                         SEQUENCE LISTING

<110>  Ness Therapeutics, Inc.
 
<120>  COMPOUNDS HAVING 
       5-(2-FLUORO-6-HYDROXYPHENYL)-1,2,5-THIADIAZOLIDIN-3-ONE 
       1,1-DIOXIDE AS INHIBITORS OF PROTEIN KINASE PHOSPHATASE ENZYMES

<130>  87591.00116
<150>  63/209,274
<151>  2021-06-10	

<160>  1     

<170>  PatentIn version 3.5

<210>  1
<211>  641
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant PTPN2 with an N terminal GST-Tag  (Cat# 31592, 
       ActiveMotif)

<400>  1

Met Ser Pro Ile Leu Gly Tyr Trp Lys Ile Lys Gly Leu Val Gln Pro 
1               5                   10                  15      


Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu Lys Tyr Glu Glu His Leu 
            20                  25                  30          


Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg Asn Lys Lys Phe Glu Leu 
        35                  40                  45              


Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Val Lys 
    50                  55                  60                  


Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile Ala Asp Lys His Asn 
65                  70                  75                  80  


Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu Glu 
                85                  90                  95      


Gly Ala Val Leu Asp Ile Arg Tyr Gly Val Ser Arg Ile Ala Tyr Ser 
            100                 105                 110         


Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu Ser Lys Leu Pro Glu 
        115                 120                 125             


Met Leu Lys Met Phe Glu Asp Arg Leu Cys His Lys Thr Tyr Leu Asn 
    130                 135                 140                 


Gly Asp His Val Thr His Pro Asp Phe Met Leu Tyr Asp Ala Leu Asp 
145                 150                 155                 160 


Val Val Leu Tyr Met Asp Pro Met Cys Leu Asp Ala Phe Pro Lys Leu 
                165                 170                 175     


Val Cys Phe Lys Lys Arg Ile Glu Ala Ile Pro Gln Ile Asp Lys Tyr 
            180                 185                 190         


Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro Leu Gln Gly Trp Gln Ala 
        195                 200                 205             


Thr Phe Gly Gly Gly Asp His Pro Pro Lys Ser Asp Leu Val Pro Arg 
    210                 215                 220                 


Gly Ser Met Pro Thr Thr Ile Glu Arg Glu Phe Glu Glu Leu Asp Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Gln Pro Leu Tyr Leu Glu Ile Arg Asn Glu Ser His 
                245                 250                 255     


Asp Tyr Pro His Arg Val Ala Lys Phe Pro Glu Asn Arg Asn Arg Asn 
            260                 265                 270         


Arg Tyr Arg Asp Val Ser Pro Tyr Asp His Ser Arg Val Lys Leu Gln 
        275                 280                 285             


Asn Ala Glu Asn Asp Tyr Ile Asn Ala Ser Leu Val Asp Ile Glu Glu 
    290                 295                 300                 


Ala Gln Arg Ser Tyr Ile Leu Thr Gln Gly Pro Leu Pro Asn Thr Cys 
305                 310                 315                 320 


Cys His Phe Trp Leu Met Val Trp Gln Gln Lys Thr Lys Ala Val Val 
                325                 330                 335     


Met Leu Asn Arg Ile Val Glu Lys Glu Ser Val Lys Cys Ala Gln Tyr 
            340                 345                 350         


Trp Pro Thr Asp Asp Gln Glu Met Leu Phe Lys Glu Thr Gly Phe Ser 
        355                 360                 365             


Val Lys Leu Leu Ser Glu Asp Val Lys Ser Tyr Tyr Thr Val His Leu 
    370                 375                 380                 


Leu Gln Leu Glu Asn Ile Asn Ser Gly Glu Thr Arg Thr Ile Ser His 
385                 390                 395                 400 


Phe His Tyr Thr Thr Trp Pro Asp Phe Gly Val Pro Glu Ser Pro Ala 
                405                 410                 415     


Ser Phe Leu Asn Phe Leu Phe Lys Val Arg Glu Ser Gly Ser Leu Asn 
            420                 425                 430         


Pro Asp His Gly Pro Ala Val Ile His Cys Ser Ala Gly Ile Gly Arg 
        435                 440                 445             


Ser Gly Thr Phe Ser Leu Val Asp Thr Cys Leu Val Leu Met Glu Lys 
    450                 455                 460                 


Gly Asp Asp Ile Asn Ile Lys Gln Val Leu Leu Asn Met Arg Lys Tyr 
465                 470                 475                 480 


Arg Met Gly Leu Ile Gln Thr Pro Asp Gln Leu Arg Phe Ser Tyr Met 
                485                 490                 495     


Ala Ile Ile Glu Gly Ala Lys Cys Ile Lys Gly Asp Ser Ser Ile Gln 
            500                 505                 510         


Lys Arg Trp Lys Glu Leu Ser Lys Glu Asp Leu Ser Pro Ala Phe Asp 
        515                 520                 525             


His Ser Pro Asn Lys Ile Met Thr Glu Lys Tyr Asn Gly Asn Arg Ile 
    530                 535                 540                 


Gly Leu Glu Glu Glu Lys Leu Thr Gly Asp Arg Cys Thr Gly Leu Ser 
545                 550                 555                 560 


Ser Lys Met Gln Asp Thr Met Glu Glu Asn Ser Glu Ser Ala Leu Arg 
                565                 570                 575     


Lys Arg Ile Arg Glu Asp Arg Lys Ala Thr Thr Ala Gln Lys Val Gln 
            580                 585                 590         


Gln Met Lys Gln Arg Leu Asn Glu Asn Glu Arg Lys Arg Lys Arg Trp 
        595                 600                 605             


Leu Tyr Trp Gln Pro Ile Leu Thr Lys Met Gly Phe Met Ser Val Ile 
    610                 615                 620                 


Leu Val Gly Ala Phe Val Gly Trp Thr Leu Phe Phe Gln Gln Asn Ala 
625                 630                 635                 640 


Leu 
    


