                         SEQUENCE LISTING

<110>  THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE 
       SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
 
<120>  CROSS SPECIES SINGLE DOMAIN ANTIBODIES TARGETING PD-L1 FOR 
       TREATING SOLID TUMORS

<130>  4239-106355-02

<150>  US 63/208,755
<151>  2021-06-09

<160>  31    

<170>  PatentIn version 3.5

<210>  1
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  1

Ala Arg Val Asp Gln Thr Pro Arg Ser Val Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Leu Arg Asp Ser Ser Tyr Ala Leu Gly 
            20                  25                  30          


Ser Thr Tyr Trp Tyr Arg Lys Lys Ser Gly Ser Thr Asn Glu Glu Ser 
        35                  40                  45              


Ile Ser Lys Gly Gly Arg Tyr Val Glu Thr Val Asn Ser Gly Ser Lys 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Asn Asp Leu Thr Val Glu Asp Ser Gly Thr 
65                  70                  75                  80  


Tyr Arg Cys Lys Tyr Thr Ser Arg Leu Arg Arg Glu Gly Pro Leu Ser 
                85                  90                  95      


Trp Asp Gly Asn Thr Val Tyr Gly Gly Gly Thr Val Val Thr Val Asn 
            100                 105                 110         


<210>  2
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  2

Ala Arg Val Asp Gln Thr Pro Arg Ser Val Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Leu Arg Asp Thr Asn Tyr Ala Leu Gly 
            20                  25                  30          


Ser Thr Tyr Trp Tyr Arg Lys Lys Leu Gly Ser Thr Asn Glu Glu Ser 
        35                  40                  45              


Ile Ser Lys Gly Gly Arg Tyr Val Glu Thr Val Asn Ser Gly Ser Lys 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Asn Asp Leu Thr Val Glu Asp Ser Gly Thr 
65                  70                  75                  80  


Tyr Arg Cys Lys Asn Leu Gly His Pro Met Tyr Ile Ala Gly Ala Ile 
                85                  90                  95      


Cys Arg Pro Leu Pro Ile Tyr Gly Gly Gly Thr Val Val Thr Val Asn 
            100                 105                 110         


<210>  3
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  3

Ala Arg Val Asp Gln Thr Pro Arg Ser Val Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Leu Arg Asp Thr Ser Tyr Ala Leu Gly 
            20                  25                  30          


Ser Thr Tyr Trp Tyr Arg Lys Lys Ser Gly Ser Thr Asn Glu Glu Ser 
        35                  40                  45              


Ile Ser Lys Gly Gly Arg Tyr Val Glu Thr Val Asn Ser Gly Ser Lys 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Asn Asp Leu Thr Val Glu Asp Ser Gly Thr 
65                  70                  75                  80  


Tyr Arg Cys Lys Phe Lys Ser Asn Thr Glu Phe Leu Asn Pro Leu Thr 
                85                  90                  95      


Val Ser Met Ser Thr Ile Tyr Gly Gly Gly Thr Val Val Thr Val Asn 
            100                 105                 110         


<210>  4
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  4

Ala Arg Val Asp Gln Thr Pro Gln Thr Ile Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Leu Arg Asp Ser Asn Tyr Ala Leu Gly 
            20                  25                  30          


Ser Thr Tyr Trp Tyr Arg Lys Lys Ser Gly Ser Thr Asn Glu Glu Ser 
        35                  40                  45              


Ile Ser Lys Gly Gly Arg Tyr Val Glu Thr Val Asn Ser Gly Ser Lys 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Asn Asp Leu Thr Val Glu Asp Ser Gly Thr 
65                  70                  75                  80  


Tyr Arg Cys Lys Thr Gln Lys Ala Ile Pro Cys Asn Met Asn Gly Tyr 
                85                  90                  95      


Val Cys Gly Val Thr Ile Tyr Gly Gly Gly Thr Val Val Thr Val Asn 
            100                 105                 110         


<210>  5
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  5

Ala Arg Val Asp Gln Thr Pro Gln Thr Ile Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Leu Arg Asp Thr Asn Tyr Ala Leu Gly 
            20                  25                  30          


Ser Thr Tyr Trp Tyr Arg Lys Lys Leu Gly Ser Thr Asn Glu Glu Ser 
        35                  40                  45              


Ile Ser Lys Gly Gly Arg Tyr Val Glu Thr Val Asn Ser Gly Ser Lys 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Asn Asp Leu Thr Val Glu Asp Ser Gly Thr 
65                  70                  75                  80  


Tyr Arg Cys Lys Asn Thr Ser Pro Trp Leu Thr Tyr Ser Pro Trp Thr 
                85                  90                  95      


Val Ser Gly Gln Thr Ser Tyr Gly Gly Gly Thr Val Val Thr Val Asn 
            100                 105                 110         


<210>  6
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  6

Ala Arg Val Asp Gln Thr Pro Arg Ser Val Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Leu Arg Asp Thr Ser Tyr Ala Leu Gly 
            20                  25                  30          


Ser Thr Tyr Trp Tyr Arg Lys Lys Leu Gly Ser Thr Asn Glu Glu Ser 
        35                  40                  45              


Ile Ser Lys Gly Gly Arg Tyr Val Glu Thr Val Asn Ser Gly Ser Lys 
    50                  55                  60                  


Thr Phe Ser Leu Arg Ile Asn Asp Leu Thr Val Glu Asp Ser Gly Thr 
65                  70                  75                  80  


Tyr Arg Cys Lys Val Gln Thr Thr Trp Ser Tyr Leu Ser Pro Tyr Lys 
                85                  90                  95      


Ile Glu Phe Ala Thr Val Tyr Gly Gly Gly Thr Val Val Thr Val Asn 
            100                 105                 110         


<210>  7
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  7

Ala Arg Val Asp Gln Thr Pro Arg Ser Val Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Leu Arg Asp Thr Asn Tyr Ala Leu Gly 
            20                  25                  30          


Ser Thr Tyr Trp Tyr Arg Lys Lys Leu Gly Ser Thr Asn Glu Glu Ser 
        35                  40                  45              


Ile Ser Lys Gly Gly Arg Tyr Val Glu Thr Val Asn Ser Gly Ser Lys 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Asn Asp Leu Thr Val Glu Asp Ser Gly Thr 
65                  70                  75                  80  


Tyr Arg Cys Lys Ser Thr Thr Pro Trp Asn Asn Leu Thr Ser Phe Thr 
                85                  90                  95      


Ser Glu Arg Val Thr Ile Tyr Gly Gly Gly Thr Val Val Thr Val Asn 
            100                 105                 110         


<210>  8
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  8

Ala Arg Val Asp Gln Thr Pro Arg Ser Val Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Leu Arg Asp Thr Ser Tyr Ala Leu Gly 
            20                  25                  30          


Ser Thr Tyr Trp Tyr Arg Lys Lys Leu Gly Ser Thr Asn Glu Glu Ser 
        35                  40                  45              


Ile Ser Lys Gly Gly Arg Tyr Val Glu Thr Val Asn Ser Gly Ser Lys 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Asn Asp Leu Thr Val Glu Asp Ser Gly Thr 
65                  70                  75                  80  


Tyr Arg Cys Lys Met Asn Gln Arg Tyr Pro Cys Asp Asn Asn Ser Trp 
                85                  90                  95      


Trp Ser Leu Tyr Cys Gly Thr Thr Val Tyr Gly Gly Gly Thr Val Val 
            100                 105                 110         


Thr Val Asn 
        115 


<210>  9
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  9

Ala Arg Val Asp Gln Thr Pro Gln Thr Ile Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Leu Arg Asp Thr Ser Tyr Ala Leu Gly 
            20                  25                  30          


Ser Thr Tyr Trp Tyr Arg Lys Lys Ser Gly Ser Thr Asn Glu Glu Ser 
        35                  40                  45              


Ile Ser Lys Gly Gly Arg Tyr Val Glu Thr Val Asn Ser Gly Ser Lys 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Asn Asp Leu Arg Val Glu Asp Ser Gly Thr 
65                  70                  75                  80  


Tyr Arg Cys Lys Tyr Ser Ser Ser Trp Gln Lys Ala Thr Glu Gly Val 
                85                  90                  95      


Trp Glu Ala Met Thr Glu Tyr Gly Gly Gly Thr Val Val Thr Val Asn 
            100                 105                 110         


<210>  10
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  10

Ala Arg Val Asp Gln Thr Pro Arg Ser Val Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Leu Arg Asp Thr Asn Tyr Ala Leu Gly 
            20                  25                  30          


Ser Thr Tyr Trp Tyr Arg Lys Lys Ser Gly Ser Thr Asn Glu Glu Ser 
        35                  40                  45              


Ile Ser Lys Gly Gly Arg Tyr Val Glu Thr Val Asn Ser Gly Ser Lys 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Asn Asp Leu Thr Val Glu Asp Ser Gly Thr 
65                  70                  75                  80  


Tyr Arg Cys Lys Gln Ser Ala Ser Leu Trp Ile Pro Asn Leu Leu Arg 
                85                  90                  95      


Trp Val Pro Val Ile Ser Tyr Gly Gly Gly Thr Val Val Thr Val Asn 
            100                 105                 110         


<210>  11
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  11

Ala Arg Val Asp Gln Thr Pro Arg Ser Val Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Leu Arg Asp Thr Asn Tyr Ala Leu Gly 
            20                  25                  30          


Ser Thr Tyr Trp Tyr Arg Lys Lys Ser Gly Ser Thr Asn Glu Glu Ser 
        35                  40                  45              


Ile Ser Lys Gly Gly Arg Tyr Val Glu Thr Val Asn Ser Gly Ser Lys 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Asn Asp Leu Thr Val Glu Asp Ser Gly Thr 
65                  70                  75                  80  


Tyr Arg Cys Lys Thr Ser Ser Lys Pro Leu Leu Val Ser His Asn Val 
                85                  90                  95      


Trp Ser Ala Trp Thr Glu Tyr Gly Gly Gly Thr Val Val Thr Val Asn 
            100                 105                 110         


<210>  12
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  12

Ala Arg Val Asp Gln Thr Pro Arg Ser Val Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Leu Arg Asp Thr Asn Tyr Ala Leu Gly 
            20                  25                  30          


Ser Thr Tyr Trp Tyr Arg Lys Lys Ser Gly Ser Thr Asn Glu Glu Ser 
        35                  40                  45              


Ile Ser Lys Gly Gly Arg Tyr Val Glu Thr Val Asn Ser Gly Ser Lys 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Asn Asp Leu Thr Val Glu Asp Ser Gly Thr 
65                  70                  75                  80  


Tyr Arg Cys Lys His Gln Ser Ser Trp Arg Arg Gln Ala Pro Arg Val 
                85                  90                  95      


Met Glu Met Gln Thr Leu Tyr Gly Gly Gly Thr Val Val Thr Val Asn 
            100                 105                 110         


<210>  13
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  13

Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr Ser Thr 
1               5                   10                  15      


Leu Arg 
        


<210>  14
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Ser or Thr

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa = Asn or Ser

<400>  14

Asp Xaa Xaa Tyr Ala Leu Gly Ser Thr 
1               5                   


<210>  15
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  15

Asn Glu Glu Ser Ile Ser Lys Gly 
1               5               


<210>  16
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  16

Asn Ser Gly Ser Lys 
1               5   


<210>  17
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  17
gctcgagtgg accaaacacc gagatcagta acaaaggaga cgggcgaatc actgaccatc       60

aactgtgtcc tacgagatag tagctatgca ttgggcagca cgtactggta tcgaaaaaaa      120

tcgggctcaa caaacgagga gagcatatcg aaaggtggac gatatgttga aacagttaac      180

agcggatcaa agtccttttc tttgagaatt aatgatctaa cagttgaaga cagtggcacg      240

tatcgatgca agtacacgtc gcgcctccgg cgggaggggc ccttgtcgtg ggacgggaac      300

acggtgtacg gaggtggcac tgtcgtgact gtgaat                                336


<210>  18
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  18
gctcgagtgg accaaacacc gagatcagta acaaaggaga cgggcgaatc actgaccatc       60

aactgtgtcc tacgagatac taactatgca ttgggcagca cgtactggta tcgaaaaaaa      120

ttgggctcaa caaacgagga gagcatatcg aaaggtggac gatatgttga aacagttaac      180

agcggatcaa agtccttttc tttgagaatt aatgatctaa cagttgaaga cagtggcacg      240

tatcgatgca agaacctcgg gcacccgatg tacatcgcgg gcgccatctg ccggcccttg      300

ccgatctacg gaggtggcac tgtcgtgact gtgaat                                336


<210>  19
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  19
gctcgagtgg accaaacacc gagatcagta acaaaggaga cgggcgaatc actgaccatc       60

aactgtgtcc tacgagatac tagctatgca ttgggcagca cgtactggta tcgaaaaaaa      120

tcgggctcaa caaacgagga gagcatatcg aaaggtggac gatatgttga aacagttaac      180

agcggatcaa agtccttttc tttgagaatt aatgatctaa cagttgaaga cagtggcacg      240

tatcgatgca agttcaagag caacaccgag ttcctcaacc ccttgacggt ctcgatgagc      300

acgatctacg gaggtggcac tgtcgtgact gtgaat                                336


<210>  20
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  20
gctcgagtgg accaaacacc gcaaacaata acaaaggaga cgggcgaatc actgaccatc       60

aactgtgtcc tacgagatag taactatgca ttgggcagca cgtactggta tcgaaaaaaa      120

tcgggctcaa caaacgagga gagcatatcg aaaggtggac gatatgttga aacagttaac      180

agcggatcaa agtccttttc tttgagaatt aatgatctaa cagttgaaga cagtggcacg      240

tatcgatgca agacgcagaa ggccatcccc tgcaacatga acgggtacgt gtgcggggtg      300

acgatctacg gaggtggcac tgtcgtgact gtgaat                                336


<210>  21
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  21
gctcgagtgg accaaacacc gcaaacaata acaaaggaga cgggcgaatc actgaccatc       60

aactgtgtcc tacgagatac taactatgca ttgggcagca cgtactggta tcgaaaaaaa      120

ttgggctcaa caaacgagga gagcatatcg aaaggtggac gatatgttga aacagttaac      180

agcggatcaa agtccttttc tttgagaatt aatgatctaa cagttgaaga cagtggcacg      240

tatcgatgca agaacacgtc cccgtggctg acgtacagcc cctggaccgt cagcgggcag      300

acgtcgtacg gaggtggcac tgtcgtgact gtgaat                                336


<210>  22
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  22
gctcgagtgg accaaacacc gagatcagta acaaaggaga cgggcgaatc actgaccatc       60

aactgtgtcc tacgagatac tagctatgca ttgggcagca cgtactggta tcgaaaaaaa      120

ttgggctcaa caaacgagga gagcatatcg aaaggtggac gatatgttga aacagttaac      180

agcggctcaa agaccttttc tttgagaatt aatgatctaa cagttgaaga cagtggcacg      240

tatcgatgca aggtgcagac cacctggtcc tacttgagcc cgtacaagat cgagttcgcg      300

accgtctacg gaggtggcac tgtcgtgact gtgaat                                336


<210>  23
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  23
gctcgagtgg accaaacacc gagatcagta acaaaggaga cgggcgaatc actgaccatc       60

aactgtgtcc tacgagatac taactatgca ttgggcagca cgtactggta tcgaaaaaaa      120

ttgggctcaa caaacgagga gagcatatcg aaaggtggac gatatgttga aacagttaac      180

agcggatcaa agtccttttc tttgagaatt aatgatctaa cagttgaaga cagtggcacg      240

tatcgatgca agtcgaccac gccctggaac aacctcacgt cgttcacgtc cgagcgggtg      300

accatctacg gaggtggcac tgtcgtgact gtgaat                                336


<210>  24
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  24
gctcgagtgg accaaacacc gagatcagta acaaaggaga cgggcgaatc actgaccatc       60

aactgtgtcc tacgagatac tagctatgca ttgggcagca cgtactggta tcgaaaaaaa      120

ttgggctcaa caaacgagga gagcatatcg aaaggtggac gatatgttga aacagttaac      180

agcggatcaa agtccttttc tttgagaatt aatgatctaa cagttgaaga cagtggcacg      240

tatcgatgca agatgaacca gcgctacccc tgcgacaaca actcctggtg gtccctgtac      300

tgcgggacca cggtctacgg aggtggcact gtcgtgactg tgaat                      345


<210>  25
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  25
gctcgagtgg accaaacacc gcaaacaata acaaaggaga cgggcgaatc actgaccatc       60

aactgtgtcc tacgagatac tagctatgca ttgggcagca cgtactggta tcgaaaaaaa      120

tcgggctcaa caaacgagga gagcatatcg aaaggtggac gatatgttga aacagttaac      180

agcggatcaa agtccttttc tttgagaatt aatgatctac gagttgaaga cagtggcacg      240

tatcgatgca agtactcgag ctcctggcag aaggccaccg agggcgtctg ggaggcgatg      300

acggagtacg gaggtggcac tgtcgtgact gtgaat                                336


<210>  26
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  26
gctcgagtgg accaaacacc gagatcagta acaaaggaga cgggcgaatc actgaccatc       60

aactgtgtcc tacgagatac taactatgca ttgggcagca cgtactggta tcgaaaaaaa      120

tcgggctcaa caaacgagga gagcatatcg aaaggtggac gatatgttga aacagttaac      180

agcggatcaa agtccttttc tttgagaatt aatgatctaa cagttgaaga cagtggcacg      240

tatcgatgca agcagtcggc ctcgctctgg atcccgaacc tcctccgctg ggtgcccgtg      300

atctcgtacg gaggtggcac tgtcgtgact gtgaat                                336


<210>  27
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  27
gctcgagtgg accaaacacc gagatcagta acaaaggaga cgggcgaatc actgaccatc       60

aactgtgttc tacgagatac taactatgca ttgggcagca cgtactggta tcgaaaaaaa      120

tcgggctcaa caaacgagga gagcatatcg aaaggtggac gatatgttga aacagttaac      180

agcggatcaa agtccttttc tttgagaatt aatgatctaa cagttgaaga cagtggcacg      240

tatcgatgca agacgtcgtc gaagcccctc ctcgtctccc acaacgtgtg gtcggcctgg      300

acggagtacg gaggtggcac tgtcgtgact gtgaat                                336


<210>  28
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  28
gctcgagtgg accaaacacc gagatcagta acaaaggaga cgggcgaatc actgaccatc       60

aactgtgtcc tacgagatac taactatgca ttgggcagca cgtactggta tcgaaaaaaa      120

tcgggctcaa caaacgagga gagcatatcg aaaggtggac gatatgttga aacagttaac      180

agcggatcaa agtccttttc tttgagaatt aatgatctaa cagttgaaga cagtggcacg      240

tatcgatgca agcaccagtc gtcctggagg cgccaggccc cgcgcgtgat ggagatgcag      300

acgttgtacg gaggtggcac tgtcgtgact gtgaat                                336


<210>  29
<211>  238
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu 
1               5                   10                  15      


Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu 
        35                  40                  45              


Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile 
    50                  55                  60                  


Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser 
65                  70                  75                  80  


Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val 
    130                 135                 140                 


Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr 
145                 150                 155                 160 


Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser 
                165                 170                 175     


Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn 
            180                 185                 190         


Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr 
        195                 200                 205             


Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu 
    210                 215                 220                 


Val Ile Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
225                 230                 235             


<210>  30
<211>  237
<212>  PRT
<213>  Mus musculus

<400>  30

Met Arg Ile Phe Ala Gly Ile Ile Phe Thr Ala Cys Cys His Leu Leu 
1               5                   10                  15      


Arg Ala Phe Thr Ile Thr Ala Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Val Thr Met Glu Cys Arg Phe Pro Val Glu Arg Glu Leu 
        35                  40                  45              


Asp Leu Leu Ala Leu Val Val Tyr Trp Glu Lys Glu Asp Glu Gln Val 
    50                  55                  60                  


Ile Gln Phe Val Ala Gly Glu Glu Asp Leu Lys Pro Gln His Ser Asn 
65                  70                  75                  80  


Phe Arg Gly Arg Ala Ser Leu Pro Lys Asp Gln Leu Leu Lys Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Cys Cys Ile Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Leu 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Arg Lys Ile Asn Gln Arg Ile Ser Val Asp 
    130                 135                 140                 


Pro Ala Thr Ser Glu His Glu Leu Ile Cys Gln Ala Glu Gly Tyr Pro 
145                 150                 155                 160 


Glu Ala Glu Val Ile Trp Thr Asn Ser Asp His Gln Pro Val Ser Gly 
                165                 170                 175     


Lys Arg Ser Val Thr Thr Ser Arg Thr Glu Gly Met Leu Leu Asn Val 
            180                 185                 190         


Thr Ser Ser Leu Arg Val Asn Ala Thr Ala Asn Asp Val Phe Tyr Cys 
        195                 200                 205             


Thr Phe Trp Arg Ser Gln Pro Gly Gln Asn His Thr Ala Glu Leu Ile 
    210                 215                 220                 


Ile Pro Glu Leu Pro Ala Thr His Pro Pro Gln Asn Arg 
225                 230                 235         


<210>  31
<211>  236
<212>  PRT
<213>  Canis familiaris

<400>  31

Met Arg Met Phe Ser Val Phe Thr Phe Met Ala Tyr Cys His Leu Leu 
1               5                   10                  15      


Lys Ala Phe Thr Ile Thr Val Ser Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Gly Asn Val Thr Met Glu Cys Lys Phe Pro Val Glu Lys Gln Leu 
        35                  40                  45              


Asn Leu Phe Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Lys Ile 
    50                  55                  60                  


Ile Gln Phe Val Asn Gly Lys Glu Asp Leu Lys Val Gln His Ser Ser 
65                  70                  75                  80  


Tyr Ser Gln Arg Ala Gln Leu Leu Lys Asp Gln Leu Phe Leu Gly Lys 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Arg Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Cys Cys Leu Ile Gly Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Leu 
        115                 120                 125             


Lys Val His Ala Pro Tyr Arg Asn Ile Ser Gln Arg Ile Ser Val Asp 
    130                 135                 140                 


Pro Val Thr Ser Glu His Glu Leu Met Cys Gln Ala Glu Gly Tyr Pro 
145                 150                 155                 160 


Glu Ala Glu Val Ile Trp Thr Ser Ser Asp His Arg Val Leu Ser Gly 
                165                 170                 175     


Lys Thr Thr Ile Thr Asn Ser Asn Arg Glu Glu Lys Leu Phe Asn Val 
            180                 185                 190         


Thr Ser Thr Leu Asn Ile Asn Ala Thr Ala Asn Glu Ile Phe Tyr Cys 
        195                 200                 205             


Thr Phe Gln Arg Ser Gly Pro Glu Glu Asn Asn Thr Ala Glu Leu Val 
    210                 215                 220                 


Ile Pro Glu Arg Leu Pro Val Pro Ala Ser Glu Arg 
225                 230                 235     


