                         SEQUENCE LISTING

<110>  Dragonstone Holding (Hong Kong) Limited
 
<120>  Therapeutics and Methods for Treating or Ameliorating Metabolic Disorders

<130>  191150.00102

<150>  63/208,717
<151>  2021-06-09

<160>  96    

<170>  PatentIn version 3.5

<210>  1
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1

Ser Ala Ser Ser Val Ser Tyr Met His 
1               5                   


<210>  2
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2

Ser Ile Ser Asn Leu Ala Ser 
1               5           


<210>  3
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3

Leu Gln Arg Ser Thr Tyr Pro Tyr Thr 
1               5                   


<210>  4
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4

Ser Gly Phe Ser Phe Thr Gly Tyr Asn Met Asn 
1               5                   10      


<210>  5
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  5

Asn Ile Asp Pro Tyr Tyr Gly Val Thr Asp Tyr Asn Leu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  6
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  6

Ala Ser Leu Leu Leu Asp Tyr 
1               5           


<210>  7
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7

Arg Ala Ser Ser Ser Val Ser Tyr Leu Ala 
1               5                   10  


<210>  8
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  8

Ser Ile Ser Asn Arg Ala Thr 
1               5           


<210>  9
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  9

Gln Gln Arg Ser Thr Tyr Pro Tyr Thr 
1               5                   


<210>  10
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  10

Ser Ala Ser Ser Ser Val Ser Tyr Leu His 
1               5                   10  


<210>  11
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  11

Asn Ile Asn Pro Tyr Tyr Gly Val Thr Asp Tyr Asn Leu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  12
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  12

Arg Ser Ser Gln Ser Leu Glu Asn Ser Asn Gly Asn Thr Phe Leu Ser 
1               5                   10                  15      


<210>  13
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  13

Arg Val Ser Asn Arg Phe Ser 
1               5           


<210>  14
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  14

Leu Gln Val Thr His Ala Pro Pro Thr 
1               5                   


<210>  15
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  15

Ser Gly Phe Ser Leu Thr Arg Tyr Asp Ile Ser 
1               5                   10      


<210>  16
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  16

Val Ile Trp Thr Asp Gly Gly Thr Asn Tyr Asn Ser Ala Phe Lys Pro 
1               5                   10                  15      


<210>  17
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  17

Val Arg Gly Ala His Tyr Ser Gly Asp Tyr Phe Asp Tyr 
1               5                   10              


<210>  18
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  18

Arg Ala Gly Gln Glu Ile Asn Gly Tyr Leu Ser 
1               5                   10      


<210>  19
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  19

Ala Ala Ser Thr Leu Asp Ser 
1               5           


<210>  20
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  20

Leu Gln Tyr Ala Ser Tyr Pro Leu Thr 
1               5                   


<210>  21
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  21

Ser Gly Phe Thr Phe Ser Asn Tyr Gly Met Ser 
1               5                   10      


<210>  22
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  22

Ser Ile Ser Ser Gly Gly Ala Thr Tyr Tyr Pro Asp Thr Val Lys Gly 
1               5                   10                  15      


<210>  23
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  23

Ala Pro Tyr Tyr Lys Tyr Asp Tyr Gly Met Asp Tyr 
1               5                   10          


<210>  24
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  24

Arg Ser Ser Gln Ser Leu Leu His Arg Asn Gly Asn Ile Tyr Leu His 
1               5                   10                  15      


<210>  25
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  25

Thr Val Ser Asn Arg Phe Ser 
1               5           


<210>  26
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  26

Ser Gln Ser Ile His Val Pro Pro Thr 
1               5                   


<210>  27
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  27

Ser Gly Tyr Ile Phe Thr Asn Tyr Gly Met Asn 
1               5                   10      


<210>  28
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  28

Trp Ile Asn Thr Tyr Thr Gly Glu Pro Ser Tyr Thr Asp Asp Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  29
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  29

Val Lys Thr Thr Gly Tyr Phe Met Asp Tyr 
1               5                   10  


<210>  30
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  30

Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  31
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  31

Ser Thr Ser Arg Leu His Ser 
1               5           


<210>  32
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  32

Gln Gln Arg Tyr Thr Leu Pro Arg Thr 
1               5                   


<210>  33
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  33

Ser Gly Phe Thr Phe Thr Ser Tyr Thr Leu His 
1               5                   10      


<210>  34
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  34

Tyr Ile Thr Pro Tyr Asn Gly Glu Thr His Tyr Asn Glu Lys Phe Thr 
1               5                   10                  15      


Gly 
    


<210>  35
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  35

Ala Arg Glu Ala Phe Trp Tyr Gly Asp Ser Phe Ala Met Asp Tyr 
1               5                   10                  15  


<210>  36
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  36

Arg Ala Ser Gln Gly Ile Ser Gly Phe Leu Asn 
1               5                   10      


<210>  37
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  37

Ala Thr Ser Phe Leu Glu Ser 
1               5           


<210>  38
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  38

Gln Gln Ser Tyr Thr Thr Pro Leu Thr 
1               5                   


<210>  39
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  39

Gly Gly Ser Phe Ser Gly Tyr Ala Ile Ser 
1               5                   10  


<210>  40
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  40

Gly Val Ile Pro Ile Phe Gly Ile Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  41
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  41

Ala Arg Thr Met Ile Val Ala Asp Tyr Tyr Tyr Gly Met Asp Val 
1               5                   10                  15  


<210>  42
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  42

Ala Arg Thr Leu Ile Val Ala Asp Tyr Tyr Tyr Gly Met Asp Val 
1               5                   10                  15  


<210>  43
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  43

Ala Arg Thr Met Ile Val Ala Asp Tyr Tyr Tyr Gly Leu Asp Val 
1               5                   10                  15  


<210>  44
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  44

Ala Arg Thr Leu Ile Val Ala Asp Tyr Tyr Tyr Gly Leu Asp Val 
1               5                   10                  15  


<210>  45
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  45

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr 
        35                  40                  45              


Ser Ile Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Leu Gln Arg Ser Thr Tyr Pro Tyr Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105         


<210>  46
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  46

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Glu Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Ile Ser Cys Lys Ala Ser Gly Phe Ser Phe Thr Gly Tyr 
            20                  25                  30          


Asn Met Asn Trp Val Lys Gln Ser Asn Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asp Pro Tyr Tyr Gly Val Thr Asp Tyr Asn Leu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Lys Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Leu Leu Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  47
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  47

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Ser Ser Val Ser Tyr Leu 
            20                  25                  30          


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Ser Ile Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Thr Tyr Pro Tyr Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105         


<210>  48
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  48

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Ser Ser Val Ser Tyr Leu 
            20                  25                  30          


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Ser Ile Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Val Tyr Tyr Cys Leu Gln Arg Ser Thr Tyr Pro Tyr Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105         


<210>  49
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  49

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Leu 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Ser Ile Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Val Tyr Tyr Cys Leu Gln Arg Ser Thr Tyr Pro Tyr Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105         


<210>  50
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  50

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Trp Ile Tyr 
        35                  40                  45              


Ser Ile Ser Asn Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Val Tyr Tyr Cys Leu Gln Arg Ser Thr Tyr Pro Tyr Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105         


<210>  51
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  51

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Ser Phe Thr Gly Tyr 
            20                  25                  30          


Asn Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asn Ile Asp Pro Tyr Tyr Gly Val Thr Asp Tyr Asn Leu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Leu Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  52
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  52

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Ser Phe Thr Gly Tyr 
            20                  25                  30          


Asn Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asp Pro Tyr Tyr Gly Val Thr Asp Tyr Asn Leu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Leu Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  53
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  53

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Ser Phe Thr Gly Tyr 
            20                  25                  30          


Asn Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asn Pro Tyr Tyr Gly Val Thr Asp Tyr Asn Leu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Leu Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  54
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  54

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Thr Gly Tyr 
            20                  25                  30          


Asn Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asp Pro Tyr Tyr Gly Val Thr Asp Tyr Asn Leu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Leu Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  55
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  55

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Thr Gly Tyr 
            20                  25                  30          


Asn Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asp Pro Tyr Tyr Gly Val Thr Asp Tyr Asn Leu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Leu Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  56
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  56

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Thr Gly Tyr 
            20                  25                  30          


Asn Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asn Pro Tyr Tyr Gly Val Thr Asp Tyr Asn Leu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Leu Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  57
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  57

Asp Val Val Met Thr Gln Thr Pro Leu Phe Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Glu Asn Ser 
            20                  25                  30          


Asn Gly Asn Thr Phe Leu Ser Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro His Leu Leu Ile Tyr Arg Val Ser Asn Arg Phe Ser Gly Val Leu 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Leu Gln Val 
                85                  90                  95      


Thr His Ala Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  58
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  58

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Arg Tyr 
            20                  25                  30          


Asp Ile Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Asp Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Thr Asp Gly Gly Thr Asn Tyr Asn Ser Ala Phe Lys 
    50                  55                  60                  


Pro Arg Leu Ser Ile Ser Lys Asp Ser Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Val 
                85                  90                  95      


Arg Gly Ala His Tyr Ser Gly Asp Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  59
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  59

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Ser Leu Thr Cys Arg Ala Gly Gln Glu Ile Asn Gly Tyr 
            20                  25                  30          


Leu Ser Trp Leu Gln Gln Lys Pro Asp Gly Thr Ile Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Asp Ser Gly Val Pro Lys Arg Phe Ser Gly 
    50                  55                  60                  


Thr Arg Ser Gly Ser Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Asn Tyr Tyr Cys Leu Gln Tyr Ala Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg 
            100                 105             


<210>  60
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  60

Glu Val Lys Leu Met Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Ser Gly Gly Ala Thr Tyr Tyr Pro Asp Thr Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Ile Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Pro Tyr Tyr Lys Tyr Asp Tyr Gly Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210>  61
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  61

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Arg 
            20                  25                  30          


Asn Gly Asn Ile Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Thr Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Ile His Val Pro Pro Thr Phe Gly Gly Gly Ser Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  62
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  62

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Ile Arg Ile Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Thr Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Ser Tyr Thr Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Phe Ser Leu Glu Ile Ser Val Lys Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asp Asn Leu Arg Lys Glu Asp Met Ala Thr Tyr Phe Cys 
                85                  90                  95      


Val Lys Thr Thr Gly Tyr Phe Met Asp Tyr Trp Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  63
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  63

Asp Ile Gln Met Thr Gln Ile Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Phe Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Arg Tyr Thr Leu Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Arg Leu Glu Ile Lys Arg 
            100                 105             


<210>  64
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  64

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Thr 
1               5                   10                  15      


Ser Met Lys Met Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Ser Tyr 
            20                  25                  30          


Thr Leu His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Thr Pro Tyr Asn Gly Glu Thr His Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Thr Gly Lys Ala Ile Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Asp Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Ala Phe Trp Tyr Gly Asp Ser Phe Ala Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120         


<210>  65
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  65

Ala Ile Gln Leu Thr Gln Ser Pro Ser Ala Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Ser Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Gly Phe 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Gln Pro Gly Lys Ala Pro Lys Leu Leu Met 
        35                  40                  45              


Phe Ala Thr Ser Phe Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Ala Thr Asp Phe Ser Gly Ser Gly Thr Asp Phe Thr Leu 
65                  70                  75                  80  


Thr Ile Asn Asn Leu His Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
                85                  90                  95      


Gln Ser Tyr Thr Thr Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu 
            100                 105                 110         


Ile Lys Arg 
        115 


<210>  66
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  66

Gln Met Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Ser Phe Ser Gly Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Val Ile Pro Ile Phe Gly Ile Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Gly Thr Ile Thr Ala Asp Glu Ser Thr Arg Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Met Ile Val Ala Asp Tyr Tyr Tyr Gly Met Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  67
<211>  80
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  67

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Gly Phe 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Met 
        35                  40                  45              


Phe Ala Thr Ser Phe Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


<210>  68
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  68

Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Thr Thr Pro Leu 
1               5                   10                  15      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
            20                  25              


<210>  69
<211>  80
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  69

Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Gly Phe 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Thr Ser Phe Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Ala Thr Asp Phe Ser Gly Ser Gly Thr Asp Phe Thr Leu 
65                  70                  75                  80  


<210>  70
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  70

Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
1               5                   10                  15      


Gln Ser Tyr Thr Thr Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu 
            20                  25                  30          


Ile Lys Arg 
        35  


<210>  71
<211>  80
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  71

Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Gly Phe 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Thr Ser Phe Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


<210>  72
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  72

Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Thr Thr Pro Leu 
1               5                   10                  15      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
            20                  25              


<210>  73
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  73

Gln Met Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Ser Phe Ser Gly Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Val Ile Pro Ile Phe Gly Ile Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Met Ile Val Ala Asp Tyr Tyr Tyr Gly Met Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  74
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  74

Met Ser Val Pro Thr Gln Val Leu Gly Leu Leu Leu Leu Trp Leu Thr 
1               5                   10                  15      


Asp Ala Arg Cys Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly 
        35                  40                  45              


Ile Ser Gly Phe Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ala Thr Ser Phe Leu Glu Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Ala Thr Asp Phe Ser Gly Ser Gly Thr 
                85                  90                  95      


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
            100                 105                 110         


Tyr Tyr Cys Gln Gln Ser Tyr Thr Thr Pro Leu Thr Phe Gly Gln Gly 
        115                 120                 125             


Thr Arg Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile 
    130                 135                 140                 


Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val 
145                 150                 155                 160 


Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys 
                165                 170                 175     


Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu 
            180                 185                 190         


Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu 
        195                 200                 205             


Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr 
    210                 215                 220                 


His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu 
225                 230                 235                 240 


Cys 
    


<210>  75
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  75
atgagcgtgc ccacccaggt gctgggcctg ctgctgctgt ggctgaccga cgccagatgc       60

gccatccagc tgacccagag ccccagcagc ctgagcgcca gcgtgggcga cagagtgacc      120

atcacctgca gagccagcca gggcatcagc ggcttcctga actggtacca gcagaagccc      180

ggcaaggccc ccaagctgct gatctacgcc accagcttcc tggagagcgg cgtgcccagc      240

agattcagcg gcagcggcag cgccaccgac ttcagcggca gcggcaccga cttcaccctg      300

accatcagca gcctgcagcc cgaggacttc gccacctact actgccagca gagctacacc      360

acccccctga ccttcggcca gggcaccaga ctggagatca agagaaccgt ggccgccccc      420

agcgtgttca tcttcccccc cagcgacgag cagctgaaat ctggaactgc ctctgttgtg      480

tgcctgctga ataacttcta tcccagagag gccaaagtac agtggaaggt ggataacgcc      540

ctccaatcgg gtaactccca ggagagtgtc acagagcagg acagcaagga cagcacctac      600

agcctcagca gcaccctgac gctgagcaaa gcagactacg agaaacacaa agtctacgcc      660

tgcgaagtca cccatcaggg cctgagttcg cccgtcacaa agagcttcaa caggggagag      720

tgttga                                                                 726


<210>  76
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  76

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Gln Met Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Ser Phe 
        35                  40                  45              


Ser Gly Tyr Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Gly Val Ile Pro Ile Phe Gly Ile Ala Asn Tyr Ala 
65                  70                  75                  80  


Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Thr Leu Ile Val Ala Asp Tyr Tyr Tyr Gly Leu 
        115                 120                 125             


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser 
145                 150                 155                 160 


Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys 
    210                 215                 220                 


Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
225                 230                 235                 240 


Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Leu Gly Lys 
465             


<210>  77
<211>  1407
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  77
atggagtgga gctgggtgtt cctgttcttc ctgagcgtga ccaccggcgt gcacagccag       60

atgcagctgg tgcagagcgg cgccgaggtg aagaagcccg gcagcagcgt gaaggtgagc      120

tgcaaggcca gcggcggcag cttcagcggc tacgccatca gctgggtgag acaggccccc      180

ggccagggcc tggagtggat gggcggcgtg atccccatct tcggcatcgc caactacgcc      240

cagaagttcc agggcagagt gaccatcacc gccgacgaga gcaccagcac cgcctacatg      300

gagctgagca gcctgagaag cgaggacacc gccgtgtact actgcgccag aaccctgatc      360

gtggccgact actactacgg cctggacgtg tggggccagg gcaccaccgt gaccgtgagc      420

agcgccagca ccaagggccc cagcgtgttc cccctggccc cctgcagcag atccacctcc      480

gagagcacag ccgccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      540

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc      600

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacgaag      660

acctacacct gcaacgtaga tcacaagccc agcaacacca aggtggacaa gagagttgag      720

tccaaatatg gtcccccatg cccaccatgc ccagcacctg aggccgcagg gggaccatca      780

gtcttcctgt tccccccaaa acccaaggac actctcatga tctcccggac ccctgaggtc      840

acgtgcgtgg tggtggacgt gagccaggaa gaccccgagg tccagttcaa ctggtacgtg      900

gatggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagtt caacagcacg      960

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaacgg caaggagtac     1020

aagtgcaagg tctccaacaa aggcctcccg tcctccatcg agaaaaccat ctccaaagcc     1080

aaagggcagc cccgagagcc acaggtgtac accctgcccc catcccagga ggagatgacc     1140

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct accccagcga catcgccgtg     1200

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1260

tccgacggct ccttcttcct ctacagcagg ctaaccgtgg acaagagcag gtggcaggag     1320

gggaatgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacacagaag     1380

agcctctccc tgtctctggg taaatga                                         1407


<210>  78
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  78

Met Ala Trp Ala Leu Leu Leu Leu Thr Leu Leu Thr Gln Gly Thr Gly 
1               5                   10                  15      


Ser Trp Ala Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu 
            20                  25                  30          


Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val 
        35                  40                  45              


Ser Tyr Met His Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu 
    50                  55                  60                  


Trp Ile Tyr Ser Ile Ser Asn Leu Ala Ser Gly Ile Pro Ala Arg Phe 
65                  70                  75                  80  


Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu 
                85                  90                  95      


Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Leu Gln Arg Ser Thr Tyr 
            100                 105                 110         


Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val 
        115                 120                 125             


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
    130                 135                 140                 


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
145                 150                 155                 160 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
                165                 170                 175     


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
            180                 185                 190         


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
        195                 200                 205             


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
    210                 215                 220                 


Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230         


<210>  79
<211>  696
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  79
atggcttggg ctctgctgct gctgaccctg ctgactcaag gcacaggctc ttgggctgat       60

attgtgctga cccagtctcc tgccacactg tctttgagcc ctggcgagag agctaccctg      120

tcctgctctg cctcctcctc cgtgtcttac atgcactggt tccagcagaa gcccggccag      180

gctcctagac tgtggatcta ctccatctcc aacctggcca gcggcatccc tgccagattt      240

tctggctctg gaagcggcac cgactatacc ctgaccatca gctccctgga acctgaggac      300

ttcgccgtgt actactgcct gcagcggtcc acctatcctt acacctttgg ccagggcacc      360

aagctggaaa tcaagcggac agtggccgct ccttccgtgt tcatcttccc accttccgac      420

gagcagctga agtctggcac agcctctgtc gtgtgcctgc tgaacaactt ctaccctcgg      480

gaagccaagg tgcagtggaa ggtggacaat gccctgcagt ccggcaactc ccaagagtcc      540

gtgaccgagc aggactccaa ggactctacc tacagcctgt cctccacact gaccctgtcc      600

aaggccgact acgagaagca caaggtgtac gcctgcgaag tgacccatca gggcctgtct      660

agccctgtga ccaagtcttt caaccggggc gagtgt                                696


<210>  80
<211>  460
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  80

Met Ala Trp Ala Leu Leu Leu Leu Thr Leu Leu Thr Gln Gly Thr Gly 
1               5                   10                  15      


Ser Trp Ala Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Ser Phe 
        35                  40                  45              


Thr Gly Tyr Asn Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Asn Ile Asp Pro Tyr Tyr Gly Val Thr Asp Tyr Asn 
65                  70                  75                  80  


Leu Lys Phe Lys Gly Lys Ala Thr Ile Thr Ala Asp Lys Ser Thr Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Ser Leu Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
        115                 120                 125             


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
    130                 135                 140                 


Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys 
145                 150                 155                 160 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
                165                 170                 175     


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
            180                 185                 190         


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
        195                 200                 205             


Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn 
    210                 215                 220                 


Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro 
225                 230                 235                 240 


Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe 
                245                 250                 255     


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
            260                 265                 270         


Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 
        275                 280                 285             


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
    290                 295                 300                 


Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
305                 310                 315                 320 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
                325                 330                 335     


Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
            340                 345                 350         


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln 
        355                 360                 365             


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
    370                 375                 380                 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
385                 390                 395                 400 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
                405                 410                 415     


Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 
            420                 425                 430         


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
        435                 440                 445             


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
    450                 455                 460 


<210>  81
<211>  1383
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  81
atggcttggg ctctgctgct gctgaccctg ctgacacaag gcacaggctc ttgggctgaa       60

gtgcagctgg ttcagtctgg cgccgaagtg aagaaacctg gctcctccgt gaaggtgtcc      120

tgcaaggcct ctggcttctc cttcaccggc tacaacatga actgggtccg acaggctcct      180

ggacagggac tcgagtggat cggcaacatc gacccttact acggcgtgac cgactacaac      240

ctgaagttca agggcaaagc caccatcacc gccgacaagt ctacctccac cgcctacatg      300

gaactgtcca gcctgagatc tgaggacacc gccgtgtact actgcgcttc cctgctgctg      360

gattattggg gccagggcac actggtcacc gtgtcctctg cttctaccaa gggacccagc      420

gtgttccctc tggctccttg ctccagatct acctccgagt ctaccgctgc tctgggctgc      480

ctggtcaagg actactttcc tgagcctgtg accgtgtctt ggaactctgg cgctctgaca      540

tccggcgtgc acacctttcc agctgtgctg caatcctccg gcctgtactc tctgtcctcc      600

gtcgtgaccg tgccttctag ctctctgggc accaagacct acacctgtaa tgtggaccac      660

aagccttcca acaccaaggt ggacaagcgc gtggaatcta agtacggccc tccttgtcct      720

ccatgtcctg ctccagaagc tgctggcggc ccttccgtgt ttctgttccc tccaaagcct      780

aaggacaccc tgatgatctc tcggacccct gaagtgacct gcgtggtggt cgatgtgtcc      840

caagaggatc ccgaggtgca gttcaattgg tacgtggacg gcgtggaagt gcacaacgcc      900

aagaccaagc ctagagagga acagttcaac tccacctaca gagtggtgtc cgtgctgaca      960

gtgctgcacc aggattggct gaacggcaaa gagtacaagt gcaaggtgtc caacaagggc     1020

ctgccttcca gcatcgaaaa gaccatctcc aaggccaagg gccagcctag ggaaccccag     1080

gtttacaccc tgcctccaag ccaagaggaa atgaccaaga accaggtgtc cctgacctgc     1140

ctcgtgaagg gcttctaccc ttccgatatc gccgtggaat gggagagcaa tggccagcca     1200

gagaacaact acaagacaac ccctcctgtg ctggactccg acggcagctt cttcctgtat     1260

tctcggctga ccgtggacaa gtccagatgg caagagggca acgtgttctc ctgctccgtg     1320

atgcacgagg ccctgcacaa tcactacacc cagaagtctc tgtccctgag tctgggcaag     1380

tga                                                                   1383


<210>  82
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  82

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Gly 
            20                  25                  30      


<210>  83
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  83

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala 
1               5                   10                  15      


<210>  84
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  84

Gly Gly Ser Gly Gly Gly Gly Ser 
1               5               


<210>  85
<211>  161
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  85

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Gly Gly 
            20                  25                  30          


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu 
        35                  40                  45              


Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser 
    50                  55                  60                  


Val Lys Val Ser Cys Lys Ala Ser Gly Phe Ser Phe Thr Gly Tyr Asn 
65                  70                  75                  80  


Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly 
                85                  90                  95      


Asn Ile Asp Pro Tyr Tyr Gly Val Thr Asp Tyr Asn Leu Lys Phe Lys 
            100                 105                 110         


Gly Lys Ala Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met 
        115                 120                 125             


Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
    130                 135                 140                 


Ser Leu Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
145                 150                 155                 160 


Ser 
    


<210>  86
<211>  146
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  86

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Gly Gly 
            20                  25                  30          


Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro Ala 
        35                  40                  45              


Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Ser Ala 
    50                  55                  60                  


Ser Ser Ser Val Ser Tyr Met His Trp Phe Gln Gln Lys Pro Gly Gln 
65                  70                  75                  80  


Ala Pro Arg Leu Trp Ile Tyr Ser Ile Ser Asn Leu Ala Ser Gly Ile 
                85                  90                  95      


Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr 
            100                 105                 110         


Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Leu Gln 
        115                 120                 125             


Arg Ser Thr Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
    130                 135                 140                 


Lys Arg 
145     


<210>  87
<211>  507
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  87

Met Ala Trp Ala Leu Leu Leu Leu Thr Leu Leu Thr Gln Gly Thr Gly 
1               5                   10                  15      


Ser Trp Ala His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr 
            20                  25                  30          


Leu Glu Glu Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
        35                  40                  45              


Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    50                  55                  60                  


Ser Ala Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro 
65                  70                  75                  80  


Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Ser Phe Thr 
                85                  90                  95      


Gly Tyr Asn Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu 
            100                 105                 110         


Trp Ile Gly Asn Ile Asp Pro Tyr Tyr Gly Val Thr Asp Tyr Asn Leu 
        115                 120                 125             


Lys Phe Lys Gly Lys Ala Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr 
    130                 135                 140                 


Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr 
145                 150                 155                 160 


Tyr Cys Ala Ser Leu Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val 
                165                 170                 175     


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
            180                 185                 190         


Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu 
        195                 200                 205             


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
    210                 215                 220                 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
225                 230                 235                 240 


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
                245                 250                 255     


Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr 
            260                 265                 270         


Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro 
        275                 280                 285             


Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro 
    290                 295                 300                 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
305                 310                 315                 320 


Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn 
                325                 330                 335     


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
            340                 345                 350         


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
        355                 360                 365             


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
    370                 375                 380                 


Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
385                 390                 395                 400 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu 
                405                 410                 415     


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            420                 425                 430         


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        435                 440                 445             


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    450                 455                 460                 


Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly 
465                 470                 475                 480 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                485                 490                 495     


Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
            500                 505         


<210>  88
<211>  1524
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  88
atggcttggg ctctgctgct gctgaccctg ctgacacaag gcacaggctc ttgggctcat       60

ggcgagggca cctttacctc cgacgtgtcc tcctacctgg aagaacaggc cgccaaagag      120

tttatcgcct ggctggtcaa aggtggcggc ggaggcggag gaagcggtgg cggaggttca      180

ggtggtggtg gatctgctga agtgcagctg gttcagtctg gcgccgaagt gaagaaacct      240

ggctcctccg tgaaggtgtc ctgcaaggcc tctggcttct ccttcaccgg ctacaacatg      300

aactgggtcc gacaggctcc tggacaggga ctcgagtgga tcggcaacat cgacccttac      360

tacggcgtga ccgactacaa cctgaagttc aagggcaaag ccaccatcac cgccgacaag      420

tctacctcca ccgcctacat ggaactgtcc agcctgagat ctgaggacac cgccgtgtac      480

tactgcgctt ccctgctgct ggattattgg ggccagggca cactggtcac cgtgtcctct      540

gcttctacca agggacccag cgtgttccct ctggctcctt gctccagatc tacctccgag      600

tctaccgctg ctctgggctg cctggtcaag gactactttc ctgagcctgt gaccgtgtct      660

tggaactctg gcgctctgac atccggcgtg cacacctttc cagctgtgct gcaatcctcc      720

ggcctgtact ctctgtcctc cgtcgtgacc gtgccttcta gctctctggg caccaagacc      780

tacacctgta atgtggacca caagccttcc aacaccaagg tggacaagcg cgtggaatct      840

aagtacggcc ctccttgtcc tccatgtcct gctccagaag ctgctggcgg cccttccgtg      900

tttctgttcc ctccaaagcc taaggacacc ctgatgatct ctcggacccc tgaagtgacc      960

tgcgtggtgg tcgatgtgtc ccaagaggat cccgaggtgc agttcaattg gtacgtggac     1020

ggcgtggaag tgcacaacgc caagaccaag cctagagagg aacagttcaa ctccacctac     1080

agagtggtgt ccgtgctgac agtgctgcac caggattggc tgaacggcaa agagtacaag     1140

tgcaaggtgt ccaacaaggg cctgccttcc agcatcgaaa agaccatctc caaggccaag     1200

ggccagccta gggaacccca ggtttacacc ctgcctccaa gccaagagga aatgaccaag     1260

aaccaggtgt ccctgacctg cctcgtgaag ggcttctacc cttccgatat cgccgtggaa     1320

tgggagagca atggccagcc agagaacaac tacaagacaa cccctcctgt gctggactcc     1380

gacggcagct tcttcctgta ttctcggctg accgtggaca agtccagatg gcaagagggc     1440

aacgtgttct cctgctccgt gatgcacgag gccctgcaca atcactacac ccagaagtct     1500

ctgtccctga gtctgggcaa gtga                                            1524


<210>  89
<211>  271
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  89

Met Ala Trp Ala Leu Leu Leu Leu Thr Leu Leu Thr Gln Gly Thr Gly 
1               5                   10                  15      


Ser Trp Ala His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr 
            20                  25                  30          


Leu Glu Glu Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
        35                  40                  45              


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln 
    50                  55                  60                  


Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser 
65                  70                  75                  80  


Cys Ser Ala Ser Ser Ser Val Ser Tyr Met His Trp Phe Gln Gln Lys 
                85                  90                  95      


Pro Gly Gln Ala Pro Arg Leu Trp Ile Tyr Ser Ile Ser Asn Leu Ala 
            100                 105                 110         


Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
        115                 120                 125             


Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr 
    130                 135                 140                 


Cys Leu Gln Arg Ser Thr Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys 
145                 150                 155                 160 


Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
                165                 170                 175     


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
            180                 185                 190         


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
        195                 200                 205             


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
    210                 215                 220                 


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
225                 230                 235                 240 


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
                245                 250                 255     


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            260                 265                 270     


<210>  90
<211>  813
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  90
atggcttggg ctctgctgct gctgaccctg ctgactcaag gcacaggctc ttgggctcat       60

ggcgagggca cctttacctc cgacgtgtcc tcctacctgg aagaacaggc cgccaaagag      120

tttatcgcct ggctggtcaa aggtggcggc ggaggatctg gcggaggcgg atctgatatt      180

gtgctgaccc agtctcctgc cacactgtct ttgagccctg gcgagagagc taccctgtcc      240

tgctctgcct cctcctccgt gtcttacatg cactggttcc agcagaagcc cggccaggct      300

cctagactgt ggatctactc catctccaac ctggccagcg gcatccctgc cagattttct      360

ggctctggaa gcggcaccga ctataccctg accatcagct ccctggaacc tgaggacttc      420

gccgtgtact actgcctgca gcggtccacc tatccttaca cctttggcca gggcaccaag      480

ctggaaatca agcggacagt ggccgctcct tccgtgttca tcttcccacc ttccgacgag      540

cagctgaagt ctggcacagc ctctgtcgtg tgcctgctga acaacttcta ccctcgggaa      600

gccaaggtgc agtggaaggt ggacaatgcc ctgcagtccg gcaactccca agagtccgtg      660

accgagcagg actccaagga ctctacctac agcctgtcct ccacactgac cctgtccaag      720

gccgactacg agaagcacaa ggtgtacgcc tgcgaagtga cccatcaggg cctgtctagc      780

cctgtgacca agtctttcaa ccggggcgag tgt                                   813


<210>  91
<211>  466
<212>  PRT
<213>  Homo sapiens

<400>  91

Met Thr Thr Ser Pro Ile Leu Gln Leu Leu Leu Arg Leu Ser Leu Cys 
1               5                   10                  15      


Gly Leu Leu Leu Gln Arg Ala Glu Thr Gly Ser Lys Gly Gln Thr Ala 
            20                  25                  30          


Gly Glu Leu Tyr Gln Arg Trp Glu Arg Tyr Arg Arg Glu Cys Gln Glu 
        35                  40                  45              


Thr Leu Ala Ala Ala Glu Pro Pro Ser Gly Leu Ala Cys Asn Gly Ser 
    50                  55                  60                  


Phe Asp Met Tyr Val Cys Trp Asp Tyr Ala Ala Pro Asn Ala Thr Ala 
65                  70                  75                  80  


Arg Ala Ser Cys Pro Trp Tyr Leu Pro Trp His His His Val Ala Ala 
                85                  90                  95      


Gly Phe Val Leu Arg Gln Cys Gly Ser Asp Gly Gln Trp Gly Leu Trp 
            100                 105                 110         


Arg Asp His Thr Gln Cys Glu Asn Pro Glu Lys Asn Glu Ala Phe Leu 
        115                 120                 125             


Asp Gln Arg Leu Ile Leu Glu Arg Leu Gln Val Met Tyr Thr Val Gly 
    130                 135                 140                 


Tyr Ser Leu Ser Leu Ala Thr Leu Leu Leu Ala Leu Leu Ile Leu Ser 
145                 150                 155                 160 


Leu Phe Arg Arg Leu His Cys Thr Arg Asn Tyr Ile His Ile Asn Leu 
                165                 170                 175     


Phe Thr Ser Phe Met Leu Arg Ala Ala Ala Ile Leu Ser Arg Asp Arg 
            180                 185                 190         


Leu Leu Pro Arg Pro Gly Pro Tyr Leu Gly Asp Gln Ala Leu Ala Leu 
        195                 200                 205             


Trp Asn Gln Ala Leu Ala Ala Cys Arg Thr Ala Gln Ile Val Thr Gln 
    210                 215                 220                 


Tyr Cys Val Gly Ala Asn Tyr Thr Trp Leu Leu Val Glu Gly Val Tyr 
225                 230                 235                 240 


Leu His Ser Leu Leu Val Leu Val Gly Gly Ser Glu Glu Gly His Phe 
                245                 250                 255     


Arg Tyr Tyr Leu Leu Leu Gly Trp Gly Ala Pro Ala Leu Phe Val Ile 
            260                 265                 270         


Pro Trp Val Ile Val Arg Tyr Leu Tyr Glu Asn Thr Gln Cys Trp Glu 
        275                 280                 285             


Arg Asn Glu Val Lys Ala Ile Trp Trp Ile Ile Arg Thr Pro Ile Leu 
    290                 295                 300                 


Met Thr Ile Leu Ile Asn Phe Leu Ile Phe Ile Arg Ile Leu Gly Ile 
305                 310                 315                 320 


Leu Leu Ser Lys Leu Arg Thr Arg Gln Met Arg Cys Arg Asp Tyr Arg 
                325                 330                 335     


Leu Arg Leu Ala Arg Ser Thr Leu Thr Leu Val Pro Leu Leu Gly Val 
            340                 345                 350         


His Glu Val Val Phe Ala Pro Val Thr Glu Glu Gln Ala Arg Gly Ala 
        355                 360                 365             


Leu Arg Phe Ala Lys Leu Gly Phe Glu Ile Phe Leu Ser Ser Phe Gln 
    370                 375                 380                 


Gly Phe Leu Val Ser Val Leu Tyr Cys Phe Ile Asn Lys Glu Val Gln 
385                 390                 395                 400 


Ser Glu Ile Arg Arg Gly Trp His His Cys Arg Leu Arg Arg Ser Leu 
                405                 410                 415     


Gly Glu Glu Gln Arg Gln Leu Pro Glu Arg Ala Phe Arg Ala Leu Pro 
            420                 425                 430         


Ser Gly Ser Gly Pro Gly Glu Val Pro Thr Ser Arg Gly Leu Ser Ser 
        435                 440                 445             


Gly Thr Leu Pro Gly Pro Gly Asn Glu Ala Ser Arg Glu Leu Glu Ser 
    450                 455                 460                 


Tyr Cys 
465     


<210>  92
<211>  430
<212>  PRT
<213>  Synthetic

<400>  92

Met Thr Thr Ser Pro Ile Leu Gln Leu Leu Leu Arg Leu Ser Leu Cys 
1               5                   10                  15      


Gly Leu Leu Leu Gln Arg Ala Glu Thr Gly Ser Lys Gly Gln Thr Ala 
            20                  25                  30          


Gly Glu Leu Tyr Gln Arg Trp Glu Arg Tyr Arg Arg Glu Cys Gln Glu 
        35                  40                  45              


Thr Leu Ala Ala Ala Glu Pro Pro Ser Val Ala Ala Gly Phe Val Leu 
    50                  55                  60                  


Arg Gln Cys Gly Ser Asp Gly Gln Trp Gly Leu Trp Arg Asp His Thr 
65                  70                  75                  80  


Gln Cys Glu Asn Pro Glu Lys Asn Glu Ala Phe Leu Asp Gln Arg Leu 
                85                  90                  95      


Ile Leu Glu Arg Leu Gln Val Met Tyr Thr Val Gly Tyr Ser Leu Ser 
            100                 105                 110         


Leu Ala Thr Leu Leu Leu Ala Leu Leu Ile Leu Ser Leu Phe Arg Arg 
        115                 120                 125             


Leu His Cys Thr Arg Asn Tyr Ile His Ile Asn Leu Phe Thr Ser Phe 
    130                 135                 140                 


Met Leu Arg Ala Ala Ala Ile Leu Ser Arg Asp Arg Leu Leu Pro Arg 
145                 150                 155                 160 


Pro Gly Pro Tyr Leu Gly Asp Gln Ala Leu Ala Leu Trp Asn Gln Ala 
                165                 170                 175     


Leu Ala Ala Cys Arg Thr Ala Gln Ile Val Thr Gln Tyr Cys Val Gly 
            180                 185                 190         


Ala Asn Tyr Thr Trp Leu Leu Val Glu Gly Val Tyr Leu His Ser Leu 
        195                 200                 205             


Leu Val Leu Val Gly Gly Ser Glu Glu Gly His Phe Arg Tyr Tyr Leu 
    210                 215                 220                 


Leu Leu Gly Trp Gly Ala Pro Ala Leu Phe Val Ile Pro Trp Val Ile 
225                 230                 235                 240 


Val Arg Tyr Leu Tyr Glu Asn Thr Gln Cys Trp Glu Arg Asn Glu Val 
                245                 250                 255     


Lys Ala Ile Trp Trp Ile Ile Arg Thr Pro Ile Leu Met Thr Ile Leu 
            260                 265                 270         


Ile Asn Phe Leu Ile Phe Ile Arg Ile Leu Gly Ile Leu Leu Ser Lys 
        275                 280                 285             


Leu Arg Thr Arg Gln Met Arg Cys Arg Asp Tyr Arg Leu Arg Leu Ala 
    290                 295                 300                 


Arg Ser Thr Leu Thr Leu Val Pro Leu Leu Gly Val His Glu Val Val 
305                 310                 315                 320 


Phe Ala Pro Val Thr Glu Glu Gln Ala Arg Gly Ala Leu Arg Phe Ala 
                325                 330                 335     


Lys Leu Gly Phe Glu Ile Phe Leu Ser Ser Phe Gln Gly Phe Leu Val 
            340                 345                 350         


Ser Val Leu Tyr Cys Phe Ile Asn Lys Glu Val Gln Ser Glu Ile Arg 
        355                 360                 365             


Arg Gly Trp His His Cys Arg Leu Arg Arg Ser Leu Gly Glu Glu Gln 
    370                 375                 380                 


Arg Gln Leu Pro Glu Arg Ala Phe Arg Ala Leu Pro Ser Gly Ser Gly 
385                 390                 395                 400 


Pro Gly Glu Val Pro Thr Ser Arg Gly Leu Ser Ser Gly Thr Leu Pro 
                405                 410                 415     


Gly Pro Gly Asn Glu Ala Ser Arg Glu Leu Glu Ser Tyr Cys 
            420                 425                 430 


<210>  93
<211>  443
<212>  PRT
<213>  Synthetic

<400>  93

Ala Ala Ala Glu Pro Pro Ser Gly Leu Ala Cys Asn Gly Ser Phe Asp 
1               5                   10                  15      


Met Tyr Val Cys Trp Asp Tyr Ala Ala Pro Asn Ala Thr Ala Arg Ala 
            20                  25                  30          


Ser Cys Pro Trp Tyr Leu Pro Trp His His His Val Ala Ala Gly Phe 
        35                  40                  45              


Val Leu Arg Gln Cys Gly Ser Asp Gly Gln Trp Gly Leu Trp Arg Asp 
    50                  55                  60                  


His Thr Gln Cys Glu Asn Pro Glu Lys Asn Glu Ala Phe Leu Asp Gln 
65                  70                  75                  80  


Arg Leu Ile Leu Glu Arg Leu Gln Val Met Tyr Thr Val Gly Tyr Ser 
                85                  90                  95      


Leu Ser Leu Ala Thr Leu Leu Leu Ala Leu Leu Ile Leu Ser Leu Phe 
            100                 105                 110         


Arg Arg Leu His Cys Thr Arg Asn Tyr Ile His Ile Asn Leu Phe Thr 
        115                 120                 125             


Ser Phe Met Leu Arg Ala Ala Ala Ile Leu Ser Arg Asp Arg Leu Leu 
    130                 135                 140                 


Pro Arg Pro Gly Pro Tyr Leu Gly Asp Gln Ala Leu Ala Leu Trp Asn 
145                 150                 155                 160 


Gln Ala Leu Ala Ala Cys Arg Thr Ala Gln Ile Val Thr Gln Tyr Cys 
                165                 170                 175     


Val Gly Ala Asn Tyr Thr Trp Leu Leu Val Glu Gly Val Tyr Leu His 
            180                 185                 190         


Ser Leu Leu Val Leu Val Gly Gly Ser Glu Glu Gly His Phe Arg Tyr 
        195                 200                 205             


Tyr Leu Leu Leu Gly Trp Gly Ala Pro Ala Leu Phe Val Ile Pro Trp 
    210                 215                 220                 


Val Ile Val Arg Tyr Leu Tyr Glu Asn Thr Gln Cys Trp Glu Arg Asn 
225                 230                 235                 240 


Glu Val Lys Ala Ile Trp Trp Ile Ile Arg Thr Pro Ile Leu Met Thr 
                245                 250                 255     


Ile Leu Ile Asn Phe Leu Ile Phe Ile Arg Ile Leu Gly Ile Leu Leu 
            260                 265                 270         


Ser Lys Leu Arg Thr Arg Gln Met Arg Cys Arg Asp Tyr Arg Leu Arg 
        275                 280                 285             


Leu Ala Arg Ser Thr Leu Thr Leu Val Pro Leu Leu Gly Val His Glu 
    290                 295                 300                 


Val Val Phe Ala Pro Val Thr Glu Glu Gln Ala Arg Gly Ala Leu Arg 
305                 310                 315                 320 


Phe Ala Lys Leu Gly Phe Glu Ile Phe Leu Ser Ser Phe Gln Gly Phe 
                325                 330                 335     


Leu Val Ser Val Leu Tyr Cys Phe Ile Asn Lys Glu Val Gly Arg Asp 
            340                 345                 350         


Pro Ala Ala Ala Pro Ala Leu Trp Arg Arg Arg Gly Thr Ala Pro Pro 
        355                 360                 365             


Leu Ser Ala Ile Val Ser Gln Val Gln Ser Glu Ile Arg Arg Gly Trp 
    370                 375                 380                 


His His Cys Arg Leu Arg Arg Ser Leu Gly Glu Glu Gln Arg Gln Leu 
385                 390                 395                 400 


Pro Glu Arg Ala Phe Arg Ala Leu Pro Ser Gly Ser Gly Pro Gly Glu 
                405                 410                 415     


Val Pro Thr Ser Arg Gly Leu Ser Ser Gly Thr Leu Pro Gly Pro Gly 
            420                 425                 430         


Asn Glu Ala Ser Arg Glu Leu Glu Ser Tyr Cys 
        435                 440             


<210>  94
<211>  460
<212>  PRT
<213>  Mus musculus

<400>  94

Met Pro Leu Arg Leu Leu Leu Leu Leu Leu Trp Leu Trp Gly Leu Gln 
1               5                   10                  15      


Trp Ala Glu Thr Asp Ser Glu Gly Gln Thr Thr Thr Gly Glu Leu Tyr 
            20                  25                  30          


Gln Arg Trp Glu His Tyr Gly Gln Glu Cys Gln Lys Met Leu Glu Thr 
        35                  40                  45              


Thr Glu Pro Pro Ser Gly Leu Ala Cys Asn Gly Ser Phe Asp Met Tyr 
    50                  55                  60                  


Ala Cys Trp Asn Tyr Thr Ala Ala Asn Thr Thr Ala Arg Val Ser Cys 
65                  70                  75                  80  


Pro Trp Tyr Leu Pro Trp Phe Arg Gln Val Ser Ala Gly Phe Val Phe 
                85                  90                  95      


Arg Gln Cys Gly Ser Asp Gly Gln Trp Gly Ser Trp Arg Asp His Thr 
            100                 105                 110         


Gln Cys Glu Asn Pro Glu Lys Asn Gly Ala Phe Gln Asp Gln Thr Leu 
        115                 120                 125             


Ile Leu Glu Arg Leu Gln Ile Met Tyr Thr Val Gly Tyr Ser Leu Ser 
    130                 135                 140                 


Leu Thr Thr Leu Leu Leu Ala Leu Leu Ile Leu Ser Leu Phe Arg Arg 
145                 150                 155                 160 


Leu His Cys Thr Arg Asn Tyr Ile His Met Asn Leu Phe Thr Ser Phe 
                165                 170                 175     


Met Leu Arg Ala Ala Ala Ile Leu Thr Arg Asp Gln Leu Leu Pro Pro 
            180                 185                 190         


Leu Gly Pro Tyr Thr Gly Asp Gln Ala Pro Thr Pro Trp Asn Gln Ala 
        195                 200                 205             


Leu Ala Ala Cys Arg Thr Ala Gln Ile Met Thr Gln Tyr Cys Val Gly 
    210                 215                 220                 


Ala Asn Tyr Thr Trp Leu Leu Val Glu Gly Val Tyr Leu His His Leu 
225                 230                 235                 240 


Leu Val Ile Val Gly Arg Ser Glu Lys Gly His Phe Arg Cys Tyr Leu 
                245                 250                 255     


Leu Leu Gly Trp Gly Ala Pro Ala Leu Phe Val Ile Pro Trp Val Ile 
            260                 265                 270         


Val Arg Tyr Leu Arg Glu Asn Thr Gln Cys Trp Glu Arg Asn Glu Val 
        275                 280                 285             


Lys Ala Ile Trp Trp Ile Ile Arg Thr Pro Ile Leu Ile Thr Ile Leu 
    290                 295                 300                 


Ile Asn Phe Leu Ile Phe Ile Arg Ile Leu Gly Ile Leu Val Ser Lys 
305                 310                 315                 320 


Leu Arg Thr Arg Gln Met Arg Cys Pro Asp Tyr Arg Leu Arg Leu Ala 
                325                 330                 335     


Arg Ser Thr Leu Thr Leu Val Pro Leu Leu Gly Val His Glu Val Val 
            340                 345                 350         


Phe Ala Pro Val Thr Glu Glu Gln Val Glu Gly Ser Leu Arg Phe Ala 
        355                 360                 365             


Lys Leu Ala Phe Glu Ile Phe Leu Ser Ser Phe Gln Gly Phe Leu Val 
    370                 375                 380                 


Ser Val Leu Tyr Cys Phe Ile Asn Lys Glu Val Gln Ser Glu Ile Arg 
385                 390                 395                 400 


Gln Gly Trp Arg His Arg Arg Leu Arg Leu Ser Leu Gln Glu Gln Arg 
                405                 410                 415     


Pro Arg Pro His Gln Glu Leu Ala Pro Arg Ala Val Pro Leu Ser Ser 
            420                 425                 430         


Ala Cys Arg Glu Ala Ala Val Gly Asn Ala Leu Pro Ser Gly Met Leu 
        435                 440                 445             


His Val Pro Gly Asp Glu Val Leu Glu Ser Tyr Cys 
    450                 455                 460 


<210>  95
<211>  230
<212>  PRT
<213>  Mus musculus

<400>  95

Met Pro Leu Arg Leu Leu Leu Leu Leu Leu Trp Leu Trp Gly Leu Gln 
1               5                   10                  15      


Trp Ala Glu Thr Asp Ser Glu Gly Gln Thr Thr Thr Gly Glu Leu Tyr 
            20                  25                  30          


Gln Arg Trp Glu His Tyr Gly Gln Glu Cys Gln Lys Met Leu Glu Thr 
        35                  40                  45              


Thr Glu Pro Pro Ser Gly Leu Ala Cys Asn Gly Ser Phe Asp Met Tyr 
    50                  55                  60                  


Ala Cys Trp Asn Tyr Thr Ala Ala Asn Thr Thr Ala Arg Val Ser Cys 
65                  70                  75                  80  


Pro Trp Tyr Leu Pro Trp Phe Arg Gln Val Ser Ala Gly Phe Val Phe 
                85                  90                  95      


Arg Gln Cys Gly Ser Asp Gly Gln Trp Gly Ser Trp Arg Asp His Thr 
            100                 105                 110         


Gln Cys Glu Asn Pro Glu Lys Asn Gly Ala Phe Gln Asp Gln Thr Leu 
        115                 120                 125             


Ile Leu Glu Arg Leu Gln Ile Met Tyr Thr Val Gly Tyr Ser Leu Ser 
    130                 135                 140                 


Leu Thr Thr Leu Leu Leu Ala Leu Leu Ile Leu Ser Leu Phe Arg Arg 
145                 150                 155                 160 


Leu His Cys Thr Arg Asn Tyr Ile His Met Asn Leu Phe Thr Ser Phe 
                165                 170                 175     


Met Leu Arg Ala Ala Ala Ile Leu Thr Arg Asp Gln Leu Leu Pro Pro 
            180                 185                 190         


Leu Gly Pro Tyr Thr Gly Asp Gln Ala Pro Thr Pro Trp Asn Gln Val 
        195                 200                 205             


Leu His Arg Leu Leu Pro Gly Gly Thr Lys Thr Phe Pro Ile Tyr Phe 
    210                 215                 220                 


Arg Thr Phe Pro His His 
225                 230 


<210>  96
<211>  127
<212>  PRT
<213>  Homo sapiens

<400>  96

Met Thr Thr Ser Pro Ile Leu Gln Leu Leu Leu Arg Leu Ser Leu Cys 
1               5                   10                  15      


Gly Leu Leu Leu Gln Arg Ala Glu Thr Gly Ser Lys Gly Gln Thr Ala 
            20                  25                  30          


Gly Glu Leu Tyr Gln Arg Trp Glu Arg Tyr Arg Arg Glu Cys Gln Glu 
        35                  40                  45              


Thr Leu Ala Ala Ala Glu Pro Pro Ser Gly Leu Ala Cys Asn Gly Ser 
    50                  55                  60                  


Phe Asp Met Tyr Val Cys Trp Asp Tyr Ala Ala Pro Asn Ala Thr Ala 
65                  70                  75                  80  


Arg Ala Ser Cys Pro Trp Tyr Leu Pro Trp His His His Val Ala Ala 
                85                  90                  95      


Gly Phe Val Leu Arg Gln Cys Gly Ser Asp Gly Gln Trp Gly Leu Trp 
            100                 105                 110         


Arg Asp His Thr Gln Cys Glu Asn Pro Glu Lys Asn Glu Ala Phe 
        115                 120                 125         


