                         SEQUENCE LISTING

<110>  Chimera Bioengineering, Inc.
 
<120>  Compositions and Methods for Activating NK cells

<130>  CBIO.0056

<160>  25    

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  AU repeat element

<400>  1
auuua                                                                    5


<210>  2
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  AU rich element

<400>  2
auuuauuuau uua                                                          13


<210>  3
<211>  5
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  GU rich repeat element

<400>  3
uuguu                                                                    5


<210>  4
<211>  7
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  GU rich repeat element

<400>  4
uggggau                                                                  7


<210>  5
<211>  5
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  U rich repeat element

<400>  5
guuug                                                                    5


<210>  6
<211>  7
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  GU rich element

<400>  6
uuuguuu                                                                  7


<210>  7
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  U rich element


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  n is a, c, g, or u

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  n is a, c, g, or u

<400>  7
nnuunnuuu                                                                9


<210>  8
<211>  7
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  U rich element

<400>  8
uuuauuu                                                                  7


<210>  9
<211>  7
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  U rich element

<400>  9
uuuuuuu                                                                  7


<210>  10
<211>  5
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RDE element

<400>  10
uuaga                                                                    5


<210>  11
<211>  5
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RDE element

<400>  11
aguuu                                                                    5


<210>  12
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RDE element

<400>  12
uuauuuauu                                                                9


<210>  13
<211>  4
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RDE element

<400>  13
uuga                                                                     4


<210>  14
<211>  7
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RDE element

<400>  14
uggggau                                                                  7


<210>  15
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RDE element

<400>  15
cugcugcug                                                                9


<210>  16
<211>  5
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RDE element

<400>  16
auuga                                                                    5


<210>  17
<211>  18
<212>  PRT
<213>  Thoseaasigna virus 2A

<400>  17

Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210>  18
<211>  19
<212>  PRT
<213>  Porcine teschovirus-1

<400>  18

Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  19
<211>  20
<212>  PRT
<213>  Equine rhinitis A virus

<400>  19

Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp Val Glu Ser 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  20
<211>  22
<212>  PRT
<213>  foot and mouth disease virus

<400>  20

Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val 
1               5                   10                  15      


Glu Ser Asn Pro Gly Pro 
            20          


<210>  21
<211>  282
<212>  DNA
<213>  Homo sapiens

<400>  21
taattaagtg cttcccactt aaaacatatc aggccttcta tttatttaaa tatttaaatt       60

ttatatttat tgttgaatgt atggtttgct acctattgta actattattc ttaatcttaa      120

aactataaat atggatcttt tatgattctt tttgtaagcc ctaggggctc taaaatggtt      180

tcacttattt atcccaaaat atttattatt atgttgaatg ttaaatatag tatctatgta      240

gattggttag taaaactatt taataaattt gataaatata aa                         282


<210>  22
<211>  282
<212>  DNA
<213>  Homo sapiens

<400>  22
taattaagtg cttcccactt aaaacatatc aggccttcta tttatttaaa tatttaaatt       60

ttatatttat tgttgaatgt atggtttgct acctattgta actattattc ttaatcttaa      120

aactataaat atggatcttt tatgattgaa tttgtaagcc ctaggggctc taaaatggtt      180

tcacttattt atcccaaaat atttattatt atgttgaatg ttaaatatag tatctatgta      240

gattggttag taaaactatt taataaattt gataaatata aa                         282


<210>  23
<211>  585
<212>  DNA
<213>  Homo sapiens

<400>  23
tggttgtcct gcctgcaata tttgaatttt aaatctaaat ctatttatta atatttaaca       60

ttatttatat ggggaatata tttttagact catcaatcaa ataagtattt ataatagcaa      120

cttttgtgta atgaaaatga atatctatta atatatgtat tatttataat tcctatatcc      180

tgtgactgtc tcacttaatc ctttgttttc tgactaatta ggcaaggcta tgtgattaca      240

aggctttatc tcaggggcca actaggcagc caacctaagc aagatcccat gggttgtgtg      300

tttatttcac ttgatgatac aatgaacact tataagtgaa gtgatactat ccagttactg      360

ccggtttgaa aatatgcctg caatctgagc cagtgcttta atggcatgtc agacagaact      420

tgaatgtgtc aggtgaccct gatgaaaaca tagcatctca ggagatttca tgcctggtgc      480

ttccaaatat tgttgacaac tgtgactgta cccaaatgga aagtaactca tttgttaaaa      540

ttatcaatat ctaatatata tgaataaagt gtaagttcac aacta                      585


<210>  24
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MinP promoter

<400>  24
tagagggtat ataatggaag ctcgacttcc ag                                     32


<210>  25
<211>  131
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NFAT promoter

<400>  25
ggaggaaaaa ctgtttcata cagaaggcgt ggaggaaaaa ctgtttcata cagaaggcgt       60

ggaggaaaaa ctgtttcata cagaaggcgt agatctagac tctagagggt atataatgga      120

agctcgaatt c                                                           131


<210>  26
<211>  157
<212>  PRT
<213>  Homo sapiens

<400>  26

Tyr Phe Gly Lys Leu Glu Ser Lys Leu Ser Val Ile Arg Asn Leu Asn 
1               5                   10                  15      


Asp Gln Val Leu Phe Ile Asp Gln Gly Asn Arg Pro Leu Phe Glu Asp 
            20                  25                  30          


Met Thr Asp Ser Asp Cys Arg Asp Asn Ala Pro Arg Thr Ile Phe Ile 
        35                  40                  45              


Ile Ser Met Tyr Lys Asp Ser Gln Pro Arg Gly Met Ala Val Thr Ile 
    50                  55                  60                  


Ser Val Lys Cys Glu Lys Ile Ser Thr Leu Ser Cys Glu Asn Lys Ile 
65                  70                  75                  80  


Ile Ser Phe Lys Glu Met Asn Pro Pro Asp Asn Ile Lys Asp Thr Lys 
                85                  90                  95      


Ser Asp Ile Ile Phe Phe Gln Arg Ser Val Pro Gly His Asp Asn Lys 
            100                 105                 110         


Met Gln Phe Glu Ser Ser Ser Tyr Glu Gly Tyr Phe Leu Ala Cys Glu 
        115                 120                 125             


Lys Glu Arg Asp Leu Phe Lys Leu Ile Leu Lys Lys Glu Asp Glu Leu 
    130                 135                 140                 


Gly Asp Arg Ser Ile Met Phe Thr Val Gln Asn Glu Asp 
145                 150                 155         


<210>  27
<211>  193
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Ala Ala Glu Pro Val Glu Asp Asn Cys Ile Asn Phe Val Ala Met 
1               5                   10                  15      


Lys Phe Ile Asp Asn Thr Leu Tyr Phe Ile Ala Glu Asp Asp Glu Asn 
            20                  25                  30          


Leu Glu Ser Asp Tyr Phe Gly Lys Leu Glu Ser Lys Leu Ser Val Ile 
        35                  40                  45              


Arg Asn Leu Asn Asp Gln Val Leu Phe Ile Asp Gln Gly Asn Arg Pro 
    50                  55                  60                  


Leu Phe Glu Asp Met Thr Asp Ser Asp Cys Arg Asp Asn Ala Pro Arg 
65                  70                  75                  80  


Thr Ile Phe Ile Ile Ser Met Tyr Lys Asp Ser Gln Pro Arg Gly Met 
                85                  90                  95      


Ala Val Thr Ile Ser Val Lys Cys Glu Lys Ile Ser Thr Leu Ser Cys 
            100                 105                 110         


Glu Asn Lys Ile Ile Ser Phe Lys Glu Met Asn Pro Pro Asp Asn Ile 
        115                 120                 125             


Lys Asp Thr Lys Ser Asp Ile Ile Phe Phe Gln Arg Ser Val Pro Gly 
    130                 135                 140                 


His Asp Asn Lys Met Gln Phe Glu Ser Ser Ser Tyr Glu Gly Tyr Phe 
145                 150                 155                 160 


Leu Ala Cys Glu Lys Glu Arg Asp Leu Phe Lys Leu Ile Leu Lys Lys 
                165                 170                 175     


Glu Asp Glu Leu Gly Asp Arg Ser Ile Met Phe Thr Val Gln Asn Glu 
            180                 185                 190         


Asp 
    


<210>  28
<211>  157
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-18 mutant sequence

<400>  28

Tyr Phe Gly Lys Leu Glu Ser Lys Leu Ser Val Ile Arg Asn Leu Asn 
1               5                   10                  15      


Asp Gln Val Leu Phe Ile Asp Gln Gly Asn Arg Pro Leu Phe Glu Asp 
            20                  25                  30          


Met Thr Asp Ser Asp Cys Arg Asp Asn Ala Pro Arg Thr Ile Phe Ile 
        35                  40                  45              


Ile Ser Ala Tyr Gly Asp Ser Arg Ala Arg Gly Lys Ala Val Thr Ile 
    50                  55                  60                  


Ser Val Lys Cys Glu Lys Ile Ser Thr Leu Ser Cys Glu Asn Lys Ile 
65                  70                  75                  80  


Ile Ser Phe Lys Glu Met Asn Pro Pro Asp Asn Ile Lys Asp Thr Lys 
                85                  90                  95      


Ser Asp Ile Ile Phe Phe Gln Arg Ser Val Pro Gly His Asp Asn Lys 
            100                 105                 110         


Met Gln Phe Glu Ser Ser Ser Tyr Glu Gly Tyr Phe Leu Ala Cys Glu 
        115                 120                 125             


Lys Glu Arg Asp Leu Phe Lys Leu Ile Leu Lys Lys Glu Asp Glu Leu 
    130                 135                 140                 


Gly Asp Arg Ser Ile Met Phe Thr Val Gln Asn Glu Asp 
145                 150                 155         


<210>  29
<211>  193
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL18 mutant sequence

<400>  29

Met Ala Ala Glu Pro Val Glu Asp Asn Cys Ile Asn Phe Val Ala Met 
1               5                   10                  15      


Lys Phe Ile Asp Asn Thr Leu Tyr Phe Ile Ala Glu Asp Asp Glu Asn 
            20                  25                  30          


Leu Glu Ser Asp Tyr Phe Gly Lys Leu Glu Ser Lys Leu Ser Val Ile 
        35                  40                  45              


Arg Asn Leu Asn Asp Gln Val Leu Phe Ile Asp Gln Gly Asn Arg Pro 
    50                  55                  60                  


Leu Phe Glu Asp Met Thr Asp Ser Asp Cys Arg Asp Asn Ala Pro Arg 
65                  70                  75                  80  


Thr Ile Phe Ile Ile Ser Ala Tyr Gly Asp Ser Arg Ala Arg Gly Lys 
                85                  90                  95      


Ala Val Thr Ile Ser Val Lys Cys Glu Lys Ile Ser Thr Leu Ser Cys 
            100                 105                 110         


Glu Asn Lys Ile Ile Ser Phe Lys Glu Met Asn Pro Pro Asp Asn Ile 
        115                 120                 125             


Lys Asp Thr Lys Ser Asp Ile Ile Phe Phe Gln Arg Ser Val Pro Gly 
    130                 135                 140                 


His Asp Asn Lys Met Gln Phe Glu Ser Ser Ser Tyr Glu Gly Tyr Phe 
145                 150                 155                 160 


Leu Ala Cys Glu Lys Glu Arg Asp Leu Phe Lys Leu Ile Leu Lys Lys 
                165                 170                 175     


Glu Asp Glu Leu Gly Asp Arg Ser Ile Met Phe Thr Val Gln Asn Glu 
            180                 185                 190         


Asp 
    


<210>  30
<211>  582
<212>  DNA
<213>  Homo sapiens

<400>  30
atggctgctg aaccagtaga agacaattgc atcaactttg tggcaatgaa atttattgac       60

aatacgcttt actttatagc tgaagatgat gaaaacctgg aatcagatta ctttggcaag      120

cttgaatcta aattatcagt cataagaaat ttgaatgacc aagttctctt cattgaccaa      180

ggaaatcggc ctctatttga agatatgact gattctgact gtagagataa tgcaccccgg      240

accatattta ttataagtat gtataaagat agccagccta gaggtatggc tgtaactatc      300

tctgtgaagt gtgagaaaat ttcaactctc tcctgtgaga acaaaattat ttcctttaag      360

gaaatgaatc ctcctgataa catcaaggat acaaaaagtg acatcatatt ctttcagaga      420

agtgtcccag gacatgataa taagatgcaa tttgaatctt catcatacga aggatacttt      480

ctagcttgtg aaaaagagag agaccttttt aaactcattt tgaaaaaaga ggatgaattg      540

ggggatagat ctataatgtt cactgttcaa aacgaagact ag                         582


<210>  31
<211>  582
<212>  DNA
<213>  Homo sapiens

<400>  31
atggccgccg agcccgtgga ggacaactgc atcaacttcg tggccatgaa gttcatcgac       60

aacacgctgt acttcatcgc cgaggacgac gagaacctgg agtccgacta cttcggcaag      120

ctggagtcca agttgtccgt catcaggaac ttgaacgacc aggtgctctt catcgaccag      180

ggcaaccggc ccctgttcga ggacatgacc gactccgact gcagggacaa cgccccccgg      240

accatcttca tcatcagcat gtacaaggac agccagccca ggggcatggc cgtgaccatc      300

tccgtgaagt gcgagaagat ctccaccctc tcctgcgaga acaagatcat ctccttcaag      360

gagatgaacc cccccgacaa catcaaggac accaagagcg acatcatctt cttccagagg      420

agcgtccccg gccacgacaa caagatgcag ttcgagtcct cctcctacga gggctacttc      480

ctggcctgcg agaaggagag ggacctgttc aagctcatct tgaagaagga ggacgagttg      540

ggggacaggt ccatcatgtt caccgtgcag aacgaggact ag                         582


<210>  32
<211>  582
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL18 mutant sequence

<400>  32
atggctgctg aaccagtaga agacaattgc atcaactttg tggcaatgaa atttattgac       60

aatacgcttt actttatagc tgaagatgat gaaaacctgg aatcagatta ctttggcaag      120

cttgaatcta aattatcagt cataagaaat ttgaatgacc aagttctctt cattgaccaa      180

ggaaatcggc ctctatttga agatatgact gattctgact gtagagataa tgcaccccgg      240

accatattta tcatcagcgc ctacggcgac agcagggcca ggggcaaggc tgtaactatc      300

tctgtgaagt gtgagaaaat ttcaactctc tcctgtgaga acaaaattat ttcctttaag      360

gaaatgaatc ctcctgataa catcaaggat acaaaaagtg acatcatatt ctttcagaga      420

agtgtcccag gacatgataa taagatgcaa tttgaatctt catcatacga aggatacttt      480

ctagcttgtg aaaaagagag agaccttttt aaactcattt tgaaaaaaga ggatgaattg      540

ggggatagat ctataatgtt cactgttcaa aacgaagact ag                         582


<210>  33
<211>  582
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL18 mutant sequence

<400>  33
atggccgccg agcccgtgga ggacaactgc atcaacttcg tggccatgaa gttcatcgac       60

aacacgctgt acttcatcgc cgaggacgac gagaacctgg agtccgacta cttcggcaag      120

ctggagtcca agttgtccgt catcaggaac ttgaacgacc aggtgctctt catcgaccag      180

ggcaaccggc ccctgttcga ggacatgacc gactccgact gcagggacaa cgccccccgg      240

accatcttca tcatcagcgc ctacggcgac agcagggcca ggggcaaggc cgtgaccatc      300

tccgtgaagt gcgagaagat ctccaccctc tcctgcgaga acaagatcat ctccttcaag      360

gagatgaacc cccccgacaa catcaaggac accaagagcg acatcatctt cttccagagg      420

agcgtccccg gccacgacaa caagatgcag ttcgagtcct cctcctacga gggctacttc      480

ctggcctgcg agaaggagag ggacctgttc aagctcatct tgaagaagga ggacgagttg      540

ggggacaggt ccatcatgtt caccgtgcag aacgaggact ag                         582


