ser Thr Pro Thr Ile Asn Val Leu Glu Ser Lys Asp Thr Asp 
    370                 375                 380                 
Ser Asp Arg Glu Ala Gly Thr Glu Thr Gly Gly Glu Asn Asn Asp Lys 
385                 390                 395                 400 
Glu Glu Glu Glu Lys Lys Asp Glu Thr Ser Ser Ser Ser Glu Ala Asn 
                405                 410                 415     
Ser Arg Cys Gln Thr Pro Ile Lys Met Lys Pro Asn Ile Glu Pro Pro 
            420                 425                 430         
Glu Asn Val Glu Trp Ser Gly Ala Glu Ala Ser Met Phe Arg Val Leu 
        435                 440                 445             
Ile Gly Thr Tyr Tyr Asp Asn Phe Cys Ala Ile Ala Arg Leu Ile Gly 
    450                 455                 460                 
Thr Lys Thr Cys Arg Gln Val Tyr Glu Phe Arg Val Lys Glu Ser Ser 
465                 470                 475                 480 
Ile Ile Ala Pro Ala Pro Ala Glu Asp Val Asp Thr Pro Pro Arg Lys 
                485                 490                 495     
Lys Lys Arg Lys His Arg Leu Trp Ala Ala His Cys Arg Lys Ile Gln 
            500                 505                 510         
Leu Lys Lys Asp Gly Ser Ser Asn His Val Tyr Asn Tyr Gln Pro Cys 
        515                 520                 525             
Asp His Pro Arg Gln Pro Cys Asp Ser Ser Cys Pro Cys Val Ile Ala 
    530                 535                 540                 
Gln Asn Phe Cys Glu Lys Phe Cys Gln Cys Ser Ser Glu Cys Gln Asn 
545                 550                 555                 560 
Arg Phe Pro Gly Cys Arg Cys Lys Ala Gln Cys Asn Thr Lys Gln Cys 
                565                 570                 575     
Pro Cys Tyr Leu Ala Val Arg Glu Cys Asp Pro Asp Leu Cys Leu Thr 
            580                 585                 590         
Cys Gly Ala Ala Asp His Trp Asp Ser Lys Asn Val Ser Cys Lys Asn 
        595                 600                 605             
Cys Ser Ile Gln Arg Gly Ser Lys Lys His Leu Leu Leu Ala Pro Ser 
    610                 615                 620                 
Asp Val Ala Gly Trp Gly Ile Phe Ile Lys Asp Pro Val Gln Lys Asn 
625                 630                 635                 640 
Glu Phe Ile Ser Glu Tyr Cys Gly Glu Ile Ile Ser Gln Asp Glu Ala 
                645                 650                 655     
Asp Arg Arg Gly Lys Val Tyr Asp Lys Tyr Met Cys Ser Phe Leu Phe 
            660                 665                 670         
Asn Leu Asn Asn Asp Phe Val Val Asp Ala Thr Arg Lys Gly Asn Lys 
        675                 680                 685             
Ile Arg Phe Ala Asn His Ser Val Asn Pro Asn Cys Tyr Ala Lys Val 
    690                 695                 700                 
Met Met Val Asn Gly Asp His Arg Ile Gly Ile Phe Ala Lys Arg Ala 
705                 710                 715                 720 
Ile Gln Thr Gly Glu Glu Leu Phe Phe Asp Tyr Arg Tyr Ser Gln Ala 
                725                 730                 735     
Asp Ala Leu Lys Tyr Val Gly Ile Glu Arg Glu Met Glu Ile Pro 
            740                 745                 750     

<210> 54
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> HPRT PCR primer (forward)

<400> 54
gccagacttt gttggatttg                                                20


<210> 55
<211> 25
<212> DNA
<213> Artificial Sequence


<220> 
<223> HPRT PCR primer (reverse)

<400> 55
ctctcatctt aggctttgta ttttg                                          25


