                         SEQUENCE LISTING

<110>  Scribe Therapeutics Inc.
 
<120>  COMPOSITIONS OF GLYCOPROTEIN PARTICLES

<130>  SCRB-037/01WO 333322-2187

<150>  62/208,930
<151>  2021-06-09

<160>  1177  

<170>  PatentIn version 3.5

<210>  1
<211>  511
<212>  PRT
<213>  Vesicular Stomatitis Virus

<400>  1

Met Lys Cys Leu Leu Tyr Leu Ala Phe Leu Phe Ile Gly Val Asn Cys 
1               5                   10                  15      


Lys Phe Thr Ile Val Phe Pro His Asn Gln Lys Gly Asn Trp Lys Asn 
            20                  25                  30          


Val Pro Ser Asn Tyr His Tyr Cys Pro Ser Ser Ser Asp Leu Asn Trp 
        35                  40                  45              


His Asn Asp Leu Ile Gly Thr Ala Leu Gln Val Lys Met Pro Lys Ser 
    50                  55                  60                  


His Lys Ala Ile Gln Ala Asp Gly Trp Met Cys His Ala Ser Lys Trp 
65                  70                  75                  80  


Val Thr Thr Cys Asp Phe Arg Trp Tyr Gly Pro Lys Tyr Ile Thr His 
                85                  90                  95      


Ser Ile Arg Ser Phe Thr Pro Ser Val Glu Gln Cys Lys Glu Ser Ile 
            100                 105                 110         


Glu Gln Thr Lys Gln Gly Thr Trp Leu Asn Pro Gly Phe Pro Pro Gln 
        115                 120                 125             


Ser Cys Gly Tyr Ala Thr Val Thr Asp Ala Glu Ala Val Ile Val Gln 
    130                 135                 140                 


Val Thr Pro His His Val Leu Val Asp Glu Tyr Thr Gly Glu Trp Val 
145                 150                 155                 160 


Asp Ser Gln Phe Ile Asn Gly Lys Cys Ser Asn Tyr Ile Cys Pro Thr 
                165                 170                 175     


Val His Asn Ser Thr Thr Trp His Ser Asp Tyr Lys Val Lys Gly Leu 
            180                 185                 190         


Cys Asp Ser Asn Leu Ile Ser Met Asp Ile Thr Phe Phe Ser Glu Asp 
        195                 200                 205             


Gly Glu Leu Ser Ser Leu Gly Lys Glu Gly Thr Gly Phe Arg Ser Asn 
    210                 215                 220                 


Tyr Phe Ala Tyr Glu Thr Gly Gly Lys Ala Cys Lys Met Gln Tyr Cys 
225                 230                 235                 240 


Lys His Trp Gly Val Arg Leu Pro Ser Gly Val Trp Phe Glu Met Ala 
                245                 250                 255     


Asp Lys Asp Leu Phe Ala Ala Ala Arg Phe Pro Glu Cys Pro Glu Gly 
            260                 265                 270         


Ser Ser Ile Ser Ala Pro Ser Gln Thr Ser Val Asp Val Ser Leu Ile 
        275                 280                 285             


Gln Asp Val Glu Arg Ile Leu Asp Tyr Ser Leu Cys Gln Glu Thr Trp 
    290                 295                 300                 


Ser Lys Ile Arg Ala Gly Leu Pro Ile Ser Pro Val Asp Leu Ser Tyr 
305                 310                 315                 320 


Leu Ala Pro Lys Asn Pro Gly Thr Gly Pro Ala Phe Thr Ile Ile Asn 
                325                 330                 335     


Gly Thr Leu Lys Tyr Phe Glu Thr Arg Tyr Ile Arg Val Asp Ile Ala 
            340                 345                 350         


Ala Pro Ile Leu Ser Arg Met Val Gly Met Ile Ser Gly Thr Thr Thr 
        355                 360                 365             


Glu Arg Glu Leu Trp Asp Asp Trp Ala Pro Tyr Glu Asp Val Glu Ile 
    370                 375                 380                 


Gly Pro Asn Gly Val Leu Arg Thr Ser Ser Gly Tyr Lys Phe Pro Leu 
385                 390                 395                 400 


Tyr Met Ile Gly His Gly Met Leu Asp Ser Asp Leu His Leu Ser Ser 
                405                 410                 415     


Lys Ala Gln Val Phe Glu His Pro His Ile Gln Asp Ala Ala Ser Gln 
            420                 425                 430         


Leu Pro Asp Asp Glu Ser Leu Phe Phe Gly Asp Thr Gly Leu Ser Lys 
        435                 440                 445             


Asn Pro Ile Glu Leu Val Glu Gly Trp Phe Ser Ser Trp Lys Ser Ser 
    450                 455                 460                 


Ile Ala Ser Phe Phe Phe Ile Ile Gly Leu Ile Ile Gly Leu Phe Leu 
465                 470                 475                 480 


Val Leu Arg Val Gly Ile His Leu Cys Ile Lys Leu Lys His Thr Lys 
                485                 490                 495     


Lys Arg Gln Ile Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Lys 
            500                 505                 510     


<210>  2
<211>  856
<212>  PRT
<213>  Human Immunodeficiency Virus

<400>  2

Met Arg Val Lys Glu Lys Tyr Gln His Leu Trp Arg Trp Gly Trp Arg 
1               5                   10                  15      


Trp Gly Thr Met Leu Leu Gly Met Leu Met Ile Cys Ser Ala Thr Glu 
            20                  25                  30          


Lys Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala 
        35                  40                  45              


Thr Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Thr Glu 
    50                  55                  60                  


Val His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn 
65                  70                  75                  80  


Pro Gln Glu Val Val Leu Val Asn Val Thr Glu Asn Phe Asn Met Trp 
                85                  90                  95      


Lys Asn Asp Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu Trp 
            100                 105                 110         


Asp Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Ser 
        115                 120                 125             


Leu Lys Cys Thr Asp Leu Lys Asn Asp Thr Asn Thr Asn Ser Ser Ser 
    130                 135                 140                 


Gly Arg Met Ile Met Glu Lys Gly Glu Ile Lys Asn Cys Ser Phe Asn 
145                 150                 155                 160 


Ile Ser Thr Ser Ile Arg Gly Lys Val Gln Lys Glu Tyr Ala Phe Phe 
                165                 170                 175     


Tyr Lys Leu Asp Ile Ile Pro Ile Asp Asn Asp Thr Thr Ser Tyr Lys 
            180                 185                 190         


Leu Thr Ser Cys Asn Thr Ser Val Ile Thr Gln Ala Cys Pro Lys Val 
        195                 200                 205             


Ser Phe Glu Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Phe Ala 
    210                 215                 220                 


Ile Leu Lys Cys Asn Asn Lys Thr Phe Asn Gly Thr Gly Pro Cys Thr 
225                 230                 235                 240 


Asn Val Ser Thr Val Gln Cys Thr His Gly Ile Arg Pro Val Val Ser 
                245                 250                 255     


Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile 
            260                 265                 270         


Arg Ser Val Asn Phe Thr Asp Asn Ala Lys Thr Ile Ile Val Gln Leu 
        275                 280                 285             


Asn Thr Ser Val Glu Ile Asn Cys Thr Arg Pro Asn Asn Asn Thr Arg 
    290                 295                 300                 


Lys Arg Ile Arg Ile Gln Arg Gly Pro Gly Arg Ala Phe Val Thr Ile 
305                 310                 315                 320 


Gly Lys Ile Gly Asn Met Arg Gln Ala His Cys Asn Ile Ser Arg Ala 
                325                 330                 335     


Lys Trp Asn Asn Thr Leu Lys Gln Ile Ala Ser Lys Leu Arg Glu Gln 
            340                 345                 350         


Phe Gly Asn Asn Lys Thr Ile Ile Phe Lys Gln Ser Ser Gly Gly Asp 
        355                 360                 365             


Pro Glu Ile Val Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr 
    370                 375                 380                 


Cys Asn Ser Thr Gln Leu Phe Asn Ser Thr Trp Phe Asn Ser Thr Trp 
385                 390                 395                 400 


Ser Thr Glu Gly Ser Asn Asn Thr Glu Gly Ser Asp Thr Ile Thr Leu 
                405                 410                 415     


Pro Cys Arg Ile Lys Gln Ile Ile Asn Met Trp Gln Lys Val Gly Lys 
            420                 425                 430         


Ala Met Tyr Ala Pro Pro Ile Ser Gly Gln Ile Arg Cys Ser Ser Asn 
        435                 440                 445             


Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly Asn Ser Asn Asn Glu 
    450                 455                 460                 


Ser Glu Ile Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Asn Trp Arg 
465                 470                 475                 480 


Ser Glu Leu Tyr Lys Tyr Lys Val Val Lys Ile Glu Pro Leu Gly Val 
                485                 490                 495     


Ala Pro Thr Lys Ala Lys Arg Arg Val Val Gln Arg Glu Lys Arg Ala 
            500                 505                 510         


Val Gly Ile Gly Ala Leu Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser 
        515                 520                 525             


Thr Met Gly Ala Ala Ser Met Thr Leu Thr Val Gln Ala Arg Gln Leu 
    530                 535                 540                 


Leu Ser Gly Ile Val Gln Gln Gln Asn Asn Leu Leu Arg Ala Ile Glu 
545                 550                 555                 560 


Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu 
                565                 570                 575     


Gln Ala Arg Ile Leu Ala Val Glu Arg Tyr Leu Lys Asp Gln Gln Leu 
            580                 585                 590         


Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys Thr Thr Ala Val 
        595                 600                 605             


Pro Trp Asn Ala Ser Trp Ser Asn Lys Ser Leu Glu Gln Ile Trp Asn 
    610                 615                 620                 


His Thr Thr Trp Met Glu Trp Asp Arg Glu Ile Asn Asn Tyr Thr Ser 
625                 630                 635                 640 


Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn 
                645                 650                 655     


Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp 
            660                 665                 670         


Phe Asn Ile Thr Asn Trp Leu Trp Tyr Ile Lys Leu Phe Ile Met Ile 
        675                 680                 685             


Val Gly Gly Leu Val Gly Leu Arg Ile Val Phe Ala Val Leu Ser Ile 
    690                 695                 700                 


Val Asn Arg Val Arg Gln Gly Tyr Ser Pro Leu Ser Phe Gln Thr His 
705                 710                 715                 720 


Leu Pro Thr Pro Arg Gly Pro Asp Arg Pro Glu Gly Ile Glu Glu Glu 
                725                 730                 735     


Gly Gly Glu Arg Asp Arg Asp Arg Ser Ile Arg Leu Val Asn Gly Ser 
            740                 745                 750         


Leu Ala Leu Ile Trp Asp Asp Leu Arg Ser Leu Cys Leu Phe Ser Tyr 
        755                 760                 765             


His Arg Leu Arg Asp Leu Leu Leu Ile Val Thr Arg Ile Val Glu Leu 
    770                 775                 780                 


Leu Gly Arg Arg Gly Trp Glu Ala Leu Lys Tyr Trp Trp Asn Leu Leu 
785                 790                 795                 800 


Gln Tyr Trp Ser Gln Glu Leu Lys Asn Ser Ala Val Ser Leu Leu Asn 
                805                 810                 815     


Ala Thr Ala Ile Ala Val Ala Glu Gly Thr Asp Arg Val Ile Glu Val 
            820                 825                 830         


Val Gln Gly Ala Cys Arg Ala Ile Arg His Ile Pro Arg Arg Ile Arg 
        835                 840                 845             


Gln Gly Leu Glu Arg Ile Leu Leu 
    850                 855     


<210>  3
<211>  606
<212>  PRT
<213>  Avian leukosis virus

<400>  3

Met Glu Ala Val Ile Lys Ala Phe Leu Thr Gly Tyr Pro Gly Lys Thr 
1               5                   10                  15      


Ser Lys Lys Asp Ser Lys Glu Lys Pro Leu Ala Thr Ser Lys Lys Asp 
            20                  25                  30          


Pro Glu Lys Thr Pro Leu Leu Pro Thr Arg Val Asn Tyr Ile Leu Ile 
        35                  40                  45              


Ile Gly Val Leu Val Leu Cys Glu Val Thr Gly Val Arg Ala Asp Val 
    50                  55                  60                  


His Leu Leu Glu Gln Pro Gly Asn Leu Trp Ile Thr Trp Ala Asn Arg 
65                  70                  75                  80  


Thr Gly Gln Thr Asp Phe Cys Leu Ser Thr Gln Ser Ala Thr Ser Pro 
                85                  90                  95      


Phe Gln Thr Cys Leu Ile Gly Ile Pro Ser Pro Ile Ser Glu Gly Asp 
            100                 105                 110         


Phe Lys Gly Tyr Val Ser Asp Asn Cys Thr Thr Leu Gly Thr Asp Arg 
        115                 120                 125             


Leu Val Ser Ser Ala Asp Phe Thr Gly Gly Pro Asp Asn Ser Thr Thr 
    130                 135                 140                 


Leu Thr Tyr Arg Lys Val Ser Cys Leu Leu Leu Lys Leu Asn Val Ser 
145                 150                 155                 160 


Met Trp Asp Glu Pro His Glu Leu Gln Leu Leu Gly Ser Gln Ser Leu 
                165                 170                 175     


Pro Asn Ile Thr Asn Ile Ala Gln Ile Ser Gly Ile Thr Gly Gly Cys 
            180                 185                 190         


Val Gly Phe Arg Pro Gln Gly Val Pro Trp Tyr Leu Gly Trp Ser Arg 
        195                 200                 205             


Gln Glu Ala Thr Arg Phe Leu Leu Arg His Pro Ser Phe Ser Lys Ser 
    210                 215                 220                 


Thr Glu Pro Phe Thr Val Val Thr Ala Asp Arg His Asn Leu Phe Met 
225                 230                 235                 240 


Gly Ser Glu Tyr Cys Gly Ala Tyr Gly Tyr Arg Phe Trp Asn Met Tyr 
                245                 250                 255     


Asn Cys Ser Gln Val Gly Arg Gln Tyr Arg Cys Gly Asn Ala Arg Ser 
            260                 265                 270         


Pro Arg Pro Gly Leu Pro Glu Ile Gln Cys Thr Arg Arg Gly Gly Lys 
        275                 280                 285             


Trp Val Asn Gln Ser Gln Glu Ile Asn Glu Ser Glu Pro Phe Ser Phe 
    290                 295                 300                 


Thr Val Asn Cys Thr Ala Ser Ser Leu Gly Asn Ala Ser Gly Cys Cys 
305                 310                 315                 320 


Gly Lys Ala Gly Thr Ile Leu Pro Gly Lys Trp Val Asp Ser Thr Gln 
                325                 330                 335     


Gly Ser Phe Thr Lys Pro Lys Ala Leu Pro Pro Ala Ile Phe Leu Ile 
            340                 345                 350         


Cys Gly Asp Arg Ala Trp Gln Gly Ile Pro Ser Arg Pro Val Gly Gly 
        355                 360                 365             


Pro Cys Tyr Leu Gly Lys Leu Thr Met Leu Ala Pro Lys His Thr Asp 
    370                 375                 380                 


Ile Leu Lys Val Leu Val Asn Ser Ser Arg Thr Gly Ile Arg Arg Lys 
385                 390                 395                 400 


Arg Ser Thr Ser His Leu Asp Asp Thr Cys Ser Asp Glu Val Gln Leu 
                405                 410                 415     


Trp Gly Pro Thr Ala Arg Ile Phe Ala Ser Ile Leu Ala Pro Gly Val 
            420                 425                 430         


Ala Ala Ala Gln Ala Leu Arg Glu Ile Glu Arg Leu Ala Cys Trp Ser 
        435                 440                 445             


Val Lys Gln Ala Asn Leu Thr Thr Ser Leu Leu Gly Asp Leu Leu Asp 
    450                 455                 460                 


Asp Val Thr Ser Ile Arg His Ala Val Leu Gln Asn Arg Ala Ala Ile 
465                 470                 475                 480 


Asp Phe Leu Leu Leu Ala His Gly His Gly Cys Glu Asp Val Ala Gly 
                485                 490                 495     


Met Cys Cys Phe Asn Leu Ser Asp His Ser Glu Ser Ile Gln Lys Lys 
            500                 505                 510         


Phe Gln Leu Met Lys Glu His Val Asn Lys Ile Gly Val Asp Ser Asp 
        515                 520                 525             


Pro Ile Gly Ser Trp Leu Arg Gly Leu Phe Gly Gly Ile Gly Glu Trp 
    530                 535                 540                 


Ala Val His Leu Leu Lys Gly Leu Leu Leu Gly Leu Val Val Ile Leu 
545                 550                 555                 560 


Leu Leu Val Val Cys Leu Pro Cys Leu Leu Gln Ile Val Cys Gly Asn 
                565                 570                 575     


Ile Arg Lys Met Ile Asn Asn Ser Ile Ser Tyr His Thr Glu Tyr Lys 
            580                 585                 590         


Lys Leu Gln Lys Ala Cys Gly Gln Pro Glu Ser Arg Ile Val 
        595                 600                 605     


<210>  4
<211>  601
<212>  PRT
<213>  Rous Sarcoma Virus

<400>  4

Met Glu Ala Val Ile Lys Ala Phe Leu Thr Gly Tyr Pro Gly Lys Thr 
1               5                   10                  15      


Ser Lys Lys Asp Ser Lys Glu Lys Pro Leu Ala Thr Ser Lys Lys Asp 
            20                  25                  30          


Pro Glu Lys Thr Pro Leu Leu Pro Thr Arg Val Asn Tyr Ile Leu Ile 
        35                  40                  45              


Ile Gly Val Leu Val Leu Cys Glu Val Thr Gly Val Arg Ala Asp Val 
    50                  55                  60                  


His Leu Leu Glu Gln Pro Gly Asn Leu Trp Ile Thr Trp Ala Asn Arg 
65                  70                  75                  80  


Thr Gly Gln Thr Asp Phe Cys Leu Ser Thr Gln Ser Ala Thr Ser Pro 
                85                  90                  95      


Phe Gln Thr Cys Leu Ile Gly Ile Pro Ser Pro Ile Ser Glu Gly Asp 
            100                 105                 110         


Phe Lys Gly Tyr Val Ser Asp Thr Asn Cys Ser Thr Val Gly Thr Asp 
        115                 120                 125             


Arg Leu Val Leu Ser Ala Ser Ile Thr Gly Gly Pro Asp Asn Ser Thr 
    130                 135                 140                 


Thr Leu Thr Tyr Arg Lys Val Ser Cys Leu Leu Leu Lys Leu Asn Val 
145                 150                 155                 160 


Ser Met Trp Asp Glu Pro Pro Glu Leu Gln Leu Leu Gly Ser Gln Ser 
                165                 170                 175     


Leu Pro Asn Val Thr Asn Ile Thr Gln Val Ser Gly Val Ala Gly Gly 
            180                 185                 190         


Cys Val Tyr Phe Ala Pro Arg Ala Thr Gly Leu Phe Leu Gly Trp Ser 
        195                 200                 205             


Lys Gln Gly Leu Ser Arg Phe Leu Leu Arg His Pro Phe Thr Ser Thr 
    210                 215                 220                 


Ser Asn Ser Thr Glu Pro Phe Thr Val Val Thr Ala Asp Arg His Asn 
225                 230                 235                 240 


Leu Phe Met Gly Ser Glu Tyr Cys Gly Ala Tyr Gly Tyr Arg Phe Trp 
                245                 250                 255     


Glu Ile Tyr Asn Cys Ser Gln Thr Arg Asn Thr Tyr Arg Cys Gly Asp 
            260                 265                 270         


Val Gly Gly Thr Gly Leu Pro Glu Thr Trp Cys Arg Gly Lys Gly Gly 
        275                 280                 285             


Ile Trp Val Asn Gln Ser Lys Glu Ile Asn Glu Thr Glu Pro Phe Ser 
    290                 295                 300                 


Phe Thr Ala Asn Cys Thr Gly Ser Asn Leu Gly Asn Val Ser Gly Cys 
305                 310                 315                 320 


Cys Gly Glu Pro Ile Thr Ile Leu Pro Leu Gly Ala Trp Ile Asp Ser 
                325                 330                 335     


Thr Gln Gly Ser Phe Thr Lys Pro Lys Ala Leu Pro Pro Ala Ile Phe 
            340                 345                 350         


Leu Ile Cys Gly Asp Arg Ala Trp Gln Gly Ile Pro Ser Arg Pro Val 
        355                 360                 365             


Gly Gly Pro Cys Tyr Leu Gly Lys Leu Thr Met Leu Ala Pro Asn His 
    370                 375                 380                 


Thr Asp Ile Leu Lys Ile Leu Ala Asn Ser Ser Arg Thr Gly Ile Arg 
385                 390                 395                 400 


Arg Lys Arg Ser Val Ser His Leu Asp Asp Thr Cys Ser Asp Glu Val 
                405                 410                 415     


Gln Leu Trp Gly Pro Thr Ala Arg Ile Phe Ala Ser Ile Leu Ala Pro 
            420                 425                 430         


Gly Val Ala Ala Ala Gln Ala Leu Arg Glu Ile Glu Arg Leu Ala Cys 
        435                 440                 445             


Trp Ser Val Lys Gln Ala Asn Leu Thr Thr Ser Leu Leu Gly Asp Leu 
    450                 455                 460                 


Leu Asp Asp Val Thr Ser Ile Arg His Ala Val Leu Gln Asn Arg Ala 
465                 470                 475                 480 


Ala Ile Asp Phe Leu Leu Leu Ala His Gly His Gly Cys Glu Asp Val 
                485                 490                 495     


Ala Gly Met Cys Cys Phe Asn Leu Ser Asp His Ser Glu Ser Ile Gln 
            500                 505                 510         


Lys Lys Phe Gln Leu Met Lys Lys His Val Asn Lys Ile Gly Val Asp 
        515                 520                 525             


Ser Asp Pro Ile Gly Ser Trp Leu Arg Gly Ile Phe Gly Gly Ile Gly 
    530                 535                 540                 


Glu Trp Ala Val His Leu Leu Lys Gly Leu Leu Leu Gly Leu Val Val 
545                 550                 555                 560 


Ile Leu Leu Leu Leu Val Cys Leu Pro Cys Leu Leu Gln Phe Val Ser 
                565                 570                 575     


Ser Ser Ile Arg Lys Met Ile Asn Ser Ser Ile Asn Tyr His Thr Glu 
            580                 585                 590         


Tyr Arg Lys Met Gln Gly Gly Ala Val 
        595                 600     


<210>  5
<211>  688
<212>  PRT
<213>  Mouse mammary tumor virus

<400>  5

Met Pro Lys His Gln Ser Gly Ser Pro Thr Asp Ser Ser Asp Leu Leu 
1               5                   10                  15      


Leu Ser Gly Lys Lys Gln Arg Pro His Leu Ala Leu Arg Arg Lys Arg 
            20                  25                  30          


Arg Arg Glu Met Arg Lys Ile Asn Arg Lys Val Pro Arg Met Asn Leu 
        35                  40                  45              


Val Pro Ile Lys Glu Lys Thr Ala Trp Gln His Leu Gln Ala Leu Ile 
    50                  55                  60                  


Ser Glu Ala Glu Glu Val Leu Lys Thr Ser Gln Thr Pro Gln Thr Ser 
65                  70                  75                  80  


Leu Thr Leu Phe Leu Ala Leu Leu Ser Val Leu Gly Pro Pro Pro Val 
                85                  90                  95      


Thr Gly Glu Ser Tyr Trp Ala Tyr Leu Pro Lys Pro Pro Ile Leu His 
            100                 105                 110         


Pro Val Gly Trp Gly Ser Thr Asp Pro Ile Arg Val Leu Thr Asn Gln 
        115                 120                 125             


Thr Met Tyr Leu Gly Gly Ser Pro Asp Phe His Gly Phe Arg Asn Met 
    130                 135                 140                 


Ser Gly Asn Val His Phe Glu Gly Lys Ser Asp Thr Leu Pro Ile Cys 
145                 150                 155                 160 


Leu Ser Phe Ser Phe Ser Thr Pro Thr Gly Cys Phe Gln Val Asp Lys 
                165                 170                 175     


Gln Val Phe Leu Ser Asp Thr Pro Thr Val Asp Asn Asn Lys Pro Gly 
            180                 185                 190         


Gly Lys Gly Asp Lys Arg Arg Met Trp Glu Leu Trp Leu Thr Thr Leu 
        195                 200                 205             


Gly Asn Ser Gly Ala Asn Thr Lys Leu Val Pro Ile Lys Lys Lys Leu 
    210                 215                 220                 


Pro Pro Lys Tyr Pro His Cys Gln Ile Ala Phe Lys Lys Asp Ala Phe 
225                 230                 235                 240 


Trp Glu Gly Asp Glu Ser Ala Pro Pro Arg Trp Leu Pro Cys Ala Phe 
                245                 250                 255     


Pro Asp Gln Gly Val Ser Phe Ser Pro Lys Gly Ala Leu Gly Leu Leu 
            260                 265                 270         


Trp Asp Phe Ser Leu Pro Ser Pro Ser Val Asp Gln Ser Asp Gln Ile 
        275                 280                 285             


Lys Ser Lys Lys Asn Leu Phe Gly Asn Tyr Thr Pro Pro Val Asn Lys 
    290                 295                 300                 


Glu Val His Arg Trp Tyr Glu Ala Gly Trp Val Glu Pro Thr Trp Phe 
305                 310                 315                 320 


Trp Glu Asn Ser Pro Lys Asp Pro Asn Asp Arg Asp Phe Thr Ala Leu 
                325                 330                 335     


Val Pro His Thr Glu Leu Phe Arg Leu Val Ala Ala Ser Arg His Leu 
            340                 345                 350         


Ile Leu Lys Arg Pro Gly Phe Gln Glu His Glu Met Ile Pro Thr Ser 
        355                 360                 365             


Ala Cys Val Thr Tyr Pro Tyr Ala Ile Leu Leu Gly Leu Pro Gln Leu 
    370                 375                 380                 


Ile Asp Ile Glu Lys Arg Gly Ser Thr Phe His Ile Ser Cys Ser Ser 
385                 390                 395                 400 


Cys Arg Leu Thr Asn Cys Leu Asp Ser Ser Ala Tyr Asp Tyr Ala Ala 
                405                 410                 415     


Ile Ile Val Lys Arg Pro Pro Tyr Val Leu Leu Pro Val Asp Ile Gly 
            420                 425                 430         


Asp Glu Pro Trp Phe Asp Asp Ser Ala Ile Gln Thr Phe Arg Tyr Ala 
        435                 440                 445             


Thr Asp Leu Ile Arg Ala Lys Arg Phe Val Ala Ala Ile Ile Leu Gly 
    450                 455                 460                 


Ile Ser Ala Leu Ile Ala Ile Ile Thr Ser Phe Ala Val Ala Thr Thr 
465                 470                 475                 480 


Ala Leu Val Lys Glu Met Gln Thr Ala Thr Phe Val Asn Asn Leu His 
                485                 490                 495     


Arg Asn Val Thr Leu Ala Leu Ser Glu Gln Arg Ile Ile Asp Leu Lys 
            500                 505                 510         


Leu Glu Ala Arg Leu Asn Ala Leu Glu Glu Val Val Leu Glu Leu Gly 
        515                 520                 525             


Gln Asp Val Ala Asn Leu Lys Thr Arg Met Ser Thr Arg Cys His Ala 
    530                 535                 540                 


Asn Tyr Asp Phe Ile Cys Val Thr Pro Leu Pro Tyr Asn Ala Thr Glu 
545                 550                 555                 560 


Asn Trp Glu Arg Thr Arg Ala His Leu Leu Gly Ile Trp Asn Asp Asn 
                565                 570                 575     


Glu Ile Ser Tyr Asn Ile Gln Glu Leu Thr Asn Leu Ile Ser Asp Met 
            580                 585                 590         


Ser Lys Gln His Ile Asp Ala Val Asp Leu Ser Gly Leu Ala Gln Ser 
        595                 600                 605             


Phe Ala Asn Gly Val Lys Ala Leu Asn Pro Leu Asp Trp Thr Gln Tyr 
    610                 615                 620                 


Phe Ile Phe Ile Gly Val Gly Ala Leu Leu Leu Val Ile Val Leu Met 
625                 630                 635                 640 


Ile Phe Pro Ile Val Phe Gln Cys Leu Ala Lys Ser Leu Asp Gln Val 
                645                 650                 655     


Gln Ser Asp Leu Asn Val Leu Leu Leu Lys Lys Lys Lys Gly Gly Asn 
            660                 665                 670         


Ala Ala Pro Ala Ala Glu Met Val Glu Leu Pro Arg Val Ser Tyr Thr 
        675                 680                 685             


<210>  6
<211>  488
<212>  PRT
<213>  Human T-lymphotropic virus 1

<400>  6

Met Gly Lys Phe Leu Ala Thr Leu Ile Leu Phe Phe Gln Phe Cys Pro 
1               5                   10                  15      


Leu Ile Phe Gly Asp Tyr Ser Pro Ser Cys Cys Thr Leu Thr Ile Gly 
            20                  25                  30          


Val Ser Ser Tyr His Ser Lys Pro Cys Asn Pro Ala Gln Pro Val Cys 
        35                  40                  45              


Ser Trp Thr Leu Asp Leu Leu Ala Leu Ser Ala Asp Gln Ala Leu Gln 
    50                  55                  60                  


Pro Pro Cys Pro Asn Leu Val Ser Tyr Ser Ser Tyr His Ala Thr Tyr 
65                  70                  75                  80  


Ser Leu Tyr Leu Phe Pro His Trp Thr Lys Lys Pro Asn Arg Asn Gly 
                85                  90                  95      


Gly Gly Tyr Tyr Ser Ala Ser Tyr Ser Asp Pro Cys Ser Leu Lys Cys 
            100                 105                 110         


Pro Tyr Leu Gly Cys Gln Ser Trp Thr Cys Pro Tyr Thr Gly Ala Val 
        115                 120                 125             


Ser Ser Pro Tyr Trp Lys Phe Gln His Asp Val Asn Phe Thr Gln Glu 
    130                 135                 140                 


Val Ser Arg Leu Asn Ile Asn Leu His Phe Ser Lys Cys Gly Phe Pro 
145                 150                 155                 160 


Phe Ser Leu Leu Val Asp Ala Pro Gly Tyr Asp Pro Ile Trp Phe Leu 
                165                 170                 175     


Asn Thr Glu Pro Ser Gln Leu Pro Pro Thr Ala Pro Pro Leu Leu Pro 
            180                 185                 190         


His Ser Asn Leu Asp His Ile Leu Glu Pro Ser Ile Pro Trp Lys Ser 
        195                 200                 205             


Lys Leu Leu Thr Leu Val Gln Leu Thr Leu Gln Ser Thr Asn Tyr Thr 
    210                 215                 220                 


Cys Ile Val Cys Ile Asp Arg Ala Ser Leu Ser Thr Trp His Val Leu 
225                 230                 235                 240 


Tyr Ser Pro Asn Val Ser Val Pro Ser Ser Ser Ser Thr Pro Leu Leu 
                245                 250                 255     


Tyr Pro Ser Leu Ala Leu Pro Ala Pro His Leu Thr Leu Pro Phe Asn 
            260                 265                 270         


Trp Thr His Cys Phe Asp Pro Gln Ile Gln Ala Ile Val Ser Ser Pro 
        275                 280                 285             


Cys His Asn Ser Leu Ile Leu Pro Pro Phe Ser Leu Ser Pro Val Pro 
    290                 295                 300                 


Thr Leu Gly Ser Arg Ser Arg Arg Ala Val Pro Val Ala Val Trp Leu 
305                 310                 315                 320 


Val Ser Ala Leu Ala Met Gly Ala Gly Val Ala Gly Gly Ile Thr Gly 
                325                 330                 335     


Ser Met Ser Leu Ala Ser Gly Lys Ser Leu Leu His Glu Val Asp Lys 
            340                 345                 350         


Asp Ile Ser Gln Leu Thr Gln Ala Ile Val Lys Asn His Lys Asn Leu 
        355                 360                 365             


Leu Lys Ile Ala Gln Tyr Ala Ala Gln Asn Arg Arg Gly Leu Asp Leu 
    370                 375                 380                 


Leu Phe Trp Glu Gln Gly Gly Leu Cys Lys Ala Leu Gln Glu Gln Cys 
385                 390                 395                 400 


Arg Phe Pro Asn Ile Thr Asn Ser His Val Pro Ile Leu Gln Glu Arg 
                405                 410                 415     


Pro Pro Leu Glu Asn Arg Val Leu Thr Gly Trp Gly Leu Asn Trp Asp 
            420                 425                 430         


Leu Gly Leu Ser Gln Trp Ala Arg Glu Ala Leu Gln Thr Gly Ile Thr 
        435                 440                 445             


Leu Val Ala Leu Leu Leu Leu Val Ile Leu Ala Gly Pro Cys Ile Leu 
    450                 455                 460                 


Arg Gln Leu Arg His Leu Pro Ser Arg Val Arg Tyr Pro His Tyr Ser 
465                 470                 475                 480 


Leu Ile Lys Pro Glu Ser Ser Leu 
                485             


<210>  7
<211>  565
<212>  PRT
<213>  RD114 Endogenous Feline Retrovirus

<400>  7

Met Lys Leu Pro Thr Gly Met Val Ile Leu Cys Ser Leu Ile Ile Val 
1               5                   10                  15      


Arg Ala Gly Phe Asp Asp Pro Arg Lys Ala Ile Ala Leu Val Gln Lys 
            20                  25                  30          


Gln His Gly Lys Pro Cys Glu Cys Ser Gly Gly Gln Val Ser Glu Ala 
        35                  40                  45              


Pro Pro Asn Ser Ile Gln Gln Val Thr Cys Pro Gly Lys Thr Ala Tyr 
    50                  55                  60                  


Leu Met Thr Asn Gln Lys Trp Lys Cys Arg Val Thr Pro Lys Asn Leu 
65                  70                  75                  80  


Thr Pro Ser Gly Gly Glu Leu Gln Asn Cys Pro Cys Asn Thr Phe Gln 
                85                  90                  95      


Asp Ser Met His Ser Ser Cys Tyr Thr Glu Tyr Arg Gln Cys Arg Ala 
            100                 105                 110         


Asn Asn Lys Thr Tyr Tyr Thr Ala Thr Leu Leu Lys Ile Arg Ser Gly 
        115                 120                 125             


Ser Leu Asn Glu Val Gln Ile Leu Gln Asn Pro Asn Gln Leu Leu Gln 
    130                 135                 140                 


Ser Pro Cys Arg Gly Ser Ile Asn Gln Pro Val Cys Trp Ser Ala Thr 
145                 150                 155                 160 


Ala Pro Ile His Ile Ser Asp Gly Gly Gly Pro Leu Asp Thr Lys Arg 
                165                 170                 175     


Val Trp Thr Val Gln Lys Arg Leu Glu Gln Ile His Lys Ala Met His 
            180                 185                 190         


Pro Glu Leu Gln Tyr His Pro Leu Ala Leu Pro Lys Val Arg Asp Asp 
        195                 200                 205             


Leu Ser Leu Asp Ala Arg Thr Phe Asp Ile Leu Asn Thr Thr Phe Arg 
    210                 215                 220                 


Leu Leu Gln Met Ser Asn Phe Ser Leu Ala Gln Asp Cys Trp Leu Cys 
225                 230                 235                 240 


Leu Lys Leu Gly Thr Pro Thr Pro Leu Ala Ile Pro Thr Pro Ser Leu 
                245                 250                 255     


Thr Tyr Ser Leu Ala Asp Ser Leu Ala Asn Ala Ser Cys Gln Ile Ile 
            260                 265                 270         


Pro Pro Leu Leu Val Gln Pro Met Gln Phe Ser Asn Ser Ser Cys Leu 
        275                 280                 285             


Ser Ser Pro Phe Ile Asn Asp Thr Glu Gln Ile Asp Leu Gly Ala Val 
    290                 295                 300                 


Thr Phe Thr Asn Cys Thr Ser Val Ala Asn Val Ser Ser Pro Leu Cys 
305                 310                 315                 320 


Ala Leu Asn Gly Ser Val Phe Leu Cys Gly Asn Asn Met Ala Tyr Thr 
                325                 330                 335     


Tyr Leu Pro Gln Asn Trp Thr Gly Leu Cys Val Gln Ala Ser Leu Leu 
            340                 345                 350         


Pro Asp Ile Asp Ile Ile Pro Gly Asp Glu Pro Val Pro Ile Pro Ala 
        355                 360                 365             


Ile Asp His Tyr Ile His Arg Pro Lys Arg Ala Val Gln Phe Ile Pro 
    370                 375                 380                 


Leu Leu Ala Gly Leu Gly Ile Thr Ala Ala Phe Thr Thr Gly Ala Thr 
385                 390                 395                 400 


Gly Leu Gly Val Ser Val Thr Gln Tyr Thr Lys Leu Ser His Gln Leu 
                405                 410                 415     


Ile Ser Asp Val Gln Val Leu Ser Gly Thr Ile Gln Asp Leu Gln Asp 
            420                 425                 430         


Gln Val Asp Ser Leu Ala Glu Val Val Leu Gln Asn Arg Arg Gly Leu 
        435                 440                 445             


Asp Leu Leu Thr Ala Glu Gln Gly Gly Ile Cys Leu Ala Leu Gln Glu 
    450                 455                 460                 


Lys Cys Cys Phe Tyr Ala Asn Lys Ser Gly Ile Val Arg Asn Lys Ile 
465                 470                 475                 480 


Arg Thr Leu Gln Glu Glu Leu Gln Lys Arg Arg Glu Ser Leu Ala Ser 
                485                 490                 495     


Asn Pro Leu Trp Thr Gly Leu Gln Gly Phe Leu Pro Tyr Leu Leu Pro 
            500                 505                 510         


Leu Leu Gly Pro Leu Leu Thr Leu Leu Leu Ile Leu Thr Ile Gly Pro 
        515                 520                 525             


Cys Val Phe Ser Arg Leu Met Ala Phe Ile Asn Asp Arg Leu Asn Val 
    530                 535                 540                 


Val His Ala Met Val Leu Ala Gln Gln Tyr Gln Ala Leu Lys Ala Glu 
545                 550                 555                 560 


Glu Glu Ala Gln Asp 
                565 


<210>  8
<211>  685
<212>  PRT
<213>  Gibbon ape leukemia virus

<400>  8

Met Val Leu Leu Pro Gly Ser Met Leu Leu Thr Ser Ser Leu His His 
1               5                   10                  15      


Leu Arg His Gln Met Ser Pro Gly Ser Trp Lys Arg Leu Ile Ile Leu 
            20                  25                  30          


Leu Ser Cys Val Phe Gly Gly Gly Gly Thr Ser Leu Gln Asn Lys Asn 
        35                  40                  45              


Pro His Gln Pro Met Thr Leu Thr Trp Gln Val Leu Ser Gln Thr Gly 
    50                  55                  60                  


Asp Val Val Trp Asp Thr Lys Ala Val Gln Pro Pro Trp Thr Trp Trp 
65                  70                  75                  80  


Pro Thr Leu Lys Pro Asp Ile Cys Ala Leu Ala Ala Gly Leu Glu Ser 
                85                  90                  95      


Trp Asp Ile Pro Gly Thr Asp Val Ser Ser Ser Lys Arg Val Arg Pro 
            100                 105                 110         


Pro Asp Ser Asp Tyr Thr Ala Ala Tyr Lys Gln Ile Thr Trp Gly Ala 
        115                 120                 125             


Ile Gly Cys Ser Tyr Pro Arg Ala Arg Thr Arg Met Ala Ser Ser Thr 
    130                 135                 140                 


Phe Tyr Val Cys Pro Arg Asp Gly Arg Thr Pro Ser Glu Ala Arg Arg 
145                 150                 155                 160 


Cys Gly Gly Leu Glu Ser Leu Tyr Cys Lys Glu Trp Asn Cys Glu Thr 
                165                 170                 175     


Thr Gly Thr Gly Tyr Trp Leu Pro Lys Ser Ser Lys Asp Leu Ile Thr 
            180                 185                 190         


Gly Arg Trp Asp Gln Asn Ser Lys Trp Asp Gln Lys Phe Gln Lys Cys 
        195                 200                 205             


His Gln Thr Gly Trp Cys Asn Pro Leu Lys Ile Asp Phe Thr Asp Thr 
    210                 215                 220                 


Gly Lys Ser Ser Arg Asp Trp Ile Val Gly Lys Thr Trp Gly Leu Arg 
225                 230                 235                 240 


Phe Tyr Val His Gly His Pro Gly Val Gln Phe Thr Ile Arg Leu Lys 
                245                 250                 255     


Ile Thr Ser Met Thr Ala Val Ala Val Gly Pro Asp Pro Val Leu Val 
            260                 265                 270         


Glu Gln Gly Pro Pro Arg Arg Ala Leu Ala Leu Pro Pro Pro Leu Pro 
        275                 280                 285             


Pro Arg Glu Ala Pro Pro Pro Pro Leu Pro Asp Ser Asn Ser Thr Thr 
    290                 295                 300                 


Leu Ala Thr Ser Ala Gln Thr Pro Thr Val Gly Lys Thr Ile Val Thr 
305                 310                 315                 320 


Leu Asn Thr Pro Pro Pro Thr Thr Gly Asp Arg Leu Phe Asn Leu Val 
                325                 330                 335     


Gln Gly Ala Phe Leu Thr Leu Asn Ala Thr Asn Pro Gly Ala Thr Lys 
            340                 345                 350         


Ser Cys Trp Leu Cys Leu Ala Met Gly Pro Pro Tyr Tyr Glu Ala Ile 
        355                 360                 365             


Thr Ser Leu Gly Glu Val Ala Tyr Ser Thr Ser Gln Asp Arg Cys His 
    370                 375                 380                 


Trp Gly Thr Gln Gly Lys Leu Thr Leu Thr Glu Val Ser Gly His Gly 
385                 390                 395                 400 


Leu Cys Ile Gly Lys Val Pro Phe Thr His Gln His Leu Cys Asn Gln 
                405                 410                 415     


Thr Leu Ser Ile Asn Ser Ser Glu Gly His Gln Tyr Leu Leu Pro Ser 
            420                 425                 430         


Asn His Ser Trp Trp Ala Cys Ser Thr Gly Leu Thr Pro Cys Leu Ser 
        435                 440                 445             


Thr Ser Val Phe Asn Gln Ser Arg Asp Phe Cys Ile Gln Val Gln Leu 
    450                 455                 460                 


Ile Pro Arg Ile Tyr Tyr Tyr Pro Glu Glu Val Leu Leu Gln Ala Tyr 
465                 470                 475                 480 


Asp Asp Ser His Pro Arg Pro Lys Arg Glu Ala Val Ser Leu Thr Leu 
                485                 490                 495     


Ala Val Leu Leu Gly Leu Gly Ile Thr Ala Gly Ile Gly Thr Gly Ser 
            500                 505                 510         


Thr Ala Leu Ile Lys Gly Pro Ile Asp Leu Gln Gln Gly Leu Thr Ser 
        515                 520                 525             


Leu Gln Ile Ala Ile Asp Ala Asp Leu Arg Ala Leu Gln Asp Ser Val 
    530                 535                 540                 


Ser Lys Leu Glu Asp Ser Leu Thr Ser Leu Ser Glu Val Val Leu Gln 
545                 550                 555                 560 


Asn Arg Arg Gly Leu Asp Leu Leu Phe Leu Lys Glu Gly Gly Leu Cys 
                565                 570                 575     


Ala Ala Leu Lys Glu Glu Cys Cys Phe Tyr Ile Asp His Ser Gly Ala 
            580                 585                 590         


Val Arg Asp Ser Met Lys Lys Leu Lys Glu Lys Leu Asp Lys Arg Gln 
        595                 600                 605             


Leu Glu Arg Gln Lys Asn Gln Asn Trp Tyr Glu Gly Trp Phe Asn Asn 
    610                 615                 620                 


Ser Pro Trp Phe Thr Thr Leu Leu Ser Thr Ile Ala Gly Pro Leu Leu 
625                 630                 635                 640 


Leu Leu Leu Leu Leu Leu Ile Leu Gly Pro Cys Ile Ile Asn Lys Leu 
                645                 650                 655     


Val Gln Phe Ile Asn Asp Arg Val Ser Ala Val Lys Ile Leu Val Leu 
            660                 665                 670         


Arg Thr Lys Tyr Gln Ala Leu Asp Asn Glu Asp Asn Leu 
        675                 680                 685 


<210>  9
<211>  665
<212>  PRT
<213>  Moloney Murine leukemia virus

<400>  9

Met Ala Arg Ser Thr Leu Ser Lys Pro Leu Lys Asn Lys Val Asn Pro 
1               5                   10                  15      


Arg Gly Pro Leu Ile Pro Leu Ile Leu Leu Met Leu Arg Gly Val Ser 
            20                  25                  30          


Thr Ala Ser Pro Gly Ser Ser Pro His Gln Val Tyr Asn Ile Thr Trp 
        35                  40                  45              


Glu Val Thr Asn Gly Asp Arg Glu Thr Val Trp Ala Thr Ser Gly Asn 
    50                  55                  60                  


His Pro Leu Trp Thr Trp Trp Pro Asp Leu Thr Pro Asp Leu Cys Met 
65                  70                  75                  80  


Leu Ala His His Gly Pro Ser Tyr Trp Gly Leu Glu Tyr Gln Ser Pro 
                85                  90                  95      


Phe Ser Ser Pro Pro Gly Pro Pro Cys Cys Ser Gly Gly Ser Ser Pro 
            100                 105                 110         


Gly Cys Ser Arg Asp Cys Glu Glu Pro Leu Thr Ser Leu Thr Pro Arg 
        115                 120                 125             


Cys Asn Thr Ala Trp Asn Arg Leu Lys Leu Asp Gln Thr Thr His Lys 
    130                 135                 140                 


Ser Asn Glu Gly Phe Tyr Val Cys Pro Gly Pro His Arg Pro Arg Glu 
145                 150                 155                 160 


Ser Lys Ser Cys Gly Gly Pro Asp Ser Phe Tyr Cys Ala Tyr Trp Gly 
                165                 170                 175     


Cys Glu Thr Thr Gly Arg Ala Tyr Trp Lys Pro Ser Ser Ser Trp Asp 
            180                 185                 190         


Phe Ile Thr Val Asn Asn Asn Leu Thr Ser Asp Gln Ala Val Gln Val 
        195                 200                 205             


Cys Lys Asp Asn Lys Trp Cys Asn Pro Leu Val Ile Arg Phe Thr Asp 
    210                 215                 220                 


Ala Gly Arg Arg Val Thr Ser Trp Thr Thr Gly His Tyr Trp Gly Leu 
225                 230                 235                 240 


Arg Leu Tyr Val Ser Gly Gln Asp Pro Gly Leu Thr Phe Gly Ile Arg 
                245                 250                 255     


Leu Arg Tyr Gln Asn Leu Gly Pro Arg Val Pro Ile Gly Pro Asn Pro 
            260                 265                 270         


Val Leu Ala Asp Gln Gln Pro Leu Ser Lys Pro Lys Pro Val Lys Ser 
        275                 280                 285             


Pro Ser Val Thr Lys Pro Pro Ser Gly Thr Pro Leu Ser Pro Thr Gln 
    290                 295                 300                 


Leu Pro Pro Ala Gly Thr Glu Asn Arg Leu Leu Asn Leu Val Asp Gly 
305                 310                 315                 320 


Ala Tyr Gln Ala Leu Asn Leu Thr Ser Pro Asp Lys Thr Gln Glu Cys 
                325                 330                 335     


Trp Leu Cys Leu Val Ala Gly Pro Pro Tyr Tyr Glu Gly Val Ala Val 
            340                 345                 350         


Leu Gly Thr Tyr Ser Asn His Thr Ser Ala Pro Ala Asn Cys Ser Val 
        355                 360                 365             


Ala Ser Gln His Lys Leu Thr Leu Ser Glu Val Thr Gly Gln Gly Leu 
    370                 375                 380                 


Cys Ile Gly Ala Val Pro Lys Thr His Gln Ala Leu Cys Asn Thr Thr 
385                 390                 395                 400 


Gln Thr Ser Ser Arg Gly Ser Tyr Tyr Leu Val Ala Pro Thr Gly Thr 
                405                 410                 415     


Met Trp Ala Cys Ser Thr Gly Leu Thr Pro Cys Ile Ser Thr Thr Ile 
            420                 425                 430         


Leu Asn Leu Thr Thr Asp Tyr Cys Val Leu Val Glu Leu Trp Pro Arg 
        435                 440                 445             


Val Thr Tyr His Ser Pro Ser Tyr Val Tyr Gly Leu Phe Glu Arg Ser 
    450                 455                 460                 


Asn Arg His Lys Arg Glu Pro Val Ser Leu Thr Leu Ala Leu Leu Leu 
465                 470                 475                 480 


Gly Gly Leu Thr Met Gly Gly Ile Ala Ala Gly Ile Gly Thr Gly Thr 
                485                 490                 495     


Thr Ala Leu Met Ala Thr Gln Gln Phe Gln Gln Leu Gln Ala Ala Val 
            500                 505                 510         


Gln Asp Asp Leu Arg Glu Val Glu Lys Ser Ile Ser Asn Leu Glu Lys 
        515                 520                 525             


Ser Leu Thr Ser Leu Ser Glu Val Val Leu Gln Asn Arg Arg Gly Leu 
    530                 535                 540                 


Asp Leu Leu Phe Leu Lys Glu Gly Gly Leu Cys Ala Ala Leu Lys Glu 
545                 550                 555                 560 


Glu Cys Cys Phe Tyr Ala Asp His Thr Gly Leu Val Arg Asp Ser Met 
                565                 570                 575     


Ala Lys Leu Arg Glu Arg Leu Asn Gln Arg Gln Lys Leu Phe Glu Ser 
            580                 585                 590         


Thr Gln Gly Trp Phe Glu Gly Leu Phe Asn Arg Ser Pro Trp Phe Thr 
        595                 600                 605             


Thr Leu Ile Ser Thr Ile Met Gly Pro Leu Ile Val Leu Leu Met Ile 
    610                 615                 620                 


Leu Leu Phe Gly Pro Cys Ile Leu Asn Arg Leu Val Gln Phe Val Lys 
625                 630                 635                 640 


Asp Arg Ile Ser Val Val Gln Ala Leu Val Leu Thr Gln Gln Tyr His 
                645                 650                 655     


Gln Leu Lys Pro Ile Glu Tyr Glu Pro 
            660                 665 


<210>  10
<211>  563
<212>  PRT
<213>  Baboon Endogenous Virus

<400>  10

Met Gly Phe Thr Thr Lys Ile Ile Phe Leu Tyr Asn Leu Val Leu Val 
1               5                   10                  15      


Tyr Ala Gly Phe Asp Asp Pro Arg Lys Ala Ile Glu Leu Val Gln Lys 
            20                  25                  30          


Arg Tyr Gly Arg Pro Cys Asp Cys Ser Gly Gly Gln Val Ser Glu Pro 
        35                  40                  45              


Pro Ser Asp Arg Val Ser Gln Val Thr Cys Ser Gly Lys Thr Ala Tyr 
    50                  55                  60                  


Leu Met Pro Asp Gln Arg Trp Lys Cys Lys Ser Ile Pro Lys Asp Thr 
65                  70                  75                  80  


Ser Pro Ser Gly Pro Leu Gln Glu Cys Pro Cys Asn Ser Tyr Gln Ser 
                85                  90                  95      


Ser Val His Ser Ser Cys Tyr Thr Ser Tyr Gln Gln Cys Arg Ser Gly 
            100                 105                 110         


Asn Lys Thr Tyr Tyr Thr Ala Thr Leu Leu Lys Thr Gln Thr Gly Gly 
        115                 120                 125             


Thr Ser Asp Val Gln Val Leu Gly Ser Thr Asn Lys Leu Ile Gln Ser 
    130                 135                 140                 


Pro Cys Asn Gly Ile Lys Gly Gln Ser Ile Cys Trp Ser Thr Thr Ala 
145                 150                 155                 160 


Pro Ile His Val Ser Asp Gly Gly Gly Pro Leu Asp Thr Thr Arg Ile 
                165                 170                 175     


Lys Ser Val Gln Arg Lys Leu Glu Glu Ile His Lys Ala Leu Tyr Pro 
            180                 185                 190         


Glu Leu Gln Tyr His Pro Leu Ala Ile Pro Lys Val Arg Asp Asn Leu 
        195                 200                 205             


Met Val Asp Ala Gln Thr Leu Asn Ile Leu Asn Ala Thr Tyr Asn Leu 
    210                 215                 220                 


Leu Leu Met Ser Asn Thr Ser Leu Val Asp Asp Cys Trp Leu Cys Leu 
225                 230                 235                 240 


Lys Leu Gly Pro Pro Thr Pro Leu Ala Ile Pro Asn Phe Leu Leu Ser 
                245                 250                 255     


Tyr Val Thr Arg Ser Ser Asp Asn Ile Ser Cys Leu Ile Ile Pro Pro 
            260                 265                 270         


Leu Leu Val Gln Pro Met Gln Phe Ser Asn Ser Ser Cys Leu Phe Ser 
        275                 280                 285             


Pro Ser Tyr Asn Ser Thr Glu Glu Ile Asp Leu Gly His Val Ala Phe 
    290                 295                 300                 


Ser Asn Cys Thr Ser Ile Thr Asn Val Thr Gly Pro Ile Cys Ala Val 
305                 310                 315                 320 


Asn Gly Ser Val Phe Leu Cys Gly Asn Asn Met Ala Tyr Thr Tyr Leu 
                325                 330                 335     


Pro Thr Asn Trp Thr Gly Leu Cys Val Leu Ala Thr Leu Leu Pro Asp 
            340                 345                 350         


Ile Asp Ile Ile Pro Gly Asp Glu Pro Val Pro Ile Pro Ala Ile Asp 
        355                 360                 365             


His Phe Ile Tyr Arg Pro Lys Arg Ala Ile Gln Phe Ile Pro Leu Leu 
    370                 375                 380                 


Ala Gly Leu Gly Ile Thr Ala Ala Phe Thr Thr Gly Ala Thr Gly Leu 
385                 390                 395                 400 


Gly Val Ser Val Thr Gln Tyr Thr Lys Leu Ser Asn Gln Leu Ile Ser 
                405                 410                 415     


Asp Val Gln Ile Leu Ser Ser Thr Ile Gln Asp Leu Gln Asp Gln Val 
            420                 425                 430         


Asp Ser Leu Ala Glu Val Val Leu Gln Asn Arg Arg Gly Leu Asp Leu 
        435                 440                 445             


Leu Thr Ala Glu Gln Gly Gly Ile Cys Leu Ala Leu Gln Glu Lys Cys 
    450                 455                 460                 


Cys Phe Tyr Val Asn Lys Ser Gly Ile Val Arg Asp Lys Ile Lys Thr 
465                 470                 475                 480 


Leu Gln Glu Glu Leu Glu Arg Arg Arg Lys Asp Leu Ala Ser Asn Pro 
                485                 490                 495     


Leu Trp Thr Gly Leu Gln Gly Leu Leu Pro Tyr Leu Leu Pro Phe Leu 
            500                 505                 510         


Gly Pro Leu Leu Thr Leu Leu Leu Leu Leu Thr Ile Gly Pro Cys Ile 
        515                 520                 525             


Phe Asn Arg Leu Thr Ala Phe Ile Asn Asp Lys Leu Asn Ile Ile His 
    530                 535                 540                 


Ala Met Val Leu Thr Gln Gln Tyr Gln Val Leu Arg Thr Asp Glu Glu 
545                 550                 555                 560 


Ala Gln Asp 
            


<210>  11
<211>  985
<212>  PRT
<213>  Human Foamy Virus

<400>  11

Met Thr Leu Gln Gln Trp Ile Ile Trp Lys Lys Met Asn Lys Ala His 
1               5                   10                  15      


Glu Ala Leu Gln Asn Thr Thr Thr Val Thr Glu Gln Gln Lys Glu Gln 
            20                  25                  30          


Ile Ile Leu Asp Ile Gln Asn Glu Glu Val Gln Pro Thr Arg Arg Asp 
        35                  40                  45              


Lys Phe Arg Tyr Leu Leu Tyr Thr Cys Cys Ala Thr Ser Ser Arg Val 
    50                  55                  60                  


Leu Ala Trp Met Phe Leu Val Cys Ile Leu Leu Ile Ile Val Leu Val 
65                  70                  75                  80  


Ser Cys Phe Val Thr Ile Ser Arg Ile Gln Trp Asn Lys Asp Ile Gln 
                85                  90                  95      


Val Leu Gly Pro Val Ile Asp Trp Asn Val Thr Gln Arg Ala Val Tyr 
            100                 105                 110         


Gln Pro Leu Gln Thr Arg Arg Ile Ala Arg Ser Leu Arg Met Gln His 
        115                 120                 125             


Pro Val Pro Lys Tyr Val Glu Val Asn Met Thr Ser Ile Pro Gln Gly 
    130                 135                 140                 


Val Tyr Tyr Glu Pro His Pro Glu Pro Ile Val Val Lys Glu Arg Val 
145                 150                 155                 160 


Leu Gly Leu Ser Gln Ile Leu Met Ile Asn Ser Glu Asn Ile Ala Asn 
                165                 170                 175     


Asn Ala Asn Leu Thr Gln Glu Val Lys Lys Leu Leu Thr Glu Met Val 
            180                 185                 190         


Asn Glu Glu Met Gln Ser Leu Ser Asp Val Met Ile Asp Phe Glu Ile 
        195                 200                 205             


Pro Leu Gly Asp Pro Arg Asp Gln Glu Gln Tyr Ile His Arg Lys Cys 
    210                 215                 220                 


Tyr Gln Glu Phe Ala Asn Cys Tyr Leu Val Lys Tyr Lys Glu Pro Lys 
225                 230                 235                 240 


Pro Trp Pro Lys Glu Gly Leu Ile Ala Asp Gln Cys Pro Leu Pro Gly 
                245                 250                 255     


Tyr His Ala Gly Leu Thr Tyr Asn Arg Gln Ser Ile Trp Asp Tyr Tyr 
            260                 265                 270         


Ile Lys Val Glu Ser Ile Arg Pro Ala Asn Trp Thr Thr Lys Ser Lys 
        275                 280                 285             


Tyr Gly Gln Ala Arg Leu Gly Ser Phe Tyr Ile Pro Ser Ser Leu Arg 
    290                 295                 300                 


Gln Ile Asn Val Ser His Val Leu Phe Cys Ser Asp Gln Leu Tyr Ser 
305                 310                 315                 320 


Lys Trp Tyr Asn Ile Glu Asn Thr Ile Glu Gln Asn Glu Arg Phe Leu 
                325                 330                 335     


Leu Asn Lys Leu Asn Asn Leu Thr Ser Gly Thr Ser Val Leu Lys Lys 
            340                 345                 350         


Arg Ala Leu Pro Lys Asp Trp Ser Ser Gln Gly Lys Asn Ala Leu Phe 
        355                 360                 365             


Arg Glu Ile Asn Val Leu Asp Ile Cys Ser Lys Pro Glu Ser Val Ile 
    370                 375                 380                 


Leu Leu Asn Thr Ser Tyr Tyr Ser Phe Ser Leu Trp Glu Gly Asp Cys 
385                 390                 395                 400 


Asn Phe Thr Lys Asp Met Ile Ser Gln Leu Val Pro Glu Cys Asp Gly 
                405                 410                 415     


Phe Tyr Asn Asn Ser Lys Trp Met His Met His Pro Tyr Ala Cys Arg 
            420                 425                 430         


Phe Trp Arg Ser Lys Lys Asn Glu Lys Glu Glu Thr Lys Cys Arg Asp 
        435                 440                 445             


Gly Glu Thr Lys Arg Cys Leu Tyr Tyr Pro Leu Trp Asp Ser Pro Glu 
    450                 455                 460                 


Ser Thr Tyr Asp Phe Gly Tyr Leu Ala Tyr Gln Lys Asn Phe Pro Ser 
465                 470                 475                 480 


Pro Ile Cys Ile Glu Gln Gln Lys Ile Arg Asp Gln Asp Tyr Glu Val 
                485                 490                 495     


Tyr Ser Leu Tyr Gln Glu Arg Lys Ile Ala Ser Lys Ala Tyr Gly Ile 
            500                 505                 510         


Asp Thr Val Leu Phe Ser Leu Lys Asn Phe Leu Asn Tyr Thr Gly Thr 
        515                 520                 525             


Pro Val Asn Glu Met Pro Asn Ala Arg Ala Phe Val Gly Leu Ile Asp 
    530                 535                 540                 


Pro Lys Phe Pro Pro Ser Tyr Pro Asn Val Thr Arg Glu His Tyr Thr 
545                 550                 555                 560 


Ser Cys Asn Asn Arg Lys Arg Arg Ser Val Asp Asn Asn Tyr Ala Lys 
                565                 570                 575     


Leu Arg Ser Met Gly Tyr Ala Leu Thr Gly Ala Val Gln Thr Leu Ser 
            580                 585                 590         


Gln Ile Ser Asp Ile Asn Asp Glu Asn Leu Gln Gln Gly Ile Tyr Leu 
        595                 600                 605             


Leu Arg Asp His Val Ile Thr Leu Met Glu Ala Thr Leu His Asp Ile 
    610                 615                 620                 


Ser Val Met Glu Gly Met Phe Ala Val Gln His Leu His Thr His Leu 
625                 630                 635                 640 


Asn His Leu Lys Thr Met Leu Leu Glu Arg Arg Ile Asp Trp Thr Tyr 
                645                 650                 655     


Met Ser Ser Thr Trp Leu Gln Gln Gln Leu Gln Lys Ser Asp Asp Glu 
            660                 665                 670         


Met Lys Val Ile Lys Arg Ile Ala Arg Ser Leu Val Tyr Tyr Val Lys 
        675                 680                 685             


Gln Thr His Ser Ser Pro Thr Ala Thr Ala Trp Glu Ile Gly Leu Tyr 
    690                 695                 700                 


Tyr Glu Leu Val Ile Pro Lys His Ile Tyr Leu Asn Asn Trp Asn Val 
705                 710                 715                 720 


Val Asn Ile Gly His Leu Val Lys Ser Ala Gly Gln Leu Thr His Val 
                725                 730                 735     


Thr Ile Ala His Pro Tyr Glu Ile Ile Asn Lys Glu Cys Val Glu Thr 
            740                 745                 750         


Ile Tyr Leu His Leu Glu Asp Cys Thr Arg Gln Asp Tyr Val Ile Cys 
        755                 760                 765             


Asp Val Val Lys Ile Val Gln Pro Cys Gly Asn Ser Ser Asp Thr Ser 
    770                 775                 780                 


Asp Cys Pro Val Trp Ala Glu Ala Val Lys Glu Pro Phe Val Gln Val 
785                 790                 795                 800 


Asn Pro Leu Lys Asn Gly Ser Tyr Leu Val Leu Ala Ser Ser Thr Asp 
                805                 810                 815     


Cys Gln Ile Pro Pro Tyr Val Pro Ser Ile Val Thr Val Asn Glu Thr 
            820                 825                 830         


Thr Ser Cys Phe Gly Leu Asp Phe Lys Arg Pro Leu Val Ala Glu Glu 
        835                 840                 845             


Arg Leu Ser Phe Glu Pro Arg Leu Pro Asn Leu Gln Leu Arg Leu Pro 
    850                 855                 860                 


His Leu Val Gly Ile Ile Ala Lys Ile Lys Gly Ile Lys Ile Glu Val 
865                 870                 875                 880 


Thr Ser Ser Gly Glu Ser Ile Lys Glu Gln Ile Glu Arg Ala Lys Ala 
                885                 890                 895     


Glu Leu Leu Arg Leu Asp Ile His Glu Gly Asp Thr Pro Ala Trp Ile 
            900                 905                 910         


Gln Gln Leu Ala Ala Ala Thr Lys Asp Val Trp Pro Ala Ala Ala Ser 
        915                 920                 925             


Ala Leu Gln Gly Ile Gly Asn Phe Leu Ser Gly Thr Ala Gln Gly Ile 
    930                 935                 940                 


Phe Gly Thr Ala Phe Ser Leu Leu Gly Tyr Leu Lys Pro Ile Leu Ile 
945                 950                 955                 960 


Gly Val Gly Val Ile Leu Leu Val Ile Leu Ile Phe Lys Ile Val Ser 
                965                 970                 975     


Trp Ile Pro Thr Lys Lys Lys Asn Gln 
            980                 985 


<210>  12
<211>  913
<212>  PRT
<213>  Psuedorabies virus

<400>  12

Met Pro Ala Gly Gly Gly Leu Trp Arg Gly Pro Arg Gly His Arg Pro 
1               5                   10                  15      


Gly His His Gly Gly Ala Gly Leu Gly Arg Leu Trp Pro Ala Pro His 
            20                  25                  30          


His Ala Ala Ala Ala Arg Gly Ala Val Ala Leu Ala Leu Leu Leu Leu 
        35                  40                  45              


Ala Leu Ala Ala Ala Pro Pro Cys Gly Ala Ala Ala Val Thr Arg Ala 
    50                  55                  60                  


Ala Ser Ala Ser Pro Thr Pro Gly Thr Gly Ala Thr Pro Asn Asp Val 
65                  70                  75                  80  


Ser Ala Glu Ala Ser Leu Glu Glu Ile Glu Ala Phe Ser Pro Gly Pro 
                85                  90                  95      


Ser Glu Ala Pro Asp Gly Glu Tyr Gly Asp Leu Asp Ala Arg Thr Ala 
            100                 105                 110         


Val Arg Ala Ala Ala Thr Glu Arg Asp Arg Phe Tyr Val Cys Pro Pro 
        115                 120                 125             


Pro Ser Gly Ser Thr Val Val Arg Leu Glu Pro Glu Gln Ala Cys Pro 
    130                 135                 140                 


Glu Tyr Ser Gln Gly Arg Asn Phe Thr Glu Gly Ile Ala Val Leu Phe 
145                 150                 155                 160 


Lys Glu Asn Ile Ala Pro His Lys Phe Lys Ala His Ile Tyr Tyr Lys 
                165                 170                 175     


Asn Val Ile Val Thr Thr Val Trp Ser Gly Ser Thr Tyr Ala Ala Ile 
            180                 185                 190         


Thr Asn Arg Phe Thr Asp Arg Val Pro Val Pro Val Gln Glu Ile Thr 
        195                 200                 205             


Asp Val Ile Asp Arg Arg Gly Lys Cys Val Ser Lys Ala Glu Tyr Val 
    210                 215                 220                 


Arg Asn Asn His Lys Val Thr Ala Phe Asp Arg Asp Glu Asn Pro Val 
225                 230                 235                 240 


Glu Val Asp Leu Arg Pro Ser Arg Leu Asn Ala Leu Gly Thr Arg Gly 
                245                 250                 255     


Trp His Thr Thr Asn Asp Thr Tyr Thr Lys Ile Gly Ala Ala Gly Phe 
            260                 265                 270         


Tyr His Thr Gly Thr Ser Val Asn Cys Ile Val Glu Glu Val Glu Ala 
        275                 280                 285             


Arg Ser Val Tyr Pro Tyr Asp Ser Phe Ala Leu Ser Thr Gly Asp Ile 
    290                 295                 300                 


Val Tyr Met Ser Pro Phe Tyr Gly Leu Arg Glu Gly Ala His Gly Glu 
305                 310                 315                 320 


His Ile Gly Tyr Ala Pro Gly Arg Phe Gln Gln Val Glu His Tyr Tyr 
                325                 330                 335     


Pro Ile Asp Leu Asp Ser Arg Leu Arg Ala Ser Glu Ser Val Thr Arg 
            340                 345                 350         


Asn Phe Leu Arg Thr Pro His Phe Thr Val Ala Trp Asp Trp Ala Pro 
        355                 360                 365             


Lys Thr Arg Arg Val Cys Ser Leu Ala Lys Trp Arg Glu Ala Glu Glu 
    370                 375                 380                 


Met Thr Arg Asp Glu Thr Arg Asp Gly Ser Phe Arg Phe Thr Ser Arg 
385                 390                 395                 400 


Ala Leu Gly Ala Ser Phe Val Ser Asp Val Thr Gln Leu Asp Leu Gln 
                405                 410                 415     


Arg Val His Leu Gly Asp Cys Val Leu Arg Glu Ala Ser Glu Ala Ile 
            420                 425                 430         


Asp Ala Ile Tyr Arg Arg Arg Tyr Asn Ser Thr His Val Leu Ala Gly 
        435                 440                 445             


Asp Arg Pro Glu Val Tyr Leu Ala Arg Gly Gly Phe Val Val Ala Phe 
    450                 455                 460                 


Arg Pro Leu Ile Ser Asn Glu Leu Ala Gln Leu Tyr Ala Arg Glu Leu 
465                 470                 475                 480 


Glu Arg Leu Gly Leu Ala Gly Val Val Gly Pro Ala Ala Pro Ala Ala 
                485                 490                 495     


Ala Arg Arg Ala Arg Arg Ser Pro Gly Pro Ala Gly Thr Pro Glu Pro 
            500                 505                 510         


Pro Ala Val Asn Gly Thr Gly His Leu Arg Ile Thr Thr Gly Ser Ala 
        515                 520                 525             


Glu Phe Ala Arg Leu Gln Phe Thr Tyr Asp His Ile Gln Ala His Val 
    530                 535                 540                 


Asn Asp Met Leu Gly Arg Ile Ala Ala Ala Trp Cys Glu Leu Gln Asn 
545                 550                 555                 560 


Lys Asp Arg Thr Leu Trp Ser Glu Met Ser Arg Leu Asn Pro Ser Ala 
                565                 570                 575     


Val Ala Thr Ala Ala Leu Gly Gln Arg Val Ser Ala Arg Met Leu Gly 
            580                 585                 590         


Asp Val Met Ala Ile Ser Arg Cys Val Glu Val Arg Gly Gly Val Tyr 
        595                 600                 605             


Val Gln Asn Ser Met Arg Val Pro Gly Glu Arg Gly Thr Cys Tyr Ser 
    610                 615                 620                 


Arg Pro Leu Val Thr Phe Glu His Asn Gly Thr Gly Val Ile Glu Gly 
625                 630                 635                 640 


Gln Leu Gly Asp Asp Asn Glu Leu Leu Ile Ser Arg Asp Leu Ile Glu 
                645                 650                 655     


Pro Cys Thr Gly Asn His Arg Arg Tyr Phe Lys Leu Gly Ser Gly Tyr 
            660                 665                 670         


Val Tyr Tyr Glu Asp Tyr Asn Tyr Val Arg Met Val Glu Val Pro Glu 
        675                 680                 685             


Thr Ile Ser Thr Arg Val Thr Leu Asn Leu Thr Leu Leu Glu Asp Arg 
    690                 695                 700                 


Glu Phe Leu Pro Leu Glu Val Tyr Thr Arg Glu Glu Leu Ala Asp Thr 
705                 710                 715                 720 


Gly Leu Leu Asp Tyr Ser Glu Ile Gln Arg Arg Asn Gln Leu His Ala 
                725                 730                 735     


Leu Lys Phe Tyr Asp Ile Asp Arg Val Val Lys Val Asp His Asn Val 
            740                 745                 750         


Val Leu Leu Arg Gly Ile Ala Asn Phe Phe Gln Gly Leu Gly Asp Val 
        755                 760                 765             


Gly Ala Ala Val Gly Lys Val Val Leu Gly Ala Thr Gly Ala Val Ile 
    770                 775                 780                 


Ser Ala Val Gly Gly Met Val Ser Phe Leu Ser Asn Pro Phe Gly Ala 
785                 790                 795                 800 


Leu Ala Ile Gly Leu Leu Val Leu Ala Gly Leu Val Ala Ala Phe Leu 
                805                 810                 815     


Ala Tyr Arg His Ile Ser Arg Leu Arg Arg Asn Pro Met Lys Ala Leu 
            820                 825                 830         


Tyr Pro Val Thr Thr Lys Thr Leu Lys Glu Asp Gly Val Asp Glu Gly 
        835                 840                 845             


Asp Val Asp Glu Ala Lys Leu Asp Gln Ala Arg Asp Met Ile Arg Tyr 
    850                 855                 860                 


Met Ser Ile Val Ser Ala Leu Glu Gln Gln Glu His Lys Ala Arg Lys 
865                 870                 875                 880 


Lys Asn Ser Gly Pro Ala Leu Leu Ala Ser Arg Val Gly Ala Met Ala 
                885                 890                 895     


Thr Arg Arg Arg His Tyr Gln Arg Leu Glu Ser Glu Asp Pro Asp Ala 
            900                 905                 910         


Leu 
    


<210>  13
<211>  400
<212>  PRT
<213>  Psuedorabies virus

<400>  13

Met Leu Leu Ala Ala Leu Leu Ala Ala Leu Val Ala Arg Thr Thr Leu 
1               5                   10                  15      


Gly Ala Asp Val Asp Ala Val Pro Ala Pro Thr Phe Pro Pro Pro Ala 
            20                  25                  30          


Tyr Pro Tyr Thr Glu Ser Trp Gln Leu Thr Leu Thr Thr Val Pro Ser 
        35                  40                  45              


Pro Phe Val Gly Pro Ala Asp Val Tyr His Thr Arg Pro Leu Glu Asp 
    50                  55                  60                  


Pro Cys Gly Val Val Ala Leu Ile Ser Asp Pro Gln Val Asp Arg Leu 
65                  70                  75                  80  


Leu Asn Glu Ala Val Ala His Arg Arg Pro Thr Tyr Arg Ala His Val 
                85                  90                  95      


Ala Trp Tyr Arg Ile Ala Asp Gly Cys Ala His Leu Leu Tyr Phe Ile 
            100                 105                 110         


Glu Tyr Ala Asp Cys Asp Pro Arg Gln Ile Phe Gly Arg Cys Arg Arg 
        115                 120                 125             


Arg Thr Thr Pro Met Trp Trp Thr Pro Ser Ala Asp Tyr Met Phe Pro 
    130                 135                 140                 


Thr Glu Asp Glu Leu Gly Leu Leu Met Val Ala Pro Gly Arg Phe Asn 
145                 150                 155                 160 


Glu Gly Gln Tyr Arg Arg Leu Val Ser Val Asp Gly Val Asn Ile Leu 
                165                 170                 175     


Thr Asp Phe Met Val Ala Leu Pro Glu Gly Gln Glu Cys Pro Phe Ala 
            180                 185                 190         


Arg Val Asp Gln His Arg Thr Tyr Lys Phe Gly Ala Cys Trp Asn Asp 
        195                 200                 205             


Glu Ser Phe Arg Arg Gly Val Asp Val Met Arg Phe Leu Thr Pro Phe 
    210                 215                 220                 


Tyr Gln Gln Pro Pro His Arg Glu Val Val Asn Tyr Trp Tyr Arg Lys 
225                 230                 235                 240 


Asn Gly Arg Thr Leu Pro Arg Ala Tyr Ala Ala Ala Thr Pro Tyr Ala 
                245                 250                 255     


Ile Asp Pro Ala Arg Pro Ser Ala Gly Ser Pro Arg Pro Arg Pro Arg 
            260                 265                 270         


Pro Arg Pro Arg Pro Lys Pro Glu Pro Ala Pro Val Thr Pro Ala Pro 
        275                 280                 285             


Pro Gly Arg Leu Pro Glu Pro Ala Thr Arg Asp His Ala Ala Gly Gly 
    290                 295                 300                 


His Pro Thr Pro Arg Pro Pro Arg Pro Glu Thr Pro His Arg Pro Phe 
305                 310                 315                 320 


Ala Pro Pro Ala Val Val Pro Ser Gly Trp Pro Gln Pro Ala Glu Pro 
                325                 330                 335     


Phe Gln Pro Arg Thr Pro Ala Ala Pro Gly Val Ser Arg His Arg Ser 
            340                 345                 350         


Val Ile Val Gly Thr Gly Thr Ala Met Gly Ala Leu Leu Val Gly Val 
        355                 360                 365             


Cys Val Tyr Ile Phe Phe Arg Leu Arg Gly Ala Lys Gly Tyr Arg Leu 
    370                 375                 380                 


Leu Gly Gly Pro Ala Asp Thr Asp Glu Leu Lys Ala Gln Pro Gly Pro 
385                 390                 395                 400 


<210>  14
<211>  686
<212>  PRT
<213>  Psuedorabies virus

<400>  14

Met Pro Ala Ser Ser Val Arg Leu Pro Leu Arg Leu Leu Thr Leu Ala 
1               5                   10                  15      


Gly Leu Leu Ala Leu Ala Gly Ala Ala Ala Leu Ala Arg Gly Ala Pro 
            20                  25                  30          


Gln Gly Gly Pro Pro Ser Pro Gln Gly Gly Pro Ala Pro Thr Ala Ala 
        35                  40                  45              


Pro Ala Arg Gly Pro Thr Leu Phe Val Leu Val Gly Asp Gly Ser Ala 
    50                  55                  60                  


Trp Phe Val Phe Gln Leu Gly Gly Leu Gly Ala Leu Asn Asp Thr Arg 
65                  70                  75                  80  


Ile Arg Gly His Leu Leu Gly Arg Tyr Leu Val Ser Tyr Gln Val Val 
                85                  90                  95      


Pro Pro Pro Val Ser Ala Trp Tyr Phe Val Gln Arg Pro Arg Glu Arg 
            100                 105                 110         


Pro Arg Leu Ser Gly Pro Pro Ser Gly Ala Glu Leu Val Ala Phe Asp 
        115                 120                 125             


Ala Pro Gly Val Arg Arg Thr Tyr Thr Thr Ala Ala Val Trp Pro Ala 
    130                 135                 140                 


Glu Val Ala Val Leu Ala Asp Ala Glu Ala Arg Cys Pro Ala Ala Val 
145                 150                 155                 160 


Phe Asn Val Thr Leu Gly Glu Ala Phe Leu Gly Leu Arg Val Ala Leu 
                165                 170                 175     


Arg Ser Phe Leu Pro Leu Glu Val Ile Ile Ser Ala Glu Arg Met Arg 
            180                 185                 190         


Met Ile Ala Pro Pro Ala Leu Gly Ser Asp Leu Glu Pro Pro Gly Pro 
        195                 200                 205             


Pro Ala Gly Arg Phe His Val Tyr Thr Leu Gly Phe Leu Ser Asp Gly 
    210                 215                 220                 


Ala Met His Gln Thr Met Arg Asp Val Ala Ala Tyr Val His Glu Ser 
225                 230                 235                 240 


Asp Asp Tyr Leu Ala Gln Leu Ser Ala Ala His Ala Ala Ala Leu Ala 
                245                 250                 255     


Ala Val Val Gln Pro Gly Pro Tyr Tyr Phe Tyr Arg Ala Ala Val Arg 
            260                 265                 270         


Leu Gly Val Ala Ala Phe Val Phe Ser Glu Ala Ala Arg Arg Asp Arg 
        275                 280                 285             


Arg Ala Ser Ala Pro Ala Leu Leu Arg Val Glu Ser Asp Ala Arg Leu 
    290                 295                 300                 


Leu Ser Arg Leu Leu Met Arg Ala Ala Gly Cys Pro Ala Gly Phe Ala 
305                 310                 315                 320 


Gly Leu Phe Asp Gly Arg Ala Glu Arg Val Pro Val Ala Pro Ala Asp 
                325                 330                 335     


Gln Leu Arg Ala Ala Trp Thr Phe Gly Glu Asp Pro Ala Pro Arg Leu 
            340                 345                 350         


Asp Leu Ala Arg Ala Thr Val Ala Glu Ala Tyr Arg Arg Ser Val Arg 
        355                 360                 365             


Gly Lys Pro Phe Asp Gln Gln Ala Leu Phe Phe Ala Val Ala Leu Leu 
    370                 375                 380                 


Leu Arg Ala Gly Gly Pro Gly Asp Ala Arg Glu Thr Leu Leu Arg Thr 
385                 390                 395                 400 


Thr Ala Met Cys Thr Ala Glu Arg Ala Ala Ala Ala Ala Glu Leu Thr 
                405                 410                 415     


Arg Ala Ala Leu Ser Pro Thr Ala Ala Trp Asn Glu Pro Phe Ser Leu 
            420                 425                 430         


Leu Asp Val Leu Ser Pro Cys Ala Val Ser Leu Arg Arg Asp Leu Gly 
        435                 440                 445             


Gly Asp Ala Thr Leu Ala Asn Leu Gly Ala Ala Ala Arg Leu Ala Leu 
    450                 455                 460                 


Ala Pro Ala Gly Ala Pro Gly Ala Ala Ala Ala Thr Asp Glu Gly Ala 
465                 470                 475                 480 


Glu Glu Glu Glu Glu Asp Pro Val Ala Arg Ala Ala Pro Glu Ile Pro 
                485                 490                 495     


Ala Glu Ala Leu Leu Ala Leu Pro Leu Arg Gly Gly Ala Ser Phe Val 
            500                 505                 510         


Phe Thr Arg Arg Arg Pro Asp Cys Gly Pro Ala Tyr Thr Leu Gly Gly 
        515                 520                 525             


Val Asp Ile Ala Asn Pro Leu Val Leu Ala Ile Val Ser Asn Asp Ser 
    530                 535                 540                 


Ala Ala Cys Asp Tyr Thr Asp Arg Met Pro Glu Ser Gln His Leu Pro 
545                 550                 555                 560 


Ala Thr Asp Asn Pro Ser Val Cys Val Tyr Cys Asp Cys Val Phe Val 
                565                 570                 575     


Arg Tyr Ser Ser Ala Gly Thr Ile Leu Glu Thr Val Leu Ile Glu Ser 
            580                 585                 590         


Lys Asp Met Glu Glu Gln Leu Met Ala Gly Ala Asn Ser Thr Ile Pro 
        595                 600                 605             


Ser Phe Asn Pro Thr Leu His Gly Gly Asp Val Lys Ala Leu Met Leu 
    610                 615                 620                 


Phe Pro Asn Gly Thr Val Val Asp Leu Leu Ser Phe Thr Ser Thr Arg 
625                 630                 635                 640 


Leu Ala Pro Val Ser Pro Ala Tyr Val Val Ala Ser Val Val Gly Ala 
                645                 650                 655     


Ala Ile Thr Val Gly Ile Leu Tyr Ala Leu Phe Lys Met Leu Cys Ser 
            660                 665                 670         


Phe Ser Ser Glu Gly Tyr Ser Arg Leu Ile Asn Ala Arg Ser 
        675                 680                 685     


<210>  15
<211>  156
<212>  PRT
<213>  Psuedorabies virus

<400>  15

Met Ser Pro Leu Val Ala Val Leu Val Phe Phe Ser Ala Ala Leu Gly 
1               5                   10                  15      


Ile Pro Gly Pro Gly Val Ala Gly Asn Pro Arg Gly Leu Asp Ala Ile 
            20                  25                  30          


Phe Glu Ala Pro Val Thr Pro Ala Pro Pro Thr Arg His Pro Arg Arg 
        35                  40                  45              


Glu Glu Leu Glu Trp Asp Asp Glu Asp His Pro Leu Leu Asp Leu Glu 
    50                  55                  60                  


Pro Pro Val Gly Ser Arg Cys His Pro Tyr Ile Ala Tyr Ser Leu Pro 
65                  70                  75                  80  


Pro Asp Met Asn Ala Val Thr Ser Val Val Val Lys Pro Tyr Cys Ser 
                85                  90                  95      


Pro Pro Glu Val Ile Leu Trp Ala Ser Gly Thr Ala Tyr Leu Val Asn 
            100                 105                 110         


Pro Phe Val Ala Ile Gln Ala Leu Ala Val Gly Glu Pro Leu Asn Glu 
        115                 120                 125             


Ala Ala Leu Lys Glu Leu Gly Glu Val Ala Val His Lys Asp Ser Leu 
    130                 135                 140                 


Pro Pro Leu Arg Tyr Asn Gly Gly Pro Pro Ala Glu 
145                 150                 155     


<210>  16
<211>  904
<212>  PRT
<213>  Herpes simplex virus 1 (HHV1)

<400>  16

Met Arg Gln Gly Ala Pro Ala Arg Gly Arg Arg Trp Phe Val Val Trp 
1               5                   10                  15      


Ala Leu Leu Gly Leu Thr Leu Gly Val Leu Val Ala Ser Ala Ala Pro 
            20                  25                  30          


Ser Ser Pro Gly Thr Pro Gly Val Ala Ala Ala Thr Gln Ala Ala Asn 
        35                  40                  45              


Gly Gly Pro Ala Thr Pro Ala Pro Pro Ala Pro Gly Ala Pro Pro Thr 
    50                  55                  60                  


Gly Asp Pro Lys Pro Lys Lys Asn Lys Lys Pro Lys Pro Pro Lys Pro 
65                  70                  75                  80  


Pro Arg Pro Ala Gly Asp Asn Ala Thr Val Ala Ala Gly His Ala Thr 
                85                  90                  95      


Leu Arg Glu His Leu Arg Asp Ile Lys Ala Glu Asn Thr Asp Ala Asn 
            100                 105                 110         


Phe Tyr Val Cys Pro Pro Pro Thr Gly Ala Thr Val Val Gln Phe Glu 
        115                 120                 125             


Gln Pro Arg Arg Cys Pro Thr Arg Pro Glu Gly Gln Asn Tyr Thr Glu 
    130                 135                 140                 


Gly Ile Ala Val Val Phe Lys Glu Asn Ile Ala Pro Tyr Lys Phe Lys 
145                 150                 155                 160 


Ala Thr Met Tyr Tyr Lys Asp Val Thr Val Ser Gln Val Trp Phe Gly 
                165                 170                 175     


His Arg Tyr Ser Gln Phe Met Gly Ile Phe Glu Asp Arg Ala Pro Val 
            180                 185                 190         


Pro Phe Glu Glu Val Ile Asp Lys Ile Asn Ala Lys Gly Val Cys Arg 
        195                 200                 205             


Ser Thr Ala Lys Tyr Val Arg Asn Asn Leu Glu Thr Thr Ala Phe His 
    210                 215                 220                 


Arg Asp Asp His Glu Thr Asp Met Glu Leu Lys Pro Ala Asn Ala Ala 
225                 230                 235                 240 


Thr Arg Thr Ser Arg Gly Trp His Thr Thr Asp Leu Lys Tyr Asn Pro 
                245                 250                 255     


Ser Arg Val Glu Ala Phe His Arg Tyr Gly Thr Thr Val Asn Cys Ile 
            260                 265                 270         


Val Glu Glu Val Asp Ala Arg Ser Val Tyr Pro Tyr Asp Glu Phe Val 
        275                 280                 285             


Leu Ala Thr Gly Asp Phe Val Tyr Met Ser Pro Phe Tyr Gly Tyr Arg 
    290                 295                 300                 


Glu Gly Ser His Thr Glu His Thr Ser Tyr Ala Ala Asp Arg Phe Lys 
305                 310                 315                 320 


Gln Val Asp Gly Phe Tyr Ala Arg Asp Leu Thr Thr Lys Ala Arg Ala 
                325                 330                 335     


Thr Ala Pro Thr Thr Arg Asn Leu Leu Thr Thr Pro Lys Phe Thr Val 
            340                 345                 350         


Ala Trp Asp Trp Val Pro Lys Arg Pro Ser Val Cys Thr Met Thr Lys 
        355                 360                 365             


Trp Gln Glu Val Asp Glu Met Leu Arg Ser Glu Tyr Gly Gly Ser Phe 
    370                 375                 380                 


Arg Phe Ser Ser Asp Ala Ile Ser Thr Thr Phe Thr Thr Asn Leu Thr 
385                 390                 395                 400 


Glu Tyr Pro Leu Ser Arg Val Asp Leu Gly Asp Cys Ile Gly Lys Asp 
                405                 410                 415     


Ala Arg Asp Ala Met Asp Arg Ile Phe Ala Arg Arg Tyr Asn Ala Thr 
            420                 425                 430         


His Ile Lys Val Gly Gln Pro Gln Tyr Tyr Leu Ala Asn Gly Gly Phe 
        435                 440                 445             


Leu Ile Ala Tyr Gln Pro Leu Leu Ser Asn Thr Leu Ala Glu Leu Tyr 
    450                 455                 460                 


Val Arg Glu His Leu Arg Glu Gln Ser Arg Lys Pro Pro Asn Pro Thr 
465                 470                 475                 480 


Pro Pro Pro Pro Gly Ala Ser Ala Asn Ala Ser Val Glu Arg Ile Lys 
                485                 490                 495     


Thr Thr Ser Ser Ile Glu Phe Ala Arg Leu Gln Phe Thr Tyr Asn His 
            500                 505                 510         


Ile Gln Arg His Val Asn Asp Met Leu Gly Arg Val Ala Ile Ala Trp 
        515                 520                 525             


Cys Glu Leu Gln Asn His Glu Leu Thr Leu Trp Asn Glu Ala Arg Lys 
    530                 535                 540                 


Leu Asn Pro Asn Ala Ile Ala Ser Ala Thr Val Gly Arg Arg Val Ser 
545                 550                 555                 560 


Ala Arg Met Leu Gly Asp Val Met Ala Val Ser Thr Cys Val Pro Val 
                565                 570                 575     


Ala Ala Asp Asn Val Ile Val Gln Asn Ser Met Arg Ile Ser Ser Arg 
            580                 585                 590         


Pro Gly Ala Cys Tyr Ser Arg Pro Leu Val Ser Phe Arg Tyr Glu Asp 
        595                 600                 605             


Gln Gly Pro Leu Val Glu Gly Gln Leu Gly Glu Asn Asn Glu Leu Arg 
    610                 615                 620                 


Leu Thr Arg Asp Ala Ile Glu Pro Cys Thr Val Gly His Arg Arg Tyr 
625                 630                 635                 640 


Phe Thr Phe Gly Gly Gly Tyr Val Tyr Phe Glu Glu Tyr Ala Tyr Ser 
                645                 650                 655     


His Gln Leu Ser Arg Ala Asp Ile Thr Thr Val Ser Thr Phe Ile Asp 
            660                 665                 670         


Leu Asn Ile Thr Met Leu Glu Asp His Glu Phe Val Pro Leu Glu Val 
        675                 680                 685             


Tyr Thr Arg His Glu Ile Lys Asp Ser Gly Leu Leu Asp Tyr Thr Glu 
    690                 695                 700                 


Val Gln Arg Arg Asn Gln Leu His Asp Leu Arg Phe Ala Asp Ile Asp 
705                 710                 715                 720 


Thr Val Ile His Ala Asp Ala Asn Ala Ala Met Phe Ala Gly Leu Gly 
                725                 730                 735     


Ala Phe Phe Glu Gly Met Gly Asp Leu Gly Arg Ala Val Gly Lys Val 
            740                 745                 750         


Val Met Gly Ile Val Gly Gly Val Val Ser Ala Val Ser Gly Val Ser 
        755                 760                 765             


Ser Phe Met Ser Asn Pro Phe Gly Ala Leu Ala Val Gly Leu Leu Val 
    770                 775                 780                 


Leu Ala Gly Leu Ala Ala Ala Phe Phe Ala Phe Arg Tyr Val Met Arg 
785                 790                 795                 800 


Leu Gln Ser Asn Pro Met Lys Ala Leu Tyr Pro Leu Thr Thr Lys Glu 
                805                 810                 815     


Leu Lys Asn Pro Thr Asn Pro Asp Ala Ser Gly Glu Gly Glu Glu Gly 
            820                 825                 830         


Gly Asp Phe Asp Glu Ala Lys Leu Ala Glu Ala Arg Glu Met Ile Arg 
        835                 840                 845             


Tyr Met Ala Leu Val Ser Ala Met Glu Arg Thr Glu His Lys Ala Lys 
    850                 855                 860                 


Lys Lys Gly Thr Ser Ala Leu Leu Ser Ala Lys Val Thr Asp Met Val 
865                 870                 875                 880 


Met Arg Lys Arg Arg Asn Thr Asn Tyr Thr Gln Val Pro Asn Lys Asp 
                885                 890                 895     


Gly Asp Ala Asp Glu Asp Asp Leu 
            900                 


<210>  17
<211>  394
<212>  PRT
<213>  Herpes simplex virus 1 (HHV1)

<400>  17

Met Gly Gly Ala Ala Ala Arg Leu Gly Ala Val Ile Leu Phe Val Val 
1               5                   10                  15      


Ile Val Gly Leu His Gly Val Arg Ser Lys Tyr Ala Leu Val Asp Ala 
            20                  25                  30          


Ser Leu Lys Met Ala Asp Pro Asn Arg Phe Arg Gly Lys Asp Leu Pro 
        35                  40                  45              


Val Leu Asp Gln Leu Thr Asp Pro Pro Gly Val Arg Arg Val Tyr His 
    50                  55                  60                  


Ile Gln Ala Gly Leu Pro Asp Pro Phe Gln Pro Pro Ser Leu Pro Ile 
65                  70                  75                  80  


Thr Val Tyr Tyr Ala Val Leu Glu Arg Ala Cys Arg Ser Val Leu Leu 
                85                  90                  95      


Asn Ala Pro Ser Glu Ala Pro Gln Ile Val Arg Gly Ala Ser Glu Asp 
            100                 105                 110         


Val Arg Lys Gln Pro Tyr Asn Leu Thr Ile Ala Trp Phe Arg Met Gly 
        115                 120                 125             


Gly Asn Cys Ala Ile Pro Ile Thr Val Met Glu Tyr Thr Glu Cys Ser 
    130                 135                 140                 


Tyr Asn Lys Ser Leu Gly Ala Cys Pro Ile Arg Thr Gln Pro Arg Trp 
145                 150                 155                 160 


Asn Tyr Tyr Asp Ser Phe Ser Ala Val Ser Glu Asp Asn Leu Gly Phe 
                165                 170                 175     


Leu Met His Ala Pro Ala Phe Glu Thr Ala Gly Thr Tyr Leu Arg Leu 
            180                 185                 190         


Val Lys Ile Asn Asp Trp Thr Glu Ile Thr Gln Phe Ile Leu Glu His 
        195                 200                 205             


Arg Ala Lys Gly Ser Cys Lys Tyr Ala Leu Pro Leu Arg Ile Pro Pro 
    210                 215                 220                 


Ser Ala Cys Leu Ser Pro Gln Ala Tyr Gln Gln Gly Val Thr Val Asp 
225                 230                 235                 240 


Ser Ile Gly Met Leu Pro Arg Phe Ile Pro Glu Asn Gln Arg Thr Val 
                245                 250                 255     


Ala Val Tyr Ser Leu Lys Ile Ala Gly Trp His Gly Pro Lys Ala Pro 
            260                 265                 270         


Tyr Thr Ser Thr Leu Leu Pro Pro Glu Leu Ser Glu Thr Pro Asn Ala 
        275                 280                 285             


Thr Gln Pro Glu Leu Ala Pro Glu Asp Pro Glu Asp Ser Ala Leu Leu 
    290                 295                 300                 


Glu Asp Pro Val Gly Thr Val Ala Pro Gln Ile Pro Pro Asn Trp His 
305                 310                 315                 320 


Ile Pro Ser Ile Gln Asp Ala Ala Thr Pro Tyr His Pro Pro Ala Thr 
                325                 330                 335     


Pro Asn Asn Met Gly Leu Ile Ala Gly Ala Val Gly Gly Ser Leu Leu 
            340                 345                 350         


Ala Ala Leu Val Ile Cys Gly Ile Val Tyr Trp Met Arg Arg His Thr 
        355                 360                 365             


Gln Lys Ala Pro Lys Arg Ile Arg Leu Pro His Ile Arg Glu Asp Asp 
    370                 375                 380                 


Gln Pro Ser Ser His Gln Pro Leu Phe Tyr 
385                 390                 


<210>  18
<211>  838
<212>  PRT
<213>  Herpes simplex virus 1 (HHV1)

<400>  18

Met Gly Asn Gly Leu Trp Phe Val Gly Val Ile Ile Leu Gly Val Ala 
1               5                   10                  15      


Trp Gly Gln Val His Asp Trp Thr Glu Gln Thr Asp Pro Trp Phe Leu 
            20                  25                  30          


Asp Gly Leu Gly Met Asp Arg Met Tyr Trp Arg Asp Thr Asn Thr Gly 
        35                  40                  45              


Arg Leu Trp Leu Pro Asn Thr Pro Asp Pro Gln Lys Pro Pro Arg Gly 
    50                  55                  60                  


Phe Leu Ala Pro Pro Asp Glu Leu Asn Leu Thr Thr Ala Ser Leu Pro 
65                  70                  75                  80  


Leu Leu Arg Trp Tyr Glu Glu Arg Phe Cys Phe Val Leu Val Thr Thr 
                85                  90                  95      


Ala Glu Phe Pro Arg Asp Pro Gly Gln Leu Leu Tyr Ile Pro Lys Thr 
            100                 105                 110         


Tyr Leu Leu Gly Arg Pro Pro Asn Ala Ser Leu Pro Ala Pro Thr Thr 
        115                 120                 125             


Val Glu Pro Thr Ala Gln Pro Pro Pro Ser Val Ala Pro Leu Lys Gly 
    130                 135                 140                 


Leu Leu His Asn Pro Val Ala Ser Val Leu Leu Arg Ser Arg Ala Trp 
145                 150                 155                 160 


Val Thr Phe Ser Ala Val Pro Asp Pro Glu Ala Leu Thr Phe Pro Arg 
                165                 170                 175     


Gly Asp Asn Val Ala Thr Ala Ser His Pro Ser Gly Pro Arg Asp Thr 
            180                 185                 190         


Pro Pro Pro Arg Pro Pro Val Gly Ala Arg Arg His Pro Thr Thr Glu 
        195                 200                 205             


Leu Asp Ile Thr His Leu His Asn Ala Ser Thr Thr Trp Leu Ala Thr 
    210                 215                 220                 


Arg Gly Leu Leu Arg Ser Pro Gly Arg Tyr Val Tyr Phe Ser Pro Ser 
225                 230                 235                 240 


Ala Ser Thr Trp Pro Val Gly Ile Trp Thr Thr Gly Glu Leu Val Leu 
                245                 250                 255     


Gly Cys Asp Ala Ala Leu Val Arg Ala Arg Tyr Gly Arg Glu Phe Met 
            260                 265                 270         


Gly Leu Val Ile Ser Met His Asp Ser Pro Pro Val Glu Val Met Val 
        275                 280                 285             


Val Pro Ala Gly Gln Thr Leu Asp Arg Val Gly Asp Pro Ala Asp Glu 
    290                 295                 300                 


Asn Pro Pro Gly Ala Leu Pro Gly Pro Pro Gly Gly Pro Arg Tyr Arg 
305                 310                 315                 320 


Val Phe Val Leu Gly Ser Leu Thr Arg Ala Asp Asn Gly Ser Ala Leu 
                325                 330                 335     


Asp Ala Leu Arg Arg Val Gly Gly Tyr Pro Glu Glu Gly Thr Asn Tyr 
            340                 345                 350         


Ala Gln Phe Leu Ser Arg Ala Tyr Ala Glu Phe Phe Ser Gly Asp Ala 
        355                 360                 365             


Gly Ala Glu Gln Gly Pro Arg Pro Pro Leu Phe Trp Arg Leu Thr Gly 
    370                 375                 380                 


Leu Leu Ala Thr Ser Gly Phe Ala Phe Val Asn Ala Ala His Ala Asn 
385                 390                 395                 400 


Gly Ala Val Cys Leu Ser Asp Leu Leu Gly Phe Leu Ala His Ser Arg 
                405                 410                 415     


Ala Leu Ala Gly Leu Ala Ala Arg Gly Ala Ala Gly Cys Ala Ala Asp 
            420                 425                 430         


Ser Val Phe Phe Asn Val Ser Val Leu Asp Pro Thr Ala Arg Leu Gln 
        435                 440                 445             


Leu Glu Ala Arg Leu Gln His Leu Val Ala Glu Ile Leu Glu Arg Glu 
    450                 455                 460                 


Gln Ser Leu Ala Leu His Ala Leu Gly Tyr Gln Leu Ala Phe Val Leu 
465                 470                 475                 480 


Asp Ser Pro Ser Ala Tyr Asp Ala Val Ala Pro Ser Ala Ala His Leu 
                485                 490                 495     


Ile Asp Ala Leu Tyr Ala Glu Phe Leu Gly Gly Arg Val Leu Thr Thr 
            500                 505                 510         


Pro Val Val His Arg Ala Leu Phe Tyr Ala Ser Ala Val Leu Arg Gln 
        515                 520                 525             


Pro Phe Leu Ala Gly Val Pro Ser Ala Val Gln Arg Glu Arg Ala Arg 
    530                 535                 540                 


Arg Ser Leu Leu Ile Ala Ser Ala Leu Cys Thr Ser Asp Val Ala Ala 
545                 550                 555                 560 


Ala Thr Asn Ala Asp Leu Arg Thr Ala Leu Ala Arg Ala Asp His Gln 
                565                 570                 575     


Lys Thr Leu Phe Trp Leu Pro Asp His Phe Ser Pro Cys Ala Ala Ser 
            580                 585                 590         


Leu Arg Phe Asp Leu Asp Glu Ser Val Phe Ile Leu Asp Ala Leu Ala 
        595                 600                 605             


Gln Ala Thr Arg Ser Glu Thr Pro Val Glu Val Leu Ala Gln Gln Thr 
    610                 615                 620                 


His Gly Leu Ala Ser Thr Leu Thr Arg Trp Ala His Tyr Asn Ala Leu 
625                 630                 635                 640 


Ile Arg Ala Phe Val Pro Glu Ala Ser His Arg Cys Gly Gly Gln Ser 
                645                 650                 655     


Ala Asn Val Glu Pro Arg Ile Leu Val Pro Ile Thr His Asn Ala Ser 
            660                 665                 670         


Tyr Val Val Thr His Ser Pro Leu Pro Arg Gly Ile Gly Tyr Lys Leu 
        675                 680                 685             


Thr Gly Val Asp Val Arg Arg Pro Leu Phe Leu Thr Tyr Leu Thr Ala 
    690                 695                 700                 


Thr Cys Glu Gly Ser Thr Arg Asp Ile Glu Ser Lys Arg Leu Val Arg 
705                 710                 715                 720 


Thr Gln Asn Gln Arg Asp Leu Gly Leu Val Gly Ala Val Phe Met Arg 
                725                 730                 735     


Tyr Thr Pro Ala Gly Glu Val Met Ser Val Leu Leu Val Asp Thr Asp 
            740                 745                 750         


Asn Thr Gln Gln Gln Ile Ala Ala Gly Pro Thr Glu Gly Ala Pro Ser 
        755                 760                 765             


Val Phe Ser Ser Asp Val Pro Ser Thr Ala Leu Leu Leu Phe Pro Asn 
    770                 775                 780                 


Gly Thr Val Ile His Leu Leu Ala Phe Asp Thr Gln Pro Val Ala Ala 
785                 790                 795                 800 


Ile Ala Pro Gly Phe Leu Ala Ala Ser Ala Leu Gly Val Val Met Ile 
                805                 810                 815     


Thr Ala Ala Leu Ala Gly Ile Leu Lys Val Leu Arg Thr Ser Val Pro 
            820                 825                 830         


Phe Phe Trp Arg Arg Glu 
        835             


<210>  19
<211>  224
<212>  PRT
<213>  Herpes simplex virus 1 (HHV1)

<400>  19

Met Gly Ile Leu Gly Trp Val Gly Leu Ile Ala Val Gly Val Leu Cys 
1               5                   10                  15      


Val Arg Gly Gly Leu Pro Ser Thr Glu Tyr Val Ile Arg Ser Arg Val 
            20                  25                  30          


Ala Arg Glu Val Gly Asp Ile Leu Lys Val Pro Cys Val Pro Leu Pro 
        35                  40                  45              


Ser Asp Asp Leu Asp Trp Arg Tyr Glu Thr Pro Ser Ala Ile Asn Tyr 
    50                  55                  60                  


Ala Leu Ile Asp Gly Ile Phe Leu Arg Tyr His Cys Pro Gly Leu Asp 
65                  70                  75                  80  


Thr Val Leu Trp Asp Arg His Ala Gln Lys Ala Tyr Trp Val Asn Pro 
                85                  90                  95      


Phe Leu Phe Val Ala Gly Phe Leu Glu Asp Leu Ser Tyr Pro Ala Phe 
            100                 105                 110         


Pro Ala Asn Thr Gln Glu Thr Glu Thr Arg Leu Ala Leu Tyr Lys Glu 
        115                 120                 125             


Ile Arg Gln Ala Leu Asp Ser Arg Lys Gln Ala Ala Ser His Thr Pro 
    130                 135                 140                 


Val Lys Ala Gly Cys Val Asn Phe Asp Tyr Ser Arg Thr Arg Arg Cys 
145                 150                 155                 160 


Val Gly Arg Gln Asp Leu Gly Pro Thr Asn Gly Thr Ser Gly Arg Thr 
                165                 170                 175     


Pro Val Leu Pro Pro Asp Asp Glu Ala Gly Leu Gln Pro Lys Pro Leu 
            180                 185                 190         


Thr Thr Pro Pro Pro Ile Ile Ala Thr Ser Asp Pro Thr Pro Arg Arg 
        195                 200                 205             


Asp Ala Ala Thr Lys Ser Arg Arg Arg Arg Pro His Ser Arg Arg Leu 
    210                 215                 220                 


<210>  20
<211>  581
<212>  PRT
<213>  Hepatitis C Virus

<400>  20

Met Gly Cys Ser Phe Ser Ile Phe Leu Leu Ala Leu Leu Ser Cys Leu 
1               5                   10                  15      


Thr Val Pro Ala Ser Ala Val Glu Val Arg Asn Val Ser Ser Ser Tyr 
            20                  25                  30          


Tyr Ala Thr Asn Asp Cys Ser Asn Ser Ser Ile Thr Trp Gln Leu Asn 
        35                  40                  45              


Asn Ala Val Leu His Leu Pro Gly Cys Val Pro Cys Glu Asn Asp Asn 
    50                  55                  60                  


Gly Thr Leu His Cys Trp Ile Gln Val Thr Pro Asn Val Ala Val Lys 
65                  70                  75                  80  


His Arg Gly Ala Leu Thr His Asn Leu Arg Thr His Val Asp Met Ile 
                85                  90                  95      


Val Met Ala Ala Thr Val Cys Ser Ala Leu Tyr Val Gly Asp Met Cys 
            100                 105                 110         


Gly Ala Val Met Ile Val Ser Gln Ala Leu Ile Ile Ser Pro Glu Arg 
        115                 120                 125             


His Asn Phe Thr Gln Glu Cys Asn Cys Ser Ile Tyr Gln Gly His Ile 
    130                 135                 140                 


Thr Gly His Arg Met Ala Trp Asp Met Met Leu Asn Trp Ser Pro Thr 
145                 150                 155                 160 


Leu Thr Met Ile Leu Ala Tyr Ala Ala Arg Val Pro Glu Leu Val Leu 
                165                 170                 175     


Glu Val Val Phe Gly Gly His Trp Gly Val Val Phe Gly Leu Ala Tyr 
            180                 185                 190         


Phe Ser Met Gln Gly Ala Trp Ala Lys Val Ile Ala Ile Leu Leu Leu 
        195                 200                 205             


Val Ala Gly Val Asp Ala Glu Thr His Thr Thr Gly Ser Ala Ala Gly 
    210                 215                 220                 


His Ala Ala Arg Gly Phe Ala Asn Leu Leu Ser Pro Gly Ser Lys Gln 
225                 230                 235                 240 


Lys Ile Ser Leu Ile Asn Thr Asn Gly Ser Trp His Ile Asn Arg Thr 
                245                 250                 255     


Ala Leu Asn Cys Asn Asp Ser Leu Gln Thr Gly Phe Leu Ala Ser Leu 
            260                 265                 270         


Phe Tyr Val Asn Asn Phe Asn Ser Ser Gly Cys Pro Glu Arg Met Ser 
        275                 280                 285             


Ser Cys Arg Gly Leu Asp Asp Phe Arg Ile Gly Trp Gly Thr Leu Glu 
    290                 295                 300                 


Tyr Glu Thr Asn Val Thr Asn Glu Glu Asp Met Arg Pro Tyr Cys Trp 
305                 310                 315                 320 


His Tyr Pro Pro Lys Pro Cys Gly Ile Ile Ser Ala Arg Thr Val Cys 
                325                 330                 335     


Gly Pro Val Tyr Cys Phe Thr Pro Ser Pro Val Val Val Gly Thr Thr 
            340                 345                 350         


Asp Glu Gln Gly Leu Pro Thr Tyr Ser Trp Gly Glu Asn Glu Thr Asp 
        355                 360                 365             


Val Phe Leu Leu Asn Ser Thr Arg Pro Pro Gln Gly Ala Trp Phe Gly 
    370                 375                 380                 


Cys Thr Trp Met Asn Gly Thr Gly Phe Thr Lys Thr Cys Gly Ala Pro 
385                 390                 395                 400 


Pro Cys Arg Ile Arg Arg Asp Phe Asn Ser Thr Leu Asp Leu Leu Cys 
                405                 410                 415     


Pro Thr Asp Cys Phe Arg Lys His Pro Asp Thr Thr Tyr Leu Lys Cys 
            420                 425                 430         


Gly Ala Gly Pro Trp Leu Thr Pro Arg Cys Leu Val Asp Tyr Pro Tyr 
        435                 440                 445             


Arg Leu Trp His Tyr Pro Cys Thr Val Asn Phe Thr Ile Phe Lys Val 
    450                 455                 460                 


Arg Met Tyr Val Gly Gly Val Glu His Arg Leu Ser Ala Ala Cys Asn 
465                 470                 475                 480 


Phe Thr Arg Gly Asp Arg Cys Arg Leu Glu Asp Arg Asp Arg Gly Gln 
                485                 490                 495     


Gln Ser Pro Leu Leu His Ser Thr Thr Glu Trp Ala Val Leu Pro Cys 
            500                 505                 510         


Ser Phe Ser Asp Leu Pro Ala Leu Ser Thr Gly Leu Leu His Leu His 
        515                 520                 525             


Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly Leu Thr Pro Ala Ile 
    530                 535                 540                 


Thr Lys Tyr Ile Val Lys Trp Glu Trp Val Val Leu Leu Phe Leu Leu 
545                 550                 555                 560 


Leu Ala Asp Ala Arg Val Cys Ala Cys Leu Trp Met Leu Ile Ile Leu 
                565                 570                 575     


Gly Gln Ala Glu Ala 
            580     


<210>  21
<211>  524
<212>  PRT
<213>  Rabies Virus

<400>  21

Met Val Pro Gln Ala Leu Leu Phe Val Pro Leu Leu Val Phe Pro Leu 
1               5                   10                  15      


Cys Phe Gly Lys Phe Pro Ile Tyr Thr Ile Pro Asp Lys Leu Gly Pro 
            20                  25                  30          


Trp Ser Pro Ile Asp Ile His His Leu Ser Cys Pro Asn Asn Leu Val 
        35                  40                  45              


Val Glu Asp Glu Gly Cys Thr Asn Leu Ser Gly Phe Ser Tyr Met Glu 
    50                  55                  60                  


Leu Lys Val Gly Tyr Ile Leu Ala Ile Lys Val Asn Gly Phe Thr Cys 
65                  70                  75                  80  


Thr Gly Val Val Thr Glu Ala Glu Thr Tyr Thr Asn Phe Val Gly Tyr 
                85                  90                  95      


Val Thr Thr Thr Phe Lys Arg Lys His Phe Arg Pro Thr Pro Asp Ala 
            100                 105                 110         


Cys Arg Ala Ala Tyr Asn Trp Lys Met Ala Gly Asp Pro Arg Tyr Glu 
        115                 120                 125             


Glu Ser Leu His Asn Pro Tyr Pro Asp Tyr Arg Trp Leu Arg Thr Val 
    130                 135                 140                 


Lys Thr Thr Lys Glu Ser Leu Val Ile Ile Ser Pro Ser Val Ala Asp 
145                 150                 155                 160 


Leu Asp Pro Tyr Asp Arg Ser Leu His Ser Arg Val Phe Pro Ser Gly 
                165                 170                 175     


Lys Cys Ser Gly Val Ala Val Ser Ser Thr Tyr Cys Ser Thr Asn His 
            180                 185                 190         


Asp Tyr Thr Ile Trp Met Pro Glu Asn Pro Arg Leu Gly Met Ser Cys 
        195                 200                 205             


Asp Ile Phe Thr Asn Ser Arg Gly Lys Arg Ala Ser Lys Gly Ser Glu 
    210                 215                 220                 


Thr Cys Gly Phe Val Asp Glu Arg Gly Leu Tyr Lys Ser Leu Lys Gly 
225                 230                 235                 240 


Ala Cys Lys Leu Lys Leu Cys Gly Val Leu Gly Leu Arg Leu Met Asp 
                245                 250                 255     


Gly Thr Trp Val Ser Met Gln Thr Ser Asn Glu Thr Lys Trp Cys Pro 
            260                 265                 270         


Pro Asp Lys Leu Val Asn Leu His Asp Phe Arg Ser Asp Glu Ile Glu 
        275                 280                 285             


His Leu Val Val Glu Glu Leu Val Arg Lys Arg Glu Glu Cys Leu Asp 
    290                 295                 300                 


Ala Leu Glu Ser Ile Met Thr Thr Lys Ser Val Ser Phe Arg Arg Leu 
305                 310                 315                 320 


Ser His Leu Arg Lys Leu Val Pro Gly Phe Gly Lys Ala Tyr Thr Ile 
                325                 330                 335     


Phe Asn Lys Thr Leu Met Glu Ala Asp Ala His Tyr Lys Ser Val Arg 
            340                 345                 350         


Thr Trp Asn Glu Ile Leu Pro Ser Lys Gly Cys Leu Arg Val Gly Gly 
        355                 360                 365             


Arg Cys His Pro His Val Asn Gly Val Phe Phe Asn Gly Ile Ile Leu 
    370                 375                 380                 


Gly Pro Asp Gly Asn Val Leu Ile Pro Glu Met Gln Ser Ser Leu Leu 
385                 390                 395                 400 


Gln Gln His Met Glu Leu Leu Glu Ser Ser Val Ile Pro Leu Val His 
                405                 410                 415     


Pro Leu Ala Asp Pro Ser Thr Val Phe Lys Asp Gly Asp Glu Ala Glu 
            420                 425                 430         


Asp Phe Val Glu Val His Leu Pro Asp Val His Asn Gln Val Ser Gly 
        435                 440                 445             


Val Asp Leu Gly Leu Pro Asn Trp Gly Lys Tyr Val Leu Leu Ser Ala 
    450                 455                 460                 


Gly Ala Leu Thr Ala Leu Met Leu Ile Ile Phe Leu Met Thr Cys Cys 
465                 470                 475                 480 


Arg Arg Val Asn Arg Ser Glu Pro Thr Gln His Asn Leu Arg Gly Thr 
                485                 490                 495     


Gly Arg Glu Val Ser Val Thr Pro Gln Ser Gly Lys Ile Ile Ser Ser 
            500                 505                 510         


Trp Glu Ser His Lys Ser Gly Gly Glu Thr Arg Leu 
        515                 520                 


<210>  22
<211>  522
<212>  PRT
<213>  Mokola Virus

<400>  22

Met Asn Ile Pro Cys Phe Val Val Ile Leu Ser Leu Ala Thr Thr His 
1               5                   10                  15      


Ser Leu Gly Glu Phe Pro Leu Tyr Thr Ile Pro Glu Lys Ile Glu Lys 
            20                  25                  30          


Trp Thr Pro Ile Asp Met Ile His Leu Ser Cys Pro Asn Asn Leu Leu 
        35                  40                  45              


Ser Glu Glu Glu Gly Cys Asn Ala Glu Ser Ser Phe Thr Tyr Phe Glu 
    50                  55                  60                  


Leu Lys Ser Gly Tyr Leu Ala His Gln Lys Val Pro Gly Phe Thr Cys 
65                  70                  75                  80  


Thr Gly Val Val Asn Glu Ala Glu Thr Tyr Thr Asn Phe Val Gly Tyr 
                85                  90                  95      


Val Thr Thr Thr Phe Lys Arg Lys His Phe Arg Pro Thr Val Ala Ala 
            100                 105                 110         


Cys Arg Asp Ala Tyr Asn Trp Lys Val Ser Gly Asp Pro Arg Tyr Glu 
        115                 120                 125             


Glu Ser Leu His Thr Pro Tyr Pro Asp Ser Ser Trp Leu Arg Thr Val 
    130                 135                 140                 


Thr Thr Thr Lys Glu Ser Leu Leu Ile Ile Ser Pro Ser Ile Val Glu 
145                 150                 155                 160 


Met Asp Ile Tyr Gly Arg Thr Leu His Ser Pro Met Phe Pro Ser Gly 
                165                 170                 175     


Val Cys Ser Asn Val Tyr Pro Ser Val Pro Ser Cys Glu Thr Asn His 
            180                 185                 190         


Asp Tyr Thr Leu Trp Leu Pro Glu Asp Pro Ser Leu Ser Leu Val Cys 
        195                 200                 205             


Asp Ile Phe Thr Ser Ser Asn Gly Lys Lys Ala Met Asn Gly Ser Arg 
    210                 215                 220                 


Ile Cys Gly Phe Lys Asp Glu Arg Gly Phe Tyr Arg Ser Leu Lys Gly 
225                 230                 235                 240 


Ala Cys Lys Leu Thr Leu Cys Gly Arg Pro Gly Ile Arg Leu Phe Asp 
                245                 250                 255     


Gly Thr Trp Val Ser Phe Thr Lys Pro Asp Val His Val Trp Cys Thr 
            260                 265                 270         


Pro Asn Gln Leu Ile Asn Ile His Asn Asp Arg Leu Asp Glu Ile Glu 
        275                 280                 285             


His Leu Ile Val Glu Asp Ile Ile Lys Lys Arg Glu Glu Cys Leu Asp 
    290                 295                 300                 


Thr Leu Glu Thr Ile Leu Met Ser Gln Ser Val Ser Phe Arg Arg Leu 
305                 310                 315                 320 


Ser His Phe Arg Lys Leu Val Pro Gly Tyr Gly Lys Ala Tyr Thr Ile 
                325                 330                 335     


Leu Asn Gly Ser Leu Met Glu Thr Asn Val Tyr Tyr Lys Arg Val Asp 
            340                 345                 350         


Lys Trp Ala Asp Ile Leu Pro Ser Lys Gly Cys Leu Lys Val Gly Gln 
        355                 360                 365             


Gln Cys Met Glu Pro Val Lys Gly Val Leu Phe Asn Gly Ile Ile Lys 
    370                 375                 380                 


Gly Pro Asp Gly Gln Ile Leu Ile Pro Glu Met Gln Ser Glu Gln Leu 
385                 390                 395                 400 


Lys Gln His Met Asp Leu Leu Lys Ala Ala Val Phe Pro Leu Arg His 
                405                 410                 415     


Pro Leu Ile Ser Arg Glu Ala Val Phe Lys Lys Asp Gly Asp Ala Asp 
            420                 425                 430         


Asp Phe Val Asp Leu His Met Pro Asp Val His Lys Ser Val Ser Asp 
        435                 440                 445             


Val Asp Leu Gly Leu Pro His Trp Gly Phe Trp Met Leu Ile Gly Ala 
    450                 455                 460                 


Thr Ile Val Ala Phe Val Val Leu Val Cys Leu Leu Arg Val Cys Cys 
465                 470                 475                 480 


Lys Arg Val Arg Arg Arg Arg Ser Gly Arg Ala Thr Gln Glu Ile Pro 
                485                 490                 495     


Leu Ser Phe Pro Ser Ala Pro Val Pro Arg Ala Lys Val Val Ser Ser 
            500                 505                 510         


Trp Glu Ser Tyr Lys Gly Leu Pro Gly Thr 
        515                 520         


<210>  23
<211>  550
<212>  PRT
<213>  Measles Virus

<400>  23

Met Gly Leu Lys Ala Ser Val Ser Ala Ile Phe Met Thr Val Leu Leu 
1               5                   10                  15      


Thr Leu Gln Thr Pro Thr Gly Gln Ile His Trp Gly Asn Leu Ser Lys 
            20                  25                  30          


Ile Gly Val Val Gly Ile Gly Ser Ala Ser Tyr Lys Val Met Thr Arg 
        35                  40                  45              


Ser Ser His Gln Ser Leu Val Ile Lys Leu Met Pro Asn Ile Thr Leu 
    50                  55                  60                  


Leu Asn Asn Cys Thr Arg Val Glu Ile Ala Glu Tyr Arg Arg Leu Leu 
65                  70                  75                  80  


Arg Thr Val Leu Glu Pro Ile Arg Asp Ala Leu Asn Ala Met Thr Gln 
                85                  90                  95      


Asn Ile Arg Pro Val Gln Ser Val Ala Ser Ser Arg Arg His Lys Arg 
            100                 105                 110         


Phe Ala Gly Val Val Leu Ala Gly Ala Ala Leu Gly Val Ala Thr Ala 
        115                 120                 125             


Ala Gln Ile Thr Ala Gly Ile Ala Leu His Gln Ser Met Leu Asn Ser 
    130                 135                 140                 


Gln Ala Ile Asp Asn Leu Arg Ala Ser Leu Glu Thr Thr Asn Gln Ala 
145                 150                 155                 160 


Ile Glu Thr Ile Arg Gln Ala Gly Gln Glu Met Ile Leu Ala Val Gln 
                165                 170                 175     


Gly Ile Gln Asp Tyr Ile Asn Asn Glu Leu Ile Pro Ser Met Asn Gln 
            180                 185                 190         


Leu Ser Cys Asp Leu Ile Gly Gln Lys Leu Gly Leu Lys Leu Leu Arg 
        195                 200                 205             


Tyr Tyr Thr Glu Ile Leu Ser Leu Phe Gly Pro Ser Leu Arg Asp Pro 
    210                 215                 220                 


Ile Ser Ala Glu Ile Ser Ile Gln Ala Leu Ser Tyr Ala Leu Gly Gly 
225                 230                 235                 240 


Asp Ile Asn Lys Val Leu Glu Lys Leu Gly Tyr Ser Gly Gly Asp Leu 
                245                 250                 255     


Leu Gly Ile Leu Glu Ser Arg Gly Ile Lys Ala Arg Ile Thr His Val 
            260                 265                 270         


Asp Thr Glu Ser Tyr Phe Ile Val Leu Ser Ile Ala Tyr Pro Thr Leu 
        275                 280                 285             


Ser Glu Ile Lys Gly Val Ile Val His Arg Leu Glu Gly Val Ser Tyr 
    290                 295                 300                 


Asn Ile Gly Ser Gln Glu Trp Tyr Thr Thr Val Pro Lys Tyr Val Ala 
305                 310                 315                 320 


Thr Gln Gly Tyr Leu Ile Ser Asn Phe Asp Glu Ser Ser Cys Thr Phe 
                325                 330                 335     


Met Pro Glu Gly Thr Val Cys Ser Gln Asn Ala Leu Tyr Pro Met Ser 
            340                 345                 350         


Pro Leu Leu Gln Glu Cys Leu Arg Gly Ser Thr Lys Ser Cys Ala Arg 
        355                 360                 365             


Thr Leu Val Ser Gly Ser Phe Gly Asn Arg Phe Ile Leu Ser Gln Gly 
    370                 375                 380                 


Asn Leu Ile Ala Asn Cys Ala Ser Ile Leu Cys Lys Cys Tyr Thr Thr 
385                 390                 395                 400 


Gly Thr Ile Ile Asn Gln Asp Pro Asp Lys Ile Leu Thr Tyr Ile Ala 
                405                 410                 415     


Ala Asp Tyr Cys Pro Val Val Glu Val Asn Gly Val Thr Ile Gln Val 
            420                 425                 430         


Gly Ser Arg Lys Tyr Pro Asp Ala Val Tyr Leu His Arg Ile Asp Leu 
        435                 440                 445             


Gly Pro Pro Ile Ser Leu Glu Arg Leu Asp Val Gly Thr Asn Leu Gly 
    450                 455                 460                 


Asn Ala Val Ala Lys Leu Glu Asp Ala Lys Glu Leu Leu Glu Ser Ser 
465                 470                 475                 480 


Asp Gln Ile Leu Arg Ser Met Lys Gly Leu Ser Ser Thr Asn Ile Val 
                485                 490                 495     


Tyr Ile Leu Ile Ala Val Cys Leu Gly Gly Leu Ile Gly Ile Pro Thr 
            500                 505                 510         


Leu Ile Cys Cys Cys Arg Gly Arg Cys Asn Lys Lys Gly Gly Gln Val 
        515                 520                 525             


Gly Met Ser Arg Pro Gly Leu Lys Pro Asp Leu Thr Gly Thr Ser Lys 
    530                 535                 540                 


Ser Tyr Val Arg Ser Leu 
545                 550 


<210>  24
<211>  617
<212>  PRT
<213>  Measles Virus

<400>  24

Met Ser Pro Gln Arg Asp Arg Ile Asn Ala Phe Tyr Lys Asp Asn Pro 
1               5                   10                  15      


His Pro Lys Gly Ser Arg Ile Val Ile Asn Arg Glu His Leu Met Ile 
            20                  25                  30          


Asp Arg Pro Tyr Val Leu Leu Ala Val Leu Phe Val Met Phe Leu Ser 
        35                  40                  45              


Leu Ile Gly Leu Leu Ala Ile Ala Gly Ile Arg Leu His Arg Ala Ala 
    50                  55                  60                  


Ile Tyr Thr Ala Glu Ile His Lys Ser Leu Ser Thr Asn Leu Asp Val 
65                  70                  75                  80  


Thr Asn Ser Ile Glu His Gln Val Lys Asp Val Leu Thr Pro Leu Phe 
                85                  90                  95      


Lys Ile Ile Gly Asp Glu Val Gly Leu Arg Thr Pro Gln Arg Phe Thr 
            100                 105                 110         


Asp Leu Val Lys Phe Ile Ser Asp Lys Ile Lys Phe Leu Asn Pro Asp 
        115                 120                 125             


Arg Glu Tyr Asp Phe Arg Asp Leu Thr Trp Cys Ile Asn Pro Pro Glu 
    130                 135                 140                 


Arg Ile Lys Leu Asp Tyr Asp Gln Tyr Cys Ala Asp Val Ala Ala Glu 
145                 150                 155                 160 


Glu Leu Met Asn Ala Leu Val Asn Ser Thr Leu Leu Glu Thr Arg Thr 
                165                 170                 175     


Thr Asn Gln Phe Leu Ala Val Ser Lys Gly Asn Cys Ser Gly Pro Thr 
            180                 185                 190         


Thr Ile Arg Gly Gln Phe Ser Asn Met Ser Leu Ser Leu Leu Asp Leu 
        195                 200                 205             


Tyr Leu Ser Arg Gly Tyr Asn Val Ser Ser Ile Val Thr Met Thr Ser 
    210                 215                 220                 


Gln Gly Met Tyr Gly Gly Thr Tyr Leu Val Glu Lys Pro Asn Leu Ser 
225                 230                 235                 240 


Ser Lys Gly Ser Glu Leu Pro Gln Pro Ser Met His Arg Val Phe Glu 
                245                 250                 255     


Val Gly Val Ile Arg Asn Pro Gly Leu Gly Ala Pro Val Phe His Met 
            260                 265                 270         


Thr Asn Tyr Phe Glu Gln Pro Val Ser Asn Asp Phe Ser Asn Cys Met 
        275                 280                 285             


Val Ala Leu Gly Glu Leu Lys Leu Ala Ala Leu Cys His Gly Glu Asp 
    290                 295                 300                 


Ser Ile Thr Ile Pro Tyr Gln Gly Ser Gly Lys Gly Val Ser Phe Gln 
305                 310                 315                 320 


Leu Val Lys Leu Gly Val Trp Lys Ser Pro Thr Asp Met Gln Ser Trp 
                325                 330                 335     


Val Pro Leu Ser Thr Asp Asp Pro Val Ile Asp Arg Leu Tyr Leu Ser 
            340                 345                 350         


Ser His Arg Gly Ile Ile Ala Asp Asn Gln Ala Lys Trp Ala Val Pro 
        355                 360                 365             


Thr Thr Arg Thr Asp Asp Lys Leu Arg Met Glu Thr Cys Phe Gln Gln 
    370                 375                 380                 


Ala Cys Lys Gly Lys Ile Gln Ala Leu Cys Glu Asn Pro Glu Trp Ala 
385                 390                 395                 400 


Pro Leu Lys Asp Asn Arg Ile Pro Ser Tyr Gly Val Leu Ser Val Asp 
                405                 410                 415     


Leu Ser Leu Ala Val Glu Leu Lys Ile Lys Ile Ala Ser Gly Phe Gly 
            420                 425                 430         


Pro Leu Ile Thr His Gly Ser Gly Met Asp Leu Tyr Lys Ser Asn His 
        435                 440                 445             


Asn Asn Val Tyr Trp Leu Thr Ile Pro Pro Met Lys Asn Leu Ala Leu 
    450                 455                 460                 


Gly Val Ile Asn Thr Leu Glu Trp Ile Pro Arg Phe Lys Val Ser Pro 
465                 470                 475                 480 


Asn Leu Phe Thr Val Pro Ile Lys Glu Ala Gly Glu Asp Cys His Ala 
                485                 490                 495     


Pro Thr Tyr Leu Pro Ala Glu Val Asp Gly Asp Val Lys Leu Ser Ser 
            500                 505                 510         


Asn Leu Val Ile Leu Pro Gly Gln Asp Leu Gln Tyr Val Leu Ala Thr 
        515                 520                 525             


Tyr Asp Thr Ser Arg Val Glu His Ala Val Val Tyr Tyr Val Tyr Ser 
    530                 535                 540                 


Pro Ser Arg Ser Phe Ser Tyr Phe Tyr Pro Phe Arg Leu Pro Ile Lys 
545                 550                 555                 560 


Gly Val Pro Ile Glu Leu Gln Val Glu Cys Phe Thr Trp Asp Gln Lys 
                565                 570                 575     


Leu Trp Cys Arg His Phe Cys Val Leu Ala Asp Ser Glu Ser Gly Gly 
            580                 585                 590         


His Ile Thr His Ser Gly Met Val Gly Met Gly Val Ser Cys Thr Val 
        595                 600                 605             


Thr Arg Glu Asp Gly Thr Asn Arg Gly 
    610                 615         


<210>  25
<211>  676
<212>  PRT
<213>  Ebola Zaire Virus

<400>  25

Met Gly Val Thr Gly Ile Leu Gln Leu Pro Arg Asp Arg Phe Lys Arg 
1               5                   10                  15      


Thr Ser Phe Phe Leu Trp Val Ile Ile Leu Phe Gln Arg Thr Phe Ser 
            20                  25                  30          


Ile Pro Leu Gly Val Ile His Asn Ser Thr Leu Gln Val Ser Asp Val 
        35                  40                  45              


Asp Lys Leu Val Cys Arg Asp Lys Leu Ser Ser Thr Asn Gln Leu Arg 
    50                  55                  60                  


Ser Val Gly Leu Asn Leu Glu Gly Asn Gly Val Ala Thr Asp Val Pro 
65                  70                  75                  80  


Ser Ala Thr Lys Arg Trp Gly Phe Arg Ser Gly Val Pro Pro Lys Val 
                85                  90                  95      


Val Asn Tyr Glu Ala Gly Glu Trp Ala Glu Asn Cys Tyr Asn Leu Glu 
            100                 105                 110         


Ile Lys Lys Pro Asp Gly Ser Glu Cys Leu Pro Ala Ala Pro Asp Gly 
        115                 120                 125             


Ile Arg Gly Phe Pro Arg Cys Arg Tyr Val His Lys Val Ser Gly Thr 
    130                 135                 140                 


Gly Pro Cys Ala Gly Asp Phe Ala Phe His Lys Glu Gly Ala Phe Phe 
145                 150                 155                 160 


Leu Tyr Asp Arg Leu Ala Ser Thr Val Ile Tyr Arg Gly Thr Thr Phe 
                165                 170                 175     


Ala Glu Gly Val Val Ala Phe Leu Ile Leu Pro Gln Ala Lys Lys Asp 
            180                 185                 190         


Phe Phe Ser Ser His Pro Leu Arg Glu Pro Val Asn Ala Thr Glu Asp 
        195                 200                 205             


Pro Ser Ser Gly Tyr Tyr Ser Thr Thr Ile Arg Tyr Gln Ala Thr Gly 
    210                 215                 220                 


Phe Gly Thr Asn Glu Thr Glu Tyr Leu Phe Glu Val Asp Asn Leu Thr 
225                 230                 235                 240 


Tyr Val Gln Leu Glu Ser Arg Phe Thr Pro Gln Phe Leu Leu Gln Leu 
                245                 250                 255     


Asn Glu Thr Ile Tyr Thr Ser Gly Lys Arg Ser Asn Thr Thr Gly Lys 
            260                 265                 270         


Leu Ile Trp Lys Val Asn Pro Glu Ile Asp Thr Thr Ile Gly Glu Trp 
        275                 280                 285             


Ala Phe Trp Glu Thr Lys Lys Asn Leu Thr Arg Lys Ile Arg Ser Glu 
    290                 295                 300                 


Glu Leu Ser Phe Thr Val Val Ser Asn Gly Ala Lys Asn Ile Ser Gly 
305                 310                 315                 320 


Gln Ser Pro Ala Arg Thr Ser Ser Asp Pro Gly Thr Asn Thr Thr Thr 
                325                 330                 335     


Glu Asp His Lys Ile Met Ala Ser Glu Asn Ser Ser Ala Met Val Gln 
            340                 345                 350         


Val His Ser Gln Gly Arg Glu Ala Ala Val Ser His Leu Thr Thr Leu 
        355                 360                 365             


Ala Thr Ile Ser Thr Ser Pro Gln Ser Leu Thr Thr Lys Pro Gly Pro 
    370                 375                 380                 


Asp Asn Ser Thr His Asn Thr Pro Val Tyr Lys Leu Asp Ile Ser Glu 
385                 390                 395                 400 


Ala Thr Gln Val Glu Gln His His Arg Arg Thr Asp Asn Asp Ser Thr 
                405                 410                 415     


Ala Ser Asp Thr Pro Ser Ala Thr Thr Ala Ala Gly Pro Pro Lys Ala 
            420                 425                 430         


Glu Asn Thr Asn Thr Ser Lys Ser Thr Asp Phe Leu Asp Pro Ala Thr 
        435                 440                 445             


Thr Thr Ser Pro Gln Asn His Ser Glu Thr Ala Gly Asn Asn Asn Thr 
    450                 455                 460                 


His His Gln Asp Thr Gly Glu Glu Ser Ala Ser Ser Gly Lys Leu Gly 
465                 470                 475                 480 


Leu Ile Thr Asn Thr Ile Ala Gly Val Ala Gly Leu Ile Thr Gly Gly 
                485                 490                 495     


Arg Arg Thr Arg Arg Glu Ala Ile Val Asn Ala Gln Pro Lys Cys Asn 
            500                 505                 510         


Pro Asn Leu His Tyr Trp Thr Thr Gln Asp Glu Gly Ala Ala Ile Gly 
        515                 520                 525             


Leu Ala Trp Ile Pro Tyr Phe Gly Pro Ala Ala Glu Gly Ile Tyr Ile 
    530                 535                 540                 


Glu Gly Leu Met His Asn Gln Asp Gly Leu Ile Cys Gly Leu Arg Gln 
545                 550                 555                 560 


Leu Ala Asn Glu Thr Thr Gln Ala Leu Gln Leu Phe Leu Arg Ala Thr 
                565                 570                 575     


Thr Glu Leu Arg Thr Phe Ser Ile Leu Asn Arg Lys Ala Ile Asp Phe 
            580                 585                 590         


Leu Leu Gln Arg Trp Gly Gly Thr Cys His Ile Leu Gly Pro Asp Cys 
        595                 600                 605             


Cys Ile Glu Pro His Asp Trp Thr Lys Asn Ile Thr Asp Lys Ile Asp 
    610                 615                 620                 


Gln Ile Ile His Asp Phe Val Asp Lys Thr Leu Pro Asp Gln Gly Asp 
625                 630                 635                 640 


Asn Asp Asn Trp Trp Thr Gly Trp Arg Gln Trp Ile Pro Ala Gly Ile 
                645                 650                 655     


Gly Val Thr Gly Val Ile Ile Ala Val Ile Ala Leu Phe Cys Ile Cys 
            660                 665                 670         


Lys Phe Val Phe 
        675     


<210>  26
<211>  495
<212>  PRT
<213>  Dengue virus

<400>  26

Met Arg Cys Val Gly Ile Gly Asn Arg Asp Phe Val Glu Gly Leu Ser 
1               5                   10                  15      


Gly Ala Thr Trp Val Asp Val Val Leu Glu His Gly Ser Cys Val Thr 
            20                  25                  30          


Thr Met Ala Lys Asp Lys Pro Thr Leu Asp Ile Glu Leu Leu Lys Thr 
        35                  40                  45              


Glu Val Thr Asn Pro Ala Val Leu Arg Lys Leu Cys Ile Glu Ala Lys 
    50                  55                  60                  


Ile Ser Asn Thr Thr Thr Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 
65                  70                  75                  80  


Thr Leu Val Glu Glu Gln Asp Thr Asn Phe Val Cys Arg Arg Thr Phe 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Leu Ile Thr Cys Ala Lys Phe Lys Cys Val Thr Lys Leu Glu Gly Lys 
        115                 120                 125             


Ile Val Gln Tyr Glu Asn Leu Lys Tyr Ser Val Ile Val Thr Val His 
    130                 135                 140                 


Thr Gly Asp Gln His Gln Val Gly Asn Glu Thr Thr Glu His Gly Thr 
145                 150                 155                 160 


Ile Ala Thr Ile Thr Pro Gln Ala Pro Thr Ser Glu Ile Gln Leu Thr 
                165                 170                 175     


Asp Tyr Gly Ala Leu Thr Leu Asp Cys Ser Pro Arg Thr Gly Leu Asp 
            180                 185                 190         


Phe Asn Glu Met Val Leu Leu Thr Met Lys Glu Lys Ser Trp Leu Val 
        195                 200                 205             


His Lys Gln Trp Phe Leu Asp Leu Pro Leu Pro Trp Thr Ser Gly Ala 
    210                 215                 220                 


Ser Thr Ser Gln Glu Thr Trp Asn Arg Gln Asp Leu Leu Val Thr Phe 
225                 230                 235                 240 


Lys Thr Ala His Ala Lys Lys Gln Glu Val Val Val Leu Gly Ser Gln 
                245                 250                 255     


Glu Gly Ala Met His Thr Ala Leu Thr Gly Ala Thr Glu Ile Gln Thr 
            260                 265                 270         


Ser Gly Thr Thr Thr Ile Phe Ala Gly His Leu Lys Cys Arg Leu Lys 
        275                 280                 285             


Met Asp Lys Leu Thr Leu Lys Gly Ile Ser Tyr Val Met Cys Thr Gly 
    290                 295                 300                 


Ser Phe Lys Leu Glu Lys Glu Val Ala Glu Thr Gln His Gly Thr Val 
305                 310                 315                 320 


Leu Val Gln Val Lys Tyr Glu Gly Thr Asp Ala Pro Cys Lys Ile Pro 
                325                 330                 335     


Phe Ser Ser Gln Asp Glu Lys Gly Val Thr Gln Asn Gly Arg Leu Val 
            340                 345                 350         


Thr Ala Asn Pro Ile Val Thr Asp Lys Glu Lys Pro Val Asn Ile Glu 
        355                 360                 365             


Ala Glu Pro Pro Phe Gly Glu Ser Tyr Ile Val Val Gly Ala Gly Glu 
    370                 375                 380                 


Lys Ala Leu Lys Leu Ser Trp Phe Lys Lys Gly Ser Ser Ile Gly Lys 
385                 390                 395                 400 


Met Phe Glu Ala Thr Ala Arg Gly Ala Arg Arg Met Ala Ile Leu Gly 
                405                 410                 415     


Asp Thr Ala Trp Asp Phe Gly Ser Ile Gly Gly Val Phe Thr Ser Val 
            420                 425                 430         


Gly Lys Leu Val His Gln Ile Phe Gly Thr Ala Tyr Gly Val Leu Phe 
        435                 440                 445             


Ser Gly Val Ser Trp Thr Met Lys Ile Gly Ile Gly Ile Leu Leu Thr 
    450                 455                 460                 


Trp Leu Gly Leu Asn Ser Arg Ser Thr Ser Leu Ser Met Thr Cys Ile 
465                 470                 475                 480 


Ala Val Gly Met Val Thr Leu Tyr Leu Gly Val Met Val Gln Ala 
                485                 490                 495 


<210>  27
<211>  505
<212>  PRT
<213>  Zika virus

<400>  27

Met Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly Met 
1               5                   10                  15      


Ser Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys Val 
            20                  25                  30          


Thr Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val Thr 
        35                  40                  45              


Thr Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu Ala 
    50                  55                  60                  


Ser Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly Glu 
65                  70                  75                  80  


Ala Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg Thr 
                85                  90                  95      


Leu Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly 
            100                 105                 110         


Ser Leu Val Thr Cys Ala Lys Phe Ala Cys Ser Lys Lys Met Thr Gly 
        115                 120                 125             


Lys Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser Val 
    130                 135                 140                 


His Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Thr Gly His Glu 
145                 150                 155                 160 


Thr Asp Glu Asn Arg Ala Lys Val Glu Ile Thr Pro Asn Ser Pro Arg 
                165                 170                 175     


Ala Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys Glu 
            180                 185                 190         


Pro Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met Asn 
        195                 200                 205             


Asn Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro Leu 
    210                 215                 220                 


Pro Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn Lys 
225                 230                 235                 240 


Glu Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr Val 
                245                 250                 255     


Val Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala Gly 
            260                 265                 270         


Ala Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Ser Ser Gly 
        275                 280                 285             


His Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly Val 
    290                 295                 300                 


Ser Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Ile Pro Ala 
305                 310                 315                 320 


Glu Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly Thr 
                325                 330                 335     


Asp Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln Thr 
            340                 345                 350         


Leu Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr Glu 
        355                 360                 365             


Ser Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe Gly 
    370                 375                 380                 


Asp Ser Tyr Ile Val Ile Gly Val Gly Glu Lys Lys Ile Thr His His 
385                 390                 395                 400 


Trp His Arg Ser Gly Ser Thr Ile Gly Lys Ala Phe Glu Ala Thr Val 
                405                 410                 415     


Arg Gly Ala Lys Arg Met Ala Val Leu Gly Asp Thr Ala Trp Asp Phe 
            420                 425                 430         


Gly Ser Val Gly Gly Ala Leu Asn Ser Leu Gly Lys Gly Ile His Gln 
        435                 440                 445             


Ile Phe Gly Ala Ala Phe Lys Ser Leu Phe Gly Gly Met Ser Trp Phe 
    450                 455                 460                 


Ser Gln Ile Leu Ile Gly Thr Leu Leu Met Trp Leu Gly Leu Asn Thr 
465                 470                 475                 480 


Lys Asn Gly Ser Ile Ser Leu Met Cys Leu Ala Leu Gly Gly Val Leu 
                485                 490                 495     


Ile Phe Leu Ser Thr Ala Val Ser Ala 
            500                 505 


<210>  28
<211>  427
<212>  PRT
<213>  West Nile Virus

<400>  28

Met Phe Asn Cys Leu Gly Met Ser Asn Arg Asp Phe Leu Glu Gly Val 
1               5                   10                  15      


Ser Gly Ala Thr Trp Val Asp Leu Val Leu Glu Gly Asp Ser Cys Val 
            20                  25                  30          


Thr Ile Met Ser Lys Asp Lys Pro Thr Ile Asp Val Lys Met Met Asn 
        35                  40                  45              


Met Glu Ala Ala Asn Leu Ala Glu Val Arg Ser Tyr Cys Tyr Leu Ala 
    50                  55                  60                  


Thr Val Ser Asp Leu Ser Thr Lys Ala Ala Cys Pro Thr Met Gly Glu 
65                  70                  75                  80  


Ala His Asn Asp Lys Arg Ala Asp Pro Ala Phe Val Cys Arg Gln Gly 
                85                  90                  95      


Val Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly 
            100                 105                 110         


Ser Ile Asp Thr Cys Ala Lys Phe Ala Cys Ser Thr Lys Ala Ile Gly 
        115                 120                 125             


Arg Thr Ile Leu Lys Glu Asn Ile Lys Tyr Glu Val Ala Ile Phe Val 
    130                 135                 140                 


His Gly Pro Thr Thr Val Glu Ser His Gly Asn Tyr Ser Thr Gln Val 
145                 150                 155                 160 


Gly Ala Thr Gln Ala Gly Arg Phe Ser Ile Thr Pro Ala Ala Pro Ser 
                165                 170                 175     


Tyr Thr Leu Lys Leu Gly Glu Tyr Gly Glu Val Thr Val Asp Cys Glu 
            180                 185                 190         


Pro Arg Ser Gly Ile Asp Thr Asn Ala Tyr Tyr Val Met Thr Val Gly 
        195                 200                 205             


Thr Lys Thr Phe Leu Val His Arg Glu Trp Phe Met Asp Leu Asn Leu 
    210                 215                 220                 


Pro Trp Ser Ser Ala Gly Ser Thr Val Trp Arg Asn Arg Glu Thr Leu 
225                 230                 235                 240 


Met Glu Phe Glu Glu Pro His Ala Thr Lys Gln Ser Val Ile Ala Leu 
                245                 250                 255     


Gly Ser Gln Glu Gly Ala Leu His Gln Ala Leu Ala Gly Ala Ile Pro 
            260                 265                 270         


Val Glu Phe Ser Ser Asn Thr Val Lys Leu Thr Ser Gly His Leu Lys 
        275                 280                 285             


Cys Arg Val Lys Met Glu Lys Leu Gln Leu Lys Gly Thr Thr Tyr Gly 
    290                 295                 300                 


Val Cys Ser Lys Ala Phe Lys Phe Leu Gly Thr Pro Ala Asp Thr Gly 
305                 310                 315                 320 


His Gly Thr Val Val Leu Glu Leu Gln Tyr Thr Gly Thr Asp Gly Pro 
                325                 330                 335     


Cys Lys Val Pro Ile Ser Ser Val Ala Ser Leu Asn Asp Leu Thr Pro 
            340                 345                 350         


Val Gly Arg Leu Val Thr Val Asn Pro Phe Val Ser Val Ala Thr Ala 
        355                 360                 365             


Asn Ala Lys Val Leu Ile Glu Leu Glu Pro Pro Phe Gly Asp Ser Tyr 
    370                 375                 380                 


Ile Val Val Gly Arg Gly Glu Gln Gln Ile Asn His His Trp His Lys 
385                 390                 395                 400 


Ser Gly Ser Ser Ile Gly Lys Ala Phe Thr Thr Thr Leu Lys Gly Ala 
                405                 410                 415     


Gln Arg Leu Ala Ala Leu Gly Asp Thr Ala Trp 
            420                 425         


<210>  29
<211>  501
<212>  PRT
<213>  Japanese Encephalitis Virus

<400>  29

Met Phe Asn Cys Leu Gly Met Gly Asn Arg Asp Phe Ile Glu Gly Ala 
1               5                   10                  15      


Ser Gly Ala Thr Trp Val Asp Leu Val Leu Glu Gly Asp Ser Cys Leu 
            20                  25                  30          


Thr Ile Met Ala Asn Asp Lys Pro Thr Leu Asp Val Arg Met Ile Asn 
        35                  40                  45              


Ile Glu Ala Ser Gln Leu Ala Glu Val Arg Ser Tyr Cys Tyr His Ala 
    50                  55                  60                  


Ser Val Thr Asp Ile Ser Thr Val Ala Arg Cys Pro Thr Thr Gly Glu 
65                  70                  75                  80  


Ala His Asn Glu Lys Arg Ala Asp Ser Ser Tyr Val Cys Lys Gln Gly 
                85                  90                  95      


Phe Thr Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly 
            100                 105                 110         


Ser Ile Asp Thr Cys Ala Lys Phe Ser Cys Thr Ser Lys Ala Ile Gly 
        115                 120                 125             


Arg Thr Ile Gln Pro Glu Asn Ile Lys Tyr Glu Val Gly Ile Phe Val 
    130                 135                 140                 


His Gly Thr Thr Thr Ser Glu Asn His Gly Asn Tyr Ser Ala Gln Val 
145                 150                 155                 160 


Gly Ala Ser Gln Ala Ala Lys Phe Thr Val Thr Pro Asn Ala Pro Ser 
                165                 170                 175     


Ile Thr Leu Lys Leu Gly Asp Tyr Gly Glu Val Thr Leu Asp Cys Glu 
            180                 185                 190         


Pro Arg Ser Gly Leu Asn Thr Glu Ala Phe Tyr Val Met Thr Val Gly 
        195                 200                 205             


Ser Lys Ser Phe Leu Val His Arg Glu Trp Phe His Asp Leu Ala Leu 
    210                 215                 220                 


Pro Trp Thr Ser Pro Ser Ser Thr Ala Trp Arg Asn Arg Glu Leu Leu 
225                 230                 235                 240 


Met Glu Phe Glu Glu Ala His Ala Thr Lys Gln Ser Val Val Ala Leu 
                245                 250                 255     


Gly Ser Gln Glu Gly Gly Leu His Gln Ala Leu Ala Gly Ala Ile Val 
            260                 265                 270         


Val Glu Tyr Ser Ser Ser Val Lys Leu Thr Ser Gly His Leu Lys Cys 
        275                 280                 285             


Arg Leu Lys Met Asp Lys Leu Ala Leu Lys Gly Thr Thr Tyr Gly Met 
    290                 295                 300                 


Cys Thr Gly Lys Phe Ser Phe Ala Lys Asn Pro Ala Asp Thr Gly His 
305                 310                 315                 320 


Gly Thr Val Val Ile Glu Leu Ser Tyr Ser Gly Arg Asp Gly Pro Cys 
                325                 330                 335     


Lys Ile Pro Ile Val Ser Val Ala Ser Leu Asn Asp Met Thr Pro Val 
            340                 345                 350         


Gly Arg Leu Val Thr Val Asn Pro Phe Val Ala Thr Ser Ser Ala Asn 
        355                 360                 365             


Ser Lys Val Leu Val Glu Met Glu Pro Pro Phe Gly Asp Ser Tyr Ile 
    370                 375                 380                 


Val Val Gly Arg Gly Asp Lys Gln Ile Asn His His Trp His Lys Ala 
385                 390                 395                 400 


Gly Ser Thr Leu Gly Lys Ala Phe Ser Thr Thr Leu Lys Gly Ala Gln 
                405                 410                 415     


Arg Leu Ala Ala Leu Gly Asp Thr Ala Trp Asp Phe Gly Ser Ile Gly 
            420                 425                 430         


Gly Val Phe Asn Ser Ile Gly Lys Ala Val His Gln Val Phe Gly Gly 
        435                 440                 445             


Ala Phe Arg Thr Leu Phe Gly Gly Met Ser Trp Ile Thr Gln Gly Leu 
    450                 455                 460                 


Met Gly Ala Leu Leu Leu Trp Met Gly Val Asn Ala Arg Asp Arg Ser 
465                 470                 475                 480 


Ile Ala Leu Ala Phe Leu Ala Thr Gly Gly Val Leu Val Phe Leu Ala 
                485                 490                 495     


Thr Asn Val His Ala 
            500     


<210>  30
<211>  717
<212>  PRT
<213>  Hepatitis G Virus

<400>  30

Met Ser Leu Leu Thr Asn Arg Phe Ile Arg Arg Val Asp Lys Asp Gln 
1               5                   10                  15      


Trp Gly Pro Gly Val Met Gly Lys Asp Pro Lys Pro Cys Pro Ser Arg 
            20                  25                  30          


Trp Ala Gly Lys Cys Met Gly Pro Pro Ser Ser Ala Ala Ala Cys Ser 
        35                  40                  45              


Arg Gly Ser Pro Arg Ile Leu Arg Val Arg Ala Gly Gly Ile Ser Leu 
    50                  55                  60                  


Phe Tyr Thr Ile Met Ala Val Leu Leu Leu Leu Leu Val Val Glu Ala 
65                  70                  75                  80  


Gly Ala Ile Leu Ala Pro Ala Thr His Ala Cys Arg Ala Asn Gly Gln 
                85                  90                  95      


Tyr Phe Leu Thr Asn Cys Cys Ala Pro Glu Asp Ile Gly Phe Cys Leu 
            100                 105                 110         


Glu Gly Gly Cys Leu Val Ala Leu Gly Cys Thr Val Cys Thr Asp Arg 
        115                 120                 125             


Cys Trp Pro Leu Tyr Gln Ala Gly Leu Ala Val Arg Pro Gly Lys Ser 
    130                 135                 140                 


Ala Ala Gln Leu Val Gly Glu Leu Gly Ser Leu Tyr Gly Pro Leu Ser 
145                 150                 155                 160 


Val Ser Ala Tyr Val Ala Gly Ile Leu Gly Leu Gly Glu Val Tyr Ser 
                165                 170                 175     


Gly Val Leu Thr Val Gly Val Ala Leu Arg Arg Arg Val Tyr Leu Met 
            180                 185                 190         


Pro Asn Leu Lys Cys Ala Val Glu Cys Asp Val Lys Trp Gly Ser Glu 
        195                 200                 205             


Phe Trp Arg Trp Thr Glu Gln Leu Ala Ser Asn Tyr Trp Ile Leu Glu 
    210                 215                 220                 


Tyr Leu Trp Lys Val Pro Phe Glu Phe Trp Arg Gly Val Met Ser Leu 
225                 230                 235                 240 


Thr Pro Leu Leu Val Trp Val Ala Ala Leu Leu Leu Leu Glu Gln Arg 
                245                 250                 255     


Ile Val Met Val Phe Leu Leu Val Thr Met Ala Gly Met Leu Gln Gly 
            260                 265                 270         


Ala Pro Ala Ser Val Leu Gly Ser Arg Pro Phe Asp Tyr Gly Leu Lys 
        275                 280                 285             


Trp Gln Ser Cys Ser Cys Arg Ala Asn Gly Ser Arg Ile Pro Thr Gly 
    290                 295                 300                 


Glu Arg Val Trp Asp Arg Gly Asn Val Thr Leu Leu Cys Asp Cys Pro 
305                 310                 315                 320 


Asn Gly Pro Trp Val Trp Val Pro Ala Phe Cys Gln Ala Val Gly Trp 
                325                 330                 335     


Gly Asp Pro Ile Thr His Trp Ser His Gly Gln Asn Gln Trp Pro Leu 
            340                 345                 350         


Ser Cys Pro Gln Tyr Val Tyr Gly Ser Val Ser Val Thr Cys Val Trp 
        355                 360                 365             


Gly Ser Val Ser Trp Phe Ala Ser Thr Gly Gly Arg Asp Ser Lys Ile 
    370                 375                 380                 


Asp Val Trp Ser Leu Val Pro Val Gly Ser Ala Ser Cys Thr Ile Ala 
385                 390                 395                 400 


Ala Leu Gly Ser Ser Asp Arg Asp Thr Val Val Glu Leu Ser Glu Trp 
                405                 410                 415     


Gly Val Pro Cys Val Thr Cys Ile Leu Asp Arg Arg Pro Ala Ser Cys 
            420                 425                 430         


Gly Thr Cys Val Arg Asp Cys Trp Pro Glu Thr Gly Ser Val Arg Phe 
        435                 440                 445             


Pro Phe His Arg Cys Gly Thr Gly Pro Arg Leu Thr Lys Asp Leu Glu 
    450                 455                 460                 


Ala Val Pro Phe Val Asn Arg Thr Thr Pro Phe Thr Ile Arg Gly Pro 
465                 470                 475                 480 


Leu Gly Asn Gln Gly Arg Gly Asn Pro Val Arg Ser Pro Leu Gly Phe 
                485                 490                 495     


Gly Ser Tyr Thr Met Thr Lys Ile Arg Asp Ser Leu His Leu Val Lys 
            500                 505                 510         


Cys Pro Thr Pro Ala Ile Glu Pro Pro Thr Gly Thr Phe Gly Phe Phe 
        515                 520                 525             


Pro Gly Val Pro Pro Ile Asn Asn Cys Met Pro Leu Gly Thr Glu Val 
    530                 535                 540                 


Ser Glu Ala Leu Gly Gly Ala Gly Leu Thr Gly Gly Phe Tyr Glu Pro 
545                 550                 555                 560 


Leu Val Arg Arg Cys Ser Glu Leu Met Gly Arg Arg Asn Pro Val Cys 
                565                 570                 575     


Pro Gly Tyr Ala Trp Leu Ser Ser Gly Arg Pro Asp Gly Phe Ile His 
            580                 585                 590         


Val Gln Gly His Leu Gln Glu Val Asp Ala Gly Asn Phe Ile Pro Pro 
        595                 600                 605             


Pro Arg Trp Leu Leu Leu Asp Phe Val Phe Val Leu Leu Tyr Leu Met 
    610                 615                 620                 


Lys Leu Ala Glu Ala Arg Leu Val Pro Leu Ile Leu Leu Leu Leu Trp 
625                 630                 635                 640 


Trp Trp Val Asn Gln Leu Ala Val Leu Gly Leu Pro Ala Val Asp Ala 
                645                 650                 655     


Ala Val Ala Gly Glu Val Phe Ala Gly Pro Ala Leu Ser Trp Cys Leu 
            660                 665                 670         


Gly Leu Pro Thr Val Ser Met Ile Leu Gly Leu Ala Asn Leu Val Leu 
        675                 680                 685             


Tyr Phe Arg Trp Met Gly Pro Gln Arg Leu Met Phe Leu Val Leu Trp 
    690                 695                 700                 


Lys Leu Ala Arg Gly Leu Asp Leu Asn Ser Pro His Gln 
705                 710                 715         


<210>  31
<211>  539
<212>  PRT
<213>  Mumps Virus

<400>  31

Met Lys Val Phe Leu Val Thr Cys Leu Gly Phe Ala Val Phe Ser Ser 
1               5                   10                  15      


Ser Val Cys Val Asn Ile Asn Ile Leu Gln Gln Ile Gly Tyr Ile Lys 
            20                  25                  30          


Gln Gln Val Arg Gln Leu Ser Tyr Tyr Ser Gln Ser Ser Ser Ser Tyr 
        35                  40                  45              


Ile Val Val Lys Leu Leu Pro Asn Ile Gln Pro Thr Asp Asn Ser Cys 
    50                  55                  60                  


Glu Phe Lys Ser Val Thr Gln Tyr Asn Lys Thr Leu Ser Asn Leu Leu 
65                  70                  75                  80  


Leu Pro Ile Ala Glu Asn Ile Asn Asn Ile Ala Ser Pro Ser Ser Gly 
                85                  90                  95      


Ser Arg Arg His Lys Arg Phe Ala Gly Ile Ala Ile Gly Ile Ala Ala 
            100                 105                 110         


Leu Gly Val Ala Thr Ala Ala Gln Val Thr Ala Ala Val Ser Leu Val 
        115                 120                 125             


Gln Ala Gln Thr Asn Ala Arg Ala Ile Ala Ala Met Lys Asn Ser Ile 
    130                 135                 140                 


Gln Ala Thr Asn Arg Ala Val Phe Glu Val Lys Glu Gly Thr Gln Arg 
145                 150                 155                 160 


Leu Ala Ile Ala Val Gln Ala Ile Gln Asp His Ile Asn Thr Ile Met 
                165                 170                 175     


Asn Thr Gln Leu Asn Asn Met Ser Cys Gln Ile Leu Asp Asn Gln Leu 
            180                 185                 190         


Ala Thr Ser Leu Gly Leu Tyr Leu Thr Glu Leu Thr Thr Val Phe Gln 
        195                 200                 205             


Pro Gln Leu Ile Asn Pro Ala Leu Ser Pro Ile Ser Ile Gln Ala Leu 
    210                 215                 220                 


Arg Ser Leu Leu Gly Ser Met Thr Pro Ala Val Val Gln Ala Thr Leu 
225                 230                 235                 240 


Ser Thr Ser Ile Ser Ala Ala Glu Ile Leu Ser Ala Gly Leu Met Glu 
                245                 250                 255     


Gly Gln Ile Val Ser Val Leu Leu Asp Glu Met Gln Met Ile Val Lys 
            260                 265                 270         


Ile Asn Ile Pro Thr Ile Val Thr Gln Ser Asn Ala Leu Val Ile Asp 
        275                 280                 285             


Phe Tyr Ser Ile Ser Ser Phe Ile Asn Asn Gln Glu Ser Ile Ile Gln 
    290                 295                 300                 


Leu Pro Asp Arg Ile Leu Glu Ile Gly Asn Glu Gln Trp Ser Tyr Pro 
305                 310                 315                 320 


Ala Lys Asn Cys Lys Leu Thr Arg His His Ile Phe Cys Gln Tyr Asn 
                325                 330                 335     


Glu Ala Glu Arg Leu Ser Leu Glu Ser Lys Leu Cys Leu Ala Gly Asn 
            340                 345                 350         


Ile Ser Ala Cys Val Phe Ser Pro Ile Ala Gly Ser Tyr Met Arg Arg 
        355                 360                 365             


Phe Val Ala Leu Asp Gly Thr Ile Val Ala Asn Cys Arg Ser Leu Thr 
    370                 375                 380                 


Cys Leu Cys Lys Ser Pro Ser Tyr Pro Ile Tyr Gln Pro Asp His His 
385                 390                 395                 400 


Ala Val Thr Thr Ile Asp Leu Thr Ala Cys Gln Thr Leu Ser Leu Asp 
                405                 410                 415     


Gly Leu Asp Phe Ser Ile Val Ser Leu Ser Asn Ile Thr Tyr Ala Glu 
            420                 425                 430         


Asn Leu Thr Ile Ser Leu Ser Gln Thr Ile Asn Thr Gln Pro Ile Asp 
        435                 440                 445             


Ile Ser Thr Glu Leu Ser Lys Val Asn Ala Ser Leu Gln Asn Ala Val 
    450                 455                 460                 


Lys Tyr Ile Lys Glu Ser Asn His Gln Leu Gln Ser Val Asn Val Asn 
465                 470                 475                 480 


Ser Lys Ile Gly Ala Ile Ile Val Ala Ala Leu Val Leu Ser Ile Leu 
                485                 490                 495     


Ser Ile Ile Ile Ser Leu Leu Phe Cys Cys Trp Ala Tyr Val Ala Thr 
            500                 505                 510         


Lys Glu Ile Arg Arg Ile Asn Phe Lys Thr Asn His Ile Asn Thr Ile 
        515                 520                 525             


Ser Ser Ser Val Asp Asp Leu Ile Arg Tyr Leu 
    530                 535                 


<210>  32
<211>  583
<212>  PRT
<213>  Mumps Virus

<400>  32

Met Glu Pro Ser Lys Leu Phe Thr Met Ser Asp Asn Ala Thr Phe Ala 
1               5                   10                  15      


Pro Gly Pro Val Ile Asn Ala Ala Asp Lys Lys Thr Phe Arg Thr Cys 
            20                  25                  30          


Phe Arg Ile Leu Val Leu Ser Val Gln Ala Val Thr Leu Ile Leu Val 
        35                  40                  45              


Ile Val Thr Leu Gly Glu Leu Val Arg Met Ile Asn Asp Gln Gly Leu 
    50                  55                  60                  


Ser Asn Gln Leu Ser Ser Ile Ala Asp Lys Ile Arg Glu Ser Ala Thr 
65                  70                  75                  80  


Met Ile Ala Ser Ala Val Gly Val Met Asn Gln Val Ile His Gly Val 
                85                  90                  95      


Thr Val Ser Leu Pro Leu Gln Ile Glu Gly Asn Gln Asn Gln Leu Leu 
            100                 105                 110         


Ser Thr Leu Ala Thr Ile Cys Thr Gly Lys Lys Gln Val Ser Asn Cys 
        115                 120                 125             


Ser Thr Asn Ile Pro Leu Val Asn Asp Leu Arg Phe Ile Asn Gly Ile 
    130                 135                 140                 


Asn Lys Phe Ile Ile Glu Asp Tyr Ala Thr His Asp Phe Ser Ile Gly 
145                 150                 155                 160 


His Pro Leu Asn Met Pro Ser Phe Ile Pro Thr Ala Thr Ser Pro Asn 
                165                 170                 175     


Gly Cys Thr Arg Ile Pro Ser Phe Ser Leu Gly Lys Thr His Trp Cys 
            180                 185                 190         


Tyr Thr His Asn Val Ile Asn Ala Asn Cys Lys Asp His Thr Ser Ser 
        195                 200                 205             


Asn Gln Tyr Ile Ser Met Gly Ile Leu Val Gln Thr Ala Ser Gly Tyr 
    210                 215                 220                 


Pro Met Phe Lys Thr Leu Lys Ile Gln Tyr Leu Ser Asp Gly Leu Asn 
225                 230                 235                 240 


Arg Lys Ser Cys Ser Ile Ala Thr Val Pro Asp Gly Cys Ala Met Tyr 
                245                 250                 255     


Cys Tyr Val Ser Thr Gln Leu Glu Thr Asp Asp Tyr Ala Gly Ser Ser 
            260                 265                 270         


Pro Pro Thr Gln Lys Leu Thr Leu Leu Phe Tyr Asn Asp Thr Val Thr 
        275                 280                 285             


Glu Arg Thr Ile Ser Pro Thr Gly Leu Glu Gly Asn Trp Ala Thr Leu 
    290                 295                 300                 


Val Pro Gly Val Gly Ser Gly Ile Tyr Phe Glu Asn Lys Leu Ile Phe 
305                 310                 315                 320 


Pro Ala Tyr Gly Gly Val Leu Pro Asn Ser Ser Leu Gly Val Lys Ser 
                325                 330                 335     


Ala Arg Glu Phe Phe Arg Pro Val Asn Pro Tyr Asn Pro Cys Ser Gly 
            340                 345                 350         


Pro Gln Gln Asp Leu Asp Gln Arg Ala Leu Arg Ser Tyr Phe Pro Ser 
        355                 360                 365             


Tyr Phe Ser Asn Arg Arg Val Gln Ser Ala Phe Leu Val Cys Ala Trp 
    370                 375                 380                 


Asn Gln Ile Leu Val Thr Asn Cys Glu Leu Val Val Pro Ser Asn Asn 
385                 390                 395                 400 


Gln Thr Leu Met Gly Ala Glu Gly Arg Val Leu Leu Ile Asn Asn Arg 
                405                 410                 415     


Leu Leu Tyr Tyr Gln Arg Ser Thr Ser Trp Trp Pro Tyr Glu Leu Leu 
            420                 425                 430         


Tyr Glu Ile Ser Phe Thr Phe Thr Asn Ser Gly Gln Ser Ser Val Asn 
        435                 440                 445             


Met Ser Trp Ile Pro Ile Tyr Ser Phe Thr Arg Pro Gly Ser Gly Asn 
    450                 455                 460                 


Cys Ser Gly Glu Asn Val Cys Pro Thr Ala Cys Val Ser Gly Val Tyr 
465                 470                 475                 480 


Leu Asp Pro Trp Pro Leu Thr Pro Tyr Ser His Gln Ser Gly Ile Asn 
                485                 490                 495     


Arg Asn Phe Tyr Phe Thr Gly Ala Leu Leu Asn Ser Ser Thr Thr Arg 
            500                 505                 510         


Val Asn Pro Thr Leu Tyr Val Ser Ala Leu Asn Asn Leu Lys Val Leu 
        515                 520                 525             


Ala Pro Tyr Gly Asn Gln Gly Leu Phe Ala Ser Tyr Thr Thr Thr Thr 
    530                 535                 540                 


Cys Phe Gln Asp Thr Gly Asp Ala Ser Val Tyr Cys Val Tyr Ile Met 
545                 550                 555                 560 


Glu Leu Ala Ser Asn Ile Val Gly Glu Phe Gln Ile Leu Pro Val Leu 
                565                 570                 575     


Thr Arg Leu Thr Ile Thr Leu 
            580             


<210>  33
<211>  566
<212>  PRT
<213>  Sendai Virus

<400>  33

Met Thr Ala Tyr Ile Gln Arg Ser Gln Cys Ile Ser Thr Ser Leu Leu 
1               5                   10                  15      


Val Val Leu Thr Thr Leu Val Ser Cys Gln Ile Pro Arg Asp Arg Leu 
            20                  25                  30          


Ser Asn Ile Gly Val Ile Val Asp Glu Gly Lys Ser Leu Lys Ile Ala 
        35                  40                  45              


Gly Ser His Glu Ser Arg Tyr Ile Val Leu Ser Leu Val Pro Gly Val 
    50                  55                  60                  


Asp Phe Glu Asn Gly Cys Gly Thr Ala Gln Val Ile Gln Tyr Lys Ser 
65                  70                  75                  80  


Leu Leu Asn Arg Leu Leu Ile Pro Leu Arg Asp Ala Leu Asp Leu Gln 
                85                  90                  95      


Glu Ala Leu Ile Thr Val Thr Asn Asp Thr Thr Gln Asn Ala Gly Ala 
            100                 105                 110         


Pro Gln Ser Arg Phe Phe Gly Ala Val Ile Gly Thr Ile Ala Leu Gly 
        115                 120                 125             


Val Ala Thr Ser Ala Gln Ile Thr Ala Gly Ile Ala Leu Ala Glu Ala 
    130                 135                 140                 


Arg Glu Ala Lys Arg Asp Ile Ala Leu Ile Lys Glu Ser Met Thr Lys 
145                 150                 155                 160 


Thr His Lys Ser Ile Glu Leu Leu Gln Asn Ala Val Gly Glu Gln Ile 
                165                 170                 175     


Leu Ala Leu Lys Thr Leu Gln Asp Phe Val Asn Asp Glu Ile Lys Pro 
            180                 185                 190         


Ala Ile Ser Glu Leu Gly Cys Glu Thr Ala Ala Leu Arg Leu Gly Ile 
        195                 200                 205             


Lys Leu Thr Gln His Tyr Ser Glu Leu Leu Thr Ala Phe Gly Ser Asn 
    210                 215                 220                 


Phe Gly Thr Ile Gly Glu Lys Ser Leu Thr Leu Gln Ala Leu Ser Ser 
225                 230                 235                 240 


Leu Tyr Ser Ala Asn Ile Thr Glu Ile Met Thr Thr Ile Lys Thr Gly 
                245                 250                 255     


Gln Ser Asn Ile Tyr Asp Val Ile Tyr Thr Glu Gln Ile Lys Gly Thr 
            260                 265                 270         


Val Ile Asp Val Asp Leu Glu Arg Tyr Met Val Thr Leu Ser Val Lys 
        275                 280                 285             


Ile Pro Ile Leu Ser Glu Val Pro Gly Val Leu Ile His Lys Ala Ser 
    290                 295                 300                 


Ser Ile Ser Tyr Asn Ile Asp Gly Glu Glu Trp Tyr Val Thr Val Pro 
305                 310                 315                 320 


Ser His Ile Leu Ser Arg Ala Ser Phe Leu Gly Gly Ala Asp Ile Thr 
                325                 330                 335     


Asp Cys Val Glu Ser Arg Leu Thr Tyr Ile Cys Pro Arg Asp Pro Ala 
            340                 345                 350         


Gln Leu Ile Pro Asp Ser Gln Gln Lys Cys Ile Leu Gly Asp Thr Thr 
        355                 360                 365             


Arg Cys Pro Val Thr Lys Val Val Asp Ser Leu Ile Pro Lys Phe Ala 
    370                 375                 380                 


Phe Val Asn Gly Gly Val Val Ala Asn Cys Ile Ala Ser Thr Cys Thr 
385                 390                 395                 400 


Cys Gly Thr Gly Arg Arg Pro Ile Ser Gln Asp Arg Ser Lys Gly Val 
                405                 410                 415     


Val Phe Leu Thr His Asp Asn Cys Gly Leu Ile Gly Val Asn Gly Val 
            420                 425                 430         


Glu Leu Tyr Ala Asn Arg Arg Gly His Asp Ala Thr Trp Gly Val Gln 
        435                 440                 445             


Asn Leu Thr Val Gly Pro Ala Ile Ala Ile Arg Pro Ile Asp Ile Ser 
    450                 455                 460                 


Leu Asn Leu Ala Asp Ala Thr Asn Phe Leu Gln Asp Ser Lys Ala Glu 
465                 470                 475                 480 


Leu Glu Lys Ala Arg Lys Ile Leu Ser Glu Val Gly Arg Trp Tyr Asn 
                485                 490                 495     


Ser Arg Glu Thr Val Ile Thr Ile Ile Val Val Met Val Val Ile Leu 
            500                 505                 510         


Val Val Ile Ile Val Ile Ile Ile Val Leu Tyr Arg Leu Arg Arg Ser 
        515                 520                 525             


Met Leu Met Gly Asn Pro Asp Asp Arg Ile Pro Arg Asp Thr Tyr Thr 
    530                 535                 540                 


Leu Glu Pro Lys Ile Arg His Met Tyr Thr Asn Gly Gly Phe Asp Ala 
545                 550                 555                 560 


Met Ala Glu Lys Arg Leu 
                565     


<210>  34
<211>  576
<212>  PRT
<213>  Sendai Virus

<400>  34

Met Asp Gly Asp Arg Gly Lys Arg Asp Ser Tyr Trp Ser Thr Ser Pro 
1               5                   10                  15      


Ser Gly Ser Thr Thr Lys Pro Ala Ser Gly Trp Glu Arg Ser Ser Lys 
            20                  25                  30          


Ala Asp Thr Trp Leu Leu Ile Leu Ser Phe Thr Gln Trp Ala Leu Ser 
        35                  40                  45              


Ile Ala Thr Val Ile Ile Cys Ile Ile Ile Ser Ala Arg Gln Gly Tyr 
    50                  55                  60                  


Ser Met Lys Glu Tyr Ser Met Thr Val Glu Ala Leu Asn Met Ser Ser 
65                  70                  75                  80  


Arg Glu Val Lys Glu Ser Leu Thr Ser Leu Ile Arg Gln Glu Val Ile 
                85                  90                  95      


Ala Arg Ala Val Asn Ile Gln Ser Ser Val Gln Thr Gly Ile Pro Val 
            100                 105                 110         


Leu Leu Asn Lys Asn Ser Arg Asp Val Ile Gln Met Ile Asp Lys Ser 
        115                 120                 125             


Cys Ser Arg Gln Glu Leu Thr Gln His Cys Glu Ser Thr Ile Ala Val 
    130                 135                 140                 


His His Ala Asp Gly Ile Ala Pro Leu Glu Pro His Ser Phe Trp Arg 
145                 150                 155                 160 


Cys Pro Val Gly Glu Pro Tyr Leu Ser Ser Asp Pro Glu Ile Ser Leu 
                165                 170                 175     


Leu Pro Gly Pro Ser Leu Leu Ser Gly Ser Thr Thr Ile Ser Gly Cys 
            180                 185                 190         


Val Arg Leu Pro Ser Leu Ser Ile Gly Glu Ala Ile Tyr Ala Tyr Ser 
        195                 200                 205             


Ser Asn Leu Ile Thr Gln Gly Cys Ala Asp Ile Gly Lys Ser Tyr Gln 
    210                 215                 220                 


Val Leu Gln Leu Gly Tyr Ile Ser Leu Asn Ser Asp Met Phe Pro Asp 
225                 230                 235                 240 


Leu Asn Pro Val Val Ser His Thr Tyr Asp Ile Asn Asp Asn Arg Lys 
                245                 250                 255     


Ser Cys Ser Val Val Ala Thr Gly Thr Arg Gly Tyr Gln Leu Cys Ser 
            260                 265                 270         


Met Pro Thr Val Asp Glu Arg Thr Asp Tyr Ser Ser Asp Gly Ile Glu 
        275                 280                 285             


Asp Leu Val Leu Asp Val Leu Asp Leu Lys Gly Arg Thr Lys Ser His 
    290                 295                 300                 


Arg Tyr Arg Asn Ser Glu Val Asp Leu Asp His Pro Phe Ser Ala Leu 
305                 310                 315                 320 


Tyr Pro Ser Val Gly Asn Gly Ile Ala Thr Glu Gly Ser Leu Ile Phe 
                325                 330                 335     


Leu Gly Tyr Gly Gly Leu Thr Thr Pro Leu Gln Gly Asp Thr Lys Cys 
            340                 345                 350         


Arg Thr Gln Gly Cys Gln Gln Val Ser Gln Asp Thr Cys Asn Glu Ala 
        355                 360                 365             


Leu Lys Ile Thr Trp Leu Gly Gly Lys Gln Val Val Ser Val Ile Ile 
    370                 375                 380                 


Gln Val Asn Asp Tyr Leu Ser Glu Arg Pro Lys Ile Arg Val Thr Thr 
385                 390                 395                 400 


Ile Pro Ile Thr Gln Asn Tyr Leu Gly Ala Glu Gly Arg Leu Leu Lys 
                405                 410                 415     


Leu Gly Asp Arg Val Tyr Ile Tyr Thr Arg Ser Ser Gly Trp His Ser 
            420                 425                 430         


Gln Leu Gln Ile Gly Val Leu Asp Val Ser His Pro Leu Thr Ile Asn 
        435                 440                 445             


Trp Thr Pro His Glu Ala Leu Ser Arg Pro Gly Asn Lys Glu Cys Asn 
    450                 455                 460                 


Trp Tyr Asn Lys Cys Pro Lys Glu Cys Ile Ser Gly Val Tyr Thr Asp 
465                 470                 475                 480 


Ala Tyr Pro Leu Ser Pro Asp Ala Ala Asn Val Ala Thr Val Thr Leu 
                485                 490                 495     


Tyr Ala Asn Thr Ser Arg Val Asn Pro Thr Ile Met Tyr Ser Asn Thr 
            500                 505                 510         


Thr Asn Ile Ile Asn Met Leu Arg Ile Lys Asp Val Gln Leu Glu Ala 
        515                 520                 525             


Ala Tyr Thr Thr Thr Ser Cys Ile Thr His Phe Gly Lys Gly Tyr Cys 
    530                 535                 540                 


Phe His Ile Ile Glu Ile Asn Gln Lys Ser Leu Asn Thr Leu Gln Pro 
545                 550                 555                 560 


Met Leu Phe Lys Thr Ser Ile Pro Lys Leu Cys Lys Ala Glu Ser Leu 
                565                 570                 575     


<210>  35
<211>  530
<212>  PRT
<213>  Autographa californica nucleopolyhedrovirus

<400>  35

Met Leu Leu Val Asn Gln Ser His Gln Gly Phe Asn Lys Glu His Thr 
1               5                   10                  15      


Ser Lys Met Val Ser Ala Ile Val Leu Tyr Val Leu Leu Ala Ala Ala 
            20                  25                  30          


Ala His Ser Ala Phe Ala Ala Glu His Cys Asn Ala Gln Met Lys Thr 
        35                  40                  45              


Gly Pro Tyr Lys Ile Lys Asn Leu Asp Ile Thr Pro Pro Lys Glu Thr 
    50                  55                  60                  


Leu Gln Lys Asp Val Glu Ile Thr Ile Val Glu Thr Asp Tyr Asn Glu 
65                  70                  75                  80  


Asn Val Ile Ile Gly Tyr Lys Gly Tyr Tyr Gln Ala Tyr Ala Tyr Asn 
                85                  90                  95      


Gly Gly Ser Leu Asp Pro Asn Thr Arg Val Glu Glu Thr Met Lys Thr 
            100                 105                 110         


Leu Asn Val Gly Lys Glu Asp Leu Leu Met Trp Ser Ile Arg Gln Gln 
        115                 120                 125             


Cys Glu Val Gly Glu Glu Leu Ile Asp Arg Trp Gly Ser Asp Ser Asp 
    130                 135                 140                 


Asp Cys Phe Arg Asp Asn Glu Gly Arg Gly Gln Trp Val Lys Gly Lys 
145                 150                 155                 160 


Glu Leu Val Lys Arg Gln Asn Asn Asn His Phe Ala His His Thr Cys 
                165                 170                 175     


Asn Lys Ser Trp Arg Cys Gly Ile Ser Thr Ser Lys Met Tyr Ser Arg 
            180                 185                 190         


Leu Glu Cys Gln Asp Asp Thr Asp Glu Cys Gln Val Tyr Ile Leu Asp 
        195                 200                 205             


Ala Glu Gly Asn Pro Ile Asn Val Thr Val Asp Thr Val Leu His Arg 
    210                 215                 220                 


Asp Gly Val Ser Met Ile Leu Lys Gln Lys Ser Thr Phe Thr Thr Arg 
225                 230                 235                 240 


Gln Ile Lys Ala Ala Cys Leu Leu Ile Lys Asp Asp Lys Asn Asn Pro 
                245                 250                 255     


Glu Ser Val Thr Arg Glu His Cys Leu Ile Asp Asn Asp Ile Tyr Asp 
            260                 265                 270         


Leu Ser Lys Asn Thr Trp Asn Cys Lys Phe Asn Arg Cys Ile Lys Arg 
        275                 280                 285             


Lys Val Glu His Arg Val Lys Lys Arg Pro Pro Thr Trp Arg His Asn 
    290                 295                 300                 


Val Arg Ala Lys Tyr Thr Glu Gly Asp Thr Ala Thr Lys Gly Asp Leu 
305                 310                 315                 320 


Met His Ile Gln Glu Glu Leu Met Tyr Glu Asn Asp Leu Leu Lys Met 
                325                 330                 335     


Asn Ile Glu Leu Met His Ala His Ile Asn Lys Leu Asn Asn Met Leu 
            340                 345                 350         


His Asp Leu Ile Val Ser Val Ala Lys Val Asp Glu Arg Leu Ile Gly 
        355                 360                 365             


Asn Leu Met Asn Asn Ser Val Ser Ser Thr Phe Leu Ser Asp Asp Thr 
    370                 375                 380                 


Phe Leu Leu Met Pro Cys Thr Asn Pro Pro Ala His Thr Ser Asn Cys 
385                 390                 395                 400 


Tyr Asn Asn Ser Ile Tyr Lys Glu Gly Arg Trp Val Ala Asn Thr Asp 
                405                 410                 415     


Ser Ser Gln Cys Ile Asp Phe Ser Asn Tyr Lys Glu Leu Ala Ile Asp 
            420                 425                 430         


Asp Asp Val Glu Phe Trp Ile Pro Thr Ile Gly Asn Thr Thr Tyr His 
        435                 440                 445             


Asp Ser Trp Lys Asp Ala Ser Gly Trp Ser Phe Ile Ala Gln Gln Lys 
    450                 455                 460                 


Ser Asn Leu Ile Thr Thr Met Glu Asn Thr Lys Phe Gly Gly Val Gly 
465                 470                 475                 480 


Thr Ser Leu Ser Asp Ile Thr Ser Met Ala Glu Gly Glu Leu Ala Ala 
                485                 490                 495     


Lys Leu Thr Ser Phe Met Phe Gly His Val Val Asn Phe Val Ile Ile 
            500                 505                 510         


Leu Ile Val Ile Leu Phe Leu Tyr Cys Met Ile Arg Asn Arg Asn Arg 
        515                 520                 525             


Gln Tyr 
    530 


<210>  36
<211>  985
<212>  PRT
<213>  Ross River Virus

<400>  36

Met Ser Ala Ala Leu Met Met Cys Ile Leu Ala Asn Thr Ser Phe Pro 
1               5                   10                  15      


Cys Ser Ser Pro Pro Cys Tyr Pro Cys Cys Tyr Glu Lys Gln Pro Glu 
            20                  25                  30          


Gln Thr Leu Arg Met Leu Glu Asp Asn Val Asn Arg Pro Gly Tyr Tyr 
        35                  40                  45              


Glu Leu Leu Glu Ala Ser Met Thr Cys Arg Asn Arg Ser Arg His Arg 
    50                  55                  60                  


Arg Ser Val Thr Glu His Phe Asn Val Tyr Lys Ala Thr Arg Pro Tyr 
65                  70                  75                  80  


Leu Ala Tyr Cys Ala Asp Cys Gly Asp Gly Tyr Phe Cys Tyr Ser Pro 
                85                  90                  95      


Val Ala Ile Glu Lys Ile Arg Asp Glu Ala Pro Asp Gly Met Leu Lys 
            100                 105                 110         


Ile Gln Val Ser Ala Gln Ile Gly Leu Asp Lys Ala Gly Thr His Ala 
        115                 120                 125             


His Thr Lys Ile Arg Tyr Met Ala Gly His Asp Val Gln Glu Ser Lys 
    130                 135                 140                 


Arg Asp Ser Leu Arg Val Tyr Thr Ser Ala Ala Cys Ser Ile His Gly 
145                 150                 155                 160 


Thr Met Gly His Phe Ile Val Ala His Cys Pro Pro Gly Asp Tyr Leu 
                165                 170                 175     


Lys Val Ser Phe Glu Asp Ala Asp Ser His Val Lys Ala Cys Lys Val 
            180                 185                 190         


Gln Tyr Lys His Asp Pro Leu Pro Val Gly Arg Glu Lys Phe Val Val 
        195                 200                 205             


Arg Pro His Phe Gly Val Glu Leu Pro Cys Thr Ser Tyr Gln Leu Thr 
    210                 215                 220                 


Thr Ala Pro Thr Asp Glu Glu Ile Asp Met His Thr Pro Pro Asp Ile 
225                 230                 235                 240 


Pro Asp Arg Thr Leu Leu Ser Gln Thr Ala Gly Asn Val Lys Ile Thr 
                245                 250                 255     


Ala Gly Gly Arg Thr Ile Arg Tyr Asn Cys Thr Cys Gly Arg Asp Asn 
            260                 265                 270         


Val Gly Thr Thr Ser Thr Asp Lys Thr Ile Asn Thr Cys Lys Ile Asp 
        275                 280                 285             


Gln Cys His Ala Ala Val Thr Ser His Asp Lys Trp Gln Phe Thr Ser 
    290                 295                 300                 


Pro Phe Val Pro Arg Ala Asp Gln Thr Ala Arg Arg Gly Lys Val His 
305                 310                 315                 320 


Val Pro Phe Pro Leu Thr Asn Val Thr Cys Arg Val Pro Leu Ala Arg 
                325                 330                 335     


Ala Pro Asp Val Thr Tyr Gly Lys Lys Glu Val Thr Leu Arg Leu His 
            340                 345                 350         


Pro Asp His Pro Thr Leu Phe Ser Tyr Arg Ser Leu Gly Ala Glu Pro 
        355                 360                 365             


His Pro Tyr Glu Glu Trp Val Asp Lys Phe Ser Glu Arg Ile Ile Pro 
    370                 375                 380                 


Val Thr Glu Glu Gly Ile Glu Tyr Gln Trp Gly Asn Asn Pro Pro Val 
385                 390                 395                 400 


Arg Leu Trp Ala Gln Leu Thr Thr Glu Gly Lys Pro His Gly Trp Pro 
                405                 410                 415     


His Glu Ile Ile Gln Tyr Tyr Tyr Gly Leu Tyr Pro Ala Ala Thr Ile 
            420                 425                 430         


Ala Ala Val Ser Gly Ala Ser Leu Met Ala Leu Leu Thr Leu Ala Ala 
        435                 440                 445             


Thr Cys Cys Met Leu Ala Thr Ala Arg Arg Lys Cys Leu Thr Pro Tyr 
    450                 455                 460                 


Ala Leu Thr Pro Gly Ala Val Val Pro Leu Thr Leu Gly Leu Leu Cys 
465                 470                 475                 480 


Cys Ala Pro Arg Ala Asn Ala Ala Ser Phe Ala Glu Thr Met Ala Tyr 
                485                 490                 495     


Leu Trp Asp Glu Asn Lys Thr Leu Phe Trp Met Glu Phe Ala Ala Pro 
            500                 505                 510         


Ala Ala Ala Leu Ala Leu Leu Ala Cys Cys Ile Lys Ser Leu Ile Cys 
        515                 520                 525             


Cys Cys Lys Pro Phe Ser Phe Leu Val Leu Leu Ser Leu Gly Ala Ser 
    530                 535                 540                 


Ala Lys Ala Tyr Glu His Thr Ala Thr Ile Pro Asn Val Val Gly Phe 
545                 550                 555                 560 


Pro Tyr Lys Ala His Ile Glu Arg Asn Gly Phe Ser Pro Met Thr Leu 
                565                 570                 575     


Gln Leu Glu Val Val Glu Thr Ser Trp Glu Pro Thr Leu Asn Leu Glu 
            580                 585                 590         


Tyr Ile Thr Cys Glu Tyr Lys Thr Val Val Pro Ser Pro Phe Ile Lys 
        595                 600                 605             


Cys Cys Gly Thr Ser Glu Cys Ser Ser Lys Glu Gln Pro Asp Tyr Gln 
    610                 615                 620                 


Cys Lys Val Tyr Thr Gly Val Tyr Pro Phe Met Trp Gly Gly Ala Tyr 
625                 630                 635                 640 


Cys Phe Cys Asp Ser Glu Asn Thr Gln Leu Ser Glu Ala Tyr Val Asp 
                645                 650                 655     


Arg Ser Asp Val Cys Lys His Asp His Ala Ser Ala Tyr Lys Ala His 
            660                 665                 670         


Thr Ala Ser Leu Lys Ala Thr Ile Arg Ile Ser Tyr Gly Thr Ile Asn 
        675                 680                 685             


Gln Thr Thr Glu Ala Phe Val Asn Gly Glu His Ala Val Asn Val Gly 
    690                 695                 700                 


Gly Ser Lys Phe Ile Phe Gly Pro Ile Ser Thr Ala Trp Ser Pro Phe 
705                 710                 715                 720 


Asp Asn Lys Ile Val Val Tyr Lys Asp Asp Val Tyr Asn Gln Asp Phe 
                725                 730                 735     


Pro Pro Tyr Gly Ser Gly Gln Pro Gly Arg Phe Gly Asp Ile Gln Ser 
            740                 745                 750         


Arg Thr Val Glu Ser Lys Asp Leu Tyr Ala Asn Thr Ala Leu Lys Leu 
        755                 760                 765             


Ser Arg Pro Ser Pro Gly Val Val His Val Pro Tyr Thr Pro Thr Pro 
    770                 775                 780                 


Ser Gly Phe Lys Tyr Trp Leu Lys Glu Lys Gly Ser Ser Leu Asn Thr 
785                 790                 795                 800 


Lys Ala Pro Phe Gly Cys Lys Ile Lys Thr Asn Pro Val Arg Ala Met 
                805                 810                 815     


Asp Cys Ala Val Gly Ser Ile Pro Val Ser Met Asp Ile Pro Asp Ser 
            820                 825                 830         


Ala Phe Thr Arg Val Val Asp Ala Pro Ala Val Thr Asp Leu Ser Cys 
        835                 840                 845             


Gln Val Val Val Cys Thr His Ser Ser Asp Phe Gly Gly Val Ala Thr 
    850                 855                 860                 


Leu Ser Tyr Lys Thr Asp Lys Pro Gly Lys Cys Ala Val His Ser His 
865                 870                 875                 880 


Ser Asn Val Ala Thr Leu Gln Glu Ala Thr Val Asp Val Lys Glu Asp 
                885                 890                 895     


Gly Lys Val Thr Val His Phe Ser Thr Ala Ser Ala Ser Pro Ala Phe 
            900                 905                 910         


Lys Val Ser Val Cys Asp Ala Lys Thr Thr Cys Thr Ala Ala Cys Glu 
        915                 920                 925             


Pro Pro Lys Asp His Ile Val Pro Tyr Gly Ala Ser His Asn Asn Gln 
    930                 935                 940                 


Val Phe Pro Asp Met Ser Gly Thr Ala Met Thr Trp Val Gln Arg Leu 
945                 950                 955                 960 


Ala Ser Gly Leu Gly Gly Leu Ala Leu Ile Ala Val Val Val Leu Val 
                965                 970                 975     


Leu Val Thr Cys Ile Thr Met Arg Arg 
            980                 985 


<210>  37
<211>  524
<212>  PRT
<213>  ArtSeq 	Codon optimized rabies virus

<400>  37

Met Val Pro Gln Ala Leu Leu Phe Val Pro Leu Leu Val Phe Pro Leu 
1               5                   10                  15      


Cys Phe Gly Lys Phe Pro Ile Tyr Thr Ile Pro Asp Lys Leu Gly Pro 
            20                  25                  30          


Trp Ser Pro Ile Asp Ile His His Leu Ser Cys Pro Asn Asn Leu Val 
        35                  40                  45              


Val Glu Asp Glu Gly Cys Thr Asn Leu Ser Gly Phe Ser Tyr Met Glu 
    50                  55                  60                  


Leu Lys Val Gly Tyr Ile Leu Ala Ile Lys Val Asn Gly Phe Thr Cys 
65                  70                  75                  80  


Thr Gly Val Val Thr Glu Ala Glu Thr Tyr Thr Asn Phe Val Gly Tyr 
                85                  90                  95      


Val Thr Thr Thr Phe Lys Arg Lys His Phe Arg Pro Thr Pro Asp Ala 
            100                 105                 110         


Cys Arg Ala Ala Tyr Asn Trp Lys Met Ala Gly Asp Pro Arg Tyr Glu 
        115                 120                 125             


Glu Ser Leu His Asn Pro Tyr Pro Asp Tyr Arg Trp Leu Arg Thr Val 
    130                 135                 140                 


Lys Thr Thr Lys Glu Ser Leu Val Ile Ile Ser Pro Ser Val Ala Asp 
145                 150                 155                 160 


Leu Asp Pro Tyr Asp Arg Ser Leu His Ser Arg Val Phe Pro Ser Gly 
                165                 170                 175     


Lys Cys Ser Gly Val Ala Val Ser Ser Thr Tyr Cys Ser Thr Asn His 
            180                 185                 190         


Asp Tyr Thr Ile Trp Met Pro Glu Asn Pro Arg Leu Gly Met Ser Cys 
        195                 200                 205             


Asp Ile Phe Thr Ser Ser Arg Gly Lys Arg Ala Ser Lys Gly Ser Glu 
    210                 215                 220                 


Thr Cys Gly Phe Val Asp Glu Arg Gly Leu Tyr Lys Ser Leu Lys Gly 
225                 230                 235                 240 


Ala Cys Lys Leu Lys Leu Cys Gly Val Leu Gly Leu Arg Leu Met Asp 
                245                 250                 255     


Gly Thr Trp Val Ser Met Gln Thr Ser Asn Glu Thr Lys Trp Cys Pro 
            260                 265                 270         


Pro Asp Lys Leu Val Asn Leu His Asp Phe Arg Ser Asp Glu Ile Glu 
        275                 280                 285             


His Leu Val Val Glu Glu Leu Val Arg Lys Arg Glu Glu Cys Leu Asp 
    290                 295                 300                 


Ala Leu Glu Ser Ile Met Thr Thr Lys Ser Val Ser Phe Arg Arg Leu 
305                 310                 315                 320 


Ser His Leu Arg Lys Leu Val Pro Gly Phe Gly Lys Ala Tyr Thr Ile 
                325                 330                 335     


Phe Asn Lys Thr Leu Met Glu Ala Asp Ala His Tyr Lys Ser Val Glu 
            340                 345                 350         


Thr Trp Asn Glu Ile Leu Pro Ser Lys Gly Cys Leu Arg Val Gly Gly 
        355                 360                 365             


Arg Cys His Pro His Val Asn Gly Val Phe Phe Asn Gly Ile Ile Leu 
    370                 375                 380                 


Gly Pro Asp Gly Asn Val Leu Ile Pro Glu Met Gln Ser Ser Leu Leu 
385                 390                 395                 400 


Gln Gln His Met Glu Leu Leu Glu Ser Ser Val Ile Pro Leu Val His 
                405                 410                 415     


Pro Leu Ala Asp Pro Ser Thr Val Phe Lys Asp Gly Asp Glu Ala Glu 
            420                 425                 430         


Asp Phe Val Glu Val His Leu Pro Asp Val His Asn Gln Val Ser Gly 
        435                 440                 445             


Val Asp Leu Gly Leu Pro Asn Trp Gly Lys Tyr Val Leu Leu Ser Ala 
    450                 455                 460                 


Gly Ala Leu Thr Ala Leu Met Leu Ile Ile Phe Leu Met Thr Cys Cys 
465                 470                 475                 480 


Arg Arg Val Asn Arg Ser Glu Pro Thr Gln His Asn Leu Arg Gly Thr 
                485                 490                 495     


Gly Arg Glu Val Ser Val Thr Pro Gln Ser Gly Lys Ile Ile Ser Ser 
            500                 505                 510         


Trp Glu Ser His Lys Ser Gly Gly Glu Thr Arg Leu 
        515                 520                 


<210>  38
<211>  524
<212>  PRT
<213>  Rabies virus

<400>  38

Met Val Pro Gln Ala Leu Leu Leu Val Pro Ile Leu Gly Phe Ser Ser 
1               5                   10                  15      


Cys Phe Gly Lys Phe Pro Ile Tyr Thr Ile Pro Asp Thr Leu Gly Pro 
            20                  25                  30          


Trp Ser Pro Ile Asp Ile His His Leu Ser Cys Pro Asn Asn Leu Val 
        35                  40                  45              


Val Glu Asp Glu Gly Cys Thr Asn Leu Ser Gly Phe Ser Tyr Met Glu 
    50                  55                  60                  


Leu Lys Val Gly Tyr Ile Ser Ala Ile Lys Val Asn Gly Phe Thr Cys 
65                  70                  75                  80  


Thr Gly Val Val Thr Glu Ala Glu Thr Tyr Thr Asn Phe Val Gly Tyr 
                85                  90                  95      


Val Thr Thr Thr Phe Lys Arg Lys His Phe Arg Pro Thr Pro Asp Ala 
            100                 105                 110         


Cys Arg Ala Ala Tyr Asn Trp Lys Met Ala Gly Asp Pro Arg Tyr Glu 
        115                 120                 125             


Glu Ser Leu His Ser Pro Tyr Pro Asp Tyr His Trp Leu Arg Thr Val 
    130                 135                 140                 


Lys Thr Thr Lys Glu Ser Leu Val Ile Ile Ser Pro Ser Val Ala Asp 
145                 150                 155                 160 


Leu Asp Pro Tyr Asp Asn Ser Leu His Ser Arg Val Phe Pro Ser Gly 
                165                 170                 175     


Lys Cys Ser Gly Ile Thr Val Ser Ser Val Tyr Cys Ser Thr Asn His 
            180                 185                 190         


Asp Tyr Thr Val Trp Met Pro Glu Ser Leu Arg Leu Gly Thr Ser Cys 
        195                 200                 205             


Asp Ile Phe Thr Asn Ser Arg Gly Lys Arg Ala Ser Lys Gly Ser Lys 
    210                 215                 220                 


Thr Cys Gly Phe Val Asp Glu Arg Gly Leu Tyr Lys Ser Leu Lys Gly 
225                 230                 235                 240 


Ala Cys Lys Leu Lys Leu Cys Gly Val Leu Gly Leu Arg Leu Met Asp 
                245                 250                 255     


Gly Thr Trp Val Ala Met Gln Thr Ser Asn Glu Thr Lys Trp Cys Pro 
            260                 265                 270         


Pro Asp Gln Leu Val Asn Leu His Asp Leu Arg Ser Asp Glu Ile Glu 
        275                 280                 285             


His Leu Val Ile Glu Glu Leu Val Lys Lys Arg Glu Glu Cys Leu Asp 
    290                 295                 300                 


Ala Leu Glu Ser Ile Ile Thr Thr Lys Ser Val Ser Phe Arg Arg Leu 
305                 310                 315                 320 


Ser Tyr Leu Arg Lys Leu Val Pro Gly Phe Gly Lys Ala Tyr Thr Ile 
                325                 330                 335     


Phe Asn Lys Thr Leu Met Glu Ala Glu Ala His Tyr Lys Ser Val Arg 
            340                 345                 350         


Thr Trp Asn Glu Ile Ile Pro Ser Lys Gly Cys Leu Arg Val Gly Gly 
        355                 360                 365             


Arg Cys His Pro His Val Asn Gly Val Phe Phe Asn Gly Ile Ile Leu 
    370                 375                 380                 


Gly Pro Asp Gly His Val Leu Ile Pro Glu Met Gln Ser Ser Leu Leu 
385                 390                 395                 400 


Gln Gln His Ile Glu Leu Leu Glu Ser Ser Val Ile Pro Leu Met His 
                405                 410                 415     


Pro Leu Ala Asp Pro Phe Thr Val Phe Lys Asp Gly Asp Glu Thr Glu 
            420                 425                 430         


Asp Phe Ile Glu Val His Leu Pro Asp Val His Glu Gln Val Ser Gly 
        435                 440                 445             


Val Asp Leu Gly Leu Pro Asn Trp Gly Glu Tyr Val Leu Leu Ser Ala 
    450                 455                 460                 


Gly Thr Leu Ile Ala Leu Met Leu Ile Ile Phe Leu Met Thr Cys Cys 
465                 470                 475                 480 


Arg Lys Val Asp Arg Pro Glu Ser Thr Gln Arg Ser Leu Arg Gly Thr 
                485                 490                 495     


Gly Arg Asn Val Ser Val Thr Ser Gln Ser Gly Lys Phe Ile Pro Ser 
            500                 505                 510         


Trp Glu Ser Tyr Lys Ser Gly Gly Glu Thr Gly Leu 
        515                 520                 


<210>  39
<211>  524
<212>  PRT
<213>  Rabies virus

<400>  39

Met Val Pro Gln Val Leu Leu Phe Val Pro Leu Leu Val Phe Ser Met 
1               5                   10                  15      


Cys Phe Gly Lys Phe Pro Ile Tyr Thr Ile Pro Asp Lys Leu Gly Pro 
            20                  25                  30          


Trp Ser Pro Ile Asp Ile His His Leu Ser Cys Pro Asn Asn Leu Val 
        35                  40                  45              


Val Glu Asp Glu Gly Cys Thr Asn Leu Ser Gly Phe Ser Tyr Met Glu 
    50                  55                  60                  


Leu Lys Val Gly Tyr Ile Ser Ala Ile Lys Val Asn Gly Phe Thr Cys 
65                  70                  75                  80  


Thr Gly Val Val Thr Glu Ala Glu Thr Tyr Thr Asn Phe Val Gly Tyr 
                85                  90                  95      


Val Thr Thr Thr Phe Lys Arg Lys His Phe Arg Pro Thr Pro Asp Ala 
            100                 105                 110         


Cys Arg Ala Ala Tyr Asn Trp Lys Met Ala Gly Asp Pro Arg Tyr Glu 
        115                 120                 125             


Glu Ser Leu His Asn Pro Tyr Pro Asp Tyr His Trp Leu Arg Thr Val 
    130                 135                 140                 


Lys Thr Thr Lys Glu Ser Leu Val Ile Ile Ser Pro Ser Val Ala Asp 
145                 150                 155                 160 


Leu Asp Pro Tyr Asp Lys Ser Leu His Ser Arg Val Phe Pro Ser Gly 
                165                 170                 175     


Lys Cys Ser Gly Ile Thr Ile Ser Ser Thr Tyr Cys Ser Thr Asn His 
            180                 185                 190         


Asp Tyr Thr Ile Trp Met Pro Glu Asn Pro Arg Leu Gly Thr Ser Cys 
        195                 200                 205             


Asp Ile Phe Thr Asn Ser Arg Gly Lys Arg Ala Ser Lys Gly Gly Lys 
    210                 215                 220                 


Thr Cys Gly Phe Val Asp Glu Arg Gly Leu Tyr Lys Ser Leu Lys Gly 
225                 230                 235                 240 


Ala Cys Lys Leu Lys Leu Cys Gly Val Leu Gly Leu Arg Leu Met Asp 
                245                 250                 255     


Gly Thr Trp Val Ala Met Gln Thr Ser Asp Glu Thr Lys Trp Cys Pro 
            260                 265                 270         


Pro Asp Gln Leu Val Asn Leu His Asp Phe Arg Ser Asp Glu Ile Glu 
        275                 280                 285             


His Leu Val Val Glu Glu Leu Val Lys Lys Arg Glu Glu Cys Leu Asp 
    290                 295                 300                 


Ala Leu Glu Ser Ile Met Ala Thr Lys Ser Val Ser Phe Arg Arg Leu 
305                 310                 315                 320 


Ser His Leu Arg Lys Leu Val Pro Gly Phe Gly Lys Ala Tyr Thr Ile 
                325                 330                 335     


Phe Asn Lys Thr Leu Met Glu Ala Asp Ala His Tyr Lys Ser Val Arg 
            340                 345                 350         


Thr Trp Asn Glu Ile Ile Pro Ser Lys Gly Cys Leu Arg Val Gly Gly 
        355                 360                 365             


Arg Cys His Pro His Val Asn Gly Val Phe Phe Asn Gly Ile Ile Leu 
    370                 375                 380                 


Gly Pro Asp Gly His Val Leu Ile Pro Glu Met Gln Ser Ser Leu Leu 
385                 390                 395                 400 


Gln Gln His Met Glu Leu Leu Glu Ser Ser Val Ile Pro Leu Met His 
                405                 410                 415     


Pro Leu Ala Asp Pro Ser Thr Val Phe Lys Asp Gly Asp Glu Ala Glu 
            420                 425                 430         


Asp Phe Val Glu Val His Leu Pro Asp Val His Lys Gln Ile Ser Gly 
        435                 440                 445             


Val Asp Leu Gly Leu Pro Ser Trp Gly Lys Tyr Val Leu Val Ser Ala 
    450                 455                 460                 


Gly Val Leu Val Val Leu Met Leu Thr Ile Phe Ile Met Thr Cys Cys 
465                 470                 475                 480 


Gly Arg Val His Arg Pro Lys Ser Thr Gln His Gly Leu Gly Gly Thr 
                485                 490                 495     


Gly Arg Lys Val Ser Val Thr Ser Gln Ser Gly Lys Val Ile Ser Ser 
            500                 505                 510         


Trp Glu Ser Tyr Lys Ser Gly Gly Glu Thr Arg Leu 
        515                 520                 


<210>  40
<211>  524
<212>  PRT
<213>  Rabies virus

<400>  40

Met Val Pro Gln Val Leu Leu Phe Val Pro Leu Leu Gly Phe Ser Leu 
1               5                   10                  15      


Cys Phe Gly Lys Phe Pro Ile Tyr Thr Ile Pro Asp Lys Leu Gly Pro 
            20                  25                  30          


Trp Ser Pro Ile Asp Ile His His Leu Ser Cys Pro Asn Asn Leu Val 
        35                  40                  45              


Val Glu Asp Glu Gly Cys Thr Asn Leu Ser Glu Phe Ser Tyr Met Glu 
    50                  55                  60                  


Leu Lys Val Gly Tyr Ile Ser Ala Ile Lys Val Asn Gly Phe Thr Cys 
65                  70                  75                  80  


Thr Gly Val Val Thr Glu Ala Glu Thr Tyr Thr Asn Phe Val Gly Tyr 
                85                  90                  95      


Val Thr Thr Thr Phe Lys Arg Lys His Phe Arg Pro Thr Pro Asp Ala 
            100                 105                 110         


Cys Arg Ala Ala Tyr Asn Trp Lys Met Ala Gly Asp Pro Arg Tyr Glu 
        115                 120                 125             


Glu Ser Leu His Asn Pro Tyr Pro Asp Tyr His Trp Leu Arg Thr Val 
    130                 135                 140                 


Arg Thr Thr Lys Glu Ser Leu Ile Ile Ile Ser Pro Ser Val Thr Asp 
145                 150                 155                 160 


Leu Asp Pro Tyr Asp Lys Ser Leu His Ser Arg Val Phe Pro Gly Gly 
                165                 170                 175     


Lys Cys Ser Gly Ile Thr Val Ser Ser Thr Tyr Cys Ser Thr Asn His 
            180                 185                 190         


Asp Tyr Thr Ile Trp Met Pro Glu Asn Pro Arg Pro Arg Thr Pro Cys 
        195                 200                 205             


Asp Ile Phe Thr Asn Ser Arg Gly Lys Arg Ala Ser Lys Gly Asn Lys 
    210                 215                 220                 


Thr Cys Gly Phe Val Asp Glu Arg Gly Leu Tyr Lys Ser Leu Lys Gly 
225                 230                 235                 240 


Ala Cys Arg Leu Lys Leu Cys Gly Val Leu Gly Leu Arg Leu Met Asp 
                245                 250                 255     


Gly Thr Trp Val Ala Met Gln Thr Ser Asp Glu Thr Lys Trp Cys Pro 
            260                 265                 270         


Pro Asp Gln Leu Val Asn Leu His Asp Phe Arg Ser Asp Glu Ile Glu 
        275                 280                 285             


His Leu Val Val Glu Glu Leu Val Lys Lys Arg Glu Glu Cys Leu Asp 
    290                 295                 300                 


Ala Leu Glu Ser Ile Met Thr Thr Lys Ser Val Ser Phe Arg Arg Leu 
305                 310                 315                 320 


Ser His Leu Arg Lys Leu Val Pro Gly Phe Gly Lys Ala Tyr Thr Ile 
                325                 330                 335     


Phe Asn Lys Thr Leu Met Glu Ala Asp Ala His Tyr Lys Ser Val Arg 
            340                 345                 350         


Thr Trp Asn Glu Ile Ile Pro Ser Lys Gly Cys Leu Lys Val Gly Gly 
        355                 360                 365             


Arg Cys His Pro His Val Asn Gly Val Phe Phe Asn Gly Ile Ile Leu 
    370                 375                 380                 


Gly Pro Asp Gly His Val Leu Ile Pro Glu Met Gln Ser Ser Leu Leu 
385                 390                 395                 400 


Gln Gln His Met Glu Leu Leu Lys Ser Ser Val Ile Pro Leu Met His 
                405                 410                 415     


Pro Leu Ala Asp Pro Ser Thr Val Phe Lys Glu Gly Asp Glu Ala Glu 
            420                 425                 430         


Asp Phe Val Glu Val His Leu Pro Asp Val Tyr Lys Gln Ile Ser Gly 
        435                 440                 445             


Val Asp Leu Gly Leu Pro Asn Trp Gly Lys Tyr Val Leu Met Thr Ala 
    450                 455                 460                 


Gly Ala Met Ile Gly Leu Val Leu Ile Phe Ser Leu Met Thr Trp Cys 
465                 470                 475                 480 


Arg Arg Ala Asn Arg Pro Glu Ser Lys Gln Arg Ser Phe Gly Gly Thr 
                485                 490                 495     


Gly Arg Asn Val Ser Val Thr Ser Gln Ser Gly Lys Val Ile Pro Ser 
            500                 505                 510         


Trp Glu Ser Tyr Lys Ser Gly Gly Glu Ile Arg Leu 
        515                 520                 


<210>  41
<211>  524
<212>  PRT
<213>  Rabies virus

<400>  41

Met Val Pro Gln Ala Leu Leu Phe Val Pro Leu Leu Val Phe Pro Leu 
1               5                   10                  15      


Cys Phe Gly Lys Phe Pro Ile Tyr Thr Ile Leu Asp Lys Leu Gly Pro 
            20                  25                  30          


Trp Ser Pro Ile Asp Ile His His Leu Ser Cys Pro Asn Asn Leu Val 
        35                  40                  45              


Val Glu Asp Glu Gly Cys Thr Asn Leu Ser Gly Phe Ser Tyr Met Glu 
    50                  55                  60                  


Leu Lys Val Gly Tyr Ile Leu Ala Ile Lys Met Asn Gly Phe Thr Cys 
65                  70                  75                  80  


Thr Gly Val Val Thr Glu Ala Glu Thr Tyr Thr Asn Phe Val Gly Tyr 
                85                  90                  95      


Val Thr Thr Thr Phe Lys Arg Lys His Phe Arg Pro Thr Pro Asp Ala 
            100                 105                 110         


Cys Arg Ala Ala Tyr Asn Trp Lys Met Ala Gly Asp Pro Arg Tyr Glu 
        115                 120                 125             


Glu Ser Leu His Asn Pro Tyr Pro Asp Tyr Arg Trp Leu Arg Thr Val 
    130                 135                 140                 


Lys Thr Thr Lys Glu Ser Leu Val Ile Ile Ser Pro Ser Val Ala Asp 
145                 150                 155                 160 


Leu Asp Pro Tyr Asp Arg Ser Leu His Ser Arg Val Phe Pro Ser Gly 
                165                 170                 175     


Lys Cys Ser Gly Val Ala Val Ser Ser Thr Tyr Cys Ser Thr Asn His 
            180                 185                 190         


Asp Tyr Thr Ile Trp Met Pro Glu Asn Pro Arg Leu Gly Met Ser Cys 
        195                 200                 205             


Asp Ile Phe Thr Asn Ser Arg Gly Lys Arg Ala Ser Lys Gly Ser Glu 
    210                 215                 220                 


Thr Cys Gly Phe Val Asp Glu Arg Gly Leu Tyr Lys Ser Leu Lys Gly 
225                 230                 235                 240 


Ala Cys Lys Leu Lys Leu Cys Gly Val Leu Gly Leu Arg Leu Met Asp 
                245                 250                 255     


Gly Thr Trp Val Ala Met Gln Thr Ser Asn Glu Thr Lys Trp Cys Pro 
            260                 265                 270         


Pro Asp Gln Leu Val Asn Leu His Asp Phe Arg Ser Asp Glu Ile Glu 
        275                 280                 285             


His Leu Val Val Glu Glu Leu Val Arg Lys Arg Glu Glu Cys Leu Asp 
    290                 295                 300                 


Ala Leu Glu Ser Ile Met Thr Thr Lys Ser Val Ser Phe Arg Arg Leu 
305                 310                 315                 320 


Ser His Leu Arg Lys Leu Val Pro Gly Phe Gly Lys Ala Tyr Thr Ile 
                325                 330                 335     


Phe Asn Lys Thr Leu Met Glu Ala Asp Ala His Tyr Lys Ser Val Arg 
            340                 345                 350         


Thr Trp Asn Glu Ile Leu Pro Ser Lys Gly Cys Leu Arg Val Gly Gly 
        355                 360                 365             


Arg Cys His Pro His Val Asn Gly Val Phe Phe Asn Gly Ile Ile Leu 
    370                 375                 380                 


Gly Pro Asp Gly Asn Val Leu Ile Pro Glu Met Gln Ser Ser Leu Leu 
385                 390                 395                 400 


Gln Gln His Met Glu Leu Leu Glu Ser Ser Val Ile Pro Leu Val His 
                405                 410                 415     


Pro Leu Ala Asp Pro Ser Thr Val Phe Lys Asp Gly Asp Glu Ala Glu 
            420                 425                 430         


Asp Phe Val Glu Val His Leu Pro Asp Val His Asn Gln Val Ser Gly 
        435                 440                 445             


Val Asp Leu Gly Leu Pro Asn Trp Gly Lys Tyr Val Leu Leu Ser Ala 
    450                 455                 460                 


Gly Ala Leu Thr Ala Leu Met Leu Ile Ile Phe Leu Met Thr Cys Cys 
465                 470                 475                 480 


Arg Arg Val Asn Arg Ser Glu Pro Thr Gln His Asn Leu Arg Gly Thr 
                485                 490                 495     


Gly Arg Glu Val Ser Val Thr Pro Gln Ser Gly Lys Ile Ile Ser Ser 
            500                 505                 510         


Trp Glu Ser His Lys Ser Gly Gly Glu Thr Arg Leu 
        515                 520                 


<210>  42
<211>  524
<212>  PRT
<213>  Rabies virus

<400>  42

Met Val Pro Gln Ala Leu Leu Phe Val Pro Leu Leu Val Phe Pro Leu 
1               5                   10                  15      


Cys Phe Gly Lys Phe Pro Ile Tyr Thr Ile Pro Asp Lys Leu Gly Pro 
            20                  25                  30          


Trp Ser Pro Ile Asp Ile His His Leu Ser Cys Pro Asn Asn Leu Val 
        35                  40                  45              


Val Glu Asp Glu Gly Cys Thr Asn Leu Ser Gly Phe Ser Tyr Met Glu 
    50                  55                  60                  


Leu Lys Val Gly Tyr Ile Leu Ala Ile Lys Val Asn Gly Phe Thr Cys 
65                  70                  75                  80  


Thr Gly Val Val Thr Glu Ala Glu Thr Tyr Thr Asn Phe Val Gly Tyr 
                85                  90                  95      


Val Thr Thr Thr Phe Lys Arg Lys His Phe Arg Pro Thr Pro Asp Ala 
            100                 105                 110         


Cys Arg Ala Ala Tyr Asn Trp Lys Met Ala Gly Asp Pro Arg Tyr Glu 
        115                 120                 125             


Glu Ser Leu His Asn Pro Tyr Pro Asp Tyr Arg Trp Leu Arg Thr Val 
    130                 135                 140                 


Lys Thr Thr Lys Glu Ser Leu Val Ile Ile Ser Pro Ser Val Ala Asp 
145                 150                 155                 160 


Leu Asp Pro Tyr Asp Arg Ser Leu His Ser Arg Val Phe Pro Ser Gly 
                165                 170                 175     


Lys Cys Ser Gly Val Ala Val Ser Ser Thr Tyr Cys Ser Thr Asn His 
            180                 185                 190         


Asp Tyr Thr Ile Trp Met Pro Glu Asn Pro Arg Leu Gly Met Ser Cys 
        195                 200                 205             


Asp Ile Phe Thr Asn Ser Arg Gly Lys Arg Ala Ser Lys Gly Ser Glu 
    210                 215                 220                 


Thr Cys Gly Phe Val Asp Glu Arg Gly Leu Tyr Lys Ser Leu Lys Gly 
225                 230                 235                 240 


Ala Cys Lys Leu Lys Leu Cys Gly Val Leu Gly Leu Arg Leu Met Asp 
                245                 250                 255     


Gly Thr Trp Val Ser Met Gln Thr Ser Asn Glu Thr Lys Trp Cys Pro 
            260                 265                 270         


Pro Asp Lys Leu Val Asn Leu His Asp Phe Arg Ser Asp Glu Ile Glu 
        275                 280                 285             


His Leu Val Val Glu Glu Leu Val Arg Lys Arg Glu Glu Cys Leu Asp 
    290                 295                 300                 


Ala Leu Glu Ser Ile Met Thr Thr Lys Ser Val Ser Phe Arg Arg Leu 
305                 310                 315                 320 


Ser His Leu Arg Lys Leu Val Pro Gly Phe Gly Lys Ala Tyr Thr Ile 
                325                 330                 335     


Phe Asn Lys Thr Leu Met Glu Ala Asp Ala His Tyr Lys Ser Val Arg 
            340                 345                 350         


Thr Trp Asn Glu Ile Leu Pro Ser Lys Gly Cys Leu Arg Val Gly Gly 
        355                 360                 365             


Arg Cys His Pro His Val Asn Gly Val Phe Phe Asn Gly Ile Ile Leu 
    370                 375                 380                 


Gly Pro Asp Gly Asn Val Leu Ile Pro Glu Met Gln Ser Ser Leu Leu 
385                 390                 395                 400 


Gln Gln His Met Glu Leu Leu Glu Ser Ser Val Ile Pro Leu Val His 
                405                 410                 415     


Pro Leu Ala Asp Pro Ser Thr Val Phe Lys Asp Gly Asp Glu Ala Glu 
            420                 425                 430         


Asp Phe Val Glu Val His Leu Pro Asp Val His Asn Gln Val Ser Gly 
        435                 440                 445             


Val Asp Leu Gly Leu Pro Asn Trp Gly Lys Tyr Val Leu Leu Ser Ala 
    450                 455                 460                 


Gly Ala Leu Thr Ala Leu Met Leu Ile Ile Phe Leu Met Thr Cys Cys 
465                 470                 475                 480 


Arg Arg Val Asn Arg Ser Glu Pro Thr Gln His Asn Leu Arg Gly Thr 
                485                 490                 495     


Gly Arg Glu Val Ser Val Thr Pro Gln Ser Gly Lys Ile Ile Ser Ser 
            500                 505                 510         


Trp Glu Ser His Lys Ser Gly Gly Glu Thr Arg Leu 
        515                 520                 


<210>  43
<211>  524
<212>  PRT
<213>  Rabies virus

<400>  43

Met Val Pro Gln Ala Leu Leu Phe Val Pro Leu Leu Val Phe Pro Leu 
1               5                   10                  15      


Cys Phe Gly Lys Phe Pro Ile Tyr Thr Ile Pro Asp Lys Leu Gly Pro 
            20                  25                  30          


Trp Ser Pro Ile Asp Ile His His Leu Ser Cys Pro Asn Asn Leu Val 
        35                  40                  45              


Val Glu Asp Glu Gly Cys Thr Asn Leu Ser Gly Phe Ser Tyr Met Glu 
    50                  55                  60                  


Leu Lys Val Gly Tyr Ile Leu Ala Ile Lys Met Asn Gly Phe Thr Cys 
65                  70                  75                  80  


Thr Gly Val Val Thr Glu Ala Glu Asn Tyr Thr Asn Phe Val Gly Tyr 
                85                  90                  95      


Val Thr Thr Thr Phe Lys Arg Lys His Leu Arg Pro Thr Pro Asp Ala 
            100                 105                 110         


Cys Arg Ala Ala Tyr Asn Trp Lys Met Ala Gly Asp Pro Arg Tyr Glu 
        115                 120                 125             


Glu Ser Leu His Asn Pro Tyr Pro Asp Tyr Ser Trp Leu Arg Thr Val 
    130                 135                 140                 


Lys Thr Thr Lys Glu Ser Leu Val Ile Ile Ser Pro Ser Val Ala Asp 
145                 150                 155                 160 


Leu Asp Pro Tyr Asp Arg Ser Leu His Ser Arg Val Phe Pro Ser Gly 
                165                 170                 175     


Lys Cys Ser Gly Val Ala Val Ser Ser Thr Tyr Cys Ser Thr Asn His 
            180                 185                 190         


Asp Tyr Thr Ile Trp Met Pro Glu Asn Pro Arg Leu Gly Lys Ser Cys 
        195                 200                 205             


Asp Ile Phe Thr Asn Ser Arg Gly Lys Arg Ala Ser Lys Gly Ser Glu 
    210                 215                 220                 


Thr Cys Gly Phe Val Asp Glu Arg Gly Leu Tyr Lys Ser Leu Lys Gly 
225                 230                 235                 240 


Ala Cys Lys Leu Lys Leu Cys Gly Val Leu Gly Leu Arg Leu Met Asp 
                245                 250                 255     


Gly Thr Trp Val Ala Met Gln Thr Ser Asn Glu Thr Lys Trp Cys Pro 
            260                 265                 270         


Pro Asp Gln Leu Val Asn Leu His Asp Phe Arg Ser Asp Glu Ile Glu 
        275                 280                 285             


His Leu Val Val Glu Glu Leu Val Arg Lys Arg Glu Glu Cys Leu Asp 
    290                 295                 300                 


Ala Leu Glu Ser Ile Met Thr Thr Lys Ser Val Ser Phe Arg Arg Leu 
305                 310                 315                 320 


Ser His Leu Arg Lys Leu Val Pro Gly Phe Gly Lys Ala Tyr Thr Ile 
                325                 330                 335     


Phe Asn Lys Thr Leu Met Glu Ala Asp Ala His Tyr Lys Ser Val Arg 
            340                 345                 350         


Thr Trp Asn Glu Ile Leu Pro Ser Lys Gly Cys Leu Arg Val Gly Gly 
        355                 360                 365             


Arg Cys His Pro His Val Asn Gly Val Phe Phe Asn Gly Ile Ile Leu 
    370                 375                 380                 


Gly Pro Asp Gly Asn Val Leu Ile Pro Glu Met Gln Ser Ser Leu Leu 
385                 390                 395                 400 


Gln Gln His Met Glu Leu Leu Glu Ser Ser Val Ile Pro Leu Val His 
                405                 410                 415     


Pro Leu Ala Asp Pro Ser Thr Val Phe Lys Asp Gly Asp Glu Ala Glu 
            420                 425                 430         


Asp Phe Val Glu Val His Leu Pro Asp Val His Asn Gln Val Ser Gly 
        435                 440                 445             


Val Asp Leu Gly Leu Pro Asn Trp Gly Lys Tyr Val Leu Leu Ser Ala 
    450                 455                 460                 


Gly Ala Leu Thr Ala Leu Met Leu Ile Ile Phe Leu Met Thr Cys Cys 
465                 470                 475                 480 


Arg Arg Val Asn Arg Ser Glu Pro Thr Gln His Asn Leu Arg Gly Thr 
                485                 490                 495     


Gly Arg Glu Val Ser Val Thr Pro Gln Thr Trp Lys Ile Ile Ser Ser 
            500                 505                 510         


Trp Glu Ser His Lys Ser Gly Gly Glu Thr Arg Leu 
        515                 520                 


<210>  44
<211>  524
<212>  PRT
<213>  Rabies virus

<400>  44

Met Val Pro Gln Ala Leu Leu Phe Val Pro Leu Leu Val Phe Pro Leu 
1               5                   10                  15      


Cys Phe Gly Lys Phe Pro Ile Tyr Thr Ile Pro Asp Lys Leu Gly Pro 
            20                  25                  30          


Trp Ser Pro Ile Asp Ile His His Leu Ser Cys Pro Asn Asn Leu Val 
        35                  40                  45              


Val Glu Asp Glu Gly Cys Thr Asn Leu Ser Gly Phe Ser Tyr Met Glu 
    50                  55                  60                  


Leu Lys Val Gly Tyr Ile Ser Ala Ile Lys Met Asn Gly Phe Thr Cys 
65                  70                  75                  80  


Thr Gly Val Val Thr Glu Ala Glu Thr Tyr Thr Asn Phe Val Gly Tyr 
                85                  90                  95      


Val Thr Thr Thr Phe Lys Arg Lys His Phe Arg Pro Thr Pro Asp Ala 
            100                 105                 110         


Cys Arg Ala Ala Tyr Asn Trp Lys Met Ala Gly Asp Pro Arg Tyr Glu 
        115                 120                 125             


Glu Ser Leu His Asn Pro Tyr Pro Asp Tyr His Trp Leu Arg Thr Val 
    130                 135                 140                 


Lys Thr Thr Lys Glu Ser Leu Val Ile Ile Ser Pro Ser Val Ala Asp 
145                 150                 155                 160 


Leu Asp Pro Tyr Asp Arg Ser Leu His Ser Arg Val Phe Pro Gly Gly 
                165                 170                 175     


Asn Cys Ser Gly Val Ala Val Ser Ser Thr Tyr Cys Ser Thr Asn His 
            180                 185                 190         


Asp Tyr Thr Ile Trp Met Pro Glu Asn Pro Arg Leu Gly Met Ser Cys 
        195                 200                 205             


Asp Ile Phe Thr Asn Ser Arg Gly Lys Arg Ala Ser Lys Gly Ser Glu 
    210                 215                 220                 


Thr Cys Gly Phe Val Asp Glu Arg Gly Leu Tyr Lys Ser Leu Lys Gly 
225                 230                 235                 240 


Ala Cys Lys Leu Lys Leu Cys Gly Val Leu Gly Leu Arg Leu Met Asp 
                245                 250                 255     


Gly Thr Trp Val Ala Met Gln Thr Ser Asn Glu Thr Lys Trp Cys Pro 
            260                 265                 270         


Pro Gly Gln Leu Val Asn Leu His Asp Phe Arg Ser Asp Glu Ile Glu 
        275                 280                 285             


His Leu Val Val Glu Glu Leu Val Lys Lys Arg Glu Glu Cys Leu Asp 
    290                 295                 300                 


Ala Leu Glu Ser Ile Met Thr Thr Lys Ser Val Ser Phe Arg Arg Leu 
305                 310                 315                 320 


Ser His Leu Arg Lys Leu Val Pro Gly Phe Gly Lys Ala Tyr Thr Ile 
                325                 330                 335     


Phe Asn Lys Thr Leu Met Glu Ala Asp Ala His Tyr Lys Ser Val Arg 
            340                 345                 350         


Thr Trp Asn Glu Ile Ile Pro Ser Lys Gly Cys Leu Arg Val Gly Gly 
        355                 360                 365             


Arg Cys His Pro His Val Asn Gly Val Phe Phe Asn Gly Ile Ile Leu 
    370                 375                 380                 


Gly Pro Asp Gly Asn Val Leu Ile Pro Glu Met Gln Ser Ser Leu Leu 
385                 390                 395                 400 


Gln Gln His Met Glu Leu Leu Val Ser Ser Val Ile Pro Leu Met His 
                405                 410                 415     


Pro Leu Ala Asp Pro Ser Thr Val Phe Lys Asn Gly Asp Glu Ala Glu 
            420                 425                 430         


Asp Phe Val Glu Val His Leu Pro Asp Val His Glu Arg Ile Ser Gly 
        435                 440                 445             


Val Asp Leu Gly Leu Pro Asn Trp Gly Lys Tyr Val Leu Leu Ser Ala 
    450                 455                 460                 


Gly Ala Leu Thr Ala Leu Met Leu Ile Ile Phe Leu Met Thr Cys Trp 
465                 470                 475                 480 


Arg Arg Val Asn Arg Ser Glu Pro Thr Gln His Asn Leu Arg Gly Thr 
                485                 490                 495     


Gly Arg Glu Val Ser Val Thr Pro Gln Ser Gly Lys Ile Ile Ser Ser 
            500                 505                 510         


Trp Glu Ser Tyr Lys Ser Gly Gly Glu Thr Gly Leu 
        515                 520                 


<210>  45
<211>  524
<212>  PRT
<213>  Rabies virus

<400>  45

Met Val Pro Gln Val Leu Leu Phe Val Pro Leu Leu Gly Phe Ser Leu 
1               5                   10                  15      


Cys Phe Gly Lys Phe Pro Ile Tyr Thr Ile Pro Asp Glu Leu Gly Pro 
            20                  25                  30          


Trp Ser Pro Ile Asp Ile His His Leu Ser Cys Pro Asn Asn Leu Val 
        35                  40                  45              


Val Glu Asp Glu Gly Cys Thr Asn Leu Ser Glu Phe Ser Tyr Met Glu 
    50                  55                  60                  


Leu Lys Val Gly Tyr Ile Ser Ala Ile Lys Val Asn Gly Phe Thr Cys 
65                  70                  75                  80  


Thr Gly Val Val Thr Glu Ala Glu Thr Tyr Thr Asn Phe Val Gly Tyr 
                85                  90                  95      


Val Thr Thr Thr Phe Lys Arg Lys His Phe Arg Pro Thr Pro Asp Ala 
            100                 105                 110         


Cys Arg Ala Ala Tyr Asn Trp Lys Met Ala Gly Asp Pro Arg Tyr Glu 
        115                 120                 125             


Glu Ser Leu His Asn Pro Tyr Pro Asp Tyr His Trp Leu Arg Thr Val 
    130                 135                 140                 


Arg Thr Thr Lys Glu Ser Leu Ile Ile Ile Ser Pro Ser Val Thr Asp 
145                 150                 155                 160 


Leu Asp Pro Tyr Asp Lys Ser Leu His Ser Arg Gly Phe Pro Gly Gly 
                165                 170                 175     


Lys Cys Ser Gly Ile Thr Val Ser Ser Thr Tyr Cys Ser Thr Asn His 
            180                 185                 190         


Asp Tyr Thr Ile Trp Met Pro Glu Asn Pro Gly Pro Arg Thr Pro Cys 
        195                 200                 205             


Asp Ile Phe Thr Asn Ser Arg Gly Lys Arg Ala Ser Lys Gly Asn Lys 
    210                 215                 220                 


Thr Cys Gly Phe Val Asp Glu Arg Gly Leu Tyr Lys Ser Leu Lys Gly 
225                 230                 235                 240 


Ala Cys Arg Leu Lys Leu Cys Gly Val Leu Gly Leu Arg Leu Met Asp 
                245                 250                 255     


Gly Thr Trp Val Ala Met Gln Thr Ser Asp Glu Thr Lys Trp Cys Pro 
            260                 265                 270         


Pro Asp Gln Leu Val Asn Leu His Asp Phe Arg Ser Asp Glu Ile Glu 
        275                 280                 285             


His Leu Val Val Glu Glu Leu Val Lys Lys Arg Glu Glu Cys Leu Asp 
    290                 295                 300                 


Ala Leu Glu Ser Ile Met Thr Thr Lys Ser Val Ser Phe Arg Arg Leu 
305                 310                 315                 320 


Ser His Leu Arg Lys Leu Val Pro Gly Phe Gly Lys Ala Tyr Thr Ile 
                325                 330                 335     


Phe Asn Lys Thr Leu Met Glu Ala Asp Ala His Tyr Lys Ser Val Arg 
            340                 345                 350         


Thr Trp Asn Glu Ile Ile Pro Ser Lys Gly Cys Leu Lys Val Gly Gly 
        355                 360                 365             


Arg Cys His Pro His Val Asn Gly Val Phe Phe Asn Gly Ile Ile Leu 
    370                 375                 380                 


Gly Pro Asp Gly His Val Leu Ile Pro Glu Met Gln Ser Ser Leu Leu 
385                 390                 395                 400 


Gln Gln His Met Glu Leu Leu Lys Ser Ser Val Ile Pro Leu Met His 
                405                 410                 415     


Pro Leu Ala Asp Pro Ser Thr Val Phe Lys Glu Gly Asp Glu Ala Glu 
            420                 425                 430         


Asp Phe Val Glu Val His Leu Pro Asp Val Tyr Lys Gln Ile Ser Gly 
        435                 440                 445             


Val Asp Leu Gly Leu Pro Asn Trp Gly Lys Tyr Val Leu Met Thr Ala 
    450                 455                 460                 


Gly Ala Met Ile Gly Leu Val Leu Ile Phe Ser Leu Met Thr Trp Cys 
465                 470                 475                 480 


Arg Arg Ala Asn Arg Pro Glu Ser Lys Gln Arg Ser Phe Gly Gly Thr 
                485                 490                 495     


Gly Arg Asn Val Ser Val Thr Ser Gln Ser Gly Lys Val Ile Pro Ser 
            500                 505                 510         


Trp Glu Ser Tyr Arg Ser Gly Gly Glu Ile Arg Leu 
        515                 520                 


<210>  46
<211>  524
<212>  PRT
<213>  Rabies virus

<400>  46

Met Val Pro Gln Ala Leu Leu Leu Val Pro Leu Leu Gly Phe Ser Leu 
1               5                   10                  15      


Cys Phe Gly Lys Phe Pro Ile Tyr Thr Ile Pro Thr Lys Leu Gly Pro 
            20                  25                  30          


Trp Ser Pro Ile Asp Ile His His Leu Ser Cys Pro Asn Asn Leu Val 
        35                  40                  45              


Val Glu Asp Glu Gly Cys Thr Asn Leu Ser Gly Phe Ser Tyr Met Glu 
    50                  55                  60                  


Leu Lys Val Gly Arg Ile Ser Ala Ile Lys Val Asn Gly Phe Thr Cys 
65                  70                  75                  80  


Thr Gly Val Val Thr Glu Ala Glu Thr Tyr Thr Asn Phe Val Gly Tyr 
                85                  90                  95      


Val Thr Thr Thr Phe Lys Arg Lys His Phe Arg Pro Met Pro Gly Cys 
            100                 105                 110         


Met Tyr Ser Arg Val Gln Leu Glu Asp Gly Arg Ser Pro Gln Ile Glu 
        115                 120                 125             


Glu Ser Leu His Asn Pro Tyr Pro Asp Tyr His Trp Leu Arg Thr Val 
    130                 135                 140                 


Arg Thr Thr Lys Glu Ser Leu Ile Ile Ile Ser Pro Ser Val Thr Asp 
145                 150                 155                 160 


Leu Asp Pro Tyr Asp Lys Ser Leu His Ser Arg Val Phe Pro Gly Arg 
                165                 170                 175     


Lys Cys Ser Gly Ile Thr Val Ser Ser Thr Tyr Cys Ser Thr Asn His 
            180                 185                 190         


Asp Tyr Thr Val Trp Met Pro Glu Ile Leu Arg Leu Gly Thr Ser Cys 
        195                 200                 205             


Asp Ile Phe Thr Asn Ser Arg Gly Lys Arg Ala Ser Lys Gly Ser Lys 
    210                 215                 220                 


Thr Cys Gly Phe Val Asp Glu Arg Gly Leu Tyr Lys Ser Leu Lys Gly 
225                 230                 235                 240 


Ala Cys Lys Leu Lys Leu Cys Gly Val Pro Gly Leu Arg Leu Met Asp 
                245                 250                 255     


Gly Thr Trp Val Ala Met Gln Thr Ser Asn Glu Thr Lys Trp Cys Pro 
            260                 265                 270         


Pro Gly Gln Leu Val Asn Leu His Asp Leu His Ser Asp Glu Ile Glu 
        275                 280                 285             


His Leu Val Val Glu Glu Leu Val Lys Lys Arg Glu Glu Cys Leu Asp 
    290                 295                 300                 


Ala Leu Glu Ser Ile Thr Thr Thr Lys Ser Val Ser Phe Arg Arg Leu 
305                 310                 315                 320 


Ser His Leu Arg Lys Leu Val Pro Gly Phe Gly Lys Ala Tyr Thr Ile 
                325                 330                 335     


Phe Asn Lys Thr Leu Met Glu Ala Glu Ala His Tyr Lys Ser Val Arg 
            340                 345                 350         


Thr Trp Asn Glu Ile Ile Pro Ser Lys Gly Cys Leu Arg Val Gly Gly 
        355                 360                 365             


Gly Cys His Pro His Val Asn Gly Val Phe Phe Asn Gly Ile Ile Leu 
    370                 375                 380                 


Gly Pro Asp Gly His Val Leu Ile Pro Glu Met Gln Ser Ser Leu Leu 
385                 390                 395                 400 


Gln Gln His Ile Glu Leu Leu Glu Ser Ser Val Ile Pro Leu Met His 
                405                 410                 415     


Pro Leu Ala Asp Pro Phe Thr Val Phe Lys Asp Gly Asp Glu Ile Glu 
            420                 425                 430         


Asp Phe Val Glu Val His Leu Pro Asp Val His Glu Gln Val Ser Gly 
        435                 440                 445             


Val Asp Leu Gly Leu Pro Asn Trp Gly Glu Tyr Val Leu Leu Ser Ala 
    450                 455                 460                 


Gly Thr Leu Ile Ala Leu Met Leu Ile Ile Phe Leu Ile Thr Cys Cys 
465                 470                 475                 480 


Lys Arg Val Asp Arg Pro Glu Ser Thr Gln Arg Ser Leu Arg Gly Thr 
                485                 490                 495     


Gly Arg Asn Val Ser Val Thr Ser Gln Ser Gly Lys Phe Ile Pro Ser 
            500                 505                 510         


Arg Glu Ser Tyr Lys Ser Gly Gly Glu Thr Gly Leu 
        515                 520                 


<210>  47
<211>  524
<212>  PRT
<213>  Rabies virus

<400>  47

Met Val Pro Gln Val Leu Leu Phe Val Leu Leu Leu Gly Phe Ser Leu 
1               5                   10                  15      


Cys Phe Gly Lys Phe Pro Ile Tyr Thr Ile Pro Asp Glu Leu Gly Pro 
            20                  25                  30          


Trp Ser Pro Ile Asp Ile His His Leu Ser Cys Pro Asn Asn Leu Val 
        35                  40                  45              


Val Glu Asp Glu Gly Cys Thr Asn Leu Ser Glu Phe Ser Tyr Met Glu 
    50                  55                  60                  


Leu Lys Val Gly Tyr Ile Ser Ala Ile Lys Val Asn Gly Phe Thr Cys 
65                  70                  75                  80  


Thr Gly Val Val Thr Glu Ala Glu Thr Tyr Thr Asn Phe Val Gly Tyr 
                85                  90                  95      


Val Thr Thr Thr Phe Lys Arg Lys His Phe Arg Pro Thr Pro Asp Ala 
            100                 105                 110         


Cys Arg Ala Ala Tyr Asn Trp Lys Met Ala Gly Asp Pro Arg Tyr Glu 
        115                 120                 125             


Glu Ser Leu His Asn Pro Tyr Pro Asp Tyr His Trp Leu Arg Thr Val 
    130                 135                 140                 


Arg Thr Thr Lys Glu Ser Leu Ile Ile Ile Ser Pro Ser Val Thr Asp 
145                 150                 155                 160 


Leu Asp Pro Tyr Asp Lys Ser Leu His Ser Arg Val Phe Pro Gly Arg 
                165                 170                 175     


Lys Cys Ser Gly Ile Thr Val Ser Ser Thr Tyr Cys Ser Thr Asn His 
            180                 185                 190         


Asp Tyr Thr Ile Trp Met Pro Glu Asn Pro Arg Pro Arg Thr Pro Cys 
        195                 200                 205             


Asp Ile Phe Thr Asn Ser Arg Gly Lys Arg Ala Ser Asn Gly Asn Lys 
    210                 215                 220                 


Thr Cys Gly Phe Val Asp Glu Arg Gly Leu Tyr Lys Ser Leu Lys Gly 
225                 230                 235                 240 


Ala Cys Arg Leu Lys Leu Cys Gly Val Leu Gly Leu Arg Leu Met Asp 
                245                 250                 255     


Gly Thr Trp Val Ala Met Gln Thr Ser Gly Glu Thr Lys Trp Cys Pro 
            260                 265                 270         


Pro Asp Gln Leu Val Asn Leu His Asp Phe Arg Ser Asp Glu Ile Glu 
        275                 280                 285             


His Leu Val Val Glu Glu Leu Val Lys Lys Arg Glu Glu Cys Leu Asp 
    290                 295                 300                 


Ala Leu Glu Ser Ile Met Thr Thr Lys Ser Val Ser Phe Arg Arg Leu 
305                 310                 315                 320 


Ser His Leu Arg Lys Leu Val Pro Gly Phe Gly Lys Ala Tyr Thr Ile 
                325                 330                 335     


Phe Asn Lys Thr Leu Met Glu Ala Asp Ala His Tyr Lys Ser Val Arg 
            340                 345                 350         


Thr Trp Asn Glu Ile Ile Pro Ser Lys Gly Cys Leu Lys Val Gly Gly 
        355                 360                 365             


Arg Cys His Pro His Val Asn Gly Val Phe Phe Asn Gly Leu Ile Leu 
    370                 375                 380                 


Gly Pro Asp Asp His Val Leu Ile Pro Glu Met Gln Ser Ser Leu Leu 
385                 390                 395                 400 


Gln Gln His Met Glu Leu Leu Glu Ser Ser Val Ile Pro Leu Met His 
                405                 410                 415     


Pro Leu Ala Asp Pro Ser Thr Val Phe Lys Glu Gly Asp Glu Ala Glu 
            420                 425                 430         


Asp Phe Val Glu Val His Leu Pro Asp Val Tyr Lys Gln Ile Ser Gly 
        435                 440                 445             


Val Asp Leu Gly Leu Pro Asn Trp Gly Lys Tyr Val Leu Met Thr Ala 
    450                 455                 460                 


Gly Ala Met Ile Gly Leu Val Leu Ile Phe Ser Leu Met Thr Trp Cys 
465                 470                 475                 480 


Arg Arg Ala Asn Arg Pro Glu Ser Lys Gln Arg Ser Phe Gly Gly Thr 
                485                 490                 495     


Gly Gly Asn Val Ser Val Thr Ser Gln Ser Gly Lys Val Ile Pro Ser 
            500                 505                 510         


Trp Glu Ser Tyr Lys Ser Gly Gly Glu Ile Arg Leu 
        515                 520                 


<210>  48
<211>  524
<212>  PRT
<213>  Rabies virus

<400>  48

Met Val Pro Gln Ala Leu Leu Phe Val Pro Leu Leu Val Phe Pro Leu 
1               5                   10                  15      


Cys Phe Gly Lys Phe Pro Ile Tyr Thr Ile Pro Asp Lys Leu Gly Pro 
            20                  25                  30          


Trp Ser Pro Ile Asp Ile His His Leu Arg Cys Pro Asn Asn Leu Val 
        35                  40                  45              


Val Glu Asp Glu Gly Cys Thr Asn Leu Ser Gly Phe Ser Tyr Met Glu 
    50                  55                  60                  


Leu Lys Val Gly Tyr Ile Ser Ala Ile Lys Val Asn Gly Phe Thr Cys 
65                  70                  75                  80  


Thr Gly Val Val Thr Glu Ala Glu Thr Tyr Thr Asn Phe Val Gly Tyr 
                85                  90                  95      


Val Thr Thr Thr Phe Lys Arg Lys His Phe Arg Pro Thr Pro Asp Ala 
            100                 105                 110         


Cys Arg Ala Ala Tyr Asn Trp Lys Met Ala Gly Asp Pro Arg Tyr Glu 
        115                 120                 125             


Glu Ser Leu His Asn Pro Tyr Pro Asp Tyr His Trp Leu Arg Thr Val 
    130                 135                 140                 


Lys Thr Thr Lys Glu Ser Leu Val Ile Ile Ser Pro Ser Val Ala Asp 
145                 150                 155                 160 


Leu Asp Pro Tyr Asp Lys Ser Leu His Ser Arg Val Phe Pro Ser Gly 
                165                 170                 175     


Asn Cys Ser Gly Ile Thr Val Ser Ser Thr Tyr Cys Ser Thr Asn His 
            180                 185                 190         


Asp Tyr Thr Ile Trp Met Pro Glu Asn Pro Arg Leu Glu Thr Ser Cys 
        195                 200                 205             


Asp Ile Phe Thr Asn Ser Arg Gly Lys Arg Ala Ser Lys Gly Ser Lys 
    210                 215                 220                 


Thr Cys Gly Phe Val Asp Glu Arg Gly Leu Tyr Lys Ser Leu Lys Gly 
225                 230                 235                 240 


Ala Cys Lys Leu Lys Leu Cys Gly Val Leu Gly Leu Arg Leu Met Asp 
                245                 250                 255     


Gly Thr Trp Val Ala Met Gln Thr Ser Asp Glu Thr Lys Trp Cys Pro 
            260                 265                 270         


Pro Asp Gln Leu Val Asn Leu His Asp Phe Arg Ser Asp Glu Ile Glu 
        275                 280                 285             


His Leu Val Val Glu Glu Leu Val Lys Lys Arg Glu Glu Cys Leu Asp 
    290                 295                 300                 


Ala Leu Glu Ser Ile Met Thr Thr Lys Ser Val Ser Leu Arg Arg Leu 
305                 310                 315                 320 


Ser His Leu Arg Lys Leu Val Pro Gly Phe Gly Lys Ala Tyr Thr Ile 
                325                 330                 335     


Phe Asn Lys Thr Leu Met Glu Ala Glu Ala His Tyr Lys Ser Val Gln 
            340                 345                 350         


Thr Trp Asn Glu Ile Ile Pro Ser Lys Gly Cys Leu Arg Val Gly Gly 
        355                 360                 365             


Arg Cys His Pro His Val Asn Gly Val Phe Phe Asn Gly Ile Ile Leu 
    370                 375                 380                 


Gly Pro Asp Gly His Val Leu Ile Pro Glu Met Gln Ser Ser Leu Leu 
385                 390                 395                 400 


Gln Gln His Met Glu Leu Leu Glu Ser Ser Val Ile Pro Leu Met His 
                405                 410                 415     


Pro Leu Ala Asp Pro Ser Thr Val Phe Lys Asp Gly Asp Glu Ala Glu 
            420                 425                 430         


Asp Phe Val Glu Val His Leu Pro Asp Val His Lys Gln Val Ser Gly 
        435                 440                 445             


Val Asp Leu Gly Leu Pro Asn Trp Gly Lys Tyr Val Leu Leu Ser Ala 
    450                 455                 460                 


Gly Thr Leu Ile Ala Leu Met Leu Ile Ile Phe Leu Met Thr Cys Cys 
465                 470                 475                 480 


Arg Arg Val Asn Arg Pro Lys Ser Thr Glu Arg Ser Leu Gly Glu Thr 
                485                 490                 495     


Gly Arg Lys Val Ser Val Thr Ser Gln Ser Gly Lys Val Ile Ser Ser 
            500                 505                 510         


Trp Glu Ser Tyr Lys Ser Gly Gly Glu Thr Arg Arg 
        515                 520                 


<210>  49
<211>  524
<212>  PRT
<213>  Rabies virus

<400>  49

Met Val Pro Gln Val Leu Leu Phe Ala Pro Leu Leu Val Phe Pro Leu 
1               5                   10                  15      


Cys Phe Gly Lys Phe Pro Ile Tyr Thr Ile Pro Asp Lys Leu Gly Pro 
            20                  25                  30          


Trp Ser Pro Ile Asp Leu His His Leu Ser Cys Pro Asn Asn Leu Val 
        35                  40                  45              


Val Glu Asp Glu Gly Cys Thr Asn Leu Ser Gly Phe Ser Tyr Met Glu 
    50                  55                  60                  


Leu Lys Val Gly Tyr Ile Ser Ala Ile Lys Val Asn Gly Phe Thr Cys 
65                  70                  75                  80  


Thr Gly Val Val Thr Glu Ala Glu Thr Tyr Thr Asn Phe Val Gly Tyr 
                85                  90                  95      


Val Thr Thr Thr Phe Lys Arg Lys His Phe Arg Pro Thr Pro Asp Ala 
            100                 105                 110         


Cys Arg Ala Ala Tyr Asn Trp Lys Met Ala Gly Asp Pro Arg Tyr Glu 
        115                 120                 125             


Glu Ser Leu His Asn Pro Tyr Pro Asp Tyr His Trp Leu Arg Thr Val 
    130                 135                 140                 


Lys Thr Thr Lys Glu Ser Leu Val Ile Ile Ser Pro Ser Val Thr Asp 
145                 150                 155                 160 


Leu Asp Pro Tyr Asp Lys Ser Leu His Ser Arg Val Phe Pro Gly Gly 
                165                 170                 175     


Asn Cys Ser Gly Ile Thr Val Ser Ser Thr Tyr Cys Ser Thr Asn His 
            180                 185                 190         


Asp Tyr Thr Ile Trp Met Pro Glu Asn Leu Arg Leu Gly Thr Ser Cys 
        195                 200                 205             


Asp Ile Phe Thr His Ser Arg Gly Lys Arg Ala Ser Lys Gly Asp Lys 
    210                 215                 220                 


Thr Cys Gly Phe Val Asp Glu Arg Gly Leu Tyr Lys Ser Leu Lys Gly 
225                 230                 235                 240 


Ala Cys Lys Leu Lys Leu Cys Gly Val Leu Gly Leu Arg Leu Met Asp 
                245                 250                 255     


Gly Thr Trp Val Ala Met Gln Thr Ser Asp Glu Thr Lys Trp Cys Pro 
            260                 265                 270         


Pro Gly Gln Leu Val Asn Leu His Asp Phe Arg Ser Asp Glu Ile Glu 
        275                 280                 285             


His Leu Val Glu Glu Glu Leu Val Lys Lys Arg Glu Glu Cys Leu Asp 
    290                 295                 300                 


Ala Leu Glu Ser Ile Met Thr Thr Lys Ser Val Ser Phe Arg Arg Leu 
305                 310                 315                 320 


Ser His Leu Arg Lys Leu Val Pro Gly Phe Gly Lys Ala Tyr Thr Ile 
                325                 330                 335     


Phe Asn Lys Thr Leu Met Glu Ala Asp Ala His Tyr Lys Ser Val Gln 
            340                 345                 350         


Thr Trp Asn Glu Ile Ile Pro Ser Lys Gly Cys Leu Arg Val Gly Glu 
        355                 360                 365             


Arg Cys His Pro His Val Asn Gly Val Phe Phe Asn Gly Ile Ile Leu 
    370                 375                 380                 


Gly Ser Asp Gly His Val Leu Ile Pro Glu Met Gln Ser Ser Leu Leu 
385                 390                 395                 400 


Gln Gln His Met Glu Leu Leu Glu Ser Ser Val Ile Pro Leu Met His 
                405                 410                 415     


Pro Leu Ala Asp Pro Ser Thr Val Phe Lys Asp Gly Asp Glu Val Glu 
            420                 425                 430         


Asp Phe Val Glu Val His Leu Pro Asp Val His Lys Gln Val Ser Gly 
        435                 440                 445             


Val Asp Leu Gly Leu Pro Lys Trp Gly Lys Tyr Val Leu Met Ile Ala 
    450                 455                 460                 


Gly Ala Leu Ile Ala Leu Met Leu Ile Ile Phe Leu Met Thr Cys Cys 
465                 470                 475                 480 


Arg Arg Val Asn Arg Pro Glu Ser Thr Gln Ser Asn Leu Gly Gly Thr 
                485                 490                 495     


Gly Arg Asn Val Ser Val Pro Ser Gln Ser Gly Lys Val Ile Ser Ser 
            500                 505                 510         


Trp Glu Ser Tyr Lys Ser Gly Gly Glu Thr Arg Leu 
        515                 520                 


<210>  50
<211>  524
<212>  PRT
<213>  Rabies virus

<400>  50

Met Ile Pro Gln Ala Leu Leu Phe Val Pro Leu Leu Ile Pro Ser Leu 
1               5                   10                  15      


Cys Leu Gly Lys Phe Pro Ile Tyr Thr Ile Pro Asp Lys Leu Gly Pro 
            20                  25                  30          


Trp Ser Pro Ile Asp Ile His His Leu Ser Cys Pro Asn Asn Leu Val 
        35                  40                  45              


Val Glu Asp Glu Gly Cys Thr Ser Leu Ser Gly Phe Ser Tyr Met Glu 
    50                  55                  60                  


Leu Lys Val Gly Tyr Ile Ser Ala Met Lys Val Asn Gly Phe Thr Cys 
65                  70                  75                  80  


Thr Gly Val Val Thr Glu Ala Glu Thr Tyr Thr Asn Phe Val Gly Tyr 
                85                  90                  95      


Val Thr Thr Thr Phe Lys Arg Lys His Phe Arg Pro Met Pro Asp Ala 
            100                 105                 110         


Cys Arg Ala Ala His Asp Trp Lys Ile Ala Gly Asp Pro Arg Tyr Glu 
        115                 120                 125             


Asp Ser Leu Gln Asn Pro Tyr Pro Asp Tyr His Trp Leu Arg Thr Val 
    130                 135                 140                 


Lys Thr Thr Lys Glu Ser Leu Val Ile Ile Ser Pro Ser Val Ala Asp 
145                 150                 155                 160 


Leu Asp Pro Tyr Asp Lys Ser Leu His Ser Arg Val Phe Pro Ser Gly 
                165                 170                 175     


Lys Cys Leu Gly Ile Thr Val Ser Ser Thr Tyr Cys Pro Thr Asn His 
            180                 185                 190         


Asp Tyr Thr Ile Trp Met Pro Val Glu Ala Arg Leu Gly Thr Ser Cys 
        195                 200                 205             


Asp Ile Phe Thr Asn Ser Arg Gly Lys Lys Ala Ser Lys Gly Gly Arg 
    210                 215                 220                 


Thr Cys Gly Phe Val Asp Glu Arg Gly Leu Tyr Lys Ser Leu Lys Gly 
225                 230                 235                 240 


Ala Cys Lys Leu Lys Leu Cys Gly Val Pro Gly Leu Arg Leu Met Asn 
                245                 250                 255     


Gly Thr Trp Val Ser Ile Gln Thr Ser Asp Asp Ile Lys Trp Cys Pro 
            260                 265                 270         


Pro Asp Gln Leu Val Asn Leu His Asp Phe His Ser Asp Glu Ile Glu 
        275                 280                 285             


His Leu Val Val Glu Glu Leu Ile Lys Lys Arg Glu Gly Cys Leu Asp 
    290                 295                 300                 


Ala Leu Glu Ser Ile Met Thr Thr Lys Ser Val Ser Phe Arg Arg Leu 
305                 310                 315                 320 


Ser His Leu Arg Lys Leu Val Pro Gly Phe Gly Lys Ala Tyr Thr Ile 
                325                 330                 335     


Phe Asn Asn Thr Leu Met Glu Ala Asp Ala His Tyr Lys Ser Val Arg 
            340                 345                 350         


Thr Trp Asn Glu Val Ile Pro Ser Lys Gly Cys Leu Lys Val Gly Gly 
        355                 360                 365             


Arg Cys His Pro Pro Val Asn Gly Val Phe Phe Asn Gly Ile Ile Leu 
    370                 375                 380                 


Gly Pro Asp Gly Asn Val Leu Ile Pro Glu Met Gln Ser Ser Leu Leu 
385                 390                 395                 400 


Gln Gln His Met Glu Leu Leu Glu Ser Ser Val Ile Pro Leu Met His 
                405                 410                 415     


Pro Leu Ala Asp Pro Ser Thr Val Phe Lys Asp Gly Asp Glu Ala Glu 
            420                 425                 430         


Asp Phe Val Glu Val His Leu Pro Asp Val His Lys Gln Val Ser Asp 
        435                 440                 445             


Val Asp Leu Gly Leu Pro Ser Trp Gly Lys Tyr Leu Leu Met Ser Ala 
    450                 455                 460                 


Gly Ala Leu Ala Thr Leu Ile Leu Ala Ile Phe Leu Ile Thr Cys Cys 
465                 470                 475                 480 


Arg Arg Ala Asn Arg Thr Lys Ser Thr Gln Arg Gly His Arg Glu Ser 
                485                 490                 495     


Gly Gly Lys Val Ser Val Ala Pro Gln Asn Gly Lys Ile Ile Ser Ser 
            500                 505                 510         


Trp Glu Leu Tyr Lys Ser Glu Ser Glu Thr Gly Met 
        515                 520                 


<210>  51
<211>  904
<212>  PRT
<213>  Herpes simplex virus 2

<400>  51

Met Arg Gly Gly Gly Leu Ile Cys Ala Leu Val Val Gly Ala Leu Val 
1               5                   10                  15      


Ala Ala Val Ala Ser Ala Ala Pro Ala Ala Pro Ala Ala Pro Arg Ala 
            20                  25                  30          


Ser Gly Gly Val Ala Ala Thr Val Ala Ala Asn Gly Gly Pro Ala Ser 
        35                  40                  45              


Arg Pro Pro Pro Val Pro Ser Pro Ala Thr Thr Lys Ala Arg Lys Arg 
    50                  55                  60                  


Lys Thr Lys Lys Pro Pro Lys Arg Pro Glu Ala Thr Pro Pro Pro Asp 
65                  70                  75                  80  


Ala Asn Ala Thr Val Ala Ala Gly His Ala Thr Leu Arg Ala His Leu 
                85                  90                  95      


Arg Glu Ile Lys Val Glu Asn Ala Asp Ala Gln Phe Tyr Val Cys Pro 
            100                 105                 110         


Pro Pro Thr Gly Ala Thr Val Val Gln Phe Glu Gln Pro Arg Arg Cys 
        115                 120                 125             


Pro Thr Arg Pro Glu Gly Gln Asn Tyr Thr Glu Gly Ile Ala Val Val 
    130                 135                 140                 


Phe Lys Glu Asn Ile Ala Pro Tyr Lys Phe Lys Ala Thr Met Tyr Tyr 
145                 150                 155                 160 


Lys Asp Val Thr Val Ser Gln Val Trp Phe Gly His Arg Tyr Ser Gln 
                165                 170                 175     


Phe Met Gly Ile Phe Glu Asp Arg Ala Pro Val Pro Phe Glu Glu Val 
            180                 185                 190         


Ile Asp Lys Ile Asn Ala Lys Gly Val Cys Arg Ser Thr Ala Lys Tyr 
        195                 200                 205             


Val Arg Asn Asn Met Glu Thr Thr Ala Phe His Arg Asp Asp His Glu 
    210                 215                 220                 


Thr Asp Met Glu Leu Lys Pro Ala Lys Val Ala Thr Arg Thr Ser Arg 
225                 230                 235                 240 


Gly Trp His Thr Thr Asp Leu Lys Tyr Asn Pro Ser Arg Val Glu Ala 
                245                 250                 255     


Phe His Arg Tyr Gly Thr Thr Val Asn Cys Ile Val Glu Glu Val Asp 
            260                 265                 270         


Ala Arg Ser Val Tyr Pro Tyr Asp Glu Phe Val Leu Ala Thr Gly Asp 
        275                 280                 285             


Phe Val Tyr Met Ser Pro Phe Tyr Gly Tyr Arg Glu Gly Ser His Thr 
    290                 295                 300                 


Glu His Thr Ser Tyr Ala Ala Asp Arg Phe Lys Gln Val Asp Gly Phe 
305                 310                 315                 320 


Tyr Ala Arg Asp Leu Thr Thr Lys Ala Arg Ala Thr Ser Pro Thr Thr 
                325                 330                 335     


Arg Asn Leu Leu Thr Thr Pro Lys Phe Thr Val Ala Trp Asp Trp Val 
            340                 345                 350         


Pro Lys Arg Pro Ala Val Cys Thr Met Thr Lys Trp Gln Glu Val Asp 
        355                 360                 365             


Glu Met Leu Arg Ala Glu Tyr Gly Gly Ser Phe Arg Phe Ser Ser Asp 
    370                 375                 380                 


Ala Ile Ser Thr Thr Phe Thr Thr Asn Leu Thr Gln Tyr Ser Leu Ser 
385                 390                 395                 400 


Arg Val Asp Leu Gly Asp Cys Ile Gly Arg Asp Ala Arg Glu Ala Ile 
                405                 410                 415     


Asp Arg Met Phe Ala Arg Lys Tyr Asn Ala Thr His Ile Lys Val Gly 
            420                 425                 430         


Gln Pro Gln Tyr Tyr Leu Ala Thr Gly Gly Phe Leu Ile Ala Tyr Gln 
        435                 440                 445             


Pro Leu Leu Ser Asn Thr Leu Ala Glu Leu Tyr Val Arg Glu Tyr Met 
    450                 455                 460                 


Arg Glu Gln Asp Arg Lys Pro Arg Asn Ala Thr Pro Ala Pro Leu Arg 
465                 470                 475                 480 


Glu Ala Pro Ser Ala Asn Ala Ser Val Glu Arg Ile Lys Thr Thr Ser 
                485                 490                 495     


Ser Ile Glu Phe Ala Arg Leu Gln Phe Thr Tyr Asn His Ile Gln Arg 
            500                 505                 510         


His Val Asn Asp Met Leu Gly Arg Ile Ala Val Ala Trp Cys Glu Leu 
        515                 520                 525             


Gln Asn His Glu Leu Thr Leu Trp Asn Glu Ala Arg Lys Leu Asn Pro 
    530                 535                 540                 


Asn Ala Ile Ala Ser Ala Thr Val Gly Arg Arg Val Ser Ala Arg Met 
545                 550                 555                 560 


Leu Gly Asp Val Met Ala Val Ser Thr Cys Val Pro Val Ala Pro Asp 
                565                 570                 575     


Asn Val Ile Val Gln Asn Ser Met Arg Val Ser Ser Arg Pro Gly Thr 
            580                 585                 590         


Cys Tyr Ser Arg Pro Leu Val Ser Phe Arg Tyr Glu Asp Gln Gly Pro 
        595                 600                 605             


Leu Ile Glu Gly Gln Leu Gly Glu Asn Asn Glu Leu Arg Leu Thr Arg 
    610                 615                 620                 


Asp Ala Leu Glu Pro Cys Thr Val Gly His Arg Arg Tyr Phe Ile Phe 
625                 630                 635                 640 


Gly Gly Gly Tyr Val Tyr Phe Glu Glu Tyr Ala Tyr Ser His Gln Leu 
                645                 650                 655     


Ser Arg Ala Asp Val Thr Thr Val Ser Thr Phe Ile Asp Leu Asn Ile 
            660                 665                 670         


Thr Met Leu Glu Asp His Glu Phe Val Pro Leu Glu Val Tyr Thr Arg 
        675                 680                 685             


His Glu Ile Lys Asp Ser Gly Leu Leu Asp Tyr Thr Glu Val Gln Arg 
    690                 695                 700                 


Arg Asn Gln Leu His Asp Leu Arg Phe Ala Asp Ile Asp Thr Val Ile 
705                 710                 715                 720 


Arg Ala Asp Ala Asn Ala Ala Met Phe Ala Gly Leu Cys Ala Phe Phe 
                725                 730                 735     


Glu Gly Met Gly Asp Leu Gly Arg Ala Val Gly Lys Val Val Met Gly 
            740                 745                 750         


Val Val Gly Gly Val Val Ser Ala Val Ser Gly Val Ser Ser Phe Met 
        755                 760                 765             


Ser Asn Pro Phe Gly Ala Leu Ala Val Gly Leu Leu Val Leu Ala Gly 
    770                 775                 780                 


Leu Val Ala Ala Phe Phe Ala Phe Arg Tyr Val Leu Gln Leu Gln Arg 
785                 790                 795                 800 


Asn Pro Met Lys Ala Leu Tyr Pro Leu Thr Thr Lys Glu Leu Lys Thr 
                805                 810                 815     


Ser Asp Pro Gly Gly Val Gly Gly Glu Gly Glu Glu Gly Ala Glu Gly 
            820                 825                 830         


Gly Gly Phe Asp Glu Ala Lys Leu Ala Glu Ala Arg Glu Met Ile Arg 
        835                 840                 845             


Tyr Met Ala Leu Val Ser Ala Met Glu Arg Thr Glu His Lys Ala Arg 
    850                 855                 860                 


Lys Lys Gly Thr Ser Ala Leu Leu Ser Ser Lys Val Thr Asn Met Val 
865                 870                 875                 880 


Leu Arg Lys Arg Asn Lys Ala Arg Tyr Ser Pro Leu His Asn Glu Asp 
                885                 890                 895     


Glu Ala Gly Asp Glu Asp Glu Leu 
            900                 


<210>  52
<211>  393
<212>  PRT
<213>  Herpes simplex virus 2

<400>  52

Met Gly Arg Leu Thr Ser Gly Val Gly Thr Ala Ala Leu Leu Val Val 
1               5                   10                  15      


Ala Val Gly Leu Arg Val Val Cys Ala Lys Tyr Ala Leu Ala Asp Pro 
            20                  25                  30          


Ser Leu Lys Met Ala Asp Pro Asn Arg Phe Arg Gly Lys Asn Leu Pro 
        35                  40                  45              


Val Leu Asp Gln Leu Thr Asp Pro Pro Gly Val Lys Arg Val Tyr His 
    50                  55                  60                  


Ile Gln Pro Ser Leu Glu Asp Pro Phe Gln Pro Pro Ser Ile Pro Ile 
65                  70                  75                  80  


Thr Val Tyr Tyr Ala Val Leu Glu Arg Ala Cys Arg Ser Val Leu Leu 
                85                  90                  95      


His Ala Pro Ser Glu Ala Pro Gln Ile Val Arg Gly Ala Ser Asp Glu 
            100                 105                 110         


Ala Arg Lys His Thr Tyr Asn Leu Thr Ile Ala Trp Tyr Arg Met Gly 
        115                 120                 125             


Asp Asn Cys Ala Ile Pro Ile Thr Val Met Glu Tyr Thr Glu Cys Pro 
    130                 135                 140                 


Tyr Asn Lys Ser Leu Gly Val Cys Pro Ile Arg Thr Gln Pro Arg Trp 
145                 150                 155                 160 


Ser Tyr Tyr Asp Ser Phe Ser Ala Val Ser Glu Asp Asn Leu Gly Phe 
                165                 170                 175     


Leu Met His Ala Pro Ala Phe Glu Thr Ala Gly Thr Tyr Leu Arg Leu 
            180                 185                 190         


Val Lys Ile Asn Asp Trp Thr Glu Ile Thr Gln Phe Ile Leu Glu His 
        195                 200                 205             


Arg Ala Arg Ala Ser Cys Lys Tyr Ala Leu Pro Leu Arg Ile Pro Pro 
    210                 215                 220                 


Ala Ala Cys Leu Thr Ser Lys Ala Tyr Gln Gln Gly Val Thr Val Asp 
225                 230                 235                 240 


Ser Ile Gly Met Leu Pro Arg Phe Thr Pro Glu Asn Gln Arg Thr Val 
                245                 250                 255     


Ala Leu Tyr Ser Leu Lys Ile Ala Gly Trp His Gly Pro Lys Pro Pro 
            260                 265                 270         


Tyr Thr Ser Thr Leu Leu Pro Pro Glu Leu Ser Asp Thr Thr Asn Ala 
        275                 280                 285             


Thr Gln Pro Glu Leu Val Pro Glu Asp Pro Glu Asp Ser Ala Leu Leu 
    290                 295                 300                 


Glu Asp Pro Ala Gly Thr Val Ser Ser Gln Ile Pro Pro Asn Trp His 
305                 310                 315                 320 


Ile Pro Ser Ile Gln Asp Val Ala Pro His His Ala Pro Ala Ala Pro 
                325                 330                 335     


Ala Asn Pro Gly Leu Ile Ile Gly Ala Leu Ala Gly Ser Thr Leu Ala 
            340                 345                 350         


Ala Leu Val Ile Gly Gly Ile Ala Phe Trp Val Arg Arg Arg Arg Ser 
        355                 360                 365             


Val Ala Pro Lys Arg Leu Arg Leu Pro His Ile Arg Asp Asp Asp Ala 
    370                 375                 380                 


Pro Pro Ser His Gln Pro Leu Phe Tyr 
385                 390             


<210>  53
<211>  838
<212>  PRT
<213>  Herpes simplex virus 2

<400>  53

Met Gly Pro Gly Leu Trp Val Val Met Gly Val Leu Val Gly Val Ala 
1               5                   10                  15      


Gly Gly His Asp Thr Tyr Trp Thr Glu Gln Ile Asp Pro Trp Phe Leu 
            20                  25                  30          


His Gly Leu Gly Leu Ala Arg Thr Tyr Trp Arg Asp Thr Asn Thr Gly 
        35                  40                  45              


Arg Leu Trp Leu Pro Asn Thr Pro Asp Ala Ser Asp Pro Gln Arg Gly 
    50                  55                  60                  


Arg Leu Ala Pro Pro Gly Glu Leu Asn Leu Thr Thr Ala Ser Val Pro 
65                  70                  75                  80  


Met Leu Arg Trp Tyr Ala Glu Arg Phe Cys Phe Val Leu Val Thr Thr 
                85                  90                  95      


Ala Glu Phe Pro Arg Asp Pro Gly Gln Leu Leu Tyr Ile Pro Lys Thr 
            100                 105                 110         


Tyr Leu Leu Gly Arg Pro Arg Asn Ala Ser Leu Pro Glu Leu Pro Glu 
        115                 120                 125             


Ala Gly Pro Thr Ser Arg Pro Pro Ala Glu Val Thr Gln Leu Lys Gly 
    130                 135                 140                 


Leu Ser His Asn Pro Gly Ala Ser Ala Leu Leu Arg Ser Arg Ala Trp 
145                 150                 155                 160 


Val Thr Phe Ala Ala Ala Pro Asp Arg Glu Gly Leu Thr Phe Pro Arg 
                165                 170                 175     


Gly Asp Asp Gly Ala Thr Glu Arg His Pro Asp Gly Arg Arg Asn Ala 
            180                 185                 190         


Pro Pro Pro Gly Pro Pro Ala Gly Thr Pro Arg His Pro Thr Thr Asn 
        195                 200                 205             


Leu Ser Ile Ala His Leu His Asn Ala Ser Val Thr Trp Leu Ala Ala 
    210                 215                 220                 


Arg Gly Leu Leu Arg Thr Pro Gly Arg Tyr Val Tyr Leu Ser Pro Ser 
225                 230                 235                 240 


Ala Ser Thr Trp Pro Val Gly Val Trp Thr Thr Gly Gly Leu Ala Phe 
                245                 250                 255     


Gly Cys Asp Ala Ala Leu Val Arg Ala Arg Tyr Gly Lys Gly Phe Met 
            260                 265                 270         


Gly Leu Val Ile Ser Met Arg Asp Ser Pro Pro Ala Glu Ile Ile Val 
        275                 280                 285             


Val Pro Ala Asp Lys Thr Leu Ala Arg Val Gly Asn Pro Thr Asp Glu 
    290                 295                 300                 


Asn Ala Pro Ala Val Leu Pro Gly Pro Pro Ala Gly Pro Arg Tyr Arg 
305                 310                 315                 320 


Val Phe Val Leu Gly Ala Pro Thr Pro Ala Asp Asn Gly Ser Ala Leu 
                325                 330                 335     


Asp Ala Leu Arg Arg Val Ala Gly Tyr Pro Glu Glu Ser Thr Asn Tyr 
            340                 345                 350         


Ala Gln Tyr Met Ser Arg Ala Tyr Ala Glu Phe Leu Gly Glu Asp Pro 
        355                 360                 365             


Gly Ser Gly Thr Asp Ala Arg Pro Ser Leu Phe Trp Arg Leu Ala Gly 
    370                 375                 380                 


Leu Leu Ala Ser Ser Gly Phe Ala Phe Val Asn Ala Ala His Ala His 
385                 390                 395                 400 


Asp Ala Ile Arg Leu Ser Asp Leu Leu Gly Phe Leu Ala His Ser Arg 
                405                 410                 415     


Val Leu Ala Gly Leu Ala Ala Arg Gly Ala Ala Gly Cys Ala Ala Asp 
            420                 425                 430         


Ser Val Phe Leu Asn Val Ser Val Leu Asp Pro Ala Ala Arg Leu Arg 
        435                 440                 445             


Leu Glu Ala Arg Leu Gly His Leu Val Ala Ala Ile Leu Glu Arg Glu 
    450                 455                 460                 


Gln Ser Leu Val Ala His Ala Leu Gly Tyr Gln Leu Ala Phe Val Leu 
465                 470                 475                 480 


Asp Ser Pro Ala Ala Tyr Gly Ala Val Ala Pro Ser Ala Ala Arg Leu 
                485                 490                 495     


Ile Asp Ala Leu Tyr Ala Glu Phe Leu Gly Gly Arg Ala Leu Thr Ala 
            500                 505                 510         


Pro Met Val Arg Arg Ala Leu Phe Tyr Ala Thr Ala Val Leu Arg Ala 
        515                 520                 525             


Pro Phe Leu Ala Gly Ala Pro Ser Ala Glu Gln Arg Glu Arg Ala Arg 
    530                 535                 540                 


Arg Gly Leu Leu Ile Thr Thr Ala Leu Cys Thr Ser Asp Val Ala Ala 
545                 550                 555                 560 


Ala Thr His Ala Asp Leu Arg Ala Ala Leu Ala Arg Thr Asp His Gln 
                565                 570                 575     


Lys Asn Leu Phe Trp Leu Pro Asp His Phe Ser Pro Cys Ala Ala Ser 
            580                 585                 590         


Leu Arg Phe Asp Leu Ala Glu Gly Gly Phe Ile Leu Asp Ala Leu Ala 
        595                 600                 605             


Met Ala Thr Arg Ser Asp Ile Pro Ala Asp Val Met Ala Gln Gln Thr 
    610                 615                 620                 


Arg Gly Val Ala Ser Val Leu Thr Arg Trp Ala His Tyr Asn Ala Leu 
625                 630                 635                 640 


Ile Arg Ala Phe Val Pro Glu Ala Thr His Gln Cys Ser Gly Pro Ser 
                645                 650                 655     


His Asn Ala Glu Pro Arg Ile Leu Val Pro Ile Thr His Asn Ala Ser 
            660                 665                 670         


Tyr Val Val Thr His Thr Pro Leu Pro Arg Gly Ile Gly Tyr Lys Leu 
        675                 680                 685             


Thr Gly Val Asp Val Arg Arg Pro Leu Phe Ile Thr Tyr Leu Thr Ala 
    690                 695                 700                 


Thr Cys Glu Gly His Ala Arg Glu Ile Glu Pro Lys Arg Leu Val Arg 
705                 710                 715                 720 


Thr Glu Asn Arg Arg Asp Leu Gly Leu Val Gly Ala Val Phe Leu Arg 
                725                 730                 735     


Tyr Thr Pro Ala Gly Glu Val Met Ser Val Leu Leu Val Asp Thr Asp 
            740                 745                 750         


Ala Thr Gln Gln Gln Leu Ala Gln Gly Pro Val Ala Gly Thr Pro Asn 
        755                 760                 765             


Val Phe Ser Ser Asp Val Pro Ser Val Ala Leu Leu Leu Phe Pro Asn 
    770                 775                 780                 


Gly Thr Val Ile His Leu Leu Ala Phe Asp Thr Leu Pro Ile Ala Thr 
785                 790                 795                 800 


Ile Ala Pro Gly Phe Leu Ala Ala Ser Ala Leu Gly Val Val Met Ile 
                805                 810                 815     


Thr Ala Ala Leu Ala Gly Ile Leu Arg Val Val Arg Thr Cys Val Pro 
            820                 825                 830         


Phe Leu Trp Arg Arg Glu 
        835             


<210>  54
<211>  224
<212>  PRT
<213>  Herpes simplex virus 2

<400>  54

Met Gly Phe Val Cys Leu Phe Gly Leu Val Val Met Gly Ala Trp Gly 
1               5                   10                  15      


Ala Trp Gly Gly Ser Gln Ala Thr Glu Tyr Val Leu Arg Ser Val Ile 
            20                  25                  30          


Ala Lys Glu Val Gly Asp Ile Leu Arg Val Pro Cys Met Arg Thr Pro 
        35                  40                  45              


Ala Asp Asp Val Ser Trp Arg Tyr Glu Ala Pro Ser Val Ile Asp Tyr 
    50                  55                  60                  


Ala Arg Ile Asp Gly Ile Phe Leu Arg Tyr His Cys Pro Gly Leu Asp 
65                  70                  75                  80  


Thr Phe Leu Trp Asp Arg His Ala Gln Arg Ala Tyr Leu Val Asn Pro 
                85                  90                  95      


Phe Leu Phe Ala Ala Gly Phe Leu Glu Asp Leu Ser His Ser Val Phe 
            100                 105                 110         


Pro Ala Asp Thr Gln Glu Thr Thr Thr Arg Arg Ala Leu Tyr Lys Glu 
        115                 120                 125             


Ile Arg Asp Ala Leu Gly Ser Arg Lys Gln Ala Val Ser His Ala Pro 
    130                 135                 140                 


Val Arg Ala Gly Cys Val Asn Phe Asp Tyr Ser Arg Thr Arg Arg Cys 
145                 150                 155                 160 


Val Gly Arg Arg Asp Leu Arg Pro Ala Asn Thr Thr Ser Thr Trp Glu 
                165                 170                 175     


Pro Pro Val Ser Ser Asp Asp Glu Ala Ser Ser Gln Ser Lys Pro Leu 
            180                 185                 190         


Ala Thr Gln Pro Pro Val Leu Ala Leu Ser Asn Ala Pro Pro Arg Arg 
        195                 200                 205             


Val Ser Pro Thr Arg Gly Arg Arg Arg His Thr Arg Leu Arg Arg Asn 
    210                 215                 220                 


<210>  55
<211>  868
<212>  PRT
<213>  Varicella-zoster virus

<400>  55

Met Phe Val Thr Ala Val Val Ser Val Ser Pro Ser Ser Phe Tyr Glu 
1               5                   10                  15      


Ser Leu Gln Val Glu Pro Thr Gln Ser Glu Asp Ile Thr Arg Ser Ala 
            20                  25                  30          


His Leu Gly Asp Gly Asp Glu Ile Arg Glu Ala Ile His Lys Ser Gln 
        35                  40                  45              


Asp Ala Glu Thr Lys Pro Thr Phe Tyr Val Cys Pro Pro Pro Thr Gly 
    50                  55                  60                  


Ser Thr Ile Val Arg Leu Glu Pro Thr Arg Thr Cys Pro Asp Tyr His 
65                  70                  75                  80  


Leu Gly Lys Asn Phe Thr Glu Gly Ile Ala Val Val Tyr Lys Glu Asn 
                85                  90                  95      


Ile Ala Ala Tyr Lys Phe Lys Ala Thr Val Tyr Tyr Lys Asp Val Ile 
            100                 105                 110         


Val Ser Thr Ala Trp Ala Gly Ser Ser Tyr Thr Gln Ile Thr Asn Arg 
        115                 120                 125             


Tyr Ala Asp Arg Val Pro Ile Pro Val Ser Glu Ile Thr Asp Thr Ile 
    130                 135                 140                 


Asp Lys Phe Gly Lys Cys Ser Ser Lys Ala Thr Tyr Val Arg Asn Asn 
145                 150                 155                 160 


His Lys Val Glu Ala Phe Asn Glu Asp Lys Asn Pro Gln Asp Met Pro 
                165                 170                 175     


Leu Ile Ala Ser Lys Tyr Asn Ser Val Gly Ser Lys Ala Trp His Thr 
            180                 185                 190         


Thr Asn Asp Thr Tyr Met Val Ala Gly Thr Pro Gly Thr Tyr Arg Thr 
        195                 200                 205             


Gly Thr Ser Val Asn Cys Ile Ile Glu Glu Val Glu Ala Arg Ser Ile 
    210                 215                 220                 


Phe Pro Tyr Asp Ser Phe Gly Leu Ser Thr Gly Asp Ile Ile Tyr Met 
225                 230                 235                 240 


Ser Pro Phe Phe Gly Leu Arg Asp Gly Ala Tyr Arg Glu His Ser Asn 
                245                 250                 255     


Tyr Ala Met Asp Arg Phe His Gln Phe Glu Gly Tyr Arg Gln Arg Asp 
            260                 265                 270         


Leu Asp Thr Arg Ala Leu Leu Glu Pro Ala Ala Arg Asn Phe Leu Val 
        275                 280                 285             


Thr Pro His Leu Thr Val Gly Trp Asn Trp Lys Pro Lys Arg Thr Glu 
    290                 295                 300                 


Val Cys Ser Leu Val Lys Trp Arg Glu Val Glu Asp Val Val Arg Asp 
305                 310                 315                 320 


Glu Tyr Ala His Asn Phe Arg Phe Thr Met Lys Thr Leu Ser Thr Thr 
                325                 330                 335     


Phe Ile Ser Glu Thr Asn Glu Phe Asn Leu Asn Gln Ile His Leu Ser 
            340                 345                 350         


Gln Cys Val Lys Glu Glu Ala Arg Ala Ile Ile Asn Arg Ile Tyr Thr 
        355                 360                 365             


Thr Arg Tyr Asn Ser Ser His Val Arg Thr Gly Asp Ile Gln Thr Tyr 
    370                 375                 380                 


Leu Ala Arg Gly Gly Phe Val Val Val Phe Gln Pro Leu Leu Ser Asn 
385                 390                 395                 400 


Ser Leu Ala Arg Leu Tyr Leu Gln Glu Leu Val Arg Glu Asn Thr Asn 
                405                 410                 415     


His Ser Pro Gln Lys His Pro Thr Arg Asn Thr Arg Ser Arg Arg Ser 
            420                 425                 430         


Val Pro Val Glu Leu Arg Ala Asn Arg Thr Ile Thr Thr Thr Ser Ser 
        435                 440                 445             


Val Glu Phe Ala Met Leu Gln Phe Thr Tyr Asp His Ile Gln Glu His 
    450                 455                 460                 


Val Asn Glu Met Leu Ala Arg Ile Ser Ser Ser Trp Cys Gln Leu Gln 
465                 470                 475                 480 


Asn Arg Glu Arg Ala Leu Trp Ser Gly Leu Phe Pro Ile Asn Pro Ser 
                485                 490                 495     


Ala Leu Ala Ser Thr Ile Leu Asp Gln Arg Val Lys Ala Arg Ile Leu 
            500                 505                 510         


Gly Asp Val Ile Ser Val Ser Asn Cys Pro Glu Leu Gly Ser Asp Thr 
        515                 520                 525             


Arg Ile Ile Leu Gln Asn Ser Met Arg Val Ser Gly Ser Thr Thr Arg 
    530                 535                 540                 


Cys Tyr Ser Arg Pro Leu Ile Ser Ile Val Ser Leu Asn Gly Ser Gly 
545                 550                 555                 560 


Thr Val Glu Gly Gln Leu Gly Thr Asp Asn Glu Leu Ile Met Ser Arg 
                565                 570                 575     


Asp Leu Leu Glu Pro Cys Val Ala Asn His Lys Arg Tyr Phe Leu Phe 
            580                 585                 590         


Gly His His Tyr Val Tyr Tyr Glu Asp Tyr Arg Tyr Val Arg Glu Ile 
        595                 600                 605             


Ala Val His Asp Val Gly Met Ile Ser Thr Tyr Val Asp Leu Asn Leu 
    610                 615                 620                 


Thr Leu Leu Lys Asp Arg Glu Phe Met Pro Leu Gln Val Tyr Thr Arg 
625                 630                 635                 640 


Asp Glu Leu Arg Asp Thr Gly Leu Leu Asp Tyr Ser Glu Ile Gln Arg 
                645                 650                 655     


Arg Asn Gln Met His Ser Leu Arg Phe Tyr Asp Ile Asp Lys Val Val 
            660                 665                 670         


Gln Tyr Asp Ser Gly Thr Ala Ile Met Gln Gly Met Ala Gln Phe Phe 
        675                 680                 685             


Gln Gly Leu Gly Thr Ala Gly Gln Ala Val Gly His Val Val Leu Gly 
    690                 695                 700                 


Ala Thr Gly Ala Leu Leu Ser Thr Val His Gly Phe Thr Thr Phe Leu 
705                 710                 715                 720 


Ser Asn Pro Phe Gly Ala Leu Ala Val Gly Leu Leu Val Leu Ala Gly 
                725                 730                 735     


Leu Val Ala Ala Phe Phe Ala Tyr Arg Tyr Val Leu Lys Leu Lys Thr 
            740                 745                 750         


Ser Pro Met Lys Ala Leu Tyr Pro Leu Thr Thr Lys Gly Leu Lys Gln 
        755                 760                 765             


Leu Pro Glu Gly Met Asp Pro Phe Ala Glu Lys Pro Asn Ala Thr Asp 
    770                 775                 780                 


Thr Pro Ile Glu Glu Ile Gly Asp Ser Gln Asn Thr Glu Pro Ser Val 
785                 790                 795                 800 


Asn Ser Gly Phe Asp Pro Asp Lys Phe Arg Glu Ala Gln Glu Met Ile 
                805                 810                 815     


Lys Tyr Met Thr Leu Val Ser Ala Ala Glu Arg Gln Glu Ser Lys Ala 
            820                 825                 830         


Arg Lys Lys Asn Lys Thr Ser Ala Leu Leu Thr Ser Arg Leu Thr Gly 
        835                 840                 845             


Leu Ala Leu Arg Asn Arg Arg Gly Tyr Ser Arg Val Arg Thr Glu Asn 
    850                 855                 860                 


Val Thr Gly Val 
865             


<210>  56
<211>  340
<212>  PRT
<213>  Varicella-zoster virus

<400>  56

Met Gln Ala Leu Gly Ile Lys Thr Glu His Phe Ile Ile Met Cys Leu 
1               5                   10                  15      


Leu Ser Gly His Ala Val Phe Thr Leu Trp Tyr Thr Ala Arg Val Lys 
            20                  25                  30          


Phe Glu His Glu Cys Val Tyr Ala Thr Thr Val Ile Asn Gly Gly Pro 
        35                  40                  45              


Val Val Trp Gly Ser Tyr Asn Asn Ser Leu Ile Tyr Val Thr Phe Val 
    50                  55                  60                  


Asn His Ser Thr Phe Leu Asp Gly Leu Ser Gly Tyr Asp Tyr Ser Cys 
65                  70                  75                  80  


Arg Glu Asn Leu Leu Ser Gly Asp Thr Met Val Lys Thr Ala Ile Ser 
                85                  90                  95      


Thr Pro Leu His Asp Lys Ile Arg Ile Val Leu Gly Thr Arg Asn Cys 
            100                 105                 110         


His Ala Tyr Phe Trp Cys Val Gln Leu Lys Met Ile Phe Phe Ala Trp 
        115                 120                 125             


Phe Val Tyr Gly Met Tyr Leu Gln Phe Arg Arg Ile Arg Arg Met Phe 
    130                 135                 140                 


Gly Pro Phe Arg Ser Ser Cys Glu Leu Ile Ser Pro Thr Ser Tyr Ser 
145                 150                 155                 160 


Leu Asn Tyr Val Thr Arg Val Ile Ser Asn Ile Leu Leu Gly Tyr Pro 
                165                 170                 175     


Tyr Thr Lys Leu Ala Arg Leu Leu Cys Asp Val Ser Met Arg Arg Asp 
            180                 185                 190         


Gly Met Ser Lys Val Phe Asn Ala Asp Pro Ile Ser Phe Leu Tyr Met 
        195                 200                 205             


His Lys Gly Val Thr Leu Leu Met Leu Leu Glu Val Ile Ala His Ile 
    210                 215                 220                 


Ser Ser Gly Cys Ile Val Leu Leu Thr Leu Gly Val Ala Tyr Thr Pro 
225                 230                 235                 240 


Cys Ala Leu Leu Tyr Pro Thr Tyr Ile Arg Ile Leu Ala Trp Val Val 
                245                 250                 255     


Val Cys Thr Leu Ala Ile Val Glu Leu Ile Ser Tyr Val Arg Pro Lys 
            260                 265                 270         


Pro Thr Lys Asp Asn His Leu Asn His Ile Asn Thr Gly Gly Ile Arg 
        275                 280                 285             


Gly Ile Cys Thr Thr Cys Cys Ala Thr Val Met Ser Gly Leu Ala Ile 
    290                 295                 300                 


Lys Cys Phe Tyr Ile Val Ile Phe Ala Ile Ala Val Val Ile Phe Met 
305                 310                 315                 320 


His Tyr Glu Gln Arg Val Gln Val Ser Leu Phe Gly Glu Ser Glu Asn 
                325                 330                 335     


Ser Gln Lys His 
            340 


<210>  57
<211>  841
<212>  PRT
<213>  Varicella-zoster virus

<400>  57

Met Phe Ala Leu Val Leu Ala Val Val Ile Leu Pro Leu Trp Thr Thr 
1               5                   10                  15      


Ala Asn Lys Ser Tyr Val Thr Pro Thr Pro Ala Thr Arg Ser Ile Gly 
            20                  25                  30          


His Met Ser Ala Leu Leu Arg Glu Tyr Ser Asp Arg Asn Met Ser Leu 
        35                  40                  45              


Lys Leu Glu Ala Phe Tyr Pro Thr Gly Phe Asp Glu Glu Leu Ile Lys 
    50                  55                  60                  


Ser Leu His Trp Gly Asn Asp Arg Lys His Val Phe Leu Val Ile Val 
65                  70                  75                  80  


Lys Val Asn Pro Thr Thr His Glu Gly Asp Val Gly Leu Val Ile Phe 
                85                  90                  95      


Pro Lys Tyr Leu Leu Ser Pro Tyr His Phe Lys Ala Glu His Arg Ala 
            100                 105                 110         


Pro Phe Pro Ala Gly Arg Phe Gly Phe Leu Ser His Pro Val Thr Pro 
        115                 120                 125             


Asp Val Ser Phe Phe Asp Ser Ser Phe Ala Pro Tyr Leu Thr Thr Gln 
    130                 135                 140                 


His Leu Val Ala Phe Thr Thr Phe Pro Pro Asn Pro Leu Val Trp His 
145                 150                 155                 160 


Leu Glu Arg Ala Glu Thr Ala Ala Thr Ala Glu Arg Pro Phe Gly Val 
                165                 170                 175     


Ser Leu Leu Pro Ala Arg Pro Thr Val Pro Lys Asn Thr Ile Leu Glu 
            180                 185                 190         


His Lys Ala His Phe Ala Thr Trp Asp Ala Leu Ala Arg His Thr Phe 
        195                 200                 205             


Phe Ser Ala Glu Ala Ile Ile Thr Asn Ser Thr Leu Arg Ile His Val 
    210                 215                 220                 


Pro Leu Phe Gly Ser Val Trp Pro Ile Arg Tyr Trp Ala Thr Gly Ser 
225                 230                 235                 240 


Val Leu Leu Thr Ser Asp Ser Gly Arg Val Glu Val Asn Ile Gly Val 
                245                 250                 255     


Gly Phe Met Ser Ser Leu Ile Ser Leu Ser Ser Gly Pro Pro Ile Glu 
            260                 265                 270         


Leu Ile Val Val Pro His Thr Val Lys Leu Asn Ala Val Thr Ser Asp 
        275                 280                 285             


Thr Thr Trp Phe Gln Leu Asn Pro Pro Gly Pro Asp Pro Gly Pro Ser 
    290                 295                 300                 


Tyr Arg Val Tyr Leu Leu Gly Arg Gly Leu Asp Met Asn Phe Ser Lys 
305                 310                 315                 320 


His Ala Thr Val Asp Ile Cys Ala Tyr Pro Glu Glu Ser Leu Asp Tyr 
                325                 330                 335     


Arg Tyr His Leu Ser Met Ala His Thr Glu Ala Leu Arg Met Thr Thr 
            340                 345                 350         


Lys Ala Asp Gln His Asp Ile Asn Glu Glu Ser Tyr Tyr His Ile Ala 
        355                 360                 365             


Ala Arg Ile Ala Thr Ser Ile Phe Ala Leu Ser Glu Met Gly Arg Thr 
    370                 375                 380                 


Thr Glu Tyr Phe Leu Leu Asp Glu Ile Val Asp Val Gln Tyr Gln Leu 
385                 390                 395                 400 


Lys Phe Leu Asn Tyr Ile Leu Met Arg Ile Gly Ala Gly Ala His Pro 
                405                 410                 415     


Asn Thr Ile Ser Gly Thr Ser Asp Leu Ile Phe Ala Asp Pro Ser Gln 
            420                 425                 430         


Leu His Asp Glu Leu Ser Leu Leu Phe Gly Gln Val Lys Pro Ala Asn 
        435                 440                 445             


Val Asp Tyr Phe Ile Ser Tyr Asp Glu Ala Arg Asp Gln Leu Lys Thr 
    450                 455                 460                 


Ala Tyr Ala Leu Ser Arg Gly Gln Asp His Val Asn Ala Leu Ser Leu 
465                 470                 475                 480 


Ala Arg Arg Val Ile Met Ser Ile Tyr Lys Gly Leu Leu Val Lys Gln 
                485                 490                 495     


Asn Leu Asn Ala Thr Glu Arg Gln Ala Leu Phe Phe Ala Ser Met Ile 
            500                 505                 510         


Leu Leu Asn Phe Arg Glu Gly Leu Glu Asn Ser Ser Arg Val Leu Asp 
        515                 520                 525             


Gly Arg Thr Thr Leu Leu Leu Met Thr Ser Met Cys Thr Ala Ala His 
    530                 535                 540                 


Ala Thr Gln Ala Ala Leu Asn Ile Gln Glu Gly Leu Ala Tyr Leu Asn 
545                 550                 555                 560 


Pro Ser Lys His Met Phe Thr Ile Pro Asn Val Tyr Ser Pro Cys Met 
                565                 570                 575     


Gly Ser Leu Arg Thr Asp Leu Thr Glu Glu Ile His Val Met Asn Leu 
            580                 585                 590         


Leu Ser Ala Ile Pro Thr Arg Pro Gly Leu Asn Glu Val Leu His Thr 
        595                 600                 605             


Gln Leu Asp Glu Ser Glu Ile Phe Asp Ala Ala Phe Lys Thr Met Met 
    610                 615                 620                 


Ile Phe Thr Thr Trp Thr Ala Lys Asp Leu His Ile Leu His Thr His 
625                 630                 635                 640 


Val Pro Glu Val Phe Thr Cys Gln Asp Ala Ala Ala Arg Asn Gly Glu 
                645                 650                 655     


Tyr Val Leu Ile Leu Pro Ala Val Gln Gly His Ser Tyr Val Ile Thr 
            660                 665                 670         


Arg Asn Lys Pro Gln Arg Gly Leu Val Tyr Ser Leu Ala Asp Val Asp 
        675                 680                 685             


Val Tyr Asn Pro Ile Ser Val Val Tyr Leu Ser Arg Asp Thr Cys Val 
    690                 695                 700                 


Ser Glu His Gly Val Ile Glu Thr Val Ala Leu Pro His Pro Asp Asn 
705                 710                 715                 720 


Leu Lys Glu Cys Leu Tyr Cys Gly Ser Val Phe Leu Arg Tyr Leu Thr 
                725                 730                 735     


Thr Gly Ala Ile Met Asp Ile Ile Ile Ile Asp Ser Lys Asp Thr Glu 
            740                 745                 750         


Arg Gln Leu Ala Ala Met Gly Asn Ser Thr Ile Pro Pro Phe Asn Pro 
        755                 760                 765             


Asp Met His Gly Asp Asp Ser Lys Ala Val Leu Leu Phe Pro Asn Gly 
    770                 775                 780                 


Thr Val Val Thr Leu Leu Gly Phe Glu Arg Arg Gln Ala Ile Arg Met 
785                 790                 795                 800 


Ser Gly Gln Tyr Leu Gly Ala Ser Leu Gly Gly Ala Phe Leu Ala Val 
                805                 810                 815     


Val Gly Phe Gly Ile Ile Gly Trp Met Leu Cys Gly Asn Ser Arg Leu 
            820                 825                 830         


Arg Glu Tyr Asn Lys Ile Pro Leu Thr 
        835                 840     


<210>  58
<211>  160
<212>  PRT
<213>  Varicella-zoster virus

<400>  58

Met Ala Ser His Lys Trp Leu Leu Gln Met Ile Val Phe Leu Lys Thr 
1               5                   10                  15      


Ile Thr Ile Ala Tyr Cys Leu His Leu Gln Asp Asp Thr Pro Leu Phe 
            20                  25                  30          


Phe Gly Ala Lys Pro Leu Ser Asp Val Ser Leu Ile Ile Thr Glu Pro 
        35                  40                  45              


Cys Val Ser Ser Val Tyr Glu Ala Trp Asp Tyr Ala Ala Pro Pro Val 
    50                  55                  60                  


Ser Asn Leu Ser Glu Ala Leu Ser Gly Ile Val Val Lys Thr Lys Cys 
65                  70                  75                  80  


Pro Val Pro Glu Val Ile Leu Trp Phe Lys Asp Lys Gln Met Ala Tyr 
                85                  90                  95      


Trp Thr Asn Pro Tyr Val Thr Leu Lys Gly Leu Thr Gln Ser Val Gly 
            100                 105                 110         


Glu Glu His Lys Ser Gly Asp Ile Arg Asp Ala Leu Leu Asp Ala Leu 
        115                 120                 125             


Ser Gly Val Trp Val Asp Ser Thr Pro Ser Ser Thr Asn Ile Pro Glu 
    130                 135                 140                 


Asn Gly Cys Val Trp Gly Ala Asp Arg Leu Phe Gln Arg Val Cys Gln 
145                 150                 155                 160 


<210>  59
<211>  445
<212>  PRT
<213>  Hepatitis B virus

<400>  59

Met Gln Leu Ile Ile Thr Ser Lys Leu Gly Ile Ile Tyr Ile Leu Cys 
1               5                   10                  15      


Gly Arg Leu Ala Phe Tyr Ile Arg Glu Lys Leu His Ala Val Pro His 
            20                  25                  30          


Phe Val Gly His His Ile Leu Gly Asn Lys Ser Tyr Ser Met Gly Gly 
        35                  40                  45              


Trp Ser Ser Lys Pro Arg Gln Gly Met Gly Thr Asn Leu Ser Val Pro 
    50                  55                  60                  


Asn Pro Leu Gly Phe Phe Pro Asp His Gln Leu Asp Pro Ala Phe Gly 
65                  70                  75                  80  


Ala Asn Ser Asn Asn Pro Asp Trp Asp Phe Asn Pro Asn Lys Asp His 
                85                  90                  95      


Trp Pro Glu Ala Lys Gln Val Gly Ala Gly Ala Phe Gly Pro Gly Phe 
            100                 105                 110         


Thr Pro Pro His Gly Gly Leu Leu Gly Trp Ser Pro Gln Ala Gln Gly 
        115                 120                 125             


Thr Leu Thr Thr Val Pro Ala Ala Pro Pro Pro Ala Ser Thr Asn Arg 
    130                 135                 140                 


Gln Ser Gly Arg Gln Pro Thr Pro Ile Ser Pro Pro Leu Arg Asp Ser 
145                 150                 155                 160 


His Pro Gln Ala Met Gln Trp Asn Ser Thr Thr Phe His Gln Ala Leu 
                165                 170                 175     


Leu Asp Pro Arg Val Arg Gly Leu Tyr Phe Pro Ala Gly Gly Ser Ser 
            180                 185                 190         


Ser Gly Thr Val Asn Pro Val Pro Thr Thr Ala Ser Pro Ile Ser Ser 
        195                 200                 205             


Ile Phe Ser Arg Thr Gly Asp Pro Ala Pro Asn Met Glu Ser Thr Thr 
    210                 215                 220                 


Ser Gly Phe Leu Gly Pro Leu Leu Val Leu Gln Ala Gly Phe Phe Leu 
225                 230                 235                 240 


Leu Thr Arg Ile Leu Thr Ile Pro Gln Ser Leu Asp Ser Trp Leu Thr 
                245                 250                 255     


Ser Leu Asn Phe Leu Gly Gly Thr Pro Lys Cys Pro Gly Gln Asn Ser 
            260                 265                 270         


Gln Ser Pro Thr Ser Asn His Ser Pro Thr Ser Cys Pro Pro Thr Cys 
        275                 280                 285             


Pro Gly Tyr Arg Trp Met Cys Leu Arg Arg Phe Ile Ile Phe Leu Phe 
    290                 295                 300                 


Ile Leu Leu Leu Cys Leu Ile Phe Leu Leu Val Leu Leu Asp Tyr Lys 
305                 310                 315                 320 


Gly Met Leu Pro Val Cys Pro Leu Leu Pro Gly Thr Ser Thr Thr Ser 
                325                 330                 335     


Thr Gly Pro Cys Lys Thr Cys Thr Ile Pro Ala Gln Asn Thr Ser Met 
            340                 345                 350         


Phe Pro Ser Cys Cys Cys Thr Lys Pro Ser Asp Gly Asn Cys Thr Cys 
        355                 360                 365             


Ile Pro Ile Pro Ser Ser Trp Ala Phe Ala Arg Phe Leu Trp Glu Trp 
    370                 375                 380                 


Ala Ser Val Arg Phe Ser Trp Leu Ser Leu Leu Val Pro Phe Val Gln 
385                 390                 395                 400 


Trp Ser Ala Gly Leu Ser Pro Thr Val Trp Leu Ser Val Ile Trp Thr 
                405                 410                 415     


Met Trp Tyr Trp Gly Pro Ser Leu Tyr Asn Ile Leu Ser Pro Phe Leu 
            420                 425                 430         


Pro Leu Leu Pro Ile Leu Cys Cys Leu Trp Ala Tyr Ile 
        435                 440                 445 


<210>  60
<211>  281
<212>  PRT
<213>  Hepatitis B virus

<400>  60

Met Gln Trp Asn Ser Thr Thr Phe His Gln Ala Leu Gln Asp Pro Arg 
1               5                   10                  15      


Val Arg Gly Leu Tyr Phe Pro Ala Gly Gly Ser Ser Ser Gly Thr Val 
            20                  25                  30          


Asn Pro Val Pro Thr Thr Ala Ser Leu Ile Ser Ser Ile Phe Ser Arg 
        35                  40                  45              


Ile Gly Asp Pro Ala Pro Asn Met Glu Ser Ile Thr Ser Gly Phe Leu 
    50                  55                  60                  


Gly Pro Leu Leu Val Leu Gln Ala Gly Phe Phe Leu Leu Thr Lys Ile 
65                  70                  75                  80  


Leu Thr Ile Pro Gln Ser Leu Asp Ser Trp Trp Thr Ser Leu Asn Phe 
                85                  90                  95      


Leu Gly Gly Ala Pro Val Cys Leu Gly Gln Asn Ser Gln Ser Pro Thr 
            100                 105                 110         


Ser Asn His Ser Pro Thr Ser Cys Pro Pro Ile Cys Pro Gly Tyr Arg 
        115                 120                 125             


Trp Met Cys Leu Arg Arg Phe Ile Ile Phe Leu Phe Ile Leu Leu Leu 
    130                 135                 140                 


Cys Leu Ile Phe Leu Leu Val Leu Leu Asp Tyr Gln Gly Met Leu Pro 
145                 150                 155                 160 


Val Cys Pro Leu Ile Pro Gly Ser Ser Thr Thr Ser Thr Gly Pro Cys 
                165                 170                 175     


Arg Thr Cys Met Thr Leu Ala Gln Gly Thr Ser Met Phe Pro Ser Cys 
            180                 185                 190         


Cys Cys Ser Lys Pro Ser Asp Gly Asn Cys Thr Cys Ile Pro Ile Pro 
        195                 200                 205             


Ser Ser Trp Ala Phe Gly Lys Phe Leu Trp Glu Trp Ala Ser Ala Arg 
    210                 215                 220                 


Phe Ser Trp Leu Ser Leu Leu Val Pro Phe Val Gln Trp Phe Ala Gly 
225                 230                 235                 240 


Leu Ser Pro Thr Val Trp Leu Ser Val Ile Trp Met Met Trp Tyr Trp 
                245                 250                 255     


Gly Pro Ser Leu Tyr Asp Ile Leu Ser Pro Phe Ile Pro Leu Leu Pro 
            260                 265                 270         


Ile Phe Phe Cys Leu Trp Val Tyr Ile 
        275                 280     


<210>  61
<211>  226
<212>  PRT
<213>  Hepatitis B virus

<400>  61

Met Glu Ser Ile Thr Ser Gly Phe Leu Gly Pro Leu Leu Val Leu Gln 
1               5                   10                  15      


Ala Gly Phe Phe Leu Leu Thr Lys Ile Leu Thr Ile Pro Gln Ser Leu 
            20                  25                  30          


Asp Ser Trp Trp Thr Ser Leu Asn Phe Leu Gly Gly Ala Pro Val Cys 
        35                  40                  45              


Leu Gly Gln Asn Ser Gln Ser Pro Thr Ser Asn His Ser Pro Thr Ser 
    50                  55                  60                  


Cys Pro Pro Ile Cys Pro Gly Tyr Arg Trp Met Cys Leu Arg Arg Phe 
65                  70                  75                  80  


Ile Ile Phe Leu Phe Ile Leu Leu Leu Cys Leu Ile Phe Leu Leu Val 
                85                  90                  95      


Leu Leu Asp Tyr Gln Gly Met Leu Pro Val Cys Pro Leu Ile Pro Gly 
            100                 105                 110         


Ser Ser Thr Thr Ser Thr Gly Pro Cys Arg Thr Cys Met Thr Leu Ala 
        115                 120                 125             


Gln Gly Thr Ser Met Phe Pro Ser Cys Cys Cys Ser Lys Pro Ser Asp 
    130                 135                 140                 


Gly Asn Cys Thr Cys Ile Pro Ile Pro Ser Ser Trp Ala Phe Gly Lys 
145                 150                 155                 160 


Phe Leu Trp Glu Trp Ala Ser Ala Arg Phe Ser Trp Leu Ser Leu Leu 
                165                 170                 175     


Val Pro Phe Val Gln Trp Phe Ala Gly Leu Ser Pro Thr Val Trp Leu 
            180                 185                 190         


Ser Val Ile Trp Met Met Trp Tyr Trp Gly Pro Ser Leu Tyr Asp Ile 
        195                 200                 205             


Leu Ser Pro Phe Ile Pro Leu Leu Pro Ile Phe Phe Cys Leu Trp Val 
    210                 215                 220                 


Tyr Ile 
225     


<210>  62
<211>  982
<212>  PRT
<213>  Eastern equine encephalitis virus (EEEV)

<400>  62

Met Ser Leu Ala Thr Val Met Cys Val Leu Ala Asn Ile Thr Phe Pro 
1               5                   10                  15      


Cys Asp Gln Pro Pro Cys Met Pro Cys Cys Tyr Glu Lys Asn Pro His 
            20                  25                  30          


Glu Thr Leu Thr Met Leu Glu Gln Asn Tyr Asp Ser Arg Ala Tyr Asp 
        35                  40                  45              


Gln Leu Leu Asp Ala Ala Val Lys Cys Asn Ala Arg Arg Thr Arg Arg 
    50                  55                  60                  


Asp Leu Asp Thr His Phe Thr Gln Tyr Lys Leu Ala Arg Pro Tyr Ile 
65                  70                  75                  80  


Ala Asp Cys Pro Asn Cys Gly His Ser Arg Cys Asp Ser Pro Ile Ala 
                85                  90                  95      


Ile Glu Glu Val Arg Gly Asp Ala His Ala Gly Val Ile Arg Ile Gln 
            100                 105                 110         


Thr Ser Ala Met Phe Gly Leu Lys Thr Asp Gly Val Asp Leu Ala Tyr 
        115                 120                 125             


Met Ser Phe Met Asn Gly Lys Thr Gln Lys Ser Ile Lys Ile Asp Asn 
    130                 135                 140                 


Leu His Val Arg Thr Ser Ala Pro Cys Ser Leu Val Ser His His Gly 
145                 150                 155                 160 


Tyr Tyr Ile Leu Ala Gln Cys Pro Pro Gly Asp Thr Val Thr Val Gly 
                165                 170                 175     


Phe His Asp Gly Pro Asn Arg His Thr Cys Thr Val Ala His Lys Val 
            180                 185                 190         


Glu Phe Arg Pro Val Gly Arg Glu Lys Tyr Arg His Pro Pro Glu His 
        195                 200                 205             


Gly Val Glu Leu Pro Cys Asn Arg Tyr Thr His Lys Arg Ala Asp Gln 
    210                 215                 220                 


Gly His Tyr Val Glu Met His Gln Pro Gly Leu Val Ala Asp His Ser 
225                 230                 235                 240 


Leu Leu Ser Ile His Ser Ala Lys Val Lys Ile Thr Val Pro Ser Gly 
                245                 250                 255     


Ala Gln Val Lys Tyr Tyr Cys Lys Cys Pro Asp Val Arg Glu Gly Ile 
            260                 265                 270         


Thr Ser Ser Asp His Thr Thr Thr Cys Thr Asp Val Lys Gln Cys Arg 
        275                 280                 285             


Ala Tyr Leu Ile Asp Asn Lys Lys Trp Val Tyr Asn Ser Gly Arg Leu 
    290                 295                 300                 


Pro Arg Gly Glu Gly Asp Thr Phe Lys Gly Lys Leu His Val Pro Phe 
305                 310                 315                 320 


Val Pro Val Lys Ala Lys Cys Ile Ala Thr Leu Ala Pro Glu Pro Leu 
                325                 330                 335     


Val Glu His Lys His Arg Thr Leu Ile Leu His Leu His Pro Asp His 
            340                 345                 350         


Pro Thr Leu Leu Thr Thr Arg Ser Leu Gly Ser Asp Ala Asn Pro Thr 
        355                 360                 365             


Arg Gln Trp Ile Glu Arg Pro Thr Thr Val Asn Phe Thr Val Thr Gly 
    370                 375                 380                 


Glu Gly Leu Glu Tyr Thr Trp Gly Asn His Pro Pro Lys Arg Val Trp 
385                 390                 395                 400 


Ala Gln Glu Ser Gly Glu Gly Asn Pro His Gly Trp Pro His Glu Val 
                405                 410                 415     


Val Val Tyr Tyr Tyr Asn Arg Tyr Pro Leu Thr Thr Ile Ile Gly Leu 
            420                 425                 430         


Cys Thr Cys Val Ala Ile Ile Met Val Ser Cys Val Thr Ser Val Trp 
        435                 440                 445             


Leu Leu Cys Arg Thr Arg Asn Leu Cys Ile Thr Pro Tyr Lys Leu Ala 
    450                 455                 460                 


Pro Asn Ala Gln Val Pro Ile Leu Leu Ala Leu Leu Cys Cys Ile Lys 
465                 470                 475                 480 


Pro Thr Arg Ala Asp Asp Thr Leu Gln Val Leu Asn Tyr Leu Trp Asn 
                485                 490                 495     


Asn Asn Gln Asn Phe Phe Trp Met Gln Thr Leu Ile Pro Leu Ala Ala 
            500                 505                 510         


Leu Ile Val Cys Met Arg Met Leu Arg Cys Leu Phe Cys Cys Gly Pro 
        515                 520                 525             


Ala Phe Leu Leu Val Cys Gly Ala Leu Gly Ala Ala Ala Tyr Glu His 
    530                 535                 540                 


Thr Ala Val Met Pro Asn Lys Val Gly Ile Pro Tyr Lys Ala Leu Val 
545                 550                 555                 560 


Glu Arg Pro Gly Tyr Ala Pro Val His Leu Gln Ile Gln Leu Val Asn 
                565                 570                 575     


Thr Arg Ile Ile Pro Ser Thr Asn Leu Glu Tyr Ile Thr Cys Lys Tyr 
            580                 585                 590         


Lys Thr Lys Val Pro Ser Pro Val Val Lys Cys Cys Gly Ala Thr Gln 
        595                 600                 605             


Cys Thr Ser Lys Pro His Pro Asp Tyr Gln Cys Gln Val Phe Thr Gly 
    610                 615                 620                 


Val Tyr Pro Phe Met Trp Gly Gly Ala Tyr Cys Phe Cys Asp Thr Glu 
625                 630                 635                 640 


Asn Thr Gln Met Ser Glu Ala Tyr Val Glu Arg Ser Glu Glu Cys Ser 
                645                 650                 655     


Ile Asp His Ala Lys Ala Tyr Lys Val His Thr Gly Thr Val Gln Ala 
            660                 665                 670         


Met Val Asn Ile Thr Tyr Gly Ser Val Ser Trp Arg Ser Ala Asp Val 
        675                 680                 685             


Tyr Val Asn Gly Glu Thr Pro Ala Lys Ile Gly Asp Ala Lys Leu Ile 
    690                 695                 700                 


Ile Gly Pro Leu Ser Ser Ala Trp Ser Pro Phe Asp Asn Lys Val Val 
705                 710                 715                 720 


Val Tyr Gly His Glu Val Tyr Asn Tyr Asp Phe Pro Glu Tyr Ser Thr 
                725                 730                 735     


Gly Lys Ala Gly Ser Phe Gly Asp Leu Gln Ser Arg Thr Ser Thr Ser 
            740                 745                 750         


Asn Asp Leu Tyr Ala Asn Thr Asn Leu Lys Leu Gln Arg Pro Gln Ala 
        755                 760                 765             


Gly Ile Val His Thr Pro Phe Thr Gln Ala Pro Ser Gly Phe Glu Arg 
    770                 775                 780                 


Trp Lys Arg Asp Lys Gly Ala Pro Leu Asn Asp Val Ala Pro Phe Gly 
785                 790                 795                 800 


Cys Ser Ile Ala Leu Glu Pro Leu Arg Ala Glu Asn Cys Ala Val Gly 
                805                 810                 815     


Ser Ile Pro Ile Ser Ile Asp Ile Pro Asp Ala Ala Phe Thr Arg Ile 
            820                 825                 830         


Ser Glu Thr Pro Thr Val Ser Asp Leu Glu Cys Lys Ile Thr Glu Cys 
        835                 840                 845             


Thr Tyr Ala Ser Asp Phe Gly Gly Ile Ala Thr Val Ala Tyr Lys Ser 
    850                 855                 860                 


Ser Lys Ala Gly Asn Cys Pro Ile His Ser Pro Ser Gly Val Ala Val 
865                 870                 875                 880 


Ile Lys Glu Asn Asp Val Thr Leu Ala Glu Ser Gly Ser Phe Thr Phe 
                885                 890                 895     


His Phe Ser Thr Ala Asn Ile His Pro Ala Phe Lys Leu Gln Val Cys 
            900                 905                 910         


Thr Ser Ala Val Thr Cys Lys Gly Asp Cys Lys Pro Pro Lys Asp His 
        915                 920                 925             


Ile Val Asp Tyr Pro Ala Gln His Thr Glu Ser Phe Thr Ser Ala Ile 
    930                 935                 940                 


Ser Ala Thr Ala Trp Ser Trp Leu Lys Val Leu Val Gly Gly Thr Ser 
945                 950                 955                 960 


Ala Phe Ile Val Leu Gly Leu Ile Ala Thr Ala Val Val Ala Leu Val 
                965                 970                 975     


Leu Phe Phe His Arg His 
            980         


<210>  63
<211>  981
<212>  PRT
<213>  Venezuelan equine encephalitis viruses (VEEV)

<400>  63

Met Ser Leu Val Thr Thr Met Cys Leu Leu Ala Asn Val Thr Phe Pro 
1               5                   10                  15      


Cys Ala Glu Pro Pro Ile Cys Tyr Asp Arg Lys Pro Ala Glu Thr Leu 
            20                  25                  30          


Ala Met Leu Ser Val Asn Val Asp Asn Pro Gly Tyr Asp Glu Leu Leu 
        35                  40                  45              


Glu Ala Ala Val Lys Cys Pro Gly Arg Lys Arg Arg Ser Thr Lys Glu 
    50                  55                  60                  


Leu Phe Lys Glu Tyr Lys Leu Thr Arg Pro Tyr Met Ala Arg Cys Ile 
65                  70                  75                  80  


Arg Cys Ala Val Gly Ser Cys His Ser Pro Ile Ala Ile Glu Ala Val 
                85                  90                  95      


Lys Ser Asp Gly His Asp Gly Tyr Val Arg Leu Gln Thr Ser Ser Gln 
            100                 105                 110         


Tyr Gly Leu Asp Ser Ser Gly Asn Leu Lys Gly Arg Thr Met Arg Tyr 
        115                 120                 125             


Asp Met His Gly Thr Ile Glu Glu Ile Pro Leu His Gln Val Ser Leu 
    130                 135                 140                 


His Thr Ser Arg Pro Cys His Ile Val Asp Gly His Gly Tyr Phe Leu 
145                 150                 155                 160 


Leu Ala Arg Cys Pro Ala Gly Asp Ser Ile Thr Met Glu Phe Lys Lys 
                165                 170                 175     


Gly Ser Val Thr His Ser Cys Ser Val Pro Tyr Glu Val Lys Phe Asn 
            180                 185                 190         


Pro Val Gly Arg Glu Leu Tyr Thr His Pro Pro Glu His Gly Ala Glu 
        195                 200                 205             


Gln Ala Cys Gln Val Tyr Ala His Asp Ala Gln Asn Arg Gly Ala Tyr 
    210                 215                 220                 


Val Glu Met His Leu Pro Gly Ser Glu Val Asp Ser Ser Leu Ile Ser 
225                 230                 235                 240 


Leu Ser Gly Ser Ser Val Thr Val Thr Pro Pro Val Gly Thr Ser Ala 
                245                 250                 255     


Leu Val Glu Cys Lys Cys Gly Gly Thr Lys Ile Ser Glu Thr Ile Asn 
            260                 265                 270         


Lys Ala Lys Gln Phe Ser Gln Cys Thr Lys Lys Glu Gln Cys Arg Ala 
        275                 280                 285             


Tyr Arg Leu Gln Asn Asp Lys Trp Val Tyr Asn Ser Asp Lys Leu Pro 
    290                 295                 300                 


Lys Ala Ala Gly Ala Thr Leu Lys Gly Lys Leu His Val Pro Phe Leu 
305                 310                 315                 320 


Leu Ala Asp Gly Lys Cys Thr Val Pro Leu Ala Pro Glu Pro Met Ile 
                325                 330                 335     


Thr Phe Gly Phe Arg Ser Val Ser Leu Lys Leu His Pro Lys Asn Pro 
            340                 345                 350         


Thr Tyr Leu Thr Thr Arg Gln Leu Ala Asp Glu Pro His Tyr Thr His 
        355                 360                 365             


Glu Leu Ile Ser Glu Pro Ala Val Arg Asn Phe Thr Val Thr Glu Lys 
    370                 375                 380                 


Gly Trp Glu Phe Val Trp Gly Asn His Pro Pro Lys Arg Phe Trp Ala 
385                 390                 395                 400 


Gln Glu Thr Ala Pro Gly Asn Pro His Gly Leu Pro His Glu Val Ile 
                405                 410                 415     


Thr His Tyr Tyr His Arg Tyr Pro Met Ser Thr Ile Leu Gly Leu Ser 
            420                 425                 430         


Ile Cys Ala Ala Ile Val Thr Val Ser Val Ala Ala Ser Thr Trp Leu 
        435                 440                 445             


Phe Cys Lys Ser Arg Val Ser Cys Leu Thr Pro Tyr Arg Leu Thr Pro 
    450                 455                 460                 


Asn Ala Arg Met Pro Leu Cys Leu Ala Val Leu Cys Cys Ala Arg Thr 
465                 470                 475                 480 


Ala Arg Ala Glu Thr Thr Trp Glu Ser Leu Asp His Leu Trp Asn Asn 
                485                 490                 495     


Asn Gln Gln Met Phe Trp Ile Gln Leu Leu Ile Pro Leu Ala Ala Leu 
            500                 505                 510         


Ile Val Val Thr Arg Leu Leu Lys Cys Val Cys Cys Val Val Pro Phe 
        515                 520                 525             


Leu Val Val Ala Gly Ala Ala Gly Ala Gly Ala Tyr Glu His Ala Thr 
    530                 535                 540                 


Thr Met Pro Ser Gln Ala Gly Ile Ser Tyr Asn Thr Ile Val Asn Arg 
545                 550                 555                 560 


Ala Gly Tyr Ala Pro Leu Pro Ile Ser Ile Thr Pro Thr Lys Ile Lys 
                565                 570                 575     


Leu Ile Pro Thr Val Asn Leu Glu Tyr Val Thr Cys His Tyr Lys Thr 
            580                 585                 590         


Gly Met Asp Ser Pro Ala Ile Lys Cys Cys Gly Ser Gln Glu Cys Thr 
        595                 600                 605             


Pro Thr Asn Arg Pro Asp Glu Gln Cys Lys Val Phe Thr Gly Val Tyr 
    610                 615                 620                 


Pro Phe Met Trp Gly Gly Ala Tyr Cys Phe Cys Asp Thr Glu Asn Thr 
625                 630                 635                 640 


Gln Val Ser Lys Ala Tyr Val Met Lys Ser Asp Asp Cys Leu Ala Asp 
                645                 650                 655     


His Ala Glu Ala Tyr Lys Ala His Thr Ala Ser Val Gln Ala Phe Leu 
            660                 665                 670         


Asn Ile Thr Val Gly Glu His Ser Ile Val Thr Thr Val Tyr Val Asn 
        675                 680                 685             


Gly Glu Thr Pro Val Asn Phe Asn Gly Val Lys Leu Thr Ala Gly Pro 
    690                 695                 700                 


Leu Ser Thr Ala Trp Thr Pro Phe Asp Arg Lys Ile Val Gln Tyr Ala 
705                 710                 715                 720 


Gly Glu Ile Tyr Asn Tyr Asp Phe Pro Glu Tyr Gly Ala Gly Gln Pro 
                725                 730                 735     


Gly Ala Phe Gly Asp Ile Gln Ser Arg Thr Val Ser Ser Ser Asp Leu 
            740                 745                 750         


Tyr Ala Asn Thr Asn Leu Val Leu Gln Arg Pro Lys Ala Gly Ala Ile 
        755                 760                 765             


His Val Pro Tyr Thr Gln Ala Pro Ser Gly Phe Glu Gln Trp Lys Lys 
    770                 775                 780                 


Asp Lys Ala Pro Ser Leu Lys Phe Thr Ala Pro Phe Gly Cys Glu Ile 
785                 790                 795                 800 


Tyr Thr Asn Pro Ile Arg Ala Glu Asn Cys Ala Val Gly Ser Ile Pro 
                805                 810                 815     


Leu Ala Phe Asp Ile Pro Asp Ala Leu Phe Thr Arg Val Ser Glu Thr 
            820                 825                 830         


Pro Thr Leu Ser Ala Ala Glu Cys Thr Leu Asn Glu Cys Val Tyr Ser 
        835                 840                 845             


Ser Asp Phe Gly Gly Ile Ala Thr Val Lys Tyr Ser Ala Ser Lys Ser 
    850                 855                 860                 


Gly Lys Cys Ala Val His Val Pro Ser Gly Thr Ala Thr Leu Lys Glu 
865                 870                 875                 880 


Ala Ala Val Glu Leu Thr Glu Gln Gly Ser Ala Thr Ile His Phe Ser 
                885                 890                 895     


Thr Ala Asn Ile His Pro Glu Phe Arg Leu Gln Ile Cys Thr Ser Tyr 
            900                 905                 910         


Val Thr Cys Lys Gly Asp Cys His Pro Pro Lys Asp His Ile Val Thr 
        915                 920                 925             


His Pro Gln Tyr His Ala Gln Thr Phe Thr Ala Ala Val Ser Lys Thr 
    930                 935                 940                 


Ala Trp Thr Trp Leu Thr Ser Leu Leu Gly Gly Ser Ala Val Ile Ile 
945                 950                 955                 960 


Ile Ile Gly Leu Val Leu Ala Thr Ile Val Ala Met Tyr Val Leu Thr 
                965                 970                 975     


Asn Gln Lys His Asn 
            980     


<210>  64
<211>  978
<212>  PRT
<213>  Western equine encephalitis virus (WEEV)

<400>  64

Met Ser Leu Val Thr Ala Leu Cys Val Leu Ser Asn Val Thr Phe Pro 
1               5                   10                  15      


Cys Asp Lys Pro Pro Val Cys Tyr Ser Leu Ala Pro Glu Arg Thr Leu 
            20                  25                  30          


Asp Val Leu Glu Glu Asn Val Asn Asn Pro Asn Tyr Asp Thr Leu Leu 
        35                  40                  45              


Glu Asn Val Leu Lys Cys Pro Ser Arg Arg Pro Lys Arg Ser Ile Thr 
    50                  55                  60                  


Asp Asp Phe Thr Leu Thr Ser Pro Tyr Leu Gly Phe Cys Pro Tyr Cys 
65                  70                  75                  80  


Arg His Ser Ala Pro Cys Phe Ser Pro Ile Lys Ile Glu Asn Val Trp 
                85                  90                  95      


Asp Glu Ser Asp Asp Gly Ser Ile Arg Ile Gln Val Ser Ala Gln Phe 
            100                 105                 110         


Gly Tyr Asp Gln Ala Gly Thr Ala Asp Val Thr Lys Phe Arg Tyr Met 
        115                 120                 125             


Ser Tyr Asp His Asp His Asp Ile Lys Glu Asp Ser Val Lys Lys Ile 
    130                 135                 140                 


Ala Ile Ser Thr Ser Gly Pro Cys Arg Arg Leu Gly His Lys Gly Tyr 
145                 150                 155                 160 


Phe Leu Leu Ala Gln Cys Pro Pro Gly Asp Ser Val Thr Val Ser Ile 
                165                 170                 175     


Thr Ser Gly Ala Ser Glu Asn Ser Cys Thr Val Glu Lys Lys Ile Arg 
            180                 185                 190         


Arg Lys Phe Val Gly Arg Glu Glu Tyr Leu Phe Pro Pro Val His Gly 
        195                 200                 205             


Lys Leu Val Lys Cys His Val Tyr Asp His Leu Lys Glu Thr Ser Ala 
    210                 215                 220                 


Gly Tyr Ile Thr Met His Arg Pro Gly Pro His Ala Tyr Lys Ser Tyr 
225                 230                 235                 240 


Leu Glu Glu Ala Ser Gly Glu Val Tyr Ile Lys Pro Pro Ser Gly Lys 
                245                 250                 255     


Asn Val Thr Tyr Glu Cys Lys Cys Gly Asp Tyr Ser Thr Gly Ile Val 
            260                 265                 270         


Ser Thr Arg Thr Lys Met Asn Gly Cys Thr Lys Ala Lys Gln Cys Ile 
        275                 280                 285             


Ala Tyr Lys Ser Asp Gln Thr Lys Trp Val Tyr Asn Ser Pro Asp Leu 
    290                 295                 300                 


Ile Arg His Thr Asp His Ser Val Gln Gly Lys Leu His Ile Pro Phe 
305                 310                 315                 320 


Arg Leu Thr Pro Thr Phe Cys Pro Val Pro Leu Ala His Thr Pro Thr 
                325                 330                 335     


Val Thr Lys Trp Phe Lys Gly Ile Thr Leu His Leu Thr Ala Thr Arg 
            340                 345                 350         


Pro Thr Leu Leu Thr Thr Arg Lys Leu Gly Leu Arg Ala Asp Ala Thr 
        355                 360                 365             


Ala Glu Trp Ile Thr Gly Thr Thr Ser Arg Asn Phe Ser Val Gly Arg 
    370                 375                 380                 


Glu Gly Leu Glu Tyr Val Trp Gly Asn His Glu Pro Val Arg Val Trp 
385                 390                 395                 400 


Ala Gln Glu Ser Ala Pro Gly Asp Pro His Gly Trp Pro His Glu Ile 
                405                 410                 415     


Ile Ile His Tyr Tyr His Arg His Pro Val Tyr Thr Val Ile Val Leu 
            420                 425                 430         


Cys Gly Val Ala Leu Ala Ile Leu Val Gly Ile Ala Ser Ser Ala Ala 
        435                 440                 445             


Cys Ile Ala Lys Ala Arg Arg Asp Cys Leu Thr Pro Tyr Ala Leu Ala 
    450                 455                 460                 


Pro Asn Ala Thr Val Pro Thr Ala Leu Ala Val Leu Cys Cys Ile Arg 
465                 470                 475                 480 


Pro Thr Asn Ala Glu Thr Phe Gly Glu Thr Leu Asn His Leu Trp Phe 
                485                 490                 495     


Asn Asn Gln Pro Phe Leu Trp Ala Gln Leu Cys Ile Pro Leu Ala Ala 
            500                 505                 510         


Leu Ile Ile Leu Phe Arg Cys Phe Ser Cys Cys Met Pro Phe Leu Leu 
        515                 520                 525             


Val Ala Gly Val Cys Leu Gly Lys Val Asp Ala Phe Glu His Ala Thr 
    530                 535                 540                 


Thr Val Pro Asn Val Pro Gly Ile Pro Tyr Lys Ala Leu Val Glu Arg 
545                 550                 555                 560 


Ala Gly Tyr Ala Pro Leu Asn Leu Glu Ile Thr Val Val Ser Ser Glu 
                565                 570                 575     


Leu Thr Pro Ser Thr Asn Lys Glu Tyr Val Thr Cys Lys Phe His Thr 
            580                 585                 590         


Val Ile Pro Ser Pro Gln Val Lys Cys Cys Gly Ser Leu Glu Cys Lys 
        595                 600                 605             


Ala Ser Ser Lys Ala Asp Tyr Thr Cys Arg Val Phe Gly Gly Val Tyr 
    610                 615                 620                 


Pro Phe Met Trp Gly Gly Ala Gln Cys Phe Cys Asp Ser Glu Asn Thr 
625                 630                 635                 640 


Gln Leu Ser Glu Ala Tyr Val Glu Phe Ala Pro Asp Cys Thr Ile Asp 
                645                 650                 655     


His Ala Val Ala Leu Lys Val His Thr Ala Ala Leu Lys Val Gly Leu 
            660                 665                 670         


Arg Ile Val Tyr Gly Asn Thr Thr Ala His Leu Asp Thr Phe Val Asn 
        675                 680                 685             


Gly Val Thr Pro Gly Ser Ser Arg Asp Leu Lys Val Ile Ala Gly Pro 
    690                 695                 700                 


Ile Ser Ala Ala Phe Ser Pro Phe Asp His Lys Val Val Ile Arg Lys 
705                 710                 715                 720 


Gly Leu Val Tyr Asn Tyr Asp Phe Pro Glu Tyr Gly Ala Met Lys Pro 
                725                 730                 735     


Gly Ala Phe Gly Asp Ile Gln Ala Ser Ser Leu Asp Ala Thr Asp Ile 
            740                 745                 750         


Val Ala Arg Thr Asp Ile Arg Leu Leu Lys Pro Ser Val Lys Asn Ile 
        755                 760                 765             


His Val Pro Tyr Thr Gln Ala Val Ser Gly Tyr Glu Met Trp Lys Asn 
    770                 775                 780                 


Asn Ser Gly Arg Pro Leu Gln Glu Thr Ala Pro Phe Gly Cys Lys Ile 
785                 790                 795                 800 


Glu Val Glu Pro Leu Arg Ala Ser Asn Cys Ala Tyr Gly His Ile Pro 
                805                 810                 815     


Ile Ser Ile Asp Ile Pro Asp Ala Ala Phe Val Arg Ser Ser Glu Ser 
            820                 825                 830         


Pro Thr Ile Leu Glu Val Ser Cys Thr Val Ala Asp Cys Ile Tyr Ser 
        835                 840                 845             


Ala Asp Phe Gly Gly Ser Leu Thr Leu Gln Tyr Lys Ala Asp Arg Glu 
    850                 855                 860                 


Gly His Cys Pro Val His Ser His Ser Thr Thr Ala Val Leu Lys Glu 
865                 870                 875                 880 


Ala Thr Thr His Val Thr Ala Thr Gly Ser Ile Thr Leu His Phe Ser 
                885                 890                 895     


Thr Ser Ser Pro Gln Ala Asn Phe Ile Val Ser Leu Cys Gly Lys Lys 
            900                 905                 910         


Thr Thr Cys Asn Ala Glu Cys Lys Pro Pro Ala Asp His Ile Ile Gly 
        915                 920                 925             


Glu Pro His Lys Val Asp Gln Glu Phe Gln Ala Ala Val Ser Lys Thr 
    930                 935                 940                 


Ser Trp Asn Trp Leu Leu Ala Leu Phe Gly Gly Ala Ser Ser Leu Ile 
945                 950                 955                 960 


Ala Val Gly Leu Ile Val Leu Val Cys Ser Ser Met Leu Ile Asn Thr 
                965                 970                 975     


Arg Arg 
        


<210>  65
<211>  987
<212>  PRT
<213>  Semliki Forest virus

<400>  65

Met Ser Ala Pro Leu Ile Thr Ala Met Cys Val Leu Ala Asn Ala Thr 
1               5                   10                  15      


Phe Pro Cys Phe Gln Pro Pro Cys Val Pro Cys Cys Tyr Glu Asn Asn 
            20                  25                  30          


Ala Glu Ala Thr Leu Arg Met Leu Glu Asp Asn Val Asp Arg Pro Gly 
        35                  40                  45              


Tyr Tyr Asp Leu Leu Gln Ala Ala Leu Thr Cys Arg Asn Gly Thr Arg 
    50                  55                  60                  


His Arg Arg Ser Val Ser Gln His Phe Asn Val Tyr Lys Ala Thr Arg 
65                  70                  75                  80  


Pro Tyr Ile Ala Tyr Cys Ala Asp Cys Gly Ala Gly His Ser Cys His 
                85                  90                  95      


Ser Pro Val Ala Ile Glu Ala Val Arg Ser Glu Ala Thr Asp Gly Met 
            100                 105                 110         


Leu Lys Ile Gln Phe Ser Ala Gln Ile Gly Ile Asp Lys Ser Asp Asn 
        115                 120                 125             


His Asp Tyr Thr Lys Ile Arg Tyr Ala Asp Gly His Ala Ile Glu Asn 
    130                 135                 140                 


Ala Val Arg Ser Ser Leu Lys Val Ala Thr Ser Gly Asp Cys Phe Val 
145                 150                 155                 160 


His Gly Thr Met Gly His Phe Ile Leu Ala Lys Cys Pro Pro Gly Glu 
                165                 170                 175     


Phe Leu Gln Val Ser Ile Gln Asp Thr Arg Asn Ala Val Arg Ala Cys 
            180                 185                 190         


Arg Ile Gln Tyr His His Asp Pro Gln Pro Val Gly Arg Glu Lys Phe 
        195                 200                 205             


Thr Ile Arg Pro His Tyr Gly Lys Glu Ile Pro Cys Thr Thr Tyr Gln 
    210                 215                 220                 


Gln Thr Thr Ala Glu Thr Val Glu Glu Ile Asp Met His Met Pro Pro 
225                 230                 235                 240 


Asp Thr Pro Asp Arg Thr Leu Leu Ser Gln Gln Ser Gly Asn Val Lys 
                245                 250                 255     


Ile Thr Val Gly Gly Lys Lys Val Lys Tyr Asn Cys Thr Cys Gly Thr 
            260                 265                 270         


Gly Asn Val Gly Thr Thr Asn Ser Asp Met Thr Ile Asn Thr Cys Leu 
        275                 280                 285             


Ile Glu Gln Cys His Val Ser Val Thr Asp His Lys Lys Trp Gln Phe 
    290                 295                 300                 


Asn Ser Pro Phe Val Pro Arg Ala Asp Glu Pro Ala Arg Lys Gly Lys 
305                 310                 315                 320 


Val His Ile Pro Phe Pro Leu Asp Asn Ile Thr Cys Arg Val Pro Met 
                325                 330                 335     


Ala Arg Glu Pro Thr Val Ile His Gly Lys Arg Glu Val Thr Leu His 
            340                 345                 350         


Leu His Pro Asp His Pro Thr Leu Phe Ser Tyr Arg Thr Leu Gly Glu 
        355                 360                 365             


Asp Pro Gln Tyr His Glu Glu Trp Val Thr Ala Ala Val Glu Arg Thr 
    370                 375                 380                 


Ile Pro Val Pro Val Asp Gly Met Glu Tyr His Trp Gly Asn Asn Asp 
385                 390                 395                 400 


Pro Val Arg Leu Trp Ser Gln Leu Thr Thr Glu Gly Lys Pro His Gly 
                405                 410                 415     


Trp Pro His Gln Ile Val Gln Tyr Tyr Tyr Gly Leu Tyr Pro Ala Ala 
            420                 425                 430         


Thr Val Ser Ala Val Val Gly Met Ser Leu Leu Ala Leu Ile Ser Ile 
        435                 440                 445             


Phe Ala Ser Cys Tyr Met Leu Val Ala Ala Arg Ser Lys Cys Leu Thr 
    450                 455                 460                 


Pro Tyr Ala Leu Thr Pro Gly Ala Ala Val Pro Trp Thr Leu Gly Ile 
465                 470                 475                 480 


Leu Cys Cys Ala Pro Arg Ala His Ala Ala Ser Val Ala Glu Thr Met 
                485                 490                 495     


Ala Tyr Leu Trp Asp Gln Asn Gln Ala Leu Phe Trp Leu Glu Phe Ala 
            500                 505                 510         


Ala Pro Val Ala Cys Ile Leu Ile Ile Thr Tyr Cys Leu Arg Asn Val 
        515                 520                 525             


Leu Cys Cys Cys Lys Ser Leu Ser Phe Leu Val Leu Leu Ser Leu Gly 
    530                 535                 540                 


Ala Thr Ala Arg Ala Tyr Glu His Ser Thr Val Met Pro Asn Val Val 
545                 550                 555                 560 


Gly Phe Pro Tyr Lys Ala His Ile Glu Arg Pro Gly Tyr Ser Pro Leu 
                565                 570                 575     


Thr Leu Gln Met Gln Val Val Glu Thr Ser Leu Glu Pro Thr Leu Asn 
            580                 585                 590         


Leu Glu Tyr Ile Thr Cys Glu Tyr Lys Thr Val Val Pro Ser Pro Tyr 
        595                 600                 605             


Val Lys Cys Cys Gly Ala Ser Glu Cys Ser Thr Lys Glu Lys Pro Asp 
    610                 615                 620                 


Tyr Gln Cys Lys Val Tyr Thr Gly Val Tyr Pro Phe Met Trp Gly Gly 
625                 630                 635                 640 


Ala Tyr Cys Phe Cys Asp Ser Glu Asn Thr Gln Leu Ser Glu Ala Tyr 
                645                 650                 655     


Val Asp Arg Ser Asp Val Cys Arg His Asp His Ala Ser Ala Tyr Lys 
            660                 665                 670         


Ala His Thr Ala Ser Leu Lys Ala Lys Val Arg Val Met Tyr Gly Asn 
        675                 680                 685             


Val Asn Gln Thr Val Asp Val Tyr Val Asn Gly Asp His Ala Val Thr 
    690                 695                 700                 


Ile Gly Gly Thr Gln Phe Ile Phe Gly Pro Leu Ser Ser Ala Trp Thr 
705                 710                 715                 720 


Pro Phe Asp Asn Lys Ile Val Val Tyr Lys Asp Glu Val Phe Asn Gln 
                725                 730                 735     


Asp Phe Pro Pro Tyr Gly Ser Gly Gln Pro Gly Arg Phe Gly Asp Ile 
            740                 745                 750         


Gln Ser Arg Thr Val Glu Ser Asn Asp Leu Tyr Ala Asn Thr Ala Leu 
        755                 760                 765             


Lys Leu Ala Arg Pro Ser Pro Gly Met Val His Val Pro Tyr Thr Gln 
    770                 775                 780                 


Thr Pro Ser Gly Phe Lys Tyr Trp Leu Lys Glu Lys Gly Thr Ala Leu 
785                 790                 795                 800 


Asn Thr Lys Ala Pro Phe Gly Cys Gln Ile Lys Thr Asn Pro Val Arg 
                805                 810                 815     


Ala Met Asn Cys Ala Val Gly Asn Ile Pro Val Ser Met Asn Leu Pro 
            820                 825                 830         


Asp Ser Ala Phe Thr Arg Ile Val Glu Ala Pro Thr Ile Ile Asp Leu 
        835                 840                 845             


Thr Cys Thr Val Ala Thr Cys Thr His Ser Ser Asp Phe Gly Gly Val 
    850                 855                 860                 


Leu Thr Leu Thr Tyr Lys Thr Asn Lys Asn Gly Asp Cys Ser Val His 
865                 870                 875                 880 


Ser His Ser Asn Val Ala Thr Leu Gln Glu Ala Thr Ala Lys Val Lys 
                885                 890                 895     


Thr Ala Gly Lys Val Thr Leu His Phe Ser Thr Ala Ser Ala Ser Pro 
            900                 905                 910         


Ser Phe Val Val Ser Leu Cys Ser Ala Arg Ala Thr Cys Ser Ala Ser 
        915                 920                 925             


Cys Glu Pro Pro Lys Asp His Ile Val Pro Tyr Ala Ala Ser His Ser 
    930                 935                 940                 


Asn Val Val Phe Pro Asp Met Ser Gly Thr Ala Leu Ser Trp Val Gln 
945                 950                 955                 960 


Lys Ile Ser Gly Gly Leu Gly Ala Phe Ala Ile Gly Ala Ile Leu Val 
                965                 970                 975     


Leu Val Val Val Thr Cys Ile Gly Leu Arg Arg 
            980                 985         


<210>  66
<211>  982
<212>  PRT
<213>  Sindbis virus

<400>  66

Met Ser Ala Ala Pro Leu Val Thr Ala Met Cys Leu Leu Gly Asn Val 
1               5                   10                  15      


Ser Phe Pro Cys Asp Arg Pro Pro Thr Cys Tyr Thr Arg Glu Pro Ser 
            20                  25                  30          


Arg Ala Leu Asp Ile Leu Glu Glu Asn Val Asn His Glu Ala Tyr Asp 
        35                  40                  45              


Thr Leu Leu Asn Ala Ile Leu Arg Cys Gly Ser Ser Gly Arg Ser Lys 
    50                  55                  60                  


Arg Ser Val Ile Asp Asp Phe Thr Leu Thr Ser Pro Tyr Leu Gly Thr 
65                  70                  75                  80  


Cys Ser Tyr Cys His His Thr Val Pro Cys Phe Ser Pro Val Lys Ile 
                85                  90                  95      


Glu Gln Val Trp Asp Glu Ala Asp Asp Asn Thr Ile Arg Ile Gln Thr 
            100                 105                 110         


Ser Ala Gln Phe Gly Tyr Asp Gln Ser Gly Ala Ala Ser Ala Asn Lys 
        115                 120                 125             


Tyr Arg Tyr Met Ser Leu Lys Gln Asp His Thr Val Lys Glu Gly Thr 
    130                 135                 140                 


Met Asp Asp Ile Lys Ile Ser Thr Ser Gly Pro Cys Arg Arg Leu Ser 
145                 150                 155                 160 


Tyr Lys Gly Tyr Phe Leu Leu Ala Lys Cys Pro Pro Gly Asp Ser Val 
                165                 170                 175     


Thr Val Ser Ile Val Ser Ser Asn Ser Ala Thr Ser Cys Thr Leu Ala 
            180                 185                 190         


Arg Lys Ile Lys Pro Lys Phe Val Gly Arg Glu Lys Tyr Asp Leu Pro 
        195                 200                 205             


Pro Val His Gly Lys Lys Ile Pro Cys Thr Val Tyr Asp Arg Leu Lys 
    210                 215                 220                 


Glu Thr Thr Ala Gly Tyr Ile Thr Met His Arg Pro Arg Pro His Ala 
225                 230                 235                 240 


Tyr Thr Ser Tyr Leu Glu Glu Ser Ser Gly Lys Val Tyr Ala Lys Pro 
                245                 250                 255     


Pro Ser Gly Lys Asn Ile Thr Tyr Glu Cys Lys Cys Gly Asp Tyr Lys 
            260                 265                 270         


Thr Gly Thr Val Ser Thr Arg Thr Glu Ile Thr Gly Cys Thr Ala Ile 
        275                 280                 285             


Lys Gln Cys Val Ala Tyr Lys Ser Asp Gln Thr Lys Trp Val Phe Asn 
    290                 295                 300                 


Ser Pro Asp Leu Ile Arg His Asp Asp His Thr Ala Gln Gly Lys Leu 
305                 310                 315                 320 


His Leu Pro Phe Lys Leu Ile Pro Ser Thr Cys Met Val Pro Val Ala 
                325                 330                 335     


His Ala Pro Asn Val Ile His Gly Phe Lys His Ile Ser Leu Gln Leu 
            340                 345                 350         


Asp Thr Asp His Leu Thr Leu Leu Thr Thr Arg Arg Leu Gly Ala Asn 
        355                 360                 365             


Pro Glu Pro Thr Thr Glu Trp Ile Val Gly Lys Thr Val Arg Asn Phe 
    370                 375                 380                 


Thr Val Asp Arg Asp Gly Leu Glu Tyr Ile Trp Gly Asn His Glu Pro 
385                 390                 395                 400 


Val Arg Val Tyr Ala Gln Glu Ser Ala Pro Gly Asp Pro His Gly Trp 
                405                 410                 415     


Pro His Glu Ile Val Gln His Tyr Tyr His Arg His Pro Val Tyr Thr 
            420                 425                 430         


Ile Leu Ala Val Ala Ser Ala Thr Val Ala Met Met Ile Gly Val Thr 
        435                 440                 445             


Val Ala Val Leu Cys Ala Cys Lys Ala Arg Arg Glu Cys Leu Thr Pro 
    450                 455                 460                 


Tyr Ala Leu Ala Pro Asn Ala Val Ile Pro Thr Ser Leu Ala Leu Leu 
465                 470                 475                 480 


Cys Cys Val Arg Ser Ala Asn Ala Glu Thr Phe Thr Glu Thr Met Ser 
                485                 490                 495     


Tyr Leu Trp Ser Asn Ser Gln Pro Phe Phe Trp Val Gln Leu Cys Ile 
            500                 505                 510         


Pro Leu Ala Ala Phe Ile Val Leu Met Arg Cys Cys Ser Cys Cys Leu 
        515                 520                 525             


Pro Phe Leu Val Val Ala Gly Ala Tyr Leu Ala Lys Val Asp Ala Tyr 
    530                 535                 540                 


Glu His Ala Thr Thr Val Pro Asn Val Pro Gln Ile Pro Tyr Lys Ala 
545                 550                 555                 560 


Leu Val Glu Arg Ala Gly Tyr Ala Pro Leu Asn Leu Glu Ile Thr Val 
                565                 570                 575     


Met Ser Ser Glu Val Leu Pro Ser Thr Asn Gln Glu Tyr Ile Thr Cys 
            580                 585                 590         


Lys Phe Thr Thr Val Val Pro Ser Pro Lys Ile Lys Cys Cys Gly Ser 
        595                 600                 605             


Leu Glu Cys Gln Pro Ala Ala His Ala Asp Tyr Thr Cys Lys Val Phe 
    610                 615                 620                 


Gly Gly Val Tyr Pro Phe Met Trp Gly Gly Ala Gln Cys Phe Cys Asp 
625                 630                 635                 640 


Ser Glu Asn Ser Gln Met Ser Glu Ala Tyr Val Glu Leu Ser Ala Asp 
                645                 650                 655     


Cys Ala Ser Asp His Ala Gln Ala Ile Lys Val His Thr Ala Ala Met 
            660                 665                 670         


Lys Val Gly Leu Arg Ile Val Tyr Gly Asn Thr Thr Ser Phe Leu Asp 
        675                 680                 685             


Val Tyr Val Asn Gly Val Thr Pro Gly Thr Ser Lys Asp Leu Lys Val 
    690                 695                 700                 


Ile Ala Gly Pro Ile Ser Ala Ser Phe Thr Pro Phe Asp His Lys Val 
705                 710                 715                 720 


Val Ile His Arg Gly Leu Val Tyr Asn Tyr Asp Phe Pro Glu Tyr Gly 
                725                 730                 735     


Ala Met Lys Pro Gly Ala Phe Gly Asp Ile Gln Ala Thr Ser Leu Thr 
            740                 745                 750         


Ser Lys Asp Leu Ile Ala Ser Thr Asp Ile Arg Leu Leu Lys Pro Ser 
        755                 760                 765             


Ala Lys Asn Val His Val Pro Tyr Thr Gln Ala Ser Ser Gly Phe Glu 
    770                 775                 780                 


Met Trp Lys Asn Asn Ser Gly Arg Pro Leu Gln Glu Thr Ala Pro Phe 
785                 790                 795                 800 


Gly Cys Lys Ile Ala Val Asn Pro Leu Arg Ala Val Asp Cys Ser Tyr 
                805                 810                 815     


Gly Asn Ile Pro Ile Ser Ile Asp Ile Pro Asn Ala Ala Phe Ile Arg 
            820                 825                 830         


Thr Ser Asp Ala Pro Leu Val Ser Thr Val Lys Cys Glu Val Ser Glu 
        835                 840                 845             


Cys Thr Tyr Ser Ala Asp Phe Gly Gly Met Ala Thr Leu Gln Tyr Val 
    850                 855                 860                 


Ser Asp Arg Glu Gly Gln Cys Pro Val His Ser His Ser Ser Thr Ala 
865                 870                 875                 880 


Thr Leu Gln Glu Ser Thr Val His Val Leu Glu Lys Gly Ala Val Thr 
                885                 890                 895     


Val His Phe Ser Thr Ala Ser Pro Gln Ala Asn Phe Ile Val Ser Leu 
            900                 905                 910         


Cys Gly Lys Lys Thr Thr Cys Asn Ala Glu Cys Lys Pro Pro Ala Asp 
        915                 920                 925             


His Ile Val Ser Thr Pro His Lys Asn Asp Gln Glu Phe Gln Ala Ala 
    930                 935                 940                 


Ile Ser Lys Thr Ser Trp Ser Trp Leu Phe Ala Leu Phe Gly Gly Ala 
945                 950                 955                 960 


Ser Ser Leu Leu Ile Ile Gly Leu Met Ile Phe Ala Cys Ser Met Met 
                965                 970                 975     


Leu Thr Ser Thr Arg Arg 
            980         


<210>  67
<211>  981
<212>  PRT
<213>  Chikungunya virus (CHIKV)

<400>  67

Met Cys Leu Leu Ala Asn Thr Thr Phe Pro Cys Ser Gln Pro Pro Cys 
1               5                   10                  15      


Thr Pro Cys Cys Tyr Glu Lys Glu Pro Glu Glu Thr Leu Arg Met Leu 
            20                  25                  30          


Glu Asp Asn Val Met Arg Pro Gly Tyr Tyr Gln Leu Leu Gln Ala Ser 
        35                  40                  45              


Leu Thr Cys Ser Pro His Arg Gln Arg Arg Ser Thr Lys Asp Asn Phe 
    50                  55                  60                  


Asn Val Tyr Lys Ala Thr Arg Pro Tyr Leu Ala His Cys Pro Asp Cys 
65                  70                  75                  80  


Gly Glu Gly His Ser Cys His Ser Pro Val Ala Leu Glu Arg Ile Arg 
                85                  90                  95      


Asn Glu Ala Thr Asp Gly Thr Leu Lys Ile Gln Val Ser Leu Gln Ile 
            100                 105                 110         


Gly Ile Lys Thr Asp Asp Ser His Asp Trp Thr Lys Leu Arg Tyr Met 
        115                 120                 125             


Asp Asn His Met Pro Ala Asp Ala Glu Arg Ala Gly Leu Phe Val Arg 
    130                 135                 140                 


Thr Ser Ala Pro Cys Thr Ile Thr Gly Thr Met Gly His Phe Ile Leu 
145                 150                 155                 160 


Ala Arg Cys Pro Lys Gly Glu Thr Leu Thr Val Gly Phe Thr Asp Ser 
                165                 170                 175     


Arg Lys Ile Ser His Ser Cys Thr His Pro Phe His His Asp Pro Pro 
            180                 185                 190         


Val Ile Gly Arg Glu Lys Phe His Ser Arg Pro Gln His Gly Lys Glu 
        195                 200                 205             


Leu Pro Cys Ser Thr Tyr Val Gln Ser Thr Ala Ala Thr Thr Glu Glu 
    210                 215                 220                 


Ile Glu Val His Met Pro Pro Asp Thr Pro Asp Arg Thr Leu Met Ser 
225                 230                 235                 240 


Gln Gln Ser Gly Asn Val Lys Ile Thr Val Asn Gly Gln Thr Val Arg 
                245                 250                 255     


Tyr Lys Cys Asn Cys Gly Gly Ser Asn Glu Gly Leu Thr Thr Thr Asp 
            260                 265                 270         


Lys Val Ile Asn Asn Cys Lys Val Asp Gln Cys His Ala Ala Val Thr 
        275                 280                 285             


Asn His Lys Lys Trp Gln Tyr Asn Ser Pro Leu Val Pro Arg Asn Ala 
    290                 295                 300                 


Glu Leu Gly Asp Arg Lys Gly Lys Ile His Ile Pro Phe Pro Leu Ala 
305                 310                 315                 320 


Asn Val Thr Cys Arg Val Pro Lys Ala Arg Asn Pro Thr Val Thr Tyr 
                325                 330                 335     


Gly Lys Asn Gln Val Ile Met Leu Leu Tyr Pro Asp His Pro Thr Leu 
            340                 345                 350         


Leu Ser Tyr Arg Asn Met Gly Glu Glu Pro Asn Tyr Gln Glu Glu Trp 
        355                 360                 365             


Val Met His Lys Lys Glu Val Val Leu Thr Val Pro Thr Glu Gly Leu 
    370                 375                 380                 


Glu Val Thr Trp Gly Asn Asn Glu Pro Tyr Lys Tyr Trp Pro Gln Leu 
385                 390                 395                 400 


Ser Thr Asn Gly Thr Ala His Gly His Pro His Glu Ile Ile Leu Tyr 
                405                 410                 415     


Tyr Tyr Glu Leu Tyr Pro Thr Met Thr Val Val Val Val Ser Val Ala 
            420                 425                 430         


Thr Phe Ile Leu Leu Ser Met Val Gly Met Ala Ala Gly Met Cys Met 
        435                 440                 445             


Cys Ala Arg Arg Arg Cys Ile Thr Pro Tyr Glu Leu Thr Pro Gly Ala 
    450                 455                 460                 


Thr Val Pro Phe Leu Leu Ser Leu Ile Cys Cys Ile Arg Thr Ala Lys 
465                 470                 475                 480 


Ala Ala Thr Tyr Gln Glu Ala Ala Ile Tyr Leu Trp Asn Glu Gln Gln 
                485                 490                 495     


Pro Leu Phe Trp Leu Gln Ala Leu Ile Pro Leu Ala Ala Leu Ile Val 
            500                 505                 510         


Leu Cys Asn Cys Leu Arg Leu Leu Pro Cys Cys Cys Lys Thr Leu Ala 
        515                 520                 525             


Phe Leu Ala Val Met Ser Val Gly Ala His Thr Val Ser Ala Tyr Glu 
    530                 535                 540                 


His Val Thr Val Ile Pro Asn Thr Val Gly Val Pro Tyr Lys Thr Leu 
545                 550                 555                 560 


Val Asn Arg Pro Gly Tyr Ser Pro Met Val Leu Glu Met Glu Leu Leu 
                565                 570                 575     


Ser Val Thr Leu Glu Pro Thr Leu Ser Leu Asp Tyr Ile Thr Cys Glu 
            580                 585                 590         


Tyr Lys Thr Val Ile Pro Ser Pro Tyr Val Lys Cys Cys Gly Thr Ala 
        595                 600                 605             


Glu Cys Lys Asp Lys Asn Leu Pro Asp Tyr Ser Cys Lys Val Phe Thr 
    610                 615                 620                 


Gly Val Tyr Pro Phe Met Trp Gly Gly Ala Tyr Cys Phe Cys Asp Ala 
625                 630                 635                 640 


Glu Asn Thr Gln Leu Ser Glu Ala His Val Glu Lys Ser Glu Ser Cys 
                645                 650                 655     


Lys Thr Glu Phe Ala Ser Ala Tyr Arg Ala His Thr Ala Ser Ala Ser 
            660                 665                 670         


Ala Lys Leu Arg Val Leu Tyr Gln Gly Asn Asn Ile Thr Val Thr Ala 
        675                 680                 685             


Tyr Ala Asn Gly Asp His Ala Val Thr Val Lys Asp Ala Lys Phe Ile 
    690                 695                 700                 


Val Gly Pro Met Ser Ser Ala Trp Thr Pro Phe Asp Asn Lys Ile Val 
705                 710                 715                 720 


Val Tyr Lys Gly Asp Val Tyr Asn Met Asp Tyr Pro Pro Phe Gly Ala 
                725                 730                 735     


Gly Arg Pro Gly Gln Phe Gly Asp Ile Gln Ser Arg Thr Pro Glu Ser 
            740                 745                 750         


Lys Asp Val Tyr Ala Asn Thr Gln Leu Val Leu Gln Arg Pro Ala Val 
        755                 760                 765             


Gly Thr Val His Val Pro Tyr Ser Gln Ala Pro Ser Gly Phe Lys Tyr 
    770                 775                 780                 


Trp Leu Lys Glu Arg Gly Ala Ser Leu Gln His Thr Ala Pro Phe Gly 
785                 790                 795                 800 


Cys Gln Ile Ala Thr Asn Pro Val Arg Ala Val Asn Cys Ala Val Gly 
                805                 810                 815     


Asn Met Pro Ile Ser Ile Asp Ile Pro Glu Ala Ala Phe Thr Arg Val 
            820                 825                 830         


Val Asp Ala Pro Ser Leu Thr Asp Met Ser Cys Glu Val Pro Ala Cys 
        835                 840                 845             


Thr His Ser Ser Asp Phe Gly Gly Val Ala Ile Ile Lys Tyr Ala Ala 
    850                 855                 860                 


Ser Lys Lys Gly Lys Cys Ala Val His Ser Met Thr Asn Ala Val Thr 
865                 870                 875                 880 


Ile Arg Glu Ala Glu Ile Glu Val Glu Gly Asn Ser Gln Leu Gln Ile 
                885                 890                 895     


Ser Phe Ser Thr Ala Leu Ala Ser Ala Glu Phe Arg Val Gln Val Cys 
            900                 905                 910         


Ser Thr Gln Val His Cys Ala Ala Glu Cys His Pro Pro Lys Asp His 
        915                 920                 925             


Ile Val Asn Tyr Pro Ala Ser His Thr Thr Leu Gly Val Gln Asp Ile 
    930                 935                 940                 


Ser Ala Thr Ala Met Ser Trp Val Gln Lys Ile Thr Gly Gly Val Gly 
945                 950                 955                 960 


Leu Val Val Ala Val Ala Ala Leu Ile Leu Ile Val Val Leu Cys Val 
                965                 970                 975     


Ser Phe Ser Arg His 
            980     


<210>  68
<211>  503
<212>  PRT
<213>  Bornavirus BoDV-1

<400>  68

Met Gln Leu Ser Met Ser Ser Leu Ile Gly Phe Gly Thr Leu Val Leu 
1               5                   10                  15      


Ala Leu Ser Ala Gln Thr Phe Asp Leu Gln Gly Leu Ser Cys Asn Thr 
            20                  25                  30          


Asp Ser Thr Pro Gly Leu Ile Asp Leu Glu Ile Arg Arg Leu Cys His 
        35                  40                  45              


Thr Pro Thr Glu Asn Val Ile Ser Cys Glu Val Ser Tyr Leu Asn His 
    50                  55                  60                  


Thr Thr Ile Ser Leu Pro Ala Val His Thr Ser Cys Leu Lys Tyr His 
65                  70                  75                  80  


Cys Lys Thr Tyr Trp Gly Phe Phe Gly Ser Tyr Ser Ala Asp Arg Ile 
                85                  90                  95      


Ile Asn Arg Tyr Thr Gly Thr Val Lys Gly Cys Leu Asn Asn Ser Ala 
            100                 105                 110         


Pro Glu Asp Pro Phe Glu Cys Asn Trp Phe Tyr Cys Cys Ser Ala Ile 
        115                 120                 125             


Thr Thr Glu Ile Cys Arg Cys Ser Ile Thr Asn Val Thr Val Ala Val 
    130                 135                 140                 


Gln Thr Phe Pro Pro Phe Met Tyr Cys Ser Phe Ala Asp Cys Ser Thr 
145                 150                 155                 160 


Val Ser Gln Gln Glu Leu Glu Ser Gly Lys Ala Met Leu Ser Asp Gly 
                165                 170                 175     


Ser Thr Leu Thr Tyr Thr Pro Tyr Ile Leu Gln Ser Glu Val Val Asn 
            180                 185                 190         


Lys Thr Leu Asn Gly Thr Ile Leu Cys Asn Ser Ser Ser Lys Ile Val 
        195                 200                 205             


Ser Phe Asp Glu Phe Arg Arg Ser Tyr Ser Leu Ala Asn Gly Ser Tyr 
    210                 215                 220                 


Gln Ser Ser Ser Ile Asn Val Thr Cys Val Asn Tyr Thr Ser Ser Cys 
225                 230                 235                 240 


Arg Ser Lys Leu Arg Arg Arg Arg Arg Asp Thr Gln Gln Ile Glu Tyr 
                245                 250                 255     


Leu Val His Lys Leu Arg Pro Thr Leu Lys Asp Ala Trp Glu Asp Cys 
            260                 265                 270         


Glu Ile Leu Gln Ser Leu Leu Leu Gly Val Phe Gly Thr Gly Ile Ala 
        275                 280                 285             


Ser Ala Ser Gln Phe Leu Arg Gly Trp Leu Asn His Pro Asp Ile Ile 
    290                 295                 300                 


Gly Tyr Ile Val Asn Gly Val Gly Val Val Trp Gln Cys His Arg Val 
305                 310                 315                 320 


Asn Val Thr Phe Met Ala Trp Asn Glu Ser Thr Tyr Tyr Pro Pro Val 
                325                 330                 335     


Asp Tyr Asn Gly Arg Lys Tyr Phe Leu Asn Asp Glu Gly Arg Leu Gln 
            340                 345                 350         


Thr Asn Thr Pro Glu Ala Arg Pro Gly Leu Lys Arg Val Met Trp Phe 
        355                 360                 365             


Gly Arg Tyr Phe Leu Gly Thr Val Gly Ser Gly Val Lys Pro Arg Arg 
    370                 375                 380                 


Ile Arg Tyr Asn Lys Thr Ser His Asp Tyr His Leu Glu Glu Phe Glu 
385                 390                 395                 400 


Ala Ser Leu Asn Met Thr Pro Gln Thr Ser Ile Ala Ser Gly His Glu 
                405                 410                 415     


Thr Asp Pro Ile Asn His Ala Tyr Gly Thr Gln Ala Asp Leu Leu Pro 
            420                 425                 430         


Tyr Thr Arg Ser Ser Asn Ile Thr Ser Thr Asp Thr Gly Ser Gly Trp 
        435                 440                 445             


Val His Ile Gly Leu Pro Ser Phe Ala Phe Leu Asn Pro Leu Gly Trp 
    450                 455                 460                 


Leu Arg Asp Leu Leu Ala Trp Ala Ala Trp Leu Gly Gly Val Leu Tyr 
465                 470                 475                 480 


Leu Ile Ser Leu Cys Val Ser Leu Pro Ala Ser Phe Ala Arg Arg Arg 
                485                 490                 495     


Arg Leu Gly Arg Trp Gln Glu 
            500             


<210>  69
<211>  496
<212>  PRT
<213>  Tick-borne encephalitis virus (TBEV)

<400>  69

Ser Arg Cys Thr His Leu Glu Asn Arg Asp Phe Val Thr Gly Thr Gln 
1               5                   10                  15      


Gly Thr Thr Arg Val Thr Leu Val Leu Glu Leu Gly Gly Cys Val Thr 
            20                  25                  30          


Ile Thr Ala Glu Gly Lys Pro Ser Met Asp Val Trp Leu Asp Ala Ile 
        35                  40                  45              


Tyr Gln Glu Asn Pro Ala Gln Thr Arg Glu Tyr Cys Leu His Ala Lys 
    50                  55                  60                  


Leu Ser Asp Thr Lys Val Ala Ala Arg Cys Pro Thr Met Gly Pro Ala 
65                  70                  75                  80  


Thr Leu Ala Glu Glu His Gln Gly Gly Thr Val Cys Lys Arg Asp Gln 
                85                  90                  95      


Ser Asp Arg Gly Trp Gly Asn His Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Ile Val Ala Cys Val Lys Ala Ala Cys Glu Ala Lys Lys Lys Ala Thr 
        115                 120                 125             


Gly His Val Tyr Asp Ala Asn Lys Ile Val Tyr Thr Val Lys Val Glu 
    130                 135                 140                 


Pro His Thr Gly Asp Tyr Val Ala Ala Asn Glu Thr His Ser Gly Arg 
145                 150                 155                 160 


Lys Thr Ala Ser Phe Thr Val Ser Ser Glu Lys Thr Ile Leu Thr Met 
                165                 170                 175     


Gly Glu Tyr Gly Asp Val Ser Leu Leu Cys Arg Val Ala Ser Gly Val 
            180                 185                 190         


Asp Leu Ala Gln Thr Val Ile Leu Glu Leu Asp Lys Thr Val Glu His 
        195                 200                 205             


Leu Pro Thr Ala Trp Gln Val His Arg Asp Trp Phe Asn Asp Leu Ala 
    210                 215                 220                 


Leu Pro Trp Lys His Glu Gly Ala Arg Asn Trp Asn Asn Ala Glu Arg 
225                 230                 235                 240 


Leu Val Glu Phe Gly Ala Pro His Ala Val Lys Met Asp Val Tyr Asn 
                245                 250                 255     


Leu Gly Asp Gln Thr Gly Val Leu Leu Lys Ala Leu Ala Gly Val Pro 
            260                 265                 270         


Val Ala His Ile Glu Gly Thr Lys Tyr His Leu Lys Ser Gly His Val 
        275                 280                 285             


Thr Cys Glu Val Gly Leu Glu Lys Leu Lys Met Lys Gly Leu Thr Tyr 
    290                 295                 300                 


Thr Met Cys Asp Lys Thr Lys Phe Thr Trp Lys Arg Ala Pro Thr Asp 
305                 310                 315                 320 


Ser Gly His Asp Thr Val Val Met Glu Val Thr Phe Ser Gly Thr Lys 
                325                 330                 335     


Pro Cys Arg Ile Pro Val Arg Ala Val Ala His Gly Ser Pro Asp Val 
            340                 345                 350         


Asn Val Ala Met Leu Ile Thr Pro Asn Pro Thr Ile Glu Asn Asn Gly 
        355                 360                 365             


Gly Gly Phe Ile Glu Met Gln Leu Pro Pro Gly Asp Asn Ile Ile Tyr 
    370                 375                 380                 


Val Gly Glu Leu Ser Tyr Gln Trp Phe Gln Lys Gly Ser Ser Ile Gly 
385                 390                 395                 400 


Arg Val Phe Gln Lys Thr Lys Lys Gly Ile Glu Arg Leu Thr Val Ile 
                405                 410                 415     


Gly Glu His Ala Trp Asp Phe Gly Ser Ala Gly Gly Phe Leu Ser Ser 
            420                 425                 430         


Ile Gly Lys Ala Leu His Thr Val Leu Gly Gly Ala Phe Asn Ser Ile 
        435                 440                 445             


Phe Gly Gly Val Gly Phe Leu Pro Lys Leu Leu Leu Gly Val Ala Leu 
    450                 455                 460                 


Ala Trp Leu Gly Leu Asn Met Arg Asn Pro Thr Met Ser Met Ser Phe 
465                 470                 475                 480 


Leu Leu Ala Gly Val Leu Val Leu Ala Met Thr Leu Gly Val Gly Ala 
                485                 490                 495     


<210>  70
<211>  612
<212>  PRT
<213>  Usutu virus

<400>  70

Ser Thr Val Ser Asn Cys Pro Thr Thr Gly Glu Ala His Asn Pro Lys 
1               5                   10                  15      


Arg Ala Glu Asp Thr Tyr Val Cys Lys Ser Gly Val Thr Asp Arg Gly 
            20                  25                  30          


Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser Ile Asp Thr Cys 
        35                  40                  45              


Ala Asn Phe Thr Cys Ser Leu Lys Ala Met Gly Arg Met Ile Gln Pro 
    50                  55                  60                  


Glu Asn Val Lys Tyr Glu Val Gly Ile Phe Ile His Gly Ser Thr Ser 
65                  70                  75                  80  


Ser Asp Thr His Gly Asn Tyr Ser Ser Gln Leu Gly Ala Ser Gln Ala 
                85                  90                  95      


Gly Arg Phe Thr Ile Thr Pro Asn Ser Pro Ala Ile Thr Val Lys Met 
            100                 105                 110         


Gly Asp Tyr Gly Glu Ile Ser Val Glu Cys Glu Pro Arg Asn Gly Leu 
        115                 120                 125             


Asn Thr Glu Ala Tyr Tyr Ile Met Ser Val Gly Thr Lys His Phe Leu 
    130                 135                 140                 


Val His Arg Glu Trp Phe Asn Asp Leu Ala Leu Pro Trp Thr Ser Pro 
145                 150                 155                 160 


Ala Ser Ser Asn Trp Arg Asn Arg Glu Ile Leu Leu Glu Phe Glu Glu 
                165                 170                 175     


Pro His Ala Thr Lys Gln Ser Val Val Ala Leu Gly Ser Gln Glu Gly 
            180                 185                 190         


Ala Leu His Gln Ala Leu Ala Gly Ala Val Pro Val Ser Phe Ser Gly 
        195                 200                 205             


Ser Val Lys Leu Thr Ser Gly His Leu Lys Cys Arg Val Lys Met Glu 
    210                 215                 220                 


Lys Leu Thr Leu Lys Gly Thr Thr Tyr Gly Met Cys Thr Glu Lys Phe 
225                 230                 235                 240 


Ser Phe Ala Lys Asn Pro Ala Asp Thr Gly His Gly Thr Val Val Leu 
                245                 250                 255     


Glu Leu Gln Tyr Thr Gly Ser Asp Gly Pro Cys Lys Ile Pro Ile Ser 
            260                 265                 270         


Ile Val Ala Ser Leu Ser Asp Leu Thr Pro Ile Gly Arg Met Val Thr 
        275                 280                 285             


Ala Asn Pro Tyr Val Ala Ser Ser Glu Ala Asn Ala Lys Val Leu Val 
    290                 295                 300                 


Glu Met Glu Pro Pro Phe Gly Asp Ser Tyr Ile Val Val Gly Arg Gly 
305                 310                 315                 320 


Asp Lys Gln Ile Asn His His Trp His Lys Ala Gly Ser Ser Ile Gly 
                325                 330                 335     


Lys Ala Phe Ile Thr Thr Ile Lys Gly Ala Gln Arg Leu Ala Ala Leu 
            340                 345                 350         


Gly Asp Thr Ala Trp Asp Phe Gly Ser Val Gly Gly Ile Phe Asn Ser 
        355                 360                 365             


Val Gly Lys Ala Val His Gln Val Phe Gly Gly Ala Phe Arg Thr Leu 
    370                 375                 380                 


Phe Gly Gly Met Ser Trp Ile Thr Gln Gly Leu Met Gly Ala Leu Leu 
385                 390                 395                 400 


Leu Trp Met Gly Val Asn Ala Arg Asp Arg Ser Ile Ala Leu Val Met 
                405                 410                 415     


Leu Ala Thr Gly Gly Val Leu Leu Phe Leu Ala Thr Asn Val His Ala 
            420                 425                 430         


Asp Ser Gly Cys Ala Ile Asp Val Gly Arg Arg Glu Leu Arg Cys Gly 
        435                 440                 445             


Gln Gly Ile Phe Ile His Asn Asp Val Glu Ala Trp Val Asp Arg Tyr 
    450                 455                 460                 


Lys Phe Met Pro Glu Thr Pro Lys Gln Leu Ala Lys Val Ile Glu Gln 
465                 470                 475                 480 


Ala His Ala Lys Gly Ile Cys Gly Leu Arg Ser Val Ser Arg Leu Glu 
                485                 490                 495     


His Val Met Trp Glu Asn Ile Arg Asp Glu Leu Asn Thr Leu Leu Arg 
            500                 505                 510         


Glu Asn Ala Val Asp Leu Ser Val Val Val Glu Lys Pro Lys Gly Met 
        515                 520                 525             


Tyr Lys Ser Ala Pro Gln Arg Leu Ala Leu Thr Ser Glu Glu Phe Glu 
    530                 535                 540                 


Ile Gly Trp Lys Ala Trp Gly Lys Ser Leu Val Phe Ala Pro Glu Leu 
545                 550                 555                 560 


Ala Asn His Thr Phe Val Val Asp Gly Pro Glu Thr Lys Glu Cys Pro 
                565                 570                 575     


Asp Ala Lys Arg Ala Trp Asn Ser Leu Glu Ile Glu Asp Phe Gly Phe 
            580                 585                 590         


Gly Ile Met Ser Thr Arg Val Trp Leu Lys Val Arg Glu His Asn Thr 
        595                 600                 605             


Thr Asp Cys Asp 
    610         


<210>  71
<211>  501
<212>  PRT
<213>  St. Louis encephalitis virus

<400>  71

Phe Asn Cys Leu Gly Thr Ser Asn Arg Asp Phe Val Glu Gly Ala Ser 
1               5                   10                  15      


Gly Ala Thr Trp Ile Asp Leu Val Leu Glu Gly Gly Ser Cys Val Thr 
            20                  25                  30          


Val Met Ala Pro Glu Lys Pro Thr Leu Asp Phe Lys Val Met Lys Met 
        35                  40                  45              


Glu Ala Thr Glu Leu Ala Thr Val Arg Glu Tyr Cys Tyr Glu Ala Thr 
    50                  55                  60                  


Leu Asp Thr Leu Ser Thr Val Ala Arg Cys Pro Thr Thr Gly Glu Ala 
65                  70                  75                  80  


His Asn Thr Lys Arg Ser Asp Pro Thr Phe Val Cys Lys Arg Asp Val 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Ile Asp Thr Cys Ala Lys Phe Thr Cys Lys Ser Lys Ala Thr Gly Lys 
        115                 120                 125             


Thr Ile Leu Arg Glu Asn Ile Lys Tyr Glu Val Ala Ile Phe Val His 
    130                 135                 140                 


Gly Ser Thr Asp Ser Thr Thr His Gly Asn Tyr Phe Glu Gln Ile Gly 
145                 150                 155                 160 


Lys Asn Gln Ala Ala Arg Phe Thr Ile Ser Pro Gln Ala Pro Ser Phe 
                165                 170                 175     


Thr Ala Asn Met Gly Glu Tyr Gly Thr Val Thr Ile Asp Cys Glu Ala 
            180                 185                 190         


Arg Ser Gly Ile Asn Thr Glu Asp Tyr Tyr Val Phe Thr Val Lys Glu 
        195                 200                 205             


Lys Ser Trp Leu Val Asn Arg Asp Trp Phe His Asp Leu Asn Leu Pro 
    210                 215                 220                 


Trp Thr Ser Pro Ala Thr Thr Asp Trp Arg Asn Arg Glu Thr Leu Val 
225                 230                 235                 240 


Glu Phe Glu Glu Pro His Ala Thr Lys Gln Thr Val Val Ala Leu Gly 
                245                 250                 255     


Ser Gln Glu Gly Ala Leu His Thr Ala Leu Ala Gly Ala Ile Pro Ala 
            260                 265                 270         


Thr Val Ser Ser Ser Thr Leu Thr Leu Gln Ser Gly His Leu Lys Cys 
        275                 280                 285             


Arg Ala Lys Leu Asp Lys Val Lys Ile Lys Gly Thr Thr Tyr Gly Met 
    290                 295                 300                 


Cys Asp Ser Ala Phe Thr Phe Ser Lys Asn Pro Ala Asp Thr Gly His 
305                 310                 315                 320 


Gly Thr Val Ile Val Glu Leu Gln Tyr Thr Gly Ser Asn Gly Pro Cys 
                325                 330                 335     


Arg Val Pro Ile Ser Val Thr Ala Asn Leu Met Asp Leu Thr Pro Val 
            340                 345                 350         


Gly Arg Leu Val Thr Val Asn Pro Phe Ile Ser Thr Gly Gly Ala Asn 
        355                 360                 365             


Asn Lys Val Met Val Glu Val Glu Pro Pro Phe Gly Asp Ser Tyr Ile 
    370                 375                 380                 


Val Val Gly Arg Gly Thr Thr Gln Ile Asn Tyr His Trp His Lys Glu 
385                 390                 395                 400 


Gly Ser Ser Ile Gly Lys Ala Leu Ala Thr Thr Trp Lys Gly Ala Gln 
                405                 410                 415     


Arg Leu Ala Val Leu Gly Asp Thr Ala Trp Asp Phe Gly Ser Ile Gly 
            420                 425                 430         


Gly Val Phe Asn Ser Ile Gly Lys Ala Val His Gln Val Phe Gly Gly 
        435                 440                 445             


Ala Phe Arg Thr Leu Phe Gly Gly Met Ser Trp Ile Thr Gln Gly Leu 
    450                 455                 460                 


Leu Gly Ala Leu Leu Leu Trp Met Gly Leu Gln Ala Arg Asp Arg Ser 
465                 470                 475                 480 


Ile Ser Leu Thr Leu Leu Ala Val Gly Gly Ile Leu Ile Phe Leu Ala 
                485                 490                 495     


Thr Ser Val Gln Ala 
            500     


<210>  72
<211>  472
<212>  PRT
<213>  Yellow fever virus

<400>  72

Val Gly Pro Ala Tyr Ser Ala His Cys Ile Gly Ile Thr Asp Arg Asp 
1               5                   10                  15      


Phe Ile Glu Gly Val His Gly Gly Thr Trp Val Ser Ala Thr Leu Glu 
            20                  25                  30          


Gln Asp Lys Cys Val Thr Val Met Ala Pro Asp Lys Pro Ser Leu Asp 
        35                  40                  45              


Ile Ser Leu Glu Thr Val Ala Ile Asp Arg Pro Ala Glu Val Arg Lys 
    50                  55                  60                  


Val Cys Tyr Asn Ala Val Leu Thr His Val Lys Ile Asn Asp Lys Cys 
65                  70                  75                  80  


Pro Ser Thr Gly Glu Ala His Leu Ala Glu Glu Asn Glu Gly Asp Asn 
                85                  90                  95      


Ala Cys Lys Arg Thr Tyr Ser Asp Arg Gly Trp Gly Asn Gly Cys Gly 
            100                 105                 110         


Leu Phe Gly Lys Gly Ser Ile Val Ala Cys Ala Lys Phe Thr Cys Ala 
        115                 120                 125             


Lys Ser Met Ser Leu Phe Glu Val Asp Gln Thr Lys Ile Gln Tyr Val 
    130                 135                 140                 


Ile Arg Ala Gln Leu His Val Gly Ala Lys Gln Glu Asn Trp Asn Thr 
145                 150                 155                 160 


Asp Ile Lys Thr Leu Lys Phe Asp Ala Leu Ser Gly Ser Gln Glu Val 
                165                 170                 175     


Glu Phe Ile Gly Tyr Gly Lys Ala Thr Leu Glu Cys Gln Val Gln Thr 
            180                 185                 190         


Ala Val Asp Phe Gly Asn Ser Tyr Ile Ala Glu Met Glu Thr Glu Ser 
        195                 200                 205             


Trp Ile Val Asp Arg Gln Trp Ala Gln Asp Leu Thr Leu Pro Trp Gln 
    210                 215                 220                 


Ser Gly Ser Gly Gly Val Trp Arg Glu Met His His Leu Val Glu Phe 
225                 230                 235                 240 


Glu Pro Pro His Ala Ala Thr Ile Arg Val Leu Ala Leu Gly Asn Gln 
                245                 250                 255     


Glu Gly Ser Leu Lys Thr Ala Leu Thr Gly Ala Met Arg Val Thr Lys 
            260                 265                 270         


Asp Thr Asn Asp Asn Asn Leu Tyr Lys Leu His Gly Gly His Val Ser 
        275                 280                 285             


Cys Arg Val Lys Leu Ser Ala Leu Thr Leu Lys Gly Thr Ser Tyr Lys 
    290                 295                 300                 


Ile Cys Thr Asp Lys Met Phe Phe Val Lys Asn Pro Thr Asp Thr Gly 
305                 310                 315                 320 


His Gly Thr Val Val Met Gln Val Lys Val Ser Lys Gly Ala Pro Cys 
                325                 330                 335     


Arg Ile Pro Val Ile Val Ala Asp Asp Leu Thr Ala Ala Ile Asn Lys 
            340                 345                 350         


Gly Ile Leu Val Thr Val Asn Pro Ile Ala Ser Thr Asn Asp Asp Glu 
        355                 360                 365             


Val Leu Ile Glu Val Asn Pro Pro Phe Gly Asp Ser Tyr Ile Ile Val 
    370                 375                 380                 


Gly Arg Gly Asp Ser Arg Leu Thr Tyr Gln Trp His Lys Glu Gly Ser 
385                 390                 395                 400 


Ser Ile Gly Lys Leu Phe Thr Gln Thr Met Lys Gly Val Glu Arg Leu 
                405                 410                 415     


Ala Val Met Gly Asp Thr Ala Trp Asp Phe Ser Ser Ala Gly Gly Phe 
            420                 425                 430         


Phe Thr Ser Val Gly Lys Gly Ile His Thr Val Phe Gly Ser Ala Phe 
        435                 440                 445             


Gln Gly Leu Phe Gly Gly Leu Asn Trp Ile Thr Lys Val Ile Met Gly 
    450                 455                 460                 


Ala Val Leu Ile Trp Val Gly Ile 
465                 470         


<210>  73
<211>  495
<212>  PRT
<213>  Dengue virus 2

<400>  73

Met Arg Cys Ile Gly Ile Ser Asn Arg Asp Phe Val Glu Gly Val Ser 
1               5                   10                  15      


Gly Gly Ser Trp Val Asp Ile Val Leu Glu His Gly Ser Cys Val Thr 
            20                  25                  30          


Thr Met Ala Lys Asn Lys Pro Thr Leu Asp Phe Glu Leu Ile Lys Thr 
        35                  40                  45              


Glu Ala Lys His Pro Ala Thr Leu Arg Lys Tyr Cys Val Glu Ala Lys 
    50                  55                  60                  


Leu Thr Asn Thr Thr Thr Ala Ser Arg Cys Pro Thr Gln Gly Glu Pro 
65                  70                  75                  80  


Ser Leu Asn Glu Glu Gln Asp Lys Arg Phe Val Cys Lys His Ser Met 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Gly 
            100                 105                 110         


Ile Val Thr Cys Ala Met Phe Thr Cys Lys Lys Asn Met Glu Gly Lys 
        115                 120                 125             


Val Val Gln Pro Glu Asn Leu Glu Tyr Thr Ile Val Ile Thr Pro His 
    130                 135                 140                 


Ser Gly Glu Glu Asn Ala Val Gly Asn Asp Thr Gly Lys His Gly Lys 
145                 150                 155                 160 


Glu Ile Lys Val Thr Pro Gln Ser Ser Ile Thr Glu Ala Glu Leu Thr 
                165                 170                 175     


Gly Tyr Gly Thr Val Thr Met Glu Cys Ser Pro Arg Thr Gly Leu Asp 
            180                 185                 190         


Phe Asn Glu Met Val Leu Leu Gln Met Glu Asn Lys Ala Trp Leu Val 
        195                 200                 205             


His Arg Gln Trp Phe Leu Asp Leu Pro Leu Pro Trp Leu Pro Gly Ala 
    210                 215                 220                 


Asp Thr Gln Gly Ser Asn Trp Ile Gln Lys Glu Thr Leu Val Thr Phe 
225                 230                 235                 240 


Lys Asn Pro His Ala Lys Lys Gln Asp Val Val Val Leu Gly Ser Gln 
                245                 250                 255     


Glu Gly Ala Met His Thr Ala Leu Thr Gly Ala Thr Glu Ile Gln Met 
            260                 265                 270         


Ser Ser Gly Asn Leu Leu Phe Thr Gly His Leu Lys Cys Arg Leu Arg 
        275                 280                 285             


Met Asp Lys Leu Gln Leu Lys Gly Met Ser Tyr Ser Met Cys Thr Gly 
    290                 295                 300                 


Lys Phe Lys Val Val Lys Glu Ile Ala Glu Thr Gln His Gly Thr Ile 
305                 310                 315                 320 


Val Ile Arg Val Gln Tyr Glu Gly Asp Gly Ser Pro Cys Lys Ile Pro 
                325                 330                 335     


Phe Glu Ile Met Asp Leu Glu Lys Arg His Val Leu Gly Arg Leu Ile 
            340                 345                 350         


Thr Val Asn Pro Ile Val Thr Glu Lys Asp Ser Pro Val Asn Ile Glu 
        355                 360                 365             


Ala Glu Pro Pro Phe Gly Asp Ser Tyr Ile Ile Ile Gly Val Glu Pro 
    370                 375                 380                 


Gly Gln Leu Lys Leu Ser Trp Phe Lys Lys Gly Ser Ser Ile Gly Gln 
385                 390                 395                 400 


Met Phe Glu Thr Thr Met Arg Gly Ala Lys Arg Met Ala Ile Leu Gly 
                405                 410                 415     


Asp Thr Ala Trp Asp Phe Gly Ser Leu Gly Gly Val Phe Thr Ser Ile 
            420                 425                 430         


Gly Lys Ala Leu His Gln Val Phe Gly Ala Ile Tyr Gly Ala Ala Phe 
        435                 440                 445             


Ser Gly Val Ser Trp Thr Met Lys Ile Leu Ile Gly Val Val Ile Thr 
    450                 455                 460                 


Trp Ile Gly Met Asn Ser Arg Ser Thr Ser Leu Ser Val Ser Leu Val 
465                 470                 475                 480 


Leu Val Gly Val Val Thr Leu Tyr Leu Gly Val Met Val Gln Ala 
                485                 490                 495 


<210>  74
<211>  493
<212>  PRT
<213>  Dengue virus 3

<400>  74

Met Arg Cys Val Gly Val Gly Asn Arg Asp Phe Val Glu Gly Leu Ser 
1               5                   10                  15      


Gly Ala Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          


Thr Met Ala Lys Asn Lys Pro Thr Leu Asp Ile Glu Leu Gln Lys Thr 
        35                  40                  45              


Glu Ala Thr Gln Leu Ala Thr Leu Arg Lys Leu Cys Ile Glu Gly Lys 
    50                  55                  60                  


Ile Thr Asn Ile Thr Thr Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 
65                  70                  75                  80  


Ile Leu Pro Glu Glu Gln Asp Gln Asn Tyr Val Cys Lys His Thr Tyr 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Leu Val Thr Cys Ala Lys Phe Gln Cys Leu Glu Ser Ile Glu Gly Lys 
        115                 120                 125             


Val Val Gln His Glu Asn Leu Lys Tyr Thr Val Ile Ile Thr Val His 
    130                 135                 140                 


Thr Gly Asp Gln His Gln Val Gly Asn Glu Thr Gln Gly Val Thr Ala 
145                 150                 155                 160 


Glu Ile Thr Ser Gln Ala Ser Thr Ala Glu Ala Ile Leu Pro Glu Tyr 
                165                 170                 175     


Gly Thr Leu Gly Leu Glu Cys Ser Pro Arg Thr Gly Leu Asp Phe Asn 
            180                 185                 190         


Glu Met Ile Leu Leu Thr Met Lys Asn Lys Ala Trp Met Val His Arg 
        195                 200                 205             


Gln Trp Phe Phe Asp Leu Pro Leu Pro Trp Thr Ser Gly Ala Thr Thr 
    210                 215                 220                 


Lys Thr Pro Thr Trp Asn Arg Lys Glu Leu Leu Val Thr Phe Lys Asn 
225                 230                 235                 240 


Ala His Ala Lys Lys Gln Glu Val Val Val Leu Gly Ser Gln Glu Gly 
                245                 250                 255     


Ala Met His Thr Ala Leu Thr Gly Ala Thr Glu Ile Gln Thr Ser Gly 
            260                 265                 270         


Gly Thr Ser Ile Phe Ala Gly His Leu Lys Cys Arg Leu Lys Met Asp 
        275                 280                 285             


Lys Leu Lys Leu Lys Gly Met Ser Tyr Ala Met Cys Leu Asn Thr Phe 
    290                 295                 300                 


Val Leu Lys Lys Glu Val Ser Glu Thr Gln His Gly Thr Ile Leu Ile 
305                 310                 315                 320 


Lys Val Glu Tyr Lys Gly Glu Asp Ala Pro Cys Lys Ile Pro Phe Ser 
                325                 330                 335     


Thr Glu Asp Gly Gln Gly Lys Ala His Asn Gly Arg Leu Ile Thr Ala 
            340                 345                 350         


Asn Pro Val Val Thr Lys Lys Glu Glu Pro Val Asn Ile Glu Ala Glu 
        355                 360                 365             


Pro Pro Phe Gly Glu Ser Asn Ile Val Ile Gly Ile Gly Asp Lys Ala 
    370                 375                 380                 


Leu Lys Ile Asn Trp Tyr Arg Lys Gly Ser Ser Ile Gly Lys Met Phe 
385                 390                 395                 400 


Glu Ala Thr Ala Arg Gly Ala Arg Arg Met Ala Ile Leu Gly Asp Thr 
                405                 410                 415     


Ala Trp Asp Phe Gly Ser Val Gly Gly Val Leu Asn Ser Leu Gly Lys 
            420                 425                 430         


Met Val His Gln Ile Phe Gly Ser Ala Tyr Thr Ala Leu Phe Ser Gly 
        435                 440                 445             


Val Ser Trp Ile Met Lys Ile Gly Ile Gly Val Leu Leu Thr Trp Ile 
    450                 455                 460                 


Gly Leu Asn Ser Lys Asn Thr Ser Met Ser Phe Ser Cys Ile Ala Ile 
465                 470                 475                 480 


Gly Ile Ile Thr Leu Tyr Leu Gly Val Val Val Gln Ala 
                485                 490             


<210>  75
<211>  72
<212>  PRT
<213>  Dengue virus 4

<400>  75

Phe Gly Ser Val Gly Gly Leu Phe Thr Ser Leu Gly Lys Ala Val His 
1               5                   10                  15      


Gln Val Phe Gly Ser Val Tyr Thr Thr Met Phe Gly Gly Val Ser Trp 
            20                  25                  30          


Met Ile Arg Ile Leu Ile Gly Phe Leu Val Leu Trp Ile Gly Thr Asn 
        35                  40                  45              


Ser Arg Asn Thr Ser Met Ala Met Thr Cys Ile Ala Val Gly Gly Ile 
    50                  55                  60                  


Thr Leu Phe Leu Gly Phe Thr Val 
65                  70          


<210>  76
<211>  501
<212>  PRT
<213>  Murray Valley encephalitis virus (MVEV)

<400>  76

Phe Asn Cys Leu Gly Met Ser Ser Arg Asp Phe Ile Glu Gly Ala Ser 
1               5                   10                  15      


Gly Ala Thr Trp Val Asp Leu Val Leu Glu Gly Asp Ser Cys Ile Thr 
            20                  25                  30          


Ile Met Ala Ala Asp Lys Pro Thr Leu Asp Ile Arg Met Met Asn Ile 
        35                  40                  45              


Glu Ala Thr Asn Leu Ala Leu Val Arg Asn Tyr Cys Tyr Ala Ala Thr 
    50                  55                  60                  


Val Ser Asp Val Ser Thr Val Ser Asn Cys Pro Thr Thr Gly Glu Ser 
65                  70                  75                  80  


His Asn Thr Lys Arg Ala Asp His Asn Tyr Leu Cys Lys Arg Gly Val 
                85                  90                  95      


Thr Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Ile Asp Thr Cys Ala Lys Phe Thr Cys Ser Asn Ser Ala Ala Gly Arg 
        115                 120                 125             


Leu Ile Leu Pro Glu Asp Ile Lys Tyr Glu Val Gly Val Phe Val His 
    130                 135                 140                 


Gly Ser Thr Asp Ser Thr Ser His Gly Asn Tyr Ser Thr Gln Ile Gly 
145                 150                 155                 160 


Ala Asn Gln Ala Val Arg Phe Thr Ile Ser Pro Asn Ala Pro Ala Ile 
                165                 170                 175     


Thr Ala Lys Met Gly Asp Tyr Gly Glu Val Thr Val Glu Cys Glu Pro 
            180                 185                 190         


Arg Ser Gly Leu Asn Thr Glu Ala Tyr Tyr Val Met Thr Ile Gly Thr 
        195                 200                 205             


Lys His Phe Leu Val His Arg Glu Trp Phe Asn Asp Leu Leu Leu Pro 
    210                 215                 220                 


Trp Thr Ser Pro Ala Ser Thr Glu Trp Arg Asn Arg Glu Ile Leu Val 
225                 230                 235                 240 


Glu Phe Glu Glu Pro His Ala Thr Lys Gln Ser Val Val Ala Leu Gly 
                245                 250                 255     


Ser Gln Glu Gly Ala Leu His Gln Ala Leu Ala Gly Ala Ile Pro Val 
            260                 265                 270         


Glu Phe Ser Ser Ser Thr Leu Lys Leu Thr Ser Gly His Leu Lys Cys 
        275                 280                 285             


Arg Val Lys Met Glu Lys Leu Lys Leu Lys Gly Thr Thr Tyr Gly Met 
    290                 295                 300                 


Cys Thr Glu Lys Phe Thr Phe Ser Lys Asn Pro Ala Asp Thr Gly His 
305                 310                 315                 320 


Gly Thr Val Val Leu Glu Leu Gln Tyr Thr Gly Ser Asp Gly Pro Cys 
                325                 330                 335     


Lys Ile Pro Ile Ser Ser Val Ala Ser Leu Asn Asp Met Thr Pro Val 
            340                 345                 350         


Gly Arg Met Val Thr Ala Asn Pro Tyr Val Ala Ser Ser Thr Ala Asn 
        355                 360                 365             


Ala Lys Val Leu Val Glu Ile Glu Pro Pro Phe Gly Asp Ser Tyr Ile 
    370                 375                 380                 


Val Val Gly Arg Gly Asp Lys Gln Ile Asn His His Trp His Lys Glu 
385                 390                 395                 400 


Gly Ser Ser Ile Gly Lys Ala Phe Ser Thr Thr Leu Lys Gly Ala Gln 
                405                 410                 415     


Arg Leu Ala Ala Leu Gly Asp Thr Ala Trp Asp Phe Gly Ser Val Gly 
            420                 425                 430         


Gly Val Phe Asn Ser Ile Gly Lys Ala Val His Gln Val Phe Gly Gly 
        435                 440                 445             


Ala Phe Arg Thr Leu Phe Gly Gly Met Ser Trp Ile Ser Pro Gly Leu 
    450                 455                 460                 


Leu Gly Ala Leu Leu Leu Trp Met Gly Val Asn Ala Arg Asp Lys Ser 
465                 470                 475                 480 


Ile Ala Leu Ala Phe Leu Ala Thr Gly Gly Val Leu Leu Phe Leu Ala 
                485                 490                 495     


Thr Asn Val His Ala 
            500     


<210>  77
<211>  497
<212>  PRT
<213>  Powassan virus

<400>  77

Thr Arg Cys Thr His Leu Glu Asn Arg Asp Phe Val Thr Gly Thr Gln 
1               5                   10                  15      


Gly Thr Thr Arg Val Ser Leu Val Leu Glu Leu Gly Gly Cys Val Thr 
            20                  25                  30          


Ile Thr Ala Glu Gly Lys Pro Ser Ile Asp Val Trp Leu Glu Asp Ile 
        35                  40                  45              


Phe Gln Glu Ser Pro Ala Glu Thr Arg Glu Tyr Cys Leu His Ala Lys 
    50                  55                  60                  


Leu Thr Asn Thr Lys Val Glu Ala Arg Cys Pro Thr Thr Gly Pro Ala 
65                  70                  75                  80  


Thr Leu Pro Glu Glu His Gln Ala Asn Met Val Cys Lys Arg Asp Gln 
                85                  90                  95      


Ser Asp Arg Gly Trp Gly Asn His Cys Gly Phe Phe Gly Lys Gly Ser 
            100                 105                 110         


Ile Val Ala Cys Ala Lys Phe Glu Cys Glu Glu Ala Lys Lys Ala Met 
        115                 120                 125             


Gly His Val Tyr Asp Ser Thr Lys Ile Thr Tyr Val Val Lys Val Glu 
    130                 135                 140                 


Pro His Thr Gly Asp Tyr Leu Ala Ala Asn Glu Thr Asn Ser Asn Arg 
145                 150                 155                 160 


Lys Ser Ala Gln Phe Thr Val Ala Ser Glu Lys Val Ile Leu Arg Leu 
                165                 170                 175     


Gly Asp Tyr Gly Asp Val Ser Leu Thr Cys Lys Val Ala Ser Gly Ile 
            180                 185                 190         


Asp Val Ala Gln Thr Val Val Met Ser Leu Asp Ser Ser Lys Asp His 
        195                 200                 205             


Leu Pro Ser Ala Trp Gln Val His Arg Asp Trp Phe Glu Asp Leu Ala 
    210                 215                 220                 


Leu Pro Trp Lys His Lys Asp Asn Gln Asp Trp Asn Ser Val Glu Lys 
225                 230                 235                 240 


Leu Val Glu Phe Gly Pro Pro His Ala Val Lys Met Asp Val Phe Asn 
                245                 250                 255     


Leu Gly Asp Gln Thr Ala Val Leu Leu Lys Ser Leu Ala Gly Val Pro 
            260                 265                 270         


Leu Ala Ser Val Glu Gly Gln Lys Tyr His Leu Lys Ser Gly His Val 
        275                 280                 285             


Thr Cys Asp Val Gly Leu Glu Lys Leu Lys Leu Lys Gly Thr Thr Tyr 
    290                 295                 300                 


Ser Met Cys Asp Lys Ala Lys Phe Lys Trp Lys Arg Val Pro Val Asp 
305                 310                 315                 320 


Ser Gly His Asp Thr Val Val Met Glu Val Ser Tyr Thr Gly Ser Asp 
                325                 330                 335     


Lys Pro Cys Arg Ile Pro Val Arg Ala Val Ala His Gly Val Pro Ala 
            340                 345                 350         


Val Asn Val Ala Met Leu Ile Thr Pro Asn Pro Thr Ile Glu Thr Asn 
        355                 360                 365             


Gly Gly Gly Phe Ile Glu Met Gln Leu Pro Pro Gly Asp Asn Ile Ile 
    370                 375                 380                 


Tyr Val Gly Asp Leu Ser Gln Gln Trp Phe Gln Lys Gly Ser Thr Ile 
385                 390                 395                 400 


Gly Arg Met Phe Glu Lys Thr Arg Arg Gly Leu Glu Arg Leu Ser Val 
                405                 410                 415     


Val Gly Glu His Ala Trp Asp Phe Gly Ser Val Gly Gly Val Leu Ser 
            420                 425                 430         


Ser Val Gly Lys Ala Ile His Thr Val Leu Gly Gly Ala Phe Asn Thr 
        435                 440                 445             


Leu Phe Gly Gly Val Gly Phe Ile Pro Lys Met Leu Leu Gly Val Ala 
    450                 455                 460                 


Leu Val Trp Leu Gly Leu Asn Ala Arg Asn Pro Thr Met Ser Met Thr 
465                 470                 475                 480 


Phe Leu Ala Val Gly Ala Leu Thr Leu Met Met Thr Met Gly Val Gly 
                485                 490                 495     


Ala 
    


<210>  78
<211>  564
<212>  PRT
<213>  Influenza A virus

<400>  78

Met Glu Arg Ile Val Leu Leu Leu Ala Ile Val Ser Leu Val Lys Ser 
1               5                   10                  15      


Asp Gln Ile Cys Ile Gly Tyr His Ala Asn Lys Ser Thr Lys Gln Val 
            20                  25                  30          


Asp Thr Ile Met Glu Lys Asn Val Thr Val Thr His Ala Gln Asp Ile 
        35                  40                  45              


Leu Glu Arg Thr His Asn Gly Lys Leu Cys Ser Leu Asn Gly Val Lys 
    50                  55                  60                  


Pro Leu Ile Leu Arg Asp Cys Ser Val Ala Gly Trp Leu Leu Gly Asn 
65                  70                  75                  80  


Pro Met Cys Asp Glu Phe Leu Asn Val Pro Glu Trp Ser Tyr Ile Val 
                85                  90                  95      


Glu Lys Asp Asn Pro Ile Asn Ser Leu Cys Tyr Pro Gly Asp Phe Asn 
            100                 105                 110         


Asp Tyr Glu Glu Leu Lys His Leu Leu Ser Ser Thr Asn His Phe Glu 
        115                 120                 125             


Lys Ile Gln Ile Ile Pro Arg Ser Ser Trp Ser Asn His Asp Ala Ser 
    130                 135                 140                 


Ser Gly Val Ser Ser Ala Cys Pro Tyr Ile Gly Arg Ser Ser Phe Phe 
145                 150                 155                 160 


Arg Asn Val Val Trp Leu Ile Lys Lys Asp Asn Ala Tyr Pro Thr Ile 
                165                 170                 175     


Lys Arg Ser Tyr Asn Asn Thr Asn Gln Glu Asp Leu Leu Ile Leu Trp 
            180                 185                 190         


Gly Ile His His Pro Asn Asp Ala Ala Glu Gln Thr Lys Leu Tyr Gln 
        195                 200                 205             


Asn Pro Thr Thr Tyr Val Ser Val Gly Thr Ser Thr Leu Asn Gln Arg 
    210                 215                 220                 


Ser Ile Pro Glu Ile Ala Thr Arg Pro Lys Val Asn Gly Gln Ser Gly 
225                 230                 235                 240 


Arg Met Glu Phe Phe Trp Thr Ile Leu Lys Pro Asn Asp Ala Ile Asn 
                245                 250                 255     


Phe Glu Ser Asn Gly Asn Phe Ile Ala Pro Glu Tyr Ala Tyr Lys Ile 
            260                 265                 270         


Val Lys Lys Gly Asp Ser Ala Ile Met Lys Ser Gly Leu Ala Tyr Gly 
        275                 280                 285             


Asn Cys Asp Thr Lys Cys Gln Thr Pro Val Gly Ala Ile Asn Ser Ser 
    290                 295                 300                 


Met Pro Phe His Asn Ile His Pro His Thr Ile Gly Glu Cys Pro Lys 
305                 310                 315                 320 


Tyr Val Lys Ser Asp Arg Leu Val Leu Ala Thr Gly Leu Arg Asn Val 
                325                 330                 335     


Pro Gln Arg Lys Lys Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile 
            340                 345                 350         


Glu Gly Gly Trp Gln Gly Met Val Asp Gly Trp Tyr Gly Tyr His His 
        355                 360                 365             


Ser Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Lys Glu Ser Thr Gln 
    370                 375                 380                 


Lys Ala Ile Asp Gly Ile Thr Asn Lys Val Asn Ser Ile Ile Asp Lys 
385                 390                 395                 400 


Met Asn Thr Gln Phe Lys Ala Val Gly Lys Glu Phe Asn Asn Leu Glu 
                405                 410                 415     


Arg Arg Val Glu Asn Leu Asn Lys Lys Met Glu Asp Gly Phe Leu Asp 
            420                 425                 430         


Val Trp Thr Tyr Asn Val Glu Leu Leu Val Leu Met Glu Asn Glu Arg 
        435                 440                 445             


Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Asp Lys Val 
    450                 455                 460                 


Arg Leu Gln Leu Lys Asp Asn Ala Arg Glu Leu Gly Asn Gly Cys Phe 
465                 470                 475                 480 


Glu Phe Tyr His Lys Cys Asp Asn Glu Cys Met Glu Ser Val Arg Asn 
                485                 490                 495     


Gly Thr Tyr Asp Tyr Pro Gln Tyr Ser Glu Glu Ala Arg Leu Asn Arg 
            500                 505                 510         


Glu Glu Ile Ser Gly Val Lys Leu Glu Ser Met Gly Val Tyr Gln Ile 
        515                 520                 525             


Leu Ser Ile Tyr Ser Thr Val Ala Ser Ser Leu Ala Leu Ala Ile Met 
    530                 535                 540                 


Ile Ala Gly Leu Ser Phe Trp Met Cys Ser Asn Gly Ser Leu Gln Cys 
545                 550                 555                 560 


Arg Ile Cys Ile 
                


<210>  79
<211>  560
<212>  PRT
<213>  Influenza A virus

<400>  79

Met Asn Thr Gln Ile Leu Val Phe Ala Leu Ile Ala Ile Ile Pro Thr 
1               5                   10                  15      


Asn Ala Asp Lys Ile Cys Leu Gly His His Ala Val Ser Asn Gly Thr 
            20                  25                  30          


Lys Val Asn Thr Leu Thr Glu Arg Gly Val Glu Val Val Asn Ala Thr 
        35                  40                  45              


Glu Thr Val Glu Arg Thr Asn Ile Pro Arg Ile Cys Ser Lys Gly Lys 
    50                  55                  60                  


Arg Thr Val Asp Leu Gly Gln Cys Gly Leu Leu Gly Thr Ile Thr Gly 
65                  70                  75                  80  


Pro Pro Gln Cys Asp Gln Phe Leu Glu Phe Ser Ala Asp Leu Ile Ile 
                85                  90                  95      


Glu Arg Arg Glu Gly Ser Asp Val Cys Tyr Pro Gly Lys Phe Val Asn 
            100                 105                 110         


Glu Glu Ala Leu Arg Gln Ile Leu Arg Glu Ser Gly Gly Ile Asp Lys 
        115                 120                 125             


Glu Ala Met Gly Phe Thr Tyr Ser Gly Ile Arg Thr Asn Gly Ala Thr 
    130                 135                 140                 


Ser Ala Cys Arg Arg Ser Gly Ser Ser Phe Tyr Ala Glu Met Lys Trp 
145                 150                 155                 160 


Leu Leu Ser Asn Thr Asp Asn Ala Ala Phe Pro Gln Met Thr Lys Ser 
                165                 170                 175     


Tyr Lys Asn Thr Arg Lys Ser Pro Ala Leu Ile Val Trp Gly Ile His 
            180                 185                 190         


His Ser Val Ser Thr Ala Glu Gln Thr Lys Leu Tyr Gly Ser Gly Asn 
        195                 200                 205             


Lys Leu Val Thr Val Gly Ser Ser Asn Tyr Gln Gln Ser Phe Val Pro 
    210                 215                 220                 


Ser Pro Gly Ala Arg Pro Gln Val Asn Gly Ile Ser Gly Arg Ile Asp 
225                 230                 235                 240 


Phe His Trp Leu Met Leu Asn Pro Asn Asp Thr Val Thr Phe Ser Phe 
                245                 250                 255     


Asn Gly Ala Phe Ile Ala Pro Asp Arg Ala Ser Phe Leu Arg Gly Lys 
            260                 265                 270         


Ser Met Gly Ile Gln Ser Gly Val Gln Val Asp Ala Asn Cys Glu Gly 
        275                 280                 285             


Asp Cys Tyr His Ser Gly Gly Thr Ile Ile Ser Asn Leu Pro Phe Gln 
    290                 295                 300                 


Asn Ile Asp Ser Arg Ala Val Gly Lys Cys Pro Arg Tyr Val Lys Gln 
305                 310                 315                 320 


Arg Ser Leu Leu Leu Ala Thr Gly Met Lys Asn Val Pro Glu Ile Pro 
                325                 330                 335     


Lys Gly Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly 
            340                 345                 350         


Trp Glu Gly Leu Ile Asp Gly Trp Tyr Gly Phe Arg His Gln Asn Ala 
        355                 360                 365             


Gln Gly Glu Gly Thr Ala Ala Asp Tyr Lys Ser Thr Gln Ser Ala Ile 
    370                 375                 380                 


Asp Gln Ile Thr Gly Lys Leu Asn Arg Leu Ile Glu Lys Thr Asn Gln 
385                 390                 395                 400 


Gln Phe Glu Leu Ile Asp Asn Glu Phe Asn Glu Val Glu Lys Gln Ile 
                405                 410                 415     


Gly Asn Val Ile Asn Trp Thr Arg Asp Ser Ile Thr Glu Val Trp Ser 
            420                 425                 430         


Tyr Asn Ala Glu Leu Leu Val Ala Met Glu Asn Gln His Thr Ile Asp 
        435                 440                 445             


Leu Ala Asp Ser Glu Met Asp Lys Leu Tyr Glu Arg Val Lys Arg Gln 
    450                 455                 460                 


Leu Arg Glu Asn Ala Glu Glu Asp Gly Thr Gly Cys Phe Glu Ile Phe 
465                 470                 475                 480 


His Lys Cys Asp Asp Asp Cys Met Ala Ser Ile Arg Asn Asn Thr Tyr 
                485                 490                 495     


Asp His Ser Lys Tyr Arg Glu Glu Ala Met Gln Asn Arg Ile Gln Ile 
            500                 505                 510         


Asp Pro Val Lys Leu Ser Ser Gly Tyr Lys Asp Val Ile Leu Trp Phe 
        515                 520                 525             


Ser Phe Gly Ala Ser Cys Phe Ile Leu Leu Ala Ile Val Met Gly Leu 
    530                 535                 540                 


Val Phe Ile Cys Val Lys Asn Gly Asn Met Arg Cys Thr Ile Cys Ile 
545                 550                 555                 560 


<210>  80
<211>  469
<212>  PRT
<213>  Influenza A virus

<400>  80

Met Asn Pro Asn Gln Lys Ile Ile Thr Ile Gly Ser Ile Cys Met Ile 
1               5                   10                  15      


Val Gly Ile Ile Ser Leu Ile Leu Gln Ile Gly Asn Ile Ile Ser Ile 
            20                  25                  30          


Trp Val Ser His Ser Ile Gln Thr Gly Asn Gln Asn Gln Pro Glu Ile 
        35                  40                  45              


Cys Asn Gln Ser Ile Ile Thr Tyr Glu Asn Asn Thr Trp Val Asn Gln 
    50                  55                  60                  


Thr Tyr Val Asn Ile Ser Asn Thr Asn Phe Val Thr Glu Gln Ala Leu 
65                  70                  75                  80  


Ala Pro Val Ala Leu Ala Gly Asn Ser Ser Leu Cys Pro Ile Ser Gly 
                85                  90                  95      


Trp Ala Ile Tyr Ser Lys Asp Asn Gly Ile Arg Ile Gly Ser Lys Gly 
            100                 105                 110         


Asp Val Phe Val Ile Arg Glu Pro Phe Ile Ser Cys Ser His Leu Glu 
        115                 120                 125             


Cys Arg Thr Phe Phe Leu Thr Gln Gly Ala Leu Leu Asn Asp Lys His 
    130                 135                 140                 


Ser Asn Gly Thr Val Lys Asp Arg Ser Pro Tyr Arg Thr Leu Met Ser 
145                 150                 155                 160 


Cys Pro Ile Gly Glu Ser Pro Ser Pro Tyr Asn Ser Arg Phe Glu Ser 
                165                 170                 175     


Val Ala Trp Ser Ala Ser Ala Cys His Asp Gly Ile Gly Trp Leu Thr 
            180                 185                 190         


Ile Gly Ile Ser Gly Pro Asp Asn Gly Ala Val Ala Val Leu Lys Tyr 
        195                 200                 205             


Asn Gly Ile Ile Thr Asp Thr Ile Lys Ser Trp Arg Asn Asn Ile Leu 
    210                 215                 220                 


Arg Thr Gln Glu Ser Glu Cys Ala Cys Met Asn Gly Ser Cys Phe Thr 
225                 230                 235                 240 


Ile Met Thr Asp Gly Pro Ser Asn Gly Gln Ala Ser Tyr Lys Ile Phe 
                245                 250                 255     


Lys Ile Glu Lys Gly Lys Val Val Lys Ser Val Glu Leu Asn Ala Pro 
            260                 265                 270         


Asn Tyr His Tyr Glu Glu Cys Ser Cys Tyr Pro Asp Ala Gly Glu Ile 
        275                 280                 285             


Met Cys Val Cys Arg Asp Asn Trp His Gly Ser Asn Arg Pro Trp Val 
    290                 295                 300                 


Ser Phe Asn Gln Asn Leu Glu Tyr Gln Ile Gly Tyr Ile Cys Ser Gly 
305                 310                 315                 320 


Val Phe Gly Asp Asn Pro Arg Pro Asn Asp Gly Ala Gly Ser Cys Gly 
                325                 330                 335     


Pro Val Ser Ser Asn Gly Ala Tyr Gly Val Lys Gly Phe Ser Phe Lys 
            340                 345                 350         


Tyr Gly Lys Gly Val Trp Ile Gly Arg Thr Lys Ser Thr Ser Ser Arg 
        355                 360                 365             


Ser Gly Phe Glu Met Ile Trp Asp Pro Asn Gly Trp Thr Glu Thr Asp 
    370                 375                 380                 


Ser Ser Phe Ser Val Lys Gln Asp Ile Val Ala Ile Thr Asp Trp Ser 
385                 390                 395                 400 


Gly Tyr Ser Gly Ser Phe Val Gln His Pro Glu Leu Thr Gly Leu Asp 
                405                 410                 415     


Cys Met Arg Pro Cys Phe Trp Val Glu Leu Ile Arg Gly Arg Pro Lys 
            420                 425                 430         


Glu Asn Thr Ile Trp Thr Ser Gly Ser Ser Ile Ser Phe Cys Gly Val 
        435                 440                 445             


Asn Ser Asp Thr Val Gly Trp Ser Trp Pro Asp Gly Ala Glu Leu Pro 
    450                 455                 460                 


Phe Thr Ile Asp Lys 
465                 


<210>  81
<211>  607
<212>  PRT
<213>  Canine Distemper Virus

<400>  81

Met Leu Ser Tyr Gln Asp Lys Val Gly Ala Phe Tyr Lys Asp Asn Ala 
1               5                   10                  15      


Arg Ala Asn Ser Ser Lys Leu Ser Leu Val Thr Glu Glu Gln Gly Gly 
            20                  25                  30          


Arg Arg Pro Pro Tyr Leu Leu Phe Val Leu Leu Ile Leu Leu Val Gly 
        35                  40                  45              


Ile Met Ala Leu Leu Ala Ile Thr Gly Val Arg Phe His Gln Val Ser 
    50                  55                  60                  


Thr Ser Asn Met Glu Phe Ser Arg Leu Leu Lys Glu Asp Met Glu Lys 
65                  70                  75                  80  


Ser Glu Ala Val His His Gln Val Ile Asp Val Leu Thr Pro Leu Phe 
                85                  90                  95      


Lys Ile Ile Gly Asp Glu Val Gly Leu Arg Leu Pro Gln Lys Leu Asn 
            100                 105                 110         


Glu Ile Lys Gln Phe Ile Leu Gln Lys Thr Asn Phe Phe Asn Pro Asn 
        115                 120                 125             


Arg Glu Phe Asp Phe Arg Asp Leu His Trp Cys Ile Asn Pro Pro Ser 
    130                 135                 140                 


Lys Ile Lys Val Asn Phe Thr Asn Tyr Cys Asp Thr Ile Gly Ile Arg 
145                 150                 155                 160 


Lys Ser Ile Ala Ser Ala Ala Asn Pro Ile Leu Leu Ser Ala His Thr 
                165                 170                 175     


Gly Gly Arg Gly Asp Ile Phe Pro Pro Tyr Arg Cys Ser Gly Ala Thr 
            180                 185                 190         


Thr Ser Val Gly Arg Val Phe Pro Leu Ser Val Ser Leu Ser Met Ser 
        195                 200                 205             


Leu Ile Ser Arg Thr Ser Glu Ile Ile Asn Met Leu Thr Ala Ile Ser 
    210                 215                 220                 


Asp Gly Val Tyr Gly Lys Thr Tyr Leu Leu Val Pro Asp Tyr Ile Glu 
225                 230                 235                 240 


Gly Glu Phe Asp Thr Gln Lys Ile Arg Val Phe Glu Ile Gly Phe Ile 
                245                 250                 255     


Lys Arg Trp Leu Asn Asp Met Pro Leu Leu Gln Thr Thr Asn Tyr Met 
            260                 265                 270         


Val Leu Pro Glu Asn Ser Lys Ala Lys Val Cys Thr Ile Ala Val Gly 
        275                 280                 285             


Glu Leu Thr Leu Ala Ser Leu Cys Val Asp Glu Ser Thr Ile Leu Leu 
    290                 295                 300                 


Tyr His Asp Ser Asn Gly Ser Gln Asp Gly Ile Leu Val Val Thr Leu 
305                 310                 315                 320 


Gly Ile Phe Gly Ala Thr Pro Met Asp Gln Val Glu Glu Val Ile Pro 
                325                 330                 335     


Val Ala His Pro Ser Val Glu Lys Ile His Ile Thr Asn His Arg Gly 
            340                 345                 350         


Phe Ile Lys Asp Ser Ile Ala Thr Trp Met Val Pro Ala Leu Val Ser 
        355                 360                 365             


Glu Lys Gln Glu Glu Gln Lys Ser Cys Leu Glu Ser Ala Cys Gln Arg 
    370                 375                 380                 


Lys Ser Tyr Pro Met Cys Asn Gln Thr Ser Trp Glu Pro Phe Gly Gly 
385                 390                 395                 400 


Gly Gln Leu Pro Ser Tyr Gly Arg Leu Thr Leu Pro Leu Asp Pro Ser 
                405                 410                 415     


Ile Asp Leu Gln Leu Asn Ile Ser Phe Thr Tyr Gly Pro Val Ile Leu 
            420                 425                 430         


Asn Gly Asn Gly Met Asp Tyr Tyr Glu Ser Pro Leu Leu Gly Ser Gly 
        435                 440                 445             


Trp Leu Thr Ile Pro Pro Lys Asn Gly Thr Val Leu Gly Leu Ile Asn 
    450                 455                 460                 


Lys Ala Gly Arg Gly Asp Gln Phe Thr Val Ile Pro His Val Leu Thr 
465                 470                 475                 480 


Phe Ala Pro Arg Glu Ser Ser Gly Asn Cys Tyr Leu Pro Ile Gln Thr 
                485                 490                 495     


Ser Gln Ile Met Asp Lys Asp Val Leu Thr Glu Ser Asn Leu Val Val 
            500                 505                 510         


Leu Pro Thr Gln Asn Phe Arg Tyr Val Ile Ala Thr Tyr Asp Ile Ser 
        515                 520                 525             


Arg Gly Asp His Ala Ile Val Tyr Tyr Val Tyr Asp Pro Ile Arg Thr 
    530                 535                 540                 


Ile Ser Tyr Thr His Pro Phe Arg Leu Thr Thr Lys Gly Arg Pro Asp 
545                 550                 555                 560 


Phe Leu Arg Ile Glu Cys Phe Val Trp Asp Asp Asp Leu Trp Cys His 
                565                 570                 575     


Gln Phe Tyr Arg Phe Glu Thr Asp Ser Thr Asn Ser Thr Thr Ser Val 
            580                 585                 590         


Glu Asn Leu Val Arg Ile Arg Phe Ser Cys Ser Arg Ser Lys Pro 
        595                 600                 605         


<210>  82
<211>  511
<212>  PRT
<213>  Vesicular stomatitis Alagoas virus

<400>  82

Met Thr Pro Ala Phe Ile Leu Cys Met Leu Leu Ala Gly Ser Ser Trp 
1               5                   10                  15      


Ala Lys Phe Thr Ile Val Phe Pro Gln Ser Gln Lys Gly Asp Trp Lys 
            20                  25                  30          


Asp Val Pro Pro Asn Tyr Arg Tyr Cys Pro Ser Ser Ala Asp Gln Asn 
        35                  40                  45              


Trp His Gly Asp Leu Leu Gly Val Asn Ile Arg Ala Lys Met Pro Lys 
    50                  55                  60                  


Val His Lys Ala Ile Lys Ala Asp Gly Trp Met Cys His Ala Ala Lys 
65                  70                  75                  80  


Trp Val Thr Thr Cys Asp Tyr Arg Trp Tyr Gly Pro Gln Tyr Ile Thr 
                85                  90                  95      


His Ser Ile His Ser Phe Ile Pro Thr Lys Ala Gln Cys Glu Glu Ser 
            100                 105                 110         


Ile Lys Gln Thr Lys Glu Gly Val Trp Ile Asn Pro Gly Phe Pro Pro 
        115                 120                 125             


Lys Asn Cys Gly Tyr Ala Ser Val Ser Asp Ala Glu Ser Ile Ile Val 
    130                 135                 140                 


Gln Ala Thr Ala His Ser Val Met Ile Asp Glu Tyr Ser Gly Asp Trp 
145                 150                 155                 160 


Leu Asp Ser Gln Phe Pro Thr Gly Arg Cys Thr Gly Ser Thr Cys Glu 
                165                 170                 175     


Thr Ile His Asn Ser Thr Leu Trp Tyr Ala Asp Tyr Gln Val Thr Gly 
            180                 185                 190         


Leu Cys Asp Ser Ala Leu Val Ser Thr Glu Val Thr Phe Tyr Ser Glu 
        195                 200                 205             


Asp Gly Leu Met Thr Ser Ile Gly Arg Gln Asn Thr Gly Tyr Arg Ser 
    210                 215                 220                 


Asn Tyr Phe Pro Tyr Glu Lys Gly Ala Ala Ala Cys Arg Met Lys Tyr 
225                 230                 235                 240 


Cys Thr His Glu Gly Ile Arg Leu Pro Ser Gly Val Trp Phe Glu Met 
                245                 250                 255     


Val Asp Lys Glu Leu Leu Glu Ser Val Gln Met Pro Glu Cys Pro Ala 
            260                 265                 270         


Gly Leu Thr Ile Ser Ala Pro Thr Gln Thr Ser Val Asp Val Ser Leu 
        275                 280                 285             


Ile Leu Asp Val Glu Arg Met Leu Asp Tyr Ser Leu Cys Gln Glu Thr 
    290                 295                 300                 


Trp Ser Lys Val His Ser Gly Leu Pro Ile Ser Pro Val Asp Leu Gly 
305                 310                 315                 320 


Tyr Ile Ala Pro Lys Asn Pro Gly Ala Gly Pro Ala Phe Thr Ile Val 
                325                 330                 335     


Asn Gly Thr Leu Lys Tyr Phe Asp Thr Arg Tyr Leu Arg Ile Asp Ile 
            340                 345                 350         


Glu Gly Pro Val Leu Lys Lys Met Thr Gly Lys Val Ser Gly Thr Pro 
        355                 360                 365             


Thr Lys Arg Glu Leu Trp Thr Glu Trp Phe Pro Tyr Asp Asp Val Glu 
    370                 375                 380                 


Ile Gly Pro Asn Gly Val Leu Lys Thr Pro Glu Gly Tyr Lys Phe Pro 
385                 390                 395                 400 


Leu Tyr Met Ile Gly His Gly Leu Leu Asp Ser Asp Leu Gln Lys Thr 
                405                 410                 415     


Ser Gln Ala Glu Val Phe His His Pro Gln Ile Ala Glu Ala Val Gln 
            420                 425                 430         


Lys Leu Pro Asp Asp Glu Thr Leu Phe Phe Gly Asp Thr Gly Ile Ser 
        435                 440                 445             


Lys Asn Pro Val Glu Val Ile Glu Gly Trp Phe Ser Asn Trp Arg Ser 
    450                 455                 460                 


Ser Val Met Ala Ile Val Phe Ala Ile Leu Leu Leu Val Ile Thr Val 
465                 470                 475                 480 


Leu Met Val Arg Leu Cys Val Ala Phe Arg His Phe Cys Cys Gln Lys 
                485                 490                 495     


Arg His Lys Ile Tyr Asn Asp Leu Glu Met Asn Gln Leu Arg Arg 
            500                 505                 510     


<210>  83
<211>  505
<212>  PRT
<213>  American bat vesiculovirus

<400>  83

Met Val Arg Ile Ile Cys Trp Leu Gly Leu Val Leu Ser Val Gln Ala 
1               5                   10                  15      


Ala Lys Val Ile Leu Pro Val Lys Leu Glu Ser Asp Trp Val Pro Val 
            20                  25                  30          


Tyr Ser Gly Glu Arg Ile Cys Gln Ser His Arg Glu Lys Ile Pro Pro 
        35                  40                  45              


Gly Ile Tyr Glu Ser Leu Lys Val Glu Gly Gln Val Pro Val Arg Gln 
    50                  55                  60                  


Gln Ser Gln Gly Ala Asp Gly Tyr Tyr Cys His Lys Thr Ile Tyr Ser 
65                  70                  75                  80  


Val Leu Cys Asp Phe Lys Trp Tyr Gly Val Lys Arg Val Arg His Ser 
                85                  90                  95      


Val Lys Arg Asp Thr Pro Ser Tyr Ser Glu Cys Leu Lys Ala Val Asp 
            100                 105                 110         


Asp Glu Ile Ser Gly Met Ser Glu Tyr Val Gly Phe Pro Pro Pro Ser 
        115                 120                 125             


Cys Asn Tyr Leu Val Glu Thr Arg Ser Gln Asn Ile Glu Ile Ile Leu 
    130                 135                 140                 


Ser Lys His Ser Val Lys Ile Asp Asp Tyr Lys Gln Ser Trp Met Asp 
145                 150                 155                 160 


Ser Thr Phe Leu Asp Gly Gly Cys Ser His Ala Pro Cys Leu Thr Thr 
                165                 170                 175     


Val Pro Gly Thr Leu Trp Ile Pro Thr Asp Asn Leu Thr Ser Ala Cys 
            180                 185                 190         


Asp Ile Thr Phe Arg Lys Gln Glu Phe Thr Ile Tyr Tyr Pro Lys Gln 
        195                 200                 205             


Lys Pro Ala His Leu Ser Ser Asp Gln Ile Phe Ile Thr Ser Pro Tyr 
    210                 215                 220                 


His Pro Val Ser Ser Leu Ser Lys Ser Cys Leu Ile Thr Leu Cys Gly 
225                 230                 235                 240 


Lys Thr Gly Ile Arg Leu Pro Gly Gly Ser Trp Ser Ser Leu Asp Asn 
                245                 250                 255     


His Lys Ser Phe His Asp Ile Lys Ile Glu Thr Leu Leu Ser Asn Cys 
            260                 265                 270         


Lys Ser Ser Thr Glu Ile Tyr Ser Ser Pro Pro Asp Leu Arg Asn Ile 
        275                 280                 285             


Arg Met Val Trp Asp Leu Glu Arg Val Ile Glu Asn Ser Leu Cys Gln 
    290                 295                 300                 


Gly Thr Trp Asp Lys Ile Glu Thr Arg Gln Lys Ile Thr Pro Leu Asp 
305                 310                 315                 320 


Leu Asn Tyr Leu Ser Pro Ser Glu Pro Gly Pro Gly Trp Gly Phe Ile 
                325                 330                 335     


Pro Lys Asn Gly Ser Ile His Lys Ala Gln Ile Leu Tyr Ile Arg Ala 
            340                 345                 350         


Asp Val Asp Asp Asp Thr Ile Ala Leu Gly Gln Lys Tyr Asn Lys Gly 
        355                 360                 365             


Lys Asp Glu Phe Tyr Phe Asn Trp Asn Asp Trp Glu Leu Leu Asn Gly 
    370                 375                 380                 


Ile Lys Ile Gly Pro Asn Gly Ile Ile Thr Asn Thr His Val Arg Ile 
385                 390                 395                 400 


Pro Tyr Tyr Ser Val Gly Ile Gly Lys Leu Asp Glu Asp Met Ile Thr 
                405                 410                 415     


Pro Asp Glu Val Gly Val Ile His His Ile Asp His Leu Lys Gln Arg 
            420                 425                 430         


Val Leu Val Gln Thr Asn Leu Asp Arg Val Trp Ile His Glu Gly Glu 
        435                 440                 445             


Asn Gly Asp Leu Ile Thr Ser Val Ser His Trp Trp His Asp Val Ile 
    450                 455                 460                 


Lys His Ser Trp Glu Ile Phe Ala Leu Ile Gly Gly Leu Phe Ser Leu 
465                 470                 475                 480 


Ser Cys Ile Cys Ser Leu Cys Ser Cys Arg Lys Lys Arg Arg Glu Ser 
                485                 490                 495     


Arg His Gln Glu Thr Met Ser Phe Val 
            500                 505 


<210>  84
<211>  523
<212>  PRT
<213>  Carajas vesiculovirus

<400>  84

Met Lys Met Lys Met Val Ile Ala Gly Leu Ile Leu Cys Ile Gly Ile 
1               5                   10                  15      


Leu Pro Ala Ile Gly Lys Ile Thr Ile Ser Phe Pro Gln Ser Leu Lys 
            20                  25                  30          


Gly Asp Trp Arg Pro Val Pro Lys Gly Tyr Asn Tyr Cys Pro Thr Ser 
        35                  40                  45              


Ala Asp Lys Asn Leu His Gly Asp Leu Ile Asp Ile Gly Leu Arg Leu 
    50                  55                  60                  


Arg Ala Pro Lys Ser Phe Lys Gly Ile Ser Ala Asp Gly Trp Met Cys 
65                  70                  75                  80  


His Ala Ala Arg Trp Ile Thr Thr Cys Asp Phe Arg Trp Tyr Gly Pro 
                85                  90                  95      


Lys Tyr Ile Thr His Ser Ile His Ser Phe Arg Pro Ser Asn Asp Gln 
            100                 105                 110         


Cys Lys Glu Ala Ile Arg Leu Thr Asn Glu Gly Asn Trp Ile Asn Pro 
        115                 120                 125             


Gly Phe Pro Pro Gln Ser Cys Gly Tyr Ala Ser Val Thr Asp Ser Glu 
    130                 135                 140                 


Ser Val Val Val Thr Val Thr Lys His Gln Val Leu Val Asp Glu Tyr 
145                 150                 155                 160 


Ser Gly Ser Trp Ile Asp Ser Gln Phe Pro Gly Gly Ser Cys Thr Ser 
                165                 170                 175     


Pro Ile Cys Asp Thr Val His Asn Ser Thr Leu Trp His Ala Asp His 
            180                 185                 190         


Thr Leu Asp Ser Ile Cys Asp Gln Glu Phe Val Ala Met Asp Ala Val 
        195                 200                 205             


Leu Phe Thr Glu Ser Gly Lys Phe Glu Glu Phe Gly Lys Pro Asn Ser 
    210                 215                 220                 


Gly Ile Arg Ser Asn Tyr Phe Pro Tyr Glu Ser Leu Lys Asp Val Cys 
225                 230                 235                 240 


Gln Met Asp Phe Cys Lys Arg Lys Gly Phe Lys Leu Pro Ser Gly Val 
                245                 250                 255     


Trp Phe Glu Ile Glu Asp Ala Glu Lys Ser His Lys Ala Gln Val Glu 
            260                 265                 270         


Leu Lys Ile Lys Arg Cys Pro His Gly Ala Val Ile Ser Ala Pro Asn 
        275                 280                 285             


Gln Asn Ala Ala Asp Ile Asn Leu Ile Met Asp Val Glu Arg Ile Leu 
    290                 295                 300                 


Asp Tyr Ser Leu Cys Gln Ala Thr Trp Ser Lys Ile Gln Asn Lys Glu 
305                 310                 315                 320 


Ala Leu Thr Pro Ile Asp Ile Ser Tyr Leu Gly Pro Lys Asn Pro Gly 
                325                 330                 335     


Pro Gly Pro Ala Phe Thr Ile Ile Asn Gly Thr Leu His Tyr Phe Asn 
            340                 345                 350         


Thr Arg Tyr Ile Arg Val Asp Ile Ala Gly Pro Val Thr Lys Glu Ile 
        355                 360                 365             


Thr Gly Phe Val Ser Gly Thr Ser Thr Ser Arg Val Leu Trp Asp Gln 
    370                 375                 380                 


Trp Phe Pro Tyr Gly Glu Asn Ser Ile Gly Pro Asn Gly Leu Leu Lys 
385                 390                 395                 400 


Thr Ala Ser Gly Tyr Lys Tyr Pro Leu Phe Met Val Gly Thr Gly Val 
                405                 410                 415     


Leu Asp Ala Asp Ile His Lys Leu Gly Glu Ala Thr Val Ile Glu His 
            420                 425                 430         


Pro His Ala Lys Glu Ala Gln Lys Val Val Asp Asp Ser Glu Val Ile 
        435                 440                 445             


Phe Phe Gly Asp Thr Gly Val Ser Lys Asn Pro Val Glu Val Val Glu 
    450                 455                 460                 


Gly Trp Phe Ser Gly Trp Arg Ser Ser Leu Met Ser Ile Phe Gly Ile 
465                 470                 475                 480 


Ile Leu Leu Ile Val Cys Leu Val Leu Ile Val Arg Ile Leu Ile Ala 
                485                 490                 495     


Leu Lys Tyr Cys Cys Val Arg His Lys Lys Arg Thr Ile Tyr Lys Glu 
            500                 505                 510         


Asp Leu Glu Met Gly Arg Ile Pro Arg Arg Ala 
        515                 520             


<210>  85
<211>  530
<212>  PRT
<213>  Chandipura vesiculovirus

<400>  85

Met Thr Ser Ser Val Thr Ile Ser Val Ile Leu Leu Ile Ser Phe Ile 
1               5                   10                  15      


Ala Pro Ser Tyr Ser Ser Leu Ser Ile Ala Phe Pro Glu Asn Thr Lys 
            20                  25                  30          


Leu Asp Trp Lys Pro Val Thr Lys Asn Thr Arg Tyr Cys Pro Met Gly 
        35                  40                  45              


Gly Glu Trp Phe Leu Glu Pro Gly Leu Gln Glu Glu Ser Phe Leu Ser 
    50                  55                  60                  


Ser Thr Pro Ile Gly Ala Thr Pro Ser Lys Ser Asp Gly Phe Leu Cys 
65                  70                  75                  80  


His Ala Ala Lys Trp Val Thr Thr Cys Asp Phe Arg Trp Tyr Gly Pro 
                85                  90                  95      


Lys Tyr Ile Thr His Ser Ile His Asn Ile Lys Pro Thr Arg Ser Asp 
            100                 105                 110         


Cys Asp Thr Ala Leu Ala Ser Tyr Lys Ser Gly Thr Leu Val Ser Pro 
        115                 120                 125             


Gly Phe Pro Pro Glu Ser Cys Gly Tyr Ala Ser Val Thr Asp Ser Glu 
    130                 135                 140                 


Phe Leu Val Ile Met Ile Thr Pro His His Val Gly Val Asp Asp Tyr 
145                 150                 155                 160 


Arg Gly His Trp Val Asp Pro Leu Phe Val Gly Gly Glu Cys Asp Gln 
                165                 170                 175     


Ser Tyr Cys Asp Thr Ile His Asn Ser Ser Val Trp Ile Pro Ala Asp 
            180                 185                 190         


Gln Thr Lys Lys Asn Ile Cys Gly Gln Ser Phe Thr Pro Leu Thr Val 
        195                 200                 205             


Thr Val Ala Tyr Asp Lys Thr Lys Glu Ile Ala Ala Gly Ala Ile Val 
    210                 215                 220                 


Phe Lys Ser Lys Tyr His Ser His Met Glu Gly Ala Arg Thr Cys Arg 
225                 230                 235                 240 


Leu Ser Tyr Cys Gly Arg Asn Gly Ile Lys Phe Pro Asn Gly Glu Trp 
                245                 250                 255     


Val Ser Leu Asp Val Lys Thr Lys Ile Gln Glu Lys Pro Leu Leu Pro 
            260                 265                 270         


Leu Phe Lys Glu Cys Pro Ala Gly Thr Glu Val Arg Ser Thr Leu Gln 
        275                 280                 285             


Ser Asp Gly Ala Gln Val Leu Thr Ser Glu Ile Gln Arg Ile Leu Asp 
    290                 295                 300                 


Tyr Ser Leu Cys Gln Asn Thr Trp Asp Lys Val Glu Arg Lys Glu Pro 
305                 310                 315                 320 


Leu Ser Pro Leu Asp Leu Ser Tyr Leu Ala Ser Lys Ser Pro Gly Lys 
                325                 330                 335     


Gly Leu Ala Tyr Thr Val Ile Asn Gly Thr Leu Ser Phe Ala His Thr 
            340                 345                 350         


Arg Tyr Val Arg Met Trp Ile Asp Gly Pro Val Leu Lys Glu Met Lys 
        355                 360                 365             


Gly Lys Arg Glu Ser Pro Ser Gly Ile Ser Ser Asp Ile Trp Thr Gln 
    370                 375                 380                 


Trp Phe Lys Tyr Gly Asp Met Glu Ile Gly Pro Asn Gly Leu Leu Lys 
385                 390                 395                 400 


Thr Ala Gly Gly Tyr Lys Phe Pro Trp His Leu Ile Gly Met Gly Ile 
                405                 410                 415     


Val Asp Asn Glu Leu His Glu Leu Ser Glu Ala Asn Pro Leu Asp His 
            420                 425                 430         


Pro Gln Leu Pro His Ala Gln Ser Ile Ala Asp Asp Ser Glu Glu Ile 
        435                 440                 445             


Phe Phe Gly Asp Thr Gly Val Ser Lys Asn Pro Val Glu Leu Val Thr 
    450                 455                 460                 


Gly Trp Phe Thr Ser Trp Lys Glu Ser Leu Ala Ala Gly Val Val Leu 
465                 470                 475                 480 


Ile Leu Val Val Val Leu Ile Tyr Gly Val Leu Arg Cys Phe Pro Val 
                485                 490                 495     


Leu Cys Thr Thr Cys Arg Lys Pro Lys Trp Lys Lys Gly Val Glu Arg 
            500                 505                 510         


Ser Asp Ser Phe Glu Met Arg Ile Phe Lys Pro Asn Asn Met Arg Ala 
        515                 520                 525             


Arg Val 
    530 


<210>  86
<211>  512
<212>  PRT
<213>  Cocal vesiculovirus

<400>  86

Met Asn Phe Leu Leu Leu Thr Phe Ile Val Leu Pro Leu Cys Ser His 
1               5                   10                  15      


Ala Lys Phe Ser Ile Val Phe Pro Gln Ser Gln Lys Gly Asn Trp Lys 
            20                  25                  30          


Asn Val Pro Ser Ser Tyr His Tyr Cys Pro Ser Ser Ser Asp Gln Asn 
        35                  40                  45              


Trp His Asn Asp Leu Leu Gly Ile Thr Met Lys Val Lys Met Pro Lys 
    50                  55                  60                  


Thr His Lys Ala Ile Gln Ala Asp Gly Trp Met Cys His Ala Ala Lys 
65                  70                  75                  80  


Trp Ile Thr Thr Cys Asp Phe Arg Trp Tyr Gly Pro Lys Tyr Ile Thr 
                85                  90                  95      


His Ser Ile His Ser Ile Gln Pro Thr Ser Glu Gln Cys Lys Glu Ser 
            100                 105                 110         


Ile Lys Gln Thr Lys Gln Gly Thr Trp Met Ser Pro Gly Phe Pro Pro 
        115                 120                 125             


Gln Asn Cys Gly Tyr Ala Thr Val Thr Asp Ser Val Ala Val Val Val 
    130                 135                 140                 


Gln Ala Thr Pro His His Val Leu Val Asp Glu Tyr Thr Gly Glu Trp 
145                 150                 155                 160 


Ile Asp Ser Gln Phe Pro Asn Gly Lys Cys Glu Thr Glu Glu Cys Glu 
                165                 170                 175     


Thr Val His Asn Ser Thr Val Trp Tyr Ser Asp Tyr Lys Val Thr Gly 
            180                 185                 190         


Leu Cys Asp Ala Thr Leu Val Asp Thr Glu Ile Thr Phe Phe Ser Glu 
        195                 200                 205             


Asp Gly Lys Lys Glu Ser Ile Gly Lys Pro Asn Thr Gly Tyr Arg Ser 
    210                 215                 220                 


Asn Tyr Phe Ala Tyr Glu Lys Gly Asp Lys Val Cys Lys Met Asn Tyr 
225                 230                 235                 240 


Cys Lys His Ala Gly Val Arg Leu Pro Ser Gly Val Trp Phe Glu Phe 
                245                 250                 255     


Val Asp Gln Asp Val Tyr Ala Ala Ala Lys Leu Pro Glu Cys Pro Val 
            260                 265                 270         


Gly Ala Thr Ile Ser Ala Pro Thr Gln Thr Ser Val Asp Val Ser Leu 
        275                 280                 285             


Ile Leu Asp Val Glu Arg Ile Leu Asp Tyr Ser Leu Cys Gln Glu Thr 
    290                 295                 300                 


Trp Ser Lys Ile Arg Ser Lys Gln Pro Val Ser Pro Val Asp Leu Ser 
305                 310                 315                 320 


Tyr Leu Ala Pro Lys Asn Pro Gly Thr Gly Pro Ala Phe Thr Ile Ile 
                325                 330                 335     


Asn Gly Thr Leu Lys Tyr Phe Glu Thr Arg Tyr Ile Arg Ile Asp Ile 
            340                 345                 350         


Asp Asn Pro Ile Ile Ser Lys Met Val Gly Lys Ile Ser Gly Ser Gln 
        355                 360                 365             


Thr Glu Arg Glu Leu Trp Thr Glu Trp Phe Pro Tyr Glu Gly Val Glu 
    370                 375                 380                 


Ile Gly Pro Asn Gly Ile Leu Lys Thr Pro Thr Gly Tyr Lys Phe Pro 
385                 390                 395                 400 


Leu Phe Met Ile Gly His Gly Met Leu Asp Ser Asp Leu His Lys Thr 
                405                 410                 415     


Ser Gln Ala Glu Val Phe Glu His Pro His Leu Ala Glu Ala Pro Lys 
            420                 425                 430         


Gln Leu Pro Glu Glu Glu Thr Leu Phe Phe Gly Asp Thr Gly Ile Ser 
        435                 440                 445             


Lys Asn Pro Val Glu Leu Ile Glu Gly Trp Phe Ser Ser Trp Lys Ser 
    450                 455                 460                 


Thr Val Val Thr Phe Phe Phe Ala Ile Gly Val Phe Ile Leu Leu Tyr 
465                 470                 475                 480 


Val Val Ala Arg Ile Val Ile Ala Val Arg Tyr Arg Tyr Gln Gly Ser 
                485                 490                 495     


Asn Asn Lys Arg Ile Tyr Asn Asp Ile Glu Met Ser Arg Phe Arg Lys 
            500                 505                 510         


<210>  87
<211>  511
<212>  PRT
<213>  Indiana vesiculovirus

<400>  87

Met Lys Cys Leu Leu Tyr Leu Ala Phe Leu Ser Ile Gly Val Asn Cys 
1               5                   10                  15      


Lys Phe Thr Ile Val Phe Pro His Asn Gln Lys Gly Thr Trp Lys Asn 
            20                  25                  30          


Val Pro Ser Asn Tyr His Tyr Cys Pro Ser Ser Ser Asp Leu Asn Trp 
        35                  40                  45              


His Asn Asp Leu Ile Gly Thr Ala Leu Gln Val Lys Met Pro Lys Ser 
    50                  55                  60                  


His Lys Ala Ile Gln Ala Asp Gly Trp Met Cys His Ala Ser Lys Trp 
65                  70                  75                  80  


Val Thr Thr Cys Asp Phe Arg Trp Tyr Gly Pro Lys Tyr Ile Thr His 
                85                  90                  95      


Ser Ile Arg Ser Phe Thr Pro Ser Val Glu Gln Cys Arg Glu Ser Ile 
            100                 105                 110         


Glu Gln Thr Lys Gln Gly Thr Trp Leu Asn Pro Gly Phe Pro Pro Gln 
        115                 120                 125             


Ser Cys Gly Tyr Ala Thr Val Thr Asp Ala Glu Ala Val Ile Val Gln 
    130                 135                 140                 


Val Thr Pro His His Val Leu Val Asp Glu Tyr Thr Gly Glu Trp Val 
145                 150                 155                 160 


Asp Ser Gln Phe Ile Asn Gly Lys Cys Ser Asn Asp Ile Cys Pro Thr 
                165                 170                 175     


Val His Asn Ser Thr Thr Trp His Ser Asp Tyr Lys Val Lys Gly Leu 
            180                 185                 190         


Cys Asp Ser Asn Leu Ile Ser Met Asp Ile Thr Phe Phe Ser Glu Asp 
        195                 200                 205             


Gly Glu Leu Ser Ser Leu Gly Lys Glu Gly Thr Gly Phe Arg Ser Asn 
    210                 215                 220                 


His Phe Ala Tyr Glu Thr Gly Asp Lys Ala Cys Lys Met Gln Tyr Cys 
225                 230                 235                 240 


Lys His Trp Gly Val Arg Leu Pro Ser Gly Val Trp Phe Glu Met Ala 
                245                 250                 255     


Asp Gln Asp Leu Phe Ala Ala Ala Arg Phe Pro Glu Cys Pro Glu Gly 
            260                 265                 270         


Ser Ser Ile Ser Ala Pro Ser Gln Thr Ser Val Asp Val Ser Leu Ile 
        275                 280                 285             


Gln Asp Val Glu Arg Ile Leu Asp Tyr Ser Leu Cys Gln Glu Thr Trp 
    290                 295                 300                 


Ser Lys Ile Gly Ala Gly Leu Pro Ile Ser Pro Val Asp Leu Ser Tyr 
305                 310                 315                 320 


Leu Ala Pro Lys Asn Pro Gly Thr Gly Pro Ala Phe Thr Ile Ile Asn 
                325                 330                 335     


Gly Thr Leu Lys Tyr Phe Glu Thr Arg Tyr Ile Arg Val Asp Ile Ala 
            340                 345                 350         


Ala Pro Ile Leu Ser Arg Met Val Gly Met Ile Ser Gly Thr Thr Thr 
        355                 360                 365             


Glu Arg Glu Leu Trp Asp Asp Trp Ala Pro Tyr Glu Asp Val Glu Ile 
    370                 375                 380                 


Gly Pro Asn Gly Val Leu Arg Thr Ser Ser Gly Tyr Lys Phe Pro Leu 
385                 390                 395                 400 


Tyr Met Ile Gly His Gly Met Leu Asp Ser Asp Leu His Leu Ser Ser 
                405                 410                 415     


Lys Ala Gln Val Phe Glu His Pro His Ile Gln Asp Ala Ala Ser Gln 
            420                 425                 430         


Leu Pro Asp Asp Glu Thr Leu Phe Phe Gly Asp Thr Gly Leu Ser Lys 
        435                 440                 445             


Asn Pro Ile Glu Leu Val Glu Gly Trp Phe Ser Gly Trp Lys Ser Ser 
    450                 455                 460                 


Ile Ala Ser Phe Phe Phe Ile Ile Gly Leu Ile Ile Gly Leu Phe Leu 
465                 470                 475                 480 


Val Leu Arg Val Gly Ile Tyr Leu Cys Ile Lys Leu Lys His Thr Lys 
                485                 490                 495     


Lys Arg Gln Ile Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Lys 
            500                 505                 510     


<210>  88
<211>  523
<212>  PRT
<213>  Isfahan vesiculovirus

<400>  88

Met Thr Ser Val Leu Phe Met Val Gly Val Leu Leu Gly Ala Phe Gly 
1               5                   10                  15      


Ser Thr His Cys Ser Ile Gln Ile Val Phe Pro Ser Glu Thr Lys Leu 
            20                  25                  30          


Val Trp Lys Pro Val Leu Lys Gly Thr Arg Tyr Cys Pro Gln Ser Ala 
        35                  40                  45              


Glu Leu Asn Leu Glu Pro Asp Leu Lys Thr Met Ala Phe Asp Ser Lys 
    50                  55                  60                  


Val Pro Ile Gly Ile Thr Pro Ser Asn Ser Asp Gly Tyr Leu Cys His 
65                  70                  75                  80  


Ala Ala Lys Trp Val Thr Thr Cys Asp Phe Arg Trp Tyr Gly Pro Lys 
                85                  90                  95      


Tyr Ile Thr His Ser Val His Ser Leu Arg Pro Thr Val Ser Asp Cys 
            100                 105                 110         


Lys Ala Ala Val Glu Ala Tyr Asn Ala Gly Thr Leu Met Tyr Pro Gly 
        115                 120                 125             


Phe Pro Pro Glu Ser Cys Gly Tyr Ala Ser Ile Thr Asp Ser Glu Phe 
    130                 135                 140                 


Tyr Val Met Leu Val Thr Pro His Pro Val Gly Val Asp Asp Tyr Arg 
145                 150                 155                 160 


Gly His Trp Val Asp Pro Leu Phe Pro Thr Ser Glu Cys Asn Ser Asn 
                165                 170                 175     


Phe Cys Glu Thr Val His Asn Ala Thr Met Trp Ile Pro Lys Asp Leu 
            180                 185                 190         


Lys Thr His Asp Val Cys Ser Gln Asp Phe Gln Thr Ile Arg Val Ser 
        195                 200                 205             


Val Met Tyr Pro Gln Thr Lys Pro Thr Lys Gly Ala Asp Leu Thr Leu 
    210                 215                 220                 


Lys Ser Lys Phe His Ala His Met Lys Gly Asp Arg Val Cys Lys Met 
225                 230                 235                 240 


Lys Phe Cys Asn Lys Asn Gly Leu Arg Leu Gly Asn Gly Glu Trp Ile 
                245                 250                 255     


Glu Val Gly Asp Glu Val Met Leu Asp Asn Ser Lys Leu Leu Ser Leu 
            260                 265                 270         


Phe Pro Asp Cys Leu Val Gly Ser Val Val Lys Ser Thr Leu Leu Ser 
        275                 280                 285             


Glu Gly Val Gln Thr Ala Leu Trp Glu Thr Asp Arg Leu Leu Asp Tyr 
    290                 295                 300                 


Ser Leu Cys Gln Asn Thr Trp Glu Lys Ile Asp Arg Lys Glu Pro Leu 
305                 310                 315                 320 


Ser Ala Val Asp Leu Ser Tyr Leu Ala Pro Arg Ser Pro Gly Lys Gly 
                325                 330                 335     


Met Ala Tyr Ile Val Ala Asn Gly Ser Leu Met Ser Ala Pro Ala Arg 
            340                 345                 350         


Tyr Ile Arg Val Trp Ile Asp Ser Pro Ile Leu Lys Glu Ile Lys Gly 
        355                 360                 365             


Lys Lys Glu Ser Ala Ser Gly Ile Asp Thr Val Leu Trp Glu Gln Trp 
    370                 375                 380                 


Leu Pro Phe Asn Gly Met Glu Leu Gly Pro Asn Gly Leu Ile Lys Thr 
385                 390                 395                 400 


Lys Ser Gly Tyr Lys Phe Pro Leu Tyr Leu Leu Gly Met Gly Ile Val 
                405                 410                 415     


Asp Gln Asp Leu Gln Glu Leu Ser Ser Val Asn Pro Val Asp His Pro 
            420                 425                 430         


His Val Pro Ile Ala Gln Ala Phe Val Ser Glu Gly Glu Glu Val Phe 
        435                 440                 445             


Phe Gly Asp Thr Gly Val Ser Lys Asn Pro Ile Glu Leu Ile Ser Gly 
    450                 455                 460                 


Trp Phe Ser Asp Trp Lys Glu Thr Ala Ala Ala Leu Gly Phe Ala Ala 
465                 470                 475                 480 


Ile Ser Val Ile Leu Ile Ile Gly Leu Met Arg Leu Leu Pro Leu Leu 
                485                 490                 495     


Cys Arg Arg Arg Lys Gln Lys Lys Val Ile Tyr Lys Asp Val Glu Leu 
            500                 505                 510         


Asn Ser Phe Asp Pro Arg Gln Ala Phe His Arg 
        515                 520             


<210>  89
<211>  524
<212>  PRT
<213>  Jurona vesiculovirus

<400>  89

Met Glu Ser Leu Pro Phe Ser Ala Leu Leu Ala Val Leu Ser Ile Thr 
1               5                   10                  15      


Leu Cys Asp Ser Ala Ile Pro Ile Phe Phe Pro Ser Glu Pro Gln Leu 
            20                  25                  30          


Glu Trp Lys Pro Val Leu Pro Gly Ser Arg Tyr Cys Pro Gln Ser Asn 
        35                  40                  45              


Glu Met Ser Leu Asp Pro Asp Leu Lys Lys Ser Thr Ile Ser Val Lys 
    50                  55                  60                  


Val Pro Ile Gly Val Thr Pro Ser Lys Ser Asp Gly Tyr Leu Cys His 
65                  70                  75                  80  


Gly Ala Lys Trp Val Ser Thr Cys Asp Phe Arg Trp Tyr Gly Pro Lys 
                85                  90                  95      


Tyr Ile Thr His Ser Ile His Asn Leu Arg Pro Thr Thr Asn Asp Cys 
            100                 105                 110         


Glu Asp Ala Ile Lys Lys Tyr Glu Ala Gly Thr Leu Ile Asn Pro Gly 
        115                 120                 125             


Phe Pro Pro Asp Ser Cys Ala Tyr Ala Thr Val Thr Asp Ser Glu His 
    130                 135                 140                 


Leu Val Ile Leu Ile Thr Pro His His Val Gly Val Asp Asp Tyr Arg 
145                 150                 155                 160 


Gly Ala Trp Val Asp Asp Ser Phe Pro Ser Gly Val Cys Glu Thr Asn 
                165                 170                 175     


Gln Cys Asp Thr Thr His Asn Ser Ser Ile Trp Ile Pro Lys Thr Lys 
            180                 185                 190         


Thr Arg His Asn Ile Cys Ser Gln Thr Phe Ala Asn Leu Ser Val Thr 
        195                 200                 205             


Ile Ser Tyr Arg Glu Gly Gly Ala Met Lys Gly Ala Asp Met Val Phe 
    210                 215                 220                 


His Ser Lys Tyr His Pro His Met Val Gly Gly His Ile Cys Lys Met 
225                 230                 235                 240 


Asn Phe Cys Asn Lys Gln Gly Leu Arg Leu Gln Asn Glu Glu Trp Ile 
                245                 250                 255     


Glu Ile Pro Ser Gly Thr Lys Val Gly Asn Gln Asp Leu Met Asn Leu 
            260                 265                 270         


Phe Ser Asp Cys Lys Ser Gly Leu Glu Val Arg Ser Thr Leu Arg Ser 
        275                 280                 285             


Glu Gly Ala Asn Thr Leu Thr Trp Glu Thr Gln Arg Leu Leu Asp Tyr 
    290                 295                 300                 


Ala Leu Cys Gln Asn Thr Trp Asp Lys Phe Asp Asn Gln Gly Ala Val 
305                 310                 315                 320 


Ser Ala Leu Asp Leu Ser Tyr Leu Ala Ala Arg Ala Pro Gly Lys Gly 
                325                 330                 335     


Val Ala Tyr Thr Met Ile Asn Gly Thr Leu His Ser Ala Pro Thr Arg 
            340                 345                 350         


Tyr Val Arg Met Trp Ile Glu Ser Pro Ser Met Glu Glu Leu Lys Ala 
        355                 360                 365             


Lys Lys Glu Ser Ser Ser Gly Val Glu Thr Ser Ile Trp Asn Gln Trp 
    370                 375                 380                 


Phe Pro Phe Lys Gly Gly Glu Ile Gly Pro Asn Gly Leu Ile Lys Ala 
385                 390                 395                 400 


Gly Asn Lys Tyr Lys Phe Pro Leu Tyr Leu Val Gly Met Gly Met Leu 
                405                 410                 415     


Asp Asp Glu Ile Asn Ala Leu Glu Leu Gly Gly Pro Ile Asp His Pro 
            420                 425                 430         


Gln Arg Ala His Ala Gln Ala Val Leu Gly Asp Glu Glu Thr Leu Phe 
        435                 440                 445             


Phe Gly Asp Thr Gly Val Gly Lys Asn Pro Val Glu Leu Ile Thr Gly 
    450                 455                 460                 


Trp Phe Ser Gly Trp Lys Glu Thr Ile Met Ala Val Val Ala Ile Phe 
465                 470                 475                 480 


Leu Leu Val Ile Val Leu Tyr Gly Val Leu Arg Cys Cys Pro Thr Ile 
                485                 490                 495     


Cys Val Leu Cys Lys Arg Lys Ser Arg His Arg Thr Lys Asp Met Glu 
            500                 505                 510         


Met Gln Tyr Ile Pro Asn Asn Gln Arg His Trp Arg 
        515                 520                 


<210>  90
<211>  521
<212>  PRT
<213>  Malpais Spring vesiculovirus

<400>  90

Met Glu Ser Leu Leu Lys Ala Ile Cys Val Leu Leu Leu Ile His Cys 
1               5                   10                  15      


Ser Arg Cys Asp Leu Pro Ile Val Phe Pro Asp Gln Lys Glu Leu Leu 
            20                  25                  30          


Trp Asn Pro Val Leu Lys Thr Asn Arg Tyr Cys Pro Gln Thr Arg Glu 
        35                  40                  45              


Ile Ala Pro Leu Asp Lys Pro Lys Thr Leu Lys Ile Thr Thr Gly Val 
    50                  55                  60                  


Pro Val Arg Ser Pro Lys Glu Lys Ile Glu Gly Tyr Leu Cys His Ser 
65                  70                  75                  80  


Gly Lys Trp Val Thr Thr Cys Asp Tyr Arg Trp Tyr Gly Ala Lys Tyr 
                85                  90                  95      


Val Thr His Ser Ile His His Leu Lys Pro Thr Asp Gln Met Cys Arg 
            100                 105                 110         


Asp Ala Ile Ser Gln Tyr Asn Gly Gly Thr Leu Leu Asn Pro Gly Phe 
        115                 120                 125             


Pro Pro Glu Val Cys Gly Tyr Ala Ser Val Thr Asp Ser Glu Leu Ile 
    130                 135                 140                 


Ile Thr Leu Ile Thr Pro His Thr Val Gly Val Asp Asp Tyr Arg Gly 
145                 150                 155                 160 


Leu Trp Ile Asp Pro Ser Phe Pro Asn Gly Glu Cys Asn Ser Ile Val 
                165                 170                 175     


Cys Glu Thr Ile His Asn Ser Thr Lys Trp Val Ser Lys Gly Glu Met 
            180                 185                 190         


Pro Thr Asp Ile Cys Gln Gln Thr Phe Thr Thr Ile Lys Met Asp Val 
        195                 200                 205             


Ser Tyr Pro Ser Asp Thr Thr Ser Gln Gly Ser Leu Leu Ser Phe His 
    210                 215                 220                 


Ser Pro Tyr His Pro His Ile Ser Gly Lys Asp Ile Cys Lys Met Ser 
225                 230                 235                 240 


Tyr Cys Gly Ser Asn Gly Leu Arg Leu Pro Asn Gly Glu Trp Phe Ser 
                245                 250                 255     


Ile Ile Asn Thr Ser Lys Ile Gly Asn Lys Asn Leu Ile Asp Phe Phe 
            260                 265                 270         


Ser Pro Cys Lys Ala Gly Val Glu Val Arg Ser Thr Leu Gln Ser Glu 
        275                 280                 285             


Gly Ser Gln Thr Ile Ala Trp Glu Thr Gln Arg Met Leu Asp Tyr Ala 
    290                 295                 300                 


Leu Cys Gln Asn Thr Trp Asp Lys Phe Glu Arg Gly Glu Pro Leu Ser 
305                 310                 315                 320 


Pro Leu Asp Leu Asn Tyr Leu Ala Pro Arg Val Pro Gly Lys Gly Met 
                325                 330                 335     


Ala Tyr Thr Ile Ile Asn Asn Thr Leu His Ser Ser His Ala Val Tyr 
            340                 345                 350         


Arg Arg Val Trp Ile Glu Gly Pro Ile Ile Gly Glu Met Lys Gly Lys 
        355                 360                 365             


Ile Glu Ser Ala Thr Gly Val Ala Lys Glu Ile Trp Ala Gln Trp Phe 
    370                 375                 380                 


Glu Phe Gly Gln Asn Lys Ile Gly Pro Asn Gly Val Ile Lys Thr Asn 
385                 390                 395                 400 


Asp Gly Ile Lys Phe Pro Leu Tyr Ala Ile Gly Thr Gly Leu Ile Asp 
                405                 410                 415     


Gln Asp Ile His Glu Leu Ser Glu Val Ser Pro Met Asp His Pro His 
            420                 425                 430         


Leu Val His Ala Lys Lys Tyr Val Ser Glu Asp Asp Glu Ile Tyr Phe 
        435                 440                 445             


Gly Asp Thr Gly Val Ser His Asn Pro Val Glu Ile Phe Ser Gly Trp 
    450                 455                 460                 


Phe Thr Asn Trp Lys Glu Gly Leu Met Lys Phe Ser Ile Leu Val Leu 
465                 470                 475                 480 


Ser Ile Leu Ile Phe Tyr Val Val Ile Arg Leu Val Met Cys Ile Pro 
                485                 490                 495     


Leu Lys Cys Lys Lys Glu Arg Lys Pro Arg Leu Glu Phe Glu Leu Gln 
            500                 505                 510         


Pro Arg Glu Trp Glu Tyr Ser Arg Ala 
        515                 520     


<210>  91
<211>  512
<212>  PRT
<213>  Maraba vesiculovirus

<400>  91

Met Leu Arg Leu Phe Leu Phe Cys Phe Leu Ala Leu Gly Ala His Ser 
1               5                   10                  15      


Lys Phe Thr Ile Val Phe Pro His His Gln Lys Gly Asn Trp Lys Asn 
            20                  25                  30          


Val Pro Ser Thr Tyr His Tyr Cys Pro Ser Ser Ser Asp Gln Asn Trp 
        35                  40                  45              


His Asn Asp Leu Thr Gly Val Ser Leu His Val Lys Ile Pro Lys Ser 
    50                  55                  60                  


His Lys Ala Ile Gln Ala Asp Gly Trp Met Cys His Ala Ala Lys Trp 
65                  70                  75                  80  


Val Thr Thr Cys Asp Phe Arg Trp Tyr Gly Pro Lys Tyr Ile Thr His 
                85                  90                  95      


Ser Ile His Ser Met Ser Pro Thr Leu Glu Gln Cys Lys Thr Ser Ile 
            100                 105                 110         


Glu Gln Thr Lys Gln Gly Val Trp Ile Asn Pro Gly Phe Pro Pro Gln 
        115                 120                 125             


Ser Cys Gly Tyr Ala Thr Val Thr Asp Ala Glu Val Val Val Val Gln 
    130                 135                 140                 


Ala Thr Pro His His Val Leu Val Asp Glu Tyr Thr Gly Glu Trp Ile 
145                 150                 155                 160 


Asp Ser Gln Leu Val Gly Gly Lys Cys Ser Lys Glu Val Cys Gln Thr 
                165                 170                 175     


Val His Asn Ser Thr Val Trp His Ala Asp Tyr Lys Ile Thr Gly Leu 
            180                 185                 190         


Cys Glu Ser Asn Leu Ala Ser Val Asp Ile Thr Phe Phe Ser Glu Asp 
        195                 200                 205             


Gly Gln Lys Thr Ser Leu Gly Lys Pro Asn Thr Gly Phe Arg Ser Asn 
    210                 215                 220                 


His Phe Ala Tyr Glu Ser Gly Glu Lys Ala Cys Arg Met Gln Tyr Cys 
225                 230                 235                 240 


Thr Gln Trp Gly Ile Arg Leu Pro Ser Gly Val Trp Phe Glu Leu Val 
                245                 250                 255     


Asp Lys Asp Leu Phe Gln Ala Ala Lys Leu Pro Glu Cys Pro Arg Gly 
            260                 265                 270         


Ser Ser Ile Ser Ala Pro Ser Gln Thr Ser Val Asp Val Ser Leu Ile 
        275                 280                 285             


Gln Asp Val Glu Arg Ile Leu Asp Tyr Ser Leu Cys Gln Glu Thr Trp 
    290                 295                 300                 


Ser Lys Ile Arg Ala Lys Leu Pro Val Ser Pro Val Asp Leu Ser Tyr 
305                 310                 315                 320 


Leu Ala Pro Lys Asn Pro Gly Ser Gly Pro Ala Phe Thr Ile Ile Asn 
                325                 330                 335     


Gly Thr Leu Lys Tyr Phe Glu Thr Arg Tyr Ile Arg Val Asp Ile Ser 
            340                 345                 350         


Asn Pro Ile Ile Pro His Met Val Gly Thr Met Ser Gly Thr Thr Thr 
        355                 360                 365             


Glu Arg Glu Leu Trp Asn Asp Trp Tyr Pro Tyr Glu Asp Val Glu Ile 
    370                 375                 380                 


Gly Pro Asn Gly Val Leu Lys Thr Pro Thr Gly Phe Lys Phe Pro Leu 
385                 390                 395                 400 


Tyr Met Ile Gly His Gly Met Leu Asp Ser Asp Leu His Lys Ser Ser 
                405                 410                 415     


Gln Ala Gln Val Phe Glu His Pro His Ala Lys Asp Ala Ala Ser Gln 
            420                 425                 430         


Leu Pro Asp Asp Glu Thr Leu Phe Phe Gly Asp Thr Gly Leu Ser Lys 
        435                 440                 445             


Asn Pro Val Glu Leu Val Glu Gly Trp Phe Ser Ser Trp Lys Ser Thr 
    450                 455                 460                 


Leu Ala Ser Phe Phe Leu Ile Ile Gly Leu Gly Val Ala Leu Ile Phe 
465                 470                 475                 480 


Ile Ile Arg Ile Ile Val Ala Ile Arg Tyr Lys Tyr Lys Gly Arg Lys 
                485                 490                 495     


Thr Gln Lys Ile Tyr Asn Asp Val Glu Met Ser Arg Leu Gly Asn Lys 
            500                 505                 510         


<210>  92
<211>  513
<212>  PRT
<213>  Morreton vesiculovirus

<400>  92

Met Leu Val Leu Tyr Leu Leu Leu Ser Leu Leu Ala Leu Gly Ala Gln 
1               5                   10                  15      


Cys Lys Phe Thr Ile Val Phe Pro His Asn Gln Lys Gly Asn Trp Lys 
            20                  25                  30          


Asn Val Pro Ala Asn Tyr Gln Tyr Cys Pro Ser Ser Ser Asp Leu Asn 
        35                  40                  45              


Trp His Asn Gly Leu Ile Gly Thr Ser Leu Gln Val Lys Met Pro Lys 
    50                  55                  60                  


Ser His Lys Ala Ile Gln Ala Asp Gly Trp Met Cys His Ala Ala Lys 
65                  70                  75                  80  


Trp Val Thr Thr Cys Asp Phe Arg Trp Tyr Gly Pro Lys Tyr Val Thr 
                85                  90                  95      


His Ser Ile Lys Ser Met Ile Pro Thr Val Asp Gln Cys Lys Glu Ser 
            100                 105                 110         


Ile Ala Gln Thr Lys Gln Gly Thr Trp Leu Asn Pro Gly Phe Pro Pro 
        115                 120                 125             


Gln Ser Cys Gly Tyr Ala Ser Val Thr Asp Ala Glu Ala Val Ile Val 
    130                 135                 140                 


Lys Ala Thr Pro His Gln Val Leu Val Asp Glu Tyr Thr Gly Glu Trp 
145                 150                 155                 160 


Val Asp Ser Gln Phe Pro Thr Gly Lys Cys Asn Lys Asp Ile Cys Pro 
                165                 170                 175     


Thr Val His Asn Ser Thr Thr Trp His Ser Asp Tyr Lys Val Thr Gly 
            180                 185                 190         


Leu Cys Asp Ala Asn Leu Ile Ser Met Asp Ile Thr Phe Phe Ser Glu 
        195                 200                 205             


Asp Gly Lys Leu Thr Ser Leu Gly Lys Glu Gly Thr Gly Phe Arg Ser 
    210                 215                 220                 


Asn Tyr Phe Ala Tyr Glu Asn Gly Asp Lys Ala Cys Arg Met Gln Tyr 
225                 230                 235                 240 


Cys Lys His Trp Gly Val Arg Leu Pro Ser Gly Val Trp Phe Glu Met 
                245                 250                 255     


Ala Asp Lys Asp Ile Tyr Asn Asp Ala Lys Phe Pro Asp Cys Pro Glu 
            260                 265                 270         


Gly Ser Ser Ile Ala Ala Pro Ser Gln Thr Ser Val Asp Val Ser Leu 
        275                 280                 285             


Ile Gln Asp Val Glu Arg Ile Leu Asp Tyr Ser Leu Cys Gln Glu Thr 
    290                 295                 300                 


Trp Ser Lys Ile Arg Ala His Leu Pro Ile Ser Pro Val Asp Leu Ser 
305                 310                 315                 320 


Tyr Leu Ser Pro Lys Asn Pro Gly Thr Gly Pro Ala Phe Thr Ile Ile 
                325                 330                 335     


Asn Gly Thr Leu Lys Tyr Phe Glu Thr Arg Tyr Ile Arg Val Asp Ile 
            340                 345                 350         


Ala Gly Pro Ile Ile Pro Gln Met Arg Gly Val Ile Ser Gly Thr Thr 
        355                 360                 365             


Thr Glu Arg Glu Leu Trp Thr Asp Trp Tyr Pro Tyr Glu Asp Val Glu 
    370                 375                 380                 


Ile Gly Pro Asn Gly Val Leu Lys Thr Ala Thr Gly Tyr Lys Phe Pro 
385                 390                 395                 400 


Leu Tyr Met Ile Gly His Gly Met Leu Asp Ser Asp Leu His Ile Ser 
                405                 410                 415     


Ser Lys Ala Gln Val Phe Glu His Pro His Ile Gln Asp Ala Ala Ser 
            420                 425                 430         


Gln Leu Pro Asp Asp Glu Thr Leu Phe Phe Gly Asp Thr Gly Leu Ser 
        435                 440                 445             


Lys Asn Pro Ile Glu Leu Val Glu Gly Trp Phe Ser Gly Trp Lys Ser 
    450                 455                 460                 


Thr Ile Ala Ser Phe Phe Phe Ile Ile Gly Leu Val Ile Gly Leu Tyr 
465                 470                 475                 480 


Leu Val Leu Arg Ile Gly Ile Ala Leu Cys Ile Lys Cys Arg Val Gln 
                485                 490                 495     


Glu Lys Arg Pro Lys Ile Tyr Thr Asp Val Glu Met Asn Arg Leu Asp 
            500                 505                 510         


Arg 
    


<210>  93
<211>  517
<212>  PRT
<213>  Vesicular stomatitis New Jersey virus

<400>  93

Met Leu Ser Tyr Leu Ile Phe Ala Leu Val Val Ser Pro Ile Leu Gly 
1               5                   10                  15      


Lys Ile Glu Ile Val Phe Pro Gln His Thr Thr Gly Asp Trp Lys Arg 
            20                  25                  30          


Val Pro His Glu Tyr Asn Tyr Cys Pro Thr Ser Ala Asp Lys Asn Ser 
        35                  40                  45              


His Gly Thr Gln Thr Gly Ile Pro Val Glu Leu Thr Met Pro Lys Gly 
    50                  55                  60                  


Leu Thr Thr His Gln Val Asp Gly Phe Met Cys His Ser Ala Leu Trp 
65                  70                  75                  80  


Met Thr Thr Cys Asp Phe Arg Trp Tyr Gly Pro Lys Tyr Ile Thr His 
                85                  90                  95      


Ser Ile His Asn Glu Glu Pro Thr Asp Tyr Gln Cys Leu Glu Ala Ile 
            100                 105                 110         


Lys Ala Tyr Lys Asp Gly Val Ser Phe Asn Pro Gly Phe Pro Pro Gln 
        115                 120                 125             


Ser Cys Gly Tyr Gly Thr Val Thr Asp Ala Glu Ala His Ile Val Thr 
    130                 135                 140                 


Val Thr Pro His Ser Val Lys Val Asp Glu Tyr Thr Gly Glu Trp Ile 
145                 150                 155                 160 


Asp Pro His Phe Ile Gly Gly Arg Cys Lys Gly Gln Ile Cys Glu Thr 
                165                 170                 175     


Val His Asn Ser Thr Lys Trp Phe Thr Ser Ser Asp Gly Glu Ser Val 
            180                 185                 190         


Cys Ser Gln Leu Phe Thr Leu Val Gly Gly Thr Phe Phe Ser Asp Ser 
        195                 200                 205             


Glu Glu Ile Thr Ser Met Gly Leu Pro Glu Thr Gly Ile Arg Ser Asn 
    210                 215                 220                 


Tyr Phe Pro Tyr Val Ser Thr Glu Gly Ile Cys Lys Met Pro Phe Cys 
225                 230                 235                 240 


Arg Lys Pro Gly Tyr Lys Leu Lys Asn Asp Leu Trp Phe Gln Ile Thr 
                245                 250                 255     


Asp Pro Asp Leu Asp Lys Thr Val Arg Asp Leu Pro His Ile Lys Asp 
            260                 265                 270         


Cys Asp Leu Ser Ser Ser Ile Val Thr Pro Gly Glu His Ala Thr Asp 
        275                 280                 285             


Ile Ser Leu Ile Ser Asp Val Glu Arg Ile Leu Asp Tyr Ala Leu Cys 
    290                 295                 300                 


Gln Asn Thr Trp Ser Lys Ile Glu Ala Gly Glu Pro Ile Thr Pro Val 
305                 310                 315                 320 


Asp Leu Ser Tyr Leu Gly Pro Lys Asn Pro Gly Ala Gly Pro Val Phe 
                325                 330                 335     


Thr Ile Ile Asn Gly Ser Leu His Tyr Phe Met Ser Lys Tyr Leu Arg 
            340                 345                 350         


Val Glu Leu Glu Ser Pro Val Ile Pro Arg Met Glu Gly Lys Val Ala 
        355                 360                 365             


Gly Thr Arg Ile Val Arg Gln Leu Trp Asp Gln Trp Phe Pro Phe Gly 
    370                 375                 380                 


Glu Val Glu Ile Gly Pro Asn Gly Val Leu Lys Thr Lys Gln Gly Tyr 
385                 390                 395                 400 


Lys Phe Pro Leu His Ile Ile Gly Thr Gly Glu Val Asp Asn Asp Ile 
                405                 410                 415     


Lys Met Glu Arg Ile Val Lys His Trp Glu His Pro His Ile Glu Ala 
            420                 425                 430         


Ala Gln Thr Phe Leu Lys Lys Asp Asp Thr Glu Glu Val Leu Tyr Tyr 
        435                 440                 445             


Gly Asp Thr Gly Val Ser Lys Asn Pro Val Glu Leu Val Glu Gly Trp 
    450                 455                 460                 


Phe Ser Gly Trp Arg Ser Ser Ile Met Gly Val Leu Ala Val Ile Ile 
465                 470                 475                 480 


Gly Phe Val Ile Leu Ile Phe Leu Ile Arg Leu Ile Gly Val Leu Ser 
                485                 490                 495     


Ser Leu Phe Arg Gln Lys Arg Arg Pro Ile Tyr Lys Ser Asp Val Glu 
            500                 505                 510         


Met Ala His Phe Arg 
        515         


<210>  94
<211>  525
<212>  PRT
<213>  Perinet vesiculovirus

<400>  94

Met Ser Ser Lys Ile Val Leu Ala Ala Ile Cys Leu Cys Ser Val Gln 
1               5                   10                  15      


Tyr Val Ala Cys Ser Phe Gln Ile Val Phe Pro Glu Phe Asn Asn Ala 
            20                  25                  30          


Ala Trp Leu Pro Tyr Leu Lys Thr Ser Arg Tyr Cys Pro Gln Ser Ala 
        35                  40                  45              


Glu Met Glu Phe Glu Arg Arg Val Ser Thr Thr Leu Leu Ser Ala Asp 
    50                  55                  60                  


Val Pro Ile Gly Val Thr Pro Thr Lys Ser Asp Gly Tyr Leu Cys His 
65                  70                  75                  80  


Ala Ala Lys Trp Val Thr Thr Cys Asp Phe Arg Trp Tyr Gly Pro Lys 
                85                  90                  95      


Tyr Val Thr His Ser Ile His Asp Leu Thr Pro Ala Gln Val Asp Cys 
            100                 105                 110         


His Glu Ala Leu Ala Arg Tyr Lys Ala Gly Thr Leu Phe Asn Pro Gly 
        115                 120                 125             


Phe Pro Pro Ala Ser Cys Gly Tyr Ala Thr Ile Thr Asp Ser Glu Gln 
    130                 135                 140                 


Lys Val Val Met Ile Thr Pro His His Val Gly Ile Asp Asp Tyr Arg 
145                 150                 155                 160 


Gly Lys Trp Ile Asp Pro Ile Phe Pro Gly Gly Glu Cys Thr Thr Asn 
                165                 170                 175     


Tyr Cys Glu Thr Leu His Asn Ser Ser Val Trp Leu Pro Ala Asp Glu 
            180                 185                 190         


Lys Ile Val Asp Ile Cys Ala Gln Thr Phe Arg Lys Ile Lys Val Thr 
        195                 200                 205             


Ala Thr Tyr Pro Ser Glu Gly Ala Val Thr Lys Glu Thr Ile Ser Leu 
    210                 215                 220                 


His Ser Ala Tyr His Pro His Val Pro Gly Thr Gly Ile Cys Arg Met 
225                 230                 235                 240 


Thr Tyr Cys Ser Lys Glu Gly Leu Arg Leu Pro Asn Gly Glu Trp Leu 
                245                 250                 255     


Gly Ile Phe Tyr Asp Asn Arg Ile Lys Thr Thr Asp Val Arg Thr Val 
            260                 265                 270         


Phe Pro Ala Cys Pro Asp Gly Leu Glu Val Lys Ser Thr Leu Asn Ser 
        275                 280                 285             


Asp Gly Ala Asn Thr Ile Ala Trp Glu Thr Gln Arg Met Leu Asp Tyr 
    290                 295                 300                 


Ala Leu Cys Gln Ser Thr Trp Asp Lys Val Gln Asn Lys Glu Pro Leu 
305                 310                 315                 320 


Ser Ala Val Asp Leu Ser Tyr Leu Ser Ala Arg Ser Pro Gly Lys Gly 
                325                 330                 335     


Leu Ala Tyr Thr Val Ile Asn Gly Thr Leu His Phe Ala His Val Arg 
            340                 345                 350         


Tyr Val Arg Thr Trp Ile Asp Gly Pro Val Leu Lys Asp Leu Lys Gly 
        355                 360                 365             


Ser Arg Phe Asp Pro Thr Ala Ala Gln Lys Thr Leu Trp Asp Gln Trp 
    370                 375                 380                 


Phe Pro Phe Gly Ser Asn Glu Ile Gly Pro Asn Gly Leu Leu Lys Thr 
385                 390                 395                 400 


Pro Lys Asp Phe Lys Phe Pro Leu Tyr Ile Ile Gly Thr Gly Leu Val 
                405                 410                 415     


Asp Glu Asp Leu Gln Glu Leu Ser Glu Ala Gly Pro Ile Asp His Pro 
            420                 425                 430         


Gln Ile Pro Asp Ala Ser Gly Ile Leu Pro Asn Ser Glu Gln Val Tyr 
        435                 440                 445             


Tyr Gly Asp Thr Gly Val Ser Lys Asn Pro Ile Glu Leu Ile Glu Gly 
    450                 455                 460                 


Trp Phe Ala Asn Trp Lys Glu Thr Val Met Ser Ile Val Gly Leu Val 
465                 470                 475                 480 


Leu Leu Ile Thr Ile Val Phe Thr Val Leu Lys Cys Ile Gly Thr Cys 
                485                 490                 495     


Arg Ser Leu Arg Arg Lys Arg Lys Ile Glu Lys Asp Ile Glu Leu Gln 
            500                 505                 510         


Glu Ile Gly Pro Tyr Gln Pro Thr Thr Tyr Arg Pro Arg 
        515                 520                 525 


<210>  95
<211>  529
<212>  PRT
<213>  Piry vesiculovirus

<400>  95

Met Asp Leu Phe Pro Ile Leu Val Val Val Leu Met Thr Asp Thr Val 
1               5                   10                  15      


Leu Gly Lys Phe Gln Ile Val Phe Pro Asp Gln Asn Glu Leu Glu Trp 
            20                  25                  30          


Arg Pro Val Val Gly Asp Ser Arg His Cys Pro Gln Ser Ser Glu Met 
        35                  40                  45              


Gln Phe Asp Gly Ser Arg Ser Gln Thr Ile Leu Thr Gly Lys Ala Pro 
    50                  55                  60                  


Val Gly Ile Thr Pro Ser Lys Ser Asp Gly Phe Ile Cys His Ala Ala 
65                  70                  75                  80  


Lys Trp Val Thr Thr Cys Asp Phe Arg Trp Tyr Gly Pro Lys Tyr Ile 
                85                  90                  95      


Thr His Ser Ile His His Leu Arg Pro Thr Thr Ser Asp Cys Glu Thr 
            100                 105                 110         


Ala Leu Gln Arg Tyr Lys Asp Gly Ser Leu Ile Asn Leu Gly Phe Pro 
        115                 120                 125             


Pro Glu Ser Cys Gly Tyr Ala Thr Val Thr Asp Ser Glu Ala Met Leu 
    130                 135                 140                 


Val Gln Val Thr Pro His His Val Gly Val Asp Asp Tyr Arg Gly His 
145                 150                 155                 160 


Trp Ile Asp Pro Leu Phe Pro Gly Gly Glu Cys Ser Thr Asn Phe Cys 
                165                 170                 175     


Asp Thr Val His Asn Ser Ser Val Trp Ile Pro Lys Ser Gln Lys Thr 
            180                 185                 190         


Asp Ile Cys Ala Gln Ser Phe Lys Asn Ile Lys Met Thr Ala Ser Tyr 
        195                 200                 205             


Pro Ser Glu Gly Ala Leu Val Ser Asp Arg Phe Ala Phe His Ser Ala 
    210                 215                 220                 


Tyr His Pro Asn Met Pro Gly Ser Thr Val Cys Ile Met Asp Phe Cys 
225                 230                 235                 240 


Glu Gln Lys Gly Leu Arg Phe Thr Asn Gly Glu Trp Met Gly Leu Asn 
                245                 250                 255     


Val Glu Gln Ser Ile Arg Glu Lys Lys Ile Ser Ala Ile Phe Pro Asn 
            260                 265                 270         


Cys Val Ala Gly Thr Glu Ile Arg Ala Thr Leu Glu Ser Glu Gly Ala 
        275                 280                 285             


Arg Thr Leu Thr Trp Glu Thr Gln Arg Met Leu Asp Tyr Ser Leu Cys 
    290                 295                 300                 


Gln Asn Thr Trp Asp Lys Val Ser Arg Lys Glu Pro Leu Ser Pro Leu 
305                 310                 315                 320 


Asp Leu Ser Tyr Leu Ser Pro Arg Ala Pro Gly Lys Gly Met Ala Tyr 
                325                 330                 335     


Thr Val Ile Asn Gly Thr Leu His Ser Ala His Ala Lys Tyr Ile Arg 
            340                 345                 350         


Thr Trp Ile Asp Tyr Gly Glu Met Lys Glu Ile Lys Gly Gly Arg Gly 
        355                 360                 365             


Glu Tyr Ser Lys Ala Pro Glu Leu Leu Trp Ser Gln Trp Phe Asp Phe 
    370                 375                 380                 


Gly Pro Phe Lys Ile Gly Pro Asn Gly Leu Leu His Thr Gly Lys Thr 
385                 390                 395                 400 


Phe Lys Phe Pro Leu Tyr Leu Ile Gly Ala Gly Ile Ile Asp Glu Asp 
                405                 410                 415     


Leu His Glu Leu Asp Glu Ala Ala Pro Ile Asp His Pro Gln Met Pro 
            420                 425                 430         


Asp Ala Lys Ser Val Leu Pro Glu Asp Glu Glu Ile Phe Phe Gly Asp 
        435                 440                 445             


Thr Gly Val Ser Lys Asn Pro Ile Glu Leu Ile Gln Gly Trp Phe Ser 
    450                 455                 460                 


Asn Trp Arg Glu Ser Val Met Ala Ile Val Gly Ile Val Leu Leu Ile 
465                 470                 475                 480 


Val Val Thr Phe Leu Ala Ile Lys Thr Val Arg Val Leu Asn Cys Leu 
                485                 490                 495     


Trp Arg Pro Arg Lys Lys Arg Ile Val Arg Gln Glu Val Asp Val Glu 
            500                 505                 510         


Ser Arg Leu Asn His Phe Glu Met Arg Gly Phe Pro Glu Tyr Val Lys 
        515                 520                 525             


Arg 
    


<210>  96
<211>  556
<212>  PRT
<213>  Radi vesiculovirus

<400>  96

Met Ile Ser Ile Thr Phe Val Tyr Leu Ile Ile Ile Leu Ser Leu Ser 
1               5                   10                  15      


Trp Gly Glu Met Met Ile Pro Phe Pro Asp Val Thr Thr Thr Thr Trp 
            20                  25                  30          


Lys Pro Val Leu Lys Gly Glu His His Cys Pro Ser Ser Ser Asp Val 
        35                  40                  45              


Asp Ile Leu Ser Arg Met Ser Thr Leu Lys Leu Gln Val Arg Ile Pro 
    50                  55                  60                  


Thr Gly Ser Val Ala Ser Lys Ser Asp Gly Leu Leu Cys His Gly Ala 
65                  70                  75                  80  


Lys Trp Val Thr Thr Cys Asp Phe Arg Trp Tyr Gly Ser Lys Tyr Ile 
                85                  90                  95      


Thr His Ser Leu His Ser Ile Arg Pro Thr Leu Ser Gln Cys Thr Glu 
            100                 105                 110         


Ala Ala Lys Ala Tyr Lys Glu Gly Arg Leu Met Ala Pro Gly Phe Pro 
        115                 120                 125             


Pro Glu Ser Cys Gly Trp Asn Ser Val Thr Asp Ser Glu Leu Leu Ser 
    130                 135                 140                 


Ile Leu Val Thr Pro His His Thr Gly Val Asp Asp Tyr Arg Gly Ile 
145                 150                 155                 160 


Trp Ile Asp Ser Met Phe Pro Gly Gly Glu Cys Lys Glu Met Val Cys 
                165                 170                 175     


Asp Thr Val Gln Gly His Thr Ile Trp Met Ser Thr Ser Asn Leu Thr 
            180                 185                 190         


Thr Ala Cys Gly Val Ala Phe Lys Gln Ile Gln Gly Gln Phe Tyr Tyr 
        195                 200                 205             


Leu Asn Ser Gly His Gln Pro Asn Lys Glu Gly Thr Phe Phe His Ser 
    210                 215                 220                 


Pro Asn His Pro Asn Ser Pro Leu Ser Thr Ala Cys Arg Lys Lys Tyr 
225                 230                 235                 240 


Cys Asn Gln Glu Gly Ile Val Ile His Thr Gly Glu Trp Ile Gly Val 
                245                 250                 255     


Pro Trp Asn Thr Arg Ile Arg Asp Val Gln Leu Asp Ser Tyr Thr Asp 
            260                 265                 270         


Leu Cys Ala Glu Ser Thr Glu Ile Lys Ser Thr Ile Gly Ser Ala Pro 
        275                 280                 285             


Ile Arg Val Ile Ala Trp Glu Met Glu Arg Val Met Asp Phe Ala Leu 
    290                 295                 300                 


Cys Gln Thr Val Trp Asp Lys Val Asn Arg Gly Asp Pro Leu Ser Pro 
305                 310                 315                 320 


Leu Asp Leu Ser Tyr Leu Ser Ser Arg Ala Pro Gly Lys Gly Leu Ala 
                325                 330                 335     


Tyr Thr Ile Ile Asn Glu Thr Leu His Val Ala His Val Arg Tyr Ile 
            340                 345                 350         


Arg Thr Tyr Ile Lys Ala Pro Ile Met Glu Glu Ile Lys Gly Ser Arg 
        355                 360                 365             


Gly Asp Arg Ser Ala Ala Glu Ser Val Leu Trp Thr Gln Trp Phe Pro 
    370                 375                 380                 


Tyr Gly Asp Gly Glu Ile Gly Pro Asn Gly Leu Leu Lys Thr Asn Gly 
385                 390                 395                 400 


Ser Phe Lys Phe Pro Phe Tyr Leu Val Gly Met Gly Ala Ile Asp Asp 
                405                 410                 415     


Asp Leu Ile Glu Leu Ser Asn Ala Asp Pro Ile Asp His Pro Gln Lys 
            420                 425                 430         


Ala Ile Ala Ser Val His Leu Asn Thr Asp Glu Glu Leu Phe Phe Gly 
        435                 440                 445             


Asn Thr Gly Ser Asp Ser Asn Pro Val Glu Ala Val Glu Gly Trp Phe 
    450                 455                 460                 


Ala Ser Trp Lys Ser Ala Gly Ile Asn Met Ala Leu Ile Val Leu Cys 
465                 470                 475                 480 


Val Leu Leu Val Leu Ile Phe Leu Arg Ser Leu Pro Ala Leu Ile Lys 
                485                 490                 495     


Leu Ile His Arg Tyr Arg Val Ser Arg Ser Arg Gln Thr Asp Val Glu 
            500                 505                 510         


Leu Asn Ser Ile Asn Glu Thr Ala Arg Thr Gly Ser Val Gly Pro Asp 
        515                 520                 525             


Ile Ile Pro Gly Ala Trp Arg Val His Asp Ser Gly Val Arg Gln Ser 
    530                 535                 540                 


Gln Phe Phe Arg Asn Asn Pro Arg Arg Leu Gly Pro 
545                 550                 555     


<210>  97
<211>  559
<212>  PRT
<213>  Yug Bogdanovac vesiculovirus

<400>  97

Met Ile Ser Ser Thr Leu Ile Leu Val Ile Ile Ser Ala His Ala Phe 
1               5                   10                  15      


Cys Asp Met Ile Ile Pro Phe Pro Asp Val Thr Thr Thr Ser Trp Lys 
            20                  25                  30          


Pro Val Leu Arg Gly Glu His His Cys Pro Ala Ser Asn Asp Leu Asp 
        35                  40                  45              


Met Ala Gly Gly Leu Ser Thr Leu Lys Met Asn Val Lys Ile Pro Ser 
    50                  55                  60                  


Gly Val Val Gly Ser Lys Ser Asp Gly Tyr Leu Cys His Gly Ala Lys 
65                  70                  75                  80  


Trp Val Thr Thr Cys Asp Tyr Arg Trp Tyr Gly Ala Lys Tyr Ile Thr 
                85                  90                  95      


His Ser Leu His Pro Leu Arg Pro Ser Thr Ser Gln Cys Phe Asp Ala 
            100                 105                 110         


Ile Lys Ala Tyr Arg Glu Gly Thr Leu Leu Ser Pro Gly Phe Pro Pro 
        115                 120                 125             


Glu Ser Cys Gly Trp Asn Ser Val Thr Asp Ser Glu Leu Leu Ser Ile 
    130                 135                 140                 


Gln Ile Thr Pro His His Ser Gly Val Asp Asp Tyr Arg Gly Val Trp 
145                 150                 155                 160 


Ile Asp Ser Met Phe Pro Lys Gly Glu Cys Asp Gln Arg Ile Cys Asp 
                165                 170                 175     


Thr Val Gln Glu His Ser Ile Trp Ile Ala Ala Asn Asn Val Ser Ser 
            180                 185                 190         


Ala Cys Ser Ile Ala Phe Lys Gln Leu Glu Gly Tyr Phe Tyr Tyr Arg 
        195                 200                 205             


Asn Ser Gly Ile Gln Pro Asn Lys Asp Gly Thr Phe Phe His Ser Ser 
    210                 215                 220                 


His His Pro Asn Ser Pro Met Ser Ser Cys Cys Arg Ile Lys Tyr Cys 
225                 230                 235                 240 


Asn Gln Glu Gly Leu Arg Leu His Thr Gly Glu Trp Ile Gly Val Ala 
                245                 250                 255     


Trp Asn Thr Lys Ile Arg Asp Val Thr Leu Asp Ser Tyr Thr Asp Thr 
            260                 265                 270         


Cys Pro Gly Gly Thr Glu Val Lys Ser Thr Ile Gly Ser Ser Pro Thr 
        275                 280                 285             


Arg Val Val Ala Trp Glu Met Glu Arg Ile Met Asp Phe Ala Leu Cys 
    290                 295                 300                 


Gln Asn Val Trp Asp Lys Val Asn Arg Gly Glu Gln Leu Ser Pro Leu 
305                 310                 315                 320 


Asp Leu Ser Tyr Leu Ser Ser Arg Ala Pro Gly Lys Gly Leu Ala Tyr 
                325                 330                 335     


Thr Ile Ile Asn Glu Thr Leu His Val Ala His Val Arg Tyr Ile Arg 
            340                 345                 350         


Thr Trp Ile Lys Gly Pro Val Leu Lys Glu Ile Lys Gly Arg Arg Gly 
        355                 360                 365             


Ser Ser Ser Ala Ala Glu Asp Thr Leu Trp Ile Gln Trp Phe Pro Phe 
    370                 375                 380                 


Gly Asp Asn Gln Ile Gly Pro Asn Gly Leu Leu Lys Ser Asn Gly Thr 
385                 390                 395                 400 


Phe Lys Phe Pro Phe Tyr Leu Val Gly Val Gly Ala Leu Asp Glu Asp 
                405                 410                 415     


Leu Ile Glu Met Ala Asn Ala Asp Pro Val Asp His Leu Gln Arg Val 
            420                 425                 430         


Asp Ala Glu Thr His Met Arg Gly Asp Glu Glu Leu Phe Phe Gly Asp 
        435                 440                 445             


Thr Gly Val Ser Lys Asn Pro Ile Glu Ser Val Glu Gly Trp Phe Ser 
    450                 455                 460                 


Asn Trp Ile Ser Gly Leu Phe Asn Ile Ser Ile Ile Val Leu Cys Val 
465                 470                 475                 480 


Leu Ser Val Leu Ile Val Phe Lys Ser Val Ile Thr Leu Ile Arg Val 
                485                 490                 495     


Val Arg Arg Arg Arg Arg Pro Arg Ala Glu Glu Asp Val Glu Leu Asn 
            500                 505                 510         


Asn Met Asn Pro Arg Pro Gln Thr Arg Gln Pro Val Gly Ala Pro Asn 
        515                 520                 525             


Ile Ile Pro Gly Ala Trp Gly Ile Gln Pro Ser His Gly Arg Gly Val 
    530                 535                 540                 


Arg Gln Ser Gln Phe Val Lys Arg Ser Ala Leu Asn Ile Val Thr 
545                 550                 555                 


<210>  98
<211>  511
<212>  PRT
<213>  Indiana vesiculovirus

<400>  98

Met Lys Cys Leu Leu Tyr Leu Ala Leu Leu Phe Ile Gly Val Tyr Cys 
1               5                   10                  15      


Lys Phe Thr Thr Val Phe Pro His Asn Lys Lys Gly Asp Trp Lys Asn 
            20                  25                  30          


Val Pro Ser Asn Tyr His Tyr Cys Pro Ser Ser Ser Asp Leu Asn Trp 
        35                  40                  45              


His Asn Asp Leu Ile Gly Thr Ala Leu Gln Val Lys Met Pro Lys Ser 
    50                  55                  60                  


His Lys Ala Ile Gln Ala Asp Gly Trp Met Cys His Ala Ser Lys Trp 
65                  70                  75                  80  


Val Thr Thr Cys Asp Phe Arg Trp Tyr Gly Pro Lys Tyr Ile Thr His 
                85                  90                  95      


Ser Ile Arg Ser Phe Thr Pro Ser Val Glu Gln Cys Lys Glu Ser Ile 
            100                 105                 110         


Glu Gln Thr Lys Gln Gly Thr Trp Leu Asn Pro Gly Phe Pro Pro Gln 
        115                 120                 125             


Ser Cys Gly Tyr Ala Thr Val Thr Asp Ala Glu Ala Val Ile Val Gln 
    130                 135                 140                 


Val Thr Pro His His Val Leu Val Asp Glu Tyr Thr Gly Glu Trp Val 
145                 150                 155                 160 


Asp Ser Gln Phe Ile Asn Gly Lys Cys Ser Asp Asp Ile Cys Pro Thr 
                165                 170                 175     


Val His Asn Ser Thr Thr Trp His Ser Asp Tyr Lys Val Lys Gly Leu 
            180                 185                 190         


Cys Asp Ser Asn Leu Ile Ser Met Asp Ile Thr Phe Phe Ser Glu Asp 
        195                 200                 205             


Gly Glu Leu Ser Ser Leu Gly Lys Glu Gly Thr Gly Phe Arg Ser Asn 
    210                 215                 220                 


Tyr Phe Ala Tyr Glu Thr Gly Asp Lys Ala Cys Lys Met Gln Tyr Cys 
225                 230                 235                 240 


Lys His Trp Gly Val Arg Leu Pro Ser Gly Val Trp Phe Glu Met Ala 
                245                 250                 255     


Asp Lys Asn Leu Phe Ala Ala Ala Lys Phe Pro Glu Cys Pro Glu Gly 
            260                 265                 270         


Ser Ser Ile Ser Ala Pro Ser Gln Thr Ser Val Asp Val Ser Leu Ile 
        275                 280                 285             


Gln Asp Val Glu Arg Ile Leu Asp Tyr Ser Leu Cys Gln Glu Thr Trp 
    290                 295                 300                 


Ser Lys Ile Arg Ala Gly Leu Pro Ile Ser Pro Val Asp Leu Ser Tyr 
305                 310                 315                 320 


Leu Ala Pro Lys Asn Pro Gly Thr Gly Pro Ala Phe Thr Ile Ile Asn 
                325                 330                 335     


Gly Thr Leu Lys Tyr Phe Glu Thr Arg Tyr Ile Arg Val Asp Ile Ala 
            340                 345                 350         


Ala Pro Ile Leu Ser Arg Met Val Gly Met Ile Ser Gly Thr Thr Thr 
        355                 360                 365             


Glu Arg Glu Leu Trp Glu Asp Trp Ala Pro Tyr Glu Asp Val Glu Ile 
    370                 375                 380                 


Gly Pro Asn Gly Val Leu Arg Thr Ser Ser Gly Tyr Lys Phe Pro Leu 
385                 390                 395                 400 


Tyr Met Ile Gly His Gly Met Leu Asp Ser Asp Leu His Leu Ser Ser 
                405                 410                 415     


Lys Ala Gln Val Phe Glu His Pro His Ile Pro Asp Ala Thr Ser Gln 
            420                 425                 430         


Leu Pro Asp Asp Glu Thr Leu Phe Phe Gly Asp Thr Gly Leu Ser Lys 
        435                 440                 445             


Asp Pro Ile Glu Leu Val Glu Gly Trp Phe Ser Gly Trp Lys Ser Ser 
    450                 455                 460                 


Ile Ala Ser Phe Phe Phe Ile Ile Gly Leu Ile Ile Gly Leu Phe Phe 
465                 470                 475                 480 


Val Leu Arg Ile Gly Val Tyr Leu Cys Ile Lys Leu Lys His Thr Asn 
                485                 490                 495     


Lys Arg Gln Ile Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Lys 
            500                 505                 510     


<210>  99
<211>  511
<212>  PRT
<213>  Indiana vesiculovirus

<400>  99

Met Lys Cys Leu Leu Cys Leu Ala Phe Leu Phe Ile Gly Val Asn Cys 
1               5                   10                  15      


Lys Phe Thr Ile Val Phe Pro His Asn Gln Lys Gly Asn Trp Lys Asn 
            20                  25                  30          


Val Pro Ser Asn Tyr His Tyr Cys Pro Ser Ser Ser Asp Leu Asn Trp 
        35                  40                  45              


His Asn Asp Leu Ile Gly Thr Ala Leu Gln Val Lys Met Pro Lys Ser 
    50                  55                  60                  


His Lys Ala Ile Gln Ala Asp Gly Trp Met Cys His Ala Ser Lys Trp 
65                  70                  75                  80  


Ile Thr Thr Cys Asp Phe Arg Trp Tyr Gly Pro Lys Tyr Ile Thr His 
                85                  90                  95      


Ser Ile Gln Ser Phe Thr Pro Ser Val Glu Gln Cys Lys Glu Ser Ile 
            100                 105                 110         


Glu Gln Thr Lys Gln Gly Thr Trp Leu Asn Pro Gly Phe Pro Pro Gln 
        115                 120                 125             


Ser Cys Gly Tyr Ala Thr Val Thr Asp Ala Glu Ala Val Ile Val Gln 
    130                 135                 140                 


Val Thr Pro His His Val Leu Val Asp Glu Tyr Thr Gly Glu Trp Val 
145                 150                 155                 160 


Asp Ser Gln Phe Ile Asn Gly Lys Cys Ser Asn Asp Ile Cys Leu Thr 
                165                 170                 175     


Val His Asn Ser Thr Thr Trp His Ser Asp Tyr Lys Val Lys Gly Leu 
            180                 185                 190         


Cys Asp Ser Asn Leu Ile Ser Met Asp Ile Thr Phe Phe Ser Glu Asp 
        195                 200                 205             


Gly Glu Leu Ser Ser Leu Gly Lys Ala Gly Thr Gly Phe Arg Ser Asn 
    210                 215                 220                 


Tyr Phe Ala Tyr Glu Thr Gly Asp Lys Ala Cys Lys Met Gln Tyr Cys 
225                 230                 235                 240 


Lys His Trp Gly Val Arg Leu Pro Ser Gly Val Trp Phe Glu Met Ala 
                245                 250                 255     


Asp Lys Asp Leu Phe Ala Ala Ala Lys Phe Pro Glu Cys Pro Glu Gly 
            260                 265                 270         


Ser Ser Ile Ser Ala Pro Ser Gln Thr Ser Val Asp Val Ser Leu Ile 
        275                 280                 285             


Gln Asp Val Glu Arg Ile Leu Asp Tyr Ser Leu Cys Gln Glu Thr Trp 
    290                 295                 300                 


Ser Lys Ile Arg Ala Gly Leu Pro Ile Ser Pro Val Asp Leu Ser Tyr 
305                 310                 315                 320 


Leu Ala Pro Lys Asn Pro Gly Thr Gly Pro Ala Phe Thr Ile Ile Asn 
                325                 330                 335     


Gly Thr Leu Lys Tyr Phe Glu Thr Arg Tyr Ile Arg Val Asp Ile Ala 
            340                 345                 350         


Ala Pro Ile Leu Ser Arg Met Val Gly Met Ile Ser Gly Thr Asn Thr 
        355                 360                 365             


Glu Arg Glu Leu Trp Glu Asp Trp Ala Pro Tyr Glu Asp Val Glu Ile 
    370                 375                 380                 


Gly Pro Asn Gly Val Leu Arg Thr Ser Ser Gly Tyr Lys Phe Pro Leu 
385                 390                 395                 400 


Tyr Met Ile Gly His Gly Met Leu Asp Ser Asp Leu His Leu Ser Ser 
                405                 410                 415     


Lys Val Gln Val Phe Glu His Pro His Ile Gln Asp Ala Ala Ser Gln 
            420                 425                 430         


Leu Pro Asp Asp Glu Thr Leu Phe Phe Gly Asp Thr Gly Leu Ser Lys 
        435                 440                 445             


Asn Pro Ile Glu Leu Val Glu Gly Trp Phe Ser Gly Trp Lys Ser Ser 
    450                 455                 460                 


Ile Ala Ser Phe Phe Phe Ile Ile Gly Leu Ile Ile Gly Leu Phe Leu 
465                 470                 475                 480 


Val Leu Arg Val Gly Ile Tyr Leu Cys Ile Lys Leu Lys His Thr Arg 
                485                 490                 495     


Lys Arg Lys Ile Tyr Ala Asp Ile Glu Met Asn Arg Leu Gly Lys 
            500                 505                 510     


<210>  100
<211>  546
<212>  PRT
<213>  Nipah Virus

<400>  100

Met Val Val Ile Leu Asp Lys Arg Cys Tyr Cys Asn Leu Leu Ile Leu 
1               5                   10                  15      


Ile Leu Met Ile Ser Glu Cys Ser Val Gly Ile Leu His Tyr Glu Lys 
            20                  25                  30          


Leu Ser Lys Ile Gly Leu Val Lys Gly Val Thr Arg Lys Tyr Lys Ile 
        35                  40                  45              


Lys Ser Asn Pro Leu Thr Lys Asp Ile Val Ile Lys Met Ile Pro Asn 
    50                  55                  60                  


Val Ser Asn Met Ser Gln Cys Thr Gly Ser Val Met Glu Asn Tyr Lys 
65                  70                  75                  80  


Thr Arg Leu Asn Gly Ile Leu Thr Pro Ile Lys Gly Ala Leu Glu Ile 
                85                  90                  95      


Tyr Lys Asn Asn Thr His Asp Leu Val Gly Asp Val Arg Leu Ala Gly 
            100                 105                 110         


Val Ile Met Ala Gly Val Ala Ile Gly Ile Ala Thr Ala Ala Gln Ile 
        115                 120                 125             


Thr Ala Gly Val Ala Leu Tyr Glu Ala Met Lys Asn Ala Asp Asn Ile 
    130                 135                 140                 


Asn Lys Leu Lys Ser Ser Ile Glu Ser Thr Asn Glu Ala Val Val Lys 
145                 150                 155                 160 


Leu Gln Glu Thr Ala Glu Lys Thr Val Tyr Val Leu Thr Ala Leu Gln 
                165                 170                 175     


Asp Tyr Ile Asn Thr Asn Leu Val Pro Thr Ile Asp Lys Ile Ser Cys 
            180                 185                 190         


Lys Gln Thr Glu Leu Ser Leu Asp Leu Ala Leu Ser Lys Tyr Leu Ser 
        195                 200                 205             


Asp Leu Leu Phe Val Phe Gly Pro Asn Leu Gln Asp Pro Val Ser Asn 
    210                 215                 220                 


Ser Met Thr Ile Gln Ala Ile Ser Gln Ala Phe Gly Gly Asn Tyr Glu 
225                 230                 235                 240 


Thr Leu Leu Arg Thr Leu Gly Tyr Ala Thr Glu Asp Phe Asp Asp Leu 
                245                 250                 255     


Leu Glu Ser Asp Ser Ile Thr Gly Gln Ile Ile Tyr Val Asp Leu Ser 
            260                 265                 270         


Ser Tyr Tyr Ile Ile Val Arg Val Tyr Phe Pro Ile Leu Thr Glu Ile 
        275                 280                 285             


Gln Gln Ala Tyr Ile Gln Glu Leu Leu Pro Val Ser Phe Asn Asn Asp 
    290                 295                 300                 


Asn Ser Glu Trp Ile Ser Ile Val Pro Asn Phe Ile Leu Val Arg Asn 
305                 310                 315                 320 


Thr Leu Ile Ser Asn Ile Glu Ile Gly Phe Cys Leu Ile Thr Lys Arg 
                325                 330                 335     


Ser Val Ile Cys Asn Gln Asp Tyr Ala Thr Pro Met Thr Asn Asn Met 
            340                 345                 350         


Arg Glu Cys Leu Thr Gly Ser Thr Glu Lys Cys Pro Arg Glu Leu Val 
        355                 360                 365             


Val Ser Ser His Val Pro Arg Phe Ala Leu Ser Asn Gly Val Leu Phe 
    370                 375                 380                 


Ala Asn Cys Ile Ser Val Thr Cys Gln Cys Gln Thr Thr Gly Arg Ala 
385                 390                 395                 400 


Ile Ser Gln Ser Gly Glu Gln Thr Leu Leu Met Ile Asp Asn Thr Thr 
                405                 410                 415     


Cys Pro Thr Ala Val Leu Gly Asn Val Ile Ile Ser Leu Gly Lys Tyr 
            420                 425                 430         


Leu Gly Ser Val Asn Tyr Asn Ser Glu Gly Ile Ala Ile Gly Pro Pro 
        435                 440                 445             


Val Phe Thr Asp Lys Val Asp Ile Ser Ser Gln Ile Ser Ser Met Asn 
    450                 455                 460                 


Gln Ser Leu Gln Gln Ser Lys Asp Tyr Ile Lys Glu Ala Gln Arg Leu 
465                 470                 475                 480 


Leu Asp Thr Val Asn Pro Ser Leu Ile Ser Met Leu Ser Met Ile Ile 
                485                 490                 495     


Leu Tyr Val Leu Ser Ile Ala Ser Leu Cys Ile Gly Leu Ile Thr Phe 
            500                 505                 510         


Ile Ser Phe Ile Ile Val Glu Lys Lys Arg Asn Thr Tyr Ser Arg Leu 
        515                 520                 525             


Glu Asp Arg Arg Val Arg Pro Thr Ser Ser Gly Asp Leu Tyr Tyr Ile 
    530                 535                 540                 


Gly Thr 
545     


<210>  101
<211>  602
<212>  PRT
<213>  Nipah Virus

<400>  101

Met Pro Ala Glu Asn Lys Lys Val Arg Phe Glu Asn Thr Thr Ser Asp 
1               5                   10                  15      


Lys Gly Lys Ile Pro Ser Lys Val Ile Lys Ser Tyr Tyr Gly Thr Met 
            20                  25                  30          


Asp Ile Lys Lys Ile Asn Glu Gly Leu Leu Asp Ser Lys Ile Leu Ser 
        35                  40                  45              


Ala Phe Asn Thr Val Ile Ala Leu Leu Gly Ser Ile Val Ile Ile Val 
    50                  55                  60                  


Met Asn Ile Met Ile Ile Gln Asn Tyr Thr Arg Ser Thr Asp Asn Gln 
65                  70                  75                  80  


Ala Val Ile Lys Asp Ala Leu Gln Gly Ile Gln Gln Gln Ile Lys Gly 
                85                  90                  95      


Leu Ala Asp Lys Ile Gly Thr Glu Ile Gly Pro Lys Val Ser Leu Ile 
            100                 105                 110         


Asp Thr Ser Ser Thr Ile Thr Ile Pro Ala Asn Ile Gly Leu Leu Gly 
        115                 120                 125             


Ser Lys Ile Ser Gln Ser Thr Ala Ser Ile Asn Glu Asn Val Asn Glu 
    130                 135                 140                 


Lys Cys Lys Phe Thr Leu Pro Pro Leu Lys Ile His Glu Cys Asn Ile 
145                 150                 155                 160 


Ser Cys Pro Asn Pro Leu Pro Phe Arg Glu Tyr Arg Pro Gln Thr Glu 
                165                 170                 175     


Gly Val Ser Asn Leu Val Gly Leu Pro Asn Asn Ile Cys Leu Gln Lys 
            180                 185                 190         


Thr Ser Asn Gln Ile Leu Lys Pro Lys Leu Ile Ser Tyr Thr Leu Pro 
        195                 200                 205             


Val Val Gly Gln Ser Gly Thr Cys Ile Thr Asp Pro Leu Leu Ala Met 
    210                 215                 220                 


Asp Glu Gly Tyr Phe Ala Tyr Ser His Leu Glu Arg Ile Gly Ser Cys 
225                 230                 235                 240 


Ser Arg Gly Val Ser Lys Gln Arg Ile Ile Gly Val Gly Glu Val Leu 
                245                 250                 255     


Asp Arg Gly Asp Glu Val Pro Ser Leu Phe Met Thr Asn Val Trp Thr 
            260                 265                 270         


Pro Pro Asn Pro Asn Thr Val Tyr His Cys Ser Ala Val Tyr Asn Asn 
        275                 280                 285             


Glu Phe Tyr Tyr Val Leu Cys Ala Val Ser Thr Val Gly Asp Pro Ile 
    290                 295                 300                 


Leu Asn Ser Thr Tyr Trp Ser Gly Ser Leu Met Met Thr Arg Leu Ala 
305                 310                 315                 320 


Val Lys Pro Lys Ser Asn Gly Gly Gly Tyr Asn Gln His Gln Leu Ala 
                325                 330                 335     


Leu Arg Ser Ile Glu Lys Gly Arg Tyr Asp Lys Val Met Pro Tyr Gly 
            340                 345                 350         


Pro Ser Gly Ile Lys Gln Gly Asp Thr Leu Tyr Phe Pro Ala Val Gly 
        355                 360                 365             


Phe Leu Val Arg Thr Glu Phe Lys Tyr Asn Asp Ser Asn Cys Pro Ile 
    370                 375                 380                 


Thr Lys Cys Gln Tyr Ser Lys Pro Glu Asn Cys Arg Leu Ser Met Gly 
385                 390                 395                 400 


Ile Arg Pro Asn Ser His Tyr Ile Leu Arg Ser Gly Leu Leu Lys Tyr 
                405                 410                 415     


Asn Leu Ser Asp Gly Glu Asn Pro Lys Val Val Phe Ile Glu Ile Ser 
            420                 425                 430         


Asp Gln Arg Leu Ser Ile Gly Ser Pro Ser Lys Ile Tyr Asp Ser Leu 
        435                 440                 445             


Gly Gln Pro Val Phe Tyr Gln Ala Ser Phe Ser Trp Asp Thr Met Ile 
    450                 455                 460                 


Lys Phe Gly Asp Val Leu Thr Val Asn Pro Leu Val Val Asn Trp Arg 
465                 470                 475                 480 


Asn Asn Thr Val Ile Ser Arg Pro Gly Gln Ser Gln Cys Pro Arg Phe 
                485                 490                 495     


Asn Thr Cys Pro Glu Ile Cys Trp Glu Gly Val Tyr Asn Asp Ala Phe 
            500                 505                 510         


Leu Ile Asp Arg Ile Asn Trp Ile Ser Ala Gly Val Phe Leu Asp Ser 
        515                 520                 525             


Asn Gln Thr Ala Glu Asn Pro Val Phe Thr Val Phe Lys Asp Asn Glu 
    530                 535                 540                 


Ile Leu Tyr Arg Ala Gln Leu Ala Ser Glu Asp Thr Asn Ala Gln Lys 
545                 550                 555                 560 


Thr Ile Thr Asn Cys Phe Leu Leu Lys Asn Lys Ile Trp Cys Ile Ser 
                565                 570                 575     


Leu Val Glu Ile Tyr Asp Thr Gly Asp Asn Val Ile Arg Pro Lys Leu 
            580                 585                 590         


Phe Ala Val Lys Ile Pro Glu Gln Cys Thr 
        595                 600         


<210>  102
<211>  546
<212>  PRT
<213>  Hendra Virus

<400>  102

Met Ala Thr Gln Glu Val Arg Leu Lys Cys Leu Leu Cys Gly Ile Ile 
1               5                   10                  15      


Val Leu Val Leu Ser Leu Glu Gly Leu Gly Ile Leu His Tyr Glu Lys 
            20                  25                  30          


Leu Ser Lys Ile Gly Leu Val Lys Gly Ile Thr Arg Lys Tyr Lys Ile 
        35                  40                  45              


Lys Ser Asn Pro Leu Thr Lys Asp Ile Val Ile Lys Met Ile Pro Asn 
    50                  55                  60                  


Val Ser Asn Val Ser Lys Cys Thr Gly Thr Val Met Glu Asn Tyr Lys 
65                  70                  75                  80  


Ser Arg Leu Thr Gly Ile Leu Ser Pro Ile Lys Gly Ala Ile Glu Leu 
                85                  90                  95      


Tyr Asn Asn Asn Thr His Asp Leu Val Gly Asp Val Lys Leu Ala Gly 
            100                 105                 110         


Val Val Met Ala Gly Ile Ala Ile Gly Ile Ala Thr Ala Ala Gln Ile 
        115                 120                 125             


Thr Ala Gly Val Ala Leu Tyr Glu Ala Met Lys Asn Ala Asp Asn Ile 
    130                 135                 140                 


Asn Lys Leu Lys Ser Ser Ile Glu Ser Thr Asn Glu Ala Val Val Lys 
145                 150                 155                 160 


Leu Gln Glu Thr Ala Glu Lys Thr Val Tyr Val Leu Thr Ala Leu Gln 
                165                 170                 175     


Asp Tyr Ile Asn Thr Asn Leu Val Pro Thr Ile Asp Gln Ile Ser Cys 
            180                 185                 190         


Lys Gln Thr Glu Leu Ala Leu Asp Leu Ala Leu Ser Lys Tyr Leu Ser 
        195                 200                 205             


Asp Leu Leu Phe Val Phe Gly Pro Asn Leu Gln Asp Pro Val Ser Asn 
    210                 215                 220                 


Ser Met Thr Ile Gln Ala Ile Ser Gln Ala Phe Gly Gly Asn Tyr Glu 
225                 230                 235                 240 


Thr Leu Leu Arg Thr Leu Gly Tyr Ala Thr Glu Asp Phe Asp Asp Leu 
                245                 250                 255     


Leu Glu Ser Asp Ser Ile Ala Gly Gln Ile Val Tyr Val Asp Leu Ser 
            260                 265                 270         


Ser Tyr Tyr Ile Ile Val Arg Val Tyr Phe Pro Ile Leu Thr Glu Ile 
        275                 280                 285             


Gln Gln Ala Tyr Val Gln Glu Leu Leu Pro Val Ser Phe Asn Asn Asp 
    290                 295                 300                 


Asn Ser Glu Trp Ile Ser Ile Val Pro Asn Phe Val Leu Ile Arg Asn 
305                 310                 315                 320 


Thr Leu Ile Ser Asn Ile Glu Val Lys Tyr Cys Leu Ile Thr Lys Lys 
                325                 330                 335     


Ser Val Ile Cys Asn Gln Asp Tyr Ala Thr Pro Met Thr Ala Ser Val 
            340                 345                 350         


Arg Glu Cys Leu Thr Gly Ser Thr Asp Lys Cys Pro Arg Glu Leu Val 
        355                 360                 365             


Val Ser Ser His Val Pro Arg Phe Ala Leu Ser Gly Gly Val Leu Phe 
    370                 375                 380                 


Ala Asn Cys Ile Ser Val Thr Cys Gln Cys Gln Thr Thr Gly Arg Ala 
385                 390                 395                 400 


Ile Ser Gln Ser Gly Glu Gln Thr Leu Leu Met Ile Asp Asn Thr Thr 
                405                 410                 415     


Cys Thr Thr Val Val Leu Gly Asn Ile Ile Ile Ser Leu Gly Lys Tyr 
            420                 425                 430         


Leu Gly Ser Ile Asn Tyr Asn Ser Glu Ser Ile Ala Val Gly Pro Pro 
        435                 440                 445             


Val Tyr Thr Asp Lys Val Asp Ile Ser Ser Gln Ile Ser Ser Met Asn 
    450                 455                 460                 


Gln Ser Leu Gln Gln Ser Lys Asp Tyr Ile Lys Glu Ala Gln Lys Ile 
465                 470                 475                 480 


Leu Asp Thr Val Asn Pro Ser Leu Ile Ser Met Leu Ser Met Ile Ile 
                485                 490                 495     


Leu Tyr Val Leu Ser Ile Ala Ala Leu Cys Ile Gly Leu Ile Thr Phe 
            500                 505                 510         


Ile Ser Phe Val Ile Val Glu Lys Lys Arg Gly Asn Tyr Ser Arg Leu 
        515                 520                 525             


Asp Asp Arg Gln Val Arg Pro Val Ser Asn Gly Asp Leu Tyr Tyr Ile 
    530                 535                 540                 


Gly Thr 
545     


<210>  103
<211>  603
<212>  PRT
<213>  Hendra Virus

<400>  103

Met Ala Asp Ser Lys Leu Val Ser Leu Asn Asn Asn Leu Ser Gly Lys 
1               5                   10                  15      


Ile Lys Asp Gln Gly Lys Val Ile Lys Asn Tyr Tyr Gly Thr Met Asp 
            20                  25                  30          


Ile Lys Lys Ile Asn Asp Gly Leu Leu Asp Ser Lys Ile Leu Gly Ala 
        35                  40                  45              


Phe Asn Thr Val Ile Ala Leu Leu Gly Ser Ile Ile Ile Ile Val Met 
    50                  55                  60                  


Asn Ile Met Ile Ile Gln Asn Tyr Thr Arg Thr Thr Asp Asn Gln Ala 
65                  70                  75                  80  


Leu Ile Lys Glu Ser Leu Gln Ser Val Gln Gln Gln Ile Lys Ala Leu 
                85                  90                  95      


Thr Asp Lys Ile Gly Thr Glu Ile Gly Pro Lys Val Ser Leu Ile Asp 
            100                 105                 110         


Thr Ser Ser Thr Ile Thr Ile Pro Ala Asn Ile Gly Leu Leu Gly Ser 
        115                 120                 125             


Lys Ile Ser Gln Ser Thr Ser Ser Ile Asn Glu Asn Val Asn Asp Lys 
    130                 135                 140                 


Cys Lys Phe Thr Leu Pro Pro Leu Lys Ile His Glu Cys Asn Ile Ser 
145                 150                 155                 160 


Cys Pro Asn Pro Leu Pro Phe Arg Glu Tyr Arg Pro Ile Ser Gln Gly 
                165                 170                 175     


Val Ser Asp Leu Val Gly Leu Pro Asn Gln Ile Cys Leu Gln Lys Thr 
            180                 185                 190         


Thr Ser Thr Ile Leu Lys Pro Arg Leu Ile Ser Tyr Thr Leu Pro Ile 
        195                 200                 205             


Asn Thr Arg Glu Gly Val Cys Ile Thr Asp Pro Leu Leu Ala Val Asp 
    210                 215                 220                 


Asn Gly Phe Phe Ala Tyr Ser His Leu Glu Lys Ile Gly Ser Cys Thr 
225                 230                 235                 240 


Arg Gly Ile Ala Lys Gln Arg Ile Ile Gly Val Gly Glu Val Leu Asp 
                245                 250                 255     


Arg Gly Asp Lys Val Pro Ser Met Phe Met Thr Asn Val Trp Thr Pro 
            260                 265                 270         


Pro Asn Pro Ser Thr Ile His His Cys Ser Ser Thr Tyr His Glu Asp 
        275                 280                 285             


Phe Tyr Tyr Thr Leu Cys Ala Val Ser His Val Gly Asp Pro Ile Leu 
    290                 295                 300                 


Asn Ser Thr Ser Trp Thr Glu Ser Leu Ser Leu Ile Arg Leu Ala Val 
305                 310                 315                 320 


Arg Pro Lys Ser Asp Ser Gly Asp Tyr Asn Gln Lys Tyr Ile Ala Ile 
                325                 330                 335     


Thr Lys Val Glu Arg Gly Lys Tyr Asp Lys Val Met Pro Tyr Gly Pro 
            340                 345                 350         


Ser Gly Ile Lys Gln Gly Asp Thr Leu Tyr Phe Pro Ala Val Gly Phe 
        355                 360                 365             


Leu Pro Arg Thr Glu Phe Gln Tyr Asn Asp Ser Asn Cys Pro Ile Ile 
    370                 375                 380                 


His Cys Lys Tyr Ser Lys Ala Glu Asn Cys Arg Leu Ser Met Gly Val 
385                 390                 395                 400 


Asn Ser Lys Ser His Tyr Ile Leu Arg Ser Gly Leu Leu Lys Tyr Asn 
                405                 410                 415     


Leu Ser Leu Gly Gly Asp Ile Ile Leu Gln Phe Ile Glu Ile Ala Asp 
            420                 425                 430         


Asn Arg Leu Thr Ile Gly Ser Pro Ser Lys Ile Tyr Asn Ser Leu Gly 
        435                 440                 445             


Gln Pro Val Phe Tyr Gln Ala Ser Tyr Ser Trp Asp Thr Met Ile Lys 
    450                 455                 460                 


Leu Gly Asp Val Asp Thr Val Asp Pro Leu Arg Val Gln Trp Arg Asn 
465                 470                 475                 480 


Asn Ser Val Ile Ser Arg Pro Gly Gln Ser Gln Cys Pro Arg Phe Asn 
                485                 490                 495     


Val Cys Pro Glu Val Cys Trp Glu Gly Thr Tyr Asn Asp Ala Phe Leu 
            500                 505                 510         


Ile Asp Arg Leu Asn Trp Val Ser Ala Gly Val Tyr Leu Asn Ser Asn 
        515                 520                 525             


Gln Thr Ala Glu Asn Pro Val Phe Ala Val Phe Lys Asp Asn Glu Ile 
    530                 535                 540                 


Leu Tyr Gln Val Pro Leu Ala Glu Asp Asp Thr Asn Ala Gln Lys Thr 
545                 550                 555                 560 


Ile Thr Asp Cys Phe Leu Leu Glu Asn Val Ile Trp Cys Ile Ser Leu 
                565                 570                 575     


Val Glu Ile Tyr Asp Thr Gly Asp Ser Val Ile Arg Pro Lys Leu Phe 
            580                 585                 590         


Ala Val Lys Ile Pro Ala Gln Cys Ser Glu Ser 
        595                 600             


<210>  104
<211>  552
<212>  PRT
<213>  Newcastle disease virus

<400>  104

Met Gly Ser Arg Pro Ser Thr Lys Asn Pro Ala Pro Met Met Leu Thr 
1               5                   10                  15      


Ile Arg Val Ala Leu Val Leu Ser Cys Ile Cys Pro Ala Asn Ser Ile 
            20                  25                  30          


Asp Gly Arg Pro Leu Ala Ala Ala Gly Ile Val Val Thr Gly Asp Lys 
        35                  40                  45              


Ala Val Asn Ile Tyr Thr Ser Ser Gln Thr Gly Ser Ile Ile Val Lys 
    50                  55                  60                  


Leu Leu Pro Asn Leu Pro Lys Asp Lys Glu Ala Cys Ala Lys Ala Pro 
65                  70                  75                  80  


Leu Asp Ala Tyr Asn Arg Thr Leu Thr Thr Leu Leu Thr Pro Leu Gly 
                85                  90                  95      


Asp Ser Ile Arg Arg Ile Gln Glu Ser Val Thr Thr Ser Gly Gly Gly 
            100                 105                 110         


Arg Gln Gly Arg Leu Ile Gly Ala Ile Ile Gly Gly Val Ala Leu Gly 
        115                 120                 125             


Val Ala Thr Ala Ala Gln Ile Thr Ala Ala Ala Ala Leu Ile Gln Ala 
    130                 135                 140                 


Lys Gln Asn Ala Ala Asn Ile Leu Arg Leu Lys Glu Ser Ile Ala Ala 
145                 150                 155                 160 


Thr Asn Glu Ala Val His Glu Val Thr Asp Gly Leu Ser Gln Leu Ala 
                165                 170                 175     


Val Ala Val Gly Lys Met Gln Gln Phe Val Asn Asp Gln Phe Asn Lys 
            180                 185                 190         


Thr Ala Gln Glu Leu Asp Cys Ile Lys Ile Ala Gln Gln Val Gly Val 
        195                 200                 205             


Glu Leu Asn Leu Tyr Leu Thr Glu Leu Thr Thr Val Phe Gly Pro Gln 
    210                 215                 220                 


Ile Thr Ser Pro Ala Leu Asn Lys Leu Thr Ile Gln Ala Leu Tyr Asn 
225                 230                 235                 240 


Leu Ala Gly Gly Asn Met Asp Tyr Leu Leu Thr Lys Leu Gly Val Gly 
                245                 250                 255     


Asn Asn Gln Leu Ser Ser Leu Ile Gly Ser Gly Leu Ile Thr Gly Asn 
            260                 265                 270         


Pro Ile Leu Tyr Asp Ser Gln Thr Gln Leu Leu Gly Ile Gln Val Thr 
        275                 280                 285             


Ala Pro Ser Val Gly Asn Leu Asn Asn Met Arg Ala Thr Tyr Leu Glu 
    290                 295                 300                 


Thr Leu Ser Val Ser Thr Thr Arg Gly Phe Ala Ser Ala Leu Val Pro 
305                 310                 315                 320 


Lys Val Val Thr Gln Val Gly Ser Val Ile Glu Glu Leu Asp Thr Ser 
                325                 330                 335     


Tyr Cys Ile Glu Thr Asp Leu Asp Leu Tyr Cys Thr Arg Ile Val Thr 
            340                 345                 350         


Phe Pro Met Ser Pro Gly Ile Tyr Ser Cys Leu Ser Gly Asn Thr Ser 
        355                 360                 365             


Ala Cys Met Tyr Ser Lys Thr Glu Gly Ala Leu Thr Thr Pro Tyr Met 
    370                 375                 380                 


Thr Ile Lys Gly Ser Val Ile Ala Asn Cys Lys Met Thr Thr Cys Arg 
385                 390                 395                 400 


Cys Val Asn Pro Pro Gly Ile Ile Ser Gln Asn Tyr Gly Glu Ala Val 
                405                 410                 415     


Ser Leu Ile Asp Lys Gln Ser Cys Asn Val Leu Ser Leu Gly Gly Ile 
            420                 425                 430         


Thr Leu Arg Leu Ser Gly Glu Phe Asp Val Thr Tyr Gln Lys Asn Ile 
        435                 440                 445             


Ser Ile Gln Asp Ser Gln Val Ile Ile Thr Gly Asn Leu Asp Ile Ser 
    450                 455                 460                 


Thr Glu Leu Gly Asn Val Asn Asn Ser Ile Ser Asn Ala Leu Asn Lys 
465                 470                 475                 480 


Leu Glu Glu Ser Asn Arg Lys Leu Asp Lys Val Asn Val Lys Leu Thr 
                485                 490                 495     


Ser Thr Ser Ala Leu Ile Thr Tyr Ile Val Leu Thr Ile Ile Ser Leu 
            500                 505                 510         


Val Phe Gly Ile Leu Ser Leu Ile Leu Ala Cys Tyr Leu Met Tyr Lys 
        515                 520                 525             


Gln Lys Ala Gln Gln Lys Thr Leu Leu Trp Leu Gly Asn Asn Thr Leu 
    530                 535                 540                 


Asp Gln Met Arg Ala Thr Thr Lys 
545                 550         


<210>  105
<211>  577
<212>  PRT
<213>  Newcastle disease virus

<400>  105

Met Asp Arg Ala Val Ser Gln Val Ala Leu Glu Asn Asp Glu Arg Glu 
1               5                   10                  15      


Ala Lys Asn Thr Trp Arg Leu Ile Phe Arg Ile Ala Ile Leu Phe Leu 
            20                  25                  30          


Thr Val Val Thr Leu Ala Ile Ser Val Ala Ser Leu Leu Tyr Ser Met 
        35                  40                  45              


Gly Ala Ser Thr Pro Ser Asp Leu Val Gly Ile Pro Thr Arg Ile Ser 
    50                  55                  60                  


Arg Ala Glu Glu Lys Ile Thr Ser Thr Leu Gly Ser Asn Gln Asp Val 
65                  70                  75                  80  


Val Asp Arg Ile Tyr Lys Gln Val Ala Leu Glu Ser Pro Leu Ala Leu 
                85                  90                  95      


Leu Asn Thr Glu Thr Thr Ile Met Asn Ala Ile Thr Ser Leu Ser Tyr 
            100                 105                 110         


Gln Ile Asn Gly Ala Ala Asn Asn Ser Gly Trp Gly Ala Pro Ile His 
        115                 120                 125             


Asp Pro Asp Tyr Ile Gly Gly Ile Gly Lys Glu Leu Ile Val Asp Asp 
    130                 135                 140                 


Ala Ser Asp Val Thr Ser Phe Tyr Pro Ser Ala Phe Gln Glu His Leu 
145                 150                 155                 160 


Asn Phe Ile Pro Ala Pro Thr Thr Gly Ser Gly Cys Thr Arg Ile Pro 
                165                 170                 175     


Ser Phe Asp Met Ser Ala Thr His Tyr Cys Tyr Thr His Asn Val Ile 
            180                 185                 190         


Leu Ser Gly Cys Arg Asp His Ser His Ser Tyr Gln Tyr Leu Ala Leu 
        195                 200                 205             


Gly Val Leu Arg Thr Ser Ala Thr Gly Arg Val Phe Phe Ser Thr Leu 
    210                 215                 220                 


Arg Ser Ile Asn Leu Asp Asp Thr Gln Asn Arg Lys Ser Cys Ser Val 
225                 230                 235                 240 


Ser Ala Thr Pro Leu Gly Cys Asp Met Leu Cys Ser Lys Val Thr Glu 
                245                 250                 255     


Thr Glu Glu Glu Asp Tyr Asn Ser Ala Val Pro Thr Arg Met Val His 
            260                 265                 270         


Gly Arg Leu Gly Phe Asp Gly Gln Tyr His Glu Lys Asp Leu Asp Val 
        275                 280                 285             


Thr Thr Leu Phe Gly Asp Trp Val Ala Asn Tyr Pro Gly Val Gly Gly 
    290                 295                 300                 


Gly Ser Phe Ile Asp Ser Arg Val Trp Phe Ser Val Tyr Gly Gly Leu 
305                 310                 315                 320 


Lys Pro Asn Ser Pro Ser Asp Thr Val Gln Glu Gly Lys Tyr Val Ile 
                325                 330                 335     


Tyr Lys Arg Tyr Asn Asp Thr Cys Pro Asp Glu Gln Asp Tyr Gln Ile 
            340                 345                 350         


Arg Met Ala Lys Ser Ser Tyr Lys Pro Gly Arg Phe Gly Gly Lys Arg 
        355                 360                 365             


Ile Gln Gln Ala Ile Leu Ser Ile Lys Val Ser Thr Ser Leu Gly Glu 
    370                 375                 380                 


Asp Pro Val Leu Thr Val Pro Pro Asn Thr Val Thr Leu Met Gly Ala 
385                 390                 395                 400 


Glu Gly Arg Ile Leu Thr Val Gly Thr Ser His Phe Leu Tyr Gln Arg 
                405                 410                 415     


Gly Ser Ser Tyr Phe Ser Pro Ala Leu Leu Tyr Pro Met Thr Val Ser 
            420                 425                 430         


Asn Lys Thr Ala Thr Leu His Ser Pro Tyr Thr Phe Asn Ala Phe Thr 
        435                 440                 445             


Arg Pro Gly Ser Ile Pro Cys Gln Ala Ser Ala Arg Cys Pro Asn Ser 
    450                 455                 460                 


Cys Val Thr Gly Val Tyr Thr Asp Pro Tyr Pro Leu Ile Phe Tyr Arg 
465                 470                 475                 480 


Asn His Thr Leu Arg Gly Val Phe Gly Thr Met Leu Asp Gly Val Gln 
                485                 490                 495     


Ala Arg Leu Asn Pro Ala Ser Ala Val Phe Asp Ser Thr Ser Arg Ser 
            500                 505                 510         


Arg Ile Thr Arg Val Ser Ser Ser Ser Thr Lys Ala Ala Tyr Thr Thr 
        515                 520                 525             


Ser Thr Cys Phe Lys Val Val Lys Thr Asn Lys Thr Tyr Cys Leu Ser 
    530                 535                 540                 


Ile Ala Glu Ile Ser Asn Thr Leu Phe Gly Glu Phe Arg Ile Val Pro 
545                 550                 555                 560 


Leu Leu Val Glu Ile Leu Lys Asp Asp Gly Val Arg Glu Ala Arg Ser 
                565                 570                 575     


Gly 
    


<210>  106
<211>  574
<212>  PRT
<213>  Human respiratory syncytial virus A2

<400>  106

Met Glu Leu Leu Ile Leu Lys Ala Asn Ala Ile Thr Thr Ile Leu Thr 
1               5                   10                  15      


Ala Val Thr Phe Cys Phe Ala Ser Gly Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          


Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Ser Ala Leu 
        35                  40                  45              


Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  


Lys Glu Asn Lys Cys Asn Gly Thr Asp Ala Lys Val Lys Leu Ile Lys 
65                  70                  75                  80  


Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 
                85                  90                  95      


Met Gln Ser Thr Pro Pro Thr Asn Asn Arg Ala Arg Arg Glu Leu Pro 
            100                 105                 110         


Arg Phe Met Asn Tyr Thr Leu Asn Asn Ala Lys Lys Thr Asn Val Thr 
        115                 120                 125             


Leu Ser Lys Lys Arg Lys Arg Arg Phe Leu Gly Phe Leu Leu Gly Val 
    130                 135                 140                 


Gly Ser Ala Ile Ala Ser Gly Val Ala Val Ser Lys Val Leu His Leu 
145                 150                 155                 160 


Glu Gly Glu Val Asn Lys Ile Lys Ser Ala Leu Leu Ser Thr Asn Lys 
                165                 170                 175     


Ala Val Val Ser Leu Ser Asn Gly Val Ser Val Leu Thr Ser Lys Val 
            180                 185                 190         


Leu Asp Leu Lys Asn Tyr Ile Asp Lys Gln Leu Leu Pro Ile Val Asn 
        195                 200                 205             


Lys Gln Ser Cys Ser Ile Ser Asn Ile Glu Thr Val Ile Glu Phe Gln 
    210                 215                 220                 


Gln Lys Asn Asn Arg Leu Leu Glu Ile Thr Arg Glu Phe Ser Val Asn 
225                 230                 235                 240 


Ala Gly Val Thr Thr Pro Val Ser Thr Tyr Met Leu Thr Asn Ser Glu 
                245                 250                 255     


Leu Leu Ser Leu Ile Asn Asp Met Pro Ile Thr Asn Asp Gln Lys Lys 
            260                 265                 270         


Leu Met Ser Asn Asn Val Gln Ile Val Arg Gln Gln Ser Tyr Ser Ile 
        275                 280                 285             


Met Ser Ile Ile Lys Glu Glu Val Leu Ala Tyr Val Val Gln Leu Pro 
    290                 295                 300                 


Leu Tyr Gly Val Ile Asp Thr Pro Cys Trp Lys Leu His Thr Ser Pro 
305                 310                 315                 320 


Leu Cys Thr Thr Asn Thr Lys Glu Gly Ser Asn Ile Cys Leu Thr Arg 
                325                 330                 335     


Thr Asp Arg Gly Trp Tyr Cys Asp Asn Ala Gly Ser Val Ser Phe Phe 
            340                 345                 350         


Pro Gln Ala Glu Thr Cys Lys Val Gln Ser Asn Arg Val Phe Cys Asp 
        355                 360                 365             


Thr Met Asn Ser Leu Thr Leu Pro Ser Glu Ile Asn Leu Cys Asn Val 
    370                 375                 380                 


Asp Ile Phe Asn Pro Lys Tyr Asp Cys Lys Ile Met Thr Ser Lys Thr 
385                 390                 395                 400 


Asp Val Ser Ser Ser Val Ile Thr Ser Leu Gly Ala Ile Val Ser Cys 
                405                 410                 415     


Tyr Gly Lys Thr Lys Cys Thr Ala Ser Asn Lys Asn Arg Gly Ile Ile 
            420                 425                 430         


Lys Thr Phe Ser Asn Gly Cys Asp Tyr Val Ser Asn Lys Gly Met Asp 
        435                 440                 445             


Thr Val Ser Val Gly Asn Thr Leu Tyr Tyr Val Asn Lys Gln Glu Gly 
    450                 455                 460                 


Lys Ser Leu Tyr Val Lys Gly Glu Pro Ile Ile Asn Phe Tyr Asp Pro 
465                 470                 475                 480 


Leu Val Phe Pro Ser Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Asn 
                485                 490                 495     


Glu Lys Ile Asn Gln Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu 
            500                 505                 510         


Leu His Asn Val Asn Ala Gly Lys Ser Thr Thr Asn Ile Met Ile Thr 
        515                 520                 525             


Thr Ile Ile Ile Val Ile Ile Val Ile Leu Leu Ser Leu Ile Ala Val 
    530                 535                 540                 


Gly Leu Leu Leu Tyr Cys Lys Ala Arg Ser Thr Pro Val Thr Leu Ser 
545                 550                 555                 560 


Lys Asp Gln Leu Ser Gly Ile Asn Asn Ile Ala Phe Ser Asn 
                565                 570                 


<210>  107
<211>  263
<212>  PRT
<213>  "
Bovine respiratory syncytial virus"

<400>  107

Met Ser Asn His Thr His His Pro Lys Phe Lys Thr Leu Lys Arg Ala 
1               5                   10                  15      


Trp Lys Ala Ser Lys Tyr Phe Ile Val Gly Leu Ser Cys Leu Tyr Lys 
            20                  25                  30          


Phe Asn Leu Lys Ser Leu Val Gln Thr Ala Leu Thr Ser Leu Ala Met 
        35                  40                  45              


Ile Thr Leu Thr Ser Leu Val Ile Thr Ala Ile Ile Tyr Ile Ser Val 
    50                  55                  60                  


Gly Asn Ala Lys Ala Lys Pro Thr Ser Lys Pro Thr Thr Gln Gln Thr 
65                  70                  75                  80  


Gln Gln Pro Gln Asn His Thr Pro Leu Leu Pro Thr Glu His Asn His 
                85                  90                  95      


Lys Ser Thr His Thr Ser Thr Gln Ser Thr Thr Leu Ser Gln Pro Pro 
            100                 105                 110         


Asn Ile Asp Thr Thr Ser Gly Thr Thr Tyr Gly His Pro Ile Asn Arg 
        115                 120                 125             


Thr Gln Asn Arg Lys Ile Lys Ser Gln Ser Thr Pro Leu Ala Thr Arg 
    130                 135                 140                 


Lys Leu Pro Ile Asn Pro Leu Glu Ser Asn Pro Pro Glu Asn His Gln 
145                 150                 155                 160 


Asp His Asn Asn Ser Gln Thr Leu Pro His Val Pro Cys Ser Thr Cys 
                165                 170                 175     


Glu Gly Asn Pro Ala Cys Ser Pro Leu Cys Gln Ile Gly Leu Glu Arg 
            180                 185                 190         


Ala Pro Ser Arg Ala Pro Thr Ile Thr Leu Lys Lys Ala Pro Lys Pro 
        195                 200                 205             


Lys Thr Thr Lys Lys Pro Thr Lys Thr Thr Ile Tyr His Arg Thr Ser 
    210                 215                 220                 


Pro Glu Ala Lys Leu Gln Thr Lys Lys Asn Thr Ala Thr Pro Gln Gln 
225                 230                 235                 240 


Gly Ile Leu Ser Ser Pro Glu His Gln Thr Asn Gln Ser Thr Thr Gln 
                245                 250                 255     


Ile Ser Gln His Thr Ser Ile 
            260             


<210>  108
<211>  574
<212>  PRT
<213>  Bovine respiratory syncytial virus

<400>  108

Met Ala Thr Thr Ala Met Arg Met Ile Ile Ser Ile Ile Phe Ile Ser 
1               5                   10                  15      


Thr Tyr Val Thr His Ile Thr Leu Cys Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          


Tyr Gln Ser Thr Cys Ser Ala Val Ser Arg Gly Tyr Leu Ser Ala Leu 
        35                  40                  45              


Arg Thr Gly Trp Tyr Thr Ser Val Val Thr Ile Glu Leu Ser Lys Ile 
    50                  55                  60                  


Gln Lys Asn Val Cys Asn Ser Thr Asp Ser Asn Val Lys Leu Ile Lys 
65                  70                  75                  80  


Gln Glu Leu Glu Arg Tyr Asn Asn Ala Val Val Glu Leu Gln Ser Leu 
                85                  90                  95      


Met Gln Asn Glu Pro Ala Ser Ser Ser Arg Ala Lys Arg Gly Ile Pro 
            100                 105                 110         


Glu Leu Ile His Tyr Lys Arg Asn Ser Thr Lys Lys Phe Tyr Gly Leu 
        115                 120                 125             


Met Gly Lys Lys Arg Lys Arg Arg Phe Leu Gly Phe Leu Leu Gly Ile 
    130                 135                 140                 


Gly Ser Ala Ile Ala Ser Gly Val Ala Val Ser Lys Val Leu His Leu 
145                 150                 155                 160 


Glu Gly Glu Val Asn Lys Ile Lys Asn Ala Leu Leu Ser Thr Asn Lys 
                165                 170                 175     


Ala Val Val Ser Leu Ser Asn Gly Val Ser Val Leu Thr Ser Lys Val 
            180                 185                 190         


Leu Asp Leu Lys Asn Tyr Ile Asp Lys Glu Leu Leu Pro Lys Val Asn 
        195                 200                 205             


Asn His Asp Cys Lys Ile Ser Asn Ile Ala Thr Val Ile Glu Phe Gln 
    210                 215                 220                 


Gln Lys Asn Asn Arg Leu Leu Glu Ile Ala Arg Glu Phe Ser Val Asn 
225                 230                 235                 240 


Ala Gly Ile Thr Thr Pro Leu Ser Thr Tyr Met Leu Thr Asn Ser Glu 
                245                 250                 255     


Leu Leu Ser Leu Ile Asn Asp Met Pro Ile Thr Asn Asp Gln Lys Lys 
            260                 265                 270         


Leu Met Ser Ser Asn Val Gln Ile Val Arg Gln Gln Ser Tyr Ser Ile 
        275                 280                 285             


Met Ser Val Val Lys Glu Glu Val Met Ala Tyr Val Val Gln Leu Pro 
    290                 295                 300                 


Ile Tyr Gly Val Ile Asp Thr Pro Cys Trp Lys Leu His Thr Ser Pro 
305                 310                 315                 320 


Leu Cys Thr Thr Asp Asn Lys Glu Gly Ser Asn Ile Cys Leu Thr Arg 
                325                 330                 335     


Thr Asp Arg Gly Trp Tyr Cys Asp Asn Ala Gly Ser Val Ser Phe Phe 
            340                 345                 350         


Pro Gln Ala Glu Thr Cys Lys Val Gln Ser Asn Arg Val Phe Cys Asp 
        355                 360                 365             


Thr Met Asn Ser Leu Thr Leu Pro Thr Asp Val Asn Leu Cys Asn Thr 
    370                 375                 380                 


Asp Ile Phe Asn Ala Lys Tyr Asp Cys Lys Ile Met Thr Ser Lys Thr 
385                 390                 395                 400 


Asp Ile Ser Ser Ser Val Ile Thr Ser Ile Gly Ala Ile Val Ser Cys 
                405                 410                 415     


Tyr Gly Lys Thr Lys Cys Thr Ala Ser Asn Lys Asn Arg Gly Ile Ile 
            420                 425                 430         


Lys Thr Phe Ser Asn Gly Cys Asp Tyr Val Ser Asn Arg Gly Val Asp 
        435                 440                 445             


Thr Val Ser Val Gly Asn Thr Leu Tyr Tyr Val Asn Lys Leu Glu Gly 
    450                 455                 460                 


Lys Ala Leu Tyr Ile Lys Gly Glu Pro Ile Ile Asn Tyr Tyr Asp Pro 
465                 470                 475                 480 


Leu Val Phe Pro Ser Asp Glu Phe Asp Ala Ser Ile Ala Gln Val Asn 
                485                 490                 495     


Ala Lys Ile Asn Gln Ser Leu Ala Phe Ile Arg Arg Ser Asp Glu Leu 
            500                 505                 510         


Leu His Ser Val Asp Val Gly Lys Ser Thr Thr Asn Val Val Ile Thr 
        515                 520                 525             


Thr Ile Ile Ile Val Ile Val Val Val Ile Leu Met Leu Ile Ala Val 
    530                 535                 540                 


Gly Leu Leu Phe Tyr Ser Lys Thr Arg Ser Thr Pro Ile Met Leu Gly 
545                 550                 555                 560 


Lys Asp Gln Leu Ser Gly Ile Asn Asn Leu Ser Phe Ser Lys 
                565                 570                 


<210>  109
<211>  537
<212>  PRT
<213>  Murine pneumonia virus

<400>  109

Met Ile Pro Gly Arg Ile Phe Leu Val Leu Leu Val Ile Phe Asn Thr 
1               5                   10                  15      


Lys Pro Ile His Pro Asn Thr Leu Thr Glu Lys Tyr Tyr Glu Ser Thr 
            20                  25                  30          


Cys Ser Val Glu Thr Ala Gly Tyr Lys Ser Ala Leu Arg Thr Gly Trp 
        35                  40                  45              


His Met Thr Val Met Ser Ile Lys Leu Ser Gln Ile Asn Ile Glu Ser 
    50                  55                  60                  


Cys Lys Ser Ser Asn Ser Leu Leu Ala His Glu Leu Ala Ile Tyr Ser 
65                  70                  75                  80  


Ser Ala Val Asp Glu Leu Arg Thr Leu Ser Ser Asn Ala Leu Lys Ser 
                85                  90                  95      


Lys Arg Lys Lys Arg Phe Leu Gly Leu Ile Leu Gly Leu Gly Ala Ala 
            100                 105                 110         


Val Thr Ala Gly Val Ala Leu Ala Lys Thr Val Gln Leu Glu Ser Glu 
        115                 120                 125             


Ile Ala Leu Ile Arg Asp Ala Val Arg Asn Thr Asn Glu Ala Val Val 
    130                 135                 140                 


Ser Leu Thr Asn Gly Met Ser Val Leu Ala Lys Val Val Asp Asp Leu 
145                 150                 155                 160 


Lys Asn Phe Ile Ser Lys Glu Leu Leu Pro Lys Ile Asn Arg Val Ser 
                165                 170                 175     


Cys Asp Val His Asp Ile Thr Ala Val Ile Arg Phe Gln Gln Leu Asn 
            180                 185                 190         


Lys Arg Leu Leu Glu Val Ser Arg Glu Phe Ser Ser Asn Ala Gly Leu 
        195                 200                 205             


Thr His Thr Val Ser Ser Phe Met Leu Thr Asp Arg Glu Leu Thr Ser 
    210                 215                 220                 


Ile Val Gly Gly Met Ala Val Ser Ala Gly Gln Lys Glu Ile Met Leu 
225                 230                 235                 240 


Ser Ser Lys Ala Ile Met Arg Arg Asn Gly Leu Ala Ile Leu Ser Ser 
                245                 250                 255     


Val Asn Ala Asp Thr Leu Val Tyr Val Ile Gln Leu Pro Leu Phe Gly 
            260                 265                 270         


Val Met Asp Thr Asp Cys Trp Val Ile Arg Ser Ser Ile Asp Cys His 
        275                 280                 285             


Asn Ile Ala Asp Lys Tyr Ala Cys Leu Ala Arg Ala Asp Asn Gly Trp 
    290                 295                 300                 


Tyr Cys His Asn Ala Gly Ser Leu Ser Tyr Phe Pro Ser Pro Thr Asp 
305                 310                 315                 320 


Cys Glu Ile His Asn Gly Tyr Ala Phe Cys Asp Thr Leu Lys Ser Leu 
                325                 330                 335     


Thr Val Pro Val Thr Ser Arg Glu Cys Asn Ser Asn Met Tyr Thr Thr 
            340                 345                 350         


Asn Tyr Asp Cys Lys Ile Ser Thr Ser Lys Thr Tyr Val Ser Thr Ala 
        355                 360                 365             


Val Leu Thr Thr Met Gly Cys Leu Val Ser Cys Tyr Gly His Asn Ser 
    370                 375                 380                 


Cys Thr Val Ile Asn Asn Asp Lys Gly Ile Ile Arg Thr Leu Pro Asp 
385                 390                 395                 400 


Gly Cys His Tyr Ile Ser Asn Lys Gly Val Asp Arg Val Gln Val Gly 
                405                 410                 415     


Asn Thr Val Tyr Tyr Leu Ser Lys Glu Val Gly Lys Ser Ile Val Val 
            420                 425                 430         


Arg Gly Glu Pro Leu Val Leu Lys Tyr Asp Pro Leu Ser Phe Pro Asp 
        435                 440                 445             


Asp Lys Phe Asp Val Ala Ile Arg Asp Val Glu His Ser Ile Asn Gln 
    450                 455                 460                 


Thr Arg Thr Phe Phe Lys Ala Ser Asp Gln Leu Leu Asp Leu Ser Glu 
465                 470                 475                 480 


Asn Arg Glu Asn Lys Asn Leu Asn Lys Ser Tyr Ile Leu Thr Thr Leu 
                485                 490                 495     


Leu Phe Val Val Met Leu Ile Ile Ile Met Ala Val Ile Gly Phe Ile 
            500                 505                 510         


Leu Tyr Lys Val Leu Lys Met Ile Arg Asp Asn Lys Leu Lys Ser Lys 
        515                 520                 525             


Ser Thr Pro Gly Leu Thr Val Leu Ser 
    530                 535         


<210>  110
<211>  550
<212>  PRT
<213>  Measles virus

<400>  110

Met Gly Leu Lys Val Asn Val Ser Ala Ile Phe Met Ala Val Leu Leu 
1               5                   10                  15      


Thr Leu Gln Thr Pro Thr Gly Gln Ile His Trp Gly Asn Leu Ser Lys 
            20                  25                  30          


Ile Gly Val Val Gly Ile Gly Ser Ala Ser Tyr Lys Val Met Thr Arg 
        35                  40                  45              


Ser Ser His Gln Ser Leu Val Ile Lys Leu Met Pro Asn Ile Thr Leu 
    50                  55                  60                  


Leu Asn Asn Cys Thr Arg Val Glu Ile Ala Glu Tyr Arg Arg Leu Leu 
65                  70                  75                  80  


Arg Thr Val Leu Glu Pro Ile Arg Asp Ala Leu Asn Ala Met Thr Gln 
                85                  90                  95      


Asn Ile Arg Pro Val Gln Ser Val Ala Ser Ser Arg Arg His Lys Arg 
            100                 105                 110         


Phe Ala Gly Val Val Leu Ala Gly Ala Ala Leu Gly Val Ala Thr Ala 
        115                 120                 125             


Ala Gln Ile Thr Ala Gly Ile Ala Leu His Gln Ser Met Leu Asn Ser 
    130                 135                 140                 


Gln Ala Ile Asp Asn Leu Arg Ala Ser Leu Glu Thr Thr Asn Gln Ala 
145                 150                 155                 160 


Ile Glu Ala Ile Arg Gln Ala Gly Gln Glu Met Ile Leu Ala Val Gln 
                165                 170                 175     


Gly Val Gln Asp Tyr Ile Asn Asn Glu Leu Ile Pro Ser Met Asn Gln 
            180                 185                 190         


Leu Ser Cys Asp Leu Ile Gly Gln Lys Leu Gly Leu Lys Leu Leu Arg 
        195                 200                 205             


Tyr Tyr Thr Glu Ile Leu Ser Leu Phe Gly Pro Ser Leu Arg Asp Pro 
    210                 215                 220                 


Ile Ser Ala Glu Ile Ser Ile Gln Ala Leu Ser Tyr Ala Leu Gly Gly 
225                 230                 235                 240 


Asp Ile Asn Lys Val Leu Glu Lys Leu Gly Tyr Ser Gly Gly Asp Leu 
                245                 250                 255     


Leu Gly Ile Leu Glu Ser Arg Gly Ile Lys Ala Arg Ile Thr His Val 
            260                 265                 270         


Asp Thr Glu Ser Tyr Phe Ile Val Leu Ser Ile Ala Tyr Pro Thr Leu 
        275                 280                 285             


Ser Glu Ile Lys Gly Val Ile Val His Arg Leu Glu Gly Val Ser Tyr 
    290                 295                 300                 


Asn Ile Gly Ser Gln Glu Trp Tyr Thr Thr Val Pro Lys Tyr Val Ala 
305                 310                 315                 320 


Thr Gln Gly Tyr Leu Ile Ser Asn Phe Asp Glu Ser Ser Cys Thr Phe 
                325                 330                 335     


Met Pro Glu Gly Thr Val Cys Ser Gln Asn Ala Leu Tyr Pro Met Ser 
            340                 345                 350         


Pro Leu Leu Gln Glu Cys Leu Arg Gly Ser Thr Lys Ser Cys Ala Arg 
        355                 360                 365             


Thr Leu Val Ser Gly Ser Phe Gly Asn Arg Phe Ile Leu Ser Gln Gly 
    370                 375                 380                 


Asn Leu Ile Ala Asn Cys Ala Ser Ile Leu Cys Lys Cys Tyr Thr Thr 
385                 390                 395                 400 


Gly Thr Ile Ile Asn Gln Asp Pro Asp Lys Ile Leu Thr Tyr Ile Ala 
                405                 410                 415     


Ala Asp His Cys Pro Val Val Glu Val Asn Gly Val Thr Ile Gln Val 
            420                 425                 430         


Gly Ser Arg Arg Tyr Pro Asp Ala Val Tyr Leu His Arg Ile Asp Leu 
        435                 440                 445             


Gly Pro Pro Ile Ser Leu Glu Arg Leu Asp Val Gly Thr Asn Leu Gly 
    450                 455                 460                 


Asn Ala Ile Ala Lys Leu Glu Asp Ala Lys Glu Leu Leu Glu Ser Ser 
465                 470                 475                 480 


Asp Gln Ile Leu Arg Ser Met Lys Gly Leu Ser Ser Thr Ser Ile Val 
                485                 490                 495     


Tyr Ile Leu Ile Ala Val Cys Leu Gly Gly Leu Ile Gly Ile Pro Ala 
            500                 505                 510         


Leu Ile Cys Cys Cys Arg Gly Arg Cys Asn Lys Lys Gly Glu Gln Val 
        515                 520                 525             


Gly Met Ser Arg Pro Gly Leu Lys Pro Asp Leu Thr Gly Thr Ser Lys 
    530                 535                 540                 


Ser Tyr Val Arg Ser Leu 
545                 550 


<210>  111
<211>  550
<212>  PRT
<213>  Measles virus

<400>  111

Met Gly Leu Lys Val Asn Val Ser Ala Ile Phe Met Ala Val Leu Leu 
1               5                   10                  15      


Thr Leu Gln Thr Pro Thr Gly Gln Ile His Trp Gly Asn Leu Ser Lys 
            20                  25                  30          


Ile Gly Val Val Gly Ile Gly Ser Ala Ser Tyr Lys Val Met Thr Arg 
        35                  40                  45              


Ser Ser His Gln Ser Leu Val Ile Lys Leu Met Pro Asn Ile Thr Leu 
    50                  55                  60                  


Leu Asn Asn Cys Thr Arg Val Glu Ile Ala Glu Tyr Arg Arg Leu Leu 
65                  70                  75                  80  


Arg Thr Val Leu Glu Pro Ile Arg Asp Ala Leu Asn Ala Met Thr Gln 
                85                  90                  95      


Asn Ile Arg Pro Val Gln Ser Val Ala Ser Ser Arg Arg His Lys Arg 
            100                 105                 110         


Phe Ala Gly Val Val Leu Ala Gly Ala Ala Leu Gly Val Ala Thr Ala 
        115                 120                 125             


Ala Gln Ile Thr Ala Gly Ile Ala Leu His Gln Ser Met Leu Asn Ser 
    130                 135                 140                 


Gln Ala Ile Asp Asn Leu Arg Ala Ser Leu Glu Thr Thr Asn Gln Ala 
145                 150                 155                 160 


Ile Glu Ala Ile Arg Gln Ala Gly Gln Glu Met Ile Leu Ala Val Gln 
                165                 170                 175     


Gly Val Gln Asp Tyr Ile Asn Asn Glu Leu Ile Pro Ser Met Asn Gln 
            180                 185                 190         


Leu Ser Cys Asp Leu Ile Gly Gln Lys Leu Gly Leu Lys Leu Leu Arg 
        195                 200                 205             


Tyr Tyr Thr Glu Ile Leu Ser Leu Phe Gly Pro Ser Leu Arg Asp Pro 
    210                 215                 220                 


Ile Ser Ala Glu Ile Ser Ile Gln Ala Leu Ser Tyr Ala Leu Gly Gly 
225                 230                 235                 240 


Asp Ile Asn Lys Val Leu Glu Lys Leu Gly Tyr Ser Gly Gly Asp Leu 
                245                 250                 255     


Leu Gly Ile Leu Glu Ser Arg Gly Ile Lys Ala Arg Ile Thr His Val 
            260                 265                 270         


Asp Thr Glu Ser Tyr Phe Ile Val Leu Ser Ile Ala Tyr Pro Thr Leu 
        275                 280                 285             


Ser Glu Ile Lys Gly Val Ile Val His Arg Leu Glu Gly Val Ser Tyr 
    290                 295                 300                 


Asn Ile Gly Ser Gln Glu Trp Tyr Thr Thr Val Pro Lys Tyr Val Ala 
305                 310                 315                 320 


Thr Gln Gly Tyr Leu Ile Ser Asn Phe Asp Glu Ser Ser Cys Thr Phe 
                325                 330                 335     


Met Pro Glu Gly Thr Val Cys Ser Gln Asn Ala Leu Tyr Pro Met Ser 
            340                 345                 350         


Pro Leu Leu Gln Glu Cys Leu Arg Gly Ser Thr Lys Ser Cys Ala Arg 
        355                 360                 365             


Thr Leu Val Ser Gly Ser Phe Gly Asn Arg Phe Ile Leu Ser Gln Gly 
    370                 375                 380                 


Asn Leu Ile Ala Asn Cys Ala Ser Ile Leu Cys Lys Cys Tyr Thr Thr 
385                 390                 395                 400 


Gly Thr Ile Ile Asn Gln Asp Pro Asp Lys Ile Leu Thr Tyr Ile Ala 
                405                 410                 415     


Ala Asp His Cys Pro Val Val Glu Val Asn Gly Val Thr Ile Gln Val 
            420                 425                 430         


Gly Ser Arg Arg Tyr Pro Asp Ala Val Tyr Leu His Arg Ile Asp Leu 
        435                 440                 445             


Gly Pro Pro Ile Ser Leu Glu Arg Leu Asp Val Gly Thr Asn Leu Gly 
    450                 455                 460                 


Asn Ala Ile Ala Lys Leu Glu Asp Ala Lys Glu Leu Leu Glu Ser Ser 
465                 470                 475                 480 


Asp Gln Ile Leu Arg Ser Met Lys Gly Leu Ser Ser Thr Ser Ile Val 
                485                 490                 495     


Tyr Ile Leu Ile Ala Val Cys Leu Gly Gly Leu Ile Gly Ile Pro Ala 
            500                 505                 510         


Leu Ile Cys Cys Cys Arg Gly Arg Cys Asn Lys Lys Gly Glu Gln Val 
        515                 520                 525             


Gly Met Ser Arg Pro Gly Leu Lys Pro Asp Leu Thr Gly Thr Ser Lys 
    530                 535                 540                 


Ser Tyr Val Arg Ser Leu 
545                 550 


<210>  112
<211>  574
<212>  PRT
<213>  Human respiratory syncytial virus B

<400>  112

Met Glu Leu Leu Ile His Arg Leu Ser Ala Ile Phe Leu Thr Leu Ala 
1               5                   10                  15      


Ile Asn Ala Leu Tyr Leu Thr Ser Ser Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          


Tyr Gln Ser Thr Cys Ser Ala Val Ser Arg Gly Tyr Phe Ser Ala Leu 
        35                  40                  45              


Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  


Lys Glu Thr Lys Cys Asn Gly Thr Asp Thr Lys Val Lys Leu Ile Lys 
65                  70                  75                  80  


Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 
                85                  90                  95      


Met Gln Asn Thr Pro Ala Ala Asn Asn Arg Ala Arg Arg Glu Ala Pro 
            100                 105                 110         


Gln Tyr Met Asn Tyr Thr Ile Asn Thr Thr Lys Asn Leu Asn Val Ser 
        115                 120                 125             


Ile Ser Lys Lys Arg Lys Arg Arg Phe Leu Gly Phe Leu Leu Gly Val 
    130                 135                 140                 


Gly Ser Ala Ile Ala Ser Gly Ile Ala Val Ser Lys Val Leu His Leu 
145                 150                 155                 160 


Glu Gly Glu Val Asn Lys Ile Lys Asn Ala Leu Leu Ser Thr Asn Lys 
                165                 170                 175     


Ala Val Val Ser Leu Ser Asn Gly Val Ser Val Leu Thr Ser Lys Val 
            180                 185                 190         


Leu Asp Leu Lys Asn Tyr Ile Asn Asn Gln Leu Leu Pro Ile Val Asn 
        195                 200                 205             


Gln Gln Ser Cys Arg Ile Ser Asn Ile Glu Thr Val Ile Glu Phe Gln 
    210                 215                 220                 


Gln Lys Asn Ser Arg Leu Leu Glu Ile Asn Arg Glu Phe Ser Val Asn 
225                 230                 235                 240 


Ala Gly Val Thr Thr Pro Leu Ser Thr Tyr Met Leu Thr Asn Ser Glu 
                245                 250                 255     


Leu Leu Ser Leu Ile Asn Asp Met Pro Ile Thr Asn Asp Gln Lys Lys 
            260                 265                 270         


Leu Met Ser Ser Asn Val Gln Ile Val Arg Gln Gln Ser Tyr Ser Ile 
        275                 280                 285             


Met Ser Ile Ile Lys Glu Glu Val Leu Ala Tyr Val Val Gln Leu Pro 
    290                 295                 300                 


Ile Tyr Gly Val Ile Asp Thr Pro Cys Trp Lys Leu His Thr Ser Pro 
305                 310                 315                 320 


Leu Cys Thr Thr Asn Ile Lys Glu Gly Ser Asn Ile Cys Leu Thr Arg 
                325                 330                 335     


Thr Asp Arg Gly Trp Tyr Cys Asp Asn Ala Gly Ser Val Ser Phe Phe 
            340                 345                 350         


Pro Gln Ala Asp Thr Cys Lys Val Gln Ser Asn Arg Val Phe Cys Asp 
        355                 360                 365             


Thr Met Asn Ser Leu Thr Leu Pro Ser Glu Val Ser Leu Cys Asn Thr 
    370                 375                 380                 


Asp Ile Phe Asn Ser Lys Tyr Asp Cys Lys Ile Met Thr Ser Lys Thr 
385                 390                 395                 400 


Asp Ile Ser Ser Ser Val Ile Thr Ser Leu Gly Ala Ile Val Ser Cys 
                405                 410                 415     


Tyr Gly Lys Thr Lys Cys Thr Ala Ser Asn Lys Asn Arg Gly Ile Ile 
            420                 425                 430         


Lys Thr Phe Ser Asn Gly Cys Asp Tyr Val Ser Asn Lys Gly Val Asp 
        435                 440                 445             


Thr Val Ser Val Gly Asn Thr Leu Tyr Tyr Val Asn Lys Leu Glu Gly 
    450                 455                 460                 


Lys Asn Leu Tyr Val Lys Gly Glu Pro Ile Ile Asn Tyr Tyr Asp Pro 
465                 470                 475                 480 


Leu Val Phe Pro Ser Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Asn 
                485                 490                 495     


Glu Lys Ile Asn Gln Ser Leu Ala Phe Ile Arg Arg Ser Asp Glu Leu 
            500                 505                 510         


Leu His Asn Val Asn Thr Gly Lys Ser Thr Thr Asn Ile Met Ile Thr 
        515                 520                 525             


Thr Ile Ile Ile Val Ile Ile Val Val Leu Leu Ser Leu Ile Ala Ile 
    530                 535                 540                 


Gly Leu Leu Leu Tyr Cys Lys Ala Lys Asn Thr Pro Val Thr Leu Ser 
545                 550                 555                 560 


Lys Asp Gln Leu Ser Gly Ile Asn Asn Ile Ala Phe Ser Lys 
                565                 570                 


<210>  113
<211>  546
<212>  PRT
<213>  Rinderpest virus

<400>  113

Met Lys Ile Leu Phe Ala Thr Leu Leu Val Val Thr Thr Pro His Leu 
1               5                   10                  15      


Val Thr Gly Gln Ile His Trp Gly Asn Leu Ser Lys Ile Gly Val Val 
            20                  25                  30          


Gly Thr Gly Ser Ala Ser Tyr Lys Val Met Thr Gln Ser Ser His Gln 
        35                  40                  45              


Thr Leu Val Ile Lys Leu Met Pro Asn Ile Thr Ala Ile Asp Asn Cys 
    50                  55                  60                  


Thr Lys Thr Glu Ile Glu Glu Tyr Lys Arg Leu Leu Gly Thr Val Leu 
65                  70                  75                  80  


Gln Pro Ile Lys Val Ala Leu Asn Ala Ile Thr Lys Asn Ile Lys Pro 
                85                  90                  95      


Ile Lys Ser Ser Thr Thr Ser Arg Arg His Arg Arg Phe Ala Gly Val 
            100                 105                 110         


Ala Leu Ala Gly Ala Ala Leu Gly Val Ala Thr Ala Ala Gln Ile Thr 
        115                 120                 125             


Ala Gly Ile Ala Leu His Gln Ser Met Met Asn Thr Gln Ala Ile Glu 
    130                 135                 140                 


Ser Leu Lys Ala Ser Leu Glu Thr Thr Asn Gln Ala Ile Glu Glu Ile 
145                 150                 155                 160 


Arg Gln Ala Gly Gln Glu Met Ile Leu Ala Val Gln Gly Val Gln Asp 
                165                 170                 175     


Tyr Ile Asn Asn Glu Leu Val Pro Ala Met Gly Gln Leu Ser Cys Asp 
            180                 185                 190         


Ile Val Gly Gln Lys Leu Gly Leu Lys Leu Leu Arg Tyr Tyr Thr Glu 
        195                 200                 205             


Ile Leu Ser Leu Phe Gly Pro Ser Leu Arg Asp Pro Ile Ser Ala Glu 
    210                 215                 220                 


Ile Ser Ile Gln Ala Leu Ser Tyr Ala Leu Gly Gly Asp Ile Asn Lys 
225                 230                 235                 240 


Ile Leu Glu Lys Leu Gly Tyr Ser Gly Ser Asp Leu Leu Ala Ile Leu 
                245                 250                 255     


Glu Ser Lys Gly Ile Lys Ala Lys Ile Thr Tyr Val Asp Ile Glu Ser 
            260                 265                 270         


Tyr Phe Ile Val Leu Ser Ile Ala Tyr Pro Ser Leu Ser Glu Ile Lys 
        275                 280                 285             


Gly Val Ile Ile His Arg Leu Glu Gly Val Ser Tyr Asn Ile Gly Ser 
    290                 295                 300                 


Gln Glu Trp Tyr Thr Thr Val Pro Arg Tyr Val Ala Thr Gln Gly Tyr 
305                 310                 315                 320 


Leu Ile Ser Asn Phe Asp Asp Thr Pro Cys Ala Phe Ser Pro Glu Gly 
                325                 330                 335     


Thr Ile Cys Ser Gln Asn Ala Leu Tyr Pro Met Ser Pro Leu Leu Gln 
            340                 345                 350         


Glu Cys Phe Arg Gly Ser Thr Arg Ser Cys Ala Arg Thr Leu Val Ser 
        355                 360                 365             


Gly Ser Ile Gly Asn Arg Phe Ile Leu Ser Lys Gly Asn Leu Ile Ala 
    370                 375                 380                 


Asn Cys Ala Ser Ile Leu Cys Lys Cys Tyr Thr Thr Gly Ser Ile Ile 
385                 390                 395                 400 


Ser Gln Asp Pro Asp Lys Ile Leu Thr Tyr Ile Ala Ala Asp Gln Cys 
                405                 410                 415     


Pro Ile Val Glu Val Asp Gly Val Thr Ile Gln Val Gly Ser Arg Glu 
            420                 425                 430         


Tyr Pro Asp Ala Val Tyr Leu His Lys Ile Asp Leu Gly Pro Pro Ile 
        435                 440                 445             


Ser Leu Glu Lys Leu Asp Val Gly Thr Asn Leu Gly Asn Ala Val Thr 
    450                 455                 460                 


Lys Leu Glu Lys Ala Lys Asp Leu Leu Asp Ser Ser Asp Leu Ile Leu 
465                 470                 475                 480 


Glu Thr Ile Lys Gly Ala Ser Val Thr Asn Thr Gly His Ile Leu Val 
                485                 490                 495     


Gly Ala Gly Leu Ile Ala Val Val Gly Ile Leu Ile Val Thr Cys Cys 
            500                 505                 510         


Cys Arg Lys Arg Ser Asn Asp Ser Lys Val Ser Thr Val Ile Leu Asn 
        515                 520                 525             


Pro Gly Leu Lys Pro Asp Leu Thr Gly Thr Ser Lys Ser Tyr Val Arg 
    530                 535                 540                 


Ser Leu 
545     


<210>  114
<211>  561
<212>  PRT
<213>  Simian virus 41

<400>  114

Met Arg Leu Thr Pro Tyr Pro Ile Ala Leu Thr Thr Leu Met Ile Ala 
1               5                   10                  15      


Leu Thr Thr Leu Pro Glu Thr Gly Leu Gly Ile Ala Arg Asp Ala Leu 
            20                  25                  30          


Ser Gln Val Gly Val Ile Gln Ser Lys Ala Arg Ser Leu Met Tyr Tyr 
        35                  40                  45              


Ser Asp Gly Ser Ser Ser Phe Ile Val Val Lys Leu Leu Pro Thr Leu 
    50                  55                  60                  


Pro Thr Pro Ser Gly Asn Cys Asn Leu Thr Ser Ile Thr Ala Tyr Asn 
65                  70                  75                  80  


Thr Thr Leu Phe Lys Leu Leu Thr Pro Leu Met Glu Asn Leu Asp Thr 
                85                  90                  95      


Ile Val Ser Ala Asn Gln Ala Gly Ser Arg Arg Lys Arg Phe Ala Gly 
            100                 105                 110         


Val Val Val Gly Leu Ala Ala Leu Gly Val Ala Thr Ala Ala Gln Val 
        115                 120                 125             


Thr Ala Ala Val Ala Val Val Lys Ala Asn Ala Asn Ala Ala Ala Ile 
    130                 135                 140                 


Asn Lys Leu Ala Ala Ser Ile Gln Ser Thr Asn Ala Ala Ile Ser Asp 
145                 150                 155                 160 


Val Ile Ser Ser Thr Arg Thr Leu Ala Thr Ala Ile Gln Ala Val Gln 
                165                 170                 175     


Asp His Val Asn Gly Val Leu Ala Ser Gly Leu Thr Glu Ala Asn Cys 
            180                 185                 190         


Arg Ser Gln Asp Ala Leu Ile Gly Ser Ile Leu Asn Leu Tyr Leu Thr 
        195                 200                 205             


Glu Leu Thr Thr Ile Phe His Asn Gln Ile Val Asn Pro Ala Leu Thr 
    210                 215                 220                 


Pro Leu Ser Ile Gln Ala Leu Arg Ile Ile Leu Gly Ser Thr Leu Pro 
225                 230                 235                 240 


Leu Ile Val Glu Ser Arg Trp Asn Thr Asn Leu Asn Thr Ala Glu Leu 
                245                 250                 255     


Leu Ser Ser Gly Leu Leu Thr Gly Gln Ile Ile Ser Ile Ser Pro Ser 
            260                 265                 270         


Tyr Met Gln Met Val Ile Gln Ile Thr Val Pro Thr Phe Val Met Gln 
        275                 280                 285             


Pro Gly Ala Lys Ile Ile Asp Leu Val Thr Ile Thr Ala Asn Arg Met 
    290                 295                 300                 


Glu Glu Glu Val Leu Ile Gln Val Pro Pro Arg Ile Leu Glu Tyr Ala 
305                 310                 315                 320 


Asn Glu Ile Gln Ala Tyr Thr Ala Asp Asp Cys Val Val Thr Pro His 
                325                 330                 335     


Ala Val Phe Cys Lys Tyr Asn Asp Gly Ser Pro Ile Ser Asp Ser Leu 
            340                 345                 350         


Tyr Gln Cys Leu Lys Gly Asn Leu Thr Ser Cys Val Phe Thr Pro Val 
        355                 360                 365             


Val Gly Asn Tyr Leu Lys Arg Phe Ala Phe Ala Asn Gly Val Met Tyr 
    370                 375                 380                 


Val Asn Cys Lys Ala Leu Leu Cys Arg Cys Ala Asp Pro Pro Met Val 
385                 390                 395                 400 


Ile Thr Gln Asp Asp Leu Ala Gly Ile Thr Val Ile Asp Ile Thr Val 
                405                 410                 415     


Cys Arg Glu Val Met Leu Asp Thr Leu Ala Phe Lys Ile Thr Ser Leu 
            420                 425                 430         


Asn Asn Val Thr Tyr Gly Ala Asn Phe Ser Met Leu Ala Ala Ala Ile 
        435                 440                 445             


Lys Asp Leu Ser Pro Leu Asp Leu Ser Ala Gln Leu Ala Gln Val Asn 
    450                 455                 460                 


Lys Ser Leu Ala Ser Ala Glu Glu Lys Ile Ala Gln Ser Ser Ser Leu 
465                 470                 475                 480 


Ala Ala Gln Ala Val Ser Gln Glu Ala Thr Ile Thr Val Gly Ser Val 
                485                 490                 495     


Ala Met Leu Ile Ala Val Leu Ala Leu Ile Ala Gly Cys Thr Gly Ile 
            500                 505                 510         


Met Ile Ala Val Gln Met Ser Arg Arg Leu Glu Val Leu Arg His Leu 
        515                 520                 525             


Thr Asp Gln Ser Ile Ile Ser Asn His His Tyr Ala Glu Leu Asn Pro 
    530                 535                 540                 


Pro Pro Tyr Asn His Ser Tyr Glu Ser Leu His Pro Ile Pro Gln Ser 
545                 550                 555                 560 


His 
    


<210>  115
<211>  538
<212>  PRT
<213>  Mumps virus

<400>  115

Met Lys Val Phe Leu Val Thr Cys Leu Gly Phe Ala Val Phe Ser Ser 
1               5                   10                  15      


Ser Val Cys Val Asn Ile Asn Ile Leu Gln Gln Ile Gly Tyr Ile Lys 
            20                  25                  30          


Gln Gln Val Arg Gln Leu Ser Tyr Tyr Ser Gln Ser Ser Ser Ser Tyr 
        35                  40                  45              


Ile Val Val Lys Leu Leu Pro Asn Ile Gln Pro Thr Asp Asn Ser Cys 
    50                  55                  60                  


Glu Phe Lys Ser Val Thr Gln Tyr Asn Lys Thr Leu Ser Asn Leu Leu 
65                  70                  75                  80  


Leu Pro Ile Ala Glu Asn Ile Asn Asn Ile Ala Ser Pro Ser Ser Gly 
                85                  90                  95      


Ser Arg Arg His Lys Arg Phe Ala Gly Ile Ala Ile Gly Ile Ala Ala 
            100                 105                 110         


Leu Gly Val Ala Thr Ala Ala Gln Val Thr Ala Ala Val Ser Leu Val 
        115                 120                 125             


Gln Ala Gln Thr Asn Ala Arg Ala Ile Ala Ala Met Lys Asn Ser Ile 
    130                 135                 140                 


Gln Ala Thr Asn Arg Ala Val Phe Glu Val Lys Glu Gly Thr Gln Arg 
145                 150                 155                 160 


Leu Ala Ile Ala Val Gln Ala Ile Gln Asp His Ile Asn Thr Ile Met 
                165                 170                 175     


Asn Thr Gln Leu Asn Asn Met Ser Cys Gln Ile Leu Asp Asn Gln Leu 
            180                 185                 190         


Ala Thr Ser Leu Gly Leu Tyr Leu Thr Glu Leu Thr Thr Val Phe Gln 
        195                 200                 205             


Pro Gln Leu Ile Asn Pro Ala Leu Ser Pro Ile Ser Ile Gln Ala Leu 
    210                 215                 220                 


Arg Ser Leu Leu Gly Ser Met Thr Pro Ala Val Val Gln Ala Thr Leu 
225                 230                 235                 240 


Ser Thr Ser Ile Ser Ala Ala Glu Ile Leu Ser Ala Gly Leu Met Glu 
                245                 250                 255     


Gly Gln Ile Val Ser Val Leu Leu Asp Glu Met Gln Met Ile Val Lys 
            260                 265                 270         


Ile Asn Ile Pro Thr Ile Val Thr Gln Ser Asn Ala Leu Val Ile Asp 
        275                 280                 285             


Phe Tyr Ser Ile Ser Ser Phe Ile Asn Asn Gln Glu Ser Ile Ile Gln 
    290                 295                 300                 


Leu Pro Asp Arg Ile Leu Glu Ile Gly Asn Glu Gln Trp Ser Tyr Pro 
305                 310                 315                 320 


Ala Lys Asn Cys Lys Leu Thr Arg His His Ile Phe Cys Gln Tyr Asn 
                325                 330                 335     


Glu Ala Glu Arg Leu Ser Leu Glu Ser Lys Leu Cys Leu Ala Gly Asn 
            340                 345                 350         


Ile Ser Ala Cys Val Phe Ser Pro Ile Ala Gly Ser Tyr Met Arg Arg 
        355                 360                 365             


Phe Val Ala Leu Asp Gly Thr Ile Val Ala Asn Cys Arg Ser Leu Thr 
    370                 375                 380                 


Cys Leu Cys Lys Ser Pro Ser Tyr Pro Ile Tyr Gln Pro Asp His His 
385                 390                 395                 400 


Ala Val Thr Thr Ile Asp Leu Thr Ala Cys Gln Thr Leu Ser Leu Asp 
                405                 410                 415     


Gly Leu Asp Phe Ser Ile Val Ser Leu Ser Asn Ile Thr Tyr Ala Glu 
            420                 425                 430         


Asn Leu Thr Ile Ser Leu Ser Gln Thr Ile Asn Thr Gln Pro Ile Asp 
        435                 440                 445             


Ile Ser Thr Glu Leu Ser Lys Val Asn Ala Ser Leu Gln Asn Ala Val 
    450                 455                 460                 


Lys Tyr Ile Lys Glu Ser Asn His Gln Leu Gln Ser Val Asn Val Asn 
465                 470                 475                 480 


Ser Lys Ile Gly Ala Ile Ile Val Ala Ala Leu Val Leu Ser Ile Leu 
                485                 490                 495     


Ser Ile Ile Ile Ser Leu Leu Phe Cys Cys Trp Ala Tyr Val Ala Thr 
            500                 505                 510         


Lys Glu Ile Arg Arg Ile Asn Phe Lys Thr Asn His Ile Asn Thr Ile 
        515                 520                 525             


Ser Ser Ser Val Asp Asp Leu Ile Arg Tyr 
    530                 535             


<210>  116
<211>  662
<212>  PRT
<213>  Canine distemper virus

<400>  116

Met His Arg Gly Ile Pro Lys Ser Ser Lys Thr Gln Thr His Thr Gln 
1               5                   10                  15      


Gln Asp Arg Pro Pro Gln Pro Ser Thr Glu Leu Glu Glu Thr Arg Thr 
            20                  25                  30          


Ser Arg Ala Arg His Ser Thr Thr Ser Ala Gln Arg Ser Thr His Tyr 
        35                  40                  45              


Asp Pro Arg Thr Ser Asp Arg Pro Val Ser Tyr Thr Met Asn Arg Thr 
    50                  55                  60                  


Arg Ser Arg Lys Gln Thr Ser His Arg Leu Lys Asn Ile Pro Val His 
65                  70                  75                  80  


Gly Asn His Glu Ala Thr Ile Gln His Ile Pro Glu Ser Val Ser Lys 
                85                  90                  95      


Gly Ala Arg Ser Gln Ile Glu Arg Arg Gln Pro Asn Ala Ile Asn Ser 
            100                 105                 110         


Gly Ser His Cys Thr Trp Leu Val Leu Trp Cys Leu Gly Met Ala Ser 
        115                 120                 125             


Leu Phe Leu Cys Ser Lys Ala Gln Ile His Trp Asp Asn Leu Ser Thr 
    130                 135                 140                 


Ile Gly Ile Ile Gly Thr Asp Asn Val His Tyr Lys Ile Met Thr Arg 
145                 150                 155                 160 


Pro Ser His Gln Tyr Leu Val Ile Lys Leu Ile Pro Asn Ala Ser Leu 
                165                 170                 175     


Ile Glu Asn Cys Thr Lys Ala Glu Leu Gly Glu Tyr Glu Lys Leu Leu 
            180                 185                 190         


Asn Ser Val Leu Glu Pro Ile Asn Gln Ala Leu Thr Leu Met Thr Lys 
        195                 200                 205             


Asn Val Lys Pro Leu Gln Ser Leu Gly Ser Gly Arg Arg Gln Arg Arg 
    210                 215                 220                 


Phe Ala Gly Val Val Leu Ala Gly Val Ala Leu Gly Val Ala Thr Ala 
225                 230                 235                 240 


Ala Gln Ile Thr Ala Gly Ile Ala Leu His Gln Ser Asn Leu Asn Ala 
                245                 250                 255     


Gln Ala Ile Gln Ser Leu Arg Thr Ser Leu Glu Gln Ser Asn Lys Ala 
            260                 265                 270         


Ile Glu Glu Ile Arg Glu Ala Thr Gln Glu Thr Val Ile Ala Val Gln 
        275                 280                 285             


Gly Val Gln Asp Tyr Val Asn Asn Glu Leu Val Pro Ala Met Gln His 
    290                 295                 300                 


Met Ser Cys Glu Leu Val Gly Gln Arg Leu Gly Leu Arg Leu Leu Arg 
305                 310                 315                 320 


Tyr Tyr Thr Glu Leu Leu Ser Ile Phe Gly Pro Ser Leu Arg Asp Pro 
                325                 330                 335     


Ile Ser Ala Glu Ile Ser Ile Gln Ala Leu Ile Tyr Ala Leu Gly Gly 
            340                 345                 350         


Glu Ile His Lys Ile Leu Glu Lys Leu Gly Tyr Ser Gly Ser Asp Met 
        355                 360                 365             


Ile Ala Ile Leu Glu Ser Arg Gly Ile Lys Thr Lys Ile Thr His Val 
    370                 375                 380                 


Asp Leu Pro Gly Lys Phe Ile Ile Leu Ser Ile Ser Tyr Pro Thr Leu 
385                 390                 395                 400 


Ser Glu Val Lys Gly Val Ile Val His Arg Leu Glu Ala Val Ser Tyr 
                405                 410                 415     


Asn Ile Gly Ser Gln Glu Trp Tyr Thr Thr Val Pro Arg Tyr Ile Ala 
            420                 425                 430         


Thr Asn Gly Tyr Leu Ile Ser Asn Phe Asp Glu Ser Ser Cys Val Phe 
        435                 440                 445             


Val Ser Glu Ser Ala Ile Cys Ser Gln Asn Ser Leu Tyr Pro Met Ser 
    450                 455                 460                 


Pro Leu Leu Gln Gln Cys Ile Arg Gly Asp Thr Ser Ser Cys Ala Arg 
465                 470                 475                 480 


Thr Leu Val Ser Gly Thr Met Gly Asn Lys Phe Ile Leu Ser Lys Gly 
                485                 490                 495     


Asn Ile Val Ala Asn Cys Ala Ser Ile Leu Cys Lys Cys Tyr Ser Thr 
            500                 505                 510         


Ser Thr Ile Ile Asn Gln Ser Pro Asp Lys Leu Leu Thr Phe Ile Ala 
        515                 520                 525             


Ser Asp Thr Cys Pro Leu Val Glu Ile Asp Gly Ala Thr Ile Gln Val 
    530                 535                 540                 


Gly Gly Arg Gln Tyr Pro Asp Met Val Tyr Glu Gly Lys Val Ala Leu 
545                 550                 555                 560 


Gly Pro Ala Ile Ser Leu Asp Arg Leu Asp Val Gly Thr Asn Leu Gly 
                565                 570                 575     


Asn Ala Leu Lys Lys Leu Asp Asp Ala Lys Val Leu Ile Asp Ser Ser 
            580                 585                 590         


Asn Gln Ile Leu Glu Thr Val Arg Arg Ser Ser Phe Asn Phe Gly Ser 
        595                 600                 605             


Leu Leu Ser Val Pro Ile Leu Ser Cys Thr Ala Leu Ala Leu Leu Leu 
    610                 615                 620                 


Leu Ile Tyr Cys Cys Lys Arg Arg Tyr Gln Gln Thr Leu Lys Gln His 
625                 630                 635                 640 


Thr Lys Val Asp Pro Ala Phe Lys Pro Asp Leu Thr Gly Thr Ser Lys 
                645                 650                 655     


Ser Tyr Val Arg Ser Leu 
            660         


<210>  117
<211>  574
<212>  PRT
<213>  Human respiratory syncytial virus A

<400>  117

Met Glu Leu Pro Ile Leu Lys Ala Asn Ala Ile Thr Thr Ile Leu Ala 
1               5                   10                  15      


Ala Val Thr Phe Cys Phe Ala Ser Ser Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          


Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Ser Ala Leu 
        35                  40                  45              


Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  


Lys Glu Asn Lys Cys Asn Gly Thr Asp Ala Lys Val Lys Leu Ile Lys 
65                  70                  75                  80  


Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 
                85                  90                  95      


Met Gln Ser Thr Pro Ala Ala Asn Asn Arg Ala Arg Arg Glu Leu Pro 
            100                 105                 110         


Arg Phe Met Asn Tyr Thr Leu Asn Asn Thr Lys Lys Thr Asn Val Thr 
        115                 120                 125             


Leu Ser Lys Lys Arg Lys Arg Arg Phe Leu Gly Phe Leu Leu Gly Val 
    130                 135                 140                 


Gly Ser Ala Ile Ala Ser Gly Thr Ala Val Ser Lys Val Leu His Leu 
145                 150                 155                 160 


Glu Gly Glu Val Asn Lys Ile Lys Ser Ala Leu Leu Ser Thr Asn Lys 
                165                 170                 175     


Ala Val Val Ser Leu Ser Asn Gly Val Ser Val Leu Thr Ser Lys Val 
            180                 185                 190         


Leu Asp Leu Lys Asn Tyr Ile Asp Lys Gln Leu Leu Pro Ile Val Asn 
        195                 200                 205             


Lys Gln Ser Cys Arg Ile Ser Asn Ile Glu Thr Val Ile Glu Phe Gln 
    210                 215                 220                 


Gln Lys Asn Asn Arg Leu Leu Glu Ile Thr Arg Glu Phe Ser Val Asn 
225                 230                 235                 240 


Ala Gly Val Thr Thr Pro Val Ser Thr Tyr Met Leu Thr Asn Ser Glu 
                245                 250                 255     


Leu Leu Ser Leu Ile Asn Asp Met Pro Ile Thr Asn Asp Gln Lys Lys 
            260                 265                 270         


Leu Met Ser Asn Asn Val Gln Ile Val Arg Gln Gln Ser Tyr Ser Ile 
        275                 280                 285             


Met Ser Ile Ile Lys Glu Glu Val Leu Ala Tyr Val Val Gln Leu Pro 
    290                 295                 300                 


Leu Tyr Gly Val Ile Asp Thr Pro Cys Trp Lys Leu His Thr Ser Pro 
305                 310                 315                 320 


Leu Cys Thr Thr Asn Thr Lys Glu Gly Ser Asn Ile Cys Leu Thr Arg 
                325                 330                 335     


Thr Asp Arg Gly Trp Tyr Cys Asp Asn Ala Gly Ser Val Ser Phe Phe 
            340                 345                 350         


Pro Gln Ala Glu Thr Cys Lys Val Gln Ser Asn Arg Val Phe Cys Asp 
        355                 360                 365             


Thr Met Asn Ser Leu Thr Leu Pro Ser Glu Val Asn Leu Cys Asn Val 
    370                 375                 380                 


Asp Ile Phe Asn Pro Lys Tyr Asp Cys Lys Ile Met Thr Ser Lys Thr 
385                 390                 395                 400 


Asp Val Ser Ser Ser Val Ile Thr Ser Leu Gly Ala Ile Val Ser Cys 
                405                 410                 415     


Tyr Gly Lys Thr Lys Cys Thr Ala Ser Asn Lys Asn Arg Gly Ile Ile 
            420                 425                 430         


Lys Thr Phe Ser Asn Gly Cys Asp Tyr Ala Ser Asn Lys Gly Val Asp 
        435                 440                 445             


Thr Val Ser Val Gly Asn Thr Leu Tyr Tyr Val Asn Lys Gln Glu Gly 
    450                 455                 460                 


Lys Ser Leu Tyr Val Lys Gly Glu Pro Ile Ile Asn Phe Tyr Asp Pro 
465                 470                 475                 480 


Leu Val Phe Pro Ser Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Asn 
                485                 490                 495     


Glu Lys Ile Asn Gln Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu 
            500                 505                 510         


Leu His His Val Asn Ala Gly Lys Ser Thr Thr Asn Ile Met Ile Thr 
        515                 520                 525             


Thr Ile Ile Ile Val Ile Ile Val Ile Leu Leu Ser Leu Ile Ala Val 
    530                 535                 540                 


Gly Leu Leu Leu Tyr Cys Lys Ala Arg Ser Thr Pro Val Thr Leu Ser 
545                 550                 555                 560 


Lys Asp Gln Leu Ser Gly Ile Asn Asn Ile Ala Phe Ser Asn 
                565                 570                 


<210>  118
<211>  565
<212>  PRT
<213>  Sendai virus

<400>  118

Met Thr Ala Tyr Ile Gln Arg Ser Gln Cys Ile Ser Thr Ser Leu Leu 
1               5                   10                  15      


Val Val Leu Thr Thr Leu Val Ser Cys Gln Ile Pro Arg Asp Arg Leu 
            20                  25                  30          


Ser Asn Ile Gly Val Ile Val Asp Glu Gly Lys Ser Leu Lys Ile Ala 
        35                  40                  45              


Gly Ser His Glu Ser Arg Tyr Ile Val Leu Ser Leu Val Pro Gly Val 
    50                  55                  60                  


Asp Leu Glu Asn Gly Cys Gly Thr Ala Gln Val Ile Gln Tyr Lys Ser 
65                  70                  75                  80  


Leu Leu Asn Arg Leu Leu Ile Pro Leu Arg Asp Ala Leu Asp Leu Gln 
                85                  90                  95      


Glu Ala Leu Ile Thr Val Thr Asn Asp Thr Thr Gln Asn Ala Gly Val 
            100                 105                 110         


Pro Gln Ser Arg Phe Phe Gly Ala Val Ile Gly Thr Ile Ala Leu Gly 
        115                 120                 125             


Val Ala Thr Ser Ala Gln Ile Thr Ala Gly Ile Ala Leu Ala Glu Ala 
    130                 135                 140                 


Arg Glu Ala Lys Arg Asp Ile Ala Leu Ile Lys Glu Ser Met Thr Lys 
145                 150                 155                 160 


Thr His Lys Ser Ile Glu Leu Leu Gln Asn Ala Val Gly Glu Gln Ile 
                165                 170                 175     


Leu Ala Leu Lys Thr Leu Gln Asp Phe Val Asn Asp Glu Ile Lys Pro 
            180                 185                 190         


Ala Ile Ser Glu Leu Gly Cys Glu Thr Ala Ala Leu Arg Leu Gly Ile 
        195                 200                 205             


Lys Leu Thr Gln His Tyr Ser Gly Leu Leu Thr Ala Phe Gly Ser Asn 
    210                 215                 220                 


Phe Gly Thr Ile Gly Glu Lys Ser Leu Thr Leu Gln Ala Leu Ser Ser 
225                 230                 235                 240 


Leu Tyr Ser Ala Asn Ile Thr Glu Ile Met Thr Thr Ile Arg Thr Gly 
                245                 250                 255     


Gln Ser Asn Ile Tyr Asp Val Ile Tyr Thr Glu Gln Ile Lys Gly Thr 
            260                 265                 270         


Val Ile Asp Val Asp Leu Glu Arg Tyr Met Val Thr Leu Ser Val Lys 
        275                 280                 285             


Ile Pro Ile Leu Ser Glu Val Pro Gly Val Leu Ile His Lys Ala Ser 
    290                 295                 300                 


Ser Ile Ser Tyr Asn Ile Asp Gly Glu Glu Trp Tyr Val Thr Val Pro 
305                 310                 315                 320 


Ser His Ile Leu Ser Arg Ala Ser Phe Leu Gly Gly Ala Asp Ile Thr 
                325                 330                 335     


Asp Cys Val Glu Ser Arg Leu Thr Tyr Ile Cys Pro Arg Asp Pro Ala 
            340                 345                 350         


Gln Leu Ile Pro Asp Ser Gln Gln Lys Cys Ile Leu Gly Asp Thr Thr 
        355                 360                 365             


Arg Cys Pro Val Thr Lys Val Val Asp Ser Leu Ile Pro Lys Phe Ala 
    370                 375                 380                 


Phe Val Asn Gly Gly Val Val Ala Asn Cys Ile Ala Ser Thr Cys Thr 
385                 390                 395                 400 


Cys Gly Thr Gly Arg Arg Pro Ile Ser Gln Asp Arg Ser Lys Gly Val 
                405                 410                 415     


Val Phe Leu Thr His Asp Asn Cys Gly Leu Ile Gly Val Asn Gly Val 
            420                 425                 430         


Glu Leu Tyr Ala Asn Arg Arg Gly His Asp Ala Thr Trp Gly Val Gln 
        435                 440                 445             


Asn Leu Thr Val Gly Pro Ala Ile Ala Ile Arg Pro Ile Asp Ile Ser 
    450                 455                 460                 


Leu Asn Leu Ala Asp Ala Thr Asn Phe Leu Gln Asp Ser Lys Ala Glu 
465                 470                 475                 480 


Leu Glu Lys Ala Arg Lys Ile Leu Ser Glu Val Gly Arg Trp Tyr Asn 
                485                 490                 495     


Ser Arg Glu Thr Val Ile Thr Ile Ile Val Val Met Val Val Ile Leu 
            500                 505                 510         


Val Val Ile Ile Val Ile Val Ile Val Leu Tyr Arg Leu Lys Arg Ser 
        515                 520                 525             


Met Leu Met Gly Asn Pro Asp Asp Arg Ile Pro Arg Asp Thr Tyr Thr 
    530                 535                 540                 


Leu Glu Pro Lys Ile Arg His Met Tyr Thr Asn Gly Gly Phe Asp Ala 
545                 550                 555                 560 


Met Ala Glu Lys Arg 
                565 


<210>  119
<211>  574
<212>  PRT
<213>  Human respiratory syncytial virus A

<400>  119

Met Glu Leu Pro Ile Leu Lys Thr Asn Ala Ile Thr Ala Ile Leu Ala 
1               5                   10                  15      


Ala Val Thr Leu Cys Phe Ala Ser Ser Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          


Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Ser Ala Leu 
        35                  40                  45              


Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  


Lys Glu Asn Lys Cys Asn Gly Thr Asp Ala Lys Val Lys Leu Ile Lys 
65                  70                  75                  80  


Gln Glu Leu Asp Lys Tyr Lys Ser Ala Val Thr Glu Leu Gln Leu Leu 
                85                  90                  95      


Met Gln Ser Thr Pro Ala Thr Asn Asn Arg Ala Arg Arg Glu Leu Pro 
            100                 105                 110         


Arg Phe Met Asn Tyr Thr Leu Asn Asn Thr Lys Asn Thr Asn Val Thr 
        115                 120                 125             


Leu Ser Lys Lys Arg Lys Arg Arg Phe Leu Gly Phe Leu Leu Gly Val 
    130                 135                 140                 


Gly Ser Ala Ile Ala Ser Gly Ile Ala Val Ser Lys Val Leu His Leu 
145                 150                 155                 160 


Glu Gly Glu Val Asn Lys Ile Lys Ser Ala Leu Leu Ser Thr Asn Lys 
                165                 170                 175     


Ala Val Val Ser Leu Ser Asn Gly Val Ser Val Leu Thr Ser Lys Val 
            180                 185                 190         


Leu Asp Leu Lys Asn Tyr Ile Asp Lys Gln Leu Leu Pro Ile Val Asn 
        195                 200                 205             


Lys Gln Ser Cys Ser Ile Ser Asn Ile Glu Thr Val Ile Glu Phe Gln 
    210                 215                 220                 


Gln Lys Asn Asn Arg Leu Leu Glu Ile Thr Arg Glu Phe Ser Val Asn 
225                 230                 235                 240 


Ala Gly Val Thr Thr Pro Val Ser Thr Tyr Met Leu Thr Asn Ser Glu 
                245                 250                 255     


Leu Leu Ser Leu Ile Asn Asp Met Pro Ile Thr Asn Asp Gln Lys Lys 
            260                 265                 270         


Leu Met Ser Asn Asn Val Gln Ile Val Arg Gln Gln Ser Tyr Ser Ile 
        275                 280                 285             


Met Ser Ile Ile Lys Glu Glu Val Leu Ala Tyr Val Val Gln Leu Pro 
    290                 295                 300                 


Leu Tyr Gly Val Ile Asp Thr Pro Cys Trp Lys Leu His Thr Ser Pro 
305                 310                 315                 320 


Leu Cys Thr Thr Asn Thr Lys Glu Gly Ser Asn Ile Cys Leu Thr Arg 
                325                 330                 335     


Thr Asp Arg Gly Trp Tyr Cys Asp Asn Ala Gly Ser Val Ser Phe Phe 
            340                 345                 350         


Pro Leu Ala Glu Thr Cys Lys Val Gln Ser Asn Arg Val Phe Cys Asp 
        355                 360                 365             


Thr Met Asn Ser Leu Thr Leu Pro Ser Glu Val Asn Leu Cys Asn Ile 
    370                 375                 380                 


Asp Ile Phe Asn Pro Lys Tyr Asp Cys Lys Ile Met Thr Ser Lys Thr 
385                 390                 395                 400 


Asp Val Ser Ser Ser Val Ile Thr Ser Leu Gly Ala Ile Val Ser Cys 
                405                 410                 415     


Tyr Gly Lys Thr Lys Cys Thr Ala Ser Asn Lys Asp Arg Gly Ile Ile 
            420                 425                 430         


Lys Thr Phe Ser Asn Gly Cys Asp Tyr Val Ser Asn Lys Gly Val Asp 
        435                 440                 445             


Thr Val Ser Val Gly Asn Thr Leu Tyr Tyr Val Asn Lys Gln Glu Gly 
    450                 455                 460                 


Lys Ser Leu Tyr Val Lys Gly Glu Pro Ile Ile Asn Phe Tyr Asp Pro 
465                 470                 475                 480 


Leu Val Phe Pro Ser Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Asn 
                485                 490                 495     


Glu Lys Ile Asn Gln Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu 
            500                 505                 510         


Leu His Asn Val Asn Ala Gly Lys Ser Thr Thr Asn Ile Met Ile Thr 
        515                 520                 525             


Thr Ile Ile Ile Val Ile Ile Val Ile Leu Leu Ser Leu Ile Ala Val 
    530                 535                 540                 


Gly Leu Leu Leu Tyr Cys Lys Ala Arg Ser Thr Pro Val Thr Leu Ser 
545                 550                 555                 560 


Lys Asp Gln Leu Ser Gly Ile Asn Asn Ile Ala Phe Ser Asn 
                565                 570                 


<210>  120
<211>  546
<212>  PRT
<213>  Rinderpest virus

<400>  120

Met Arg Ile Pro Leu Ala Ala Leu Ile Ala Met Thr Ile Pro Cys Leu 
1               5                   10                  15      


Ala Thr Gly Gln Ile His Trp Gly Asn Leu Ser Lys Ile Gly Val Val 
            20                  25                  30          


Gly Thr Ser Ser Ala Ser Tyr Lys Val Val Thr Gln Ser Ser His Gln 
        35                  40                  45              


Ser Leu Val Ile Lys Leu Met Pro Asn Ile Thr Ala Ile Asp Asn Cys 
    50                  55                  60                  


Thr Lys Thr Glu Ile Gly Glu Tyr Lys Arg Leu Leu Gly Thr Val Leu 
65                  70                  75                  80  


Lys Pro Ile Gly Glu Ala Leu Asn Ala Ile Thr Lys Asn Ile Lys Pro 
                85                  90                  95      


Ile Gln Ser Ser Thr Thr Ser Arg Arg His Lys Arg Phe Ala Gly Val 
            100                 105                 110         


Val Leu Ala Gly Ala Ala Leu Gly Val Ala Thr Ala Ala Gln Ile Thr 
        115                 120                 125             


Ala Gly Ile Ala Leu His Gln Ser Met Met Asn Ser Gln Ala Ile Glu 
    130                 135                 140                 


Ser Leu Lys Ala Ser Leu Val Thr Thr Asn Gln Ala Ile Glu Glu Ile 
145                 150                 155                 160 


Arg Gln Ala Gly Gln Glu Met Ile Leu Ala Val Gln Gly Val Gln Asp 
                165                 170                 175     


Tyr Ile Asn Asn Glu Leu Val Pro Ala Met Gly Gln Leu Ser Cys Asp 
            180                 185                 190         


Met Val Gly Gln Lys Leu Gly Leu Lys Leu Leu Arg Tyr Tyr Thr Glu 
        195                 200                 205             


Ile Leu Ser Leu Phe Gly Pro Ser Leu Arg Asp Pro Val Ser Ala Glu 
    210                 215                 220                 


Ile Ser Ile Gln Ala Leu Ser Tyr Ala Leu Gly Gly Asp Ile Asn Lys 
225                 230                 235                 240 


Ile Leu Asn Arg Leu Gly Tyr Ser Gly Ser Asp Leu Leu Ala Ile Leu 
                245                 250                 255     


Glu Ser Lys Gly Ile Lys Ala Lys Ile Thr Tyr Val Asp Ile Glu Ser 
            260                 265                 270         


Tyr Phe Ile Val Leu Ser Ile Ala Tyr Pro Ser Leu Ser Glu Ile Lys 
        275                 280                 285             


Gly Val Ile Val His Arg Leu Glu Gly Val Ser Tyr Asn Ile Gly Ser 
    290                 295                 300                 


Gln Glu Trp Tyr Thr Thr Val Pro Arg Tyr Val Ala Thr Gln Gly Tyr 
305                 310                 315                 320 


Leu Ile Ser Asn Phe Asp Asp Thr Pro Cys Ala Phe Thr Pro Glu Gly 
                325                 330                 335     


Thr Ile Ser Ser Gln Asn Ala Leu Tyr Pro Met Ser Pro Leu Leu Gln 
            340                 345                 350         


Glu Cys Phe Arg Gly Ser Thr Arg Ser Cys Ala Arg Thr Leu Val Ser 
        355                 360                 365             


Gly Ser Ile Gly Asn Arg Phe Ile Leu Ser Lys Gly Asn Leu Ile Ala 
    370                 375                 380                 


Asn Cys Ala Ser Ile Leu Cys Lys Cys Tyr Thr Thr Gly Ser Ile Ile 
385                 390                 395                 400 


Ser Gln Asp Pro Asp Lys Ile Leu Thr Tyr Ile Ala Ala Asp Gln Cys 
                405                 410                 415     


Pro Val Val Glu Val Asn Gly Val Thr Ile Gln Val Gly Ser Arg Glu 
            420                 425                 430         


Tyr Pro Asp Ala Val Tyr Leu His Asn Ile Asp Leu Gly Pro Pro Ile 
        435                 440                 445             


Ser Leu Glu Lys Leu Asp Val Gly Thr Asp Leu Gly Asn Ala Val Thr 
    450                 455                 460                 


Lys Leu Glu Arg Ala Lys Asp Leu Leu Asp Ser Ser Asp Leu Ile Leu 
465                 470                 475                 480 


Lys Asn Ile Lys Gly Val Ser Val Thr Asn Thr Gly Tyr Ile Leu Ile 
                485                 490                 495     


Gly Val Gly Leu Ile Ala Val Val Gly Ile Ile Ile Val Thr Cys Cys 
            500                 505                 510         


Cys Lys Lys Ser Ser Ser Asp Ser Arg Ala Ser Thr Val Val Leu Asn 
        515                 520                 525             


Pro Gly Leu Lys Pro Asp Leu Thr Gly Thr Ser Lys Ser Tyr Ile Arg 
    530                 535                 540                 


Ser Leu 
545     


<210>  121
<211>  550
<212>  PRT
<213>  Measles virus

<400>  121

Met Gly Leu Lys Val Asn Val Ser Ala Ile Phe Met Ala Val Leu Leu 
1               5                   10                  15      


Thr Leu Gln Thr Pro Thr Gly Gln Ile His Trp Gly Asn Leu Ser Lys 
            20                  25                  30          


Ile Gly Val Val Gly Ile Gly Ser Ala Ser Tyr Lys Val Met Thr Arg 
        35                  40                  45              


Ser Ser His Gln Ser Leu Val Ile Lys Leu Met Pro Asn Ile Thr Leu 
    50                  55                  60                  


Leu Asn Asn Cys Thr Arg Val Glu Ile Ala Glu Tyr Arg Arg Leu Leu 
65                  70                  75                  80  


Arg Thr Val Leu Glu Pro Ile Arg Asp Ala Leu Asn Ala Met Thr Gln 
                85                  90                  95      


Asn Ile Arg Pro Val Gln Ser Val Ala Ser Ser Arg Arg His Lys Arg 
            100                 105                 110         


Phe Ala Gly Val Val Leu Ala Gly Ala Ala Leu Gly Val Ala Thr Ala 
        115                 120                 125             


Ala Gln Ile Thr Ala Gly Ile Ala Leu His Gln Ser Met Leu Asn Ser 
    130                 135                 140                 


Gln Ala Ile Asp Asn Leu Arg Ala Ser Leu Glu Thr Thr Asn Gln Ala 
145                 150                 155                 160 


Ile Glu Ala Ile Arg Gln Ala Gly Gln Glu Met Ile Leu Ala Val Gln 
                165                 170                 175     


Gly Val Gln Asp Tyr Ile Asn Asn Glu Leu Ile Pro Ser Met Asn Gln 
            180                 185                 190         


Leu Ser Cys Asp Leu Ile Gly Gln Lys Leu Gly Leu Lys Leu Leu Arg 
        195                 200                 205             


Tyr Tyr Thr Glu Ile Leu Ser Leu Phe Gly Pro Ser Leu Arg Asp Pro 
    210                 215                 220                 


Ile Ser Ala Glu Ile Ser Ile Gln Ala Leu Ser Tyr Ala Leu Gly Gly 
225                 230                 235                 240 


Asp Ile Asn Lys Val Leu Glu Lys Leu Gly Tyr Ser Gly Gly Asp Leu 
                245                 250                 255     


Leu Gly Ile Leu Glu Ser Arg Gly Ile Lys Ala Arg Ile Thr His Val 
            260                 265                 270         


Asp Thr Glu Ser Tyr Phe Ile Val Leu Ser Ile Ala Tyr Pro Thr Leu 
        275                 280                 285             


Ser Glu Ile Lys Gly Val Ile Val His Arg Leu Glu Gly Val Ser Tyr 
    290                 295                 300                 


Asn Ile Gly Ser Gln Glu Trp Tyr Thr Thr Val Pro Lys Tyr Val Ala 
305                 310                 315                 320 


Thr Gln Gly Tyr Leu Ile Ser Asn Phe Asp Glu Ser Ser Cys Thr Phe 
                325                 330                 335     


Met Pro Glu Gly Thr Val Cys Ser Gln Asn Ala Leu Tyr Pro Met Ser 
            340                 345                 350         


Pro Leu Leu Gln Glu Cys Leu Arg Gly Ser Thr Lys Ser Cys Ala Arg 
        355                 360                 365             


Thr Leu Val Ser Gly Ser Phe Gly Asn Arg Phe Ile Leu Ser Gln Gly 
    370                 375                 380                 


Asn Leu Ile Ala Asn Cys Ala Ser Ile Leu Cys Lys Cys Tyr Thr Thr 
385                 390                 395                 400 


Gly Thr Ile Ile Asn Gln Asp Pro Asp Lys Ile Leu Thr Tyr Ile Ala 
                405                 410                 415     


Ala Asp His Cys Pro Val Val Glu Val Asn Gly Val Thr Ile Gln Val 
            420                 425                 430         


Gly Ser Arg Arg Tyr Pro Asp Ala Val Tyr Leu His Arg Ile Asp Leu 
        435                 440                 445             


Gly Pro Pro Ile Ser Leu Glu Arg Leu Asp Val Gly Thr Asn Leu Gly 
    450                 455                 460                 


Asn Ala Ile Ala Lys Leu Glu Asp Ala Lys Glu Leu Leu Glu Ser Ser 
465                 470                 475                 480 


Asp Gln Ile Leu Arg Ser Met Lys Gly Leu Ser Ser Thr Ser Ile Val 
                485                 490                 495     


Tyr Ile Leu Ile Ala Val Cys Leu Gly Gly Leu Ile Gly Ile Pro Ala 
            500                 505                 510         


Leu Ile Cys Cys Cys Arg Gly Arg Cys Asn Lys Lys Gly Glu Gln Val 
        515                 520                 525             


Gly Met Ser Arg Pro Gly Leu Lys Pro Asp Leu Thr Gly Thr Ser Lys 
    530                 535                 540                 


Ser Tyr Val Arg Ser Leu 
545                 550 


<210>  122
<211>  551
<212>  PRT
<213>  Human parainfluenza 2 virus

<400>  122

Met His His Leu His Pro Met Ile Val Cys Ile Phe Val Met Tyr Thr 
1               5                   10                  15      


Gly Ile Val Gly Ser Asp Ala Ile Ala Gly Asp Gln Leu Leu Asn Ile 
            20                  25                  30          


Gly Val Ile Gln Ser Lys Ile Arg Ser Leu Met Tyr Tyr Thr Asp Gly 
        35                  40                  45              


Gly Ala Ser Phe Ile Val Val Lys Leu Leu Pro Asn Leu Pro Pro Ser 
    50                  55                  60                  


Asn Gly Thr Cys Asn Ile Thr Ser Leu Asp Ala Tyr Asn Val Thr Leu 
65                  70                  75                  80  


Phe Lys Leu Leu Thr Pro Leu Ile Glu Asn Leu Ser Lys Ile Ser Thr 
                85                  90                  95      


Val Thr Asp Thr Lys Thr Arg Gln Lys Arg Phe Ala Gly Val Val Val 
            100                 105                 110         


Gly Leu Ala Ala Leu Gly Val Ala Thr Ala Ala Gln Ile Thr Ala Ala 
        115                 120                 125             


Val Ala Ile Val Lys Ala Asn Ala Asn Ala Ala Ala Ile Asn Asn Leu 
    130                 135                 140                 


Ala Ser Ser Ile Gln Ser Thr Asn Lys Ala Val Ser Asp Val Ile Asp 
145                 150                 155                 160 


Ala Ser Arg Thr Ile Ala Thr Ala Val Gln Ala Ile Gln Asp His Ile 
                165                 170                 175     


Asn Gly Ala Ile Val Asn Gly Ile Thr Ser Ala Ser Cys Arg Ala His 
            180                 185                 190         


Asp Ala Leu Ile Gly Ser Ile Leu Asn Leu Tyr Leu Thr Glu Leu Thr 
        195                 200                 205             


Thr Ile Phe His Asn Gln Ile Thr Asn Pro Ala Leu Thr Pro Leu Ser 
    210                 215                 220                 


Ile Gln Ala Leu Arg Ile Leu Leu Gly Ser Thr Leu Pro Ile Val Ile 
225                 230                 235                 240 


Glu Ser Lys Leu Asn Thr Asn Leu Asn Thr Ala Glu Leu Leu Ser Ser 
                245                 250                 255     


Gly Leu Leu Thr Gly Gln Ile Ile Ser Ile Ser Pro Met Tyr Met Gln 
            260                 265                 270         


Met Leu Ile Gln Ile Asn Val Pro Thr Phe Ile Met Gln Pro Gly Ala 
        275                 280                 285             


Lys Val Ile Asp Leu Ile Ala Ile Ser Ala Asn His Lys Leu Gln Glu 
    290                 295                 300                 


Val Val Val Gln Val Pro Asn Arg Ile Leu Glu Tyr Ala Asn Glu Leu 
305                 310                 315                 320 


Gln Asn Tyr Pro Ala Asn Asp Cys Val Val Thr Pro Asn Ser Val Phe 
                325                 330                 335     


Cys Arg Tyr Asn Glu Gly Ser Pro Ile Pro Glu Ser Gln Tyr Gln Cys 
            340                 345                 350         


Leu Arg Gly Asn Leu Asn Ser Cys Thr Phe Thr Pro Ile Ile Gly Asn 
        355                 360                 365             


Phe Leu Lys Arg Phe Ala Phe Ala Asn Gly Val Leu Tyr Ala Asn Cys 
    370                 375                 380                 


Lys Ser Leu Leu Cys Arg Cys Ala Asp Pro Pro His Val Val Ser Gln 
385                 390                 395                 400 


Asp Asp Thr Gln Gly Ile Ser Ile Ile Asp Ile Lys Arg Cys Ser Glu 
                405                 410                 415     


Met Met Leu Asp Thr Phe Ser Phe Arg Ile Thr Ser Thr Phe Asn Ala 
            420                 425                 430         


Thr Tyr Val Thr Asp Phe Ser Met Ile Asn Ala Asn Ile Val His Leu 
        435                 440                 445             


Ser Pro Leu Asp Leu Ser Asn Gln Ile Asn Ser Ile Asn Lys Ser Leu 
    450                 455                 460                 


Lys Ser Ala Glu Asp Trp Ile Ala Asp Ser Asn Phe Phe Ala Asn Gln 
465                 470                 475                 480 


Ala Arg Thr Ala Lys Thr Leu Tyr Ser Leu Ser Ala Ile Ala Leu Ile 
                485                 490                 495     


Leu Ser Val Ile Thr Leu Val Val Val Gly Leu Leu Ile Ala Tyr Ile 
            500                 505                 510         


Ile Lys Leu Val Ser Gln Ile His Gln Phe Arg Ser Leu Ala Ala Thr 
        515                 520                 525             


Thr Met Phe His Arg Glu Asn Pro Ala Phe Phe Ser Lys Asn Asn His 
    530                 535                 540                 


Gly Asn Ile Tyr Gly Ile Ser 
545                 550     


<210>  123
<211>  537
<212>  PRT
<213>  Avian metapneumovirus

<400>  123

Met Ser Trp Lys Val Val Leu Leu Leu Val Leu Leu Ala Thr Pro Thr 
1               5                   10                  15      


Gly Gly Leu Glu Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Val Thr 
            20                  25                  30          


Arg Gly Tyr Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe 
        35                  40                  45              


Thr Leu Glu Val Gly Asp Val Glu Asn Leu Thr Cys Thr Asp Gly Pro 
    50                  55                  60                  


Ser Leu Ile Arg Thr Glu Leu Glu Leu Thr Lys Asn Ala Leu Glu Glu 
65                  70                  75                  80  


Leu Lys Thr Val Ser Ala Asp Gln Leu Ala Lys Glu Ala Arg Ile Met 
                85                  90                  95      


Ser Pro Arg Lys Ala Arg Phe Val Leu Gly Ala Ile Ala Leu Gly Val 
            100                 105                 110         


Ala Thr Ala Ala Ala Val Thr Ala Gly Val Ala Ile Ala Lys Thr Ile 
        115                 120                 125             


Arg Leu Glu Gly Glu Val Ala Ala Ile Lys Gly Ala Leu Arg Lys Thr 
    130                 135                 140                 


Asn Glu Ala Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Thr 
145                 150                 155                 160 


Ala Val Asn Asp Leu Lys Asp Phe Ile Ser Lys Lys Leu Thr Pro Ala 
                165                 170                 175     


Ile Asn Lys Asn Lys Cys Asp Ile Ser Asp Leu Lys Met Ala Val Ser 
            180                 185                 190         


Phe Gly Gln Tyr Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser 
        195                 200                 205             


Asp Asn Ala Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp 
    210                 215                 220                 


Ala Glu Leu Val Arg Ala Val Ser Asn Met Pro Thr Ser Ser Gly Gln 
225                 230                 235                 240 


Ile Asn Leu Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe 
                245                 250                 255     


Gly Ile Leu Ile Gly Val Tyr Gly Ser Ser Val Val Tyr Met Val Gln 
            260                 265                 270         


Leu Pro Ile Phe Gly Val Ile Asp Thr Pro Cys Trp Lys Val Lys Ala 
        275                 280                 285             


Ala Pro Leu Cys Ser Gly Lys Asp Gly Ser Tyr Ala Cys Leu Leu Arg 
    290                 295                 300                 


Glu Asp Gln Gly Trp Tyr Cys Gln Asn Ala Gly Ser Thr Val Tyr Tyr 
305                 310                 315                 320 


Pro Asn Glu Glu Asp Cys Glu Val Arg Ser Asp His Val Phe Cys Asp 
                325                 330                 335     


Thr Ala Ala Gly Ile Asn Val Ala Lys Glu Ser Glu Glu Cys Asn Arg 
            340                 345                 350         


Asn Ile Ser Thr Thr Lys Tyr Pro Cys Lys Val Ser Thr Gly Arg His 
        355                 360                 365             


Pro Ile Ser Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys 
    370                 375                 380                 


Tyr Asp Gly Val Ser Cys Ser Ile Gly Ser Asn Lys Val Gly Ile Ile 
385                 390                 395                 400 


Arg Pro Leu Gly Lys Gly Cys Ser Tyr Ile Ser Asn Gln Asp Ala Asp 
                405                 410                 415     


Thr Val Thr Ile Asp Asn Pro Val Tyr Gln Leu Ser Lys Val Glu Gly 
            420                 425                 430         


Glu Gln His Thr Ile Lys Gly Lys Pro Val Ser Ser Asn Phe Asp Pro 
        435                 440                 445             


Ile Glu Phe Pro Glu Asp Gln Phe Asn Ile Ala Leu Asp Gln Val Phe 
    450                 455                 460                 


Glu Ser Val Glu Lys Ser Lys Asn Leu Ile Asp Gln Ser Asn Lys Ile 
465                 470                 475                 480 


Leu Asp Ser Thr Glu Lys Gly Asn Ala Gly Phe Val Met Val Ile Val 
                485                 490                 495     


Leu Ile Val Leu Leu Met Leu Ala Ala Val Gly Val Gly Ile Phe Phe 
            500                 505                 510         


Val Val Lys Lys Arg Lys Ala Ala Pro Lys Phe Pro Met Glu Met Asn 
        515                 520                 525             


Gly Val Asn Asn Lys Gly Phe Ile Pro 
    530                 535         


<210>  124
<211>  537
<212>  PRT
<213>  Phocine distemper virus

<400>  124

Met Val Ile Leu Val His Cys Val Met Gly Gln Ile His Trp Thr Asn 
1               5                   10                  15      


Leu Ser Thr Ile Gly Ile Ile Gly Thr Asp Ser Ser His Tyr Lys Ile 
            20                  25                  30          


Met Thr Arg Ser Ser His Gln Tyr Leu Val Leu Lys Leu Met Pro Asn 
        35                  40                  45              


Val Ser Ile Ile Asp Asn Cys Thr Lys Ala Glu Leu Asp Glu Tyr Glu 
    50                  55                  60                  


Lys Leu Leu Asn Ser Val Leu Glu Pro Ile Asn Gln Ala Leu Thr Leu 
65                  70                  75                  80  


Met Thr Lys Asn Val Lys Ser Leu Gln Ser Leu Gly Ser Gly Arg Arg 
                85                  90                  95      


Gln Arg Arg Phe Ala Gly Val Val Ile Ala Gly Ala Ala Leu Gly Val 
            100                 105                 110         


Ala Thr Ala Ala Gln Ile Thr Ala Gly Val Ala Leu Tyr Gln Ser Asn 
        115                 120                 125             


Leu Asn Ala Gln Ala Ile Gln Ser Leu Arg Ala Ser Leu Glu Gln Ser 
    130                 135                 140                 


Asn Lys Ala Ile Asp Glu Val Arg Gln Ala Ser Gln Asn Ile Ile Ile 
145                 150                 155                 160 


Ala Val Gln Gly Val Gln Asp Tyr Val Asn Asn Glu Ile Val Pro Ala 
                165                 170                 175     


Leu Gln His Met Ser Cys Glu Leu Ile Gly Gln Arg Leu Gly Leu Lys 
            180                 185                 190         


Leu Leu Arg Tyr Tyr Thr Glu Leu Leu Ser Val Phe Gly Pro Ser Leu 
        195                 200                 205             


Arg Asp Pro Ile Ser Ala Glu Ile Ser Ile Gln Ala Leu Ser Tyr Ala 
    210                 215                 220                 


Leu Gly Gly Glu Ile His Lys Ile Leu Glu Lys Leu Gly Tyr Ser Gly 
225                 230                 235                 240 


Asn Asp Met Val Ala Ile Leu Glu Thr Lys Gly Ile Arg Ala Lys Ile 
                245                 250                 255     


Thr His Val Asp Leu Ser Gly Lys Phe Ile Val Leu Ser Ile Ser Tyr 
            260                 265                 270         


Pro Thr Leu Ser Glu Val Lys Gly Val Val Val His Arg Leu Glu Ala 
        275                 280                 285             


Val Ser Tyr Asn Ile Gly Ser Gln Glu Trp Tyr Thr Thr Val Pro Arg 
    290                 295                 300                 


Tyr Val Ala Thr Asn Gly Tyr Leu Ile Ser Asn Phe Asp Glu Ser Ser 
305                 310                 315                 320 


Cys Val Phe Val Ser Glu Ser Ala Ile Cys Ser Gln Asn Ser Leu Tyr 
                325                 330                 335     


Pro Met Ser Pro Ile Leu Gln Gln Cys Leu Arg Gly Glu Thr Ala Ser 
            340                 345                 350         


Cys Ala Arg Thr Leu Val Ser Gly Thr Leu Gly Asn Lys Phe Ile Leu 
        355                 360                 365             


Ser Lys Gly Asn Ile Ile Ala Asn Cys Ala Ser Ile Leu Cys Lys Cys 
    370                 375                 380                 


His Ser Thr Ser Lys Ile Ile Asn Gln Ser Pro Asp Lys Leu Leu Thr 
385                 390                 395                 400 


Phe Ile Ala Ser Asp Thr Cys Ser Leu Val Glu Ile Asp Gly Val Thr 
                405                 410                 415     


Ile Gln Val Gly Ser Arg Gln Tyr Pro Asp Val Val Tyr Ala Ser Lys 
            420                 425                 430         


Val Ile Leu Gly Pro Ala Ile Ser Leu Glu Arg Leu Asp Val Gly Thr 
        435                 440                 445             


Asn Leu Gly Ser Ala Leu Lys Lys Leu Asp Asp Ala Lys Val Leu Ile 
    450                 455                 460                 


Glu Ser Ser Asp Gln Ile Leu Asp Thr Val Lys Asn Ser Tyr Leu Ser 
465                 470                 475                 480 


Leu Gly Thr Leu Ile Ala Leu Pro Val Ser Ile Gly Leu Gly Leu Ile 
                485                 490                 495     


Leu Leu Leu Leu Ile Cys Cys Cys Lys Lys Arg Tyr Gln His Leu Phe 
            500                 505                 510         


Ser Gln Ser Thr Lys Val Ala Pro Val Phe Lys Pro Asp Leu Thr Gly 
        515                 520                 525             


Thr Ser Lys Ser Tyr Val Arg Ser Leu 
    530                 535         


<210>  125
<211>  565
<212>  PRT
<213>  Sendai virus

<400>  125

Met Thr Ala Tyr Ile Gln Arg Ser Gln Cys Ile Ser Thr Ser Leu Leu 
1               5                   10                  15      


Val Val Leu Thr Thr Leu Val Ser Cys Gln Ile Pro Arg Asp Arg Leu 
            20                  25                  30          


Ser Asn Ile Gly Val Ile Val Asp Glu Gly Lys Ser Leu Lys Ile Ala 
        35                  40                  45              


Gly Ser His Glu Ser Arg Tyr Ile Val Leu Ser Leu Val Pro Gly Val 
    50                  55                  60                  


Asp Leu Glu Asn Gly Cys Gly Thr Ala Gln Val Ile Gln Tyr Lys Ser 
65                  70                  75                  80  


Leu Leu Asn Arg Leu Leu Ile Pro Leu Arg Asp Ala Leu Asp Leu Gln 
                85                  90                  95      


Glu Ala Leu Ile Thr Val Thr Asn Asp Thr Thr Gln Asn Ala Gly Val 
            100                 105                 110         


Pro Gln Ser Arg Phe Phe Gly Ala Val Ile Gly Thr Ile Ala Leu Gly 
        115                 120                 125             


Val Ala Thr Ser Ala Gln Ile Thr Ala Gly Ile Ala Leu Ala Glu Ala 
    130                 135                 140                 


Arg Glu Ala Lys Arg Asp Ile Ala Leu Ile Lys Glu Ser Met Thr Lys 
145                 150                 155                 160 


Thr His Lys Ser Val Glu Leu Leu Gln Asn Ala Val Gly Glu Gln Ile 
                165                 170                 175     


Leu Ala Leu Lys Thr Leu Gln Asp Phe Val Asn Asp Glu Ile Lys Pro 
            180                 185                 190         


Ala Ile Ser Glu Leu Gly Cys Glu Thr Ala Ala Leu Arg Leu Gly Ile 
        195                 200                 205             


Lys Leu Thr Gln His Tyr Phe Gly Leu Leu Thr Ala Phe Gly Ser Asn 
    210                 215                 220                 


Phe Gly Thr Ile Gly Glu Lys Ser Arg Thr Leu Gln Ala Leu Ser Ser 
225                 230                 235                 240 


Leu Tyr Ser Ala Asn Ile Thr Glu Ile Met Thr Thr Ile Arg Thr Gly 
                245                 250                 255     


Gln Ser Asn Ile Tyr Asp Val Ile Tyr Thr Glu Gln Ile Lys Gly Thr 
            260                 265                 270         


Val Ile Asp Val Asp Leu Glu Arg Tyr Met Val Thr Leu Ser Val Lys 
        275                 280                 285             


Ile Pro Ile Leu Ser Glu Val Pro Gly Val Leu Ile His Lys Ala Ser 
    290                 295                 300                 


Ser Ile Ser Tyr Asn Ile Asp Gly Glu Glu Trp Tyr Val Thr Val Pro 
305                 310                 315                 320 


Ser His Ile Leu Ser Arg Ala Ser Phe Leu Gly Gly Ala Asp Ile Thr 
                325                 330                 335     


Asp Cys Val Glu Ser Arg Leu Thr Tyr Ile Cys Pro Arg Asp Pro Ala 
            340                 345                 350         


Gln Leu Ile Pro Asp Ser Gln Gln Lys Cys Ile Leu Gly Asp Thr Thr 
        355                 360                 365             


Arg Cys Pro Val Thr Lys Val Val Asp Ser Leu Ile Pro Lys Phe Ala 
    370                 375                 380                 


Phe Val Asn Gly Gly Val Val Ala Asn Arg Ile Ala Ser Thr Cys Thr 
385                 390                 395                 400 


Cys Gly Thr Gly Arg Arg Pro Ile Ser Gln Asp Arg Ser Lys Gly Val 
                405                 410                 415     


Ala Phe Leu Thr His Asp Asn Cys Gly Leu Ile Gly Val Asn Gly Val 
            420                 425                 430         


Glu Leu Tyr Ala Asn Arg Arg Gly His Asp Ala Thr Trp Gly Val Gln 
        435                 440                 445             


Asn Leu Thr Val Gly Pro Ala Ile Ala Ile Arg Pro Val Asp Ile Ser 
    450                 455                 460                 


Leu Asn Leu Ala Asp Ala Thr Asn Phe Leu Gln Asp Ser Lys Ala Glu 
465                 470                 475                 480 


Leu Glu Lys Ala Arg Lys Ile Leu Ser Glu Val Gly Arg Trp Tyr Asn 
                485                 490                 495     


Ser Arg Glu Thr Val Ile Thr Ile Ile Val Val Met Val Val Ile Leu 
            500                 505                 510         


Val Val Ile Ile Val Ile Val Ile Val Leu Tyr Arg Leu Lys Arg Ser 
        515                 520                 525             


Met Leu Met Gly Asn Pro Asp Glu Arg Ile Pro Arg Asp Thr Tyr Thr 
    530                 535                 540                 


Leu Glu Pro Lys Ile Arg His Met Tyr Thr Asn Gly Gly Phe Asp Ala 
545                 550                 555                 560 


Met Ala Glu Lys Arg 
                565 


<210>  126
<211>  540
<212>  PRT
<213>  Bovine parainfluenza 3 virus

<400>  126

Met Ile Ile Thr Asn Thr Ile Ile Ile Ile Leu Ile Ile Ser Pro Ser 
1               5                   10                  15      


Phe Cys Gln Ile Asp Ile Thr Lys Leu Gln Arg Val Gly Val Leu Val 
            20                  25                  30          


Asn Asn Pro Lys Gly Met Lys Ile Ser Gln Asn Phe Glu Thr Arg Tyr 
        35                  40                  45              


Leu Ile Leu Ser Leu Ile Pro Lys Ile Glu Asn Ser His Ser Cys Gly 
    50                  55                  60                  


Asp Gln Gln Ile Asn Gln Tyr Lys Lys Leu Leu Asp Arg Leu Ile Ile 
65                  70                  75                  80  


Pro Leu Tyr Asp Gly Leu Lys Leu Gln Lys Asp Val Ile Val Val Ser 
                85                  90                  95      


His Glu Thr Asn Asn Asn Thr Asn Ser Arg Thr Lys Arg Phe Phe Gly 
            100                 105                 110         


Glu Ile Ile Gly Thr Ile Ala Ile Gly Ile Ala Thr Ser Ala Gln Ile 
        115                 120                 125             


Thr Ala Ala Val Ala Leu Val Glu Ala Lys Gln Ala Lys Ser Asp Ile 
    130                 135                 140                 


Glu Lys Leu Lys Glu Ala Ile Arg Asp Thr Asn Lys Ala Val Gln Ser 
145                 150                 155                 160 


Ile Gln Ser Ser Val Gly Asn Leu Ile Val Ala Val Lys Ser Val Gln 
                165                 170                 175     


Asp Tyr Val Asn Asn Glu Ile Val Pro Ser Ile Thr Arg Leu Gly Cys 
            180                 185                 190         


Glu Ala Ala Gly Leu Lys Leu Gly Ile Ala Leu Thr Gln His Tyr Ser 
        195                 200                 205             


Glu Leu Thr Asn Ile Phe Gly Asp Asn Ile Gly Thr Leu Lys Glu Lys 
    210                 215                 220                 


Gly Ile Lys Leu Gln Gly Ile Ala Ser Leu Tyr His Thr Asn Ile Thr 
225                 230                 235                 240 


Glu Ile Phe Thr Thr Ser Thr Val Asp Gln Tyr Asp Ile Tyr Asp Leu 
                245                 250                 255     


Leu Phe Thr Glu Ser Ile Lys Met Arg Val Ile Asp Val Asp Leu Ser 
            260                 265                 270         


Asp Tyr Ser Ile Thr Leu Gln Val Arg Leu Pro Leu Leu Thr Lys Ile 
        275                 280                 285             


Ser Asn Thr Gln Ile Tyr Lys Val Asp Ser Ile Ser Tyr Asn Ile Gln 
    290                 295                 300                 


Gly Lys Glu Trp Tyr Ile Pro Leu Pro Asn His Ile Met Thr Lys Gly 
305                 310                 315                 320 


Ala Phe Leu Gly Gly Ala Asp Ile Lys Glu Cys Ile Glu Ala Phe Ser 
                325                 330                 335     


Ser Tyr Ile Cys Pro Ser Asp Pro Gly Phe Thr Leu Asn His Glu Ile 
            340                 345                 350         


Glu Asn Cys Leu Ser Gly Asn Ile Thr Gln Cys Pro Lys Thr Ile Val 
        355                 360                 365             


Thr Ser Asp Val Val Pro Arg Tyr Ala Phe Val Asn Gly Gly Leu Ile 
    370                 375                 380                 


Ala Asn Cys Ile Thr Thr Thr Cys Thr Cys Asn Gly Val Asp Asn Arg 
385                 390                 395                 400 


Ile Asn Gln Ser Pro Asp Gln Gly Ile Lys Ile Ile Thr His Lys Glu 
                405                 410                 415     


Cys Gln Val Ile Gly Ile Asn Gly Met Leu Phe Ser Thr Asn Arg Glu 
            420                 425                 430         


Gly Thr Leu Ala Thr Tyr Thr Phe Asp Asp Ile Ile Leu Asn Asn Ser 
        435                 440                 445             


Val Ala Leu Asn Pro Ile Asp Ile Ser Met Glu Leu Asn Lys Ala Lys 
    450                 455                 460                 


Leu Glu Leu Glu Glu Ser Lys Glu Trp Ile Lys Lys Ser Asn Gln Lys 
465                 470                 475                 480 


Leu Asp Ser Val Gly Ser Trp Tyr Gln Ser Ser Ala Thr Ile Thr Ile 
                485                 490                 495     


Ile Ile Val Met Ile Val Val Leu Phe Ile Ile Asn Ile Thr Ile Ile 
            500                 505                 510         


Val Val Ile Ile Arg His His Arg Ile Gln Gly Lys Asn Gln Asn Asp 
        515                 520                 525             


Lys Asn Ser Glu Pro Tyr Val Leu Thr Ser Arg Gln 
    530                 535                 540 


<210>  127
<211>  550
<212>  PRT
<213>  Measles virus

<400>  127

Met Gly Leu Lys Val Asn Val Ser Ala Ile Phe Met Ala Val Leu Leu 
1               5                   10                  15      


Thr Leu Gln Thr Pro Thr Gly Gln Ile His Trp Gly Asn Leu Ser Lys 
            20                  25                  30          


Ile Gly Val Val Gly Ile Gly Ser Ala Ser Tyr Lys Val Met Thr Arg 
        35                  40                  45              


Ser Ser His Gln Ser Leu Val Ile Lys Leu Met Pro Asn Ile Thr Leu 
    50                  55                  60                  


Leu Asn Asn Cys Thr Arg Val Glu Ile Ala Glu Tyr Arg Arg Leu Leu 
65                  70                  75                  80  


Arg Thr Val Leu Glu Pro Ile Arg Asp Ala Leu Asn Ala Met Thr Gln 
                85                  90                  95      


Asn Ile Arg Pro Val Gln Ser Val Ala Ser Ser Arg Arg His Lys Arg 
            100                 105                 110         


Phe Ala Gly Val Val Leu Ala Gly Ala Ala Leu Gly Val Ala Thr Ala 
        115                 120                 125             


Ala Gln Ile Thr Ala Gly Ile Ala Leu His Gln Ser Met Leu Asn Ser 
    130                 135                 140                 


Gln Ala Ile Asp Asn Leu Arg Ala Ser Leu Glu Thr Thr Asn Gln Ala 
145                 150                 155                 160 


Ile Glu Ala Ile Arg Gln Ala Gly Gln Glu Met Ile Leu Ala Val Gln 
                165                 170                 175     


Gly Val Gln Asp Tyr Ile Asn Asn Glu Leu Ile Pro Ser Met Asn Gln 
            180                 185                 190         


Leu Ser Cys Asp Leu Ile Gly Gln Lys Leu Gly Leu Lys Leu Leu Arg 
        195                 200                 205             


Tyr Tyr Thr Glu Ile Leu Ser Leu Phe Gly Pro Ser Leu Arg Asp Pro 
    210                 215                 220                 


Ile Ser Ala Glu Ile Ser Ile Gln Ala Leu Ser Tyr Ala Leu Gly Gly 
225                 230                 235                 240 


Asp Ile Asn Lys Val Leu Glu Lys Leu Gly Tyr Ser Gly Gly Asp Leu 
                245                 250                 255     


Leu Gly Ile Leu Glu Ser Arg Gly Ile Lys Ala Arg Ile Thr His Val 
            260                 265                 270         


Asp Thr Glu Ser Tyr Phe Ile Val Leu Ser Ile Ala Tyr Pro Thr Leu 
        275                 280                 285             


Ser Glu Ile Lys Gly Val Ile Val His Arg Leu Glu Gly Val Ser Tyr 
    290                 295                 300                 


Asn Ile Gly Ser Gln Glu Trp Tyr Thr Thr Val Pro Lys Tyr Val Ala 
305                 310                 315                 320 


Thr Gln Gly Tyr Leu Ile Ser Asn Phe Asp Glu Ser Ser Cys Thr Phe 
                325                 330                 335     


Met Pro Glu Gly Thr Val Cys Ser Gln Asn Ala Leu Tyr Pro Met Ser 
            340                 345                 350         


Pro Leu Leu Gln Glu Cys Leu Arg Gly Ser Thr Lys Ser Cys Ala Arg 
        355                 360                 365             


Thr Leu Val Ser Gly Ser Phe Gly Asn Arg Phe Ile Leu Ser Gln Gly 
    370                 375                 380                 


Asn Leu Ile Ala Asn Cys Ala Ser Ile Leu Cys Lys Cys Tyr Thr Thr 
385                 390                 395                 400 


Gly Thr Ile Ile Asn Gln Asp Pro Asp Lys Ile Leu Thr Tyr Ile Ala 
                405                 410                 415     


Ala Asp His Cys Pro Val Val Glu Val Asn Gly Val Thr Ile Gln Val 
            420                 425                 430         


Gly Ser Arg Arg Tyr Pro Asp Ala Val Tyr Leu His Arg Ile Asp Leu 
        435                 440                 445             


Gly Pro Pro Ile Ser Leu Glu Arg Leu Asp Val Gly Thr Asn Leu Gly 
    450                 455                 460                 


Asn Ala Ile Ala Lys Leu Glu Asp Ala Lys Glu Leu Leu Glu Ser Ser 
465                 470                 475                 480 


Asp Gln Ile Leu Arg Ser Met Lys Gly Leu Ser Ser Thr Ser Ile Val 
                485                 490                 495     


Tyr Ile Leu Ile Ala Val Cys Leu Gly Gly Leu Ile Gly Ile Pro Ala 
            500                 505                 510         


Leu Ile Cys Cys Cys Arg Gly Arg Cys Asn Lys Lys Gly Glu Gln Val 
        515                 520                 525             


Gly Met Ser Arg Pro Gly Leu Lys Pro Asp Leu Thr Gly Thr Ser Lys 
    530                 535                 540                 


Ser Tyr Val Arg Ser Leu 
545                 550 


<210>  128
<211>  553
<212>  PRT
<213>  Human parainfluenza 2 virus

<400>  128

Met Gly Ser Arg Pro Ser Thr Lys Ile Pro Ala Pro Met Met Leu Thr 
1               5                   10                  15      


Ile Arg Val Ala Leu Val Leu Ser Cys Ile Cys Pro Ala Asn Ser Ile 
            20                  25                  30          


Asp Gly Arg Pro Leu Ala Ala Ala Gly Ile Val Val Thr Gly Asp Lys 
        35                  40                  45              


Ala Val Asn Ile Tyr Thr Ser Ser Gln Thr Gly Ser Ile Ile Val Lys 
    50                  55                  60                  


Leu Leu Pro Asn Leu Pro Lys Asp Lys Glu Ala Cys Ala Lys Ala Pro 
65                  70                  75                  80  


Leu Asp Ala Tyr Asn Arg Thr Leu Thr Thr Leu Leu Thr Pro Leu Gly 
                85                  90                  95      


Asp Ser Ile Arg Arg Ile Gln Glu Ser Val Thr Thr Ser Gly Gly Gly 
            100                 105                 110         


Arg Gln Gly Arg Leu Ile Gly Ala Ile Ile Gly Gly Val Ala Leu Gly 
        115                 120                 125             


Val Ala Thr Ala Ala Gln Ile Thr Ala Ala Ala Ala Leu Ile Gln Ala 
    130                 135                 140                 


Lys Gln Asn Ala Ala Asn Ile Leu Arg Leu Lys Glu Ser Ile Ala Ala 
145                 150                 155                 160 


Thr Asn Glu Ala Val His Glu Val Thr Asp Gly Leu Ser Gln Leu Ala 
                165                 170                 175     


Val Ala Val Gly Lys Met Gln Gln Phe Val Asn Asp Gln Phe Asn Lys 
            180                 185                 190         


Thr Ala Gln Glu Leu Asp Cys Ile Lys Ile Ala Gln Gln Val Gly Val 
        195                 200                 205             


Glu Leu Asn Leu Tyr Leu Thr Glu Leu Thr Thr Val Phe Gly Pro Gln 
    210                 215                 220                 


Ile Thr Ser Pro Ala Leu Asn Lys Leu Thr Ile Gln Ala Leu Tyr Asn 
225                 230                 235                 240 


Leu Ala Gly Gly Asn Met Asp Tyr Leu Leu Thr Lys Leu Gly Ile Gly 
                245                 250                 255     


Asn Asn Gln Leu Ser Ser Leu Ile Gly Ser Gly Leu Ile Thr Gly Asn 
            260                 265                 270         


Pro Ile Leu Tyr Asp Ser Gln Thr Gln Leu Leu Gly Ile Gln Val Thr 
        275                 280                 285             


Leu Pro Ser Val Gly Asn Leu Asn Asn Met Arg Ala Thr Tyr Leu Glu 
    290                 295                 300                 


Thr Leu Ser Val Ser Thr Thr Arg Gly Phe Ala Ser Ala Leu Val Pro 
305                 310                 315                 320 


Lys Val Val Thr Gln Val Gly Ser Val Ile Glu Glu Leu Asp Thr Ser 
                325                 330                 335     


Tyr Cys Ile Glu Thr Asp Leu Asp Leu Tyr Cys Thr Arg Ile Val Thr 
            340                 345                 350         


Phe Pro Met Ser Pro Gly Ile Tyr Ser Cys Leu Ser Gly Asn Thr Ser 
        355                 360                 365             


Ala Cys Met Tyr Ser Lys Thr Glu Gly Ala Leu Thr Thr Pro Tyr Met 
    370                 375                 380                 


Thr Ile Lys Gly Ser Val Ile Ala Asn Cys Lys Met Thr Thr Cys Arg 
385                 390                 395                 400 


Cys Val Asn Pro Pro Gly Ile Ile Ser Gln Asn Tyr Gly Glu Ala Val 
                405                 410                 415     


Ser Leu Ile Asp Lys Gln Ser Cys Asn Val Leu Ser Leu Gly Gly Ile 
            420                 425                 430         


Thr Leu Arg Leu Ser Gly Glu Phe Asp Val Thr Tyr Gln Lys Asn Ile 
        435                 440                 445             


Ser Ile Gln Asp Ser Gln Val Ile Ile Thr Gly Asn Leu Asp Ile Ser 
    450                 455                 460                 


Thr Glu Leu Gly Asn Val Asn Asn Ser Ile Ser Asn Ala Leu Asn Lys 
465                 470                 475                 480 


Leu Glu Glu Ser Asn Arg Lys Leu Asp Lys Val Asn Val Lys Leu Thr 
                485                 490                 495     


Ser Thr Ser Ala Leu Ile Thr Tyr Ile Val Leu Thr Ile Ile Ser Leu 
            500                 505                 510         


Val Phe Gly Ile Leu Ser Leu Ile Leu Ala Cys Tyr Leu Met Tyr Lys 
        515                 520                 525             


Gln Lys Ala Gln Gln Lys Thr Leu Leu Trp Leu Gly Asn Asn Thr Leu 
    530                 535                 540                 


Asp Gln Met Arg Ala Thr Thr Lys Met 
545                 550             


<210>  129
<211>  553
<212>  PRT
<213>  Newcastle disease virus

<400>  129

Met Gly Ser Arg Pro Ser Thr Lys Ile Pro Ala Pro Met Met Leu Thr 
1               5                   10                  15      


Ile Arg Val Ala Leu Val Leu Ser Cys Ile Cys Pro Ala Asn Ser Ile 
            20                  25                  30          


Asp Gly Arg Pro Leu Ala Ala Ala Gly Ile Val Val Thr Gly Asp Lys 
        35                  40                  45              


Ala Val Asn Ile Tyr Thr Ser Ser Gln Thr Gly Ser Ile Ile Val Lys 
    50                  55                  60                  


Leu Leu Pro Asn Leu Pro Lys Asp Lys Glu Ala Cys Ala Lys Ala Pro 
65                  70                  75                  80  


Leu Asp Ala Tyr Asn Arg Thr Leu Thr Thr Leu Leu Thr Pro Leu Gly 
                85                  90                  95      


Asp Ser Ile Arg Arg Ile Gln Glu Ser Val Thr Thr Ser Gly Gly Gly 
            100                 105                 110         


Arg Gln Gly Arg Leu Ile Gly Ala Ile Ile Gly Gly Val Ala Leu Gly 
        115                 120                 125             


Val Ala Thr Ala Ala Gln Ile Thr Ala Ala Ala Ala Leu Ile Gln Ala 
    130                 135                 140                 


Lys Gln Asn Ala Ala Asn Ile Leu Arg Leu Lys Glu Ser Ile Ala Ala 
145                 150                 155                 160 


Thr Asn Glu Ala Val His Glu Val Thr Asp Gly Leu Ser Gln Leu Ala 
                165                 170                 175     


Val Ala Val Gly Lys Met Gln Gln Phe Val Asn Asp Gln Phe Asn Lys 
            180                 185                 190         


Thr Ala Gln Glu Leu Asp Cys Ile Lys Ile Ala Gln Gln Val Gly Val 
        195                 200                 205             


Glu Leu Asn Leu Tyr Leu Thr Glu Leu Thr Thr Val Phe Gly Pro Gln 
    210                 215                 220                 


Ile Thr Ser Pro Ala Leu Asn Lys Leu Thr Ile Gln Ala Leu Tyr Asn 
225                 230                 235                 240 


Leu Ala Gly Gly Asn Met Asp Tyr Leu Leu Thr Lys Leu Gly Ile Gly 
                245                 250                 255     


Asn Asn Gln Leu Ser Ser Leu Ile Gly Ser Gly Leu Ile Thr Gly Asn 
            260                 265                 270         


Pro Ile Leu Tyr Asp Ser Gln Thr Gln Leu Leu Gly Ile Gln Val Thr 
        275                 280                 285             


Leu Pro Ser Val Gly Asn Leu Asn Asn Met Arg Ala Thr Tyr Leu Glu 
    290                 295                 300                 


Thr Leu Ser Val Ser Thr Thr Arg Gly Phe Ala Ser Ala Leu Val Pro 
305                 310                 315                 320 


Lys Val Val Thr Gln Val Gly Ser Val Ile Glu Glu Leu Asp Thr Ser 
                325                 330                 335     


Tyr Cys Ile Glu Thr Asp Leu Asp Leu Tyr Cys Thr Arg Ile Val Thr 
            340                 345                 350         


Phe Pro Met Ser Pro Gly Ile Tyr Ser Cys Leu Ser Gly Asn Thr Ser 
        355                 360                 365             


Ala Cys Met Tyr Ser Lys Thr Glu Gly Ala Leu Thr Thr Pro Tyr Met 
    370                 375                 380                 


Thr Ile Lys Gly Ser Val Ile Ala Asn Cys Lys Met Thr Thr Cys Arg 
385                 390                 395                 400 


Cys Val Asn Pro Pro Gly Ile Ile Ser Gln Asn Tyr Gly Glu Ala Val 
                405                 410                 415     


Ser Leu Ile Asp Lys Gln Ser Cys Asn Val Leu Ser Leu Gly Gly Ile 
            420                 425                 430         


Thr Leu Arg Leu Ser Gly Glu Phe Asp Val Thr Tyr Gln Lys Asn Ile 
        435                 440                 445             


Ser Ile Gln Asp Ser Gln Val Ile Ile Thr Gly Asn Leu Asp Ile Ser 
    450                 455                 460                 


Thr Glu Leu Gly Asn Val Asn Asn Ser Ile Ser Asn Ala Leu Asn Lys 
465                 470                 475                 480 


Leu Glu Glu Ser Asn Arg Lys Leu Asp Lys Val Asn Val Lys Leu Thr 
                485                 490                 495     


Ser Thr Ser Ala Leu Ile Thr Tyr Ile Val Leu Thr Ile Ile Ser Leu 
            500                 505                 510         


Val Phe Gly Ile Leu Ser Leu Ile Leu Ala Cys Tyr Leu Met Tyr Lys 
        515                 520                 525             


Gln Lys Ala Gln Gln Lys Thr Leu Leu Trp Leu Gly Asn Asn Thr Leu 
    530                 535                 540                 


Asp Gln Met Arg Ala Thr Thr Lys Met 
545                 550             


<210>  130
<211>  534
<212>  PRT
<213>  Measles virus

<400>  130

Met Gly Leu Arg Val Asn Val Ser Ala Ile Phe Met Ala Val Leu Leu 
1               5                   10                  15      


Thr Leu Gln Thr Pro Thr Gly Gln Ile His Trp Gly Asn Leu Ser Lys 
            20                  25                  30          


Ile Gly Val Val Gly Ile Gly Ser Ala Ser Tyr Lys Val Met Thr Arg 
        35                  40                  45              


Ser Ser His Gln Ser Leu Val Ile Lys Leu Met Pro Asn Thr Thr Leu 
    50                  55                  60                  


Leu Asn Asn Cys Thr Arg Val Glu Ile Ala Glu Tyr Arg Arg Leu Leu 
65                  70                  75                  80  


Arg Thr Val Leu Glu Pro Ile Arg Asp Ala Leu Asn Ala Met Thr Gln 
                85                  90                  95      


Asn Ile Arg Pro Val Gln Ile Val Ala Ser Ser Arg Arg His Lys Arg 
            100                 105                 110         


Phe Ala Gly Val Val Leu Ala Gly Ala Ala Leu Gly Val Ala Thr Ala 
        115                 120                 125             


Ala Gln Ile Thr Ala Gly Ile Ala Leu His Gln Ser Met Leu Asn Ser 
    130                 135                 140                 


Gln Ala Ile Asp Asn Leu Arg Ala Ser Leu Glu Thr Thr Asn Gln Ala 
145                 150                 155                 160 


Ile Glu Ala Ile Arg Gln Thr Gly Gln Glu Met Ile Leu Ala Val Gln 
                165                 170                 175     


Gly Val Gln Asp Tyr Ile Asn Asn Glu Leu Ile Pro Ser Met Asn Gln 
            180                 185                 190         


Leu Ser Cys Asp Leu Ile Gly Gln Lys Leu Gly Leu Lys Leu Leu Arg 
        195                 200                 205             


Tyr Tyr Thr Glu Ile Leu Ser Leu Phe Gly Pro Ser Leu Arg Asp Pro 
    210                 215                 220                 


Ile Ser Ala Glu Ile Ser Ile Gln Ala Leu Ser Tyr Val Leu Gly Gly 
225                 230                 235                 240 


Asp Ile Asn Lys Val Leu Glu Lys Leu Gly Tyr Ser Gly Gly Asp Leu 
                245                 250                 255     


Leu Gly Ile Leu Glu Ser Arg Gly Ile Lys Ala Arg Ile Thr His Val 
            260                 265                 270         


Asp Thr Glu Ser Tyr Phe Ile Val Leu Ser Ile Ala Tyr Pro Thr Leu 
        275                 280                 285             


Ser Glu Ile Lys Gly Val Ile Val His Arg Leu Glu Gly Val Ser Tyr 
    290                 295                 300                 


Asn Ile Gly Ser Gln Glu Trp Tyr Thr Thr Val Pro Lys Tyr Val Ala 
305                 310                 315                 320 


Thr Gln Gly Tyr Leu Ile Ser Asn Phe Asp Glu Ser Ser Cys Thr Phe 
                325                 330                 335     


Met Pro Glu Gly Thr Val Cys Ser Gln Asn Ala Leu Tyr Pro Met Ser 
            340                 345                 350         


Pro Leu Leu Gln Glu Cys Leu Arg Gly Ser Thr Lys Ser Cys Ala Arg 
        355                 360                 365             


Thr Leu Val Ser Gly Ser Phe Gly Asn Arg Phe Ile Leu Ser Gln Gly 
    370                 375                 380                 


Asn Leu Ile Ala Asn Cys Ala Ser Ile Leu Cys Lys Cys Tyr Thr Thr 
385                 390                 395                 400 


Gly Thr Ile Ile Asn Gln Asp Pro Asp Lys Ile Leu Thr His Ile Ala 
                405                 410                 415     


Ala Asp His Cys Pro Val Val Glu Val Asn Gly Val Thr Ile Gln Val 
            420                 425                 430         


Gly Ser Arg Arg Tyr Pro Asp Ala Val Tyr Leu His Arg Ile Asp Leu 
        435                 440                 445             


Gly Pro Pro Ile Ser Leu Glu Arg Leu Asp Val Gly Thr Ser Leu Gly 
    450                 455                 460                 


Ser Ala Ile Ala Lys Leu Glu Asp Ala Lys Glu Leu Leu Glu Ser Ser 
465                 470                 475                 480 


Asp Gln Ile Leu Arg Ser Met Lys Gly Leu Ser Ser Thr Ser Ile Val 
                485                 490                 495     


Tyr Ile Leu Ile Ala Val Cys Leu Gly Gly Leu Ile Gly Ile Pro Ala 
            500                 505                 510         


Leu Ile Cys Cys Cys Arg Gly Arg Cys Asn Lys Arg Glu Asn Lys Leu 
        515                 520                 525             


Val Cys Gln Asp Gln Ala 
    530                 


<210>  131
<211>  529
<212>  PRT
<213>  Measles virus

<400>  131

Met Ser Ile Met Gly Leu Lys Val Asn Val Ser Ala Ile Phe Met Ala 
1               5                   10                  15      


Val Leu Leu Thr Leu Gln Thr Pro Thr Gly Gln Ile His Trp Gly Asn 
            20                  25                  30          


Leu Ser Lys Ile Gly Val Val Gly Ile Gly Ser Ala Ser Tyr Lys Val 
        35                  40                  45              


Met Thr Arg Ser Ser His Gln Ser Leu Val Ile Lys Leu Met Pro Asn 
    50                  55                  60                  


Ile Thr Leu Leu Asn Asn Cys Thr Arg Val Glu Ile Ala Glu Tyr Arg 
65                  70                  75                  80  


Arg Leu Leu Arg Thr Val Leu Glu Pro Ile Arg Asp Ala Leu Asn Ala 
                85                  90                  95      


Met Thr Gln Asn Ile Arg Leu Val Gln Ser Val Ala Ser Ser Arg Arg 
            100                 105                 110         


His Lys Arg Phe Ala Gly Val Val Leu Ala Gly Ala Ala Leu Gly Val 
        115                 120                 125             


Ala Thr Ala Ala Gln Ile Thr Ala Gly Ile Ala Leu His Gln Ser Met 
    130                 135                 140                 


Leu Ser Ser Gln Ala Ile Asp Asn Leu Arg Ala Ser Leu Glu Thr Thr 
145                 150                 155                 160 


Asn Gln Ala Ile Glu Ala Ile Arg Gln Ala Gly Gln Glu Met Ile Leu 
                165                 170                 175     


Ala Val Gln Gly Val Gln Asp Tyr Ile Asn Asn Glu Leu Ile Pro Ser 
            180                 185                 190         


Met Asn Gln Leu Ser Cys Asp Leu Ile Gly Gln Lys Leu Gly Leu Lys 
        195                 200                 205             


Leu Leu Arg Tyr Tyr Thr Glu Ile Leu Ser Leu Phe Gly Pro Ser Leu 
    210                 215                 220                 


Arg Asp Pro Ile Ser Ala Glu Ile Ser Ile Gln Ala Leu Ser Tyr Ala 
225                 230                 235                 240 


Leu Gly Gly Asp Ile Asn Lys Val Leu Glu Lys Leu Gly Tyr Ser Gly 
                245                 250                 255     


Gly Asp Leu Leu Gly Ile Leu Glu Ser Arg Gly Ile Lys Ala Arg Ile 
            260                 265                 270         


Thr His Val Asp Thr Glu Ser Tyr Phe Ile Val Leu Ser Ile Ala Tyr 
        275                 280                 285             


Pro Thr Leu Ser Glu Ile Lys Glu Val Ile Val His Arg Leu Glu Gly 
    290                 295                 300                 


Val Ser Tyr Asn Ile Gly Ser Gln Glu Trp Tyr Thr Thr Val Pro Lys 
305                 310                 315                 320 


Tyr Val Ala Thr Gln Gly Tyr Leu Ile Ser Asn Phe Asp Glu Ser Ser 
                325                 330                 335     


Cys Thr Phe Met Pro Glu Gly Thr Val Cys Ser Gln Asn Ala Leu Tyr 
            340                 345                 350         


Pro Met Ser Pro Leu Leu Gln Glu Cys Leu Arg Gly Ser Thr Lys Ser 
        355                 360                 365             


Cys Ala Arg Thr Leu Val Ser Gly Ser Phe Gly Asn Arg Phe Ile Leu 
    370                 375                 380                 


Ser Gln Gly Asn Leu Ile Ala Asn Cys Ala Ser Ile Leu Cys Lys Cys 
385                 390                 395                 400 


Tyr Thr Thr Gly Thr Ile Ile Arg Gln Asp Pro Asp Lys Ile Leu Thr 
                405                 410                 415     


Tyr Ile Ala Ala Asp His Cys Pro Val Val Glu Val Asn Gly Val Thr 
            420                 425                 430         


Ile Gln Val Gly Ser Arg Arg Tyr Pro Asp Ala Val Asp Leu His Arg 
        435                 440                 445             


Ile Asp Leu Gly Pro Pro Ile Ser Leu Glu Arg Leu Asp Val Gly Thr 
    450                 455                 460                 


Asn Leu Gly Ser Ala Ile Ala Lys Leu Glu Asp Ala Lys Glu Leu Leu 
465                 470                 475                 480 


Glu Ser Ser Asp Gln Ile Leu Arg Ser Met Lys Gly Leu Ser Ser Thr 
                485                 490                 495     


Ser Ile Val Tyr Ile Leu Ile Ala Val Cys Leu Gly Gly Leu Ile Gly 
            500                 505                 510         


Ile Pro Ala Leu Ile Cys Cys Cys Arg Gly Arg Cys Asn Lys Lys Gly 
        515                 520                 525             


Glu 
    


<210>  132
<211>  550
<212>  PRT
<213>  Measles virus

<400>  132

Met Gly Leu Lys Val Asn Val Ser Ala Ile Phe Met Ala Val Leu Leu 
1               5                   10                  15      


Thr Leu Gln Thr Pro Thr Gly Gln Ile His Trp Gly Asn Leu Ser Lys 
            20                  25                  30          


Ile Gly Val Val Gly Ile Gly Ser Ala Ser Tyr Lys Val Met Thr Arg 
        35                  40                  45              


Ser Ser His Gln Ser Leu Val Ile Lys Leu Met Pro Asn Ile Thr Leu 
    50                  55                  60                  


Leu Asn Asn Cys Thr Arg Val Glu Ile Ala Glu Tyr Arg Arg Leu Leu 
65                  70                  75                  80  


Arg Thr Val Leu Glu Pro Ile Arg Asp Ala Leu Asn Ala Met Thr Gln 
                85                  90                  95      


Asn Ile Arg Pro Val Gln Ser Val Ala Ser Ser Arg Arg His Lys Arg 
            100                 105                 110         


Phe Ala Gly Val Val Leu Ala Gly Ala Ala Leu Gly Val Ala Thr Ala 
        115                 120                 125             


Ala Gln Ile Thr Ala Gly Ile Ala Leu His Gln Ser Met Leu Asn Ser 
    130                 135                 140                 


Gln Ala Ile Asp Asn Leu Arg Ala Ser Leu Glu Thr Thr Asn Gln Ala 
145                 150                 155                 160 


Ile Glu Ala Ile Arg Gln Ala Gly Gln Glu Met Ile Leu Ala Val Gln 
                165                 170                 175     


Gly Val Gln Asp Tyr Ile Asn Asn Glu Leu Ile Pro Ser Met Asn Gln 
            180                 185                 190         


Leu Ser Cys Asp Leu Ile Gly Gln Lys Leu Gly Leu Lys Leu Leu Arg 
        195                 200                 205             


Tyr Tyr Thr Glu Ile Leu Ser Leu Phe Gly Pro Ser Leu Arg Asp Pro 
    210                 215                 220                 


Ile Ser Ala Glu Ile Ser Ile Gln Ala Leu Ser Tyr Ala Leu Gly Gly 
225                 230                 235                 240 


Asp Ile Asn Lys Val Leu Glu Lys Leu Gly Tyr Ser Gly Gly Asp Leu 
                245                 250                 255     


Leu Gly Ile Leu Glu Ser Arg Gly Ile Lys Ala Arg Ile Thr His Val 
            260                 265                 270         


Asp Thr Glu Ser Tyr Leu Ile Val Leu Ser Ile Ala Tyr Pro Thr Leu 
        275                 280                 285             


Ser Glu Ile Lys Gly Val Ile Val His Arg Leu Glu Gly Val Ser Tyr 
    290                 295                 300                 


Asn Ile Gly Ser Gln Glu Trp Tyr Thr Thr Val Pro Lys Tyr Val Ala 
305                 310                 315                 320 


Thr Gln Gly Tyr Leu Ile Ser Asn Phe Asp Glu Ser Ser Cys Thr Phe 
                325                 330                 335     


Met Pro Glu Gly Thr Val Cys Ser Gln Asn Ala Leu Tyr Pro Met Ser 
            340                 345                 350         


Pro Leu Leu Gln Glu Cys Leu Arg Gly Ser Thr Lys Ser Cys Ala Arg 
        355                 360                 365             


Thr Leu Val Ser Gly Ser Phe Gly Asn Arg Phe Ile Leu Ser Gln Gly 
    370                 375                 380                 


Asn Leu Ile Ala Asn Cys Ala Ser Ile Leu Cys Lys Cys Tyr Thr Thr 
385                 390                 395                 400 


Gly Thr Ile Ile Asn Gln Asp Pro Asp Lys Ile Leu Thr Tyr Ile Ala 
                405                 410                 415     


Ala Asp His Cys Pro Val Val Glu Val Asn Gly Val Thr Ile Gln Val 
            420                 425                 430         


Gly Ser Arg Arg Tyr Pro Asp Ala Val Tyr Leu His Arg Ile Asp Leu 
        435                 440                 445             


Gly Pro Pro Ile Leu Leu Glu Arg Leu Asp Val Gly Thr Asn Leu Gly 
    450                 455                 460                 


Asn Ala Ile Ala Lys Leu Glu Asp Ala Lys Glu Leu Leu Glu Ser Ser 
465                 470                 475                 480 


Asp Gln Ile Leu Arg Ser Met Lys Gly Leu Ser Ser Thr Cys Ile Val 
                485                 490                 495     


Tyr Ile Leu Ile Ala Val Cys Leu Gly Gly Leu Ile Gly Ile Pro Ala 
            500                 505                 510         


Leu Ile Cys Cys Cys Arg Gly Arg Cys Asn Lys Lys Gly Glu Gln Val 
        515                 520                 525             


Gly Met Ser Arg Pro Gly Leu Lys Pro Asp Leu Thr Gly Thr Ser Lys 
    530                 535                 540                 


Ser Tyr Val Arg Ser Leu 
545                 550 


<210>  133
<211>  538
<212>  PRT
<213>  Turkey rhinotracheitis virus

<400>  133

Met Asp Val Arg Ile Cys Leu Leu Leu Phe Leu Ile Ser Asn Pro Ser 
1               5                   10                  15      


Ser Cys Ile Gln Glu Thr Tyr Asn Glu Glu Ser Cys Ser Thr Val Thr 
            20                  25                  30          


Arg Gly Tyr Lys Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe 
        35                  40                  45              


Asn Leu Glu Ile Gly Asn Val Glu Asn Ile Thr Cys Asn Asp Gly Pro 
    50                  55                  60                  


Ser Leu Ile Asp Thr Glu Leu Val Leu Thr Lys Asn Ala Leu Arg Glu 
65                  70                  75                  80  


Leu Lys Thr Val Ser Ala Asp Gln Val Ala Lys Glu Ser Arg Leu Ser 
                85                  90                  95      


Ser Pro Arg Arg Arg Arg Phe Val Leu Gly Ala Ile Ala Leu Gly Val 
            100                 105                 110         


Ala Thr Ala Ala Ala Val Thr Ala Gly Val Ala Leu Ala Lys Thr Ile 
        115                 120                 125             


Arg Leu Glu Gly Glu Val Lys Ala Ile Lys Asn Ala Leu Arg Asn Thr 
    130                 135                 140                 


Asn Glu Ala Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Thr 
145                 150                 155                 160 


Ala Val Asn Asp Leu Lys Glu Phe Ile Ser Lys Lys Leu Thr Pro Ala 
                165                 170                 175     


Ile Asn Gln Asn Lys Cys Asn Ile Ala Asp Ile Lys Met Ala Ile Ser 
            180                 185                 190         


Phe Gly Gln Asn Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser 
        195                 200                 205             


Asp Ser Ala Gly Ile Thr Ser Ala Val Ser Leu Asp Leu Met Thr Asp 
    210                 215                 220                 


Asp Glu Leu Val Arg Ala Ile Asn Arg Met Pro Thr Ser Ser Gly Gln 
225                 230                 235                 240 


Ile Ser Leu Met Leu Asn Asn Arg Ala Met Val Arg Arg Lys Gly Phe 
                245                 250                 255     


Gly Ile Leu Ile Gly Val Tyr Asp Gly Thr Val Val Tyr Met Val Gln 
            260                 265                 270         


Leu Pro Ile Phe Gly Val Ile Glu Thr Pro Cys Trp Arg Val Val Ala 
        275                 280                 285             


Ala Pro Leu Cys Arg Lys Glu Lys Gly Asn Tyr Ala Cys Ile Leu Arg 
    290                 295                 300                 


Glu Asp Gln Gly Trp Tyr Cys Thr Asn Ala Gly Ser Thr Ala Tyr Tyr 
305                 310                 315                 320 


Pro Asn Lys Asp Asp Cys Glu Val Arg Asp Asp Tyr Val Phe Cys Asp 
                325                 330                 335     


Thr Ala Ala Gly Ile Asn Val Ala Leu Glu Val Glu Gln Cys Asn Tyr 
            340                 345                 350         


Asn Ile Ser Thr Ser Lys Tyr Pro Cys Lys Val Ser Thr Gly Arg His 
        355                 360                 365             


Pro Val Ser Met Val Ala Leu Thr Pro Leu Gly Gly Leu Val Ser Cys 
    370                 375                 380                 


Tyr Glu Ser Val Ser Cys Ser Ile Gly Ser Asn Lys Val Gly Ile Ile 
385                 390                 395                 400 


Lys Gln Leu Gly Lys Gly Cys Thr His Ile Pro Asn Asn Glu Ala Asp 
                405                 410                 415     


Thr Ile Thr Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Val Gly 
            420                 425                 430         


Glu Gln Arg Thr Ile Lys Gly Ala Pro Val Val Asn Asn Phe Asn Pro 
        435                 440                 445             


Ile Leu Phe Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe 
    450                 455                 460                 


Glu Ser Ile Asp Arg Ser Gln Asp Leu Ile Asp Lys Ser Asn Asp Leu 
465                 470                 475                 480 


Leu Gly Ala Asp Ala Lys Ser Lys Ala Gly Ile Ala Ile Ala Ile Val 
                485                 490                 495     


Val Leu Val Ile Leu Gly Ile Phe Phe Leu Leu Ala Val Ile Tyr Tyr 
            500                 505                 510         


Cys Ser Arg Val Arg Lys Thr Lys Pro Lys His Asp Tyr Pro Ala Thr 
        515                 520                 525             


Thr Gly His Ser Ser Met Ala Tyr Val Ser 
    530                 535             


<210>  134
<211>  551
<212>  PRT
<213>  Human parainfluenza 2 virus

<400>  134

Met His His Leu His Pro Met Ile Val Cys Ile Phe Val Met Tyr Thr 
1               5                   10                  15      


Gly Ile Val Gly Ser Asp Ala Ile Ala Gly Asp Gln Leu Leu Asn Ile 
            20                  25                  30          


Gly Val Ile Gln Ser Lys Ile Arg Ser Leu Met Tyr Tyr Thr Asp Gly 
        35                  40                  45              


Gly Ala Ser Phe Ile Val Val Lys Leu Leu Pro Asn Leu Pro Pro Ser 
    50                  55                  60                  


Asn Gly Thr Cys Asn Ile Thr Ser Leu Asp Ala Tyr Asn Val Thr Leu 
65                  70                  75                  80  


Phe Lys Leu Leu Thr Pro Leu Ile Glu Asn Leu Ser Lys Ile Ser Thr 
                85                  90                  95      


Val Thr Asp Thr Lys Thr Arg Gln Lys Arg Phe Ala Gly Val Val Val 
            100                 105                 110         


Gly Leu Ala Ala Leu Gly Val Ala Thr Ala Ala Gln Ile Thr Ala Ala 
        115                 120                 125             


Val Ala Ile Val Lys Ala Asn Ala Asn Ala Ala Ala Ile Asn Asn Leu 
    130                 135                 140                 


Ala Ser Ser Ile Gln Ser Thr Asn Lys Ala Val Ser Asp Val Ile Asp 
145                 150                 155                 160 


Ala Ser Arg Thr Ile Ala Thr Ala Val Gln Ala Ile Gln Asp His Ile 
                165                 170                 175     


Asn Gly Ala Ile Val Asn Gly Ile Thr Ser Ala Ser Cys Arg Ala His 
            180                 185                 190         


Asp Ala Leu Ile Gly Ser Ile Leu Asn Leu Tyr Leu Thr Glu Leu Thr 
        195                 200                 205             


Thr Ile Phe His Asn Gln Ile Thr Asn Pro Ala Leu Thr Pro Leu Ser 
    210                 215                 220                 


Ile Gln Ala Leu Arg Ile Leu Leu Gly Ser Thr Leu Pro Ile Val Ile 
225                 230                 235                 240 


Glu Ser Lys Leu Asn Thr Asn Leu Asn Thr Ala Glu Leu Leu Ser Ser 
                245                 250                 255     


Gly Leu Leu Thr Gly Gln Ile Ile Ser Ile Ser Pro Met Tyr Met Gln 
            260                 265                 270         


Met Leu Ile Gln Ile Asn Val Pro Thr Phe Ile Met Gln Pro Gly Ala 
        275                 280                 285             


Lys Val Ile Asp Leu Ile Ala Ile Ser Ala Asn His Lys Leu Gln Glu 
    290                 295                 300                 


Val Val Val Gln Val Pro Asn Arg Ile Leu Glu Tyr Ala Asn Glu Leu 
305                 310                 315                 320 


Gln Asn Tyr Pro Ala Asn Asp Cys Val Val Thr Pro Asn Ser Val Cys 
                325                 330                 335     


Cys Arg Tyr Asn Glu Gly Ser Pro Ile Pro Glu Ser Gln Tyr Gln Cys 
            340                 345                 350         


Leu Arg Gly Asn Leu Asn Ser Cys Thr Phe Thr Pro Ile Ile Gly Asn 
        355                 360                 365             


Phe Leu Lys Arg Phe Ala Phe Ala Asn Gly Val Leu Tyr Ala Asn Cys 
    370                 375                 380                 


Lys Ser Leu Leu Cys Arg Cys Ala Asp Pro Pro His Val Val Ser Gln 
385                 390                 395                 400 


Asp Asp Thr Gln Gly Ile Ser Ile Ile Asp Ile Lys Arg Cys Ser Glu 
                405                 410                 415     


Met Met Leu Asp Thr Phe Ser Phe Arg Ile Thr Ser Thr Phe Asn Ala 
            420                 425                 430         


Thr Tyr Val Thr Asp Phe Ser Met Ile Asn Ala Asn Ile Val His Leu 
        435                 440                 445             


Ser Pro Leu Asp Leu Ser Asn Gln Ile Asn Ser Ile Asn Lys Ser Leu 
    450                 455                 460                 


Lys Ser Ala Glu Asp Trp Ile Ala Asp Ser Asn Phe Phe Ala Asn Gln 
465                 470                 475                 480 


Ala Arg Thr Ala Lys Thr Leu Tyr Ser Leu Ser Ala Ile Ala Leu Ile 
                485                 490                 495     


Leu Ser Val Ile Thr Leu Val Val Val Gly Leu Leu Ile Ala Tyr Ile 
            500                 505                 510         


Ile Lys Leu Val Ser Gln Ile His Gln Phe Arg Ser Leu Ala Ala Thr 
        515                 520                 525             


Thr Met Phe His Arg Glu Asn Pro Ala Phe Phe Ser Lys Asn Asn His 
    530                 535                 540                 


Gly Asn Ile Tyr Gly Ile Ser 
545                 550     


<210>  135
<211>  546
<212>  PRT
<213>  Hendra virus

<400>  135

Met Ala Thr Gln Glu Val Arg Leu Lys Cys Leu Leu Cys Gly Ile Ile 
1               5                   10                  15      


Val Leu Val Leu Ser Leu Glu Gly Leu Gly Ile Leu His Tyr Glu Lys 
            20                  25                  30          


Leu Ser Lys Ile Gly Leu Val Lys Gly Ile Thr Arg Lys Tyr Lys Ile 
        35                  40                  45              


Lys Ser Asn Pro Leu Thr Lys Asp Ile Val Ile Lys Met Ile Pro Asn 
    50                  55                  60                  


Val Ser Asn Val Ser Lys Cys Thr Gly Thr Val Met Glu Asn Tyr Lys 
65                  70                  75                  80  


Ser Arg Leu Thr Gly Ile Leu Ser Pro Ile Lys Gly Ala Ile Glu Leu 
                85                  90                  95      


Tyr Asn Asn Asn Thr His Asp Leu Val Gly Asp Val Lys Leu Ala Gly 
            100                 105                 110         


Val Val Met Ala Gly Ile Ala Ile Gly Ile Ala Thr Ala Ala Gln Ile 
        115                 120                 125             


Thr Ala Gly Val Ala Leu Tyr Glu Ala Met Lys Asn Ala Asp Asn Ile 
    130                 135                 140                 


Asn Lys Leu Lys Ser Ser Ile Glu Ser Thr Asn Glu Ala Val Val Lys 
145                 150                 155                 160 


Leu Gln Glu Thr Ala Glu Lys Thr Val Tyr Val Leu Thr Ala Leu Gln 
                165                 170                 175     


Asp Tyr Ile Asn Thr Asn Leu Val Pro Thr Ile Asp Gln Ile Ser Cys 
            180                 185                 190         


Lys Gln Thr Glu Leu Ala Leu Asp Leu Ala Leu Ser Lys Tyr Leu Ser 
        195                 200                 205             


Asp Leu Leu Phe Val Phe Gly Pro Asn Leu Gln Asp Pro Val Ser Asn 
    210                 215                 220                 


Ser Met Thr Ile Gln Ala Ile Ser Gln Ala Phe Gly Gly Asn Tyr Glu 
225                 230                 235                 240 


Thr Leu Leu Arg Thr Leu Gly Tyr Ala Thr Glu Asp Phe Asp Asp Leu 
                245                 250                 255     


Leu Glu Ser Asp Ser Ile Ala Gly Gln Ile Val Tyr Val Asp Leu Ser 
            260                 265                 270         


Ser Tyr Tyr Ile Ile Val Arg Val Tyr Phe Pro Ile Leu Thr Glu Ile 
        275                 280                 285             


Gln Gln Ala Tyr Val Gln Glu Leu Leu Pro Val Ser Phe Asn Asn Asp 
    290                 295                 300                 


Asn Ser Glu Trp Ile Ser Ile Val Pro Asn Phe Val Leu Ile Arg Asn 
305                 310                 315                 320 


Thr Leu Ile Ser Asn Ile Glu Val Lys Tyr Cys Leu Ile Thr Lys Lys 
                325                 330                 335     


Ser Val Ile Cys Asn Gln Asp Tyr Ala Thr Pro Met Thr Ala Ser Val 
            340                 345                 350         


Arg Glu Cys Leu Thr Gly Ser Thr Asp Lys Cys Pro Arg Glu Leu Val 
        355                 360                 365             


Val Ser Ser His Val Pro Arg Phe Ala Leu Ser Gly Gly Val Leu Phe 
    370                 375                 380                 


Ala Asn Cys Ile Ser Val Thr Cys Gln Cys Gln Thr Thr Gly Arg Ala 
385                 390                 395                 400 


Ile Ser Gln Ser Gly Glu Gln Thr Leu Leu Met Ile Asp Asn Thr Thr 
                405                 410                 415     


Cys Thr Thr Val Val Leu Gly Asn Ile Ile Ile Ser Leu Gly Lys Tyr 
            420                 425                 430         


Leu Gly Ser Ile Asn Tyr Asn Ser Glu Ser Ile Ala Val Gly Pro Pro 
        435                 440                 445             


Val Tyr Thr Asp Lys Val Asp Ile Ser Ser Gln Ile Ser Ser Met Asn 
    450                 455                 460                 


Gln Ser Leu Gln Gln Ser Lys Asp Tyr Ile Lys Glu Ala Gln Lys Ile 
465                 470                 475                 480 


Leu Asp Thr Val Asn Pro Ser Leu Ile Ser Met Leu Ser Met Ile Ile 
                485                 490                 495     


Leu Tyr Val Leu Ser Ile Ala Ala Leu Cys Ile Gly Leu Ile Thr Phe 
            500                 505                 510         


Ile Ser Phe Val Ile Val Glu Lys Lys Arg Gly Asn Tyr Ser Arg Leu 
        515                 520                 525             


Asp Asp Arg Gln Val Arg Pro Val Ser Asn Gly Asp Leu Tyr Tyr Ile 
    530                 535                 540                 


Gly Thr 
545     


<210>  136
<211>  539
<212>  PRT
<213>  Human metapneumovirus

<400>  136

Met Ser Trp Lys Val Val Ile Ile Phe Ser Leu Leu Ile Thr Pro Gln 
1               5                   10                  15      


His Gly Leu Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr 
            20                  25                  30          


Glu Gly Tyr Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe 
        35                  40                  45              


Thr Leu Glu Val Gly Asp Val Glu Asn Leu Thr Cys Ser Asp Gly Pro 
    50                  55                  60                  


Ser Leu Ile Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu 
65                  70                  75                  80  


Leu Lys Thr Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu 
                85                  90                  95      


Asn Pro Arg Gln Ser Arg Phe Val Leu Gly Ala Ile Ala Leu Gly Val 
            100                 105                 110         


Ala Thr Ala Ala Ala Val Thr Ala Gly Val Ala Ile Ala Lys Thr Ile 
        115                 120                 125             


Arg Leu Glu Ser Glu Val Thr Ala Ile Lys Asn Ala Leu Lys Thr Thr 
    130                 135                 140                 


Asn Glu Ala Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Thr 
145                 150                 155                 160 


Ala Val Arg Glu Leu Lys Asp Phe Val Ser Lys Asn Leu Thr Arg Ala 
                165                 170                 175     


Ile Asn Lys Asn Lys Cys Asp Ile Asp Asp Leu Lys Met Ala Val Ser 
            180                 185                 190         


Phe Ser Gln Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser 
        195                 200                 205             


Asp Asn Ala Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp 
    210                 215                 220                 


Ala Glu Leu Ala Arg Ala Val Ser Asn Met Pro Thr Ser Ala Gly Gln 
225                 230                 235                 240 


Ile Lys Leu Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe 
                245                 250                 255     


Gly Ile Leu Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln 
            260                 265                 270         


Leu Pro Ile Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Val Lys Ala 
        275                 280                 285             


Ala Pro Ser Cys Ser Gly Lys Lys Gly Asn Tyr Ala Cys Leu Leu Arg 
    290                 295                 300                 


Glu Asp Gln Gly Trp Tyr Cys Gln Asn Ala Gly Ser Thr Val Tyr Tyr 
305                 310                 315                 320 


Pro Asn Glu Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp 
                325                 330                 335     


Thr Ala Ala Gly Ile Asn Val Ala Glu Gln Ser Lys Glu Cys Asn Ile 
            340                 345                 350         


Asn Ile Ser Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His 
        355                 360                 365             


Pro Ile Ser Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys 
    370                 375                 380                 


Tyr Lys Gly Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile 
385                 390                 395                 400 


Lys Gln Leu Asn Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp 
                405                 410                 415     


Thr Val Thr Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly 
            420                 425                 430         


Glu Gln His Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro 
        435                 440                 445             


Ile Lys Phe Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe 
    450                 455                 460                 


Glu Asn Ile Glu Asn Ser Gln Ala Leu Val Asp Gln Ser Asn Arg Ile 
465                 470                 475                 480 


Leu Ser Ser Ala Glu Lys Gly Asn Thr Gly Phe Ile Ile Val Ile Ile 
                485                 490                 495     


Leu Ile Ala Val Leu Gly Ser Ser Met Ile Leu Val Ser Ile Phe Ile 
            500                 505                 510         


Ile Ile Lys Lys Thr Lys Lys Pro Thr Gly Ala Pro Pro Glu Leu Ser 
        515                 520                 525             


Gly Val Thr Asn Asn Gly Phe Ile Pro His Ser 
    530                 535                 


<210>  137
<211>  574
<212>  PRT
<213>  Bovine respiratory syncytial virus

<400>  137

Met Ala Ala Thr Ala Met Arg Met Ile Ile Ser Ile Ile Phe Ile Ser 
1               5                   10                  15      


Thr Tyr Met Thr His Ile Thr Leu Cys Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          


Tyr Gln Ser Thr Cys Ser Ala Val Ser Arg Gly Tyr Leu Ser Ala Leu 
        35                  40                  45              


Arg Thr Gly Trp Tyr Thr Ser Val Val Thr Ile Glu Leu Ser Lys Ile 
    50                  55                  60                  


Gln Lys Asn Val Cys Lys Ser Thr Asp Ser Lys Val Lys Leu Ile Lys 
65                  70                  75                  80  


Gln Glu Leu Glu Arg Tyr Asn Asn Ala Val Ile Glu Leu Gln Ser Leu 
                85                  90                  95      


Met Gln Asn Glu Pro Ala Ser Phe Ser Arg Ala Lys Arg Gly Ile Pro 
            100                 105                 110         


Glu Leu Ile His Tyr Thr Arg Asn Ser Thr Lys Arg Phe Tyr Gly Leu 
        115                 120                 125             


Met Gly Lys Lys Arg Lys Arg Arg Phe Leu Gly Phe Leu Leu Gly Ile 
    130                 135                 140                 


Gly Ser Ala Ile Ala Ser Gly Val Ala Val Ser Lys Val Leu His Leu 
145                 150                 155                 160 


Glu Gly Glu Val Asn Lys Ile Lys Asn Ala Leu Leu Ser Thr Asn Lys 
                165                 170                 175     


Ala Val Val Ser Leu Ser Asn Gly Val Ser Val Leu Thr Ser Lys Val 
            180                 185                 190         


Leu Asp Leu Lys Asn Tyr Ile Asp Lys Glu Leu Leu Pro Lys Val Asn 
        195                 200                 205             


Asn His Asp Cys Arg Ile Ser Asn Ile Glu Thr Val Ile Glu Phe Gln 
    210                 215                 220                 


Gln Lys Asn Asn Arg Leu Leu Glu Ile Ala Arg Glu Phe Ser Val Asn 
225                 230                 235                 240 


Ala Gly Ile Thr Thr Pro Leu Ser Thr Tyr Met Leu Thr Asn Ser Glu 
                245                 250                 255     


Leu Leu Ser Leu Ile Asn Asp Met Pro Ile Thr Asn Asp Gln Lys Lys 
            260                 265                 270         


Leu Met Ser Ser Asn Val Gln Ile Val Arg Gln Gln Ser Tyr Ser Ile 
        275                 280                 285             


Met Ser Val Val Lys Glu Glu Val Ile Ala Tyr Val Val Gln Leu Pro 
    290                 295                 300                 


Ile Tyr Gly Val Ile Asp Thr Pro Cys Trp Lys Leu His Thr Ser Pro 
305                 310                 315                 320 


Leu Cys Thr Thr Asp Asn Lys Glu Gly Ser Asn Ile Cys Leu Thr Arg 
                325                 330                 335     


Thr Asp Arg Gly Trp Tyr Cys Asp Asn Ala Gly Ser Val Ser Phe Phe 
            340                 345                 350         


Pro Gln Ala Glu Thr Cys Lys Val Gln Ser Asn Arg Val Phe Cys Asp 
        355                 360                 365             


Thr Met Asn Ser Leu Thr Leu Pro Thr Asp Val Asn Leu Cys Asn Thr 
    370                 375                 380                 


Asp Ile Phe Asn Thr Lys Tyr Asp Cys Lys Ile Met Thr Ser Lys Thr 
385                 390                 395                 400 


Asp Ile Ser Ser Ser Val Ile Thr Ser Ile Gly Ala Ile Val Ser Cys 
                405                 410                 415     


Tyr Gly Lys Thr Lys Cys Thr Ala Ser Asn Lys Asn Arg Gly Ile Ile 
            420                 425                 430         


Lys Thr Phe Ser Asn Gly Cys Asp Tyr Val Ser Asn Lys Gly Val Asp 
        435                 440                 445             


Thr Val Ser Val Gly Asn Thr Leu Tyr Tyr Val Asn Lys Leu Glu Gly 
    450                 455                 460                 


Lys Ala Leu Tyr Ile Lys Gly Glu Pro Ile Ile Asn Tyr Tyr Asp Pro 
465                 470                 475                 480 


Leu Val Phe Pro Ser Asp Glu Phe Asp Ala Ser Ile Ala Gln Val Asn 
                485                 490                 495     


Ala Lys Ile Asn Gln Ser Leu Ala Phe Ile Arg Arg Ser Asp Glu Leu 
            500                 505                 510         


Leu His Ser Val Asp Val Gly Lys Ser Thr Thr Asn Val Val Ile Thr 
        515                 520                 525             


Thr Ile Ile Ile Val Ile Val Val Val Ile Leu Met Leu Ile Ala Val 
    530                 535                 540                 


Gly Leu Leu Phe Tyr Cys Lys Thr Arg Ser Thr Pro Ile Met Leu Gly 
545                 550                 555                 560 


Lys Asp Gln Leu Ser Gly Ile Asn Asn Leu Ser Phe Ser Lys 
                565                 570                 


<210>  138
<211>  565
<212>  PRT
<213>  Sendai virus

<400>  138

Met Thr Ala Tyr Ile Gln Arg Ser Gln Cys Ile Ser Thr Ser Leu Leu 
1               5                   10                  15      


Val Val Leu Thr Thr Leu Val Ser Cys Gln Ile Pro Arg Asp Arg Leu 
            20                  25                  30          


Ser Asn Ile Gly Val Ile Val Asp Glu Gly Lys Ser Leu Lys Ile Ala 
        35                  40                  45              


Gly Ser His Glu Ser Arg Tyr Ile Val Leu Ser Leu Val Pro Gly Val 
    50                  55                  60                  


Asp Phe Glu Asn Gly Cys Gly Thr Ala Gln Val Ile Gln Tyr Lys Ser 
65                  70                  75                  80  


Leu Leu Asn Arg Leu Leu Ile Pro Leu Arg Asp Ala Leu Asp Leu Gln 
                85                  90                  95      


Glu Ala Leu Ile Thr Val Thr Asn Asp Thr Thr Gln Asn Ala Gly Ala 
            100                 105                 110         


Pro Gln Ser Arg Phe Phe Gly Ala Val Ile Gly Thr Ile Ala Leu Gly 
        115                 120                 125             


Val Ala Thr Ser Ala Gln Ile Thr Ala Gly Ile Ala Leu Ala Glu Ala 
    130                 135                 140                 


Arg Glu Ala Lys Arg Asp Ile Ala Leu Ile Lys Glu Ser Met Thr Lys 
145                 150                 155                 160 


Thr His Lys Ser Ile Glu Leu Leu Gln Asn Ala Val Gly Glu Gln Ile 
                165                 170                 175     


Leu Ala Leu Lys Thr Leu Gln Asp Phe Val Asn Asp Glu Ile Lys Pro 
            180                 185                 190         


Ala Ile Ser Glu Leu Gly Cys Glu Thr Ala Ala Leu Arg Leu Gly Ile 
        195                 200                 205             


Lys Leu Thr Gln His Tyr Ser Glu Leu Leu Thr Ala Phe Gly Ser Asn 
    210                 215                 220                 


Phe Gly Thr Ile Gly Glu Lys Ser Leu Thr Leu Gln Ala Leu Ser Ser 
225                 230                 235                 240 


Leu Tyr Ser Ala Asn Ile Thr Glu Ile Met Thr Thr Ile Lys Thr Gly 
                245                 250                 255     


Gln Ser Asn Ile Tyr Asp Val Ile Tyr Thr Glu Gln Ile Lys Gly Thr 
            260                 265                 270         


Val Ile Asp Val Asp Leu Glu Arg Tyr Met Val Thr Leu Ser Val Lys 
        275                 280                 285             


Ile Pro Ile Leu Ser Glu Val Pro Gly Val Leu Ile His Lys Ala Ser 
    290                 295                 300                 


Ser Ile Ser Tyr Asn Ile Asp Gly Glu Glu Trp Tyr Val Thr Val Pro 
305                 310                 315                 320 


Ser His Ile Leu Ser Arg Ala Ser Phe Leu Gly Gly Ala Asp Ile Thr 
                325                 330                 335     


Asp Cys Val Glu Ser Arg Leu Thr Tyr Ile Cys Pro Arg Asp Pro Ala 
            340                 345                 350         


Gln Leu Ile Pro Asp Ser Gln Gln Lys Cys Ile Leu Gly Asp Thr Thr 
        355                 360                 365             


Arg Cys Pro Val Thr Lys Val Val Asp Ser Leu Ile Pro Lys Phe Ala 
    370                 375                 380                 


Phe Val Asn Gly Gly Val Val Ala Asn Cys Ile Ala Ser Thr Cys Thr 
385                 390                 395                 400 


Cys Gly Thr Gly Arg Arg Pro Ile Ser Gln Asp Arg Ser Lys Gly Val 
                405                 410                 415     


Val Phe Leu Thr His Asp Asn Cys Gly Leu Ile Gly Val Asn Gly Val 
            420                 425                 430         


Glu Leu Tyr Ala Asn Arg Arg Gly His Asp Ala Thr Trp Gly Val Gln 
        435                 440                 445             


Asn Leu Thr Val Gly Pro Ala Ile Ala Ile Arg Pro Ile Asp Ile Ser 
    450                 455                 460                 


Leu Asn Leu Ala Asp Ala Thr Asn Phe Leu Gln Asp Ser Lys Ala Glu 
465                 470                 475                 480 


Leu Glu Lys Ala Arg Lys Ile Leu Ser Glu Val Gly Arg Trp Tyr Asn 
                485                 490                 495     


Ser Arg Glu Thr Val Ile Thr Ile Ile Val Val Met Val Val Ile Leu 
            500                 505                 510         


Val Val Ile Ile Val Ile Ile Ile Val Leu Tyr Arg Leu Arg Arg Ser 
        515                 520                 525             


Met Leu Met Gly Asn Pro Asp Asp Arg Ile Pro Arg Asp Thr Tyr Thr 
    530                 535                 540                 


Leu Glu Pro Lys Ile Arg His Met Tyr Thr Asn Gly Gly Phe Asp Ala 
545                 550                 555                 560 


Met Ala Glu Lys Arg 
                565 


<210>  139
<211>  539
<212>  PRT
<213>  Human parainfluenza 3 virus

<400>  139

Met Pro Thr Ser Ile Leu Leu Ile Ile Thr Thr Met Ile Met Ala Ser 
1               5                   10                  15      


Phe Cys Gln Ile Asp Ile Thr Lys Leu Gln His Val Gly Val Leu Val 
            20                  25                  30          


Asn Ser Pro Lys Gly Met Lys Ile Ser Gln Asn Phe Glu Thr Arg Tyr 
        35                  40                  45              


Leu Ile Leu Ser Leu Ile Pro Lys Ile Glu Asp Ser Asn Ser Cys Gly 
    50                  55                  60                  


Asp Gln Gln Ile Lys Gln Tyr Lys Arg Leu Leu Asp Arg Leu Ile Ile 
65                  70                  75                  80  


Pro Leu Tyr Asp Gly Leu Arg Leu Gln Lys Asp Val Ile Val Ser Asn 
                85                  90                  95      


Gln Glu Ser Asn Glu Asn Thr Asp Pro Arg Thr Lys Arg Phe Phe Gly 
            100                 105                 110         


Gly Val Ile Gly Thr Ile Ala Leu Gly Val Ala Thr Ser Ala Gln Ile 
        115                 120                 125             


Thr Ala Ala Val Ala Leu Val Glu Ala Lys Gln Ala Arg Ser Asp Ile 
    130                 135                 140                 


Glu Lys Leu Lys Glu Ala Ile Arg Asp Thr Asn Lys Ala Val Gln Ser 
145                 150                 155                 160 


Val Gln Ser Ser Ile Gly Asn Leu Ile Val Ala Ile Lys Ser Val Gln 
                165                 170                 175     


Asp Tyr Val Asn Lys Glu Ile Val Pro Ser Ile Ala Arg Leu Gly Cys 
            180                 185                 190         


Glu Ala Ala Gly Leu Gln Leu Gly Ile Ala Leu Thr Gln His Tyr Ser 
        195                 200                 205             


Glu Leu Thr Asn Ile Phe Gly Asp Asn Ile Gly Ser Leu Gln Glu Lys 
    210                 215                 220                 


Gly Ile Lys Leu Gln Gly Ile Ala Ser Leu Tyr Arg Thr Asn Ile Thr 
225                 230                 235                 240 


Glu Ile Phe Thr Thr Ser Thr Val Asp Lys Tyr Asp Ile Tyr Asp Leu 
                245                 250                 255     


Leu Phe Thr Glu Ser Ile Lys Val Arg Val Ile Asp Val Asp Leu Asn 
            260                 265                 270         


Asp Tyr Ser Ile Thr Leu Gln Val Arg Leu Pro Leu Leu Thr Arg Leu 
        275                 280                 285             


Leu Asn Thr Gln Ile Tyr Arg Val Asp Ser Ile Ser Tyr Asn Ile Gln 
    290                 295                 300                 


Asn Arg Glu Trp Tyr Ile Pro Leu Pro Ser His Ile Met Thr Lys Gly 
305                 310                 315                 320 


Ala Phe Leu Gly Gly Ala Asp Val Lys Glu Cys Ile Glu Ala Phe Ser 
                325                 330                 335     


Ser Tyr Ile Cys Pro Ser Asp Pro Gly Phe Val Leu Asn His Glu Met 
            340                 345                 350         


Glu Ser Cys Leu Ser Gly Asn Ile Ser Gln Cys Pro Arg Thr Val Val 
        355                 360                 365             


Lys Ser Asp Ile Val Pro Arg Tyr Ala Phe Val Asn Gly Gly Val Val 
    370                 375                 380                 


Ala Asn Cys Ile Thr Thr Thr Cys Thr Cys Asn Gly Ile Gly Asn Arg 
385                 390                 395                 400 


Ile Asn Gln Pro Pro Asp Gln Gly Val Lys Ile Ile Thr His Lys Glu 
                405                 410                 415     


Cys Asn Thr Ile Gly Ile Asn Gly Met Leu Phe Asn Thr Asn Lys Glu 
            420                 425                 430         


Gly Thr Leu Ala Phe Tyr Thr Pro Asn Asp Ile Thr Leu Asn Asn Ser 
        435                 440                 445             


Val Ala Leu Asp Pro Ile Asp Ile Ser Ile Glu Leu Asn Lys Ala Lys 
    450                 455                 460                 


Ser Asp Leu Glu Glu Ser Lys Glu Trp Ile Arg Arg Ser Asn Gln Lys 
465                 470                 475                 480 


Leu Asp Ser Ile Gly Asn Trp His Gln Ser Ser Thr Thr Ile Ile Ile 
                485                 490                 495     


Val Leu Ile Met Ile Ile Ile Leu Phe Ile Ile Asn Val Thr Ile Ile 
            500                 505                 510         


Ile Ile Ala Val Lys Tyr Tyr Arg Ile Gln Lys Arg Asn Arg Val Asp 
        515                 520                 525             


Gln Asn Asp Lys Pro Tyr Val Leu Thr Asn Lys 
    530                 535                 


<210>  140
<211>  538
<212>  PRT
<213>  Mumps virus

<400>  140

Met Lys Ala Phe Pro Val Ile Cys Leu Gly Phe Ala Ile Phe Ser Ser 
1               5                   10                  15      


Ser Ile Cys Val Asn Ile Asn Ile Leu Gln Gln Ile Gly Tyr Ile Lys 
            20                  25                  30          


Gln Gln Val Arg Gln Leu Ser Tyr Tyr Ser Gln Ser Ser Ser Ser Tyr 
        35                  40                  45              


Val Val Val Lys Leu Leu Pro Asn Ile Gln Pro Thr Asp Asn Ser Cys 
    50                  55                  60                  


Glu Phe Lys Ser Val Thr Gln Tyr Asn Lys Thr Leu Ser Asn Leu Leu 
65                  70                  75                  80  


Leu Pro Ile Ala Glu Asn Ile Asn Asn Ile Thr Ser Pro Ser Pro Gly 
                85                  90                  95      


Ser Arg Arg His Lys Arg Phe Ala Gly Ile Ala Ile Gly Ile Ala Ala 
            100                 105                 110         


Leu Gly Val Ala Thr Ala Ala Gln Val Thr Ala Ala Val Ser Leu Val 
        115                 120                 125             


Gln Ala Gln Thr Asn Ala Arg Ala Ile Ala Ala Met Lys Asn Ser Ile 
    130                 135                 140                 


Gln Ala Thr Asn Arg Ala Val Phe Glu Val Lys Glu Gly Thr Gln Gln 
145                 150                 155                 160 


Leu Ala Ile Ala Val Gln Ala Ile Gln Asp His Ile Asn Thr Ile Met 
                165                 170                 175     


Asn Thr Gln Leu Asn Asn Met Ser Cys Gln Ile Leu Asp Asn Gln Leu 
            180                 185                 190         


Ala Thr Ser Leu Gly Leu Tyr Leu Thr Glu Leu Thr Thr Val Phe Gln 
        195                 200                 205             


Pro Gln Leu Ile Asn Pro Ala Leu Ser Pro Ile Ser Ile Gln Ala Leu 
    210                 215                 220                 


Arg Ser Leu Leu Gly Ser Met Thr Pro Ala Val Val Gln Ala Thr Leu 
225                 230                 235                 240 


Ser Thr Ser Ile Ser Ala Ala Glu Ile Leu Ser Ala Gly Leu Met Glu 
                245                 250                 255     


Gly Gln Ile Val Ser Val Leu Leu Asp Glu Met Gln Met Ile Val Lys 
            260                 265                 270         


Ile Asn Val Pro Thr Ile Val Thr Gln Ser Asn Ala Leu Val Ile Asp 
        275                 280                 285             


Phe Tyr Ser Ile Ser Ser Phe Ile Asn Asn Gln Glu Ser Ile Ile Gln 
    290                 295                 300                 


Leu Pro Asp Arg Ile Leu Glu Ile Gly Asn Glu Gln Trp Arg Tyr Pro 
305                 310                 315                 320 


Ala Lys Asn Cys Lys Leu Thr Arg His His Ile Phe Cys Gln Tyr Asn 
                325                 330                 335     


Glu Ala Glu Arg Leu Ser Leu Glu Thr Lys Leu Cys Leu Ala Gly Asn 
            340                 345                 350         


Ile Ser Ala Cys Val Phe Ser Ser Ile Ala Gly Ser Tyr Met Arg Arg 
        355                 360                 365             


Phe Val Ala Leu Asp Gly Thr Ile Val Ala Asn Cys Arg Ser Leu Thr 
    370                 375                 380                 


Cys Leu Cys Lys Ser Pro Ser Tyr Pro Ile Tyr Gln Pro Asp His His 
385                 390                 395                 400 


Ala Val Thr Thr Ile Asp Leu Thr Ser Cys Gln Thr Leu Ser Leu Asp 
                405                 410                 415     


Gly Leu Asp Phe Ser Ile Val Ser Leu Ser Asn Ile Thr Tyr Ala Glu 
            420                 425                 430         


Asn Leu Thr Ile Ser Leu Ser Gln Thr Ile Asn Thr Gln Pro Ile Asp 
        435                 440                 445             


Ile Ser Thr Glu Leu Ser Lys Val Asn Ala Ser Leu Gln Asn Ala Val 
    450                 455                 460                 


Lys Tyr Ile Lys Glu Ser Asn His Gln Leu Gln Ser Val Ser Val Ser 
465                 470                 475                 480 


Ser Lys Ile Gly Ala Ile Ile Val Ala Ala Leu Val Leu Ser Ile Leu 
                485                 490                 495     


Ser Ile Ile Ile Ser Leu Leu Phe Cys Phe Trp Ala Tyr Ile Ala Thr 
            500                 505                 510         


Lys Glu Ile Arg Arg Ile Asn Phe Lys Thr Asn His Ile Asn Thr Ile 
        515                 520                 525             


Ser Ser Ser Val Asp Asp Leu Ile Arg Tyr 
    530                 535             


<210>  141
<211>  550
<212>  PRT
<213>  Measles virus

<400>  141

Met Gly Leu Lys Val Asn Val Ser Ala Ile Phe Met Ala Val Leu Leu 
1               5                   10                  15      


Thr Leu Gln Thr Pro Thr Gly Gln Ile His Trp Gly Asn Leu Ser Lys 
            20                  25                  30          


Ile Gly Val Val Gly Ile Gly Ser Ala Ser Tyr Lys Val Met Thr Arg 
        35                  40                  45              


Ser Ser His Gln Ser Leu Val Ile Lys Leu Met Pro Asn Ile Thr Leu 
    50                  55                  60                  


Leu Asn Asn Cys Thr Arg Val Glu Ile Ala Glu Tyr Arg Arg Leu Leu 
65                  70                  75                  80  


Arg Thr Val Leu Glu Pro Ile Arg Asp Ala Leu Asn Ala Met Thr Gln 
                85                  90                  95      


Asn Ile Arg Pro Val Gln Ser Val Ala Ser Ser Arg Arg His Lys Arg 
            100                 105                 110         


Phe Ala Gly Val Val Leu Ala Gly Ala Ala Leu Gly Val Ala Thr Ala 
        115                 120                 125             


Ala Gln Ile Thr Ala Gly Ile Ala Leu His Gln Ser Met Leu Asn Ser 
    130                 135                 140                 


Gln Ala Ile Asp Asn Leu Arg Ala Ser Leu Glu Thr Thr Asn Gln Ala 
145                 150                 155                 160 


Ile Glu Ala Ile Arg Gln Ala Gly Gln Glu Met Ile Leu Ala Val Gln 
                165                 170                 175     


Gly Val Gln Asp Tyr Ile Asn Asn Glu Leu Ile Pro Ser Met Asn Gln 
            180                 185                 190         


Leu Ser Cys Asp Leu Ile Gly Gln Lys Leu Gly Leu Lys Leu Leu Arg 
        195                 200                 205             


Tyr Tyr Thr Glu Ile Leu Ser Leu Phe Gly Pro Ser Leu Arg Asp Pro 
    210                 215                 220                 


Ile Ser Ala Glu Ile Ser Ile Gln Ala Leu Ser Tyr Ala Leu Gly Gly 
225                 230                 235                 240 


Asp Ile Asn Lys Val Leu Glu Lys Leu Gly Tyr Ser Gly Gly Asp Leu 
                245                 250                 255     


Leu Gly Ile Leu Glu Ser Arg Gly Ile Lys Ala Arg Ile Thr His Val 
            260                 265                 270         


Asp Thr Glu Ser Tyr Phe Ile Val Leu Ser Ile Ala Tyr Pro Thr Leu 
        275                 280                 285             


Ser Glu Ile Lys Gly Val Ile Val His Arg Leu Glu Gly Val Ser Tyr 
    290                 295                 300                 


Asn Ile Gly Ser Gln Glu Trp Tyr Thr Thr Val Pro Lys Tyr Val Ala 
305                 310                 315                 320 


Thr Gln Gly Tyr Leu Ile Ser Asn Phe Asp Glu Ser Ser Cys Thr Phe 
                325                 330                 335     


Met Pro Glu Gly Thr Val Cys Ser Gln Asn Ala Leu Tyr Pro Met Ser 
            340                 345                 350         


Pro Leu Leu Gln Glu Cys Leu Arg Gly Ser Thr Lys Ser Cys Ala Arg 
        355                 360                 365             


Thr Leu Val Ser Gly Ser Phe Gly Asn Arg Phe Ile Leu Ser Gln Gly 
    370                 375                 380                 


Asn Leu Ile Ala Asn Cys Ala Ser Ile Leu Cys Lys Cys Tyr Thr Thr 
385                 390                 395                 400 


Gly Thr Ile Ile Asn Gln Asp Pro Asp Lys Ile Leu Thr Tyr Ile Ala 
                405                 410                 415     


Ala Asp His Cys Pro Val Val Glu Val Asn Gly Val Thr Ile Gln Val 
            420                 425                 430         


Gly Ser Arg Arg Tyr Pro Asp Ala Val Tyr Leu His Arg Ile Asp Leu 
        435                 440                 445             


Gly Pro Pro Ile Ser Leu Glu Arg Leu Asp Val Gly Thr Asn Leu Gly 
    450                 455                 460                 


Asn Ala Ile Ala Lys Leu Glu Asp Ala Lys Glu Leu Leu Glu Ser Ser 
465                 470                 475                 480 


Asp Gln Ile Leu Arg Ser Met Lys Gly Leu Ser Ser Thr Ser Ile Val 
                485                 490                 495     


Tyr Ile Leu Ile Ala Val Cys Leu Gly Gly Leu Ile Gly Ile Pro Ala 
            500                 505                 510         


Leu Ile Cys Cys Cys Arg Gly Arg Cys Asn Lys Lys Gly Glu Gln Val 
        515                 520                 525             


Gly Met Ser Arg Pro Gly Leu Lys Pro Asp Leu Thr Gly Thr Ser Lys 
    530                 535                 540                 


Ser Tyr Val Arg Ser Leu 
545                 550 


<210>  142
<211>  555
<212>  PRT
<213>  Human parainfluenza 1 virus

<400>  142

Met Gln Lys Ser Glu Ile Leu Phe Leu Ile Tyr Ser Ser Leu Leu Leu 
1               5                   10                  15      


Ser Ser Ser Leu Cys Gln Ile Pro Val Asp Lys Leu Ser Asn Val Gly 
            20                  25                  30          


Val Ile Ile Asn Glu Gly Lys Leu Leu Lys Ile Ala Gly Ser Tyr Glu 
        35                  40                  45              


Ser Arg Tyr Ile Val Leu Ser Leu Val Pro Ser Ile Asp Leu Glu Asp 
    50                  55                  60                  


Gly Cys Gly Thr Thr Gln Ile Ile Gln Tyr Lys Asn Leu Leu Asn Arg 
65                  70                  75                  80  


Leu Leu Ile Pro Leu Lys Asp Ala Leu Asp Leu Gln Glu Ser Leu Ile 
                85                  90                  95      


Thr Ile Thr Asn Asp Thr Thr Val Thr Asn Asp Asn Pro Gln Ser Arg 
            100                 105                 110         


Phe Phe Gly Ala Val Ile Gly Thr Ile Ala Leu Gly Val Ala Thr Ala 
        115                 120                 125             


Ala Gln Ile Thr Ala Gly Ile Ala Leu Ala Glu Ala Arg Glu Ala Arg 
    130                 135                 140                 


Lys Asp Ile Ala Leu Ile Lys Asp Ser Ile Ile Lys Thr His Asn Ser 
145                 150                 155                 160 


Val Glu Leu Ile Gln Arg Gly Ile Gly Glu Gln Ile Ile Ala Leu Lys 
                165                 170                 175     


Thr Leu Gln Asp Phe Val Asn Asn Glu Ile Arg Pro Ala Ile Gly Glu 
            180                 185                 190         


Leu Arg Cys Glu Thr Thr Ala Leu Lys Leu Gly Ile Lys Leu Thr Gln 
        195                 200                 205             


His Tyr Ser Glu Leu Ala Thr Ala Phe Ser Ser Asn Leu Gly Thr Ile 
    210                 215                 220                 


Gly Glu Lys Ser Leu Thr Leu Gln Ala Leu Ser Ser Leu Tyr Ser Ala 
225                 230                 235                 240 


Asn Ile Thr Glu Ile Leu Ser Thr Ile Lys Lys Asp Lys Ser Asp Ile 
                245                 250                 255     


Tyr Asp Ile Ile Tyr Thr Glu Gln Val Lys Gly Thr Val Ile Asp Val 
            260                 265                 270         


Asp Leu Glu Lys Tyr Met Val Thr Leu Leu Val Lys Ile Pro Ile Leu 
        275                 280                 285             


Ser Glu Ile Pro Gly Val Leu Ile Tyr Arg Ala Ser Ser Ile Ser Tyr 
    290                 295                 300                 


Asn Ile Glu Gly Glu Glu Trp His Val Ala Ile Pro Asn Tyr Ile Ile 
305                 310                 315                 320 


Asn Lys Ala Ser Ser Leu Gly Gly Ala Asp Val Thr Asn Cys Ile Glu 
                325                 330                 335     


Ser Arg Leu Ala Tyr Ile Cys Pro Arg Asp Pro Thr Gln Leu Ile Pro 
            340                 345                 350         


Asp Asn Gln Gln Lys Cys Ile Leu Gly Asp Val Ser Lys Cys Pro Val 
        355                 360                 365             


Thr Lys Val Ile Asn Asn Leu Val Pro Lys Phe Ala Phe Ile Asn Gly 
    370                 375                 380                 


Gly Val Val Ala Asn Cys Ile Ala Ser Thr Cys Thr Cys Gly Thr Asn 
385                 390                 395                 400 


Arg Ile Pro Val Asn Gln Asp Arg Ser Arg Gly Val Thr Phe Leu Thr 
                405                 410                 415     


Tyr Thr Asn Cys Gly Leu Ile Gly Ile Asn Gly Ile Glu Leu Tyr Ala 
            420                 425                 430         


Asn Lys Arg Gly Arg Asp Thr Thr Trp Gly Asn Gln Ile Ile Lys Val 
        435                 440                 445             


Gly Pro Ala Val Ser Ile Arg Pro Val Asp Ile Ser Leu Asn Leu Ala 
    450                 455                 460                 


Ser Ala Thr Asn Phe Leu Glu Glu Ser Lys Ile Glu Leu Met Lys Ala 
465                 470                 475                 480 


Lys Ala Ile Ile Ser Ala Val Gly Gly Trp His Asn Thr Glu Ser Thr 
                485                 490                 495     


Gln Ile Ile Ile Ile Ile Ile Val Cys Ile Leu Ile Ile Ile Ile Cys 
            500                 505                 510         


Gly Ile Leu Tyr Tyr Leu Tyr Arg Val Arg Arg Leu Leu Val Met Ile 
        515                 520                 525             


Asn Ser Thr His Asn Ser Pro Val Asn Thr Tyr Thr Leu Glu Ser Arg 
    530                 535                 540                 


Met Arg Asn Pro Tyr Ile Gly Asn Asn Ser Asn 
545                 550                 555 


<210>  143
<211>  565
<212>  PRT
<213>  Sendai virus

<400>  143

Met Ala Thr Tyr Ile Gln Arg Val Gln Cys Ile Ser Ala Leu Leu Ser 
1               5                   10                  15      


Val Val Leu Thr Thr Leu Val Ser Cys Gln Ile Pro Arg Asp Arg Leu 
            20                  25                  30          


Ser Asn Ile Gly Val Ile Val Asp Glu Gly Lys Ser Leu Lys Ile Ala 
        35                  40                  45              


Gly Ser His Glu Ser Arg Tyr Ile Val Leu Ser Leu Val Pro Gly Val 
    50                  55                  60                  


Asp Leu Glu Asn Gly Cys Gly Thr Ala Gln Val Ile Gln Tyr Lys Ser 
65                  70                  75                  80  


Leu Leu Asn Arg Leu Leu Ile Pro Leu Arg Asp Ala Leu Asp Leu Gln 
                85                  90                  95      


Glu Ala Leu Ile Thr Val Thr Asn Asp Thr Met Thr Ser Ala Asp Val 
            100                 105                 110         


Pro Gln Ser Arg Phe Phe Gly Ala Val Ile Gly Thr Ile Ala Leu Gly 
        115                 120                 125             


Val Ala Thr Ser Ala Gln Ile Thr Ala Gly Ile Ala Leu Ala Glu Ala 
    130                 135                 140                 


Arg Glu Ala Lys Arg Asp Ile Ala Leu Ile Lys Glu Ser Met Thr Lys 
145                 150                 155                 160 


Thr His Lys Ser Ile Glu Leu Leu Gln Asn Ala Val Gly Glu Gln Ile 
                165                 170                 175     


Leu Ala Leu Lys Thr Leu Gln Asp Phe Val Asn Asp Glu Ile Lys Pro 
            180                 185                 190         


Ala Ile Ser Glu Leu Gly Cys Glu Thr Ala Ala Leu Arg Leu Gly Ile 
        195                 200                 205             


Lys Leu Thr Gln His Tyr Ser Glu Leu Leu Thr Ala Phe Gly Ser Asn 
    210                 215                 220                 


Phe Gly Thr Ile Gly Glu Lys Ser Leu Thr Leu Gln Ala Leu Ser Ser 
225                 230                 235                 240 


Leu Tyr Ser Ala Asn Ile Thr Glu Ile Met Thr Thr Ile Arg Thr Gly 
                245                 250                 255     


Gln Ser Asn Ile Tyr Asp Val Ile Tyr Thr Glu Gln Ile Lys Gly Thr 
            260                 265                 270         


Val Ile Asp Val Asp Leu Glu Arg Tyr Met Val Thr Leu Ser Val Lys 
        275                 280                 285             


Ile Pro Ile Leu Ser Glu Val Pro Gly Val Leu Ile His Lys Ala Ser 
    290                 295                 300                 


Ser Ile Ser Tyr Asn Ile Asp Gly Glu Glu Trp Tyr Val Thr Val Pro 
305                 310                 315                 320 


Ser His Ile Leu Ser Arg Ala Ser Phe Leu Gly Gly Ala Asn Ile Ala 
                325                 330                 335     


Asp Cys Val Glu Ser Arg Leu Thr Tyr Ile Cys Pro Arg Asp Pro Ala 
            340                 345                 350         


Gln Leu Ile Pro Asp Ser Gln Gln Lys Cys Ile Leu Gly Asp Thr Thr 
        355                 360                 365             


Arg Cys Pro Val Thr Lys Val Val Asp Asn Leu Ile Pro Lys Phe Ala 
    370                 375                 380                 


Phe Val Asn Gly Gly Val Val Ala Asn Cys Ile Ala Ser Thr Cys Thr 
385                 390                 395                 400 


Cys Gly Thr Gly Arg Arg Pro Ile Ser Gln Asp Arg Ser Lys Gly Val 
                405                 410                 415     


Val Phe Leu Thr His Asp Asn Cys Gly Leu Ile Gly Val Asn Gly Ile 
            420                 425                 430         


Glu Leu Tyr Ala Asn Arg Lys Gly His Asp Ala Thr Trp Gly Val Gln 
        435                 440                 445             


Asn Leu Thr Val Gly Pro Ala Ile Ala Ile Arg Pro Val Asp Ile Ser 
    450                 455                 460                 


Leu Asn Leu Ala Ala Ala Thr Asp Phe Leu Gln Asp Ser Arg Ala Glu 
465                 470                 475                 480 


Leu Glu Lys Ala Arg Lys Ile Leu Ser Glu Val Gly Arg Trp Tyr Asn 
                485                 490                 495     


Ser Gly Ala Thr Leu Ile Thr Ile Ile Val Val Met Ile Val Val Leu 
            500                 505                 510         


Val Val Ile Ile Val Ile Val Ile Val Leu Tyr Arg Leu Arg Arg Ser 
        515                 520                 525             


Met Leu Met Ser Asn Pro Ala Gly Arg Ile Ser Arg Asp Thr Tyr Thr 
    530                 535                 540                 


Leu Glu Pro Lys Ile Arg His Met Tyr Thr Asn Gly Gly Phe Asp Ala 
545                 550                 555                 560 


Met Thr Glu Lys Arg 
                565 


<210>  144
<211>  538
<212>  PRT
<213>  Mumps virus

<400>  144

Met Lys Ala Phe Ser Val Thr Cys Leu Gly Phe Ala Val Phe Ser Ser 
1               5                   10                  15      


Ser Ile Cys Val Asn Ile Asn Ile Leu Gln Gln Ile Gly Tyr Ile Lys 
            20                  25                  30          


Gln Gln Val Arg Gln Leu Ser Tyr Tyr Ser Gln Ser Ser Ser Ser Tyr 
        35                  40                  45              


Ile Val Val Lys Leu Leu Pro Asn Ile Gln Pro Thr Asp Asn Ser Cys 
    50                  55                  60                  


Glu Phe Lys Ser Val Thr Gln Tyr Asn Lys Thr Leu Ser Asn Leu Leu 
65                  70                  75                  80  


Leu Pro Ile Ala Glu Asn Ile Asn Asn Ile Ala Ser Pro Ser Pro Gly 
                85                  90                  95      


Ser Arg Arg His Lys Arg Phe Ala Gly Ile Ala Ile Gly Ile Ala Ala 
            100                 105                 110         


Leu Gly Val Ala Thr Ala Ala Gln Val Thr Ala Ala Val Ser Leu Val 
        115                 120                 125             


Gln Ala Gln Thr Asn Ala Arg Ala Ile Ala Ala Met Lys Asn Ser Ile 
    130                 135                 140                 


Gln Ala Thr Asn Arg Ala Ile Phe Glu Val Lys Glu Gly Thr Gln Gln 
145                 150                 155                 160 


Leu Ala Ile Ala Val Gln Ala Ile Gln Asp His Ile Asn Thr Ile Met 
                165                 170                 175     


Asn Thr Gln Leu Asn Asn Met Ser Cys Gln Ile Leu Asp Asn Gln Leu 
            180                 185                 190         


Ala Thr Tyr Leu Gly Leu Tyr Leu Thr Glu Leu Thr Thr Val Phe Gln 
        195                 200                 205             


Pro Gln Leu Ile Asn Pro Ala Leu Ser Pro Ile Ser Ile Gln Ala Leu 
    210                 215                 220                 


Arg Ser Leu Leu Gly Ser Met Thr Pro Ala Val Val Gln Ala Thr Leu 
225                 230                 235                 240 


Ser Thr Ser Ile Ser Ala Ala Glu Ile Leu Ser Ala Gly Leu Met Glu 
                245                 250                 255     


Gly Gln Ile Val Ser Val Leu Leu Asp Glu Met Gln Met Ile Val Lys 
            260                 265                 270         


Ile Asn Ile Pro Thr Ile Val Thr Gln Ser Asn Ala Leu Val Ile Asp 
        275                 280                 285             


Phe Tyr Ser Ile Ser Ser Phe Ile Asn Asn Gln Glu Ser Ile Ile Gln 
    290                 295                 300                 


Leu Pro Asp Arg Ile Leu Glu Ile Gly Asn Glu Gln Trp Ser Tyr Pro 
305                 310                 315                 320 


Ala Lys Asn Cys Lys Leu Thr Arg His His Ile Phe Cys Gln Tyr Asn 
                325                 330                 335     


Glu Ala Glu Arg Leu Ser Leu Glu Ser Lys Leu Cys Leu Ala Gly Asn 
            340                 345                 350         


Ile Ser Ala Cys Val Phe Ser Pro Ile Ala Gly Ser Tyr Met Arg Arg 
        355                 360                 365             


Phe Val Ala Leu Asp Gly Thr Ile Val Ala Asn Cys Arg Ser Leu Thr 
    370                 375                 380                 


Cys Leu Cys Lys Ser Pro Ser Tyr Pro Ile Tyr Gln Pro Asp His His 
385                 390                 395                 400 


Ala Val Thr Thr Ile Asp Leu Thr Thr Cys Gln Thr Leu Ser Leu Asp 
                405                 410                 415     


Gly Leu Asp Phe Ser Ile Val Ser Leu Ser Asn Ile Thr Tyr Ala Glu 
            420                 425                 430         


Asn Leu Thr Ile Ser Leu Ser Gln Thr Ile Asn Thr Gln Pro Ile Asp 
        435                 440                 445             


Ile Ser Thr Glu Leu Ser Lys Val Asn Ala Ser Leu Gln Asn Ala Val 
    450                 455                 460                 


Lys Tyr Ile Lys Glu Ser Asn His Gln Leu Gln Ser Val Ser Val Asn 
465                 470                 475                 480 


Ser Lys Ile Gly Ala Ile Ile Val Ala Ala Leu Val Leu Ser Ile Leu 
                485                 490                 495     


Ser Ile Ile Ile Ser Leu Leu Phe Cys Cys Trp Ala Tyr Ile Ala Thr 
            500                 505                 510         


Lys Glu Ile Arg Arg Ile Asn Phe Lys Thr Asn His Ile Asn Thr Ile 
        515                 520                 525             


Ser Ser Ser Val Asp Asp Leu Ile Arg Tyr 
    530                 535             


<210>  145
<211>  508
<212>  PRT
<213>  Infectious hematopoietic necrosis virus

<400>  145

Met Asp Thr Thr Ile Thr Thr Pro Leu Ile Leu Ile Leu Ile Thr Cys 
1               5                   10                  15      


Gly Ala Asn Ser Gln Thr Val Lys Pro Asp Thr Ala Ser Glu Ser Asp 
            20                  25                  30          


Gln Pro Thr Trp Ser Asn Pro Leu Phe Thr Tyr Pro Glu Gly Cys Thr 
        35                  40                  45              


Leu Asp Lys Leu Ser Lys Val Asn Ala Ser Gln Leu Arg Cys Pro Arg 
    50                  55                  60                  


Ile Phe Asp Asp Glu Asn Arg Gly Leu Ile Ala Tyr Pro Thr Ser Ile 
65                  70                  75                  80  


Arg Ser Leu Ser Val Gly Asn Asp Leu Gly Asp Ile His Thr Gln Gly 
                85                  90                  95      


Asn His Ile His Lys Val Leu Tyr Arg Thr Ile Cys Ser Thr Gly Phe 
            100                 105                 110         


Phe Gly Gly Gln Thr Ile Glu Lys Ala Leu Val Glu Met Lys Leu Ser 
        115                 120                 125             


Thr Lys Glu Ala Gly Ala Tyr Asp Thr Thr Thr Ala Ala Ala Leu Tyr 
    130                 135                 140                 


Phe Pro Ala Pro Arg Cys Gln Trp Tyr Thr Asp Asn Val Gln Asn Asp 
145                 150                 155                 160 


Leu Ile Phe Tyr Tyr Thr Thr Gln Lys Ser Val Leu Arg Asp Pro Tyr 
                165                 170                 175     


Thr Arg Asp Phe Leu Asp Ser Asp Phe Ile Gly Gly Lys Cys Thr Lys 
            180                 185                 190         


Ser Pro Cys Gln Thr His Trp Ser Asn Val Val Trp Met Gly Asp Ala 
        195                 200                 205             


Gly Ile Pro Ala Cys Asp Ser Ser Gln Glu Ile Lys Gly His Leu Phe 
    210                 215                 220                 


Val Asp Lys Ile Ser Asn Arg Val Val Lys Ala Thr Ser Tyr Gly His 
225                 230                 235                 240 


His Pro Trp Gly Leu His Gln Ala Cys Met Ile Glu Phe Cys Gly Lys 
                245                 250                 255     


Gln Trp Ile Arg Thr Asp Leu Gly Asp Leu Ile Ser Val Glu Tyr Asn 
            260                 265                 270         


Ser Gly Ala Glu Ile Leu Ser Phe Pro Lys Cys Glu Asp Lys Thr Val 
        275                 280                 285             


Gly Met Arg Gly Asn Leu Asp Asp Phe Ala Tyr Leu Asp Asp Leu Val 
    290                 295                 300                 


Lys Ala Ser Glu Ser Arg Glu Glu Cys Leu Glu Ala His Ala Glu Ile 
305                 310                 315                 320 


Ile Ser Thr Asn Ser Val Thr Pro Tyr Leu Leu Ser Lys Phe Arg Ser 
                325                 330                 335     


Pro His Pro Gly Ile Asn Asp Val Tyr Ala Met His Lys Gly Ser Ile 
            340                 345                 350         


Tyr His Gly Met Cys Met Thr Val Ala Val Asp Glu Val Ser Lys Asp 
        355                 360                 365             


Arg Thr Thr Tyr Arg Ala His Arg Ala Thr Ser Phe Thr Lys Trp Glu 
    370                 375                 380                 


Arg Pro Phe Gly Asp Glu Trp Glu Gly Phe His Gly Leu His Gly Asn 
385                 390                 395                 400 


Asn Thr Thr Ile Ile Pro Asp Leu Glu Lys Tyr Val Ala Gln Tyr Lys 
                405                 410                 415     


Thr Ser Met Met Glu Pro Met Ser Ile Lys Ser Val Pro His Pro Ser 
            420                 425                 430         


Ile Leu Ala Leu Tyr Asn Glu Thr Asp Val Ser Gly Ile Ser Ile Arg 
        435                 440                 445             


Lys Leu Asp Ser Phe Asp Leu Gln Ser Leu His Trp Ser Phe Trp Pro 
    450                 455                 460                 


Thr Ile Ser Ala Leu Gly Gly Ile Pro Phe Ala Leu Leu Leu Ala Val 
465                 470                 475                 480 


Ala Ala Cys Cys Cys Trp Ser Gly Arg Pro Pro Thr Pro Ser Ala Ser 
                485                 490                 495     


Gln Ser Ile Pro Met Tyr His Leu Ala Asn Arg Ser 
            500                 505             


<210>  146
<211>  561
<212>  PRT
<213>  Drosophila melanogaster sigma virus

<400>  146

Met Ala His Tyr Glu Leu His Val Leu Phe Val His Ser Trp Met Leu 
1               5                   10                  15      


Ala Leu Ile Leu Ile Thr Thr Leu Val Trp Leu Ala Ala Ser Gln Lys 
            20                  25                  30          


Ala Phe Thr Pro Asp Leu Val Phe Pro Glu Met Asn Arg Asn Ser Ser 
        35                  40                  45              


Trp Ser Val Ala Asn Tyr Gly Glu Ile Leu Cys Pro Thr Ser Phe Gln 
    50                  55                  60                  


Ser Tyr Asp Pro Lys Lys His Gln Ile Leu Thr Arg Val Leu Val Glu 
65                  70                  75                  80  


Arg Pro Ser Leu Asn Thr Asp Thr Lys Val Glu Gly Tyr Thr Cys His 
                85                  90                  95      


Lys Val Lys Tyr Glu Thr Ile Cys Asp Met Pro Trp Tyr Phe Ser Pro 
            100                 105                 110         


Thr Ile Ser His Ser Ile Ser Pro Leu Arg Val Lys Glu Ser Glu Cys 
        115                 120                 125             


Lys Asp Ala Ile Ala Glu His Gln Leu Gly Thr His Val Pro Leu Ser 
    130                 135                 140                 


Phe Pro Pro Glu Asp Cys Ser Trp Asn Ser Val Asn Thr Lys Glu Tyr 
145                 150                 155                 160 


Glu Asp Ile Ile Val Lys Glu His Pro Val Met Leu Asp Pro Tyr Thr 
                165                 170                 175     


Asn Asn Tyr Val Asp Ala Ile Phe Pro Gly Gly Ile Ser Ser Pro Gly 
            180                 185                 190         


Met Gly Gly Thr Ile His Asp Asp Met Met Trp Val Ser Lys Asp Leu 
        195                 200                 205             


Ala Val Ser Pro Glu Cys Ser Gly Trp Gln Arg Ser Met Gly Leu Ile 
    210                 215                 220                 


Tyr Ser Ser Arg Leu Tyr Gly Glu Arg Glu Pro Met Leu Glu Val Gly 
225                 230                 235                 240 


Ser Ile His Ile Glu Gly His Arg Asp Lys Asn Leu Thr Leu Ala Cys 
                245                 250                 255     


Arg Ile Ser Phe Cys Gly Glu Ile Gly Val Arg Phe His Asp Gly Glu 
            260                 265                 270         


Trp Met Lys Val Ser Val Asn Leu Asp His Pro Asn Ser Val Thr Phe 
        275                 280                 285             


Gln Val Thr Asp Phe Pro Pro Cys Pro Pro Gly Thr Thr Ile Gln Thr 
    290                 295                 300                 


Ala Val Val Glu Asn Ile Asn Pro Glu Ile Gln Glu Leu Thr Val Asn 
305                 310                 315                 320 


Met Met Tyr Arg Leu Lys Cys Gln Glu Thr Ile Ser Lys Met Val Ser 
                325                 330                 335     


Gly Leu Pro Thr Ser Ala Leu Asp Leu Ser Tyr Leu Ile Gln Val Gln 
            340                 345                 350         


Glu Gly Pro Gly Ile Val Tyr Lys Arg Glu Lys Gly Ile Leu Tyr Gln 
        355                 360                 365             


Ser Val Gly Met Tyr Gln Tyr Ile Asp Thr Val Thr Leu Asn Lys Glu 
    370                 375                 380                 


Glu Asn Gln Leu Gly Glu Asn Ser Arg Gly Gln Lys Val Phe Trp Thr 
385                 390                 395                 400 


Glu Trp Ser Asp Ser Pro Thr Arg Pro Gly Leu Gln Glu Gly Ile Asn 
                405                 410                 415     


Gly Ile Val Lys Tyr Glu Gly Gln Val Arg Val Pro Leu Gly Met Ser 
            420                 425                 430         


Leu Arg Leu Glu Ala Ala Thr Glu Leu Met Trp Gly His Pro Val His 
        435                 440                 445             


Thr Val Ser His Pro Ile Leu His Val Ile Ser Asn His Thr Glu Gln 
    450                 455                 460                 


Ser Val Thr Thr Trp Asn Arg Gly Val Asn Ser Thr Asn Leu Ile Gly 
465                 470                 475                 480 


Leu Ala Thr Arg Ser Ile Ser Gly Phe Tyr Asp Asn Leu Lys Leu Tyr 
                485                 490                 495     


Leu Ile Leu Ala Leu Ile Phe Val Ser Leu Ile Ala Leu Val Val Leu 
            500                 505                 510         


Asp Val Ile Pro Phe Lys Tyr Ile Leu Phe Val Leu Cys Pro Pro Leu 
        515                 520                 525             


Leu Leu Cys Arg Phe Ile Lys Cys Ser Arg Arg Lys Pro Glu Thr Arg 
    530                 535                 540                 


Asp Arg Tyr His Val Glu Tyr Asn Arg Pro Gly Gln Val Ser Ser Ala 
545                 550                 555                 560 


Phe 
    


<210>  147
<211>  508
<212>  PRT
<213>  Hirame rhabdovirus

<400>  147

Met Asp Pro Arg Ile Met Tyr Tyr Thr Val Leu Leu Thr Thr Ala Ala 
1               5                   10                  15      


Arg Val Tyr Gly Gln Thr Ile Lys Pro Gly Val Asp Ser Val Ser Asp 
            20                  25                  30          


Gln Pro Thr Trp Ala Asn Pro Leu Phe Thr Tyr Pro Val Asp Cys Pro 
        35                  40                  45              


Ala Ala Lys Leu Ser Lys Val Ser Pro Ser Gln Leu Arg Cys Pro Arg 
    50                  55                  60                  


Ile Phe Asp Asp Glu Asn Arg Gly Leu Val Ala Tyr Pro Ala Val Ile 
65                  70                  75                  80  


Arg Ser Leu Ser Val Gly Asn Asn Leu Gly Asp Ile His Thr Gln Gly 
                85                  90                  95      


Glu Tyr Val His Lys Val Leu Tyr Arg Thr Thr Cys Ser Thr Gly Phe 
            100                 105                 110         


Phe Gly Gly Gln Thr Ile Glu Lys Ala Leu Val Glu Met Lys Leu Ala 
        115                 120                 125             


Pro Arg Glu Val Gly Val Tyr Asp Thr Thr Thr Ala Ser Ala Leu Tyr 
    130                 135                 140                 


Phe Pro Ala Pro Arg Cys Gln Trp Tyr Thr Asp Asn Val His Asn Asp 
145                 150                 155                 160 


Leu Thr Phe Tyr Tyr Thr Thr Ala Lys Ser Val Leu Arg Asp Pro Tyr 
                165                 170                 175     


Thr Leu Gly Phe Leu Asp Ser Asp Phe Ile Glu Gly Lys Cys Ser Lys 
            180                 185                 190         


Ser Pro Cys Gln Thr His Trp Ser Asn Val Val Trp Lys Gly Asp Ser 
        195                 200                 205             


Gly Val Ala Ala Cys Asp Thr Gly Ser Glu Ile Lys Gly His Ile Phe 
    210                 215                 220                 


Val Asp Lys Thr Ser His His Val Val Lys Ala Thr Ser Tyr Gly His 
225                 230                 235                 240 


His Pro Trp Gly Leu His Arg Ala Cys Met Ile Thr Phe Cys Gly Lys 
                245                 250                 255     


Pro Trp Ile Arg Thr Asp Leu Gly Asp Leu Ile Ala Ile Glu Tyr Asn 
            260                 265                 270         


Gly Gly Ala Thr Leu Leu Ala Phe Pro Ala Cys Lys Asp Thr Thr Val 
        275                 280                 285             


Gly Met Arg Gly Ser Leu Asp Asp Phe Ala Tyr Leu Asp Asp Leu Val 
    290                 295                 300                 


Lys Ser Ser Glu Ser Arg Glu Glu Cys Leu Glu Ala His Ala Glu Ile 
305                 310                 315                 320 


Ile Ala Thr Asn Ser Val Thr Pro Tyr Leu Leu Ser Lys Phe Arg Ser 
                325                 330                 335     


Pro His Pro Gly Ile Asn Asp Val Tyr Ala Met His Asp Gly Ser Ile 
            340                 345                 350         


Tyr His Gly Lys Cys Met Thr Val Ala Ile Asp Glu Val Ser Lys Asp 
        355                 360                 365             


Arg Arg Thr Tyr Arg Ala His Gln Thr Ser Ala Phe Val Ala Trp Gly 
    370                 375                 380                 


His Pro Phe Gly Asp Glu Trp Gly Gly Phe His Gly Leu His Gly Asn 
385                 390                 395                 400 


Asp Thr Pro Val Ile Pro Asp Leu Glu Lys Tyr Val Ala Gln Tyr Lys 
                405                 410                 415     


Val Ser Met Met Asp Lys Met Asp Ile Arg Pro Val Pro His Pro Ser 
            420                 425                 430         


Val Gln Ile Leu Tyr Asn Asp Thr Asp Thr Ala Asp Ile Thr Ile Arg 
        435                 440                 445             


Lys Ile Asp Ser Phe Asp Leu Gln Ser Leu Asn Trp Ser Phe Trp Pro 
    450                 455                 460                 


Ser Leu Ser Ala Leu Gly Gly Val Pro Ile Leu Leu Ala Leu Val Phe 
465                 470                 475                 480 


Phe Leu Tyr Cys Cys Met Asn Arg Arg Pro Ser Met Pro Ala Ala Pro 
                485                 490                 495     


Gln Glu Ile Pro Met Tyr His Leu Ala Ser Arg Gly 
            500                 505             


<210>  148
<211>  632
<212>  PRT
<213>  Sonchus yellow net virus

<400>  148

Met Ser His Ile Met Asn Leu Leu Val Ile Ser Phe Val Leu Ala Gly 
1               5                   10                  15      


Ser Ser Trp Ser Leu Leu Gly Tyr Gln Asp Asp Phe Ser Ser Lys Arg 
            20                  25                  30          


Ser Gly Ala Leu Ala Ser Asn Pro Thr Tyr Asn Leu Pro Gln Asp Lys 
        35                  40                  45              


Gly Tyr Gly Arg Asp Met Tyr Gln Pro Tyr Tyr Ile Cys Glu Pro Asp 
    50                  55                  60                  


Asn Asp Gly Ser Ala Leu Thr Leu Pro Ser Trp His Tyr Ser Cys Lys 
65                  70                  75                  80  


Glu Ser Cys Met Gly Asn His Leu Lys Arg Val Val Asn Ile Thr Gly 
                85                  90                  95      


Ala Arg Trp Asn Tyr Val Gly Ile Ser Ile Pro Val Phe Lys Ile Val 
            100                 105                 110         


Thr Asn Glu Val Cys Tyr Thr Ser His Glu Asn Val Trp Gly Tyr Cys 
        115                 120                 125             


Ser Gln Tyr Gln Ile Ser Arg Pro Val Ala Thr Gln Lys Ser Asp Val 
    130                 135                 140                 


Ser Cys Ile Thr Ser Ser Met Trp Asp Asn Asp Lys Ser Pro Ile Gly 
145                 150                 155                 160 


Ser Leu Tyr Asn Ile Val Asn Ser Asn Glu Ala Glu Cys Asp Tyr Phe 
                165                 170                 175     


Ser Asp Ile Thr Asp Cys Asn Arg Asp Tyr Gln Ile Phe Lys Arg Glu 
            180                 185                 190         


Gly Lys Leu Ile Lys Arg Ser Asp Asp Ser Pro Leu Glu Leu Ser Ile 
        195                 200                 205             


Val Thr Asp Gly Ile Arg Thr Asp Pro Ala Ser Glu Tyr Leu Ser Leu 
    210                 215                 220                 


Asp Asp Val Ser Trp Phe Trp Lys Leu Pro Asn Asn Asp Met Ser Pro 
225                 230                 235                 240 


Pro Cys Gly Trp Glu Lys Thr Gln Lys Leu Ser Cys Ser Tyr Thr Asp 
                245                 250                 255     


Thr Thr Asp Val Ile Lys Cys Asn Ser Ile Gly Tyr Thr Tyr Asn Ile 
            260                 265                 270         


Gln Gly Ile Ser Lys Lys Ser Thr Cys Ala Gly Asn Ile Tyr Asp Thr 
        275                 280                 285             


Asp Gly Pro Phe Pro Phe Phe Tyr Asp Ala Glu Glu Ala Leu Met Ser 
    290                 295                 300                 


Thr Asp Asp Ala Cys Gly Lys Ala Lys Gln Gly Lys Pro Asp Ala Asp 
305                 310                 315                 320 


Ile Ala Phe Ile Glu Gly Val Asn Arg Ala Phe Glu Asp Leu Glu Leu 
                325                 330                 335     


Thr Tyr Cys Ser Ala Thr Cys Asp Leu Phe Ala Arg Gln Gly Thr Pro 
            340                 345                 350         


Asn Glu Asp His Val Leu Asp Thr Pro Ile Gly Thr Trp Arg Tyr Val 
        355                 360                 365             


Met Arg Asp Asn Leu Asp Pro Ala Leu Val Pro Cys Leu Pro Thr Ser 
    370                 375                 380                 


Asn Trp Thr Ile Ser Asp Pro Thr Thr Ile Cys His Gly Lys Asp His 
385                 390                 395                 400 


Ile Leu Val Val Asp Thr Ala Thr Gly His Ser Gly Ser Trp Asp Thr 
                405                 410                 415     


Lys Lys Asp Tyr Ile Ile Thr Gly Glu Val Cys Asn Thr Asn Asn Asp 
            420                 425                 430         


Glu Met Gly Asp Asp Tyr Asp Gly Met Arg Asp Lys Ile Leu Arg Gly 
        435                 440                 445             


Glu Thr Ile Glu Ile Lys Phe Trp Thr Gly Asp Ile Ile Arg Met Ala 
    450                 455                 460                 


Pro Pro Tyr Asp Asn Pro Glu Trp Ile Lys Gly Ser Val Leu Phe Arg 
465                 470                 475                 480 


Gln Asn Pro Gly Trp Phe Ser Ser Val Glu Leu Asn Lys Asp Met Ile 
                485                 490                 495     


His Thr Arg Asp Asn Ile Thr Asp Leu Leu Thr Val Met Val Gln Asn 
            500                 505                 510         


Ala Thr Ala Glu Val Met Tyr Lys Arg Leu Asp Pro Lys Thr Met Lys 
        515                 520                 525             


His Ile Leu Phe Ala Glu Ile Val Asp Gly Val Gly Asn Val Ser Gly 
    530                 535                 540                 


Lys Ile Ser Gly Phe Leu Thr Gly Leu Phe Gly Gly Phe Thr Lys Ala 
545                 550                 555                 560 


Val Ile Ile Val Ala Ser Leu Ala Ile Cys Tyr Ile Val Leu Ser Val 
                565                 570                 575     


Leu Trp Lys Val Arg Leu Val Ala Ser Ile Phe Asn Ser Ala Lys Lys 
            580                 585                 590         


Lys Arg Val Arg Ile Ser Asp Ile Leu Asp Glu Glu Pro His Arg Ile 
        595                 600                 605             


Gln Gln Ser Arg Pro Thr Leu Ser Arg Lys Lys Lys Thr Arg Glu Ser 
    610                 615                 620                 


Ile Gln Met Leu Leu Asn Asp Ile 
625                 630         


<210>  149
<211>  524
<212>  PRT
<213>  European bat lyssavirus 1

<400>  149

Met Leu Leu Ser Thr Ala Ile Phe Ala Phe Phe Leu Asn Cys Ala Pro 
1               5                   10                  15      


Cys Leu Ala Lys Phe Pro Ile Tyr Thr Ile Pro Asp Lys Ile Gly Pro 
            20                  25                  30          


Trp Ser Pro Ile Asp Ile Asn His Leu Ser Cys Pro Asn Asn Leu Ile 
        35                  40                  45              


Val Glu Asp Glu Gly Cys Thr Thr Leu Thr Pro Phe Ser Tyr Met Glu 
    50                  55                  60                  


Leu Lys Val Gly Tyr Ile Thr Thr Ile Lys Ile Glu Gly Phe Thr Cys 
65                  70                  75                  80  


Thr Gly Val Ile Thr Glu Ala Glu Thr Tyr Thr Asn Phe Val Gly Tyr 
                85                  90                  95      


Val Thr Thr Thr Phe Lys Arg Lys His Phe Arg Pro Thr Val Ser Ala 
            100                 105                 110         


Cys Arg Asp Ala Tyr Asn Trp Lys Ile Thr Gly Asp Pro Arg Tyr Glu 
        115                 120                 125             


Glu Ser Leu His Asn Pro Tyr Pro Asp Ser His Trp Leu Arg Thr Val 
    130                 135                 140                 


Lys Thr Thr Lys Glu Ser Leu Leu Ile Ile Ser Pro Ser Val Val Asp 
145                 150                 155                 160 


Met Asp Ala Tyr Asp Lys Asn Leu Tyr Ser Lys Met Phe Pro Asn Gly 
                165                 170                 175     


Lys Cys Leu Ala Ser Pro Pro Ser Ala Ile Cys Cys Pro Thr Asn His 
            180                 185                 190         


Asp Tyr Thr Ile Trp Ile Pro Glu Asn Pro Lys Pro Gly Leu Ser Cys 
        195                 200                 205             


Asp Ile Phe Thr Thr Ser Lys Gly Lys Lys Ala Thr Lys Asp Gly Arg 
    210                 215                 220                 


Leu Cys Gly Phe Val Asp Glu Arg Gly Leu Tyr Lys Ser Leu Lys Gly 
225                 230                 235                 240 


Ala Cys Lys Gln Arg Leu Cys Gly Val Pro Gly Met Arg Leu Met Asp 
                245                 250                 255     


Gly Ser Trp Val Ser Leu Gln Lys Thr Glu Ala Pro Glu Trp Cys Ser 
            260                 265                 270         


Pro Asp Gln Leu Val Asn Val His Asp Phe His Thr Asp Glu Ile Glu 
        275                 280                 285             


His Leu Val Val Glu Glu Leu Val Lys Lys Arg Glu Glu Cys Leu Asp 
    290                 295                 300                 


Ala Leu Glu Thr Ile Ile Thr Thr Lys Ser Ile Ser Phe Arg Arg Leu 
305                 310                 315                 320 


Ser His Phe Arg Lys Leu Val Pro Gly Phe Gly Lys Ala Tyr Thr Leu 
                325                 330                 335     


Ile Asn Lys Thr Leu Met Glu Ala Asp Ala His Tyr Lys Ser Val Arg 
            340                 345                 350         


Glu Trp Lys Glu Val Ile Pro Ser Lys Gly Cys Leu Met Ala Gly Gly 
        355                 360                 365             


Arg Cys His Pro His Tyr Ser Gly Ile Phe Phe Asn Gly Ile Ile Leu 
    370                 375                 380                 


Ser Pro Gly Gly Asp Val Leu Ile Pro Glu Met Gln Ser Ala Leu Leu 
385                 390                 395                 400 


Gln Gln His Ile Glu Leu Leu Glu Ser Ser Met Ile Pro Leu Arg His 
                405                 410                 415     


Pro Leu Ala Asp Pro Ser Thr Val Phe Lys Arg Asp Asp Glu Ala Glu 
            420                 425                 430         


Asp Phe Val Glu Val His Leu Pro Asp Thr Gln Lys Leu Ile Ser Gly 
        435                 440                 445             


Ile Asp Leu Gly Phe Pro Glu Trp Lys Arg Tyr Phe Leu Ile Gly Ile 
    450                 455                 460                 


Ser Val Leu Ala Leu Leu Ala Leu Ala Ile Ile Thr Ala Ala Cys Cys 
465                 470                 475                 480 


Lys Arg Phe Lys Arg Arg Arg Arg Pro Lys Pro Asn Pro Ile Glu Leu 
                485                 490                 495     


Ile Arg Lys Val Ser Val Thr Ser Gln Ser Gly Arg Ala Ile Pro Ser 
            500                 505                 510         


Trp Glu Ser Tyr Lys Val Gly Ala Thr Gly Glu Ser 
        515                 520                 


<210>  150
<211>  522
<212>  PRT
<213>  Lagos bat virus

<400>  150

Met Ser Gln Leu Asn Leu Ile Pro Phe Phe Cys Val Ile Ile Val Leu 
1               5                   10                  15      


Ser Val Glu Asp Phe Pro Leu Tyr Thr Ile Pro Glu Lys Ile Gly Pro 
            20                  25                  30          


Trp Thr Pro Ile Asp Leu Ile His Leu Ser Cys Pro Asn Asn Leu Gln 
        35                  40                  45              


Ser Glu Asp Glu Gly Cys Gly Thr Ser Ser Val Phe Ser Tyr Val Glu 
    50                  55                  60                  


Leu Lys Thr Gly Tyr Leu Thr His Gln Lys Val Ser Gly Phe Thr Cys 
65                  70                  75                  80  


Thr Gly Val Val Asn Glu Ala Val Thr Tyr Thr Asn Phe Val Gly Tyr 
                85                  90                  95      


Val Thr Thr Thr Phe Lys Arg Lys His Phe Lys Pro Thr Ala Leu Ala 
            100                 105                 110         


Cys Arg Asp Ala Tyr His Trp Lys Ile Ser Gly Asp Pro Arg Tyr Glu 
        115                 120                 125             


Glu Ser Leu His Thr Pro Tyr Pro Asp Asn Ser Trp Leu Arg Thr Val 
    130                 135                 140                 


Thr Thr Thr Lys Glu Ser Leu Val Ile Ile Ser Pro Ser Ile Val Glu 
145                 150                 155                 160 


Met Asp Val Tyr Ser Arg Thr Leu His Ser Pro Met Phe Pro Thr Gly 
                165                 170                 175     


Thr Cys Ser Arg Phe Tyr Pro Ser Ser Pro Ser Cys Ala Thr Asn His 
            180                 185                 190         


Asp Tyr Thr Leu Trp Leu Pro Asp Asp Pro Asn Leu Ser Leu Ala Cys 
        195                 200                 205             


Asp Ile Phe Val Thr Ser Thr Gly Lys Lys Ser Met Asn Gly Ser Arg 
    210                 215                 220                 


Met Cys Gly Phe Thr Asp Glu Arg Gly Tyr Tyr Arg Thr Ile Lys Gly 
225                 230                 235                 240 


Ala Cys Lys Leu Thr Leu Cys Gly Lys Pro Gly Leu Arg Leu Phe Asp 
                245                 250                 255     


Gly Thr Trp Ile Ser Phe Pro Arg Pro Glu Val Thr Thr Arg Cys Leu 
            260                 265                 270         


Pro Asn Gln Leu Val Asn Ile His Asn Asn Arg Ile Asp Glu Val Glu 
        275                 280                 285             


His Leu Ile Val Glu Asp Leu Ile Arg Lys Arg Glu Glu Cys Leu Asp 
    290                 295                 300                 


Thr Leu Glu Thr Val Leu Met Ser Lys Ser Ile Ser Phe Arg Arg Leu 
305                 310                 315                 320 


Ser His Phe Arg Lys Leu Val Pro Gly Tyr Gly Lys Ala Tyr Thr Ile 
                325                 330                 335     


Leu Asn Gly Ser Leu Met Glu Thr Asn Val His Tyr Leu Lys Val Asp 
            340                 345                 350         


Asn Trp Ser Glu Ile Leu Pro Ser Lys Gly Cys Leu Lys Ile Asn Asn 
        355                 360                 365             


Gln Cys Val Ala His Tyr Lys Gly Val Phe Phe Asn Gly Ile Ile Lys 
    370                 375                 380                 


Gly Pro Asp Gly His Ile Leu Ile Pro Glu Met Gln Ser Ser Leu Leu 
385                 390                 395                 400 


Lys Gln His Met Asp Leu Leu Lys Ala Ala Val Phe Pro Leu Lys His 
                405                 410                 415     


Pro Leu Ile Glu Pro Gly Ser Leu Phe Asn Lys Asp Gly Asp Ala Asp 
            420                 425                 430         


Glu Phe Val Asp Val His Met Pro Asp Val His Lys Leu Val Ser Asp 
        435                 440                 445             


Val Asp Leu Gly Leu Pro Asp Trp Ser Leu Tyr Ala Leu Ile Gly Ala 
    450                 455                 460                 


Thr Ile Ile Ala Phe Phe Ile Leu Ile Cys Leu Ile Arg Ile Cys Cys 
465                 470                 475                 480 


Lys Lys Gly Gly Arg Arg Asn Ser Pro Thr Asn Arg Pro Asp Leu Pro 
                485                 490                 495     


Ile Gly Leu Ser Thr Thr Pro Gln Pro Lys Ser Lys Val Ile Ser Ser 
            500                 505                 510         


Trp Glu Ser Tyr Lys Gly Thr Ser Asn Val 
        515                 520         


<210>  151
<211>  533
<212>  PRT
<213>  Duvenhage virus

<400>  151

Met Pro Leu Asn Ala Val Ile Phe Thr Leu Leu Leu Arg Cys Ser Ile 
1               5                   10                  15      


Cys Leu Gly Lys Phe Pro Phe Tyr Thr Ile Pro Asp Lys Leu Gly Pro 
            20                  25                  30          


Trp Ser Pro Ile Asp Ile His His Leu Ser Cys Pro Asn Asn Leu Val 
        35                  40                  45              


Val Glu Asp Glu Gly Cys Thr Thr Leu Thr Pro Phe Ser Tyr Met Glu 
    50                  55                  60                  


Leu Lys Val Gly Tyr Ile Thr Ser Ile Lys Val Ser Gly Phe Thr Cys 
65                  70                  75                  80  


Thr Gly Val Val Thr Glu Ala Glu Thr Tyr Thr Asn Phe Val Gly Tyr 
                85                  90                  95      


Val Thr Thr Thr Phe Arg Arg Arg His Phe Arg Pro Ser Val Asn Ser 
            100                 105                 110         


Cys Arg Asp Ala Tyr Asn Trp Lys Ile Ala Gly Asp Pro Arg Tyr Glu 
        115                 120                 125             


Glu Ser Leu His Asn Pro Tyr Pro Asp Ser His Trp Leu Arg Thr Val 
    130                 135                 140                 


Lys Thr Thr Lys Glu Ser Leu Leu Ile Ile Ser Pro Ser Val Ala Asp 
145                 150                 155                 160 


Met Asp Ala Tyr Asp Lys Lys Leu Tyr Ser Lys Ile Val Ser Asn Gly 
                165                 170                 175     


Arg Cys Ser Glu Ile Ser Pro Gly Ser Pro Phe Cys Pro Thr Asn His 
            180                 185                 190         


Glu Tyr Thr Ile Trp Met Pro Glu Ser Ser Asn Pro Gly Ile Ser Cys 
        195                 200                 205             


Asp Ile Phe Thr Arg Ser Met Gly Lys Lys Ala Thr Lys Asp Gly Gln 
    210                 215                 220                 


Leu Cys Gly Phe Val Asp Glu Arg Gly Leu Tyr Lys Ser Leu Lys Gly 
225                 230                 235                 240 


Ala Cys Arg Leu Arg Leu Cys Gly Ile Ser Gly Leu Arg Leu Met Asp 
                245                 250                 255     


Gly Ser Trp Val Ser Leu Pro Gln Val Asn Asn Ser Glu Trp Cys Ser 
            260                 265                 270         


Pro Asp Gln Leu Val Asn Ile His Asp Phe His Ser Asp Glu Ile Glu 
        275                 280                 285             


His Leu Val Ala Asp Glu Leu Val Lys Lys Arg Glu Asp Cys Leu Asp 
    290                 295                 300                 


Ala Leu Glu Thr Ile Leu Phe Thr Lys Ser Ile Ser Phe Arg Arg Leu 
305                 310                 315                 320 


Ser His Leu Arg Lys Leu Val Pro Gly Phe Gly Lys Ala Tyr Thr Ile 
                325                 330                 335     


Ile Asn Arg Thr Leu Met Glu Ala Glu Ala His Tyr Lys Ser Val Arg 
            340                 345                 350         


Glu Trp Lys Glu Ile Ile Pro Ser Lys Gly Cys Leu Lys Ala Gly Gly 
        355                 360                 365             


Arg Cys Tyr Pro His His Asn Gly Ile Phe Phe Asn Gly Ile Ile Leu 
    370                 375                 380                 


Gly Pro Gly Gly Glu Ile Leu Ile Pro Glu Met Gln Ser Ala Leu Leu 
385                 390                 395                 400 


Gln Gln His Ile Glu Leu Leu Glu Ser Ser Val Val Pro Leu Lys His 
                405                 410                 415     


Pro Leu Ala Asp Pro Ser Thr Val Phe Lys Asn Asp Asp Glu Ala Glu 
            420                 425                 430         


Ser Phe Val Asp Val His Leu Pro Asp Thr Asn Gln Lys Ile Ser Gly 
        435                 440                 445             


Ile Asp Leu Gly Leu Pro Glu Trp Lys Arg Tyr Phe Leu Ile Gly Val 
    450                 455                 460                 


Ser Ala Val Ala Leu Leu Ala Leu Ser Ile Ile Ile Ala Val Cys Cys 
465                 470                 475                 480 


Lys Arg Phe Arg Lys Arg Lys Lys Ser Lys Pro Gly Pro Val Glu Leu 
                485                 490                 495     


Thr Arg Lys Val Ser Val Ile Ser Lys Gly Asn Gly Pro Val Pro Ser 
            500                 505                 510         


Trp Glu Ser Tyr Lys Glu Gly Thr Thr Gly Asp Val Arg Asn Thr Thr 
        515                 520                 525             


Pro Ser Thr Arg Glu 
    530             


<210>  152
<211>  525
<212>  PRT
<213>  West Caucasian bat virus

<400>  152

Met Ala Ser Tyr Phe Ala Leu Val Leu Asn Gly Ile Ser Met Val Phe 
1               5                   10                  15      


Ser Gln Gly Leu Phe Pro Leu Tyr Thr Ile Pro Asp His Leu Gly Pro 
            20                  25                  30          


Trp Thr Pro Ile Asp Leu Ser His Leu His Cys Pro Asn Asn Leu Tyr 
        35                  40                  45              


Thr Asp Ala Ser Tyr Cys Thr Thr Glu Gln Ser Ile Thr Tyr Thr Glu 
    50                  55                  60                  


Leu Lys Val Gly Ser Ser Val Ser Gln Lys Ile Pro Gly Phe Thr Cys 
65                  70                  75                  80  


Thr Gly Val Arg Thr Glu Ser Val Thr Tyr Thr Asn Phe Val Gly Tyr 
                85                  90                  95      


Val Thr Thr Thr Phe Lys Lys Lys His Phe Pro Pro Lys Ser Arg Asp 
            100                 105                 110         


Cys Arg Glu Ala Tyr Glu Arg Lys Lys Ala Gly Asp Pro Arg Tyr Glu 
        115                 120                 125             


Glu Ser Leu Ala His Pro Tyr Pro Asp Asn Ser Trp Leu Arg Thr Val 
    130                 135                 140                 


Thr Thr Thr Lys Asp Ser Trp Val Ile Ile Glu Pro Ser Val Val Glu 
145                 150                 155                 160 


Leu Asp Ile Tyr Thr Ser Ala Leu Tyr Ser Pro Leu Phe Lys Asp Gly 
                165                 170                 175     


Thr Cys Ser Lys Ser Arg Thr Tyr Ser Pro Tyr Cys Pro Thr Asn His 
            180                 185                 190         


Asp Phe Thr Ile Trp Met Pro Glu Ser Glu Asn Ile Arg Ser Ala Cys 
        195                 200                 205             


Asn Leu Phe Ser Thr Ser Arg Gly Lys Leu Val Arg Asn Arg Thr Ser 
    210                 215                 220                 


Thr Cys Gly Ile Ile Asp Glu Arg Gly Leu Phe Arg Ser Val Lys Gly 
225                 230                 235                 240 


Ala Cys Lys Ile Ser Ile Cys Gly Arg Gln Gly Ile Arg Leu Val Asp 
                245                 250                 255     


Gly Thr Trp Met Ser Phe Arg Tyr Ser Glu Tyr Leu Pro Val Cys Ser 
            260                 265                 270         


Pro Ser Gln Leu Ile Asn Thr His Asp Ile Lys Val Asp Glu Leu Glu 
        275                 280                 285             


Asn Ala Ile Val Leu Asp Leu Ile Arg Arg Arg Glu Glu Cys Leu Asp 
    290                 295                 300                 


Thr Leu Glu Thr Ile Leu Met Ser Gly Ser Val Ser His Arg Arg Leu 
305                 310                 315                 320 


Ser His Phe Arg Lys Leu Val Pro Gly Ser Gly Lys Ala Tyr Ser Tyr 
                325                 330                 335     


Ile Asn Gly Thr Leu Met Glu Ser Asp Ala His Tyr Ile Lys Val Glu 
            340                 345                 350         


Asn Trp Ser Glu Val Ile Pro His Lys Gly Cys Leu Met Val Gly Gly 
        355                 360                 365             


Lys Cys Tyr Glu Pro Val Asn Asp Val Tyr Phe Asn Gly Ile Ile Arg 
    370                 375                 380                 


Asp Ser Asn Asn Gln Ile Leu Ile Pro Glu Met Gln Ser Ser Leu Leu 
385                 390                 395                 400 


Arg Glu His Val Asp Leu Leu Lys Ala Asn Ile Val Pro Phe Arg His 
                405                 410                 415     


Pro Met Leu Leu Arg Ser Phe Thr Ser Asp Thr Glu Glu Asp Ile Val 
            420                 425                 430         


Glu Phe Val Asn Pro His Leu Gln Asp Thr Gln Lys Leu Val Ser Asp 
        435                 440                 445             


Met Asp Leu Gly Leu Ser Asp Trp Lys Arg Tyr Leu Leu Ile Gly Ser 
    450                 455                 460                 


Leu Ala Val Gly Gly Val Val Ala Ile Leu Phe Ile Gly Thr Cys Cys 
465                 470                 475                 480 


Leu Arg Cys Arg Ala Gly Arg Asn Arg Arg Thr Ile Arg Ser Asn His 
                485                 490                 495     


Arg Ser Leu Ser His Asp Val Val Phe His Lys Asp Lys Asp Lys Val 
            500                 505                 510         


Ile Thr Ser Trp Glu Ser Tyr Lys Gly Gln Thr Ala Gln 
        515                 520                 525 


<210>  153
<211>  524
<212>  PRT
<213>  European bat lyssavirus 2

<400>  153

Met Pro Phe Gln Ala Val Leu Ser Ala Leu Leu Ser Ala Leu Thr Leu 
1               5                   10                  15      


Cys Val Gly Lys Phe Pro Ile Tyr Thr Ile Pro Asp Lys Leu Gly Pro 
            20                  25                  30          


Trp Ser Pro Ile Asp Ile His His Leu Ser Cys Pro Asn Asn Ile Val 
        35                  40                  45              


Val Glu Asp Glu Gly Cys Thr Thr Leu Thr Val Phe Ser Tyr Met Glu 
    50                  55                  60                  


Leu Lys Val Gly Tyr Ile Thr Thr Ile Lys Val Asn Gly Phe Thr Cys 
65                  70                  75                  80  


Thr Gly Val Val Thr Glu Ala Glu Thr Tyr Thr Asn Phe Val Gly Tyr 
                85                  90                  95      


Val Thr Thr Thr Phe Lys Arg Lys His Phe Arg Pro Ser Pro Ser Ala 
            100                 105                 110         


Cys Arg Asp Ala Tyr Ser Trp Lys Thr Ala Gly Asp Pro Arg Tyr Glu 
        115                 120                 125             


Glu Ser Leu His Asn Pro Tyr Pro Asp Ser His Trp Leu Arg Thr Val 
    130                 135                 140                 


Thr Thr Thr Lys Glu Ser Val Leu Ile Ile Ser Pro Ser Val Ala Asp 
145                 150                 155                 160 


Met Asp Ala Tyr Asp Lys Thr Leu Tyr Ser Lys Ile Phe Leu Asn Gly 
                165                 170                 175     


Lys Cys Ser Gly Val Ser Gln Val Ser Pro Phe Cys Ser Thr Asn His 
            180                 185                 190         


Asp Tyr Thr Ile Trp Met Pro Glu Asn Pro Asn Pro Gly Val Ser Cys 
        195                 200                 205             


Asp Ile Phe Thr Thr Ser Lys Gly Lys Lys Ala Thr Lys Asp Gly Lys 
    210                 215                 220                 


Leu Cys Gly Phe Val Asp Glu Arg Gly Leu Tyr Lys Ser Leu Lys Gly 
225                 230                 235                 240 


Ala Cys Lys Leu Lys Leu Cys Gly Ile Ser Gly Met Arg Leu Met Asp 
                245                 250                 255     


Gly Ser Trp Val Ser Ile Gln Asn His Asp Glu Ala Lys Trp Cys Ser 
            260                 265                 270         


Pro Asp Gln Leu Val Asn Ile His Asp Phe His Ser Asp Glu Val Glu 
        275                 280                 285             


His Leu Ile Ala Glu Glu Leu Val Lys Lys Arg Glu Glu Cys Leu Asp 
    290                 295                 300                 


Ala Leu Glu Ser Ile Met Thr Thr Lys Ser Ile Ser Phe Arg Arg Leu 
305                 310                 315                 320 


Ser His Leu Arg Lys Leu Val Pro Gly Phe Gly Lys Ala Tyr Thr Ile 
                325                 330                 335     


Ile Asn Lys Thr Leu Met Glu Ala Asp Ala His Tyr Lys Ser Ile Arg 
            340                 345                 350         


Glu Trp Thr Asp Val Ile Pro Ser Lys Gly Cys Leu Met Ala Gly Gly 
        355                 360                 365             


Arg Cys Tyr Pro His His Asn Gly Val Phe Phe Asn Gly Ile Ile Leu 
    370                 375                 380                 


Ser Pro Asp Gly His Val Leu Ile Pro Glu Met Gln Ser Ala Met Leu 
385                 390                 395                 400 


Gln Gln His Ile Glu Leu Leu Glu Ser Ser Val Ile Pro Leu Met His 
                405                 410                 415     


Pro Leu Ala Asp Pro Ser Thr Ile Phe Lys Lys Asp Asp Gly Ala Glu 
            420                 425                 430         


Asp Phe Val Glu Val His Leu Pro Asp Val Gln Lys Gln Ile Ser Gly 
        435                 440                 445             


Ile Asp Leu Gly Leu Pro Glu Trp Lys Arg Tyr Phe Leu Ile Gly Val 
    450                 455                 460                 


Ser Ala Leu Ala Phe Leu Ala Leu Met Ile Phe Ile Ala Ala Cys Cys 
465                 470                 475                 480 


Arg Arg Val Lys Arg Lys Lys Arg Ala Lys Pro Asn Pro Val Glu Leu 
                485                 490                 495     


Ile Arg Lys Val Ser Val Thr Ser Gln Ser Gly Arg Pro Ile Pro Ser 
            500                 505                 510         


Trp Glu Ser Tyr Lys Val Glu Thr Gly Gly Gln Ser 
        515                 520                 


<210>  154
<211>  524
<212>  PRT
<213>  Irkut virus

<400>  154

Met Ser Leu Leu Thr Ala Val Ile Ala Phe Leu Phe Ile Ser Thr Phe 
1               5                   10                  15      


Cys Ser Gly Lys Phe Pro Ile Tyr Thr Ile Pro Asp Lys Ile Gly Pro 
            20                  25                  30          


Trp Ser Pro Ile Asp Ile Asn His Leu Ser Cys Pro Asn Asn Leu Glu 
        35                  40                  45              


Val Glu Asp Glu Gly Cys Thr Thr Leu Thr Ala Phe Asn Tyr Met Glu 
    50                  55                  60                  


Leu Lys Val Gly Tyr Ile Thr Ser Ile Lys Val Asp Gly Phe Thr Cys 
65                  70                  75                  80  


Thr Gly Val Val Thr Glu Ala Glu Thr Tyr Thr Asn Phe Val Gly Tyr 
                85                  90                  95      


Val Thr Thr Thr Phe Lys Arg Lys His Phe Arg Pro Asn Val Ser Ala 
            100                 105                 110         


Cys Arg Ala Ala Phe Ser Trp Lys Thr Ala Gly Asp Pro Arg Tyr Glu 
        115                 120                 125             


Glu Ser Leu His Asn Pro Tyr Pro Asp Ser His Trp Leu Arg Thr Val 
    130                 135                 140                 


Thr Thr Thr Lys Glu Ser Leu Leu Ile Ile Ser Pro Ser Val Val Asp 
145                 150                 155                 160 


Met Asp Ala Tyr Asp Lys Thr Leu Tyr Ser Lys Met Phe Pro Asn Gly 
                165                 170                 175     


Lys Cys Phe Pro Pro Ile Ser Asp Ser Pro Phe Cys Ser Thr Asn His 
            180                 185                 190         


Asp Tyr Thr Leu Trp Leu Pro Glu Lys Glu Lys Leu Ser Met Ser Cys 
        195                 200                 205             


Asn Ile Phe Val Ser Ser Lys Gly Lys Lys Ala Thr Lys Asp Gly Arg 
    210                 215                 220                 


Leu Cys Gly Phe Val Asp Glu Arg Gly Leu Tyr Lys Ser Leu Lys Gly 
225                 230                 235                 240 


Ala Cys Lys Leu Lys Leu Cys Gly Met Ala Gly Met Arg Leu Met Asp 
                245                 250                 255     


Gly Ser Trp Val Ser Leu Gln Arg Ala Asp Ala Pro Glu Trp Cys Pro 
            260                 265                 270         


Pro Gly Ala Leu Val Asn Val His Asp Phe His Ser Asp Glu Ile Ala 
        275                 280                 285             


His Phe Val Val Glu Glu Leu Ile Lys Lys Arg Glu Glu Cys Leu Asp 
    290                 295                 300                 


Thr Leu Glu Thr Ile Leu Thr Thr Lys Ser Ile Ser Phe Arg Arg Leu 
305                 310                 315                 320 


Ser His Phe Arg Lys Leu Val Pro Gly Leu Gly Lys Ala Tyr Thr Leu 
                325                 330                 335     


Ile Asn Asn Thr Leu Met Glu Ala Glu Ala His Tyr Lys Ser Ile Arg 
            340                 345                 350         


Glu Trp Lys Glu Ile Ile Pro Ser Lys Gly Cys Leu Lys Ala Gly Gly 
        355                 360                 365             


Arg Cys His Pro His Tyr Asp Gly Ile Phe Phe Asn Gly Ile Ile Leu 
    370                 375                 380                 


Gly Pro Asn Gly Asp Val Leu Ile Pro Glu Met Gln Ser Ser Leu Leu 
385                 390                 395                 400 


Gln Gln His Ile Glu Leu Leu Glu Ser Ser Met Ile Pro Leu Arg His 
                405                 410                 415     


Pro Leu Ala Asp Ser Ser Ala Ile Phe Arg Ser Asp Asn Glu Ala Glu 
            420                 425                 430         


Asp Phe Val Asp Val His Leu Pro Asp Thr Gln Lys Gln Val Ser Asp 
        435                 440                 445             


Ile Asp Leu Gly Phe Pro Glu Trp Lys Arg Tyr Phe Leu Ile Gly Val 
    450                 455                 460                 


Ser Ala Ile Ala Leu Phe Ser Leu Ala Ile Ile Ile Ala Val Cys Cys 
465                 470                 475                 480 


Arg Lys Phe Lys Arg Arg Lys Arg Pro Lys Pro Gly Pro Ile Glu Leu 
                485                 490                 495     


Val Arg Lys Val Ser Val Thr Ser Gln Ser Gly Lys Val Val Pro Ser 
            500                 505                 510         


Trp Glu Ser Tyr Lys Glu Gly Ala Thr Ser Gln Pro 
        515                 520                 


<210>  155
<211>  531
<212>  PRT
<213>  Tupaia virus

<400>  155

Met Ala Pro Gln Thr Ile Ser Leu Leu Trp Ala Met Val Cys Val Ser 
1               5                   10                  15      


Val Tyr Thr Arg Ala Asn Arg Val Val Ala Pro Ile His Glu Pro Gln 
            20                  25                  30          


Asn Trp Lys Pro Ala Thr Val Asp Asp Phe Thr Cys Arg Thr Gly Phe 
        35                  40                  45              


Asn Leu Asp Phe Asp Ser Lys Phe Ile Lys Thr Lys Ala Leu Val Leu 
    50                  55                  60                  


Lys Arg Val Gly Gln Ala Lys Val Lys Gly Tyr Leu Cys Met Lys Asn 
65                  70                  75                  80  


Arg Trp Thr Thr Thr Cys Glu Thr Asn Trp Leu Tyr Ser Lys Ser Val 
                85                  90                  95      


Ser His His Ile Thr His Val Ala Val Ser Ala Glu Glu Cys Tyr Asn 
            100                 105                 110         


Lys Ile Arg Asp Asp Ala Ser Gly Asn Leu Lys Ile Glu Ser Tyr Pro 
        115                 120                 125             


Asn Pro Gln Cys Ala Trp Ser Ser Thr Val Ser Arg Glu Glu Asp Phe 
    130                 135                 140                 


Ile His Ile Ser Thr Ser Asp Val Gly Tyr Asp Met Tyr Thr Asp Thr 
145                 150                 155                 160 


Val Leu Ser Pro Ser Phe Pro Gly Gly Thr Cys Lys Leu Lys Thr Cys 
                165                 170                 175     


Cys Lys Thr Ile Tyr Pro Asn Ile Val Trp Val Pro Glu Thr Pro Ala 
            180                 185                 190         


Gln Thr Gln Val Arg Asp Ala Leu Phe Asp Glu Thr Met Val Thr Val 
        195                 200                 205             


Thr Val Glu Ala Lys Lys Val Val Lys Asp Ser Trp Val Thr Gly Ala 
    210                 215                 220                 


Thr Ile Thr Pro Ser Val Met Glu Gly Ser Cys Lys Lys Thr Leu Gly 
225                 230                 235                 240 


Ser Lys Ser Gly Ile Leu Leu Pro Asn Gly Gln Trp Phe Ser Ile Val 
                245                 250                 255     


Glu Thr Gly Gln Ile Thr Ile Gln Pro Lys Gly Ser Val Glu Glu Lys 
            260                 265                 270         


Glu Thr Trp Val Asn Leu Ile Asn Asp Leu Asn Leu Ser Asp Cys Ala 
        275                 280                 285             


Glu Thr Gln Glu Ala Lys Val Pro Thr Ala Glu Phe Thr Val Tyr Lys 
    290                 295                 300                 


Thr Glu Ser Met Val Phe Asn Ile Leu Asn Tyr His Leu Cys Leu Glu 
305                 310                 315                 320 


Thr Val Ala Lys Ala Arg Ser Gly Lys Asn Leu Thr Arg Leu Asp Leu 
                325                 330                 335     


Ala Arg Leu Ala Pro Glu Ile Pro Gly Val Ala His Val Tyr Gln Leu 
            340                 345                 350         


Thr Ser Asp Gly Val Arg Val Gly Ser Thr Arg Tyr Glu Ile Ile Ala 
        355                 360                 365             


Trp Lys Pro Thr Met Gly Leu Asp Lys Thr Leu Gly Leu Thr Ile Val 
    370                 375                 380                 


Pro Ser Gly Asn Arg Asn Ser Glu Thr Ile Lys Trp Ile Glu Trp Thr 
385                 390                 395                 400 


Arg Thr Asp Asp Gly Leu Leu Asn Gly Pro Asn Gly Ile Phe Ile Ala 
                405                 410                 415     


Asp Gly Lys Glu Ile Val His Pro Asn Leu Lys Met Val Ser Phe Glu 
            420                 425                 430         


Leu Glu Thr Tyr Leu Ile Ser Glu His Ser Thr Gln Leu Val Pro His 
        435                 440                 445             


Pro Val Ile His Ser Ile Ser Asp Glu Ile Tyr Pro Glu Asn Tyr Thr 
    450                 455                 460                 


Ile Gly Gly Lys Asn Ser Tyr Ile Lys Ile His Thr Pro Thr Ala Tyr 
465                 470                 475                 480 


Phe Trp Ser Gly Ile His Trp Ile Glu Gly Ala Val Gln Lys Leu Phe 
                485                 490                 495     


Ile Val Val Val Ala Thr Ala Leu Ile Gly Leu Phe Ile Leu Val Val 
            500                 505                 510         


Trp Leu Cys Cys Gly Cys Cys Ser Lys Ser Arg Pro Val Arg Asn Gln 
        515                 520                 525             


Lys Trp Glu 
    530     


<210>  156
<211>  524
<212>  PRT
<213>  Rabies virus

<400>  156

Met Val Pro Gln Ala Leu Leu Phe Val Pro Leu Leu Val Phe Pro Leu 
1               5                   10                  15      


Cys Phe Gly Lys Phe Pro Ile Tyr Thr Ile Leu Asp Lys Leu Gly Pro 
            20                  25                  30          


Trp Ser Pro Ile Asp Ile His His Leu Ser Cys Pro Asn Asn Leu Val 
        35                  40                  45              


Val Glu Asp Glu Gly Cys Thr Asn Leu Ser Gly Phe Ser Tyr Met Glu 
    50                  55                  60                  


Leu Lys Val Gly Tyr Ile Leu Ala Ile Lys Met Asn Gly Phe Thr Cys 
65                  70                  75                  80  


Thr Gly Val Val Thr Glu Ala Glu Thr Tyr Thr Asn Phe Val Gly Tyr 
                85                  90                  95      


Val Thr Thr Thr Phe Lys Arg Lys His Phe Arg Pro Thr Pro Asp Ala 
            100                 105                 110         


Cys Arg Ala Ala Tyr Asn Trp Lys Met Ala Gly Asp Pro Arg Tyr Glu 
        115                 120                 125             


Glu Ser Leu His Asn Pro Tyr Pro Asp Tyr Arg Trp Leu Arg Thr Val 
    130                 135                 140                 


Lys Thr Thr Lys Glu Ser Leu Val Ile Ile Ser Pro Ser Val Ala Asp 
145                 150                 155                 160 


Leu Asp Pro Tyr Asp Arg Ser Leu His Ser Arg Val Phe Pro Ser Gly 
                165                 170                 175     


Lys Cys Ser Gly Val Ala Val Ser Ser Thr Tyr Cys Ser Thr Asn His 
            180                 185                 190         


Asp Tyr Thr Ile Trp Met Pro Glu Asn Pro Arg Leu Gly Met Ser Cys 
        195                 200                 205             


Asp Ile Phe Thr Asn Ser Arg Gly Lys Arg Ala Ser Lys Gly Ser Glu 
    210                 215                 220                 


Thr Cys Gly Phe Val Asp Glu Arg Gly Leu Tyr Lys Ser Leu Lys Gly 
225                 230                 235                 240 


Ala Cys Lys Leu Lys Leu Cys Gly Val Leu Gly Leu Arg Leu Met Asp 
                245                 250                 255     


Gly Thr Trp Val Ala Met Gln Thr Ser Asn Glu Thr Lys Trp Cys Pro 
            260                 265                 270         


Pro Asp Gln Leu Val Asn Leu His Asp Phe Arg Ser Asp Glu Ile Glu 
        275                 280                 285             


His Leu Val Val Glu Glu Leu Val Arg Lys Arg Glu Glu Cys Leu Asp 
    290                 295                 300                 


Ala Leu Glu Ser Ile Met Thr Thr Lys Ser Val Ser Phe Arg Arg Leu 
305                 310                 315                 320 


Ser His Leu Arg Lys Leu Val Pro Gly Phe Gly Lys Ala Tyr Thr Ile 
                325                 330                 335     


Phe Asn Lys Thr Leu Met Glu Ala Asp Ala His Tyr Lys Ser Val Arg 
            340                 345                 350         


Thr Trp Asn Glu Ile Leu Pro Ser Lys Gly Cys Leu Arg Val Gly Gly 
        355                 360                 365             


Arg Cys His Pro His Val Asn Gly Val Phe Phe Asn Gly Ile Ile Leu 
    370                 375                 380                 


Gly Pro Asp Gly Asn Val Leu Ile Pro Glu Met Gln Ser Ser Leu Leu 
385                 390                 395                 400 


Gln Gln His Met Glu Leu Leu Glu Ser Ser Val Ile Pro Leu Val His 
                405                 410                 415     


Pro Leu Ala Asp Pro Ser Thr Val Phe Lys Asp Gly Asp Glu Ala Glu 
            420                 425                 430         


Asp Phe Val Glu Val His Leu Pro Asp Val His Asn Gln Val Ser Gly 
        435                 440                 445             


Val Asp Leu Gly Leu Pro Asn Trp Gly Lys Tyr Val Leu Leu Ser Ala 
    450                 455                 460                 


Gly Ala Leu Thr Ala Leu Met Leu Ile Ile Phe Leu Met Thr Cys Cys 
465                 470                 475                 480 


Arg Arg Val Asn Arg Ser Glu Pro Thr Gln His Asn Leu Arg Gly Thr 
                485                 490                 495     


Gly Arg Glu Val Ser Val Thr Pro Gln Ser Gly Lys Ile Ile Ser Ser 
            500                 505                 510         


Trp Glu Ser His Lys Ser Gly Gly Glu Thr Arg Leu 
        515                 520                 


<210>  157
<211>  263
<212>  PRT
<213>  Ovine respiratory syncytial virus

<400>  157

Met Ser Asn His Thr His His Phe Glu Phe Lys Thr Leu Lys Lys Ala 
1               5                   10                  15      


Trp Lys Ala Ser Lys Tyr Phe Ile Val Gly Leu Ser Cys Leu Tyr Lys 
            20                  25                  30          


Leu Asn Leu Lys Ser Leu Val Gln Met Ala Leu Ser Ala Leu Ala Met 
        35                  40                  45              


Ile Thr Leu Val Ser Leu Thr Ile Thr Ala Ile Ile Tyr Ile Ser Thr 
    50                  55                  60                  


Gly Asn Thr Lys Ala Lys Pro Met Pro Thr Pro Thr Ile Gln Ile Thr 
65                  70                  75                  80  


Gln Gln Phe Gln Asn His Thr Ser Leu Pro Pro Thr Glu His Asn His 
                85                  90                  95      


Asn Ser Thr His Ser Pro Thr Gln Gly Thr Thr Ser Pro His Thr Phe 
            100                 105                 110         


Ala Val Asp Val Thr Glu Gly Thr Arg Tyr Tyr His Leu Thr Leu Lys 
        115                 120                 125             


Thr Gln Gly Gly Lys Thr Lys Gly Pro Pro Thr Pro His Ala Thr Arg 
    130                 135                 140                 


Lys Pro Pro Ile Ser Ser Gln Lys Ser Asn Pro Ser Glu Ile Gln Gln 
145                 150                 155                 160 


Asp Tyr Ser Asp Phe Gln Ile Leu Pro Tyr Val Pro Cys Asn Ile Cys 
                165                 170                 175     


Glu Gly Asp Ser Ala Cys Leu Ser Leu Cys Gln Asp Arg Ser Glu Ser 
            180                 185                 190         


Ile Leu Asp Lys Ala Leu Thr Thr Thr Pro Lys Lys Thr Pro Lys Pro 
        195                 200                 205             


Met Thr Thr Lys Lys Pro Thr Lys Thr Ser Thr His His Arg Thr Ser 
    210                 215                 220                 


Leu Arg Asn Lys Leu Tyr Ile Lys Thr Asn Met Thr Thr Pro Pro His 
225                 230                 235                 240 


Gly Leu Ile Ser Thr Ala Lys His Asn Lys Asn Gln Ser Thr Val Gln 
                245                 250                 255     


Asn Pro Arg His Thr Leu Ala 
            260             


<210>  158
<211>  297
<212>  PRT
<213>  Human respiratory syncytial virus A

<400>  158

Met Ser Lys Thr Lys Asp Gln Arg Thr Ala Lys Thr Leu Glu Arg Thr 
1               5                   10                  15      


Trp Asp Thr Leu Asn His Leu Leu Phe Ile Ser Ser Cys Leu Tyr Lys 
            20                  25                  30          


Leu Asn Leu Lys Ser Ile Ala Gln Ile Thr Leu Ser Ile Leu Ala Met 
        35                  40                  45              


Ile Ile Ser Thr Ser Leu Ile Ile Ala Ala Ile Ile Phe Ile Ala Ser 
    50                  55                  60                  


Ala Asn His Lys Val Thr Leu Thr Thr Ala Ile Ile Gln Asp Ala Thr 
65                  70                  75                  80  


Ser Gln Ile Lys Asn Thr Thr Gln Thr Tyr Leu Thr Gln Asn Thr Gln 
                85                  90                  95      


Leu Gly Ile Ser Phe Ser Asn Leu Ser Glu Thr Thr Ser Gln Pro Thr 
            100                 105                 110         


Thr Thr Pro Ala Leu Thr Thr Pro Ser Ala Lys Ser Thr Pro Gln Ser 
        115                 120                 125             


Thr Thr Val Lys Thr Lys Asn Thr Thr Thr Thr Gln Ile Gln Pro Ser 
    130                 135                 140                 


Lys Pro Thr Thr Lys Gln Arg Gln Lys Lys Pro Pro Asn Lys Pro Asn 
145                 150                 155                 160 


Asn Asp Phe His Phe Glu Val Phe Asn Phe Val Pro Cys Ser Ile Cys 
                165                 170                 175     


Ser Asn Asn Pro Thr Cys Trp Ala Ile Cys Lys Arg Ile Pro Asn Lys 
            180                 185                 190         


Lys Pro Gly Lys Lys Thr Thr Thr Lys Pro Thr Lys Lys Pro Thr Ile 
        195                 200                 205             


Lys Thr Thr Lys Lys Asp Leu Lys Pro Gln Thr Thr Lys Pro Lys Glu 
    210                 215                 220                 


Val Leu Thr Thr Lys Pro Thr Glu Lys Pro Thr Ile Asn Thr Thr Arg 
225                 230                 235                 240 


Thr Asn Ile Arg Thr Thr Leu Leu Thr Thr Asn Thr Thr Gly Asn Pro 
                245                 250                 255     


Glu Tyr Thr Ser Gln Lys Glu Thr Leu His Ser Thr Ser Pro Glu Gly 
            260                 265                 270         


Asn Pro Ser Pro Ser Gln Val Tyr Thr Thr Ser Glu Tyr Pro Ser Gln 
        275                 280                 285             


Pro Pro Ser Pro Ser Asn Thr Thr Asn 
    290                 295         


<210>  159
<211>  529
<212>  PRT
<213>  Piry virus

<400>  159

Met Asp Leu Phe Pro Ile Leu Val Val Val Leu Met Thr Asp Thr Val 
1               5                   10                  15      


Leu Gly Lys Phe Gln Ile Val Phe Pro Asp Gln Asn Glu Leu Glu Trp 
            20                  25                  30          


Arg Pro Val Val Gly Asp Ser Arg His Cys Pro Gln Ser Ser Glu Met 
        35                  40                  45              


Gln Phe Asp Gly Ser Arg Ser Gln Thr Ile Leu Thr Gly Lys Ala Pro 
    50                  55                  60                  


Val Gly Ile Thr Pro Ser Lys Ser Asp Gly Phe Ile Cys His Ala Ala 
65                  70                  75                  80  


Lys Trp Val Thr Thr Cys Asp Phe Arg Trp Tyr Gly Pro Lys Tyr Ile 
                85                  90                  95      


Thr His Ser Ile His His Leu Arg Pro Thr Thr Ser Asp Cys Glu Thr 
            100                 105                 110         


Ala Leu Gln Arg Tyr Lys Asp Gly Ser Leu Ile Asn Leu Gly Phe Pro 
        115                 120                 125             


Pro Glu Ser Cys Gly Tyr Ala Thr Val Thr Asp Ser Glu Ala Met Leu 
    130                 135                 140                 


Val Gln Val Thr Pro His His Val Gly Val Asp Asp Tyr Arg Gly His 
145                 150                 155                 160 


Trp Ile Asp Pro Leu Phe Pro Gly Gly Glu Cys Ser Thr Asn Phe Cys 
                165                 170                 175     


Asp Thr Val His Asn Ser Ser Val Trp Ile Pro Lys Ser Gln Lys Thr 
            180                 185                 190         


Asp Ile Cys Ala Gln Ser Phe Lys Asn Ile Lys Met Thr Ala Ser Tyr 
        195                 200                 205             


Pro Ser Glu Gly Ala Leu Val Ser Asp Arg Phe Ala Phe His Ser Ala 
    210                 215                 220                 


Tyr His Pro Asn Met Pro Gly Ser Thr Val Cys Ile Met Asp Phe Cys 
225                 230                 235                 240 


Glu Gln Lys Gly Leu Arg Phe Thr Asn Gly Glu Trp Met Gly Leu Asn 
                245                 250                 255     


Val Glu Gln Ser Ile Arg Glu Lys Lys Ile Ser Ala Ile Phe Pro Asn 
            260                 265                 270         


Cys Val Ala Gly Thr Glu Ile Arg Ala Thr Leu Glu Ser Glu Gly Ala 
        275                 280                 285             


Arg Thr Leu Thr Trp Glu Thr Gln Arg Met Leu Asp Tyr Ser Leu Cys 
    290                 295                 300                 


Gln Asn Thr Trp Asp Lys Val Ser Arg Lys Glu Pro Leu Ser Pro Leu 
305                 310                 315                 320 


Asp Leu Ser Tyr Leu Ser Pro Arg Ala Pro Gly Lys Gly Met Ala Tyr 
                325                 330                 335     


Thr Val Ile Asn Gly Thr Leu His Ser Ala His Ala Lys Tyr Ile Arg 
            340                 345                 350         


Thr Trp Ile Asp Tyr Gly Glu Met Lys Glu Ile Lys Gly Gly Arg Gly 
        355                 360                 365             


Glu Tyr Ser Lys Ala Pro Glu Leu Leu Trp Ser Gln Trp Phe Asp Phe 
    370                 375                 380                 


Gly Pro Phe Lys Ile Gly Pro Asn Gly Leu Leu His Thr Gly Lys Thr 
385                 390                 395                 400 


Phe Lys Phe Pro Leu Tyr Leu Ile Gly Ala Gly Ile Ile Asp Glu Asp 
                405                 410                 415     


Leu His Glu Leu Asp Glu Ala Ala Pro Ile Asp His Pro Gln Met Pro 
            420                 425                 430         


Asp Ala Lys Ser Val Leu Pro Glu Asp Glu Glu Ile Phe Phe Gly Asp 
        435                 440                 445             


Thr Gly Val Ser Lys Asn Pro Ile Glu Leu Ile Gln Gly Trp Phe Ser 
    450                 455                 460                 


Asn Trp Arg Glu Ser Val Met Ala Ile Val Gly Ile Val Leu Leu Ile 
465                 470                 475                 480 


Val Val Thr Phe Leu Ala Ile Lys Thr Val Arg Val Leu Asn Cys Leu 
                485                 490                 495     


Trp Arg Pro Arg Lys Lys Arg Ile Val Arg Gln Glu Val Asp Val Glu 
            500                 505                 510         


Ser Arg Leu Asn His Phe Glu Met Arg Gly Phe Pro Glu Tyr Val Lys 
        515                 520                 525             


Arg 
    


<210>  160
<211>  298
<212>  PRT
<213>  Human respiratory syncytial virus A

<400>  160

Met Ser Lys Thr Lys Asp Gln Arg Thr Ala Lys Thr Leu Glu Lys Thr 
1               5                   10                  15      


Trp Asp Thr Leu Asn His Leu Leu Phe Ile Ser Ser Cys Leu Tyr Lys 
            20                  25                  30          


Leu Asn Leu Lys Ser Ile Ala Gln Ile Thr Leu Ser Ile Leu Ala Met 
        35                  40                  45              


Ile Ile Ser Thr Ser Leu Ile Ile Ala Ala Ile Ile Phe Ile Ala Ser 
    50                  55                  60                  


Ala Asn Asn Lys Val Thr Leu Thr Thr Ala Ile Ile Gln Asp Ala Thr 
65                  70                  75                  80  


Ser Gln Ile Lys Asn Thr Thr Pro Thr Tyr Leu Thr Gln Asn Pro Gln 
                85                  90                  95      


Leu Gly Ile Ser Phe Phe Asn Leu Ser Gly Thr Thr Ser Gln Thr Thr 
            100                 105                 110         


Ala Ile Leu Ala Leu Thr Thr Pro Ser Val Glu Ser Ile Leu Gln Ser 
        115                 120                 125             


Thr Thr Val Lys Thr Lys Asn Thr Thr Thr Thr Gln Ile Gln Pro Ser 
    130                 135                 140                 


Lys Pro Thr Thr Lys Gln Arg Gln Asn Lys Pro Pro Asn Lys Pro Asn 
145                 150                 155                 160 


Asn Asp Phe His Phe Glu Val Phe Asn Phe Val Pro Cys Ser Ile Cys 
                165                 170                 175     


Ser Asn Asn Pro Thr Cys Trp Ala Ile Cys Lys Arg Ile Pro Ser Lys 
            180                 185                 190         


Lys Pro Gly Lys Lys Thr Thr Thr Lys Pro Thr Lys Lys Pro Thr Ile 
        195                 200                 205             


Lys Thr Thr Lys Lys Asp His Lys Pro Gln Thr Thr Lys Pro Lys Glu 
    210                 215                 220                 


Ala Pro Ser Thr Lys Pro Thr Glu Lys Pro Thr Ile Asn Ile Thr Lys 
225                 230                 235                 240 


Pro Asn Ile Arg Thr Thr Leu Leu Thr Asn Ser Thr Thr Gly Asn Leu 
                245                 250                 255     


Glu His Thr Ser Gln Glu Glu Thr Leu His Ser Thr Ser Ser Glu Gly 
            260                 265                 270         


Asn Thr Ser Pro Ser Gln Val Tyr Thr Thr Ser Glu Tyr Leu Ser Gln 
        275                 280                 285             


Pro Thr Ser Pro Ser Asn Ile Thr Asn Gln 
    290                 295             


<210>  161
<211>  524
<212>  PRT
<213>  Rabies virus

<400>  161

Met Val Pro Gln Ala Leu Leu Phe Val Pro Leu Leu Val Phe Pro Leu 
1               5                   10                  15      


Cys Phe Gly Lys Phe Pro Ile Tyr Thr Ile Pro Asp Lys Leu Gly Pro 
            20                  25                  30          


Trp Ser Pro Ile Asp Ile His His Leu Ser Cys Pro Asn Asn Leu Val 
        35                  40                  45              


Val Glu Asp Glu Gly Cys Thr Asn Leu Ser Gly Phe Ser Tyr Met Glu 
    50                  55                  60                  


Leu Lys Val Gly Tyr Ile Leu Ala Ile Lys Val Asn Gly Phe Thr Cys 
65                  70                  75                  80  


Thr Gly Val Val Thr Glu Ala Glu Thr Tyr Thr Asn Phe Val Gly Tyr 
                85                  90                  95      


Val Thr Thr Thr Phe Lys Arg Lys His Phe Arg Pro Thr Pro Asp Ala 
            100                 105                 110         


Cys Arg Ala Ala Tyr Asn Trp Lys Met Ala Gly Asp Pro Arg Tyr Glu 
        115                 120                 125             


Glu Ser Leu His Asn Pro Tyr Pro Asp Tyr Arg Trp Leu Arg Thr Val 
    130                 135                 140                 


Lys Thr Thr Lys Glu Ser Leu Val Ile Ile Ser Pro Ser Val Ala Asp 
145                 150                 155                 160 


Leu Asp Pro Tyr Asp Arg Ser Leu His Ser Arg Val Phe Pro Ser Gly 
                165                 170                 175     


Lys Cys Ser Gly Val Ala Val Ser Ser Thr Tyr Cys Ser Thr Asn His 
            180                 185                 190         


Asp Tyr Thr Ile Trp Met Pro Glu Asn Pro Arg Leu Gly Met Ser Cys 
        195                 200                 205             


Asp Ile Phe Thr Asn Ser Arg Gly Lys Arg Ala Ser Lys Gly Ser Glu 
    210                 215                 220                 


Thr Cys Gly Phe Val Asp Glu Arg Gly Leu Tyr Lys Ser Leu Lys Gly 
225                 230                 235                 240 


Ala Cys Lys Leu Lys Leu Cys Gly Val Leu Gly Leu Arg Leu Met Asp 
                245                 250                 255     


Gly Thr Trp Val Ser Met Gln Thr Ser Asn Glu Thr Lys Trp Cys Pro 
            260                 265                 270         


Pro Asp Lys Leu Val Asn Leu His Asp Phe Arg Ser Asp Glu Ile Glu 
        275                 280                 285             


His Leu Val Val Glu Glu Leu Val Arg Lys Arg Glu Glu Cys Leu Asp 
    290                 295                 300                 


Ala Leu Glu Ser Ile Met Thr Thr Lys Ser Val Ser Phe Arg Arg Leu 
305                 310                 315                 320 


Ser His Leu Arg Lys Leu Val Pro Gly Phe Gly Lys Ala Tyr Thr Ile 
                325                 330                 335     


Phe Asn Lys Thr Leu Met Glu Ala Asp Ala His Tyr Lys Ser Val Arg 
            340                 345                 350         


Thr Trp Asn Glu Ile Leu Pro Ser Lys Gly Cys Leu Arg Val Gly Gly 
        355                 360                 365             


Arg Cys His Pro His Val Asn Gly Val Phe Phe Asn Gly Ile Ile Leu 
    370                 375                 380                 


Gly Pro Asp Gly Asn Val Leu Ile Pro Glu Met Gln Ser Ser Leu Leu 
385                 390                 395                 400 


Gln Gln His Met Glu Leu Leu Glu Ser Ser Val Ile Pro Leu Val His 
                405                 410                 415     


Pro Leu Ala Asp Pro Ser Thr Val Phe Lys Asp Gly Asp Glu Ala Glu 
            420                 425                 430         


Asp Phe Val Glu Val His Leu Pro Asp Val His Asn Gln Val Ser Gly 
        435                 440                 445             


Val Asp Leu Gly Leu Pro Asn Trp Gly Lys Tyr Val Leu Leu Ser Ala 
    450                 455                 460                 


Gly Ala Leu Thr Ala Leu Met Leu Ile Ile Phe Leu Met Thr Cys Cys 
465                 470                 475                 480 


Arg Arg Val Asn Arg Ser Glu Pro Thr Gln His Asn Leu Arg Gly Thr 
                485                 490                 495     


Gly Arg Glu Val Ser Val Thr Pro Gln Ser Gly Lys Ile Ile Ser Ser 
            500                 505                 510         


Trp Glu Ser His Lys Ser Gly Gly Glu Thr Arg Leu 
        515                 520                 


<210>  162
<211>  526
<212>  PRT
<213>  Australian bat lyssavirus

<400>  162

Met Leu Leu Gln Ile Val Leu Leu Met Ser Leu Met Val Phe Ser Pro 
1               5                   10                  15      


Cys Pro Gly Lys Phe Pro Leu Tyr Thr Ile Pro Asp Lys Leu Gly Pro 
            20                  25                  30          


Trp Ser Pro Ile Asp Ile His His Leu Ser Cys Pro Asn Asn Leu Ile 
        35                  40                  45              


Val Glu Asp Glu Gly Cys Thr Ser Leu Ser Gly Phe Ser Tyr Met Glu 
    50                  55                  60                  


Leu Lys Val Gly Phe Ile Thr Thr Ile Lys Val Ser Gly Phe Thr Cys 
65                  70                  75                  80  


Thr Gly Val Val Thr Glu Ser Glu Thr Tyr Thr Asn Phe Phe Gly Tyr 
                85                  90                  95      


Val Thr Thr Thr Phe Lys Arg Lys His Phe Arg Pro Thr Pro Glu Phe 
            100                 105                 110         


Cys Arg Asn Ala Tyr Asn Trp Lys Val Ala Gly Asp Pro Arg Tyr Glu 
        115                 120                 125             


Glu Ser Leu His Asn Pro Tyr Pro Asp Tyr His Trp Leu Arg Thr Val 
    130                 135                 140                 


Thr Thr Thr Lys Glu Ser Leu Leu Ile Ile Ser Pro Ser Val Val Asp 
145                 150                 155                 160 


Met Asp Pro Tyr Asp Lys Ser Leu His Ser Lys Met Phe Pro Lys Gly 
                165                 170                 175     


Thr Cys Ser Gly Ala Ser Val Pro Ser Ile Phe Cys Ser Thr Asn His 
            180                 185                 190         


Asp Tyr Thr Leu Trp Met Pro Glu Asn Pro Lys Pro Gly Met Ser Cys 
        195                 200                 205             


Asp Ile Phe Thr Thr Ser Lys Gly Lys Lys Ala Ser Lys Gly Gly Lys 
    210                 215                 220                 


Val Cys Gly Phe Val Asp Glu Arg Gly Leu Tyr Lys Ser Leu Lys Gly 
225                 230                 235                 240 


Ala Cys Lys Leu Lys Leu Cys Gly Ile Ser Gly Leu Arg Leu Met Asp 
                245                 250                 255     


Gly Ser Trp Val Ser Ile Gln Asn His Glu Glu Ala Lys Trp Cys Ser 
            260                 265                 270         


Pro Asp Gln Leu Val Asn Ile His Asp Phe His Ser Asp Glu Ile Glu 
        275                 280                 285             


His Leu Ile Val Glu Glu Leu Val Arg Lys Arg Glu Glu Cys Leu Asp 
    290                 295                 300                 


Ala Leu Glu Ser Ile Met Thr Thr Lys Ser Val Ser Phe Arg Arg Leu 
305                 310                 315                 320 


Ser His Leu Arg Lys Leu Val Pro Gly Phe Gly Lys Ala Tyr Thr Ile 
                325                 330                 335     


Val Asn Lys Thr Leu Met Glu Ala Asp Ala His Tyr Lys Ser Val Arg 
            340                 345                 350         


Thr Trp Asn Glu Ile Ile Pro Ser Lys Gly Cys Leu Lys Val Arg Glu 
        355                 360                 365             


Arg Cys His Pro Pro Tyr Asn Gly Val Phe Phe Asn Gly Ile Ile Leu 
    370                 375                 380                 


Ser Pro Asp Gly His Val Leu Ile Pro Glu Met Gln Ser Ser Leu Leu 
385                 390                 395                 400 


Gln Gln His Val Glu Leu Leu Glu Ser Ser Val Ile Pro Leu Ile His 
                405                 410                 415     


Pro Leu Ala Asp Pro Ser Thr Val Phe Lys Arg Asp Asp Glu Ala Glu 
            420                 425                 430         


Asp Phe Ile Glu Val His Leu Pro Asp Val Gln Lys Gln Val Ser Gly 
        435                 440                 445             


Ile Asp Leu Gly Leu Ser Glu Trp Glu Arg Tyr Leu Ile Ile Gly Ala 
    450                 455                 460                 


Ser Ala Val Val Leu Phe Ala Leu Ala Ile Ile Phe Ala Val Cys Cys 
465                 470                 475                 480 


Arg Arg Cys Lys Arg Arg Lys Lys Ala Arg Thr Asp Arg Ile Glu Leu 
                485                 490                 495     


Asp Arg Lys Val Ser Val Thr Ser Gln Ser Gly Lys Val Ile Pro Ser 
            500                 505                 510         


Trp Glu Ser Tyr Lys Ile Glu Ala Gly Gly His Phe Arg Ser 
        515                 520                 525     


<210>  163
<211>  524
<212>  PRT
<213>  Rabies virus

<400>  163

Met Val Pro Gln Ala Leu Leu Phe Val Pro Leu Leu Val Phe Pro Leu 
1               5                   10                  15      


Cys Phe Gly Lys Phe Pro Ile Tyr Thr Ile Pro Asp Lys Leu Gly Pro 
            20                  25                  30          


Trp Ser Pro Ile Asp Ile His His Leu Ser Cys Pro Asn Asn Leu Val 
        35                  40                  45              


Val Glu Asp Glu Gly Cys Thr Asn Leu Ser Gly Phe Ser Tyr Met Glu 
    50                  55                  60                  


Leu Lys Val Gly Tyr Ile Leu Ala Ile Lys Met Asn Gly Phe Thr Cys 
65                  70                  75                  80  


Thr Gly Val Val Thr Glu Ala Glu Asn Tyr Thr Asn Phe Val Gly Tyr 
                85                  90                  95      


Val Thr Thr Thr Phe Lys Arg Lys His Leu Arg Pro Thr Pro Asp Ala 
            100                 105                 110         


Cys Arg Ala Ala Tyr Asn Trp Lys Met Ala Gly Asp Pro Arg Tyr Glu 
        115                 120                 125             


Glu Ser Leu His Asn Pro Tyr Pro Asp Tyr Ser Trp Leu Arg Thr Val 
    130                 135                 140                 


Lys Thr Thr Lys Glu Ser Leu Val Ile Ile Ser Pro Ser Val Ala Asp 
145                 150                 155                 160 


Leu Asp Pro Tyr Asp Arg Ser Leu His Ser Arg Val Phe Pro Ser Gly 
                165                 170                 175     


Lys Cys Ser Gly Val Ala Val Ser Ser Thr Tyr Cys Ser Thr Asn His 
            180                 185                 190         


Asp Tyr Thr Ile Trp Met Pro Glu Asn Pro Arg Leu Gly Lys Ser Cys 
        195                 200                 205             


Asp Ile Phe Thr Asn Ser Arg Gly Lys Arg Ala Ser Lys Gly Ser Glu 
    210                 215                 220                 


Thr Cys Gly Phe Val Asp Glu Arg Gly Leu Tyr Lys Ser Leu Lys Gly 
225                 230                 235                 240 


Ala Cys Lys Leu Lys Leu Cys Gly Val Leu Gly Leu Arg Leu Met Asp 
                245                 250                 255     


Gly Thr Trp Val Ala Met Gln Thr Ser Asn Glu Thr Lys Trp Cys Pro 
            260                 265                 270         


Pro Asp Gln Leu Val Asn Leu His Asp Phe Arg Ser Asp Glu Ile Glu 
        275                 280                 285             


His Leu Val Val Glu Glu Leu Val Arg Lys Arg Glu Glu Cys Leu Asp 
    290                 295                 300                 


Ala Leu Glu Ser Ile Met Thr Thr Lys Ser Val Ser Phe Arg Arg Leu 
305                 310                 315                 320 


Ser His Leu Arg Lys Leu Val Pro Gly Phe Gly Lys Ala Tyr Thr Ile 
                325                 330                 335     


Phe Asn Lys Thr Leu Met Glu Ala Asp Ala His Tyr Lys Ser Val Arg 
            340                 345                 350         


Thr Trp Asn Glu Ile Leu Pro Ser Lys Gly Cys Leu Arg Val Gly Gly 
        355                 360                 365             


Arg Cys His Pro His Val Asn Gly Val Phe Phe Asn Gly Ile Ile Leu 
    370                 375                 380                 


Gly Pro Asp Gly Asn Val Leu Ile Pro Glu Met Gln Ser Ser Leu Leu 
385                 390                 395                 400 


Gln Gln His Met Glu Leu Leu Glu Ser Ser Val Ile Pro Leu Val His 
                405                 410                 415     


Pro Leu Ala Asp Pro Ser Thr Val Phe Lys Asp Gly Asp Glu Ala Glu 
            420                 425                 430         


Asp Phe Val Glu Val His Leu Pro Asp Val His Asn Gln Val Ser Gly 
        435                 440                 445             


Val Asp Leu Gly Leu Pro Asn Trp Gly Lys Tyr Val Leu Leu Ser Ala 
    450                 455                 460                 


Gly Ala Leu Thr Ala Leu Met Leu Ile Ile Phe Leu Met Thr Cys Cys 
465                 470                 475                 480 


Arg Arg Val Asn Arg Ser Glu Pro Thr Gln His Asn Leu Arg Gly Thr 
                485                 490                 495     


Gly Arg Glu Val Ser Val Thr Pro Gln Thr Trp Lys Ile Ile Ser Ser 
            500                 505                 510         


Trp Glu Ser His Lys Ser Gly Gly Glu Thr Arg Leu 
        515                 520                 


<210>  164
<211>  526
<212>  PRT
<213>  Aravan virus

<400>  164

Met Pro Leu Gln Ala Ile Pro Leu Phe Ser Leu Ile Leu Pro Val Leu 
1               5                   10                  15      


Val Ala Gly Lys Phe Pro Ile Tyr Thr Ile Pro Asp Lys Ile Gly Pro 
            20                  25                  30          


Trp Ser Pro Ile Asp Ile Asn His Leu Ser Cys Pro Asn Asn Leu Val 
        35                  40                  45              


Val Glu Asp Glu Gly Cys Thr Thr Leu Thr Ala Phe Ser Tyr Met Glu 
    50                  55                  60                  


Leu Lys Val Gly Tyr Ile Thr Thr Ile Lys Val Ser Gly Phe Thr Cys 
65                  70                  75                  80  


Thr Gly Val Val Thr Glu Ala Glu Thr Tyr Thr Asn Phe Val Gly Tyr 
                85                  90                  95      


Val Thr Thr Thr Phe Arg Arg Lys His Phe Arg Pro Thr Ala Ser Ala 
            100                 105                 110         


Cys Arg Glu Ala Tyr Asn Trp Lys Ala Thr Gly Asp Pro Arg Tyr Glu 
        115                 120                 125             


Glu Ser Leu His Asn Pro Tyr Pro Asp Ser His Trp Leu Arg Thr Val 
    130                 135                 140                 


Lys Thr Thr Lys Glu Ser Leu Leu Ile Ile Ser Pro Ser Val Ala Asp 
145                 150                 155                 160 


Met Asp Ala Tyr Asp Lys Ala Leu Tyr Ser Lys Ile Phe Pro Asn Gly 
                165                 170                 175     


Lys Cys Leu Gly Val Ser Leu Ser Ser Pro Phe Cys Ser Thr Asn His 
            180                 185                 190         


Asp Tyr Thr Leu Trp Met Pro Glu Asn Pro Lys Pro Gly Val Ser Cys 
        195                 200                 205             


Asp Ile Phe Thr Thr Ser Lys Gly Lys Lys Ala Thr Lys Asp Gly Lys 
    210                 215                 220                 


Leu Cys Gly Phe Val Asp Glu Arg Gly Leu Tyr Lys Ser Leu Lys Gly 
225                 230                 235                 240 


Ala Cys Lys Leu Lys Leu Cys Gly Val Met Gly Leu Arg Leu Met Asp 
                245                 250                 255     


Gly Ser Trp Val Ser Leu Gln Lys Thr Glu Glu Ser Glu Trp Cys Ser 
            260                 265                 270         


Pro Asn Gln Leu Ile Asn Ile His Asp Phe His Ser Asp Glu Ile Glu 
        275                 280                 285             


His Met Val Val Glu Glu Leu Val Lys Lys Arg Glu Glu Cys Leu Asp 
    290                 295                 300                 


Ala Leu Glu Ser Ile Met Thr Thr Lys Ser Ile Ser Phe Arg Arg Leu 
305                 310                 315                 320 


Ser His Leu Arg Lys Leu Val Pro Gly Phe Gly Lys Ala Tyr Thr Leu 
                325                 330                 335     


Ile Asn Lys Thr Leu Met Glu Ala Asp Ala His Tyr Lys Ser Val Arg 
            340                 345                 350         


Glu Trp Thr Glu Val Ile Pro Ser Lys Gly Cys Leu Lys Ala Gly Gly 
        355                 360                 365             


Gly Cys Tyr Pro His Tyr Asn Arg Val Phe Phe Asn Gly Ile Ile Leu 
    370                 375                 380                 


Ser Pro Asp Gly His Val Leu Ile Pro Glu Met Gln Ser Ala Leu Leu 
385                 390                 395                 400 


Gln Gln His Ile Glu Leu Leu Glu Ser Ser Val Ile Pro Leu Arg His 
                405                 410                 415     


Pro Leu Ala Asp Pro Ser Thr Val Phe Lys Gly Asp Asp Glu Ala Glu 
            420                 425                 430         


Glu Phe Val Glu Val His Leu Pro Asp Thr Gln Lys Gln Ile Ser Gly 
        435                 440                 445             


Ile Asp Leu Gly Leu Pro Glu Trp Lys Arg Tyr Phe Leu Met Gly Met 
    450                 455                 460                 


Ser Ala Ile Gly Phe Leu Ala Leu Thr Ile Ile Leu Ala Val Cys Cys 
465                 470                 475                 480 


Arg Arg Ile Lys Arg Arg Lys Gln Ser Lys Pro Asn Pro Val Glu Leu 
                485                 490                 495     


Ile Arg Lys Val Ser Val Thr Ser Gln Ser Gly Arg Ala Ile Pro Ser 
            500                 505                 510         


Trp Glu Ser Tyr Lys Val Lys Thr Gly Asp Gln Pro Gln Val 
        515                 520                 525     


<210>  165
<211>  526
<212>  PRT
<213>  Sigma virus

<400>  165

Met Leu Ala Leu Ile Phe Ile Thr Thr Ser Val Trp Leu Ala Ala Ser 
1               5                   10                  15      


Gln Lys Thr Phe Thr Pro Asp Leu Val Phe Pro Glu Met Asn Arg Asn 
            20                  25                  30          


Ser Ser Trp Ser Val Ala Asn Tyr Gly Glu Ile Leu Cys Pro Thr Ser 
        35                  40                  45              


Phe Gln Ser Tyr Glu Pro Lys Lys His Gln Ile Leu Thr Arg Val Leu 
    50                  55                  60                  


Val Glu Arg Pro Ser Leu Asn Thr Asp Thr Lys Val Glu Gly Tyr Thr 
65                  70                  75                  80  


Cys His Lys Val Lys Tyr Glu Thr Ile Cys Asp Met Pro Trp Tyr Phe 
                85                  90                  95      


Ser Pro Thr Ile Ser His Ser Ile Ser Pro Leu Arg Val Lys Glu Ser 
            100                 105                 110         


Glu Cys Lys Asp Ala Ile Ala Glu His Gln Leu Gly Thr His Val Ser 
        115                 120                 125             


Leu Ser Phe Pro Pro Glu Asp Cys Ser Trp Asn Ser Val Asn Thr Lys 
    130                 135                 140                 


Ala Tyr Glu Asp Ile Ile Val Lys Asp His Pro Val Met Leu Asp Pro 
145                 150                 155                 160 


Tyr Thr Asn Asn Tyr Val Asp Ala Ile Phe Pro Gly Gly Ile Ser Ser 
                165                 170                 175     


Pro Gly Met Gly Gly Thr Ile His Asp Asp Met Met Trp Val Ser Lys 
            180                 185                 190         


Asp Leu Ala Val Ser Pro Glu Cys Ser Gly Gly Asn Lys Val Trp Gly 
        195                 200                 205             


Leu Phe Ile His Leu Gly Cys Met Gly Gly Gly Ser Arg Cys Trp Lys 
    210                 215                 220                 


Ser Ala Pro Pro His Arg Gly Pro Gln Gly Gln Glu Pro His Phe Ser 
225                 230                 235                 240 


Leu Pro Val Ser Phe Tyr Asn Lys Ile Gly Val Arg Phe His Asp Gly 
                245                 250                 255     


Glu Trp Met Lys Val Ser Val Asn Leu Asp His Pro Asn Ser Val Thr 
            260                 265                 270         


Phe Gln Val Thr Asp Phe Pro Pro Cys Pro Pro Gly Thr Thr Ile Gln 
        275                 280                 285             


Thr Ala Val Val Glu Asn Ile Asn Pro Glu Ile Gln Glu Leu Thr Val 
    290                 295                 300                 


Asn Met Met Tyr Arg Leu Lys Cys Gln Glu Thr Ile Ser Lys Met Val 
305                 310                 315                 320 


Ser Gly Leu Pro Thr Ser Val Phe Asp Leu Ser Tyr Leu Ile Gln Val 
                325                 330                 335     


Gln Glu Gly Pro Ser Ile Val Tyr Lys Arg Glu Lys Gly Val Leu Tyr 
            340                 345                 350         


Gln Ser Val Gly Met Tyr Gln Tyr Ile Asp Thr Val Thr Leu Asn Thr 
        355                 360                 365             


Glu Glu Asn Gln Leu Gly Glu Asn Ala Arg Gly Gln Lys Val Phe Trp 
    370                 375                 380                 


Thr Glu Trp Ser Asp Ser Pro Thr Arg Pro Asp Pro Gln Glu Gly Ser 
385                 390                 395                 400 


Asn Gly Phe Phe Lys Tyr Glu Gly Gln Ile Arg Val Pro Leu Gly Met 
                405                 410                 415     


Ser Leu Arg Leu Glu Ala Ala Thr Glu Leu Met Trp Gly His Pro Val 
            420                 425                 430         


His Thr Val Ser His Pro Ile Leu His Val Ile Ser Asn His Thr Glu 
        435                 440                 445             


Gln Ser Val Thr Thr Trp Asn Arg Gly Val Asn Ser Thr Asn Leu Ile 
    450                 455                 460                 


Gly Gln Ala Thr Arg Ser Ile Ser Gly Phe Tyr Asn Asp Leu Lys Leu 
465                 470                 475                 480 


Tyr Leu Ile Leu Ala Leu Ile Val Val Ser Ile Val Ala Leu Val Val 
                485                 490                 495     


Leu Asp Val Ile Pro Phe Lys Tyr Ile Leu Phe Ile Leu Cys Pro Pro 
            500                 505                 510         


Leu Leu Leu Cys Arg Phe Ile Lys Cys Ser Thr Lys Glu Ala 
        515                 520                 525     


<210>  166
<211>  507
<212>  PRT
<213>  Viral hemorrhagic septicemia virus

<400>  166

Met Glu Trp Asn Thr Phe Phe Leu Val Ile Leu Ile Ile Ile Ile Lys 
1               5                   10                  15      


Ser Thr Thr Pro Gln Ile Thr Gln Arg Pro Pro Val Glu Asn Ile Ser 
            20                  25                  30          


Thr Tyr His Ala Asp Trp Asp Thr Pro Leu Tyr Thr His Pro Ser Asn 
        35                  40                  45              


Cys Arg Asp Asp Ser Phe Val Pro Ile Arg Pro Ala Gln Leu Arg Cys 
    50                  55                  60                  


Pro His Glu Phe Glu Asp Ile Asn Lys Gly Leu Val Ser Val Pro Thr 
65                  70                  75                  80  


Arg Ile Ile His Leu Pro Leu Ser Val Thr Ser Val Ser Ala Val Ala 
                85                  90                  95      


Ser Gly His Tyr Leu His Arg Val Thr Tyr Arg Val Thr Cys Ser Thr 
            100                 105                 110         


Ser Phe Phe Gly Gly Gln Thr Ile Glu Lys Thr Ile Leu Glu Ala Lys 
        115                 120                 125             


Leu Ser Arg Gln Glu Ala Thr Asp Glu Ala Ser Lys Asp His Glu Tyr 
    130                 135                 140                 


Pro Phe Phe Pro Glu Pro Ser Cys Ile Trp Met Lys Asn Asn Val His 
145                 150                 155                 160 


Lys Asp Ile Thr His Tyr Tyr Lys Thr Pro Lys Thr Val Ser Val Asp 
                165                 170                 175     


Leu Tyr Ser Arg Lys Phe Leu Asn Pro Asp Phe Ile Glu Gly Val Cys 
            180                 185                 190         


Thr Thr Ser Pro Cys Gln Thr His Trp Gln Gly Val Tyr Trp Val Gly 
        195                 200                 205             


Ala Thr Pro Lys Ala His Cys Pro Thr Ser Glu Thr Leu Glu Gly His 
    210                 215                 220                 


Leu Phe Thr Arg Thr His Asp His Arg Val Val Lys Ala Ile Val Ala 
225                 230                 235                 240 


Gly His His Pro Trp Gly Leu Thr Met Ala Cys Thr Val Thr Phe Cys 
                245                 250                 255     


Gly Thr Glu Trp Ile Lys Thr Asp Leu Gly Asp Leu Ile Gln Val Thr 
            260                 265                 270         


Gly Pro Gly Gly Thr Arg Lys Leu Thr Pro Asn Lys Cys Val Asn Thr 
        275                 280                 285             


Asp Ile Gln Met Arg Gly Ala Thr Asp Asp Phe Ser Tyr Leu Asn His 
    290                 295                 300                 


Leu Ile Thr Asn Met Ala Gln Arg Thr Glu Cys Leu Asp Ala His Ser 
305                 310                 315                 320 


Asp Ile Thr Ala Ser Gly Lys Val Ser Ser Phe Leu Leu Ser Lys Phe 
                325                 330                 335     


Arg Pro Ser His Pro Gly Pro Gly Lys Ala His Tyr Leu Leu Asp Gly 
            340                 345                 350         


Gln Ile Met Arg Gly Asp Cys Asp Tyr Glu Ala Val Val Ser Ile Asn 
        355                 360                 365             


Tyr Asn Arg Ala Gln Tyr Lys Thr Met Asn Asn Thr Trp Lys Ser Trp 
    370                 375                 380                 


Lys Arg Val Asp Asn Asn Thr Asp Gly Tyr Asp Gly Met Ile Phe Gly 
385                 390                 395                 400 


Asp Lys Leu Ile Ile Pro Asp Ile Glu Lys Tyr Gln Ser Val Tyr Asp 
                405                 410                 415     


Ser Gly Met Leu Val Gln Arg Asn Leu Val Glu Val Pro His Leu Ser 
            420                 425                 430         


Ile Val Phe Val Ser Asn Thr Ser Asp Leu Ser Thr Asn His Ile His 
        435                 440                 445             


Thr Asn Leu Ile Pro Ser Asp Trp Ser Phe Asn Trp Ser Leu Trp Pro 
    450                 455                 460                 


Ser Leu Ser Gly Met Gly Val Val Gly Gly Ala Phe Leu Leu Leu Val 
465                 470                 475                 480 


Leu Cys Cys Cys Cys Lys Ala Ser Pro Pro Ile Pro Asn Tyr Gly Ile 
                485                 490                 495     


Pro Met Gln Gln Phe Ser Arg Ser Gln Thr Val 
            500                 505         


<210>  167
<211>  524
<212>  PRT
<213>  Rabies virus

<400>  167

Met Val Pro Gln Ala Leu Leu Phe Val Pro Leu Leu Val Phe Pro Leu 
1               5                   10                  15      


Cys Phe Gly Lys Phe Pro Ile Tyr Thr Ile Pro Asp Lys Leu Gly Pro 
            20                  25                  30          


Trp Ser Pro Ile Asp Ile His His Leu Ser Cys Pro Asn Asn Leu Val 
        35                  40                  45              


Val Glu Asp Glu Gly Cys Thr Asn Leu Ser Gly Phe Ser Tyr Met Glu 
    50                  55                  60                  


Leu Lys Val Gly Tyr Ile Ser Ala Ile Lys Met Asn Gly Phe Thr Cys 
65                  70                  75                  80  


Thr Gly Val Val Thr Glu Ala Glu Thr Tyr Thr Asn Phe Val Gly Tyr 
                85                  90                  95      


Val Thr Thr Thr Phe Lys Arg Lys His Phe Arg Pro Thr Pro Asp Ala 
            100                 105                 110         


Cys Arg Ala Ala Tyr Asn Trp Lys Met Ala Gly Asp Pro Arg Tyr Glu 
        115                 120                 125             


Glu Ser Leu His Asn Pro Tyr Pro Asp Tyr His Trp Leu Arg Thr Val 
    130                 135                 140                 


Lys Thr Thr Lys Glu Ser Leu Val Ile Ile Ser Pro Ser Val Ala Asp 
145                 150                 155                 160 


Leu Asp Pro Tyr Asp Arg Ser Leu His Ser Arg Val Phe Pro Gly Gly 
                165                 170                 175     


Asn Cys Ser Gly Val Ala Val Ser Ser Thr Tyr Cys Ser Thr Asn His 
            180                 185                 190         


Asp Tyr Thr Ile Trp Met Pro Glu Asn Pro Arg Leu Gly Met Ser Cys 
        195                 200                 205             


Asp Ile Phe Thr Asn Ser Arg Gly Lys Arg Ala Ser Lys Gly Ser Glu 
    210                 215                 220                 


Thr Cys Gly Phe Val Asp Glu Arg Gly Leu Tyr Lys Ser Leu Lys Gly 
225                 230                 235                 240 


Ala Cys Lys Leu Lys Leu Cys Gly Val Leu Gly Leu Arg Leu Met Asp 
                245                 250                 255     


Gly Thr Trp Val Ala Met Gln Thr Ser Asn Glu Thr Lys Trp Cys Pro 
            260                 265                 270         


Pro Gly Gln Leu Val Asn Leu His Asp Phe Arg Ser Asp Glu Ile Glu 
        275                 280                 285             


His Leu Val Val Glu Glu Leu Val Lys Lys Arg Glu Glu Cys Leu Asp 
    290                 295                 300                 


Ala Leu Glu Ser Ile Met Thr Thr Lys Ser Val Ser Phe Arg Arg Leu 
305                 310                 315                 320 


Ser His Leu Arg Lys Leu Val Pro Gly Phe Gly Lys Ala Tyr Thr Ile 
                325                 330                 335     


Phe Asn Lys Thr Leu Met Glu Ala Asp Ala His Tyr Lys Ser Val Arg 
            340                 345                 350         


Thr Trp Asn Glu Ile Ile Pro Ser Lys Gly Cys Leu Arg Val Gly Gly 
        355                 360                 365             


Arg Cys His Pro His Val Asn Gly Val Phe Phe Asn Gly Ile Ile Leu 
    370                 375                 380                 


Gly Pro Asp Gly Asn Val Leu Ile Pro Glu Met Gln Ser Ser Leu Leu 
385                 390                 395                 400 


Gln Gln His Met Glu Leu Leu Val Ser Ser Val Ile Pro Leu Met His 
                405                 410                 415     


Pro Leu Ala Asp Pro Ser Thr Val Phe Lys Asn Gly Asp Glu Ala Glu 
            420                 425                 430         


Asp Phe Val Glu Val His Leu Pro Asp Val His Glu Arg Ile Ser Gly 
        435                 440                 445             


Val Asp Leu Gly Leu Pro Asn Trp Gly Lys Tyr Val Leu Leu Ser Ala 
    450                 455                 460                 


Gly Ala Leu Thr Ala Leu Met Leu Ile Ile Phe Leu Met Thr Cys Trp 
465                 470                 475                 480 


Arg Arg Val Asn Arg Ser Glu Pro Thr Gln His Asn Leu Arg Gly Thr 
                485                 490                 495     


Gly Arg Glu Val Ser Val Thr Pro Gln Ser Gly Lys Ile Ile Ser Ser 
            500                 505                 510         


Trp Glu Ser Tyr Lys Ser Gly Gly Glu Thr Gly Leu 
        515                 520                 


<210>  168
<211>  257
<212>  PRT
<213>  Bovine respiratory syncytial virus

<400>  168

Met Ser Asn His Thr His His Leu Lys Phe Lys Thr Leu Lys Arg Ala 
1               5                   10                  15      


Trp Lys Ala Ser Lys Tyr Phe Ile Val Gly Leu Ser Cys Leu Tyr Lys 
            20                  25                  30          


Phe Asn Leu Lys Ser Leu Val Gln Thr Ala Leu Thr Thr Leu Ala Met 
        35                  40                  45              


Ile Thr Leu Thr Ser Leu Val Ile Thr Ala Leu Ile Tyr Ile Ser Val 
    50                  55                  60                  


Gly Asn Ala Lys Ala Lys Pro Thr Ser Lys Pro Thr Ile Gln Gln Thr 
65                  70                  75                  80  


Gln Arg Pro Gln Asn His Thr Ser Pro Leu Phe Thr Glu His Asn Tyr 
                85                  90                  95      


Lys Ser Thr His Thr Ser Ile Gln Ser Thr Thr Leu Ser Gln Leu Leu 
            100                 105                 110         


Asn Ile Asp Thr Thr Arg Gly Thr Thr Tyr Ser His Pro Thr Asp Glu 
        115                 120                 125             


Thr Gln Asn Arg Lys Ile Lys Ser Gln Ser Thr Leu Pro Ala Thr Arg 
    130                 135                 140                 


Gln Pro Pro Ile Asn Pro Ser Gly Ser Asn Pro Pro Glu Asn His Gln 
145                 150                 155                 160 


Asp His Asn Asn Ser Gln Thr Leu Pro Tyr Val Pro Cys Ser Thr Cys 
                165                 170                 175     


Glu Gly Asn Leu Ala Cys Ser Ser Leu Cys Gln Ile Gly Leu Glu Arg 
            180                 185                 190         


Ala Pro Ser Arg Ala Pro Thr Ile Thr Leu Lys Lys Ala Pro Lys Pro 
        195                 200                 205             


Lys Thr Thr Lys Lys Pro Thr Lys Thr Thr Ile His His Arg Thr Ser 
    210                 215                 220                 


Pro Glu Ala Lys Leu Gln Pro Lys Asn Asn Thr Ala Ala Pro Gln Gln 
225                 230                 235                 240 


Gly Ile Leu Ser Ser Pro Glu His His Thr Asn Gln Ser Thr Thr Gln 
                245                 250                 255     


Ile 
    


<210>  169
<211>  662
<212>  PRT
<213>  Tibrogargan virus

<400>  169

Met Glu Ala Ile Thr Ile Glu Ile Ile Ile Ile Ile Leu Thr Ile Ser 
1               5                   10                  15      


Tyr Pro Ile Leu Val Ala Pro Gln Leu Leu Tyr Asn Tyr Pro Phe Asn 
            20                  25                  30          


Cys Lys Lys Gly Pro Lys Met Thr Leu Asp Gly Leu Thr Cys Pro Leu 
        35                  40                  45              


Asp Phe Asn Thr Phe Asn Leu Asp Ser Lys Asp Asn Met Glu Ala Gly 
    50                  55                  60                  


Thr Met Cys Arg Pro Asn Pro Leu Ser Lys Asp Ile Glu Asp Gly Phe 
65                  70                  75                  80  


Leu Cys Tyr Lys Asp Thr Trp Val Thr Thr Cys Glu Glu Thr Trp Tyr 
                85                  90                  95      


Phe Ser Lys Thr Val Lys Asn His Ile Ile His Glu His Ile Thr Lys 
            100                 105                 110         


Asp Glu Cys Phe Glu Ala Leu Ala Thr Tyr Lys Leu Gly Lys His Val 
        115                 120                 125             


Glu Pro Phe Phe Pro Ala Pro Ser Cys Tyr Trp Ser Ala Thr Asn Glu 
    130                 135                 140                 


Glu Arg Ala Thr Phe Val Asn Ile Gln Pro His Gly Val Leu Leu Asp 
145                 150                 155                 160 


Pro Tyr Ser Gly Lys Ile Lys Asp Pro Leu Ile Asp Ser Asp Asn Cys 
                165                 170                 175     


Asp Asn Asp Phe Cys Val Thr Arg Ser His Gln Thr His Trp Leu Arg 
            180                 185                 190         


Asn Arg Lys Pro Asp Ile Met Glu Arg Cys Asn Asn Glu Thr Trp Glu 
        195                 200                 205             


Cys His Pro Ile Lys Ile Tyr Tyr Gly Trp Val Ser Lys Lys Lys Asn 
    210                 215                 220                 


Gln Glu Thr Ser Thr Thr Phe Asn Tyr Val Gln Thr Gly Leu Val Ile 
225                 230                 235                 240 


Glu Ser Gln Tyr Ile Gly His Val Leu Met Ala Asp Leu Cys Ile Met 
                245                 250                 255     


Thr Phe Cys Asn Arg Asp Gly Tyr Leu Phe Pro Asp Gly Ser Trp Trp 
            260                 265                 270         


Glu Ile Lys Tyr Ser Leu Tyr His Ala Phe Thr Lys Asp His Thr Val 
        275                 280                 285             


Leu Asn Asn Ala His Lys Cys Gly Asp Arg Thr His Gly Asp His Leu 
    290                 295                 300                 


Thr Glu Phe Gln Arg Asp Lys Lys Val Gly Tyr Glu Asp Leu Glu Ile 
305                 310                 315                 320 


Asn Leu Glu Gly Leu Glu Met Arg Gln Lys Ser Arg Ser Ile Asn Met 
                325                 330                 335     


Met Cys Leu Asn Arg Leu Ala Glu Ile Arg Asn Thr His His Ile Asn 
            340                 345                 350         


Val Leu Asp Met Ser Tyr Leu Thr Pro Lys His Pro Gly Arg Gly Leu 
        355                 360                 365             


Ala Tyr Tyr Phe Ser Gln Asp Gln Lys Asn Ser Ser Lys Tyr His Val 
    370                 375                 380                 


Lys Val Leu Asp Cys Asp Tyr Lys Leu Ile His Ile His Asp Ala Asp 
385                 390                 395                 400 


Ile Lys Gly Phe Val Asn Ile Thr Lys Tyr Pro Glu Pro Asn Val Thr 
                405                 410                 415     


Ile Leu Gly Leu Lys Asp Asn Leu Thr Phe Ala Asp Leu Gly Ile Ser 
            420                 425                 430         


Arg Cys Gln Asp Leu Thr Pro Leu Asn Gly Ser Arg Asn Ile Ser Cys 
        435                 440                 445             


Glu Glu Ser Ser Gly Pro Leu His Ser Asp Asp Ser Arg Leu Ser Asn 
    450                 455                 460                 


Gly Lys Arg Phe Trp Thr Arg His Ser Phe Gln Gly Ala Asn Phe His 
465                 470                 475                 480 


Glu His Pro Gly Val Arg Ile Gly Val Asn Gly Ile Thr Tyr Asp Ile 
                485                 490                 495     


Arg Lys Gln Ile Leu Arg Phe Pro Ser Thr Ser Asn Leu Leu Trp Asp 
            500                 505                 510         


Leu Pro Ser Tyr Tyr Ser Thr Lys His Arg Val His Phe Phe Gln His 
        515                 520                 525             


Pro Thr Lys His Glu Ile Arg Lys Asn Phe Thr Gly Ser Asp Ser Arg 
    530                 535                 540                 


Asp Ile Asp Val Leu Asp Asp Leu Ile Asn Arg His Ile Asn Arg Thr 
545                 550                 555                 560 


Asp Phe Pro Thr Arg Ile Arg Asn Trp Ile Gly Asn Ile Glu Asp Lys 
                565                 570                 575     


Val Glu His Phe Phe Ser Asn Val Gly Gly Thr Ile Lys Thr Ile Ile 
            580                 585                 590         


Ser Leu Val Leu Phe Val Ile Gly Thr Leu Ile Ser Ile Lys Val Trp 
        595                 600                 605             


Lys Lys Cys Lys Arg His Pro Gln Lys Thr Lys Lys Val Ala Gln Leu 
    610                 615                 620                 


Lys Leu Asn Asp Tyr Glu Lys Thr Tyr Asn Gln Arg Asp Thr Ser Asn 
625                 630                 635                 640 


Asn Asn Asn Asp Asp Leu Tyr Glu Thr Ile Glu Asn Gly Gly Thr Val 
                645                 650                 655     


Tyr Ser Pro Phe His Val 
            660         


<210>  170
<211>  508
<212>  PRT
<213>  Infectious hematopoietic necrosis virus

<400>  170

Met Asp Thr Met Ile Thr Thr Pro Leu Ile Leu Ile Leu Ile Thr Cys 
1               5                   10                  15      


Gly Ala Asn Ser Gln Thr Val Lys Pro Asp Thr Ala Ser Glu Ser Asp 
            20                  25                  30          


Gln Pro Thr Trp Ser Asn Pro Leu Phe Thr Tyr Pro Glu Gly Cys Thr 
        35                  40                  45              


Leu Asp Lys Leu Ser Lys Val Asn Ala Ser Gln Leu Arg Cys Pro Arg 
    50                  55                  60                  


Ile Phe Asp Asp Glu Asn Arg Gly Leu Ile Ala Tyr Pro Thr Ser Ile 
65                  70                  75                  80  


Arg Ser Leu Ser Val Gly Asn Asp Leu Gly Glu Ile His Thr Gln Gly 
                85                  90                  95      


Asn His Ile His Lys Val Leu Tyr Arg Thr Ile Cys Ser Thr Gly Phe 
            100                 105                 110         


Phe Gly Gly Gln Thr Ile Glu Lys Ala Leu Val Glu Met Lys Leu Ser 
        115                 120                 125             


Thr Lys Glu Ala Gly Ala Tyr Asp Thr Thr Thr Ala Ala Ala Leu Tyr 
    130                 135                 140                 


Phe Pro Ala Pro Arg Cys Gln Trp Tyr Thr Asp Asn Val Gln Asn Asp 
145                 150                 155                 160 


Leu Ile Phe Tyr Tyr Thr Thr Gln Lys Ser Val Leu Arg Asp Pro Tyr 
                165                 170                 175     


Thr Arg Asp Phe Leu Asp Ser Asp Phe Ile Gly Gly Lys Cys Thr Lys 
            180                 185                 190         


Ser Pro Cys Gln Thr His Trp Ser Asn Val Val Trp Met Gly Asp Ala 
        195                 200                 205             


Gly Ile Pro Ala Cys Asp Ser Ser Gln Glu Ile Lys Ala His Leu Phe 
    210                 215                 220                 


Val Asp Lys Ile Ser Asn Arg Val Val Lys Ala Thr Ser Tyr Gly His 
225                 230                 235                 240 


His Pro Trp Gly Leu His Arg Ala Cys Met Ile Glu Phe Cys Gly Lys 
                245                 250                 255     


Gln Trp Ile Arg Thr Asp Leu Gly Asp Leu Ile Ser Val Glu Tyr Asn 
            260                 265                 270         


Ser Gly Ala Glu Ile Leu Ser Phe Pro Lys Cys Glu Asp Lys Thr Met 
        275                 280                 285             


Gly Met Arg Gly Asn Leu Asp Asp Phe Ala Tyr Leu Asp Asp Leu Val 
    290                 295                 300                 


Lys Ala Ser Glu Ser Arg Glu Glu Cys Leu Glu Ala His Ala Glu Ile 
305                 310                 315                 320 


Ile Ser Thr Asn Ser Val Thr Pro Tyr Leu Leu Ser Lys Phe Arg Ser 
                325                 330                 335     


Pro His Pro Gly Ile Asn Asp Val Tyr Ala Met His Lys Gly Ser Ile 
            340                 345                 350         


Tyr His Gly Met Cys Met Thr Val Ala Val Asp Glu Val Ser Lys Asp 
        355                 360                 365             


Arg Thr Thr Tyr Arg Ala His Arg Ala Thr Ser Phe Thr Lys Trp Glu 
    370                 375                 380                 


Arg Pro Phe Gly Asp Glu Trp Glu Gly Phe His Gly Leu His Gly Asn 
385                 390                 395                 400 


Asn Thr Thr Ile Ile Pro Asp Leu Glu Lys Tyr Val Ala Gln Tyr Lys 
                405                 410                 415     


Thr Ser Met Met Glu Pro Met Ser Ile Lys Ser Val Pro His Pro Ser 
            420                 425                 430         


Ile Leu Ala Phe Tyr Asn Glu Thr Asp Leu Ser Gly Ile Ser Ile Arg 
        435                 440                 445             


Lys Leu Asp Ser Phe Asp Leu Gln Ser Leu His Trp Ser Phe Trp Pro 
    450                 455                 460                 


Thr Ile Ser Ala Leu Gly Gly Ile Pro Leu Val Leu Leu Leu Ala Val 
465                 470                 475                 480 


Ala Ala Cys Cys Cys Trp Ser Gly Arg Pro Pro Thr Pro Ser Ala Pro 
                485                 490                 495     


Gln Ser Ile Pro Met Tyr His Leu Ala Asn Arg Ser 
            500                 505             


<210>  171
<211>  292
<212>  PRT
<213>  Human respiratory syncytial virus B

<400>  171

Met Ser Lys His Lys Asn Gln Arg Thr Ala Arg Thr Leu Glu Lys Thr 
1               5                   10                  15      


Trp Asp Thr Leu Asn His Leu Ile Val Ile Ser Ser Cys Leu Tyr Arg 
            20                  25                  30          


Leu Asn Leu Lys Ser Ile Ala Gln Ile Ala Leu Ser Val Leu Ala Met 
        35                  40                  45              


Ile Ile Ser Thr Ser Leu Ile Ile Ala Ala Ile Ile Phe Ile Ile Ser 
    50                  55                  60                  


Ala Asn His Lys Val Thr Leu Thr Thr Val Thr Val Gln Thr Ile Lys 
65                  70                  75                  80  


Asn His Thr Glu Lys Asn Ile Ser Thr Tyr Leu Thr Gln Val Pro Pro 
                85                  90                  95      


Glu Arg Val Asn Ser Ser Lys Gln Pro Thr Thr Thr Ser Pro Ile His 
            100                 105                 110         


Thr Asn Ser Ala Thr Ile Ser Pro Asn Thr Lys Ser Glu Thr His His 
        115                 120                 125             


Thr Thr Ala Gln Thr Lys Gly Arg Ile Thr Thr Ser Thr Gln Thr Asn 
    130                 135                 140                 


Lys Pro Ser Thr Lys Ser Arg Ser Lys Asn Pro Pro Lys Lys Pro Lys 
145                 150                 155                 160 


Asp Asp Tyr His Phe Glu Val Phe Asn Phe Val Pro Cys Ser Ile Cys 
                165                 170                 175     


Gly Asn Asn Gln Leu Cys Lys Ser Ile Cys Lys Thr Ile Pro Ser Asn 
            180                 185                 190         


Lys Pro Lys Lys Lys Pro Thr Ile Lys Pro Thr Asn Lys Pro Thr Thr 
        195                 200                 205             


Lys Thr Thr Asn Lys Arg Asp Pro Lys Thr Pro Ala Lys Met Pro Lys 
    210                 215                 220                 


Lys Glu Ile Ile Thr Asn Pro Ala Lys Lys Pro Thr Leu Lys Thr Thr 
225                 230                 235                 240 


Glu Arg Asp Thr Ser Ile Ser Gln Ser Thr Val Leu Asp Thr Ile Thr 
                245                 250                 255     


Pro Lys Tyr Thr Ile Gln Gln Gln Ser Leu His Ser Thr Thr Ser Glu 
            260                 265                 270         


Asn Thr Pro Ser Ser Thr Gln Ile Pro Thr Ala Ser Glu Pro Ser Thr 
        275                 280                 285             


Leu Asn Pro Asn 
    290         


<210>  172
<211>  660
<212>  PRT
<213>  Adelaide River virus

<400>  172

Met Ala Thr Phe Lys Val Leu Val Leu Met Ile Leu Trp Ile Thr Ser 
1               5                   10                  15      


Ile Phe Asn Val Arg Cys Glu Lys Phe Val Thr Ile Pro Val Asn Cys 
            20                  25                  30          


Ser Gly Glu Val Asp Ile Asp Lys Met Asp Val Met Cys Pro Asn Arg 
        35                  40                  45              


Tyr Asn Leu Leu Ser Thr Asn His Leu Met Glu Gly Glu Glu Val Glu 
    50                  55                  60                  


Thr Phe Cys Arg Pro Ser Leu Arg Glu Asn Asp Leu Leu Asp Gly Tyr 
65                  70                  75                  80  


Leu Cys Arg Lys Gln Lys Trp Glu Val Thr Cys Thr Glu Thr Trp Tyr 
                85                  90                  95      


Phe Val Thr Asp Val Lys Tyr Gln Ile Ile Glu Val Ile Pro Thr Glu 
            100                 105                 110         


Asn Glu Cys Met Glu Glu Arg Glu Arg Lys Leu Lys Gly Glu Tyr Ile 
        115                 120                 125             


Pro Pro Tyr Tyr Pro Pro Thr Asn Cys Val Trp Asn Ala Ile Asp Thr 
    130                 135                 140                 


Gln Glu Arg Thr Phe Ile Thr Leu Ile Glu His Pro Val Ile Glu Asp 
145                 150                 155                 160 


Pro Val Thr Met Thr Leu Met Asp Ser Lys Phe Thr Lys Pro Cys Asn 
                165                 170                 175     


Pro Lys His Asn Glu Val Thr Ile Cys Asp Thr Tyr Asn Pro Leu Ile 
            180                 185                 190         


Lys Trp Ile Ser Lys Glu Thr Ser Gly Leu Asn Leu His Cys Gln Ile 
        195                 200                 205             


Lys Ser Trp Glu Cys Ile Pro Val Lys Leu His His Ser His Arg Asn 
    210                 215                 220                 


Met Met Glu Ala Leu Tyr Leu Glu Ser Pro Asp Phe Gly Ile Val Asp 
225                 230                 235                 240 


Ala Ser Lys Ile Cys Asn Leu Thr Phe Cys Gly Tyr Asn Gly Ile Leu 
                245                 250                 255     


Leu Asp Asn Gly Glu Trp Trp Ser Ile Tyr Arg Ser Gly Phe Thr His 
            260                 265                 270         


Gly Phe Leu Asp Asn His Ile Leu Lys Asn Arg Arg Ile Glu Glu Cys 
        275                 280                 285             


Lys Glu Lys Lys Pro Gly Tyr Lys Leu Ala Lys Leu Asp Thr Thr Tyr 
    290                 295                 300                 


Ile Asp Leu Glu Phe Glu Ile Glu Leu Glu His Glu Lys Cys Leu Gly 
305                 310                 315                 320 


Thr Leu Glu Lys Leu Gln Asn Gly Glu Tyr Val Thr Pro Leu Asp Leu 
                325                 330                 335     


Ser Tyr Leu Ser Pro Ser Asn Pro Gly Lys His Tyr Ala Tyr Arg Leu 
            340                 345                 350         


Glu Tyr Ile Asn Thr Thr Glu His Lys Cys Val Gln Leu Gly Phe Thr 
        355                 360                 365             


Tyr Glu Gly Gly Asp Cys Arg Lys Met Leu Asp Glu Arg Asp Asp His 
    370                 375                 380                 


Gly Ala Tyr Tyr Asn Trp Thr Thr Ile Lys Leu Gln Arg Val Ile Arg 
385                 390                 395                 400 


Ala Val Cys Tyr Tyr His Thr Phe Ser Met Asn Leu Asp Glu Ser Lys 
                405                 410                 415     


His Lys Tyr Tyr Asp Gln Asp Asn Arg Ser Ile Gln Ile Asp Glu Lys 
            420                 425                 430         


Phe Ile Ser Glu Val Leu Lys Ser Thr Pro Leu Ile Asp Arg His Glu 
        435                 440                 445             


Lys Tyr Glu Gly Asn Leu Ser Trp Asn Gly Ile Ile Ile Glu Ser Lys 
    450                 455                 460                 


Asn Gly His Glu Lys Asn Val Ile Val Pro Ser Ala Ser Gln Tyr Asn 
465                 470                 475                 480 


His Val Met Ile Asn Lys Ile Leu Lys Arg Leu Asp Thr Val Met Tyr 
                485                 490                 495     


Asp Ser Tyr Lys Phe Asp Ser Glu Ser Gly Ser Ile Ser Tyr Asn Lys 
            500                 505                 510         


Ile Val Pro Ile Val Arg Glu Asp Asn Leu Gln Asn Ala His Arg Val 
        515                 520                 525             


Asp Val Ile Gln Tyr Ile Lys Asp Lys Gly Ser Tyr Ile Ile Asn Gly 
    530                 535                 540                 


Phe Thr Gly Trp Phe Ser Ser Leu Gly Lys Leu Met Arg Trp Thr Ile 
545                 550                 555                 560 


Trp Gly Val Gly Leu Phe Phe Ser Ile Phe Thr Leu Tyr Lys Ile Ile 
                565                 570                 575     


Met Ile Leu Arg Lys His Ser Asn Asp Asn Val Arg Lys Glu Phe Lys 
            580                 585                 590         


Glu Thr Ala Gly Lys Val Met Ile Gly Gln Pro Ile Asp Thr Lys Ser 
        595                 600                 605             


Met Ser Arg Thr Ser Ile Lys Ala Asn Asn Lys Gly Lys Phe Asp Lys 
    610                 615                 620                 


Val Lys Asp Leu Phe Thr Pro Arg Ser Lys Thr Ile Ser His Leu Thr 
625                 630                 635                 640 


Thr Asp Thr Leu Lys Glu His Thr Asp Gly Thr Tyr Glu Glu Leu His 
                645                 650                 655     


Phe Phe Asn Val 
            660 


<210>  173
<211>  525
<212>  PRT
<213>  Australian bat lyssavirus

<400>  173

Met Leu Leu Gln Val Ile Leu Leu Val Ser Leu Thr Ala Ile Leu Pro 
1               5                   10                  15      


Cys Thr Gly Gln Phe Pro Leu Tyr Ala Ile Pro Asp Lys Leu Gly Pro 
            20                  25                  30          


Trp Ser Pro Ile Asp Ile His His Leu Ser Cys Pro Asn Asn Leu Ile 
        35                  40                  45              


Val Glu Asp Glu Gly Cys Thr Ser Leu Ser Gly Phe Ser Tyr Met Glu 
    50                  55                  60                  


Leu Lys Val Gly Phe Ile Thr Thr Ile Lys Val Ser Gly Phe Thr Cys 
65                  70                  75                  80  


Thr Gly Val Val Thr Glu Ser Glu Thr Tyr Thr Asn Phe Phe Gly Tyr 
                85                  90                  95      


Val Thr Thr Thr Phe Lys Arg Lys His Phe Arg Pro Thr Pro Glu Ser 
            100                 105                 110         


Cys Arg Lys Ala Tyr Asn Trp Lys Ile Ala Gly Asp Pro Arg Tyr Glu 
        115                 120                 125             


Glu Ser Leu His Asn Pro Tyr Pro Asp Tyr His Trp Leu Arg Thr Val 
    130                 135                 140                 


Thr Thr Thr Lys Glu Ser Leu Leu Ile Ile Ser Pro Ser Val Val Asp 
145                 150                 155                 160 


Met Asp Pro Tyr Asp Lys Ser Leu His Ser Arg Met Phe Pro Lys Gly 
                165                 170                 175     


Ser Cys Ser Gly Ala Ser Ile Pro Ser Val Phe Cys Ser Thr Asn His 
            180                 185                 190         


Asp Tyr Thr Leu Trp Met Pro Glu Asp Ser Asn Ser Gly Met Ser Cys 
        195                 200                 205             


Asp Ile Phe Thr Met Ser Lys Gly Lys Lys Ala Ser Lys Gly Gly Lys 
    210                 215                 220                 


Val Cys Gly Phe Val Asp Glu Arg Gly Leu Tyr Lys Ser Leu Lys Gly 
225                 230                 235                 240 


Ala Cys Lys Leu Lys Leu Cys Gly Ile Ser Gly Leu Arg Leu Leu Asp 
                245                 250                 255     


Gly Ser Trp Val Ser Ile Gln Asn His Glu Glu Val Lys Trp Cys Ser 
            260                 265                 270         


Pro Asn Gln Leu Val Asn Ile His Asp Phe Asn Ala Asp Glu Ile Glu 
        275                 280                 285             


His Leu Ile Val Glu Glu Leu Ile Lys Glu Arg Glu Glu Cys Leu Asp 
    290                 295                 300                 


Ala Leu Glu Ser Ile Ile Thr Thr Lys Ser Val Ser Phe Arg Arg Leu 
305                 310                 315                 320 


Ser His Leu Arg Lys Leu Val Pro Gly Phe Gly Lys Ala Tyr Thr Ile 
                325                 330                 335     


Ile Asn Lys Thr Leu Met Glu Ala Asp Ala His Tyr Lys Ser Val Arg 
            340                 345                 350         


Thr Trp Asp Glu Ile Ile Pro Ser Lys Gly Cys Leu Lys Val Arg Glu 
        355                 360                 365             


Lys Cys His Pro Pro Tyr Asn Gly Val Phe Phe Asn Gly Ile Ile Leu 
    370                 375                 380                 


Gly Pro Asp Gly Gln Val Leu Ile Pro Glu Met Gln Ser Ser Leu Leu 
385                 390                 395                 400 


His Gln His Thr Glu Leu Leu Glu Ser Ser Val Ile Pro Leu Ile His 
                405                 410                 415     


Pro Leu Ala Asp Pro Ser Thr Ile Phe Arg Gly Asp Asp Glu Ala Glu 
            420                 425                 430         


Gly Phe Ile Glu Val His Leu Pro Asp Ile Gln Lys Gln Val Ser Gly 
        435                 440                 445             


Ile Asp Leu Gly Leu Ser Glu Trp Glu Arg Tyr Leu Ile Ile Gly Ile 
    450                 455                 460                 


Ser Ala Ile Ile Leu Phe Ile Leu Ala Ile Ile Phe Thr Ile Cys Cys 
465                 470                 475                 480 


Arg Arg Cys Lys Arg Arg Lys Lys Ile Arg Thr Asp His Ile Glu Leu 
                485                 490                 495     


Asp Arg Lys Val Ser Val Thr Ser Gln Ser Gly Lys Ser Ile Pro Ser 
            500                 505                 510         


Trp Glu Ser Tyr Lys Ser Arg Gln Gly His Ser Arg Ser 
        515                 520                 525 


<210>  174
<211>  623
<212>  PRT
<213>  Bovine ephemeral fever virus

<400>  174

Met Phe Lys Val Leu Ile Ile Thr Leu Leu Val Asn Lys Ile His Leu 
1               5                   10                  15      


Glu Lys Ile Tyr Asn Val Pro Val Asn Cys Gly Glu Leu His Pro Val 
            20                  25                  30          


Lys Ala His Glu Ile Lys Cys Pro Gln Arg Leu Asn Glu Leu Ser Leu 
        35                  40                  45              


Gln Ala His His Asn Leu Ala Lys Asp Glu His Tyr Asn Lys Ile Cys 
    50                  55                  60                  


Arg Pro Gln Leu Lys Asp Asp Ala His Leu Glu Gly Phe Ile Cys Arg 
65                  70                  75                  80  


Lys Gln Arg Trp Ile Thr Lys Cys Ser Glu Thr Trp Tyr Phe Ser Thr 
                85                  90                  95      


Ser Ile Glu Tyr Gln Ile Leu Glu Val Ile Pro Glu Tyr Ser Gly Cys 
            100                 105                 110         


Thr Asp Ala Val Lys Lys Leu Asp Gln Gly Ala Leu Ile Pro Pro Tyr 
        115                 120                 125             


Tyr Pro Pro Ala Gly Cys Phe Trp Asn Thr Glu Met Asn Gln Glu Ile 
    130                 135                 140                 


Glu Phe Tyr Val Leu Ile Gln His Lys Pro Phe Leu Asn Pro Tyr Asp 
145                 150                 155                 160 


Asn Leu Ile Tyr Asp Ser Arg Phe Leu Thr Pro Cys Thr Ile Asn Asp 
                165                 170                 175     


Ser Lys Thr Lys Gly Cys Pro Leu Lys Asp Ile Thr Gly Thr Trp Ile 
            180                 185                 190         


Pro Asp Val Arg Val Glu Glu Ile Ser Glu His Cys Asn Asn Lys His 
        195                 200                 205             


Trp Glu Cys Ile Thr Val Lys Ser Phe Arg Ser Glu Leu Asn Asp Lys 
    210                 215                 220                 


Glu Arg Leu Trp Glu Ala Pro Asp Ile Gly Leu Val His Val Asn Lys 
225                 230                 235                 240 


Gly Cys Leu Ser Thr Phe Cys Gly Lys Asn Gly Ile Ile Phe Glu Asp 
                245                 250                 255     


Gly Glu Trp Trp Ser Ile Glu Asn Gln Thr Glu Ser Asp Phe Gln Asn 
            260                 265                 270         


Phe Lys Ile Glu Lys Cys Lys Gly Lys Lys Pro Gly Phe Arg Met His 
        275                 280                 285             


Thr Asp Arg Thr Glu Phe Glu Glu Leu Asp Ile Lys Ala Glu Leu Glu 
    290                 295                 300                 


His Glu Arg Cys Leu Asn Thr Ile Ser Lys Ile Leu Asn Lys Glu Asn 
305                 310                 315                 320 


Ile Asn Thr Leu Asp Met Ser Tyr Leu Ala Pro Thr Arg Pro Gly Arg 
                325                 330                 335     


Asp Tyr Ala Tyr Leu Phe Glu Gln Thr Ser Trp Gln Glu Lys Leu Cys 
            340                 345                 350         


Leu Ser Leu Pro Asp Ser Gly Arg Val Ser Lys Asp Cys Asn Ile Asp 
        355                 360                 365             


Trp Arg Thr Ser Thr Arg Gly Gly Met Val Lys Lys Asn His Tyr Gly 
    370                 375                 380                 


Ile Gly Ser Tyr Lys Arg Ala Trp Cys Glu Tyr Arg Pro Phe Val Asp 
385                 390                 395                 400 


Lys Asn Glu Asp Gly Tyr Ile Asp Ile Gln Glu Leu Asn Gly His Asn 
                405                 410                 415     


Met Ser Gly Asn His Ala Ile Leu Glu Thr Ala Pro Ala Gly Gly Ser 
            420                 425                 430         


Ser Gly Asn Arg Leu Asn Val Thr Leu Asn Gly Met Ile Phe Val Glu 
        435                 440                 445             


Pro Thr Lys Leu Tyr Leu His Thr Lys Ser Leu Tyr Glu Gly Ile Glu 
    450                 455                 460                 


Asp Tyr Gln Lys Leu Ile Lys Phe Glu Val Met Glu Tyr Asp Asn Val 
465                 470                 475                 480 


Glu Glu Asn Leu Ile Arg Tyr Glu Glu Asp Glu Lys Phe Lys Pro Val 
                485                 490                 495     


Asn Leu Asn Pro His Glu Lys Ser Gln Ile Asn Arg Thr Asp Ile Val 
            500                 505                 510         


Arg Glu Ile Gln Lys Gly Gly Lys Lys Val Leu Ser Ala Val Val Gly 
        515                 520                 525             


Trp Phe Thr Ser Thr Ala Lys Ala Val Arg Trp Thr Ile Trp Ala Val 
    530                 535                 540                 


Gly Ala Ile Val Thr Thr Tyr Ala Ile Tyr Lys Leu Tyr Lys Met Val 
545                 550                 555                 560 


Lys Ser Asn Ser Ser His Ser Lys His Arg Glu Ala Asp Leu Glu Gly 
                565                 570                 575     


Leu Gln Ser Thr Thr Lys Glu Asn Met Arg Val Glu Lys Asn Asp Lys 
            580                 585                 590         


Asn Tyr Gln Asp Leu Glu Leu Gly Leu Tyr Glu Glu Ile Arg Ser Ile 
        595                 600                 605             


Lys Gly Gly Ser Lys Gln Thr Gly Asp Asp Arg Phe Phe Asp His 
    610                 615                 620             


<210>  175
<211>  523
<212>  PRT
<213>  Isfahan virus

<400>  175

Met Thr Ser Val Leu Phe Met Val Gly Val Leu Leu Gly Ala Phe Gly 
1               5                   10                  15      


Ser Thr His Cys Ser Ile Gln Ile Val Phe Pro Ser Glu Thr Lys Leu 
            20                  25                  30          


Val Trp Lys Pro Val Leu Lys Gly Thr Arg Tyr Cys Pro Gln Ser Ala 
        35                  40                  45              


Glu Leu Asn Leu Glu Pro Asp Leu Lys Thr Met Ala Phe Asp Ser Lys 
    50                  55                  60                  


Val Pro Ile Gly Ile Thr Pro Ser Asn Ser Asp Gly Tyr Leu Cys His 
65                  70                  75                  80  


Ala Ala Lys Trp Val Thr Thr Cys Asp Phe Arg Trp Tyr Gly Pro Lys 
                85                  90                  95      


Tyr Ile Thr His Ser Val His Ser Leu Arg Pro Thr Val Ser Asp Cys 
            100                 105                 110         


Lys Ala Ala Val Glu Ala Tyr Asn Ala Gly Thr Leu Met Tyr Pro Gly 
        115                 120                 125             


Phe Pro Pro Glu Ser Cys Gly Tyr Ala Ser Ile Thr Asp Ser Glu Phe 
    130                 135                 140                 


Tyr Val Met Leu Val Thr Pro His Pro Val Gly Val Asp Asp Tyr Arg 
145                 150                 155                 160 


Gly His Trp Val Asp Pro Leu Phe Pro Thr Ser Glu Cys Asn Ser Asn 
                165                 170                 175     


Phe Cys Glu Thr Val His Asn Ala Thr Met Trp Ile Pro Lys Asp Leu 
            180                 185                 190         


Lys Thr His Asp Val Cys Ser Gln Asp Phe Gln Thr Ile Arg Val Ser 
        195                 200                 205             


Val Met Tyr Pro Gln Thr Lys Pro Thr Lys Gly Ala Asp Leu Thr Leu 
    210                 215                 220                 


Lys Ser Lys Phe His Ala His Met Lys Gly Asp Arg Val Cys Lys Met 
225                 230                 235                 240 


Lys Phe Cys Asn Lys Asn Gly Leu Arg Leu Gly Asn Gly Glu Trp Ile 
                245                 250                 255     


Glu Val Gly Asp Glu Val Met Leu Asp Asn Ser Lys Leu Leu Ser Leu 
            260                 265                 270         


Phe Pro Asp Cys Leu Val Gly Ser Val Val Lys Ser Thr Leu Leu Ser 
        275                 280                 285             


Glu Gly Val Gln Thr Ala Leu Trp Glu Thr Asp Arg Leu Leu Asp Tyr 
    290                 295                 300                 


Ser Leu Cys Gln Asn Thr Trp Glu Lys Ile Asp Arg Lys Glu Pro Leu 
305                 310                 315                 320 


Ser Ala Val Asp Leu Ser Tyr Leu Ala Pro Arg Ser Pro Gly Lys Gly 
                325                 330                 335     


Met Ala Tyr Ile Val Ala Asn Gly Ser Leu Met Ser Ala Pro Ala Arg 
            340                 345                 350         


Tyr Ile Arg Val Trp Ile Asp Ser Pro Ile Leu Lys Glu Ile Lys Gly 
        355                 360                 365             


Lys Lys Glu Ser Ala Ser Gly Ile Asp Thr Val Leu Trp Glu Gln Trp 
    370                 375                 380                 


Leu Pro Phe Asn Gly Met Glu Leu Gly Pro Asn Gly Leu Ile Lys Thr 
385                 390                 395                 400 


Lys Ser Gly Tyr Lys Phe Pro Leu Tyr Leu Leu Gly Met Gly Ile Val 
                405                 410                 415     


Asp Gln Asp Leu Gln Glu Leu Ser Ser Val Asn Pro Val Asp His Pro 
            420                 425                 430         


His Val Pro Ile Ala Gln Ala Phe Val Ser Glu Gly Glu Glu Val Phe 
        435                 440                 445             


Phe Gly Asp Thr Gly Val Ser Lys Asn Pro Ile Glu Leu Ile Ser Gly 
    450                 455                 460                 


Trp Phe Ser Asp Trp Lys Glu Thr Ala Ala Ala Leu Gly Phe Ala Ala 
465                 470                 475                 480 


Ile Ser Val Ile Leu Ile Ile Gly Leu Met Arg Leu Leu Pro Leu Leu 
                485                 490                 495     


Cys Arg Arg Arg Lys Gln Lys Lys Val Ile Tyr Lys Asp Val Glu Leu 
            500                 505                 510         


Asn Ser Phe Asp Pro Arg Gln Ala Phe His Arg 
        515                 520             


<210>  176
<211>  524
<212>  PRT
<213>  Rabies virus

<400>  176

Met Ile Pro Gln Ala Leu Leu Phe Val Pro Leu Leu Ile Pro Ser Leu 
1               5                   10                  15      


Cys Leu Gly Lys Phe Pro Ile Tyr Thr Ile Pro Asp Lys Leu Gly Pro 
            20                  25                  30          


Trp Ser Pro Ile Asp Ile His His Leu Ser Cys Pro Asn Asn Leu Val 
        35                  40                  45              


Val Glu Asp Glu Gly Cys Thr Ser Leu Ser Gly Phe Ser Tyr Met Glu 
    50                  55                  60                  


Leu Lys Val Gly Tyr Ile Ser Ala Met Lys Val Asn Gly Phe Thr Cys 
65                  70                  75                  80  


Thr Gly Val Val Thr Glu Ala Glu Thr Tyr Thr Asn Phe Val Gly Tyr 
                85                  90                  95      


Val Thr Thr Thr Phe Lys Arg Lys His Phe Arg Pro Met Pro Asp Ala 
            100                 105                 110         


Cys Arg Ala Ala His Asp Trp Lys Ile Ala Gly Asp Pro Arg Tyr Glu 
        115                 120                 125             


Asp Ser Leu Gln Asn Pro Tyr Pro Asp Tyr His Trp Leu Arg Thr Val 
    130                 135                 140                 


Lys Thr Thr Lys Glu Ser Leu Val Ile Ile Ser Pro Ser Val Ala Asp 
145                 150                 155                 160 


Leu Asp Pro Tyr Asp Lys Ser Leu His Ser Arg Val Phe Pro Ser Gly 
                165                 170                 175     


Lys Cys Leu Gly Ile Thr Val Ser Ser Thr Tyr Cys Pro Thr Asn His 
            180                 185                 190         


Asp Tyr Thr Ile Trp Met Pro Val Glu Ala Arg Leu Gly Thr Ser Cys 
        195                 200                 205             


Asp Ile Phe Thr Asn Ser Arg Gly Lys Lys Ala Ser Lys Gly Gly Arg 
    210                 215                 220                 


Thr Cys Gly Phe Val Asp Glu Arg Gly Leu Tyr Lys Ser Leu Lys Gly 
225                 230                 235                 240 


Ala Cys Lys Leu Lys Leu Cys Gly Val Pro Gly Leu Arg Leu Met Asn 
                245                 250                 255     


Gly Thr Trp Val Ser Ile Gln Thr Ser Asp Asp Ile Lys Trp Cys Pro 
            260                 265                 270         


Pro Asp Gln Leu Val Asn Leu His Asp Phe His Ser Asp Glu Ile Glu 
        275                 280                 285             


His Leu Val Val Glu Glu Leu Ile Lys Lys Arg Glu Gly Cys Leu Asp 
    290                 295                 300                 


Ala Leu Glu Ser Ile Met Thr Thr Lys Ser Val Ser Phe Arg Arg Leu 
305                 310                 315                 320 


Ser His Leu Arg Lys Leu Val Pro Gly Phe Gly Lys Ala Tyr Thr Ile 
                325                 330                 335     


Phe Asn Asn Thr Leu Met Glu Ala Asp Ala His Tyr Lys Ser Val Arg 
            340                 345                 350         


Thr Trp Asn Glu Val Ile Pro Ser Lys Gly Cys Leu Lys Val Gly Gly 
        355                 360                 365             


Arg Cys His Pro Pro Val Asn Gly Val Phe Phe Asn Gly Ile Ile Leu 
    370                 375                 380                 


Gly Pro Asp Gly Asn Val Leu Ile Pro Glu Met Gln Ser Ser Leu Leu 
385                 390                 395                 400 


Gln Gln His Met Glu Leu Leu Glu Ser Ser Val Ile Pro Leu Met His 
                405                 410                 415     


Pro Leu Ala Asp Pro Ser Thr Val Phe Lys Asp Gly Asp Glu Ala Glu 
            420                 425                 430         


Asp Phe Val Glu Val His Leu Pro Asp Val His Lys Gln Val Ser Asp 
        435                 440                 445             


Val Asp Leu Gly Leu Pro Ser Trp Gly Lys Tyr Leu Leu Met Ser Ala 
    450                 455                 460                 


Gly Ala Leu Ala Thr Leu Ile Leu Ala Ile Phe Leu Ile Thr Cys Cys 
465                 470                 475                 480 


Arg Arg Ala Asn Arg Thr Lys Ser Thr Gln Arg Gly His Arg Glu Ser 
                485                 490                 495     


Gly Gly Lys Val Ser Val Ala Pro Gln Asn Gly Lys Ile Ile Ser Ser 
            500                 505                 510         


Trp Glu Leu Tyr Lys Ser Glu Ser Glu Thr Gly Met 
        515                 520                 


<210>  177
<211>  512
<212>  PRT
<213>  Snakehead rhabdovirus

<400>  177

Met Thr Leu Pro Asn Met Lys Pro Lys Arg Ile Val Leu Phe Leu Val 
1               5                   10                  15      


Phe Leu Asn Ala Trp Val Ser Asn Ala Gln Val Thr His Lys Pro Arg 
            20                  25                  30          


Pro Asp Ser Ile Val Glu Tyr Ser Glu Glu Trp Glu Asn Pro Ile Tyr 
        35                  40                  45              


Thr Thr Pro Ser His Cys Phe Glu Asp Thr Phe Ala Pro Val Lys Pro 
    50                  55                  60                  


Glu Lys Leu Arg Cys Pro His Ile Phe Asp Asp Gln Asn Leu Gly Leu 
65                  70                  75                  80  


Thr Ala Ser Lys Ala Lys Ile Leu His Met Asp Leu Lys Pro Glu Asp 
                85                  90                  95      


Thr His Phe Glu Ala Lys Gly Arg Leu Leu His Lys Val Thr Tyr Gln 
            100                 105                 110         


Val Leu Cys Ser Thr Gly Phe Phe Gly Gly Arg Thr Val Thr Arg Lys 
        115                 120                 125             


Val Leu Glu Thr Pro Met Gly Asp Asn Glu Ala Gln Ala Tyr Lys Ala 
    130                 135                 140                 


Val Asp Arg Glu Phe Pro Tyr Phe Pro Glu Pro Leu Cys Phe Trp Leu 
145                 150                 155                 160 


Arg Asp Asn Val Ala Ala Glu Arg Val Phe His Phe Ser Thr Pro Lys 
                165                 170                 175     


Thr Val Thr Val Asp Leu Tyr Ser Arg Lys Tyr Ile Ser Pro Asp Phe 
            180                 185                 190         


Val Gly Gly Gln Cys Ala Lys Ser Pro Cys Pro Thr His Trp Pro Asn 
        195                 200                 205             


Val Tyr Trp Val Gly Glu Thr Gln Ser Pro Glu Cys Pro Ser Ile Asp 
    210                 215                 220                 


Thr Glu Gly Gly His Ile Phe Thr Lys Lys Asp Thr His Arg Ile Thr 
225                 230                 235                 240 


Lys Ala Val Val His Gly His His Pro Trp Gly Leu Thr Lys Ala Cys 
                245                 250                 255     


Gln Ile Gln Phe Cys Asn Glu Gln Trp Ile Arg Thr Asp Leu Gly Asp 
            260                 265                 270         


Leu Ile Arg Ile Glu Pro Asn Asp Gly Thr Ser Ser Leu Thr Leu Pro 
        275                 280                 285             


Lys Cys Gln Asp Asn Val Val Gln Met Arg Gly Asn Leu Asp Asp Phe 
    290                 295                 300                 


Ser Tyr Leu Asn His Ala Ile Val Asn Met Ala Gln Arg Ser Glu Cys 
305                 310                 315                 320 


Leu Glu Ala His Ser Ser Ile Val Ala Gln Gln Lys Val Ser Pro Tyr 
                325                 330                 335     


Leu Leu Ser Lys Phe Arg Pro Pro His Pro Gly Leu Gly Lys Ala His 
            340                 345                 350         


Tyr Leu Gln Asn Asn Thr Ile Met Arg Gly Asp Cys Ile Tyr Glu Gly 
        355                 360                 365             


Val Ala Glu Ile Ser Glu Asn Arg Thr Thr Tyr Arg Asn Leu Lys Gly 
    370                 375                 380                 


Glu Trp Lys Lys Trp Ser Leu Ser Arg Gly Gly Glu Gly Tyr Asp Gly 
385                 390                 395                 400 


Met Thr Val Gly Thr Lys Ile Val Ile Pro Asp Leu Glu Lys Tyr Gln 
                405                 410                 415     


Ser Ile Tyr Asp Asn Gly Met Phe Ile Pro Lys Leu Leu Gly Glu Val 
            420                 425                 430         


Pro His Pro Ser Ile Val Ile Thr Tyr Asn Gln Thr Asp Ser Ile Glu 
        435                 440                 445             


Thr Gly Ile Phe Thr Asp Gly Lys Leu Leu Asn Met Gly Val Asn Trp 
    450                 455                 460                 


Thr Leu Trp Pro Ser Leu Ser Gly Ile Ser Leu Phe Thr Val Ala Ser 
465                 470                 475                 480 


Leu Ile Leu Ile Trp Tyr Cys Cys Cys Arg Val Thr Pro Gln Ala Leu 
                485                 490                 495     


Asn Tyr Ser Ile Pro Met His Thr Ile Thr Ser Arg Gly Val Glu Ile 
            500                 505                 510         


<210>  178
<211>  508
<212>  PRT
<213>  Infectious hematopoietic necrosis virus

<400>  178

Met Asp Thr Met Ile Thr Thr Pro Leu Ile Leu Ile Leu Ile Thr Cys 
1               5                   10                  15      


Gly Ala Asn Ser Gln Thr Val Lys Pro Asp Thr Ala Ser Glu Ser Asp 
            20                  25                  30          


Gln Pro Thr Trp Ser Asn Pro Leu Phe Thr Tyr Pro Glu Gly Cys Thr 
        35                  40                  45              


Leu Asp Lys Leu Ser Lys Val Asn Ala Ser Gln Leu Arg Cys Pro Arg 
    50                  55                  60                  


Ile Phe Asp Asp Glu Asn Arg Gly Leu Ile Ala Tyr Pro Thr Ser Ile 
65                  70                  75                  80  


Arg Ser Leu Ser Val Gly Asn Asp Leu Gly Asp Ile His Thr Gln Gly 
                85                  90                  95      


Asn His Ile His Lys Val Leu Tyr Arg Thr Ile Cys Ser Thr Gly Phe 
            100                 105                 110         


Phe Gly Gly Gln Thr Ile Glu Lys Ala Leu Val Lys Met Lys Leu Ser 
        115                 120                 125             


Thr Lys Glu Ala Gly Ala Tyr Asp Thr Thr Thr Ala Ala Ala Leu Tyr 
    130                 135                 140                 


Phe Pro Ala Pro Arg Cys Gln Trp Tyr Thr Asp Asn Val Gln Asn Asp 
145                 150                 155                 160 


Leu Ile Phe Tyr Tyr Thr Thr Gln Lys Ser Val Leu Arg Asp Pro Tyr 
                165                 170                 175     


Thr Arg Asp Phe Leu Asp Ser Asp Phe Ile Gly Gly Lys Cys Thr Lys 
            180                 185                 190         


Ser Pro Cys Gln Thr His Trp Ser Asn Val Val Trp Met Gly Asp Ala 
        195                 200                 205             


Gly Ile Pro Ala Cys Asp Ser Ser Gln Glu Ile Lys Ala His Leu Phe 
    210                 215                 220                 


Val Asp Lys Ile Ser Asn Arg Val Val Lys Ala Thr Ser Tyr Gly His 
225                 230                 235                 240 


His Pro Trp Gly Leu His Gln Ala Cys Met Ile Glu Phe Cys Gly Gln 
                245                 250                 255     


Gln Trp Ile Arg Thr Asp Leu Gly Asp Leu Ile Ser Val Val Tyr Asn 
            260                 265                 270         


Ser Gly Ser Glu Ile Leu Ser Phe Pro Lys Cys Glu Asp Lys Thr Val 
        275                 280                 285             


Gly Met Arg Gly Asn Leu Asp Asp Phe Ala Tyr Leu Asp Asp Leu Val 
    290                 295                 300                 


Lys Ala Ser Glu Ser Arg Glu Glu Cys Leu Glu Ala His Ala Glu Ile 
305                 310                 315                 320 


Ile Ser Thr Asn Ser Val Thr Pro Tyr Leu Leu Ser Lys Phe Arg Ser 
                325                 330                 335     


Pro His Pro Gly Ile Asn Asp Val Tyr Ala Met His Lys Gly Ser Ile 
            340                 345                 350         


Tyr His Gly Met Cys Met Thr Val Ala Val Asp Glu Val Ser Lys Asp 
        355                 360                 365             


Arg Thr Thr Tyr Arg Ala His Arg Ala Thr Ser Phe Thr Lys Trp Glu 
    370                 375                 380                 


Arg Pro Phe Gly Asp Glu Trp Glu Gly Phe His Gly Leu His Gly Asn 
385                 390                 395                 400 


Asn Thr Thr Ile Ile Pro Asp Leu Glu Lys Tyr Val Ala Gln Tyr Lys 
                405                 410                 415     


Met Ser Met Met Glu Pro Met Ser Ile Lys Ser Val Pro His Pro Ser 
            420                 425                 430         


Ile Leu Ala Leu Tyr Asn Glu Thr Asp Val Ser Gly Ile Ser Ile Arg 
        435                 440                 445             


Lys Leu Asp Ser Phe Asp Leu Gln Ser Leu His Trp Ser Phe Trp Pro 
    450                 455                 460                 


Thr Ile Ser Ala Leu Gly Gly Ile Pro Phe Val Leu Leu Leu Ala Val 
465                 470                 475                 480 


Ala Ala Cys Cys Cys Trp Ser Gly Arg Pro Pro Thr Pro Ser Val Pro 
                485                 490                 495     


Gln Ser Ile Pro Met Tyr His Leu Ala Asn Arg Ser 
            500                 505             


<210>  179
<211>  676
<212>  PRT
<213>  Zaire ebolavirus

<400>  179

Met Gly Val Thr Gly Ile Leu Gln Leu Pro Arg Asp Arg Phe Lys Arg 
1               5                   10                  15      


Thr Ser Phe Phe Leu Trp Val Ile Ile Leu Phe Gln Arg Thr Phe Ser 
            20                  25                  30          


Ile Pro Leu Gly Val Ile His Asn Ser Thr Leu Gln Val Ser Asp Val 
        35                  40                  45              


Asp Lys Leu Val Cys Arg Asp Lys Leu Ser Ser Thr Asn Gln Leu Arg 
    50                  55                  60                  


Ser Val Gly Leu Asn Leu Glu Gly Asn Gly Val Ala Thr Asp Val Pro 
65                  70                  75                  80  


Ser Ala Thr Lys Arg Trp Gly Phe Arg Ser Gly Val Pro Pro Lys Val 
                85                  90                  95      


Val Asn Tyr Glu Ala Gly Glu Trp Ala Glu Asn Cys Tyr Asn Leu Glu 
            100                 105                 110         


Ile Lys Lys Pro Asp Gly Ser Glu Cys Leu Pro Ala Ala Pro Asp Gly 
        115                 120                 125             


Ile Arg Gly Phe Pro Arg Cys Arg Tyr Val His Lys Val Ser Gly Thr 
    130                 135                 140                 


Gly Pro Cys Ala Gly Asp Phe Ala Phe His Lys Glu Gly Ala Phe Phe 
145                 150                 155                 160 


Leu Tyr Asp Arg Leu Ala Ser Thr Val Ile Tyr Arg Gly Thr Thr Phe 
                165                 170                 175     


Ala Glu Gly Val Val Ala Phe Leu Ile Leu Pro Gln Ala Lys Lys Asp 
            180                 185                 190         


Phe Phe Ser Ser His Pro Leu Arg Glu Pro Val Asn Ala Thr Glu Asp 
        195                 200                 205             


Pro Ser Ser Gly Tyr Tyr Ser Thr Thr Ile Arg Tyr Gln Ala Thr Gly 
    210                 215                 220                 


Phe Gly Thr Asn Glu Thr Glu Tyr Leu Phe Glu Val Asp Asn Leu Thr 
225                 230                 235                 240 


Tyr Val Gln Leu Glu Ser Arg Phe Thr Pro Gln Phe Leu Leu Gln Leu 
                245                 250                 255     


Asn Glu Thr Ile Tyr Thr Ser Gly Lys Arg Ser Asn Thr Thr Gly Lys 
            260                 265                 270         


Leu Ile Trp Lys Val Asn Pro Glu Ile Asp Thr Thr Ile Gly Glu Trp 
        275                 280                 285             


Ala Phe Trp Glu Thr Lys Lys Asn Leu Thr Arg Lys Ile Arg Ser Glu 
    290                 295                 300                 


Glu Leu Ser Phe Thr Ala Val Ser Asn Arg Ala Lys Asn Ile Ser Gly 
305                 310                 315                 320 


Gln Ser Pro Ala Arg Thr Ser Ser Asp Pro Gly Thr Asn Thr Thr Thr 
                325                 330                 335     


Glu Asp His Lys Ile Met Ala Ser Glu Asn Ser Ser Ala Met Val Gln 
            340                 345                 350         


Val His Ser Gln Gly Arg Glu Ala Ala Val Ser His Leu Thr Thr Leu 
        355                 360                 365             


Ala Thr Ile Ser Thr Ser Pro Gln Pro Pro Thr Thr Lys Pro Gly Pro 
    370                 375                 380                 


Asp Asn Ser Thr His Asn Thr Pro Val Tyr Lys Leu Asp Ile Ser Glu 
385                 390                 395                 400 


Ala Thr Gln Val Glu Gln His His Arg Arg Thr Asp Asn Asp Ser Thr 
                405                 410                 415     


Ala Ser Asp Thr Pro Pro Ala Thr Thr Ala Ala Gly Pro Leu Lys Ala 
            420                 425                 430         


Glu Asn Thr Asn Thr Ser Lys Gly Thr Asp Leu Leu Asp Pro Ala Thr 
        435                 440                 445             


Thr Thr Ser Pro Gln Asn His Ser Glu Thr Ala Gly Asn Asn Asn Thr 
    450                 455                 460                 


His His Gln Asp Thr Gly Glu Glu Ser Ala Ser Ser Gly Lys Leu Gly 
465                 470                 475                 480 


Leu Ile Thr Asn Thr Ile Ala Gly Val Ala Gly Leu Ile Thr Gly Gly 
                485                 490                 495     


Arg Arg Ala Arg Arg Glu Ala Ile Val Asn Ala Gln Pro Lys Cys Asn 
            500                 505                 510         


Pro Asn Leu His Tyr Trp Thr Thr Gln Asp Glu Gly Ala Ala Ile Gly 
        515                 520                 525             


Leu Ala Trp Ile Pro Tyr Phe Gly Pro Ala Ala Glu Gly Ile Tyr Thr 
    530                 535                 540                 


Glu Gly Leu Met His Asn Gln Asp Gly Leu Ile Cys Gly Leu Arg Gln 
545                 550                 555                 560 


Leu Ala Asn Glu Thr Thr Gln Ala Leu Gln Leu Phe Leu Arg Ala Thr 
                565                 570                 575     


Thr Glu Leu Arg Thr Phe Ser Ile Leu Asn Arg Lys Ala Ile Asp Phe 
            580                 585                 590         


Leu Leu Gln Arg Trp Gly Gly Thr Cys His Ile Leu Gly Pro Asp Cys 
        595                 600                 605             


Cys Ile Glu Pro His Asp Trp Thr Lys Asn Ile Thr Asp Lys Ile Asp 
    610                 615                 620                 


Gln Ile Ile His Asp Phe Val Asp Lys Thr Leu Pro Asp Gln Gly Asp 
625                 630                 635                 640 


Asn Asp Asn Trp Trp Thr Gly Trp Arg Gln Trp Ile Pro Ala Gly Ile 
                645                 650                 655     


Gly Val Thr Gly Val Ile Ile Ala Val Ile Ala Leu Phe Cys Ile Cys 
            660                 665                 670         


Lys Phe Val Phe 
        675     


<210>  180
<211>  372
<212>  PRT
<213>  Sudan ebolavirus

<400>  180

Met Glu Gly Leu Ser Leu Leu Gln Leu Pro Arg Asp Lys Phe Arg Lys 
1               5                   10                  15      


Ser Ser Phe Phe Val Trp Val Ile Ile Leu Phe Gln Lys Ala Phe Ser 
            20                  25                  30          


Met Pro Leu Gly Val Val Thr Asn Ser Thr Leu Glu Val Thr Glu Ile 
        35                  40                  45              


Asp Gln Leu Val Cys Lys Asp His Leu Ala Ser Thr Asp Gln Leu Lys 
    50                  55                  60                  


Ser Val Gly Leu Asn Leu Glu Gly Ser Gly Val Ser Thr Asp Ile Pro 
65                  70                  75                  80  


Ser Ala Thr Lys Arg Trp Gly Phe Arg Ser Gly Val Pro Pro Gln Val 
                85                  90                  95      


Val Ser Tyr Glu Ala Gly Glu Trp Ala Glu Asn Cys Tyr Asn Leu Glu 
            100                 105                 110         


Ile Lys Lys Pro Asp Gly Ser Glu Cys Leu Pro Pro Pro Pro Asp Gly 
        115                 120                 125             


Val Arg Gly Phe Pro Arg Cys Arg Tyr Val His Lys Ala Gln Gly Thr 
    130                 135                 140                 


Gly Pro Cys Pro Gly Asp Tyr Ala Phe His Lys Asp Gly Ala Phe Phe 
145                 150                 155                 160 


Leu Tyr Asp Arg Leu Ala Ser Thr Val Ile Tyr Arg Gly Val Asn Phe 
                165                 170                 175     


Ala Glu Gly Val Ile Ala Phe Leu Ile Leu Ala Lys Pro Lys Glu Thr 
            180                 185                 190         


Phe Leu Gln Ser Pro Pro Ile Arg Glu Ala Ala Asn Tyr Thr Glu Asn 
        195                 200                 205             


Thr Ser Ser Tyr Tyr Ala Thr Ser Tyr Leu Glu Tyr Glu Ile Glu Asn 
    210                 215                 220                 


Phe Gly Ala Gln His Ser Thr Thr Leu Phe Lys Ile Asn Asn Asn Thr 
225                 230                 235                 240 


Phe Val Leu Leu Asp Arg Pro His Thr Pro Gln Phe Leu Phe Gln Leu 
                245                 250                 255     


Asn Asp Thr Ile Gln Leu His Gln Gln Leu Ser Asn Thr Thr Gly Lys 
            260                 265                 270         


Leu Ile Trp Thr Leu Asp Ala Asn Ile Asn Ala Asp Ile Gly Glu Trp 
        275                 280                 285             


Ala Phe Trp Glu Asn Lys Lys Ile Ser Pro Asn Asn Tyr Val Glu Lys 
    290                 295                 300                 


Ser Cys Leu Ser Lys Leu Tyr Arg Ser Thr Arg Gln Lys Thr Met Met 
305                 310                 315                 320 


Arg His Arg Arg Glu Leu Gln Arg Glu Glu Ser Pro Thr Gly Pro Pro 
                325                 330                 335     


Gly Ser Ile Arg Thr Trp Phe Gln Arg Ile Pro Leu Gly Trp Phe His 
            340                 345                 350         


Cys Thr Tyr Gln Lys Gly Lys Gln His Cys Arg Leu Arg Ile Arg Gln 
        355                 360                 365             


Lys Val Glu Glu 
    370         


<210>  181
<211>  365
<212>  PRT
<213>  Tai Forest ebolavirus

<400>  181

Met Gly Ala Ser Gly Ile Leu Gln Leu Pro Arg Glu Arg Phe Arg Lys 
1               5                   10                  15      


Thr Ser Phe Phe Val Trp Val Ile Ile Leu Phe His Lys Val Phe Ser 
            20                  25                  30          


Ile Pro Leu Gly Val Val His Asn Asn Thr Leu Gln Val Ser Asp Ile 
        35                  40                  45              


Asp Lys Phe Val Cys Arg Asp Lys Leu Ser Ser Thr Ser Gln Leu Lys 
    50                  55                  60                  


Ser Val Gly Leu Asn Leu Glu Gly Asn Gly Val Ala Thr Asp Val Pro 
65                  70                  75                  80  


Thr Ala Thr Lys Arg Trp Gly Phe Arg Ala Gly Val Pro Pro Lys Val 
                85                  90                  95      


Val Asn Tyr Glu Ala Gly Glu Trp Ala Glu Asn Cys Tyr Asn Leu Ala 
            100                 105                 110         


Ile Lys Lys Val Asp Gly Ser Glu Cys Leu Pro Glu Ala Pro Glu Gly 
        115                 120                 125             


Val Arg Asp Phe Pro Arg Cys Arg Tyr Val His Lys Val Ser Gly Thr 
    130                 135                 140                 


Gly Pro Cys Pro Gly Gly Leu Ala Phe His Lys Glu Gly Ala Phe Phe 
145                 150                 155                 160 


Leu Tyr Asp Arg Leu Ala Ser Thr Ile Ile Tyr Arg Gly Thr Thr Phe 
                165                 170                 175     


Ala Glu Gly Val Ile Ala Phe Leu Ile Leu Pro Lys Ala Arg Lys Asp 
            180                 185                 190         


Phe Phe Gln Ser Pro Pro Leu His Glu Pro Ala Asn Met Thr Thr Asp 
        195                 200                 205             


Pro Ser Ser Tyr Tyr His Thr Thr Thr Ile Asn Tyr Val Val Asp Asn 
    210                 215                 220                 


Phe Gly Thr Asn Thr Thr Glu Phe Leu Phe Gln Val Asp His Leu Thr 
225                 230                 235                 240 


Tyr Val Gln Leu Glu Ala Arg Phe Thr Pro Gln Phe Leu Val Leu Leu 
                245                 250                 255     


Asn Glu Thr Ile Tyr Ser Asp Asn Arg Arg Ser Asn Thr Thr Gly Lys 
            260                 265                 270         


Leu Ile Trp Lys Ile Asn Pro Thr Val Asp Thr Ser Met Gly Glu Trp 
        275                 280                 285             


Ala Phe Trp Glu Asn Lys Lys Thr Ser Gln Lys Pro Phe Gln Val Lys 
    290                 295                 300                 


Ser Cys Leu Ser Tyr Leu Tyr Gln Lys Pro Arg Thr Arg Ser Leu Thr 
305                 310                 315                 320 


Arg Gln Arg Arg Ser Leu Leu Pro Ser Pro Pro Thr Thr Thr Gln Ala 
                325                 330                 335     


Lys Thr Thr Lys Asn Trp Phe Gln Arg Ile Pro Leu Gln Trp Phe Arg 
            340                 345                 350         


Cys Lys Thr Ser Arg Glu Arg Thr Gln Cys Gln Pro Gln 
        355                 360                 365 


<210>  182
<211>  677
<212>  PRT
<213>  Reston ebolavirus

<400>  182

Met Gly Ser Gly Tyr Gln Leu Leu Gln Leu Pro Arg Glu Arg Phe Arg 
1               5                   10                  15      


Lys Thr Ser Phe Leu Val Trp Val Ile Ile Leu Phe Gln Arg Ala Ile 
            20                  25                  30          


Ser Met Pro Leu Gly Ile Val Thr Asn Ser Thr Leu Lys Ala Thr Glu 
        35                  40                  45              


Ile Asp Gln Leu Val Cys Arg Asp Lys Leu Ser Ser Thr Ser Gln Leu 
    50                  55                  60                  


Lys Ser Val Gly Leu Asn Leu Glu Gly Asn Gly Ile Ala Thr Asp Val 
65                  70                  75                  80  


Pro Ser Ala Thr Lys Arg Trp Gly Phe Arg Ser Gly Val Pro Pro Lys 
                85                  90                  95      


Val Val Ser Tyr Glu Ala Gly Glu Trp Ala Glu Asn Cys Tyr Asn Leu 
            100                 105                 110         


Glu Ile Lys Lys Ser Asp Gly Ser Glu Cys Leu Pro Leu Pro Pro Asp 
        115                 120                 125             


Gly Val Arg Gly Phe Pro Arg Cys Arg Tyr Val His Lys Val Gln Gly 
    130                 135                 140                 


Thr Gly Pro Cys Pro Gly Asp Leu Ala Phe His Lys Asn Gly Ala Phe 
145                 150                 155                 160 


Phe Leu Tyr Asp Arg Leu Ala Ser Thr Val Ile Tyr Arg Gly Thr Thr 
                165                 170                 175     


Phe Ala Glu Gly Val Ile Ala Phe Leu Ile Leu Ser Glu Pro Lys Lys 
            180                 185                 190         


His Phe Trp Lys Ala Thr Pro Ala His Glu Pro Val Asn Thr Thr Asp 
        195                 200                 205             


Asp Ser Thr Ser Tyr Tyr Met Thr Leu Thr Leu Ser Tyr Glu Met Ser 
    210                 215                 220                 


Asn Phe Gly Gly Glu Glu Ser Asn Thr Leu Phe Lys Val Asp Asn His 
225                 230                 235                 240 


Thr Tyr Val Gln Leu Asp Arg Pro His Thr Pro Gln Phe Leu Val Gln 
                245                 250                 255     


Leu Asn Glu Thr Leu Arg Arg Asn Asn Arg Leu Ser Asn Ser Thr Gly 
            260                 265                 270         


Arg Leu Thr Trp Thr Val Asp Pro Lys Ile Glu Pro Asp Val Gly Glu 
        275                 280                 285             


Trp Ala Phe Trp Glu Thr Lys Lys Asn Phe Ser Gln Gln Leu His Gly 
    290                 295                 300                 


Glu Asn Leu His Phe Gln Ile Leu Ser Thr His Thr Asn Asn Ser Ser 
305                 310                 315                 320 


Asp Gln Ser Pro Ala Gly Thr Val Gln Gly Lys Ile Ser Tyr His Pro 
                325                 330                 335     


Pro Thr Asn Asn Ser Glu Leu Val Pro Thr Asp Ser Pro Pro Val Val 
            340                 345                 350         


Ser Val Leu Thr Ala Gly Arg Thr Glu Glu Met Ser Thr Gln Gly Leu 
        355                 360                 365             


Thr Asn Gly Glu Thr Ile Thr Gly Phe Thr Ala Asn Pro Met Thr Thr 
    370                 375                 380                 


Thr Ile Ala Pro Ser Pro Thr Met Thr Ser Glu Val Asp Asn Asn Val 
385                 390                 395                 400 


Pro Ser Glu Gln Pro Asn Asn Thr Ala Ser Ile Glu Asp Ser Pro Pro 
                405                 410                 415     


Ser Ala Ser Asn Glu Thr Ile Asp His Ser Glu Met Asn Ser Ile Gln 
            420                 425                 430         


Gly Ser Asn Asn Ser Ala Gln Ser Pro Gln Thr Lys Ala Thr Pro Ala 
        435                 440                 445             


Pro Thr Ala Ser Pro Met Thr Leu Asp Pro Gln Glu Thr Ala Asn Ile 
    450                 455                 460                 


Ser Lys Pro Gly Thr Ser Pro Gly Ser Ala Ala Gly Pro Ser Gln Pro 
465                 470                 475                 480 


Gly Leu Thr Ile Asn Thr Ile Ser Lys Val Ala Asp Ser Leu Ser Pro 
                485                 490                 495     


Thr Arg Lys Gln Lys Arg Ser Val Arg Gln Asn Thr Ala Asn Lys Cys 
            500                 505                 510         


Asn Pro Asp Leu His Tyr Trp Thr Ala Val Asp Glu Gly Ala Ala Ala 
        515                 520                 525             


Gly Leu Ala Trp Ile Pro Tyr Phe Gly Pro Ala Ala Glu Gly Ile Tyr 
    530                 535                 540                 


Ile Glu Gly Val Met His Asn Gln Asn Gly Leu Ile Cys Gly Leu Arg 
545                 550                 555                 560 


Gln Leu Ala Asn Glu Thr Thr Gln Ala Leu Gln Leu Phe Leu Arg Ala 
                565                 570                 575     


Thr Thr Glu Leu Arg Thr Tyr Ser Leu Leu Asn Arg Lys Ala Ile Asp 
            580                 585                 590         


Phe Leu Leu Gln Arg Trp Gly Gly Thr Cys Arg Ile Leu Gly Pro Ser 
        595                 600                 605             


Cys Cys Ile Glu Pro His Asp Trp Thr Lys Asn Ile Thr Asp Glu Ile 
    610                 615                 620                 


Asn Gln Ile Lys His Asp Phe Ile Asp Asn Pro Leu Pro Asp His Gly 
625                 630                 635                 640 


Asp Asp Leu Asn Leu Trp Thr Gly Trp Arg Gln Trp Ile Pro Ala Gly 
                645                 650                 655     


Ile Gly Ile Ile Gly Val Ile Ile Ala Ile Ile Ala Leu Leu Cys Ile 
            660                 665                 670         


Cys Lys Ile Leu Cys 
        675         


<210>  183
<211>  681
<212>  PRT
<213>  Lake Victoria marburgvirus

<400>  183

Met Lys Thr Thr Cys Leu Leu Ile Ser Leu Ile Leu Ile Gln Gly Val 
1               5                   10                  15      


Lys Thr Leu Pro Ile Leu Glu Ile Ala Ser Asn Ile Gln Pro Gln Asn 
            20                  25                  30          


Val Asp Ser Val Cys Ser Gly Thr Leu Gln Lys Thr Glu Asp Val His 
        35                  40                  45              


Leu Met Gly Phe Thr Leu Ser Gly Gln Lys Val Ala Asp Ser Pro Leu 
    50                  55                  60                  


Glu Ala Ser Lys Arg Trp Ala Phe Arg Ala Gly Val Pro Pro Lys Asn 
65                  70                  75                  80  


Val Glu Tyr Thr Glu Gly Glu Glu Ala Lys Thr Cys Tyr Asn Ile Ser 
                85                  90                  95      


Val Thr Asp Pro Ser Gly Lys Ser Leu Leu Leu Asp Pro Pro Thr Asn 
            100                 105                 110         


Ile Arg Asp Tyr Pro Lys Cys Lys Thr Ile His His Ile Gln Gly Gln 
        115                 120                 125             


Asn Pro His Ala Gln Gly Ile Ala Leu His Leu Trp Gly Ala Phe Phe 
    130                 135                 140                 


Leu Tyr Asp Arg Ile Ala Ser Thr Thr Met Tyr Arg Gly Lys Val Phe 
145                 150                 155                 160 


Thr Glu Gly Asn Ile Ala Ala Met Ile Val Asn Lys Thr Val His Lys 
                165                 170                 175     


Met Ile Phe Ser Arg Gln Gly Gln Gly Tyr Arg His Met Asn Leu Thr 
            180                 185                 190         


Ser Thr Asn Lys Tyr Trp Thr Ser Ser Asn Gly Thr Gln Thr Asn Asp 
        195                 200                 205             


Thr Gly Cys Phe Gly Thr Leu Gln Glu Tyr Asn Ser Thr Lys Asn Gln 
    210                 215                 220                 


Thr Cys Ala Pro Ser Lys Lys Pro Leu Pro Leu Pro Thr Ala His Pro 
225                 230                 235                 240 


Glu Val Lys Leu Thr Ser Thr Ser Thr Asp Ala Thr Lys Leu Asn Thr 
                245                 250                 255     


Thr Asp Pro Asn Ser Asp Asp Glu Asp Leu Thr Thr Ser Gly Ser Gly 
            260                 265                 270         


Ser Gly Glu Gln Glu Pro Tyr Thr Thr Ser Asp Ala Ala Thr Lys Gln 
        275                 280                 285             


Gly Leu Ser Ser Thr Met Pro Pro Thr Pro Ser Pro Gln Pro Ser Thr 
    290                 295                 300                 


Pro Gln Gln Gly Gly Asn Asn Thr Asn His Ser Gln Gly Val Val Thr 
305                 310                 315                 320 


Glu Pro Gly Lys Thr Asn Thr Thr Ala Gln Pro Ser Met Pro Pro His 
                325                 330                 335     


Asn Thr Thr Thr Ile Ser Thr Asn Asn Thr Ser Lys His Asn Leu Ser 
            340                 345                 350         


Thr Pro Ser Val Pro Ile Gln Asn Ala Thr Asn Tyr Asn Thr Gln Ser 
        355                 360                 365             


Thr Ala Pro Glu Asn Glu Gln Thr Ser Ala Pro Ser Lys Thr Thr Leu 
    370                 375                 380                 


Leu Pro Thr Glu Asn Pro Thr Thr Ala Lys Ser Thr Asn Ser Thr Lys 
385                 390                 395                 400 


Ser Pro Thr Thr Thr Val Pro Asn Thr Thr Asn Lys Tyr Ser Thr Ser 
                405                 410                 415     


Pro Ser Pro Thr Pro Asn Ser Thr Ala Gln His Leu Val Tyr Phe Arg 
            420                 425                 430         


Arg Lys Arg Asn Ile Leu Trp Arg Glu Gly Asp Met Phe Pro Phe Leu 
        435                 440                 445             


Asp Gly Leu Ile Asn Ala Pro Ile Asp Phe Asp Pro Val Pro Asn Thr 
    450                 455                 460                 


Lys Thr Ile Phe Asp Glu Ser Ser Ser Ser Gly Ala Ser Ala Glu Glu 
465                 470                 475                 480 


Asp Gln His Ala Ser Pro Asn Ile Ser Leu Thr Leu Ser Tyr Phe Pro 
                485                 490                 495     


Lys Val Asn Glu Asn Thr Ala His Ser Gly Glu Asn Glu Asn Asp Cys 
            500                 505                 510         


Asp Ala Glu Leu Arg Ile Trp Ser Val Gln Glu Asp Asp Leu Ala Ala 
        515                 520                 525             


Gly Leu Ser Trp Ile Pro Phe Phe Gly Pro Gly Ile Glu Gly Leu Tyr 
    530                 535                 540                 


Thr Ala Gly Leu Ile Lys Asn Gln Asn Asn Leu Val Cys Arg Leu Arg 
545                 550                 555                 560 


Arg Leu Ala Asn Gln Thr Ala Lys Ser Leu Glu Leu Leu Leu Arg Val 
                565                 570                 575     


Thr Thr Glu Glu Arg Thr Phe Ser Leu Ile Asn Arg His Ala Ile Asp 
            580                 585                 590         


Phe Leu Leu Ala Arg Trp Gly Gly Thr Cys Lys Val Leu Gly Pro Asp 
        595                 600                 605             


Cys Cys Ile Gly Ile Glu Asp Leu Ser Arg Asn Ile Ser Glu Gln Ile 
    610                 615                 620                 


Asp Gln Ile Lys Lys Asp Glu Gln Lys Glu Gly Thr Gly Trp Gly Leu 
625                 630                 635                 640 


Gly Gly Lys Trp Trp Thr Ser Asp Trp Gly Val Leu Thr Asn Leu Gly 
                645                 650                 655     


Ile Leu Leu Leu Leu Ser Ile Ala Val Leu Ile Ala Leu Ser Cys Ile 
            660                 665                 670         


Cys Arg Ile Phe Thr Lys Tyr Ile Gly 
        675                 680     


<210>  184
<211>  676
<212>  PRT
<213>  Zaire ebolavirus

<400>  184

Met Gly Val Thr Gly Ile Leu Gln Leu Pro Arg Asp Arg Phe Lys Arg 
1               5                   10                  15      


Thr Ser Phe Phe Leu Trp Val Ile Ile Leu Phe Gln Arg Thr Phe Ser 
            20                  25                  30          


Ile Pro Leu Gly Val Ile His Asn Ser Thr Leu Gln Val Asn Asp Val 
        35                  40                  45              


Asp Lys Leu Val Cys Arg Asp Lys Leu Ser Ser Thr Asn Gln Leu Arg 
    50                  55                  60                  


Ser Val Gly Leu Asn Leu Glu Gly Asn Gly Val Ala Thr Asp Val Pro 
65                  70                  75                  80  


Ser Ala Thr Lys Arg Trp Gly Phe Arg Ser Gly Val Pro Pro Lys Val 
                85                  90                  95      


Val Asn Tyr Glu Ala Gly Glu Trp Ala Glu Asn Cys Tyr Asn Leu Glu 
            100                 105                 110         


Ile Lys Lys Pro Asp Gly Ser Glu Cys Leu Pro Ala Ala Pro Asp Gly 
        115                 120                 125             


Ile Arg Gly Phe Pro Arg Cys Arg Tyr Val His Lys Val Ser Gly Thr 
    130                 135                 140                 


Gly Pro Cys Ala Gly Asp Phe Ala Phe His Lys Glu Gly Ala Phe Phe 
145                 150                 155                 160 


Leu Tyr Asp Arg Leu Ala Ser Thr Val Ile Tyr Arg Gly Thr Thr Phe 
                165                 170                 175     


Ala Glu Gly Val Val Ala Phe Leu Ile Leu Pro Gln Ala Lys Lys Asp 
            180                 185                 190         


Phe Phe Ser Ser His Pro Leu Arg Glu Pro Val Asn Ala Thr Glu Asp 
        195                 200                 205             


Pro Ser Ser Gly Tyr Tyr Ser Thr Thr Ile Arg Tyr Gln Ala Thr Gly 
    210                 215                 220                 


Phe Gly Thr Asn Glu Thr Glu Tyr Leu Phe Glu Val Asp Asn Leu Thr 
225                 230                 235                 240 


Tyr Val Gln Leu Glu Ser Arg Phe Thr Pro Gln Phe Leu Leu Gln Leu 
                245                 250                 255     


Asn Glu Thr Ile Tyr Thr Ser Gly Lys Arg Ser Asn Thr Thr Gly Lys 
            260                 265                 270         


Leu Ile Trp Lys Val Asn Pro Glu Ile Asp Thr Thr Ile Gly Glu Trp 
        275                 280                 285             


Ala Phe Trp Glu Thr Lys Lys Asn Leu Thr Arg Lys Ile Arg Ser Glu 
    290                 295                 300                 


Glu Leu Ser Phe Thr Val Val Ser Asn Gly Ala Lys Asn Ile Ser Gly 
305                 310                 315                 320 


Gln Ser Pro Ala Arg Thr Ser Ser Asp Pro Gly Thr Asn Thr Thr Thr 
                325                 330                 335     


Glu Asp His Lys Ile Met Ala Ser Glu Asn Ser Ser Ala Met Val Gln 
            340                 345                 350         


Val His Ser Gln Gly Arg Glu Ala Ala Val Ser His Leu Thr Thr Leu 
        355                 360                 365             


Ala Thr Ile Ser Thr Ser Pro Gln Ser Leu Thr Thr Lys Pro Gly Pro 
    370                 375                 380                 


Asp Asn Ser Thr His Asn Thr Pro Val Tyr Lys Leu Asp Ile Ser Glu 
385                 390                 395                 400 


Ala Thr Gln Val Glu Gln His His Arg Arg Thr Asp Asn Asp Ser Thr 
                405                 410                 415     


Ala Ser Asp Thr Pro Ser Ala Thr Thr Ala Ala Gly Pro Pro Lys Ala 
            420                 425                 430         


Glu Asn Thr Asn Thr Ser Lys Ser Thr Asp Phe Leu Asp Pro Ala Thr 
        435                 440                 445             


Thr Thr Ser Pro Gln Asn His Ser Glu Thr Ala Gly Asn Asn Asn Thr 
    450                 455                 460                 


His His Gln Asp Thr Gly Glu Glu Ser Ala Ser Ser Gly Lys Leu Gly 
465                 470                 475                 480 


Leu Ile Thr Asn Thr Ile Ala Gly Val Ala Gly Leu Ile Thr Gly Gly 
                485                 490                 495     


Arg Arg Thr Arg Arg Glu Ala Ile Val Asn Ala Gln Pro Lys Cys Asn 
            500                 505                 510         


Pro Asn Leu His Tyr Trp Thr Thr Gln Asp Glu Gly Ala Ala Ile Gly 
        515                 520                 525             


Leu Ala Trp Ile Pro Tyr Phe Gly Pro Ala Ala Glu Gly Ile Tyr Thr 
    530                 535                 540                 


Glu Gly Leu Met His Asn Gln Asn Gly Leu Ile Cys Gly Leu Arg Gln 
545                 550                 555                 560 


Leu Ala Asn Glu Thr Thr Gln Ala Leu Gln Leu Phe Leu Arg Ala Thr 
                565                 570                 575     


Thr Glu Leu Arg Thr Phe Ser Ile Leu Asn Arg Lys Ala Ile Asp Phe 
            580                 585                 590         


Leu Leu Gln Arg Trp Gly Gly Thr Cys His Ile Leu Gly Pro Asp Cys 
        595                 600                 605             


Cys Ile Glu Pro His Asp Trp Thr Lys Asn Ile Thr Asp Lys Ile Asp 
    610                 615                 620                 


Gln Ile Ile His Asp Phe Val Asp Lys Thr Leu Pro Asp Gln Gly Asp 
625                 630                 635                 640 


Asn Asp Asn Trp Trp Thr Gly Trp Arg Gln Trp Ile Pro Ala Gly Ile 
                645                 650                 655     


Gly Val Thr Gly Val Ile Ile Ala Val Ile Ala Leu Phe Cys Ile Cys 
            660                 665                 670         


Lys Phe Val Phe 
        675     


<210>  185
<211>  677
<212>  PRT
<213>  Reston ebolavirus

<400>  185

Met Gly Ser Gly Tyr Gln Leu Leu Gln Leu Pro Arg Glu Arg Phe Arg 
1               5                   10                  15      


Lys Thr Ser Phe Leu Val Trp Val Ile Ile Leu Phe Gln Arg Ala Ile 
            20                  25                  30          


Ser Met Pro Leu Gly Ile Val Thr Asn Ser Thr Leu Lys Ala Thr Glu 
        35                  40                  45              


Ile Asp Gln Leu Val Cys Arg Asp Lys Leu Ser Ser Thr Ser Gln Leu 
    50                  55                  60                  


Lys Ser Val Gly Leu Asn Leu Glu Gly Asn Gly Ile Ala Thr Asp Val 
65                  70                  75                  80  


Pro Ser Ala Thr Lys Arg Trp Gly Phe Arg Ser Gly Val Pro Pro Lys 
                85                  90                  95      


Val Val Ser Tyr Glu Ala Gly Glu Trp Ala Glu Asn Cys Tyr Asn Leu 
            100                 105                 110         


Glu Ile Lys Lys Ser Asp Gly Ser Glu Cys Leu Pro Leu Pro Pro Asp 
        115                 120                 125             


Gly Val Arg Gly Phe Pro Arg Cys Arg Tyr Val His Lys Val Gln Gly 
    130                 135                 140                 


Thr Gly Pro Cys Pro Gly Asp Leu Ala Phe His Lys Asn Gly Ala Phe 
145                 150                 155                 160 


Phe Leu Tyr Asp Arg Leu Ala Ser Thr Val Ile Tyr Arg Gly Thr Thr 
                165                 170                 175     


Phe Ala Glu Gly Val Val Ala Phe Leu Ile Leu Ser Glu Pro Lys Lys 
            180                 185                 190         


His Phe Trp Lys Ala Thr Pro Ala His Glu Pro Val Asn Thr Thr Asp 
        195                 200                 205             


Asp Ser Thr Ser Tyr Tyr Met Thr Leu Thr Leu Ser Tyr Glu Met Ser 
    210                 215                 220                 


Asn Phe Gly Gly Asn Glu Ser Asn Thr Leu Phe Lys Val Asp Asn His 
225                 230                 235                 240 


Thr Tyr Val Gln Leu Asp Arg Pro His Thr Pro Gln Phe Leu Val Gln 
                245                 250                 255     


Leu Asn Glu Thr Leu Arg Arg Asn Asn Arg Leu Ser Asn Ser Thr Gly 
            260                 265                 270         


Arg Leu Thr Trp Thr Leu Asp Pro Lys Ile Glu Pro Asp Val Gly Glu 
        275                 280                 285             


Trp Ala Phe Trp Glu Thr Lys Lys Asn Phe Ser Gln Gln Leu His Gly 
    290                 295                 300                 


Glu Asn Leu His Phe Gln Ile Leu Ser Thr His Thr Asn Asn Ser Ser 
305                 310                 315                 320 


Asp Gln Ser Pro Ala Gly Thr Val Gln Gly Lys Ile Ser Tyr His Pro 
                325                 330                 335     


Pro Ala Asn Asn Ser Glu Leu Val Pro Thr Asp Ser Pro Pro Val Val 
            340                 345                 350         


Ser Val Leu Thr Ala Gly Arg Thr Glu Glu Met Ser Thr Gln Gly Leu 
        355                 360                 365             


Thr Asn Gly Glu Thr Ile Thr Gly Phe Thr Ala Asn Pro Met Thr Thr 
    370                 375                 380                 


Thr Ile Ala Pro Ser Pro Thr Met Thr Ser Glu Val Asp Asn Asn Val 
385                 390                 395                 400 


Pro Ser Glu Gln Pro Asn Asn Thr Ala Ser Ile Glu Asp Ser Pro Pro 
                405                 410                 415     


Ser Ala Ser Asn Glu Thr Ile Tyr His Ser Glu Met Asp Pro Ile Gln 
            420                 425                 430         


Gly Ser Asn Asn Ser Ala Gln Ser Pro Gln Thr Lys Thr Thr Pro Ala 
        435                 440                 445             


Pro Thr Thr Ser Pro Met Thr Gln Asp Pro Gln Glu Thr Ala Asn Ser 
    450                 455                 460                 


Ser Lys Pro Gly Thr Ser Pro Gly Ser Ala Ala Gly Pro Ser Gln Pro 
465                 470                 475                 480 


Gly Leu Thr Ile Asn Thr Val Ser Lys Val Ala Asp Ser Leu Ser Pro 
                485                 490                 495     


Thr Arg Lys Gln Lys Arg Ser Val Arg Gln Asn Thr Ala Asn Lys Cys 
            500                 505                 510         


Asn Pro Asp Leu Tyr Tyr Trp Thr Ala Val Asp Glu Gly Ala Ala Val 
        515                 520                 525             


Gly Leu Ala Trp Ile Pro Tyr Phe Gly Pro Ala Ala Glu Gly Ile Tyr 
    530                 535                 540                 


Ile Glu Gly Val Met His Asn Gln Asn Gly Leu Ile Cys Gly Leu Arg 
545                 550                 555                 560 


Gln Leu Ala Asn Glu Thr Thr Gln Ala Leu Gln Leu Phe Leu Arg Ala 
                565                 570                 575     


Thr Thr Glu Leu Arg Thr Tyr Ser Leu Leu Asn Arg Lys Ala Ile Asp 
            580                 585                 590         


Phe Leu Leu Gln Arg Trp Gly Gly Thr Cys Arg Ile Leu Gly Pro Ser 
        595                 600                 605             


Cys Cys Ile Glu Pro His Asp Trp Thr Lys Asn Ile Thr Asp Glu Ile 
    610                 615                 620                 


Asn Gln Ile Lys His Asp Phe Ile Asp Asn Pro Leu Pro Asp His Gly 
625                 630                 635                 640 


Asp Asp Leu Asn Leu Trp Thr Gly Trp Arg Gln Trp Ile Pro Ala Gly 
                645                 650                 655     


Ile Gly Ile Ile Gly Val Ile Ile Ala Ile Ile Ala Leu Leu Cys Ile 
            660                 665                 670         


Cys Lys Ile Leu Cys 
        675         


<210>  186
<211>  676
<212>  PRT
<213>  Tai Forest ebolavirus

<400>  186

Met Gly Ala Ser Gly Ile Leu Gln Leu Pro Arg Glu Arg Phe Arg Lys 
1               5                   10                  15      


Thr Ser Phe Phe Val Trp Val Ile Ile Leu Phe His Lys Val Phe Ser 
            20                  25                  30          


Ile Pro Leu Gly Val Val His Asn Asn Thr Leu Gln Val Ser Asp Ile 
        35                  40                  45              


Asp Lys Phe Val Cys Arg Asp Lys Leu Ser Ser Thr Ser Gln Leu Lys 
    50                  55                  60                  


Ser Val Gly Leu Asn Leu Glu Gly Asn Gly Val Ala Thr Asp Val Pro 
65                  70                  75                  80  


Thr Ala Thr Lys Arg Trp Gly Phe Arg Ala Gly Val Pro Pro Lys Val 
                85                  90                  95      


Val Asn Tyr Glu Ala Gly Glu Trp Ala Glu Asn Cys Tyr Asn Leu Ala 
            100                 105                 110         


Ile Lys Lys Val Asp Gly Ser Glu Cys Leu Pro Glu Ala Pro Glu Gly 
        115                 120                 125             


Val Arg Asp Phe Pro Arg Cys Arg Tyr Val His Lys Val Ser Gly Thr 
    130                 135                 140                 


Gly Pro Cys Pro Gly Gly Leu Ala Phe His Lys Glu Gly Ala Phe Phe 
145                 150                 155                 160 


Leu Tyr Asp Arg Leu Ala Ser Thr Ile Ile Tyr Arg Gly Thr Thr Phe 
                165                 170                 175     


Ala Glu Gly Val Ile Ala Phe Leu Ile Leu Pro Lys Ala Arg Lys Asp 
            180                 185                 190         


Phe Phe Gln Ser Pro Pro Leu His Glu Pro Ala Asn Met Thr Thr Asp 
        195                 200                 205             


Pro Ser Ser Tyr Tyr His Thr Thr Thr Ile Asn Tyr Val Val Asp Asn 
    210                 215                 220                 


Phe Gly Thr Asn Thr Thr Glu Phe Leu Phe Gln Val Asp His Leu Thr 
225                 230                 235                 240 


Tyr Val Gln Leu Glu Ala Arg Phe Thr Pro Gln Phe Leu Val Leu Leu 
                245                 250                 255     


Asn Glu Thr Ile Tyr Ser Asp Asn Arg Arg Ser Asn Thr Thr Gly Lys 
            260                 265                 270         


Leu Ile Trp Lys Ile Asn Pro Thr Val Asp Thr Ser Met Gly Glu Trp 
        275                 280                 285             


Ala Phe Trp Glu Asn Lys Lys Asn Phe Thr Lys Thr Leu Ser Ser Glu 
    290                 295                 300                 


Glu Leu Ser Phe Val Pro Val Pro Glu Thr Gln Asn Gln Val Leu Asp 
305                 310                 315                 320 


Thr Thr Ala Thr Val Ser Pro Pro Ile Ser Ala His Asn His Ala Gly 
                325                 330                 335     


Glu Asp His Lys Glu Leu Val Ser Glu Asp Ser Thr Pro Val Val Gln 
            340                 345                 350         


Met Gln Asn Ile Lys Gly Lys Asp Thr Met Pro Thr Thr Val Thr Gly 
        355                 360                 365             


Val Pro Thr Thr Thr Pro Ser Pro Phe Pro Ile Asn Ala Arg Asn Thr 
    370                 375                 380                 


Asp His Thr Lys Ser Phe Ile Gly Leu Glu Gly Pro Gln Glu Asp His 
385                 390                 395                 400 


Ser Thr Thr Gln Pro Ala Lys Thr Thr Ser Gln Pro Thr Asn Ser Thr 
                405                 410                 415     


Glu Ser Thr Thr Leu Asn Pro Thr Ser Glu Pro Ser Ser Arg Gly Thr 
            420                 425                 430         


Gly Pro Ser Ser Pro Thr Val Pro Asn Thr Thr Glu Ser His Ala Glu 
        435                 440                 445             


Leu Gly Lys Thr Thr Pro Thr Thr Leu Pro Glu Gln His Thr Ala Ala 
    450                 455                 460                 


Ser Ala Ile Pro Arg Ala Val His Pro Asp Glu Leu Ser Gly Pro Gly 
465                 470                 475                 480 


Phe Leu Thr Asn Thr Ile Arg Gly Val Thr Asn Leu Leu Thr Gly Ser 
                485                 490                 495     


Arg Arg Lys Arg Arg Asp Val Thr Pro Asn Thr Gln Pro Lys Cys Asn 
            500                 505                 510         


Pro Asn Leu His Tyr Trp Thr Ala Leu Asp Glu Gly Ala Ala Ile Gly 
        515                 520                 525             


Leu Ala Trp Ile Pro Tyr Phe Gly Pro Ala Ala Glu Gly Ile Tyr Thr 
    530                 535                 540                 


Glu Gly Ile Met Glu Asn Gln Asn Gly Leu Ile Cys Gly Leu Arg Gln 
545                 550                 555                 560 


Leu Ala Asn Glu Thr Thr Gln Ala Leu Gln Leu Phe Leu Arg Ala Thr 
                565                 570                 575     


Thr Glu Leu Arg Thr Phe Ser Ile Leu Asn Arg Lys Ala Ile Asp Phe 
            580                 585                 590         


Leu Leu Gln Arg Trp Gly Gly Thr Cys His Ile Leu Gly Pro Asp Cys 
        595                 600                 605             


Cys Ile Glu Pro Gln Asp Trp Thr Lys Asn Ile Thr Asp Lys Ile Asp 
    610                 615                 620                 


Gln Ile Ile His Asp Phe Val Asp Asn Asn Leu Pro Asn Gln Asn Asp 
625                 630                 635                 640 


Gly Ser Asn Trp Trp Thr Gly Trp Lys Gln Trp Val Pro Ala Gly Ile 
                645                 650                 655     


Gly Ile Thr Gly Val Ile Ile Ala Ile Ile Ala Leu Leu Cys Ile Cys 
            660                 665                 670         


Lys Phe Met Leu 
        675     


<210>  187
<211>  681
<212>  PRT
<213>  Lake Victoria marburgvirus

<400>  187

Met Arg Thr Thr Cys Leu Phe Ile Ser Leu Ile Leu Ile Gln Gly Ile 
1               5                   10                  15      


Lys Thr Leu Pro Ile Leu Glu Ile Ala Ser Asn Asp Gln Pro Gln Asn 
            20                  25                  30          


Val Asp Ser Val Cys Ser Gly Thr Leu Gln Lys Thr Glu Asp Val His 
        35                  40                  45              


Leu Met Gly Phe Thr Leu Ser Gly Gln Lys Val Ala Asp Ser Pro Leu 
    50                  55                  60                  


Glu Ala Ser Lys Arg Trp Ala Phe Arg Thr Gly Val Pro Pro Lys Asn 
65                  70                  75                  80  


Val Glu Tyr Thr Glu Gly Glu Glu Ala Lys Thr Cys Tyr Asn Ile Ser 
                85                  90                  95      


Val Thr Asp Pro Ser Gly Lys Ser Leu Leu Leu Asp Pro Pro Thr Asn 
            100                 105                 110         


Val Arg Asp Tyr Pro Lys Cys Lys Thr Ile His His Ile Gln Gly Gln 
        115                 120                 125             


Asn Pro His Ala Gln Gly Ile Ala Leu His Leu Trp Gly Ala Phe Phe 
    130                 135                 140                 


Leu Tyr Asp Arg Ile Ala Ser Thr Thr Met Tyr Arg Gly Lys Val Phe 
145                 150                 155                 160 


Thr Glu Gly Asn Ile Ala Ala Met Ile Val Asn Lys Thr Val His Lys 
                165                 170                 175     


Met Ile Phe Ser Arg Gln Gly Gln Gly Tyr Arg His Met Asn Leu Thr 
            180                 185                 190         


Ser Thr Asn Lys Tyr Trp Thr Ser Ser Asn Gly Thr Gln Thr Asn Asp 
        195                 200                 205             


Thr Gly Cys Phe Gly Thr Leu His Glu Tyr Asn Ser Thr Lys Asn Gln 
    210                 215                 220                 


Thr Cys Ala Pro Ser Lys Thr Pro Pro Pro Pro Pro Thr Ala Arg Pro 
225                 230                 235                 240 


Glu Ile Lys Pro Thr Ser Thr Pro Thr Asp Ala Thr Arg Leu Asn Thr 
                245                 250                 255     


Thr Asn Pro Asn Ser Asp Asp Glu Asp Leu Thr Thr Ser Gly Ser Gly 
            260                 265                 270         


Ser Gly Glu Gln Glu Leu Tyr Thr Thr Ser Asp Ala Val Thr Lys Gln 
        275                 280                 285             


Gly Leu Ser Ser Thr Met Pro Pro Thr Pro Ser Pro Gln Pro Gly Thr 
    290                 295                 300                 


Pro Gln Gln Gly Gly Asn Asn Thr Asn His Ser Gln Asp Ala Thr Thr 
305                 310                 315                 320 


Glu Leu Asp Asn Thr Asn Thr Thr Ala Gln Pro Pro Thr Pro Ser His 
                325                 330                 335     


Asn Thr Thr Thr Ile Ser Thr Asn Asn Thr Ser Lys His Asn Leu Ser 
            340                 345                 350         


Thr Leu Ser Ala Pro Pro Gln Asn Thr Thr Asn Pro Asn Thr Gln Ser 
        355                 360                 365             


Met Ala Thr Glu Asn Glu Lys Thr Ser Ala Pro Pro Lys Ala Thr Leu 
    370                 375                 380                 


Pro Pro Thr Glu Asn Pro Thr Thr Glu Lys Ser Thr Asn Asn Thr Lys 
385                 390                 395                 400 


Ser Pro Thr Thr Met Glu Pro Asn Thr Thr Asn Gly His Phe Thr Ser 
                405                 410                 415     


Pro Ser Ser Thr Pro Asn Ser Thr Thr Gln His Leu Ile Tyr Phe Arg 
            420                 425                 430         


Arg Lys Arg Ser Ile Leu Trp Arg Glu Gly Asp Met Phe Pro Phe Leu 
        435                 440                 445             


Asp Gly Leu Ile Asn Ala Pro Ile Asp Phe Asp Pro Val Pro Asn Thr 
    450                 455                 460                 


Lys Thr Ile Phe Asp Glu Ser Ser Ser Ser Gly Ala Ser Thr Glu Glu 
465                 470                 475                 480 


Asp Gln His Ala Ser Ser Asn Ile Ser Leu Thr Leu Ser Tyr Leu Pro 
                485                 490                 495     


His Thr Ser Gly Asn Thr Ala Tyr Ser Gly Glu Asn Glu Asn Asp Cys 
            500                 505                 510         


Asp Ala Glu Leu Arg Ile Trp Ser Val Gln Glu Asp Asp Leu Ala Ala 
        515                 520                 525             


Gly Leu Ser Trp Ile Pro Phe Phe Gly Pro Gly Ile Glu Gly Leu Tyr 
    530                 535                 540                 


Thr Ala Gly Leu Ile Lys Asn Gln Asn Asn Leu Val Cys Arg Leu Arg 
545                 550                 555                 560 


Arg Leu Ala Asn Gln Thr Ala Lys Ser Leu Glu Leu Leu Leu Arg Val 
                565                 570                 575     


Thr Thr Glu Glu Arg Thr Phe Ser Leu Ile Asn Arg His Ala Ile Asp 
            580                 585                 590         


Phe Leu Leu Thr Arg Trp Gly Gly Thr Cys Lys Val Leu Gly Pro Asp 
        595                 600                 605             


Cys Cys Ile Gly Ile Glu Asp Leu Ser Arg Asn Ile Ser Glu Gln Ile 
    610                 615                 620                 


Asp Gln Ile Lys Lys Asp Glu Gln Lys Glu Gly Thr Gly Trp Gly Leu 
625                 630                 635                 640 


Gly Gly Lys Trp Trp Thr Ser Asp Trp Gly Val Leu Thr Asn Leu Gly 
                645                 650                 655     


Ile Leu Leu Leu Leu Ser Ile Ala Val Leu Ile Ala Leu Ser Cys Ile 
            660                 665                 670         


Cys Arg Ile Phe Thr Lys Tyr Ile Gly 
        675                 680     


<210>  188
<211>  364
<212>  PRT
<213>  Zaire ebolavirus

<400>  188

Met Gly Val Thr Gly Ile Leu Gln Leu Pro Arg Asp Arg Phe Lys Arg 
1               5                   10                  15      


Thr Ser Phe Phe Leu Trp Val Ile Ile Leu Phe Gln Arg Thr Phe Ser 
            20                  25                  30          


Ile Pro Leu Gly Val Ile His Asn Ser Thr Leu Gln Val Ser Asp Val 
        35                  40                  45              


Asp Lys Leu Val Cys Arg Asp Lys Leu Ser Ser Thr Asn Gln Leu Arg 
    50                  55                  60                  


Ser Val Gly Leu Asn Leu Glu Gly Asn Gly Val Ala Thr Asp Val Pro 
65                  70                  75                  80  


Ser Ala Thr Lys Arg Trp Gly Phe Arg Ser Gly Val Pro Pro Lys Val 
                85                  90                  95      


Val Asn Tyr Glu Ala Gly Glu Trp Ala Glu Asn Cys Tyr Asn Leu Glu 
            100                 105                 110         


Ile Lys Lys Pro Asp Gly Ser Glu Cys Leu Pro Ala Ala Pro Asp Gly 
        115                 120                 125             


Ile Arg Gly Phe Pro Arg Cys Arg Tyr Val His Lys Val Ser Gly Thr 
    130                 135                 140                 


Gly Pro Cys Ala Gly Asp Phe Ala Phe His Lys Glu Gly Ala Phe Phe 
145                 150                 155                 160 


Leu Tyr Asp Arg Leu Ala Ser Thr Val Ile Tyr Arg Gly Thr Thr Phe 
                165                 170                 175     


Ala Glu Gly Val Val Ala Phe Leu Ile Leu Pro Gln Ala Lys Lys Asp 
            180                 185                 190         


Phe Phe Ser Ser His Pro Leu Arg Glu Pro Val Asn Ala Thr Glu Asp 
        195                 200                 205             


Pro Ser Ser Gly Tyr Tyr Ser Thr Thr Ile Arg Tyr Gln Ala Thr Gly 
    210                 215                 220                 


Phe Gly Thr Asn Glu Thr Glu Tyr Leu Phe Glu Val Asp Asn Leu Thr 
225                 230                 235                 240 


Tyr Val Gln Leu Glu Ser Arg Phe Thr Pro Gln Phe Leu Leu Gln Leu 
                245                 250                 255     


Asn Glu Thr Ile Tyr Thr Ser Gly Lys Arg Ser Asn Thr Thr Gly Lys 
            260                 265                 270         


Leu Ile Trp Lys Val Asn Pro Glu Ile Asp Thr Thr Ile Gly Glu Trp 
        275                 280                 285             


Ala Phe Trp Glu Thr Lys Lys Thr Ser Leu Glu Lys Phe Ala Val Lys 
    290                 295                 300                 


Ser Cys Leu Ser Gln Leu Tyr Gln Thr Glu Pro Lys Thr Ser Val Val 
305                 310                 315                 320 


Arg Val Arg Arg Glu Leu Leu Pro Thr Gln Gly Pro Thr Gln Gln Leu 
                325                 330                 335     


Lys Thr Thr Lys Ser Trp Leu Gln Lys Ile Pro Leu Gln Trp Phe Lys 
            340                 345                 350         


Cys Thr Val Lys Glu Gly Lys Leu Gln Cys Arg Ile 
        355                 360                 


<210>  189
<211>  681
<212>  PRT
<213>  Lake Victoria marburgvirus

<400>  189

Met Lys Thr Thr Cys Leu Phe Ile Ser Leu Ile Leu Ile Gln Gly Ile 
1               5                   10                  15      


Lys Thr Leu Pro Ile Leu Glu Ile Ala Ser Asn Asn Gln Pro Gln Asn 
            20                  25                  30          


Val Asp Ser Val Cys Ser Gly Thr Leu Gln Lys Thr Glu Asp Val His 
        35                  40                  45              


Leu Met Gly Phe Thr Leu Ser Gly Gln Lys Val Ala Asp Ser Pro Leu 
    50                  55                  60                  


Glu Ala Ser Lys Arg Trp Ala Phe Arg Thr Gly Val Pro Pro Lys Asn 
65                  70                  75                  80  


Val Glu Tyr Thr Glu Gly Glu Glu Ala Lys Thr Cys Tyr Asn Ile Ser 
                85                  90                  95      


Val Thr Asp Pro Ser Gly Lys Ser Leu Leu Leu Asp Pro Pro Thr Asn 
            100                 105                 110         


Ile Arg Asp Tyr Pro Lys Cys Lys Thr Ile His His Ile Gln Gly Gln 
        115                 120                 125             


Asn Pro His Ala Gln Gly Ile Ala Leu His Leu Trp Gly Ala Phe Phe 
    130                 135                 140                 


Leu Tyr Asp Arg Ile Ala Ser Thr Thr Met Tyr Arg Gly Arg Val Phe 
145                 150                 155                 160 


Thr Glu Gly Asn Ile Ala Ala Met Ile Val Asn Lys Thr Val His Lys 
                165                 170                 175     


Met Ile Phe Ser Arg Gln Gly Gln Gly Tyr Arg His Met Asn Leu Thr 
            180                 185                 190         


Ser Thr Asn Lys Tyr Trp Thr Ser Asn Asn Gly Thr Gln Thr Asn Asp 
        195                 200                 205             


Thr Gly Cys Phe Gly Ala Leu Gln Glu Tyr Asn Ser Thr Lys Asn Gln 
    210                 215                 220                 


Thr Cys Ala Pro Ser Lys Ile Pro Ser Pro Leu Pro Thr Ala Arg Pro 
225                 230                 235                 240 


Glu Ile Lys Pro Thr Ser Thr Pro Thr Asp Ala Thr Thr Leu Asn Thr 
                245                 250                 255     


Thr Asp Pro Asn Asn Asp Asp Glu Asp Leu Ile Thr Ser Gly Ser Gly 
            260                 265                 270         


Ser Gly Glu Gln Glu Pro Tyr Thr Thr Ser Asp Ala Val Thr Lys Gln 
        275                 280                 285             


Gly Leu Ser Ser Thr Met Pro Pro Thr Pro Ser Pro Gln Pro Ser Thr 
    290                 295                 300                 


Pro Gln Gln Glu Gly Asn Asn Thr Asp His Ser Gln Gly Thr Val Thr 
305                 310                 315                 320 


Glu Pro Asn Lys Thr Asn Thr Thr Ala Gln Pro Ser Met Pro Pro His 
                325                 330                 335     


Asn Thr Thr Ala Ile Ser Thr Asn Asn Thr Ser Lys Asn Asn Phe Ser 
            340                 345                 350         


Thr Leu Ser Val Ser Leu Gln Asn Thr Thr Asn Tyr Asp Thr Gln Ser 
        355                 360                 365             


Thr Ala Thr Glu Asn Glu Gln Thr Ser Ala Pro Ser Lys Thr Thr Leu 
    370                 375                 380                 


Pro Pro Thr Gly Asn Leu Thr Thr Ala Lys Ser Thr Asn Asn Thr Lys 
385                 390                 395                 400 


Gly Pro Thr Thr Thr Ala Pro Asn Met Thr Asn Gly His Leu Thr Ser 
                405                 410                 415     


Pro Ser Pro Thr Pro Asn Pro Thr Thr Gln His Leu Val Tyr Phe Arg 
            420                 425                 430         


Lys Lys Arg Ser Ile Leu Trp Arg Glu Gly Asp Met Phe Pro Phe Leu 
        435                 440                 445             


Asp Gly Leu Ile Asn Ala Pro Ile Asp Phe Asp Pro Val Pro Asn Thr 
    450                 455                 460                 


Lys Thr Ile Phe Asp Glu Ser Ser Ser Ser Gly Ala Ser Ala Glu Glu 
465                 470                 475                 480 


Asp Gln His Ala Ser Pro Asn Ile Ser Leu Thr Leu Ser Tyr Phe Pro 
                485                 490                 495     


Asn Ile Asn Glu Asn Thr Ala Tyr Ser Gly Glu Asn Glu Asn Asp Cys 
            500                 505                 510         


Asp Ala Glu Leu Arg Ile Trp Ser Val Gln Glu Asp Asp Leu Ala Ala 
        515                 520                 525             


Gly Leu Ser Trp Ile Pro Phe Phe Gly Pro Gly Ile Glu Gly Leu Tyr 
    530                 535                 540                 


Thr Ala Gly Leu Ile Lys Asn Gln Asn Asn Leu Val Cys Arg Leu Arg 
545                 550                 555                 560 


Arg Leu Ala Asn Gln Thr Ala Lys Ser Leu Glu Leu Leu Leu Arg Val 
                565                 570                 575     


Thr Thr Glu Glu Arg Thr Phe Ser Leu Ile Asn Arg His Ala Ile Asp 
            580                 585                 590         


Phe Leu Leu Thr Arg Trp Gly Gly Thr Cys Lys Val Leu Gly Pro Asp 
        595                 600                 605             


Cys Cys Ile Gly Ile Glu Asp Leu Ser Arg Asn Ile Ser Glu Gln Ile 
    610                 615                 620                 


Asp Gln Ile Lys Lys Asp Glu Gln Lys Glu Gly Thr Gly Trp Gly Leu 
625                 630                 635                 640 


Gly Gly Lys Trp Trp Thr Ser Asp Trp Gly Val Leu Thr Asn Leu Gly 
                645                 650                 655     


Ile Leu Leu Leu Leu Ser Ile Ala Val Leu Ile Ala Leu Ser Cys Ile 
            660                 665                 670         


Cys Arg Ile Phe Thr Lys Tyr Ile Gly 
        675                 680     


<210>  190
<211>  676
<212>  PRT
<213>  Sudan ebolavirus

<400>  190

Met Glu Gly Leu Ser Leu Leu Gln Leu Pro Arg Asp Lys Phe Arg Lys 
1               5                   10                  15      


Ser Ser Phe Phe Val Trp Val Ile Ile Leu Phe Gln Lys Ala Phe Ser 
            20                  25                  30          


Met Pro Leu Gly Val Val Thr Asn Ser Thr Leu Glu Val Thr Glu Ile 
        35                  40                  45              


Asp Gln Leu Val Cys Lys Asp His Leu Ala Ser Thr Asp Gln Leu Lys 
    50                  55                  60                  


Ser Val Gly Leu Asn Leu Glu Gly Ser Gly Val Ser Thr Asp Ile Pro 
65                  70                  75                  80  


Ser Ala Thr Lys Arg Trp Gly Phe Arg Ser Gly Val Pro Pro Gln Val 
                85                  90                  95      


Val Ser Tyr Glu Ala Gly Glu Trp Ala Glu Asn Cys Tyr Asn Leu Glu 
            100                 105                 110         


Ile Lys Lys Pro Asp Gly Ser Glu Cys Leu Pro Pro Pro Pro Asp Gly 
        115                 120                 125             


Val Arg Gly Phe Pro Arg Cys Arg Tyr Val His Lys Ala Gln Gly Thr 
    130                 135                 140                 


Gly Pro Cys Pro Gly Asp Tyr Ala Phe His Lys Asp Gly Ala Phe Phe 
145                 150                 155                 160 


Leu Tyr Asp Arg Leu Ala Ser Thr Val Ile Tyr Arg Gly Val Asn Phe 
                165                 170                 175     


Ala Glu Gly Val Ile Ala Phe Leu Ile Leu Ala Lys Pro Lys Glu Thr 
            180                 185                 190         


Phe Leu Gln Ser Pro Pro Ile Arg Glu Ala Ala Asn Tyr Thr Glu Asn 
        195                 200                 205             


Thr Ser Ser Tyr Tyr Ala Thr Ser Tyr Leu Glu Tyr Glu Ile Glu Asn 
    210                 215                 220                 


Phe Gly Ala Gln His Ser Thr Thr Leu Phe Lys Ile Asn Asn Asn Thr 
225                 230                 235                 240 


Phe Val Leu Leu Asp Arg Pro His Thr Pro Gln Phe Leu Phe Gln Leu 
                245                 250                 255     


Asn Asp Thr Ile Gln Leu His Gln Gln Leu Ser Asn Thr Thr Gly Lys 
            260                 265                 270         


Leu Ile Trp Thr Leu Asp Ala Asn Ile Asn Ala Asp Ile Gly Glu Trp 
        275                 280                 285             


Ala Phe Trp Glu Asn Lys Lys Asn Leu Ser Glu Gln Leu Arg Gly Glu 
    290                 295                 300                 


Glu Leu Ser Phe Glu Thr Leu Ser Leu Asn Glu Thr Glu Asp Asp Asp 
305                 310                 315                 320 


Ala Thr Ser Ser Arg Thr Thr Lys Gly Arg Ile Ser Asp Arg Ala Thr 
                325                 330                 335     


Arg Lys Tyr Ser Asp Leu Val Pro Lys Asp Ser Pro Gly Met Val Ser 
            340                 345                 350         


Leu His Val Pro Glu Gly Glu Thr Thr Leu Pro Ser Gln Asn Ser Thr 
        355                 360                 365             


Glu Gly Arg Arg Val Asp Val Asn Thr Gln Glu Thr Ile Thr Glu Thr 
    370                 375                 380                 


Thr Ala Thr Ile Ile Gly Thr Asn Gly Asn Asn Met Gln Ile Ser Thr 
385                 390                 395                 400 


Ile Gly Thr Gly Leu Ser Ser Ser Gln Ile Leu Ser Ser Ser Pro Thr 
                405                 410                 415     


Met Ala Pro Ser Pro Glu Thr Gln Thr Ser Thr Thr Tyr Thr Pro Lys 
            420                 425                 430         


Leu Pro Val Met Thr Thr Glu Glu Ser Thr Thr Pro Pro Arg Asn Ser 
        435                 440                 445             


Pro Gly Ser Thr Thr Glu Ala Pro Thr Leu Thr Thr Pro Glu Asn Ile 
    450                 455                 460                 


Thr Thr Ala Val Lys Thr Val Trp Pro Gln Glu Ser Thr Ser Asn Gly 
465                 470                 475                 480 


Leu Ile Thr Ser Thr Val Thr Gly Ile Leu Gly Ser Leu Gly Leu Arg 
                485                 490                 495     


Lys Arg Ser Arg Arg Gln Val Asn Thr Arg Ala Thr Gly Lys Cys Asn 
            500                 505                 510         


Pro Asn Leu His Tyr Trp Thr Ala Gln Glu Gln His Asn Ala Ala Gly 
        515                 520                 525             


Ile Ala Trp Ile Pro Tyr Phe Gly Pro Gly Ala Glu Gly Ile Tyr Thr 
    530                 535                 540                 


Glu Gly Leu Met His Asn Gln Asn Ala Leu Val Cys Gly Leu Arg Gln 
545                 550                 555                 560 


Leu Ala Asn Glu Thr Thr Gln Ala Leu Gln Leu Phe Leu Arg Ala Thr 
                565                 570                 575     


Thr Glu Leu Arg Thr Tyr Thr Ile Leu Asn Arg Lys Ala Ile Asp Phe 
            580                 585                 590         


Leu Leu Arg Arg Trp Gly Gly Thr Cys Arg Ile Leu Gly Pro Asp Cys 
        595                 600                 605             


Cys Ile Glu Pro His Asp Trp Thr Lys Asn Ile Thr Asp Lys Ile Asn 
    610                 615                 620                 


Gln Ile Ile His Asp Phe Ile Asp Asn Pro Leu Pro Asn Gln Asp Asn 
625                 630                 635                 640 


Asp Asp Asn Trp Trp Thr Gly Trp Arg Gln Trp Ile Pro Ala Gly Ile 
                645                 650                 655     


Gly Ile Thr Gly Ile Ile Ile Ala Ile Ile Ala Leu Leu Cys Val Cys 
            660                 665                 670         


Lys Leu Leu Cys 
        675     


<210>  191
<211>  367
<212>  PRT
<213>  Reston ebolavirus

<400>  191

Met Gly Ser Gly Tyr Gln Leu Leu Gln Leu Pro Arg Glu Arg Phe Arg 
1               5                   10                  15      


Lys Thr Ser Phe Leu Val Trp Val Ile Ile Leu Phe Gln Arg Ala Ile 
            20                  25                  30          


Ser Met Pro Leu Gly Ile Val Thr Asn Ser Thr Leu Lys Ala Thr Glu 
        35                  40                  45              


Ile Asp Gln Leu Val Cys Arg Asp Lys Leu Ser Ser Thr Ser Gln Leu 
    50                  55                  60                  


Lys Ser Val Gly Leu Asn Leu Glu Gly Asn Gly Ile Ala Thr Asp Val 
65                  70                  75                  80  


Pro Ser Ala Thr Lys Arg Trp Gly Phe Arg Ser Gly Val Pro Pro Lys 
                85                  90                  95      


Val Val Ser Tyr Glu Ala Gly Glu Trp Ala Glu Asn Cys Tyr Asn Leu 
            100                 105                 110         


Glu Ile Lys Lys Ser Asp Gly Ser Glu Cys Leu Pro Leu Pro Pro Asp 
        115                 120                 125             


Gly Val Arg Gly Phe Pro Arg Cys Arg Tyr Val His Lys Val Gln Gly 
    130                 135                 140                 


Thr Gly Pro Cys Pro Gly Asp Leu Ala Phe His Lys Asn Gly Ala Phe 
145                 150                 155                 160 


Phe Leu Tyr Asp Arg Leu Ala Ser Thr Val Ile Tyr Arg Gly Thr Thr 
                165                 170                 175     


Phe Ala Glu Gly Val Val Ala Phe Leu Ile Leu Ser Glu Pro Lys Lys 
            180                 185                 190         


His Phe Trp Lys Ala Thr Pro Ala His Glu Pro Val Asn Thr Thr Asp 
        195                 200                 205             


Asp Ser Thr Ser Tyr Tyr Met Thr Leu Thr Leu Ser Tyr Glu Met Ser 
    210                 215                 220                 


Asn Phe Gly Gly Asn Glu Ser Asn Thr Leu Phe Lys Val Asp Asn His 
225                 230                 235                 240 


Thr Tyr Val Gln Leu Asp Arg Pro His Thr Pro Gln Phe Leu Val Gln 
                245                 250                 255     


Leu Asn Glu Thr Leu Arg Arg Asn Asn Arg Leu Ser Asn Ser Thr Gly 
            260                 265                 270         


Arg Leu Thr Trp Thr Leu Asp Pro Lys Ile Glu Pro Asp Val Gly Glu 
        275                 280                 285             


Trp Ala Phe Trp Glu Thr Lys Lys Thr Phe Pro Asn Asn Phe Met Glu 
    290                 295                 300                 


Lys Thr Cys Ile Ser Lys Phe Tyr Gln Pro Thr Pro Thr Thr Pro Gln 
305                 310                 315                 320 


Ile Arg Ala Arg Arg Glu Leu Ser Lys Glu Lys Leu Ala Thr Thr His 
                325                 330                 335     


Pro Pro Thr Thr Pro Ser Trp Phe Gln Arg Ile Pro Leu Gln Trp Phe 
            340                 345                 350         


Gln Cys Ser Leu Gln Asp Gly Gln Arg Lys Cys Arg Pro Lys Val 
        355                 360                 365         


<210>  192
<211>  319
<212>  PRT
<213>  Sudan ebolavirus

<400>  192

Met Gly Gly Leu Ser Leu Leu Gln Leu Pro Arg Asp Lys Phe Arg Lys 
1               5                   10                  15      


Ser Ser Phe Phe Val Trp Val Ile Ile Leu Phe Gln Lys Ala Phe Ser 
            20                  25                  30          


Met Pro Leu Gly Val Val Thr Asn Ser Thr Leu Glu Val Thr Glu Ile 
        35                  40                  45              


Asp Gln Leu Val Cys Lys Asp His Leu Ala Ser Thr Asp Gln Leu Lys 
    50                  55                  60                  


Ser Val Gly Leu Asn Leu Glu Gly Ser Gly Val Ser Thr Asp Ile Pro 
65                  70                  75                  80  


Ser Ala Thr Lys Arg Trp Gly Phe Arg Ser Gly Val Pro Pro Lys Val 
                85                  90                  95      


Val Ser Tyr Glu Ala Gly Glu Trp Ala Glu Asn Cys Tyr Asn Leu Glu 
            100                 105                 110         


Ile Lys Lys Pro Asp Gly Ser Glu Cys Leu Pro Pro Pro Pro Asp Gly 
        115                 120                 125             


Val Arg Gly Phe Pro Arg Cys Arg Tyr Val His Lys Ala Gln Gly Thr 
    130                 135                 140                 


Gly Pro Cys Pro Gly Asp Tyr Ala Phe His Lys Asp Gly Ala Phe Phe 
145                 150                 155                 160 


Leu Tyr Asp Arg Leu Ala Ser Thr Val Ile Tyr Arg Gly Val Asn Phe 
                165                 170                 175     


Ala Glu Gly Val Ile Ala Phe Leu Ile Leu Ala Lys Pro Lys Glu Thr 
            180                 185                 190         


Phe Leu Gln Ser Pro Pro Ile Arg Glu Ala Val Asn Tyr Thr Glu Asn 
        195                 200                 205             


Thr Ser Ser Tyr Tyr Ala Thr Ser Tyr Leu Glu Tyr Glu Ile Glu Asn 
    210                 215                 220                 


Phe Gly Ala Gln His Ser Thr Thr Leu Phe Lys Ile Asp Asn Asn Thr 
225                 230                 235                 240 


Phe Val Arg Leu Asp Arg Pro His Thr Pro Gln Phe Leu Phe Gln Leu 
                245                 250                 255     


Asn Asp Thr Ile His Leu His Gln Gln Leu Ser Asn Thr Thr Gly Arg 
            260                 265                 270         


Leu Ile Trp Thr Leu Asp Ala Asn Ile Asn Ala Asp Ile Gly Glu Trp 
        275                 280                 285             


Ala Phe Trp Glu Asn Lys Lys Lys Ser Leu Arg Thr Thr Thr Trp Arg 
    290                 295                 300                 


Arg Ala Val Phe Arg Ser Phe Ile Ala Gln Arg Asp Arg Arg Arg 
305                 310                 315                 


<210>  193
<211>  676
<212>  PRT
<213>  Zaire ebolavirus

<400>  193

Met Gly Val Thr Gly Ile Leu Gln Leu Pro Arg Asp Arg Phe Lys Arg 
1               5                   10                  15      


Thr Ser Phe Phe Leu Trp Val Ile Ile Leu Phe Gln Arg Thr Phe Ser 
            20                  25                  30          


Ile Pro Leu Gly Val Ile His Asn Ser Thr Leu Gln Val Ser Asp Val 
        35                  40                  45              


Asp Lys Leu Val Cys Arg Asp Lys Leu Ser Ser Thr Asn Gln Leu Arg 
    50                  55                  60                  


Ser Val Gly Leu Asn Leu Glu Gly Asn Gly Val Ala Thr Asp Val Pro 
65                  70                  75                  80  


Ser Ala Thr Lys Arg Trp Gly Phe Arg Ser Gly Val Pro Pro Lys Val 
                85                  90                  95      


Val Asn Tyr Glu Ala Gly Glu Trp Ala Glu Asn Cys Tyr Asn Leu Glu 
            100                 105                 110         


Ile Lys Lys Pro Asp Gly Ser Glu Cys Leu Pro Ala Ala Pro Asp Gly 
        115                 120                 125             


Ile Arg Gly Phe Pro Arg Cys Arg Tyr Val His Lys Val Ser Gly Thr 
    130                 135                 140                 


Gly Pro Cys Ala Gly Asp Phe Ala Phe His Lys Glu Gly Ala Phe Phe 
145                 150                 155                 160 


Leu Tyr Asp Arg Leu Ala Ser Thr Val Ile Tyr Arg Gly Thr Thr Phe 
                165                 170                 175     


Ala Glu Gly Val Val Ala Phe Leu Ile Leu Pro Gln Ala Lys Lys Asp 
            180                 185                 190         


Phe Phe Ser Ser His Pro Leu Arg Glu Pro Val Asn Ala Thr Glu Asp 
        195                 200                 205             


Pro Ser Ser Gly Tyr Tyr Ser Thr Thr Ile Arg Tyr Gln Ala Thr Gly 
    210                 215                 220                 


Phe Gly Thr Asn Glu Thr Glu Tyr Leu Phe Glu Val Asp Asn Leu Thr 
225                 230                 235                 240 


Tyr Val Gln Leu Glu Ser Arg Phe Thr Pro Gln Phe Leu Leu Gln Leu 
                245                 250                 255     


Asn Glu Thr Arg Tyr Thr Ser Gly Lys Arg Ser Asn Thr Thr Gly Lys 
            260                 265                 270         


Leu Ile Trp Lys Val Asn Pro Glu Ile Asp Thr Thr Ile Gly Glu Trp 
        275                 280                 285             


Ala Phe Trp Glu Thr Lys Lys Asn Leu Thr Arg Lys Ile Arg Ser Glu 
    290                 295                 300                 


Glu Leu Ser Phe Thr Ala Val Ser Asn Arg Ala Lys Asn Ile Ser Gly 
305                 310                 315                 320 


Gln Ser Pro Ala Arg Thr Ser Ser Asp Pro Gly Thr Asn Thr Thr Thr 
                325                 330                 335     


Glu Asp His Lys Ile Met Ala Ser Glu Asn Ser Ser Ala Met Val Gln 
            340                 345                 350         


Val His Ser Gln Gly Arg Glu Ala Ala Val Ser His Leu Thr Thr Leu 
        355                 360                 365             


Ala Thr Ile Ser Thr Ser Leu Arg Pro Pro Ile Thr Lys Pro Gly Pro 
    370                 375                 380                 


Asp Asn Ser Thr His Asn Thr Pro Val Tyr Lys Leu Asp Ile Ser Glu 
385                 390                 395                 400 


Ala Thr Gln Val Glu Gln His His Arg Arg Thr Asp Asn Ala Ser Thr 
                405                 410                 415     


Thr Ser Asp Thr Pro Pro Ala Thr Thr Ala Ala Gly Pro Leu Lys Ala 
            420                 425                 430         


Glu Asn Thr Asn Thr Ser Lys Gly Thr Asp Leu Leu Asp Pro Ala Thr 
        435                 440                 445             


Thr Thr Ser Pro Gln Asn His Ser Glu Thr Ala Gly Asn Asn Asn Thr 
    450                 455                 460                 


His His Gln Asp Thr Gly Glu Glu Ser Ala Ser Ser Gly Lys Leu Gly 
465                 470                 475                 480 


Leu Ile Thr Asn Thr Ile Ala Gly Val Ala Gly Leu Ile Thr Gly Gly 
                485                 490                 495     


Arg Arg Thr Arg Arg Glu Ala Ile Val Asn Ala Gln Pro Lys Cys Asn 
            500                 505                 510         


Pro Asn Leu His Tyr Trp Thr Thr Gln Asp Glu Gly Ala Ala Ile Gly 
        515                 520                 525             


Leu Ala Trp Ile Pro Tyr Phe Gly Pro Ala Ala Glu Gly Ile Tyr Ile 
    530                 535                 540                 


Glu Gly Leu Met His Asn Gln Asp Gly Leu Ile Cys Gly Leu Arg Gln 
545                 550                 555                 560 


Leu Ala Asn Glu Thr Thr Gln Ala Leu Gln Leu Phe Leu Arg Ala Thr 
                565                 570                 575     


Thr Glu Leu Arg Thr Phe Ser Ile Leu Asn Arg Lys Ala Ile Asp Phe 
            580                 585                 590         


Leu Leu Gln Arg Trp Gly Gly Thr Cys His Ile Leu Gly Pro Asp Cys 
        595                 600                 605             


Cys Ile Glu Pro His Asp Trp Thr Lys Asn Ile Thr Asp Lys Ile Asp 
    610                 615                 620                 


Gln Ile Ile His Asp Phe Val Asp Lys Thr Leu Pro Asp Gln Gly Asp 
625                 630                 635                 640 


Asn Asp Asn Trp Trp Thr Gly Trp Arg Gln Trp Ile Pro Ala Gly Ile 
                645                 650                 655     


Gly Val Thr Gly Val Ile Ile Ala Val Ile Ala Leu Phe Cys Ile Cys 
            660                 665                 670         


Lys Phe Val Phe 
        675     


<210>  194
<211>  332
<212>  PRT
<213>  Reston ebolavirus

<400>  194

Met Gly Ser Gly Tyr Gln Leu Leu Gln Leu Pro Arg Glu Arg Phe Arg 
1               5                   10                  15      


Lys Thr Ser Phe Leu Val Trp Val Ile Ile Leu Phe Gln Arg Ala Ile 
            20                  25                  30          


Ser Met Pro Leu Gly Ile Val Thr Asn Ser Thr Leu Lys Ala Thr Glu 
        35                  40                  45              


Ile Asp Gln Leu Val Cys Arg Asp Lys Leu Ser Ser Thr Ser Gln Leu 
    50                  55                  60                  


Lys Ser Val Gly Leu Asn Leu Glu Gly Asn Gly Ile Ala Thr Asp Val 
65                  70                  75                  80  


Pro Ser Ala Thr Lys Arg Trp Gly Phe Arg Ser Gly Val Pro Pro Lys 
                85                  90                  95      


Val Val Ser Tyr Glu Ala Gly Glu Trp Ala Glu Asn Cys Tyr Asn Leu 
            100                 105                 110         


Glu Ile Lys Lys Ser Asp Gly Ser Glu Cys Leu Pro Leu Pro Pro Asp 
        115                 120                 125             


Gly Val Arg Gly Phe Pro Arg Cys Arg Tyr Val His Lys Val Gln Gly 
    130                 135                 140                 


Thr Gly Pro Cys Pro Gly Asp Leu Ala Phe His Lys Asn Gly Ala Phe 
145                 150                 155                 160 


Phe Leu Tyr Asp Arg Leu Ala Ser Thr Val Ile Tyr Arg Gly Thr Thr 
                165                 170                 175     


Phe Ala Glu Gly Val Val Ala Phe Leu Ile Leu Ser Glu Pro Lys Lys 
            180                 185                 190         


His Phe Trp Lys Ala Thr Pro Ala His Glu Pro Val Asn Thr Thr Asp 
        195                 200                 205             


Asp Ser Thr Ser Tyr Tyr Met Thr Leu Thr Leu Ser Tyr Glu Met Ser 
    210                 215                 220                 


Asn Phe Gly Gly Asn Glu Ser Asn Thr Leu Phe Lys Val Asp Asn His 
225                 230                 235                 240 


Thr Tyr Val Gln Leu Asp Arg Pro His Thr Pro Gln Phe Leu Val Gln 
                245                 250                 255     


Leu Asn Glu Thr Leu Arg Arg Asn Asn Arg Leu Ser Asn Ser Thr Gly 
            260                 265                 270         


Arg Leu Thr Trp Thr Leu Asp Pro Lys Ile Glu Pro Asp Val Gly Glu 
        275                 280                 285             


Trp Ala Phe Trp Glu Thr Lys Lys Lys Leu Phe Pro Thr Thr Ser Trp 
    290                 295                 300                 


Arg Lys Leu Ala Phe Pro Asn Ser Ile Asn Pro His Gln Gln Leu Leu 
305                 310                 315                 320 


Arg Ser Glu Pro Gly Gly Asn Cys Pro Arg Lys Asn 
                325                 330         


<210>  195
<211>  568
<212>  PRT
<213>  Simian virus 41

<400>  195

Met Ser Gly Ala Glu Gly Asn Thr Asn Lys Arg Thr Phe Arg Ala Val 
1               5                   10                  15      


Phe Arg Thr Leu Ile Ile Leu Ile Thr Leu Thr Ile Leu Ala Leu Ser 
            20                  25                  30          


Ala Ala Ile Leu Tyr Glu Val Thr His Thr Ser Asn Gly Ser Glu Ser 
        35                  40                  45              


Asn Asn Gln Val Phe Asp Pro Thr Asp Thr Leu Asn Ala Ile Thr Gly 
    50                  55                  60                  


Asn Ile Lys Ser Met Ile Ala Leu Leu Asn Gln Ile Leu Tyr Asn Ala 
65                  70                  75                  80  


Ala Ile Ala Leu Pro Leu Lys Ile Asp Ser Thr Glu Ser Val Leu Leu 
                85                  90                  95      


Ala Ala Ile Lys Asp Leu Gln Phe Ser Asn Pro Ala Ser Gln Asn Cys 
            100                 105                 110         


Ser Ser Gly Gly Asn Leu Leu Asn Asp Ala Leu Tyr Ile Asn Gly Ile 
        115                 120                 125             


Asn Gln Tyr Leu Leu Ser Asn Ser Phe Ala Gly Thr Val Gly Leu Gly 
    130                 135                 140                 


Pro Leu Leu Asn Ile Pro Ser Phe Ile Pro Ser Ala Thr Ala Pro Gly 
145                 150                 155                 160 


Gly Cys Thr Arg Ile Pro Ser Phe Ser Leu Thr Lys Thr His Trp Cys 
                165                 170                 175     


Tyr Ser His Asn Val Ile Leu Ala Gly Cys Ala Asp Ser Lys Ala Ser 
            180                 185                 190         


Asn Gln Tyr Leu Ala Met Gly Ile Val Glu Gln Ser Ser Ala Asp Phe 
        195                 200                 205             


Pro Phe Phe Arg Thr Met Arg Thr Leu Tyr Leu Ser Asp Gly Ile Asn 
    210                 215                 220                 


Arg Lys Ser Cys Ser Ile Val Ala Ile Pro Gly Gly Cys Ala Leu Tyr 
225                 230                 235                 240 


Cys Tyr Val Ala Thr Lys Thr Glu Gln Glu Asp Tyr Ala Ala Thr Thr 
                245                 250                 255     


Pro Ser Glu Leu Arg Leu Thr Phe Tyr Tyr Tyr Asn Glu Thr Leu Val 
            260                 265                 270         


Glu Arg Thr Leu Thr Ile Pro Asn Val Thr Gly Asn Trp Ala Thr Leu 
        275                 280                 285             


Asn Pro Ala Val Gly Ser Gly Val Tyr His Leu Gly Tyr Leu Ala Phe 
    290                 295                 300                 


Pro Val Tyr Gly Gly Leu Ile Gln Asn Ser Ala Ala Trp Asn Ser Gln 
305                 310                 315                 320 


Phe Gly Ser Tyr Phe Leu Pro Gln Asn Pro Ala Val Gln Cys Ser Gly 
                325                 330                 335     


Ser Ala Glu Gln Gln Ile Asn Thr Ala Lys Gly Ser Tyr Val Val Asn 
            340                 345                 350         


Trp Phe Ser Gly Arg Leu Ile Gln Ser Ala Val Leu Val Cys Pro Leu 
        355                 360                 365             


Ser Asp Gln Leu Thr Asp Gln Cys Arg Val Val Leu Phe Asn Asn Ser 
    370                 375                 380                 


Glu Thr Met Met Gly Ala Glu Gly Arg Leu Tyr Thr Ile Gly Gly Asp 
385                 390                 395                 400 


Leu Tyr Tyr Tyr Gln Arg Ser Ser Ser Trp Trp Thr Ala Ser Leu Leu 
                405                 410                 415     


Tyr Lys Ile Asn Thr Asp Phe Ser Gln Gly Leu Pro Pro Leu Ile Glu 
            420                 425                 430         


Ala Gln Trp Val Pro Thr Tyr Leu Val Pro Arg Pro Gly Ala Gln Pro 
        435                 440                 445             


Cys Ser Ala Gly Asn Phe Cys Pro Ala Asn Cys Ile Thr Gly Val Tyr 
    450                 455                 460                 


Ala Asp Val Trp Pro Met Asn Asn Pro Phe Pro Ala Gly Ser Ser Gly 
465                 470                 475                 480 


Val Asn Pro Asn Tyr Leu Phe Gly Gly Ala Phe Leu Trp Ala Asp Val 
                485                 490                 495     


Ala Arg Val Asn Pro Thr Phe Tyr Met Ala Ser Ala Thr Gln Tyr Lys 
            500                 505                 510         


Asn Thr Thr Gly Phe Pro Asn Ser Asn Gln Lys Ala Ala Tyr Thr Ser 
        515                 520                 525             


Thr Thr Cys Phe Gln Asn Thr Gly Ser Lys Lys Ile Tyr Cys Leu Phe 
    530                 535                 540                 


Ile Ile Glu Met Gly Ser Ser Leu Met Gly Glu Phe Gln Ile Val Pro 
545                 550                 555                 560 


Phe Leu Arg Glu Val Ile Ile Thr 
                565             


<210>  196
<211>  616
<212>  PRT
<213>  Newcastle disease virus

<400>  196

Met Asp Arg Ala Val Ser Gln Val Ala Leu Glu Asn Asp Glu Arg Glu 
1               5                   10                  15      


Ala Lys Asn Thr Trp Arg Leu Val Phe Arg Ile Ala Ile Leu Leu Leu 
            20                  25                  30          


Thr Val Val Thr Leu Ala Ile Ser Ala Ala Ala Leu Ala Tyr Ser Met 
        35                  40                  45              


Glu Ala Ser Thr Pro Ser Asp Leu Val Gly Ile Pro Thr Ala Ile Ser 
    50                  55                  60                  


Arg Thr Glu Glu Lys Ile Thr Ser Ala Leu Gly Ser Asn Gln Asp Val 
65                  70                  75                  80  


Val Asp Arg Ile Tyr Lys Gln Val Ala Leu Glu Ser Pro Leu Ala Leu 
                85                  90                  95      


Leu Asn Thr Glu Ser Thr Ile Met Asn Ala Ile Thr Ser Leu Ser Tyr 
            100                 105                 110         


Gln Ile Asn Gly Ala Ala Asn Ser Ser Gly Cys Gly Ala Pro Ile His 
        115                 120                 125             


Asp Pro Asp Tyr Ile Gly Gly Ile Gly Lys Glu Leu Ile Val Asp Asp 
    130                 135                 140                 


Ala Ser Asp Val Thr Ser Phe Tyr Pro Ser Ala Phe Gln Glu His Leu 
145                 150                 155                 160 


Asn Phe Ile Pro Ala Pro Thr Thr Gly Ser Gly Cys Thr Arg Ile Pro 
                165                 170                 175     


Ser Phe Asp Met Ser Ala Thr His Tyr Cys Tyr Thr His Asn Val Ile 
            180                 185                 190         


Leu Ser Gly Cys Arg Asp Arg Ser His Ser His Gln Tyr Leu Ala Leu 
        195                 200                 205             


Gly Val Leu Arg Thr Ser Ala Thr Gly Arg Val Phe Phe Ser Thr Leu 
    210                 215                 220                 


Arg Ser Ile Asn Leu Asp Asp Thr Gln Asn Arg Lys Ser Cys Ser Val 
225                 230                 235                 240 


Ser Ala Thr Pro Leu Gly Cys Asp Met Leu Cys Ser Lys Val Thr Glu 
                245                 250                 255     


Thr Glu Glu Glu Asp Tyr Asn Ser Ala Ile Pro Thr Ser Met Val His 
            260                 265                 270         


Gly Arg Leu Gly Phe Asp Gly Gln Tyr His Glu Lys Asp Leu Asp Val 
        275                 280                 285             


Thr Thr Leu Phe Glu Asp Trp Val Ala Asn Tyr Pro Gly Val Gly Gly 
    290                 295                 300                 


Gly Ser Phe Ile Asp Asn Arg Val Trp Phe Pro Val Tyr Gly Gly Leu 
305                 310                 315                 320 


Lys Pro Asn Ser Pro Ser Asp Thr Ala Gln Glu Gly Lys Tyr Val Ile 
                325                 330                 335     


Tyr Lys Arg Tyr Asn Asp Thr Cys Pro Asp Glu Gln Asp Tyr Gln Ile 
            340                 345                 350         


Arg Met Ala Lys Ser Ser Tyr Lys Pro Gly Arg Phe Gly Gly Lys Arg 
        355                 360                 365             


Val Gln Gln Ala Ile Leu Ser Ile Lys Val Ser Thr Ser Leu Gly Glu 
    370                 375                 380                 


Asp Pro Val Leu Thr Val Pro Pro Asn Thr Val Thr Leu Met Gly Ala 
385                 390                 395                 400 


Glu Gly Arg Val Leu Thr Val Gly Thr Ser His Phe Phe Tyr Gln Arg 
                405                 410                 415     


Gly Ser Ser Tyr Phe Ser Pro Ala Leu Leu Tyr Pro Met Thr Val Ser 
            420                 425                 430         


Asn Lys Thr Ala Thr Leu His Ser Pro Tyr Thr Phe Asn Ala Phe Thr 
        435                 440                 445             


Arg Pro Gly Ser Val Pro Cys Gln Ala Ser Ala Arg Cys Pro Asn Ser 
    450                 455                 460                 


Cys Val Thr Gly Val Tyr Thr Asp Pro Tyr Pro Leu Val Phe Tyr Arg 
465                 470                 475                 480 


Asn His Thr Leu Arg Gly Val Phe Gly Thr Met Leu Asp Asp Glu Gln 
                485                 490                 495     


Ala Arg Leu Asn Pro Val Ser Ala Val Phe Asp Ser Ile Ser Arg Ser 
            500                 505                 510         


Arg Ile Thr Arg Val Ser Ser Ser Ser Thr Lys Ala Ala Tyr Thr Thr 
        515                 520                 525             


Ser Thr Cys Phe Lys Val Val Lys Thr Asn Lys Thr Tyr Cys Leu Ser 
    530                 535                 540                 


Ile Ala Glu Ile Ser Asn Thr Leu Phe Gly Glu Phe Arg Ile Val Pro 
545                 550                 555                 560 


Leu Leu Val Glu Ile Leu Lys Asp Asp Gly Val Arg Glu Ala Arg Ser 
                565                 570                 575     


Gly Arg Leu Ser Gln Leu Gln Glu Gly Trp Lys Asp Asp Ile Val Ser 
            580                 585                 590         


Pro Ile Phe Cys Asp Ala Lys Asn Gln Thr Glu Tyr Arg Arg Glu Leu 
        595                 600                 605             


Glu Ser Tyr Ala Ala Ser Trp Pro 
    610                 615     


<210>  197
<211>  645
<212>  PRT
<213>  Xenotropic MuLV-related virus

<400>  197

Met Glu Ser Pro Ala Phe Ser Lys Pro Leu Lys Asp Lys Ile Asn Pro 
1               5                   10                  15      


Trp Gly Pro Leu Ile Ile Met Gly Ile Leu Val Arg Ala Gly Ala Ser 
            20                  25                  30          


Val Gln Arg Asp Ser Pro His Gln Val Phe Asn Val Thr Trp Lys Ile 
        35                  40                  45              


Thr Asn Leu Met Thr Gly Gln Thr Ala Asn Ala Thr Ser Leu Leu Gly 
    50                  55                  60                  


Thr Met Thr Asp Thr Phe Pro Lys Leu Tyr Phe Asp Leu Cys Asp Leu 
65                  70                  75                  80  


Val Gly Asp Asn Trp Asp Asp Pro Glu Pro Asp Ile Gly Asp Gly Cys 
                85                  90                  95      


Arg Ser Pro Gly Gly Arg Lys Arg Thr Arg Leu Tyr Asp Phe Tyr Val 
            100                 105                 110         


Cys Pro Gly His Thr Val Leu Thr Gly Cys Gly Gly Pro Arg Glu Gly 
        115                 120                 125             


Tyr Cys Gly Lys Trp Gly Cys Glu Thr Thr Gly Gln Ala Tyr Trp Lys 
    130                 135                 140                 


Pro Ser Ser Ser Trp Asp Leu Ile Ser Leu Lys Arg Gly Asn Thr Pro 
145                 150                 155                 160 


Lys Gly Gln Gly Pro Cys Phe Asp Ser Ser Val Gly Ser Gly Ser Ile 
                165                 170                 175     


Gln Gly Ala Thr Pro Gly Gly Arg Cys Asn Pro Leu Val Leu Glu Phe 
            180                 185                 190         


Thr Asp Ala Gly Lys Arg Ala Ser Trp Asp Ala Pro Lys Thr Trp Gly 
        195                 200                 205             


Leu Arg Leu Tyr Arg Ser Thr Gly Ala Asp Pro Val Thr Leu Phe Ser 
    210                 215                 220                 


Leu Thr Arg Gln Val Leu Asn Val Gly Pro Arg Val Pro Ile Gly Pro 
225                 230                 235                 240 


Asn Pro Val Ile Thr Glu Gln Leu Pro Pro Ser Gln Pro Val Gln Ile 
                245                 250                 255     


Met Leu Pro Arg Pro Pro Arg Pro Pro Pro Ser Gly Ala Ala Ser Met 
            260                 265                 270         


Val Pro Gly Ala Pro Pro Pro Ser Gln Gln Pro Gly Thr Gly Asp Arg 
        275                 280                 285             


Leu Leu Asn Leu Val Glu Gly Ala Tyr Gln Ala Leu Asn Leu Thr Ser 
    290                 295                 300                 


Pro Asp Lys Thr Gln Glu Cys Trp Leu Cys Leu Val Ser Gly Pro Pro 
305                 310                 315                 320 


Tyr Tyr Glu Gly Val Ala Val Leu Gly Thr Tyr Ser Asn His Thr Ser 
                325                 330                 335     


Ala Pro Ala Asn Cys Ser Val Thr Ser Gln His Lys Leu Thr Leu Ser 
            340                 345                 350         


Glu Val Thr Gly Gln Gly Leu Cys Ile Gly Ala Val Pro Lys Thr His 
        355                 360                 365             


Gln Ala Leu Cys Asn Thr Thr Gln Lys Thr Ser Asp Gly Ser Tyr Tyr 
    370                 375                 380                 


Leu Ala Ser Pro Ala Gly Thr Ile Trp Ala Cys Ser Thr Gly Leu Thr 
385                 390                 395                 400 


Pro Cys Leu Ser Thr Thr Val Leu Asn Leu Thr Thr Asp Tyr Cys Val 
                405                 410                 415     


Leu Val Glu Leu Trp Pro Lys Val Thr Tyr His Ser Pro Asn Tyr Val 
            420                 425                 430         


Tyr Gly Gln Phe Glu Lys Lys Thr Lys Tyr Lys Arg Glu Pro Val Ser 
        435                 440                 445             


Leu Thr Leu Ala Leu Leu Leu Gly Gly Leu Thr Met Gly Gly Ile Ala 
    450                 455                 460                 


Ala Gly Val Gly Thr Gly Thr Thr Ala Leu Val Ala Thr Lys Gln Phe 
465                 470                 475                 480 


Glu Gln Leu Gln Ala Ala Ile His Thr Asp Leu Gly Ala Leu Glu Lys 
                485                 490                 495     


Ser Val Ser Ala Leu Glu Lys Ser Leu Thr Ser Leu Ser Glu Val Val 
            500                 505                 510         


Leu Gln Asn Arg Arg Gly Leu Asp Leu Leu Phe Leu Lys Glu Gly Gly 
        515                 520                 525             


Leu Cys Ala Ala Leu Lys Glu Glu Cys Cys Phe Tyr Ala Asp His Thr 
    530                 535                 540                 


Gly Val Val Arg Asp Ser Met Ala Lys Leu Arg Glu Arg Leu Asn Gln 
545                 550                 555                 560 


Arg Gln Lys Leu Phe Glu Ser Gly Gln Gly Trp Phe Glu Gly Leu Phe 
                565                 570                 575     


Asn Arg Ser Pro Trp Phe Thr Thr Leu Ile Ser Thr Ile Met Gly Pro 
            580                 585                 590         


Leu Ile Val Leu Leu Leu Ile Leu Leu Phe Gly Pro Cys Ile Leu Asn 
        595                 600                 605             


Arg Leu Val Gln Phe Val Lys Asp Arg Ile Ser Val Val Gln Ala Leu 
    610                 615                 620                 


Val Leu Thr Gln Gln Tyr His Gln Leu Lys Ser Ile Asp Pro Glu Glu 
625                 630                 635                 640 


Val Glu Ser Arg Glu 
                645 


<210>  198
<211>  645
<212>  PRT
<213>  Xenotropic MuLV-related virus

<400>  198

Met Glu Ser Pro Ala Phe Ser Lys Pro Leu Lys Asp Lys Ile Asn Pro 
1               5                   10                  15      


Trp Gly Pro Leu Ile Ile Met Gly Ile Leu Val Arg Ala Gly Ala Ser 
            20                  25                  30          


Val Gln Arg Asp Ser Pro His Gln Val Phe Asn Val Thr Trp Lys Ile 
        35                  40                  45              


Thr Asn Leu Met Thr Gly Gln Thr Ala Asn Ala Thr Ser Leu Leu Gly 
    50                  55                  60                  


Thr Met Thr Asp Thr Phe Pro Lys Leu Tyr Phe Asp Leu Cys Asp Leu 
65                  70                  75                  80  


Val Gly Asp Asn Trp Asp Asp Pro Glu Pro Asp Ile Gly Asp Gly Cys 
                85                  90                  95      


Arg Ser Pro Gly Gly Arg Lys Arg Thr Arg Leu Tyr Asp Phe Tyr Val 
            100                 105                 110         


Cys Pro Gly His Thr Val Leu Thr Gly Cys Gly Gly Pro Arg Glu Gly 
        115                 120                 125             


Tyr Cys Gly Lys Trp Gly Cys Glu Thr Thr Gly Gln Ala Tyr Trp Lys 
    130                 135                 140                 


Pro Ser Ser Ser Trp Asp Leu Ile Ser Leu Lys Arg Gly Asn Thr Pro 
145                 150                 155                 160 


Lys Gly Gln Gly Pro Cys Phe Asp Ser Ser Val Gly Ser Gly Ser Ile 
                165                 170                 175     


Gln Gly Ala Thr Pro Gly Gly Arg Cys Asn Pro Leu Val Leu Glu Phe 
            180                 185                 190         


Thr Asp Ala Gly Lys Arg Ala Ser Trp Asp Ala Pro Lys Thr Trp Gly 
        195                 200                 205             


Leu Arg Leu Tyr Arg Ser Thr Gly Ala Asp Pro Val Thr Leu Phe Ser 
    210                 215                 220                 


Leu Thr Arg Gln Val Leu Asn Val Gly Pro Arg Val Pro Ile Gly Pro 
225                 230                 235                 240 


Asn Pro Val Ile Thr Glu Gln Leu Pro Pro Ser Gln Pro Val Gln Ile 
                245                 250                 255     


Met Leu Pro Arg Thr Pro Arg Pro Pro Pro Ser Gly Ala Ala Ser Met 
            260                 265                 270         


Val Pro Gly Ala Pro Pro Pro Ser Gln Gln Pro Gly Thr Gly Asp Arg 
        275                 280                 285             


Leu Leu Asn Leu Val Glu Gly Ala Tyr Leu Ala Leu Asn Leu Thr Ser 
    290                 295                 300                 


Pro Asp Lys Thr Gln Glu Cys Trp Leu Cys Leu Val Ser Gly Pro Pro 
305                 310                 315                 320 


Tyr Tyr Glu Gly Val Ala Val Leu Gly Thr Tyr Ser Asn His Thr Ser 
                325                 330                 335     


Ala Pro Ala Asn Cys Ser Val Thr Ser Gln His Lys Leu Thr Leu Ser 
            340                 345                 350         


Glu Val Thr Gly Gln Gly Leu Cys Ile Gly Ala Val Pro Lys Thr His 
        355                 360                 365             


Gln Ala Leu Cys Asn Thr Thr Gln Lys Thr Ser Asp Gly Ser Tyr Tyr 
    370                 375                 380                 


Leu Ala Ser Pro Ala Gly Thr Ile Trp Ala Cys Ser Thr Gly Leu Thr 
385                 390                 395                 400 


Pro Cys Leu Ser Thr Thr Val Leu Asn Leu Thr Thr Asp Tyr Cys Val 
                405                 410                 415     


Leu Val Glu Leu Trp Pro Lys Val Thr Tyr His Ser Pro Asn Tyr Val 
            420                 425                 430         


Tyr Gly Gln Phe Glu Lys Lys Thr Lys Tyr Lys Arg Glu Pro Val Ser 
        435                 440                 445             


Leu Thr Leu Ala Leu Leu Leu Gly Gly Leu Thr Met Gly Gly Ile Ala 
    450                 455                 460                 


Ala Gly Val Gly Thr Gly Thr Thr Ala Leu Val Ala Thr Lys Gln Phe 
465                 470                 475                 480 


Glu Gln Leu Gln Ala Ala Ile His Thr Asp Leu Gly Ala Leu Glu Lys 
                485                 490                 495     


Ser Val Ser Ala Leu Glu Lys Ser Leu Thr Ser Leu Ser Glu Val Val 
            500                 505                 510         


Leu Gln Asn Arg Arg Gly Leu Asp Leu Leu Phe Leu Lys Glu Gly Gly 
        515                 520                 525             


Leu Cys Ala Ala Leu Lys Glu Glu Cys Cys Phe Tyr Ala Asp His Thr 
    530                 535                 540                 


Gly Val Val Arg Asp Ser Met Ala Lys Leu Arg Glu Arg Leu Asn Gln 
545                 550                 555                 560 


Arg Gln Lys Leu Phe Glu Ser Gly Gln Gly Trp Phe Glu Gly Leu Phe 
                565                 570                 575     


Asn Arg Ser Pro Trp Phe Thr Thr Leu Ile Ser Thr Ile Met Gly Pro 
            580                 585                 590         


Leu Ile Val Leu Leu Leu Ile Leu Leu Phe Gly Pro Cys Ile Leu Asn 
        595                 600                 605             


Arg Leu Val Gln Phe Val Lys Asp Arg Ile Ser Val Val Gln Ala Leu 
    610                 615                 620                 


Val Leu Thr Gln Gln Tyr His Gln Leu Lys Ser Ile Asp Pro Glu Glu 
625                 630                 635                 640 


Val Glu Ser Arg Glu 
                645 


<210>  199
<211>  885
<212>  PRT
<213>  Simian immunodeficiency virus

<400>  199

Met Gly Cys Leu Gly Asn Gln Leu Leu Ile Ala Leu Leu Leu Val Ser 
1               5                   10                  15      


Val Leu Glu Ile Cys Cys Val Gln Tyr Val Thr Val Phe Tyr Gly Val 
            20                  25                  30          


Pro Ala Trp Lys Asn Ala Thr Ile Pro Leu Phe Cys Ala Thr Lys Asn 
        35                  40                  45              


Arg Asp Thr Trp Gly Thr Thr Gln Cys Leu Pro Asp Asn Asp Asp Tyr 
    50                  55                  60                  


Ser Glu Leu Ala Ile Asn Val Thr Glu Ala Phe Asp Ala Trp Asp Asn 
65                  70                  75                  80  


Thr Val Thr Glu Gln Ala Ile Glu Asp Val Trp Asn Leu Phe Glu Thr 
                85                  90                  95      


Ser Ile Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Ile Ala Met Arg 
            100                 105                 110         


Cys Asn Lys Thr Glu Thr Asp Arg Trp Gly Leu Thr Gly Asn Ala Gly 
        115                 120                 125             


Thr Thr Thr Thr Ala Ile Thr Thr Thr Ala Thr Pro Ser Val Ala Glu 
    130                 135                 140                 


Asn Val Ile Asn Glu Ser Asn Pro Cys Ile Lys Asn Asn Ser Cys Ala 
145                 150                 155                 160 


Gly Leu Glu Gln Glu Pro Met Ile Gly Cys Lys Phe Asn Met Thr Gly 
                165                 170                 175     


Leu Asn Arg Asp Lys Lys Lys Glu Tyr Asn Glu Thr Trp Tyr Ser Arg 
            180                 185                 190         


Asp Leu Ile Cys Glu Gln Ser Ala Asn Glu Ser Glu Ser Lys Cys Tyr 
        195                 200                 205             


Met His His Cys Asn Thr Ser Val Ile Gln Glu Ser Cys Asp Lys His 
    210                 215                 220                 


Tyr Trp Asp Ala Ile Arg Phe Arg Tyr Cys Ala Pro Pro Gly Tyr Ala 
225                 230                 235                 240 


Leu Leu Arg Cys Asn Asp Ser Asn Tyr Leu Gly Phe Ala Pro Asn Cys 
                245                 250                 255     


Ser Lys Val Val Val Ser Ser Cys Thr Arg Met Met Glu Thr Gln Thr 
            260                 265                 270         


Ser Thr Trp Phe Gly Phe Asn Gly Thr Arg Ala Glu Asn Arg Thr Tyr 
        275                 280                 285             


Ile Tyr Trp His Gly Lys Ser Asn Arg Thr Ile Ile Ser Leu Asn Lys 
    290                 295                 300                 


Tyr Tyr Asn Leu Thr Met Arg Cys Arg Arg Pro Glu Asn Lys Thr Val 
305                 310                 315                 320 


Leu Pro Val Thr Ile Met Ser Gly Leu Val Phe His Ser Gln Pro Ile 
                325                 330                 335     


Asn Glu Arg Pro Lys Gln Ala Trp Cys Trp Phe Glu Gly Ser Trp Lys 
            340                 345                 350         


Lys Ala Ile Gln Glu Val Lys Glu Thr Leu Val Lys His Pro Arg Tyr 
        355                 360                 365             


Thr Gly Thr Asn Asp Thr Arg Lys Ile Asn Leu Thr Ala Pro Ala Gly 
    370                 375                 380                 


Gly Asp Pro Glu Val Thr Phe Met Trp Thr Asn Cys Arg Gly Glu Phe 
385                 390                 395                 400 


Leu Tyr Cys Lys Met Asn Trp Phe Leu Asn Trp Val Glu Asp Arg Asp 
                405                 410                 415     


Gln Lys Gly Gly Arg Trp Lys Gln Gln Asn Arg Lys Glu Gln Gln Lys 
            420                 425                 430         


Lys Asn Tyr Val Pro Cys His Ile Arg Gln Ile Ile Asn Thr Trp His 
        435                 440                 445             


Lys Val Gly Lys Asn Val Tyr Leu Pro Pro Arg Glu Gly Asp Leu Thr 
    450                 455                 460                 


Cys Asn Ser Thr Val Thr Ser Leu Ile Ala Glu Ile Asp Trp Ile Asn 
465                 470                 475                 480 


Ser Asn Glu Thr Asn Ile Thr Met Ser Ala Glu Val Ala Glu Leu Tyr 
                485                 490                 495     


Arg Leu Glu Leu Gly Asp Tyr Lys Leu Ile Glu Ile Thr Pro Ile Gly 
            500                 505                 510         


Leu Ala Pro Thr Ser Val Arg Arg Tyr Thr Thr Thr Gly Ala Ser Arg 
        515                 520                 525             


Asn Lys Arg Gly Val Phe Val Leu Gly Phe Leu Gly Phe Leu Ala Thr 
    530                 535                 540                 


Ala Gly Ser Ala Met Gly Ala Ala Ser Val Thr Leu Ser Ala Gln Ser 
545                 550                 555                 560 


Arg Thr Leu Leu Ala Gly Ile Val Gln Gln Gln Gln Gln Leu Leu Asp 
                565                 570                 575     


Val Val Lys Arg Gln Gln Glu Leu Leu Arg Leu Thr Val Trp Gly Thr 
            580                 585                 590         


Lys Asn Leu Gln Thr Arg Val Thr Ala Ile Glu Lys Tyr Leu Lys Asp 
        595                 600                 605             


Gln Ala Gln Leu Asn Ser Trp Gly Cys Ala Phe Arg Gln Val Cys His 
    610                 615                 620                 


Thr Thr Val Pro Trp Pro Asn Glu Thr Leu Val Pro Asn Trp Asn Asn 
625                 630                 635                 640 


Met Thr Trp Gln Glu Trp Glu Arg Gln Val Asp Phe Leu Glu Ala Asn 
                645                 650                 655     


Ile Thr Gln Leu Leu Glu Glu Ala Gln Ile Gln Gln Glu Lys Asn Met 
            660                 665                 670         


Tyr Glu Leu Gln Lys Leu Asn Ser Trp Asp Ile Phe Gly Asn Trp Phe 
        675                 680                 685             


Asp Leu Thr Ser Trp Ile Arg Tyr Ile Gln Tyr Gly Val Leu Ile Val 
    690                 695                 700                 


Leu Gly Val Ile Gly Leu Arg Ile Val Ile Tyr Val Val Gln Met Leu 
705                 710                 715                 720 


Ala Arg Leu Arg Gln Gly Tyr Arg Pro Val Phe Ser Ser Pro Pro Ala 
                725                 730                 735     


Tyr Val Gln Gln Ile Pro Ile His Lys Gly Gln Glu Pro Pro Thr Lys 
            740                 745                 750         


Glu Gly Glu Glu Gly Asp Gly Gly Asp Arg Gly Gly Ser Arg Ser Trp 
        755                 760                 765             


Pro Trp Gln Ile Glu Tyr Ile His Phe Leu Ile Arg Gln Leu Ile Arg 
    770                 775                 780                 


Leu Leu Thr Trp Leu Phe Ser Ser Cys Arg Asp Trp Leu Leu Arg Ser 
785                 790                 795                 800 


Tyr Gln Ile Leu Gln Pro Val Leu Gln Ser Leu Ser Thr Thr Leu Gln 
                805                 810                 815     


Arg Val Arg Glu Val Ile Arg Ile Glu Ile Ala Tyr Leu Gln Tyr Gly 
            820                 825                 830         


Trp Arg Tyr Phe Gln Glu Ala Val Gln Ala Trp Trp Lys Leu Ala Arg 
        835                 840                 845             


Glu Thr Leu Ala Ser Ala Trp Gly Asp Ile Trp Glu Thr Leu Gly Arg 
    850                 855                 860                 


Val Gly Arg Gly Ile Leu Ala Ile Pro Arg Arg Ile Arg Gln Gly Leu 
865                 870                 875                 880 


Glu Leu Thr Leu Leu 
                885 


<210>  200
<211>  881
<212>  PRT
<213>  Simian immunodeficiency virus


<220>
<221>  misc_feature
<222>  (736)..(736)
<223>  Xaa can be any naturally occurring amino acid

<400>  200

Met Gly Cys Leu Gly Asn Gln Leu Leu Ile Ala Ile Leu Leu Leu Ser 
1               5                   10                  15      


Val Tyr Gly Ile Tyr Cys Thr Gln Tyr Val Thr Val Phe Tyr Gly Val 
            20                  25                  30          


Pro Ala Trp Arg Asn Ala Thr Ile Pro Leu Phe Cys Ala Thr Lys Asn 
        35                  40                  45              


Arg Asp Thr Trp Gly Thr Thr Gln Cys Leu Pro Asp Asn Gly Asp Tyr 
    50                  55                  60                  


Ser Glu Leu Ala Leu Asn Val Thr Glu Ser Phe Asp Ala Trp Glu Asn 
65                  70                  75                  80  


Thr Val Thr Glu Gln Ala Ile Glu Asp Val Trp Gln Leu Phe Glu Thr 
                85                  90                  95      


Ser Ile Lys Pro Cys Val Lys Leu Ser Pro Leu Cys Ile Thr Met Arg 
            100                 105                 110         


Cys Asn Lys Ser Glu Thr Asp Arg Trp Gly Leu Thr Lys Ser Ser Thr 
        115                 120                 125             


Thr Ile Thr Thr Ala Ala Pro Thr Ser Ala Pro Val Ser Glu Lys Ile 
    130                 135                 140                 


Asp Met Val Asn Glu Thr Ser Ser Cys Ile Ala Gln Asn Asn Cys Thr 
145                 150                 155                 160 


Gly Leu Glu Gln Glu Gln Met Ile Ser Cys Lys Phe Thr Met Thr Gly 
                165                 170                 175     


Leu Lys Arg Asp Lys Thr Lys Glu Tyr Asn Glu Thr Trp Tyr Ser Thr 
            180                 185                 190         


Asp Leu Val Cys Glu Gln Gly Asn Ser Thr Asp Asn Glu Ser Arg Cys 
        195                 200                 205             


Tyr Met Asn His Cys Asn Thr Ser Val Ile Gln Glu Ser Cys Asp Lys 
    210                 215                 220                 


His Tyr Trp Asp Thr Ile Arg Phe Arg Tyr Cys Ala Pro Pro Gly Tyr 
225                 230                 235                 240 


Ala Leu Leu Arg Cys Asn Asp Thr Asn Tyr Ser Gly Phe Met Pro Lys 
                245                 250                 255     


Cys Ser Lys Val Val Val Ser Ser Cys Thr Arg Met Met Glu Thr Gln 
            260                 265                 270         


Thr Ser Thr Trp Phe Gly Phe Asn Gly Thr Arg Ala Glu Asn Arg Thr 
        275                 280                 285             


Tyr Ile Tyr Trp His Gly Arg Asp Asn Arg Thr Ile Ile Ser Leu Asn 
    290                 295                 300                 


Lys Tyr Tyr Asn Leu Thr Met Lys Cys Arg Arg Pro Gly Asn Lys Thr 
305                 310                 315                 320 


Val Leu Pro Val Thr Ile Met Ser Gly Leu Val Phe His Ser Gln Pro 
                325                 330                 335     


Ile Asn Asp Arg Pro Lys Gln Ala Trp Cys Trp Phe Gly Gly Lys Trp 
            340                 345                 350         


Lys Asp Ala Ile Lys Glu Val Lys Gln Thr Ile Val Lys His Pro Arg 
        355                 360                 365             


Tyr Thr Gly Thr Asn Asn Thr Asp Lys Ile Asn Leu Thr Ala Pro Gly 
    370                 375                 380                 


Gly Gly Asp Pro Glu Val Thr Phe Met Trp Thr Asn Cys Arg Gly Glu 
385                 390                 395                 400 


Phe Leu Tyr Cys Lys Met Asn Trp Phe Leu Asn Trp Val Glu Asp Arg 
                405                 410                 415     


Asp Val Thr Thr Gln Arg Pro Lys Glu Arg His Arg Arg Asn Tyr Val 
            420                 425                 430         


Pro Cys His Ile Arg Gln Ile Ile Asn Thr Trp His Lys Val Gly Lys 
        435                 440                 445             


Asn Val Tyr Leu Pro Pro Arg Glu Gly Asp Leu Thr Cys Asn Ser Thr 
    450                 455                 460                 


Val Thr Ser Leu Ile Ala Asn Ile Asp Trp Thr Asp Gly Asn Gln Thr 
465                 470                 475                 480 


Ser Ile Thr Met Ser Ala Glu Val Ala Glu Leu Tyr Arg Leu Glu Leu 
                485                 490                 495     


Gly Asp Tyr Lys Leu Val Glu Ile Thr Pro Ile Gly Leu Ala Pro Thr 
            500                 505                 510         


Asp Val Lys Arg Tyr Thr Thr Gly Gly Thr Ser Arg Asn Lys Arg Gly 
        515                 520                 525             


Val Phe Val Leu Gly Phe Leu Gly Phe Leu Ala Thr Ala Gly Ser Ala 
    530                 535                 540                 


Met Gly Ala Ala Ser Leu Thr Leu Thr Ala Gln Ser Arg Thr Leu Leu 
545                 550                 555                 560 


Ala Gly Ile Val Gln Gln Gln Gln Gln Leu Leu Asp Val Val Lys Arg 
                565                 570                 575     


Gln Gln Glu Leu Leu Arg Leu Thr Val Trp Gly Thr Lys Asn Leu Gln 
            580                 585                 590         


Thr Arg Val Thr Ala Ile Glu Lys Tyr Leu Lys Asp Gln Ala Gln Leu 
        595                 600                 605             


Asn Ala Trp Gly Cys Ala Phe Arg Gln Val Cys His Thr Thr Val Pro 
    610                 615                 620                 


Trp Pro Asn Ala Ser Leu Thr Pro Asp Trp Asn Asn Asp Thr Trp Gln 
625                 630                 635                 640 


Glu Trp Glu Arg Lys Val Asp Phe Leu Glu Glu Asn Ile Thr Ala Leu 
                645                 650                 655     


Leu Glu Glu Ala Gln Ile Gln Gln Glu Lys Asn Met Tyr Glu Leu Gln 
            660                 665                 670         


Lys Leu Asn Ser Trp Asp Val Phe Gly Asn Trp Phe Asp Leu Ala Ser 
        675                 680                 685             


Trp Ile Lys Tyr Ile Gln Tyr Gly Ile Tyr Val Val Val Gly Val Ile 
    690                 695                 700                 


Leu Leu Arg Ile Val Ile Tyr Ile Val Gln Met Leu Ala Lys Leu Arg 
705                 710                 715                 720 


Gln Gly Tyr Arg Pro Val Phe Ser Ser Pro Pro Ser Tyr Phe Gln Xaa 
                725                 730                 735     


Thr His Thr Gln Gln Asp Pro Ala Leu Pro Thr Arg Glu Gly Lys Glu 
            740                 745                 750         


Gly Asp Gly Gly Glu Gly Gly Gly Asn Ser Ser Trp Pro Trp Gln Ile 
        755                 760                 765             


Glu Tyr Ile His Phe Leu Ile Arg Gln Leu Ile Arg Leu Leu Thr Trp 
    770                 775                 780                 


Leu Phe Ser Asn Cys Arg Thr Leu Leu Ser Arg Ala Tyr Gln Ile Leu 
785                 790                 795                 800 


Gln Pro Ile Leu Gln Arg Leu Ser Ala Thr Leu Arg Arg Val Arg Glu 
                805                 810                 815     


Val Leu Arg Thr Glu Leu Thr Tyr Leu Gln Tyr Gly Trp Ser Tyr Phe 
            820                 825                 830         


His Glu Ala Val Gln Ala Gly Trp Arg Ser Ala Thr Glu Thr Leu Ala 
        835                 840                 845             


Gly Ala Trp Arg Asp Leu Trp Glu Thr Leu Arg Arg Gly Gly Arg Trp 
    850                 855                 860                 


Ile Leu Ala Ile Pro Arg Arg Ile Arg Gln Gly Leu Glu Leu Thr Leu 
865                 870                 875                 880 


Leu 
    


<210>  201
<211>  821
<212>  PRT
<213>  Simian immunodeficiency virus

<400>  201

Met Ser Thr Gly Asn Val Tyr Gln Glu Leu Ile Arg Arg Tyr Leu Val 
1               5                   10                  15      


Val Val Lys Lys Leu Tyr Glu Gly Lys Tyr Glu Val Ser Arg Ser Phe 
            20                  25                  30          


Ser Tyr Thr Met Phe Ser Leu Leu Val Gly Ile Ile Gly Lys Gln Tyr 
        35                  40                  45              


Val Thr Val Phe Tyr Gly Val Pro Val Trp Lys Glu Ala Lys Thr His 
    50                  55                  60                  


Leu Ile Cys Ala Thr Asp Asn Ser Ser Leu Trp Val Thr Thr Asn Cys 
65                  70                  75                  80  


Ile Pro Ser Leu Pro Asp Tyr Asp Glu Val Glu Ile Pro Asp Ile Lys 
                85                  90                  95      


Glu Asn Phe Thr Gly Leu Ile Arg Glu Asn Gln Ile Val Tyr Gln Ala 
            100                 105                 110         


Trp His Ala Met Gly Ser Met Leu Asp Thr Ile Leu Lys Pro Cys Val 
        115                 120                 125             


Lys Ile Asn Pro Tyr Cys Val Lys Met Gln Cys Gln Glu Thr Glu Asn 
    130                 135                 140                 


Val Ser Ala Thr Thr Ala Lys Pro Ile Thr Thr Pro Thr Thr Thr Ser 
145                 150                 155                 160 


Thr Val Ala Ser Ser Thr Glu Ile Tyr Leu Asp Val Asp Lys Asn Asn 
                165                 170                 175     


Thr Glu Glu Lys Val Glu Arg Asn His Val Cys Arg Tyr Asn Ile Thr 
            180                 185                 190         


Gly Leu Cys Arg Asp Ser Lys Glu Glu Ile Val Thr Asn Phe Arg Gly 
        195                 200                 205             


Asp Asp Val Lys Cys Glu Asn Asn Thr Cys Tyr Met Asn His Cys Asn 
    210                 215                 220                 


Glu Ser Val Asn Thr Glu Asp Cys Gln Lys Gly Leu Leu Ile Arg Cys 
225                 230                 235                 240 


Ile Leu Gly Cys Val Pro Pro Gly Tyr Val Met Leu Arg Tyr Asn Glu 
                245                 250                 255     


Lys Leu Asn Asn Asn Lys Leu Cys Ser Asn Ile Ser Ala Val Gln Cys 
            260                 265                 270         


Thr Gln His Leu Val Ala Thr Val Ser Ser Phe Phe Gly Phe Asn Gly 
        275                 280                 285             


Thr Met His Lys Glu Gly Glu Leu Ile Pro Ile Asp Asp Lys Tyr Arg 
    290                 295                 300                 


Gly Pro Glu Glu Phe His Gln Arg Lys Phe Val Tyr Lys Val Pro Gly 
305                 310                 315                 320 


Lys Tyr Gly Leu Lys Ile Glu Cys His Arg Lys Gly Asn Arg Ser Val 
                325                 330                 335     


Val Ser Thr Pro Ser Ala Thr Gly Leu Leu Phe Tyr His Gly Leu Glu 
            340                 345                 350         


Pro Gly Lys Asn Leu Lys Lys Gly Met Cys Thr Phe Lys Gly Arg Trp 
        355                 360                 365             


Gly Leu Ala Leu Trp Ser Leu Ala Lys Glu Leu Asn Lys Leu Asn Asp 
    370                 375                 380                 


Ser Ile Lys Val Asn Gln Thr Cys Lys Asn Phe Thr Ser Thr Gly Glu 
385                 390                 395                 400 


Glu Asn Lys Gln Asn Thr Asp Lys Gln Lys Glu Phe Ala Lys Cys Ile 
                405                 410                 415     


Lys Thr Leu Lys Ile Asp Asn Tyr Thr Thr Ser Gly Asp Arg Ala Ala 
            420                 425                 430         


Glu Met Met Met Met Thr Cys Gln Gly Glu Met Phe Phe Cys Asn Val 
        435                 440                 445             


Thr Arg Ile Met Arg Ala Trp Asn Asp Pro Asn Glu Lys Lys Trp Tyr 
    450                 455                 460                 


Pro Tyr Ala Ser Cys Gln Ile Arg Gln Ile Val Asp Asp Trp Met Gln 
465                 470                 475                 480 


Val Gly Arg Lys Ile Tyr Leu Pro Pro Thr Ser Gly Phe Asn Asn His 
                485                 490                 495     


Ile Arg Cys Thr His Arg Val Thr Glu Met Tyr Phe Glu Met Gln Lys 
            500                 505                 510         


Ile Asp Ser Asn Glu Thr Lys Met Gln Ile Lys Phe Leu Pro Pro Ser 
        515                 520                 525             


Glu Thr Ser Asn Gln Phe Val Ala Tyr Gly Ala His Tyr Lys Leu Val 
    530                 535                 540                 


Lys Ile Met Pro Ile Gly Ile Ala Pro Thr Asp Val Lys Arg His Thr 
545                 550                 555                 560 


Leu Pro Glu His His Lys Glu Lys Arg Gly Ala Val Ile Leu Gly Ile 
                565                 570                 575     


Leu Gly Leu Leu Ser Leu Ala Gly Ser Ala Met Gly Ser Val Ser Val 
            580                 585                 590         


Ala Leu Thr Val Gln Ser Gln Ser Leu Val Thr Gly Ile Val Glu Gln 
        595                 600                 605             


Gln Lys Gln Leu Leu Lys Leu Ile Glu Gln Gln Ser Glu Leu Leu Lys 
    610                 615                 620                 


Leu Thr Ile Trp Gly Val Lys Asn Leu Gln Thr Arg Leu Thr Ser Leu 
625                 630                 635                 640 


Glu Asn Tyr Ile Lys Asp Gln Ala Leu Leu Ser Gln Trp Gly Cys Ser 
                645                 650                 655     


Trp Ala Gln Val Cys His Thr Ser Val Glu Trp Thr Asn Thr Ser Ile 
            660                 665                 670         


Thr Pro Asn Trp Thr Ser Glu Thr Trp Lys Glu Trp Glu Thr Arg Thr 
        675                 680                 685             


Asp Tyr Leu Gln Gln Asn Ile Thr Glu Met Leu Lys Gln Ala Tyr Asp 
    690                 695                 700                 


Arg Glu Gln Arg Asn Thr Tyr Glu Leu Gln Lys Leu Gly Asp Leu Thr 
705                 710                 715                 720 


Ser Trp Ala Ser Trp Phe Asp Phe Thr Trp Trp Val Gln Tyr Leu Lys 
                725                 730                 735     


Trp Gly Val Phe Leu Val Leu Gly Ile Ile Gly Leu Arg Ile Leu Leu 
            740                 745                 750         


Ala Leu Trp Asn Thr Ile Ser Arg Phe Arg Gln Gly Tyr Arg Pro Val 
        755                 760                 765             


Phe Ser Gln Asp Cys Gln Gln Asn Leu Tyr Arg Lys Arg Pro Asp Asn 
    770                 775                 780                 


Gly Glu Glu Glu Ser Asn Ser Leu Glu Leu Gly Glu His Asn Ser Glu 
785                 790                 795                 800 


Asn Leu Lys Glu Glu Ser Leu Asn Arg Ser Leu Ile Glu Asp Leu Thr 
                805                 810                 815     


Ser Phe Ala Arg Glu 
            820     


<210>  202
<211>  882
<212>  PRT
<213>  Simian immunodeficiency virus


<220>
<221>  misc_feature
<222>  (737)..(737)
<223>  Xaa can be any naturally occurring amino acid

<400>  202

Met Gly Cys Leu Gly Asn Gln Leu Leu Ile Ala Ile Leu Leu Leu Ser 
1               5                   10                  15      


Val Tyr Gly Ile Tyr Cys Ile Gln Tyr Val Thr Val Phe Tyr Gly Val 
            20                  25                  30          


Pro Ala Trp Arg Asn Ala Thr Ile Pro Leu Phe Cys Ala Thr Lys Asn 
        35                  40                  45              


Arg Asp Thr Trp Gly Thr Thr Gln Cys Leu Pro Asp Asn Asp Asp Tyr 
    50                  55                  60                  


Ser Glu Leu Ala Leu Asn Val Thr Glu Ser Phe Asp Ala Trp Glu Asn 
65                  70                  75                  80  


Thr Val Thr Glu Gln Ala Ile Glu Asp Val Trp Gln Leu Phe Glu Thr 
                85                  90                  95      


Ser Ile Lys Pro Cys Val Lys Leu Ser Pro Leu Cys Ile Thr Met Arg 
            100                 105                 110         


Cys Asn Lys Ser Glu Thr Asp Lys Trp Gly Leu Thr Lys Ser Ser Thr 
        115                 120                 125             


Thr Thr Ala Ser Thr Thr Thr Thr Thr Thr Ala Lys Ser Val Glu Thr 
    130                 135                 140                 


Arg Asp Ile Val Asn Glu Thr Ser Pro Cys Val Val His Asp Asn Cys 
145                 150                 155                 160 


Thr Gly Leu Glu Gln Glu Pro Met Ile Ser Cys Lys Phe Asn Met Thr 
                165                 170                 175     


Gly Leu Lys Arg Asp Lys Lys Lys Glu Tyr Asn Glu Thr Trp Tyr Ser 
            180                 185                 190         


Ala Asp Leu Val Cys Glu Gln Gly Asn Ser Thr Gly Asn Glu Ser Arg 
        195                 200                 205             


Cys Tyr Met Asn His Cys Asn Thr Ser Val Ile Gln Glu Cys Cys Asp 
    210                 215                 220                 


Lys Asp Tyr Trp Asp Ala Ile Arg Cys Arg Tyr Cys Ala Pro Pro Gly 
225                 230                 235                 240 


Tyr Ala Leu Leu Arg Cys Asn Asp Thr Asn Tyr Ser Gly Phe Met Pro 
                245                 250                 255     


Asn Cys Ser Lys Val Val Val Ser Ser Cys Thr Arg Met Met Glu Thr 
            260                 265                 270         


Gln Thr Ser Thr Trp Phe Arg Phe Asn Gly Thr Arg Ala Glu Asn Arg 
        275                 280                 285             


Thr Tyr Ile Tyr Trp His Gly Arg Asp Asn Arg Thr Ile Ile Ser Leu 
    290                 295                 300                 


Asn Lys His Tyr Asn Leu Thr Met Lys Cys Arg Arg Pro Gly Asn Lys 
305                 310                 315                 320 


Thr Val Leu Pro Val Thr Ile Met Ser Ala Leu Val Phe His Ser Gln 
                325                 330                 335     


Pro Val Asn Glu Arg Pro Lys Gln Ala Trp Cys Arg Phe Gly Gly Asn 
            340                 345                 350         


Trp Lys Glu Ala Ile Lys Glu Val Lys Gln Thr Ile Val Lys His Pro 
        355                 360                 365             


Arg Tyr Thr Gly Thr Asn Asn Thr Asp Lys Ile Asn Leu Thr Ala Pro 
    370                 375                 380                 


Arg Gly Gly Asp Pro Glu Val Thr Phe Met Trp Thr Asn Cys Arg Gly 
385                 390                 395                 400 


Glu Phe Leu Tyr Cys Lys Met Asn Trp Phe Leu Asn Trp Val Glu Asp 
                405                 410                 415     


Arg Ser Leu Thr Thr Gln Lys Pro Lys Glu Arg His Lys Arg Asn Tyr 
            420                 425                 430         


Val Pro Cys His Ile Arg Gln Ile Ile Asn Thr Trp His Lys Val Gly 
        435                 440                 445             


Lys Asn Val Tyr Leu Pro Pro Arg Glu Gly Asp Leu Thr Cys Asn Ser 
    450                 455                 460                 


Thr Val Thr Ser Leu Ile Ala Asn Ile Asn Trp Thr Asp Gly Asn Gln 
465                 470                 475                 480 


Thr Ser Ile Thr Met Ser Ala Glu Val Ala Glu Leu Tyr Arg Leu Glu 
                485                 490                 495     


Leu Gly Asp Tyr Lys Leu Val Glu Ile Thr Pro Ile Gly Leu Ala Pro 
            500                 505                 510         


Thr Asn Val Lys Arg Tyr Thr Thr Gly Gly Thr Ser Arg Asn Lys Arg 
        515                 520                 525             


Gly Val Phe Val Leu Gly Phe Leu Gly Phe Leu Ala Thr Ala Gly Ser 
    530                 535                 540                 


Ala Met Gly Ala Ala Ser Leu Thr Val Thr Ala Gln Ser Arg Thr Leu 
545                 550                 555                 560 


Leu Ala Gly Ile Val Gln Gln Gln Gln Gln Leu Leu Asp Val Val Lys 
                565                 570                 575     


Arg Gln Gln Glu Leu Leu Arg Leu Thr Val Trp Gly Thr Lys Asn Leu 
            580                 585                 590         


Gln Thr Arg Val Ser Ala Ile Glu Lys Tyr Leu Lys Asp Gln Ala Gln 
        595                 600                 605             


Leu Asn Ala Trp Gly Cys Ala Phe Arg Gln Val Cys His Thr Thr Val 
    610                 615                 620                 


Pro Trp Pro Asn Ala Ser Leu Thr Pro Asp Trp Asn Asn Glu Thr Trp 
625                 630                 635                 640 


Gln Glu Trp Glu Arg Lys Val Asp Phe Leu Glu Ala Asn Ile Thr Ala 
                645                 650                 655     


Leu Leu Glu Glu Ala Gln Ile Gln Gln Glu Lys Asn Met Tyr Glu Leu 
            660                 665                 670         


Gln Lys Leu Asn Ser Trp Asp Val Phe Gly Asn Trp Phe Asp Leu Thr 
        675                 680                 685             


Ser Trp Ile Lys Tyr Ile Gln Tyr Gly Ile Tyr Ile Ile Val Gly Val 
    690                 695                 700                 


Ile Leu Leu Arg Ile Val Ile Tyr Ile Val Gln Met Leu Ala Arg Leu 
705                 710                 715                 720 


Arg Gln Gly Tyr Arg Pro Val Phe Ser Ser Pro Pro Ser Tyr Phe Gln 
                725                 730                 735     


Xaa Thr His Thr Gln Gln Asp Pro Ala Leu Pro Thr Lys Glu Gly Lys 
            740                 745                 750         


Lys Gly Asp Gly Gly Gly Ser Gly Gly Asn Ser Ser Trp Pro Trp Gln 
        755                 760                 765             


Ile Glu Tyr Ile His Phe Leu Ile Arg Gln Leu Ile Arg Leu Leu Thr 
    770                 775                 780                 


Trp Leu Phe Ser Asn Cys Arg Thr Leu Leu Ser Arg Ala Tyr Gln Ile 
785                 790                 795                 800 


Leu Gln Pro Ile Phe Gln Arg Leu Ser Ala Thr Leu Arg Arg Ile Arg 
                805                 810                 815     


Glu Val Leu Arg Leu Glu Leu Thr Tyr Leu Gln Tyr Gly Trp Ser Tyr 
            820                 825                 830         


Phe Gln Glu Ala Val Gln Ala Ala Gln Arg Ser Ala Thr Glu Thr Leu 
        835                 840                 845             


Ala Gly Ala Trp Gly Glu Leu Trp Glu Ala Leu Gln Arg Gly Gly Arg 
    850                 855                 860                 


Trp Ile Leu Ala Ile Pro Arg Arg Ile Arg Gln Gly Leu Glu Leu Thr 
865                 870                 875                 880 


Leu Leu 
        


<210>  203
<211>  880
<212>  PRT
<213>  Simian immunodeficiency virus

<400>  203

Met Lys Ala Met Glu Thr Gln Arg Asn Cys Arg Thr Leu Ser Leu Lys 
1               5                   10                  15      


Glu Ile Ile Leu Cys Thr Leu Val Leu Gly Ile Ile Gly Ile Ile Lys 
            20                  25                  30          


Cys Glu Asp Asn Met Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp 
        35                  40                  45              


Arg Glu Ala Asp Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Gln 
    50                  55                  60                  


Asn Pro Glu Val His Asn Val Trp Ala Ser Gln Ala Cys Val Ser Thr 
65                  70                  75                  80  


Asn Pro Asn Pro Glu Glu Ile Glu Leu Thr Asn Val Thr Glu Tyr Phe 
                85                  90                  95      


Asn Ala Trp Glu Asn Asn Met Val Glu Gln Met His Glu Asp Ile Val 
            100                 105                 110         


Asn Leu Trp Asp Gln Ser Val Lys Pro Cys Val Lys Leu Ile Pro Leu 
        115                 120                 125             


Cys Val Thr Leu Asn Cys Ser Leu Phe Lys Cys Ile Lys Glu Asn Gly 
    130                 135                 140                 


Asn Thr Thr Asn Cys Thr Val Gln Ile Ser Thr Gly Asn Asp Ser Thr 
145                 150                 155                 160 


Ala Asn Asn Ile Thr Val Gly Thr Ile Asp Met Tyr Asn Cys Ser Phe 
                165                 170                 175     


Asn Ala Thr Thr Glu Leu Arg Asp Arg Lys Lys Gln Val Tyr Ser Leu 
            180                 185                 190         


Phe Tyr Arg Gln Asp Leu Glu Pro Leu Glu Gly Asn Lys Pro Pro Glu 
        195                 200                 205             


Gly Asp Lys Asn Ala Leu Tyr Arg Leu Tyr Asn Cys Asn Thr Thr Ala 
    210                 215                 220                 


Met Thr Gln Ala Cys Ser Lys Val Ser Leu Glu Pro Ile Pro Ile His 
225                 230                 235                 240 


Tyr Cys Ala Pro Ala Gly Phe Ala Leu Leu Lys Cys Asn Asp Lys Asn 
                245                 250                 255     


Phe Thr Gly Ile Gly Gln Cys Lys Asn Val Ser Thr Val His Cys Thr 
            260                 265                 270         


His Gly Ile Arg Pro Val Val Ser Thr Gln Phe Leu Leu Asn Gly Thr 
        275                 280                 285             


Leu Glu Glu Lys Val Thr Val Leu Asp Arg Asn Val Ser Asn Asp Met 
    290                 295                 300                 


Asp Thr Ile Ile Val Lys Leu Asn Glu Thr Val Arg Leu Asn Cys Thr 
305                 310                 315                 320 


Arg Thr Gly Asn Asn Thr Ile Lys Gly Ile Pro Ile Gly Pro Ser Gln 
                325                 330                 335     


Ile Phe Tyr Gly Ile Glu Thr Val Ile Gly Asp Thr Arg Gln Ala Phe 
            340                 345                 350         


Cys Gln Leu Asn Lys Thr Val Trp Thr Asn Thr Phe Lys Lys Val Arg 
        355                 360                 365             


His Ala Leu Asn Glu Thr Tyr Lys Gly Tyr Leu Gly Asn Glu Thr Ile 
    370                 375                 380                 


Thr Phe Gly Pro Ser Thr Gly Gly Asp Leu Glu Val Thr Asn Leu His 
385                 390                 395                 400 


Leu Ile Cys Gly Gly Glu Phe Phe Tyr Cys Asn Thr Ser Ile Leu Phe 
                405                 410                 415     


Asn Thr Ser Ile Ile Phe Asn Glu Thr Lys Asp Asp Asn Ile Thr Ile 
            420                 425                 430         


Pro Cys Arg Ile Arg Gln Ile Val Arg Leu Trp Gln Arg Val Gly Arg 
        435                 440                 445             


Gly Ile Phe Leu Pro Pro Ile Arg Gly Thr Ile Asn Cys Ile Ser Asn 
    450                 455                 460                 


Ile Thr Gly Ile Leu Phe Ala Gln Gln Lys Thr Asp Arg Met Asn Lys 
465                 470                 475                 480 


Ser Ala Met Phe Thr Pro Val Gly Gly Glu Met Arg Asn Asn Trp Arg 
                485                 490                 495     


Ser Glu Leu Tyr Lys Tyr Lys Val Val Arg Ile Glu Pro Leu Gly Val 
            500                 505                 510         


Ala Pro Thr Lys Ala Lys Arg Arg Thr Val His Arg Glu Lys Arg Ala 
        515                 520                 525             


Ala Val Gly Leu Gly Ala Leu Phe Leu Gly Phe Leu Gly Ala Ala Gly 
    530                 535                 540                 


Ser Thr Met Gly Ala Ala Ser Leu Thr Leu Thr Val Gln Ala Arg Gln 
545                 550                 555                 560 


Leu Leu Ser Gly Ile Val Gln Gln Gln Ser Asn Leu Leu Arg Ala Ile 
                565                 570                 575     


Glu Ala Gln Gln His Leu Leu Gln Leu Ser Val Trp Gly Ile Lys Gln 
            580                 585                 590         


Leu Gln Ala Arg Val Leu Ala Val Glu Arg Tyr Leu Lys Asp Gln Gln 
        595                 600                 605             


Leu Leu Gly Leu Trp Gly Cys Ser Gly Lys Leu Ile Cys Thr Thr Ser 
    610                 615                 620                 


Val Pro Trp Asn Thr Thr Trp Thr Asn Lys Ser Tyr Asp Asp Ile Trp 
625                 630                 635                 640 


Tyr Asn Met Thr Trp Met Gln Trp Asp Lys Glu Val Ser Asn Tyr Thr 
                645                 650                 655     


Asp Val Ile Tyr Asn Leu Leu Glu Lys Ala Gln Thr Gln Gln Glu Asn 
            660                 665                 670         


Asn Glu Lys Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn 
        675                 680                 685             


Trp Phe Asp Ile Thr Ser Trp Leu Trp Tyr Ile Lys Ile Phe Ile Ile 
    690                 695                 700                 


Ile Val Gly Gly Leu Ile Gly Leu Arg Ile Val Phe Ala Leu Leu Ser 
705                 710                 715                 720 


Ile Val Asn Arg Val Arg Gln Gly Tyr Ser Pro Leu Ser Phe Gln Thr 
                725                 730                 735     


Leu Ile Pro Ala Arg Arg Asp Arg Asp Arg Pro Glu Glu Ile Glu Glu 
            740                 745                 750         


Gly Gly Gly Glu Pro Asp Asn Val Arg Ser Ile Arg Leu Val Ser Gly 
        755                 760                 765             


Phe Leu Ala Leu Ala Trp Asn Asp Leu Arg Asp Leu Cys Leu Phe Leu 
    770                 775                 780                 


Tyr His Arg Leu Arg Asp Leu Leu Leu Ile Val Leu Arg Thr Leu Glu 
785                 790                 795                 800 


Leu Val Gly Gln Thr Leu Leu Lys Gly Leu Arg Arg Gly Arg Glu Ala 
                805                 810                 815     


Leu Ile His Leu Arg Gly Ile Leu Gln Tyr Trp Gly Gln Glu Leu Lys 
            820                 825                 830         


Thr Ser Ala Ile Ser Leu Leu Asp Thr Thr Ala Ile Ala Val Ala Glu 
        835                 840                 845             


Gly Thr Asp Arg Ile Ile Glu Ile Ala Gln Arg Phe Gly Arg Gly Ile 
    850                 855                 860                 


Leu Asn Ile Pro Arg Arg Ile Arg Gln Gly Leu Glu Arg Ala Leu Leu 
865                 870                 875                 880 


<210>  204
<211>  835
<212>  PRT
<213>  Simian immunodeficiency virus

<400>  204

Met Lys Val Thr Glu Met Gln Lys Asn Trp Leu Ile Cys Cys Leu Leu 
1               5                   10                  15      


Ile Gly Leu Ile Lys Ile Ile Gly Ser Glu Leu Trp Val Thr Val Tyr 
            20                  25                  30          


Tyr Gly Val Pro Val Trp Arg Asp Ala Glu Thr Val Leu Phe Cys Ala 
        35                  40                  45              


Ser Asp Ala Lys Ala His Ser Thr Glu Ala His Asn Ile Trp Ala Thr 
    50                  55                  60                  


Gln Ala Cys Val Pro Thr Asp Pro Asn Pro Gln Glu Val Leu Ile Pro 
65                  70                  75                  80  


Asn Val Thr Glu Arg Phe Asp Met Trp Lys Asn Asn Met Val Asp Gln 
                85                  90                  95      


Met Gln Glu Asp Ile Ile Ser Leu Trp Glu Gln Ser Leu Lys Pro Cys 
            100                 105                 110         


Val Lys Leu Thr Pro Leu Cys Val Thr Leu Ser Cys Ser Ser Trp Arg 
        115                 120                 125             


Ser Val Asn Asn Ser Val Asn Gln Thr Asn His Val Gln Met Gln Asn 
    130                 135                 140                 


Cys Ser Phe Asn Val Thr Thr Glu Leu Arg Asp Lys Lys Lys Gln Val 
145                 150                 155                 160 


Tyr Ser Leu Phe Tyr Met Gly Asp Ile Ile Pro Leu Asp Thr Asn Asn 
                165                 170                 175     


Ser Ser Gly Asn Asn Ser Gln Tyr Arg Leu Ile Asn Cys Asn Thr Thr 
            180                 185                 190         


Ala Val Thr Gln Ala Cys Pro Lys Ile Ser Phe Glu Pro Ile Pro Ile 
        195                 200                 205             


Tyr Tyr Cys Ala Pro Pro Gly Phe Ala Ile Ile Lys Cys Asn Asp Gln 
    210                 215                 220                 


Asp Phe Asn Gly Thr Gly Glu Cys Asn Asn Val Ser Thr Val Gln Cys 
225                 230                 235                 240 


Thr His Gly Ile Lys Pro Val Ile Ser Thr Gln Leu Ile Leu Asn Gly 
                245                 250                 255     


Ser Leu Ala Thr Ser Asn Ile Val Ile Arg Asn Asn Ser Lys Asp Thr 
            260                 265                 270         


Leu Leu Val Gln Leu Asn Glu Ser Ile Pro Ile Asn Cys Thr Arg Pro 
        275                 280                 285             


Gly Asn Lys Thr Arg Gly Gln Val Gln Ile Gly Pro Gly Met Thr Phe 
    290                 295                 300                 


Tyr Asn Ile Glu Asn Ile Ile Gly Asp Thr Arg Gln Ala Tyr Cys Glu 
305                 310                 315                 320 


Val Asn Arg Thr Trp Glu Gln Ile Trp Asn Thr Thr Lys Gln Ile Ile 
                325                 330                 335     


Ile Asn Asn Arg Lys Asn Ile Thr Phe Ile Pro Asn Pro Gly Gly Asp 
            340                 345                 350         


Leu Glu Val Thr Asn Leu Met Ile Asn Cys Gly Gly Glu Phe Phe Tyr 
        355                 360                 365             


Cys Asn Thr Ser Gln Leu Phe Thr Asn Gln Asn Gly Asn Thr Thr Gly 
    370                 375                 380                 


Asn Ile Thr Leu Gln Cys Arg Ile Arg Gln Ile Val Asn Leu Trp Thr 
385                 390                 395                 400 


Arg Val Gly Lys Gly Ile Tyr Ala Pro Pro Ile Lys Gly Pro Ile Asn 
                405                 410                 415     


Cys Leu Ser Asn Ile Thr Gly Ile Ile Leu Asp Tyr Thr Lys Ser Gly 
            420                 425                 430         


Thr Glu Lys Tyr Thr Ile Tyr Pro Thr Gly Gly Asp Met Thr Asn Leu 
        435                 440                 445             


Trp Arg Gln Glu Leu Tyr Lys Tyr Lys Val Val Ser Ile Glu Pro Ile 
    450                 455                 460                 


Gly Val Ala Pro Gly Lys Ala Lys Arg His Thr Val Thr Arg Gln Lys 
465                 470                 475                 480 


Arg Ala Ala Phe Gly Leu Gly Ala Leu Phe Leu Gly Phe Leu Gly Ala 
                485                 490                 495     


Ala Gly Ser Thr Met Gly Ala Ala Ser Ile Thr Leu Thr Val Gln Ala 
            500                 505                 510         


Arg Lys Leu Leu Ser Gly Ile Val Gln Gln Gln Asn Asn Leu Leu Arg 
        515                 520                 525             


Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu Ser Val Trp Gly Ile 
    530                 535                 540                 


Lys Gln Leu Gln Ala Arg Val Leu Ala Ile Glu Arg Tyr Leu Arg Asp 
545                 550                 555                 560 


Gln Gln Ile Leu Gly Leu Trp Gly Cys Ser Gly Lys Ser Val Cys Tyr 
                565                 570                 575     


Thr Asn Val Pro Trp Asn Thr Thr Trp Ser Asn Asn Asn Ser Tyr Asp 
            580                 585                 590         


Thr Ile Trp Gly Asn Met Thr Trp Gln Asn Trp Asp Glu Gln Val Arg 
        595                 600                 605             


Asn Tyr Ser Gly Val Ile Phe Gly Leu Leu Glu Gln Ala Gln Glu Gln 
    610                 615                 620                 


Gln Ser Ile Asn Glu Lys Ser Leu Leu Glu Leu Asp Gln Trp Ser Ser 
625                 630                 635                 640 


Leu Trp Asn Trp Phe Asp Ile Thr Lys Trp Leu Trp Tyr Ile Lys Ile 
                645                 650                 655     


Phe Ile Met Val Val Ala Gly Ile Val Gly Ile Arg Ile Ile Ser Ile 
            660                 665                 670         


Ile Met Ser Met Val Ala Arg Val Arg Gln Gly Tyr Ser Pro Leu Ser 
        675                 680                 685             


Leu Gln Thr Leu Ile Pro Thr Thr Arg Gly Pro Asp Arg Pro Glu Arg 
    690                 695                 700                 


Thr Glu Glu Asp Ala Gly Glu Leu Asp Asn Gly Arg Ser Val Arg Leu 
705                 710                 715                 720 


Val Ser Gly Phe Leu Ala Leu Ala Trp Glu Asp Phe Arg Asn Leu Leu 
                725                 730                 735     


Leu Phe Leu Tyr His Arg Leu Thr Asp Cys Leu Ser Ile Leu Arg Arg 
            740                 745                 750         


Thr Leu Glu Leu Leu Arg Gln Asn Ile His Lys Gly Leu Gln Leu Leu 
        755                 760                 765             


Asn Glu Leu Arg Ile Tyr Leu Trp Gly Ile Ile Ala Tyr Trp Gly Arg 
    770                 775                 780                 


Glu Leu Lys Ile Ser Ala Ile Asn Leu Leu Asp Thr Thr Ala Val Ala 
785                 790                 795                 800 


Val Ala Glu Gly Thr Asp Arg Ile Ile Glu Leu Val Gln Arg Ile Gly 
                805                 810                 815     


Arg Gly Ile Leu His Ile Pro Arg Arg Ile Arg Gln Gly Leu Glu Arg 
            820                 825                 830         


Ala Leu Leu 
        835 


<210>  205
<211>  855
<212>  PRT
<213>  Feline immunodeficiency virus

<400>  205

Met Ala Glu Gly Phe Ala Val Asn Arg Gln Trp Ile Gly Pro Glu Glu 
1               5                   10                  15      


Ala Glu Glu Leu Leu Asp Phe Asp Ile Ala Thr Gln Met Asn Glu Glu 
            20                  25                  30          


Gly Pro Leu Asn Pro Gly Ile Asn Leu Phe Arg Val Pro Gly Ile Thr 
        35                  40                  45              


Glu Thr Glu Lys Gln Glu Tyr Cys Asn Ile Leu Gln Pro Lys Leu Gln 
    50                  55                  60                  


Asp Leu Arg Asn Glu Ile Gln Glu Val Lys Leu Glu Glu Gly Asn Ala 
65                  70                  75                  80  


Gly Lys Phe Arg Arg Ala Arg Phe Leu Arg Tyr Ser Asp Glu Thr Ile 
                85                  90                  95      


Leu Ser Leu Ile His Leu Phe Ile Gly Tyr Cys Thr Tyr Leu Cys Lys 
            100                 105                 110         


Arg Asn Lys Leu Gly Thr Leu Val His Asn Ile Asp Ile Glu Ala Pro 
        115                 120                 125             


Gln Glu Glu Cys Tyr Ser Asn Arg Glu Arg Gly Thr Thr Val Asn Ile 
    130                 135                 140                 


Lys Tyr Ser Arg Arg Cys Cys Ile Gly Thr Thr Ala Leu Tyr Leu Leu 
145                 150                 155                 160 


Leu Leu Thr Gly Ile Ile Ile Tyr Thr Gln Thr Thr Gln Ala Gln Val 
                165                 170                 175     


Val Trp Arg Leu Pro Pro Leu Val Val Pro Val Glu Glu Ser Glu Ile 
            180                 185                 190         


Ile Phe Trp Asp Cys Trp Ala Pro Glu Glu Pro Ala Cys Gln Asp Phe 
        195                 200                 205             


Leu Gly Ala Met Ile Tyr Leu Lys Ala Ser Thr Asn Ile Ser Ile Gln 
    210                 215                 220                 


Glu Gly Pro Thr Leu Gly Asn Trp Ala Arg Glu Ile Trp Gly Thr Leu 
225                 230                 235                 240 


Phe Lys Lys Ala Thr Arg Gln Cys Arg Arg Gly Arg Ile Trp Arg Arg 
                245                 250                 255     


Trp Asn Glu Thr Ile Thr Gly Pro Ser Gly Cys Ala Asn Asn Thr Cys 
            260                 265                 270         


Tyr Asn Ile Ser Val Ile Val Pro Asp Tyr Gln Cys Tyr Leu Asp Arg 
        275                 280                 285             


Val Asp Thr Trp Leu Gln Gly Lys Val Asn Ile Ser Leu Cys Leu Thr 
    290                 295                 300                 


Gly Gly Lys Met Leu Tyr Asn Lys Asp Thr Lys Gln Leu Ser Tyr Cys 
305                 310                 315                 320 


Thr Asp Pro Leu Gln Ile Pro Leu Ile Asn Tyr Thr Phe Gly Pro Asn 
                325                 330                 335     


Gln Thr Cys Met Trp Asn Thr Ser Gln Ile Gln Asp Ser Asp Ile Pro 
            340                 345                 350         


Lys Cys Gly Trp Trp Asn Gln Ile Ala Tyr Tyr Asn Ser Cys Arg Trp 
        355                 360                 365             


Glu Gln Thr Asp Val Lys Phe His Cys Gln Arg Thr Gln Ser Gln Pro 
    370                 375                 380                 


Gly Thr Trp Leu Arg Thr Ile Ser Ser Trp Lys Gln Lys Asn Arg Trp 
385                 390                 395                 400 


Glu Trp Arg Pro Asp Phe Glu Ser Glu Lys Val Arg Val Ser Leu Gln 
                405                 410                 415     


Cys Asn Thr Thr Lys Asn Leu Thr Phe Ala Met Arg Ser Ser Gly Asp 
            420                 425                 430         


Tyr Gly Glu Val Thr Gly Ala Trp Ile Glu Phe Gly Cys His Arg Asn 
        435                 440                 445             


Lys Ser Lys Leu His Ser Asp Ala Arg Phe Arg Ile Arg Cys Arg Trp 
    450                 455                 460                 


Asn Val Gly Asp Asn Thr Ser Leu Ile Asp Thr Cys Gly Asn Asp Pro 
465                 470                 475                 480 


Asn Val Ser Gly Ala Asn Pro Val Asp Cys Thr Met Tyr Ala Asn Arg 
                485                 490                 495     


Met Tyr Asn Cys Ser Leu Gln Asn Gly Phe Thr Met Lys Val Asp Asp 
            500                 505                 510         


Leu Ile Met His Phe Asn Met Thr Lys Ala Val Glu Met Tyr Asn Ile 
        515                 520                 525             


Ala Gly Asn Trp Ser Cys Thr Ser Asp Leu Pro Ser Thr Trp Gly Tyr 
    530                 535                 540                 


Met Asn Cys Asn Cys Thr Asn Ser Ser Ser Thr Asp Ser Asn Lys Met 
545                 550                 555                 560 


Ala Cys Pro Lys Arg Gln Gly Ile Leu Arg Asn Trp Tyr Asn Pro Val 
                565                 570                 575     


Ala Gly Leu Arg Gln Ser Leu Glu Lys Tyr Gln Val Val Lys Gln Pro 
            580                 585                 590         


Asp Tyr Leu Val Val Pro Arg Glu Val Met Glu Tyr Lys Pro Arg Arg 
        595                 600                 605             


Lys Arg Ala Ala Ile His Val Met Leu Ala Leu Ala Thr Val Leu Ser 
    610                 615                 620                 


Met Ala Gly Ala Gly Thr Gly Ala Thr Ala Ile Gly Met Val Thr Gln 
625                 630                 635                 640 


Tyr His Gln Val Leu Ala Thr His Gln Glu Thr Ile Glu Lys Ile Thr 
                645                 650                 655     


Glu Ala Leu Lys Val Asn Asn Leu Arg Leu Val Thr Leu Glu His Gln 
            660                 665                 670         


Val Leu Val Ile Gly Leu Lys Val Glu Ala Ile Glu Lys Phe Leu Tyr 
        675                 680                 685             


Thr Ala Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln Phe Phe 
    690                 695                 700                 


Cys Lys Val Pro Pro Glu Leu Trp Gln Arg Tyr Asn Met Thr Ile Asn 
705                 710                 715                 720 


Gln Thr Ile Trp Asn His Gly Asn Ile Thr Leu Gly Glu Trp Tyr Asn 
                725                 730                 735     


Gln Thr Lys Asp Leu Gln Gln Lys Phe Tyr Glu Ile Ile Met Asp Met 
            740                 745                 750         


Glu Gln Asn Asn Val Gln Gly Arg Lys Gly Leu Gln Gln Leu Gln Glu 
        755                 760                 765             


Trp Glu Asp Trp Val Gly Trp Leu Gly Asn Ile Pro Arg Tyr Leu Lys 
    770                 775                 780                 


Gly Leu Leu Gly Gly Ile Leu Gly Ile Gly Leu Gly Val Leu Leu Leu 
785                 790                 795                 800 


Ile Leu Cys Leu Pro Thr Leu Val Asp Cys Ile Arg Asn Cys Ile Ser 
                805                 810                 815     


Lys Val Leu Gly Tyr Thr Val Ile Ala Met Pro Glu Val Glu Glu Glu 
            820                 825                 830         


Glu Ile Gln Pro Pro Met Glu Leu Arg Arg Asn Gly Arg Gln Cys Asp 
        835                 840                 845             


Met Ser Glu Lys Glu Glu Glu 
    850                 855 


<210>  206
<211>  854
<212>  PRT
<213>  Feline immunodeficiency virus

<400>  206

Met Ala Glu Gly Phe Ala Ala Asn Arg Gln Trp Ile Gly Pro Glu Glu 
1               5                   10                  15      


Ala Glu Glu Leu Leu Asp Phe Asp Lys Ala Thr Gln Met Asn Glu Glu 
            20                  25                  30          


Gly Pro Leu Asn Pro Gly Val Asn Pro Phe Arg Val Pro Ala Val Thr 
        35                  40                  45              


Glu Ala Asp Lys Gln Glu Tyr Cys Lys Ile Leu Gln Pro Arg Leu Gln 
    50                  55                  60                  


Glu Ile Arg Asn Glu Ile Gln Glu Val Lys Leu Glu Glu Gly Asn Ala 
65                  70                  75                  80  


Gly Lys Phe Arg Arg Ala Arg Phe Leu Arg Tyr Ser Asp Glu Ser Ile 
                85                  90                  95      


Leu Ser Leu Ile His Leu Phe Ile Gly Tyr Cys Thr Tyr Leu Val Asn 
            100                 105                 110         


Arg Arg Arg Leu Gly Ser Leu Arg His Asp Ile Asn Ile Glu Ala Pro 
        115                 120                 125             


Gln Glu Glu Gln Tyr Ser Ser Arg Glu Gln Gly Thr Thr Glu Asn Ile 
    130                 135                 140                 


Lys Tyr Gly Arg Arg Cys Leu Ile Gly Thr Ala Ser Leu Tyr Leu Leu 
145                 150                 155                 160 


Leu Phe Ile Gly Val Ala Ile Tyr Leu Gly Thr Thr Asn Ala Gln Ile 
                165                 170                 175     


Val Trp Arg Leu Pro Pro Leu Val Val Pro Val Glu Glu Ser Glu Ile 
            180                 185                 190         


Ile Phe Trp Asp Cys Trp Ala Pro Glu Glu Pro Ala Cys Gln Asp Phe 
        195                 200                 205             


Leu Gly Ala Met Ile His Leu Lys Ala Ser Thr Asn Ile Ser Ile Gln 
    210                 215                 220                 


Glu Gly Pro Thr Leu Gly Asn Trp Ala Arg Glu Ile Trp Gly Thr Leu 
225                 230                 235                 240 


Phe Lys Lys Ala Thr Arg His Cys Arg Arg Asn Lys Ile Trp Lys Arg 
                245                 250                 255     


Trp Asn Glu Thr Ile Thr Gly Pro Val Gly Cys Ala Asn Asn Thr Cys 
            260                 265                 270         


Tyr Asn Ile Ser Val Ile Ile Pro Asp Tyr Gln Cys Tyr Leu Asp Arg 
        275                 280                 285             


Val Asp Thr Trp Leu Gln Gly Lys Val Asn Ile Ser Leu Cys Leu Thr 
    290                 295                 300                 


Gly Gly Lys Met Leu Tyr Asn Arg Asp Thr Lys Gln Leu Ser Tyr Cys 
305                 310                 315                 320 


Thr Asp Pro Leu Gln Ile Pro Leu Ile Asn Tyr Thr Phe Gly Pro Asn 
                325                 330                 335     


Gln Thr Cys Met Trp Asn Thr Ser Gln Ile Gln Asp Pro Glu Ile Pro 
            340                 345                 350         


Lys Cys Gly Trp Trp Asn Gln Ile Ala Tyr Tyr Asn Ser Cys Arg Trp 
        355                 360                 365             


Glu Ser Thr Asn Val Lys Phe Tyr Cys Gln Arg Thr Gln Ser Gln Pro 
    370                 375                 380                 


Gly Thr Trp Ile Arg Thr Ile Ser Ser Trp Arg Gln Lys Asn Arg Trp 
385                 390                 395                 400 


Glu Trp Arg Pro Asp Phe Glu Ser Glu Lys Val Lys Ile Ser Leu Gln 
                405                 410                 415     


Cys Asn Ser Thr His Asn Leu Thr Phe Ala Met Arg Ser Ser Gly Asp 
            420                 425                 430         


Tyr Gly Glu Val Met Gly Ala Trp Ile Glu Phe Gly Cys His Arg Asn 
        435                 440                 445             


Lys Ser Arg Phe His Thr Glu Ala Arg Phe Arg Ile Arg Cys Arg Trp 
    450                 455                 460                 


Asn Val Gly Asp Asn Thr Ser Leu Ile Asp Thr Cys Gly Lys Asn Leu 
465                 470                 475                 480 


Asn Val Ser Gly Ala Asn Pro Val Asp Cys Thr Met Tyr Ala Asn Lys 
                485                 490                 495     


Met Tyr Asn Cys Ser Leu Gln Asn Gly Phe Thr Met Lys Val Asp Asp 
            500                 505                 510         


Leu Ile Met His Phe Asn Met Thr Lys Ala Val Glu Met Tyr Asn Ile 
        515                 520                 525             


Ala Gly Asn Trp Ser Cys Lys Ser Asp Leu Pro Gln Asn Trp Gly Tyr 
    530                 535                 540                 


Met Asn Cys Asn Cys Thr Asn Gly Thr Ser Asn Asp Asn Lys Met Ala 
545                 550                 555                 560 


Cys Pro Glu Asp Lys Gly Ile Leu Arg Asn Trp Tyr Asn Pro Val Ala 
                565                 570                 575     


Gly Leu Arg Gln Ala Leu Glu Lys Tyr Gln Val Val Lys Gln Pro Glu 
            580                 585                 590         


Tyr Ile Val Val Pro Thr Glu Val Met Thr Tyr Lys Tyr Lys Gln Lys 
        595                 600                 605             


Arg Ala Ala Ile His Ile Met Leu Ala Leu Ala Thr Val Leu Ser Ile 
    610                 615                 620                 


Ala Gly Ala Gly Thr Gly Ala Thr Ala Ile Gly Met Val Thr Gln Tyr 
625                 630                 635                 640 


Gln Gln Val Leu Ala Thr His Gln Glu Ala Leu Asp Lys Ile Thr Glu 
                645                 650                 655     


Ala Leu Lys Ile Asn Asn Leu Arg Leu Val Thr Leu Glu His Gln Met 
            660                 665                 670         


Leu Val Ile Gly Leu Lys Val Glu Ala Ile Glu Lys Phe Leu Tyr Thr 
        675                 680                 685             


Ala Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln Phe Phe Cys 
    690                 695                 700                 


Glu Ile Pro Lys Glu Leu Trp Leu Arg Tyr Asn Met Thr Leu Asn Gln 
705                 710                 715                 720 


Thr Ile Trp Asn His Gly Asn Ile Thr Leu Gly Glu Trp Tyr Asn Gln 
                725                 730                 735     


Thr Lys Tyr Leu Gln Gln Lys Phe Tyr Glu Ile Ile Met Asp Ile Glu 
            740                 745                 750         


Gln Asn Asn Val Gln Gly Lys Gln Gly Leu Gln Lys Leu Gln Asn Trp 
        755                 760                 765             


Gln Asp Trp Met Gly Trp Ile Gly Lys Ile Pro Gln Tyr Leu Lys Gly 
    770                 775                 780                 


Leu Leu Gly Gly Ile Leu Gly Ile Gly Leu Gly Ile Leu Leu Leu Ile 
785                 790                 795                 800 


Leu Cys Leu Pro Thr Leu Val Asp Cys Ile Arg Asn Cys Ile Ser Lys 
                805                 810                 815     


Val Leu Gly Tyr Thr Val Ile Ala Met Pro Glu Ile Asp Asp Glu Glu 
            820                 825                 830         


Glu Thr Val Gln Met Glu Leu Arg Lys Asn Gly Arg Gln Cys Gly Met 
        835                 840                 845             


Ser Glu Lys Glu Glu Glu 
    850                 


<210>  207
<211>  854
<212>  PRT
<213>  Feline immunodeficiency virus

<400>  207

Met Ala Glu Gly Phe Ala Ala Asn Arg Gln Trp Ile Gly Pro Glu Glu 
1               5                   10                  15      


Ala Glu Glu Leu Leu Asp Phe Asp Ile Ala Ile Gln Met Asn Glu Glu 
            20                  25                  30          


Gly Pro Leu Asn Pro Gly Val Asn Pro Phe Arg Val Pro Gly Ile Thr 
        35                  40                  45              


Glu Ala Glu Lys Gln Glu Tyr Cys Asn Ile Leu Gln Pro Lys Leu Gln 
    50                  55                  60                  


Asp Leu Lys Gly Lys Ile Gln Glu Val Lys Leu Glu Glu Gly Asn Ala 
65                  70                  75                  80  


Gly Lys Phe Arg Arg Ala Arg Phe Leu Arg Tyr Ser Asp Glu Thr Val 
                85                  90                  95      


Leu Ser Leu Ile His Leu Phe Ile Gly Tyr Cys Pro His Leu Cys Arg 
            100                 105                 110         


Arg His Glu Leu Gly Ser Leu Arg His Asp Ile Asp Ile Glu Ala Leu 
        115                 120                 125             


Gln Glu Glu Arg Tyr Asn Asp Arg Glu Lys Gly Ile Thr Asp Asn Ile 
    130                 135                 140                 


Lys Tyr Gly Lys Arg Cys Leu Ile Gly Thr Ala Val Leu Tyr Leu Leu 
145                 150                 155                 160 


Leu Ser Leu Gly Ile Ile Ile His Thr Cys Lys Ala Gln Val Val Trp 
                165                 170                 175     


Arg Leu Pro Pro Leu Val Val Pro Val Glu Glu Ser Glu Ile Ile Phe 
            180                 185                 190         


Trp Asp Cys Trp Ala Pro Glu Glu Pro Ala Cys Gln Asp Phe Leu Gly 
        195                 200                 205             


Ala Met Ile His Leu Lys Ala Ser Thr Asn Ile Ser Ile Gln Glu Gly 
    210                 215                 220                 


Pro Thr Leu Gly Asn Trp Ala Arg Glu Ile Trp Gly Thr Leu Phe Lys 
225                 230                 235                 240 


Lys Ala Thr Arg Gln Cys Arg Arg Gly Arg Ile Trp Arg Arg Trp Asn 
                245                 250                 255     


Glu Thr Ile Thr Gly Pro Leu Gly Cys Ala Asn Asn Thr Cys Tyr Asn 
            260                 265                 270         


Ile Ser Val Ile Val Pro Asp Tyr Gln Cys Tyr Leu Asp Arg Val Asp 
        275                 280                 285             


Thr Trp Leu Gln Gly Lys Val Asn Ile Ser Leu Cys Leu Thr Gly Gly 
    290                 295                 300                 


Lys Met Leu Tyr Asn Lys Glu Thr Lys Gln Leu Ser Tyr Cys Thr Asp 
305                 310                 315                 320 


Pro Leu Gln Ile Pro Leu Ile Asn Tyr Thr Phe Gly Pro Asn Gln Thr 
                325                 330                 335     


Cys Met Trp Asn Thr Ser Gln Ile Gln Asp Pro Glu Ile Pro Lys Cys 
            340                 345                 350         


Gly Trp Trp Asn Gln Asn Ala Tyr Tyr Asn Ser Cys Arg Trp Glu His 
        355                 360                 365             


Thr Asp Val Gln Phe Gln Cys Gln Arg Thr Gln Ser Gln Pro Gly Ser 
    370                 375                 380                 


Trp Ile Arg Ala Ile Ser Ser Trp Lys Gln Arg Asn Arg Trp Glu Trp 
385                 390                 395                 400 


Arg Pro Asp Phe Glu Ser Glu Lys Val Lys Val Ser Leu Gln Cys Asn 
                405                 410                 415     


Ser Thr Lys Asn Leu Thr Phe Ala Met Arg Ser Ser Gly Asp Tyr Gly 
            420                 425                 430         


Glu Val Thr Gly Ala Trp Ile Glu Phe Gly Cys His Arg Thr Lys Ser 
        435                 440                 445             


Lys Tyr His Thr Glu Ala Arg Phe Arg Ile Arg Cys Arg Trp Asn Val 
    450                 455                 460                 


Gly Asp Asn Thr Ser Leu Ile Asp Thr Cys Gly Glu Thr Gln Asn Val 
465                 470                 475                 480 


Ser Arg Ala Asn Pro Val Asp Cys Thr Met Tyr Ala Asn Arg Met Tyr 
                485                 490                 495     


Asn Cys Ser Leu Gln Asn Gly Phe Thr Met Lys Val Asp Asp Leu Ile 
            500                 505                 510         


Met His Phe Asn Lys Thr Lys Ala Val Glu Met Tyr Asn Ile Ala Gly 
        515                 520                 525             


Asn Trp Ser Cys Lys Ser Asp Leu Pro Pro Thr Trp Gly Tyr Met Asn 
    530                 535                 540                 


Cys Asn Cys Thr Asn Ser Thr Asn Ser Gly Thr Gly Ile Arg Met Ala 
545                 550                 555                 560 


Cys Pro Arg Asn Gln Gly Ile Leu Arg Asn Trp Tyr Asn Pro Val Ala 
                565                 570                 575     


Gly Leu Arg Gln Ser Leu Glu Lys Tyr Gln Val Val Lys Gln Pro Asp 
            580                 585                 590         


Tyr Leu Val Val Pro Gly Glu Val Met Glu Tyr Lys Pro Arg Arg Lys 
        595                 600                 605             


Arg Ala Ala Ile His Val Met Leu Ala Leu Ala Thr Val Leu Ser Met 
    610                 615                 620                 


Ala Gly Ala Gly Thr Gly Ala Thr Ala Ile Gly Met Val Thr Gln Tyr 
625                 630                 635                 640 


Gln Gln Val Leu Ala Thr His Gln Glu Ala Ile Glu Lys Val Thr Glu 
                645                 650                 655     


Ala Leu Lys Ile Asn Asn Leu Arg Leu Val Thr Leu Glu His Gln Val 
            660                 665                 670         


Leu Val Ile Gly Leu Lys Val Glu Ala Met Glu Lys Phe Leu Tyr Thr 
        675                 680                 685             


Ala Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln Phe Phe Cys 
    690                 695                 700                 


Lys Val Pro Ser Ala Leu Trp Glu Arg Tyr Asn Met Thr Ile Asn Gln 
705                 710                 715                 720 


Thr Ile Trp Asn His Gly Asn Ile Thr Leu Gly Glu Trp Tyr Asn Gln 
                725                 730                 735     


Thr Lys Asp Leu Gln Gln Arg Phe Tyr Glu Ile Ile Met Asp Ile Glu 
            740                 745                 750         


Gln Asn Asn Val Gln Gly Lys Lys Gly Leu Gln Gln Leu Gln Glu Trp 
        755                 760                 765             


Glu Asp Trp Val Gly Trp Ile Gly Asn Ile Pro Gln Tyr Leu Lys Gly 
    770                 775                 780                 


Leu Leu Gly Gly Ile Leu Gly Ile Gly Leu Gly Met Leu Leu Leu Ile 
785                 790                 795                 800 


Leu Cys Leu Pro Thr Leu Val Asp Cys Ile Arg Asn Cys Ile His Lys 
                805                 810                 815     


Ile Leu Gly Tyr Thr Val Ile Ala Met Pro Glu Val Glu Glu Glu Glu 
            820                 825                 830         


Ile Gln Pro Gln Met Glu Leu Arg Arg Asn Gly Arg Gln Cys Gly Met 
        835                 840                 845             


Ser Glu Lys Glu Glu Glu 
    850                 


<210>  208
<211>  856
<212>  PRT
<213>  Feline immunodeficiency virus

<400>  208

Met Ala Glu Gly Phe Ala Ala Asn Arg Gln Trp Ile Gly Pro Glu Glu 
1               5                   10                  15      


Ala Glu Glu Leu Leu Asp Phe Asp Ile Ala Thr Gln Met Ser Glu Glu 
            20                  25                  30          


Gly Pro Leu Asn Pro Gly Val Asn Pro Phe Arg Val Pro Gly Ile Thr 
        35                  40                  45              


Glu Lys Glu Lys Gln Asn Tyr Cys Asn Ile Leu Gln Pro Lys Leu Gln 
    50                  55                  60                  


Asp Leu Arg Asn Glu Ile Gln Glu Val Lys Leu Glu Glu Gly Asn Ala 
65                  70                  75                  80  


Gly Lys Phe Arg Arg Ala Arg Phe Leu Arg Tyr Ser Asp Glu Arg Val 
                85                  90                  95      


Leu Ser Leu Val His Ala Phe Ile Gly Tyr Cys Ile Tyr Leu Gly Asn 
            100                 105                 110         


Arg Asn Lys Leu Gly Ser Leu Arg His Asp Ile Asp Ile Glu Ala Pro 
        115                 120                 125             


Gln Glu Glu Cys Tyr Asn Asn Arg Glu Lys Gly Thr Thr Asp Asn Ile 
    130                 135                 140                 


Lys Tyr Gly Arg Arg Cys Cys Leu Gly Thr Val Thr Leu Tyr Leu Ile 
145                 150                 155                 160 


Leu Phe Thr Gly Val Ile Val Tyr Ser Gln Thr Ala Gly Ala Gln Val 
                165                 170                 175     


Val Trp Arg Leu Pro Pro Leu Val Val Pro Val Glu Glu Ser Glu Ile 
            180                 185                 190         


Ile Phe Trp Asp Cys Trp Ala Pro Glu Glu Pro Ala Cys Gln Asp Phe 
        195                 200                 205             


Leu Gly Ala Met Ile His Leu Lys Ala Lys Thr Asn Ile Ser Ile Arg 
    210                 215                 220                 


Glu Gly Pro Thr Leu Gly Asn Trp Ala Arg Glu Ile Trp Ala Thr Leu 
225                 230                 235                 240 


Phe Lys Lys Ala Thr Arg Gln Cys Arg Arg Gly Arg Ile Trp Lys Arg 
                245                 250                 255     


Trp Asn Glu Thr Ile Thr Gly Pro Ser Gly Cys Ala Asn Asn Thr Cys 
            260                 265                 270         


Tyr Asn Val Ser Val Ile Val Pro Asp Tyr Gln Cys Tyr Leu Asp Arg 
        275                 280                 285             


Val Asp Thr Trp Leu Gln Gly Lys Ile Asn Ile Ser Leu Cys Leu Thr 
    290                 295                 300                 


Gly Gly Lys Met Leu Tyr Asn Lys Val Thr Lys Gln Leu Ser Tyr Cys 
305                 310                 315                 320 


Thr Asp Pro Leu Gln Ile Pro Leu Ile Asn Tyr Thr Phe Gly Pro Asn 
                325                 330                 335     


Gln Thr Cys Met Trp Asn Thr Ser Gln Ile Gln Asp Pro Glu Ile Pro 
            340                 345                 350         


Lys Cys Gly Trp Trp Asn Gln Met Ala Tyr Tyr Asn Ser Cys Lys Trp 
        355                 360                 365             


Glu Glu Ala Lys Val Lys Phe His Cys Gln Arg Thr Gln Ser Gln Pro 
    370                 375                 380                 


Gly Ser Trp Phe Arg Ala Ile Ser Ser Trp Lys Gln Arg Asn Arg Trp 
385                 390                 395                 400 


Glu Trp Arg Pro Asp Phe Lys Ser Lys Lys Val Lys Ile Ser Leu Pro 
                405                 410                 415     


Cys Asn Ser Thr Lys Asn Leu Thr Phe Ala Met Arg Ser Ser Gly Asp 
            420                 425                 430         


Tyr Gly Glu Val Thr Gly Ala Trp Ile Glu Phe Gly Cys His Arg Asn 
        435                 440                 445             


Lys Ser Asn Leu His Thr Glu Ala Arg Phe Arg Ile Arg Cys Arg Trp 
    450                 455                 460                 


Asn Val Gly Ser Asp Thr Ser Leu Ile Asp Thr Cys Gly Asn Thr Pro 
465                 470                 475                 480 


Asn Val Ser Gly Ala Asn Pro Val Asp Cys Thr Met Tyr Ser Asn Lys 
                485                 490                 495     


Met Tyr Asn Cys Ser Leu Gln Asn Gly Phe Thr Met Lys Val Asp Asp 
            500                 505                 510         


Leu Ile Val His Phe Asn Met Thr Lys Ala Val Glu Met Tyr Asn Ile 
        515                 520                 525             


Ala Gly Asn Trp Ser Cys Thr Ser Asp Leu Pro Ser Ser Trp Gly Tyr 
    530                 535                 540                 


Met Asn Cys Asn Cys Thr Asn Ser Ser Ser Ser Tyr Ser Gly Thr Lys 
545                 550                 555                 560 


Met Ala Cys Pro Ser Asn Arg Gly Ile Leu Arg Asn Trp Tyr Asn Pro 
                565                 570                 575     


Val Ala Gly Leu Arg Gln Ser Leu Glu Gln Tyr Gln Val Val Lys Gln 
            580                 585                 590         


Pro Asp Tyr Leu Leu Val Pro Glu Glu Val Met Glu Tyr Lys Pro Arg 
        595                 600                 605             


Arg Lys Arg Ala Ala Ile His Val Met Leu Ala Leu Ala Thr Val Leu 
    610                 615                 620                 


Ser Ile Ala Gly Ala Gly Thr Gly Ala Thr Ala Ile Gly Met Val Thr 
625                 630                 635                 640 


Gln Tyr His Gln Val Leu Ala Thr His Gln Glu Ala Ile Glu Lys Val 
                645                 650                 655     


Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu Val Thr Leu Glu His 
            660                 665                 670         


Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala Met Glu Lys Phe Leu 
        675                 680                 685             


Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln Phe 
    690                 695                 700                 


Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg Tyr Asn Met Thr Ile 
705                 710                 715                 720 


Asn Gln Thr Ile Trp Asn His Gly Asn Ile Thr Leu Gly Glu Trp Tyr 
                725                 730                 735     


Asn Gln Thr Lys Asp Leu Gln Gln Lys Phe Tyr Glu Ile Ile Met Asp 
            740                 745                 750         


Ile Glu Gln Asn Asn Val Gln Gly Lys Thr Gly Ile Gln Gln Leu Gln 
        755                 760                 765             


Lys Trp Glu Asp Trp Val Arg Trp Ile Gly Asn Ile Pro Gln Tyr Leu 
    770                 775                 780                 


Lys Gly Leu Leu Gly Gly Ile Leu Gly Ile Gly Leu Gly Val Leu Leu 
785                 790                 795                 800 


Leu Ile Leu Cys Leu Pro Thr Leu Val Asp Cys Ile Arg Asn Cys Ile 
                805                 810                 815     


His Lys Ile Leu Gly Tyr Thr Val Ile Ala Met Pro Glu Val Glu Gly 
            820                 825                 830         


Glu Glu Ile Gln Pro Gln Met Glu Leu Arg Arg Asn Gly Arg Gln Cys 
        835                 840                 845             


Gly Met Ser Glu Lys Glu Glu Glu 
    850                 855     


<210>  209
<211>  855
<212>  PRT
<213>  Feline immunodeficiency virus

<400>  209

Met Ala Glu Gly Phe Ala Ala Asn Arg Gln Trp Ile Gly Pro Glu Glu 
1               5                   10                  15      


Ala Glu Glu Leu Leu Asp Phe Asp Ile Ala Thr Gln Met Asn Glu Glu 
            20                  25                  30          


Gly Pro Leu Asn Pro Gly Ile Asn Pro Phe Arg Val Pro Gly Ile Thr 
        35                  40                  45              


Glu Thr Glu Lys Gln Asp Tyr Cys Asn Met Leu Gln Pro Lys Leu Gln 
    50                  55                  60                  


Ala Leu Arg Asn Glu Ile Gln Glu Val Lys Leu Glu Glu Gly Asn Ala 
65                  70                  75                  80  


Gly Lys Phe Arg Arg Ala Arg Phe Leu Arg Tyr Ser Asp Glu Thr Ile 
                85                  90                  95      


Leu Ser Leu Ile His Leu Phe Ile Gly Tyr Cys Thr Tyr Leu Leu Asn 
            100                 105                 110         


Arg Lys Glu Leu Gly Ser Leu Arg His Asp Ile Asp Ile Glu Ala Pro 
        115                 120                 125             


Gln Glu Glu Cys Tyr Ser Ser Arg Glu Gln Ser Ile Thr Asp Asn Ile 
    130                 135                 140                 


Lys Tyr Gly Lys Arg Cys Phe Ile Gly Thr Ala Gly Leu Tyr Leu Leu 
145                 150                 155                 160 


Leu Phe Ile Gly Val Gly Ile Tyr Leu Gly Thr Ala Lys Ala Gln Val 
                165                 170                 175     


Val Trp Arg Leu Pro Pro Leu Val Val Pro Val Glu Glu Ser Glu Ile 
            180                 185                 190         


Ile Phe Trp Asp Cys Trp Ala Pro Glu Glu Pro Ala Cys Gln Asp Phe 
        195                 200                 205             


Leu Gly Ala Met Ile His Leu Lys Ala Ser Thr Asn Ile Ser Ile Gln 
    210                 215                 220                 


Glu Gly Pro Thr Leu Gly Asn Trp Ala Lys Glu Ile Trp Gly Thr Leu 
225                 230                 235                 240 


Phe Lys Lys Ala Thr Arg Gln Cys Arg Arg Gly Arg Ile Trp Lys Arg 
                245                 250                 255     


Trp Asn Glu Thr Ile Thr Gly Pro Leu Gly Cys Ala Asn Asn Thr Cys 
            260                 265                 270         


Tyr Asn Ile Ser Val Ile Val Pro Asp Tyr Gln Cys Tyr Leu Asp Arg 
        275                 280                 285             


Val Asp Thr Trp Leu Gln Gly Lys Val Asn Val Ser Leu Cys Leu Thr 
    290                 295                 300                 


Gly Gly Lys Ile Leu Tyr Asn Lys Tyr Thr Lys Gln Leu Ser Tyr Cys 
305                 310                 315                 320 


Thr Asp Pro Leu Gln Ile Pro Leu Ile Ser Tyr Thr Phe Gly Pro Asn 
                325                 330                 335     


Gln Thr Cys Met Trp Asp Thr Ser Gln Ile Gln Asp Pro Glu Ile Pro 
            340                 345                 350         


Lys Cys Gly Trp Trp Asn Gln Ile Ala Tyr Tyr Asn Ser Cys Arg Trp 
        355                 360                 365             


Glu Ser Thr Asp Val Lys Phe His Cys Gln Arg Thr Gln Ser Gln Pro 
    370                 375                 380                 


Gly Leu Trp Leu Arg Ala Ile Ser Ser Trp Lys Gln Arg Asn Arg Trp 
385                 390                 395                 400 


Glu Trp Arg Pro Asp Phe Glu Ser Glu Lys Ala Lys Val Ser Leu Gln 
                405                 410                 415     


Cys Asn Ser Thr Lys Asn Leu Thr Phe Ala Met Arg Ser Ser Gly Asp 
            420                 425                 430         


Tyr Gly Glu Val Thr Gly Ala Trp Ile Glu Phe Gly Cys His Arg Asn 
        435                 440                 445             


Lys Ser Lys Leu His Thr Glu Ala Arg Phe Arg Ile Arg Cys Arg Trp 
    450                 455                 460                 


Asn Val Gly Asp Asn Thr Ser Leu Ile Asp Thr Cys Gly Glu Thr Gln 
465                 470                 475                 480 


Asn Val Ser Gly Ala Asn Pro Val Asp Cys Thr Met Tyr Ala Asn Arg 
                485                 490                 495     


Met Tyr Asn Cys Ser Leu Gln Asn Gly Phe Thr Met Lys Val Asp Asp 
            500                 505                 510         


Leu Ile Met His Phe Asn Met Thr Lys Ala Val Glu Met Tyr Asp Ile 
        515                 520                 525             


Ala Gly Asn Trp Ser Cys Thr Ser Asp Leu Pro Pro Thr Trp Gly Tyr 
    530                 535                 540                 


Met Asn Cys Asn Cys Thr Asn Ser Ser Ser Thr Asn Ser Val Lys Met 
545                 550                 555                 560 


Ala Cys Pro Lys Asn Gln Gly Ile Leu Arg Asn Trp Tyr Asn Pro Val 
                565                 570                 575     


Ala Gly Leu Arg Gln Ser Leu Glu Lys Tyr Gln Val Val Lys Gln Pro 
            580                 585                 590         


Asp Tyr Leu Val Val Pro Gly Glu Val Met Glu Tyr Lys Pro Arg Arg 
        595                 600                 605             


Lys Arg Ala Ala Ile His Val Met Leu Ala Leu Ala Thr Val Leu Ser 
    610                 615                 620                 


Met Ala Gly Ala Gly Thr Gly Ala Thr Ala Ile Gly Met Val Thr Gln 
625                 630                 635                 640 


Tyr His Gln Val Leu Ala Thr His Gln Glu Thr Ile Glu Lys Val Thr 
                645                 650                 655     


Glu Ala Leu Lys Ile Asn Asn Leu Arg Leu Val Thr Leu Glu His Gln 
            660                 665                 670         


Val Leu Val Ile Gly Leu Lys Val Glu Ala Met Glu Lys Phe Leu Tyr 
        675                 680                 685             


Thr Ala Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln Phe Phe 
    690                 695                 700                 


Cys Lys Val Pro Pro Glu Leu Trp Lys Arg Tyr Asn Met Thr Ile Asn 
705                 710                 715                 720 


Gln Thr Ile Trp Asn His Gly Asn Ile Thr Leu Gly Glu Trp Tyr Asn 
                725                 730                 735     


Gln Thr Lys Glu Leu Gln Gln Lys Phe Tyr Glu Ile Ile Met Asn Ile 
            740                 745                 750         


Glu Gln Asn Asn Val Gln Val Lys Lys Gly Leu Gln Gln Leu Gln Glu 
        755                 760                 765             


Trp Glu Asp Trp Val Gly Trp Ile Gly Asn Ile Pro Gln Tyr Leu Lys 
    770                 775                 780                 


Gly Leu Leu Gly Gly Ile Leu Gly Ile Gly Ile Gly Val Leu Leu Leu 
785                 790                 795                 800 


Ile Leu Cys Leu Pro Thr Leu Val Asp Cys Ile Arg Asn Cys Ile Ser 
                805                 810                 815     


Lys Val Leu Gly Tyr Thr Val Ile Ala Met Pro Glu Ile Gly Asp Glu 
            820                 825                 830         


Glu Glu Thr Val Gln Met Glu Leu Arg Lys Asn Gly Arg Gln Cys Gly 
        835                 840                 845             


Met Ser Glu Lys Glu Glu Glu 
    850                 855 


<210>  210
<211>  856
<212>  PRT
<213>  Feline immunodeficiency virus

<400>  210

Met Ala Glu Gly Phe Val Ala Asn Gly Gln Trp Ile Gly Pro Glu Glu 
1               5                   10                  15      


Ala Glu Glu Leu Val Asp Phe Glu Ile Ala Thr Gln Met Asn Glu Glu 
            20                  25                  30          


Gly Pro Leu Asn Pro Gly Ile Asn Pro Phe Arg Val Pro Gly Ile Thr 
        35                  40                  45              


Lys Gln Glu Lys Gln Glu Tyr Cys Ser Thr Met Gln Pro Lys Leu Gln 
    50                  55                  60                  


Ala Leu Arg Asn Glu Ile Gln Glu Val Lys Leu Glu Glu Gly Asn Ala 
65                  70                  75                  80  


Gly Lys Phe Arg Arg Ala Arg Phe Leu Arg Tyr Ser Asp Glu Thr Ile 
                85                  90                  95      


Leu Ser Leu Ile Tyr Leu Phe Ile Gly Tyr Phe Arg Tyr Leu Val Asp 
            100                 105                 110         


Arg Lys Arg Phe Gly Ser Leu Arg His Asp Ile Asp Ile Glu Ala Pro 
        115                 120                 125             


Gln Glu Glu Cys Tyr Asn Asn Lys Glu Lys Gly Met Thr Glu Asn Ile 
    130                 135                 140                 


Lys Tyr Gly Lys Arg Cys Leu Val Gly Thr Ala Ala Leu Tyr Leu Ile 
145                 150                 155                 160 


Leu Ala Ile Gly Ile Ile Ile Ile Ile Arg Thr Thr Asp Ala Gln Val 
                165                 170                 175     


Val Trp Arg Leu Pro Pro Leu Val Val Pro Val Glu Glu Ser Glu Ile 
            180                 185                 190         


Ile Phe Trp Asp Cys Trp Ala Pro Glu Glu Pro Ala Cys Gln Asp Phe 
        195                 200                 205             


Leu Gly Ala Met Ile His Leu Lys Ala Ser Thr Asn Ile Ser Asn Thr 
    210                 215                 220                 


Glu Gly Pro Thr Leu Gly Asn Trp Ala Arg Glu Ile Trp Ala Thr Leu 
225                 230                 235                 240 


Phe Lys Lys Ala Thr Arg Gln Cys Arg Arg Gly Arg Ile Trp Lys Arg 
                245                 250                 255     


Trp Asn Glu Thr Ile Thr Gly Pro Ile Gly Cys Ala Asn Asn Thr Cys 
            260                 265                 270         


Tyr Asn Ile Ser Val Ile Val Pro Asp Tyr Gln Cys Tyr Ile Asp Arg 
        275                 280                 285             


Val Asp Thr Trp Leu Gln Gly Lys Val Asn Ile Ser Leu Cys Leu Thr 
    290                 295                 300                 


Gly Gly Lys Met Leu Tyr Asn Lys Glu Thr Lys Gln Leu Ser Tyr Cys 
305                 310                 315                 320 


Thr Asp Pro Leu Gln Ile Pro Leu Ile Asn Tyr Thr Phe Gly Pro Asn 
                325                 330                 335     


Gln Thr Cys Met Trp Asn Ile Ser Gln Ile Gln Asp Pro Glu Ile Pro 
            340                 345                 350         


Lys Cys Gly Trp Trp Asn Gln Gln Ala Tyr Tyr Asn Asn Cys Lys Trp 
        355                 360                 365             


Glu Arg Thr Asp Val Lys Phe Gln Cys Gln Arg Thr Gln Ser Gln Pro 
    370                 375                 380                 


Gly Ser Trp Ile Arg Ala Ile Ser Ser Trp Lys Gln Gly Asn Arg Trp 
385                 390                 395                 400 


Glu Trp Arg Pro Asp Phe Glu Ser Glu Arg Val Lys Val Ser Leu Gln 
                405                 410                 415     


Cys Asn Ser Thr Arg Asn Leu Thr Phe Ala Met Arg Ser Ser Gly Asp 
            420                 425                 430         


Tyr Gly Glu Ile Thr Gly Ala Trp Ile Glu Phe Gly Cys His Arg Asn 
        435                 440                 445             


Lys Ser Ile Arg His Asn Ala Ala Arg Phe Arg Ile Arg Cys Arg Trp 
    450                 455                 460                 


Asn Glu Gly Asp Asn Asn Ser Leu Ile Asp Thr Cys Gly Glu Thr Gln 
465                 470                 475                 480 


Asn Val Ser Gly Ala Asn Pro Val Asp Cys Thr Met Tyr Ala Asn Lys 
                485                 490                 495     


Met Tyr Asn Cys Ser Leu Gln Asp Gly Phe Thr Met Lys Val Asp Asp 
            500                 505                 510         


Leu Ile Met His Phe Asn Met Thr Lys Ala Val Glu Met Tyr Asn Ile 
        515                 520                 525             


Ala Gly Asn Trp Ser Cys Met Ser Asp Leu Pro Thr Glu Trp Gly Tyr 
    530                 535                 540                 


Met Asn Cys Asn Cys Thr Asn Asp Thr Ser Asn Asn Asn Thr Arg Lys 
545                 550                 555                 560 


Met Lys Cys Pro Lys Glu Asn Gly Ile Leu Arg Asn Trp Tyr Asn Pro 
                565                 570                 575     


Val Ala Gly Leu Arg Gln Ser Leu Glu Lys Tyr Gln Val Val Lys Gln 
            580                 585                 590         


Pro Asp Tyr Leu Leu Val Pro Glu Glu Val Met Glu Tyr Lys Pro Arg 
        595                 600                 605             


Arg Lys Arg Ala Ala Ile His Val Met Leu Ala Leu Ala Thr Val Leu 
    610                 615                 620                 


Ser Met Ala Gly Ala Gly Thr Gly Ala Thr Ala Ile Gly Met Val Thr 
625                 630                 635                 640 


Gln Tyr His Gln Val Leu Ala Thr Gln Gln Glu Ala Ile Glu Lys Val 
                645                 650                 655     


Thr Glu Ala Leu Lys Ile Thr Asn Leu Arg Leu Val Thr Leu Glu His 
            660                 665                 670         


Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala Met Glu Lys Phe Leu 
        675                 680                 685             


Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln Phe 
    690                 695                 700                 


Phe Cys Lys Val Pro Pro Glu Leu Trp Arg Arg Tyr Asn Met Thr Ile 
705                 710                 715                 720 


Asn Gln Thr Ile Trp Asn His Gly Asn Ile Thr Leu Gly Glu Trp Tyr 
                725                 730                 735     


Asn Gln Thr Lys Asp Leu Gln Lys Lys Phe Tyr Gly Ile Ile Met Asp 
            740                 745                 750         


Ile Glu Gln Asn Asn Val Gln Gly Lys Lys Gly Leu Gln Gln Leu Gln 
        755                 760                 765             


Lys Trp Glu Asp Trp Val Gly Trp Ile Gly Asn Ile Pro Gln Tyr Leu 
    770                 775                 780                 


Lys Gly Leu Leu Gly Ser Ile Val Gly Ile Gly Leu Gly Ile Leu Leu 
785                 790                 795                 800 


Leu Ile Leu Cys Leu Pro Thr Leu Val Asp Cys Ile Arg Asn Cys Ile 
                805                 810                 815     


His Lys Ile Leu Gly Tyr Thr Val Ile Ala Met Pro Glu Val Asp Gly 
            820                 825                 830         


Glu Glu Ile Gln Pro Gln Met Glu Leu Arg Arg Asn Gly Arg Gln Cys 
        835                 840                 845             


Gly Met Ser Glu Lys Glu Glu Glu 
    850                 855     


<210>  211
<211>  575
<212>  PRT
<213>  Mayoro Virus

<400>  211

Glu Gly Arg Ala His Gly Trp Pro His Glu Ile Ile Glu Tyr Tyr Tyr 
1               5                   10                  15      


Gly Leu His Pro Thr Thr Thr Ile Val Val Val Val Ala Val Ser Val 
            20                  25                  30          


Val Val Leu Leu Ser Val Ala Ala Ser Val Tyr Met Cys Val Val Ala 
        35                  40                  45              


Arg Asn Lys Cys Leu Thr Pro Tyr Ala Leu Thr Pro Gly Ala Val Val 
    50                  55                  60                  


Pro Val Thr Ile Gly Val Leu Cys Cys Ala Pro Lys Ala His Ala Ala 
65                  70                  75                  80  


Ser Phe Ala Glu Gly Met Ala Tyr Leu Trp Asp Asn Asn Gln Ser Met 
                85                  90                  95      


Phe Trp Met Glu Leu Thr Gly Pro Leu Ala Leu Leu Ile Leu Thr Thr 
            100                 105                 110         


Cys Cys Ala Arg Ser Leu Leu Ser Cys Cys Lys Gly Ser Phe Leu Val 
        115                 120                 125             


Ala Val Ser Val Gly Ser Ala Val Ala Ser Ala Tyr Glu His Thr Ala 
    130                 135                 140                 


Val Ile Pro Asn Gln Val Gly Phe Pro Tyr Lys Ala His Val Ala Arg 
145                 150                 155                 160 


Glu Gly Tyr Ser Pro Leu Thr Leu Gln Met Gln Val Val Glu Thr Ser 
                165                 170                 175     


Leu Glu Pro Thr Leu Asn Leu Glu Tyr Ile Thr Cys Asp Tyr Lys Thr 
            180                 185                 190         


Lys Val Pro Ser Pro Tyr Val Lys Cys Cys Gly Thr Ala Glu Cys Arg 
        195                 200                 205             


Thr Gln Asp Lys Pro Glu Tyr Lys Cys Ala Val Phe Thr Gly Val Tyr 
    210                 215                 220                 


Pro Phe Met Trp Gly Gly Ala Tyr Cys Phe Cys Asp Ser Glu Asn Thr 
225                 230                 235                 240 


Gln Met Ser Glu Ala Tyr Val Glu Arg Ala Asp Val Cys Lys His Asp 
                245                 250                 255     


Tyr Ala Ala Ala Tyr Arg Ala His Thr Ala Ser Leu Arg Ala Lys Ile 
            260                 265                 270         


Lys Val Thr Tyr Gly Thr Val Asn Gln Thr Val Glu Ala Tyr Val Asn 
        275                 280                 285             


Gly Asp His Ala Val Thr Leu Ala Gly Thr Lys Phe Ile Phe Gly Pro 
    290                 295                 300                 


Val Ser Thr Ala Trp Thr Pro Phe Asp Thr Lys Ile Val Val Tyr Lys 
305                 310                 315                 320 


Gly Glu Val Tyr Asn Gln Asp Phe Pro Pro Tyr Gly Ala Gly Gln Pro 
                325                 330                 335     


Gly Arg Phe Gly Asp Ile Gln Ser Arg Thr Leu Asp Ser Lys Asp Leu 
            340                 345                 350         


Tyr Ala Asn Thr Gly Leu Lys Leu Ala Arg Pro Ala Ala Gly Asn Ile 
        355                 360                 365             


His Val Pro Tyr Thr Gln Thr Pro Ser Gly Phe Lys Thr Trp Gln Lys 
    370                 375                 380                 


Asp Arg Asp Ser Pro Leu Asn Ala Lys Ala Pro Phe Gly Cys Thr Ile 
385                 390                 395                 400 


Gln Thr Asn Pro Val Arg Ala Met Asn Cys Ala Val Gly Asn Ile Pro 
                405                 410                 415     


Val Ser Met Asp Ile Ala Asp Ser Ala Phe Thr Arg Leu Thr Asp Ala 
            420                 425                 430         


Pro Ile Ile Ser Glu Leu Leu Cys Thr Val Ser Thr Cys Thr His Ser 
        435                 440                 445             


Ser Asp Phe Gly Gly Val Ala Val Leu Ser Tyr Lys Val Glu Lys Ala 
    450                 455                 460                 


Gly Arg Cys Asp Val His Ser His Ser Asn Val Ala Val Leu Gln Glu 
465                 470                 475                 480 


Val Ser Ile Glu Ala Glu Gly Arg Ser Val Ile His Phe Ser Thr Ala 
                485                 490                 495     


Ser Ala Ala Pro Ser Phe Ile Val Ser Val Cys Ser Ser Arg Ala Thr 
            500                 505                 510         


Cys Thr Ala Lys Cys Glu Pro Pro Lys Asp His Val Val Thr Tyr Pro 
        515                 520                 525             


Ala Asn His Asn Gly Ile Thr Leu Pro Asp Leu Ser Ser Thr Ala Met 
    530                 535                 540                 


Thr Trp Ala Gln His Leu Ala Gly Gly Val Gly Leu Leu Ile Ala Leu 
545                 550                 555                 560 


Ala Val Leu Ile Leu Val Ile Val Thr Cys Ile Thr Leu Arg Arg 
                565                 570                 575 


<210>  212
<211>  1239
<212>  PRT
<213>  Barmah Forest Virus

<400>  212

Met Asp Phe Ile Pro Thr Gln Thr Phe Tyr Gly Arg Arg Trp Arg Pro 
1               5                   10                  15      


Ala Pro Val Gln Arg Tyr Ile Pro Gln Pro Gln Pro Pro Ala Pro Pro 
            20                  25                  30          


Arg Arg Arg Arg Gly Pro Ser Gln Leu Gln Gln Leu Val Ala Ala Leu 
        35                  40                  45              


Gly Ala Leu Ala Leu Gln Pro Lys Gln Lys Gln Lys Arg Ala Gln Lys 
    50                  55                  60                  


Lys Pro Lys Lys Thr Pro Pro Pro Lys Pro Lys Lys Thr Gln Lys Pro 
65                  70                  75                  80  


Lys Lys Pro Thr Gln Lys Lys Lys Ser Lys Pro Gly Lys Arg Met Arg 
                85                  90                  95      


Asn Cys Met Lys Ile Glu Asn Asp Cys Ile Phe Pro Val Met Leu Asp 
            100                 105                 110         


Gly Lys Val Asn Gly Tyr Ala Cys Leu Val Gly Asp Lys Val Met Lys 
        115                 120                 125             


Pro Ala His Val Lys Gly Thr Ile Asp Asn Pro Glu Leu Ala Lys Leu 
    130                 135                 140                 


Thr Phe Lys Lys Ser Ser Lys Tyr Asp Leu Glu Cys Ala Gln Val Pro 
145                 150                 155                 160 


Val Cys Met Lys Ser Asp Ala Ser Lys Phe Thr His Glu Lys Pro Glu 
                165                 170                 175     


Gly His Tyr Asn Trp His His Gly Ala Val Gln Phe Ser Asn Gly Arg 
            180                 185                 190         


Phe Thr Ile Pro Thr Gly Ser Gly Lys Pro Gly Asp Ser Gly Arg Pro 
        195                 200                 205             


Ile Phe Asp Asn Thr Gly Lys Val Val Ala Ile Val Leu Gly Gly Ala 
    210                 215                 220                 


Asn Glu Gly Ala Arg Thr Ala Leu Ser Val Val Thr Trp Asn Lys Asp 
225                 230                 235                 240 


Met Val Thr Arg Ile Thr Pro Glu Glu Ser Val Glu Trp Ser Ala Ala 
                245                 250                 255     


Ala Leu Asn Ile Thr Ala Leu Cys Val Leu Gln Asn Leu Ser Phe Pro 
            260                 265                 270         


Cys Asp Ala Pro Pro Cys Ala Pro Cys Cys Tyr Glu Lys Asp Pro Ala 
        275                 280                 285             


Gly Thr Leu Arg Leu Leu Ser Asp His Tyr Tyr His Pro Lys Tyr Tyr 
    290                 295                 300                 


Glu Leu Leu Asp Ser Thr Met His Cys Pro Gln Gly Arg Arg Pro Lys 
305                 310                 315                 320 


Arg Ser Val Ala His Phe Glu Ala Tyr Lys Ala Thr Arg Pro Tyr Ile 
                325                 330                 335     


Gly Trp Cys Ala Asp Cys Gly Leu Ala Gly Ser Cys Pro Ser Pro Val 
            340                 345                 350         


Ser Ile Glu His Val Trp Ser Asp Ala Asp Asp Gly Val Leu Lys Ile 
        355                 360                 365             


Gln Val Ser Met Gln Ile Gly Ile Ala Lys Ser Asn Thr Ile Asn His 
    370                 375                 380                 


Ala Lys Ile Arg Tyr Met Gly Ala Asn Gly Val Gln Glu Ala Glu Arg 
385                 390                 395                 400 


Ser Thr Leu Ser Val Ser Thr Thr Ala Pro Cys Asp Ile Leu Ala Thr 
                405                 410                 415     


Met Gly His Phe Ile Leu Ala Arg Cys Arg Pro Gly Ser Gln Val Glu 
            420                 425                 430         


Val Ser Leu Ser Thr Asp Pro Lys Leu Leu Cys Arg Thr Pro Phe Ser 
        435                 440                 445             


His Lys Pro Arg Phe Ile Gly Asn Glu Lys Ser Pro Ala Pro Thr Gly 
    450                 455                 460                 


His Lys Thr Arg Ile Pro Cys Lys Thr Tyr Ser His Gln Thr Asp Leu 
465                 470                 475                 480 


Thr Arg Glu Glu Ile Thr Met His Val Pro Pro Asp Val Pro Ile Gln 
                485                 490                 495     


Gly Leu Val Ser Asn Thr Gly Lys Ser Tyr Ser Leu Asp Pro Lys Thr 
            500                 505                 510         


Lys Thr Ile Lys Tyr Lys Cys Thr Cys Gly Glu Thr Val Lys Glu Gly 
        515                 520                 525             


Thr Ala Thr Asn Lys Ile Thr Leu Phe Asn Cys Asp Thr Ala Pro Lys 
    530                 535                 540                 


Cys Ile Thr Tyr Ala Val Asp Asn Thr Val Trp Gln Tyr Asn Ser Gln 
545                 550                 555                 560 


Tyr Val Pro Arg Ser Glu Val Thr Glu Val Lys Gly Lys Ile His Val 
                565                 570                 575     


Pro Phe Pro Leu Thr Asp Ser Thr Cys Ala Val Ser Val Ala Pro Glu 
            580                 585                 590         


Pro Gln Val Thr Tyr Arg Leu Gly Glu Val Glu Phe His Phe His Pro 
        595                 600                 605             


Met Tyr Pro Thr Leu Phe Ser Ile Arg Ser Leu Gly Lys Asp Pro Ser 
    610                 615                 620                 


His Ser Gln Glu Trp Ile Asp Thr Pro Met Ser Lys Thr Ile Gln Val 
625                 630                 635                 640 


Gly Ala Glu Gly Val Glu Tyr Val Trp Gly Asn Asn Asn Pro Val Arg 
                645                 650                 655     


Leu Trp Ala Gln Lys Ser Ser Ser Ser Ser Ala His Gly Asn Pro Ile 
            660                 665                 670         


Ser Ile Val Ser His Tyr Tyr Asp Leu Tyr Pro Tyr Trp Thr Ile Thr 
        675                 680                 685             


Val Leu Ala Ser Leu Gly Leu Leu Ile Val Ile Ser Ser Gly Phe Ser 
    690                 695                 700                 


Cys Phe Leu Cys Ser Val Ala Arg Thr Lys Cys Leu Thr Pro Tyr Gln 
705                 710                 715                 720 


Leu Ala Pro Gly Ala Gln Leu Pro Thr Phe Ile Ala Leu Leu Cys Cys 
                725                 730                 735     


Ala Lys Ser Ala Arg Ala Asp Thr Leu Asp Asp Phe Ser Tyr Leu Trp 
            740                 745                 750         


Thr Asn Asn Gln Ala Met Phe Trp Leu Gln Leu Ala Ser Pro Val Ala 
        755                 760                 765             


Ala Phe Leu Cys Leu Ser Tyr Cys Cys Arg Asn Leu Ala Cys Cys Met 
    770                 775                 780                 


Lys Ile Phe Leu Gly Ile Ser Gly Leu Cys Val Ile Ala Thr Gln Ala 
785                 790                 795                 800 


Tyr Glu His Ser Thr Thr Met Pro Asn Gln Val Gly Ile Pro Phe Lys 
                805                 810                 815     


Ala Leu Ile Glu Arg Pro Gly Tyr Ala Gly Leu Pro Leu Ser Leu Val 
            820                 825                 830         


Val Ile Lys Ser Glu Leu Val Pro Ser Leu Val Gln Asp Tyr Ile Thr 
        835                 840                 845             


Cys Asn Tyr Lys Thr Val Val Pro Ser Pro Tyr Ile Lys Cys Cys Gly 
    850                 855                 860                 


Gly Ala Glu Cys Ser His Lys Asn Glu Ala Asp Tyr Lys Cys Ser Val 
865                 870                 875                 880 


Phe Thr Gly Val Tyr Pro Phe Met Trp Gly Gly Ala Tyr Cys Phe Cys 
                885                 890                 895     


Asp Thr Glu Asn Ser Gln Met Ser Glu Val Tyr Val Thr Arg Gly Glu 
            900                 905                 910         


Ser Cys Glu Ala Asp His Ala Ile Ala Tyr Gln Val His Thr Ala Ser 
        915                 920                 925             


Leu Lys Ala Gln Val Met Ile Ser Ile Gly Glu Leu Asn Gln Thr Val 
    930                 935                 940                 


Asp Val Phe Val Asn Gly Asp Ser Pro Ala Arg Ile Gln Gln Ser Lys 
945                 950                 955                 960 


Phe Ile Leu Gly Pro Ile Ser Ser Ala Trp Ser Pro Phe Asp His Lys 
                965                 970                 975     


Val Ile Val Tyr Arg Asp Glu Val Tyr Asn Glu Asp Tyr Ala Pro Tyr 
            980                 985                 990         


Gly Ser Gly Gln Ala Gly Arg Phe  Gly Asp Ile Gln Ser  Arg Thr Val 
        995                 1000                 1005             


Asn Ser  Thr Asp Val Tyr Ala  Asn Thr Asn Leu Lys  Leu Lys Arg 
    1010                 1015                 1020             


Pro Ala  Ser Gly Asn Val His  Val Pro Tyr Thr Gln  Thr Pro Ser 
    1025                 1030                 1035             


Gly Phe  Ser Tyr Trp Lys Lys  Glu Lys Gly Val Pro  Leu Asn Arg 
    1040                 1045                 1050             


Asn Ala  Pro Phe Gly Cys Ile  Ile Lys Val Asn Pro  Val Arg Ala 
    1055                 1060                 1065             


Glu Asn  Cys Val Tyr Gly Asn  Ile Pro Ile Ser Met  Asp Ile Ala 
    1070                 1075                 1080             


Asp Ala  His Phe Thr Arg Ile  Asp Glu Ser Pro Ser  Val Ser Leu 
    1085                 1090                 1095             


Lys Ala  Cys Glu Val Gln Ser  Cys Thr Tyr Ser Ser  Asp Phe Gly 
    1100                 1105                 1110             


Gly Val  Ala Ser Ile Ser Tyr  Thr Ser Asn Lys Val  Gly Lys Cys 
    1115                 1120                 1125             


Ala Ile  His Ser His Ser Asn  Ser Ala Thr Met Lys  Asp Ser Val 
    1130                 1135                 1140             


Gln Asp  Val Gln Glu Ser Gly  Ala Leu Ser Leu Phe  Phe Ala Thr 
    1145                 1150                 1155             


Ser Ser  Val Glu Pro Asn Phe  Val Val Gln Val Cys  Asn Ala Arg 
    1160                 1165                 1170             


Ile Thr  Cys His Gly Lys Cys  Glu Pro Pro Lys Asp  His Ile Val 
    1175                 1180                 1185             


Pro Tyr  Ala Ala Lys His Asn  Asp Ala Glu Phe Pro  Ser Ile Ser 
    1190                 1195                 1200             


Thr Thr  Ala Trp Gln Trp Leu  Ala His Thr Thr Ser  Gly Pro Leu 
    1205                 1210                 1215             


Thr Ile  Leu Val Val Ala Ile  Ile Val Val Val Val  Val Ser Ile 
    1220                 1225                 1230             


Val Val  Cys Ala Arg His 
    1235                 


<210>  213
<211>  675
<212>  PRT
<213>  Aura virus

<400>  213

Ser Arg Ala Thr Ala Met Cys Asn Val Thr Cys Asp Arg Thr Cys Tyr 
1               5                   10                  15      


Asn Arg Asn Asp Thr Thr Met Thr Asn Val Asn His Ser Tyr Asp Val 
            20                  25                  30          


Asp Ala Ala Arg Cys Thr Arg Arg His Val Arg Ser Thr Thr Asp Asp 
        35                  40                  45              


Thr Thr Ala Tyr Gly Cys His Arg Cys Lys Thr Met Cys Tyr Ser Lys 
    50                  55                  60                  


Lys Val Trp Asp Asp Ala Asp Asp Gly Val Arg Val Ser Ala Gly Tyr 
65                  70                  75                  80  


Asn Arg Ala Gly Thr Ala Ala Ser Ala Arg Arg Met Gly Gly Gly Val 
                85                  90                  95      


Gly Ala Ala Asp Lys Val Thr Ser Lys Cys His Ser His Lys Gly Tyr 
            100                 105                 110         


Val Val Lys Cys Gly Asp Ser Thr Thr Ser Lys Val His Gly Ser Asp 
        115                 120                 125             


Thr Cys Thr Met Arg Val Gly Tyr Lys Val Gly Arg Lys Tyr Thr Met 
    130                 135                 140                 


His Gly Thr Cys Thr Tyr Arg Thr Arg Lys Ser Ala Gly Tyr Val Thr 
145                 150                 155                 160 


Met His Arg Gly Ser Thr Met Met Ser Gly Gly Val Tyr Val Thr Ser 
                165                 170                 175     


Gly Arg Asn Val Thr Tyr Cys Lys Cys Gly Asp Lys Thr Gly Thr Val 
            180                 185                 190         


Thr Ala Arg Thr Lys Asp Gly Cys Thr Arg Lys Cys Ala Ser Ala Asp 
        195                 200                 205             


His Val Lys Trp Val Asn Ser Asp Arg His Thr Asp His Thr Ala Gly 
    210                 215                 220                 


Lys His Ala Cys Thr Val Ala His Gly Val Lys His Ala Tyr Arg Ser 
225                 230                 235                 240 


Met Ser Thr His Ala His Thr Thr Thr Arg His Gly Asn Thr Ala Trp 
                245                 250                 255     


Val Gly Ser Val Thr Arg Asn Ser Thr Gly Tyr Thr Trp Gly Asn Lys 
            260                 265                 270         


Val Arg Val Tyr Ala Ser Ala Gly Asn His Gly Trp His Val Arg His 
        275                 280                 285             


Tyr Tyr His Tyr Tyr Thr Val Thr Val Ser Gly Met Gly Ala Cys Ala 
    290                 295                 300                 


Gly Val Ser Cys Cys Cys Lys Ala Arg Arg Asp Cys Thr Tyr Ala Asn 
305                 310                 315                 320 


Ala Thr Val Val Thr Cys Cys Cys Arg Thr Ser Ala Asp Thr Asp Thr 
                325                 330                 335     


Met Gly Tyr Trp His Ser Thr Met Trp Val Ala Ala Val Thr Val Arg 
            340                 345                 350         


Cys Cys Ser Cys Cys Val Ala Ser Asn Lys Ala Asp Ala Tyr His Thr 
        355                 360                 365             


Thr Val Asn Ala Asn Ser Tyr Lys Ala Val Arg Gly Tyr Ala Asn Val 
    370                 375                 380                 


Met Val Met Asn Thr Ser Val Lys Arg Tyr Thr Cys Arg Tyr His Thr 
385                 390                 395                 400 


Val Val Ser Lys Cys Cys Gly Thr Val Cys Lys Gly Lys Ala Asp Tyr 
                405                 410                 415     


Thr Cys Lys Val Thr Gly Val Tyr Trp Gly Gly Ala Cys Cys Asp Ser 
            420                 425                 430         


Asn Ser Ser Asp Lys Tyr Val Ser Thr Asp Cys Ala Thr Asp His Ala 
        435                 440                 445             


Ala Val Arg Val His Thr Ala Ser Val Lys Ser Arg Thr Tyr Gly Asn 
    450                 455                 460                 


Ser Thr Ala Val Asp Val Val Asn Gly Val Thr Ala Arg Ser Lys Asp 
465                 470                 475                 480 


Met Lys Ala Gly Ser Thr Thr Ser Asp Asn Lys Val Tyr His Gly Lys 
                485                 490                 495     


Val Tyr Asn Tyr Asp Gly Ala Gly Thr Gly Ala Gly Asp Val Ala Ser 
            500                 505                 510         


Ser Thr Thr Gly Ser Asp Ala Asn Thr Ala His Arg Ala Arg Asn His 
        515                 520                 525             


Val Tyr Thr Ala Ser Gly Trp Lys Asn Asn Ser Gly Ser Asp Thr Ala 
    530                 535                 540                 


Gly Cys Lys Val Asn Val Asn Arg Ala Asp Lys Cys Ala Val Gly Ser 
545                 550                 555                 560 


Ser Val Asp Asp Ala Ala Thr Arg Val Ser Ser Lys Cys Thr Val Thr 
                565                 570                 575     


Ser Cys Thr Tyr Ser Thr Asp Tyr Gly Gly Val Val Thr Tyr Ser Asp 
            580                 585                 590         


Arg Ala Gly Cys Ala Val His Ser His Ser Ser Thr Ala Val Arg Asp 
        595                 600                 605             


Ser Val Tyr Val Lys Gly Thr Thr Lys Ser Thr Arg Ser Ala Asp Val 
    610                 615                 620                 


Ser Met Cys Gly Thr Arg Thr Thr Cys His Ala Cys Thr His Val Met 
625                 630                 635                 640 


Asn Arg Lys Ser Thr Asp Ser Ser Ala Ser Lys Thr Ser Trp Asn Trp 
                645                 650                 655     


Thr Ala Met Gly Gly Ser Ser Ala Ala Ala Ala Val Val Ala Val Thr 
            660                 665                 670         


Ala His Arg 
        675 


<210>  214
<211>  252
<212>  PRT
<213>  Bebaru Virus

<400>  214

Gly Ala Tyr Cys Cys Asp Ala Asn Ser Ser Ala Tyr Val Val Arg Ser 
1               5                   10                  15      


Met Cys Lys Asp His Ala Val Ala Tyr Arg Ala His Thr Ala Ser Lys 
            20                  25                  30          


Ala Lys Val Arg Val Ser Gly Ser Val Asn Thr Val Thr Val Asn Gly 
        35                  40                  45              


Ser Lys Ala Lys Val Ser Gly Ser Met Gly Val Ser Thr Ala Trp Thr 
    50                  55                  60                  


Asp Asn Lys Val Val Tyr Lys Asp Val Asn Asp Tyr Gly Ser Gly Gly 
65                  70                  75                  80  


Arg Gly Asp Ser Arg Thr Thr Thr Ser Lys Asp Tyr Ala Asn Thr Ala 
                85                  90                  95      


Lys Ala Arg Ser Ala Gly Thr His Val Tyr Thr Thr Ser Gly Arg Tyr 
            100                 105                 110         


Trp Lys Lys Gly Ser Ala Asn Ser Lys Ala Gly Cys Lys Thr Gly Val 
        115                 120                 125             


Arg Ala Met Asn Cys Ala Val Gly Asn Val Ser Asp Asp Ala Val Thr 
    130                 135                 140                 


Arg Thr Asp Ser Ala Thr Thr Cys Thr Val Ala Ser Cys Thr His Ser 
145                 150                 155                 160 


Ser Asp Gly Gly Val Ala Ser Ala Lys Thr Asp Lys Ala Gly Lys Cys 
                165                 170                 175     


Ala Val His Ser His Ser Asn Val Ala Thr Val Ala Asp Val Asp Val 
            180                 185                 190         


Thr Thr Gly Lys Val Ala His Ser Thr Ala Ser Ala Ser Ser Thr Val 
        195                 200                 205             


Ser Cys Ala Ala Arg Ala Asn Cys Arg Ala Ser Cys Lys Asp His Val 
    210                 215                 220                 


Tyr Ala Ala Lys His Asn Asn Val Val Asp Val Ser Gly Thr Ala Gly 
225                 230                 235                 240 


Trp Val Lys Val Ala Gly Gly Thr Gly Ala Val Ala 
                245                 250         


<210>  215
<211>  712
<212>  PRT
<213>  Middleburg virus

<400>  215

Thr Ala Val Thr Thr Ala Cys Ser Asn Thr Asp Cys Ser Cys Ala Cys 
1               5                   10                  15      


Cys Tyr Lys Asp Ala Gly Thr Arg Met Asp Asn Val Asp Asn Gly Tyr 
            20                  25                  30          


Tyr Asp Ala Ala Ser Thr His Cys Asp Ala Arg Arg Arg Arg Arg Gly 
        35                  40                  45              


Thr Asp Tyr Lys Ala Tyr Lys Thr Lys Tyr Ala Tyr Cys Ser Asp Cys 
    50                  55                  60                  


Gly Asn Gly Cys Tyr Ser Ala Arg Val Arg Ala Ala Ser Asp Gly Met 
65                  70                  75                  80  


Lys Ser Ala Gly Val Asp Gly Ala His Ser Trp Thr Lys Arg Tyr Met 
                85                  90                  95      


Lys Gly His Asp Val Asp Thr Asp Arg Asn Ser Val Thr Thr Gly Cys 
            100                 105                 110         


Thr Val His Gly Thr Met Gly His Val Ala Thr Cys Gly Asp Ser Thr 
        115                 120                 125             


Val Ala Val Asp Lys His Lys Val Arg His Ala Cys Arg Ala Tyr Lys 
    130                 135                 140                 


His Arg Val Val Gly Arg His Thr Val Arg His His Gly Val Cys Thr 
145                 150                 155                 160 


Thr Tyr Ala Met Arg Thr Ser Val Thr Thr Met His Val Ala His Asp 
                165                 170                 175     


Val Asp Asn Thr Ser Lys Thr Gly Asn Lys Val Lys Thr Lys Gly Lys 
            180                 185                 190         


Ser Arg Tyr Asn Cys Thr Cys Gly Ser Lys Ser Gly Val Thr Lys Asp 
        195                 200                 205             


Lys Asp Asn Cys Val Ser Cys His Thr Met Val Thr Ala His Asp Lys 
    210                 215                 220                 


Trp Asn Ser Tyr Val Arg Ala Gly Ser Gly Lys Lys Gly Lys His Val 
225                 230                 235                 240 


Ser Asn Ser Thr Cys Arg Val Ala Asn Thr Ala Lys Asn Gly Thr His 
                245                 250                 255     


Val Ala Thr Thr Tyr Arg Thr Gly Lys His His Thr Trp Ser Ser Cys 
            260                 265                 270         


Arg Thr Val Gly Tyr Thr Trp Gly Asn His Ala Val Arg Trp Ala Thr 
        275                 280                 285             


Thr Lys Gly Ser Ala His Gly Met His Ser Tyr Tyr Tyr Gly Tyr Ala 
    290                 295                 300                 


Thr Thr Val Ala Val Cys Val Gly Ala Cys Val Ala Ser Ala Ser Cys 
305                 310                 315                 320 


Cys Cys Val Ser Ala Arg Asn Lys Cys Thr Tyr Ala Thr Gly Ala Val 
                325                 330                 335     


Val Cys Thr Ser Cys Cys Ala Arg Ala Lys Ala Ala Thr Ala Thr Ala 
            340                 345                 350         


Ala Tyr Trp Ala Asn Thr Val Trp Met Ala Val Ala Cys Met Val Thr 
        355                 360                 365             


Tyr Cys Arg His Met Cys Cys Arg Thr Ala Ser Val Ala Val Ser Gly 
    370                 375                 380                 


Met Gly Ala Thr Ala Tyr His Ser Val Thr Asn Ala Val Gly Tyr Arg 
385                 390                 395                 400 


Ala His Val Asp Arg Gly Ser Thr His Met Val Val Ser Thr Ser Thr 
                405                 410                 415     


Ala Asp Tyr Val Thr Cys Tyr Lys Thr Val Val Ser Lys Val Thr Cys 
            420                 425                 430         


Cys Gly Met Ser Cys Ala His Lys Ala Asp Cys Lys Val Tyr Thr Gly 
        435                 440                 445             


Val Tyr Trp Gly Gly Ala Tyr Cys Cys Asp Ser Asn Thr Ser Ala Tyr 
    450                 455                 460                 


Val Arg Ser Val Cys Lys His Asp His Ala Ala Ala Tyr Arg Ala His 
465                 470                 475                 480 


Thr Ala Ala Lys Ala Lys Ser Val Thr Tyr Gly Ser Thr Asn Gly Thr 
                485                 490                 495     


Ala Ala Val Asn Gly Ser Thr Ala Arg Gly Asp Lys Met Gly Ser Thr 
            500                 505                 510         


Ala Trp Ser Asp Lys Val Val Tyr Lys Asp Val Tyr Asn Asp Tyr Tyr 
        515                 520                 525             


Gly Ser Gly Gly Arg Gly Asp Ser Arg Thr Thr Ser Asn Asp Val Tyr 
    530                 535                 540                 


Ala Asn Thr Ala Lys Ala Arg Ser Ala Gly Thr Val His Val Tyr Thr 
545                 550                 555                 560 


Thr Ser Gly Lys Tyr Trp Lys Lys Gly Asp Ala Asn His Lys Ala Gly 
                565                 570                 575     


Cys Lys Thr Asn Val Arg Ala Asn Cys Ala Val Gly Asn Val Ser Asp 
            580                 585                 590         


Asp Ala Ala Thr Arg Val Asp Ala Ser Thr Gly Lys Cys Val Ala Thr 
        595                 600                 605             


Cys Thr His Ser Ser Asp Gly Gly Thr Val Val Tyr Lys Thr Asp Lys 
    610                 615                 620                 


Val Gly Thr Cys Ala Val His Ser Ser Asn Thr Ala Val Met Thr Ser 
625                 630                 635                 640 


Ser Val Thr Met Asp Gly Arg Gly Thr His Ser Thr Ala Ser Ala Ser 
                645                 650                 655     


Ser Val Lys Val Cys Ser Ser Lys Thr Thr Cys Thr Ala Lys Cys Val 
            660                 665                 670         


Lys Asp His Val Val Ala Asn His Asn Asn Val Val Asp Ser Ser Thr 
        675                 680                 685             


Ala Val Ser Trp Thr His Thr Met Gly Gly Ala Thr Val Val Ala Gly 
    690                 695                 700                 


Thr Val Thr Cys Ala Ser Arg His 
705                 710         


<210>  216
<211>  271
<212>  PRT
<213>  Mucambo virus

<400>  216

Leu Val Thr Thr Met Cys Leu Leu Ala Asn Val Thr Phe Pro Cys Ser 
1               5                   10                  15      


Thr Pro Pro Ile Cys Tyr Asp Arg Ala Pro Ala Glu Thr Leu Met Met 
            20                  25                  30          


Leu Ser Lys Asn Ile Asp Asn Pro Gly Tyr Asp Glu Leu Leu Glu Ala 
        35                  40                  45              


Val Leu Lys Cys Pro Gly Arg Gln Lys Arg Ser Thr Glu Glu Leu Phe 
    50                  55                  60                  


Lys Glu Tyr Lys Leu Thr Arg Pro Tyr Met Ala Lys Cys Val Arg Cys 
65                  70                  75                  80  


Ala Val Gly Ser Cys His Ser Pro Ile Ala Ile Glu Ala Val Arg Ser 
                85                  90                  95      


Asp Gly His Asp Gly Tyr Ile Arg Ile Gln Thr Ser Ser Gln Tyr Gly 
            100                 105                 110         


Leu Asp Pro Ser Gly Asn Val Lys Ser Arg Val Met Arg Tyr Asn Leu 
        115                 120                 125             


Tyr Gly Lys Ile Val Glu Val Pro Leu His Gln Val Ser Leu His Thr 
    130                 135                 140                 


Ser Arg Pro Cys His Ile Ile Asp Gly His Gly Tyr Phe Leu Leu Ala 
145                 150                 155                 160 


Arg Cys Pro Glu Gly Asp Ser Ile Thr Met Glu Phe Lys Lys Asp Ser 
                165                 170                 175     


Val Thr His Ser Cys Ser Val Pro Tyr Glu Val Lys Phe Thr Pro Val 
            180                 185                 190         


Gly Arg Glu Leu Tyr Ser His Pro Pro Glu His Gly Thr Glu His Pro 
        195                 200                 205             


Cys Arg Val Tyr Ala His Asp Ala Gln Gln Lys Asp Ala Tyr Val Glu 
    210                 215                 220                 


Met His Leu Pro Gly Ser Glu Val Asp Ser Ser Leu Leu Ser Met Ser 
225                 230                 235                 240 


Gly Ser Ala Val Arg Val Thr Pro Pro Ser Gly Gln Ser Val Leu Val 
                245                 250                 255     


Glu Cys Asn Cys Gly Ser Ala Val Ser Glu Thr Ile Asn Thr Ala 
            260                 265                 270     


<210>  217
<211>  343
<212>  PRT
<213>  Ndumu Virus

<400>  217

Gly Ala Tyr Cys Phe Cys Ser Ser Glu Asn Thr Gln Met Ser Glu Ala 
1               5                   10                  15      


Tyr Val Glu Arg Ala Glu Val Cys Lys His Glu His Ala Leu Ala Tyr 
            20                  25                  30          


Lys Thr Gln Thr Ala Ser Leu Thr Ala Thr Leu Lys Val Thr Leu Gly 
        35                  40                  45              


Asn Ile Thr Gln Gly Ala Lys Ala Tyr Val Asn Gly Glu Thr Pro Phe 
    50                  55                  60                  


Gln Ile Gly Gln Ala Lys Phe Val Leu Gly Pro Ile Ser Ala Ala Trp 
65                  70                  75                  80  


Ser Pro Phe Asn Pro Lys Ile Val Val Tyr Lys Asp Asp Val Tyr Asn 
                85                  90                  95      


Tyr Asp Phe Pro Ala Tyr Gly Ala Gly Gln Pro Gly Arg Phe Gly Asp 
            100                 105                 110         


Ile Gln Ser Arg Thr Val Asp Ser Lys Asp Leu Tyr Ala Arg Thr His 
        115                 120                 125             


Leu Arg Leu Asp Arg Pro Ala Ser Gly Asn Ile His Val Pro Tyr Thr 
    130                 135                 140                 


Gln Ile Pro Ser Glu Phe Lys Tyr Trp Met Gln Glu Lys Gly Glu Pro 
145                 150                 155                 160 


Leu Asn Arg Gln Ala Ala Phe Gly Cys Val Val Lys Thr Asn Pro Val 
                165                 170                 175     


Arg Ala Asp Asn Cys Ala Tyr Gly Asn Ile Pro Ile Ser Val Asp Ile 
            180                 185                 190         


Pro Asp Ala Met Phe Thr Arg Val Val Asp Ile Pro Ala Val Ser His 
        195                 200                 205             


Leu Gln Cys Ile Asp Val Ser Cys Ala His Ser Ala Gly Phe Gly Gly 
    210                 215                 220                 


Val Ala Lys Leu Arg Phe Met Ala Asp Arg Thr Gly Lys Cys Ala Ile 
225                 230                 235                 240 


His Thr Ala Ser Lys Ile Val Ala Ile Gln Glu Ala Thr Val Asp Leu 
                245                 250                 255     


Pro Glu Ile Ala Val Gly Ala Gly Gly Gly Thr Ala Glu Ile Thr Phe 
            260                 265                 270         


His Tyr Ser Thr Ala Leu Ala Ser Pro Ser Phe Asp Val Gln Leu Cys 
        275                 280                 285             


Ser Ala His Val Thr Cys Asp Thr Lys Cys Glu Pro Pro Lys Asp His 
    290                 295                 300                 


Ile Val Pro Phe Ala Ala Gln His Met Ser Asn Asp Met Pro Asn Leu 
305                 310                 315                 320 


Ser Ala Thr Ala Met Asn Trp Val Thr Gly Leu Gly Thr Ser Ile Gly 
                325                 330                 335     


Thr Phe Val Phe Leu Phe Leu 
            340             


<210>  218
<211>  987
<212>  PRT
<213>  O'nyong-nyong virus

<400>  218

Ser Leu Ala Leu Pro Val Met Cys Leu Leu Ala Asn Thr Thr Phe Pro 
1               5                   10                  15      


Cys Ser Gln Pro Pro Cys Ala Pro Cys Cys Tyr Glu Lys Lys Pro Glu 
            20                  25                  30          


Glu Thr Leu Arg Met Leu Glu Asp Asn Val Met Gln Pro Gly Tyr Tyr 
        35                  40                  45              


Gln Leu Leu Asp Ser Ala Leu Ala Cys Ser Gln His Arg Gln Arg Arg 
    50                  55                  60                  


Asn Ala Arg Glu Asn Phe Asn Val Tyr Lys Val Thr Arg Pro Tyr Leu 
65                  70                  75                  80  


Ala His Cys Pro Asp Cys Gly Glu Gly His Ser Cys His Ser Pro Ile 
                85                  90                  95      


Ala Leu Glu Arg Ile Arg Ser Glu Ala Thr Asp Gly Thr Leu Lys Ile 
            100                 105                 110         


Gln Val Ser Leu Gln Ile Gly Ile Lys Thr Ala Asp Ser His Asp Trp 
        115                 120                 125             


Thr Lys Leu Arg Tyr Met Asp Ser His Thr Pro Val Asp Ala Asp Arg 
    130                 135                 140                 


Ser Gly Leu Phe Val Arg Thr Ser Ala Pro Cys Thr Ile Thr Gly Thr 
145                 150                 155                 160 


Met Gly His Phe Ile Leu Ala Arg Cys Pro Lys Gly Glu Thr Leu Thr 
                165                 170                 175     


Val Gly Phe Val Asp Ser Arg Arg Ile Ser His Thr Cys Met His Pro 
            180                 185                 190         


Phe His His Glu Pro Pro Leu Ile Gly Arg Glu Lys Phe His Ser Arg 
        195                 200                 205             


Pro Gln His Gly Lys Glu Leu Pro Cys Ser Thr Tyr Val His Thr Thr 
    210                 215                 220                 


Ala Ala Thr Thr Glu Glu Ile Glu Val His Met Pro Pro Asp Thr Pro 
225                 230                 235                 240 


Asp Tyr Thr Leu Met Thr Gln Gln Ala Gly Asn Val Lys Ile Thr Val 
                245                 250                 255     


Asp Gly Gln Thr Val Arg Tyr Lys Cys Lys Cys Asp Gly Ser Asn Glu 
            260                 265                 270         


Gly Leu Ile Thr Thr Asp Lys Val Ile Asn Asn Cys Lys Val Asp Gln 
        275                 280                 285             


Cys His Thr Ala Val Thr Asn His Lys Lys Trp Gln Tyr Asn Ser Pro 
    290                 295                 300                 


Leu Thr Pro Arg Asn Ser Glu Gln Gly Asp Arg Lys Gly Lys Ile His 
305                 310                 315                 320 


Ile Pro Phe Pro Leu Val Asn Thr Thr Cys Arg Val Pro Lys Ala Arg 
                325                 330                 335     


Asn Pro Thr Val Thr Tyr Gly Lys Asn Arg Val Thr Leu Leu Leu Tyr 
            340                 345                 350         


Pro Asp His Pro Thr Leu Leu Ser Tyr Arg Ala Met Gly Arg Ile Pro 
        355                 360                 365             


Asp Tyr His Glu Glu Trp Ile Thr Ser Lys Lys Glu Ile Ser Ile Thr 
    370                 375                 380                 


Val Pro Ala Glu Gly Leu Glu Val Thr Trp Gly Asn Asn Asp Pro Tyr 
385                 390                 395                 400 


Lys Tyr Trp Pro Gln Leu Ser Thr Asn Gly Thr Ala His Gly His Pro 
                405                 410                 415     


His Glu Ile Ile Leu Tyr Tyr Tyr Glu Leu Tyr Pro Thr Thr Thr Ile 
            420                 425                 430         


Ala Val Leu Ala Ala Ala Ser Ile Val Val Ala Ser Leu Val Gly Leu 
        435                 440                 445             


Ser Leu Gly Met Cys Ile Cys Ala Arg Arg Arg Cys Ile Thr Pro Tyr 
    450                 455                 460                 


Glu Leu Thr Pro Gly Ala Thr Ile Pro Phe Leu Leu Gly Ile Leu Cys 
465                 470                 475                 480 


Cys Val Lys Thr Ala Lys Ala Ala Ser Tyr Tyr Glu Ala Ala Thr Tyr 
                485                 490                 495     


Leu Trp Asn Glu Gln Gln Pro Leu Phe Trp Leu Gln Leu Leu Ile Pro 
            500                 505                 510         


Leu Ser Ala Ala Ile Val Val Cys Asn Cys Leu Lys Leu Leu Pro Cys 
        515                 520                 525             


Cys Cys Lys Thr Leu Thr Phe Leu Ala Val Met Ser Ile Gly Ala Arg 
    530                 535                 540                 


Thr Val Ser Ala Tyr Glu His Ala Thr Val Ile Pro Asn Thr Val Gly 
545                 550                 555                 560 


Val Pro Tyr Lys Thr Leu Val Ser Arg Pro Gly Tyr Ser Pro Met Val 
                565                 570                 575     


Leu Glu Met Glu Leu Gln Ser Val Thr Leu Glu Pro Thr Leu Phe Leu 
            580                 585                 590         


Asp Tyr Ile Thr Cys Glu Tyr Lys Thr Ile Thr Pro Ser Pro Tyr Val 
        595                 600                 605             


Lys Cys Cys Gly Thr Ala Glu Cys Lys Ala Lys Asn Leu Pro Asp Tyr 
    610                 615                 620                 


Asn Cys Lys Val Phe Thr Gly Val Tyr Pro Phe Met Trp Gly Gly Ala 
625                 630                 635                 640 


Tyr Cys Phe Cys Asp Ala Glu Asn Thr Gln Leu Ser Glu Ala His Val 
                645                 650                 655     


Glu Lys Ser Glu Ser Cys Lys Thr Glu Phe Ala Ser Ala Tyr Arg Ala 
            660                 665                 670         


His Thr Ala Ser Val Ser Ala Lys Leu Arg Val Phe Tyr Gln Gly Asn 
        675                 680                 685             


Asn Ile Thr Val Ser Ala Tyr Ala Asn Gly Asp His Ala Val Thr Val 
    690                 695                 700                 


Lys Asp Ala Lys Phe Val Ile Gly Pro Leu Ser Ser Ala Trp Ser Pro 
705                 710                 715                 720 


Phe Asp Asn Lys Ile Val Val Tyr Lys Gly Glu Val Tyr Asn Met Asp 
                725                 730                 735     


Tyr Pro Pro Phe Gly Ala Gly Arg Pro Gly Gln Phe Gly Asp Ile Gln 
            740                 745                 750         


Ser Arg Thr Pro Asp Ser Lys Asp Val Tyr Ala Asn Thr Gln Leu Ile 
        755                 760                 765             


Leu Gln Arg Pro Ala Ala Gly Ala Ile His Val Pro Tyr Ser Gln Ala 
    770                 775                 780                 


Pro Ser Gly Phe Lys Tyr Trp Leu Lys Glu Lys Gly Ala Ser Leu Gln 
785                 790                 795                 800 


His Thr Ala Pro Phe Gly Cys Gln Ile Ala Thr Asn Pro Val Arg Ala 
                805                 810                 815     


Val Asn Cys Ala Val Gly Asn Ile Pro Val Ser Ile Asp Ile Pro Asp 
            820                 825                 830         


Ala Ala Phe Thr Arg Val Thr Asp Ala Pro Ser Val Thr Asp Met Ser 
        835                 840                 845             


Cys Glu Val Ala Ser Cys Thr His Ser Ser Asp Phe Gly Gly Ala Ala 
    850                 855                 860                 


Val Ile Lys Tyr Thr Ala Ser Lys Lys Gly Lys Cys Ala Val His Ser 
865                 870                 875                 880 


Leu Thr Asn Ala Val Thr Ile Arg Glu Pro Asn Val Asp Val Glu Gly 
                885                 890                 895     


Thr Ala Gln Leu Gln Ile Ala Phe Ser Thr Ala Leu Ala Ser Ala Glu 
            900                 905                 910         


Phe Lys Val Gln Ile Cys Ser Thr Gln Val His Cys Ser Ala Thr Cys 
        915                 920                 925             


His Pro Pro Lys Asp His Ile Val Asn Tyr Pro Ser Pro His Thr Thr 
    930                 935                 940                 


Leu Gly Val Gln Asp Ile Ser Thr Thr Ala Met Ser Trp Val Gln Lys 
945                 950                 955                 960 


Ile Thr Gly Gly Val Gly Leu Val Val Ala Ile Ala Ala Leu Ile Leu 
                965                 970                 975     


Ile Ile Val Leu Cys Val Ser Phe Ser Arg His 
            980                 985         


<210>  219
<211>  265
<212>  PRT
<213>  Pixuna virus

<400>  219

Leu Val Thr Thr Met Cys Leu Leu Ala Asn Val Ser Phe Pro Cys Ser 
1               5                   10                  15      


Gln Pro Pro Met Cys Tyr Asp His Lys Pro Ala Ala Thr Leu Ala Leu 
            20                  25                  30          


Leu Ser Ala Asn Val Asp Arg Pro Gly Tyr Asp Asp Leu Leu Glu Ala 
        35                  40                  45              


Val Leu Lys Cys Pro Gly Arg Ala Arg Arg Ser Thr Asp Glu Leu Phe 
    50                  55                  60                  


Lys Glu Tyr Lys Leu Thr Arg Pro Tyr Met Ala Lys Cys Ile Arg Cys 
65                  70                  75                  80  


Ala Val Gly Ser Cys His Ser Pro Ile Ala Ile Glu Ala Val Arg Ser 
                85                  90                  95      


Asp Gly His Asp Gly Tyr Val Arg Ile Gln Thr Ser Ser Gln Tyr Gly 
            100                 105                 110         


Leu Asp Pro Ser Gly Ser Val Lys Arg Arg Thr Met Arg Tyr Asn Met 
        115                 120                 125             


His Gly Lys Ile Glu Glu Val Pro Leu His Glu Val Ser Leu His Thr 
    130                 135                 140                 


Ser Arg Pro Cys His Ile Val Asp Gly His Gly Tyr Phe Leu Leu Ala 
145                 150                 155                 160 


Arg Cys Pro Pro Gly Asp Ser Ile Thr Met Glu Phe Lys Lys Glu His 
                165                 170                 175     


Val Thr His Leu Cys Ser Val Pro Tyr Glu Val Arg Phe Thr Pro Val 
            180                 185                 190         


Gly Arg Glu Leu Tyr Thr His Pro Pro Glu His Gly Ala Glu His Pro 
        195                 200                 205             


Cys Arg Val Tyr Ala His Asp Ala Gln His His Gly Ala Tyr Val Glu 
    210                 215                 220                 


Met His Leu Pro Gly Leu Glu Val Asp Ser Thr Met Leu Ser Leu Ser 
225                 230                 235                 240 


Gly Gly Ala Val Gln Ile Thr Pro Pro Thr Gly Lys Thr Ala Phe Val 
                245                 250                 255     


Glu Cys Lys Cys Gly Ala Gln Ile Ser 
            260                 265 


<210>  220
<211>  335
<212>  PRT
<213>  Tonate Virus

<400>  220

Gly Ala Tyr Cys Phe Cys Asp Ser Glu Asn Thr Gln Leu Ser Arg Ala 
1               5                   10                  15      


Tyr Val Thr Lys Ser Asp Asp Cys Ser Ala Asp His Ala Leu Ala Tyr 
            20                  25                  30          


Lys Ala His Thr Ala Ser Val Gln Ala Phe Leu Asn Ile Thr Val Gly 
        35                  40                  45              


Glu Gln Ser Thr Thr Ala Val Val Tyr Val Asn Gly Glu Thr Pro Ile 
    50                  55                  60                  


Ser Phe Asn Gly Ile Arg Leu Val Ala Gly Pro Leu Ser Thr Ala Trp 
65                  70                  75                  80  


Thr Pro Phe Asp Arg Lys Val Val Gln Tyr Ala Gly Glu Ile Tyr Asn 
                85                  90                  95      


Tyr Asp Phe Pro Glu Tyr Gly Ala Gly His Ala Gly Ala Phe Gly Asp 
            100                 105                 110         


Leu Gln Ala Arg Thr Thr Thr Ser Asn Asp Leu Tyr Ala Asn Thr Asn 
        115                 120                 125             


Leu Val Leu Gln Arg Pro Thr Ala Gly Thr Ile His Val Pro Tyr Thr 
    130                 135                 140                 


Gln Ala Pro Ser Gly Phe Glu Gln Trp Lys Lys Asp Lys Pro Pro Ser 
145                 150                 155                 160 


Leu Lys Tyr Thr Ala Pro Phe Gly Cys Glu Ile Tyr Val Asn Pro Val 
                165                 170                 175     


Arg Ala Glu Asn Cys Ala Val Gly Ser Ile Pro Leu Ala Phe Asp Ile 
            180                 185                 190         


Pro Asp Ala Leu Phe Thr Arg Val Ser Glu Thr Pro Thr Leu Ser Asn 
        195                 200                 205             


Ala Glu Cys Ser Leu Asn Glu Cys Val Tyr Ser Ser Asp Phe Gly Gly 
    210                 215                 220                 


Ile Ala Thr Val Lys Tyr Thr Ala Ser Lys Ser Gly Lys Cys Ala Val 
225                 230                 235                 240 


His Ile Pro Ser Gly Thr Ala Thr Leu Lys Glu Ser Leu Val Asp Val 
                245                 250                 255     


Val Glu Gln Gly Ser Leu Thr Leu His Phe Ser Thr Ala Asn Ile His 
            260                 265                 270         


Pro Glu Phe Lys Leu Gln Ile Cys Thr Thr His Leu Thr Cys Lys Gly 
        275                 280                 285             


Asp Cys His Pro Pro Lys Asp His Ile Val Thr His Pro Gln Leu His 
    290                 295                 300                 


Ala Gln Thr Phe Thr Ala Ala Val Ser Lys Thr Ala Trp Thr Trp Leu 
305                 310                 315                 320 


Thr Ser Leu Leu Gly Gly Ser Ala Val Ile Ile Ile Ile Gly Leu 
                325                 330                 335 


<210>  221
<211>  335
<212>  PRT
<213>  Trocara virus


<220>
<221>  misc_feature
<222>  (278)..(278)
<223>  Xaa can be any naturally occurring amino acid

<400>  221

Gly Ala Gln Cys Phe Cys Glu Ser Glu Asn Thr Gln Met Ser Glu Ala 
1               5                   10                  15      


Tyr Val Asp Arg Ser Pro Asp Cys Lys Thr Leu Asn Ala Lys Ala Tyr 
            20                  25                  30          


Arg Ala His Thr Ala Asn Phe Lys Ala Lys Leu Asn Ile Thr Phe Gly 
        35                  40                  45              


Asp Lys Tyr Glu Val Val Glu Ala Phe Ala Asn Gly Val Thr Lys Val 
    50                  55                  60                  


Asn Ala Gly Gln Leu Thr Ala Val Leu Gly Pro Met Ala Ser Pro Trp 
65                  70                  75                  80  


Ser Pro Phe Asp Asn Lys Ile Val Leu Tyr Lys Asp Lys Val Tyr Asn 
                85                  90                  95      


Tyr Asp Phe Pro Glu Tyr Gly Ala Gly Leu Pro Gly Ala Phe Gly Asp 
            100                 105                 110         


Ile Gln Met Met Ser Pro Thr Ser Ala Asp Leu Tyr Ala Arg Thr Asn 
        115                 120                 125             


Leu Lys Leu Leu Arg Pro Asn Ser Gly Gln Ile His Val Pro Tyr Thr 
    130                 135                 140                 


Gln Ala Pro Ser Gly Phe Val His Trp Thr Asn Asn Ser Gly Lys Ser 
145                 150                 155                 160 


Leu Gln Asp Thr Ala Pro Phe Gly Cys Asn Ile Lys Thr Asn Pro Ile 
                165                 170                 175     


Arg Ala Glu Asn Cys Ala Val Gly Ser Ile Pro Val Ser Leu Asp Ile 
            180                 185                 190         


Pro Asp Ala Glu Phe Thr Arg Val Ser Glu Ala Pro His Ile Thr Ser 
        195                 200                 205             


Ala Ser Cys Thr Val Thr Ser Cys Thr Ser Ser Thr Glu Ala Gly Gly 
    210                 215                 220                 


Val Met His Ile Glu Tyr Lys Ala Ala Lys Pro Gly Lys Cys Ala Val 
225                 230                 235                 240 


Gln Ala Leu Ser Ser Val Val Thr Ile Thr Glu Ser Asn Ala Asp Ile 
                245                 250                 255     


Gln Thr Glu Gly Thr Leu Glu Leu His Phe Ser Thr Ala Ala Ile Gln 
            260                 265                 270         


Ala Asp Phe Arg Val Xaa Val Cys Ala Ser Gly Val Gln Cys Thr Gly 
        275                 280                 285             


Pro Cys Arg Pro Pro Lys Glu His Ile Val Ala Lys Pro Gln Leu Thr 
    290                 295                 300                 


Thr Lys Glu Phe Lys Asn Ala Ile Ser Ser Thr Ser Trp Asn Trp Val 
305                 310                 315                 320 


Tyr Ala Leu Leu Gly Ser Thr Ser Ser Leu Leu Leu Val Gly Val 
                325                 330                 335 


<210>  222
<211>  334
<212>  PRT
<213>  Whataroa virus

<400>  222

Gly Ala Gln Cys Phe Cys Asp Thr Glu Asn Thr Gln Met Ser Glu Ala 
1               5                   10                  15      


Tyr Val Glu Arg Ser Ser Asp Cys Ala Val Asp His Ala Gln Ala Leu 
            20                  25                  30          


Lys Val His Thr Ser Ser Met Lys Val Gly Leu Lys Ile Thr Tyr Gly 
        35                  40                  45              


Asn Thr Thr Gly Met Leu Asp Val Phe Val Asn Gly Val Thr Pro Gly 
    50                  55                  60                  


Thr Ser Lys Asp Leu Lys Val Ile Ala Gly Pro Ile Ser Ala Ala Phe 
65                  70                  75                  80  


Ser Pro Phe Asp Ser Lys Val Val Val Tyr Lys Gly Met Val Tyr Asn 
                85                  90                  95      


Tyr Asp Phe Pro Glu Phe Gly Ala Met Lys Pro Gly Val Phe Gly Asp 
            100                 105                 110         


Ile Gln Ala Ser Ser Pro Thr Ser Asn Asp Leu Val Ala Asn Thr Asp 
        115                 120                 125             


Ile Arg Leu Leu Arg Pro Ile Ala Arg Asn Val His Val Pro Tyr Thr 
    130                 135                 140                 


Gln Ala Ala Ser Gly Phe Glu Met Trp Lys Asn Asn Ser Gly Arg Pro 
145                 150                 155                 160 


Leu Gln Glu Thr Ala Pro Phe Gly Cys Lys Val Gln Thr Asn Pro Leu 
                165                 170                 175     


Arg Ala Ser Asp Cys Ala Tyr Gly Asn Ile Pro Ile Ser Leu Asp Ile 
            180                 185                 190         


Pro Asn Ala Ala Phe Met Arg Ile Ser Asp Ala Pro Leu Ile Ser Ala 
        195                 200                 205             


Ala Thr Cys Thr Val Ser Glu Cys Ile Tyr Ser Ala Asp Tyr Gly Gly 
    210                 215                 220                 


Met Ala Ser Ile Gln Tyr Thr Ser Asp Arg Glu Gly Gln Cys Pro Val 
225                 230                 235                 240 


His Ser His Ser Ser Thr Ala Ser Leu Gln Glu Ser Thr Val His Val 
                245                 250                 255     


Val Gln Ser Gly Thr Val Thr Val His Phe Ser Thr Ala Ser Pro Gln 
            260                 265                 270         


Ala Asn Phe Val Ile Ser Leu Cys Gly Lys Lys Thr Ile Cys His Ala 
        275                 280                 285             


Glu Cys Lys Pro Pro Ala Asp His Ile Val Lys Thr Pro His Lys Asn 
    290                 295                 300                 


Asp Gln Glu Phe Arg Ser Ala Val Ser Thr Thr Ser Trp Ser Trp Leu 
305                 310                 315                 320 


Phe Ala Leu Phe Gly Gly Ala Ser Ser Leu Ile Phe Ile Gly 
                325                 330                 


<210>  223
<211>  668
<212>  PRT
<213>  Bussuquara virus

<400>  223

Phe Lys Val Val Thr Gly Pro Glu Gly Pro Ile Met Asp Val Thr Lys 
1               5                   10                  15      


Lys Asp Val Gly Lys Ala Leu Glu Ile Pro Phe Gln Asn Phe Asn Asn 
            20                  25                  30          


Thr Cys Trp Val Met Ala Met Asp Val Gly His Pro Cys Glu Asp Thr 
        35                  40                  45              


Ile Glu Tyr Glu Cys Pro Ser Leu Asp Ile Gly Ala Glu Pro Asn Asp 
    50                  55                  60                  


Ile Asp Cys Trp Cys Asp Thr Met Pro Met Arg Val Arg Tyr Gly Arg 
65                  70                  75                  80  


Cys Thr Lys Gly Ser Ile Pro Lys Arg Ser Arg Arg Asn Ala Val Phe 
                85                  90                  95      


Pro Gln His Thr Glu Asn Val Leu Ala Thr Arg Gln Glu Thr Trp Met 
            100                 105                 110         


Asn Thr Asp Val Ile Met Lys His Leu Ile Lys Val Glu Thr Trp Ala 
        115                 120                 125             


Leu Arg Asn Pro Gly Phe Ala Leu Val Ala Ile Thr Leu Gly Trp Met 
    130                 135                 140                 


Leu Gly Ser Asn Arg Ser Gln Lys Ile Ile Phe Thr Ile Leu Leu Leu 
145                 150                 155                 160 


Leu Val Ala Pro Ala Tyr Asn Met Arg Cys Ile Gly Val Glu Asn Arg 
                165                 170                 175     


Asp Phe Val Glu Gly Leu Ser Gly Gly Thr Trp Val Asp Val Val Leu 
            180                 185                 190         


Glu His Gly Gly Cys Val Thr Val Arg Val Glu Gly Lys Pro Thr Leu 
        195                 200                 205             


Asp Phe Glu Leu Val Gln Thr Lys Ala Thr Gly Leu Ala Ala Val Arg 
    210                 215                 220                 


Ala Tyr Cys Tyr Gln Ala Lys Val Ser Asp Ile Gln Ile Ser Ala Ala 
225                 230                 235                 240 


Cys Pro Ala Val Gln Leu Thr Glu Asn Ser Lys Ala Thr Asp Ser Asn 
                245                 250                 255     


Tyr Leu Cys Arg Arg Gly Val Thr Asn Arg Gly Trp Asn Asn Gly Cys 
            260                 265                 270         


Gly Leu Phe Gly Lys Gly Asp Ile His Thr Cys Val Lys Phe Lys Cys 
        275                 280                 285             


Glu Lys Lys Ala Ala Gly Phe Ser Ile Gly Lys Glu Asn Leu Glu Tyr 
    290                 295                 300                 


Glu Val Arg Ala Ser Val His Asn Ser Ile Gly Ala Asp Lys Phe Ser 
305                 310                 315                 320 


Asn Glu Leu Ala Asp Gly Glu Pro His Thr Gln Lys Met Lys Phe Ser 
                325                 330                 335     


Pro Leu Ser Pro Ser Ala Glu Lys Ser Phe Gly Asp Tyr Gly Thr Leu 
            340                 345                 350         


Gly Met Asp Cys Glu Pro Gln Ser Gly Leu Asp Phe Gly Gln Leu Tyr 
        355                 360                 365             


Leu Met Thr Ile Glu Ser Lys Ser Trp Leu Val Asn Arg Asp Trp Tyr 
    370                 375                 380                 


His Asp Leu His Leu Pro Tyr Thr Val Gly Ser Gly Ser Gln Trp Asn 
385                 390                 395                 400 


Asn Arg Glu Ala Leu Val Glu Phe Gln Glu Pro His Ala Thr Lys Gln 
                405                 410                 415     


Glu Val Leu Ala Leu Gly Ser Gln Glu Gly Ala Leu His Ser Ala Leu 
            420                 425                 430         


Ala Gly Ala Ile Met Ala Asn Arg Glu Thr Ser Ser Pro His Ala Leu 
        435                 440                 445             


Leu Leu Thr Ala Gly His Leu Lys Cys Arg Ile Lys Met Asp Lys Met 
    450                 455                 460                 


Val Ile Lys Gly Ile Thr Tyr Gly Gln Cys Ser Gly Thr Phe Lys Met 
465                 470                 475                 480 


Glu Lys His Pro Ala Asp Thr Gly His Gly Thr Val Val Leu Asp Val 
                485                 490                 495     


Ser Tyr Gln Gly Asp Asp Ala Pro Cys Lys Ile Pro Ile Val Ile Thr 
            500                 505                 510         


Ser Asn Leu Ala Glu Val Glu Pro Val Gly Arg Leu Val Ser Ala His 
        515                 520                 525             


Pro Val Ile Thr Ala Lys Asn Val Arg Thr Met Leu Glu Val Glu Pro 
    530                 535                 540                 


Pro Tyr Gly Asp Ser Tyr Ile Val Ile Gly Val Gly Asp Gly Arg Leu 
545                 550                 555                 560 


Lys Gln His Trp Phe Lys Lys Gly Ser Val Ile Gly Gly Ala Phe Ser 
                565                 570                 575     


Thr Thr Met Lys Gly Ala Lys Arg Leu Ala Val Leu Gly Asp Ala Ala 
            580                 585                 590         


Trp Asp Phe Gly Ser Val Gly Gly Val Phe Asn Ser Leu Gly Lys Ala 
        595                 600                 605             


Val His Gln Leu Phe Gly Gly Ile Phe Arg Thr Leu Phe Gly Gly Met 
    610                 615                 620                 


Ser Trp Leu Ser Arg Leu Met Ile Gly Ala Leu Cys Leu Trp Ile Gly 
625                 630                 635                 640 


Ile Asn Ala Arg Asp His Ser Ile Ala Val Thr Met Leu Ser Val Gly 
                645                 650                 655     


Gly Ile Leu Ile Phe Leu Ser Ile Asn Val Ser Ala 
            660                 665             


<210>  224
<211>  271
<212>  PRT
<213>  Jugra virus

<400>  224

Phe Thr Ser Thr Gly His Met Asp Val Tyr Glu Met Asp Met Thr Lys 
1               5                   10                  15      


Val Glu Tyr Thr Ile Lys Thr Gln Val His Ser Gly Ala Lys Ser Gly 
            20                  25                  30          


Asp Ala Thr Leu Val Lys Ser Ile Lys Phe Thr Pro Val Ser Gly Thr 
        35                  40                  45              


Gln Thr Val Glu Phe Ser Gly Tyr Gly Thr Leu Gly Leu Glu Cys His 
    50                  55                  60                  


Val Gln Ser Ala Ile Asp Phe Thr Thr His Tyr Leu Val Val Ile Gly 
65                  70                  75                  80  


Ser Asp Ala Trp Leu Val His Lys Gln Trp Val Ala Asp Val Thr Leu 
                85                  90                  95      


Pro Trp Ser His Gly Asp Ala Asn Val Trp Arg Asp Lys Asn Tyr Leu 
            100                 105                 110         


Val Glu Phe Gly Glu Pro His Ala Ala Thr Val Lys Val Leu Ala Met 
        115                 120                 125             


Gly Pro Gln Glu Gly Ala Leu Arg Thr Ala Leu Ala Gly Ala Met Val 
    130                 135                 140                 


Val Ser Tyr Asp Ser Gly Ser Lys Thr Phe Lys Leu His Gly Gly His 
145                 150                 155                 160 


Val Thr Cys Lys Ala Met Val Asn Asn Leu Val Leu Lys Gly Thr Thr 
                165                 170                 175     


Tyr Gln Asn Cys Arg Gly Gly Leu Ser Phe Thr Lys Thr Pro Ala Asp 
            180                 185                 190         


Thr Gly His Gly Thr Val Val Met Gln Val Lys Val Thr Lys Asn Thr 
        195                 200                 205             


Pro Cys Arg Leu Thr Ala Ile Ala Ser Asp Asp Ala Ser Gly Arg Val 
    210                 215                 220                 


Asn Arg Gly Thr Leu Val Thr Ser Asn Pro Val Ala Asn Ser Ala Asn 
225                 230                 235                 240 


Asp Glu Val Leu Ile Glu Ile Asn Pro Pro Tyr Gly Glu Ser Tyr Leu 
                245                 250                 255     


Ile Ala Gly Val Gly Asp Asp Lys Leu Val Tyr Gln Trp Phe Gln 
            260                 265                 270     


<210>  225
<211>  1692
<212>  DNA
<213>  ArtSeq 	pGP80

<400>  225
atggagagga tcgtgctgct gctggccatc gtgagcctgg tgaagagcga ccagatctgc       60

atcggctacc acgccaacaa gagcaccaag caggtggaca ccatcatgga gaagaacgtg      120

accgtgaccc acgcccagga catcctggag aggacccaca acggcaagct gtgcagcctg      180

aacggcgtga agcccctgat cctgagggac tgcagcgtgg ccggctggct gctgggcaac      240

cccatgtgcg acgagttcct gaacgtgccc gagtggagct acatcgtgga gaaggacaac      300

cccatcaaca gcctgtgcta ccccggcgac ttcaacgact acgaggagct gaagcacctg      360

ctgagcagca ccaaccactt cgagaagatc cagatcatcc ccaggagcag ctggagcaac      420

cacgacgcca gcagcggcgt gagcagcgcc tgcccctaca tcggcaggag cagcttcttc      480

aggaacgtgg tgtggctgat caagaaggac aacgcctacc ccaccatcaa gaggagctac      540

aacaacacca accaggagga cctgctgatc ctgtggggca tccaccaccc caacgacgcc      600

gccgagcaga ccaagctgta ccagaacccc accacctacg tgagcgtggg caccagcacc      660

ctgaaccaga ggagcatccc cgagatcgcc accaggccca aggtgaacgg ccagagcggc      720

aggatggagt tcttctggac catcctgaag cccaacgacg ccatcaactt cgagagcaac      780

ggcaacttca tcgcccccga gtacgcctac aagatcgtga agaagggcga cagcgccatc      840

atgaagagcg gcctggccta cggcaactgc gacaccaagt gccagacccc cgtgggcgcc      900

atcaacagca gcatgccctt ccacaacatc cacccccaca ccatcggcga gtgccccaag      960

tacgtgaaga gcgacaggct ggtgctggcc accggcctga ggaacgtgcc ccagaggaag     1020

aagaggggcc tgttcggcgc catcgccggc ttcatcgagg gcggctggca gggcatggtg     1080

gacggctggt acggctacca ccacagcaac gagcagggca gcggctacgc cgccgacaag     1140

gagagcaccc agaaggccat cgacggcatc accaacaagg tgaacagcat catcgacaag     1200

atgaacaccc agttcaaggc cgtgggcaag gagttcaaca acctggagag gagggtggag     1260

aacctgaaca agaagatgga ggacggcttc ctggacgtgt ggacctacaa cgtggagctg     1320

ctggtgctga tggagaacga gaggaccctg gacttccacg acagcaacgt gaagaacctg     1380

tacgacaagg tgaggctgca gctgaaggac aacgccaggg agctgggcaa cggctgcttc     1440

gagttctacc acaagtgcga caacgagtgc atggagagcg tgaggaacgg cacctacgac     1500

tacccccagt acagcgagga ggccaggctg aacagggagg agatcagcgg cgtgaagctg     1560

gagagcatgg gcgtgtacca gatcctgagc atctacagca ccgtggccag cagcctggcc     1620

ctggccatca tgatcgccgg cctgagcttc tggatgtgca gcaacggcag cctgcagtgc     1680

aggatctgca tc                                                         1692


<210>  226
<211>  1680
<212>  DNA
<213>  ArtSeq 	pGP81

<400>  226
atgaacaccc agatcctggt gttcgccctg atcgccatca tccccaccaa cgccgacaag       60

atctgcctgg gccaccacgc cgtgagcaac ggcaccaagg tgaacaccct gaccgagagg      120

ggcgtggagg tggtgaacgc caccgagacc gtggagagga ccaacatccc caggatctgc      180

agcaagggca agaggaccgt ggacctgggc cagtgcggcc tgctgggcac catcaccggc      240

cccccccagt gcgaccagtt cctggagttc agcgccgacc tgatcatcga gaggagggag      300

ggcagcgacg tgtgctaccc cggcaagttc gtgaacgagg aggccctgag gcagatcctg      360

agggagagcg gcggcatcga caaggaggcc atgggcttca cctacagcgg catcaggacc      420

aacggcgcca ccagcgcctg caggaggagc ggcagcagct tctacgccga gatgaagtgg      480

ctgctgagca acaccgacaa cgccgccttc ccccagatga ccaagagcta caagaacacc      540

aggaagagcc ccgccctgat cgtgtggggc atccaccaca gcgtgagcac cgccgagcag      600

accaagctgt acggcagcgg caacaagctg gtgaccgtgg gcagcagcaa ctaccagcag      660

agcttcgtgc ccagccccgg cgccaggccc caggtgaacg gcatcagcgg caggatcgac      720

ttccactggc tgatgctgaa ccccaacgac accgtgacct tcagcttcaa cggcgccttc      780

atcgcccccg acagggccag cttcctgagg ggcaagagca tgggcatcca gagcggcgtg      840

caggtggacg ccaactgcga gggcgactgc taccacagcg gcggcaccat catcagcaac      900

ctgcccttcc agaacatcga cagcagggcc gtgggcaagt gccccaggta cgtgaagcag      960

aggagcctgc tgctggccac cggcatgaag aacgtgcccg agatccccaa gggcaggggc     1020

ctgttcggcg ccatcgccgg cttcatcgag aacggctggg agggcctgat cgacggctgg     1080

tacggcttca ggcaccagaa cgcccagggc gagggcaccg ccgccgacta caagagcacc     1140

cagagcgcca tcgaccagat caccggcaag ctgaacaggc tgatcgagaa gaccaaccag     1200

cagttcgagc tgatcgacaa cgagttcaac gaggtggaga agcagatcgg caacgtgatc     1260

aactggacca gggacagcat caccgaggtg tggagctaca acgccgagct gctggtggcc     1320

atggagaacc agcacaccat cgacctggcc gacagcgaga tggacaagct gtacgagagg     1380

gtgaagaggc agctgaggga gaacgccgag gaggacggca ccggctgctt cgagatcttc     1440

cacaagtgcg acgacgactg catggccagc atcaggaaca acacctacga ccacagcaag     1500

tacagggagg aggccatgca gaacaggatc cagatcgacc ccgtgaagct gagcagcggc     1560

tacaaggacg tgatcctgtg gttcagcttc ggcgccagct gcttcatcct gctggccatc     1620

gtgatgggcc tggtgttcat ctgcgtgaag aacggcaaca tgaggtgcac catctgcatc     1680


<210>  227
<211>  2949
<212>  DNA
<213>  ArtSeq 	pGP65

<400>  227
atgtcgctcg ccactgtcat gtgcgtcctg gccaatatca cgtttccatg tgatcaacca       60

ccctgcatgc catgctgtta tgaaaagaat ccacacgaaa cactcaccat gctggaacag      120

aattacgaca gccgagccta tgatcagctg ctcgatgccg ctgtgaaatg taatgctagg      180

agaaccagga gagatttgga cactcatttc acccagtata agttggcacg cccgtatatt      240

gctgattgcc ctaactgtgg gcatagtcgg tgcgacagcc ctatagctat agaagaagtc      300

agaggggatg cgcatgcagg agtcatccgc atccagacat cagctatgtt tggtctgaag      360

acggatggag tcgatttggc ctacatgagt ttcatgaacg gcaaaacgca gaaatcaata      420

aagatcgaca acctgcatgt gcgcacctca gccccttgtt ccctcgtgtc gcaccacggc      480

tattacatct tggctcaatg cccaccaggg gacacggtta cagttgggtt tcacgacggg      540

cctaaccgcc atacgtgcac agttgcccat aaggtagaat tcaggccagt gggtagagag      600

aaataccgtc acccacctga acatggagtt gaattaccgt gtaaccgtta cactcacaag      660

cgtgcagacc aaggacacta tgttgagatg catcaaccag ggctagttgc cgaccactct      720

ctccttagca tccacagtgc caaggtgaaa attacggtac cgagcggcgc ccaagtgaaa      780

tactactgca agtgtccaga tgtacgagag ggaattacca gcagcgacca tacaaccacc      840

tgcacggatg tcaaacaatg cagggcttac ctgattgaca acaagaaatg ggtgtacaac      900

tctggaagac tgcctcgagg agagggcgac acttttaaag gaaaacttca tgtgcccttt      960

gtgcctgtta aggccaagtg catcgccacg ctggcaccgg agcctctagt tgagcacaaa     1020

caccgcaccc tgattttaca cctgcacccg gaccacccga ccttgctgac gaccaggtca     1080

cttggaagtg atgcaaatcc aactcgacaa tggattgagc gaccaacaac tgtcaatttc     1140

acagtcaccg gagaagggtt ggagtatacc tggggaaacc atccaccaaa aagagtatgg     1200

gctcaagagt caggagaagg gaacccacat ggatggccgc acgaagtggt agtctattac     1260

tacaacagat acccgctaac cacaattatc gggttatgca cctgtgtggc tatcatcatg     1320

gtctcttgtg tcacatccgt gtggctcctt tgcaggactc gcaatctttg cataaccccg     1380

tataaactag ccccgaacgc tcaagtccca atactcctgg cgttactttg ctgcattaag     1440

ccgacgaggg cagacgacac cttgcaagtg ctgaattatc tgtggaacaa caatcaaaac     1500

tttttctgga tgcagacgct tatcccactt gcagcgctta tcgtatgcat gcgcatgctg     1560

cgttgcttat tttgctgtgg gccggctttt ttacttgtct gcggcgcctt gggcgccgca     1620

gcgtacgaac acacagcagt gatgccgaac aaggtgggga tcccgtataa agctttagtc     1680

gaacgcccag ggtatgcacc cgttcaccta cagatacagc tggttaatac caggataatt     1740

ccatcaacta acctggagta catcacctgc aagtacaaga caaaagtgcc gtctccagta     1800

gtgaaatgct gcggtgccac tcaatgtacc tctaaacccc atcctgacta tcagtgtcag     1860

gtgtttacag gtgtttaccc attcatgtgg ggaggagcct actgcttctg cgacaccgaa     1920

aacacccaga tgagcgaggc gtatgtagag cgctcggaag agtgctctat cgaccacgca     1980

aaagcttata aagtacacac aggcactgtt caggcaatgg tgaacataac ttatgggagc     2040

gtcagctgga gatctgcaga tgtctacgtc aatggtgaaa ctcccgcgaa aataggagat     2100

gccaaactca tcataggtcc actgtcatct gcgtggtccc cattcgataa caaggtggtg     2160

gtttatgggc atgaagtgta taattacgac tttcctgagt acagcaccgg caaagcaggc     2220

tctttcggag acctgcaatc acgcacatca accagcaacg atctgtacgc aaataccaac     2280

ttgaagctac aacgacccca ggctggtatc gtgcacacac ctttcaccca ggcgccctct     2340

ggcttcgaac gatggaaaag ggacaaaggg gcaccgttga acgacgtagc cccgtttggc     2400

tgttcaattg ccctggagcc gctccgtgca gaaaattgtg cagtgggaag catccctata     2460

tctatagata tacccgatgc ggctttcacc agaatatctg aaacaccgac agtctcagac     2520

ctggaatgca aaattacgga gtgtacttat gcctccgatt tcggtggtat agccaccgtt     2580

gcctacaaat ccagtaaagc aggaaactgt ccaattcatt ctccatcggg tgttgcagtt     2640

attaaagaga atgacgtcac ccttgctgag agcggatcat ttacattcca cttctccact     2700

gcaaacatcc atcctgcttt taagctgcag gtctgcacca gtgcagttac ctgcaaagga     2760

gattgcaagc caccgaaaga tcatatcgtc gattatccag cacaacatac cgaatccttt     2820

acgtcggcga tatccgccac cgcgtggtcg tggctaaaag tgctggtagg aggaacatca     2880

gcatttattg ttctggggct tattgctaca gcagtggttg ccctagttct gttcttccat     2940

agacattaa                                                             2949


<210>  228
<211>  2946
<212>  DNA
<213>  ArtSeq 	pGP66

<400>  228
atgtcactag tgaccactat gtgcctgctc gccaatgtga cgttcccatg tgccgaacca       60

ccaatttgct acgacagaaa accagcagag actttggcca tgctcagcgt taacgttgac      120

aacccgggct acgatgagct actggaagca gctgttaagt gccccggaag aaaaaggaga      180

tctaccaagg agctgtttaa ggagtataag ctaacgcgcc cttacatggc cagatgcatc      240

agatgtgccg ttgggagctg ccatagtcca atagcaattg aggcagtgaa gagcgacggg      300

cacgacggct atgttagact tcagacttcc tcgcagtatg gcctggattc ctctggcaac      360

ttaaagggaa ggactatgcg gtatgatatg cacgggacca ttgaagagat accactacat      420

caagtgtcac tccacacatc tcgcccgtgt cacattgtgg atgggcatgg ttattttctg      480

cttgctaggt gcccggcagg ggactccatc accatggaat ttaagaaagg ttcagtcaca      540

cactcctgct cagtgccgta tgaagtgaaa tttaatcctg taggcagaga actctacact      600

catccaccag aacacggagc agagcaagcg tgccaagtct acgcgcacga tgcacagaac      660

agaggagctt atgtcgagat gcacctcccg ggctcagaag tggacagcag tttgatttcc      720

ttgagcggca gttcagtcac cgtgacacct cctgtcggga ctagcgcctt ggtggaatgc      780

aagtgcggcg gcacaaagat ctccgaaacc atcaacaagg caaaacagtt cagccagtgc      840

acaaagaagg agcagtgcag agcatatcga ctgcagaatg acaagtgggt gtataattct      900

gacaaactgc ccaaagcagc gggagccacc ctaaaaggaa aactacacgt cccgttcttg      960

ctggcagacg gcaaatgcac cgtgcctcta gcaccggaac ctatgataac cttcggtttc     1020

cgatcagtgt cactgaaact gcaccctaag aatcccacat atctgaccac tcgccaactt     1080

gctgatgagc ctcattacac gcacgagctc atatctgaac cagctgttag gaattttacc     1140

gtcactgaaa aggggtggga gtttgtatgg ggaaaccatc cgccgaaaag gttttgggca     1200

caggaaacag cacccggaaa tccacatggg ctgccacatg aggtgataac tcattattac     1260

cacagatacc ctatgtccac catcctgggt ttgtcaattt gcgccgccat tgtaaccgtt     1320

tccgttgcag cgtccacctg gctgttttgc aaatccagag tttcgtgcct aactccttac     1380

cggctaacac ctaacgccag gatgccgctt tgcctggccg tgctttgctg cgcccgcact     1440

gcccgggccg agaccacctg ggagtccttg gatcacctat ggaacaataa ccaacagatg     1500

ttctggattc aattgctgat ccctctggcc gccttgattg tagtgactcg cctgctcaag     1560

tgcgtgtgct gtgtagtgcc ttttttagtc gtggccggcg ccgcaggcgc cggcgcctac     1620

gagcacgcga ccacgatgcc gagccaagcg ggaatctcgt ataacaccat agtcaacaga     1680

gcaggctacg cgccactccc tatcagcata acaccaacaa agatcaagct gatacccaca     1740

gtgaacttgg agtacgtcac ctgccactac aaaacaggaa tggattcacc agccatcaaa     1800

tgctgcggat ctcaggaatg tactccaact aacaggcctg atgaacagtg caaagtcttc     1860

acaggggttt acccgttcat gtggggaggt gcatattgct tttgcgacac tgagaatact     1920

caggtcagca aggcctacgt aatgaaatct gacgactgcc ttgcggatca tgctgaagca     1980

tacaaagcgc acacagcctc agtgcaggcg ttcctcaaca tcacagtggg ggaacactct     2040

attgtgacca ccgtgtatgt gaatggagaa actcctgtga acttcaatgg ggtcaaacta     2100

actgcaggtc cactttccac agcttggaca ccctttgaca gaaaaatcgt gcagtatgcc     2160

ggggagatct ataattacga ttttcctgag tatggggcag gacaaccagg agcatttgga     2220

gacatacaat ccagaacagt ctcaagctca gatctgtatg ccaataccaa cctagtgctg     2280

cagagaccca aagcaggagc gatccatgtg ccatacactc aggcaccatc gggttttgag     2340

caatggaaga aagataaagc tccgtcattg aaattcaccg cccctttcgg atgcgaaata     2400

tatacaaacc ccattcgcgc cgaaaattgt gctgtagggt caattccatt agcctttgac     2460

attcccgacg ccttgttcac cagggtgtca gaaacaccga cactttcagc ggccgaatgc     2520

actcttaacg agtgcgtgta ttcatccgac tttggcggga tcgccacggt caagtattcg     2580

gccagcaagt caggcaagtg cgcagtccat gtgccatcag ggactgctac cctaaaagaa     2640

gcagcagtcg agctaaccga gcaagggtcg gcgaccattc atttctcgac cgcaaatatc     2700

cacccggagt tcaggctcca aatatgcaca tcatatgtca cgtgcaaagg tgattgtcac     2760

cccccgaaag accacattgt gacacacccc cagtatcacg cccaaacatt tacagccgcg     2820

gtgtcaaaaa ccgcgtggac gtggttaaca tccctgctgg gaggatcggc cgtaattatt     2880

ataattggct tagtgctggc tactattgtg gccatgtacg tgctgaccaa ccagaaacat     2940

aattga                                                                2946


<210>  229
<211>  2937
<212>  DNA
<213>  ArtSeq 	pGP67

<400>  229
atgtcactag ttacagcact gtgcgtgctt tcgaatgtta cgttcccatg cgataaacca       60

cccgtgtgct attcactggc gccagaacga acactcgacg tgctcgagga gaacgtcaac      120

aatccaaatt acgacacgct gctggagaac gtcttgaaat gtccgtcacg ccggcccaaa      180

cgaagcatta ccgatgactt cacactgacc agtccctacc tagggttctg cccgtattgc      240

agacactcag cgccgtgttt cagcccaata aaaattgaga acgtgtggga cgaatctgat      300

gatggatcga ttagaatcca ggtctcggca caattcggct atgatcaggc aggcactgca      360

gatgtcacca aattccgtta catgtcttac gaccacgacc atgacatcaa ggaagacagt      420

gtgaagaaaa tagctattag tacatctgga ccctgccgtc gtcttggcca caaagggtac      480

ttcctgttag ctcaatgtcc tccaggtgac agtgtaaccg tcagtatcac gagcggagca      540

tctgagaatt catgcaccgt ggagaaaaag atcaggagga agtttgtcgg tagagaggag      600

tacttgttcc cacctgtcca tggaaagctg gtaaagtgcc acgtttacga tcacttgaag      660

gagacgtctg ccggatacat aaccatgcac aggccaggcc cacacgcgta taagtcctat      720

ctggaggaag cgtcaggcga agtgtacatt aaaccacctt ctggcaagaa cgtcacctac      780

gaatgtaagt gtggcgacta cagcacaggt attgtgagca cgcgaacgaa gatgaacggc      840

tgcaccaaag caaaacagtg cattgcctac aagagcgacc aaacgaaatg ggtctacaac      900

tcgccggatc ttattaggca cacagaccac tcagtgcaag gtaaactgca cattccattc      960

cgcttgacac cgacattctg cccggttccg ttagctcaca cgcctacagt cacgaagtgg     1020

tttaaaggca tcaccctcca cctgactgca acgcgaccaa cattgctgac aacgagaaaa     1080

ttggggctgc gagcagacgc aacagcagaa tggattacag ggactacatc caggaatttt     1140

tctgtggggc gagaagggct ggagtacgta tggggcaacc atgaaccagt cagagtctgg     1200

gcccaggagt cggcaccagg cgacccgcat ggatggccgc atgagatcat catccactat     1260

tatcatcggc atccagtcta cactgtcatt gtgctgtgcg gtgtcgctct tgctatcctg     1320

gtaggcattg catcgtcagc agcttgtatc gccaaagcaa gaagagactg cctgacgcca     1380

tacgcgcttg caccgaacgc aacggtaccc acagcattag cagttttgtg ctgtattcgg     1440

ccaaccaacg cagaaacatt tggagaaact ttgaatcatc tgtggtttaa caaccaaccg     1500

tttctctggg cacagttgtg catccctctg gcagcgctta ttattctgtt tcgctgcttt     1560

tcatgctgca tgcctttttt attggttgca ggcgtctgcc tggggaaggt agacgccttc     1620

gaacatgcga ccactgtgcc aaatgttccg gggatcccgt ataaggcgtt ggtcgaacgt     1680

gcaggttacg cgccacttaa tctggagatt acggtcgtct catcggaatt aacaccctca     1740

actaacaagg agtatgtgac ctgcaaattc cacacagtca ttccttcacc gcaagttaaa     1800

tgctgcgggt ccctcgagtg taaggcatcc tcaaaagcgg attacacatg ccgcgttttt     1860

ggcggtgtgt accctttcat gtggggaggc gcacagtgct tctgtgacag tgagaacaca     1920

caactgagtg aggcatacgt cgagttcgct ccagactgca ctatagatca tgcagtcgca     1980

ctaaaagttc acacagctgc tctgaaagtc ggcctgcgta tagtatacgg caataccacc     2040

gcgcacctgg atacgttcgt caatggcgtc acgccaggtt cctcacggga cctgaaggtc     2100

atagcagggc cgatatcagc cgctttttca ccctttgacc ataaggtcgt catcagaaag     2160

gggcttgttt ataactacga cttccctgag tatggagcta tgaaaccagg agcgttcggc     2220

gatattcaag catcctcgct tgatgccaca gacatagtag cccgcactga catacggctg     2280

ctgaagcctt ctgtcaagaa catccacgtc ccctacaccc aagcagtatc agggtatgaa     2340

atgtggaaga acaactcagg acgacccctg caagaaacag caccatttgg atgtaaaatt     2400

gaagtggagc ctctgcgagc gtctaattgt gcttatgggc acatccctat ctcgattgac     2460

atccctgatg cagcttttgt gagatcatca gaatcaccaa caattttaga agtcagctgc     2520

acagtagcag actgcattta ttctgcagac tttggtggtt cgctaacact acagtacaaa     2580

gctgacaggg agggacattg tccagttcac tcccactcca ctacagctgt tttgaaggaa     2640

gcgaccacac atgtgactgc cacaggcagc ataacactac attttagcac atcgagccca     2700

caagcaaatt tcatagtttc gctatgcggc aagaagacca cttgcaatgc tgaatgtaaa     2760

ccaccggccg accacataat tggagaacca cataaggtcg accaagaatt ccaggcggca     2820

gtttccaaaa catcttggaa ctggctgctt gcactgtttg ggggagcatc atccctcatt     2880

gctgtaggac ttatagtgtt ggtctgcagc tctatgctta taaacacacg tagatga        2937


<210>  230
<211>  2964
<212>  DNA
<213>  ArtSeq 	pGP68

<400>  230
atgtccgccc cgctgattac tgccatgtgt gtccttgcca atgctacctt cccgtgcttc       60

cagcccccgt gtgtaccttg ctgctatgaa aacaacgcag aggccacact acggatgctc      120

gaggataacg tggataggcc agggtactac gacctccttc aggcagcctt gacgtgccga      180

aacggaacaa gacaccggcg cagcgtgtcg caacacttca acgtgtataa ggctacacgc      240

ccttacatcg cgtactgcgc cgactgcgga gcagggcact cgtgtcatag ccccgtagca      300

attgaagcgg tcaggtccga agctaccgac gggatgctga agattcagtt ctcggcacaa      360

attggcatag ataagagtga caatcatgac tacacgaaga taaggtacgc agacgggcac      420

gccattgaga atgccgtccg gtcatctttg aaggtagcca cctccggaga ctgtttcgtc      480

catggcacaa tgggacattt catactggca aagtgcccac cgggtgaatt cctgcaggtc      540

tcgatccagg acaccagaaa cgcggtccgt gcctgcagaa tacaatatca tcatgaccct      600

caaccggtgg gtagagaaaa atttacaatt agaccacact atggaaaaga gatcccttgc      660

accacttatc aacagaccac agcggagacc gtggaggaaa tcgacatgca tatgccgcca      720

gatacgccgg acaggacgtt gctatcacag caatctggca atgtaaagat cacagtcgga      780

ggaaagaagg tgaaatacaa ctgcacctgt ggaaccggaa acgttggcac tactaattcg      840

gacatgacga tcaacacgtg tctaatagag cagtgccacg tctcagtgac ggaccataag      900

aaatggcagt tcaactcacc tttcgtcccg agagccgacg aaccggctag aaaaggcaaa      960

gtccatatcc cattcccgtt ggacaacatc acatgcagag ttccaatggc gcgcgaacca     1020

accgtcatcc acggcaaaag agaagtgaca ctgcaccttc acccagatca tcccacgctc     1080

ttttcctacc gcacactggg tgaggacccg cagtatcacg aggaatgggt gacagcggcg     1140

gtggaacgga ccatacccgt accagtggac gggatggagt accactgggg aaacaacgac     1200

ccagtgaggc tttggtctca actcaccact gaagggaaac cgcacggctg gccgcatcag     1260

atcgtacagt actactatgg gctttacccg gccgctacag tatccgcggt cgtcgggatg     1320

agcttactgg cgttgatatc gatcttcgcg tcgtgctaca tgctggttgc ggcccgcagt     1380

aagtgcttga ccccttatgc tttaacacca ggagctgcag ttccgtggac gctggggata     1440

ctctgctgcg ccccgcgggc gcacgcagct agtgtggcag agactatggc ctacttgtgg     1500

gaccaaaacc aagcgttgtt ctggttggag tttgcggccc ctgttgcctg catcctcatc     1560

atcacgtatt gcctcagaaa cgtgctgtgt tgctgtaaga gcctttcttt tttagtgcta     1620

ctgagcctcg gggcaaccgc cagagcttac gaacattcga cagtaatgcc gaacgtggtg     1680

gggttcccgt ataaggctca cattgaaagg ccaggatata gccccctcac tttgcagatg     1740

caggttgttg aaaccagcct cgaaccaacc cttaatttgg aatacataac ctgtgagtac     1800

aagacggtcg tcccgtcgcc gtacgtgaag tgctgcggcg cctcagagtg ctccactaaa     1860

gagaagcctg actaccaatg caaggtttac acaggcgtgt acccgttcat gtggggaggg     1920

gcatattgct tctgcgactc agaaaacacg caactcagcg aggcgtacgt cgatcgatcg     1980

gacgtatgca ggcatgatca cgcatctgct tacaaagccc atacagcatc gctgaaggcc     2040

aaagtgaggg ttatgtacgg caacgtaaac cagactgtgg atgtttacgt gaacggagac     2100

catgccgtca cgataggggg tactcagttc atattcgggc cgctgtcatc ggcctggacc     2160

ccgttcgaca acaagatagt cgtgtacaaa gacgaagtgt tcaatcagga cttcccgccg     2220

tacggatctg ggcaaccagg gcgcttcggc gacatccaaa gcagaacagt ggagagtaac     2280

gacctgtacg cgaacacggc actgaagctg gcacgccctt cacccggcat ggtccatgta     2340

ccgtacacac agacaccttc agggttcaaa tattggctaa aggaaaaagg gacagcccta     2400

aatacgaagg ctccttttgg ctgccaaatc aaaacgaacc ctgtcagggc catgaactgc     2460

gccgtgggaa acatccctgt ctccatgaat ttgcctgaca gcgcctttac ccgcattgtc     2520

gaggcgccga ccatcattga cctgacttgc acagtggcta cctgtacgca ctcctcggat     2580

ttcggcggcg tcttgacact gacgtacaag accaacaaga acggggactg ctctgtacac     2640

tcgcactcta acgtagctac tctacaggag gccacagcaa aagtgaagac agcaggtaag     2700

gtgaccttac acttctccac ggcaagcgca tcaccttctt ttgtggtgtc gctatgcagt     2760

gctagggcca cctgttcagc gtcgtgtgag cccccgaaag accacatagt cccatatgcg     2820

gctagccaca gtaacgtagt gtttccagac atgtcgggca ccgcactatc atgggtgcag     2880

aaaatctcgg gtggtctggg ggccttcgca atcggcgcta tcctggtgct ggttgtggtc     2940

acttgcattg ggctccgcag ataa                                            2964


<210>  231
<211>  2949
<212>  DNA
<213>  ArtSeq 	pGP69

<400>  231
atgtccgcag caccactggt cacggcaatg tgtttgctcg gaaatgtgag cttcccatgc       60

gaccgcccgc ccacatgcta tacccgcgaa ccttccagag ccctcgacat ccttgaagag      120

aacgtgaacc atgaggccta cgataccctg ctcaatgcca tattgcggtg cggatcgtct      180

ggcagaagca aaagaagcgt cattgacgac tttaccctga ccagccccta cttgggcaca      240

tgctcgtact gccaccatac tgtaccgtgc ttcagccctg ttaagatcga gcaggtctgg      300

gacgaagcgg acgataacac catacgcata cagacttccg cccagtttgg atacgaccaa      360

agcggagcag caagcgcaaa caagtaccgc tacatgtcgc ttaagcagga tcacaccgtt      420

aaagaaggca ccatggatga catcaagatt agcacctcag gaccgtgtag aaggcttagc      480

tacaaaggat actttctcct cgcaaaatgc cctccagggg acagcgtaac ggttagcata      540

gtgagtagca actcagcaac gtcatgtaca ctggcccgca agataaaacc aaaattcgtg      600

ggacgggaaa aatatgatct acctcccgtt cacggtaaaa aaattccttg cacagtgtac      660

gaccgtctga aagaaacaac tgcaggctac atcactatgc acaggccgag accgcacgct      720

tatacatcct acctggaaga atcatcaggg aaagtttacg caaagccgcc atctgggaag      780

aacattacgt atgagtgcaa gtgcggcgac tacaagaccg gaaccgtttc gacccgcacc      840

gaaatcactg gttgcaccgc catcaagcag tgcgtcgcct ataagagcga ccaaacgaag      900

tgggtcttca actcaccgga cttgatcaga catgacgacc acacggccca agggaaattg      960

catttgcctt tcaagttgat cccgagtacc tgcatggtcc ctgttgccca cgcgccgaat     1020

gtaatacatg gctttaaaca catcagcctc caattagata cagaccactt gacattgctc     1080

accaccagga gactaggggc aaacccggaa ccaaccactg aatggatcgt cggaaagacg     1140

gtcagaaact tcaccgtcga ccgagatggc ctggaataca tatggggaaa tcatgagcca     1200

gtgagggtct atgcccaaga gtcagcacca ggagaccctc acggatggcc acacgaaata     1260

gtacagcatt actaccatcg ccatcctgtg tacaccatct tagccgtcgc atcagctacc     1320

gtggcgatga tgattggcgt aactgttgca gtgttatgtg cctgtaaagc gcgccgtgag     1380

tgcctgacgc catacgccct ggccccaaac gccgtaatcc caacttcgct ggcactcttg     1440

tgctgcgtta ggtcggccaa tgctgaaacg ttcaccgaga ccatgagtta cttgtggtcg     1500

aacagtcagc cgttcttctg ggtccagttg tgcatacctt tggccgcttt catcgttcta     1560

atgcgctgct gctcctgctg cctgcctttt ttagtggttg ccggcgccta cctggcgaag     1620

gtagacgcct acgaacatgc gaccactgtt ccaaatgtgc cacagatacc gtataaggca     1680

cttgttgaaa gggcagggta tgccccgctc aatttggaga tcactgtcat gtcctcggag     1740

gttttgcctt ccaccaacca agagtacatt acctgcaaat tcaccactgt ggtcccctcc     1800

ccaaaaatca aatgctgcgg ctccttggaa tgtcagccgg ccgctcatgc agactatacc     1860

tgcaaggtct tcggaggggt ctaccccttt atgtggggag gagcgcaatg tttttgcgac     1920

agtgagaaca gccagatgag tgaggcgtac gtcgaattgt cagcagattg cgcgtctgac     1980

cacgcgcagg cgattaaggt gcacactgcc gcgatgaaag taggactgcg tattgtgtac     2040

gggaacacta ccagtttcct agatgtgtac gtgaacggag tcacaccagg aacgtctaaa     2100

gacttgaaag tcatagctgg accaatttca gcatcgttta cgccattcga tcataaggtc     2160

gttatccatc gcggcctggt gtacaactat gacttcccgg aatatggagc gatgaaacca     2220

ggagcgtttg gagacattca agctacctcc ttgactagca aggatctcat cgccagcaca     2280

gacattaggc tactcaagcc ttccgccaag aacgtgcatg tcccgtacac gcaggcctca     2340

tcaggatttg agatgtggaa aaacaactca ggccgcccac tgcaggaaac cgcacctttc     2400

gggtgtaaga ttgcagtaaa tccgctccga gcggtggact gttcatacgg gaacattccc     2460

atttctattg acatcccgaa cgctgccttt atcaggacat cagatgcacc actggtctca     2520

acagtcaaat gtgaagtcag tgagtgcact tattcagcag acttcggcgg gatggccacc     2580

ctgcagtatg tatccgaccg cgaaggtcaa tgccccgtac attcgcattc gagcacagca     2640

actctccaag agtcgacagt acatgtcctg gagaaaggag cggtgacagt acactttagc     2700

accgcgagtc cacaggcgaa ctttatcgta tcgctgtgtg ggaagaagac aacatgcaat     2760

gcagaatgta aaccaccagc tgaccatatc gtgagcaccc cgcacaaaaa tgaccaagaa     2820

tttcaagccg ccatctcaaa aacatcatgg agttggctgt ttgccctttt cggcggcgcc     2880

tcgtcgctat taattatagg acttatgatt tttgcttgca gcatgatgct gactagcaca     2940

cgaagatga                                                             2949


<210>  232
<211>  2946
<212>  DNA
<213>  ArtSeq 	pGP70

<400>  232
atgtgcctgt tggcaaacac cacgttcccc tgctcccagc ccccttgcac gccctgctgc       60

tacgaaaagg aaccggagga aaccctacgc atgcttgagg acaacgtcat gagacctggg      120

tactatcagc tgctacaagc atccttaaca tgttctcccc accgccagcg acgcagcacc      180

aaggacaact tcaatgtcta taaagccaca agaccatact tagctcactg tcccgactgt      240

ggagaagggc actcgtgcca tagtcccgta gcactagaac gcatcagaaa tgaagcgaca      300

gacgggacgc tgaaaatcca ggtctccttg caaatcggaa taaagacgga tgacagccac      360

gattggacca agctgcgtta tatggacaac cacatgccag cagacgcaga gagggcgggg      420

ctatttgtaa gaacatcagc accgtgtacg attactggga caatgggaca cttcatcctg      480

gcccgatgtc caaaagggga aactctgacg gtgggattca ctgacagtag gaagattagt      540

cactcatgta cgcacccatt tcaccacgac cctcctgtga taggtcggga aaaattccat      600

tcccgaccgc agcacggtaa agagctacct tgcagcacgt acgtgcagag caccgccgca      660

actaccgagg agatagaggt acacatgccc ccagacaccc ctgatcgcac attaatgtca      720

caacagtccg gcaacgtaaa gatcacagtc aatggccaga cggtgcggta caagtgtaat      780

tgcggtggct caaatgaagg actaacaact acagacaaag tgattaataa ctgcaaggtt      840

gatcaatgtc atgccgcggt caccaatcac aaaaagtggc agtataactc ccctctggtc      900

ccgcgtaatg ctgaacttgg ggaccgaaaa ggaaaaattc acatcccgtt tccgctggca      960

aatgtaacat gcagggtgcc taaagcaagg aaccccaccg tgacgtacgg gaaaaaccaa     1020

gtcatcatgc tactgtatcc tgaccaccca acactcctgt cctaccggaa tatgggagaa     1080

gaaccaaact atcaagaaga gtgggtgatg cataagaagg aagtcgtgct aaccgtgccg     1140

actgaagggc tcgaggtcac gtggggcaac aacgagccgt ataagtattg gccgcagtta     1200

tctacaaacg gtacagccca tggccacccg catgagataa ttctgtatta ttatgagctg     1260

taccccacta tgactgtagt agttgtgtca gtggccacgt tcatactcct gtcgatggtg     1320

ggtatggcag cggggatgtg catgtgtgca cgacgcagat gcatcacacc gtatgaactg     1380

acaccaggag ctaccgtccc tttcctgctt agcctaatat gctgcatcag aacagctaaa     1440

gcggccacat accaagaggc tgcgatatac ctgtggaacg agcagcaacc tttgttttgg     1500

ctacaagccc ttattccgct ggcagccctg attgttctat gcaactgtct gagactctta     1560

ccatgctgct gtaaaacgtt ggctttttta gccgtaatga gcgtcggtgc ccacactgtg     1620

agcgcgtacg aacacgtaac agtgatcccg aacacggtgg gagtaccgta taagactcta     1680

gtcaatagac ctggctacag ccccatggta ttggagatgg aactactgtc agtcactttg     1740

gagccaacac tatcgcttga ttacatcacg tgcgagtaca aaaccgtcat cccgtctccg     1800

tacgtgaagt gctgcggtac agcagagtgc aaggacaaaa acctacctga ctacagctgt     1860

aaggtcttca ccggcgtcta cccatttatg tggggcggcg cctactgctt ctgcgacgct     1920

gaaaacacgc agttgagcga agcacacgtg gagaagtccg aatcatgcaa aacagaattt     1980

gcatcagcat acagggctca taccgcatct gcatcagcta agctccgcgt cctttaccaa     2040

ggaaataaca tcactgtaac tgcctatgca aacggcgacc atgccgtcac agttaaggac     2100

gccaaattca ttgtggggcc aatgtcttca gcctggacac ctttcgacaa caaaattgtg     2160

gtgtacaaag gtgacgtcta taacatggac tacccgccct ttggcgcagg aagaccagga     2220

caatttggcg atatccaaag tcgcacacct gagagtaaag acgtctatgc taatacacaa     2280

ctggtactgc agagaccggc tgtgggtacg gtacacgtgc catactctca ggcaccatct     2340

ggctttaagt attggctaaa agaacgcggg gcgtcgctgc agcacacagc accatttggc     2400

tgccaaatag caacaaaccc ggtaagagcg gtgaactgcg ccgtagggaa catgcccatc     2460

tccatcgaca taccggaagc ggccttcact agggtcgtcg acgcgccctc tttaacggac     2520

atgtcgtgcg aggtaccagc ctgcacccat tcctcagact ttgggggcgt cgccattatt     2580

aaatatgcag ccagcaagaa aggcaagtgt gcggtgcatt cgatgactaa cgccgtcact     2640

attcgggaag ctgagataga agttgaaggg aattctcagc tgcaaatctc tttctcgacg     2700

gccttagcca gcgccgaatt ccgcgtacaa gtctgttcta cacaagtaca ctgtgcagcc     2760

gagtgccacc ccccgaagga ccacatagtc aactacccgg cgtcacatac caccctcggg     2820

gtccaggaca tctccgctac ggcgatgtca tgggtgcaga agatcacggg aggtgtggga     2880

ctggttgttg ctgttgccgc actgattcta atcgtggtgc tatgcgtgtc gttcagcagg     2940

cactaa                                                                2946


<210>  233
<211>  1509
<212>  DNA
<213>  ArtSeq 	pGP58

<400>  233
atgcagctga gcatgagcag cctgatcggc ttcggcaccc tggtgctggc cctgagcgcc       60

cagaccttcg acctgcaggg cctgagctgc aacaccgaca gcacccccgg cctgatcgac      120

ctggagatca ggaggctgtg ccacaccccc accgagaacg tgatcagctg cgaggtgagc      180

tacctgaacc acaccaccat cagcctgccc gccgtgcaca ccagctgcct gaagtaccac      240

tgcaagacct actggggctt cttcggcagc tacagcgccg acaggatcat caacaggtac      300

accggcaccg tgaagggctg cctgaacaac agcgcccccg aggacccctt cgagtgcaac      360

tggttctact gctgcagcgc catcaccacc gagatctgca ggtgcagcat caccaacgtg      420

accgtggccg tgcagacctt cccccccttc atgtactgca gcttcgccga ctgcagcacc      480

gtgagccagc aggagctgga gagcggcaag gccatgctga gcgacggcag caccctgacc      540

tacaccccct acatcctgca gagcgaggtg gtgaacaaga ccctgaacgg caccatcctg      600

tgcaacagca gcagcaagat cgtgagcttc gacgagttca ggaggagcta cagcctggcc      660

aacggcagct accagagcag cagcatcaac gtgacctgcg tgaactacac cagcagctgc      720

aggagcaagc tgaggaggag gaggagggac acccagcaga tcgagtacct ggtgcacaag      780

ctgaggccca ccctgaagga cgcctgggag gactgcgaga tcctgcagag cctgctgctg      840

ggcgtgttcg gcaccggcat cgccagcgcc agccagttcc tgaggggctg gctgaaccac      900

cccgacatca tcggctacat cgtgaacggc gtgggcgtgg tgtggcagtg ccacagggtg      960

aacgtgacct tcatggcctg gaacgagagc acctactacc cccccgtgga ctacaacggc     1020

aggaagtact tcctgaacga cgagggcagg ctgcagacca acacccccga ggccaggccc     1080

ggcctgaaga gggtgatgtg gttcggcagg tacttcctgg gcaccgtggg cagcggcgtg     1140

aagcccagga ggatcaggta caacaagacc agccacgact accacctgga ggagttcgag     1200

gccagcctga acatgacccc ccagaccagc atcgccagcg gccacgagac cgaccccatc     1260

aaccacgcct acggcaccca ggccgacctg ctgccctaca ccaggagcag caacatcacc     1320

agcaccgaca ccggcagcgg ctgggtgcac atcggcctgc ccagcttcgc cttcctgaac     1380

cccctgggct ggctgaggga cctgctggcc tgggccgcct ggctgggcgg cgtgctgtac     1440

ctgatcagcc tgtgcgtgag cctgcccgcc agcttcgcca ggaggaggag gctgggcagg     1500

tggcaggag                                                             1509


<210>  234
<211>  1488
<212>  DNA
<213>  ArtSeq 	pGP71

<400>  234
agcaggtgca cccacctgga gaacagggac ttcgtgaccg gcacccaggg caccaccagg       60

gtgaccctgg tgctggagct gggcggctgc gtgaccatca ccgccgaggg caagcccagc      120

atggacgtgt ggctggacgc catctaccag gagaaccccg cccagaccag ggagtactgc      180

ctgcacgcca agctgagcga caccaaggtg gccgccaggt gccccaccat gggccccgcc      240

accctggccg aggagcacca gggcggcacc gtgtgcaaga gggaccagag cgacaggggc      300

tggggcaacc actgcggcct gttcggcaag ggcagcatcg tggcctgcgt gaaggccgcc      360

tgcgaggcca agaagaaggc caccggccac gtgtacgacg ccaacaagat cgtgtacacc      420

gtgaaggtgg agccccacac cggcgactac gtggccgcca acgagaccca cagcggcagg      480

aagaccgcca gcttcaccgt gagcagcgag aagaccatcc tgaccatggg cgagtacggc      540

gacgtgagcc tgctgtgcag ggtggccagc ggcgtggacc tggcccagac cgtgatcctg      600

gagctggaca agaccgtgga gcacctgccc accgcctggc aggtgcacag ggactggttc      660

aacgacctgg ccctgccctg gaagcacgag ggcgccagga actggaacaa cgccgagagg      720

ctggtggagt tcggcgcccc ccacgccgtg aagatggacg tgtacaacct gggcgaccag      780

accggcgtgc tgctgaaggc cctggccggc gtgcccgtgg cccacatcga gggcaccaag      840

taccacctga agagcggcca cgtgacctgc gaggtgggcc tggagaagct gaagatgaag      900

ggcctgacct acaccatgtg cgacaagacc aagttcacct ggaagagggc ccccaccgac      960

agcggccacg acaccgtggt gatggaggtg accttcagcg gcaccaagcc ctgcaggatc     1020

cccgtgaggg ccgtggccca cggcagcccc gacgtgaacg tggccatgct gatcaccccc     1080

aaccccacca tcgagaacaa cggcggcggc ttcatcgaga tgcagctgcc ccccggcgac     1140

aacatcatct acgtgggcga gctgagctac cagtggttcc agaagggcag cagcatcggc     1200

agggtgttcc agaagaccaa gaagggcatc gagaggctga ccgtgatcgg cgagcacgcc     1260

tgggacttcg gcagcgccgg cggcttcctg agcagcatcg gcaaggccct gcacaccgtg     1320

ctgggcggcg ccttcaacag catcttcggc ggcgtgggct tcctgcccaa gctgctgctg     1380

ggcgtggccc tggcctggct gggcctgaac atgaggaacc ccaccatgag catgagcttc     1440

ctgctggccg gcgtgctggt gctggccatg accctgggcg tgggcgcc                  1488


<210>  235
<211>  1607
<212>  DNA
<213>  ArtSeq 	pGP29.3

<400>  235
acgtgagatc gccaccatgg tgcctcaggc tctgctgctg gtccctatcc tgggattcag       60

ctcctgcttc ggcaagttcc ccatctacac catccctgac accctgggcc cttggtcccc      120

aatcgacatc caccacctga gctgccccaa caacctggtc gtggaggatg aaggctgtac      180

caatctgagc ggcttcagct acatggaact gaaggtggga tatatcagcg ccatcaaggt      240

gaatggcttc acctgcaccg gcgtggtgac cgaggccgag acatacacaa acttcgtggg      300

ctacgtgacc acaaccttca agcggaagca cttcagacct acaccagacg cctgtagagc      360

cgcctacaac tggaagatgg ccggagatcc cagatacgag gaatctctgc acagccccta      420

ccccgactac cactggctga gaaccgtgaa gacaaccaag gaatccctgg tgattatcag      480

ccctagcgtg gccgacctgg acccttacga caacagccta catagcagag tgtttccttc      540

tggcaagtgt agcggcatca ccgtgtccag cgtgtactgc agcaccaacc acgactacac      600

cgtttggatg cctgagagcc tgcggctggg gaccagctgc gacattttta ctaatagcag      660

aggaaaacgg gcttctaaag gatctaaaac ctgtggcttt gtggacgaga gaggcctgta      720

caaatctctg aaaggcgcct gcaagctgaa gctgtgcggc gttctgggcc tcagactgat      780

ggacggcacc tgggttgcta tgcaaacaag caacgagaca aagtggtgtc ctcctgacca      840

gttggtgaac ctgcacgatc tgcggtctga tgagatcgag cacctggtga tcgaggaact      900

ggtcaagaag cgcgaggaat gcctggatgc cctggaaagc atcattacaa ccaaatcagt      960

gtcttttaga cggctgtcct acctgcggaa gctggtgccc ggcttcggca aggcctatac     1020

aatctttaac aagaccctga tggaagcaga agcccactac aagagcgtgc ggacctggaa     1080

cgaaatcatc cctagcaagg gctgcctgag ggtggggggc agatgccacc ctcacgtgaa     1140

cggcgtgttc ttcaacggca tcatcctggg ccctgacggc cacgtgctga tccctgagat     1200

gcagagctct ctgctgcagc agcacatcga gctgctcgag agctctgtga tcccactgat     1260

gcaccccctg gccgatcctt tcaccgtttt caaggacggc gacgaaacag aagatttcat     1320

cgaggtgcat ctgcccgacg tgcacgagca ggtgtctgga gtggacctgg gcctgcctaa     1380

ttggggcgaa tacgtgctgc tgagcgctgg cacccttatc gccctcatgc tgatcatctt     1440

cctgatgacc tgctgcagaa aggtggatag accagagagc acccagcgga gcctgagagg     1500

caccggaaga aacgtgtccg tgacaagcca gagcggcaag ttcatcccca gctgggagtc     1560

ttataagagc ggaggcgaga caggcctgtg aattcacccc accagtg                   1607


<210>  236
<211>  1607
<212>  DNA
<213>  ArtSeq 	pGP29.4

<400>  236
acgtgagatc gccaccatgg ttcctcaggt gctgctcttc gtgcctctgc tggtcttttc       60

catgtgcttc ggcaaattcc ccatctacac catcccagac aagctgggcc cttggagccc      120

tatcgacatc caccacctga gctgccctaa caacctcgtg gtggaagatg agggctgtac      180

aaacctgtct ggcttttctt atatggagct gaaagtggga tacatcagcg ccatcaaggt      240

gaacggcttc acctgcaccg gcgtggtgac agaggccgag acatacacca acttcgtggg      300

ctacgtgaca accaccttca agagaaagca cttccggcct acccctgacg cctgcagagc      360

cgcttacaac tggaagatgg ccggcgatcc tagatacgag gaaagcctgc ataatcctta      420

tcctgactac cactggctga gaacagtgaa aaccaccaag gaatccctgg tgatcatcag      480

cccctctgta gccgatctgg acccctacga caagagcctg cacagcagag tgttccctag      540

cggaaaatgc agcggtatca ccatctctag cacatactgc agcaccaacc acgactacac      600

gatctggatg cccgagaacc ccagactggg cacctcctgc gacattttta caaatagccg      660

gggcaagcgg gccagcaagg gcggcaagac atgcggcttc gtggacgaga gaggcctgta      720

caaaagcctg aagggcgcct gtaaactgaa gctgtgcgga gtgcttggcc tgcgactgat      780

ggacggcaca tgggtggcca tgcaaacaag cgatgaaacc aagtggtgcc cacctgacca      840

gctggtgaac ctgcatgatt tcagaagcga cgaaatcgag cacctggtgg tcgaggaact      900

ggtgaagaag cgggaggagt gcctggatgc cctggaaagc atcatggcta caaagagcgt      960

gtcatttcgc agactgagcc acctgcggaa gctggtgcct ggcttcggca aagcctacac     1020

catcttcaac aagaccctga tggaagctga tgcccactac aagtctgtgc ggacctggaa     1080

cgagatcatt cccagcaagg gatgtctgag agtgggcgga aggtgccacc cccacgtgaa     1140

tggcgtgttc ttcaacggca tcatcctggg ccccgacggc cacgtgctga tcccagagat     1200

gcagagcagc ctgctgcagc agcacatgga actgctggaa tctagcgtga tccctctgat     1260

gcaccccctg gccgaccctt ctaccgtgtt taaggacgga gatgaggctg aggacttcgt     1320

ggaagtgcat ctccctgacg tgcacaagca gatctctggc gttgatctgg gactgcctag     1380

ctggggcaag tacgtgctgg tgtccgcagg cgtgctggtg gtcctgatgc tgaccatttt     1440

catcatgacc tgttgtggca gagtgcacag acccaagtcc acccagcacg gcctgggcgg     1500

aaccggcaga aaggtgtccg tcaccagcca gtctggcaaa gtaatcagca gctgggagag     1560

ctacaagagt ggaggcgaga caagactgtg aattcacccc accagtg                   1607


<210>  237
<211>  1607
<212>  DNA
<213>  ArtSeq 	pGP29.5

<400>  237
acgtgagatc gccaccatgg tgcctcaggt gctgctgttc gtgccactgc tgggatttag       60

cctgtgcttc ggaaaattcc caatctacac catccccgat aagctggggc cttggagccc      120

tatcgacatc caccacctgt catgccccaa caacctggtg gtggaagatg agggctgcac      180

caacctgagc gagttcagct acatggaact gaaagtgggc tacatcagcg ccatcaaggt      240

gaatggcttc acctgcaccg gagtagtgac cgaggccgaa acctacacaa acttcgtggg      300

ctacgtcaca accacattca agagaaagca cttccggccc acccctgatg cttgtagagc      360

cgcttacaac tggaagatgg ccggcgaccc tcggtacgag gaaagcctgc acaaccctta      420

tcctgactac cactggctga gaacagtgag aaccaccaaa gagtctctca tcattatcag      480

ccctagcgtg acagacctgg atccttacga caagtccctc cattctcggg tgtttccagg      540

cggaaagtgc agcggcatca ccgtgagctc tacctactgc agcaccaacc acgactatac      600

aatctggatg cccgagaacc ccagacccag aacaccgtgc gacatcttca ccaacagcag      660

agggaaaaga gccagcaaag gcaacaaaac ctgtggcttc gtggacgaaa gaggcctgta      720

taagtccctg aagggagcct gcagactgaa gctgtgcggc gtgctgggcc ttagactgat      780

ggacggcacc tgggtggcca tgcagacaag cgacgagaca aagtggtgtc ctcctgacca      840

gctggtcaac ctgcatgatt tccgcagtga cgagatcgag cacctggtcg tggaagagct      900

ggttaagaag cgggaagagt gtctggacgc cctggaaagc atcatgacca ccaagagcgt      960

gtccttccgg agactgagcc acctgagaaa gctggtgccc ggctttggca aggcctacac     1020

catctttaac aagaccctga tggaagccga cgcccactac aagagcgtgc ggacctggaa     1080

cgagatcatt cccagcaagg gctgtctgaa agtgggaggc cggtgccacc ctcacgtgaa     1140

tggcgtcttt ttcaacggca tcatcctggg ccctgacggc cacgtgctga ttcctgagat     1200

gcaatctagc ctcctgcagc agcacatgga actgctgaag tctagcgtga tccctctgat     1260

gcaccccctg gccgatcctt ctaccgtgtt caaggaaggc gatgaggccg aggacttcgt     1320

cgaggtgcac cttcctgacg tgtacaagca gatctccggc gtggatctgg gactgcctaa     1380

ttggggcaag tacgtgctga tgacagccgg agctatgatc ggcctggtgc tgatcttctc     1440

cctgatgacc tggtgcagac gggctaatag acctgagtcc aaacagagaa gcttcggcgg     1500

cacaggcagg aacgtgtctg tgacatctca gagcggcaag gtgatcccaa gctgggagag     1560

ttacaagagc ggcggagaaa tcagactgtg aattcacccc accagtg                   1607


<210>  238
<211>  1607
<212>  DNA
<213>  ArtSeq 	pGP29.6

<400>  238
acgtgagatc gccaccatgg tgcctcaggc cctgttgttt gtgccactcc tggtgttccc       60

actgtgcttc ggcaaattcc ctatctacac catcctggat aagctgggcc catggagccc      120

catcgacatc caccacctgt cttgtcctaa caacctggtg gtcgaggatg agggctgcac      180

caatctgagc ggcttcagct acatggagct gaaggtgggc tacatcctgg ccatcaagat      240

gaacggcttc acctgtacag gagtggtgac cgaggccgag acttatacaa acttcgtggg      300

ctacgtgaca acaaccttca agcggaagca cttcagacct acacctgatg cctgtagagc      360

cgcttacaac tggaaaatgg ccggcgatcc aagatacgag gaatctctcc ataatcctta      420

tcctgattac agatggctgc gcaccgtgaa gaccaccaaa gagtccctgg tcatcatctc      480

ccctagcgtg gccgacctgg acccttacga ccggagcctg cacagcagag tgttcccttc      540

cggcaagtgc agcggcgtgg ccgtgagctc cacctactgc tctacaaacc acgactacac      600

catctggatg cctgaaaacc ccagactggg aatgagctgc gacatcttca caaacagccg      660

gggcaagcgg gcctctaagg gcagcgagac ctgcggattt gtggacgaaa gaggcctgta      720

caagagcctc aaaggcgcct gcaagctgaa gctgtgtggc gtgctgggtc tcagactgat      780

ggacggcaca tgggtggcca tgcagaccag caacgagacc aaatggtgcc cccccgacca      840

gctggtgaac ctgcacgact tccggagcga cgagatcgag cacctggtgg tggaagaact      900

ggttagaaag cgggaagagt gcctggacgc tctggaaagc atcatgacca ccaagagcgt      960

ttcttttcgg cggctgagcc acctgagaaa actggtgccc ggcttcggaa aggcctacac     1020

catcttcaac aagacactga tggaagctga tgcccactac aagtctgtga ggacatggaa     1080

cgagattctg cctagcaagg gatgtctgag agtgggcgga agatgccacc cccacgtgaa     1140

tggcgtgttt ttcaacggca tcatcctggg ccctgatggc aacgtgctga tccctgagat     1200

gcaaagcagc ctgctgcagc agcatatgga actgctggaa agctctgtta tccccctggt     1260

gcatcctctg gctgacccca gtaccgtgtt caaggacggc gacgaggctg aggacttcgt     1320

ggaagtgcac ctgcccgatg ttcacaacca ggtgtccggc gtcgacctgg gcctgcctaa     1380

ttggggcaag tacgtgctgc tgagcgccgg cgccctgacc gccctgatgc tgatcatctt     1440

cctgatgaca tgctgcagaa gggttaacag aagcgagcct acccagcaca acctgcgcgg     1500

gaccggcaga gaggtgtctg tgacacctca gtctggaaag atcattagca gctgggagtc     1560

ccacaagagc ggaggagaaa ccagactgtg aattcacccc accagtg                   1607


<210>  239
<211>  1607
<212>  DNA
<213>  ArtSeq 	pGP29.7

<400>  239
acgtgagatc gccaccatgg tgccccaggc ccttctgttc gtgcctctgc tggtctttcc       60

tctgtgtttc ggcaagttcc ccatctacac aatccctgat aagctgggcc cttggtcccc      120

tatcgacatc caccacctgt cttgccctaa caacctggtc gtggaagatg agggctgtac      180

aaatctgagc ggcttcagct acatggaact caaagtgggc tacatcctgg ctatcaaggt      240

gaacggattt acctgtaccg gcgtggtgac cgaggctgaa acctacacca acttcgtggg      300

atatgtgaca accacattca agcggaagca cttccggcct accccagacg cctgcagagc      360

cgcttataac tggaagatgg ccggagatcc tagatacgag gaaagcctgc acaaccctta      420

ccccgattac agatggctgc gcaccgtgaa gaccacaaag gaaagcctgg tgatcatttc      480

tccttctgtc gccgatctgg acccttacga cagaagcctg cacagcagag tgtttcctag      540

cggcaaatgc agcggcgtgg ccgtgagcag tacatactgc agcaccaacc acgactacac      600

catttggatg ccagagaacc ccagactggg catgagctgc gacatcttca ccaacagccg      660

gggaaaacgg gcctctaagg gcagcgagac atgtggcttc gttgacgaga gaggcctgta      720

caagtcactg aagggcgcct gcaagctgaa gctgtgcggc gtcctgggcc taagactgat      780

ggacggcacc tgggtgtcca tgcaaacaag caacgagacc aagtggtgcc cccccgacaa      840

gctggtgaat ctccatgatt tcaggtctga tgagatcgag cacctggtgg tcgaggaact      900

ggtgcggaaa agagaagagt gcctggatgc tcttgagagc atcatgacaa ccaagagcgt      960

gtccttcaga cggctgagcc acctgagaaa gctggttcct ggcttcggca aagcctacac     1020

catcttcaac aagaccctga tggaggccga cgcccactac aagtccgtgc ggacctggaa     1080

cgagatcctg ccaagcaagg gatgtctgcg ggtgggcggc agatgccacc cccacgtgaa     1140

cggcgttttc ttcaacggca tcatcctggg tcctgacgga aatgtgctga tccccgagat     1200

gcagagcagc ctgctgcagc agcacatgga actgctggaa tcttctgtga tcccactggt     1260

gcatcctctg gccgacccta gcacagtgtt taaggacggc gacgaggccg aggacttcgt     1320

ggaagtgcac ctgcccgacg tgcacaacca ggtgagcggc gtggacctgg gtctgcctaa     1380

ttggggcaaa tacgtactgc tgagcgccgg cgctctgacc gccctgatgc tgatcatctt     1440

tctgatgacc tgctgccgga gagtgaacag aagcgagccc acccagcaca atctgagggg     1500

cacaggaaga gaggtgtccg tgacccctca gagcggcaag atcatcagct cttgggaaag     1560

ccacaagagc ggcggagaaa ccagactgtg aattcacccc accagtg                   1607


<210>  240
<211>  1607
<212>  DNA
<213>  ArtSeq 	pGP29.8

<400>  240
acgtgagatc gccaccatgg tgccccaggc cctgcttttc gtgccactgc tggtgttccc       60

tctgtgcttc ggcaagttcc ccatctacac aatccctgat aagctgggcc cttggtcccc      120

tatcgacatc caccacctga gctgtcctaa caacctggtg gtggaggacg agggctgcac      180

aaatctgagc ggcttcagct acatggagct gaaggtgggc tacatcctgg ctatcaagat      240

gaacggattc acctgcaccg gagtggtgac cgaggctgaa aactacacca atttcgtggg      300

ctacgtcacc acgacattca aaagaaagca cctgcggccc acacctgacg cctgtagggc      360

cgcttacaac tggaaaatgg ccggcgaccc tagatacgag gaatccctgc acaaccccta      420

tcctgattac agctggctga ggaccgtgaa gaccaccaag gaaagcctcg tcatcatcag      480

ccctagcgtg gccgatctgg atccttacga cagaagcctc cattctcggg tgtttccaag      540

cggcaagtgc agcggcgttg ccgtgtctag cacctactgc agcaccaacc acgattacac      600

catctggatg cctgagaacc ctagactggg caaaagctgc gacatcttca caaatagcag      660

aggaaaacgg gcctctaagg gcagcgaaac ctgtggcttt gtggacgaga gaggcctgta      720

caagagcctg aaaggcgcct gcaagctgaa actctgcggc gtgctgggcc tgagactgat      780

ggacggcacc tgggtggcca tgcaaaccag caacgagaca aagtggtgcc cacctgacca      840

gctggtgaac ctgcacgact tccggagcga cgagatcgag cacctggtag tggaagagct      900

ggtgcggaag cgggaagagt gcctggacgc tctggaaagc atcatgacca ccaagtccgt      960

gtcttttaga cggctgtccc acctgcggaa gctggtcccc ggcttcggca aggcctatac     1020

catctttaac aagaccctga tggaagccga cgcccactac aagtccgtca gaacctggaa     1080

cgagatcctg cctagcaagg gatgtctgag agtgggcgga agatgccacc cccacgtgaa     1140

cggcgtgttc ttcaacggca tcatcctggg ccccgatggc aacgtgctga tccccgagat     1200

gcagagcagc cttctccagc agcacatgga actgctggaa agctctgtta ttccactggt     1260

gcaccctctg gccgaccctt ctacagtgtt caaggacggc gatgaggccg aggacttcgt     1320

ggaagtgcat ctgcctgatg tgcacaacca ggtgtccgga gtggacctgg gcctgcccaa     1380

ctggggaaaa tacgtgctgc tgagcgccgg agccctgacc gccctgatgc tgatcatttt     1440

cctgatgacc tgttgcagaa gagtgaatag aagcgagcct acacagcaca atctgcgcgg     1500

aacaggcaga gaagtcagcg tgacacctca gacctggaag atcatctcta gttgggagag     1560

tcacaagtct ggcggcgaga caagactgtg aattcacccc accagtg                   1607


<210>  241
<211>  1607
<212>  DNA
<213>  ArtSeq 	pGP29.9

<400>  241
acgtgagatc gccaccatgg tcccccaggc cctgctgttc gtgccactgc tggtgtttcc       60

tctctgcttc ggaaaattcc ctatctacac catccccgat aagctgggcc catggagccc      120

catcgacatc caccacctga gctgccccaa caacctggtg gtggaggacg agggctgtac      180

caacctgtcc ggctttagct acatggaact gaaggtgggc tacatcagcg ccatcaagat      240

gaacggcttc acatgtacag gcgtggtgac cgaggctgaa acttatacca acttcgtggg      300

ctatgtgaca accacattca agagaaagca cttccgcccc acccctgatg catgtagagc      360

cgcttacaac tggaagatgg ccggcgaccc tagatacgag gaaagcctgc ataatcctta      420

ccccgactac cactggctga gaacagtgaa gaccaccaag gaatctctgg ttatcatctc      480

accttctgtg gctgacctgg acccctacga cagatccctg cacagcagag tgttccctgg      540

cggcaattgc agcggcgtgg ccgtgtcttc tacatactgc agcacaaacc acgactacac      600

catctggatg cctgagaacc ccagactggg catgagctgc gacatcttca ccaatagccg      660

gggcaagcgg gccagcaagg gcagcgagac ctgtggcttc gtggacgaga gaggcctgta      720

caagagcctg aagggagcct gtaaactgaa gctgtgcggc gtgctgggcc tgcggctgat      780

ggacggcacc tgggtggcca tgcagaccag caacgaaacc aagtggtgcc cacctggaca      840

gctggtgaac ctccatgatt ttcggagcga tgagatcgag caccttgtgg tcgaggaact      900

ggtgaaaaag cgggaagagt gcctggatgc cctggaaagc atcatgacca ccaaaagcgt      960

gtccttcaga agactgtctc acctgagaaa gttggtgcct ggctttggga aggcctacac     1020

catctttaac aagaccctga tggaagccga cgcccactac aagagcgtga ggacctggaa     1080

cgagatcatt ccaagcaagg gctgcctgag agtgggcggt agatgccacc ctcacgtgaa     1140

cggcgtgttc ttcaacggca tcatcctggg ccctgatggc aacgtgctga tccctgagat     1200

gcaatctagc ctgctgcagc agcacatgga actcctggtg tccagcgtga tccctctcat     1260

gcaccccctg gccgatcctt ccacagtgtt caagaacggc gatgaagctg aggacttcgt     1320

tgaggtgcac ctgcctgacg tgcacgagcg gatcagcgga gtggacctgg gactgcctaa     1380

ttggggcaaa tacgtgctgc tgagcgccgg cgccctgacc gccctgatgc tgatcatctt     1440

cctgatgaca tgctggcgga gagtgaatag aagcgagcct acccagcaca acctgcgggg     1500

caccggaaga gaagtgtccg ttacacctca gagcggcaag atcattagca gctgggagtc     1560

ctacaaatct ggcggagaga caggactgtg aattcacccc accagtg                   1607


<210>  242
<211>  1607
<212>  DNA
<213>  ArtSeq 	pGP29.1

<400>  242
acgtgagatc gccaccatgg tgcctcaggt gcttctgttc gtgcccctgc tgggcttcag       60

cctgtgcttc ggaaagttcc ctatctacac catccctgat gagctgggac cttggtcccc      120

aatcgacatc caccacctca gctgccctaa caacctggtg gtggaagatg agggctgcac      180

caacctgagc gagttcagct acatggagct gaaggtggga tacatctccg ccatcaaggt      240

gaacggcttt acctgtaccg gcgtggtgac agaagctgaa acctacacaa atttcgtggg      300

ctacgtgaca acaaccttca agagaaagca cttccggccc acccctgacg cttgccgggc      360

tgcttataac tggaagatgg ccggtgaccc cagatacgag gaatccctgc acaaccctta      420

tcctgattac cactggctga ggaccgtgcg gaccaccaaa gagtccctga tcattatcag      480

ccctagcgtg accgacctgg acccttacga caagagcctg cattctagag gctttccagg      540

tggcaagtgc agcggcatca cagtgtctag cacctactgc agcaccaacc acgactacac      600

catctggatg cctgagaacc ccggccctag aaccccgtgc gacatcttca ccaacagcag      660

aggcaaaagg gccagcaagg gcaacaagac atgcggcttc gtggatgaga gaggcctgta      720

caagtccctg aagggcgcct gtcggctgaa gctctgtggc gtgctgggac tgcggttgat      780

ggacggcaca tgggtcgcca tgcaaacatc tgatgagaca aagtggtgcc cccccgacca      840

gctggtcaac ctgcacgatt tcagatctga cgagatcgag cacctggtgg ttgaggaact      900

ggtgaagaaa cgggaagagt gcctggacgc cctggaatcc atcatgacaa caaagagcgt      960

ctccttccgc agactgagcc acctgagaaa gctggtgcct ggctttggca aggcctacac     1020

catctttaac aagacactga tggaagccga cgcccactac aagtctgtgc gaacctggaa     1080

cgagattatc cccagcaaag gctgtctgaa agttggaggc agatgccacc cccacgtgaa     1140

tggagtcttt ttcaacggca tcatcctggg ccctgacggc cacgtgctga tccccgagat     1200

gcagtctagc ctgctgcagc agcacatgga actgctgaag agcagcgtca tcccactgat     1260

gcaccctctg gccgaccctt caacagtgtt caaggaagga gatgaagccg aggacttcgt     1320

ggaagtgcat ctgcctgatg tgtacaaaca gatcagcggc gtggacctgg gcctgccaaa     1380

ttggggcaag tacgtgctga tgaccgccgg cgccatgatc ggcctggtgc tgatcttcag     1440

cctgatgacc tggtgtagaa gagccaatag acctgagtct aagcagagaa gcttcggcgg     1500

caccggacgg aacgtgtccg tgaccagcca gagcgggaaa gtgatcccta gctgggaatc     1560

atatagaagc ggcggcgaga tccggctgtg aattcacccc accagtg                   1607


<210>  243
<211>  1607
<212>  DNA
<213>  ArtSeq 	pGP29.11

<400>  243
acgtgagatc gccaccatgg tgccccaagc cctgctgctg gtgcctctgc tgggcttttc       60

cctgtgcttc ggcaagttcc ccatctacac catccccacc aaactgggac cttggagccc      120

tatcgacatc caccacctga gctgccccaa caacctggtg gtggaggatg agggatgcac      180

aaacctgagc ggcttcagct acatggaact gaaggtggga agaatcagcg ccatcaaggt      240

caacggcttc acctgtacag gcgtggtgac cgaggctgaa acatacacaa atttcgtggg      300

atacgtgacc accactttta agagaaagca cttcagacct atgcccggct gcatgtacag      360

ccgggtgcag ctggaagatg gtcgctcccc tcaaatcgag gaatctctgc acaaccccta      420

tcctgattac cactggctga gaaccgtgcg gaccacaaag gaatccctga tcattatctc      480

tccaagcgtg accgacctgg atccttacga caagagcctg cacagcaggg tgttcccagg      540

cagaaagtgc agcgggatca cagtgagcag cacctactgc agcaccaatc acgattatac      600

agtgtggatg cctgagatcc tgcggctggg aacatcttgt gacatcttta caaatagcag      660

aggaaagaga gcctctaagg gcagcaagac ctgcggcttc gtggacgaga gaggcctgta      720

caagtccctg aaaggcgcct gcaagctgaa gctctgtggc gtgcctggcc tcagactgat      780

ggacggcacc tgggtcgcca tgcagaccag caacgagaca aagtggtgcc ctcctggcca      840

gctggtgaac ctgcacgacc tgcatagcga cgaaattgag cacctggtgg tggaagagct      900

ggtgaagaaa agagaggaat gcctggacgc cctggaaagc attaccacaa ccaagagcgt      960

ctccttccgg agactgagcc acctgagaaa gctggtgcct ggctttggaa aggcctacac     1020

catcttcaac aagaccctga tggaagctga ggctcactac aagagcgtgc ggacctggaa     1080

cgagatcatc ccatctaaag gctgccttcg ggttggcggc ggatgtcacc cccacgtgaa     1140

tggcgttttc ttcaacggca tcatcctggg ccctgatggc cacgtgctga tccctgagat     1200

gcagtcttct ctcctgcagc agcacatcga gctgctggaa agcagcgtga tccccctgat     1260

gcaccctctg gccgacccat tcaccgtttt caaagacggc gacgagatcg aggatttcgt     1320

ggaagtgcat ctgcccgacg tgcacgagca ggtgtctggc gtcgacctgg gcctgcctaa     1380

ctggggcgag tacgtgctcc tgagcgccgg cacactgatc gccctgatgc tgatcatctt     1440

tctgatcacc tgctgtaaaa gagtggatag acccgagtct acacagcgga gcctgagagg     1500

caccggaagg aacgtgtccg tgaccagcca gagcggcaag ttcatcccta gcagagaatc     1560

ttacaagtcc ggcggcgaga ccggcctgtg aattcacccc accagtg                   1607


<210>  244
<211>  1607
<212>  DNA
<213>  ArtSeq 	pGP29.12

<400>  244
acgtgagatc gccaccatgg tgccccaggt gctgctgttc gtgttactgc tgggattcag       60

cctgtgtttt ggcaagttcc caatctacac catccccgac gagctgggcc cttggagccc      120

tatcgacatc caccacctgt cctgccccaa caacctggtc gtcgaggacg agggctgtac      180

caacctgagc gagttcagct acatggagct gaaggtgggc tacatcagcg ccatcaaggt      240

gaatggattt acctgtacag gcgtggtgac cgaggccgag acatacacaa acttcgtggg      300

ttatgtgacc accaccttca agagaaagca cttcagacct acacctgacg cgtgcagagc      360

tgcttacaac tggaagatgg ccggagatcc tagatacgag gaatccctgc ataatcctta      420

tcctgattac cactggctgc ggaccgtgcg gacaaccaag gaaagcctga tcatcatcag      480

ccctagcgtt accgacctgg acccctacga caagagcctg cacagcagag tgttccccgg      540

cagaaagtgc agcggcatca ccgtgtccag cacctactgc agcaccaacc acgactacac      600

catctggatg cctgagaacc cccggcctag aacaccgtgc gacatcttca ccaacagcag      660

aggaaaacgc gcttctaacg gcaacaagac atgtggcttc gtggacgaaa gaggcctgta      720

caaaagcctc aagggcgctt gtagactgaa gctgtgcggc gtgctgggcc tgagactgat      780

ggacggcacc tgggtggcca tgcagaccag cggagaaacc aaatggtgcc cacctgatca      840

gctggtgaac cttcatgatt ttagatctga tgagatcgag cacctggtgg tggaagagct      900

ggtcaagaag cgggaggaat gcctggatgc cctggagagc atcatgacca caaagtctgt      960

ctcctttcgg agactgagcc acctgagaaa actggttcct ggcttcggca aggcctacac     1020

catctttaac aagaccctga tggaagccga cgcccactac aagtccgtgc ggacatggaa     1080

tgagattatc ccctctaaag gctgcctgaa agtgggcgga agatgccacc cccacgtgaa     1140

cggtgtgttc ttcaacggcc tgatcctggg acctgacgac cacgtgctga tcccagaaat     1200

gcagagcagc ctgctgcagc aacacatgga actgctggaa tcttctgtga tccctctgat     1260

gcaccctctg gccgatcctt ctacagtgtt caaggaaggc gacgaggccg aggatttcgt     1320

tgaagtgcac ctgcctgacg tgtacaagca gatcagcggc gtggacctgg gccttcctaa     1380

ctggggcaaa tacgtgctga tgacagccgg cgccatgatc ggcctggtgc tcatcttcag     1440

cctgatgacc tggtgcaggc gggccaacag acccgagtcc aagcagagaa gcttcggcgg     1500

cacaggcgga aatgtgtctg tgacatctca gagcggcaag gtgatcccaa gctgggagtc     1560

atacaagagc gggggcgaga ttcggctgtg aattcacccc accagtg                   1607


<210>  245
<211>  1607
<212>  DNA
<213>  ArtSeq 	pGP29.13

<400>  245
acgtgagatc gccaccatgg tgcctcaggc cctgttgttc gtgcccctgc tggtgttccc       60

cctgtgcttc ggcaagttcc ctatctacac cattccagac aagctgggcc cttggtcccc      120

aatcgacatc caccacctgc ggtgccctaa caacctggtg gtcgaggacg agggctgtac      180

caacctgagc ggattcagct acatggaact gaaagtgggc tacatcagcg ccatcaaggt      240

gaatggcttc acctgtaccg gcgtggtgac cgaggccgag acatacacca acttcgtggg      300

ctatgtcaca acaactttta agagaaagca cttccggcct acccctgatg cttgtagagc      360

cgcttacaac tggaagatgg ccggcgaccc tagatacgag gaatccctgc acaaccctta      420

tcctgattac cactggctga gaaccgtgaa gaccacaaag gaaagcctgg tgatcatcag      480

ccctagcgtg gccgatctgg atccttacga caagtccctg cacagcagag tgtttccttc      540

tggcaactgc agcggaatca cagtttctag cacatactgc agcaccaacc acgactacac      600

catctggatg cctgagaacc ccagactgga aaccagctgc gacatcttca ccaatagccg      660

gggcaagaga gcctctaagg gcagcaagac atgcggcttc gtggacgaga gaggcctgta      720

caaaagcctg aagggcgcct gcaaactgaa actgtgtggc gtgctgggac tgagactgat      780

ggacggcacc tgggtggcca tgcaaacatc agatgaaacc aaatggtgcc cacctgacca      840

gctggtgaac ctgcatgact tcagaagcga cgaaatcgag cacctggtgg tggaagagct      900

ggtgaaaaag cgggaagagt gcctggacgc cctggaaagc atcatgacca ccaagagcgt      960

ctccctgaga cggctttctc acctgagaaa gctggtcccc ggctttggca aggcctacac     1020

aatctttaac aagaccctga tggaagctga ggcccactac aagagcgtgc agacctggaa     1080

cgagatcatc cccagcaagg gttgtctgag ggtgggcggc agatgccacc cccacgtgaa     1140

tggagtgttc ttcaatggca tcatcctggg acctgatggc cacgtgctga ttccagagat     1200

gcagagctct ctgctccagc agcacatgga attactcgag agcagcgtga tccctctgat     1260

gcaccctctg gccgacccct ctaccgtgtt taaggacgga gatgaagccg aggatttcgt     1320

tgaagtgcac ctgcctgacg tgcataagca ggtgtccgga gtggacctgg gcctgcccaa     1380

ctggggcaag tacgtgctgc tgagcgctgg cacactgatc gccctgatgc tgatcatctt     1440

cctgatgacc tgctgcagac gcgtgaacag acctaagtcc accgagcgga gcctgggcga     1500

gacaggccgg aaggtgtccg tgaccagcca gtctggcaaa gtgatcagca gctgggagtc     1560

ttacaagagc ggaggcgaga caagacggtg aattcacccc accagtg                   1607


<210>  246
<211>  1607
<212>  DNA
<213>  ArtSeq 	pGP29.14

<400>  246
acgtgagatc gccaccatgg tcccccaggt gctgctgttc gcccctctgc tggtgtttcc       60

actgtgcttc ggcaagttcc ctatctacac aatccctgac aagctcggac cttggtcccc      120

tatcgacctg caccacctgt cctgccccaa caacctggtg gtcgaggacg aaggctgtac      180

caatctgagc ggattcagct acatggagct gaaggtgggc tacatcagcg ccatcaaggt      240

gaacggcttc acatgtacag gcgtggtgac agaggccgaa acatacacca acttcgtggg      300

ctatgtgacc acaacattca aaagaaagca cttcagaccg acccctgatg cctgcagagc      360

cgcttacaac tggaagatgg ccggcgatcc tagatacgag gagtctctgc ataatcctta      420

tcctgattac cactggctgc ggaccgtgaa gacaaccaag gaatctctgg tgatcatttc      480

tccttctgtg acagacctgg atccttacga caagagcctg cacagcagag tcttccccgg      540

cggcaactgc agcggcatca ccgtgtccag cacatactgc agcaccaacc acgactacac      600

catctggatg cctgagaacc tgcggctggg cactagctgc gacatcttta cccactctag      660

aggcaaacgg gccagcaagg gagataagac ctgtggcttt gtggatgaac ggggcctgta      720

caaatccctg aagggagcct gtaaactgaa actgtgcggc gtgctgggtc tgcgcctgat      780

ggacgggacc tgggtggcca tgcaaaccag cgacgagaca aagtggtgcc ctcctggcca      840

gctggtcaac ctccatgatt tcagaagcga cgagatcgag cacctggtgg aagaggagct      900

tgttaagaag agagaagagt gcctggacgc tctggaatcc atcatgacca caaaaagcgt      960

gtcttttcgg cggctgagcc acctgaggaa gctggtgccc ggcttcggca aggcctacac     1020

catcttcaac aagaccctga tggaagctga tgcccactac aaaagcgtgc agacctggaa     1080

cgagatcatc ccttctaagg gatgtctgcg agtgggcgag cggtgccacc ctcacgtgaa     1140

tggcgttttc ttcaacggca tcatcctggg atctgacggc cacgtgctga ttccagagat     1200

gcagagcagc ctgctgcaac agcacatgga gctgctggaa agcagcgtga tccccctgat     1260

gcaccccctg gccgacccca gcaccgtgtt caaggacggc gacgaggtgg aagattttgt     1320

ggaagtccac ttgcctgacg tgcacaagca ggtgtccggc gtggacctgg gcctacccaa     1380

gtggggaaag tacgtgctga tgatcgctgg cgccctgatc gccctgatgc tgattatctt     1440

cctgatgacc tgctgcagaa gagtgaacag acctgagagc acccagtcta atctgggtgg     1500

caccggcaga aacgtgtccg tgcctagcca gagcggcaag gtgatcagca gctgggagag     1560

ctacaagagc ggcggagaaa ccagactgtg aattcacccc accagtg                   1607


<210>  247
<211>  1607
<212>  DNA
<213>  ArtSeq 	pGP29.15

<400>  247
acgtgagatc gccaccatga tcccacaggc cctgctgttc gtgcccctgc tgatccccag       60

cctgtgtctg ggcaaattcc ccatctacac cattcctgat aagctgggcc cttggagccc      120

tatcgacatc caccacctga gctgccccaa caacctggtg gtcgaggacg agggctgtac      180

tagcctgtcc ggatttagct acatggagct gaaggtgggc tacatcagcg ccatgaaagt      240

gaacggattc acctgcaccg gcgtggtgac cgaggccgag acatacacca acttcgtcgg      300

atacgtcaca acaacattca agcggaagca cttcagacct atgccagacg cctgcagagc      360

tgctcacgac tggaagatcg ccggcgatcc acggtacgag gacagcctgc aaaatcctta      420

tcctgattac cactggctga ggacagtgaa gaccaccaag gaaagcctag tgatcatcag      480

tccttctgtg gctgatctgg atccttacga caagagcctg cattctagag tgtttcctag      540

cggcaagtgc ctgggtatca ccgtgtctag cacctactgc cctacaaatc acgattacac      600

tatctggatg cctgtggaag ccagactggg aacaagttgc gacatcttta ccaacagccg      660

gggcaagaag gccagcaaag gcggaagaac ctgtggcttt gtggacgaaa gaggccttta      720

taagagcctg aagggcgcct gtaaactgaa gttgtgcgga gttcctggcc tgagactgat      780

gaacggcaca tgggtgtcca tccagaccag cgacgacatc aagtggtgcc ctcccgatca      840

gctggttaat ctgcacgact tccactctga cgagatcgag cacctggtgg tggaggaact      900

gatcaagaaa agagaaggat gtctcgatgc cctggaaagc atcatgacca caaagtccgt      960

ctccttccgg cgcctgagcc acctgagaaa gctggtcccc ggcttcggca aagcctacac     1020

catcttcaac aacaccctga tggaagccga cgcgcactac aagtctgtta gaacctggaa     1080

cgaggtgatc ccttctaaag gctgcctgaa ggtgggaggc agatgccacc ctcctgtgaa     1140

cggcgtgttc ttcaacggca tcatcctggg cccagacggc aacgtgctga tccctgagat     1200

gcagagctct ctgctgcagc agcacatgga actgctcgaa agcagcgtga tccccctgat     1260

gcaccccctg gctgacccct ccaccgtgtt caaggacggc gacgaggctg aagatttcgt     1320

ggaagtgcac ctgcccgacg tgcataagca ggtgtccgac gtggacctgg gcctgcctag     1380

ctggggcaag tacctgctca tgagcgccgg agccctggcc accctgattc tggccatctt     1440

cctgattaca tgctgcagac gggccaatcg gaccaagtct acccagcggg gccacagaga     1500

gagcggcggc aaggtgagcg tggcccctca aaacggcaaa atcatcagca gctgggagct     1560

gtacaagagc gagagcgaga caggcatgtg aattcacccc accagtg                   1607


<210>  248
<211>  1575
<212>  DNA
<213>  ArtSeq 	pGP29.2

<400>  248
atggtgcccc aggccctgct cttcgtgcct ctgctcgtct ttccactgtg cttcggcaaa       60

tttcccatct acactattcc tgacaagctg ggaccctgga gtcctatcga tattcaccat      120

ctgtcatgcc ctaacaatct cgtggtcgag gatgaagggt gtaccaacct gtcaggtttc      180

agctacatgg agctgaaagt ggggtatatc ctcgctatta aggtcaacgg cttcacatgc      240

actggagtgg tcaccgaggc agaaacctac acaaattttg tgggctatgt caccacaact      300

ttcaagagga aacactttag accaacaccc gacgcctgtc gcgccgctta caactggaag      360

atggctggcg atccacgata tgaggaatct ctgcacaatc cttacccaga ctatagatgg      420

ctgcggacag tgaagaccac aaaagagagc ctggtcatca ttagcccatc cgtcgcagac      480

ctggatccct acgatagatc cctgcactct cgggtgtttc cctctggcaa gtgcagtgga      540

gtggccgtca gctccactta ctgtagcacc aaccatgatt atactatctg gatgccagag      600

aatccccggc tgggaatgtc ctgcgacatt ttcacatcta gtcgcgggaa gcgagccagt      660

aaagggtcag agacttgtgg ttttgtggac gaaaggggcc tgtataagag cctcaaagga      720

gcttgcaagc tgaaactctg tggcgtgctg ggactcagac tgatggatgg aacctgggtc      780

tcaatgcaga caagcaacga gactaagtgg tgcccccctg acaaactcgt gaatctgcac      840

gacttcaggt ccgatgagat cgaacatctg gtggtcgagg aactcgtgcg aaaaagggag      900

gaatgtctcg atgctctgga gtctatcatg actaccaagt ctgtgagttt taggagactc      960

agtcacctga gaaagctcgt ccctggcttc ggaaaagcat acaccatctt taacaagaca     1020

ctgatggaag cagacgccca ttataaaagc gtggagacct ggaatgaaat cctgccatcc     1080

aagggatgcc tccgagtcgg aggacgctgt caccctcatg tgaacggcgt cttctttaat     1140

ggaatcattc tggggcctga cggtaacgtg ctgatcccag agatgcagtc aagcctgctc     1200

cagcagcaca tggagctgct cgaatcctct gtgattcctc tggtccatcc actcgcagat     1260

ccctctacag tgttcaagga cggggatgag gccgaagact ttgtggaggt ccacctgcca     1320

gatgtgcata accaggtgtc tggggtcgac ctcggtctgc ccaattgggg gaagtacgtg     1380

ctgctcagcg ccggtgcact gactgctctc atgctgatca ttttcctgat gacctgctgt     1440

cgacgagtga accggtccga gcctactcag cacaatctgc gagggaccgg tagagaagtg     1500

tccgtcacac cacagtctgg caaaatcatt agttcatggg agagccataa gtccgggggt     1560

gaaacacgcc tgtga                                                      1575


<210>  249
<211>  1575
<212>  DNA
<213>  ArtSeq 	pGP29

<400>  249
atggttcctc aggctctcct gtttgtaccc cttctggttt ttccattgtg ttttgggaaa       60

ttccctattt acacgatacc agacaagctt ggtccctgga gtccgattga catacatcac      120

ctcagctgcc caaacaattt ggtagtggag gacgaaggat gcaccaacct gtcagggttc      180

tcctacatgg aacttaaagt tggatacatc ttagccataa aagtgaacgg gttcacttgc      240

acaggcgttg tgacggaggc tgaaacctac actaacttcg ttggttatgt cacaaccacg      300

ttcaaaagaa agcatttccg cccaacacca gatgcatgta gagccgcgta caactggaag      360

atggccggtg accccagata tgaagagtct ctacacaatc cgtaccctga ctaccgctgg      420

cttcgaactg taaaaaccac caaggagtct ctcgttatca tatctccaag tgtggcagat      480

ttggacccat atgacagatc ccttcactcg agggtcttcc ctagcgggaa gtgctcagga      540

gtagcggtgt cttctaccta ctgctccact aaccacgatt acaccatttg gatgcccgag      600

aatccgagac tagggatgtc ttgtgacatt tttaccaata gtagagggaa gagagcatcc      660

aaagggagtg agacttgcgg ctttgtagat gaaagaggcc tatataagtc tttaaaagga      720

gcatgcaaac tcaagttatg tggagttcta ggacttagac ttatggatgg aacatgggtc      780

tcgatgcaaa catcaaatga aaccaaatgg tgccctcccg ataagttggt gaacctgcac      840

gactttcgct cagacgaaat tgagcacctt gttgtagagg agttggtcag gaagagagag      900

gagtgtctgg atgcactaga gtccatcatg acaaccaagt cagtgagttt cagacgtctc      960

agtcatttaa gaaaacttgt ccctgggttt ggaaaagcat ataccatatt caacaagacc     1020

ttgatggaag ccgatgctca ctacaagtca gtcagaactt ggaatgagat cctcccttca     1080

aaagggtgtt taagagttgg ggggaggtgt catcctcatg tgaacggggt gtttttcaat     1140

ggtataatat taggacctga cggcaatgtc ttaatcccag agatgcaatc atccctcctc     1200

cagcaacata tggagttgtt ggaatcctcg gttatccccc ttgtgcaccc cctggcagac     1260

ccgtctaccg ttttcaagga cggtgacgag gctgaggatt ttgttgaagt tcaccttccc     1320

gatgtgcaca atcaggtctc aggagttgac ttgggtctcc cgaactgggg gaagtatgta     1380

ttactgagtg caggggccct gactgccttg atgttgataa ttttcctgat gacatgttgt     1440

agaagagtca atcgatcaga acctacgcaa cacaatctca gagggacagg gagggaggtg     1500

tcagtcactc cccaaagcgg gaagatcata tcttcatggg aatcacacaa gagtgggggt     1560

gagaccagac tgtaa                                                      1575


<210>  250
<211>  1569
<212>  DNA
<213>  ArtSeq 	pGP30

<400>  250
atgaatatac cttgctttgt tgtgattctc agcttagcca ctacacattc tctgggagaa       60

ttccccttgt acacaattcc tgagaagata gagaaatgga ctcccataga catgatccat      120

ctgagttgcc ccaacaacct attatctgag gaagaaggtt gcaatgcaga gtcatccttt      180

acttactttg agctcaagag tggttaccta gctcatcaga aggttccagg gtttacctgt      240

accggggtcg tgaacgaggc agagacatat acaaacttcg tcgggtacgt caccacaacc      300

ttcaaaagga agcactttag gcctacagta gccgcctgtc gtgatgccta caactggaaa      360

gtgtcaggag accccaggta cgaagagtca ctccacactc cttatcctga cagcagttgg      420

ttgaggactg tgactacaac caaagaatca cttctcataa tatcgcccag catcgtggaa      480

atggatattt acggcaggac tctccattcc cccatgtttc cttcaggagt atgttccaac      540

gtatatccct ctgtcccatc ctgtgagact aatcatgatt acacattatg gctgcctgaa      600

gatcctagtt tgagtttggt ctgtgatatc tttacttcca gcaacggaaa gaaggccatg      660

aacgggtcac gcatctgcgg attcaaggat gaaaggggat tctacagatc tttaaagggc      720

gcttgcaagc tgacattgtg tggaagacct ggaattaggt tattcgacgg aacttgggtc      780

tcttttacaa agccggacgt gcacgtatgg tgcactccca accaattgat caatatacac      840

aatgacagac tagatgagat agaacacctg atcgtggaag acatcataaa gaaaagagaa      900

gagtgcttag acaccctgga aacaatactt atgtctcaat ctgttagctt tagaaggttg      960

agccatttcc gaaagttagt tccaggatat gggaaggcct acactatttt aaacggcagc     1020

ctgatggaaa caaatgtcta ctacaaaagg gtcgacaagt gggctgacat cttaccctct     1080

aagggatgtc tgaaagtcgg gcaacaatgc atggaacctg tcaaaggagt cctcttcaat     1140

gggattatca agggcccgga tggccaaatt ttgatccccg agatgcagtc agagcagcta     1200

aagcagcata tggacctgtt gaaggcggct gtgtttcctc tccgacaccc tttaatcagc     1260

cgggaggcag tctttaagaa agacggggat gccgatgatt ttgtggatct ccatatgcct     1320

gatgtccaca agtctgtgtc agatgtcgac ctgggtctgc ctcattgggg tttctggatg     1380

ttgatcgggg caacaatagt agcatttgtg gtcttggtat gtttactccg tgtatgttgt     1440

aagagagtga ggaggagaag atcaggacgt gcaactcagg agatccccct gagctttccc     1500

tctgcccctg ttcctcgagc caaagtggtg tcatcttggg agtcctataa agggcttcca     1560

ggtacatga                                                             1569


<210>  251
<211>  1653
<212>  DNA
<213>  ArtSeq 	pGP32.1

<400>  251
atggggctta aggccagtgt ctcagcgata ttcatgacgg tgctccttac gctccagacc       60

cctactgggc agatccattg gggcaacctg tcaaaaatag gtgtcgtagg gatcggctcc      120

gcatcatata aggtgatgac gcggtccagt caccagagct tggtgattaa gttgatgcct      180

aacatcactc ttctgaataa ttgtacgcgg gtggaaatcg cggagtatcg cagactcttg      240

cgcacggtac tcgagcctat tagggatgcg cttaacgcaa tgacgcagaa catcaggcct      300

gtacaatcag tagcatccag caggaggcat aaacgattcg cgggggttgt cctcgcgggg      360

gctgctctcg gtgttgccac cgctgcccaa attacggcgg gtatagcgct ccatcaatca      420

atgctgaata gccaggcgat agataacctg agagcgtcct tggagacaac taatcaggca      480

atcgaaacca ttagacaagc cggacaggaa atgattttgg ccgtccaggg aattcaagat      540

tacatcaata atgaattgat tccttcaatg aaccaattga gttgtgatct gattggccaa      600

aaactcggtt tgaaattgct gaggtactac acggagatcc tctctctttt tggcccatcc      660

ctccgcgatc caatttcagc agaaatctca atccaagctc tgagttatgc tctcggcggc      720

gatatcaaca aagtccttga aaagctcggt tatagtggtg gggacctgtt gggcatactc      780

gagtcccgag ggatcaaagc gcgaattact cacgtcgaca ctgaaagtta cttcatcgtt      840

ctgtctattg cttatcccac gttgagtgaa atcaagggag ttatagtcca ccgcttggag      900

ggcgtttcat ataatattgg ttcccaagag tggtacacga cagtgccaaa atacgttgcg      960

acccagggct atctcatcag caactttgac gagtcatctt gtactttcat gccagaagga     1020

acagtttgtt cacagaatgc cctgtatcct atgagcccgt tgctccaaga atgtctcagg     1080

ggatctacta aatcatgtgc gaggactctt gtaagcgggt cctttggaaa tcggtttatt     1140

cttagtcaag gaaatctcat agcgaactgt gcgagtattt tgtgtaaatg ttacacgacc     1200

ggtacgatca taaatcaaga cccagacaag attctgacct atattgctgc agactattgc     1260

cccgtggtag aggtaaatgg ggtgactata caggttgggt cacgcaaata tcccgatgcc     1320

gtgtacttgc acaggataga tttgggccct cctattagcc tcgaacgcct ggacgtaggg     1380

acgaacctgg gaaatgcggt cgctaagctc gaagacgcaa aagagctgct cgaatcatcc     1440

gatcagatac tgcggagtat gaagggtctg agttccacaa acattgttta cattcttatt     1500

gccgtttgct tggggggtct gattggcata cccactttga tttgttgttg ccgaggtcgc     1560

tgcaacaaaa aaggggggca ggtcggcatg agtcgaccgg gccttaagcc agacttgaca     1620

ggtacgagta aaagttacgt tcgctccctt tag                                  1653


<210>  252
<211>  1854
<212>  DNA
<213>  ArtSeq 	pGP32.2

<400>  252
atgtcaccac aacgagaccg gataaatgcc ttctacaaag ataaccccca tcccaaggga       60

agtaggatag ttattaatag agaacatctt atgattgata gaccttatgt tttgctggct      120

gttctattcg tcatgtttct gagcttgatc gggttgctag ccattgcagg catcagactt      180

catcgggcag ccatctacac cgcagagatc cataaaagcc tcagcaccaa tctagatgta      240

actaactcaa tcgagcatca ggtcaaggac gtgctgacac cactcttcaa aatcatcggt      300

gatgaagtgg gcctgagaac acctcagaga ttcactgacc tagtgaaatt catctctgac      360

aagattaaat tcctcaatcc ggatagggag tacgacttca gagatctcac ttggtgtatc      420

aacccgccag agagaatcaa attggactat gatcaatact gtgcagatgt ggctgctgaa      480

gagctcatga atgcattggt gaactcaact ctactggaga ctaggacaac caatcagttc      540

ctagctgtct caaagggaaa ctgctcaggg cccactacaa tcagaggtca attctcaaac      600

atgtcgttgt ccctgttgga cttgtatttg agtcgaggtt acaatgtgtc atctatagtc      660

actatgacat cccagggaat gtacggggga acttacctag tggaaaagcc taatctgagc      720

agcaaagggt cagagttgcc acaaccaagc atgcaccgag tgtttgaagt aggtgtcatc      780

agaaatccgg gtttgggggc tccggtgttc catatgacaa actattttga gcagccagtc      840

agcaatgatt tcagcaactg tatggtggct ttgggggagc tcaaactcgc agctctttgc      900

cacggggaag attctatcac aattccctat cagggatcag ggaaaggtgt cagcttccag      960

ctcgtcaagc taggtgtctg gaaatcccca accgacatgc aatcctgggt ccccttatca     1020

acggatgatc cagtgataga caggctttac ctctcatctc acagaggtat tatcgctgac     1080

aatcaagcaa aatgggctgt cccgacaaca cgaacagatg acaagttgcg aatggagaca     1140

tgcttccagc aggcgtgtaa gggtaaaatc caagcactct gcgagaatcc cgagtgggca     1200

ccattgaagg ataacaggat tccttcatac ggggtcttgt ctgttgatct gagcctggca     1260

gttgagctta aaatcaaaat tgcttcagga ttcgggccat tgatcacaca cggttcaggg     1320

atggacctat acaaatccaa ccacaacaat gtgtattggc tgactatccc gccaatgaag     1380

aacctagcct taggtgtaat caacacattg gagtggatac cgagattcaa ggttagtccc     1440

aacctcttta ctgtcccaat taaggaagca ggcgaggact gccatgcccc gacataccta     1500

cctgcggagg tggatggtga tgtcaaactc agttccaatc tggtgattct acctggtcaa     1560

gatctccaat atgttttggc aacctacgat acttccaggg ttgaacatgc tgtggtttat     1620

tacgtttaca gcccaagccg ctcattttct tacttttatc cttttaggtt gcctataaag     1680

ggagtcccca tcgaattaca agtggaatgc ttcacatggg accaaaaact ctggtgccgt     1740

cacttctgtg tgcttgcaga ctcagaatct ggtggacata tcactcactc tgggatggtg     1800

ggtatgggag tcagctgcac agtcactcgg gaagatggaa ccaaccgcgg atag           1854


<210>  253
<211>  1467
<212>  DNA
<213>  ArtSeq 	pGP6

<400>  253
atgggtaagt ttctcgccac tttgatttta ttcttccagt tctgccccct catcttcggt       60

gattacagcc ccagctgctg tactctcaca attggagtct cctcatacca ctctaaaccc      120

tgcaatcctg cccagccagt ttgttcgtgg accctcgacc tgctggccct ttcagcagat      180

caggccctac agcccccctg ccctaaccta gtaagttact ccagctacca tgccacctat      240

tccctatatc tattccctca ttggactaag aagccaaacc gaaatggcgg aggctattat      300

tcagcctctt attcagaccc ttgttcctta aagtgcccat acctggggtg ccaatcatgg      360

acctgcccct atacaggagc cgtctccagc ccctactgga agtttcaaca cgatgtcaat      420

tttactcaag aagtttcacg cctcaatatt aatctccatt tttcaaaatg cggttttccc      480

ttctcccttc tagtcgacgc tccaggatat gaccccatct ggttccttaa taccgaaccc      540

agccaactgc ctcccaccgc ccctcctcta ctcccccact ctaacctaga ccacatcctc      600

gagccctcta taccatggaa atcaaaactc ctgacccttg tccagttaac cctacaaagc      660

actaattata cttgcattgt ctgtatcgat cgtgccagcc tctccacttg gcacgtccta      720

tactctccca acgtctctgt tccatcctct tcttctaccc ccctccttta cccatcgtta      780

gcgcttccag ccccccacct gacgttacca tttaactgga cccactgctt tgacccccag      840

attcaagcta tagtctcctc cccctgtcat aactccctca tcctgccccc cttttccttg      900

tcacctgttc ccaccctagg atcccgctcc cgccgagcgg taccggtggc ggtctggctt      960

gtctccgccc tggccatggg agccggagtg gctggcggga ttaccggctc catgtccctc     1020

gcctcaggaa agagcctcct acatgaggtg gacaaagata tttcccagtt aactcaagca     1080

atagtcaaaa accacaaaaa tctactcaaa attgcgcagt atgctgccca gaacagacga     1140

ggccttgatc tcctgttctg ggagcaagga ggattatgca aagcattaca agaacagtgc     1200

cgttttccga atattaccaa ttcccatgtc ccaatactac aagaaagacc cccccttgag     1260

aatcgagtcc tgactggctg gggccttaac tgggaccttg gcctctcaca gtgggctcga     1320

gaggccttac aaactggaat cacccttgtt gcgctactcc ttcttgttat ccttgcagga     1380

ccatgcatcc tccgtcagct acgacacctc ccctcgcgcg tcagataccc ccattactct     1440

cttataaaac ctgagtcatc cctgtaa                                         1467


<210>  254
<211>  1467
<212>  DNA
<213>  ArtSeq 	pGP7

<400>  254
atgggtaagt ttctcgccac tttgatttta ttcttccagt tctgccccct catcttcggt       60

gattacagcc ccagctgctg tactctcaca attggagtct cctcatacca ctctaaaccc      120

tgcaatcctg cccagccagt ttgttcgtgg accctcgacc tgctggccct ttcagcagat      180

caggccctac agcccccctg ccctaaccta gtaagttact ccagctacca tgccacctat      240

tccctatatc tattccctca ttggactaag aagccaaacc gaaatggcgg aggctattat      300

tcagcctctt attcagaccc ttgttcctta aagtgcccat acctggggtg ccaatcatgg      360

acctgcccct atacaggagc cgtctccagc ccctactgga agtttcaaca cgatgtcaat      420

tttactcaag aagtttcacg cctcaatatt aatctccatt tttcaaaatg cggttttccc      480

ttctcccttc tagtcgacgc tccaggatat gaccccatct ggttccttaa taccgaaccc      540

agccaactgc ctcccaccgc ccctcctcta ctcccccact ctaacctaga ccacatcctc      600

gagccctcta taccatggaa atcaaaactc ctgacccttg tccagttaac cctacaaagc      660

actaattata cttgcattgt ctgtatcgat cgtgccagcc tctccacttg gcacgtccta      720

tactctccca acgtctctgt tccatcctct tcttctaccc ccctccttta cccatcgtta      780

gcgcttccag ccccccacct gacgttacca tttaactgga cccactgctt tgacccccag      840

attcaagcta tagtctcctc cccctgtcat aactccctca tcctgccccc cttttccttg      900

tcacctgttc ccaccctagg atcccgctcc cgccgagcgg taccggtggc ggtctggctt      960

gtctccgccc tggccatggg agccggagtg gctggcggga ttaccggctc catgtccctc     1020

gcctcaggaa agagcctcct acatgaggtg gacaaagata tttcccagtt aactcaagca     1080

atagtcaaaa accacaaaaa tctactcaaa attgcgcagt atgctgccca gaacagacga     1140

ggccttgatc tcctgttctg ggagcaagga ggattatgca aagcattaca agaacagtgc     1200

cgttttccga atattaccaa ttcccatgtc ccaatactac aagaaagacc cccccttgag     1260

aatcgagtcc tgactggctg gggccttaac tgggaccttg gcctctcaca gtgggctcga     1320

gaggccttac aaactggaat cacccttgtt gcgctactcc ttcttgttat ccttgcagga     1380

ccatgcatcc tccgtcagct acgacacctc ccctcgcgcg tcagataccc ccattactct     1440

cttataaaac ctgagtcatc cctgtaa                                         1467


<210>  255
<211>  1698
<212>  DNA
<213>  ArtSeq 	pGP8

<400>  255
atgaaactcc caacaggaat ggtcatttta tgtagcctaa taatagttcg ggcagggttt       60

gacgaccccc gcaaggctat cgcattagta caaaaacaac atggtaaacc atgcgaatgc      120

agcggagggc aggtatccga ggccccaccg aactccatcc aacaggtaac ttgcccaggc      180

aagacggcct acttaatgac caaccaaaaa tggaaatgca gagtcactcc aaaaaatctc      240

acccctagcg ggggagaact ccagaactgc ccctgtaaca ctttccagga ctcgatgcac      300

agttcttgtt atactgaata ccggcaatgc agggcgaata ataagacata ctacacggcc      360

accttgctta aaatacggtc tgggagcctc aacgaggtac agatattaca aaaccccaat      420

cagctcctac agtccccttg taggggctct ataaatcagc ccgtttgctg gagtgccaca      480

gcccccatcc atatctccga tggtggagga cccctcgata ctaagagagt gtggacagtc      540

caaaaaaggc tagaacaaat tcataaggct atgcatcctg aacttcaata ccacccctta      600

gccctgccca aagtcagaga tgaccttagc cttgatgcac ggacttttga tatcctgaat      660

accactttta ggttactcca gatgtccaat tttagccttg cccaagattg ttggctctgt      720

ttaaaactag gtacccctac ccctcttgcg atacccactc cctctttaac ctactcccta      780

gcagactccc tagcgaatgc ctcctgtcag attatacctc ccctcttggt tcaaccgatg      840

cagttctcca actcgtcctg tttatcttcc cctttcatta acgatacgga acaaatagac      900

ttaggtgcag tcacctttac taactgcacc tctgtagcca atgtcagtag tcctttatgt      960

gccctaaacg ggtcagtctt cctctgtgga aataacatgg catacaccta tttaccccaa     1020

aactggacag gactttgcgt ccaagcctcc ctcctccccg acattgacat catcccgggg     1080

gatgagccag tccccattcc tgccattgat cattatatac atagacctaa acgagctgta     1140

cagttcatcc ctttactagc tggactggga atcaccgcag cattcaccac cggagctaca     1200

ggcctaggtg tctccgtcac ccagtataca aaattatccc atcagttaat atctgatgtc     1260

caagtcttat ccggtaccat acaagattta caagaccagg tagactcgtt agctgaagta     1320

gttctccaaa ataggagggg actggaccta ctaacggcag aacaaggagg aatttgttta     1380

gccttacaag aaaaatgctg tttttatgct aacaagtcag gaattgtgag aaacaaaata     1440

agaaccctac aagaagaatt acaaaaacgc agggaaagcc tggcatccaa ccctctctgg     1500

accgggctgc agggctttct tccgtacctc ctacctctcc tgggacccct actcaccctc     1560

ctactcatac taaccattgg gccatgcgtt ttcagtcgcc tcatggcctt cattaatgat     1620

agacttaatg ttgtacatgc catggtgctg gcccagcaat accaagcact caaagctgag     1680

gaagaagctc aggattga                                                   1698


<210>  256
<211>  2058
<212>  DNA
<213>  ArtSeq 	pGP9

<400>  256
atggtattgc tgcctgggtc catgcttctc acctcaagcc tgcaccacct tcggcaccag       60

atgagtcctg ggagttggaa aagactgatc atcctcttaa gctgcgtatt cggcggcggc      120

ggaacgagtc tgcaaaataa gaacccccac cagcctatga ccctcacctg gcaggtactg      180

tcccaaactg gagacgttgt ctgggataca aaggcagtcc agcccccttg gacttggtgg      240

cccacactta aacctgatat atgtgccttg gcggctggtc ttgagtcctg ggatatcccg      300

ggaaccgatg tctcgtcctc taaacgagtc agacctccgg actcagacta tactgccgct      360

tataaacaaa tcacctgggg agccataggg tgcagctacc ctcgggctag gaccagaatg      420

gcaagctcca ccttctacgt atgtccccgg gatggccgga ccccttcaga agctagaagg      480

tgcggggggc tagaatccct atactgtaaa gaatggaatt gtgaaaccac agggaccggt      540

tattggctac ccaagtcctc aaaagacctc ataacgggta gatgggatca aaatagcaaa      600

tgggatcaaa aatttcaaaa gtgtcaccag accggctggt gtaaccccct taaaatagat      660

ttcacagaca caggaaaatc ctccagggat tggatagtag gaaaaacctg gggattaaga      720

ttctatgtgc atggacatcc aggcgtccag ttcaccattc gcttaaaaat caccagcatg      780

acagctgtgg cagtcggccc cgatcccgtc cttgtggaac aaggacctcc cagaagggcc      840

ctcgctctcc cacctcctct ccccccaagg gaagcgccac cgccacctct ccccgactcc      900

aactccacaa ccctggcgac tagtgcacaa actcccacgg tgggaaaaac aattgttacc      960

ctaaacactc cgcctcccac cacaggcgac agactcttta acctcgtgca gggggccttc     1020

ctaaccctga atgctaccaa cccaggggcc actaagtcat gctggctttg tttggccatg     1080

ggtcccccct attatgaagc aataacctca ttgggggagg tcgcttattc caccagccag     1140

gaccggtgcc actggggaac ccaaggaaag cttaccctca ctgaggtctc aggacacggg     1200

ttatgcatag gaaaggtgcc cttcacccat cagcatctct gcaatcagac cctatccatc     1260

aattcctccg agggccatca gtatctgctc ccctccaatc atagctggtg ggcttgcagc     1320

actggcctca ccccttgcct ctctacctca gtttttaatc agagtcgaga tttctgtatc     1380

caggtccagc tgatccctcg catctattac tatcctgaag aagttttgtt acaggcctat     1440

gacgattctc accccaggcc taaaagagaa gctgtctcac ttaccctagc tgttttactg     1500

gggttgggga tcacggcggg tataggtact ggttcaaccg ccttaattaa aggacccata     1560

gacctccaac aaggcctgac cagcctccag atcgccatag atgctgacct ccgggccctc     1620

caggactcag tcagcaagct ggaggactca ctgacctccc tgtccgaggt agtactccaa     1680

aataggagag gccttgactt gctgtttcta aaggaaggag gcctctgtgc ggccctaaaa     1740

gaagagtgct gtttttatat agaccactca ggtgcagtac gagactccat gaaaaaactc     1800

aaagaaaaac tagataaaag acagttagag cgccagaaaa accaaaactg gtatgaaggg     1860

tggttcaata actccccttg gttcactacc ctactatcaa ccattgccgg gcccctgtta     1920

ctcctccttc tattgctcat cctcgggccc tgcatcatca ataagttagt tcaattcatc     1980

aatgatagag taagtgcagt taaaattttg gtccttagga caaaatatca ggccctagat     2040

aacgaagata acctttaa                                                   2058


<210>  257
<211>  1998
<212>  DNA
<213>  ArtSeq 	pGP10

<400>  257
atggcgcgtt caacgctctc aaaacccctt aaaaataagg ttaacccgcg aggcccccta       60

atccccttaa ttcttctgat gctcagaggg gtcagtactg cttcgcccgg ctccagtcct      120

catcaagtct ataatatcac ctgggaggta accaatggag atcgggagac ggtatgggca      180

acttctggca accaccctct gtggacctgg tggcctgacc ttaccccaga tttatgtatg      240

ttagcccacc atggaccatc ttattggggg ctagaatatc aatccccttt ttcttctccc      300

ccggggcccc cttgttgctc agggggcagc agcccaggct gttccagaga ctgcgaagaa      360

cctttaacct ccctcacccc tcggtgcaac actgcctgga acagactcaa gctagaccag      420

acaactcata aatcaaatga gggattttat gtttgccccg ggccccaccg cccccgagaa      480

tccaagtcat gtgggggtcc agactccttc tactgtgcct attggggctg tgagacaacc      540

ggtagagctt actggaagcc ctcctcatca tgggatttca tcacagtaaa caacaatctc      600

acctctgacc aggctgtcca ggtatgcaaa gataataagt ggtgcaaccc cttagttatt      660

cggtttacag acgccgggag acgggttact tcctggacca caggacatta ctggggctta      720

cgtttgtatg tctccggaca agatccaggg cttacatttg ggatccgact cagataccaa      780

aatctaggac cccgcgtccc aatagggcca aaccccgttc tggcagacca acagccactc      840

tccaagccca aacctgttaa gtcgccttca gtcaccaaac cacccagtgg gactcctctc      900

tcccctaccc aacttccacc ggcgggaacg gaaaataggc tgctaaactt agtagacgga      960

gcctaccaag ccctcaacct caccagtcct gacaaaaccc aagagtgctg gttgtgtcta     1020

gtagcgggac ccccctacta cgaaggggtt gccgtcctgg gtacctactc caaccatacc     1080

tctgctccag ccaactgctc cgtggcctcc caacacaagt tgaccctgtc cgaagtgacc     1140

ggacagggac tctgcatagg agcagttccc aaaacacatc aggccctatg taataccacc     1200

cagacaagca gtcgagggtc ctattatcta gttgccccta caggtaccat gtgggcttgt     1260

agtaccgggc ttactccatg catctccacc accatactga accttaccac tgattattgt     1320

gttcttgtcg aactctggcc aagagtcacc tatcattccc ccagctatgt ttacggcctg     1380

tttgagagat ccaaccgaca caaaagagaa ccggtgtcgt taaccctggc cctattattg     1440

ggtggactaa ccatgggggg aattgccgct ggaataggaa cagggactac tgctctaatg     1500

gccactcagc aattccagca gctccaagcc gcagtacagg atgatctcag ggaggttgaa     1560

aaatcaatct ctaacctaga aaagtctctc acttccctgt ctgaagttgt cctacagaat     1620

cgaaggggcc tagacttgtt atttctaaaa gaaggagggc tgtgtgctgc tctaaaagaa     1680

gaatgttgct tctatgcgga ccacacagga ctagtgagag acagcatggc caaattgaga     1740

gagaggctta atcagagaca gaaactgttt gagtcaactc aaggatggtt tgagggactg     1800

tttaacagat ccccttggtt taccaccttg atatctacca ttatgggacc cctcattgta     1860

ctcctaatga ttttgctctt cggaccctgc attcttaatc gattagtcca atttgttaaa     1920

gacaggatat cagtggtcca ggctctagtt ttgactcaac aatatcacca gctgaagcct     1980

atagagtacg agccatag                                                   1998


<210>  258
<211>  1692
<212>  DNA
<213>  ArtSeq 	pGP11

<400>  258
atgggattca caacaaagat aatcttctta tacaacctag tactggtcta cgcggggttt       60

gacgaccctc gcaaagccat agaactagta caaaagcgat atggccgacc atgcgattgc      120

agcggaggac aagtgtccga gcccccgtca gacagggtca gtcaagtgac ttgctcaggc      180

aagacagctt acttaatgcc cgaccaaaga tggaaatgta agtcaattcc aaaagacacc      240

tccccaagcg ggccactcca agagtgcccc tgtaattctt accagtcctc agtacacagt      300

tcttgttata cctcatacca acaatgcaga tcaggcaata agacatatta tacggctact      360

ctgctaaaaa cacaaactgg gggcaccagt gatgtacaag tattaggatc caccaacaaa      420

cttatacaat ctccctgtaa tggcataaaa gggcagtcta tttgctggag cactacagct      480

cctatccacg tctctgatgg aggaggtcca ttagacacca caagaattaa aagtgttcag      540

agaaaactgg aagaaattca taaagcccta tatcctgaac ttcagtatca ccctttggcc      600

atacctaagg ttagagataa cctcatggtc gatgcccaga ctttaaacat tctcaatgcc      660

acttacaact tactcctaat gtccaacacg agcctagtgg acgactgttg gctttgttta      720

aaattaggtc cccctactcc cctcgcaata cctaacttcc tattatccta cgtgactcgc      780

tcctcggata atatctcttg tttaataatt cccccccttc tagttcaacc gatgcagttt      840

tccaattcat cttgcctctt ttccccctcc tacaacagta cagaagaaat agatctaggc      900

catgttgcct tcagcaactg tacctccata accaatgtca ccggtcccat atgcgctgta      960

aatggttcgg tctttctctg tggcaataac atggcataca cttatctacc cacgaactgg     1020

acggggcttt gcgtcctagc aactctcctc cccgacattg acatcattcc cggagatgaa     1080

ccggtcccca tccctgctat tgatcatttt atatatagac ctaaacgggc catacagttt     1140

attcctttac tagcagggct agggatcacc gcagccttca caacaggagc tacaggccta     1200

ggtgtctctg tgacccaata tacaaaatta tctaatcagc taatttctga tgtacaaatc     1260

ttatctagca ccatacaaga tctgcaagat caagtagact cattagccga agtggttctc     1320

cagaacagaa gggggctaga tctacttaca gcagaacaag gaggaatctg tttagccctg     1380

caagaaaaat gctgctttta tgttaacaag tcagggattg tgagagacaa aataaaaacc     1440

ttacaagaag aactagaaag acgtagaaaa gatctagctt ccaacccact ttggactggg     1500

cttcaagggc tcctccctta cctcctgccc tttcttggcc ctctacttac cctcctgctc     1560

ttactcacca ttgggccgtg catttttaac cgtctaaccg cttttattaa tgataagtta     1620

aacataatac acgctatggt gctaacccaa cagtatcagg tgctcagaac cgatgaagaa     1680

gctcaagatt ga                                                         1692


<210>  259
<211>  2958
<212>  DNA
<213>  ArtSeq 	pGP12

<400>  259
atgacactgc aacaatggat catttggaaa aaaatgaata aagcgcatga ggcacttcaa       60

aatacaacaa ctgtgactga acagcagaag gaacaaatta tactggacat tcaaaatgaa      120

gaagtacaac caactaggag agataaattt agatatctgc tttatacttg ttgtgctact      180

agctcaagag tattggcctg gatgttttta gtttgtatat tgttaatcat tgttttggtt      240

tcatgctttg tgactatatc cagaatacaa tggaataagg atattcaggt attaggacct      300

gtaatagact ggaatgttac tcaaagagct gtttatcaac ccttacagac tagaaggatt      360

gcacgttccc ttagaatgca gcatcctgtt ccaaaatatg tggaggtaaa tatgactagt      420

attccacaag gtgtatacta tgaaccccat ccggaaccca tagtggtgaa ggagagggtc      480

ctaggtcttt ctcaaattct gatgattaat tcagaaaaca ttgctaataa tgctaatttg      540

acacaagaag taaagaagtt gttaactgaa atggttaatg aagaaatgca aagtttgtca      600

gatgtaatga ttgactttga aattccttta ggagaccctc gtgatcaaga acaatatata      660

catagaaaat gctatcaaga atttgcaaat tgttatttag taaaatataa agaacccaaa      720

ccgtggccta aggagggcct tatagctgat caatgcccat taccaggtta ccatgctgga      780

ttaacctata atagacagtc tatttgggat tactatatta aagtggagag tattagacct      840

gcaaattgga caacaaagag taaatatgga caagctagac taggaagttt ttatattcct      900

agcagcctga gacaaatcaa tgttagtcat gtactattct gtagtgatca attatattct      960

aaatggtata atatagaaaa taccatagaa caaaacgagc ggtttctgct taataaacta     1020

aataacctta catctggaac ctcagtattg aagaaaagag ctcttccgaa ggattggagt     1080

tctcaaggta aaaatgctct gtttagagaa atcaatgtgt tagatatctg cagtaaacct     1140

gaatctgtaa tactattgaa tacttcatac tattccttct ctttatggga aggagattgt     1200

aattttacta aagatatgat ttctcagttg gttccagaat gtgatggatt ttataacaat     1260

tctaagtgga tgcatatgca tccatatgct tgtagattct ggagaagtaa gaagaatgaa     1320

aaagaagaaa ctaaatgtag agatggggaa actaagagat gtctgtatta tcctttatgg     1380

gacagtcccg aatctacata tgattttggt tatttagcat accaaaagaa ttttccttcc     1440

cctatctgta tagaacaaca gaaaattaga gatcaagatt atgaagtcta ttctttgtat     1500

caagaacgca aaatagcttc taaagcatat ggaattgata cagttttatt ctctctaaag     1560

aattttctta attatacagg aactcctgta aatgaaatgc ctaatgcaag agcttttgta     1620

ggcctaatag atcccaagtt tcctccttcc tatcccaatg ttactaggga acattatact     1680

tcctgtaata ataggaaaag aagaagtgtt gataataact atgctaagtt aaggtctatg     1740

gggtatgcac ttacaggagc agtgcaaacc ttatctcaaa tatcagatat taatgatgaa     1800

aacttacagc aaggaatata tttattaagg gatcatgtaa taaccttaat ggaagctaca     1860

ttgcatgata tatctgttat ggaaggaatg tttgctgtac aacatttgca tacacatttg     1920

aatcatttga agacaatgct tctagaaaga agaatagact ggacctatat gtctagtact     1980

tggctacaac aacaattaca gaaatctgat gatgagatga aagtaataaa gagaattgct     2040

agaagtttgg tatattatgt taaacaaacc catagttctc ccacagctac agcctgggag     2100

attggattat attatgaatt ggttatacct aaacatattt acttgaataa ttggaatgtt     2160

gtcaatatag gtcacttagt taaatcagct ggacaattga ctcatgtaac tatagctcat     2220

ccttatgaaa taatcaataa ggaatgtgta gagactatat atctgcatct tgaggactgc     2280

acaagacaag attatgtcat atgtgatgtg gtaaagatag tgcagccttg tggcaatagc     2340

tcagacacga gtgattgtcc tgtctgggct gaagctgtaa aagaaccatt tgtgcaagtc     2400

aatcctctga aaaacggaag ttatctggtt ttggcaagtt ccacagactg tcagatccca     2460

ccatatgttc ctagcatcgt gactgttaat gaaacaacgt catgctttgg actggacttt     2520

aaaaggccac tggttgcgga agaaagattg agctttgagc cacgactgcc aaatctacaa     2580

ctaagattac cacatttggt tggaattatt gcaaaaatca aagggataaa aatagaagtc     2640

acatcctctg gagaaagtat aaaagagcag attgaaagag caaaagctga gctccttcga     2700

ctggacattc acgagggaga tactcctgcc tggatacaac agctagctgc agcaacaaag     2760

gacgtctggc cagcagcagc ttctgctcta caaggaattg gtaacttttt atctgggact     2820

gcccaaggaa tatttggaac tgcctttagt ctcttgggat acttaaagcc tatcctaata     2880

ggagtagggg tcattctctt ggttattctt atatttaaga ttgtatcatg gattcctacg     2940

aaaaagaaga atcagtag                                                   2958


<210>  260
<211>  2031
<212>  DNA
<213>  ArtSeq 	pGP41

<400>  260
atgggcgtta caggaatatt gcagttacct cgtgatcgat tcaagaggac atcattcttt       60

ctttgggtaa ttatcctttt ccaaagaaca ttttccatcc cacttggagt catccacaat      120

agcacattac aggttagtga tgtcgacaaa ctagtttgtc gtgacaaact gtcatccaca      180

aatcaattga gatcagttgg actgaatctc gaagggaatg gagtggcaac tgacgtgcca      240

tctgcaacta aaagatgggg cttcaggtcc ggtgtcccac caaaggtggt caattatgaa      300

gctggtgaat gggctgaaaa ctgctacaat cttgaaatca aaaaacctga cgggagtgag      360

tgtctaccag cagcgccaga cgggattcgg ggcttccccc ggtgccggta tgtgcacaaa      420

gtatcaggaa cgggaccgtg tgccggagac tttgccttcc ataaagaggg tgctttcttc      480

ctgtatgatc gacttgcttc cacagttatc taccgaggaa cgactttcgc tgaaggtgtc      540

gttgcatttc tgatactgcc ccaagctaag aaggacttct tcagctcaca ccccttgaga      600

gagccggtca atgcaacgga ggacccgtct agtggctact attctaccac aattagatat      660

caggctaccg gttttggaac caatgagaca gagtacttgt tcgaggttga caatttgacc      720

tacgtccaac ttgaatcaag attcacacca cagtttctgc tccagctgaa tgagacaata      780

tatacaagtg ggaaaaggag caataccacg ggaaaactaa tttggaaggt caaccccgaa      840

attgatacaa caatcgggga gtgggccttc tgggaaacta aaaaaaacct cactagaaaa      900

attcgcagtg aagagttgtc tttcacagtt gtatcaaacg gagccaaaaa catcagtggt      960

cagagtccgg cgcgaacttc ttccgaccca gggaccaaca caacaactga agaccacaaa     1020

atcatggctt cagaaaattc ctctgcaatg gttcaagtgc acagtcaagg aagggaagct     1080

gcagtgtcgc atctaacaac ccttgccaca atctccacga gtccccaatc cctcacaacc     1140

aaaccaggtc cggacaacag cacccataat acacccgtgt ataaacttga catctctgag     1200

gcaactcaag ttgaacaaca tcaccgcaga acagacaacg acagcacagc ctccgacact     1260

ccctctgcca cgaccgcagc cggaccccca aaagcagaga acaccaacac gagcaagagc     1320

actgacttcc tggaccccgc caccacaaca agtccccaaa accacagcga gaccgctggc     1380

aacaacaaca ctcatcacca agataccgga gaagagagtg ccagcagcgg gaagctaggc     1440

ttaattacca atactattgc tggagtcgca ggactgatca caggcgggag aagaactcga     1500

agagaagcaa ttgtcaatgc tcaacccaaa tgcaacccta atttacatta ctggactact     1560

caggatgaag gtgctgcaat cggactggcc tggataccat atttcgggcc agcagccgag     1620

ggaatttaca tagaggggct aatgcacaat caagatggtt taatctgtgg gttgagacag     1680

ctggccaacg agacgactca agctcttcaa ctgttcctga gagccacaac tgagctacgc     1740

accttttcaa tcctcaaccg taaggcaatt gatttcttgc tgcagcgatg gggcggcaca     1800

tgccacattc tgggaccgga ctgctgtatc gaaccacatg attggaccaa gaacataaca     1860

gacaaaattg atcagattat tcatgatttt gttgataaaa cccttccgga ccagggggac     1920

aatgacaatt ggtggacagg atggagacaa tggataccgg caggtattgg agttacaggc     1980

gttataattg cagttatcgc tttattctgt atatgcaaat ttgtctttta g              2031


<210>  261
<211>  1485
<212>  DNA
<213>  ArtSeq 	pGP25

<400>  261
atgcggtgcg tgggaatagg aaacagagac ttcgtggaag gactgtcagg agctacgtgg       60

gtggatgtag ttctggagca tggaagttgc gtcactacca tggcaaaaga caaaccaaca      120

ctggacattg aactcctgaa gacggaggtc acaaaccctg ccgtcctgcg caaactgtgt      180

atagaagcta aaatatcaaa taccaccact gactcgagat gtccgacaca aggagaagcc      240

acgctggtgg aagaacaaga cacgaacttt gtgtgtcgac gaacattcgt ggacagaggc      300

tggggcaatg gttgtggact attcggaaag ggtagcttaa taacgtgtgc taagtttaag      360

tgtgtgacaa aattggaagg aaagatagtc caatatgaaa acttaaaata ttctgtgatc      420

gttaccgtcc acactggaga ccagcaccaa gttggaaatg agaccacaga acatggaaca      480

attgcaacca taacacctca agctcccacg tcggaaatac aactgacaga ctacggagct      540

ctaacactgg attgttcacc tagaacaggg ctagacttta atgagatggt gttgctgaca      600

atgaaagaaa aatcatggct cgtccacaaa caatggtttc tagacttacc actgccttgg      660

acctcagggg cctcaacgtc ccaagagact tggaacagac aagacttgct ggtcacgttt      720

aagacagctc atgcaaagaa gcaggaagta gtcgtactag gatcacaaga aggagcaatg      780

cacactgcgt tgactggagc gacagaaatc caaacgtctg gaacgacaac aatttttgca      840

ggccacctga aatgcagatt aaaaatggac aaactaactc taaaaggaat atcatatgta      900

atgtgcacag gctcattcaa gttagagaag gaagtggctg agacccagca tggaactgtt      960

ctagtacagg tcaaatacga aggaacagat gcaccatgca agatcccctt ctcgtcccaa     1020

gatgagaagg gagtaaccca gaatgggaga ttggtaacag ccaaccccat agtcactgac     1080

aaagaaaaac cagtcaacat tgaagcggag ccaccctttg gtgagagcta catcgtggta     1140

ggagcaggtg aaaaagcttt gaaactaagc tggttcaaga agggaagcag tatagggaaa     1200

atgtttgaag caactgcccg tggagcacga aggatggcca tcctgggaga caccgcatgg     1260

gacttcggct ctataggagg agtgttcacg tctgtgggaa aactggtaca ccagatcttt     1320

ggaactgcgt atggagtttt gttcagcggt gtttcttgga ccatgaaaat aggaataggg     1380

attctgctga catggctggg attaaactca aggagcacgt ccctttcaat gacgtgtatc     1440

gcagttggca tggtcacact gtacctagga gtcatggtcc aggcg                     1485


<210>  262
<211>  1518
<212>  DNA
<213>  ArtSeq 	pGP26

<400>  262
atgatcaggt gcataggagt cagcaatagg gactttgtgg aaggtatgtc aggtgggact       60

tgggttgatg ttgtcttgga acatggaggt tgtgtcaccg taatggcaca ggacaaaccg      120

actgtcgaca tagagctggt tacaacaaca gtcagcaaca tggcggaggt aagatcctac      180

tgctatgagg catcaatatc agacatggct tcggacagcc gctgcccaac acaaggtgaa      240

gcctaccttg acaagcaatc agacactcaa tatgtctgca aaagaacgtt agtggacaga      300

ggctggggaa atggatgtgg actttttggc aaagggagcc tggtgacatg cgctaagttt      360

gcatgctcca agaaaatgac cgggaagagc atccagccag agaatctgga gtaccggata      420

atgctgtcag ttcatggctc ccagcacagt gggatgatcg ttaatgacac aggacatgaa      480

actgatgaga atagagcgaa ggttgagata acgcccaatt caccaagagc cgaagccacc      540

ctggggggtt ttggaagcct aggacttgat tgtgaaccga ggacaggcct tgacttttca      600

gatttgtatt acttgactat gaataacaag cactggttgg tccacaagga gtggttccac      660

gacattccat taccttggca cgctggggca gacaccggaa ctccacactg gaacaacaaa      720

gaagcactgg tagagttcaa ggacgcacat gccaaaaggc aaactgtcgt ggttctaggg      780

agtcaagaag gagcagttca cacggccctt gctggagctc tggaggctga gatggatggt      840

gcaaagggaa ggctgtcctc tggccacttg aaatgtcgcc tgaaaatgga taaacttaga      900

ttgaagggcg tgtcatactc cttgtgtacc gcagcgttca cattcaccaa gatcccggct      960

gaaacactgc acgggacagt cacagtggag gtacagtacg cagggacaga tggaccttgc     1020

aaggttccag ctcagatggc ggtggacatg caaactctga ccccagttgg gaggttgata     1080

accgctaacc ccgtaatcac tgaaagcact gagaactcta agatgatgct ggaacttgat     1140

ccaccatttg gggactctta cattgtcata ggagtcgggg agaagaagat cacccaccac     1200

tggcacagga gtggcagcac cattggaaaa gcatttgaag ccactgtgag aggtgccaag     1260

agaatggcag tcttgggaga cacagcctgg gactttggat cagttggagg cgctctcaac     1320

tcattgggca agggcatcca tcaaattttt ggagcagctt tcaaatcatt gtttggagga     1380

atgtcctggt tctcacaaat cctcattgga acgttgctga tgtggttggg tctgaacaca     1440

aagaatggat ctatttccct tatgtgcttg gccttagggg gagtgttgat cttcttatcc     1500

acagccgtct ctgcttag                                                   1518


<210>  263
<211>  1284
<212>  DNA
<213>  ArtSeq 	pGP27

<400>  263
atgttcaact gccttggaat gagcaacaga gacttcttgg aaggagtgtc tggagcaaca       60

tgggtggatt tggttctcga aggcgacagc tgcgtgacta tcatgtctaa ggacaagcct      120

accatcgatg tgaagatgat gaatatggag gcggccaacc tggcagaggt ccgcagttat      180

tgctatttgg ctaccgtcag cgatctctcc accaaagctg cgtgcccgac catgggagaa      240

gctcacaatg acaaacgtgc tgacccagct tttgtgtgca gacaaggagt ggtggacagg      300

ggctggggca acggctgcgg actatttggc aaaggaagca ttgacacatg cgccaaattt      360

gcctgctcta ccaaggcaat aggaagaacc atcttgaaag agaatatcaa gtacgaagtg      420

gccatttttg tccatggacc aactactgtg gagtcgcacg gaaactactc cacacaggtt      480

ggagccactc aggcagggag attcagcatc actcctgcgg cgccttcata cacactaaag      540

cttggagaat atggagaggt gacagtggac tgtgaaccac ggtcagggat tgacaccaat      600

gcatactacg tgatgactgt tggaacaaag acgttcttgg tccatcgtga gtggttcatg      660

gacctcaacc tcccttggag cagtgctgga agtactgtgt ggaggaacag agagacgtta      720

atggagtttg aagaaccaca cgccacgaag cagtctgtga tagcattggg ctcacaagag      780

ggagctctgc atcaagcttt ggctggagcc attcctgtgg aattttcaag caacactgtc      840

aagttgacgt cgggtcattt gaagtgtaga gtgaagatgg aaaaattgca gttgaaggga      900

acaacctatg gcgtctgttc aaaggctttc aagtttcttg ggactcccgc agacacaggt      960

cacggcactg tggtgttgga attgcagtac actggcacgg atggaccttg caaagttcct     1020

atctcgtcag tggcttcatt gaacgaccta acgccagtgg gcagattggt cactgtcaac     1080

ccttttgttt cagtggccac ggccaacgct aaggtcctga ttgaattgga accacccttt     1140

ggagactcat acatagtggt gggcagagga gaacaacaga tcaatcacca ttggcacaag     1200

tctggaagca gcattggcaa agcctttaca accaccctca aaggagcgca gagactagcc     1260

gctctaggag acacagcttg gtag                                            1284


<210>  264
<211>  1506
<212>  DNA
<213>  ArtSeq 	pGP28

<400>  264
atgttcaact gtctgggaat gggcaatcgt gacttcatag aaggagccag tggagccact       60

tgggtggact tggtgctaga aggagatagc tgcttgacaa tcatggcaaa cgacaaacca      120

acattggacg tccgcatgat taacatcgaa gctagtcaac ttgctgaggt cagaagttac      180

tgctatcatg cttcagtcac tgacatctcg acggtggctc ggtgccccac gactggagaa      240

gcccacaacg agaagcgagc tgatagtagc tatgtgtgca aacaaggctt cactgatcgt      300

gggtggggca acggatgtgg actcttcggg aaggggagca ttgacacatg tgcaaaattc      360

tcctgcacta gcaaagcgat tgggagaaca atccagccag aaaacatcaa atacgaagtt      420

ggcatttttg tgcatggaac caccacttca gaaaaccatg ggaattattc agcgcaagtt      480

ggggcttccc aggcggcaaa gtttacagta acacccaatg ctccttcgat aaccctcaaa      540

cttggtgact acggagaagt cacgctggac tgtgagccaa ggagtggact gaacactgaa      600

gcgttttacg tcatgaccgt ggggtcaaag tcatttctgg tccataggga atggtttcat      660

gacctcgctc tcccctggac gtctccttcg agcacagcgt ggagaaacag agaactcctc      720

atggaatttg aagaagcgca cgccacaaaa cagtccgttg ttgctcttgg gtcacaggaa      780

ggaggcctcc atcaggcgct ggcaggggcc attgtggtgg agtactcaag ctcagtaaag      840

ctaacatcag gccacctgaa atgcaggcta aaaatggaca aactggccct gaaaggcaca      900

acctatggca tgtgtacagg aaaattctcg ttcgcgaaaa atccggcgga cactggccac      960

ggaacagttg tcattgaact ctcctactct gggagagacg gcccctgcaa aattccgatt     1020

gtctccgttg cgagccttaa tgacatgact cccgttgggc ggctggtgac agtgaaccct     1080

ttcgtcgcga cttccagtgc taactcaaag gtgctggtcg agatggaacc ccctttcgga     1140

gactcctaca tcgtggttgg gaggggagac aagcagatta accaccattg gcacaaagct     1200

ggaagcacgc taggcaaggc cttttcaaca actttgaagg gggctcaaag gctggcagcg     1260

ttgggcgaca cagcctggga ctttggctct attggagggg tcttcaactc cataggaaaa     1320

gccgtccacc aagtgtttgg tggtgccttc agaacactct tcgggggaat gtcttggatc     1380

acacaagggc taatgggtgc cctactgctt tggatgggcg tcaacgcacg agaccgatca     1440

attgctctgg ccttcttagc cacaggaggt gtgctcgtgt tcttagcgac caatgtgcat     1500

gcttag                                                                1506


<210>  265
<211>  1666
<212>  DNA
<213>  ArtSeq 	pGP31.1

<400>  265
gcaaagcacg tgagatcgcc accatgaaag tcttcctcgt gacctgtctt ggcttcgccg       60

tgttcagcag ttctgtgtgt gtgaatatca acatactgca gcagatcggc tatatcaaac      120

aacaagtgag gcagctctcc tattactctc agagtagcag ctcttacatt gtcgttaagc      180

tgctccccaa tattcaacca acagacaata gttgtgagtt taagtcagta acgcaatata      240

acaaaactct gtctaacctc ttgctcccta tagccgagaa cattaataac attgcatcac      300

catcatctgg aagcagaagg cataaacgct tcgctgggat tgccataggc attgcggccc      360

tcggcgtggc gacagctgcc caagtaaccg cggctgtcag cctcgttcaa gcccagacca      420

atgccagagc tatcgctgcg atgaagaata gcatccaggc cactaaccga gcagtcttcg      480

aagttaagga aggcacacag cggcttgcca tcgcggtaca agccattcaa gatcatatta      540

acacaattat gaatactcaa ctgaataaca tgtcatgtca gatccttgat aaccaactgg      600

ctacatctct gggcttgtac ctgaccgagc tgaccactgt ctttcagccc caactgatca      660

accctgccct gtcacctatc agcattcaag cactcaggtc acttcttggg tccatgactc      720

ccgctgtcgt gcaagctaca ctctcaacat ccatctctgc agccgaaatt ctgtccgctg      780

gcctcatgga aggccaaatt gtgagcgttc tcctcgatga gatgcagatg atagtcaaaa      840

ttaacattcc taccatagtg acgcaatcaa acgcactcgt aatcgacttt tacagtatct      900

ctagcttcat taataaccaa gaatctatca tccaattgcc agatcggatc cttgaaatcg      960

gaaatgaaca gtggagttat cctgcgaaga actgtaaatt gacgagacac cacatcttct     1020

gtcaatacaa tgaggccgaa agactcagcc tcgaatctaa actctgcttg gcaggcaata     1080

tcagcgcctg tgtattcagc cctatcgcag ggtcttatat gcggcgcttt gtagcactcg     1140

acggaacaat agtcgctaac tgccgatcat tgacctgtct gtgcaagagc cccagctacc     1200

ctatttatca acccgaccac catgctgtta ctacgattga cctcactgcg tgccagacct     1260

tgagcctcga tgggctcgat tttagtatag tctctctgag taatataaca tatgctgaaa     1320

acttgacaat cagcctgagt cagactatca acactcagcc cattgatatt tccacggaac     1380

ttagtaaagt aaacgccagc ctgcaaaacg cagttaaata tataaaggaa tccaatcatc     1440

aactccaaag cgtaaacgtt aatagcaaaa taggcgccat cattgtggct gcactggtcc     1500

tctcaatcct gtcaatcatt atcagccttt tgttctgttg ctgggcttac gtagccacta     1560

aagagatcag gcggatcaac ttcaaaacga accacattaa cacaatttca tctagcgtcg     1620

atgatctcat ccggtactta taagatctga attcacccca ccagtg                    1666


<210>  266
<211>  1798
<212>  DNA
<213>  ArtSeq 	pGP31.2

<400>  266
gcaaagcacg tgagatcgcc accatggaac ctagtaagct tttcaccatg tccgataatg       60

ctacattcgc accaggcccc gtcattaacg cagccgacaa gaaaacattc cgtacatgtt      120

tccgcattct ggtcctgtca gtccaggcag tcactcttat tctggtaatt gttactctgg      180

gcgaactcgt tcgcatgatt aacgaccagg gactgtctaa ccagctctcc tctattgccg      240

ataagatcag agagtccgcc accatgatcg catcagcagt cggagtgatg aatcaagtga      300

ttcatggggt gacagtttca ctgccactcc aaatagaagg aaatcaaaat cagcttctct      360

caactcttgc cacgatttgc acaggaaaga agcaggtttc taactgttct actaacatac      420

cattggtgaa tgatctgcgg tttattaatg ggatcaataa gttcatcatt gaagactatg      480

ctacgcatga cttcagcatt ggccacccgc tgaatatgcc tagttttatc ccaacagcca      540

caagccccaa tggttgcacc cggattccgt cctttagctt ggggaaaacc cattggtgct      600

atacccacaa tgttattaac gctaattgca aagatcatac atcttccaat caatacatta      660

gcatgggcat ccttgtacaa acggcctcag gctatcccat gtttaaaact ctgaaaatac      720

aatatctgag cgatggcctg aacaggaaga gttgctctat cgcaaccgtg cctgatgggt      780

gcgcaatgta ctgttatgtg agtacccaac ttgaaaccga tgactatgca ggctcttctc      840

cccctaccca gaaactgaca ctgctgttct ataacgatac tgttacggag cgtaccataa      900

gccccactgg acttgaaggt aattgggcta cccttgtgcc tggagtagga tccggtatct      960

actttgagaa taagctcata ttccctgcgt atggcggggt gctgcccaac agttctctcg     1020

gcgtcaagag tgcacgcgag ttcttcagac cagtgaaccc ctataatccc tgctcagggc     1080

cccaacaaga cttggatcag cgcgcactta gatcctattt tccttcctat tttagtaatc     1140

gtcgagtcca gagcgctttc ctcgtgtgtg cttggaatca gattttggta acaaactgtg     1200

aactggtcgt cccatccaat aatcaaaccc ttatgggagc agaagggcgg gtcctgctta     1260

ttaacaaccg actgctctac taccaaagaa gcacaagttg gtggccatac gaacttctct     1320

atgaaatttc cttcacattc accaacagtg gtcagagctc agtgaatatg agttggatac     1380

ccatatatag ctttacacga cctggatcag gcaactgtag cggggaaaat gtttgtccta     1440

cagcatgtgt aagtggcgtt tatctggatc cgtggccgct taccccatac tcccatcaat     1500

ccggtattaa ccgaaatttc tatttcactg gcgcactctt gaacagtagt acgacaagag     1560

taaaccccac cctgtacgtt tcagctttga acaatcttaa ggtgctggct ccatatggaa     1620

atcagggtct gtttgcttcc tacactacta caacatgttt ccaagatacc ggagatgcct     1680

ctgtatattg tgtgtatatc atggaactgg cgtcaaacat cgtcggcgaa tttcaaatat     1740

tgcccgtcct gactcggctg acaataacct tataagatct gaattcaccc caccagtg       1798


<210>  267
<211>  1747
<212>  DNA
<213>  ArtSeq 	pGP33.1

<400>  267
gcaaagcacg tgagatcgcc accatgactg catacattca aagaagccaa tgcattagca       60

caagtctcct tgtggtgctg acgaccctcg tttcctgtca gatcccgcgt gatcgacttt      120

ccaatatcgg ggttattgtc gacgagggca agtccttgaa aatcgcaggt tcccacgagt      180

ctaggtacat cgtgctgtca ctggttcccg gcgtcgactt tgagaatggt tgcggtacag      240

cccaagtaat tcagtacaag agcctgctca acaggcttct gatccctctc cgagatgcct      300

tggatctgca agaagctctg attactgtga cgaacgacac gactcaaaat gccggggctc      360

cacagtctcg cttcttcggc gcagtgatcg gcacgatcgc tctgggcgtt gccacttccg      420

ctcagatcac cgctggtatt gcccttgctg aagctcggga agccaaacgt gatattgcgc      480

tgataaagga gagcatgaca aagactcata agtcaatcga actgcttcag aacgccgtgg      540

gagagcaaat tcttgctctc aaaaccctgc aggacttcgt gaatgatgag attaaaccag      600

ccatcagtga actgggttgc gagactgctg ctctgcgtct gggaattaaa ctgacccaac      660

attactccga gctcctcact gctttcggct ctaactttgg aacgattgga gagaaaagcc      720

tgacccttca ggctctctct tctctctact ccgccaacat cacagagatt atgacgacga      780

tcaaaacggg gcaatccaac atttatgatg tcatttatac tgagcagatc aaaggtaccg      840

tgatcgatgt tgacctggaa aggtacatgg tgacactctc agtcaaaatc cccatcctca      900

gtgaggtgcc aggcgtattg attcataaag caagcagcat tagctataac atagatgggg      960

aagagtggta cgttaccgtc cccagtcata tactgtctag agccagtttc ctcggtggtg     1020

cagatataac cgactgtgtg gagagccggc tgacctatat ttgtccgcgc gatcccgcac     1080

aattgattcc agacagccag caaaagtgca tcctcgggga caccacacga tgtcctgtta     1140

cgaaggtagt cgactcactg atccccaagt tcgccttcgt caacggtggc gtagttgcca     1200

attgcattgc cagcacttgt acatgtggca caggacgcag acctattagc caagatcgtt     1260

caaagggcgt ggttttcctc acacacgata attgcggact gataggggtg aacggtgttg     1320

aactttacgc taaccgcaga ggacacgatg caacatgggg cgtacagaat ttgacagtcg     1380

ggcctgcaat tgcaatacgt cctatcgaca tctctctcaa cctggcggac gctaccaatt     1440

ttctgcaaga ctccaaggct gaacttgaga aagcgaggaa gattctgtcc gaagtcggcc     1500

gatggtataa ctctcgggaa actgtcatta ccatcattgt cgtgatggtt gtcattttgg     1560

tggtgatcat tgtgataatt attgtcctct ataggctgag gagatctatg ctgatgggta     1620

acccggatga cagaatccca cgcgacacgt acacccttga gccgaaaatt cggcatatgt     1680

atacgaatgg tggatttgat gcaatggcgg aaaagcgctt ataagatctg aattcacccc     1740

accagtg                                                               1747


<210>  268
<211>  1777
<212>  DNA
<213>  ArtSeq 	pGP33.2

<400>  268
gcaaagcacg tgagatcgcc accatggatg gcgaccgagg caaacgcgac tcttattgga       60

gcacttcccc tagtgggtcc accactaagc cggctagcgg atgggagaga tcaagtaagg      120

ccgatacgtg gctcttgatc ttgagcttca cccaatgggc tttgagtatt gctactgtta      180

ttatttgcat catcatctca gctcggcaag gatactctat gaaagagtac agcatgacgg      240

tggaagcatt gaatatgtct tctcgggaag tgaaggaatc actcacatct ttgattaggc      300

aggaagtcat agcccgggct gtgaatatcc aatccagcgt ccaaacaggg atcccggtgc      360

tcctgaacaa gaactcccga gacgtcatcc aaatgatcga taaatcttgt tcacgccaag      420

aacttaccca acattgtgaa agcactattg ccgtccatca cgcagacggc attgcacccc      480

tggagccgca ctcattctgg cgttgcccgg ttggtgaacc ctatctgtca tctgaccccg      540

agatcagtct gctccctgga ccttcactcc tctccggttc caccacgata agcgggtgtg      600

tcaggttgcc atccctctcc atcggggaag cgatttatgc gtatagcagc aacttgatta      660

cgcaaggctg tgctgacatc ggtaagtcct accaggtgct tcagcttggt tatatcagcc      720

ttaattctga tatgtttccg gacctcaatc ctgtggtctc acatacatat gacatcaatg      780

acaacagaaa atcctgtagc gtagtcgcaa cagggacgag agggtatcaa ctctgttcta      840

tgcctacagt cgacgagaga actgattata gctcagacgg aatcgaagat ctcgtcctgg      900

acgttctcga tttgaaaggt cgcacaaaat cacaccgcta cagaaattcc gaggtggacc      960

tcgatcatcc tttctccgcg ttgtatccta gtgtgggcaa cggcattgct actgaaggct     1020

ccttgatttt cctcgggtac ggcggcctca ccacaccctt gcaaggtgat acaaaatgcc     1080

gtacgcaagg ctgccaacag gtttctcaag atacttgcaa cgaggctctg aagataactt     1140

ggcttggcgg gaaacaagtg gtttctgtga tcattcaggt caatgattac ctgagtgaaa     1200

ggcctaaaat tagggtcacc accattccca ttacccaaaa ctatctcggt gctgagggca     1260

ggctgttgaa gctcggtgat cgggtctata tatatactcg gagcagtggt tggcactctc     1320

aactgcaaat aggggtcttg gacgtgtccc acccgttgac cattaattgg acacctcatg     1380

aggcgctgtc acggccaggg aataaagaat gcaactggta caataagtgc cccaaagaat     1440

gtatctccgg ggtctacaca gacgcttacc ccctgtctcc agatgctgct aatgtcgcta     1500

cagttactct gtacgccaat acttctagag tgaaccccac tattatgtat tccaacacga     1560

ccaatataat caatatgctt cggataaaag atgtacaact tgaagccgct tacactacta     1620

cgtcctgtat aacacacttt gggaaaggct attgctttca catcattgag attaatcaaa     1680

agagtctgaa tactctccaa cccatgctgt ttaaaacatc aatcccaaaa ttgtgtaaag     1740

cggaaagttt ataagatctg aattcacccc accagtg                              1777


<210>  269
<211>  1590
<212>  DNA
<213>  ArtSeq 	pGP59

<400>  269
atgctgctcg tgaaccagag ccaccagggc ttcaacaagg agcatacatc caaaatggtg       60

tccgccatcg tgctgtacgt gctgctggcc gccgctgccc acagcgcttt tgccgccgag      120

cattgtaatg ctcagatgaa aaccggccct tacaagatca agaacctgga catcacccct      180

cctaaggaga cactgcaaaa agacgtggaa atcaccatcg tggaaaccga ctacaatgag      240

aacgtgatca tcggatataa gggctactac caggcctacg cctacaacgg cggaagcctg      300

gatcctaaca ccagagtgga agagaccatg aagaccctga acgtgggaaa ggaagatctg      360

ctgatgtgga gcatccggca acagtgtgaa gtgggcgaag agctgattga tagatggggc      420

tcagattctg acgattgctt cagagacaac gagggcagag gccagtgggt gaagggcaag      480

gagctggtca agcggcagaa caacaaccac ttcgcccatc acacatgcaa caaaagctgg      540

cggtgcggca tctccacctc taagatgtat tctagactgg aatgtcagga cgacaccgac      600

gagtgccagg tgtacatcct ggacgctgaa ggaaacccta tcaacgtgac agttgacacc      660

gtgctgcacc gggacggcgt gtctatgatc ctgaagcaga agagcacatt caccaccaga      720

cagatcaagg ccgcatgcct gcttatcaaa gacgacaaga acaaccccga gagcgtgacc      780

agagaacact gcctgatcga caacgacatc tacgacctga gcaagaatac ttggaactgt      840

aaattcaaca ggtgcatcaa gcggaaggtg gagcacagag tgaagaagcg tccaccaacc      900

tggcgccaca acgtcagagc caagtacaca gagggcgaca cagccacaaa gggagatctg      960

atgcacatcc aggaggaact gatgtacgag aatgacctgc ttaaaatgaa catcgagctg     1020

atgcacgccc acatcaacaa gctgaacaac atgctgcacg acctgatcgt tagcgtggcc     1080

aaggtggacg agagactgat cggcaatctg atgaacaaca gcgtgtccag caccttcctg     1140

tctgatgaca cctttctgct catgccttgc accaaccccc ccgcccacac cagcaactgc     1200

tacaacaaca gcatctacaa ggaaggcaga tgggtcgcta ataccgatag cagtcagtgc     1260

atcgacttca gcaattacaa ggagctggcc atcgacgatg atgtggagtt ctggattcct     1320

acaattggca acacaaccta ccacgatagc tggaaggacg ccagcggatg gtcttttatc     1380

gcccagcaga aaagcaatct gatcaccacc atggaaaata ccaagttcgg cggcgtgggt     1440

acatctctga gcgacatcac aagcatggcc gagggcgagc tggccgccaa gctgaccagc     1500

ttcatgttcg gccacgtcgt gaacttcgtg atcatcctga tcgtgattct gttcctgtac     1560

tgcatgatca gaaaccggaa cagacaatac                                      1590


<210>  270
<211>  2955
<212>  DNA
<213>  ArtSeq 	pGP54

<400>  270
atgtctgccg cgctgatgat gtgtatcctt gccaacacct ctttcccctg ctcatcacct       60

ccctgctacc cctgctgcta cgaaaaacag ccagaacaga cactgcggat gctggaagac      120

aatgtgaata gaccagggta ctatgagcta ctggaagcgt ccatgacatg cagaaacaga      180

tcacgccacc gccgtagtgt aacagagcac ttcaatgtgt ataaggctac tagaccgtac      240

ttagcgtatt gcgctgactg tggggacggg tacttctgct atagcccagt tgctatcgag      300

aagatccgag atgaggcgcc tgacggcatg ctcaagatcc aagtctccgc ccaaataggt      360

ctggacaagg caggtaccca cgcccacacg aagatccgat atatggctgg tcatgatgtt      420

caggaatcta agagagactc cttgagggtg tacacgtccg cagcgtgctc tatacatggg      480

acgatgggac acttcatcgt cgcacattgt ccgccaggcg actacctcaa ggtttcgttc      540

gaggacgcag attcacacgt gaaggcatgt aaggtccaat acaagcacga cccattgccg      600

gtgggtagag agaagttcgt ggttagaccc cactttggcg tagagctgcc atgcacctca      660

taccagctga caacagctcc caccgacgag gagatcgaca tgcacacacc gccagatata      720

ccggatcgca ccctgctatc acagacggcg ggcaacgtca aaataacagc aggcggcagg      780

actatcaggt acaattgtac ctgtggccgt gacaacgtag gcactaccag tactgacaag      840

accatcaaca catgcaagat tgaccaatgc catgctgccg ttaccagcca tgacaaatgg      900

caatttacct ctccatttgt tcccagggct gatcagacag ctaggagggg caaagtgcat      960

gttccattcc ctttgactaa cgtcacctgc cgagtgccgt tggctcgagc gccggatgtc     1020

acctatggta agaaggaggt gaccctgaga ttacacccag atcatccgac gctcttctcc     1080

tataggagtt taggagccga accgcacccg tacgaggagt gggttgacaa gttctctgag     1140

cgcatcatcc cagtgacgga agaagggatt gagtaccagt ggggcaacaa cccgccggtc     1200

cgcctatggg cgcaactgac gaccgagggc aaaccccatg gctggccaca tgaaatcatt     1260

cagtactatt atggactata ccccgccgcc accattgccg cagtatccgg ggcgagtctg     1320

atggccctcc taactctagc ggccacatgc tgcatgctgg ccaccgcgag gagaaagtgc     1380

ctaacaccat acgccttgac gccaggagcg gtggtaccgt tgacactggg gctgctttgc     1440

tgcgcaccga gggcgaacgc agcatcattc gctgagacta tggcatatct gtgggacgag     1500

aacaaaaccc tcttttggat ggaattcgcc gccccagccg cagcgcttgc tttgctggca     1560

tgctgtatca aaagcctgat ctgctgttgt aagccatttt cttttttagt gttactgagc     1620

ctgggagcct ccgcaaaagc ttacgagcac acagccacaa ttccgaatgt ggtggggttc     1680

ccgtataagg ctcacattga aaggaatggc ttctcgccca tgactctgca gcttgaagtg     1740

gtggagacaa gctgggaacc cacacttaac ctggagtaca ttacctgcga atacaagacg     1800

gtggtccctt cgccattcat caaatgttgc ggaacatcag aatgctcatc caaggagcag     1860

ccagactacc aatgcaaggt gtacacgggt gtatacccat tcatgtgggg tggagcctac     1920

tgtttctgcg actccgagaa cacgcagctc agcgaggcct atgtcgacag gtcagacgtt     1980

tgcaaacatg atcacgcatc ggcctacaag gcacacacgg cctctctaaa agcaacaatc     2040

aggatcagtt atggcaccat caaccagacc accgaggcct tcgttaatgg tgaacacgcg     2100

gtcaacgtgg gcggaagcaa gttcatcttt ggaccgatct caacagcttg gtcaccgttc     2160

gacaataaaa ttgtcgtgta taaagatgat gtctacaacc aggacttccc accctacgga     2220

tcaggccagc cgggtagatt cggagacatt cagagcagga cagtggagag caaagacttg     2280

tatgccaaca cggccctaaa actctcaaga ccatcacccg gggttgtgca tgtgccatac     2340

acgccgacac catccggatt taaatattgg ctgaaggaga aaggatcttc attgaataca     2400

aaggcccctt ttggctgcaa gataaagacc aatccagtca gagccatgga ttgtgcagtt     2460

ggcagtatac ctgtgtcgat ggacatacct gacagtgcat tcacacgagt ggtagatgcc     2520

ccggctgtaa cagacctgag ctgccaggta gtggtctgta cacactcctc cgatttcgga     2580

ggagttgcca cattgtctta caaaacggac aaacccggca agtgcgctgt ccactcacat     2640

tccaacgtcg caacgttgca agaggcgacg gtggatgtca aggaggatgg caaggtcaca     2700

gtgcactttt ccacggcgtc cgcctccccg gccttcaaag tgtccgtctg tgacgcaaaa     2760

acaacgtgca cggcggcgtg cgagcctcca aaagaccaca tcgtccctta tggggcgagc     2820

cataacaacc aggtctttcc ggacatgtca ggaactgcga tgacgtgggt gcagaggctg     2880

gccagtgggt taggtgggct ggctctcatc gcggtggttg tgctggtctt ggtaacctgc     2940

ataacaatgc gtcgg                                                      2955


<210>  271
<211>  1407
<212>  DNA
<213>  ArtSeq 	pGP82

<400>  271
atgaatccta atcagaaaat cattaccatc ggtagcatct gcatgatcgt gggcattatc       60

agcctgatcc tgcagatcgg caacatcatc agcatctggg tgtcccacag catccagacc      120

ggaaatcaga accaacctga gatctgcaac cagagcatca ttacatacga gaacaacaca      180

tgggtcaacc aaacatacgt gaacatcagc aacaccaact tcgtgaccga gcaggccctg      240

gctcctgtgg ccctggccgg caacagcagc ctgtgcccca tttcaggatg ggccatctac      300

agcaaggaca acggcatccg gatcggaagc aagggcgatg tgttcgtgat ccgcgagcct      360

ttcatctctt gcagccatct ggaatgtaga acttttttcc tgacccaggg cgccctgctg      420

aatgataagc actctaatgg gaccgtgaaa gacagaagcc cttatagaac cctgatgagc      480

tgtcctatcg gcgaaagccc ttctccttac aacagcagat tcgagagcgt ggcttggtcc      540

gcctctgctt gtcacgacgg catcggctgg ctgaccatcg gcatcagcgg tccagataac      600

ggcgctgtgg ccgttctgaa gtacaacggc atcatcacag atacaatcaa gagctggcgg      660

aacaacatcc tgcggacaca ggagagcgag tgcgcctgta tgaacggctc ctgctttacc      720

atcatgaccg atggccctag caacggccag gccagctaca agatcttcaa gatcgagaag      780

ggcaaggtgg tgaaaagcgt cgagctgaac gcccctaact accactacga ggaatgcagc      840

tgttaccctg acgccggaga aatcatgtgc gtgtgccggg acaactggca cggcagcaat      900

agaccctggg ttagcttcaa ccagaacctg gagtaccaga tcggctacat ctgtagtggg      960

gtgttcggcg acaaccccag acctaatgac ggcgcaggca gctgcggccc cgtgagcagc     1020

aacggagcct acggagtgaa gggattctcc tttaagtacg gcaaaggagt gtggatcggc     1080

agaaccaagt caacaagcag cagatctggc ttcgagatga tctgggaccc caacggctgg     1140

accgaaaccg acagcagctt cagcgtgaag caggacattg tggccatcac cgactggtcc     1200

ggatattctg gctctttcgt ccagcaccct gaactgacag gcctggactg catgagacca     1260

tgcttctggg tggaactgat caggggccgg cccaaggaaa acaccatctg gaccagcggc     1320

tctagcatca gcttttgcgg cgtgaatagt gatacagtgg gctggagctg gcctgatggc     1380

gccgagctcc ccttcaccat cgacaag                                         1407


<210>  272
<211>  1485
<212>  DNA
<213>  ArtSeq 	pGP75

<400>  272
atgaggtgca tcggcatcag caacagggac ttcgtggagg gcgtgagcgg cggcagctgg       60

gtggacatcg tgctggagca cggcagctgc gtgaccacca tggccaagaa caagcccacc      120

ctggacttcg agctgatcaa gaccgaggcc aagcaccccg ccaccctgag gaagtactgc      180

gtggaggcca agctgaccaa caccaccacc gccagcaggt gccccaccca gggcgagccc      240

agcctgaacg aggagcagga caagaggttc gtgtgcaagc acagcatggt ggacaggggc      300

tggggcaacg gctgcggcct gttcggcaag ggcggcatcg tgacctgcgc catgttcacc      360

tgcaagaaga acatggaggg caaggtggtg cagcccgaga acctggagta caccatcgtg      420

atcacccccc acagcggcga ggagaacgcc gtgggcaacg acaccggcaa gcacggcaag      480

gagatcaagg tgacccccca gagcagcatc accgaggccg agctgaccgg ctacggcacc      540

gtgaccatgg agtgcagccc caggaccggc ctggacttca acgagatggt gctgctgcag      600

atggagaaca aggcctggct ggtgcacagg cagtggttcc tggacctgcc cctgccctgg      660

ctgcccggcg ccgacaccca gggcagcaac tggatccaga aggagaccct ggtgaccttc      720

aagaaccccc acgccaagaa gcaggacgtg gtggtgctgg gcagccagga gggcgccatg      780

cacaccgccc tgaccggcgc caccgagatc cagatgagca gcggcaacct gctgttcacc      840

ggccacctga agtgcaggct gaggatggac aagctgcagc tgaagggcat gagctacagc      900

atgtgcaccg gcaagttcaa ggtggtgaag gagatcgccg agacccagca cggcaccatc      960

gtgatcaggg tgcagtacga gggcgacggc agcccctgca agatcccctt cgagatcatg     1020

gacctggaga agaggcacgt gctgggcagg ctgatcaccg tgaaccccat cgtgaccgag     1080

aaggacagcc ccgtgaacat cgaggccgag ccccccttcg gcgacagcta catcatcatc     1140

ggcgtggagc ccggccagct gaagctgagc tggttcaaga agggcagcag catcggccag     1200

atgttcgaga ccaccatgag gggcgccaag aggatggcca tcctgggcga caccgcctgg     1260

gacttcggca gcctgggcgg cgtgttcacc agcatcggca aggccctgca ccaggtgttc     1320

ggcgccatct acggcgccgc cttcagcggc gtgagctgga ccatgaagat cctgatcggc     1380

gtggtgatca cctggatcgg catgaacagc aggagcacca gcctgagcgt gagcctggtg     1440

ctggtgggcg tggtgaccct gtacctgggc gtgatggtgc aggcc                     1485


<210>  273
<211>  1479
<212>  DNA
<213>  ArtSeq 	pGP76

<400>  273
atgaggtgcg tgggcgtggg caacagggac ttcgtggagg gcctgagcgg cgccacctgg       60

gtggacgtgg tgctggagca cggcggctgc gtgaccacca tggccaagaa caagcccacc      120

ctggacatcg agctgcagaa gaccgaggcc acccagctgg ccaccctgag gaagctgtgc      180

atcgagggca agatcaccaa catcaccacc gacagcaggt gccccaccca gggcgaggcc      240

atcctgcccg aggagcagga ccagaactac gtgtgcaagc acacctacgt ggacaggggc      300

tggggcaacg gctgcggcct gttcggcaag ggcagcctgg tgacctgcgc caagttccag      360

tgcctggaga gcatcgaggg caaggtggtg cagcacgaga acctgaagta caccgtgatc      420

atcaccgtgc acaccggcga ccagcaccag gtgggcaacg agacccaggg cgtgaccgcc      480

gagatcacca gccaggccag caccgccgag gccatcctgc ccgagtacgg caccctgggc      540

ctggagtgca gccccaggac cggcctggac ttcaacgaga tgatcctgct gaccatgaag      600

aacaaggcct ggatggtgca caggcagtgg ttcttcgacc tgcccctgcc ctggaccagc      660

ggcgccacca ccaagacccc cacctggaac aggaaggagc tgctggtgac cttcaagaac      720

gcccacgcca agaagcagga ggtggtggtg ctgggcagcc aggagggcgc catgcacacc      780

gccctgaccg gcgccaccga gatccagacc agcggcggca ccagcatctt cgccggccac      840

ctgaagtgca ggctgaagat ggacaagctg aagctgaagg gcatgagcta cgccatgtgc      900

ctgaacacct tcgtgctgaa gaaggaggtg agcgagaccc agcacggcac catcctgatc      960

aaggtggagt acaagggcga ggacgccccc tgcaagatcc ccttcagcac cgaggacggc     1020

cagggcaagg cccacaacgg caggctgatc accgccaacc ccgtggtgac caagaaggag     1080

gagcccgtga acatcgaggc cgagcccccc ttcggcgaga gcaacatcgt gatcggcatc     1140

ggcgacaagg ccctgaagat caactggtac aggaagggca gcagcatcgg caagatgttc     1200

gaggccaccg ccaggggcgc caggaggatg gccatcctgg gcgacaccgc ctgggacttc     1260

ggcagcgtgg gcggcgtgct gaacagcctg ggcaagatgg tgcaccagat cttcggcagc     1320

gcctacaccg ccctgttcag cggcgtgagc tggatcatga agatcggcat cggcgtgctg     1380

ctgacctgga tcggcctgaa cagcaagaac accagcatga gcttcagctg catcgccatc     1440

ggcatcatca ccctgtacct gggcgtggtg gtgcaggcc                            1479


<210>  274
<211>  216
<212>  DNA
<213>  ArtSeq 	pGP77

<400>  274
ttcggcagcg tgggcggcct gttcaccagc ctgggcaagg ccgtgcacca ggtgttcggc       60

agcgtgtaca ccaccatgtt cggcggcgtg agctggatga tcaggatcct gatcggcttc      120

ctggtgctgt ggatcggcac caacagcagg aacaccagca tggccatgac ctgcatcgcc      180

gtgggcggca tcaccctgtt cctgggcttc accgtg                                216


<210>  275
<211>  1647
<212>  DNA
<213>  ArtSeq 	pGP34.1

<400>  275
gccaccatgg tggtgatcct ggataagcgg tgctactgta atctgctgat tctgattctc       60

atgatctctg aatgcagcgt aggaatcctg cactacgaga agctgagcaa gatcggactg      120

gtgaaaggcg tgacccgcaa gtacaagatc aaaagcaacc ctctgaccaa ggacatcgtg      180

atcaagatga tacccaatgt gtccaacatg agccaatgta ccggcagcgt gatggaaaac      240

tacaagaccc ggctgaacgg catcctgacc ccaatcaagg gcgccctgga aatctacaaa      300

aacaacaccc acgacctggt gggcgacgtg cggctggctg gcgtgatcat ggccggcgtg      360

gccatcggca tcgccaccgc cgcccagatc accgccggag tggcccttta tgaggccatg      420

aagaacgccg acaacatcaa caagctgaag agtagcatcg agtctacaaa cgaggccgtg      480

gtgaagctgc aggagacagc cgagaaaacc gtctatgtgc tgacagctct gcaggactac      540

atcaacacca atctggtgcc taccatcgac aagatcagct gcaagcagac agagctgagc      600

ctggacctgg ccctgtctaa gtacctgagc gacctgctgt tcgtcttcgg acctaatttg      660

caggatcctg tgagcaacag catgaccatc caggccatta gccaggcttt tggcggcaac      720

tacgagacac tgctcagaac actgggctac gccacagaag acttcgacga cctgctggaa      780

agcgatagca tcaccggaca gatcatctac gtggacctga gcagctacta cattatcgtg      840

agagtgtact tccccattct gaccgagatc cagcaggcct acatccagga gctgctgcct      900

gtgtccttca ataatgataa ctcagaatgg atcagcatcg tgcccaactt catcctcgtg      960

cggaacaccc tgatcagcaa catcgagatc ggcttctgcc tgatcaccaa gcggagcgtg     1020

atctgcaacc aggactacgc cacccctatg acaaacaaca tgagagagtg cctgaccggc     1080

agcacagaga agtgccccag agaactggtc gtgtctagcc acgtgccaag attcgctctg     1140

tccaatggcg tgctgtttgc caactgcatc agcgtcacct gtcagtgtca gaccaccggc     1200

agagccatca gccagagcgg cgagcagacc ctgctgatga tcgacaatac tacatgccct     1260

accgctgtgc tgggaaatgt gatcatctcc ctgggcaagt atctgggttc cgttaactac     1320

aactccgagg gcatcgccat cggccctcct gttttcaccg acaaggtgga catctcctct     1380

cagatcagca gcatgaacca gtctctgcaa caaagcaagg attacatcaa ggaagctcaa     1440

agactgctgg acacagtgaa ccccagcctg atcagcatgc tgagcatgat catcctgtac     1500

gtgctgtcta tcgcctctct gtgcatcggc ctcatcacat ttatcagctt catcattgtt     1560

gaaaaaaaga gaaacacata cagcagactg gaagatagaa gggtgcggcc tacaagctct     1620

ggcgatctgt actacatcgg cacctga                                         1647


<210>  276
<211>  8527
<212>  DNA
<213>  ArtSeq 	pGP34.2

<400>  276
gccaccatgc ctgctgagaa caagaaggtg cggttcgaga acacaacctc cgataaggga       60

aagatcccca gcaaggtgat taagtcttat tacggcacca tggacatcaa gaagatcaat      120

gaaggcctcc tcgacagcaa gattctgtcc gcctttaaca cagtgatcgc cctgctggga      180

agcattgtga tcatcgtcat gaacatcatg atcatccaga actacaccag atctacagat      240

aatcaagccg ttatcaagga cgccctgcag ggcatccagc agcagatcaa gggcctggcc      300

gacaagatcg gcacagaaat cgggcctaag gtgtccctga tcgacaccag cagcaccatc      360

accatcccag ccaacatcgg actgctgggt agcaagatct cccagagcac agcctcgatt      420

aacgagaacg tgaacgaaaa gtgcaagttc accctgccac ctctgaagat ccacgagtgc      480

aacataagct gtcctaaccc tctgcctttt cgggaatacc ggccccagac agagggagtg      540

agcaatctgg tgggcctgcc gaacaacatc tgcctgcaga aaaccagcaa tcaaatcctg      600

aaacctaaac tgatctctta tacactgcct gtggtgggcc agtctggcac ctgtatcacc      660

gaccccctgc tggctatgga tgagggctac ttcgcctaca gccatctgga acggatcggc      720

tcttgtagca gaggcgtgtc caaacagaga atcatcggcg ttggcgaggt cctggataga      780

ggagatgaag tgccttctct gttcatgaca aacgtgtgga cccctccaaa ccctaacacc      840

gtgtaccact gcagcgccgt gtacaacaac gagttttact acgtgttgtg cgccgtatcc      900

accgtgggcg accctatcct gaacagcacc tactggagcg gcagcctgat gatgaccaga      960

cttgccgtga agcctaaaag caacggcggc ggatataacc agcaccagct ggctctgaga     1020

tctatcgaga agggcagata cgacaaggtg atgccctacg gcccttctgg catcaagcag     1080

ggcgacacac tgtacttccc cgctgtgggt ttcctggtgc ggaccgagtt caagtacaat     1140

gacagcaact gccccatcac caagtgtcag tactccaaac ccgagaactg cagactgtcc     1200

atgggcatca gacctaatag ccactacatc ctgaggagcg gcctgctgaa atacaacctg     1260

tctgacggcg agaatcctaa ggtggtgttc atcgagatct ctgaccagcg cctgagcatc     1320

ggaagtccta gcaagatcta cgatagcctg ggccagcctg tgttctacca ggcgagcttc     1380

agctgggaca ccatgatcaa attcggcgac gtgctgaccg tgaacccact ggtcgtgaac     1440

tggcgaaaca acacggtgat cagcagacct ggccagagcc aatgtcccag attcaataca     1500

tgccccgaaa tctgctggga gggagtgtac aacgacgctt tcctcatcga cagaatcaac     1560

tggatcagcg ccggcgtgtt cctggacagc aatcagacag ccgagaatcc cgtgtttaca     1620

gtgtttaaag ataacgaaat cctgtacaga gcccagctgg ccagcgaaga taccaacgcc     1680

cagaagacca tcacaaattg cttcctgctg aagaacaaga tctggtgcat ctccctggtg     1740

gaaatctacg acaccggcga taacgtgatc cggcctaagc tgttcgccgt taagatcccc     1800

gagcagtgca cctgatctag aagttgtctc ctcctgcact gactgactga tacaatcgat     1860

ttctggatcc gcaggcctaa tcaacctctg gattacaaaa tttgtgaaag attgactggt     1920

attcttaact atgttgctcc ttttacgcta tgtggatacg ctgctttaat gcctttgtat     1980

catgctattg cttcccgtat ggctttcatt ttctcctcct tgtataaatc ctggttgctg     2040

tctctttatg aggagttgtg gcccgttgtc aggcaacgtg gcgtggtgtg cactgtgttt     2100

gctgacgcaa cccccactgg ttggggcatt gccaccacct gtcagctcct ttccgggact     2160

ttcgctttcc ccctccctat tgccacggcg gaactcatcg ccgcctgcct tgcccgctgc     2220

tggacagggg ctcggctgtt gggcactgac aattccgtgg tgttgtcggg gaagctgacg     2280

tcctttccat ggctgctcgc ctgtgttgcc acctggattc tgcgcgggac gtccttctgc     2340

tacgtccctt cggccctcaa tccagcggac cttccttccc gcggcctgct gccggctctg     2400

cggcctcttc cgcgtcttcg ccttcgccct cagacgagtc ggatctccct ttgggccgcc     2460

tccccgcctg tctagcttga ctgactgaga tacagcgtac cttcagctca cagacatgat     2520

aagatacatt gatgagtttg gacaaaccac aactagaatg cagtgaaaaa aatgctttat     2580

ttgtgaaatt tgtgatgcta ttgctttatt tgtaaccatt ataagctgca ataaacaagt     2640

taacaacaac aattgcattc attttatgtt tcaggttcag ggggaggtgt gggaggtttt     2700

ttaaagcaag taaaacctct acaaatgtgg tattggccca tctctatcgg tatcgtagca     2760

taaccccttg gggcctctaa acgggtcttg aggggttttt tgtgcccctc gggccggatt     2820

gctatctacc ggcattggcg cagaaaaaaa tgcctgatgc gacgctgcgc gtcttatact     2880

cccacatatg ccagattcag caacggatac ggcttcccca acttgcccac ttccatacgt     2940

gtcctcctta ccagaaattt atccttaagg tcgtcagcta tcctgcaggc gatctctcga     3000

tttcgatcaa gacattcctt taatggtctt ttctggacac cactaggggt cagaagtagt     3060

tcatcaaact ttcttccctc cctaatctca ttggttacct tgggctatcg aaacttaatt     3120

aagcgatctg catctcaatt agtcagcaac catagtcccg cccctaactc cgcccatccc     3180

gcccctaact ccgcccagtt ccgcccattc tccgccccat cgctgactaa ttttttttat     3240

ttatgcagag gccgaggccg cctcggcctc tgagctattc cagaagtagt gaggaggctt     3300

ttttggaggc ctaggctttt gcaaaggagg tagccaacat gattgaacaa gatggattgc     3360

acgcaggttc tcccgccgct tgggtggaga ggctattcgg ctatgactgg gcacaacaga     3420

caatcggctg ctctgatgcc gccgtgttcc ggctgtcagc gcaggggcgc ccggttcttt     3480

ttgtcaagac cgacctgtcc ggtgccctga atgaactcca ggacgaggca gcgcggctat     3540

cgtggctggc cacgacgggc gttccttgcg cagctgtgct cgacgttgtc actgaagcgg     3600

gaagggactg gctgctattg ggcgaagtgc cggggcagga tctcctgtca tctcaccttg     3660

ctcctgccga gaaagtatcc atcatggctg atgcaatgcg gcggctgcat acgcttgatc     3720

cggctacctg cccattcgac caccaagcga aacatcgcat cgagcgagca cgtactcgga     3780

tggaagccgg tcttgtcgat caggatgatc tggacgaaga gcatcagggg ctcgcgccag     3840

ccgaactgtt cgccaggctc aaggcgcgga tgcccgacgg cgaggatctc gtcgtgaccc     3900

acggcgatgc ctgcttgccg aatatcatgg tggaaaatgg ccgcttttct ggattcatcg     3960

actgtggccg gctgggtgtg gcggaccgct atcaggacat agcgttggct acccgtgata     4020

ttgctgaaga gcttggcggc gaatgggctg accgcttcct cgtgctttac ggtatcgccg     4080

ctcccgattc gcagcgcatc gccttctatc gccttcttga cgagttcttc tagtatgtaa     4140

gccctgtgcc ttctagttgc cagccatctg ttgtttgccc ctcccccgtg ccttccttga     4200

ccctggaagg tgccactccc actgtccttt cctaataaaa tgaggaaatt gcatcgcatt     4260

gtctgagtag gtgtcattct attctggggg gtggggtggg gcaggacagc aagggggagg     4320

attgggaaga caatagcagg catgctgggg atgcggtggg ctctatggtt aattaaccag     4380

tcaagtcagc tacttggcga gatcgacttg tctgggtttc gactacgctc agaattgcgt     4440

cagtcaagtt cgatctggtc cttgctattg cacccgttct ccgattacga gtttcattta     4500

aatcatgtga gcaaaaggcc agcaaaaggc caggaaccgt aaaaaggccg cgttgctggc     4560

gtttttccat aggctccgcc cccctgacga gcatcacaaa aatcgacgct caagtcagag     4620

gtggcgaaac ccgacaggac tataaagata ccaggcgttt ccccctggaa gctccctcgt     4680

gcgctctcct gttccgaccc tgccgcttac cggatacctg tccgcctttc tcccttcggg     4740

aagcgtggcg ctttctcata gctcacgctg taggtatctc agttcggtgt aggtcgttcg     4800

ctccaagctg ggctgtgtgc acgaaccccc cgttcagccc gaccgctgcg ccttatccgg     4860

taactatcgt cttgagtcca acccggtaag acacgactta tcgccactgg cagcagccac     4920

tggtaacagg attagcagag cgaggtatgt aggcggtgct acagagttct tgaagtggtg     4980

gcctaactac ggctacacta gaagaacagt atttggtatc tgcgctctgc tgaagccagt     5040

taccttcgga aaaagagttg gtagctcttg atccggcaaa caaaccaccg ctggtagcgg     5100

tggttttttt gtttgcaagc agcagattac gcgcagaaaa aaaggatctc aagaagatcc     5160

tttgatcttt tctacggggt ctgacgctca gtggaacgaa aactcacgtt aagggatttt     5220

ggtcatgaga ttatcaaaaa ggatcttcac ctagatcctt ttaaattaaa aatgaagttt     5280

taaatcaatc taaagtatat atgagtaaac ttggtctgac agttaccaat gcttaatcag     5340

tgaggcacct atctcagcga tctgtctatt tcgttcatcc atagttgcat ttaaatttcc     5400

gaactctcca aggccctcgt cggaaaatct tcaaaccttt cgtccgatcc atcttgcagg     5460

ctacctctcg aacgaactat cgcaagtctc ttggccggcc ttgcgccttg gctattgctt     5520

ggcagcgcct atcgccaggt attactccaa tcccgaatat ccgagatcgg gatcacccga     5580

gagaagttca acctacatcc tcaatcccga tctatccgag atccgaggaa tatcgaaatc     5640

ggggcgcgcc tggtgtaccg agaacgatcc tctcagtgcg agtctcgacg atccatatcg     5700

ttgcttggca gtcagccagt cggaatccag cttgggaccc aggaagtcca atcgtcagat     5760

attgtactca agcctggtca cggcagcgta ccgatctgtt taaacctaga tattgatagt     5820

ctgatcggtc aacgtataat cgagtcctag cttttgcaaa catctatcaa gagacaggat     5880

cagcaggagg ctttcgcatg agtattcaac atttccgtgt cgcccttatt cccttttttg     5940

cggcattttg ccttcctgtt tttgctcacc cagaaacgct ggtgaaagta aaagatgctg     6000

aagatcagtt gggtgcgcga gtgggttaca tcgaactgga tctcaacagc ggtaagatcc     6060

ttgagagttt tcgccccgaa gaacgctttc caatgatgag cacttttaaa gttctgctat     6120

gtggcgcggt attatcccgt attgacgccg ggcaagagca actcggtcgc cgcatacact     6180

attctcagaa tgacttggtt gagtattcac cagtcacaga aaagcatctt acggatggca     6240

tgacagtaag agaattatgc agtgctgcca taaccatgag tgataacact gcggccaact     6300

tacttctgac aacgattgga ggaccgaagg agctaaccgc ttttttgcac aacatggggg     6360

atcatgtaac tcgccttgat cgttgggaac cggagctgaa tgaagccata ccaaacgacg     6420

agcgtgacac cacgatgcct gtagcaatgg caacaacctt gcgtaaacta ttaactggcg     6480

aactacttac tctagcttcc cggcaacagt tgatagactg gatggaggcg gataaagttg     6540

caggaccact tctgcgctcg gcccttccgg ctggctggtt tattgctgat aaatctggag     6600

ccggtgagcg tgggtctcgc ggtatcattg cagcactggg gccagatggt aagccctccc     6660

gtatcgtagt tatctacacg acggggagtc aggcaactat ggatgaacga aatagacaga     6720

tcgctgagat aggtgcctca ctgattaagc attggtaacc gattctaggt gcattggcgc     6780

agaaaaaaat gcctgatgcg acgctgcgcg tcttatactc ccacatatgc cagattcagc     6840

aacggatacg gcttccccaa cttgcccact tccatacgtg tcctccttac cagaaattta     6900

tccttaagat cccgaatcgt ttaaactcga ctctggctct atcgaatctc cgtcgtttcg     6960

agcttacgcg aacagccgtg gcgctcattt gctcgtcggg catcgaatct cgtcagctat     7020

cgtcagctta cctttttggc agcgatcgcg gctcccgaca tcttggacca ttagctccac     7080

aggtatcttc ttccctctag tggtcataac agcagcttca gctacctctc aattcaaaaa     7140

acccctcaag acccgtttag aggccccaag gggttatgct atcaatcgtt gcgttacaca     7200

cacaaaaaac caacacacat ccatcttcga tggatagcga ttttattatc taactgctga     7260

tcgagtgtag ccagatctag taatcaatta cggggtcatt agttcatagc ccatatatgg     7320

agttccgcgt tacataactt acggtaaatg gcccgcctgg ctgaccgccc aacgaccccc     7380

gcccattgac gtcaataatg acgtatgttc ccatagtaac gccaataggg actttccatt     7440

gacgtcaatg ggtggagtat ttacggtaaa ctgcccactt ggcagtacat caagtgtatc     7500

atatgccaag tacgccccct attgacgtca atgacggtaa atggcccgcc tggcattatg     7560

cccagtacat gaccttatgg gactttccta cttggcagta catctacgta ttagtcatcg     7620

ctattaccat gctgatgcgg ttttggcagt acatcaatgg gcgtggatag cggtttgact     7680

cacggggatt tccaagtctc caccccattg acgtcaatgg gagtttgttt tggcaccaaa     7740

atcaacggga ctttccaaaa tgtcgtaaca actccgcccc attgacgcaa atgggcggta     7800

ggcgtgtacg gtgggaggtc tatataagca gagctggttt agtgaaccgt cagatcgcct     7860

ggagacgcca tccacgctgt tttgacctcc atagaagaca ccgggaccga tccagcctcc     7920

cctcgaagct tacatgtggt accgagctcg gatcctgaga acttcagggt gagtctatgg     7980

gacccttgat gttttctttc cccttctttt ctatggttaa gttcatgtca taggaagggg     8040

agaagtaaca gggtacacat attgaccaaa tcagggtaat tttgcatttg taattttaaa     8100

aaatgctttc ttcttttaat atactttttt gtttatctta tttctaatac tttccctaat     8160

ctctttcttt cagggcaata atgatacaat gtatcatgcc tctttgcacc attctaaaga     8220

ataacagtga taatttctgg gttaaggcaa tagcaatatt tctgcatata aatatttctg     8280

catataaatt gtaactgatg taagaggttt catattgcta atagcagcta caatccagct     8340

accattctgc ttttatttta tggttgggat aaggctggat tattctgagt ccaagctagg     8400

cccttttgct aatcatgttc atacctctta tcttcctccc acagctcctg ggcaacgtgc     8460

tggtctgtgt gctggcccat cactttggca aaggcggccg ctgccaagct tccgagctct     8520

cgaattc                                                               8527


<210>  277
<211>  1647
<212>  DNA
<213>  ArtSeq 	pGP35.1

<400>  277
gccaccatgg ccacgcagga ggtgcgcctg aagtgcctgc tctgtggcat catcgtgctg       60

gtcctgagcc tggaaggcct gggcatcctg cactacgaga agctgagcaa gatcggactg      120

gtgaagggca tcacaagaaa gtataagatc aagagcaatc ctctgaccaa agacatcgtc      180

atcaagatga ttcctaacgt ctccaatgtg tccaagtgca caggaacagt gatggaaaac      240

tataagagca gactgaccgg catcctgtct ccaatcaaag gcgccatcga gctgtacaac      300

aacaacaccc acgaccttgt tggcgacgtg aagctggccg gcgtggtgat ggccggcatc      360

gccatcggca ttgccacagc tgctcagatc accgccggag tggccctgta cgaggccatg      420

aagaacgccg acaacatcaa caagctgaaa agcagcatcg agagcaccaa cgaggccgtg      480

gtgaaactgc aggagaccgc cgagaagacc gtgtacgttc tgaccgccct gcaggactac      540

atcaacacaa acctggtccc caccatcgac cagatcagct gcaaacagac agagctggcc      600

ctggacctgg ctcttagtaa atacctgtct gatctgctgt tcgtgttcgg ccctaacctg      660

caagaccccg tgtctaatag catgacaatc caggccatct cccaggcttt tggcggaaat      720

tatgaaaccc tgctgagaac cctgggctac gccacagaag atttcgacga tctcctggaa      780

agcgacagca tcgccggcca gatcgtctac gtggacctga gctcctacta cattattgtg      840

cgggtgtact tccccatcct gactgaaatc cagcaggctt acgtgcagga gctgctgcct      900

gtgtctttta acaacgacaa cagcgagtgg atctctatcg tgcccaattt cgtgctgatc      960

cggaacacac tgatcagcaa catcgaggtg aagtactgcc tgatcacaaa gaagtctgtg     1020

atctgcaacc aggactacgc cacccctatg accgcatctg tgcgggaatg cctgacaggc     1080

agcaccgata agtgtcctag agagctggtg gtgagcagcc acgtgcctag atttgccctg     1140

agcggcggcg tgctcttcgc caactgcatc agtgttacat gccagtgcca aacaaccggc     1200

agagccatca gccagagcgg tgagcagacc ctgctgatga tcgacaatac cacctgtacc     1260

accgtggtcc tgggcaatat catcattagc ctggggaagt acctgggatc tatcaactac     1320

aattctgagt ctatcgccgt tggaccacct gtgtacaccg acaaggtgga tatcagcagc     1380

cagatcagca gcatgaacca gagccttcaa caaagcaagg actacatcaa ggaagcccag     1440

aagatcctgg acaccgtgaa ccccagcctg atcagcatgc tgagcatgat catcctgtac     1500

gtgctgtcca tagccgctct gtgtatcggc ctgatcacct tcatcagctt cgtgatcgtg     1560

gaaaagaaaa gaggcaacta cagcagactg gatgatagac aggtgcggcc tgtgtccaac     1620

ggcgacctgt attacatcgg cacctga                                         1647


<210>  278
<211>  1821
<212>  DNA
<213>  ArtSeq 	pGP35.2

<400>  278
gccaccatga tggccgactc taagctggtg tccctgaaca acaatctgtc cggcaagatc       60

aaagatcagg gcaaggtgat taagaactac tacggcacaa tggacatcaa gaagatcaac      120

gacggcctgc tggacagcaa gatcctggga gccttcaaca cagtgatcgc cctgctcgga      180

agcatcatca tcattgtgat gaacatcatg atcatccaga actacacaag aacaaccgac      240

aaccaggccc tgatcaaaga aagcctgcag agcgttcagc agcagatcaa agccctgacc      300

gacaagatcg gcaccgaaat cggacctaag gtgtccctga tcgacacctc ttctacaatc      360

accatccccg ctaatatcgg actgctgggc tctaagatca gtcagagcac gagcagcatc      420

aacgagaacg tgaacgacaa gtgcaagttc accctgcctc cactgaaaat tcatgagtgc      480

aacatcagct gtcctaaccc cctgcccttc agagaataca gacctatcag ccagggagtt      540

tctgatctgg tgggcctgcc aaatcagatc tgcctgcaaa agaccaccag cacaatcctg      600

aagccccgcc tgatctctta taccctgccc atcaacaccc gggaaggcgt gtgcatcacc      660

gaccctctgc tggccgtgga caacggcttc ttcgcctaca gccacctgga aaagatcggc      720

tcttgcacca gaggcatcgc aaagcaaaga atcatcggcg tgggcgaagt gctggaccgg      780

ggcgataagg tgcccagcat gtttatgacc aacgtgtgga cccctcctaa ccctagcaca      840

atccaccact gttccagcac ctaccacgag gacttctact acaccctgtg cgccgtgagc      900

cacgtgggcg accccatcct gaatagcacc agctggaccg agagcctgag cctgatccgg      960

ctggccgtgc ggcctaagag cgactctgga gattacaacc aaaagtacat cgctatcacc     1020

aaggtggaac ggggcaaata cgataaggtg atgccttacg gcccgagcgg catcaaacag     1080

ggcgacaccc tgtacttccc tgctgtggga tttctgccta ggaccgagtt ccagtacaat     1140

gacagcaact gccccatcat tcactgcaag tattccaagg ccgagaactg tagactgagc     1200

atgggcgtga actcaaagtc tcactacatc ctgagaagcg gcctgctgaa gtacaacctg     1260

agcctgggcg gagatatcat cctgcagttc atagagatcg ctgataatag actgacaatc     1320

ggcagccctt ctaaaatcta caactccctc ggccagcctg tgttctacca agccagctac     1380

agctgggaca ccatgatcaa gctgggcgat gtggacaccg tggaccctct cagagtgcag     1440

tggcggaaca acagcgtgat cagcagaccc ggccagagcc agtgtcctag attcaacgtg     1500

tgtcctgagg tgtgctggga gggcacatat aatgacgcct ttctgattga cagactgaac     1560

tgggtgtccg ccggcgtgta cctgaactct aatcagaccg ccgagaaccc cgtgttcgcc     1620

gtctttaagg acaacgagat cctgtaccaa gtgccactgg ctgaagatga tacaaacgcc     1680

cagaaaacaa ttacagattg cttcctgctt gagaatgtca tctggtgcat ctcgctggtc     1740

gagatctacg acaccggcga cagcgtgatc agaccaaagc tgttcgccgt gaagatccct     1800

gcccagtgca gcgagagctg a                                               1821


<210>  279
<211>  1656
<212>  DNA
<213>  ArtSeq 	pGP37.1

<400>  279
atgggcagca gaccttcaac caagaatccc gctccaatga tgctgacaat ccgggtggcc       60

ctggtcctgt cttgcatctg tcctgctaat agcatcgacg gcaggcccct ggccgctgca      120

ggcatcgttg tgaccggcga taaggccgtg aacatctaca cctcttcaca gaccggcagc      180

attatcgtca agctgctgcc taacctgccc aaggacaaag aggcctgcgc caaggcccct      240

ctggatgcct acaaccggac cctgaccacc ttactgacac ctctgggaga tagcatcaga      300

cgcatccagg agagcgtgac aaccagcgga ggcggcagac agggccggct gatcggagcc      360

atcatcggcg gcgttgccct gggcgtggct acagccgcac agatcaccgc cgccgctgct      420

ctgatccagg ccaaacagaa cgccgccaac atcctgagac tgaaggaatc catcgccgcg      480

acgaacgagg ccgtgcacga ggtgacagac ggcctgtccc agctggctgt tgccgtgggc      540

aagatgcagc agttcgtgaa cgaccagttt aacaagaccg ctcaggagct ggactgcatt      600

aagatcgccc agcaggtcgg cgtggaactg aacctgtacc tgacagagct gaccaccgtg      660

ttcggacctc agatcacatc ccccgctctc aacaaactga caattcaagc cctgtataac      720

ctggccggcg gcaatatgga ctacctgctg accaagctgg gcgtgggcaa caaccagctg      780

tctagcctga tcggcagcgg cctgatcaca ggcaacccca tcctgtacga cagccagaca      840

cagctcctcg gaatccaggt gaccgcccct agcgtgggaa acctgaacaa catgcgggcc      900

acatacctgg aaaccctgag cgtgtccacc accagaggct tcgccagcgc ccttgtgccc      960

aaggtggtga cccaagtggg ctctgtgatc gaggaactgg acacctccta ctgtatcgag     1020

accgacctgg atctgtactg caccagaatc gtgacttttc ctatgagccc tggcatctac     1080

agctgcctga gcggcaatac cagcgcctgc atgtatagca agaccgaagg cgccttgacc     1140

accccttaca tgaccatcaa gggcagcgtg atcgccaact gcaagatgac aacatgccgg     1200

tgcgtgaacc ctccaggcat catcagccag aactacggcg aagccgtgtc tctgatcgac     1260

aagcagagct gtaacgtgct gagccttggt gggataaccc tgagactgag cggcgagttc     1320

gacgtgacct accagaaaaa catcagcatc caggacagcc aggtgatcat cacaggaaat     1380

ctggatatca gcaccgagct gggcaacgtg aacaattcta ttagcaacgc cctgaacaaa     1440

ctggaagagt ccaatagaaa gctggacaaa gtgaatgtga agctgacaag cacctctgcc     1500

ctgatcacct acatcgtgct gaccatcatc agcctggtgt tcggcatcct gtccctgatc     1560

ctcgcctgtt acctgatgta caagcaaaag gcccaacaga aaaccctgct gtggctgggc     1620

aataacaccc tggatcagat gagagccacc acaaag                               1656


<210>  280
<211>  1734
<212>  DNA
<213>  ArtSeq 	pGP37.2

<400>  280
atggaccggg ccgtgagtca ggtggccctg gaaaacgacg agagagaggc caagaacacc       60

tggcggctga tcttccggat cgccatcctc ttcctgaccg tggtgacact ggctatttct      120

gtggcctctc tgctgtacag catgggcgct agcacaccta gcgacctggt gggcatccca      180

accagaatca gcagagctga agaaaaaatc acctccaccc tcggaagcaa ccaggacgtg      240

gtggacagaa tctacaagca ggtggccctg gaaagcccac tggccctgct caacaccgag      300

acaaccatca tgaacgccat caccagcctg agctatcaga tcaacggcgc tgccaacaac      360

agcggctggg gcgcccctat ccacgacccc gattacatcg gcggaattgg caaggaactg      420

atcgtggatg acgccagcga tgtgacaagc ttttacccta gcgcctttca ggagcacctg      480

aacttcattc ccgctccaac caccggcagc ggctgcacca gaatccctag cttcgacatg      540

agcgccaccc actactgcta cacacacaac gtgatcctgt ccggctgccg ggaccacagc      600

cacagctacc aatacctggc cctgggtgtg ctgagaacct ctgccacagg cagagtattc      660

ttcagcacac tgagatctat caacctggac gatacccaga acagaaagag ctgcagcgtg      720

agcgccacgc ccctgggctg tgatatgctg tgctccaagg tgacagaaac cgaggaagag      780

gactacaaca gcgccgtgcc caccagaatg gtgcacggcc ggctgggctt cgacggacag      840

taccacgaga aggatctgga tgtgacaacc ctgtttggcg actgggtcgc caattacccc      900

ggcgttggcg gcggctcttt catcgacagc cgcgtgtggt tcagcgtgta cggcggcctg      960

aaacctaaca gcccttccga caccgtgcag gagggcaagt acgtgatcta caaaagatac     1020

aacgacacct gccctgatga gcaggactac cagatcagaa tggccaaaag cagctacaag     1080

cctggccggt tcggcggaaa gagaatccag caggccatcc tgtctatcaa ggtgtctacc     1140

tctctgggag aggaccctgt gctgacagtg ccacctaata ccgtgaccct gatgggcgct     1200

gaaggcagaa tcctgaccgt gggcaccagc catttcctgt accaaagagg ctcttcatat     1260

tttagccccg ccctgctgta ccctatgaca gtgtctaaca aaaccgccac actgcacagc     1320

ccttatacat tcaacgcctt cacccggcct ggcagcatcc catgtcaggc aagcgctaga     1380

tgccccaata gctgtgtgac cggagtttac actgatcctt accccctgat cttctaccgg     1440

aaccacaccc tccggggagt ctttggcacc atgctggacg gagtgcaggc cagactgaat     1500

cctgctagcg ccgtgttcga cagcacctcc cggtcccgga taacaagagt ctctagctcc     1560

agcaccaagg ccgcctacac aacaagcaca tgcttcaagg tcgtgaagac caacaagaca     1620

tactgtctga gcatcgccga gatctctaat accctgttcg gcgagttcag aatcgtgcct     1680

ctgctggtcg agatcctgaa ggacgacggc gtgcgggaag ccagaagcgg ctga           1734


<210>  281
<211>  599
<212>  PRT
<213>  Measles morbillivirus

<400>  281

Met Gly Ser Arg Ile Val Ile Asn Arg Glu His Leu Met Ile Asp Arg 
1               5                   10                  15      


Pro Tyr Val Leu Leu Ala Val Leu Phe Val Met Phe Leu Ser Leu Ile 
            20                  25                  30          


Gly Leu Leu Ala Ile Ala Gly Ile Arg Leu His Arg Ala Ala Ile Tyr 
        35                  40                  45              


Thr Ala Glu Ile His Lys Ser Leu Ser Thr Asn Leu Asp Val Thr Asn 
    50                  55                  60                  


Ser Ile Glu His Gln Val Lys Asp Val Leu Thr Pro Leu Phe Lys Ile 
65                  70                  75                  80  


Ile Gly Asp Glu Val Gly Leu Arg Thr Pro Gln Arg Phe Thr Asp Leu 
                85                  90                  95      


Val Lys Phe Ile Ser Asp Lys Ile Lys Phe Leu Asn Pro Asp Arg Glu 
            100                 105                 110         


Tyr Asp Phe Arg Asp Leu Thr Trp Cys Ile Asn Pro Pro Glu Arg Ile 
        115                 120                 125             


Lys Leu Asp Tyr Asp Gln Tyr Cys Ala Asp Val Ala Ala Glu Glu Leu 
    130                 135                 140                 


Met Asn Ala Leu Val Asn Ser Thr Leu Leu Glu Thr Arg Thr Thr Asn 
145                 150                 155                 160 


Gln Phe Leu Ala Val Ser Lys Gly Asn Cys Ser Gly Pro Thr Thr Ile 
                165                 170                 175     


Arg Gly Gln Phe Ser Asn Met Ser Leu Ser Leu Leu Asp Leu Tyr Leu 
            180                 185                 190         


Ser Arg Gly Tyr Asn Val Ser Ser Ile Val Thr Met Thr Ser Gln Gly 
        195                 200                 205             


Met Tyr Gly Gly Thr Tyr Leu Val Glu Lys Pro Asn Leu Ser Ser Lys 
    210                 215                 220                 


Gly Ser Glu Leu Pro Gln Pro Ser Met His Arg Val Phe Glu Val Gly 
225                 230                 235                 240 


Val Ile Arg Asn Pro Gly Leu Gly Ala Pro Val Phe His Met Thr Asn 
                245                 250                 255     


Tyr Phe Glu Gln Pro Val Ser Asn Asp Phe Ser Asn Cys Met Val Ala 
            260                 265                 270         


Leu Gly Glu Leu Lys Leu Ala Ala Leu Cys His Gly Glu Asp Ser Ile 
        275                 280                 285             


Thr Ile Pro Tyr Gln Gly Ser Gly Lys Gly Val Ser Phe Gln Leu Val 
    290                 295                 300                 


Lys Leu Gly Val Trp Lys Ser Pro Thr Asp Met Gln Ser Trp Val Pro 
305                 310                 315                 320 


Leu Ser Thr Asp Asp Pro Val Ile Asp Arg Leu Tyr Leu Ser Ser His 
                325                 330                 335     


Arg Gly Ile Ile Ala Asp Asn Gln Ala Lys Trp Ala Val Pro Thr Thr 
            340                 345                 350         


Arg Thr Asp Asp Lys Leu Arg Met Glu Thr Cys Phe Gln Gln Ala Cys 
        355                 360                 365             


Lys Gly Lys Ile Gln Ala Leu Cys Glu Asn Pro Glu Trp Ala Pro Leu 
    370                 375                 380                 


Lys Asp Asn Arg Ile Pro Ser Tyr Gly Val Leu Ser Val Asp Leu Ser 
385                 390                 395                 400 


Leu Ala Val Glu Leu Lys Ile Lys Ile Ala Ser Gly Phe Gly Pro Leu 
                405                 410                 415     


Ile Thr His Gly Ser Gly Met Asp Leu Tyr Lys Ser Asn His Asn Asn 
            420                 425                 430         


Val Tyr Trp Leu Thr Ile Pro Pro Met Lys Asn Leu Ala Leu Gly Val 
        435                 440                 445             


Ile Asn Thr Leu Glu Trp Ile Pro Arg Phe Lys Val Ser Pro Asn Leu 
    450                 455                 460                 


Phe Thr Val Pro Ile Lys Glu Ala Gly Glu Asp Cys His Ala Pro Thr 
465                 470                 475                 480 


Tyr Leu Pro Ala Glu Val Asp Gly Asp Val Lys Leu Ser Ser Asn Leu 
                485                 490                 495     


Val Ile Leu Pro Gly Gln Asp Leu Gln Tyr Val Leu Ala Thr Tyr Asp 
            500                 505                 510         


Thr Ser Arg Val Glu His Ala Val Val Tyr Tyr Val Tyr Ser Pro Ser 
        515                 520                 525             


Arg Ser Phe Ser Tyr Phe Tyr Pro Phe Arg Leu Pro Ile Lys Gly Val 
    530                 535                 540                 


Pro Ile Glu Leu Gln Val Glu Cys Phe Thr Trp Asp Gln Lys Leu Trp 
545                 550                 555                 560 


Cys Arg His Phe Cys Val Leu Ala Asp Ser Glu Ser Gly Gly His Ile 
                565                 570                 575     


Thr His Ser Gly Met Val Gly Met Gly Val Ser Cys Thr Val Thr Arg 
            580                 585                 590         


Glu Asp Gly Thr Asn Arg Gly 
        595                 


<210>  282
<211>  526
<212>  PRT
<213>  Measles morbillivirus

<400>  282

Met Gly Leu Lys Val Asn Val Ser Ala Ile Phe Met Ala Val Leu Leu 
1               5                   10                  15      


Thr Leu Gln Thr Pro Thr Gly Gln Ile His Trp Gly Asn Leu Ser Lys 
            20                  25                  30          


Ile Gly Val Val Gly Ile Gly Ser Ala Ser Tyr Lys Val Met Thr Arg 
        35                  40                  45              


Ser Ser His Gln Ser Leu Val Ile Lys Leu Met Pro Asn Ile Thr Leu 
    50                  55                  60                  


Leu Asn Asn Cys Thr Arg Val Glu Ile Ala Glu Tyr Arg Arg Leu Leu 
65                  70                  75                  80  


Arg Thr Val Leu Glu Pro Ile Arg Asp Ala Leu Asn Ala Met Thr Gln 
                85                  90                  95      


Asn Ile Arg Pro Val Gln Ser Val Ala Ser Ser Arg Arg His Lys Arg 
            100                 105                 110         


Phe Ala Gly Val Val Leu Ala Gly Ala Ala Leu Gly Val Ala Thr Ala 
        115                 120                 125             


Ala Gln Ile Thr Ala Gly Ile Ala Leu His Gln Ser Met Leu Asn Ser 
    130                 135                 140                 


Gln Ala Ile Asp Asn Leu Arg Ala Ser Leu Glu Thr Thr Asn Gln Ala 
145                 150                 155                 160 


Ile Glu Ala Ile Arg Gln Ala Gly Gln Glu Met Ile Leu Ala Val Gln 
                165                 170                 175     


Gly Val Gln Asp Tyr Ile Asn Asn Glu Leu Ile Pro Ser Met Asn Gln 
            180                 185                 190         


Leu Ser Cys Asp Leu Ile Gly Gln Lys Leu Gly Leu Lys Leu Leu Arg 
        195                 200                 205             


Tyr Tyr Thr Glu Ile Leu Ser Leu Phe Gly Pro Ser Leu Arg Asp Pro 
    210                 215                 220                 


Ile Ser Ala Glu Ile Ser Ile Gln Ala Leu Ser Tyr Ala Leu Gly Gly 
225                 230                 235                 240 


Asp Ile Asn Lys Val Leu Glu Lys Leu Gly Tyr Ser Gly Gly Asp Leu 
                245                 250                 255     


Leu Gly Ile Leu Glu Ser Arg Gly Ile Lys Ala Arg Ile Thr His Val 
            260                 265                 270         


Asp Thr Glu Ser Tyr Phe Ile Val Leu Ser Ile Ala Tyr Pro Thr Leu 
        275                 280                 285             


Ser Glu Ile Lys Gly Val Ile Val His Arg Leu Glu Gly Val Ser Tyr 
    290                 295                 300                 


Asn Ile Gly Ser Gln Glu Trp Tyr Thr Thr Val Pro Lys Tyr Val Ala 
305                 310                 315                 320 


Thr Gln Gly Tyr Leu Ile Ser Asn Phe Asp Glu Ser Ser Cys Thr Phe 
                325                 330                 335     


Met Pro Glu Gly Thr Val Cys Ser Gln Asn Ala Leu Tyr Pro Met Ser 
            340                 345                 350         


Pro Leu Leu Gln Glu Cys Leu Arg Gly Ser Thr Lys Ser Cys Ala Arg 
        355                 360                 365             


Thr Leu Val Ser Gly Ser Phe Gly Asn Arg Phe Ile Leu Ser Gln Gly 
    370                 375                 380                 


Asn Leu Ile Ala Asn Cys Ala Ser Ile Leu Cys Lys Cys Tyr Thr Thr 
385                 390                 395                 400 


Gly Thr Ile Ile Asn Gln Asp Pro Asp Lys Ile Leu Thr Tyr Ile Ala 
                405                 410                 415     


Ala Asp His Cys Pro Val Val Glu Val Asn Gly Val Thr Ile Gln Val 
            420                 425                 430         


Gly Ser Arg Arg Tyr Pro Asp Ala Val Tyr Leu His Arg Ile Asp Leu 
        435                 440                 445             


Gly Pro Pro Ile Ser Leu Glu Arg Leu Asp Val Gly Thr Asn Leu Gly 
    450                 455                 460                 


Asn Ala Ile Ala Lys Leu Glu Asp Ala Lys Glu Leu Leu Glu Ser Ser 
465                 470                 475                 480 


Asp Gln Ile Leu Arg Ser Met Lys Gly Leu Ser Ser Thr Ser Ile Val 
                485                 490                 495     


Tyr Ile Leu Ile Ala Val Cys Leu Gly Gly Leu Ile Gly Ile Pro Ala 
            500                 505                 510         


Leu Ile Cys Cys Cys Arg Gly Arg Cys Asn Lys Lys Gly Glu 
        515                 520                 525     


<210>  283
<211>  569
<212>  PRT
<213>  Nipah henipaviru

<400>  283

Met Lys Lys Ile Asn Glu Gly Leu Leu Asp Ser Lys Ile Leu Ser Ala 
1               5                   10                  15      


Phe Asn Thr Val Ile Ala Leu Leu Gly Ser Ile Val Ile Ile Val Met 
            20                  25                  30          


Asn Ile Met Ile Ile Gln Asn Tyr Thr Arg Ser Thr Asp Asn Gln Ala 
        35                  40                  45              


Val Ile Lys Asp Ala Leu Gln Gly Ile Gln Gln Gln Ile Lys Gly Leu 
    50                  55                  60                  


Ala Asp Lys Ile Gly Thr Glu Ile Gly Pro Lys Val Ser Leu Ile Asp 
65                  70                  75                  80  


Thr Ser Ser Thr Ile Thr Ile Pro Ala Asn Ile Gly Leu Leu Gly Ser 
                85                  90                  95      


Lys Ile Ser Gln Ser Thr Ala Ser Ile Asn Glu Asn Val Asn Glu Lys 
            100                 105                 110         


Cys Lys Phe Thr Leu Pro Pro Leu Lys Ile His Glu Cys Asn Ile Ser 
        115                 120                 125             


Cys Pro Asn Pro Leu Pro Phe Arg Glu Tyr Arg Pro Gln Thr Glu Gly 
    130                 135                 140                 


Val Ser Asn Leu Val Gly Leu Pro Asn Asn Ile Cys Leu Gln Lys Thr 
145                 150                 155                 160 


Ser Asn Gln Ile Leu Lys Pro Lys Leu Ile Ser Tyr Thr Leu Pro Val 
                165                 170                 175     


Val Gly Gln Ser Gly Thr Cys Ile Thr Asp Pro Leu Leu Ala Met Asp 
            180                 185                 190         


Glu Gly Tyr Phe Ala Tyr Ser His Leu Glu Arg Ile Gly Ser Cys Ser 
        195                 200                 205             


Arg Gly Val Ser Lys Gln Arg Ile Ile Gly Val Gly Glu Val Leu Asp 
    210                 215                 220                 


Arg Gly Asp Glu Val Pro Ser Leu Phe Met Thr Asn Val Trp Thr Pro 
225                 230                 235                 240 


Pro Asn Pro Asn Thr Val Tyr His Cys Ser Ala Val Tyr Asn Asn Glu 
                245                 250                 255     


Phe Tyr Tyr Val Leu Cys Ala Val Ser Thr Val Gly Asp Pro Ile Leu 
            260                 265                 270         


Asn Ser Thr Tyr Trp Ser Gly Ser Leu Met Met Thr Arg Leu Ala Val 
        275                 280                 285             


Lys Pro Lys Ser Asn Gly Gly Gly Tyr Asn Gln His Gln Leu Ala Leu 
    290                 295                 300                 


Arg Ser Ile Glu Lys Gly Arg Tyr Asp Lys Val Met Pro Tyr Gly Pro 
305                 310                 315                 320 


Ser Gly Ile Lys Gln Gly Asp Thr Leu Tyr Phe Pro Ala Val Gly Phe 
                325                 330                 335     


Leu Val Arg Thr Glu Phe Lys Tyr Asn Asp Ser Asn Cys Pro Ile Thr 
            340                 345                 350         


Lys Cys Gln Tyr Ser Lys Pro Glu Asn Cys Arg Leu Ser Met Gly Ile 
        355                 360                 365             


Arg Pro Asn Ser His Tyr Ile Leu Arg Ser Gly Leu Leu Lys Tyr Asn 
    370                 375                 380                 


Leu Ser Asp Gly Glu Asn Pro Lys Val Val Phe Ile Glu Ile Ser Asp 
385                 390                 395                 400 


Gln Arg Leu Ser Ile Gly Ser Pro Ser Lys Ile Tyr Asp Ser Leu Gly 
                405                 410                 415     


Gln Pro Val Phe Tyr Gln Ala Ser Phe Ser Trp Asp Thr Met Ile Lys 
            420                 425                 430         


Phe Gly Asp Val Leu Thr Val Asn Pro Leu Val Val Asn Trp Arg Asn 
        435                 440                 445             


Asn Thr Val Ile Ser Arg Pro Gly Gln Ser Gln Cys Pro Arg Phe Asn 
    450                 455                 460                 


Thr Cys Pro Glu Ile Cys Trp Glu Gly Val Tyr Asn Asp Ala Phe Leu 
465                 470                 475                 480 


Ile Asp Arg Ile Asn Trp Ile Ser Ala Gly Val Phe Leu Asp Ser Asn 
                485                 490                 495     


Gln Thr Ala Glu Asn Pro Val Phe Thr Val Phe Lys Asp Asn Glu Ile 
            500                 505                 510         


Leu Tyr Arg Ala Gln Leu Ala Ser Glu Asp Thr Asn Ala Gln Lys Thr 
        515                 520                 525             


Ile Thr Asn Cys Phe Leu Leu Lys Asn Lys Ile Trp Cys Ile Ser Leu 
    530                 535                 540                 


Val Glu Ile Tyr Asp Thr Gly Asp Asn Val Ile Arg Pro Lys Leu Phe 
545                 550                 555                 560 


Ala Val Lys Ile Pro Glu Gln Cys Thr 
                565                 


<210>  284
<211>  524
<212>  PRT
<213>  Nipah henipaviru

<400>  284

Met Val Val Ile Leu Asp Lys Arg Cys Tyr Cys Asn Leu Leu Ile Leu 
1               5                   10                  15      


Ile Leu Met Ile Ser Glu Cys Ser Val Gly Ile Leu His Tyr Glu Lys 
            20                  25                  30          


Leu Ser Lys Ile Gly Leu Val Lys Gly Val Thr Arg Lys Tyr Lys Ile 
        35                  40                  45              


Lys Ser Asn Pro Leu Thr Lys Asp Ile Val Ile Lys Met Ile Pro Asn 
    50                  55                  60                  


Val Ser Asn Met Ser Gln Cys Thr Gly Ser Val Met Glu Asn Tyr Lys 
65                  70                  75                  80  


Thr Arg Leu Asn Gly Ile Leu Thr Pro Ile Lys Gly Ala Leu Glu Ile 
                85                  90                  95      


Tyr Lys Asn Asn Thr His Asp Leu Val Gly Asp Val Arg Leu Ala Gly 
            100                 105                 110         


Val Ile Met Ala Gly Val Ala Ile Gly Ile Ala Thr Ala Ala Gln Ile 
        115                 120                 125             


Thr Ala Gly Val Ala Leu Tyr Glu Ala Met Lys Asn Ala Asp Asn Ile 
    130                 135                 140                 


Asn Lys Leu Lys Ser Ser Ile Glu Ser Thr Asn Glu Ala Val Val Lys 
145                 150                 155                 160 


Leu Gln Glu Thr Ala Glu Lys Thr Val Tyr Val Leu Thr Ala Leu Gln 
                165                 170                 175     


Asp Tyr Ile Asn Thr Asn Leu Val Pro Thr Ile Asp Lys Ile Ser Cys 
            180                 185                 190         


Lys Gln Thr Glu Leu Ser Leu Asp Leu Ala Leu Ser Lys Tyr Leu Ser 
        195                 200                 205             


Asp Leu Leu Phe Val Phe Gly Pro Asn Leu Gln Asp Pro Val Ser Asn 
    210                 215                 220                 


Ser Met Thr Ile Gln Ala Ile Ser Gln Ala Phe Gly Gly Asn Tyr Glu 
225                 230                 235                 240 


Thr Leu Leu Arg Thr Leu Gly Tyr Ala Thr Glu Asp Phe Asp Asp Leu 
                245                 250                 255     


Leu Glu Ser Asp Ser Ile Thr Gly Gln Ile Ile Tyr Val Asp Leu Ser 
            260                 265                 270         


Ser Tyr Tyr Ile Ile Val Arg Val Tyr Phe Pro Ile Leu Thr Glu Ile 
        275                 280                 285             


Gln Gln Ala Tyr Ile Gln Glu Leu Leu Pro Val Ser Phe Asn Asn Asp 
    290                 295                 300                 


Asn Ser Glu Trp Ile Ser Ile Val Pro Asn Phe Ile Leu Val Arg Asn 
305                 310                 315                 320 


Thr Leu Ile Ser Asn Ile Glu Ile Gly Phe Cys Leu Ile Thr Lys Arg 
                325                 330                 335     


Ser Val Ile Cys Asn Gln Asp Tyr Ala Thr Pro Met Thr Asn Asn Met 
            340                 345                 350         


Arg Glu Cys Leu Thr Gly Ser Thr Glu Lys Cys Pro Arg Glu Leu Val 
        355                 360                 365             


Val Ser Ser His Val Pro Arg Phe Ala Leu Ser Asn Gly Val Leu Phe 
    370                 375                 380                 


Ala Asn Cys Ile Ser Val Thr Cys Gln Cys Gln Thr Thr Gly Arg Ala 
385                 390                 395                 400 


Ile Ser Gln Ser Gly Glu Gln Thr Leu Leu Met Ile Asp Asn Thr Thr 
                405                 410                 415     


Cys Pro Thr Ala Val Leu Gly Asn Val Ile Ile Ser Leu Gly Lys Tyr 
            420                 425                 430         


Leu Gly Ser Val Asn Tyr Asn Ser Glu Gly Ile Ala Ile Gly Pro Pro 
        435                 440                 445             


Val Phe Thr Asp Lys Val Asp Ile Ser Ser Gln Ile Ser Ser Met Asn 
    450                 455                 460                 


Gln Ser Leu Gln Gln Ser Lys Asp Tyr Ile Lys Glu Ala Gln Arg Leu 
465                 470                 475                 480 


Leu Asp Thr Val Asn Pro Ser Leu Ile Ser Met Leu Ser Met Ile Ile 
                485                 490                 495     


Leu Tyr Val Leu Ser Ile Ala Ser Leu Cys Ile Gly Leu Ile Thr Phe 
            500                 505                 510         


Ile Ser Phe Ile Ile Val Glu Lys Lys Arg Asn Thr 
        515                 520                 


<210>  285
<211>  20
<212>  DNA
<213>  ArtSeq 	guide RNA

<400>  285
ctgcattcta gttgtggttt                                                   20


<210>  286
<211>  522
<212>  PRT
<213>  Queensland carbovirus

<400>  286

Met Ile Ser Phe Asn Leu Ile Leu Leu Ile Leu Val Pro Gly Gln Gln 
1               5                   10                  15      


Lys Glu Gly Arg Ser Lys Leu Arg Ser Ser Arg Leu Val Leu Leu Gln 
            20                  25                  30          


Phe Cys Gln Pro Leu Leu Pro Tyr Ile Leu Ile Tyr Leu Val Val Pro 
        35                  40                  45              


Gly Met Thr Leu Gly Cys Asn Ile Ser Thr Thr Gly Leu Ile Cys Asn 
    50                  55                  60                  


Leu Thr Ser Thr Pro Thr Arg Ile Ala Leu Asn Trp Thr Phe Pro Cys 
65                  70                  75                  80  


Asp Glu Ala Asn Pro Asp Asp Gln Gln Pro Ala Glu Cys Asn Ile Thr 
                85                  90                  95      


Leu Met Thr His Asp Pro Thr Pro Leu His Ala Lys Ala Glu Lys Cys 
            100                 105                 110         


Tyr Val Tyr Val Cys Thr Thr Ser Phe Gly Phe Trp Gly Val Tyr Ser 
        115                 120                 125             


Glu Ser Arg Glu Ile Thr Arg Thr Leu His Arg Asp Glu Cys Asn Phe 
    130                 135                 140                 


Val Glu Glu Ile Pro Glu Asp Pro Tyr Gln Cys Asp Tyr Trp Trp Cys 
145                 150                 155                 160 


Gln Tyr Asn Val Lys Thr Glu Lys Cys Leu Cys Ile Thr Glu Asn Val 
                165                 170                 175     


Thr Val Val Gly Leu Pro Asn Gly His Leu Tyr Cys Ser Phe Glu Asp 
            180                 185                 190         


Cys Ser Thr Leu Ser Ser Gly Thr Lys Leu Gln His Thr Pro Thr Leu 
        195                 200                 205             


Thr Lys Ile Leu Ile Leu Asn Asn Thr Ser His Glu Asn Val Thr Tyr 
    210                 215                 220                 


Leu Asn Gln Pro Ala Thr Ile Ile Asn Ser Thr Arg Val Met Ile His 
225                 230                 235                 240 


Ser Leu His Lys Glu Tyr Thr Ile Tyr Asn Gly Thr Ile Asn Ala Thr 
                245                 250                 255     


Asp Leu Ser Gly Val Cys Ser Glu Lys Thr Gln Ile Lys Arg Arg Lys 
            260                 265                 270         


Arg Asp Ala Gly Gln Gly Tyr Thr Val Asp Ser Ile Gly His Leu Leu 
        275                 280                 285             


Tyr Pro Gly Phe Glu Ala Cys Arg Leu Leu Arg Thr Leu Leu Pro Ala 
    290                 295                 300                 


Ile Ala Leu Gln Pro Leu Leu Asp His Thr Pro Leu Ile Gln Ala Trp 
305                 310                 315                 320 


Phe Asn Asn Asp Ser Leu Ala Gly Lys Val Val Ser Asp Thr Ala Leu 
                325                 330                 335     


Ile Trp Thr Cys Lys Lys Val Ser Cys Asp Leu Gln Asn Leu Ser Thr 
            340                 345                 350         


Asn Ser Leu Tyr Phe Pro Val Ser Cys Asn Lys His Asn Phe Ser Leu 
        355                 360                 365             


Asn Pro Trp Thr Ser Val Leu Tyr Ser Asp Gly Pro Asn Val Gly Pro 
    370                 375                 380                 


Gly Arg Tyr Leu Ala Leu Lys Leu Ser Asn Gly Ser His Val Ile Gly 
385                 390                 395                 400 


Val Thr Gly Ser Gly Ile Cys Pro Gln Val Ile Lys Glu Pro Ser Met 
                405                 410                 415     


Thr Thr Gly Ile Phe Ser Phe Thr Ile Pro Asp Leu His Glu Glu Leu 
            420                 425                 430         


Ile Gln Ser Ala His Val Leu Asp Pro Val Phe Tyr Ala Leu Gly Met 
        435                 440                 445             


Asn Lys Asp Phe Ser Thr Thr Leu His Ser Ser Ser Asn His Glu Thr 
    450                 455                 460                 


Asn Val Ser Glu Ser Leu Trp His Ile Gly Leu Pro Ser Phe Ser Phe 
465                 470                 475                 480 


Ile Asn Pro Leu Gly Trp Ile Arg Asp Leu Thr Ser Trp Ala Ala Trp 
                485                 490                 495     


Leu Gly Gly Ile Leu Tyr Leu Ala Thr Leu Ile Val Phe Leu Val Arg 
            500                 505                 510         


Thr Leu Thr Arg Lys Ile Lys Tyr Gly Arg 
        515                 520         


<210>  287
<211>  523
<212>  PRT
<213>  Southwest carbovirus

<400>  287

Met Ile Ser Phe Asn Leu Thr Leu Leu Thr Leu Val Leu Gly Pro Gln 
1               5                   10                  15      


Arg Gly Asp Gln Ser Arg Pro Arg Ser Ser His Leu Ala Arg Gln Leu 
            20                  25                  30          


Gln Ser Arg Leu Leu Leu Tyr Leu Thr Phe Ile Leu Ile Cys Leu Thr 
        35                  40                  45              


Ile Pro Gly Thr Thr Ser Glu Cys Asn Ile Thr Thr Asn Gly Leu His 
    50                  55                  60                  


Cys Asn Leu Thr Ser Thr Pro Thr Arg Ile Ser Leu Asn Trp Thr Phe 
65                  70                  75                  80  


Pro Cys Asp Asp Phe Asn Gln Asp Asn His Gln Pro Ala Arg Cys Asn 
                85                  90                  95      


Ile Thr Leu Lys Thr His Asp Pro Thr Pro Leu His Ala Lys Ala Glu 
            100                 105                 110         


Lys Cys Tyr Ile Tyr Thr Cys Thr Thr Ser Phe Gly Phe Trp Gly Val 
        115                 120                 125             


Tyr Ser Glu Ser Arg Glu Val Thr Arg Thr Leu His Arg Asn Gly Cys 
    130                 135                 140                 


Glu Phe Leu Asp Glu Ile Pro Glu Asp Pro Tyr Thr Cys Asn Tyr Trp 
145                 150                 155                 160 


Trp Cys Lys Tyr Asn Val Lys Thr Glu Arg Cys Leu Cys Leu Thr Glu 
                165                 170                 175     


Asn Ile Thr Val Val Ala Leu Pro Asn Gly His Leu Tyr Cys Ser Phe 
            180                 185                 190         


Glu Asp Cys Ser Met Leu Ser Ala Gln Leu Lys Ile Gln Tyr Thr Pro 
        195                 200                 205             


Thr Leu Thr Lys Val Leu Ile Leu Asp Asn Val Thr His Thr Asn Ala 
    210                 215                 220                 


Thr Tyr Ala Asn Gln Pro Ala Thr Ile Ile Asn Gly Thr Arg Val Met 
225                 230                 235                 240 


Ile His Ser Leu His Lys Glu Tyr Thr Ile Val Asn Tyr Thr Leu Asn 
                245                 250                 255     


Asp Thr Ser Ile Asp Gly Gln Cys Glu Ala Ala Ser Ser Thr Arg Arg 
            260                 265                 270         


Arg Arg Asp Ala Ser Gln Gly Tyr Thr Ile Asp Ser Ile Gly His Leu 
        275                 280                 285             


Leu Tyr Pro Gly Phe Glu Ala Cys Arg Leu Leu Arg Thr Leu Leu Pro 
    290                 295                 300                 


Ala Ile Ala Leu Gln Pro Leu Leu Asp His Thr Leu Leu Leu Gln Ala 
305                 310                 315                 320 


Trp Phe Lys Asn Asp Ser Ile Ala Gly Arg Ile Val Ser Asp Thr Ala 
                325                 330                 335     


Leu Val Trp Thr Cys Glu Arg Val Asp Cys Gln Leu Lys Asn Leu Ser 
            340                 345                 350         


Ser Thr Ser Leu Tyr Phe Pro Val Gln Cys Asn Asp Lys Asn Phe Ser 
        355                 360                 365             


Leu Asn Pro Trp Thr Asn Val Leu Tyr Ser Asp Gly Pro Asp Val Gly 
    370                 375                 380                 


Pro Gly Arg Tyr Leu Ala Leu Lys Ile Ala Asn Gly Ser His Ile Thr 
385                 390                 395                 400 


Gly Val Thr Gly Ser Gly Ile Cys Pro Gln Val Ile Glu Glu Pro Ser 
                405                 410                 415     


Met Thr Thr Gly Ile Phe Ser Phe Thr Ile Pro Asp Leu His Glu Asp 
            420                 425                 430         


Leu Ile Gln Ser Val His Ile Leu Asp Pro Val Phe Tyr Ala Leu Gly 
        435                 440                 445             


Met Arg Arg Asp Phe Ser Ala Thr Leu His Ser Ser Thr Asn His Glu 
    450                 455                 460                 


Thr Asn Thr Ser Glu Thr Leu Trp His Ile Gly Leu Pro Ser Phe Ser 
465                 470                 475                 480 


Phe Leu Asn Pro Leu Gly Trp Ile Arg Asp Leu Thr Ser Trp Ala Ala 
                485                 490                 495     


Trp Leu Gly Gly Ile Leu Tyr Leu Val Thr Ile Val Ile Phe Leu Ile 
            500                 505                 510         


Arg Thr Leu Thr Arg Arg Val Lys Tyr Gly Arg 
        515                 520             


<210>  288
<211>  503
<212>  PRT
<213>  Mammalian 1 orthobornavirus

<400>  288

Met Gln Leu Ser Met Ser Phe Leu Ile Gly Phe Gly Thr Leu Val Leu 
1               5                   10                  15      


Ala Leu Ser Ala Arg Thr Phe Asp Leu Gln Gly Leu Ser Cys Asn Thr 
            20                  25                  30          


Asp Ser Thr Pro Gly Leu Ile Asp Leu Glu Ile Arg Arg Leu Cys His 
        35                  40                  45              


Thr Pro Thr Glu Asn Val Ile Ser Cys Glu Val Arg Tyr Leu Asn His 
    50                  55                  60                  


Thr Thr Ile Asn Leu Pro Ala Val His Thr Ser Cys Leu Lys Tyr His 
65                  70                  75                  80  


Cys Lys Thr Tyr Trp Gly Phe Phe Gly Ser Tyr Ser Ala Asp Arg Ile 
                85                  90                  95      


Ile Asn Arg Tyr Thr Gly Thr Val Lys Gly Cys Leu Asn Asn Ser Ala 
            100                 105                 110         


Pro Glu Asp Pro Phe Glu Cys Asn Trp Phe Tyr Cys Cys Ser Ala Ile 
        115                 120                 125             


Thr Thr Glu Ile Cys Arg Cys Ser Ile Thr Asn Val Thr Val Ala Val 
    130                 135                 140                 


Gln Thr Phe Pro Pro Phe Met Tyr Cys Ser Phe Ala Asp Cys Ser Thr 
145                 150                 155                 160 


Val Ser Gln Gln Glu Leu Glu Ser Gly Lys Ala Met Leu Ser Asp Gly 
                165                 170                 175     


Ser Thr Leu Thr Tyr Thr Pro Tyr Ile Leu Gln Ser Glu Val Val Asn 
            180                 185                 190         


Lys Thr Leu Asn Gly Thr Ile Leu Cys Asn Ser Ser Ser Lys Ile Val 
        195                 200                 205             


Ser Phe Asp Glu Phe Arg Arg Ser Tyr Ser Leu Ala Asn Gly Ser Tyr 
    210                 215                 220                 


Gln Ser Ser Ser Ile Asn Val Thr Cys Val Asn Tyr Thr Ser Ser Cys 
225                 230                 235                 240 


Arg Pro Arg Leu Lys Arg Arg Arg Arg Asp Thr Gln Gln Ile Glu Tyr 
                245                 250                 255     


Leu Val His Lys Leu Arg Pro Thr Leu Lys Asp Ala Trp Glu Asp Cys 
            260                 265                 270         


Glu Ile Leu Gln Ser Leu Leu Leu Gly Val Phe Gly Thr Gly Ile Ala 
        275                 280                 285             


Ser Ala Ser Gln Phe Leu Arg Gly Trp Leu Asn His Pro Asp Ile Ile 
    290                 295                 300                 


Gly Tyr Ile Val Asn Gly Val Gly Val Val Trp Gln Cys His Arg Val 
305                 310                 315                 320 


Asn Val Thr Phe Met Ala Trp Asn Glu Ser Thr Tyr Tyr Pro Pro Val 
                325                 330                 335     


Asp Tyr Asn Gly Arg Lys Tyr Phe Leu Asn Asp Glu Gly Arg Leu Gln 
            340                 345                 350         


Thr Asn Thr Pro Glu Ala Arg Pro Gly Leu Lys Arg Val Met Trp Phe 
        355                 360                 365             


Gly Arg Tyr Phe Leu Gly Thr Val Gly Ser Gly Val Lys Pro Arg Arg 
    370                 375                 380                 


Ile Arg Tyr Asn Lys Thr Ser His Asp Tyr His Leu Glu Glu Phe Glu 
385                 390                 395                 400 


Ala Ser Leu Asn Met Thr Pro Gln Thr Ser Ile Ala Ser Gly His Glu 
                405                 410                 415     


Thr Asp Pro Ile Asn His Ala Tyr Gly Thr Gln Ala Asp Leu Leu Pro 
            420                 425                 430         


Tyr Thr Arg Ser Ser Asn Ile Thr Ser Thr Asp Thr Gly Ser Gly Trp 
        435                 440                 445             


Val His Ile Gly Leu Pro Ser Phe Ala Phe Leu Asn Pro Leu Gly Trp 
    450                 455                 460                 


Leu Arg Asp Leu Leu Ala Trp Ala Ala Trp Leu Gly Gly Val Leu Tyr 
465                 470                 475                 480 


Leu Ile Ser Leu Cys Val Ser Leu Pro Ala Ser Phe Ala Arg Arg Arg 
                485                 490                 495     


Arg Leu Gly Arg Trp Gln Glu 
            500             


<210>  289
<211>  503
<212>  PRT
<213>  Mammalian 2 orthobornavirus

<400>  289

Met Gln Ser Thr Gln His Ser Met Ser Phe Pro Ile Val Cys Val Ile 
1               5                   10                  15      


Leu Gly Ser Val Leu Leu Val Gln Thr Phe Glu Leu Arg Gly Leu Arg 
            20                  25                  30          


Cys Asn Thr Asp Ser Thr Pro Ala Leu Val Asp Leu Glu Ile Arg Arg 
        35                  40                  45              


Leu Cys His Thr Pro Ser Glu Asn Val Ile Ser Cys Glu Val Ser Tyr 
    50                  55                  60                  


Tyr Asn His Ser Gln Gln Ser Leu Glu Ala Arg His Thr Ser Cys Tyr 
65                  70                  75                  80  


Lys Tyr His Cys Lys Thr Tyr Trp Gly Phe Phe Gly Ser Tyr Ser Ala 
                85                  90                  95      


Asp Arg Leu Val Ser Arg Tyr Thr Gly Ala Phe Asn Val Cys Asn Asn 
            100                 105                 110         


Gly Ser Phe Pro Asp Asp Pro Tyr Glu Cys Asn Trp Tyr Tyr Cys Cys 
        115                 120                 125             


Ser Ala Leu Thr Thr Glu Ile Cys Arg Cys Ser Ile Asn Asn Val Thr 
    130                 135                 140                 


Val Ala Val Arg Thr Phe Pro Pro Phe Met Tyr Cys Ser Phe Ala Asp 
145                 150                 155                 160 


Cys Ser Thr Val Ser Gln Leu Glu Leu Thr Thr Gly Phe Ala Ser Leu 
                165                 170                 175     


Ser Asp Gly Ser Val Leu Glu Phe Glu Pro Trp Asn Ile Ser Lys Glu 
            180                 185                 190         


Leu Ile Asn Gly Thr Phe Asn Gly Thr Ile Leu Cys Asn Ser Ser Ser 
        195                 200                 205             


Lys Ile Ile Ser Phe Asp Glu Phe Arg Arg Ser Tyr Ser Leu Val Asn 
    210                 215                 220                 


Gly Thr Tyr Met Ser Ser Ser Ile Asn Ile Thr Cys Ser Ser Tyr Asn 
225                 230                 235                 240 


Gly Thr Cys Arg Ala Lys Pro Arg Lys Lys Arg Asp Leu Ser Gln Ile 
                245                 250                 255     


Glu Tyr Leu Val His Lys Leu Arg Pro Thr Leu Arg Asp Ala Trp Glu 
            260                 265                 270         


Asp Cys Glu Ile Leu Gln Ser Leu Leu Leu Gly Val Phe Gly Thr Gly 
        275                 280                 285             


Met Ala Ser Ala Ser Gln Phe Leu Arg Glu Trp Leu Asn Gln Thr Asn 
    290                 295                 300                 


Ile Val Gly Tyr Val Val Asn Gly Val Gly Val Val Trp Gln Cys Asp 
305                 310                 315                 320 


Trp Val Asn Val Ser Phe Leu Pro Trp Asn Glu Ser Thr Tyr Tyr Pro 
                325                 330                 335     


Pro Val Asn Phe Ser Asn Ser Arg Leu Tyr Leu Asn Asp Glu Ser Arg 
            340                 345                 350         


Leu Gln Thr Ser Thr Pro Glu Ala Arg Pro Gly Leu Lys Arg Val Leu 
        355                 360                 365             


Trp Phe Gly Arg Tyr Phe Leu Gly Thr Val Gly Ser Gly Val Lys Pro 
    370                 375                 380                 


Arg Arg Ile Arg Tyr Asn Arg Thr Ser His Asp Phe His Leu Gln Asp 
385                 390                 395                 400 


Phe Asp Ala Ser Leu Asn Leu Thr Pro Ser Ile Asn Leu Ala Thr Gly 
                405                 410                 415     


His Glu Thr Asp Pro Ile Asn His Ala Phe Gly Thr Gln Ala Asn Leu 
            420                 425                 430         


Leu Pro Tyr Thr Arg Ser Asn Asn Ile Thr Ser Thr Asp Thr Gly Ser 
        435                 440                 445             


Gly Trp Val His Ile Gly Leu Pro Ser Phe Ala Phe Leu Asn Pro Leu 
    450                 455                 460                 


Gly Trp Leu Arg Asp Ile Phe Ser Trp Ala Ala Trp Ile Gly Gly Ile 
465                 470                 475                 480 


Leu Tyr Leu Ile Thr Leu Cys Ile Ser Leu Pro Ala Ser Phe Ala Arg 
                485                 490                 495     


Arg Arg Arg Leu Gly Arg Trp 
            500             


<210>  290
<211>  511
<212>  PRT
<213>  Passeriform 1 orthobornavirus

<400>  290

Met Arg Ser Arg Ala Ser Thr Gln Ser Met Leu Pro Ser Thr Phe Phe 
1               5                   10                  15      


Leu Ile Gly Cys Gly Thr Leu Val Leu Val Arg Leu His Leu Ile Ser 
            20                  25                  30          


Ala Pro Gln Ala Leu Lys Cys Asn Thr Asp Ser Thr Pro Ala Leu Ile 
        35                  40                  45              


Asp Leu Glu Ile Arg Arg Leu Cys His Asn Lys Thr Glu Asp Val Val 
    50                  55                  60                  


Pro Cys Glu Val Arg Tyr Arg Asn His Thr Thr Thr Glu Leu Ser Ala 
65                  70                  75                  80  


Val His Ile Ser Cys Tyr Lys Tyr His Cys Lys Thr Tyr Trp Gly Phe 
                85                  90                  95      


Phe Gly Ser Tyr Ser Ala Asp Arg Leu Ile Asn Arg Tyr Leu Gly Ser 
            100                 105                 110         


Ala Ser Ser Cys Ile Asn Thr Ser Ser Glu Asp Pro Phe Lys Cys Thr 
        115                 120                 125             


Trp His Tyr Cys Cys Ser Ala Arg Val Thr Glu Ile Cys Arg Cys Ser 
    130                 135                 140                 


Ile Ser Asn Val Thr Val Ala Val Lys Ser Phe Pro Pro Phe Met Tyr 
145                 150                 155                 160 


Cys Ser Phe Ser Asp Cys Ser Thr Val Ser Glu Ser Glu Leu Arg Leu 
                165                 170                 175     


Gly Arg Ala Asn Leu Ser Asp Gly Ser Tyr Leu Leu Phe Asp Gln Tyr 
            180                 185                 190         


Asn Ile Ser Ser Asp Ile Ile Asn Gly Thr Phe Asn Gly Thr Ile Leu 
        195                 200                 205             


Cys Asn Ser Thr Ser Lys Val Val Ser Phe Asp Glu Phe Arg Arg Ser 
    210                 215                 220                 


Tyr Pro Leu Lys Asn Trp Thr Tyr Thr Ser Glu Thr Leu Asn Val Thr 
225                 230                 235                 240 


Cys Asn Gly Thr Tyr Phe Ser Asn Cys Ser Gly Lys Thr Arg Lys Lys 
                245                 250                 255     


Arg Asp Thr Pro Gln Ile Glu Tyr Leu Val His Lys Leu Arg Pro Thr 
            260                 265                 270         


Leu Arg Asp Ala Trp Glu Asp Cys Glu Ile Leu Gln Ser Leu Leu Leu 
        275                 280                 285             


Gly Val Phe Ala Asn Gly Met Ala Ser Ser Ser Arg Phe Leu Arg Glu 
    290                 295                 300                 


Trp Leu Asn His Ser Asp Ile Val Gly Tyr Val Val Asn Gly Ile Gly 
305                 310                 315                 320 


Val Val Trp Gln Cys Asn Arg Val Asn Ile Thr Phe Leu Pro Trp Asn 
                325                 330                 335     


Glu Ser Thr Tyr Tyr Pro Pro Val Lys Ala Glu Ser Lys Leu Tyr Tyr 
            340                 345                 350         


Leu Asn Glu Glu Gly Arg Leu Gln Thr Ser Thr Pro Glu Ala Arg Pro 
        355                 360                 365             


Gly Leu Lys Arg Ile Phe Phe His Glu Arg Phe Tyr Leu Gly Thr Val 
    370                 375                 380                 


Gly Ser Gly Leu Arg Pro Lys Arg Val Lys Tyr Asn Arg Ser Ser His 
385                 390                 395                 400 


Asp Tyr His Leu Asn Glu Phe Glu Trp Ser Leu Asn Val Thr Pro Val 
                405                 410                 415     


Val Asn Ile Ile Val Gly His Glu Thr Asn Pro Ile Asn His Ala Tyr 
            420                 425                 430         


Gly Thr Gln Ser Asp Leu Leu Pro Tyr Thr Arg Ser Thr Asn Leu Thr 
        435                 440                 445             


Ser Thr Asp Thr Gly Ser Gly Trp Val His Ile Gly Leu Pro Ser Phe 
    450                 455                 460                 


Ala Phe Ile Asn Pro Leu Gly Trp Ile Arg Asp Ile Leu Ser Trp Ala 
465                 470                 475                 480 


Ala Trp Leu Gly Gly Ile Leu Tyr Leu Ile Thr Leu Cys Ile Ser Leu 
                485                 490                 495     


Pro Ala Leu Phe Met Arg Arg Arg Arg Leu Gly Arg Trp Arg Glu 
            500                 505                 510     


<210>  291
<211>  500
<212>  PRT
<213>  Passeriform 2 orthobornavirus

<400>  291

Met Gln His Leu Met Ser Ser His Ile Ala Phe Gly Ile Leu Val Trp 
1               5                   10                  15      


Gly Leu Leu Asp Leu Thr Phe Ala Leu Thr Ala Leu Lys Cys Asn Thr 
            20                  25                  30          


Asp Ser Thr Pro Thr Leu Ile Asp Leu Asp Ile Arg Arg Leu Cys His 
        35                  40                  45              


Asn Arg Thr Asp His Val Val Ser Cys Glu Val Ser Tyr Arg Asn His 
    50                  55                  60                  


Thr Val Leu Asp Ile Arg Ala Asn His Val Ser Cys Phe Lys Tyr His 
65                  70                  75                  80  


Cys Lys Thr Tyr Trp Gly Phe Phe Gly Ser Tyr Ser Ser Asp Arg Leu 
                85                  90                  95      


Ile Asn Arg Tyr Leu Gly Asp Ala Ser Leu Cys Ser Asn Glu Thr Lys 
            100                 105                 110         


Glu Asp Pro Phe Val Cys Asn Trp Tyr Tyr Cys Cys Thr Ala Gln Val 
        115                 120                 125             


Thr Glu Ile Cys Arg Cys Thr Thr Asn Asn Val Thr Ile Ala Val Lys 
    130                 135                 140                 


Thr Phe Pro Pro Phe Val Tyr Cys Ser Phe Ala Asp Cys Ser Thr Val 
145                 150                 155                 160 


Asn Glu Arg Asp Leu Ala Gln Gly Arg Ala Asn Leu Ser Asp Gly Ser 
                165                 170                 175     


Tyr Leu Leu Phe Ser Asn Leu Thr Ile Ser Ser Asp Trp Thr Asn Gly 
            180                 185                 190         


Thr Phe Asn Gly Thr Ile Leu Cys Asn Ser Thr Ser Ser Val Val Ser 
        195                 200                 205             


Ile Asp Ala Phe Arg Arg Ala Tyr Pro Leu Arg Asn Cys Thr Tyr Thr 
    210                 215                 220                 


Ser Glu Thr Leu Asn Ile Thr Cys Gln Asn Cys Ser Glu Pro Cys Arg 
225                 230                 235                 240 


Ser Arg Arg Arg Lys Arg Asp Leu Pro Glu Met Gln Tyr Leu Val His 
                245                 250                 255     


Lys Leu Arg Pro Thr Leu Ala Asp Ala Trp Glu Asp Cys Glu Ile Leu 
            260                 265                 270         


Gln Ser Leu Ile Leu Gly Ile Phe Gly Ser Gly Met Thr Gly Ser Ser 
        275                 280                 285             


Gln Phe Leu Arg Glu Trp Leu Asn His Ser Asp Ile Val Gly Tyr Ile 
    290                 295                 300                 


Val Arg Gly Ile Gly Val Val Trp Gln Cys His Lys Val Asn Ile Ser 
305                 310                 315                 320 


Phe Leu Pro Trp Asn Glu Ser Thr Tyr Tyr Pro Pro Val Asn Ala Ser 
                325                 330                 335     


Gly Glu Arg Leu Tyr Leu Asn Asp Glu Gly Arg Leu Gln Thr Asn Thr 
            340                 345                 350         


Pro Glu Ala Arg Pro Gly Leu Lys Arg Ile Phe Trp His Glu Lys Tyr 
        355                 360                 365             


Tyr Leu Gly Thr Val Gly Ser Asp Ile Lys Pro Lys Arg Val Lys Tyr 
    370                 375                 380                 


Asn Arg Thr Ser His Asp Tyr His Leu Ser Glu Phe Glu Trp Ala Leu 
385                 390                 395                 400 


Asn Ile Thr Pro Ser Ile Asn Ile Met Ala Gly His Glu Thr Asn Pro 
                405                 410                 415     


Ile Asn His Ala Tyr Gly Thr Gln Ser Asp Leu Leu Pro Tyr Thr Arg 
            420                 425                 430         


Ser Ser Asn Ile Thr Ser Thr Asp Thr Gly Ser Gly Trp Val His Ile 
        435                 440                 445             


Gly Leu Pro Ser Phe Ala Phe Ile Asn Pro Leu Gly Trp Ile Arg Asp 
    450                 455                 460                 


Ile Met Ser Trp Ala Ala Trp Ile Gly Gly Ile Leu Tyr Leu Ile Thr 
465                 470                 475                 480 


Leu Cys Ile Ser Leu Pro Ala Leu Phe Val Arg Arg Arg Arg Leu Gly 
                485                 490                 495     


Arg Trp Arg Glu 
            500 


<210>  292
<211>  499
<212>  PRT
<213>  Psittaciform 1 orthobornavirus

<400>  292

Met Leu Pro Leu Met Cys Phe Pro Ile Val Phe Gly Thr Leu Val Leu 
1               5                   10                  15      


Ala Leu Leu Asp Leu Thr Ser Gly Leu Gln Ala Leu Arg Cys Asn Thr 
            20                  25                  30          


Asp Ser Thr Pro Ala Leu Ile Asp Leu Glu Ile His Arg Leu Cys His 
        35                  40                  45              


Asn Arg Thr Glu His Val Val Pro Cys Glu Val Ser Tyr Arg Asn His 
    50                  55                  60                  


Thr Val Ile Glu Leu Ser Ala Gln His Ile Ser Cys Tyr Lys Tyr His 
65                  70                  75                  80  


Cys Lys Thr Tyr Trp Gly Phe Phe Gly Ser Tyr Ser Ala Asp Arg Leu 
                85                  90                  95      


Ile Ser Arg Phe Thr Gly Asp Val Gln Gln Cys Ile Asn Glu Thr Gln 
            100                 105                 110         


Glu Asp Pro Phe Val Cys Asn Trp Tyr Tyr Cys Cys Ser Ala Gln Ile 
        115                 120                 125             


His Glu Ile Cys Arg Cys Ser Ser Ser Asn Val Thr Val Ala Val Lys 
    130                 135                 140                 


Thr Ile Pro Pro Phe Met Tyr Cys Ser Phe Ala Asp Cys Ser Thr Val 
145                 150                 155                 160 


Ser Pro Gln Glu Leu Ser Glu Gly Lys Ala Ser Leu Ser Asp Gly Ser 
                165                 170                 175     


Phe Leu Arg Phe Gln Gln Thr Asn Ile Thr Ser Ser Thr Val Asn Gln 
            180                 185                 190         


Thr Leu Asn Gly Thr Ile Leu Cys Asn Gln Ser Pro Ile Val Ser Phe 
        195                 200                 205             


Asp Glu Phe Arg Arg Ser Tyr Gly Leu Thr Asn Gly Thr Tyr Thr Gly 
    210                 215                 220                 


Asp Thr Ile Ser Ile Ser Cys Asn Ile Thr Ala Ala Lys Cys Pro Lys 
225                 230                 235                 240 


Ser Arg Arg Lys Arg Asp Leu Ser Gln Ile Gln Tyr Leu Val His Thr 
                245                 250                 255     


Leu Arg Pro Thr Leu Arg Asp Ala Trp Glu Asp Cys Glu Leu Leu Gln 
            260                 265                 270         


Ser Ile Leu Leu Glu Leu Phe Gly Ser Gly Thr Thr Ser Ser Ser Arg 
        275                 280                 285             


Phe Leu Arg Ser Trp Leu Asn Ser Thr Asp Ile Val Gly Tyr Val Val 
    290                 295                 300                 


Asn Gly Val Gly Val Ile Trp Gln Cys Glu Pro Thr Asn Val Thr Phe 
305                 310                 315                 320 


Leu Pro Trp Asn Glu Ser Thr Tyr Tyr Pro Pro Val Gln Val Glu Gly 
                325                 330                 335     


Gln Arg Phe Tyr Leu Asn Asp Glu Gly Arg Ile Gln Arg Asn Thr Pro 
            340                 345                 350         


Glu Ala Lys Pro Gly Leu Lys Arg Ile Phe Trp His Glu Arg Tyr Tyr 
        355                 360                 365             


Leu Gly Thr Val Gly Ser Asn Met Lys Pro Lys Arg Val Lys Tyr Asn 
    370                 375                 380                 


Lys Ser Ser His Asp Tyr His Leu Gly Glu Phe Asn Trp Ala Leu Asn 
385                 390                 395                 400 


Ile Thr Pro Gly Ile Asn Leu Gly Val Gly His Glu Thr Asn Pro Ile 
                405                 410                 415     


Asn His Ala Phe Gly Thr Gln Ser Asp Leu Leu Pro Tyr Thr Lys Ser 
            420                 425                 430         


Ser Asn Ile Thr Ser Thr Asp Thr Gly Ser Gly Trp Val His Ile Gly 
        435                 440                 445             


Leu Pro Ser Phe Ala Phe Ile Ser Pro Leu Gly Trp Ile Arg Asp Ile 
    450                 455                 460                 


Leu Ser Trp Ala Ala Trp Leu Gly Gly Ile Leu Tyr Leu Val Thr Ile 
465                 470                 475                 480 


Cys Ile Ser Leu Pro Ala Leu Ile Val Arg Arg Arg Arg Leu Gly Arg 
                485                 490                 495     


Trp Ser Glu 
            


<210>  293
<211>  499
<212>  PRT
<213>  Waterbird 1 orthobornavirus

<400>  293

Met Ser Ser Leu Ile Val Phe Gly Thr Leu Val Leu Asp Leu Ser Ala 
1               5                   10                  15      


Leu Thr Ser Ala Phe Gln Ala Leu Lys Cys Asn Thr Asp Ser Thr Pro 
            20                  25                  30          


Thr Leu Ile Asp Leu Glu Ile Arg His Leu Cys His Asn Ser Thr Glu 
        35                  40                  45              


Asn Val Ile Ser Cys Glu Val Ser Tyr Cys Asn His Thr Ser Thr Glu 
    50                  55                  60                  


Val Pro Ala Thr His Ile Ser Cys Phe Lys Tyr His Cys Lys Thr Tyr 
65                  70                  75                  80  


Trp Gly Phe Phe Gly Ser Tyr Ser Ala Asp Arg Leu Ile Asn Arg Tyr 
                85                  90                  95      


Thr Gly Gln Pro Arg Leu Cys Ile Asn Thr Thr Gly Glu Asp Pro Phe 
            100                 105                 110         


Val Cys Asn Trp Tyr Tyr Cys Cys Ser Ala Ile Val Asn Glu Ile Cys 
        115                 120                 125             


Arg Cys Ser Val Ala Asn Val Thr Ile Val Val Arg Thr Phe Pro Pro 
    130                 135                 140                 


Phe Ala Tyr Cys Ser Phe Ala Asp Cys Ser Thr Val Ser Glu Ser Glu 
145                 150                 155                 160 


Leu Asn Arg Gly Arg Ala Asn Leu Ser Asp Gly Ser Phe Leu Leu Phe 
                165                 170                 175     


Thr Pro Gln Asn Ile Thr Phe Asp Ala Val Asn Ile Thr Leu Asn Gly 
            180                 185                 190         


Thr Val Met Cys Asn Gln Ser Ser Lys Val Val Ser Phe Asp Glu Phe 
        195                 200                 205             


Arg Arg Ser Tyr Pro Leu Val Asn Gly Thr Tyr Cys Ser Ser Thr Leu 
    210                 215                 220                 


Asn Ile Thr Cys Ser Asn Ile Ser Gly Thr Cys Arg Gln Arg Ser Lys 
225                 230                 235                 240 


Arg Thr Arg Arg Asp Leu Ser Gln Met Glu Tyr Leu Val His Lys Leu 
                245                 250                 255     


Arg Pro Thr Leu Arg Asp Ala Trp Glu Asp Cys Glu Ile Leu Gln Ser 
            260                 265                 270         


Leu Leu Leu Gly Val Phe Gly Ser Gly Leu Thr Ser Ala Ser Arg Phe 
        275                 280                 285             


Leu Arg Glu Trp Leu Asn His Thr Asp Ile Val Gly Tyr Val Val Asn 
    290                 295                 300                 


Gly Ile Gly Ile Val Trp Gln Cys Gln Arg Val Glu Asn Val Thr Phe 
305                 310                 315                 320 


Met Pro Trp Asn Glu Ser Thr Tyr Tyr Pro Pro Val Lys Val Asp Gly 
                325                 330                 335     


Arg Arg Leu Tyr Leu Thr Glu Glu Gly Arg Leu Gln Thr Asn Thr Pro 
            340                 345                 350         


Glu Ala Arg Pro Gly Leu Lys Arg Ile Phe Trp His Glu Arg Leu Tyr 
        355                 360                 365             


Leu Gly Thr Val Gly Ser Gly Leu Arg Pro Arg Arg Val Lys Tyr Asn 
    370                 375                 380                 


Arg Ser Ser His Asp Tyr His Leu Asp Glu Phe Asn Trp Arg Leu Asn 
385                 390                 395                 400 


Leu Thr Pro Ser Ile Asn Ile Leu Thr Gly His Glu Thr Asn Pro Ile 
                405                 410                 415     


Asn His Ala Tyr Gly Thr Gln Ser Asn Leu Leu Pro Tyr Thr Arg Ser 
            420                 425                 430         


Asn Asn Ile Thr Ser Thr Asp Thr Gly Ser Gly Trp Val His Ile Gly 
        435                 440                 445             


Leu Pro Ser Phe Ala Phe Ile Asn Pro Leu Gly Trp Ile Arg Asp Ile 
    450                 455                 460                 


Leu Ser Trp Ala Ala Trp Ile Gly Gly Ile Leu Tyr Leu Ile Thr Leu 
465                 470                 475                 480 


Cys Ile Ser Leu Pro Ala Leu Phe Thr Arg Arg Arg Arg Leu Gly Arg 
                485                 490                 495     


Trp Lys Glu 
            


<210>  294
<211>  499
<212>  PRT
<213>  Elapid 1 orthobornavirus

<400>  294

Met Leu Pro Ser Met Cys Ile Leu Ile Gly Ser Gly Met Leu Glu Leu 
1               5                   10                  15      


Val His Leu Val Gln Thr Ser Glu Leu Gln Ala Leu Asn Cys Asp Thr 
            20                  25                  30          


Arg Ser Ser Pro Ala Leu Ile Asp Leu Glu Ile Arg Arg Leu Cys His 
        35                  40                  45              


Lys Thr Thr Glu Asn Val Val Ser Cys Glu Val Ser Tyr Gln Asn His 
    50                  55                  60                  


Thr Val Glu Glu Val Lys Ala Thr Leu Val Ser Cys Tyr Ser Tyr Arg 
65                  70                  75                  80  


Cys Thr Thr Tyr Trp Gly Phe Phe Gly Ser Tyr Ser Ala Asp Lys Met 
                85                  90                  95      


Thr Phe Arg Tyr Thr Gly Asn Ala Thr Thr Cys Asn Asn Gln Thr Val 
            100                 105                 110         


Glu Glu Pro Tyr Ile Cys Asn Trp Tyr Tyr Cys Cys Ser Lys Ala Val 
        115                 120                 125             


Asn Thr Ile Cys Arg Cys Thr Asn Asn Asn Val Thr Val Val Ile Lys 
    130                 135                 140                 


Ser Ala Pro Pro Tyr Met Tyr Cys Ser Phe Gly Asp Cys Ser Thr Val 
145                 150                 155                 160 


Thr Lys Arg Glu Ile Glu Arg Gly Leu Ala Lys Leu Ser Asp Gly Ser 
                165                 170                 175     


Leu Leu Tyr Phe Asn Ser Thr Ile Ile Pro Pro Asp Ile Val Asn Thr 
            180                 185                 190         


Ser Ile Asn Gly Ser Val Leu Cys Asn Asn Lys Ser Lys Leu Val Ser 
        195                 200                 205             


Phe Asp Lys Phe Arg Arg Ser Tyr Pro Leu Arg Lys Trp Lys Tyr Asn 
    210                 215                 220                 


Ser Gln Ser Ile Asn Ile Thr Cys Ser Asn Asp Ser Asn Ile Cys Pro 
225                 230                 235                 240 


Ala Lys Arg Arg Lys Arg Asp Leu Ser Gln Val Ser Tyr Ala Leu His 
                245                 250                 255     


Lys Ile Arg Pro Ile Leu Ala Asp Ala Trp Glu Asp Cys Glu Ile Met 
            260                 265                 270         


Gln Ser Leu Ile Leu Gly Met Thr Gly Ser Asn Leu Phe Ser Ser Ser 
        275                 280                 285             


Gln Phe Leu Arg Lys Trp Leu Asn Arg Thr Asp Ile Ile Gly Tyr Val 
    290                 295                 300                 


Val Gly Gly Leu Gly Val Ile Trp Gln Cys Ser Arg Val Asn Val Ser 
305                 310                 315                 320 


Phe Leu Ser Trp Asn Glu Ser Thr Tyr Phe Pro Pro Val Ser Tyr Met 
                325                 330                 335     


Asp Lys Ile Met Tyr Leu Asn Asp Glu Asp Arg Leu Gln Asp Ser Thr 
            340                 345                 350         


Pro Glu Ala Lys Pro Gly Leu Lys Arg Leu Leu Leu His Gly Ser Tyr 
        355                 360                 365             


Phe Leu Gly Thr Val Gly Ser Gly Leu Lys Pro Lys Leu Val Ser Tyr 
    370                 375                 380                 


Asp Arg Ser Thr His Asp Tyr His Leu Asp Glu Phe Asp Ala Ile Phe 
385                 390                 395                 400 


Asn Leu Thr Pro Glu Val Asp Leu Ile Ser Gly His Glu Thr Asn Pro 
                405                 410                 415     


Ile Asn His Ala Phe Gly Thr Gln Ser Gly Leu Leu Pro Tyr Thr Arg 
            420                 425                 430         


Ser Thr Asn Leu Thr Ser Thr Asp Thr Gly Ser Gly Trp Val His Ile 
        435                 440                 445             


Gly Leu Pro Ser Phe Thr Phe Leu Asn Pro Leu Gly Trp Val Arg Asp 
    450                 455                 460                 


Ile Leu Ser Trp Ala Ala Trp Ile Gly Gly Ile Leu Tyr Leu Ile Thr 
465                 470                 475                 480 


Leu Cys Ile Ser Leu Pro Ala Leu Ile Asn Arg Lys Arg Arg Leu Gly 
                485                 490                 495     


Arg Trp Ser 
            


<210>  295
<211>  415
<212>  PRT
<213>  Lloviu cuevavirus

<400>  295

Met Val Pro Thr Tyr Pro Tyr Ser Ser Leu Leu Asp Trp Arg Pro Pro 
1               5                   10                  15      


Pro Asn Thr Leu Pro Trp Ile Leu Asn Leu Val Val Phe Tyr Thr Ile 
            20                  25                  30          


Ala Trp Leu Pro Gly Gly Val Ser Gly Ile Pro Leu Gly Leu Leu Gly 
        35                  40                  45              


Asn Asn Ser Ile Thr Gln Thr Val Val Asp Asn Val Val Cys Lys Glu 
    50                  55                  60                  


His Leu Ala Thr Thr Asp Gln Leu Gln Ala Ile Gly Leu Gly Leu Glu 
65                  70                  75                  80  


Gly Leu Gly Glu His Ala Asp Leu Pro Thr Ala Thr Lys Arg Trp Gly 
                85                  90                  95      


Phe Arg Ser Asp Val Ile Pro Lys Ile Val Gly Tyr Thr Ala Gly Glu 
            100                 105                 110         


Trp Val Glu Asn Cys Tyr Asn Leu Glu Ile Thr Lys Lys Asp Gly His 
        115                 120                 125             


Pro Cys Leu Pro Ser Pro Pro Thr Gly Leu Leu Gly Tyr Pro Arg Cys 
    130                 135                 140                 


Arg Tyr Val His Arg Ala Lys Gly Ala Gly Pro Cys Pro Gly Gly Asn 
145                 150                 155                 160 


Ala Phe His Lys His Gly Ser Phe Phe Leu Tyr His Gly Met Ala Ser 
                165                 170                 175     


Thr Val Ile Tyr His Gly Val Thr Phe Thr Glu Gly Thr Ile Ala Phe 
            180                 185                 190         


Leu Ile Val Pro Lys Asp Ala Pro Arg Leu Lys Ala Gly Leu Gly Thr 
        195                 200                 205             


Gly Phe Ser His Gln Ala Glu Asn Gln Asn Pro Asn Asn Gln Phe Arg 
    210                 215                 220                 


Thr Thr Thr Leu Asp Tyr Asp Val Met Ser Pro Trp Met Asp Asn Ala 
225                 230                 235                 240 


Thr Phe Phe Phe Arg Ala Arg Glu Asp Thr Ser Met Leu Ile Gln Thr 
                245                 250                 255     


Arg Tyr Pro Pro Ala Asn Leu Glu Leu Val Gln Glu Arg Leu Ala Asn 
            260                 265                 270         


Leu Thr Gly Asp Gln Ala Asp Pro Ser Lys Met Glu Glu Ile Val Ala 
        275                 280                 285             


Glu Val Leu Thr Leu Glu Leu Gly Asp Trp Ser Gly Trp Thr Thr Lys 
    290                 295                 300                 


Lys Thr Ala Val Gln Thr Ile Arg Leu Arg Asn Pro Ser Pro Ala Ser 
305                 310                 315                 320 


Gly Ser Thr Lys Asp Lys Thr Gly Gln Lys Pro Met Thr Asp His Gln 
                325                 330                 335     


Glu Phe Ile Leu Gln Pro His Ser Ala Val Gly Gln Pro Cys Leu Trp 
            340                 345                 350         


Asn Ile Leu Arg Thr Pro Gly Arg Asn Pro Ala Arg Arg His Arg Arg 
        355                 360                 365             


Glu Thr Pro Pro Thr Met Ser Ile Thr Ala Ala Pro Gly Ser Gly Tyr 
    370                 375                 380                 


Lys Pro Tyr Ile Gln Ala Ile Pro Leu Val Lys Phe Arg Cys His Trp 
385                 390                 395                 400 


Glu Gly Leu Arg His Val Cys Arg Arg Tyr Pro Ser Trp Val Gln 
                405                 410                 415 


<210>  296
<211>  320
<212>  PRT
<213>  Lloviu cuevavirus

<400>  296

Met Pro Leu Gly Gly Ser Ser Ala Cys Val Ser Ser Ile Pro Leu Leu 
1               5                   10                  15      


Gly Ser Val Ser Asn Asn Ser Ser Ile Gln Glu Leu Glu Thr Ser Ser 
            20                  25                  30          


Lys Ser Ala Thr Glu Leu Thr Thr Pro Ile Asn His Ser Gln Ser Leu 
        35                  40                  45              


Gln Leu Ala Ser Val Thr Asn Thr Pro Thr Pro Thr Thr Gln Ser Lys 
    50                  55                  60                  


Ser Trp Thr Val Asp Tyr Asn Asn Thr Thr Pro Thr Met Asp Pro Thr 
65                  70                  75                  80  


Thr Ile Leu Thr Thr Pro Asp Thr Ala Thr Ile Pro Pro Asn Asn Ser 
                85                  90                  95      


Ser Asp His Asn Ala Thr Thr Thr Ser Lys Thr Arg Arg Arg Arg Gln 
            100                 105                 110         


Val Asn Pro Val Pro Pro Thr Ile Thr Gln Gln Thr Ser Thr Ser Ile 
        115                 120                 125             


Asn Thr Ser His His Pro Asn Met Thr Thr Gln Leu Ala Arg His Pro 
    130                 135                 140                 


Ser Val Gln Thr Arg Met Gln Asn Pro Ser Cys Asn Pro Asn Leu Arg 
145                 150                 155                 160 


Tyr Trp Thr Ser Arg Glu Met Ser Asn Ala Gly Gly Leu Ala Trp Ile 
                165                 170                 175     


Pro Trp Ile Gly Pro Gly Ile Glu Gly Gly Ile Thr Asp Gly Ile Met 
            180                 185                 190         


Glu His Gln Asn Thr Ile Val Cys Gln Leu Arg Glu Leu Ala Asn Thr 
        195                 200                 205             


Thr Thr Lys Ala Leu Gln Leu Phe Leu Arg Ala Thr Thr Glu Leu Arg 
    210                 215                 220                 


Thr Tyr Ser Ile Leu Asn Arg His Ala Ile Asp Phe Leu Leu Gln Arg 
225                 230                 235                 240 


Trp Gly Gly Thr Cys Arg Ile Leu Gly Pro Asn Cys Cys Ile Glu Pro 
                245                 250                 255     


His Asp Trp Ser Ala Asn Ile Thr Ala Glu Ile Asn His Ile Arg Glu 
            260                 265                 270         


Asp Ile Leu Asn His His Glu Ile Gln Pro Ser Gln Asp Pro Ser Phe 
        275                 280                 285             


Trp Thr Gly Trp Gln Gln Trp Ile Pro Thr Gly Ala Ser Ala Leu Gly 
    290                 295                 300                 


Ile Ile Leu Ala Ile Leu Ala Leu Ile Cys Leu Cys Arg Ile Thr Arg 
305                 310                 315                 320 


<210>  297
<211>  662
<212>  PRT
<213>  Mengla dianlovirus

<400>  297

Met Ala Leu Ala Lys Lys Tyr Leu Met Arg Ile Phe Ile Ile Ser His 
1               5                   10                  15      


Tyr Phe Leu Ser Tyr Asn Tyr Gly Phe Phe Leu Pro Ile Val Lys Leu 
            20                  25                  30          


Asp Ile Gln Pro Glu Asn Glu Ile Ile Lys Ser Pro Cys Asn Gly Val 
        35                  40                  45              


Val Lys Lys Thr Glu Asp Ile His Leu Met Ser Leu Thr Leu Thr Gly 
    50                  55                  60                  


Gln Lys Thr Ala Ser Asp Pro Met Ala Ala Ser Lys Arg Trp Ala Phe 
65                  70                  75                  80  


Lys Glu Gly Val Leu Pro Lys Thr Val Ala Phe Thr Glu Gly Glu Glu 
                85                  90                  95      


Ala Lys Asp Cys Phe Asn Ile Ser Ile Val Asp Leu Gln Gly Arg Ser 
            100                 105                 110         


Leu Leu Leu Glu Ala Pro Ser Gly Ile Lys Asp Tyr Pro Arg Cys Lys 
        115                 120                 125             


Ser Ile His His Ile Gln Gly Gln Asn Pro His Ala Lys Gly Asn Val 
    130                 135                 140                 


Leu His Leu Trp Gly Ala Phe Phe Leu Tyr Asp Arg Ile Ala Ser Thr 
145                 150                 155                 160 


Thr Met Phe Lys Asp Lys Val Phe Ala Glu Gly Asn Val Ala Ala Leu 
                165                 170                 175     


Val Ile Asn Lys Thr Val His His Gln Ile Phe Lys Ile Asn Lys Ile 
            180                 185                 190         


Pro Gln Asn Glu Thr Ile Gly Ser Cys Asn His Thr Tyr Trp Arg Ser 
        195                 200                 205             


Asp Ala Gly Asp Gly Phe Asn Thr Thr Leu Ala Val Thr Asn Leu Ala 
    210                 215                 220                 


Tyr Val Leu Ser Ala Asn Glu Ser Thr Lys Ile Phe Lys Gln Met Gln 
225                 230                 235                 240 


Asp Asp Leu Arg Lys Arg Ile Glu Asn Met Thr Ser Ser Asn Leu Thr 
                245                 250                 255     


Thr Leu Ser Pro Glu Ala Ile Ser Asn Ser Ser Asp Ala Asn Ser Ser 
            260                 265                 270         


Ala Thr Ile Ala Tyr Gly Thr Ser Gly Ala Ser Ile Ser Ala Thr Thr 
        275                 280                 285             


Arg Ser Ala Thr Ser Thr Leu Thr Ile Thr Thr Asp Gly Gln Met Ser 
    290                 295                 300                 


Pro Pro Pro Thr Pro Ala Pro Pro Ser Pro Ser Leu Lys Pro Ser Thr 
305                 310                 315                 320 


Asp Asp Ile Lys Thr Pro Thr Val Leu Ser Thr Thr Ser Ser Ser Thr 
                325                 330                 335     


Arg Ser Lys Arg Ser Val Thr Val Ala Lys Gln Ser Ser Ala Asn Pro 
            340                 345                 350         


Thr Gly Lys Gln Arg Gly Arg Gly Arg Lys Gly Pro Ser Thr Gly Thr 
        355                 360                 365             


Leu Thr Glu Glu Gln Ile Glu Arg Val Arg Met Leu Ile Gln Lys Asn 
    370                 375                 380                 


Val Gly Arg Val Asn Tyr Asn Asn Leu Pro Leu Ile Ala Gly Leu Thr 
385                 390                 395                 400 


Ala Leu Lys Lys Lys Arg Gln Val Leu Glu Thr Phe Ser Gly Glu Ile 
                405                 410                 415     


Glu Leu Glu Glu Leu Ile Gly Asp Glu Lys Leu Asp Ser Arg Phe Arg 
            420                 425                 430         


Glu Asn Leu Lys Met Ile Leu Glu Thr Leu Arg Asn Glu Ser Tyr Ser 
        435                 440                 445             


His Phe Glu Leu Asp Ile Pro Lys Thr Ala Ala Leu Lys Ser Pro Glu 
    450                 455                 460                 


Glu Thr Asp Pro Arg Ile His Met Glu Tyr Leu Gly Ser Gly Glu Glu 
465                 470                 475                 480 


Pro Ile Gln Ser Asn Gly Gln Thr Asp Thr Asp Cys Asp Pro Ser Leu 
                485                 490                 495     


Arg Ile Trp Thr Pro Asn Glu Glu Lys Leu Ala Ala Gly Val Ser Trp 
            500                 505                 510         


Ile Pro Tyr Phe Gly Pro Gly Ala Glu Gly Leu Tyr Thr Met Gly Leu 
        515                 520                 525             


Met Gln Asn Gln Asn Asp Val Val Cys Arg Leu Arg Arg Leu Ala Asn 
    530                 535                 540                 


Gln Thr Ala Lys Ser Leu Asp Leu Leu Leu Arg Val Thr Thr Glu Glu 
545                 550                 555                 560 


Arg Thr Tyr Ser Ile Ile Asn Arg His Ala Ile Asp Phe Leu Leu Ala 
                565                 570                 575     


Arg Trp Gly Gly Thr Cys Arg Val Leu Gly Pro Glu Cys Cys Ile Gly 
            580                 585                 590         


Val Glu Asp Leu Thr Lys Asn Ile Thr Asp Gln Ile Gln Gln Met Arg 
        595                 600                 605             


Arg Asp Glu Gln Asp Glu Tyr Glu Gly Trp Gly Lys Gly Gly Asn Trp 
    610                 615                 620                 


Phe Asn Ser Gln Phe Gly Asn Trp Leu Asn Leu Gly Ile Leu Ile Phe 
625                 630                 635                 640 


Leu Phe Leu Gly Ile Ile Ile Ala Leu Ser Cys Val Cys Arg Leu Phe 
                645                 650                 655     


Met Asn Leu Thr Val Tyr 
            660         


<210>  298
<211>  672
<212>  PRT
<213>  Bombali ebolavirus

<400>  298

Met Ile Leu Gln Val Pro Glu Lys Arg His Gln Arg Thr Val Leu Phe 
1               5                   10                  15      


Ile Trp Leu Val Ile Leu Phe Gln Arg Ala Val Ser Val Pro Leu Gly 
            20                  25                  30          


Val Ile His Asn Ser Thr Leu Gln Val Ser Asp Ile Asp Lys Leu Val 
        35                  40                  45              


Cys His Asp Lys Leu Thr Ser Thr Asn Gln Leu Arg Ser Ile Gly Leu 
    50                  55                  60                  


Asn Leu Glu Gly Asn Gly Ile Ala Thr Asp Val Pro Ser Ala Thr Lys 
65                  70                  75                  80  


Arg Trp Gly Phe Arg Ala Gly Val Pro Pro Lys Val Val Gly Tyr Glu 
                85                  90                  95      


Ala Gly Glu Trp Ala Glu Asn Cys Tyr Asn Leu Glu Ile Lys Lys Pro 
            100                 105                 110         


Asp Gly Ser Glu Cys Leu Pro Met Ala Pro Glu Gly Ile Arg Gly Phe 
        115                 120                 125             


Pro Arg Cys Arg Tyr Val His Lys Val Ser Gly Thr Gly Ser Cys Glu 
    130                 135                 140                 


Ser Gly Phe Ala Phe His Lys Glu Gly Ala Phe Phe Leu Tyr Asp Arg 
145                 150                 155                 160 


Leu Ala Ser Thr Ile Ile Tyr Arg Gly Thr Thr Phe Ala Glu Gly Val 
                165                 170                 175     


Val Ala Phe Ile Ile Leu Pro Lys Ala Glu Lys Asn Phe Leu Gln Pro 
            180                 185                 190         


Pro Leu Thr Gln Gly Pro Thr Asn Thr Thr Asn Asp Pro Ser Ser Met 
        195                 200                 205             


Tyr His Ser Thr Thr Leu Glu Tyr Glu Thr Thr Arg Phe Gly Thr Asn 
    210                 215                 220                 


Arg Ser Ala Phe Trp Phe Lys Val Asp Asn Leu Thr Phe Val Gln Leu 
225                 230                 235                 240 


Glu Ser Arg Phe Thr Pro Gln Phe Leu Val Glu Leu Asn Glu Thr Ile 
                245                 250                 255     


Tyr Ile Glu Gly Lys Arg Ser Asn Thr Thr Gly Arg Leu Ile Trp Gln 
            260                 265                 270         


Val Asn Ser Arg Val Asp Thr Asp Val Gly Glu Trp Ala Phe Trp Glu 
        275                 280                 285             


Asn Lys Lys Asn Leu Lys Lys Ser Phe Pro Arg Glu Glu Leu Ser Leu 
    290                 295                 300                 


Ala Ala Val Pro Arg Ala Ala Asp Ser Glu His Asp Thr His Pro Pro 
305                 310                 315                 320 


Glu His Thr Pro Gly Pro Asp Ser Asn Pro Thr Ile Asn Asp Asn Thr 
                325                 330                 335     


Glu Leu Val Thr Glu Asp Pro Ala His Leu Val Gln Leu Gln Arg Gln 
            340                 345                 350         


Gly Arg Lys Glu Ile Leu Pro Thr Pro Ile Pro Gln Ala Ile Glu Arg 
        355                 360                 365             


Glu Pro Pro Ala Ala Gln His Asp Asn Pro Arg Asn Ser Pro Thr Pro 
    370                 375                 380                 


Pro Ser Pro Ile Glu Ser Asp Ile Thr Asp Ser Thr Gln Ala Glu Asp 
385                 390                 395                 400 


Leu Thr His Ala Asp Asp Pro Ser Thr Ile Asn Ser Ala Thr Glu Glu 
                405                 410                 415     


Ser Leu Pro Glu Val Gly Gly Ile Thr Gln Val Pro Arg Asp Pro Glu 
            420                 425                 430         


Asp Pro Arg Ile Thr Leu Ser Thr Pro Pro Thr Ser Gln Pro Glu Gln 
        435                 440                 445             


Pro Ser Asp Asn Thr Met Thr Pro Gly Gln Ile His Ser Glu Ser Ala 
    450                 455                 460                 


Ala Pro Met Gly Glu Arg Ser Ile Asp Gly Pro Gly Leu Leu Thr Asn 
465                 470                 475                 480 


Thr Leu Ala Gly Val Ala Arg Leu Ile Thr Gly Ala Gly Arg Ala Lys 
                485                 490                 495     


Arg Glu Ser Pro Glu Ile Arg Gly Ala Lys Cys Asn Pro Asn Leu His 
            500                 505                 510         


Tyr Trp Thr Thr His Glu Glu Ser Ala Ala Ala Gly Leu Ala Trp Ile 
        515                 520                 525             


Pro Tyr Phe Gly Pro Ala Ala Glu Gly Ile Tyr Thr Glu Gly Leu Met 
    530                 535                 540                 


Gln Asn Gln Asn Glu Leu Ile Cys Gly Leu Arg Gln Leu Ala Asn Glu 
545                 550                 555                 560 


Thr Thr Gln Ala Leu Gln Leu Phe Leu Arg Ser Thr Thr Glu Leu Arg 
                565                 570                 575     


Thr Phe Ser Ile Leu Asn Arg Lys Ala Ile Asp Phe Leu Leu Gln Arg 
            580                 585                 590         


Trp Gly Gly Thr Cys Arg Ile Leu Gly Pro Asp Cys Cys Ile Glu Pro 
        595                 600                 605             


His Asp Trp Thr Lys Asn Ile Thr Asp Arg Ile Asp Gln Ile Ile His 
    610                 615                 620                 


Asp Phe Val Asp Lys Pro Leu Pro Asp Gln Ser Asn Asn Asp Asn Trp 
625                 630                 635                 640 


Trp Thr Gly Trp Arg Gln Trp Ile Pro Ala Gly Ile Gly Val Val Gly 
                645                 650                 655     


Val Ile Ala Ala Phe Ile Ala Leu Ile Cys Ile Cys Lys Ile Ile Cys 
            660                 665                 670         


<210>  299
<211>  676
<212>  PRT
<213>  Bundibugyo ebolavirus

<400>  299

Met Val Thr Ser Gly Ile Leu Gln Leu Pro Arg Glu Arg Phe Arg Lys 
1               5                   10                  15      


Thr Ser Phe Phe Val Trp Val Ile Ile Leu Phe His Lys Val Phe Pro 
            20                  25                  30          


Ile Pro Leu Gly Val Val His Asn Asn Thr Leu Gln Val Ser Asp Ile 
        35                  40                  45              


Asp Lys Leu Val Cys Arg Asp Lys Leu Ser Ser Thr Ser Gln Leu Lys 
    50                  55                  60                  


Ser Val Gly Leu Asn Leu Glu Gly Asn Gly Val Ala Thr Asp Val Pro 
65                  70                  75                  80  


Thr Ala Thr Lys Arg Trp Gly Phe Arg Ala Gly Val Pro Pro Lys Val 
                85                  90                  95      


Val Asn Tyr Glu Ala Gly Glu Trp Ala Glu Asn Cys Tyr Asn Leu Asp 
            100                 105                 110         


Ile Lys Lys Ala Asp Gly Ser Glu Cys Leu Pro Glu Ala Pro Glu Gly 
        115                 120                 125             


Val Arg Gly Phe Pro Arg Cys Arg Tyr Val His Lys Val Ser Gly Thr 
    130                 135                 140                 


Gly Pro Cys Pro Glu Gly Tyr Ala Phe His Lys Glu Gly Ala Phe Phe 
145                 150                 155                 160 


Leu Tyr Asp Arg Leu Ala Ser Thr Ile Ile Tyr Arg Ser Thr Thr Phe 
                165                 170                 175     


Ser Glu Gly Val Val Ala Phe Leu Ile Leu Pro Glu Thr Lys Lys Asp 
            180                 185                 190         


Phe Phe Gln Ser Pro Pro Leu His Glu Pro Ala Asn Met Thr Thr Asp 
        195                 200                 205             


Pro Ser Ser Tyr Tyr His Thr Val Thr Leu Asn Tyr Val Ala Asp Asn 
    210                 215                 220                 


Phe Gly Thr Asn Met Thr Asn Phe Leu Phe Gln Val Asp His Leu Thr 
225                 230                 235                 240 


Tyr Val Gln Leu Glu Pro Arg Phe Thr Pro Gln Phe Leu Val Gln Leu 
                245                 250                 255     


Asn Glu Thr Ile Tyr Thr Asn Gly Arg Arg Ser Asn Thr Thr Gly Thr 
            260                 265                 270         


Leu Ile Trp Lys Val Asn Pro Thr Val Asp Thr Gly Val Gly Glu Trp 
        275                 280                 285             


Ala Phe Trp Glu Asn Lys Lys Asn Phe Thr Lys Thr Leu Ser Ser Glu 
    290                 295                 300                 


Glu Leu Ser Val Ile Phe Val Pro Arg Ala Gln Asp Pro Gly Ser Asn 
305                 310                 315                 320 


Gln Lys Thr Lys Val Thr Pro Thr Ser Phe Ala Asn Asn Gln Thr Ser 
                325                 330                 335     


Lys Asn His Glu Asp Leu Val Pro Glu Asp Pro Ala Ser Val Val Gln 
            340                 345                 350         


Val Arg Asp Leu Gln Arg Glu Asn Thr Val Pro Thr Pro Pro Pro Asp 
        355                 360                 365             


Thr Val Pro Thr Thr Leu Ile Pro Asp Thr Met Glu Glu Gln Thr Thr 
    370                 375                 380                 


Ser His Tyr Glu Pro Pro Asn Ile Ser Arg Asn His Gln Glu Arg Asn 
385                 390                 395                 400 


Asn Thr Ala His Pro Glu Thr Leu Ala Asn Asn Pro Pro Asp Asn Thr 
                405                 410                 415     


Thr Pro Ser Thr Pro Pro Gln Asp Gly Glu Arg Thr Ser Ser His Thr 
            420                 425                 430         


Thr Pro Ser Pro Arg Pro Val Pro Thr Ser Thr Ile His Pro Thr Thr 
        435                 440                 445             


Arg Glu Thr His Ile Pro Thr Thr Met Thr Thr Ser His Asp Thr Asp 
    450                 455                 460                 


Ser Asn Arg Pro Asn Pro Ile Asp Ile Ser Glu Ser Thr Glu Pro Gly 
465                 470                 475                 480 


Pro Leu Thr Asn Thr Thr Arg Gly Ala Ala Asn Leu Leu Thr Gly Ser 
                485                 490                 495     


Arg Arg Thr Arg Arg Glu Ile Thr Leu Arg Thr Gln Ala Lys Cys Asn 
            500                 505                 510         


Pro Asn Leu His Tyr Trp Thr Thr Gln Asp Glu Gly Ala Ala Ile Gly 
        515                 520                 525             


Leu Ala Trp Ile Pro Tyr Phe Gly Pro Ala Ala Glu Gly Ile Tyr Thr 
    530                 535                 540                 


Glu Gly Ile Met His Asn Gln Asn Gly Leu Ile Cys Gly Leu Arg Gln 
545                 550                 555                 560 


Leu Ala Asn Glu Thr Thr Gln Ala Leu Gln Leu Phe Leu Arg Ala Thr 
                565                 570                 575     


Thr Glu Leu Arg Thr Phe Ser Ile Leu Asn Arg Lys Ala Ile Asp Phe 
            580                 585                 590         


Leu Leu Gln Arg Trp Gly Gly Thr Cys His Ile Leu Gly Pro Asp Cys 
        595                 600                 605             


Cys Ile Glu Pro His Asp Trp Thr Lys Asn Ile Thr Asp Lys Ile Asp 
    610                 615                 620                 


Gln Ile Ile His Asp Phe Ile Asp Lys Pro Leu Pro Asp Gln Thr Asp 
625                 630                 635                 640 


Asn Asp Asn Trp Trp Thr Gly Trp Arg Gln Trp Val Pro Ala Gly Ile 
                645                 650                 655     


Gly Ile Thr Gly Val Ile Ile Ala Val Ile Ala Leu Leu Cys Ile Cys 
            660                 665                 670         


Lys Phe Leu Leu 
        675     


<210>  300
<211>  677
<212>  PRT
<213>  Reston ebolavirus

<400>  300

Met Gly Ser Gly Tyr Gln Leu Leu Gln Leu Pro Arg Glu Arg Phe Arg 
1               5                   10                  15      


Lys Thr Ser Phe Leu Val Trp Val Ile Ile Leu Phe Gln Arg Ala Ile 
            20                  25                  30          


Ser Met Pro Leu Gly Ile Val Thr Asn Ser Thr Leu Lys Ala Thr Glu 
        35                  40                  45              


Ile Asp Gln Leu Val Cys Arg Asp Lys Leu Ser Ser Thr Ser Gln Leu 
    50                  55                  60                  


Lys Ser Val Gly Leu Asn Leu Glu Gly Asn Gly Ile Ala Thr Asp Val 
65                  70                  75                  80  


Pro Ser Ala Thr Lys Arg Trp Gly Phe Arg Ser Gly Val Pro Pro Lys 
                85                  90                  95      


Val Val Ser Tyr Glu Ala Gly Glu Trp Ala Glu Asn Cys Tyr Asn Leu 
            100                 105                 110         


Glu Ile Lys Lys Ser Asp Gly Ser Glu Cys Leu Pro Leu Pro Pro Asp 
        115                 120                 125             


Gly Val Arg Gly Phe Pro Arg Cys Arg Tyr Val His Lys Val Gln Gly 
    130                 135                 140                 


Thr Gly Pro Cys Pro Gly Asp Leu Ala Phe His Lys Asn Gly Ala Phe 
145                 150                 155                 160 


Phe Leu Tyr Asp Arg Leu Ala Ser Thr Val Ile Tyr Arg Gly Thr Thr 
                165                 170                 175     


Phe Ala Glu Gly Val Val Ala Phe Leu Ile Leu Ser Glu Pro Lys Lys 
            180                 185                 190         


His Phe Trp Lys Ala Thr Pro Ala His Glu Pro Val Asn Thr Thr Asp 
        195                 200                 205             


Asp Ser Thr Ser Tyr Tyr Met Thr Leu Thr Leu Ser Tyr Glu Met Ser 
    210                 215                 220                 


Asn Phe Gly Gly Asn Glu Ser Asn Thr Leu Phe Lys Val Asp Asn His 
225                 230                 235                 240 


Thr Tyr Val Gln Leu Asp Arg Pro His Thr Pro Gln Phe Leu Val Gln 
                245                 250                 255     


Leu Asn Glu Thr Leu Arg Arg Asn Asn Arg Leu Ser Asn Ser Thr Gly 
            260                 265                 270         


Arg Leu Thr Trp Thr Leu Asp Pro Lys Ile Glu Pro Asp Val Gly Glu 
        275                 280                 285             


Trp Ala Phe Trp Glu Thr Lys Lys Asn Phe Ser Gln Gln Leu His Gly 
    290                 295                 300                 


Glu Asn Leu His Phe Gln Ile Leu Ser Thr His Thr Asn Asn Ser Ser 
305                 310                 315                 320 


Asp Gln Ser Pro Ala Gly Thr Val Gln Gly Lys Ile Ser Tyr His Pro 
                325                 330                 335     


Pro Ala Asn Asn Ser Glu Leu Val Pro Thr Asp Ser Pro Pro Val Val 
            340                 345                 350         


Ser Val Leu Thr Ala Gly Arg Thr Glu Glu Met Ser Thr Gln Gly Leu 
        355                 360                 365             


Thr Asn Gly Glu Thr Ile Thr Gly Phe Thr Ala Asn Pro Met Thr Thr 
    370                 375                 380                 


Thr Ile Ala Pro Ser Pro Thr Met Thr Ser Glu Val Asp Asn Asn Val 
385                 390                 395                 400 


Pro Ser Glu Gln Pro Asn Asn Thr Ala Ser Ile Glu Asp Ser Pro Pro 
                405                 410                 415     


Ser Ala Ser Asn Glu Thr Ile Tyr His Ser Glu Met Asp Pro Ile Gln 
            420                 425                 430         


Gly Ser Asn Asn Ser Ala Gln Ser Pro Gln Thr Lys Thr Thr Pro Ala 
        435                 440                 445             


Pro Thr Thr Ser Pro Met Thr Gln Asp Pro Gln Glu Thr Ala Asn Ser 
    450                 455                 460                 


Ser Lys Pro Gly Thr Ser Pro Gly Ser Ala Ala Gly Pro Ser Gln Pro 
465                 470                 475                 480 


Gly Leu Thr Ile Asn Thr Val Ser Lys Val Ala Asp Ser Leu Ser Pro 
                485                 490                 495     


Thr Arg Lys Gln Lys Arg Ser Val Arg Gln Asn Thr Ala Asn Lys Cys 
            500                 505                 510         


Asn Pro Asp Leu Tyr Tyr Trp Thr Ala Val Asp Glu Gly Ala Ala Val 
        515                 520                 525             


Gly Leu Ala Trp Ile Pro Tyr Phe Gly Pro Ala Ala Glu Gly Ile Tyr 
    530                 535                 540                 


Ile Glu Gly Val Met His Asn Gln Asn Gly Leu Ile Cys Gly Leu Arg 
545                 550                 555                 560 


Gln Leu Ala Asn Glu Thr Thr Gln Ala Leu Gln Leu Phe Leu Arg Ala 
                565                 570                 575     


Thr Thr Glu Leu Arg Thr Tyr Ser Leu Leu Asn Arg Lys Ala Ile Asp 
            580                 585                 590         


Phe Leu Leu Gln Arg Trp Gly Gly Thr Cys Arg Ile Leu Gly Pro Ser 
        595                 600                 605             


Cys Cys Ile Glu Pro His Asp Trp Thr Lys Asn Ile Thr Asp Glu Ile 
    610                 615                 620                 


Asn Gln Ile Lys His Asp Phe Ile Asp Asn Pro Leu Pro Asp His Gly 
625                 630                 635                 640 


Asp Asp Leu Asn Leu Trp Thr Gly Trp Arg Gln Trp Ile Pro Ala Gly 
                645                 650                 655     


Ile Gly Ile Ile Gly Val Ile Ile Ala Ile Ile Ala Leu Leu Cys Ile 
            660                 665                 670         


Cys Lys Ile Leu Cys 
        675         


<210>  301
<211>  676
<212>  PRT
<213>  Sudan ebolavirus

<400>  301

Met Gly Gly Leu Ser Leu Leu Gln Leu Pro Arg Asp Lys Phe Arg Lys 
1               5                   10                  15      


Ser Ser Phe Phe Val Trp Val Ile Ile Leu Phe Gln Lys Ala Phe Ser 
            20                  25                  30          


Met Pro Leu Gly Val Val Thr Asn Ser Thr Leu Glu Val Thr Glu Ile 
        35                  40                  45              


Asp Gln Leu Val Cys Lys Asp His Leu Ala Ser Thr Asp Gln Leu Lys 
    50                  55                  60                  


Ser Val Gly Leu Asn Leu Glu Gly Ser Gly Val Ser Thr Asp Ile Pro 
65                  70                  75                  80  


Ser Ala Thr Lys Arg Trp Gly Phe Arg Ser Gly Val Pro Pro Lys Val 
                85                  90                  95      


Val Ser Tyr Glu Ala Gly Glu Trp Ala Glu Asn Cys Tyr Asn Leu Glu 
            100                 105                 110         


Ile Lys Lys Pro Asp Gly Ser Glu Cys Leu Pro Pro Pro Pro Asp Gly 
        115                 120                 125             


Val Arg Gly Phe Pro Arg Cys Arg Tyr Val His Lys Ala Gln Gly Thr 
    130                 135                 140                 


Gly Pro Cys Pro Gly Asp Tyr Ala Phe His Lys Asp Gly Ala Phe Phe 
145                 150                 155                 160 


Leu Tyr Asp Arg Leu Ala Ser Thr Val Ile Tyr Arg Gly Val Asn Phe 
                165                 170                 175     


Ala Glu Gly Val Ile Ala Phe Leu Ile Leu Ala Lys Pro Lys Glu Thr 
            180                 185                 190         


Phe Leu Gln Ser Pro Pro Ile Arg Glu Ala Val Asn Tyr Thr Glu Asn 
        195                 200                 205             


Thr Ser Ser Tyr Tyr Ala Thr Ser Tyr Leu Glu Tyr Glu Ile Glu Asn 
    210                 215                 220                 


Phe Gly Ala Gln His Ser Thr Thr Leu Phe Lys Ile Asp Asn Asn Thr 
225                 230                 235                 240 


Phe Val Arg Leu Asp Arg Pro His Thr Pro Gln Phe Leu Phe Gln Leu 
                245                 250                 255     


Asn Asp Thr Ile His Leu His Gln Gln Leu Ser Asn Thr Thr Gly Arg 
            260                 265                 270         


Leu Ile Trp Thr Leu Asp Ala Asn Ile Asn Ala Asp Ile Gly Glu Trp 
        275                 280                 285             


Ala Phe Trp Glu Asn Lys Lys Asn Leu Ser Glu Gln Leu Arg Gly Glu 
    290                 295                 300                 


Glu Leu Ser Phe Glu Ala Leu Ser Leu Asn Glu Thr Glu Asp Asp Asp 
305                 310                 315                 320 


Ala Ala Ser Ser Arg Ile Thr Lys Gly Arg Ile Ser Asp Arg Ala Thr 
                325                 330                 335     


Arg Lys Tyr Ser Asp Leu Val Pro Lys Asn Ser Pro Gly Met Val Pro 
            340                 345                 350         


Leu His Ile Pro Glu Gly Glu Thr Thr Leu Pro Ser Gln Asn Ser Thr 
        355                 360                 365             


Glu Gly Arg Arg Val Gly Val Asn Thr Gln Glu Thr Ile Thr Glu Thr 
    370                 375                 380                 


Ala Ala Thr Ile Ile Gly Thr Asn Gly Asn His Met Gln Ile Ser Thr 
385                 390                 395                 400 


Ile Gly Ile Arg Pro Ser Ser Ser Gln Ile Pro Ser Ser Ser Pro Thr 
                405                 410                 415     


Thr Ala Pro Ser Pro Glu Ala Gln Thr Pro Thr Thr His Thr Ser Gly 
            420                 425                 430         


Pro Ser Val Met Ala Thr Glu Glu Pro Thr Thr Pro Pro Gly Ser Ser 
        435                 440                 445             


Pro Gly Pro Thr Thr Glu Ala Pro Thr Leu Thr Thr Pro Glu Asn Ile 
    450                 455                 460                 


Thr Thr Ala Val Lys Thr Val Leu Pro Gln Glu Ser Thr Ser Asn Gly 
465                 470                 475                 480 


Leu Ile Thr Ser Thr Val Thr Gly Ile Leu Gly Ser Leu Gly Leu Arg 
                485                 490                 495     


Lys Arg Ser Arg Arg Gln Thr Asn Thr Lys Ala Thr Gly Lys Cys Asn 
            500                 505                 510         


Pro Asn Leu His Tyr Trp Thr Ala Gln Glu Gln His Asn Ala Ala Gly 
        515                 520                 525             


Ile Ala Trp Ile Pro Tyr Phe Gly Pro Gly Ala Glu Gly Ile Tyr Thr 
    530                 535                 540                 


Glu Gly Leu Met His Asn Gln Asn Ala Leu Val Cys Gly Leu Arg Gln 
545                 550                 555                 560 


Leu Ala Asn Glu Thr Thr Gln Ala Leu Gln Leu Phe Leu Arg Ala Thr 
                565                 570                 575     


Thr Glu Leu Arg Thr Tyr Thr Ile Leu Asn Arg Lys Ala Ile Asp Phe 
            580                 585                 590         


Leu Leu Arg Arg Trp Gly Gly Thr Cys Arg Ile Leu Gly Pro Asp Cys 
        595                 600                 605             


Cys Ile Glu Pro His Asp Trp Thr Lys Asn Ile Thr Asp Lys Ile Asn 
    610                 615                 620                 


Gln Ile Ile His Asp Phe Ile Asp Asn Pro Leu Pro Asn Gln Asp Asn 
625                 630                 635                 640 


Asp Asp Asn Trp Trp Thr Gly Trp Arg Gln Trp Ile Pro Ala Gly Ile 
                645                 650                 655     


Gly Ile Thr Gly Ile Ile Ile Ala Ile Ile Ala Leu Leu Cys Val Cys 
            660                 665                 670         


Lys Leu Leu Cys 
        675     


<210>  302
<211>  676
<212>  PRT
<213>  Tai Forest ebolavirus

<400>  302

Met Gly Ala Ser Gly Ile Leu Gln Leu Pro Arg Glu Arg Phe Arg Lys 
1               5                   10                  15      


Thr Ser Phe Phe Val Trp Val Ile Ile Leu Phe His Lys Val Phe Ser 
            20                  25                  30          


Ile Pro Leu Gly Val Val His Asn Asn Thr Leu Gln Val Ser Asp Ile 
        35                  40                  45              


Asp Lys Phe Val Cys Arg Asp Lys Leu Ser Ser Thr Ser Gln Leu Lys 
    50                  55                  60                  


Ser Val Gly Leu Asn Leu Glu Gly Asn Gly Val Ala Thr Asp Val Pro 
65                  70                  75                  80  


Thr Ala Thr Lys Arg Trp Gly Phe Arg Ala Gly Val Pro Pro Lys Val 
                85                  90                  95      


Val Asn Tyr Glu Ala Gly Glu Trp Ala Glu Asn Cys Tyr Asn Leu Ala 
            100                 105                 110         


Ile Lys Lys Val Asp Gly Ser Glu Cys Leu Pro Glu Ala Pro Glu Gly 
        115                 120                 125             


Val Arg Asp Phe Pro Arg Cys Arg Tyr Val His Lys Val Ser Gly Thr 
    130                 135                 140                 


Gly Pro Cys Pro Gly Gly Leu Ala Phe His Lys Glu Gly Ala Phe Phe 
145                 150                 155                 160 


Leu Tyr Asp Arg Leu Ala Ser Thr Ile Ile Tyr Arg Gly Thr Thr Phe 
                165                 170                 175     


Ala Glu Gly Val Ile Ala Phe Leu Ile Leu Pro Lys Ala Arg Lys Asp 
            180                 185                 190         


Phe Phe Gln Ser Pro Pro Leu His Glu Pro Ala Asn Met Thr Thr Asp 
        195                 200                 205             


Pro Ser Ser Tyr Tyr His Thr Thr Thr Ile Asn Tyr Val Val Asp Asn 
    210                 215                 220                 


Phe Gly Thr Asn Thr Thr Glu Phe Leu Phe Gln Val Asp His Leu Thr 
225                 230                 235                 240 


Tyr Val Gln Leu Glu Ala Arg Phe Thr Pro Gln Phe Leu Val Leu Leu 
                245                 250                 255     


Asn Glu Thr Ile Tyr Ser Asp Asn Arg Arg Ser Asn Thr Thr Gly Lys 
            260                 265                 270         


Leu Ile Trp Lys Ile Asn Pro Thr Val Asp Thr Ser Met Gly Glu Trp 
        275                 280                 285             


Ala Phe Trp Glu Asn Lys Lys Asn Phe Thr Lys Thr Leu Ser Ser Glu 
    290                 295                 300                 


Glu Leu Ser Phe Val Pro Val Pro Glu Thr Gln Asn Gln Val Leu Asp 
305                 310                 315                 320 


Thr Thr Ala Thr Val Ser Pro Pro Ile Ser Ala His Asn His Ala Gly 
                325                 330                 335     


Glu Asp His Lys Glu Leu Val Ser Glu Asp Ser Thr Pro Val Val Gln 
            340                 345                 350         


Met Gln Asn Ile Lys Gly Lys Asp Thr Met Pro Thr Thr Val Thr Gly 
        355                 360                 365             


Val Pro Thr Thr Thr Pro Ser Pro Phe Pro Ile Asn Ala Arg Asn Thr 
    370                 375                 380                 


Asp His Thr Lys Ser Phe Ile Gly Leu Glu Gly Pro Gln Glu Asp His 
385                 390                 395                 400 


Ser Thr Thr Gln Pro Ala Lys Thr Thr Ser Gln Pro Thr Asn Ser Thr 
                405                 410                 415     


Glu Ser Thr Thr Leu Asn Pro Thr Ser Glu Pro Ser Ser Arg Gly Thr 
            420                 425                 430         


Gly Pro Ser Ser Pro Thr Val Pro Asn Thr Thr Glu Ser His Ala Glu 
        435                 440                 445             


Leu Gly Lys Thr Thr Pro Thr Thr Leu Pro Glu Gln His Thr Ala Ala 
    450                 455                 460                 


Ser Ala Ile Pro Arg Ala Val His Pro Asp Glu Leu Ser Gly Pro Gly 
465                 470                 475                 480 


Phe Leu Thr Asn Thr Ile Arg Gly Val Thr Asn Leu Leu Thr Gly Ser 
                485                 490                 495     


Arg Arg Lys Arg Arg Asp Val Thr Pro Asn Thr Gln Pro Lys Cys Asn 
            500                 505                 510         


Pro Asn Leu His Tyr Trp Thr Ala Leu Asp Glu Gly Ala Ala Ile Gly 
        515                 520                 525             


Leu Ala Trp Ile Pro Tyr Phe Gly Pro Ala Ala Glu Gly Ile Tyr Thr 
    530                 535                 540                 


Glu Gly Ile Met Glu Asn Gln Asn Gly Leu Ile Cys Gly Leu Arg Gln 
545                 550                 555                 560 


Leu Ala Asn Glu Thr Thr Gln Ala Leu Gln Leu Phe Leu Arg Ala Thr 
                565                 570                 575     


Thr Glu Leu Arg Thr Phe Ser Ile Leu Asn Arg Lys Ala Ile Asp Phe 
            580                 585                 590         


Leu Leu Gln Arg Trp Gly Gly Thr Cys His Ile Leu Gly Pro Asp Cys 
        595                 600                 605             


Cys Ile Glu Pro Gln Asp Trp Thr Lys Asn Ile Thr Asp Lys Ile Asp 
    610                 615                 620                 


Gln Ile Ile His Asp Phe Val Asp Asn Asn Leu Pro Asn Gln Asn Asp 
625                 630                 635                 640 


Gly Ser Asn Trp Trp Thr Gly Trp Lys Gln Trp Val Pro Ala Gly Ile 
                645                 650                 655     


Gly Ile Thr Gly Val Ile Ile Ala Ile Ile Ala Leu Leu Cys Ile Cys 
            660                 665                 670         


Lys Phe Met Leu 
        675     


<210>  303
<211>  676
<212>  PRT
<213>  Zaire ebolavirus

<400>  303

Met Gly Val Thr Gly Ile Leu Gln Leu Pro Arg Asp Arg Phe Lys Arg 
1               5                   10                  15      


Thr Ser Phe Phe Leu Trp Val Ile Ile Leu Phe Gln Arg Thr Phe Ser 
            20                  25                  30          


Ile Pro Leu Gly Val Ile His Asn Ser Thr Leu Gln Val Ser Asp Val 
        35                  40                  45              


Asp Lys Leu Val Cys Arg Asp Lys Leu Ser Ser Thr Asn Gln Leu Arg 
    50                  55                  60                  


Ser Val Gly Leu Asn Leu Glu Gly Asn Gly Val Ala Thr Asp Val Pro 
65                  70                  75                  80  


Ser Ala Thr Lys Arg Trp Gly Phe Arg Ser Gly Val Pro Pro Lys Val 
                85                  90                  95      


Val Asn Tyr Glu Ala Gly Glu Trp Ala Glu Asn Cys Tyr Asn Leu Glu 
            100                 105                 110         


Ile Lys Lys Pro Asp Gly Ser Glu Cys Leu Pro Ala Ala Pro Asp Gly 
        115                 120                 125             


Ile Arg Gly Phe Pro Arg Cys Arg Tyr Val His Lys Val Ser Gly Thr 
    130                 135                 140                 


Gly Pro Cys Ala Gly Asp Phe Ala Phe His Lys Glu Gly Ala Phe Phe 
145                 150                 155                 160 


Leu Tyr Asp Arg Leu Ala Ser Thr Val Ile Tyr Arg Gly Thr Thr Phe 
                165                 170                 175     


Ala Glu Gly Val Val Ala Phe Leu Ile Leu Pro Gln Ala Lys Lys Asp 
            180                 185                 190         


Phe Phe Ser Ser His Pro Leu Arg Glu Pro Val Asn Ala Thr Glu Asp 
        195                 200                 205             


Pro Ser Ser Gly Tyr Tyr Ser Thr Thr Ile Arg Tyr Gln Ala Thr Gly 
    210                 215                 220                 


Phe Gly Thr Asn Glu Thr Glu Tyr Leu Phe Glu Val Asp Asn Leu Thr 
225                 230                 235                 240 


Tyr Val Gln Leu Glu Ser Arg Phe Thr Pro Gln Phe Leu Leu Gln Leu 
                245                 250                 255     


Asn Glu Thr Ile Tyr Thr Ser Gly Lys Arg Ser Asn Thr Thr Gly Lys 
            260                 265                 270         


Leu Ile Trp Lys Val Asn Pro Glu Ile Asp Thr Thr Ile Gly Glu Trp 
        275                 280                 285             


Ala Phe Trp Glu Thr Lys Lys Asn Leu Thr Arg Lys Ile Arg Ser Glu 
    290                 295                 300                 


Glu Leu Ser Phe Thr Val Val Ser Asn Gly Ala Lys Asn Ile Ser Gly 
305                 310                 315                 320 


Gln Ser Pro Ala Arg Thr Ser Ser Asp Pro Gly Thr Asn Thr Thr Thr 
                325                 330                 335     


Glu Asp His Lys Ile Met Ala Ser Glu Asn Ser Ser Ala Met Val Gln 
            340                 345                 350         


Val His Ser Gln Gly Arg Glu Ala Ala Val Ser His Leu Thr Thr Leu 
        355                 360                 365             


Ala Thr Ile Ser Thr Ser Pro Gln Ser Leu Thr Thr Lys Pro Gly Pro 
    370                 375                 380                 


Asp Asn Ser Thr His Asn Thr Pro Val Tyr Lys Leu Asp Ile Ser Glu 
385                 390                 395                 400 


Ala Thr Gln Val Glu Gln His His Arg Arg Thr Asp Asn Asp Ser Thr 
                405                 410                 415     


Ala Ser Asp Thr Pro Ser Ala Thr Thr Ala Ala Gly Pro Pro Lys Ala 
            420                 425                 430         


Glu Asn Thr Asn Thr Ser Lys Ser Thr Asp Phe Leu Asp Pro Ala Thr 
        435                 440                 445             


Thr Thr Ser Pro Gln Asn His Ser Glu Thr Ala Gly Asn Asn Asn Thr 
    450                 455                 460                 


His His Gln Asp Thr Gly Glu Glu Ser Ala Ser Ser Gly Lys Leu Gly 
465                 470                 475                 480 


Leu Ile Thr Asn Thr Ile Ala Gly Val Ala Gly Leu Ile Thr Gly Gly 
                485                 490                 495     


Arg Arg Thr Arg Arg Glu Ala Ile Val Asn Ala Gln Pro Lys Cys Asn 
            500                 505                 510         


Pro Asn Leu His Tyr Trp Thr Thr Gln Asp Glu Gly Ala Ala Ile Gly 
        515                 520                 525             


Leu Ala Trp Ile Pro Tyr Phe Gly Pro Ala Ala Glu Gly Ile Tyr Ile 
    530                 535                 540                 


Glu Gly Leu Met His Asn Gln Asp Gly Leu Ile Cys Gly Leu Arg Gln 
545                 550                 555                 560 


Leu Ala Asn Glu Thr Thr Gln Ala Leu Gln Leu Phe Leu Arg Ala Thr 
                565                 570                 575     


Thr Glu Leu Arg Thr Phe Ser Ile Leu Asn Arg Lys Ala Ile Asp Phe 
            580                 585                 590         


Leu Leu Gln Arg Trp Gly Gly Thr Cys His Ile Leu Gly Pro Asp Cys 
        595                 600                 605             


Cys Ile Glu Pro His Asp Trp Thr Lys Asn Ile Thr Asp Lys Ile Asp 
    610                 615                 620                 


Gln Ile Ile His Asp Phe Val Asp Lys Thr Leu Pro Asp Gln Gly Asp 
625                 630                 635                 640 


Asn Asp Asn Trp Trp Thr Gly Trp Arg Gln Trp Ile Pro Ala Gly Ile 
                645                 650                 655     


Gly Val Thr Gly Val Ile Ile Ala Val Ile Ala Leu Phe Cys Ile Cys 
            660                 665                 670         


Lys Phe Val Phe 
        675     


<210>  304
<211>  681
<212>  PRT
<213>  Marburg marburgvirus

<400>  304

Met Lys Thr Thr Cys Phe Leu Ile Ser Leu Ile Leu Ile Gln Gly Thr 
1               5                   10                  15      


Lys Asn Leu Pro Ile Leu Glu Ile Ala Ser Asn Asn Gln Pro Gln Asn 
            20                  25                  30          


Val Asp Ser Val Cys Ser Gly Thr Leu Gln Lys Thr Glu Asp Val His 
        35                  40                  45              


Leu Met Gly Phe Thr Leu Ser Gly Gln Lys Val Ala Asp Ser Pro Leu 
    50                  55                  60                  


Glu Ala Ser Lys Arg Trp Ala Phe Arg Thr Gly Val Pro Pro Lys Asn 
65                  70                  75                  80  


Val Glu Tyr Thr Glu Gly Glu Glu Ala Lys Thr Cys Tyr Asn Ile Ser 
                85                  90                  95      


Val Thr Asp Pro Ser Gly Lys Ser Leu Leu Leu Asp Pro Pro Thr Asn 
            100                 105                 110         


Ile Arg Asp Tyr Pro Lys Cys Lys Thr Ile His His Ile Gln Gly Gln 
        115                 120                 125             


Asn Pro His Ala Gln Gly Ile Ala Leu His Leu Trp Gly Ala Phe Phe 
    130                 135                 140                 


Leu Tyr Asp Arg Ile Ala Ser Thr Thr Met Tyr Arg Gly Lys Val Phe 
145                 150                 155                 160 


Thr Glu Gly Asn Ile Ala Ala Met Ile Val Asn Lys Thr Val His Lys 
                165                 170                 175     


Met Ile Phe Ser Arg Gln Gly Gln Gly Tyr Arg His Met Asn Leu Thr 
            180                 185                 190         


Ser Thr Asn Lys Tyr Trp Thr Ser Ser Asn Gly Thr Gln Thr Asn Asp 
        195                 200                 205             


Thr Gly Cys Phe Gly Ala Leu Gln Glu Tyr Asn Ser Thr Lys Asn Gln 
    210                 215                 220                 


Thr Cys Ala Pro Ser Lys Ile Pro Pro Pro Leu Pro Thr Ala Arg Pro 
225                 230                 235                 240 


Glu Ile Lys Leu Thr Ser Thr Pro Thr Asp Ala Thr Lys Leu Asn Thr 
                245                 250                 255     


Thr Asp Pro Ser Ser Asp Asp Glu Asp Leu Ala Thr Ser Gly Ser Gly 
            260                 265                 270         


Ser Gly Glu Arg Glu Pro His Thr Thr Ser Asp Ala Val Thr Lys Gln 
        275                 280                 285             


Gly Leu Ser Ser Thr Met Pro Pro Thr Pro Ser Pro Gln Pro Ser Thr 
    290                 295                 300                 


Pro Gln Gln Gly Gly Asn Asn Thr Asn His Ser Gln Asp Ala Val Thr 
305                 310                 315                 320 


Glu Leu Asp Lys Asn Asn Thr Thr Ala Gln Pro Ser Met Pro Pro His 
                325                 330                 335     


Asn Thr Thr Thr Ile Ser Thr Asn Asn Thr Ser Lys His Asn Phe Ser 
            340                 345                 350         


Thr Leu Ser Ala Pro Leu Gln Asn Thr Thr Asn Asp Asn Thr Gln Ser 
        355                 360                 365             


Thr Ile Thr Glu Asn Glu Gln Thr Ser Ala Pro Ser Ile Thr Thr Leu 
    370                 375                 380                 


Pro Pro Thr Gly Asn Pro Thr Thr Ala Lys Ser Thr Ser Ser Lys Lys 
385                 390                 395                 400 


Gly Pro Ala Thr Thr Ala Pro Asn Thr Thr Asn Glu His Phe Thr Ser 
                405                 410                 415     


Pro Pro Pro Thr Pro Ser Ser Thr Ala Gln His Leu Val Tyr Phe Arg 
            420                 425                 430         


Arg Lys Arg Ser Ile Leu Trp Arg Glu Gly Asp Met Phe Pro Phe Leu 
        435                 440                 445             


Asp Gly Leu Ile Asn Ala Pro Ile Asp Phe Asp Pro Val Pro Asn Thr 
    450                 455                 460                 


Lys Thr Ile Phe Asp Glu Ser Ser Ser Ser Gly Ala Ser Ala Glu Glu 
465                 470                 475                 480 


Asp Gln His Ala Ser Pro Asn Ile Ser Leu Thr Leu Ser Tyr Phe Pro 
                485                 490                 495     


Asn Ile Asn Glu Asn Thr Ala Tyr Ser Gly Glu Asn Glu Asn Asp Cys 
            500                 505                 510         


Asp Ala Glu Leu Arg Ile Trp Ser Val Gln Glu Asp Asp Leu Ala Ala 
        515                 520                 525             


Gly Leu Ser Trp Ile Pro Phe Phe Gly Pro Gly Ile Glu Gly Leu Tyr 
    530                 535                 540                 


Thr Ala Val Leu Ile Lys Asn Gln Asn Asn Leu Val Cys Arg Leu Arg 
545                 550                 555                 560 


Arg Leu Ala Asn Gln Thr Ala Lys Ser Leu Glu Leu Leu Leu Arg Val 
                565                 570                 575     


Thr Thr Glu Glu Arg Thr Phe Ser Leu Ile Asn Arg His Ala Ile Asp 
            580                 585                 590         


Phe Leu Leu Thr Arg Trp Gly Gly Thr Cys Lys Val Leu Gly Pro Asp 
        595                 600                 605             


Cys Cys Ile Gly Ile Glu Asp Leu Ser Lys Asn Ile Ser Glu Gln Ile 
    610                 615                 620                 


Asp Gln Ile Lys Lys Asp Glu Gln Lys Glu Gly Thr Gly Trp Gly Leu 
625                 630                 635                 640 


Gly Gly Lys Trp Trp Thr Ser Asp Trp Gly Val Leu Thr Asn Leu Gly 
                645                 650                 655     


Ile Leu Leu Leu Leu Ser Ile Ala Val Leu Ile Ala Leu Ser Cys Ile 
            660                 665                 670         


Cys Arg Ile Phe Thr Lys Tyr Ile Gly 
        675                 680     


<210>  305
<211>  426
<212>  PRT
<213>  Xilang striavirus

<400>  305

Met Asn Leu Trp Ile Thr Ile Ala Ala Leu Leu Val Leu Pro Ser His 
1               5                   10                  15      


Leu Pro Ser Thr Val Ser Ala Asp Ile Ile Ala Glu Lys Ser Ile Val 
            20                  25                  30          


Ile Asp Arg Met Ala Lys Leu Ile Ile Pro Leu Gly Pro Pro Ala Thr 
        35                  40                  45              


Ser Ser Lys Cys Ile Asn Ile Lys Glu Ala Glu Arg Gln Asn Gly Asn 
    50                  55                  60                  


Leu Arg Asp Leu Leu Thr Glu His His Lys Pro His Arg Gly Thr Arg 
65                  70                  75                  80  


Ser Ile Thr Leu Ile Leu Thr Leu Leu Ile Met Ile Val Gly Ala Tyr 
                85                  90                  95      


Ile Ala Lys Thr Ala Leu Glu Gly Phe Ser Asn Asn Ala Arg Gln Thr 
            100                 105                 110         


Ala Asp Thr Leu Ser Ser Gln Gly Asp Leu Asn Ala Leu Thr Gly Asn 
        115                 120                 125             


Ala Leu Lys Gln Val Asn Ala Gln Leu Lys Lys Leu Ala Ala Arg Val 
    130                 135                 140                 


Phe Asn Leu Glu Glu Asn Ala Ala Ala Thr Ser Asp Arg Leu Ser Gln 
145                 150                 155                 160 


Leu Glu Cys Ser Gln Lys Phe Leu Met Gly Ala His Thr Asn Pro His 
                165                 170                 175     


Ala Ser Tyr Cys Lys Asn Val Leu Leu Lys His Leu Val Lys Thr Pro 
            180                 185                 190         


Ser Gly Ile Ser Leu Pro Glu Ser Ser Trp Ala Cys Leu Pro Glu Glu 
        195                 200                 205             


Ala Leu Leu Ser Pro Ile Thr Pro Tyr Val Leu Ser Phe Asp Thr Ala 
    210                 215                 220                 


Gly Thr Pro Val Leu Ile Val Gly Tyr Gly Asp Val Ile Ser Ala Gly 
225                 230                 235                 240 


Pro Ile Val Ala Arg Val Phe Asp Phe Thr Val Gly Asn Asp Ser Ser 
                245                 250                 255     


Ala Ser Met Val Val Phe Lys Arg Pro Val Ile Ile Leu Gln Asp Val 
            260                 265                 270         


Tyr Met Ser Pro Glu Ser Cys Gly Cys Thr Ile Met Ala Glu Ser Gln 
        275                 280                 285             


Val Val Cys Arg Ala His Thr Ser Glu Cys Ser Gly Gly Thr Pro Val 
    290                 295                 300                 


Ala Glu Cys Val Gln Arg Gly Asp Cys Met Ala Tyr Glu Ser Leu Glu 
305                 310                 315                 320 


Gly Pro Ala Ile Asn Trp Ala Thr Val Gly Phe Asp Pro Glu Lys Met 
                325                 330                 335     


Thr Met Thr Ala Arg Glu Gly Pro Ile Asn Gly Thr Ser Leu Asp Gln 
            340                 345                 350         


Leu Leu Gln Gln Arg Asp Arg Glu Glu Thr Arg Tyr Gln Thr Asn Met 
        355                 360                 365             


Asp Glu Leu Arg Lys Ser Ser Ile Glu Ala Glu Gly Trp Leu Thr Ala 
    370                 375                 380                 


Leu Lys Arg Tyr Leu Leu Tyr Gly Ala Met Ala Leu Met Ala Leu Phe 
385                 390                 395                 400 


Leu Val Gln Thr Ala Ile Thr Cys Val Lys Asn Leu Gln Ala Glu Asp 
                405                 410                 415     


Asn Arg Ser Arg Ser Thr Arg Gly Gly Tyr 
            420                 425     


<210>  306
<211>  678
<212>  PRT
<213>  San Jacinto virus

<400>  306

Met Tyr Gly Val His Leu Tyr Leu Leu Asn His Met Leu Leu Met Ala 
1               5                   10                  15      


Gln Arg Thr Asn Leu Arg Ser Ser Pro Leu Gln Met Ser Ser Pro Met 
            20                  25                  30          


Ile Cys Pro Lys Asp Gly Gly Leu Thr Ile Asn Arg Leu Ala Glu Pro 
        35                  40                  45              


Leu Asp Cys Gly Ala Asp Thr Thr Ala Ser Pro Val Ala Val Glu Val 
    50                  55                  60                  


Tyr Lys Lys Asn Leu Lys Val Trp Thr Thr Pro Ala Thr Ala Val Tyr 
65                  70                  75                  80  


Lys Glu Glu Trp Ser Cys Thr Ala Thr Cys Tyr Phe Phe Gly Ala Gln 
                85                  90                  95      


Glu His Arg Glu Ile Pro Ala Ala Arg Val Lys Leu Ser Glu Ile Glu 
            100                 105                 110         


Ala Arg Glu Ile Asp His Asn Phe Cys Thr Gly Val Ser Gly Lys Lys 
        115                 120                 125             


Gln Met Gln Gly Asn Lys His Thr Asp Pro His Asp Cys Thr Cys Ser 
    130                 135                 140                 


Trp Thr Gly Thr Trp Lys His Arg Ala Asn Ser Cys Gln Lys Lys Ile 
145                 150                 155                 160 


Gly Glu Val Gln Val Thr His Gly Gly Leu Met Phe Ser Gly Leu Gly 
                165                 170                 175     


Pro Val Ala His Cys Lys Tyr Asp Asp Gly Lys Cys Glu Leu Pro Asp 
            180                 185                 190         


Lys Gln Trp Val Phe Trp Gln Pro Asn Pro Arg Val Gln Glu Asn Tyr 
        195                 200                 205             


Leu Leu Ala Tyr Asn Gly Thr Gly Gln Leu Leu Arg Lys Gly Val Ile 
    210                 215                 220                 


Leu Val Pro Gly Leu Gln Glu Ala Phe Arg Leu Thr Ser Cys Asn Glu 
225                 230                 235                 240 


Lys Ala Thr Val Arg Ser Val Val Ser Cys Asn Thr Ser Thr Gly Phe 
                245                 250                 255     


Ala Leu Ser Tyr Arg Glu Leu Asn Pro Ile Arg Lys Lys Arg Ser Thr 
            260                 265                 270         


Trp Ser Ala Glu Asp Asp Ala Thr Trp Ala Arg Phe Arg Ala Tyr His 
        275                 280                 285             


Glu Ser Glu Gly Asp Gly Met Pro His Val Pro Leu Glu Leu Val Thr 
    290                 295                 300                 


Leu Asn Thr Thr Lys Pro Leu Gly Ala Val Gly Pro Thr Gly Lys Pro 
305                 310                 315                 320 


Leu Asp Glu Thr Val Ala Lys Ala Leu Glu Ala Val Arg Gly Glu Leu 
                325                 330                 335     


Leu Leu Lys Leu Ser Tyr Leu Thr Glu Ala Val Thr Lys Pro Val Met 
            340                 345                 350         


Gln Ile Gly Pro Leu Cys Gln Met Ile Arg Asn His Glu Glu Gln Leu 
        355                 360                 365             


Arg Asn Leu Ala Ile Ala Asn Pro Thr Leu Tyr Val Arg Ala Leu Tyr 
    370                 375                 380                 


Glu Thr Pro Tyr Leu Ile Gly Thr Ser Ala Gly Asp Tyr Ile Gly Val 
385                 390                 395                 400 


Trp Pro Cys Lys Pro Val Leu Asp Tyr Asp Phe Val Glu Gln Thr Gly 
                405                 410                 415     


Asn Cys Thr Lys Asp Pro Pro Ile Lys Tyr Arg Leu Glu Gln Glu Glu 
            420                 425                 430         


Pro Trp Arg Met Gly Tyr Leu Asp Thr Ala Thr Asn Ile Ile Ser Asp 
        435                 440                 445             


Ser Ser Pro Arg Ile Lys Cys Lys Ala Leu Pro Thr Thr Leu Thr Ile 
    450                 455                 460                 


Arg Lys Gln Arg Leu Tyr Leu Tyr Lys Glu Gly Val Met Lys Glu Val 
465                 470                 475                 480 


Pro Lys Ala Gly Ile Thr Glu Phe Ala Gln Ile Lys Pro Arg Ser Ser 
                485                 490                 495     


Asp Ser Phe Leu Ile Asp Trp Gly Asn Asn Trp Leu Tyr Asn Thr Ser 
            500                 505                 510         


Asp Phe Tyr Leu Pro Asn Tyr Glu Ala Asp Val Tyr Asp Tyr Ile Ser 
        515                 520                 525             


Glu Gln Ile Asp Lys Ser Ser Ser Lys Tyr Thr Gly Asp Thr Ala Arg 
    530                 535                 540                 


Ala Asp Glu Gly Asp Arg Ser Thr Ser Val Gly Leu Pro Lys Phe Asn 
545                 550                 555                 560 


Leu Pro Trp Pro Phe Val Thr Leu Gly Leu Phe Gly Ser Leu Leu Lys 
                565                 570                 575     


Tyr Ala Met Tyr Ile Ala Val Gly Trp Leu Leu Leu Asp Arg Phe Arg 
            580                 585                 590         


Gln Gly Arg Arg Gly Ser Ser Ser Ser Asn Gln Thr Thr Lys Ile Glu 
        595                 600                 605             


Phe Gly Thr Leu Arg Glu Thr Pro Ser Pro Pro Pro Pro Thr Glu Asp 
    610                 615                 620                 


Glu Leu Asp Glu Leu Ala Arg Leu His Lys Glu Arg Lys Gln Ala Arg 
625                 630                 635                 640 


Gln Thr Arg Glu Thr Ser Val Glu Arg Gly Leu Lys Arg Leu Asn Asn 
                645                 650                 655     


Leu Phe Gly Lys Arg Lys Ala Glu Arg Glu Asp Pro Glu Glu Ser Ile 
            660                 665                 670         


Pro Met Lys Val Arg Ile 
        675             


<210>  307
<211>  598
<212>  PRT
<213>  Sierra Nevada virus

<400>  307

Met Ile Cys Pro Arg His Gly Gly Met Thr Ile His Arg Leu Pro Glu 
1               5                   10                  15      


Phe Ile Asn Cys Gln Glu Thr Asp Arg His Trp Asn Ala Thr Val Lys 
            20                  25                  30          


Val Tyr Lys Lys Asn Leu Arg Leu Trp Asp Thr Asn Ala Thr Ser Val 
        35                  40                  45              


Phe Lys Glu Glu Trp Lys Cys Ser Ser Thr Cys Tyr Phe Phe Gly Ser 
    50                  55                  60                  


Glu Ala Thr Asn Tyr Glu Ile Thr His Arg Val Arg Ile Gly Glu Pro 
65                  70                  75                  80  


Glu Ala Arg Asp Ile Lys Ala Gly Arg Cys Thr Thr Leu Lys Gly Thr 
                85                  90                  95      


Phe Gly Leu Thr Pro Asp Glu His Ala Glu Lys Lys Asp Cys Ser Cys 
            100                 105                 110         


Ser Trp Thr Gly Thr Asp Glu Ala Ser Ala His Arg Cys Lys Arg Gln 
        115                 120                 125             


Glu Gly Thr Val Gln Val Thr His Gly Gly Ala Met Phe Ser Gly Leu 
    130                 135                 140                 


Gly Pro Val Ser His Cys Asn Tyr Thr Thr Gly Val Cys Glu Leu Pro 
145                 150                 155                 160 


Asp Asn Gln Trp Leu Phe Trp Gln Pro Val Gln Glu Val Gln Glu Glu 
                165                 170                 175     


Phe Ile Leu Ala His Glu Gly Val Gly Phe Val Val Asn Asn Arg Thr 
            180                 185                 190         


Leu Ile Leu Pro Asp Leu Gln Glu Thr Leu Phe Phe Glu Asn Ser Cys 
        195                 200                 205             


Leu Glu Met His Lys Asn Lys Thr Cys Leu Ala Thr Thr Gly Phe Lys 
    210                 215                 220                 


Val Glu Leu Thr Ala Thr Pro Ile Glu Ser Pro Pro Tyr Gln Arg Arg 
225                 230                 235                 240 


Tyr Arg Arg Ser Leu Arg Gly Asp Met Val His Ala Ser Glu Arg Asp 
                245                 250                 255     


Leu His Ala Leu Glu Glu Glu Ile Leu Gly Lys Met Gly Tyr Leu Glu 
            260                 265                 270         


Ser Leu Trp Ala Pro Tyr Ile Asp Glu Val Asp Ser Leu Cys Gln Gln 
        275                 280                 285             


Met Ala Lys His Glu Arg Gln Leu Arg Met Leu Ala Ala Thr Asn Pro 
    290                 295                 300                 


Thr Leu Tyr Leu Arg Ala Val Tyr Ser Asn Pro Phe Leu Ala Gly Ala 
305                 310                 315                 320 


Val Ser Gly Asp Phe Ile Gly Ala Trp Pro Cys Lys Ala Val Met Asp 
                325                 330                 335     


Tyr Asp Phe Leu Glu Gln Ala Ser Pro Asn Cys Thr Arg Asp Pro Pro 
            340                 345                 350         


Val Glu Tyr Arg Leu Glu Arg Glu Gly Pro Trp Lys Pro Gly Tyr Leu 
        355                 360                 365             


Asp Leu Ala Thr Asn Ile Ile Leu Glu Thr Ser Pro Arg Ile Asn Cys 
    370                 375                 380                 


Lys Tyr Leu Pro Thr Thr Ile Thr Gly Arg Asn Gly Arg Leu Phe Leu 
385                 390                 395                 400 


Tyr Lys Gly Gly Arg Met His Glu Gln Asp Thr Ser Leu Ile Arg Thr 
                405                 410                 415     


Leu Pro Gly Ile Lys Lys Glu Ser His Asp Arg Phe Leu Ile Met Trp 
            420                 425                 430         


Asn Asp Thr Trp Leu Tyr Asn Glu Thr Asp Phe Ala Thr Pro Asp Thr 
        435                 440                 445             


Glu Asn Gln Ile Tyr Gln Tyr Ile Glu Glu Lys Ile Asp Gln Thr Ser 
    450                 455                 460                 


Gln Glu Phe Lys Gly Asp Thr Gly Pro Arg Gln Asp Ser Lys Lys Gly 
465                 470                 475                 480 


Gly Phe Leu Pro Leu Thr Arg Leu Gln Pro Trp Phe Ser Leu Glu Ser 
                485                 490                 495     


Phe Trp Arg Ile Arg Asn Ala Cys Thr Leu Leu Trp His Cys Gly Ser 
            500                 505                 510         


Trp Leu Ala Tyr Cys Phe Gln Gly Glu Lys Gln Glu Ser Asn Lys Gln 
        515                 520                 525             


Pro Leu Thr Asp Asp Asn Gln Leu Pro Gly His Asn Gln Gln Glu Ser 
    530                 535                 540                 


Tyr Ile Gly Asp Ser Gln Arg Pro Glu Asn Ser Arg Arg Gly Lys Asn 
545                 550                 555                 560 


Lys Gln Lys Ala Pro Pro Thr Ser Thr Phe Asp Ser Trp Glu Thr Gly 
                565                 570                 575     


Lys Tyr Pro Glu Lys Val Met Ala Leu Ser Ser Leu Arg Asp Arg Thr 
            580                 585                 590         


Cys Arg Asn Gly Ser Leu 
        595             


<210>  308
<211>  567
<212>  PRT
<213>  Soybean cyst nematode nyami-like virus

<400>  308

Met Ser His Lys Thr Ala Ser Leu Met Met Met Trp Leu Ser Phe Thr 
1               5                   10                  15      


Phe Trp Thr Ile Trp Ala Ser Gly Ile Ala Thr Ala Thr Leu Pro Asn 
            20                  25                  30          


Asp Tyr Ala Ala Leu Ile Cys Ala Lys Lys Pro Thr Thr Ile Leu Gln 
        35                  40                  45              


Leu Pro Pro Ser Thr Cys Pro Pro Thr Tyr Thr Glu Ser Arg Gln Val 
    50                  55                  60                  


Lys Gly Val Met Leu Asp Leu Asn Pro Phe Ser His Pro Leu Leu Ala 
65                  70                  75                  80  


Thr Arg Val Cys Lys Val Glu Arg Thr Cys Ser Ile Phe Asp Gln Ser 
                85                  90                  95      


Arg Pro Phe Gly His Ile Tyr Pro Gly Pro Pro Ile Ile Thr Asn Thr 
            100                 105                 110         


Pro Val Pro Leu Ser Glu Tyr Glu Ala Lys Val His Leu Thr Asp Leu 
        115                 120                 125             


Thr Glu His Pro Thr Gly Trp Gln Gln Gln Gly Glu Glu Ala Val Ser 
    130                 135                 140                 


Asn Asp Pro Cys Gln Lys Ile Gln Leu Ser Glu Thr Gly Ile Gly Glu 
145                 150                 155                 160 


Asn Ser Gly Ser Val Val Ser Val Lys Lys Ile Gln Thr Gln Val Arg 
                165                 170                 175     


Gln Glu Gln Thr Arg Thr Gly Arg Val Ile Asn Thr Gly Leu Gly Ser 
            180                 185                 190         


His Cys Asp Tyr Leu Glu Gly Glu Cys Gln Asp Lys His Gly Cys Trp 
        195                 200                 205             


Leu Leu Trp Thr Pro Ala Pro Ser Ala Gln Asn Trp Arg Thr Gly Val 
    210                 215                 220                 


Ala Asp Val Glu Gly Val Leu Tyr Leu Gln Pro Asp Gly Arg Ala Tyr 
225                 230                 235                 240 


Phe His Ser Ala Asn Leu Ser Trp Ser Tyr His Val Arg Glu Thr Gln 
                245                 250                 255     


Arg Asp Gly Thr Pro Ile Trp Met Thr Asp Asp Gly Asp Asn Ala Phe 
            260                 265                 270         


Ile Leu Ile Glu Lys Pro Gly Ala Arg Gly Lys Arg Ala Ile Glu His 
        275                 280                 285             


Thr Gln Leu Ala Leu Asp Leu Gly Asn Ile Ala Asn Ala Arg Leu Asn 
    290                 295                 300                 


Trp Leu Cys Asp Asp Lys Met Gly Ala Ala Leu Trp His Leu Ala Ala 
305                 310                 315                 320 


Trp Gln Ser Ala Pro Thr Ala Val Ala Arg Ser Leu Leu Lys Arg Asp 
                325                 330                 335     


Asp Val His Ala Glu Ala Cys Gly Leu Gly Cys Leu Val Ile Tyr Asp 
            340                 345                 350         


Cys Val Lys Ile Thr Ala Ile Lys Val Ile Glu Thr Thr Glu Cys Tyr 
        355                 360                 365             


Leu His Pro Arg Ile Thr Tyr Arg Leu Pro Ser Glu Thr Arg Glu Ile 
    370                 375                 380                 


Glu Gly His Val Asp Thr Thr Asn Gln Leu Ile Leu Ser Met Ser Pro 
385                 390                 395                 400 


Glu Val Ala Cys Glu Thr Gly Pro Leu Arg Tyr Met Arg Leu Asp Thr 
                405                 410                 415     


Gly Thr Leu Leu Ile Ile Tyr Pro Gly Gly Lys Thr Glu Met Arg Ala 
            420                 425                 430         


Ile Asp Ala Ser Pro Lys Ala Ala Ala Leu Asn Pro Val Leu Met Thr 
        435                 440                 445             


Leu Val Ser Pro Leu Pro Asn Gln Leu Trp Asp Pro Ser Gln Val Asn 
    450                 455                 460                 


Pro Leu Ala Thr Gly Ile Ser Gln Leu Arg Thr Ala Leu Ser Gln Trp 
465                 470                 475                 480 


Thr Gly Ala Asp His Leu Ser Pro Arg Glu Val Glu Glu Ala Met Glu 
                485                 490                 495     


Asn Arg Ala Arg Glu Arg Ala Leu Asn Leu Asn Pro Asp Ala Gly Trp 
            500                 505                 510         


Ile Gly Ala Val Gly Thr Ala Leu Glu Trp Thr Ser Trp Leu Ile Cys 
        515                 520                 525             


Ala Ala Thr Gly Ser Arg Trp Leu Ser Phe Ile Val Thr Met Ser Val 
    530                 535                 540                 


Asp Ala Leu Lys Arg Arg Tyr Leu Thr Gln Pro Arg Pro Glu Ala Pro 
545                 550                 555                 560 


Glu Ser Ala Glu Thr Gly Val 
                565         


<210>  309
<211>  527
<212>  PRT
<213>  Formica fusca virus 1

<400>  309

Met Arg Pro Ser Cys Leu Leu Leu Ala Leu Ala Ala Val Cys Val Thr 
1               5                   10                  15      


Gly Arg Ser Pro Leu Leu Cys Gln Arg Lys Arg Gly Leu Arg Val Phe 
            20                  25                  30          


Lys Lys Asp Glu Pro Leu Asn Cys Leu Ser Asn Ala His Val Gln Thr 
        35                  40                  45              


Val Glu Val Gln Leu Lys Val Pro Ser Phe Lys Glu Ala His Ala Ser 
    50                  55                  60                  


Gly His Trp Thr Gly Leu Tyr Lys Ala Thr Cys Glu Thr His Tyr Phe 
65                  70                  75                  80  


Phe Trp Gly Ser Tyr Thr Arg Glu Phe Trp His Val Ser Val Pro Leu 
                85                  90                  95      


Leu Ser Thr Gln Arg Asn Asp Ile Lys Gln Gly Gly Cys Pro Ser Leu 
            100                 105                 110         


Thr His Pro Val Pro Leu Leu His His Pro Glu Pro Ser Cys Val Tyr 
        115                 120                 125             


Thr Trp Pro Lys Gln Thr Asn Thr Glu Ile Met Tyr Cys Ile Thr Arg 
    130                 135                 140                 


Pro Thr Thr Ile Arg Lys Leu Tyr Gly Gln Pro Leu Thr Ser Asp Glu 
145                 150                 155                 160 


Glu Gln Leu Asp Glu Arg Thr Val Gln Asn Asn Gly Ala Phe Thr Val 
                165                 170                 175     


Thr Gly Ala Val Val His Trp Glu Gln Asn Ile Ile Glu Pro Thr Gln 
            180                 185                 190         


Lys Glu Val Lys Tyr Thr Gly Val Ala Leu Leu Gln Glu Asn Gln Leu 
        195                 200                 205             


Ile Ile Glu Ser Leu Gln Glu Gly Phe Met Leu Leu Pro Gly Pro Thr 
    210                 215                 220                 


Asn Asp Gly Pro Tyr Glu Val Trp Lys Thr Ile Glu Gly Tyr Glu Leu 
225                 230                 235                 240 


Arg Ile Leu Gln Lys Thr Arg Asn Lys Arg Gln Ser Tyr Gln Glu Ala 
                245                 250                 255     


Met Gln Gly Glu Ile Thr Ser Lys Leu Gln Tyr Glu Ser Tyr Ile Met 
            260                 265                 270         


Asp Gln Tyr Leu Gln Lys Phe Gln Gln Thr Cys Phe Lys Gln Gln Leu 
        275                 280                 285             


Thr Thr Arg Thr Leu Asp Thr Ile Tyr Lys Glu Asn Ala Asp Glu Tyr 
    290                 295                 300                 


Ala Arg Ala Leu Leu Asn Glu Thr Asp Ile Thr Ala Ala Thr Ala Gly 
305                 310                 315                 320 


Asp Tyr Leu Leu Val Trp Pro Cys Lys Arg Pro Glu Ile Trp Tyr Ile 
                325                 330                 335     


Arg Glu Gln Glu Asp Glu Gln Val Cys Thr Gln Asp Ile Pro Ile Ile 
            340                 345                 350         


Tyr Thr Ser Asp Ala Lys Asn Tyr Thr Gly Tyr Tyr Lys Ile Arg Thr 
        355                 360                 365             


Gly Arg Ile Val Asn Asp Thr Asn Arg Leu Pro Cys Glu Ser Val Gln 
    370                 375                 380                 


Thr Thr Pro Phe Met Lys Asp Glu Arg Leu Tyr Thr Trp Asp Gly Arg 
385                 390                 395                 400 


Cys Val Thr Arg Ile Ser Thr Glu Gly Val Lys Gly Phe Ala Tyr Pro 
                405                 410                 415     


Asn Gln Gly Ala His Met Ala Pro Val Trp Ser Asn His Trp Leu Tyr 
            420                 425                 430         


His Glu Ser Asp Phe His Arg Glu Pro Pro Leu Tyr Leu Thr Lys Arg 
        435                 440                 445             


Asp Ile Glu Leu Gln Gln Leu Val Gln His Thr Asp Thr Tyr Thr Asn 
    450                 455                 460                 


Thr Val Gly Val Pro Phe Met Asn Met Pro Ser Leu Pro Ser Leu Ala 
465                 470                 475                 480 


Arg Cys Leu Glu Leu Phe Ser Leu Thr Gly Gly Phe Leu Tyr Leu Met 
                485                 490                 495     


Gly Leu Ile Leu Thr Arg Leu Thr Arg Gln Asn Arg Pro Pro Pro Thr 
            500                 505                 510         


Gly Thr Ser Pro Leu Glu Leu Tyr Arg Leu Met Arg Gln Asn Thr 
        515                 520                 525         


<210>  310
<211>  580
<212>  PRT
<213>  Avian metaavulavirus 2

<400>  310

Met Asp Phe Pro Ser Arg Glu Asn Leu Ala Ala Gly Asp Ile Ser Gly 
1               5                   10                  15      


Arg Lys Thr Trp Arg Leu Leu Phe Arg Ile Leu Thr Leu Ser Ile Gly 
            20                  25                  30          


Val Val Cys Leu Ala Ile Asn Ile Ala Thr Ile Ala Lys Leu Asp His 
        35                  40                  45              


Leu Asp Asn Met Ala Ser Asn Thr Trp Thr Thr Thr Glu Ala Asp Arg 
    50                  55                  60                  


Val Ile Ser Ser Ile Thr Thr Pro Leu Lys Val Pro Val Asn Gln Ile 
65                  70                  75                  80  


Asn Asp Met Phe Arg Ile Val Ala Leu Asp Leu Pro Leu Gln Met Thr 
                85                  90                  95      


Ser Leu Gln Lys Glu Ile Thr Ser Gln Val Gly Phe Leu Ala Glu Ser 
            100                 105                 110         


Ile Asn Asn Val Leu Ser Lys Asn Gly Ser Ala Gly Leu Val Leu Val 
        115                 120                 125             


Asn Asp Pro Glu Tyr Ala Gly Gly Ile Ala Val Ser Leu Tyr Gln Gly 
    130                 135                 140                 


Asp Ala Ser Ala Gly Leu Asn Phe Gln Pro Ile Ser Leu Ile Glu His 
145                 150                 155                 160 


Pro Ser Phe Val Pro Gly Pro Thr Thr Ala Lys Gly Cys Ile Arg Ile 
                165                 170                 175     


Pro Thr Phe His Met Gly Pro Ser His Trp Cys Tyr Ser His Asn Ile 
            180                 185                 190         


Ile Ala Ser Gly Cys Gln Asp Ala Ser His Ser Ser Met Tyr Ile Ser 
        195                 200                 205             


Leu Gly Val Leu Lys Ala Ser Gln Thr Gly Ser Pro Ile Phe Leu Thr 
    210                 215                 220                 


Thr Ala Ser Gln Leu Val Asp Asp Asn Ile Asn Arg Lys Ser Cys Ser 
225                 230                 235                 240 


Ile Val Ala Ser Lys Tyr Gly Cys Asp Ile Leu Cys Ser Ile Val Ile 
                245                 250                 255     


Glu Thr Glu Asn Glu Asp Tyr Arg Ser Asp Pro Ala Thr Ser Met Ile 
            260                 265                 270         


Ile Gly Arg Leu Phe Phe Asn Gly Ser Tyr Thr Glu Ser Lys Ile Asn 
        275                 280                 285             


Thr Gly Ser Ile Phe Ser Leu Phe Ser Ala Asn Tyr Pro Ala Val Gly 
    290                 295                 300                 


Ser Gly Ile Val Val Gly Asp Glu Ala Ala Phe Pro Ile Tyr Gly Gly 
305                 310                 315                 320 


Val Lys Gln Asn Thr Trp Leu Phe Asn Gln Leu Lys Asp Phe Gly Tyr 
                325                 330                 335     


Phe Thr His Asn Asp Val Tyr Lys Cys Asn Arg Thr Asp Ile Gln Gln 
            340                 345                 350         


Thr Ile Leu Asp Ala Tyr Arg Pro Pro Lys Ile Ser Gly Arg Leu Trp 
        355                 360                 365             


Val Gln Gly Ile Leu Leu Cys Pro Val Ser Leu Arg Pro Asp Pro Gly 
    370                 375                 380                 


Cys Arg Leu Lys Val Phe Asn Thr Ser Asn Val Met Met Gly Ala Glu 
385                 390                 395                 400 


Ala Arg Leu Ile Gln Val Gly Ser Thr Val Tyr Leu Tyr Gln Arg Ser 
                405                 410                 415     


Ser Ser Trp Trp Val Val Gly Leu Thr Tyr Lys Leu Asp Val Ser Glu 
            420                 425                 430         


Ile Thr Ser Gln Thr Gly Asn Thr Leu Asn His Val Asp Pro Ile Ala 
        435                 440                 445             


His Thr Lys Phe Pro Arg Pro Ser Phe Arg Arg Asp Ala Cys Ala Arg 
    450                 455                 460                 


Pro Asn Ile Cys Pro Ala Val Cys Val Ser Gly Val Tyr Gln Asp Ile 
465                 470                 475                 480 


Trp Pro Ile Ser Thr Ala Thr Asn Asn Ser Asn Ile Val Trp Val Gly 
                485                 490                 495     


Gln Tyr Leu Glu Ala Phe Tyr Ser Arg Lys Asp Pro Arg Ile Gly Ile 
            500                 505                 510         


Ala Thr Gln Tyr Glu Trp Lys Val Thr Asn Gln Leu Phe Asn Ser Asn 
        515                 520                 525             


Thr Glu Gly Gly Tyr Ser Thr Thr Thr Cys Phe Arg Asn Thr Lys Arg 
    530                 535                 540                 


Asp Lys Ala Tyr Cys Val Val Ile Ser Glu Tyr Ala Asp Gly Val Val 
545                 550                 555                 560 


Gly Ser Tyr Arg Ile Val Pro Gln Leu Ile Glu Ile Arg Thr Thr Thr 
                565                 570                 575     


Gly Lys Ser Glu 
            580 


<210>  311
<211>  536
<212>  PRT
<213>  Avian metaavulavirus 2

<400>  311

Met Asn Gln Ala Leu Val Ile Leu Leu Val Ser Phe Gln Leu Gly Val 
1               5                   10                  15      


Ala Leu Asp Asn Ser Val Leu Ala Pro Ile Gly Val Ala Ser Ala Gln 
            20                  25                  30          


Glu Trp Gln Leu Ala Ala Tyr Thr Thr Thr Leu Thr Gly Thr Ile Ala 
        35                  40                  45              


Val Arg Phe Ile Pro Val Leu Pro Gly Asn Leu Ser Thr Cys Ala Gln 
    50                  55                  60                  


Glu Thr Leu Gln Glu Tyr Asn Arg Thr Val Thr Asn Ile Leu Gly Pro 
65                  70                  75                  80  


Leu Arg Glu Asn Leu Asp Ala Leu Leu Ser Asp Phe Asp Lys Pro Ala 
                85                  90                  95      


Ser Arg Phe Val Gly Ala Ile Ile Gly Ser Val Ala Leu Gly Val Ala 
            100                 105                 110         


Thr Ala Ala Gln Ile Thr Ala Ala Val Ala Leu Asn Gln Ala Gln Glu 
        115                 120                 125             


Asn Ala Arg Asn Ile Trp Arg Leu Lys Glu Ser Ile Lys Lys Thr Asn 
    130                 135                 140                 


Glu Ala Val Leu Glu Leu Lys Glu Gly Leu Ala Thr Thr Ala Ile Ala 
145                 150                 155                 160 


Leu Asp Lys Val Gln Lys Phe Ile Asn Asp Asp Ile Ile Pro Gln Ile 
                165                 170                 175     


Lys Asp Ile Asp Cys Gln Val Val Ala Asn Lys Leu Gly Val Tyr Leu 
            180                 185                 190         


Ser Leu Tyr Leu Thr Glu Leu Thr Thr Val Phe Gly Ser Gln Ile Thr 
        195                 200                 205             


Asn Pro Ala Leu Ser Thr Leu Ser Tyr Gln Ala Leu Tyr Ser Leu Cys 
    210                 215                 220                 


Gly Gly Asp Met Gly Lys Leu Thr Glu Leu Ile Gly Val Asn Ala Lys 
225                 230                 235                 240 


Asp Val Gly Ser Leu Tyr Glu Ala Asn Leu Ile Thr Gly Gln Ile Val 
                245                 250                 255     


Gly Tyr Asp Pro Glu Leu Gln Ile Ile Leu Ile Gln Val Ser Tyr Pro 
            260                 265                 270         


Ser Val Ser Glu Val Thr Gly Val Arg Ala Thr Glu Leu Val Thr Val 
        275                 280                 285             


Ser Val Thr Thr Pro Lys Gly Glu Gly Gln Ala Ile Val Pro Arg Tyr 
    290                 295                 300                 


Val Ala Gln Ser Arg Val Leu Thr Glu Glu Leu Asp Val Ser Thr Cys 
305                 310                 315                 320 


Arg Phe Ser Lys Thr Thr Leu Tyr Cys Arg Ser Ile Leu Thr Arg Pro 
                325                 330                 335     


Leu Pro Thr Leu Ile Ala Ser Cys Leu Ser Gly Lys Tyr Asp Asp Cys 
            340                 345                 350         


Gln Tyr Thr Thr Glu Ile Gly Ala Leu Ser Ser Arg Phe Ile Thr Val 
        355                 360                 365             


Asn Gly Gly Val Leu Ala Asn Cys Arg Ala Ile Val Cys Lys Cys Val 
    370                 375                 380                 


Ser Pro Pro His Ile Ile Pro Gln Asn Asp Ile Gly Ser Val Thr Val 
385                 390                 395                 400 


Ile Asp Ser Ser Ile Cys Lys Glu Val Val Leu Glu Ser Val Gln Leu 
                405                 410                 415     


Arg Leu Glu Gly Lys Leu Ser Ser Gln Tyr Phe Ser Asn Val Thr Ile 
            420                 425                 430         


Asp Leu Ser Gln Ile Thr Thr Ser Gly Ser Leu Asp Ile Ser Ser Glu 
        435                 440                 445             


Ile Gly Ser Ile Asn Asn Thr Val Asn Arg Val Asp Glu Leu Ile Lys 
    450                 455                 460                 


Glu Ser Asn Glu Trp Leu Asn Ala Val Asn Pro Arg Leu Val Asn Asn 
465                 470                 475                 480 


Thr Ser Ile Val Val Leu Cys Val Leu Ala Ala Leu Ile Ile Val Trp 
                485                 490                 495     


Leu Ile Ala Leu Thr Val Cys Phe Cys Tyr Ser Ala Arg Tyr Ser Ala 
            500                 505                 510         


Lys Ser Lys Gln Met Arg Gly Ala Met Thr Gly Ile Asp Asn Pro Tyr 
        515                 520                 525             


Val Ile Gln Ser Ala Thr Lys Met 
    530                 535     


<210>  312
<211>  574
<212>  PRT
<213>  Avian metaavulavirus 5

<400>  312

Met Asp Lys Ser Tyr Tyr Thr Glu Pro Glu Asp Gln Arg Gly Asn Ser 
1               5                   10                  15      


Arg Thr Trp Arg Leu Leu Phe Arg Leu Ile Val Leu Thr Leu Leu Cys 
            20                  25                  30          


Leu Ile Ala Cys Thr Ser Val Ser Gln Leu Phe Tyr Pro Trp Leu Pro 
        35                  40                  45              


Gln Val Leu Ser Thr Leu Ile Ser Leu Asn Ser Ser Ile Ile Thr Ser 
    50                  55                  60                  


Ser Asn Gly Leu Lys Lys Glu Ile Leu Asn Gln Asn Ile Lys Glu Asp 
65                  70                  75                  80  


Leu Ile Tyr Arg Glu Val Ala Ile Asn Ile Pro Leu Thr Leu Asp Arg 
                85                  90                  95      


Val Thr Val Glu Val Gly Thr Ala Val Asn Gln Ile Thr Asp Ala Leu 
            100                 105                 110         


Arg Gln Leu Gln Ser Val Asn Gly Ser Ala Ala Phe Ala Leu Ser Asn 
        115                 120                 125             


Ser Pro Asp Tyr Ser Gly Gly Ile Glu His Leu Val Phe Gln Arg Asn 
    130                 135                 140                 


Thr Leu Ile Asn Arg Ser Val Ser Val Ser Asp Leu Ile Glu His Pro 
145                 150                 155                 160 


Ser Phe Ile Pro Thr Pro Thr Thr Gln His Gly Cys Thr Arg Ile Pro 
                165                 170                 175     


Thr Phe His Leu Gly Thr Arg His Trp Cys Tyr Ser His Asn Ile Ile 
            180                 185                 190         


Gly Gln Gly Cys Ala Asp Ser Gly Ala Ser Met Met Tyr Ile Ser Met 
        195                 200                 205             


Gly Ala Leu Gly Val Ser Ser Leu Gly Thr Pro Thr Phe Thr Thr Ser 
    210                 215                 220                 


Ala Thr Ser Ile Leu Ser Asp Ser Leu Asn Arg Lys Ser Cys Ser Ile 
225                 230                 235                 240 


Val Ala Thr Thr Glu Gly Cys Asp Val Leu Cys Ser Ile Val Thr Gln 
                245                 250                 255     


Thr Glu Asp Gln Asp Tyr Ala Asp His Thr Pro Thr Pro Met Ile His 
            260                 265                 270         


Gly Arg Leu Trp Phe Asn Gly Thr Tyr Thr Glu Arg Ser Leu Ser Gln 
        275                 280                 285             


Ser Leu Phe Leu Gly Thr Trp Ala Ala Gln Tyr Pro Ala Val Gly Ser 
    290                 295                 300                 


Gly Ile Met Thr Pro Gly Arg Val Ile Phe Pro Phe Tyr Gly Gly Val 
305                 310                 315                 320 


Ile Pro Asn Ser Pro Leu Phe Leu Asp Leu Glu Arg Phe Ala Leu Phe 
                325                 330                 335     


Thr His Asn Gly Asp Leu Glu Cys Arg Asn Leu Thr Gln Tyr Gln Lys 
            340                 345                 350         


Glu Ala Ile Tyr Ser Ala Tyr Lys Pro Pro Lys Ile Arg Gly Ser Leu 
        355                 360                 365             


Trp Ala Gln Gly Phe Ile Val Cys Ser Val Gly Asp Met Gly Asn Cys 
    370                 375                 380                 


Ser Leu Lys Val Ile Asn Thr Ser Thr Val Met Met Gly Ala Glu Gly 
385                 390                 395                 400 


Arg Leu Gln Leu Val Gly Asp Ser Val Met Tyr Tyr Gln Arg Ser Ser 
                405                 410                 415     


Ser Trp Trp Pro Val Gly Ile Leu Tyr Arg Leu Ser Leu Val Asp Ile 
            420                 425                 430         


Ile Ala Arg Asp Ile Gln Val Val Ile Asn Ser Glu Pro Leu Pro Leu 
        435                 440                 445             


Ser Lys Phe Pro Arg Pro Thr Trp Thr Pro Gly Val Cys Gln Lys Pro 
    450                 455                 460                 


Asn Val Cys Pro Ala Val Cys Val Thr Gly Val Tyr Gln Asp Leu Trp 
465                 470                 475                 480 


Ala Ile Ser Ala Gly Glu Thr Leu Ser Glu Met Thr Phe Phe Gly Gly 
                485                 490                 495     


Tyr Leu Glu Ala Ser Thr Gln Arg Lys Asp Pro Trp Ile Gly Val Ala 
            500                 505                 510         


Asn Gln Tyr Ser Trp Phe Met Arg Arg Arg Leu Phe Lys Thr Ser Thr 
        515                 520                 525             


Glu Ala Ala Tyr Ser Ser Ser Thr Cys Phe Arg Asn Thr Arg Leu Asp 
    530                 535                 540                 


Arg Asn Phe Cys Leu Leu Ile Phe Glu Leu Thr Asp Asn Leu Leu Gly 
545                 550                 555                 560 


Asp Trp Arg Ile Val Pro Leu Leu Phe Glu Leu Thr Ile Val 
                565                 570                 


<210>  313
<211>  544
<212>  PRT
<213>  Avian metaavulavirus 5

<400>  313

Met Leu Gln Leu Pro Leu Thr Ile Leu Leu Ser Ile Leu Ser Ala His 
1               5                   10                  15      


Gln Ser Leu Cys Leu Asp Asn Ser Lys Leu Ile His Ala Gly Ile Met 
            20                  25                  30          


Ser Thr Thr Glu Arg Glu Val Asn Val Tyr Ala Gln Ser Ile Thr Gly 
        35                  40                  45              


Ser Ile Val Val Arg Leu Ile Pro Asn Ile Pro Ser Asn His Lys Ser 
    50                  55                  60                  


Cys Ala Thr Ser Gln Ile Lys Leu Tyr Asn Asp Thr Leu Thr Arg Leu 
65                  70                  75                  80  


Leu Thr Pro Ile Lys Ala Asn Leu Glu Gly Leu Ile Ser Ala Val Ser 
                85                  90                  95      


Gln Asp Gln Ser Gln Asn Ser Gly Lys Arg Lys Lys Arg Phe Val Gly 
            100                 105                 110         


Ala Val Ile Gly Ala Ala Ala Leu Gly Leu Ala Thr Ala Ala Gln Val 
        115                 120                 125             


Thr Ala Thr Val Ala Leu Asn Gln Ala Gln Glu Asn Ala Arg Asn Ile 
    130                 135                 140                 


Leu Arg Leu Lys Asn Ser Ile Gln Lys Thr Asn Glu Ala Val Met Glu 
145                 150                 155                 160 


Leu Lys Asp Ala Val Gly Gln Thr Ala Val Ala Ile Asp Lys Thr Gln 
                165                 170                 175     


Ala Phe Ile Asn Asn Gln Ile Leu Pro Ala Ile Ser Asn Leu Ser Cys 
            180                 185                 190         


Glu Val Leu Gly Asn Lys Ile Gly Val Gln Leu Ser Leu Tyr Leu Thr 
        195                 200                 205             


Glu Leu Thr Thr Val Phe Gly Asn Gln Leu Thr Asn Pro Ala Leu Thr 
    210                 215                 220                 


Thr Leu Ser Leu Gln Ala Leu Tyr Asn Leu Cys Gly Asp Asp Phe Asn 
225                 230                 235                 240 


Tyr Leu Ile Asn Leu Leu Asn Ala Lys Asn Arg Asn Leu Ala Ser Leu 
                245                 250                 255     


Tyr Glu Ala Asn Leu Ile Gln Gly Arg Ile Thr Gln Tyr Asp Ser Met 
            260                 265                 270         


Asn Gln Leu Leu Ile Ile Gln Val Gln Ile Pro Ser Ile Ser Thr Val 
        275                 280                 285             


Ser Gly Met Arg Val Thr Glu Leu Phe Thr Leu Ser Val Asp Thr Pro 
    290                 295                 300                 


Ile Gly Glu Gly Lys Ala Leu Val Pro Lys Tyr Val Leu Ser Ser Gly 
305                 310                 315                 320 


Arg Ile Met Glu Glu Val Asp Leu Ser Ser Cys Ala Ile Thr Ser Thr 
                325                 330                 335     


Ser Val Phe Cys Ser Ser Ile Ile Ser Arg Pro Leu Pro Leu Glu Thr 
            340                 345                 350         


Ile Asn Cys Leu Asn Gly Asn Val Thr Gln Cys Gln Phe Thr Ala Asn 
        355                 360                 365             


Thr Gly Thr Leu Glu Ser Arg Tyr Ala Val Ile Gly Gly Leu Val Ile 
    370                 375                 380                 


Ala Asn Cys Lys Ala Ile Val Cys Arg Cys Leu Asn Pro Pro Gly Val 
385                 390                 395                 400 


Ile Ala Gln Asn Leu Gly Leu Pro Ile Thr Ile Ile Ser Ser Asn Thr 
                405                 410                 415     


Cys Gln Arg Ile Asn Leu Glu Gln Ile Thr Leu Ser Leu Gly Asn Ser 
            420                 425                 430         


Ile Leu Ser Thr Tyr Ser Ala Asn Leu Ser Gln Val Glu Met Asn Leu 
        435                 440                 445             


Ala Pro Ser Asn Pro Leu Asp Ile Ser Val Glu Leu Asn Arg Val Asn 
    450                 455                 460                 


Thr Ser Leu Ser Lys Val Glu Ser Leu Ile Lys Glu Ser Asn Ser Ile 
465                 470                 475                 480 


Leu Asp Ser Val Asn Pro Gln Ile Leu Asn Val Lys Thr Val Ile Ile 
                485                 490                 495     


Leu Ala Val Ile Ile Gly Leu Ile Val Val Trp Cys Phe Ile Leu Thr 
            500                 505                 510         


Cys Leu Ile Val Arg Gly Phe Met Leu Leu Val Lys Gln Gln Lys Phe 
        515                 520                 525             


Lys Gly Leu Ser Val Gln Asn Asn Pro Tyr Val Ser Asn Asn Ser His 
    530                 535                 540                 


<210>  314
<211>  613
<212>  PRT
<213>  Avian metaavulavirus 6

<400>  314

Met Ala Ser Ser Gly Asp Met Arg Gln Ser Gln Ala Thr Leu Tyr Glu 
1               5                   10                  15      


Gly Asp Pro Asn Ser Lys Arg Thr Trp Arg Thr Val Tyr Arg Val Val 
            20                  25                  30          


Thr Ile Leu Leu Asp Ile Thr Val Leu Cys Val Gly Ile Val Ala Ile 
        35                  40                  45              


Val Arg Met Ser Thr Ile Thr Thr Lys Asp Ile Asp Asn Ser Ile Ser 
    50                  55                  60                  


Ser Ser Ile Thr Ser Leu Ser Ala Asp Tyr Gln Pro Ile Trp Ser Asp 
65                  70                  75                  80  


Thr His Gln Lys Val Asn Ser Ile Phe Lys Glu Val Gly Ile Thr Ile 
                85                  90                  95      


Pro Val Thr Leu Asp Lys Met Gln Val Glu Met Gly Thr Ala Val Asn 
            100                 105                 110         


Ile Ile Thr Asp Ala Val Arg Gln Leu Gln Gly Val Asn Gly Ser Ala 
        115                 120                 125             


Gly Phe Ser Ile Thr Asn Ser Pro Glu Tyr Ser Gly Gly Ile Asp Thr 
    130                 135                 140                 


Leu Ile Tyr Pro Leu Asn Ser Leu Asn Gly Lys Ala Leu Ala Val Ser 
145                 150                 155                 160 


Asp Leu Leu Glu His Pro Ser Phe Ile Pro Ala Pro Thr Thr Ser His 
                165                 170                 175     


Gly Cys Ala Arg Ile Pro Thr Phe His Leu Gly Tyr Arg His Trp Cys 
            180                 185                 190         


Tyr Ser His Asn Thr Ile Glu Ser Gly Cys His Asp Ala Gly Glu Ser 
        195                 200                 205             


Ile Met Tyr Val Ser Met Gly Ala Val Gly Val Gly His Arg Gly Arg 
    210                 215                 220                 


Pro Val Phe Thr Thr Ser Ala Ala Thr Ile Leu Asp Asp Gly Arg Asn 
225                 230                 235                 240 


Arg Lys Ser Cys Ser Ile Ile Ala Asn Pro Asn Gly Cys Asp Val Leu 
                245                 250                 255     


Cys Ser Leu Val Lys Gln Thr Glu Asn Glu Asp Tyr Ala Asp Pro Thr 
            260                 265                 270         


Pro Thr Pro Met Ile His Gly Arg Leu His Phe Asn Gly Thr Tyr Thr 
        275                 280                 285             


Glu Ser Glu Leu Asp Pro Gly Leu Phe Asn Asn His Trp Val Ala Gln 
    290                 295                 300                 


Tyr Pro Ala Val Gly Ser Gly Val Val Ser His Arg Lys Leu Phe Phe 
305                 310                 315                 320 


Pro Leu Tyr Gly Gly Ile Ser Pro Lys Ser Lys Leu Phe Asn Glu Leu 
                325                 330                 335     


Lys Ser Phe Ala Tyr Phe Thr His Asn Ala Glu Leu Lys Cys Glu Asn 
            340                 345                 350         


Leu Thr Glu Arg Gln Lys Glu Asp Leu Tyr Asn Ala Tyr Arg Pro Arg 
        355                 360                 365             


Lys Ile Ala Gly Ser Leu Trp Ala Gln Gly Val Val Thr Cys Asn Leu 
    370                 375                 380                 


Thr Asn Leu Ala Asp Cys Lys Val Ala Ile Ala Asn Thr Ser Thr Met 
385                 390                 395                 400 


Met Met Ala Ala Glu Gly Arg Leu Gln Leu Val Gln Asp Lys Ile Val 
                405                 410                 415     


Phe Tyr Gln Arg Ser Ser Ser Trp Trp Pro Val Leu Ile Tyr Tyr Asp 
            420                 425                 430         


Ile Pro Ile Ser Asp Leu Ile Ser Ala Asp His Leu Gly Ile Val Asn 
        435                 440                 445             


Trp Thr Pro Tyr Pro Gln Ser Lys Phe Pro Arg Pro Thr Trp Thr Lys 
    450                 455                 460                 


Gly Val Cys Glu Lys Pro Ala Ile Cys Pro Ala Val Cys Val Thr Gly 
465                 470                 475                 480 


Val Tyr Gln Asp Val Trp Val Val Ser Ile Gly Ser Gln Ser Asn Glu 
                485                 490                 495     


Thr Val Val Val Gly Gly Tyr Leu Asp Ala Ala Ala Ala Arg Gln Asp 
            500                 505                 510         


Pro Trp Ile Ala Ala Ala Asn Gln Tyr Asn Trp Leu Val Arg Arg Arg 
        515                 520                 525             


Leu Phe Thr Ser Gln Thr Glu Ala Ala Tyr Ser Ser Thr Thr Cys Phe 
    530                 535                 540                 


Arg Asn Thr Lys Gln Asp Arg Val Phe Cys Leu Thr Ile Met Glu Val 
545                 550                 555                 560 


Thr Asp Asn Leu Leu Gly Asp Trp Arg Ile Ala Pro Leu Leu Tyr Glu 
                565                 570                 575     


Val Thr Val Ala Asp Lys Gln Gln Gly Asn Arg Asn Tyr Val Pro Met 
            580                 585                 590         


Gly Arg Val Gly Thr Asp Lys Phe Gln Tyr Tyr Thr Pro Gly Asp Arg 
        595                 600                 605             


Tyr Thr Pro Gln His 
    610             


<210>  315
<211>  545
<212>  PRT
<213>  Avian metaavulavirus 6

<400>  315

Met Pro Ser Leu Ser Val Arg Leu Ile Leu Leu Leu Leu Pro His Ile 
1               5                   10                  15      


Ile Leu Thr Leu Asp Asn Ser Arg Leu Leu Gln Gln Gly Ile Met Ser 
            20                  25                  30          


Ala Thr Glu Arg Glu Ile Lys Val Tyr Thr Asn Ser Ile Thr Gly Ser 
        35                  40                  45              


Leu Ala Val Arg Leu Ile Pro Asn Leu Pro Gln Ala Val Gln Ala Cys 
    50                  55                  60                  


Ser Val Gln Gln Ile Lys Ser Tyr Asn Asp Thr Leu Asn Arg Ile Phe 
65                  70                  75                  80  


Thr Pro Ile Arg Val Asn Leu Glu Lys Leu Leu Ser Gly Gln Glu Leu 
                85                  90                  95      


Gln Asp Ser Ser Pro His Ser Ile Arg Glu Pro Arg Leu Val Gly Ala 
            100                 105                 110         


Ile Ile Gly Thr Ala Ala Leu Gly Leu Ala Thr Ala Ala Gln Val Thr 
        115                 120                 125             


Ala Ala Leu Ala Leu Asn Gln Ala Gln Asp Asn Ala Arg Ala Ile Leu 
    130                 135                 140                 


Asn Leu Lys Asp Ser Ile Arg Lys Thr Asn Glu Ala Val Leu Glu Leu 
145                 150                 155                 160 


Lys Glu Ala Thr Gly Gln Ile Ala Val Ala Leu Asp Lys Thr Gln Arg 
                165                 170                 175     


Phe Ile Asn Asp Asn Ile Leu Pro Thr Ile Asn Asn Leu Thr Cys Glu 
            180                 185                 190         


Val Ala Gly Ala Lys Ile Gly Val Glu Leu Ser Leu Tyr Leu Thr Glu 
        195                 200                 205             


Leu Ser Thr Val Phe Gly Ser Gln Ile Thr Asn Pro Ala Leu Ser Thr 
    210                 215                 220                 


Leu Ser Leu Gln Ala Leu Met Ser Leu Cys Gly Asn Asp Phe Asn Tyr 
225                 230                 235                 240 


Leu Leu Asn Leu Met Gly Ala Lys His Ser Asp Leu Gly Ala Leu Tyr 
                245                 250                 255     


Glu Ala Asn Leu Ile Asn Gly Arg Ile Ile Gln Tyr Asp Gln Ala Asn 
            260                 265                 270         


Gln Ile Met Val Ile Gln Val Ser Val Pro Ser Ile Ser Ser Val Ser 
        275                 280                 285             


Gly Leu Arg Leu Thr Glu Leu Phe Thr Leu Ser Ile Glu Thr Pro Ala 
    290                 295                 300                 


Gly Glu Gly Lys Ala Val Val Pro Gln Phe Val Val Glu Ser Gly Gln 
305                 310                 315                 320 


Leu Ile Glu Glu Ile Asp Thr Gln Ala Cys Thr Met Thr Asp Thr Thr 
                325                 330                 335     


Ala Tyr Cys Thr Ile Val Arg Thr Lys Pro Leu Pro Asp Leu Val Val 
            340                 345                 350         


Gly Cys Leu Lys Gly Glu Glu Ser Lys Cys Gln Tyr Thr Thr Gly Ile 
        355                 360                 365             


Gly Met Leu Glu Ser Arg Phe Gly Val Phe Asp Gly Leu Ile Ile Ala 
    370                 375                 380                 


Asn Cys Lys Ala Thr Ile Cys Arg Cys Leu Lys Pro Glu Met Ile Ile 
385                 390                 395                 400 


Pro Gln Asn Arg Gly Ser Pro Ile Thr Val Ile Ser Gln Glu Ile Cys 
                405                 410                 415     


Ser Arg Val Leu Ile Asp Gly Val Thr Leu Gln Val Glu Ala Gln Val 
            420                 425                 430         


Ser Gly Ser Tyr Ser Arg Asn Ile Thr Val Gly Ser Ser Gln Ile Ala 
        435                 440                 445             


Pro Ser Gly Pro Leu Asp Ile Ser Ser Glu Leu Gly Lys Val Asn Gln 
    450                 455                 460                 


Ser Leu Ser Asn Val Glu Asp Leu Ile Asp Gln Ser Asn Gln Ile Leu 
465                 470                 475                 480 


Asn Arg Val Asn Pro Glu Leu Val Asn Asp Thr Ala Ile Ile Val Thr 
                485                 490                 495     


Ile Val Leu Leu Val Leu Leu Val Leu Trp Cys Leu Ala Leu Thr Ile 
            500                 505                 510         


Ser Val Leu Tyr Val Ser Lys His Ala Val Arg Met Val Lys Thr Leu 
        515                 520                 525             


Pro Asn Pro Tyr Val Met Gln Ala Lys Ser Pro Ser Gly Thr Thr Gln 
    530                 535                 540                 


Phe 
545 


<210>  316
<211>  569
<212>  PRT
<213>  Avian metaavulavirus 7

<400>  316

Met Glu Ser Ile Gly Lys Gly Thr Trp Arg Thr Val Tyr Arg Val Leu 
1               5                   10                  15      


Thr Ile Leu Leu Asp Val Val Ile Ile Ile Leu Ser Val Ile Ala Leu 
            20                  25                  30          


Ile Ser Leu Gly Leu Lys Pro Gly Glu Arg Ile Ile Asn Glu Val Asn 
        35                  40                  45              


Gly Ser Ile His Asn Gln Leu Val Pro Leu Ser Gly Ile Thr Ser Asp 
    50                  55                  60                  


Ile Gln Ala Lys Val Ser Ser Ile Tyr Arg Ser Asn Leu Leu Ser Ile 
65                  70                  75                  80  


Pro Leu Gln Leu Asp Gln Ile Asn Gln Ala Ile Ser Ser Ser Ala Arg 
                85                  90                  95      


Gln Ile Ala Asp Thr Ile Asn Ser Phe Leu Ala Leu Asn Gly Ser Gly 
            100                 105                 110         


Thr Phe Ile Tyr Thr Asn Ser Pro Glu Phe Ala Asn Gly Phe Asn Arg 
        115                 120                 125             


Ala Met Phe Pro Thr Leu Asn Gln Ser Leu Asn Met Leu Thr Pro Gly 
    130                 135                 140                 


Asn Leu Ile Glu Phe Thr Asn Phe Ile Pro Thr Pro Thr Thr Lys Ser 
145                 150                 155                 160 


Gly Cys Ile Arg Ile Pro Ser Phe Ser Met Ser Ser Ser His Trp Cys 
                165                 170                 175     


Tyr Thr His Asn Ile Ile Ala Ser Gly Cys Gln Asp His Ser Thr Ser 
            180                 185                 190         


Ser Glu Tyr Ile Ser Met Gly Val Val Glu Val Thr Asp Gln Ala Tyr 
        195                 200                 205             


Pro Asn Phe Arg Thr Thr Leu Ser Ile Thr Leu Ala Asp Asn Leu Asn 
    210                 215                 220                 


Arg Lys Ser Cys Ser Ile Ala Ala Thr Gly Phe Gly Cys Asp Ile Leu 
225                 230                 235                 240 


Cys Ser Val Val Thr Glu Thr Glu Asn Asp Asp Tyr Gln Ser Pro Glu 
                245                 250                 255     


Pro Thr Gln Met Ile Tyr Gly Arg Leu Phe Phe Asn Gly Thr Tyr Ser 
            260                 265                 270         


Glu Met Ser Leu Asn Val Asn Gln Met Phe Ala Asp Trp Val Ala Asn 
        275                 280                 285             


Tyr Pro Ala Val Gly Ser Gly Val Glu Leu Ala Asp Phe Val Ile Phe 
    290                 295                 300                 


Pro Leu Tyr Gly Gly Val Lys Ile Thr Ser Thr Leu Gly Ala Ser Leu 
305                 310                 315                 320 


Ser Gln Tyr Tyr Tyr Ile Pro Lys Val Pro Thr Val Asn Cys Ser Glu 
                325                 330                 335     


Thr Asp Ala Gln Gln Ile Glu Lys Ala Lys Ala Ser Tyr Ser Pro Pro 
            340                 345                 350         


Lys Val Ala Pro Asn Ile Trp Ala Gln Ala Val Val Arg Cys Asn Lys 
        355                 360                 365             


Ser Val Asn Leu Ala Asn Ser Cys Glu Ile Leu Thr Phe Asn Thr Ser 
    370                 375                 380                 


Thr Met Met Met Gly Ala Glu Gly Arg Leu Leu Met Ile Gly Lys Asn 
385                 390                 395                 400 


Val Tyr Phe Tyr Gln Arg Ser Ser Ser Tyr Trp Pro Val Gly Ile Ile 
                405                 410                 415     


Tyr Lys Leu Asp Leu Gln Glu Leu Thr Thr Phe Ser Ser Asn Gln Leu 
            420                 425                 430         


Leu Ser Thr Ile Pro Ile Pro Phe Glu Lys Phe Pro Arg Pro Ala Ser 
        435                 440                 445             


Thr Ala Gly Val Cys Ser Lys Pro Asn Val Cys Pro Ala Val Cys Gln 
    450                 455                 460                 


Thr Gly Val Tyr Gln Asp Leu Trp Val Leu Tyr Asp Leu Gly Lys Leu 
465                 470                 475                 480 


Glu Asn Thr Thr Ala Val Gly Leu Tyr Leu Asn Ser Ala Val Gly Arg 
                485                 490                 495     


Met Asn Pro Phe Ile Gly Ile Ala Asn Thr Leu Ser Trp Tyr Asn Thr 
            500                 505                 510         


Thr Arg Leu Phe Ala Gln Gly Thr Pro Ala Ser Tyr Ser Thr Thr Thr 
        515                 520                 525             


Cys Phe Lys Asn Thr Lys Ile Asp Thr Ala Tyr Cys Leu Ser Ile Leu 
    530                 535                 540                 


Glu Leu Ser Asp Ser Leu Leu Gly Ser Trp Arg Ile Thr Pro Leu Leu 
545                 550                 555                 560 


Tyr Asn Ile Thr Leu Ser Ile Met Ser 
                565                 


<210>  317
<211>  539
<212>  PRT
<213>  Avian metaavulavirus 7

<400>  317

Met Arg Val Arg Pro Leu Ile Ile Ile Leu Val Leu Leu Val Leu Leu 
1               5                   10                  15      


Trp Leu Asn Ile Leu Pro Val Ile Gly Leu Asp Asn Ser Lys Ile Ala 
            20                  25                  30          


Gln Ala Gly Ile Ile Ser Ala Gln Glu Tyr Ala Val Asn Val Tyr Ser 
        35                  40                  45              


Gln Ser Asn Glu Ala Tyr Ile Ala Leu Arg Thr Val Pro Tyr Ile Pro 
    50                  55                  60                  


Pro His Asn Leu Ser Cys Phe Gln Asp Leu Ile Asn Thr Tyr Asn Thr 
65                  70                  75                  80  


Thr Ile Gln Asn Ile Phe Ser Pro Ile Gln Asp Gln Ile Thr Ser Ile 
                85                  90                  95      


Thr Ser Ala Ser Thr Leu Pro Ser Ser Arg Phe Ala Gly Leu Val Val 
            100                 105                 110         


Gly Ala Ile Ala Leu Gly Val Ala Thr Ser Ala Gln Ile Thr Ala Ala 
        115                 120                 125             


Val Ala Leu Thr Lys Ala Gln Gln Asn Ala Gln Glu Ile Ile Arg Leu 
    130                 135                 140                 


Arg Asp Ser Ile Gln Asn Thr Ile Asn Ala Val Asn Asp Ile Thr Val 
145                 150                 155                 160 


Gly Leu Ser Ser Ile Gly Val Ala Leu Ser Lys Val Gln Asn Tyr Leu 
                165                 170                 175     


Asn Asp Val Ile Asn Pro Ala Leu Gln Asn Leu Ser Cys Gln Val Ser 
            180                 185                 190         


Ala Leu Asn Leu Gly Ile Gln Leu Asn Leu Tyr Leu Thr Glu Ile Thr 
        195                 200                 205             


Thr Ile Phe Gly Pro Gln Ile Thr Asn Pro Ser Leu Thr Pro Leu Ser 
    210                 215                 220                 


Ile Gln Ala Leu Tyr Thr Leu Ala Gly Asp Asn Leu Met Gln Phe Leu 
225                 230                 235                 240 


Thr Arg Tyr Gly Tyr Gly Glu Thr Ser Val Ser Ser Ile Leu Glu Ser 
                245                 250                 255     


Gly Leu Ile Ser Ala Gln Ile Val Ser Phe Asp Lys Gln Thr Gly Ile 
            260                 265                 270         


Ala Ile Leu Tyr Val Thr Leu Pro Ser Ile Ala Thr Leu Ser Gly Ser 
        275                 280                 285             


Arg Val Thr Lys Leu Met Ser Val Ser Val Gln Thr Gly Val Gly Glu 
    290                 295                 300                 


Gly Ser Ala Ile Val Pro Ser Tyr Val Ile Gln Gln Gly Thr Val Ile 
305                 310                 315                 320 


Glu Glu Phe Ile Pro Asp Ser Cys Ile Phe Thr Arg Ser Asp Val Tyr 
                325                 330                 335     


Cys Thr Gln Leu Tyr Ser Lys Leu Leu Pro Asp Ser Ile Leu Gln Cys 
            340                 345                 350         


Leu Gln Gly Ser Met Ala Asp Cys Gln Phe Thr Arg Ser Leu Gly Ser 
        355                 360                 365             


Phe Ala Asn Arg Phe Met Thr Val Ala Gly Gly Val Ile Ala Asn Cys 
    370                 375                 380                 


Gln Thr Val Leu Cys Arg Cys Tyr Asn Pro Val Met Ile Ile Pro Gln 
385                 390                 395                 400 


Asn Asn Gly Ile Ala Val Thr Leu Ile Asp Gly Ser Leu Cys Lys Glu 
                405                 410                 415     


Leu Glu Leu Glu Gly Ile Arg Leu Thr Met Ala Asp Pro Val Phe Ala 
            420                 425                 430         


Ser Tyr Ser Arg Asp Leu Ile Ile Asn Gly Asn Gln Phe Ala Pro Ser 
        435                 440                 445             


Asp Ala Leu Asp Ile Ser Ser Glu Leu Gly Gln Leu Asn Asn Ser Ile 
    450                 455                 460                 


Ser Ser Ala Thr Asp Asn Leu Gln Lys Ala Gln Glu Ser Leu Asn Lys 
465                 470                 475                 480 


Ser Ile Ile Pro Ala Ala Thr Ser Ser Trp Leu Ile Ile Leu Leu Phe 
                485                 490                 495     


Val Leu Val Ser Ile Ser Leu Val Ile Gly Cys Ile Ser Ile Tyr Phe 
            500                 505                 510         


Ile Tyr Lys His Ser Thr Thr Asn Arg Ser Arg Asn Leu Ser Ser Asp 
        515                 520                 525             


Ile Ile Ser Asn Pro Tyr Ile Gln Lys Ala Asn 
    530                 535                 


<210>  318
<211>  577
<212>  PRT
<213>  Avian metaavulavirus 8

<400>  318

Met Ser Asn Ile Ala Ser Ser Leu Glu Asn Ile Val Glu Gln Asp Ser 
1               5                   10                  15      


Arg Lys Thr Thr Trp Arg Ala Ile Phe Arg Trp Ser Val Leu Leu Ile 
            20                  25                  30          


Thr Thr Gly Cys Leu Ala Leu Ser Ile Val Ser Ile Val Gln Ile Gly 
        35                  40                  45              


Asn Leu Lys Ile Pro Ser Val Gly Asp Leu Ala Asp Glu Val Val Thr 
    50                  55                  60                  


Pro Leu Lys Thr Thr Leu Ser Asp Thr Leu Arg Asn Pro Ile Asn Gln 
65                  70                  75                  80  


Ile Asn Asp Ile Phe Arg Ile Val Ala Leu Asp Ile Pro Leu Gln Val 
                85                  90                  95      


Thr Ser Ile Gln Lys Asp Leu Ala Ser Gln Phe Ser Met Leu Ile Asp 
            100                 105                 110         


Ser Leu Asn Ala Ile Lys Leu Gly Asn Gly Thr Asn Leu Ile Ile Pro 
        115                 120                 125             


Thr Ser Asp Lys Glu Tyr Ala Gly Gly Ile Gly Asn Pro Val Phe Thr 
    130                 135                 140                 


Val Asp Ala Gly Gly Ser Ile Gly Phe Lys Gln Phe Ser Leu Ile Glu 
145                 150                 155                 160 


His Pro Ser Phe Ile Ala Gly Pro Thr Thr Thr Arg Gly Cys Thr Arg 
                165                 170                 175     


Ile Pro Thr Phe His Met Ser Glu Ser His Trp Cys Tyr Ser His Asn 
            180                 185                 190         


Ile Ile Ala Ala Gly Cys Gln Asp Ala Ser Ala Ser Ser Met Tyr Ile 
        195                 200                 205             


Ser Met Gly Val Leu His Val Ser Ser Ser Gly Thr Pro Ile Phe Leu 
    210                 215                 220                 


Thr Thr Ala Ser Glu Leu Ile Asp Asp Gly Val Asn Arg Lys Ser Cys 
225                 230                 235                 240 


Ser Ile Val Ala Thr Gln Phe Gly Cys Asp Ile Leu Cys Ser Ile Val 
                245                 250                 255     


Ile Glu Lys Glu Gly Asp Asp Tyr Trp Ser Asp Thr Pro Thr Pro Met 
            260                 265                 270         


Arg His Gly Arg Phe Ser Phe Asn Gly Ser Phe Val Glu Thr Glu Leu 
        275                 280                 285             


Pro Val Ser Ser Met Phe Ser Ser Phe Ser Ala Asn Tyr Pro Ala Val 
    290                 295                 300                 


Gly Ser Gly Glu Ile Val Lys Asp Arg Ile Leu Phe Pro Ile Tyr Gly 
305                 310                 315                 320 


Gly Ile Lys Gln Thr Ser Pro Glu Phe Thr Glu Leu Val Lys Tyr Gly 
                325                 330                 335     


Leu Phe Val Ser Thr Pro Thr Thr Val Cys Gln Ser Ser Trp Thr Tyr 
            340                 345                 350         


Asp Gln Val Lys Ala Ala Tyr Arg Pro Asp Tyr Ile Ser Gly Arg Phe 
        355                 360                 365             


Trp Ala Gln Val Ile Leu Ser Cys Ala Leu Asp Ala Val Asp Leu Ser 
    370                 375                 380                 


Ser Cys Ile Val Lys Ile Met Asn Ser Ser Thr Val Met Met Ala Ala 
385                 390                 395                 400 


Glu Gly Arg Ile Ile Lys Ile Gly Ile Asp Tyr Phe Tyr Tyr Gln Arg 
                405                 410                 415     


Ser Ser Ser Trp Trp Pro Leu Ala Phe Val Thr Lys Leu Asp Pro Gln 
            420                 425                 430         


Glu Leu Ala Asp Thr Asn Ser Ile Trp Leu Thr Asn Ser Ile Pro Ile 
        435                 440                 445             


Pro Gln Ser Lys Phe Pro Arg Pro Ser Tyr Ser Glu Asn Tyr Cys Thr 
    450                 455                 460                 


Lys Pro Ala Val Cys Pro Ala Thr Cys Val Thr Gly Val Tyr Ser Asp 
465                 470                 475                 480 


Ile Trp Pro Leu Thr Ser Ser Ser Ser Leu Pro Ser Ile Ile Trp Ile 
                485                 490                 495     


Gly Gln Tyr Leu Asp Ala Pro Val Gly Arg Thr Tyr Pro Arg Phe Gly 
            500                 505                 510         


Ile Ala Asn Gln Ser His Trp Tyr Leu Gln Glu Asp Ile Leu Pro Thr 
        515                 520                 525             


Ser Thr Ala Ser Ala Tyr Ser Thr Thr Thr Cys Phe Lys Asn Thr Ala 
    530                 535                 540                 


Arg Asn Arg Val Phe Cys Val Thr Ile Ala Glu Phe Ala Asp Gly Leu 
545                 550                 555                 560 


Phe Gly Glu Tyr Arg Ile Thr Pro Gln Leu Tyr Glu Leu Val Arg Asn 
                565                 570                 575     


Asn 
    


<210>  319
<211>  543
<212>  PRT
<213>  Avian metaavulavirus 8

<400>  319

Met Gly Lys Ile Ser Ile Tyr Leu Ile Asn Ser Val Leu Leu Leu Leu 
1               5                   10                  15      


Val Tyr Pro Val Asn Ser Ile Asp Asn Thr Leu Val Ala Pro Ile Gly 
            20                  25                  30          


Val Ala Ser Ala Asn Glu Trp Gln Leu Ala Ala Tyr Thr Thr Ser Leu 
        35                  40                  45              


Ser Gly Thr Ile Ala Val Arg Phe Leu Pro Val Leu Pro Asp Asn Met 
    50                  55                  60                  


Thr Thr Cys Leu Arg Glu Thr Ile Thr Thr Tyr Asn Asn Thr Val Asn 
65                  70                  75                  80  


Asn Ile Leu Gly Pro Leu Lys Ser Asn Leu Asp Ala Leu Leu Ser Ser 
                85                  90                  95      


Glu Thr Tyr Pro Gln Thr Arg Leu Ile Gly Ala Val Ile Gly Ser Ile 
            100                 105                 110         


Ala Leu Gly Val Ala Thr Ser Ala Gln Ile Thr Ala Ala Val Ala Leu 
        115                 120                 125             


Lys Gln Ala Gln Asp Asn Ala Arg Asn Ile Leu Ala Leu Lys Glu Ala 
    130                 135                 140                 


Leu Ser Lys Thr Asn Glu Ala Val Lys Glu Leu Ser Ser Gly Leu Gln 
145                 150                 155                 160 


Gln Thr Ala Ile Ala Leu Gly Lys Ile Gln Ser Phe Val Asn Glu Glu 
                165                 170                 175     


Ile Leu Pro Ser Ile Asn Gln Leu Ser Cys Glu Val Thr Ala Asn Lys 
            180                 185                 190         


Leu Gly Val Tyr Leu Ser Leu Tyr Leu Thr Glu Leu Thr Thr Ile Phe 
        195                 200                 205             


Gly Ala Gln Leu Thr Asn Pro Ala Leu Thr Ser Leu Ser Tyr Gln Ala 
    210                 215                 220                 


Leu Tyr Asn Leu Cys Gly Gly Asn Met Ala Met Leu Thr Gln Lys Ile 
225                 230                 235                 240 


Gly Ile Lys Gln Gln Asp Val Asn Ser Leu Tyr Glu Ala Gly Leu Ile 
                245                 250                 255     


Thr Gly Gln Val Ile Gly Tyr Asp Ser Gln Tyr Gln Leu Leu Val Ile 
            260                 265                 270         


Gln Val Asn Tyr Pro Ser Ile Ser Glu Val Thr Gly Val Arg Ala Thr 
        275                 280                 285             


Glu Leu Val Thr Val Ser Val Thr Thr Asp Lys Gly Glu Gly Lys Ala 
    290                 295                 300                 


Ile Val Pro Gln Phe Val Ala Glu Ser Arg Val Thr Ile Glu Glu Leu 
305                 310                 315                 320 


Asp Val Ala Ser Cys Lys Phe Ser Ser Thr Thr Leu Tyr Cys Arg Gln 
                325                 330                 335     


Val Asn Thr Arg Ala Leu Pro Pro Leu Val Ala Ser Cys Leu Arg Gly 
            340                 345                 350         


Asn Tyr Asp Asp Cys Gln Tyr Thr Thr Glu Ile Gly Ala Leu Ser Ser 
        355                 360                 365             


Arg Tyr Ile Thr Leu Asp Gly Gly Val Leu Val Asn Cys Lys Ser Ile 
    370                 375                 380                 


Val Cys Arg Cys Leu Asn Pro Ser Lys Ile Ile Ser Gln Asn Thr Asn 
385                 390                 395                 400 


Ala Ala Val Thr Tyr Val Asp Ala Thr Ile Cys Lys Thr Ile Gln Leu 
                405                 410                 415     


Asp Asp Ile Gln Leu Gln Leu Glu Gly Ser Leu Ser Ser Val Tyr Ala 
            420                 425                 430         


Arg Asn Ile Ser Ile Glu Ile Ser Gln Val Thr Thr Ser Gly Ser Leu 
        435                 440                 445             


Asp Ile Ser Ser Glu Ile Gly Asn Ile Asn Asn Thr Val Asn Arg Val 
    450                 455                 460                 


Glu Asp Leu Ile His Gln Ser Glu Glu Trp Leu Ala Lys Val Asn Pro 
465                 470                 475                 480 


His Ile Val Asn Asn Thr Thr Leu Ile Val Leu Cys Val Leu Ser Ala 
                485                 490                 495     


Leu Ala Val Ile Trp Leu Ala Val Leu Thr Ala Ile Ile Ile Tyr Leu 
            500                 505                 510         


Arg Thr Lys Leu Lys Thr Ile Ser Ala Leu Ala Val Thr Asn Thr Ile 
        515                 520                 525             


Gln Ser Asn Pro Tyr Val Asn Gln Thr Lys Arg Glu Ser Lys Phe 
    530                 535                 540             


<210>  320
<211>  564
<212>  PRT
<213>  Avian metaavulavirus 10

<400>  320

Met Glu Lys Ile Val Leu Leu Leu Ala Ile Val Ser Leu Val Lys Ser 
1               5                   10                  15      


Asp Gln Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Glu Gln Val 
            20                  25                  30          


Asp Thr Ile Met Glu Lys Asn Val Thr Val Thr His Ala Gln Asp Ile 
        35                  40                  45              


Leu Glu Lys Thr His Asn Gly Lys Leu Cys Asp Leu Asp Gly Val Lys 
    50                  55                  60                  


Pro Leu Ile Leu Arg Asp Cys Ser Val Ala Gly Trp Leu Leu Gly Asn 
65                  70                  75                  80  


Pro Met Cys Asp Glu Phe Ile Asn Val Pro Glu Trp Ser Tyr Ile Val 
                85                  90                  95      


Glu Lys Ala Asn Pro Ser Asn Asp Leu Cys Tyr Pro Gly Asn Phe Asn 
            100                 105                 110         


Asp Tyr Glu Glu Leu Lys His Leu Leu Ser Arg Ile Asn His Phe Glu 
        115                 120                 125             


Lys Ile Gln Ile Ile Pro Lys Ser Ser Trp Ser Asp His Glu Ala Ser 
    130                 135                 140                 


Ser Gly Val Ser Ser Ala Cys Pro Tyr Gln Gly Arg Ser Ser Phe Phe 
145                 150                 155                 160 


Arg Asn Val Val Trp Leu Ile Lys Lys Asn Ser Ala Tyr Pro Thr Ile 
                165                 170                 175     


Lys Arg Ser Tyr Asn Asn Thr Asn Gln Glu Asp Leu Leu Val Leu Trp 
            180                 185                 190         


Gly Ile His His Pro Asn Asp Ala Ala Glu Gln Thr Arg Leu Tyr Gln 
        195                 200                 205             


Asn Pro Thr Thr Tyr Ile Ser Val Gly Thr Ser Thr Leu Asn Gln Arg 
    210                 215                 220                 


Leu Val Pro Lys Ile Ala Thr Arg Ser Lys Ile Asn Gly Gln Ser Gly 
225                 230                 235                 240 


Arg Met Glu Phe Phe Trp Thr Ile Leu Lys Pro Asn Asp Ala Ile Ser 
                245                 250                 255     


Phe Glu Ser Asn Gly Asn Phe Ile Ala Pro Glu Tyr Ala Tyr Lys Ile 
            260                 265                 270         


Val Lys Lys Gly Asp Ser Ala Ile Met Lys Ser Glu Leu Glu Tyr Gly 
        275                 280                 285             


Asn Cys Asn Thr Lys Cys Gln Thr Pro Met Gly Ala Ile Asn Ser Ser 
    290                 295                 300                 


Met Pro Phe His Asn Ile His Pro Leu Thr Ile Gly Glu Cys Pro Lys 
305                 310                 315                 320 


Tyr Val Lys Ser Ser Arg Leu Val Leu Ala Thr Gly Leu Arg Asn Ser 
                325                 330                 335     


Pro Gln Arg Glu Thr Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile 
            340                 345                 350         


Glu Gly Gly Trp Gln Gly Met Val Asp Gly Trp Tyr Gly Tyr His His 
        355                 360                 365             


Ser Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Lys Glu Ser Thr Gln 
    370                 375                 380                 


Lys Ala Ile Asp Gly Val Thr Asn Lys Val Asn Ser Ile Ile Asp Lys 
385                 390                 395                 400 


Met Asn Thr Gln Phe Glu Ala Val Gly Arg Glu Phe Asn Asn Leu Glu 
                405                 410                 415     


Arg Arg Ile Glu Asn Leu Asn Lys Lys Met Glu Asp Gly Phe Leu Asp 
            420                 425                 430         


Val Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Met Glu Asn Glu Arg 
        435                 440                 445             


Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Asp Lys Val 
    450                 455                 460                 


Arg Leu Gln Leu Arg Asp Asn Ala Lys Glu Leu Gly Asn Gly Cys Phe 
465                 470                 475                 480 


Glu Phe Tyr His Arg Cys Asp Asn Glu Cys Ile Glu Ser Val Arg Asn 
                485                 490                 495     


Gly Thr Tyr Asp Tyr Pro Gln Tyr Ser Glu Glu Ala Arg Leu Lys Arg 
            500                 505                 510         


Glu Glu Ile Ser Gly Val Lys Leu Glu Ser Ile Gly Thr Tyr Gln Ile 
        515                 520                 525             


Leu Ser Ile Tyr Ser Thr Val Ala Ser Ser Leu Ala Leu Ala Ile Met 
    530                 535                 540                 


Val Ala Gly Leu Ser Leu Trp Met Cys Ser Asn Gly Ser Leu Gln Cys 
545                 550                 555                 560 


Arg Ile Cys Ile 
                


<210>  321
<211>  536
<212>  PRT
<213>  Avian metaavulavirus 10

<400>  321

Met Thr Arg Thr Arg Leu Leu Phe Leu Leu Thr Cys Tyr Ile Pro Gly 
1               5                   10                  15      


Ala Val Ser Leu Asp Asn Ser Ile Leu Ala Pro Ala Gly Ile Ile Ser 
            20                  25                  30          


Ala Ser Glu Arg Gln Ile Ala Ile Tyr Thr Gln Thr Leu Gln Gly Thr 
        35                  40                  45              


Ile Ala Leu Arg Phe Ile Pro Val Leu Pro Gln Asn Leu Ser Ser Cys 
    50                  55                  60                  


Ala Lys Asp Thr Leu Glu Ser Tyr Asn Ser Thr Val Ser Asn Leu Leu 
65                  70                  75                  80  


Leu Pro Ile Ala Glu Asn Leu Asn Ala Leu Leu Lys Asp Ala Asp Lys 
                85                  90                  95      


Pro Ser Gln Arg Ile Ile Gly Ala Ile Ile Gly Ser Val Ala Leu Gly 
            100                 105                 110         


Val Ala Thr Thr Ala Gln Val Thr Ala Ala Leu Ala Met Thr Gln Ala 
        115                 120                 125             


Gln Gln Asn Ala Arg Asn Ile Trp Lys Leu Lys Glu Ser Ile Lys Asn 
    130                 135                 140                 


Thr Asn Gln Ala Val Leu Glu Leu Lys Asp Gly Leu Gln Gln Ser Ala 
145                 150                 155                 160 


Ile Ala Leu Asp Lys Val Gln Ser Phe Ile Asn Ser Glu Ile Leu Pro 
                165                 170                 175     


Gln Ile Asn Gln Leu Gly Cys Glu Val Ala Ala Asn Lys Leu Gly Ile 
            180                 185                 190         


Phe Leu Ser Leu Tyr Leu Thr Glu Ile Thr Thr Val Phe Lys Asn Gln 
        195                 200                 205             


Ile Thr Asn Pro Ala Leu Ser Thr Leu Ser Tyr Gln Ala Leu Tyr Asn 
    210                 215                 220                 


Leu Cys Gly Gly Asn Met Ala Ala Leu Thr Lys Gln Ile Gly Ile Lys 
225                 230                 235                 240 


Asp Thr Glu Ile Asn Ser Leu Tyr Glu Ala Glu Leu Ile Thr Gly Gln 
                245                 250                 255     


Val Ile Gly Tyr Asp Ser Ala Asp Gln Ile Leu Leu Ile Gln Val Ser 
            260                 265                 270         


Tyr Pro Ser Val Ser Arg Val Gln Gly Val Arg Ala Val Glu Leu Leu 
        275                 280                 285             


Thr Val Ser Val Ala Thr Pro Lys Gly Glu Gly Lys Ala Ile Ala Pro 
    290                 295                 300                 


Ser Phe Ile Ala Gln Ser Asn Ile Ile Ala Glu Glu Leu Asp Thr Gln 
305                 310                 315                 320 


Pro Cys Lys Phe Ser Lys Thr Thr Leu Tyr Cys Arg Gln Val Asn Thr 
                325                 330                 335     


Arg Thr Leu Pro Val Arg Val Ala Asn Cys Leu Lys Gly Lys Tyr Asn 
            340                 345                 350         


Asp Cys Gln Tyr Thr Thr Glu Ile Gly Ala Leu Ala Ser Arg Tyr Val 
        355                 360                 365             


Thr Ile Thr Asn Gly Val Val Ala Asn Cys Arg Ser Ile Ile Cys Arg 
    370                 375                 380                 


Cys Leu Asp Pro Glu Gly Ile Val Ala Gln Asn Ser Asp Ala Ala Ile 
385                 390                 395                 400 


Thr Val Ile Asp Arg Ser Thr Cys Lys Leu Ile Gln Leu Gly Asp Ile 
                405                 410                 415     


Thr Leu Arg Leu Glu Gly Lys Leu Ser Ser Ser Tyr Ser Lys Asn Ile 
            420                 425                 430         


Thr Ile Asp Ile Ser Gln Val Thr Thr Ser Gly Ser Leu Asp Ile Ser 
        435                 440                 445             


Ser Glu Leu Gly Ser Ile Asn Asn Thr Ile Thr Lys Val Glu Asp Leu 
    450                 455                 460                 


Ile Ser Lys Ser Asn Asp Trp Leu Ser Lys Val Asn Pro Thr Leu Ile 
465                 470                 475                 480 


Ser Asn Asp Thr Ile Ile Ala Leu Cys Val Ile Ala Gly Ile Val Val 
                485                 490                 495     


Ile Trp Leu Val Ile Ile Thr Ile Leu Ser Tyr Tyr Ile Leu Ile Lys 
            500                 505                 510         


Leu Lys Asn Val Ala Leu Leu Ser Thr Met Pro Lys Lys Asp Leu Asn 
        515                 520                 525             


Pro Tyr Val Asn Asn Thr Lys Phe 
    530                 535     


<210>  322
<211>  583
<212>  PRT
<213>  Avian metaavulavirus 11

<400>  322

Met Asp Arg Ser Arg Ser Leu Asp Tyr Leu Ala Asp Ser Pro Glu Ile 
1               5                   10                  15      


Lys Asn Thr Trp Arg Gln Phe Phe Arg Val Val Leu Ile Ile Leu Gln 
            20                  25                  30          


Ile Thr Met Leu Cys Ile Ser Ile Ser Ala Leu Ala Ile Thr Ile Gln 
        35                  40                  45              


Val Arg Asp Gln His Leu Pro Ser Leu Ile Lys Glu Asn Pro Lys Thr 
    50                  55                  60                  


Thr Ser Ser Leu Ile Ser Ser Glu Leu Asn Pro Leu Leu Ser Tyr Leu 
65                  70                  75                  80  


Pro Gly Ile Asn Arg Glu Val Gln Leu Asn Ile Pro Ile Gln Leu Asp 
                85                  90                  95      


Lys Ile Gln Gln Ser Ala Thr Ser Glu Ile Asn Arg Leu Thr Ala Ala 
            100                 105                 110         


Ile Asn Gln Met Ala Phe Gly Thr Leu Ser Pro Gly Leu Leu Leu Lys 
        115                 120                 125             


Asn Ser Lys Asp Tyr Val Gly Gly Ile Asn Lys Pro Leu Ile Pro Ser 
    130                 135                 140                 


Asp Lys Leu Asn Trp Thr Asn Ala Thr Ile Ser Gly Phe Ile Glu His 
145                 150                 155                 160 


Pro Ser Phe Ile Pro Gly Pro Thr Thr Lys Lys Gly Cys Thr Arg Ile 
                165                 170                 175     


Pro Ser Phe His Leu Ala Glu Ser His Trp Cys Tyr Thr His Asn Thr 
            180                 185                 190         


Ile Ala Ser Gly Cys Glu Asp His Gly Val Ser Ser Met Tyr Ile Ser 
        195                 200                 205             


Gly Gly Ile Leu Tyr Lys Gly Ser Asn Lys Glu Pro Ser Leu Leu Thr 
    210                 215                 220                 


Thr Val Ser Ile Leu Leu Ala Asp Glu Leu Asn Arg Lys Ser Cys Ser 
225                 230                 235                 240 


Ile Ile Ala Ser Ser Tyr Gly Cys Asp Val Leu Cys Ser Leu Val Thr 
                245                 250                 255     


Glu Ser Glu Ser Gln Asp Tyr Lys Ser Val Asn Pro Thr Pro Met Val 
            260                 265                 270         


His Gly Arg Leu Phe Phe Asn Gly Ser Tyr Ser Glu Gln Glu Leu Asp 
        275                 280                 285             


Pro Arg Ile Phe Gly Asp Leu Trp Thr Ala Asn Tyr Pro Gly Val Gly 
    290                 295                 300                 


Ser Gly Ile Leu Leu Lys Asp Arg Leu Val Phe Pro Ile Tyr Gly Gly 
305                 310                 315                 320 


Leu Asp Glu Thr Lys Leu Asn Leu Thr Ser Tyr Leu Asn His Pro Leu 
                325                 330                 335     


Tyr Thr Lys Asn Glu Trp Val Ser Cys Asn Lys Ser Tyr Asp Glu Val 
            340                 345                 350         


Val Gln Thr Leu Arg Ala Ala Tyr Arg Pro Ser Trp Phe Ala Gly Arg 
        355                 360                 365             


Val Val Thr Gln Gly Val Met Val Cys His Tyr Asp Arg Glu Leu Leu 
    370                 375                 380                 


Gly Arg Cys Leu Ile Ala Arg Phe Asn Thr Ser Thr Val Met Met Gly 
385                 390                 395                 400 


Ala Glu Ser Arg Leu Val Met Gln Gly Asp Ser Leu Leu Leu Tyr Gln 
                405                 410                 415     


Arg Ser Ser Ser Trp Trp Pro Val Gly Ile Val Tyr Leu Val Pro Glu 
            420                 425                 430         


Ser Ile Ile Ser Ile Asn Glu Thr Asn Ser Val Phe Asp Leu Ser Pro 
        435                 440                 445             


Ile Pro Leu Ser Lys Phe Pro Arg Pro Thr Asn Lys Lys Gly Tyr Cys 
    450                 455                 460                 


Glu Arg Pro Ala Val Cys Pro Ala Val Cys Val Thr Gly Val Tyr Gln 
465                 470                 475                 480 


Asp Leu Trp Pro Leu Ser Pro Leu Ala Ile Glu Asn Arg Thr Ala Thr 
                485                 490                 495     


Asn Pro Thr Phe Ala Gly Ala Phe Leu Asn Ala Phe Thr Thr Arg Thr 
            500                 505                 510         


Ala Pro Tyr Phe Gly Val Ala Gly Pro Asn Lys Trp Ala Arg Ser Val 
        515                 520                 525             


Gln Leu Phe Thr Asp Gln Thr Pro Ala Ser Tyr Ser Thr Thr Thr Cys 
    530                 535                 540                 


Phe Lys Asp Thr Ile Thr Thr Gln Thr Tyr Cys Leu Ile Ile Ile Glu 
545                 550                 555                 560 


Leu Gln Glu Asn Leu Leu Gly Thr Trp Lys Ile Val Pro Leu Leu Val 
                565                 570                 575     


Lys Val Ser Leu Val Tyr Ser 
            580             


<210>  323
<211>  562
<212>  PRT
<213>  Avian metaavulavirus 11

<400>  323

Met Gly Thr Cys Leu Asn Asn Arg Leu Ser Thr Ile Pro Ser Ile Lys 
1               5                   10                  15      


Thr Val Gln Cys Ile Leu Ile Ile Leu Ser Tyr Ile Ile Pro Tyr Ser 
            20                  25                  30          


Ala Thr Asp Asn Pro Ile Ala Asp Arg Ser Leu Leu Arg Ala Gly Ile 
        35                  40                  45              


Val Pro Ile Tyr Ser Lys Ser Leu Ser Val Tyr Thr Asn Ser Ile Ser 
    50                  55                  60                  


Gly Tyr Leu Thr Val Arg Met Leu Pro Pro Leu Pro Lys Asn Leu Thr 
65                  70                  75                  80  


Glu Cys Ser Gln Glu Val Val Ser Asn Tyr Asn Lys Thr Ile Thr Arg 
                85                  90                  95      


Met Phe Gln Pro Ile Ser Asp Asn Leu Met Arg Ile Gln Glu Gly Thr 
            100                 105                 110         


Asp Ser Gly Thr Lys Arg Phe Val Gly Ala Val Ile Gly Ser Val Ala 
        115                 120                 125             


Leu Gly Val Ala Thr Ser Ala Gln Ile Thr Ala Ala Leu Ala Met Val 
    130                 135                 140                 


Gln Ala Gln Asp Asn Ala Lys Ala Ile Trp Lys Leu Lys Glu Ala Ile 
145                 150                 155                 160 


Ser Ser Thr Asn Gln Ala Val Leu Glu Leu Lys Glu Gly Val Asn Thr 
                165                 170                 175     


Leu Gly Val Ala Val Asp Lys Ile Gln Gly Tyr Ile Asn Asn Glu Ile 
            180                 185                 190         


Leu Pro Ser Leu Ser Glu Leu Glu Cys Arg Val Asn Ala Asn Lys Leu 
        195                 200                 205             


Ala Ser Gln Leu Asn Leu Tyr Leu Ile Glu Leu Thr Thr Ile Phe Gly 
    210                 215                 220                 


Asp Gln Ile Thr Asn Pro Ala Leu Thr Pro Leu Ser Leu Gln Ala Leu 
225                 230                 235                 240 


Tyr Thr Leu Ala Gly Asp Thr Met Gly Ser Phe Leu Gln Tyr Ile Gly 
                245                 250                 255     


Ala Gln Asp Asn Glu Ile Glu Ser Leu Tyr Asp Ser Gly Leu Ile Asn 
            260                 265                 270         


Gly Gln Ile Val Ser Tyr Asp Ala Ser Ile Gln Thr Ile Ile Ile Lys 
        275                 280                 285             


Val Ser Ile Pro Ser Ile Ser Ser Leu Ser Arg Phe Ser Ile Met Arg 
    290                 295                 300                 


Leu Ala Thr Val Ser Ser Ser Val Gly Gly Phe Glu Lys Thr Pro Leu 
305                 310                 315                 320 


Val Pro Glu Tyr Leu Leu Ile Ser Asp Asn His Ile Glu Glu Phe Ser 
                325                 330                 335     


Ile Val Asp Cys Lys Glu Ser Ser Asp Ile Phe Tyr Cys Pro Gln Ile 
            340                 345                 350         


Leu Ser Met Pro Ile Ser Thr Ala Thr Val Glu Cys Leu Lys Gly Arg 
        355                 360                 365             


Ile Asp Gln Cys Ile Tyr Thr Ser Gln Leu Thr Ile Leu Ser His Arg 
    370                 375                 380                 


Ile Val Thr Tyr Asn Gly Val Val Val Ala Asn Cys Phe Ala Glu Leu 
385                 390                 395                 400 


Cys Arg Cys Thr Asn Pro Ser Tyr Ile Ile Arg Gln Asp Arg Asp Val 
                405                 410                 415     


Ala Val Thr Val Ile Asp Lys Asp Leu Cys Lys Arg Val Gln Ile Gly 
            420                 425                 430         


Asp Ile Glu Leu Ile Val Gln Ala Ser Ile Ala Asn Glu Tyr Lys Val 
        435                 440                 445             


Asn Phe Thr Val Ser Glu Asp Gln Leu Ala Pro Ser Thr Pro Ile Asp 
    450                 455                 460                 


Ile Ser Asn Glu Leu Asn Ser Leu Asn Gln Thr Leu Asp Lys Val Gly 
465                 470                 475                 480 


Gln Leu Ile Asn Thr Ser Asn Gln Ile Leu Ala Ser Leu Asn Pro Lys 
                485                 490                 495     


Leu Val Asn Asn Thr Ser Ile Ile Val Leu Ile Val Met Gly Val Val 
            500                 505                 510         


Leu Ile Leu Trp Leu Leu Ala Leu Thr Ile Tyr Ser Ile Tyr Ala Ala 
        515                 520                 525             


Arg Asn Leu Asn Ser Ile Gly Arg Leu Ala Lys Ser Ala Tyr Ala Ser 
    530                 535                 540                 


Tyr Val Ala Asp Lys Asn Val Tyr Lys Asn Glu Ser Thr Ser Ser Ser 
545                 550                 555                 560 


Ser Ile 
        


<210>  324
<211>  580
<212>  PRT
<213>  Avian metaavulavirus 14

<400>  324

Met Glu Gly Ser Arg Thr Val Ile Tyr Gln Gly Asp Pro Asn Glu Lys 
1               5                   10                  15      


Asn Thr Trp Arg Leu Val Phe Arg Thr Leu Thr Leu Ile Leu Asn Leu 
            20                  25                  30          


Ala Ile Leu Ser Val Thr Ile Ala Ser Ile Ile Ile Thr Ser Lys Ile 
        35                  40                  45              


Thr Leu Ser Glu Val Thr Thr Leu Lys Thr Glu Gly Val Glu Glu Val 
    50                  55                  60                  


Ile Thr Pro Leu Met Ala Thr Leu Ser Asp Ser Val Gln Gln Glu Lys 
65                  70                  75                  80  


Met Ile Tyr Lys Glu Val Ala Ile Ser Ile Pro Leu Val Leu Asp Lys 
                85                  90                  95      


Ile Gln Thr Asp Val Gly Thr Ser Val Ala Gln Ile Thr Asp Ala Leu 
            100                 105                 110         


Arg Gln Ile Gln Gly Val Asn Gly Thr Gln Ala Phe Ala Leu Ser Asn 
        115                 120                 125             


Ala Pro Glu Tyr Ser Gly Gly Ile Glu Val Pro Leu Phe Gln Ile Asp 
    130                 135                 140                 


Ser Phe Val Asn Lys Ser Met Ser Ile Ser Gly Leu Leu Glu His Ala 
145                 150                 155                 160 


Ser Phe Ile Pro Ser Pro Thr Thr Leu His Gly Cys Thr Arg Ile Pro 
                165                 170                 175     


Ser Phe His Leu Gly Pro Arg His Trp Cys Tyr Thr His Asn Ile Ile 
            180                 185                 190         


Gly Ser Arg Cys Arg Asp Glu Gly Phe Ser Ser Met Tyr Ile Ser Ile 
        195                 200                 205             


Gly Ala Ile Thr Val Asn Arg Asp Gly Asn Pro Leu Phe Ile Thr Thr 
    210                 215                 220                 


Ala Ser Thr Ile Leu Ala Asp Asp Asn Asn Arg Lys Ser Cys Ser Ile 
225                 230                 235                 240 


Ile Ala Ser Ser Tyr Gly Cys Asp Leu Leu Cys Ser Ile Val Thr Glu 
                245                 250                 255     


Ser Glu Asn Asp Asp Tyr Ala Asn Pro Asn Pro Thr Lys Met Val His 
            260                 265                 270         


Gly Arg Phe Leu Tyr Asn Gly Ser Tyr Val Glu Gln Ala Leu Pro Asn 
        275                 280                 285             


Ser Leu Phe Gln Asp Lys Trp Val Ala Gln Tyr Pro Gly Val Gly Ser 
    290                 295                 300                 


Gly Ile Thr Thr His Gly Lys Val Leu Phe Pro Ile Tyr Gly Gly Ile 
305                 310                 315                 320 


Lys Lys Asn Thr Gln Leu Phe Tyr Glu Leu Ser Lys Tyr Gly Phe Phe 
                325                 330                 335     


Ala His Asn Lys Glu Leu Glu Cys Lys Asn Met Thr Glu Glu Gln Ile 
            340                 345                 350         


Arg Asp Ile Lys Ala Ala Tyr Leu Pro Ser Lys Thr Ser Gly Asn Leu 
        355                 360                 365             


Phe Ala Gln Gly Ile Ile Tyr Cys Asn Ile Ser Lys Leu Gly Asp Cys 
    370                 375                 380                 


Asn Val Ala Val Leu Asn Thr Ser Thr Thr Met Met Gly Ala Glu Gly 
385                 390                 395                 400 


Arg Leu Gln Met Met Gly Glu Tyr Val Tyr Tyr Tyr Gln Arg Ser Ser 
                405                 410                 415     


Ser Trp Trp Pro Val Gly Ile Val Tyr Lys Lys Ser Leu Ala Glu Leu 
            420                 425                 430         


Met Asn Gly Ile Asn Met Glu Val Leu Ser Phe Glu Pro Ile Pro Leu 
        435                 440                 445             


Ser Lys Phe Pro Arg Pro Thr Trp Thr Ala Gly Leu Cys Gln Lys Pro 
    450                 455                 460                 


Ser Ile Cys Pro Asp Val Cys Val Thr Gly Val Tyr Thr Asp Leu Phe 
465                 470                 475                 480 


Ser Val Thr Ile Gly Ser Thr Thr Asp Lys Asp Thr Tyr Phe Gly Val 
                485                 490                 495     


Tyr Leu Asp Ser Ala Thr Glu Arg Lys Asp Pro Trp Val Ala Ala Ala 
            500                 505                 510         


Asp Gln Tyr Glu Trp Arg Asn Arg Val Arg Leu Phe Glu Ser Thr Thr 
        515                 520                 525             


Glu Ala Ala Tyr Thr Thr Ser Thr Cys Phe Lys Asn Thr Val Asn Asn 
    530                 535                 540                 


Arg Val Phe Cys Val Ser Ile Val Glu Leu Arg Glu Asn Leu Leu Gly 
545                 550                 555                 560 


Asp Trp Lys Ile Val Pro Leu Leu Phe Gln Ile Gly Val Ser Gln Gly 
                565                 570                 575     


Pro Pro Pro Lys 
            580 


<210>  325
<211>  541
<212>  PRT
<213>  Avian metaavulavirus 14

<400>  325

Met Glu Lys Gly Thr Val Leu Phe Leu Ala Ala Leu Thr Leu Tyr Asn 
1               5                   10                  15      


Val Lys Ala Leu Asp Asn Thr Lys Leu Leu Gly Ala Gly Ile Ala Ser 
            20                  25                  30          


Gly Lys Glu His Glu Leu Lys Ile Tyr Gln Ser Ser Val Asn Gly Tyr 
        35                  40                  45              


Ile Ala Val Lys Leu Ile Pro Phe Leu Pro Ser Thr Lys Arg Glu Cys 
    50                  55                  60                  


Tyr Asn Glu Gln Leu Lys Asn Tyr Asn Ala Thr Ile Asn Arg Leu Met 
65                  70                  75                  80  


Gly Pro Ile Asn Asp Asn Ile Lys Leu Val Leu Ser Gly Val Lys Thr 
                85                  90                  95      


Arg Thr Arg Glu Gly Lys Leu Ile Gly Ala Ile Ile Gly Thr Ala Ala 
            100                 105                 110         


Leu Gly Leu Ala Thr Ala Ala Gln Val Thr Ala Ala Ile Ala Leu Glu 
        115                 120                 125             


Gln Ala Gln Asp Asn Ala Arg Ala Ile Leu Thr Leu Lys Glu Ser Ile 
    130                 135                 140                 


Arg Asn Thr Asn Asn Ala Val Ser Glu Leu Lys Thr Gly Leu Ser Glu 
145                 150                 155                 160 


Val Ser Ile Ala Leu Ser Lys Thr Gln Asp Tyr Ile Asn Thr Gln Ile 
                165                 170                 175     


Met Pro Ala Leu Ser Asn Leu Ser Cys Glu Ile Val Gly Leu Lys Ile 
            180                 185                 190         


Gly Ile Gln Leu Ser Gln Tyr Leu Thr Glu Val Thr Ala Val Phe Gly 
        195                 200                 205             


Asn Gln Ile Thr Asn Pro Ala Leu Gln Pro Leu Ser Met Gln Ala Leu 
    210                 215                 220                 


Tyr Gln Leu Cys Gly Gly Asp Phe Ser Leu Leu Leu Asp Lys Ile Gly 
225                 230                 235                 240 


Ala Asp Arg Asn Glu Leu Glu Ser Leu Tyr Glu Ala Asn Leu Val Thr 
                245                 250                 255     


Gly Arg Ile Val Gln Tyr Asp Thr Ala Asp Gln Leu Val Ile Ile Gln 
            260                 265                 270         


Val Ser Ile Pro Ser Val Ser Thr Leu Ser Gly Tyr Arg Val Thr Glu 
        275                 280                 285             


Leu Gln Ser Ile Ser Val Asp Met Asp His Gly Glu Gly Lys Ala Val 
    290                 295                 300                 


Ile Pro Arg Tyr Ile Val Thr Ser Gly Arg Val Ile Glu Glu Met Asp 
305                 310                 315                 320 


Ile Ser Pro Cys Val Leu Thr Ala Thr Ala Val Tyr Cys Asn Arg Leu 
                325                 330                 335     


Leu Thr Thr Ser Leu Pro Glu Ser Val Leu Lys Cys Leu Asp Gly Asp 
            340                 345                 350         


His Ser Ser Cys Thr Tyr Thr Ser Asn Ser Gly Val Leu Glu Thr Arg 
        355                 360                 365             


Tyr Ile Ala Phe Asp Gly Met Leu Ile Ala Asn Cys Arg Ser Ile Val 
    370                 375                 380                 


Cys Lys Cys Leu Asp Pro Pro Tyr Ile Ile Pro Gln Asn Lys Gly Lys 
385                 390                 395                 400 


Pro Leu Thr Ile Ile Ser Lys Glu Val Cys Lys Lys Val Thr Leu Asp 
                405                 410                 415     


Gly Ile Thr Leu Leu Ile Asp Ala Glu Phe Thr Gly Glu Tyr Gly Leu 
            420                 425                 430         


Asn Ile Thr Ile Gly Pro Asp Gln Phe Ala Pro Ser Gly Ala Leu Asp 
        435                 440                 445             


Ile Ser Thr Glu Leu Gly Lys Leu Asn Asn Ser Ile Asn Lys Ala Glu 
    450                 455                 460                 


Asp Tyr Ile Asp Lys Ser Asn Glu Leu Leu Asn Arg Val Asn Val Asp 
465                 470                 475                 480 


Ile Val Asn Asp Thr Ala Val Ile Val Leu Cys Val Met Ser Ala Leu 
                485                 490                 495     


Val Val Val Trp Cys Ile Gly Leu Thr Val Gly Leu Ile Tyr Val Ser 
            500                 505                 510         


Lys Asn Thr Leu Arg Ala Val Ala Ile Lys Gly Thr Ser Ile Glu Asn 
        515                 520                 525             


Pro Tyr Val Ser Ser Gly Lys His Ala Lys Asn Ser Ser 
    530                 535                 540     


<210>  326
<211>  579
<212>  PRT
<213>  Avian metaavulavirus 15

<400>  326

Met Asn Ser Ser Tyr Ser Gln Asp Asn Leu Tyr Thr Asn Gln Thr Ala 
1               5                   10                  15      


Ala Gln Pro Arg Gly Thr Trp Arg Val Leu Tyr Arg Ala Val Ser Leu 
            20                  25                  30          


Ile Phe Gln Ile Leu Ile Phe Ser Leu Val Leu Thr Asn Val Ile Gln 
        35                  40                  45              


Tyr Ser Asn Leu His Ser Pro Ser Val Ser Glu Ile Ser Ala Ala Thr 
    50                  55                  60                  


Thr Thr Glu Thr Ile Asp Gly Leu Lys Pro His Leu Glu Thr Pro Leu 
65                  70                  75                  80  


Asn Gln Ile Asn Asp Ile Phe Arg Leu Thr Ala Leu Asp Leu Pro Ile 
                85                  90                  95      


Gln Met Asn Thr Met Thr Arg Glu Ile Thr Ser Gln Leu Asn Ile Leu 
            100                 105                 110         


Thr Ser Gly Ile Asn Glu Leu Val Thr Ser Asn Asn Ser Gly Arg Leu 
        115                 120                 125             


Leu Gln Thr Thr Asp Pro Ala Tyr Thr Gly Gly Ile Gly Val Phe Val 
    130                 135                 140                 


Leu Asn Asn Tyr Leu Asp Tyr Pro Pro Asn Leu Gln Asn Met Ser Leu 
145                 150                 155                 160 


Leu Glu Gln Pro Asn Phe Val Pro Gly Ser Thr Thr Thr Gly Gly Cys 
                165                 170                 175     


Thr Arg Ile Pro Thr Phe His Leu Ser Ser Thr His Trp Cys Tyr Ser 
            180                 185                 190         


His Asn Ile Ile Glu Lys Gly Cys His Asp Ala Gly His Ser Ser Met 
        195                 200                 205             


Tyr Ile Ser Ile Gly Val Val Gln Val Ser Ser Arg Gly Val Pro Val 
    210                 215                 220                 


Phe Leu Thr Thr Gln Ser Val Ile Val Asp Asp Glu Thr Asn Arg Lys 
225                 230                 235                 240 


Ser Cys Ser Ile Val Ser Thr Glu Tyr Gly Cys Asp Ile Leu Cys Ser 
                245                 250                 255     


Ile Val Thr Glu Arg Glu Ser Asp Asp Tyr Lys Ser Asp Pro Pro Thr 
            260                 265                 270         


Arg Met Leu His Gly Arg Leu Leu Phe Asn Gly Ser Tyr Val Glu Ala 
        275                 280                 285             


Ala Val Lys Phe Thr Asn Asp Ile Asn Lys Phe Ser Ala Asn Tyr Pro 
    290                 295                 300                 


Gly Val Gly Ser Gly Ile Leu Leu Gly Asn Lys Ile Leu Phe Pro Leu 
305                 310                 315                 320 


Tyr Gly Gly Ile Lys Gln Ser Thr Asp Leu Phe Asn Tyr Leu His Asn 
                325                 330                 335     


Arg Thr Ala Gln Val Ser Asn Asn Lys Thr Val Cys Ser Thr Gly Tyr 
            340                 345                 350         


Asp Lys Lys Lys Leu Glu Ala Ala Tyr Arg Pro Pro Leu Ile Gly Gly 
        355                 360                 365             


Arg Phe Trp Ala Ile Gly Ile Val Ile Cys Lys Phe Ser Ile Asn Ser 
    370                 375                 380                 


Leu Gly Asp Cys Arg Tyr Lys Ile Tyr Asp Ser Ser Val Val Met Met 
385                 390                 395                 400 


Gly Ser Glu Asn Arg Leu Met Lys Val Gly Asn Gln Val Phe Leu Tyr 
                405                 410                 415     


Gln Arg Ser Ser Ser Trp Trp Pro Ile Gly Leu Thr Tyr Ile Leu Asn 
            420                 425                 430         


Ser Thr Asp Leu Leu Asn Thr Asp Ser Asp Ile Val Ser Ser Ile Ile 
        435                 440                 445             


Pro Ile Tyr His Thr Lys Phe Pro Arg Pro Thr Tyr Asp Arg Asn Ala 
    450                 455                 460                 


Cys Thr Arg Pro Asn Val Cys Pro Ala Thr Cys Ile Glu Gly Val Tyr 
465                 470                 475                 480 


Ala Asp Ile Trp Pro Leu Asn Asn Pro Ala Glu Pro Ser Lys Ile Ile 
                485                 490                 495     


Trp Val Ser His Tyr Leu Asn Ser Glu Val Gly Arg Glu Phe Pro Ala 
            500                 505                 510         


Ile Gly Val Ala Asn Gln Tyr Glu Trp Val Lys Glu Phe Arg Pro Leu 
        515                 520                 525             


Pro Pro Thr Thr Gly Ala Ala Tyr Ala Thr Thr Ser Cys Phe Lys Asn 
    530                 535                 540                 


Thr Ile Ser Asn Arg Ile Phe Cys Val Ser Val Ala Glu Phe Lys Asp 
545                 550                 555                 560 


Asn Leu Phe Gly Gln Phe Arg Ile Val Pro Leu Leu Tyr Glu Ile Lys 
                565                 570                 575     


Val Ile Asn 
            


<210>  327
<211>  542
<212>  PRT
<213>  Avian metaavulavirus 15

<400>  327

Met Tyr Val Pro Gly Val Ile Leu Ala Leu Leu Met Ile Asn Pro Cys 
1               5                   10                  15      


Leu Thr Leu Asp Asn Ser Lys Leu Ala Pro Val Gly Ile Ile Ser Ala 
            20                  25                  30          


Ala Glu His Glu Leu Ala Ile Tyr Thr Asn Thr Leu Ser Gly Ser Ile 
        35                  40                  45              


Ala Val Arg Phe Leu Pro Asn Leu Pro Ala Asn Leu Thr His Cys Gln 
    50                  55                  60                  


Lys Thr Ile Leu Asp Asn Tyr Asn Val Thr Val Thr Arg Ile Leu Lys 
65                  70                  75                  80  


Pro Ile Ala Asp Asn Leu Asn Ile Leu Lys His Gly Leu Glu Val Pro 
                85                  90                  95      


Lys Glu Arg Leu Val Gly Ala Ile Ile Gly Thr Val Ala Leu Gly Val 
            100                 105                 110         


Ala Thr Ser Ala Gln Ile Thr Ala Ala Val Ala Val Ala Gln Ala Gln 
        115                 120                 125             


Gln Asn Ala Lys Asp Ile Trp Lys Leu Lys Asn Ala Ile Leu Ser Thr 
    130                 135                 140                 


Asn Glu Ala Val Leu Glu Leu Lys Thr Gly Leu Gln Gln Thr Ala Ile 
145                 150                 155                 160 


Ala Leu Asp Lys Ile Gln Asp Tyr Ile Asn Asn Glu Ile Ile Pro Thr 
                165                 170                 175     


Val Asn Asn Leu Thr Cys Glu Val Met Ala Asn Arg Leu Gly Val Tyr 
            180                 185                 190         


Leu Ser Leu Tyr Leu Thr Glu Leu Thr Thr Val Phe Gly Asn Gln Ile 
        195                 200                 205             


Thr Asn Pro Ala Leu Ser Thr Ile Ser Tyr Gln Gly Leu Thr Asn Leu 
    210                 215                 220                 


Cys Gly Asn Asn Ile Gly Ala Leu Thr Lys Leu Ile Gly Leu Lys Asp 
225                 230                 235                 240 


Asp Asn Val Glu Ser Ile Tyr Glu Ala Gly Leu Ile Thr Gly Gln Val 
                245                 250                 255     


Val Asp Tyr Asp Pro Ala Ser Gln Ile Leu Ile Ile Gln Val Ser Tyr 
            260                 265                 270         


Pro Ser Ile Ser Arg Leu Ser Asp Ile Arg Ala Thr Glu Leu Ile Thr 
        275                 280                 285             


Val Gly Val Thr Thr Pro Phe Gly Glu Gly Arg Ala Ile Val Pro Lys 
    290                 295                 300                 


Tyr Val Ala Gln Ser Thr Val Leu Ile Glu Glu Leu Asp Ile Ser Ser 
305                 310                 315                 320 


Cys Lys Phe Ser Ser Thr Thr Leu Tyr Cys Thr Gln Ile Asn Thr Arg 
                325                 330                 335     


Pro Leu Pro Pro Arg Val Ser Ser Cys Leu Lys Gly Asp Tyr Glu Asn 
            340                 345                 350         


Cys Gln Phe Thr Thr Glu Val Gly Val Leu Ala Ser Arg Tyr Ala Ser 
        355                 360                 365             


Ile Gly Lys Gly Val Val Val Asn Cys Arg Ser Ile Ile Cys Lys Cys 
    370                 375                 380                 


Leu Glu Pro Pro Arg Ile Ile Pro Gln Asn Ser Leu Ala Ser Ile Thr 
385                 390                 395                 400 


Val Ile Asp Ser Lys Ile Cys Lys Lys Leu Gln Leu Pro Asp Val Ile 
                405                 410                 415     


Leu Arg Leu Asp Gly Asn Leu Glu Ser Gln Tyr Phe Thr Asn Ile Ser 
            420                 425                 430         


Ile Asn Gly Gly Gln Val Thr Pro Ser Gly Pro Leu Asp Ile Ser Ser 
        435                 440                 445             


Glu Ile Gly Asn Ile Asn Gln Thr Val Asn Arg Val Glu Asp Leu Ile 
    450                 455                 460                 


His Glu Ser Glu Ser Trp Leu Ser Arg Val Asn Pro Lys Leu Ile Ser 
465                 470                 475                 480 


Asn Thr Ala Ile Ile Val Leu Cys Val Leu Ser Ser Leu Cys Val Leu 
                485                 490                 495     


Trp Leu Ile Leu Ile Thr Ala Phe Met Ala Lys Leu Leu Ser Asn Val 
            500                 505                 510         


Lys Lys Ile Glu Arg Lys Val Ala Val Ser Ser Leu Ile Gly Asn Pro 
        515                 520                 525             


Tyr Val Tyr Thr Asn Pro Gly Tyr Ser Gly Ser Lys Ser Ala 
    530                 535                 540         


<210>  328
<211>  537
<212>  PRT
<213>  Avian metaavulavirus 20

<400>  328

Met Met Asp Ser Leu Arg Leu Thr Ile Leu Leu Val Ala Trp Phe Ser 
1               5                   10                  15      


Leu Gly Glu Cys Leu Asp Asn Ala Asn Thr Gly Pro Ile Gly Val Leu 
            20                  25                  30          


Lys Ser Lys Glu Trp Gln Leu Ala Ala Tyr Thr Gln Ser Leu Tyr Gly 
        35                  40                  45              


Thr Ile Ala Val Arg Phe Ile Pro Ile Leu Pro Ser Asn Leu Thr Ser 
    50                  55                  60                  


Cys Met Leu Ser Val Ile Gln Asp Tyr Asn Gln Thr Val Ser Ser Leu 
65                  70                  75                  80  


Leu Gly Pro Ile Gly Asn Asn Leu Asp Ser Ile Ile Ser Ser Ser Gly 
                85                  90                  95      


Glu Gln Gln Ala Arg Leu Ile Gly Ala Ile Val Gly Thr Val Ala Leu 
            100                 105                 110         


Gly Val Ala Thr Ser Ala Gln Ile Thr Ala Ala Leu Ala Val Asn Gln 
        115                 120                 125             


Ala Gln Asp Asn Ala Arg Gln Ile Trp Lys Leu Lys Glu Ala Ile Leu 
    130                 135                 140                 


Lys Thr Asn Asp Ala Val Leu Glu Leu Lys Glu Gly Leu Ser Gln Thr 
145                 150                 155                 160 


Ala Val Ala Leu Asp Lys Val Gln Ser Phe Ile Asn Asn Glu Ile Leu 
                165                 170                 175     


Pro Gln Ile Ser Ser Ile Ser Cys Glu Val Ala Ala Asn Lys Leu Gly 
            180                 185                 190         


Val Phe Leu Ser Leu Tyr Leu Thr Glu Leu Thr Thr Val Phe Gly Asn 
        195                 200                 205             


Gln Ile Thr Asn Pro Ala Leu Thr Pro Leu Ser Tyr Gln Ala Leu Tyr 
    210                 215                 220                 


Asn Leu Cys Gly Gly Asn Leu Ala Ala Leu Thr Arg Gln Met Gly Ile 
225                 230                 235                 240 


Lys Asp Asp Thr Leu Thr Ser Leu Tyr Glu Ala Gly Leu Ile Val Gly 
                245                 250                 255     


Gln Ile Ile Gly Tyr Asp Ala Ser Ser Gln Ile Leu Leu Ile Gln Val 
            260                 265                 270         


Ser Tyr Pro Ser Val Ser Glu Ile Thr Gly Val Arg Ala Thr Glu Leu 
        275                 280                 285             


Val Thr Val Ser Val Ala Thr Ile Lys Gly Glu Gly Arg Ala Ile Val 
    290                 295                 300                 


Pro Gln Phe Val Ala Glu Gly His Val Thr Ile Glu Glu Leu Asp Thr 
305                 310                 315                 320 


Ser Pro Cys Arg Phe Ser Lys Ser Thr Leu Phe Cys Arg Ser Ile Leu 
                325                 330                 335     


Thr Arg Pro Leu Pro Ile Arg Val Ala Asn Cys Leu Ser Gly Lys Tyr 
            340                 345                 350         


Asp Asp Cys Gln Tyr Thr Thr Glu Ile Gly Leu Leu Ser Ser Arg Tyr 
        355                 360                 365             


Val Thr Val Asp Gly Gly Val Met Ala Asn Cys Lys Ser Thr Val Cys 
    370                 375                 380                 


Lys Cys Leu Asn Pro Glu Lys Ile Ile Leu Gln Lys Thr Ala Ser Ala 
385                 390                 395                 400 


Ile Thr Ala Ile Asp Lys Asn Thr Cys Lys Leu Leu Gln Ile Asn Asp 
                405                 410                 415     


Val Lys Leu Arg Leu Glu Gly Thr Leu His Ser Gln Tyr Phe Arg Asn 
            420                 425                 430         


Ile Ser Ile Ala Ser Asn Gln Ile Thr Ser Ser Gly Ser Leu Asp Ile 
        435                 440                 445             


Ser Ser Glu Ile Gly Ala Ile Asn Asn Thr Val Asn Lys Val Glu Asp 
    450                 455                 460                 


Leu Ile Asn Gln Ser Asn Gly Trp Leu Asp Ser Val Asn Pro Lys Leu 
465                 470                 475                 480 


Met Ser Asn Thr Thr Ile Ile Ile Leu Cys Val Leu Ser Gly Leu Ala 
                485                 490                 495     


Ile Val Trp Leu Leu Ile Leu Thr Ile Ile Met Cys Tyr Ser Ala Tyr 
            500                 505                 510         


Lys Leu Lys Ser Leu Ser Ile Ile Ala Ala Met Asn Ser Ala Thr Lys 
        515                 520                 525             


Asn Pro Tyr Val Ser Asn Thr Lys Phe 
    530                 535         


<210>  329
<211>  574
<212>  PRT
<213>  Avian metaavulavirus 20

<400>  329

Met Ser Thr Ala Asp Ile Leu Ser His Ile Glu Asn Tyr Gly Gln Lys 
1               5                   10                  15      


Asn Thr Trp Arg Ser Ala Phe Arg Ile Thr Ser Leu Ile Leu Leu Leu 
            20                  25                  30          


Leu Ile Thr Gly Met Thr Ile Ala Gly Leu Val Ile Ala Ser Asn Gln 
        35                  40                  45              


Ser Cys Ala Thr Ser Glu Glu Leu Ala Asp Pro Ile Thr Glu Lys Leu 
    50                  55                  60                  


Ile Thr Ser Ile Arg Asp Leu Leu Thr Val Ser Asn Asn Gln Ile Asn 
65                  70                  75                  80  


Asp Ile Phe Lys Ile Val Ala Leu Asp Ile Pro Leu Gln Val Ser Ser 
                85                  90                  95      


Ile Gln Gln Asp Ile Ser Ser Gln Phe Asn Lys Leu Met Glu Gly Ile 
            100                 105                 110         


Thr Ser Leu Ile Gly Tyr Asn Asn Ser Ala Gly Val Ile Ser Thr Ile 
        115                 120                 125             


Asp Pro Ser Tyr Ser Gly Gly Ile Gly Val Pro Leu Phe Thr Thr Ser 
    130                 135                 140                 


Gly Asn Ser Thr Leu Gln Ile His Pro Val Ser Leu Ile Glu His Pro 
145                 150                 155                 160 


Ser Phe Ile Pro Asn Pro Thr Thr Asn Arg Gly Cys Thr Arg Ile Pro 
                165                 170                 175     


Thr Phe His Leu Ser Arg Thr His Trp Cys Tyr Ser His Asn Val Ile 
            180                 185                 190         


Ala Lys Gly Cys Ala Asp Phe Gly Lys Ser Gly Met Tyr Ile Ser Leu 
        195                 200                 205             


Gly Val Ile Lys Thr Ala Glu Leu Gly Thr Pro Val Phe Leu Thr Thr 
    210                 215                 220                 


Ala Ser Gln Tyr Val Asp Asp Gly Val Asn Arg Lys Ser Cys Ser Ile 
225                 230                 235                 240 


Ala Ala Thr Arg Phe Gly Cys Asp Ile Leu Cys Ser Ile Val Thr Glu 
                245                 250                 255     


Lys Glu Asn Asp Asp Tyr Ala Ser Asp Pro Pro Thr Glu Met Val His 
            260                 265                 270         


Gly Arg Leu Phe Phe Asn Gly Thr Phe Ser Asp Ser Asn Leu Asp Val 
        275                 280                 285             


Lys Asn Leu Phe Arg Asp Phe Ser Ala Asn Tyr Pro Ser Val Gly Ser 
    290                 295                 300                 


Gly Glu Val Ile Gly Asp Ile Val Met Phe Pro Phe Tyr Gly Gly Val 
305                 310                 315                 320 


Arg Gln Arg Thr Ser Leu Phe Asp Gln Leu Ser Gln Phe Gly Leu Phe 
                325                 330                 335     


Val His Asn Asn Arg Tyr Thr Cys Glu Gln Asn Trp Thr Met Thr Thr 
            340                 345                 350         


Val Lys Gln Ser Tyr Leu Pro Pro Lys Ile Ser Gly Arg Phe Trp Ala 
        355                 360                 365             


Gln Gly Ile Val Lys Cys Arg Leu Val Leu Gln Thr Leu Ala Asn Cys 
    370                 375                 380                 


Ser Ile Ser Val Phe Asn Ser Ser Lys Val Met Met Gly Ala Glu Ala 
385                 390                 395                 400 


Arg Leu Met Leu Val Gly Thr Thr Leu Tyr Met Tyr Gln Arg Ser Ser 
                405                 410                 415     


Ser Trp Trp Pro Leu Gly Leu Thr Tyr Ile Leu Gly Pro Met His Ser 
            420                 425                 430         


Tyr Leu Val Asn Glu Gly Leu Ile Ser Gln Val Thr Leu Ile Ala His 
        435                 440                 445             


Ser Lys Phe Pro Arg Pro Ser Asn Lys Ala Gly Tyr Cys Ala Arg Pro 
    450                 455                 460                 


Ser Val Cys Pro Ala Val Cys Ala Thr Gly Val Tyr Thr Asp Leu Trp 
465                 470                 475                 480 


Pro Ile Thr Glu Ser Ser Asn Ala Ser Asn Ile Val Trp Val Gly Gln 
                485                 490                 495     


Tyr Leu Asp Ala Ile Thr Glu Arg Lys Tyr Pro Arg Ile Gly Val Ala 
            500                 505                 510         


Thr Gln Tyr Asp Trp Ile His Gln Ser Asn Leu Phe Ser Ser Asn Thr 
        515                 520                 525             


Val Ser Ser Tyr Ser Thr Thr Thr Cys Phe Lys Asn Thr Arg Leu Asn 
    530                 535                 540                 


Arg Ser Phe Cys Val Ile Ile Ala Glu Phe Thr Asp Gly Leu Phe Gly 
545                 550                 555                 560 


Glu Tyr Arg Ile Val Pro Gln Leu Ile Glu Leu Arg Val Lys 
                565                 570                 


<210>  330
<211>  577
<212>  PRT
<213>  Avian orthoavulavirus 1

<400>  330

Met Asp Arg Ala Val Ser Gln Val Ala Leu Glu Asn Asp Glu Arg Glu 
1               5                   10                  15      


Ala Lys Asn Thr Trp Arg Leu Ile Phe Arg Ile Ala Ile Leu Phe Leu 
            20                  25                  30          


Thr Val Val Thr Leu Ala Ile Ser Val Ala Ser Leu Leu Tyr Ser Met 
        35                  40                  45              


Gly Ala Ser Thr Pro Ser Asp Leu Val Gly Ile Pro Thr Arg Ile Ser 
    50                  55                  60                  


Arg Ala Glu Glu Lys Ile Thr Ser Thr Leu Gly Ser Asn Gln Asp Val 
65                  70                  75                  80  


Val Asp Arg Ile Tyr Lys Gln Val Ala Leu Glu Ser Pro Leu Ala Leu 
                85                  90                  95      


Leu Asn Thr Glu Thr Thr Ile Met Asn Ala Ile Thr Ser Leu Ser Tyr 
            100                 105                 110         


Gln Ile Asn Gly Ala Ala Asn Asn Ser Gly Trp Gly Ala Pro Ile His 
        115                 120                 125             


Asp Pro Asp Tyr Ile Gly Gly Ile Gly Lys Glu Leu Ile Val Asp Asp 
    130                 135                 140                 


Ala Ser Asp Val Thr Ser Phe Tyr Pro Ser Ala Phe Gln Glu His Leu 
145                 150                 155                 160 


Asn Phe Ile Pro Ala Pro Thr Thr Gly Ser Gly Cys Thr Arg Ile Pro 
                165                 170                 175     


Ser Phe Asp Met Ser Ala Thr His Tyr Cys Tyr Thr His Asn Val Ile 
            180                 185                 190         


Leu Ser Gly Cys Arg Asp His Ser His Ser Tyr Gln Tyr Leu Ala Leu 
        195                 200                 205             


Gly Val Leu Arg Thr Ser Ala Thr Gly Arg Val Phe Phe Ser Thr Leu 
    210                 215                 220                 


Arg Ser Ile Asn Leu Asp Asp Thr Gln Asn Arg Lys Ser Cys Ser Val 
225                 230                 235                 240 


Ser Ala Thr Pro Leu Gly Cys Asp Met Leu Cys Ser Lys Ala Thr Glu 
                245                 250                 255     


Thr Glu Glu Glu Asp Tyr Asn Ser Ala Val Pro Thr Arg Met Val His 
            260                 265                 270         


Gly Arg Leu Gly Phe Asp Gly Gln Tyr His Glu Lys Asp Leu Asp Val 
        275                 280                 285             


Thr Thr Leu Phe Gly Asp Trp Val Ala Asn Tyr Pro Gly Val Gly Gly 
    290                 295                 300                 


Gly Ser Phe Ile Asp Ser Arg Val Trp Phe Ser Val Tyr Gly Gly Leu 
305                 310                 315                 320 


Lys Pro Asn Ser Pro Ser Asp Thr Val Gln Glu Gly Lys Tyr Val Ile 
                325                 330                 335     


Tyr Lys Arg Tyr Asn Asp Thr Cys Pro Asp Glu Gln Asp Tyr Gln Ile 
            340                 345                 350         


Arg Met Ala Lys Ser Ser Tyr Lys Pro Gly Arg Phe Gly Gly Lys Arg 
        355                 360                 365             


Ile Gln Gln Ala Ile Leu Ser Ile Lys Val Ser Thr Ser Leu Gly Glu 
    370                 375                 380                 


Asp Pro Val Leu Thr Val Pro Pro Asn Thr Val Thr Leu Met Gly Ala 
385                 390                 395                 400 


Glu Gly Arg Ile Leu Thr Val Gly Thr Ser His Phe Leu Tyr Gln Arg 
                405                 410                 415     


Gly Ser Ser Tyr Phe Ser Pro Ala Leu Leu Tyr Pro Met Thr Val Ser 
            420                 425                 430         


Asn Lys Thr Ala Thr Leu His Ser Pro Tyr Thr Phe Asn Ala Phe Thr 
        435                 440                 445             


Arg Pro Gly Ser Ile Pro Cys Gln Ala Ser Ala Arg Cys Pro Asn Ser 
    450                 455                 460                 


Cys Val Thr Gly Val Tyr Thr Asp Pro Tyr Pro Leu Ile Phe Tyr Arg 
465                 470                 475                 480 


Asn His Thr Leu Arg Gly Val Phe Gly Thr Met Leu Asp Gly Glu Gln 
                485                 490                 495     


Ala Arg Leu Asn Pro Ala Ser Ala Val Phe Asp Ser Thr Ser Arg Ser 
            500                 505                 510         


Arg Ile Thr Arg Val Ser Ser Ser Ser Ile Lys Ala Ala Tyr Thr Thr 
        515                 520                 525             


Ser Thr Cys Phe Lys Val Val Lys Thr Asn Lys Thr Tyr Cys Leu Ser 
    530                 535                 540                 


Ile Ala Glu Ile Ser Asn Thr Leu Phe Gly Glu Phe Arg Ile Val Pro 
545                 550                 555                 560 


Leu Leu Val Glu Ile Leu Lys Asp Asp Gly Val Arg Glu Ala Arg Ser 
                565                 570                 575     


Gly 
    


<210>  331
<211>  553
<212>  PRT
<213>  Avian orthoavulavirus 1

<400>  331

Met Gly Ser Arg Ser Ser Thr Arg Ile Pro Val Pro Leu Met Leu Thr 
1               5                   10                  15      


Val Arg Ile Met Leu Ala Leu Ser Cys Val Cys Pro Thr Ser Ser Leu 
            20                  25                  30          


Asp Gly Arg Pro Leu Ala Ala Ala Gly Ile Val Val Thr Gly Asp Lys 
        35                  40                  45              


Ala Val Asn Ile Tyr Thr Ser Ser Gln Thr Gly Ser Ile Ile Ile Lys 
    50                  55                  60                  


Leu Leu Pro Asn Met Pro Lys Asp Lys Glu Ala Cys Ala Lys Ala Pro 
65                  70                  75                  80  


Leu Glu Ala Tyr Asn Arg Thr Leu Thr Thr Leu Leu Thr Pro Leu Gly 
                85                  90                  95      


Asp Ser Ile Arg Arg Ile Gln Glu Ser Val Thr Thr Ser Gly Gly Gly 
            100                 105                 110         


Lys Gln Gly Arg Leu Ile Gly Ala Ile Ile Gly Gly Val Ala Leu Gly 
        115                 120                 125             


Val Ala Thr Ala Ala Gln Ile Thr Ala Ala Ser Ala Leu Ile Gln Ala 
    130                 135                 140                 


Asn Gln Asn Ala Ala Asn Ile Leu Arg Leu Lys Glu Ser Ile Ala Ala 
145                 150                 155                 160 


Thr Asn Glu Ala Val His Glu Val Thr Asp Gly Leu Ser Gln Leu Ala 
                165                 170                 175     


Val Ala Val Gly Lys Met Gln Gln Phe Val Asn Asp Gln Phe Asn Lys 
            180                 185                 190         


Thr Ala Gln Glu Leu Asp Cys Ile Lys Ile Thr Gln Gln Val Gly Val 
        195                 200                 205             


Glu Leu Asn Leu Tyr Leu Thr Glu Leu Thr Thr Val Phe Gly Pro Gln 
    210                 215                 220                 


Ile Thr Ser Pro Ala Leu Thr Gln Leu Thr Ile Gln Ala Leu Tyr Asn 
225                 230                 235                 240 


Leu Ala Gly Gly Asn Met Asp Tyr Leu Leu Thr Lys Leu Gly Val Gly 
                245                 250                 255     


Asn Asn Gln Leu Ser Ser Leu Ile Gly Ser Gly Leu Ile Thr Gly Asn 
            260                 265                 270         


Pro Ile Leu Tyr Asp Ser Gln Thr Gln Leu Leu Gly Ile Gln Val Thr 
        275                 280                 285             


Leu Pro Ser Val Gly Asn Leu Asn Asn Met Arg Ala Thr Tyr Leu Glu 
    290                 295                 300                 


Thr Leu Ser Val Ser Thr Thr Lys Gly Phe Ala Ser Ala Leu Val Pro 
305                 310                 315                 320 


Lys Val Val Thr Gln Val Gly Ser Val Ile Glu Glu Leu Asp Thr Ser 
                325                 330                 335     


Tyr Cys Ile Glu Thr Asp Leu Asp Leu Tyr Cys Thr Arg Ile Val Thr 
            340                 345                 350         


Phe Pro Met Ser Pro Gly Ile Tyr Ser Cys Leu Ser Gly Asn Thr Ser 
        355                 360                 365             


Ala Cys Met Tyr Ser Lys Thr Glu Gly Ala Leu Thr Thr Pro Tyr Met 
    370                 375                 380                 


Thr Leu Lys Gly Ser Val Ile Ala Asn Cys Lys Met Thr Thr Cys Arg 
385                 390                 395                 400 


Cys Ala Asp Pro Pro Gly Ile Ile Ser Gln Asn Tyr Gly Glu Ala Val 
                405                 410                 415     


Ser Leu Ile Asp Arg Gln Ser Cys Asn Ile Leu Ser Leu Asp Gly Ile 
            420                 425                 430         


Thr Leu Arg Leu Ser Gly Glu Phe Asp Ala Thr Tyr Gln Lys Asn Ile 
        435                 440                 445             


Ser Ile Gln Asp Ser Gln Val Ile Val Thr Gly Asn Leu Asp Ile Ser 
    450                 455                 460                 


Thr Glu Leu Gly Asn Val Asn Asn Ser Ile Ser Asn Ala Leu Asp Lys 
465                 470                 475                 480 


Leu Glu Glu Ser Asn Ser Lys Leu Asp Lys Val Asn Val Lys Leu Thr 
                485                 490                 495     


Ser Thr Ser Ala Leu Ile Thr Tyr Ile Phe Leu Thr Val Ile Ser Leu 
            500                 505                 510         


Val Cys Gly Ile Leu Ser Leu Val Leu Ala Cys Tyr Leu Met Tyr Lys 
        515                 520                 525             


Gln Lys Ala Gln Gln Lys Thr Leu Leu Trp Leu Gly Asn Asn Thr Leu 
    530                 535                 540                 


Asp Gln Met Arg Ala Thr Thr Lys Met 
545                 550             


<210>  332
<211>  620
<212>  PRT
<213>  Avian orthoavulavirus 9

<400>  332

Met Glu Pro Gly Ile Ser Gln Ala Ser Leu Val Asn Asp Asn Ile Glu 
1               5                   10                  15      


Leu Arg Asn Thr Trp Arg Thr Ala Phe Arg Ile Leu Ser Leu Leu Leu 
            20                  25                  30          


Gly Phe Thr Gly Leu Ile Leu Ala Ala Cys Ala Leu His Phe Ala Leu 
        35                  40                  45              


Asn Ala Ala Thr Pro Ala Asp Leu Ser Gly Ile Pro Val Ala Ile Asp 
    50                  55                  60                  


Gln Asn Arg Arg Glu Ile Leu Gln Thr Leu Ser Leu Met Ser Asp Thr 
65                  70                  75                  80  


Asp Asn Lys Ile Tyr Lys Gln Val Ala Leu Glu Ser Pro Val Ala Leu 
                85                  90                  95      


Leu Asn Thr Glu Ser Thr Leu Met Ser Ala Ile Thr Ser Leu Ser Tyr 
            100                 105                 110         


Gln Ile Asn Asn Ala Ala Asn Asn Ser Gly Cys Gly Ala Pro Val His 
        115                 120                 125             


Asp Lys Asp Phe Ile Asn Gly Val Ala Lys Glu Leu Phe Val Gly Pro 
    130                 135                 140                 


Gln Tyr Asn Ala Ser Asn Tyr Arg Pro Ser Lys Phe Leu Glu His Leu 
145                 150                 155                 160 


Asn Phe Ile Pro Ala Pro Thr Thr Gly Asn Gly Cys Thr Arg Ile Pro 
                165                 170                 175     


Ser Phe Asp Leu Ala Ala Thr His Trp Cys Tyr Thr His Asn Val Ile 
            180                 185                 190         


Leu Ser Gly Cys Asn Asp His Val His Ser Tyr Gln Tyr Ile Ser Leu 
        195                 200                 205             


Gly Ile Leu Lys Val Ser Ala Thr Gly Asn Val Phe Leu Ser Thr Leu 
    210                 215                 220                 


Arg Ser Ile Asn Leu Asp Asp Asp Glu Asn Arg Lys Ser Cys Ser Ile 
225                 230                 235                 240 


Ser Ala Thr Pro Leu Gly Cys Asp Leu Leu Cys Ala Lys Val Thr Glu 
                245                 250                 255     


Thr Glu Glu Glu Asp Tyr Asn Ser Asp Ala Ala Thr Lys Leu Val His 
            260                 265                 270         


Gly Arg Leu Gly Phe Asp Gly Ala Tyr His Glu Gln Ala Leu Pro Val 
        275                 280                 285             


Glu Ser Leu Phe Ser Asp Trp Val Ala Asn Tyr Pro Thr Val Gly Gly 
    290                 295                 300                 


Gly Ser Tyr Phe Asp Asn Arg Val Trp Phe Gly Val Tyr Gly Gly Ile 
305                 310                 315                 320 


Arg Pro Gly Ser Gln Thr Asp Leu Leu Gln Ser Gly Lys Tyr Ala Ile 
                325                 330                 335     


Tyr His Arg Tyr Asn Asn Thr Cys Pro Asp Asp Asn Ser Thr Gln Ile 
            340                 345                 350         


Glu Arg Ala Arg Ser Ser Tyr Arg Pro Gln Arg Phe Gly Gln Arg Leu 
        355                 360                 365             


Val Gln Gln Ala Ile Leu Ser Ile Arg Val Glu Ser Ser Leu Gly Gly 
    370                 375                 380                 


Asp Pro Lys Leu Ser Val Leu Asp Asn Thr Val Val Leu Met Gly Ala 
385                 390                 395                 400 


Glu Ala Arg Ile Met Thr Phe Gly His Val Ala Leu Met Tyr Gln Arg 
                405                 410                 415     


Gly Ser Ser Tyr Phe Pro Ser Ala Leu Leu Tyr Pro Leu Ser Leu Thr 
            420                 425                 430         


Asn Gly Ser Ala Thr Ala Ser Lys Pro Tyr Ile Phe Glu Gln Tyr Thr 
        435                 440                 445             


Arg Pro Gly Ser Pro Pro Cys Gln Ala Thr Ala Arg Cys Pro Asn Ser 
    450                 455                 460                 


Cys Val Thr Gly Val Tyr Thr Asp Ala Tyr Pro Leu Phe Trp Ser Asp 
465                 470                 475                 480 


Asp His Lys Val Thr Gly Val Tyr Gly Met Met Leu Asp Asp Asn Thr 
                485                 490                 495     


Leu Arg Leu Asn Pro Val Ala Ala Val Phe Asn Arg Tyr Asp Arg Ser 
            500                 505                 510         


Gly Val Thr Arg Val Ser Ser Ser Ser Thr Lys Ala Ala Tyr Thr Thr 
        515                 520                 525             


Asn Thr Cys Phe Lys Val Val Lys Thr Lys Arg Val Tyr Cys Leu Ser 
    530                 535                 540                 


Ile Ala Glu Ile Gly Asn Thr Leu Phe Gly Glu Phe Arg Ile Thr Pro 
545                 550                 555                 560 


Leu Leu Ser Glu Ile Ile Leu Asp Pro Ser Leu Glu Thr Ser Asp Lys 
                565                 570                 575     


Ser Arg Asn Arg Val Lys Ser Ala Pro Glu Asp Gly Gly Trp Thr Asp 
            580                 585                 590         


Pro Ala Ser Ile Ala Leu Thr Ala Gly Asn Ala Ser Ser Leu His Ser 
        595                 600                 605             


Asn Val Thr Ser Ala Gly Ser Val Asp Ser Gln Pro 
    610                 615                 620 


<210>  333
<211>  551
<212>  PRT
<213>  Avian orthoavulavirus 9

<400>  333

Met Gly His Leu His Leu Leu Tyr Ile Met Ile Val Ile Thr Met Ser 
1               5                   10                  15      


Ala His Leu Cys Cys Thr Thr Ser Leu Asp Gly Arg Lys Leu Leu Gly 
            20                  25                  30          


Ala Gly Ile Val Ile Thr Glu Glu Lys Gln Val Arg Val Tyr Thr Ala 
        35                  40                  45              


Ala Gln Ser Gly Thr Ile Val Leu Arg Leu Leu Pro Tyr Leu Ser Ser 
    50                  55                  60                  


Asp Arg Tyr Pro Cys Val Glu Ser Thr Ile Glu Ser Tyr Asn Lys Thr 
65                  70                  75                  80  


Val Tyr Asn Ile Leu Ala Pro Leu Gly Asp Ala Ile Arg Arg Ile Gln 
                85                  90                  95      


Ala Ser Asp Val Ser Val Glu Ser Ile Arg Glu Gly Arg Ile Phe Gly 
            100                 105                 110         


Ala Ile Leu Gly Gly Val Ala Leu Gly Val Ala Thr Ala Ala Gln Ile 
        115                 120                 125             


Thr Ala Ala Ser Ala Leu Ile Gln Ala Asn Glu Asn Ala Lys Asn Ile 
    130                 135                 140                 


Leu Arg Ile Lys Asp Ser Ile Thr Lys Thr Asn Glu Ala Val Arg Asp 
145                 150                 155                 160 


Val Thr Glu Gly Val Ser Gln Leu Thr Ile Ala Val Gly Lys Leu Gln 
                165                 170                 175     


Asp Phe Val Asn Lys Glu Phe Asn Lys Thr Thr Glu Ala Ile Asn Cys 
            180                 185                 190         


Val Gln Ala Ala Gln Gln Leu Gly Val Glu Leu Ser Leu Tyr Leu Thr 
        195                 200                 205             


Glu Ile Thr Thr Val Phe Gly Pro Gln Ile Thr Ser Pro Ala Leu Ser 
    210                 215                 220                 


Lys Leu Thr Ile Gln Ala Leu Tyr Asn Leu Ala Gly Gly Asp Leu Asp 
225                 230                 235                 240 


Val Leu Leu Gly Lys Leu Gly Ala Asp Asn Ser Gln Leu Ser Ser Leu 
                245                 250                 255     


Ile Ser Ser Gly Leu Ile Thr Gly Gln Pro Ile Leu Tyr Asp Ser Glu 
            260                 265                 270         


Ser Gln Ile Leu Ala Leu Gln Val Ser Leu Pro Ser Ile Gly Asp Leu 
        275                 280                 285             


Arg Gly Val Arg Ala Thr Tyr Leu Asp Thr Leu Ala Val Asp Thr Ala 
    290                 295                 300                 


Ala Gly Leu Ala Ser Ala Met Ile Pro Lys Val Val Ile Gln Ser Asn 
305                 310                 315                 320 


Asn Ile Val Glu Glu Leu Asp Thr Thr Thr Cys Ile Ala Ala Glu Ala 
                325                 330                 335     


Asp Leu Tyr Cys Thr Lys Ile Thr Thr Phe Pro Ile Ala Ser Ala Val 
            340                 345                 350         


Ser Ala Cys Ile Leu Gly Asp Val Ser Gln Cys Leu Tyr Ser Lys Thr 
        355                 360                 365             


Asn Gly Ala Leu Thr Thr Pro Tyr Val Ala Val Lys Gly Lys Ile Val 
    370                 375                 380                 


Ala Asn Cys Lys His Val Thr Cys Arg Cys Val Asn Pro Thr Ala Ile 
385                 390                 395                 400 


Ile Ser Gln Asn Tyr Gly Glu Ala Ala Thr Leu Ile Asp Asp Gln Leu 
                405                 410                 415     


Cys Lys Val Ile Asn Leu Asp Gly Val Ser Ile Gln Leu Ser Gly Thr 
            420                 425                 430         


Phe Glu Ser Thr Tyr Val Arg Asn Ile Ser Ile Ser Ala Asn Lys Val 
        435                 440                 445             


Ile Val Ser Ser Ser Ile Asp Ile Ser Asn Glu Leu Glu Asn Val Asn 
    450                 455                 460                 


Ser Ser Leu Ser Ser Ala Leu Asp Lys Leu Asp Glu Ser Asp Ala Ala 
465                 470                 475                 480 


Leu Ser Lys Val Asn Val His Leu Thr Ser Thr Ser Ala Met Ile Thr 
                485                 490                 495     


Tyr Ile Val Leu Thr Val Ile Ala Leu Val Leu Gly Val Val Gly Leu 
            500                 505                 510         


Gly Leu Gly Cys Phe Ala Met Ile Lys Val Lys Ser Gln Ala Lys Thr 
        515                 520                 525             


Leu Leu Trp Leu Gly Ala His Ala Asp Arg Ser Tyr Ile Leu Gln Asn 
    530                 535                 540                 


Lys Pro Ala Gln Ser Ser Thr 
545                 550     


<210>  334
<211>  577
<212>  PRT
<213>  Avian orthoavulavirus 12

<400>  334

Met Asp Arg Ala Val Ser Gln Val Ala Leu Glu Asn Asp Glu Arg Glu 
1               5                   10                  15      


Ala Lys Asn Thr Trp Arg Leu Ile Phe Arg Ile Ala Ile Leu Phe Leu 
            20                  25                  30          


Thr Val Val Thr Leu Ala Ile Ser Val Ala Ser Leu Leu Tyr Ser Met 
        35                  40                  45              


Gly Ala Ser Thr Pro Ser Asp Leu Val Gly Ile Pro Thr Arg Ile Ser 
    50                  55                  60                  


Arg Ala Glu Glu Lys Ile Thr Ser Thr Leu Gly Ser Asn Gln Asp Val 
65                  70                  75                  80  


Val Asp Arg Ile Tyr Lys Gln Val Ala Leu Glu Ser Pro Leu Ala Leu 
                85                  90                  95      


Leu Asn Thr Glu Thr Thr Ile Met Asn Ala Ile Thr Ser Leu Ser Tyr 
            100                 105                 110         


Gln Ile Asn Gly Ala Ala Asn Asn Ser Gly Trp Gly Ala Pro Ile His 
        115                 120                 125             


Asp Pro Asp Tyr Ile Gly Gly Ile Gly Lys Glu Leu Ile Val Asp Asp 
    130                 135                 140                 


Ala Ser Asp Val Thr Ser Phe Tyr Pro Ser Ala Phe Gln Glu His Leu 
145                 150                 155                 160 


Asn Phe Ile Pro Ala Pro Thr Thr Gly Ser Gly Cys Thr Arg Ile Pro 
                165                 170                 175     


Ser Phe Asp Met Ser Ala Thr His Tyr Cys Tyr Thr His Asn Val Ile 
            180                 185                 190         


Leu Ser Gly Cys Arg Asp His Ser His Ser Tyr Gln Tyr Leu Ala Leu 
        195                 200                 205             


Gly Val Leu Arg Thr Ser Ala Thr Gly Arg Val Phe Phe Ser Thr Leu 
    210                 215                 220                 


Arg Ser Ile Asn Leu Asp Asp Thr Gln Asn Arg Lys Ser Cys Ser Val 
225                 230                 235                 240 


Ser Ala Thr Pro Leu Gly Cys Asp Met Leu Cys Ser Lys Ala Thr Glu 
                245                 250                 255     


Thr Glu Glu Glu Asp Tyr Asn Ser Ala Val Pro Thr Arg Met Val His 
            260                 265                 270         


Gly Arg Leu Gly Phe Asp Gly Gln Tyr His Glu Lys Asp Leu Asp Val 
        275                 280                 285             


Thr Thr Leu Phe Gly Asp Trp Val Ala Asn Tyr Pro Gly Val Gly Gly 
    290                 295                 300                 


Gly Ser Phe Ile Asp Ser Arg Val Trp Phe Ser Val Tyr Gly Gly Leu 
305                 310                 315                 320 


Lys Pro Asn Ser Pro Ser Asp Thr Val Gln Glu Gly Lys Tyr Val Ile 
                325                 330                 335     


Tyr Lys Arg Tyr Asn Asp Thr Cys Pro Asp Glu Gln Asp Tyr Gln Ile 
            340                 345                 350         


Arg Met Ala Lys Ser Ser Tyr Lys Pro Gly Arg Phe Gly Gly Lys Arg 
        355                 360                 365             


Ile Gln Gln Ala Ile Leu Ser Ile Lys Val Ser Thr Ser Leu Gly Glu 
    370                 375                 380                 


Asp Pro Val Leu Thr Val Pro Pro Asn Thr Val Thr Leu Met Gly Ala 
385                 390                 395                 400 


Glu Gly Arg Ile Leu Thr Val Gly Thr Ser His Phe Leu Tyr Gln Arg 
                405                 410                 415     


Gly Ser Ser Tyr Phe Ser Pro Ala Leu Leu Tyr Pro Met Thr Val Ser 
            420                 425                 430         


Asn Lys Thr Ala Thr Leu His Ser Pro Tyr Thr Phe Asn Ala Phe Thr 
        435                 440                 445             


Arg Pro Gly Ser Ile Pro Cys Gln Ala Ser Ala Arg Cys Pro Asn Ser 
    450                 455                 460                 


Cys Val Thr Gly Val Tyr Thr Asp Pro Tyr Pro Leu Ile Phe Tyr Arg 
465                 470                 475                 480 


Asn His Thr Leu Arg Gly Val Phe Gly Thr Met Leu Asp Gly Glu Gln 
                485                 490                 495     


Ala Arg Leu Asn Pro Ala Ser Ala Val Phe Asp Ser Thr Ser Arg Ser 
            500                 505                 510         


Arg Ile Thr Arg Val Ser Ser Ser Ser Ile Lys Ala Ala Tyr Thr Thr 
        515                 520                 525             


Ser Thr Cys Phe Lys Val Val Lys Thr Asn Lys Thr Tyr Cys Leu Ser 
    530                 535                 540                 


Ile Ala Glu Ile Ser Asn Thr Leu Phe Gly Glu Phe Arg Ile Val Pro 
545                 550                 555                 560 


Leu Leu Val Glu Ile Leu Lys Asp Asp Gly Val Arg Glu Ala Arg Ser 
                565                 570                 575     


Gly 
    


<210>  335
<211>  546
<212>  PRT
<213>  Avian orthoavulavirus 12

<400>  335

Met Ala Ile Pro Val Pro Ser Ser Thr Ala Leu Met Ile Phe Asn Ile 
1               5                   10                  15      


Leu Val Ser Leu Ala Pro Ala Ser Ala Leu Asp Gly Arg Leu Leu Leu 
            20                  25                  30          


Gly Ala Gly Ile Val Pro Thr Gly Asp Arg Gln Val Asn Val Tyr Thr 
        35                  40                  45              


Ser Ser Gln Thr Gly Ile Ile Ala Leu Lys Leu Leu Pro Asn Leu Pro 
    50                  55                  60                  


Lys Asp Lys Glu Asn Cys Ala Glu Val Ser Ile Arg Ser Tyr Asn Glu 
65                  70                  75                  80  


Thr Leu Thr Arg Ile Leu Thr Pro Leu Ala Gln Ser Met Ala Ala Ile 
                85                  90                  95      


Arg Gly Asn Ser Thr Val Ser Thr Arg Gly Arg Glu Pro Arg Leu Val 
            100                 105                 110         


Gly Ala Ile Ile Gly Gly Val Ala Leu Gly Val Ala Thr Ala Ala Gln 
        115                 120                 125             


Ile Thr Ala Ala Thr Ala Leu Ile Gln Ala Asn Gln Asn Ala Glu Asn 
    130                 135                 140                 


Ile Ala Arg Leu Ala Lys Gly Leu Ala Ala Thr Asn Glu Ala Val Thr 
145                 150                 155                 160 


Asp Leu Thr Lys Gly Val Gly Ser Leu Ala Ile Gly Val Gly Lys Leu 
                165                 170                 175     


Gln Asp Tyr Val Asn Glu Gln Phe Asn Arg Thr Gly Glu Ala Ile Glu 
            180                 185                 190         


Cys Leu Thr Ile Glu Ser Arg Val Gly Val Gln Leu Ser Leu Tyr Leu 
        195                 200                 205             


Thr Glu Val Ile Gly Val Phe Gly Asp Gln Ile Thr Ser Pro Ala Leu 
    210                 215                 220                 


Ser Asp Ile Ser Ile Gln Ala Leu Tyr Asn Leu Ala Gly Gly Asn Leu 
225                 230                 235                 240 


Asn Val Leu Leu Gln Lys Met Gly Ile Glu Gly Thr Gln Leu Gly Ser 
                245                 250                 255     


Leu Ile Asn Ser Gly Leu Ile Lys Gly Arg Pro Ile Met Tyr Asp Asp 
            260                 265                 270         


Gly Asn Lys Ile Leu Gly Ile Gln Val Thr Leu Pro Ser Val Gly Arg 
        275                 280                 285             


Ile Asn Gly Ala Arg Ala Thr Leu Leu Glu Ala Ile Ala Val Ala Thr 
    290                 295                 300                 


Pro Lys Gly Asn Ala Ser Pro Leu Ile Pro Arg Ala Val Ile Ser Val 
305                 310                 315                 320 


Gly Ser Leu Val Glu Glu Leu Asp Met Thr Pro Cys Val Leu Thr Pro 
                325                 330                 335     


Thr Asp Ile Phe Cys Thr Arg Ile Leu Ser Tyr Pro Leu Ser Asp Ser 
            340                 345                 350         


Leu Thr Thr Cys Leu Lys Gly Asn Leu Ser Ser Cys Val Phe Ser Arg 
        355                 360                 365             


Thr Glu Gly Ala Leu Ser Thr Pro Tyr Val Ser Val His Gly Lys Ile 
    370                 375                 380                 


Val Ala Asn Cys Lys Ser Val Val Cys Arg Cys Val Glu Pro Gln Gln 
385                 390                 395                 400 


Ile Ile Ser Gln Asn Tyr Gly Glu Ala Leu Ser Leu Ile Asp Glu Ser 
                405                 410                 415     


Leu Cys Arg Ile Leu Glu Leu Asn Gly Val Ile Leu Lys Met Asp Gly 
            420                 425                 430         


Gln Phe Thr Ser Glu Tyr Thr Lys Asn Ile Thr Ile Asp Pro Val Gln 
        435                 440                 445             


Val Ile Ile Ser Gly Pro Ile Asp Ile Ser Ser Glu Leu Ser Gln Val 
    450                 455                 460                 


Asn Gln Ser Leu Asp Ser Ala Leu Glu Asn Ile Lys Glu Ser Asn Ser 
465                 470                 475                 480 


Tyr Leu Ser Lys Val Asn Val Lys Leu Ile Ser Ser Ser Ala Met Ile 
                485                 490                 495     


Thr Tyr Ile Val Ile Thr Val Ile Cys Leu Ile Leu Thr Phe Val Ala 
            500                 505                 510         


Leu Val Leu Gly Ile Tyr Ser Tyr Thr Lys Ile Arg Ser Gln Gln Lys 
        515                 520                 525             


Thr Leu Ile Trp Met Gly Asn Asn Ile Ala Arg Ser Lys Glu Gly Asn 
    530                 535                 540                 


Arg Phe 
545     


<210>  336
<211>  579
<212>  PRT
<213>  Avian orthoavulavirus 13

<400>  336

Met Gln Pro Gly Ile Ser Glu Val Ser Phe Val Asn Asp Glu Arg Ser 
1               5                   10                  15      


Glu Arg Gly Thr Trp Arg Leu Leu Phe Arg Ile Leu Thr Ile Val Leu 
            20                  25                  30          


Cys Leu Thr Ser Ile Gly Ile Gly Ile Pro Ala Leu Ile Tyr Ser Lys 
        35                  40                  45              


Glu Ala Ala Thr Ser Gly Asp Ile Asp Lys Ser Leu Glu Ala Val Lys 
    50                  55                  60                  


Thr Gly Met Ser Thr Leu Ser Ser Lys Ile Asp Glu Ser Ile Asn Thr 
65                  70                  75                  80  


Glu Gln Lys Ile Tyr Arg Gln Val Ile Leu Glu Ala Pro Val Ser Gln 
                85                  90                  95      


Leu Asn Met Glu Ser Asn Ile Leu Ser Ala Ile Ala Ser Leu Ser Tyr 
            100                 105                 110         


Gln Ile Asp Gly Thr Ser Asn Ser Ser Gly Cys Gly Ser Pro Met His 
        115                 120                 125             


Asp Gln Asp Phe Val Gly Gly Ile Asn Lys Glu Ile Trp Thr Thr Asp 
    130                 135                 140                 


Asn Val Asn Leu Gly Glu Ile Thr Leu Thr Pro Phe Leu Glu His Leu 
145                 150                 155                 160 


Asn Phe Ile Pro Ala Pro Thr Thr Gly Asn Gly Cys Thr Arg Ile Pro 
                165                 170                 175     


Ser Phe Asp Leu Gly Leu Thr His Trp Cys Tyr Thr His Asn Val Ile 
            180                 185                 190         


Leu Ser Gly Cys Gln Asp Tyr Ser Ser Ser Phe Gln Tyr Ile Ala Leu 
        195                 200                 205             


Gly Val Leu Lys Ile Ser Ala Thr Gly His Val Phe Leu Ser Thr Met 
    210                 215                 220                 


Arg Ser Ile Asn Leu Asp Asp Glu Arg Asn Arg Lys Ser Cys Ser Ile 
225                 230                 235                 240 


Ser Ala Thr Ser Ile Gly Cys Asp Ile Ile Cys Ser Leu Val Thr Glu 
                245                 250                 255     


Arg Glu Val Asp Asp Tyr Asn Ser Pro Ala Ala Thr Pro Met Ile His 
            260                 265                 270         


Gly Arg Leu Asp Phe Ser Gly Lys Tyr Asn Glu Val Asp Leu Asn Val 
        275                 280                 285             


Gly Gln Leu Phe Gly Asp Trp Ser Ala Asn Tyr Pro Gly Val Gly Gly 
    290                 295                 300                 


Gly Ser Phe Leu Asn Gly Arg Val Trp Phe Pro Ile Tyr Gly Gly Val 
305                 310                 315                 320 


Lys Glu Gly Thr Pro Thr Phe Lys Glu Asn Asp Gly Lys Tyr Ala Ile 
                325                 330                 335     


Tyr Thr Arg Tyr Asn Asp Thr Cys Pro Asp Ser Glu Ser Glu Gln Val 
            340                 345                 350         


Ser Arg Ala Lys Ser Ser Tyr Arg Pro Ser Tyr Phe Gly Gly Lys Leu 
        355                 360                 365             


Val Gln Gln Ala Val Leu Ser Ile Lys Ile Asp Asp Thr Leu Gly Leu 
    370                 375                 380                 


Asp Pro Val Leu Thr Ile Ser Asn Asn Ser Ile Thr Leu Met Gly Ala 
385                 390                 395                 400 


Glu Ser Arg Val Leu Gln Ile Glu Gly Lys Leu Tyr Phe Tyr Gln Arg 
                405                 410                 415     


Gly Thr Ser Trp Phe Pro Ser Leu Val Met Tyr Pro Leu Thr Val Asn 
            420                 425                 430         


Asp Lys Met Val Arg Phe Glu Pro Pro Thr Ile Phe Asp Gln Phe Thr 
        435                 440                 445             


Arg Pro Gly Asn His Pro Cys Ser Ala Asp Ser Arg Cys Pro Asn Ala 
    450                 455                 460                 


Cys Val Thr Gly Val Tyr Thr Asp Gly Tyr Pro Ile Val Phe His Ser 
465                 470                 475                 480 


Asn His Ser Ile Ala Ala Val Tyr Gly Met Gln Leu Asn Asp Val Thr 
                485                 490                 495     


Asn Arg Leu Asn Pro Arg Ser Ala Val Trp Tyr Gly Val Ser Met Ser 
            500                 505                 510         


Asn Val Ile Arg Val Ser Ser Ser Thr Thr Lys Ala Ala Tyr Thr Thr 
        515                 520                 525             


Ser Thr Cys Phe Lys Val Lys Lys Thr Gln Arg Val Tyr Cys Leu Ser 
    530                 535                 540                 


Ile Gly Glu Ile Gly Asn Thr Leu Phe Gly Glu Phe Arg Ile Val Pro 
545                 550                 555                 560 


Leu Leu Leu Glu Val Tyr Ser Glu Lys Gly Lys Ser Leu Lys Ser Gly 
                565                 570                 575     


Phe Asp Gly 
            


<210>  337
<211>  545
<212>  PRT
<213>  Avian orthoavulavirus 13

<400>  337

Met Ala Arg Phe Ser Trp Glu Ile Phe Arg Leu Ser Thr Ile Leu Leu 
1               5                   10                  15      


Ile Ala Gln Thr Cys Gln Gly Ser Ile Asp Gly Arg Leu Thr Leu Ala 
            20                  25                  30          


Ala Gly Ile Val Pro Val Gly Asp Arg Pro Ile Ser Ile Tyr Thr Ser 
        35                  40                  45              


Ser Gln Thr Gly Ile Ile Val Val Lys Leu Ile Pro Asn Leu Pro Asp 
    50                  55                  60                  


Asn Lys Lys Asp Cys Ala Lys Gln Ser Leu Gln Ser Tyr Asn Glu Thr 
65                  70                  75                  80  


Leu Ser Arg Ile Leu Thr Pro Leu Ala Thr Ala Met Ser Ala Ile Arg 
                85                  90                  95      


Gly Asn Ser Thr Thr Gln Val Arg Glu Asn Arg Leu Val Gly Ala Ile 
            100                 105                 110         


Ile Gly Ser Val Ala Leu Gly Val Ala Thr Ala Ala Gln Ile Thr Ala 
        115                 120                 125             


Ala Thr Ala Leu Ile Gln Ala Asn Gln Asn Ala Ala Asn Ile Ala Arg 
    130                 135                 140                 


Leu Ala Asn Ser Ile Ala Lys Thr Asn Glu Ala Val Thr Asp Leu Thr 
145                 150                 155                 160 


Glu Gly Leu Gly Thr Leu Ala Ile Gly Val Gly Lys Leu Gln Asp Tyr 
                165                 170                 175     


Val Asn Glu Gln Phe Asn Asn Thr Ala Val Ala Ile Asp Cys Leu Thr 
            180                 185                 190         


Leu Glu Ser Arg Leu Gly Ile Gln Leu Ser Leu Tyr Leu Thr Glu Leu 
        195                 200                 205             


Met Gly Val Phe Gly Asn Gln Leu Thr Ser Pro Ala Leu Thr Pro Ile 
    210                 215                 220                 


Thr Ile Gln Ala Leu Tyr Asn Leu Ala Gly Gly Asn Leu Asn Ala Leu 
225                 230                 235                 240 


Leu Ser Arg Leu Gly Ala Ser Glu Thr Gln Leu Gly Ser Leu Ile Asn 
                245                 250                 255     


Ser Gly Leu Ile Lys Gly Met Pro Ile Met Tyr Asp Asp Ala Asn Lys 
            260                 265                 270         


Leu Leu Ala Val Gln Val Glu Leu Pro Ser Ile Gly Lys Leu Asn Gly 
        275                 280                 285             


Ala Arg Ser Thr Leu Leu Glu Thr Leu Ala Val Asp Thr Thr Arg Gly 
    290                 295                 300                 


Pro Ser Ser Pro Ile Ile Pro Ser Ala Val Ile Glu Ile Gly Gly Ala 
305                 310                 315                 320 


Met Glu Glu Leu Asp Leu Ser Pro Cys Ile Thr Thr Asp Leu Asp Met 
                325                 330                 335     


Phe Cys Thr Lys Ile Ile Ser Tyr Pro Leu Ser Gln Ser Thr Leu Ser 
            340                 345                 350         


Cys Leu Asn Gly Asn Leu Ser Asp Cys Val Phe Ser Arg Ser Glu Gly 
        355                 360                 365             


Val Leu Ser Thr Pro Tyr Met Thr Ile Lys Gly Lys Ile Val Ala Asn 
    370                 375                 380                 


Cys Lys Gln Val Ile Cys Arg Cys Met Asp Pro Pro Gln Ile Leu Ser 
385                 390                 395                 400 


Gln Asn Tyr Gly Glu Ala Leu Leu Leu Ile Asp Glu Asn Thr Cys Arg 
                405                 410                 415     


Ser Leu Glu Leu Ser Gly Val Ile Leu Lys Leu Ala Gly Thr Tyr Glu 
            420                 425                 430         


Ser Glu Tyr Thr Arg Asn Leu Thr Val Asp Pro Ser Gln Val Ile Ile 
        435                 440                 445             


Thr Gly Pro Leu Asp Ile Ser Ala Glu Leu Ser Lys Val Asn Gln Ser 
    450                 455                 460                 


Ile Asp Ser Ala Lys Glu Asn Ile Ala Glu Ser Asn Lys Phe Leu Ser 
465                 470                 475                 480 


Gln Val Asn Val Lys Leu Leu Ser Ser Ser Ala Met Ile Thr Tyr Ile 
                485                 490                 495     


Val Ala Thr Val Val Cys Leu Ile Ile Ala Ile Thr Gly Cys Val Ile 
            500                 505                 510         


Gly Ile Tyr Thr Leu Thr Lys Leu Lys Ser Gln Gln Lys Thr Leu Leu 
        515                 520                 525             


Trp Leu Gly Asn Asn Ala Glu Met His Gly Ser Arg Ser Lys Thr Ser 
    530                 535                 540                 


Phe 
545 


<210>  338
<211>  618
<212>  PRT
<213>  Avian orthoavulavirus 16

<400>  338

Met Glu Arg Gly Ile Ser Glu Val Ala Leu Ala Asn Asp Arg Thr Glu 
1               5                   10                  15      


Glu Lys Asn Thr Trp Arg Leu Ile Phe Arg Ile Thr Val Leu Val Val 
            20                  25                  30          


Ser Val Ile Thr Leu Gly Leu Thr Ala Ala Ser Leu Val Tyr Ser Met 
        35                  40                  45              


Asn Ala Ala Gln Pro Ala Asp Phe Asp Gly Ile Ile Pro Ala Val Gln 
    50                  55                  60                  


Gln Val Gly Thr Leu Leu Thr Asn Ser Ile Gly Gly Met Gln Asp Val 
65                  70                  75                  80  


Leu Asp Arg Thr Tyr Lys Gln Val Ala Leu Glu Ser Pro Leu Thr Leu 
                85                  90                  95      


Leu Asn Met Glu Ser Thr Ile Met Asn Ala Ile Thr Ser Leu Ser Tyr 
            100                 105                 110         


Gln Ile Asn Asn Gly Gly Asn Ser Ser Gly Cys Gly Ala Pro Ile His 
        115                 120                 125             


Asp Pro Glu Tyr Ile Gly Gly Ile Gly Lys Glu Leu Leu Ile Asp Asp 
    130                 135                 140                 


Asn Ile Asp Val Thr Ser Phe Tyr Pro Ser Ala Phe Lys Glu His Leu 
145                 150                 155                 160 


Asn Phe Ile Pro Ala Pro Thr Thr Gly Ala Gly Cys Thr Arg Ile Pro 
                165                 170                 175     


Ser Phe Asp Leu Ser Ala Thr His Tyr Cys Tyr Thr His Asn Val Ile 
            180                 185                 190         


Leu Ser Gly Cys Gln Asp His Ser Arg Ser His Gln Tyr Ile Ala Leu 
        195                 200                 205             


Gly Val Leu Lys Leu Ser Asp Thr Gly Asn Val Phe Phe Ser Thr Leu 
    210                 215                 220                 


His Ser Ile Asn Leu Asp Asp Thr Ala Asn Arg Lys Ser Cys Ser Ile 
225                 230                 235                 240 


Ser Ala Thr Pro Leu Gly Cys Asp Ile Leu Cys Ser Lys Val Thr Glu 
                245                 250                 255     


Thr Glu Leu Glu Asp Tyr Lys Ser Glu Glu Pro Thr Pro Met Val His 
            260                 265                 270         


Gly Arg Leu Ser Phe Asp Gly Thr Tyr Ser Glu Lys Asp Leu Asp Val 
        275                 280                 285             


Asn Asn Leu Phe Ser Asp Trp Thr Ala Asn Tyr Pro Gly Val Gly Gly 
    290                 295                 300                 


Gly Ser Tyr Ile Gly Asn Arg Val Trp Tyr Ala Val Tyr Gly Gly Leu 
305                 310                 315                 320 


Lys Pro Gly Ser Asn Thr Asp Gln Ser Gln Arg Asp Lys Tyr Val Ile 
                325                 330                 335     


Tyr Lys Arg Tyr Asn Asn Thr Cys Pro Asp Pro Glu Asp Tyr Gln Ile 
            340                 345                 350         


Asn Lys Ala Lys Ser Ser Tyr Thr Pro Ser Tyr Phe Gly Ser Lys Arg 
        355                 360                 365             


Val Gln Gln Ala Ile Leu Ser Ile Ala Val Ser Pro Thr Leu Gly Ser 
    370                 375                 380                 


Asp Pro Val Leu Thr Pro Leu Ser Asn Asp Val Val Leu Met Gly Ala 
385                 390                 395                 400 


Glu Gly Arg Val Met His Val Gly Gly Tyr Thr Tyr Leu Tyr Gln Arg 
                405                 410                 415     


Gly Thr Ser Tyr Tyr Ser Pro Ala Leu Leu Tyr Pro Leu Asn Ile Gln 
            420                 425                 430         


Asp Lys Ser Ala Thr Ala Ser Ala Pro Tyr Lys Phe Asp Ala Phe Thr 
        435                 440                 445             


Arg Pro Gly Ser Val Pro Cys Gln Ala Asp Ala Arg Cys Pro Gln Ser 
    450                 455                 460                 


Cys Val Thr Gly Val Tyr Thr Asp Pro Tyr Pro Leu Ile Phe Ala Lys 
465                 470                 475                 480 


Asp His Ser Ile Arg Gly Val Tyr Gly Met Met Leu Asn Asp Val Thr 
                485                 490                 495     


Ala Arg Leu Asn Pro Ile Ala Ala Val Phe Ser Asn Ile Ser Arg Ser 
            500                 505                 510         


Gln Ile Thr Arg Val Ser Ser Ser Ser Thr Lys Ala Ala Tyr Thr Thr 
        515                 520                 525             


Ser Thr Cys Phe Lys Val Ile Lys Thr Asn Arg Ile Tyr Cys Met Ser 
    530                 535                 540                 


Ile Ala Glu Ile Ser Asn Thr Leu Phe Gly Glu Phe Arg Ile Val Pro 
545                 550                 555                 560 


Leu Leu Val Glu Ile Leu Ser Asn Gly Gly Asn Thr Ala Arg Ser Ala 
                565                 570                 575     


Gly Gly Thr Pro Val Lys Glu Ser Pro Lys Gly Trp Ser Asp Ala Ile 
            580                 585                 590         


Ala Glu Pro Leu Phe Cys Thr Pro Thr Asn Val Thr Arg Tyr Asn Ala 
        595                 600                 605             


Asp Ile Arg Arg Tyr Ala Tyr Ser Trp Pro 
    610                 615             


<210>  339
<211>  551
<212>  PRT
<213>  Avian orthoavulavirus 16

<400>  339

Met Ile Phe Thr Met Tyr His Val Thr Val Leu Leu Leu Leu Ser Leu 
1               5                   10                  15      


Leu Thr Leu Pro Leu Gly Ile Gln Leu Ala Arg Ala Ser Ile Asp Gly 
            20                  25                  30          


Arg Gln Leu Ala Ala Ala Gly Ile Val Val Thr Gly Glu Lys Ala Ile 
        35                  40                  45              


Asn Leu Tyr Thr Ser Ser Gln Thr Gly Thr Ile Val Val Lys Leu Leu 
    50                  55                  60                  


Pro Asn Val Pro Gln Gly Arg Glu Ala Cys Met Arg Asp Pro Leu Thr 
65                  70                  75                  80  


Ser Tyr Asn Lys Thr Leu Thr Ser Leu Leu Ser Pro Leu Gly Glu Ala 
                85                  90                  95      


Ile Arg Arg Ile His Glu Ser Thr Thr Glu Thr Ala Gly Leu Val Gln 
            100                 105                 110         


Ala Arg Leu Val Gly Ala Ile Ile Gly Ser Val Ala Leu Gly Val Ala 
        115                 120                 125             


Thr Ser Ala Gln Ile Thr Ala Ala Ala Ala Leu Ile Gln Ala Asn Lys 
    130                 135                 140                 


Asn Ala Glu Asn Ile Leu Lys Leu Lys Gln Ser Ile Ala Ala Thr Asn 
145                 150                 155                 160 


Glu Ala Val His Glu Val Thr Asp Gly Leu Ser Gln Leu Ala Val Ala 
                165                 170                 175     


Val Gly Lys Met Gln Asp Phe Ile Asn Thr Gln Phe Asn Asn Thr Ala 
            180                 185                 190         


Gln Glu Ile Asp Cys Ile Arg Ile Ser Gln Gln Leu Gly Val Glu Leu 
        195                 200                 205             


Asn Leu Tyr Leu Thr Glu Leu Thr Thr Val Phe Gly Pro Gln Ile Thr 
    210                 215                 220                 


Ser Pro Ala Leu Ser Pro Leu Ser Ile Gln Ala Leu Tyr Asn Leu Ala 
225                 230                 235                 240 


Gly Gly Asn Leu Asp Val Leu Leu Ser Lys Ile Gly Val Gly Asn Asn 
                245                 250                 255     


Gln Leu Ser Ala Leu Ile Ser Ser Gly Leu Ile Ser Gly Ser Pro Ile 
            260                 265                 270         


Leu Tyr Asp Ser Gln Thr Gln Leu Leu Gly Ile Gln Val Thr Leu Pro 
        275                 280                 285             


Ser Val Ser Ser Leu Asn Asn Met Arg Ala Ile Phe Leu Glu Thr Leu 
    290                 295                 300                 


Ser Val Ser Thr Asp Lys Gly Phe Ala Ala Ala Leu Ile Pro Lys Val 
305                 310                 315                 320 


Val Thr Thr Val Gly Thr Val Thr Glu Glu Leu Asp Thr Ser Tyr Cys 
                325                 330                 335     


Ile Glu Thr Asp Ile Asp Leu Phe Cys Thr Arg Ile Val Thr Phe Pro 
            340                 345                 350         


Met Ser Pro Gly Ile Tyr Ala Cys Leu Asn Gly Asn Thr Ser Glu Cys 
        355                 360                 365             


Met Tyr Ser Lys Thr Gln Gly Ala Leu Thr Thr Pro Tyr Met Ser Val 
    370                 375                 380                 


Lys Gly Ser Ile Val Ala Asn Cys Lys Met Thr Thr Cys Arg Cys Ala 
385                 390                 395                 400 


Asp Pro Ala Ser Ile Ile Ser Gln Asn Tyr Gly Glu Ala Val Ser Leu 
                405                 410                 415     


Ile Asp Ser Ser Val Cys Arg Val Ile Thr Leu Asp Gly Val Thr Leu 
            420                 425                 430         


Arg Leu Ser Gly Ser Phe Asp Ser Thr Tyr Gln Lys Asn Ile Thr Ile 
        435                 440                 445             


Arg Asp Ser Gln Val Ile Ile Thr Gly Ser Leu Asp Ile Ser Thr Glu 
    450                 455                 460                 


Leu Gly Asn Val Asn Asn Ser Ile Asn Asn Ala Leu Asp Lys Ile Glu 
465                 470                 475                 480 


Glu Ser Asn Gln Ile Leu Glu Ser Val Asn Val Ser Leu Thr Ser Thr 
                485                 490                 495     


Asn Ala Leu Ile Val Tyr Ile Ile Cys Thr Ala Leu Ala Leu Ile Cys 
            500                 505                 510         


Gly Ile Thr Gly Leu Ile Leu Ser Cys Tyr Ile Met Tyr Lys Met Arg 
        515                 520                 525             


Ser Gln Gln Lys Thr Leu Met Trp Leu Gly Asn Asn Thr Leu Asp Gln 
    530                 535                 540                 


Met Arg Ala Gln Thr Lys Met 
545                 550     


<210>  340
<211>  541
<212>  PRT
<213>  Avian orthoavulavirus 17

<400>  340

Met Gln Leu Tyr Ser Val Leu Ala Leu Ala Leu Leu Ala Val Gln Ala 
1               5                   10                  15      


Gly Leu Gly Ile Ile Pro Ser Leu Ser Asn Thr Asn Ser Ile Asp Ala 
            20                  25                  30          


Gly Phe Val Phe Gln Ser Glu Arg Ala Val Asn Ile Tyr Thr Asn Ser 
        35                  40                  45              


Leu Thr Gly Ser Val Val Val Lys Leu Leu Pro Asn Leu Pro Asp His 
    50                  55                  60                  


Leu Lys Ser Cys His Leu Asp Val Leu Ser Ser Tyr Asn Arg Thr Leu 
65                  70                  75                  80  


Thr Ser Ile Phe Gln Pro Leu Gly Glu Ser Ile Lys His Ile Trp Gly 
                85                  90                  95      


Asn Thr Thr Gly Gly Ser Ala Ala Gly Gly Ile Gln Ser Arg Ile Val 
            100                 105                 110         


Gly Ala Ile Leu Gly Gly Val Ala Leu Gly Val Ala Thr Ser Ala Gln 
        115                 120                 125             


Ile Thr Ala Gly Val Ala Leu Ala Gln Ser Arg Gln Asn Ala Glu Asn 
    130                 135                 140                 


Ile Leu Lys Leu Lys Gln Ser Ile Ala Ala Thr Asn Asp Ala Val Gln 
145                 150                 155                 160 


Glu Val Ile Ala Gly Gln Arg Glu Leu Val Ile Ala Ile Gly Lys Met 
                165                 170                 175     


Gln Asp Tyr Ile Asn Gln Ala Leu Asn Ser Thr Ile Gln Gln Ile Asp 
            180                 185                 190         


Cys Val Thr Ala Ala Asn Arg Leu Gly Val Glu Leu Ser Leu Tyr Leu 
        195                 200                 205             


Thr Gln Leu Thr Thr Ala Phe Ser Asn Gln Ile Gln Asn Pro Ala Leu 
    210                 215                 220                 


Thr Pro Leu Ser Ile Gln Ala Leu Tyr Asn Leu Ala Gly Gly Asn Leu 
225                 230                 235                 240 


Asp Arg Phe Leu Asn Arg Ile Gly Ala Thr Thr Ser Asn Leu Gln Ser 
                245                 250                 255     


Ile Ile Ser Ser Gly Leu Ile Gln Gly Gln Pro Ile Gly Tyr Asp Ser 
            260                 265                 270         


Glu Lys Gln Leu Leu Ile Leu Ser Val Ser Val Pro Ser Ile Asn Ala 
        275                 280                 285             


Val Asp Asn Leu Arg Met Ala Gln Leu Thr Pro Ile Val Val Ser Thr 
    290                 295                 300                 


Ser Gln Gly Leu Gly Ala Val Val Ile Pro Lys Tyr Ile Ile Ala Ile 
305                 310                 315                 320 


Ala Asp Leu Ile Glu Glu Phe Val Ala Asp Asp Cys Ile Phe Thr Thr 
                325                 330                 335     


Ser Asp Ala Tyr Cys Thr Ser Leu Thr Thr Leu Pro Leu Ser Asn Ser 
            340                 345                 350         


Leu Gln Gln Cys Ile Arg Gly Asn Val Ser Ala Cys Ser Tyr Ser Leu 
        355                 360                 365             


Val Arg Gly Val Leu Ser Thr Lys Phe Ile Thr Leu Asp Gly Ser Val 
    370                 375                 380                 


Val Ala Asn Cys Gln Ala Val Thr Cys Arg Cys Ile Asp Pro Pro Lys 
385                 390                 395                 400 


Ile Ile Ser Gln Phe Ala Gly Lys Pro Leu Thr Ile Ile Asn Ser Lys 
                405                 410                 415     


Ile Cys Asn Val Ile Asn Ile Glu Gln Val Thr Leu Arg Leu Ser Gly 
            420                 425                 430         


His Phe Met Ser Gln Tyr Gly Ala Asn Leu Ser Ile Ser Glu Gly Gln 
        435                 440                 445             


Ile Val Val Thr Gly Pro Leu Asp Ile Ser Asn Glu Leu Gly Arg Val 
    450                 455                 460                 


Asn Gln Ser Ile Thr Asn Ala Gln Ala Ser Ile Asn Lys Ser Asn Gln 
465                 470                 475                 480 


Ile Leu Glu Gly Val Asn Val Arg Leu Ile Gln Val Pro Ala Leu Ala 
                485                 490                 495     


Thr Ser Leu Ala Leu Ala Ile Ala Gly Thr Val Leu Gly Ala Leu Ala 
            500                 505                 510         


Ile Ile Gly Ile Leu Val Leu Trp Val Thr Asn Lys Lys Gln Ser Lys 
        515                 520                 525             


Lys Ile Glu Trp Leu Leu Ala Ser Lys Ala Ser Lys Met 
    530                 535                 540     


<210>  341
<211>  599
<212>  PRT
<213>  Avian orthoavulavirus 17

<400>  341

Met Leu Arg Ala Glu Glu Leu Pro Phe His Leu Asp Gln Val Ser His 
1               5                   10                  15      


Ser Tyr Thr Thr Ile Ser Ala Met Pro Ser Ile Met Thr Ser Ala Ser 
            20                  25                  30          


Ser Gln Ser Arg Glu His Leu Ala Ser Arg Asp Asp Asp Asp Asp Ser 
        35                  40                  45              


Lys Cys Thr Trp Arg Leu Val Phe Arg Val Ser Ala Ile Ala Leu Leu 
    50                  55                  60                  


Leu Thr Ile Leu Gly Leu Ser Ile Ala Thr Phe Cys Lys Ile Pro Ser 
65                  70                  75                  80  


Lys Asp Phe Glu Pro Ile Ile Glu Glu Ala Val His Glu Ile Thr Ser 
                85                  90                  95      


Ile Leu Thr Pro Leu Gly Ala Gly Ile Thr Ala Ile Leu Asp Tyr Cys 
            100                 105                 110         


Gln Lys Ile Tyr Arg Gln Ser Val Leu Glu Thr Pro Leu Gln Leu Ser 
        115                 120                 125             


Ala Met Gln Thr Ser Ile Leu Gln Ser Leu Ser Ala Leu Ser Tyr Gln 
    130                 135                 140                 


Ile Ser Leu Glu Ala Asn Gly Ser Asn Cys Gly Ala Pro Ile His Asp 
145                 150                 155                 160 


Glu Ala Phe Ala Gly Gly Ile Glu Thr Pro Leu Phe Ser Gly Lys Phe 
                165                 170                 175     


Thr Asn Gly Lys Gln Phe Arg Val Ser Lys Tyr Ile Glu His Leu Asn 
            180                 185                 190         


Phe Ile Pro Ala Pro Thr Thr Gly Arg Gly Cys Thr Arg Ile Pro Ser 
        195                 200                 205             


Phe Ser Leu Ser Thr Ser His Gly Cys Tyr Thr His Asn Val Ile Leu 
    210                 215                 220                 


Asp Gly Cys Ala Asp His Gly Ala Ser His Gln Tyr Ile Ser Ile Gly 
225                 230                 235                 240 


Thr Leu Arg Val Ser Pro Ser Gly Arg Ile Tyr Phe Ser Thr Leu Arg 
                245                 250                 255     


Ser Val Asn Leu Asp Asp Gly Val Asn Arg Lys Ser Cys Ser Ile Ala 
            260                 265                 270         


Ala Thr Arg Tyr Gly Cys Asp Leu Leu Cys Ser Val Val Thr Glu Thr 
        275                 280                 285             


Glu Arg Ser Asp Tyr Ala Ser Asn Pro Pro Thr Arg Met Ile His Gly 
    290                 295                 300                 


Arg Leu Asp Phe Gly Gly Ser Tyr Ser Glu Thr Asp Ile Asn Ser Gln 
305                 310                 315                 320 


Val Ile Phe Ala Asp Trp Ala Ala Asn Tyr Pro Gly Val Gly Ser Gly 
                325                 330                 335     


Val Ala Val Asp Asp Arg Ile Leu Phe Pro Ile Tyr Gly Gly Leu Arg 
            340                 345                 350         


Ala Gly Thr Pro Ser Tyr Asn Lys Asn Tyr Gly Ser Tyr Ala Ile Tyr 
        355                 360                 365             


Gln Arg Ser Gly Asp Val Cys Pro Asp Asn Asn Ala Thr Gln Val Arg 
    370                 375                 380                 


Asn Ala Lys Ala Ser Tyr Ile Val Pro Leu Phe Ser Asn Arg Leu Ile 
385                 390                 395                 400 


Gln Gln Ala Ile Leu Ser Ile Arg Leu Asp Pro Gly Leu Gly Lys Asp 
                405                 410                 415     


Thr Thr Leu His Ile Ser Ser Asn Asn Val Thr Leu Met Gly Ala Glu 
            420                 425                 430         


Ala Arg Leu Val Ala Ile Asp Gly Gln Val Tyr Met Tyr Gln Arg Gly 
        435                 440                 445             


Ser Ser Trp Phe Pro Ala Ala Val Leu Tyr Pro Ile His Arg Lys Asn 
    450                 455                 460                 


Gly Thr Phe Thr Phe Gly Arg Pro Tyr Ile Tyr Asp Asn Phe Thr Arg 
465                 470                 475                 480 


Pro Gly Thr Gly Phe Cys Ser Ala Ala Ser Arg Cys Pro Asn Thr Cys 
                485                 490                 495     


Ile Thr Gly Val Tyr Thr Asp Ala Tyr Pro Ile Ile Phe Ser Ala Asp 
            500                 505                 510         


Lys Lys Pro Ile Gly Val Phe Gly Thr Tyr Leu Asn His Arg Ser Asp 
        515                 520                 525             


Arg Gln Asn Pro Arg Ser Ala Val Phe Phe Asp Val Thr Met Ser Asn 
    530                 535                 540                 


Ala Thr Asn Val Ser Thr Pro Pro Val Gly Ala Ala Tyr Thr Thr Ser 
545                 550                 555                 560 


Thr Cys Phe Lys Met Thr Ser Thr Gly Arg Arg Tyr Cys Ile Ser Ile 
                565                 570                 575     


Ala Glu Ile Arg Asn Thr Ile Phe Gly Glu Tyr Arg Ile Val Pro Leu 
            580                 585                 590         


Leu Val Glu Ile Glu Gln Val 
        595                 


<210>  342
<211>  577
<212>  PRT
<213>  Avian paraavulavirus 3

<400>  342

Met Glu Pro Thr Gly Ser Lys Val Asp Ile Val Pro Ser Gln Gly Thr 
1               5                   10                  15      


Lys Arg Thr Cys Arg Thr Phe Tyr Arg Leu Leu Ile Leu Ile Leu Asn 
            20                  25                  30          


Leu Ile Ile Ile Ile Leu Thr Ile Ile Ser Ile Tyr Val Ser Ile Ser 
        35                  40                  45              


Thr Asp Gln His Lys Leu Cys Asn Asn Glu Ala Asp Ser Leu Leu His 
    50                  55                  60                  


Ser Ile Val Glu Pro Ile Thr Val Pro Leu Gly Thr Asp Ser Asp Val 
65                  70                  75                  80  


Glu Asp Glu Leu Arg Glu Ile Arg Arg Asp Thr Gly Ile Asn Ile Pro 
                85                  90                  95      


Ile Gln Ile Asp Asn Thr Glu Asn Ile Ile Leu Thr Thr Leu Ala Ser 
            100                 105                 110         


Ile Asn Ser Asn Ile Ala Arg Leu His Asn Ala Thr Asp Glu Ser Pro 
        115                 120                 125             


Thr Cys Leu Ser Pro Val Asn Asp Pro Arg Phe Ile Ala Gly Ile Asn 
    130                 135                 140                 


Lys Ile Thr Lys Gly Ser Met Ile Tyr Arg Asn Phe Ser Asn Leu Ile 
145                 150                 155                 160 


Glu His Val Asn Phe Ile Pro Ser Pro Thr Thr Leu Ser Gly Cys Thr 
                165                 170                 175     


Arg Ile Pro Ser Phe Ser Leu Ser Lys Thr His Trp Cys Tyr Ser His 
            180                 185                 190         


Asn Val Ile Ser Thr Gly Cys Gln Asp His Ala Ala Ser Ser Gln Tyr 
        195                 200                 205             


Ile Ser Ile Gly Ile Val Asp Thr Gly Leu Asn Asn Glu Pro Tyr Leu 
    210                 215                 220                 


Arg Thr Met Ser Ser Arg Leu Leu Asn Asp Gly Leu Asn Arg Lys Ser 
225                 230                 235                 240 


Cys Ser Val Thr Ala Gly Ala Gly Val Cys Trp Leu Leu Cys Ser Val 
                245                 250                 255     


Val Thr Glu Ser Glu Ser Ala Asp Tyr Arg Ser Arg Ala Pro Thr Ala 
            260                 265                 270         


Met Ile Leu Gly Arg Phe Asn Phe Tyr Gly Asp Tyr Thr Glu Ser Pro 
        275                 280                 285             


Val Pro Ala Ser Leu Phe Ser Gly Arg Phe Thr Ala Asn Tyr Pro Gly 
    290                 295                 300                 


Val Gly Ser Gly Thr Gln Leu Asn Gly Thr Leu Tyr Phe Pro Ile Tyr 
305                 310                 315                 320 


Gly Gly Val Val Asn Asp Ser Asp Ile Glu Leu Ser Asn Arg Gly Lys 
                325                 330                 335     


Ser Phe Arg Pro Arg Asn Pro Thr Asn Pro Cys Pro Asp Pro Glu Val 
            340                 345                 350         


Thr Gln Ser Gln Arg Ala Gln Ala Ser Tyr Tyr Pro Thr Arg Phe Gly 
        355                 360                 365             


Arg Leu Leu Ile Gln Gln Ala Ile Leu Ala Cys Arg Ile Ser Asp Thr 
    370                 375                 380                 


Thr Cys Thr Asp Tyr Tyr Leu Leu Tyr Phe Asp Asn Asn Gln Val Met 
385                 390                 395                 400 


Met Gly Ala Glu Ala Arg Ile Tyr Tyr Leu Asn Asn Gln Met Tyr Leu 
                405                 410                 415     


Tyr Gln Arg Ser Ser Ser Trp Trp Pro His Pro Leu Phe Tyr Arg Phe 
            420                 425                 430         


Ser Leu Pro His Cys Glu Pro Met Ser Val Cys Met Ile Thr Asp Thr 
        435                 440                 445             


His Leu Ile Leu Thr Tyr Ala Thr Ser Arg Pro Gly Thr Ser Ile Cys 
    450                 455                 460                 


Thr Gly Ala Ser Arg Cys Pro Asn Asn Cys Val Asp Gly Val Tyr Thr 
465                 470                 475                 480 


Asp Val Trp Pro Leu Thr Glu Gly Thr Thr Gln Asp Pro Asp Ser Tyr 
                485                 490                 495     


Tyr Thr Val Phe Leu Asn Ser Pro Asn Arg Arg Ile Ser Pro Thr Ile 
            500                 505                 510         


Ser Ile Tyr Ser Tyr Asn Gln Lys Ile Ser Ser Arg Leu Ala Val Gly 
        515                 520                 525             


Ser Glu Ile Gly Ala Ala Tyr Thr Thr Ser Thr Cys Phe Ser Arg Thr 
    530                 535                 540                 


Asp Thr Gly Ala Leu Tyr Cys Ile Thr Ile Ile Glu Ala Val Asn Thr 
545                 550                 555                 560 


Ile Phe Gly Gln Tyr Arg Ile Val Pro Ile Leu Val Gln Leu Ile Ser 
                565                 570                 575     


Asp 
    


<210>  343
<211>  543
<212>  PRT
<213>  Avian paraavulavirus 3

<400>  343

Met Gln Pro Gly Ser Ala Leu His Leu Pro His Leu Tyr Ile Ile Ile 
1               5                   10                  15      


Ala Leu Val Ser Asp Gly Thr Leu Gly Gln Thr Ala Lys Ile Asp Arg 
            20                  25                  30          


Leu Ile Gln Ala Gly Ile Val Leu Gly Ser Gly Lys Glu Leu His Ile 
        35                  40                  45              


Ser Gln Asp Ser Gly Thr Leu Asp Leu Phe Val Arg Leu Leu Pro Val 
    50                  55                  60                  


Leu Pro Ser Asn Leu Ser His Cys Gln Leu Glu Ala Ile Thr Gln Tyr 
65                  70                  75                  80  


Asn Lys Thr Val Thr Arg Leu Leu Ala Pro Ile Gly Lys Asn Leu Glu 
                85                  90                  95      


Gln Val Leu Gln Ala Arg Pro Arg Gly Arg Leu Phe Gly Pro Ile Ile 
            100                 105                 110         


Gly Ser Ile Ala Leu Gly Val Ala Thr Ser Ala Gln Ile Thr Ala Ala 
        115                 120                 125             


Ile Ala Leu Val Arg Ala Gln Gln Asn Ala Asn Asp Ile Leu Ala Leu 
    130                 135                 140                 


Lys Asn Ala Leu Gln Ser Ser Asn Glu Ala Ile Arg Gln Leu Thr Tyr 
145                 150                 155                 160 


Gly Gln Asp Lys Gln Leu Leu Ala Ile Ser Lys Ile Gln Lys Ala Val 
                165                 170                 175     


Asn Glu Gln Ile Leu Pro Ala Leu Asp Gln Leu Asp Cys Ala Val Leu 
            180                 185                 190         


Gly Thr Lys Leu Ala Val Gln Leu Asn Leu Tyr Leu Ile Glu Met Thr 
        195                 200                 205             


Thr Ile Phe Gly Glu Gln Ile Asn Asn Pro Val Leu Ala Thr Ile Pro 
    210                 215                 220                 


Leu Ser Tyr Ile Leu Arg Leu Thr Gly Ala Glu Leu Asn Asn Val Leu 
225                 230                 235                 240 


Met Lys Gln Ala Arg Ser Ser Leu Ser Leu Val Gln Leu Val Ser Lys 
                245                 250                 255     


Gly Leu Leu Ser Gly Gln Val Ile Gly Tyr Asp Pro Ser Val Gln Gly 
            260                 265                 270         


Leu Ile Ile Arg Val Asn Leu Met Arg Thr Gln Lys Ile Asp Arg Ala 
        275                 280                 285             


Leu Val Tyr Gln Pro Tyr Val Leu Pro Ile Thr Leu Asn Ser Asn Ile 
    290                 295                 300                 


Val Thr Pro Ile Ala Pro Glu Cys Val Ile Gln Lys Gly Thr Ile Ile 
305                 310                 315                 320 


Glu Gly Met Ser Arg Lys Asp Cys Thr Glu Leu Glu Gln Asp Ile Ile 
                325                 330                 335     


Cys Arg Thr Val Thr Thr Tyr Thr Leu Ala Arg Asp Thr Arg Leu Cys 
            340                 345                 350         


Leu Gln Gly Asn Ile Ser Ser Cys Arg Tyr Gln Gln Ser Gly Thr Gln 
        355                 360                 365             


Leu His Thr Pro Phe Ile Thr Tyr Asn Gly Ala Val Ile Ala Asn Cys 
    370                 375                 380                 


Asp Leu Val Ser Cys Arg Cys Leu Arg Pro Pro Met Ile Ile Thr Gln 
385                 390                 395                 400 


Val Lys Gly Tyr Pro Leu Thr Ile Ile Thr Arg Ser Val Cys Gln Glu 
                405                 410                 415     


Leu Ser Val Asp Asn Leu Val Leu Asn Ile Glu Thr His His Asn Phe 
            420                 425                 430         


Ser Leu Asn Pro Thr Ile Ile Asp Pro Leu Thr Arg Val Ile Ala Thr 
        435                 440                 445             


Thr Pro Leu Glu Ile Asp Ser Leu Ile Gln Glu Ala Gln Asp His Ala 
    450                 455                 460                 


Asn Ala Ala Leu Ala Lys Val Glu Glu Ser Asp Lys Tyr Leu Arg Ala 
465                 470                 475                 480 


Val Thr Gly Gly Asn Tyr Ser Asn Trp Tyr Ile Val Leu Val Ile Val 
                485                 490                 495     


Leu Leu Phe Gly Asn Leu Gly Trp Ser Leu Leu Leu Thr Val Leu Leu 
            500                 505                 510         


Cys Arg Ser Arg Lys Gln Gln Arg Arg Tyr Gln Gln Asp Asp Ser Val 
        515                 520                 525             


Gly Ser Glu Arg Gly Val Gly Val Gly Thr Ile Gln Tyr Met Ser 
    530                 535                 540             


<210>  344
<211>  566
<212>  PRT
<213>  Avian paraavulavirus 4

<400>  344

Met Arg Leu Ser Arg Thr Ile Leu Thr Leu Ile Leu Gly Thr Leu Thr 
1               5                   10                  15      


Gly Tyr Leu Met Asp Ala His Ser Thr Thr Ala Asn Glu Arg Pro Lys 
            20                  25                  30          


Ser Glu Gly Ile Arg Gly Asp Leu Ile Pro Gly Ala Gly Ile Phe Val 
        35                  40                  45              


Thr Gln Val Arg Gln Leu Gln Ile Tyr Gln Gln Ser Gly Tyr His Asp 
    50                  55                  60                  


Leu Val Ile Arg Leu Leu Pro Leu Leu Pro Ala Glu Leu Asn Asp Cys 
65                  70                  75                  80  


Gln Arg Glu Val Val Thr Glu Tyr Asn Asn Thr Val Ser Gln Leu Leu 
                85                  90                  95      


Gln Pro Ile Lys Thr Asn Leu Asp Thr Leu Leu Ala Asp Gly Gly Thr 
            100                 105                 110         


Arg Asp Ala Asp Ile Gln Pro Arg Phe Ile Gly Ala Ile Ile Ala Thr 
        115                 120                 125             


Gly Ala Leu Ala Val Ala Thr Val Ala Glu Val Thr Ala Ala Gln Ala 
    130                 135                 140                 


Leu Ser Gln Ser Lys Thr Asn Ala Gln Asn Ile Leu Lys Leu Arg Asp 
145                 150                 155                 160 


Ser Ile Gln Ala Thr Asn Gln Ala Val Phe Glu Ile Ser Gln Gly Leu 
                165                 170                 175     


Asp Ala Thr Ala Thr Val Leu Ser Lys Leu Gln Thr Glu Leu Asn Glu 
            180                 185                 190         


Asn Ile Ile Pro Ser Leu Asn Asn Leu Ser Cys Ala Ala Met Gly Asn 
        195                 200                 205             


Arg Leu Gly Val Ser Leu Ser Leu Tyr Leu Thr Leu Met Thr Thr Leu 
    210                 215                 220                 


Phe Gly Asp Gln Ile Thr Asn Pro Val Leu Thr Pro Ile Ser Tyr Ser 
225                 230                 235                 240 


Thr Leu Ser Ala Met Ala Gly Gly His Ile Gly Pro Val Met Ser Lys 
                245                 250                 255     


Ile Leu Ala Gly Ser Val Thr Ser Gln Leu Gly Ala Glu Gln Leu Ile 
            260                 265                 270         


Ala Ser Gly Leu Ile Gln Ser Gln Val Val Gly Tyr Asp Ser Gln Tyr 
        275                 280                 285             


Gln Leu Leu Val Ile Arg Val Asn Leu Val Arg Ile Gln Glu Val Gln 
    290                 295                 300                 


Asn Thr Arg Val Val Ser Leu Arg Thr Leu Ala Val Asn Arg Asp Gly 
305                 310                 315                 320 


Gly Leu Tyr Arg Ala Gln Val Pro Pro Glu Val Val Glu Arg Ser Gly 
                325                 330                 335     


Ile Ala Glu Arg Phe Tyr Ala Asp Asp Cys Val Leu Thr Thr Thr Asp 
            340                 345                 350         


Tyr Ile Cys Ser Ser Ile Arg Ser Ser Arg Leu Asn Pro Glu Leu Val 
        355                 360                 365             


Lys Cys Leu Ser Gly Ala Leu Asp Ser Cys Thr Phe Glu Arg Glu Ser 
    370                 375                 380                 


Ala Leu Leu Ser Thr Pro Phe Phe Val Tyr Asn Lys Ala Val Val Ala 
385                 390                 395                 400 


Asn Cys Lys Ala Ala Thr Cys Arg Cys Asn Lys Pro Pro Ser Ile Ile 
                405                 410                 415     


Ala Gln Tyr Ser Ala Ser Ala Leu Val Thr Ile Thr Thr Asp Thr Cys 
            420                 425                 430         


Ala Asp Leu Glu Ile Glu Gly Tyr Arg Phe Asn Ile Gln Thr Glu Ser 
        435                 440                 445             


Asn Ser Trp Val Ala Pro Asn Phe Thr Val Ser Thr Ser Gln Ile Val 
    450                 455                 460                 


Ser Val Asp Pro Ile Asp Ile Ser Ser Asp Ile Ala Lys Ile Asn Ser 
465                 470                 475                 480 


Ser Ile Glu Ala Ala Arg Glu Gln Leu Glu Leu Ser Asn Gln Ile Leu 
                485                 490                 495     


Ser Arg Ile Asn Pro Arg Ile Val Asn Asp Glu Ser Leu Ile Ala Ile 
            500                 505                 510         


Ile Val Thr Ile Val Val Leu Ser Leu Leu Val Ile Gly Leu Ile Val 
        515                 520                 525             


Val Leu Gly Val Met Tyr Lys Asn Leu Lys Lys Val Gln Arg Ala Gln 
    530                 535                 540                 


Ala Ala Met Met Met Gln Gln Met Ser Ser Ser Gln Pro Val Thr Thr 
545                 550                 555                 560 


Lys Leu Gly Thr Pro Phe 
                565     


<210>  345
<211>  569
<212>  PRT
<213>  Avian paraavulavirus 4

<400>  345

Met Gln Gly Asp Met Glu Gly Ser Arg Asp Asn Leu Thr Val Asp Asp 
1               5                   10                  15      


Glu Leu Lys Thr Thr Trp Arg Leu Ala Tyr Arg Val Val Ser Leu Leu 
            20                  25                  30          


Leu Met Val Ser Ala Leu Ile Ile Ser Ile Val Ile Leu Thr Arg Asp 
        35                  40                  45              


Asn Ser Gln Ser Ile Ile Thr Ala Ile Asn Gln Ser Tyr Asp Ala Asp 
    50                  55                  60                  


Ser Lys Trp Gln Thr Gly Ile Glu Gly Lys Ile Thr Ser Ile Met Thr 
65                  70                  75                  80  


Asp Thr Leu Asp Thr Arg Asn Ala Ala Leu Leu His Ile Pro Leu Gln 
                85                  90                  95      


Leu Asn Thr Leu Glu Ala Asn Leu Leu Ser Ala Leu Gly Gly Tyr Thr 
            100                 105                 110         


Gly Ile Gly Pro Gly Asp Leu Glu His Cys Arg Tyr Pro Val His Asp 
        115                 120                 125             


Ser Ala Tyr Leu His Gly Val Asn Arg Leu Leu Ile Asn Gln Thr Ala 
    130                 135                 140                 


Asp Tyr Thr Ala Glu Gly Pro Leu Asp His Val Asn Phe Ile Pro Ala 
145                 150                 155                 160 


Pro Val Thr Thr Thr Gly Cys Thr Arg Ile Pro Ser Phe Ser Val Ser 
                165                 170                 175     


Ser Ser Ile Trp Cys Tyr Thr His Asn Val Ile Glu Thr Gly Cys Asn 
            180                 185                 190         


Asp His Ser Gly Ser Asn Gln Tyr Ile Ser Met Gly Val Ile Lys Arg 
        195                 200                 205             


Ala Gly Asn Gly Leu Pro Tyr Phe Ser Thr Val Val Ser Lys Tyr Leu 
    210                 215                 220                 


Thr Asp Gly Leu Asn Arg Lys Ser Cys Ser Val Ala Ala Gly Ser Gly 
225                 230                 235                 240 


His Cys Tyr Leu Leu Cys Ser Leu Val Ser Glu Pro Glu Pro Asp Asp 
                245                 250                 255     


Tyr Val Ser Pro Asp Pro Thr Pro Met Arg Leu Gly Val Leu Thr Arg 
            260                 265                 270         


Asp Gly Ser Tyr Thr Glu Gln Val Val Pro Glu Arg Ile Phe Lys Asn 
        275                 280                 285             


Ile Trp Ser Ala Asn Tyr Pro Gly Val Gly Ser Gly Ala Ile Ala Gly 
    290                 295                 300                 


Asn Lys Val Leu Phe Pro Phe Tyr Gly Gly Val Lys Asn Gly Ser Thr 
305                 310                 315                 320 


Pro Glu Val Met Asn Arg Gly Arg Tyr Tyr Tyr Ile Gln Asp Pro Asn 
                325                 330                 335     


Asp Tyr Cys Pro Asp Pro Leu Gln Asp Gln Ile Leu Arg Ala Glu Gln 
            340                 345                 350         


Ser Tyr Tyr Pro Thr Arg Phe Gly Arg Arg Met Val Met Gln Gly Val 
        355                 360                 365             


Leu Thr Cys Pro Val Ser Asn Asn Ser Thr Ile Ala Ser Gln Cys Gln 
    370                 375                 380                 


Ser Tyr Tyr Phe Asn Asn Ser Leu Gly Phe Ile Gly Ala Glu Ser Arg 
385                 390                 395                 400 


Ile Tyr Tyr Leu Asn Gly Asn Ile Tyr Leu Tyr Gln Arg Ser Ser Ser 
                405                 410                 415     


Trp Trp Pro His Pro Gln Ile Tyr Leu Leu Asp Ser Arg Ile Ala Ser 
            420                 425                 430         


Pro Gly Thr Gln Asn Ile Asp Ser Gly Val Asn Leu Lys Met Leu Asn 
        435                 440                 445             


Val Thr Val Ile Thr Arg Pro Ser Ser Gly Phe Cys Asn Ser Gln Ser 
    450                 455                 460                 


Arg Cys Pro Asn Asp Cys Leu Phe Gly Val Tyr Ser Asp Val Trp Pro 
465                 470                 475                 480 


Leu Ser Leu Thr Ser Asp Ser Ile Phe Ala Phe Thr Met Tyr Leu Gln 
                485                 490                 495     


Gly Lys Thr Thr Arg Ile Asp Pro Ala Trp Ala Leu Phe Ser Asn His 
            500                 505                 510         


Val Ile Gly His Glu Ala Arg Leu Phe Asn Lys Glu Val Ser Ala Ala 
        515                 520                 525             


Tyr Ser Thr Thr Thr Cys Phe Ser Asp Thr Ile Gln Asn Gln Val Tyr 
    530                 535                 540                 


Cys Leu Ser Ile Leu Glu Val Arg Ser Glu Leu Leu Gly Ala Phe Lys 
545                 550                 555                 560 


Ile Val Pro Phe Leu Tyr Arg Val Leu 
                565                 


<210>  346
<211>  621
<212>  PRT
<213>  Synodus synodonvirus

<400>  346

Met Lys Arg Val Leu Asp Trp Val His Gln Lys Met Ala Arg Lys Gly 
1               5                   10                  15      


Leu Asp Pro Ile Asn Pro Thr Ile Lys Val Gly Arg Asp Gly Thr Glu 
            20                  25                  30          


Val Asp Gln Gly Leu Ala Ile Tyr Ile Ala Arg Val Thr Val Ser Ile 
        35                  40                  45              


Leu Ala Ile Ile Leu Leu Thr Val Leu Leu Val Thr Pro Thr Val Thr 
    50                  55                  60                  


Gly Leu Phe Gln Val Phe Asp Ser Ser Ala Ser Glu Gln Ser His Pro 
65                  70                  75                  80  


Ile Met Asp Leu Leu Asn Asp Glu Val Leu Pro Pro Leu Arg Asn Thr 
                85                  90                  95      


His Ala Leu Leu Glu Glu Asp Thr Ala Pro Arg Val Arg Ser Ile Gln 
            100                 105                 110         


Thr Ala Val Glu Leu Arg Ile Pro Gly Asp Leu Lys Ser Ala Thr Gln 
        115                 120                 125             


Gln Ile Leu His Ala Ile Lys Asp Thr Cys Val Gly Gly Asp Gly Gly 
    130                 135                 140                 


Gly Thr Gly Pro Ala Pro Ser Cys Pro Pro Glu Gly Val Leu Pro Gln 
145                 150                 155                 160 


His His Ser Ala Phe Lys Pro Ile Asp Pro Asp Ser Phe Thr Pro Cys 
                165                 170                 175     


Ala Thr Gly Lys Pro Thr Phe Ser Gly Ser Pro Ala Ala Ser Ser Ser 
            180                 185                 190         


Ile Gly Ser Phe Pro Trp Ile Ser Ser Gly Thr Gln Asp Thr Pro Lys 
        195                 200                 205             


Ile Ser Met Thr Met Ser Ser Ser Tyr Leu Gly Phe Tyr Ala Thr Asp 
    210                 215                 220                 


Thr Tyr Ile Thr Thr Gly Gln Asn Lys Arg Ser Val Ser Val Ile Gly 
225                 230                 235                 240 


Leu Gly Arg Leu Thr Val Thr Glu Asp Gly Arg Ser Ser Ala Val Val 
                245                 250                 255     


Thr Glu Ala Glu Pro Ile His His Ser Ser Leu Ile Gly Tyr Gln Ser 
            260                 265                 270         


Thr Gly Thr Gly Ile Thr Gly Thr Val Ser Phe Phe Arg Thr Thr Gly 
        275                 280                 285             


Ser Glu Asp Thr Ala Asp Ala Gln Asp Val Gly Ile Arg Ser His Thr 
    290                 295                 300                 


Leu Leu Val Met Arg Arg Asn Arg Lys Leu Asp Thr Tyr Val Tyr Glu 
305                 310                 315                 320 


Gly Gly Glu Ile Gln Gly Gly Asp Met Tyr Met Met Ala Ser Pro Leu 
                325                 330                 335     


Ser Gly Gln Gly Thr Met Val Gly Asp Glu Met Val Leu Leu Gly Tyr 
            340                 345                 350         


Ala Val Pro Val Thr Asn Tyr Ala Gly Pro Val Trp Cys Pro Asn Thr 
        355                 360                 365             


Phe Cys Asn Thr Gln Thr Met Glu Ala Cys Lys Asn Ala Ser Gly Thr 
    370                 375                 380                 


Ile Arg Phe Pro Gly Ser Ser Thr Gly Leu Ala Val Val Met Val Arg 
385                 390                 395                 400 


Tyr Met Ile Gln Asp Leu Asp Lys Asp Gly Phe Lys Pro Lys Ile Thr 
                405                 410                 415     


Ile His Met Leu Asn Arg Glu Gln Trp Pro Ile Pro Gly Pro Tyr His 
            420                 425                 430         


Leu Thr Ser Gly Thr Lys Gly Leu Phe Ile Ser Val Tyr Ser Trp Gly 
        435                 440                 445             


Trp Tyr Gly His Pro Val Ser Gly Glu Ile Asn Arg Ala Thr Trp Asp 
    450                 455                 460                 


Met Arg Ser Ile Arg Leu Val Tyr Ala Leu Leu Trp Pro Asp Leu Pro 
465                 470                 475                 480 


Glu Thr Glu Gly Lys Cys Tyr Thr Asn Leu Ala Asn Pro Cys Pro Arg 
                485                 490                 495     


Ala Cys Thr Ile Gly Ser Thr Arg Ile Gly Ser Gly Ile Pro Leu Thr 
            500                 505                 510         


Phe Thr Gly Gln Leu Ser Ala Trp Leu Thr Ile Ser Ala Asp Gly Gly 
        515                 520                 525             


Ala Thr Arg Leu Lys Pro Glu Val Ala Val Ser Tyr Ser Asp Pro Ser 
    530                 535                 540                 


Tyr His Asp Leu Val Glu Arg Thr Tyr Pro Tyr Thr Thr Ala Ala Thr 
545                 550                 555                 560 


Phe Thr Ala Val Glu Gly Ser Ile Thr Cys Phe Met Val Ser Gly Leu 
                565                 570                 575     


Pro Gln Cys Ile Thr Leu Ile Glu Gly Asp Ser Ser Ala Tyr Ala Thr 
            580                 585                 590         


Asn Leu Gln Thr Tyr Asn Leu Trp Ser Leu Pro Ile Asp Cys Pro Ser 
        595                 600                 605             


Thr Arg Asn Leu Thr Leu Thr Thr Asn Thr Thr Ser Pro 
    610                 615                 620     


<210>  347
<211>  546
<212>  PRT
<213>  Synodus synodonvirus

<400>  347

Met Trp Pro Ile Leu Phe Leu Cys Val Gly Leu Met Ser Cys Val Ala 
1               5                   10                  15      


Gln Ser Ala Leu Leu Asp Gln Ser Lys Val Ala Pro Val Gly Val Phe 
            20                  25                  30          


Phe Thr Asp Pro Tyr Lys Leu Lys Ile Thr Gly Pro Glu Thr Thr Lys 
        35                  40                  45              


Leu Met Val Ile Arg Leu Ile Pro Ser Leu Gly Ala Ala Gln Thr Cys 
    50                  55                  60                  


Thr Gln Pro Ser Ile Asp Glu Tyr Lys Leu Leu Met Thr Ser Val Ile 
65                  70                  75                  80  


Thr Pro Ile Gln Ala Val Leu Ala Arg Thr Met Ala Ala Val Asp Val 
                85                  90                  95      


Thr Glu Gln Asn Thr Thr Ser Arg Ile Ala Gly Val Ile Val Gly Ser 
            100                 105                 110         


Val Ala Leu Gly Val Ala Thr Ser Ala Gln Ile Thr Ala Gly Ile Ala 
        115                 120                 125             


Leu His Asn Ser Gln Glu Asn Ala Lys Ala Ile Ala Ala Met Gly Asn 
    130                 135                 140                 


Ala Ile Thr Ala Thr Asn Thr Ala Val Gln Asn Leu Ile Thr Ala Gln 
145                 150                 155                 160 


Gly Gln Thr Val Thr Val Ile Asn Thr Met Gln Asp Gln Val Asn Asn 
                165                 170                 175     


Asp Ile Ile Pro Ala Ile Asn Thr Leu Ala Cys Ser Ile Ser Gln Asn 
            180                 185                 190         


Arg Met Ser Ile Ile Leu Gly Gln Phe Phe Ser Phe Val Gln Val Ala 
        195                 200                 205             


Phe Gly Pro Val Ile Gln Ser Pro Ile Asn Ser Pro Ile Thr Val Gln 
    210                 215                 220                 


Ala Leu Asn Thr Leu Phe Gly Gly Asp Leu Ser Arg Phe Met Glu Ala 
225                 230                 235                 240 


Leu Gly Tyr Ser Pro Gly Asp Leu Ser Asp Val Leu Ala Thr Gly Ser 
                245                 250                 255     


Ala Thr Val Arg Val Ile Ala Val Asp Pro Val Leu Phe Thr Leu Thr 
            260                 265                 270         


Leu Glu Ala Ser Phe Pro Thr Ile Ile Asp Tyr Pro Gly Ser Ser Ile 
        275                 280                 285             


Ile Pro Ile Gln Ala Ile Thr Phe Ser Thr Asn Gly Ser Glu Trp Leu 
    290                 295                 300                 


Thr Gln Thr Pro Pro Trp Ile His Thr Lys Glu Thr Gln Val Ser Gly 
305                 310                 315                 320 


Phe Asp Pro Ser Met Cys Lys Leu Thr Asp Thr Ser Met Val Cys Pro 
                325                 330                 335     


Arg Asp Thr Thr Tyr Ser Leu Ser Asp Ser Val Leu Thr Cys Leu Ser 
            340                 345                 350         


Gly Val Thr Ser Thr Cys Pro Lys Ile Arg Val Leu Asn Gly Leu Ser 
        355                 360                 365             


Pro Arg Tyr Val Val Tyr Lys Gly Val Val Ile Ala Asn Cys Arg Ala 
    370                 375                 380                 


Thr Ser Cys Val Cys Thr Asp Thr Gly Arg Pro Ile Ala Pro Leu Ser 
385                 390                 395                 400 


Gly Thr Leu Leu Thr Glu Ile Asn Gln Glu Met Cys Ser Val Ile Gly 
                405                 410                 415     


Val Asp Gly Val Leu Ile Arg Ala Glu Gln Lys Leu Glu Gly Val Ser 
            420                 425                 430         


Trp Gly Val Ser Ile Ala Ala Leu Gly Pro Thr Ile Gln Leu Asp Pro 
        435                 440                 445             


Val Asp Ile Ser Ser Glu Met Gly Ala Ile Asn His Ser Ile Asn Ala 
    450                 455                 460                 


Ala Gln Lys Ala Leu Asp Glu Ser Lys Arg Ile Leu Gln His Ile Asn 
465                 470                 475                 480 


Pro Asp Ile Val Asn Thr Glu Ser Ala Ile Ala Thr Ile Val Leu Ala 
                485                 490                 495     


Val Leu Ser Leu Val Met Ile Phe Phe Gly Ala Val Ala Leu Ile Tyr 
            500                 505                 510         


Leu His Lys Lys Ile Asn Asn Leu Ala Gln Ala Gln Arg Ile Ala Ser 
        515                 520                 525             


Phe Gln Met Ser Pro Thr Leu Ala His Arg Asn Tyr Ala Pro Arg His 
    530                 535                 540                 


Arg Gly 
545     


<210>  348
<211>  576
<212>  PRT
<213>  Salmo aquaparamyxovirus

<400>  348

Met Pro Pro Ala Pro Ser Pro Val His Asp Pro Ser Ser Phe Tyr Gly 
1               5                   10                  15      


Ser Ser Leu Phe Asn Glu Asp Thr Ala Ser Arg Lys Gly Thr Ser Glu 
            20                  25                  30          


Glu Ile His Leu Leu Gly Ile Arg Trp Asn Thr Val Leu Ile Val Leu 
        35                  40                  45              


Gly Leu Ile Leu Ala Ile Ile Gly Ile Gly Ile Gly Ala Ser Ser Phe 
    50                  55                  60                  


Ser Ala Ser Gly Ile Thr Gly Asn Thr Thr Lys Glu Ile Arg Leu Ile 
65                  70                  75                  80  


Val Glu Glu Met Ser Tyr Gly Leu Val Arg Ile Ser Asp Ser Val Arg 
                85                  90                  95      


Gln Glu Ile Ser Pro Lys Val Thr Leu Leu Gln Asn Ala Val Leu Ser 
            100                 105                 110         


Ser Ile Pro Ala Leu Val Thr Thr Glu Thr Asn Thr Ile Ile Asn Ala 
        115                 120                 125             


Val Lys Asn His Cys Asn Ser Pro Pro Thr Pro Pro Pro Pro Thr Glu 
    130                 135                 140                 


Ala Pro Leu Lys Lys His Glu Thr Gly Met Ala Pro Leu Asp Pro Thr 
145                 150                 155                 160 


Thr Tyr Trp Thr Cys Thr Ser Gly Thr Pro Arg Phe Tyr Ser Ser Pro 
                165                 170                 175     


Asn Ala Thr Phe Ile Pro Gly Pro Ser Pro Leu Pro His Thr Ala Thr 
            180                 185                 190         


Pro Gly Gly Cys Val Arg Ile Pro Ser Met His Ile Gly Ser Glu Ile 
        195                 200                 205             


Tyr Ala Tyr Thr Ser Asn Leu Ile Ala Ser Gly Cys Gln Asp Ile Gly 
    210                 215                 220                 


Lys Ser Tyr Gln Asn Val Gln Ile Gly Val Leu Asp Arg Thr Pro Glu 
225                 230                 235                 240 


Gly Asn Pro Glu Met Ser Pro Met Leu Ser His Thr Phe Pro Ile Asn 
                245                 250                 255     


Asp Asn Arg Lys Ser Cys Ser Ile Val Thr Leu Lys Arg Ala Ala Tyr 
            260                 265                 270         


Ile Tyr Cys Ser Gln Pro Lys Val Thr Glu Phe Val Asp Tyr Gln Thr 
        275                 280                 285             


Pro Gly Ile Glu Pro Met Ser Leu Asp His Ile Asn Ala Asn Gly Thr 
    290                 295                 300                 


Thr Lys Thr Trp Ile Tyr Ser Pro Thr Glu Val Val Thr Asp Val Pro 
305                 310                 315                 320 


Tyr Ala Ser Met Tyr Pro Ser Val Gly Ser Gly Val Val Ile Asp Gly 
                325                 330                 335     


Lys Leu Val Phe Leu Val Tyr Gly Gly Leu Leu Asn Gly Ile Gln Val 
            340                 345                 350         


Pro Ala Met Cys Leu Ser Pro Glu Cys Pro Gly Ile Asp Gln Ala Ala 
        355                 360                 365             


Cys Asn Ala Ser Gln Tyr Asn Gln Tyr Leu Ser Gly Arg Gln Val Val 
    370                 375                 380                 


Asn Gly Ile Ala Thr Val Asp Leu Met Asn Gly Gln Lys Pro His Ile 
385                 390                 395                 400 


Ser Val Glu Thr Ile Ser Pro Ser Lys Asn Trp Phe Gly Ala Glu Gly 
                405                 410                 415     


Arg Leu Val Tyr Met Gly Gly Arg Leu Tyr Ile Tyr Ile Arg Ser Thr 
            420                 425                 430         


Gly Trp His Ser Pro Ile Gln Ile Gly Val Ile Tyr Thr Met Asn Pro 
        435                 440                 445             


Leu Ala Ile Thr Trp Val Thr Asn Thr Val Leu Ser Arg Pro Gly Ser 
    450                 455                 460                 


Ala Gly Cys Asp Trp Asn Asn Arg Cys Pro Lys Ala Cys Leu Ser Gly 
465                 470                 475                 480 


Val Tyr Thr Asp Ala Tyr Pro Ile Ser Pro Asp Tyr Asn His Leu Ala 
                485                 490                 495     


Thr Met Ile Leu His Ser Thr Ser Thr Arg Ser Asn Pro Val Met Val 
            500                 505                 510         


Tyr Ser Ser Pro Thr Asn Met Val Asn Tyr Ala Gln Leu Thr Thr Thr 
        515                 520                 525             


Ala Gln Ile Ala Gly Tyr Thr Thr Thr Ser Cys Phe Thr Asp Asn Glu 
    530                 535                 540                 


Val Gly Tyr Cys Ala Thr Ala Leu Glu Leu Thr Pro Gly Thr Leu Ser 
545                 550                 555                 560 


Ser Val Gln Pro Ile Leu Val Met Thr Lys Ile Pro Lys Glu Cys Val 
                565                 570                 575     


<210>  349
<211>  552
<212>  PRT
<213>  Salmo aquaparamyxovirus

<400>  349

Met Asp Gly Pro Lys Phe Arg Phe Val Leu Leu Ile Leu Leu Thr Ala 
1               5                   10                  15      


Pro Ala Arg Gly Gln Val Asp Tyr Asp Lys Leu Leu Lys Val Gly Ile 
            20                  25                  30          


Phe Glu Lys Gly Thr Ala Asn Leu Lys Ile Ser Val Ser Ser Gln Gln 
        35                  40                  45              


Arg Tyr Met Val Ile Lys Met Met Pro Asn Leu Gly Pro Met Asn Gln 
    50                  55                  60                  


Cys Gly Ile Lys Glu Val Asn Leu Tyr Lys Glu Ser Ile Leu Arg Leu 
65                  70                  75                  80  


Ile Thr Pro Ile Ser Thr Thr Leu Asn Tyr Ile Lys Ser Glu Ile Gln 
                85                  90                  95      


Val Glu Arg Glu Val Ala Leu Gln Pro Asn Gly Thr Ile Val Arg Phe 
            100                 105                 110         


Phe Gly Leu Ile Val Ala Ala Gly Ala Leu Thr Leu Ala Thr Ser Ala 
        115                 120                 125             


Gln Ile Thr Ala Gly Ile Ala Leu His Asn Ser Leu Glu Asn Ala Lys 
    130                 135                 140                 


Ala Ile Lys Gly Leu Thr Asp Ala Ile Lys Glu Ser Asn Leu Ala Ile 
145                 150                 155                 160 


Gln Lys Ile Gln Asp Ala Thr Ala Gly Thr Val Ile Ala Leu Asn Ala 
                165                 170                 175     


Leu Gln Asp Gln Val Asn Thr Asn Ile Ile Pro Ala Ile Asn Thr Leu 
            180                 185                 190         


Gly Cys Thr Ala Ala Gly Asn Thr Leu Gly Ile Ala Leu Thr Arg Tyr 
        195                 200                 205             


Tyr Ser Glu Leu Ile Met Ile Phe Gly Pro Ser Leu Gly Asn Pro Val 
    210                 215                 220                 


Glu Ala Pro Leu Thr Ile Gln Ala Leu Ala Gly Ala Phe Asn Gly Asp 
225                 230                 235                 240 


Leu His Gly Met Ile Arg Glu Tyr Gly Tyr Thr Pro Ser Asp Ile Glu 
                245                 250                 255     


Asp Ile Leu Arg Thr Asn Ser Val Thr Gly Arg Val Ile Asp Val Asp 
            260                 265                 270         


Leu Val Gly Met Asn Ile Val Leu Glu Ile Asn Leu Pro Thr Leu Tyr 
        275                 280                 285             


Thr Leu Arg Asp Thr Lys Ile Val Asn Leu Gly Lys Ile Thr Tyr Asn 
    290                 295                 300                 


Val Asp Gly Ser Glu Trp Gln Thr Leu Val Pro Glu Trp Leu Ala Ile 
305                 310                 315                 320 


Arg Asn Thr Leu Met Gly Gly Val Asp Leu Ser Arg Cys Val Val Ser 
                325                 330                 335     


Ser Arg Asp Leu Ile Cys Lys Gln Asp Pro Val Phe Ser Leu Asp Thr 
            340                 345                 350         


Ser Ile Ile Ser Cys Leu Asn Gly Asn Thr Glu Ser Cys Pro Arg Asn 
        355                 360                 365             


Arg Val Val Asn Ser Val Ala Pro Arg Tyr Ala Val Ile Arg Gly Asn 
    370                 375                 380                 


Ile Leu Ala Asn Cys Ile Ser Thr Thr Cys Leu Cys Gly Asp Pro Gly 
385                 390                 395                 400 


Val Pro Ile Ile Gln Lys Gly Asp Asn Thr Leu Thr Ala Met Ser Ile 
                405                 410                 415     


Asn Asp Cys Lys Leu Val Gly Val Asp Gly Tyr Val Phe Arg Pro Gly 
            420                 425                 430         


Pro Lys Ala Val Asn Val Thr Phe Asn Leu Pro His Leu Asn Leu Gly 
        435                 440                 445             


Pro Glu Val Asn Val Asn Pro Val Asp Ile Ser Gly Ala Leu Gly Lys 
    450                 455                 460                 


Val Glu Gln Asp Leu Ala Ser Ser Arg Asp His Leu Ala Lys Ser Glu 
465                 470                 475                 480 


Lys Ile Leu Ser Gly Ile Asn Pro Asn Ile Ile Asn Thr Glu Met Val 
                485                 490                 495     


Leu Val Ala Val Ile Leu Ser Leu Val Cys Ala Met Val Val Ile Gly 
            500                 505                 510         


Ile Val Cys Trp Leu Ser Ile Leu Thr Lys Trp Val Arg Ser Cys Arg 
        515                 520                 525             


Ala Asp Cys Arg Arg Pro Asn Lys Gly Pro Asp Leu Gly Pro Ile Met 
    530                 535                 540                 


Ser Ser Gln Asp Asn Leu Ser Phe 
545                 550         


<210>  350
<211>  564
<212>  PRT
<213>  Reptilian ferlavirus

<400>  350

Met Asp Pro Lys Ser Tyr Tyr Cys Asn Glu Asp Leu Arg Ser Asp Gly 
1               5                   10                  15      


Gly Glu Lys Ser Pro Gly Gly Asp Leu Tyr Lys Gly Ile Ile Leu Val 
            20                  25                  30          


Ser Thr Val Ile Ser Leu Ile Ile Ala Ile Ile Ser Leu Ala Phe Ile 
        35                  40                  45              


Ile Asp Asn Lys Ile Asn Ile Gln Ser Leu Asp Pro Leu Arg Gly Leu 
    50                  55                  60                  


Glu Asp Ser Tyr Leu Val Pro Ile Lys Asp Lys Ser Glu Ser Ile Ser 
65                  70                  75                  80  


Gln Asp Ile Gln Glu Gly Ile Phe Pro Arg Leu Asn Leu Ile Thr Ala 
                85                  90                  95      


Ala Thr Thr Thr Thr Ile Pro Arg Ser Ile Ala Ile Gln Thr Lys Asp 
            100                 105                 110         


Leu Ser Asp Leu Ile Met Asn Arg Cys Tyr Pro Ser Val Val Asn Asn 
        115                 120                 125             


Asp Thr Ser Cys Asp Val Leu Ala Gly Ala Ile His Ser Asn Leu Phe 
    130                 135                 140                 


Ser Gln Leu Asp Pro Ser Thr Tyr Trp Thr Cys Ser Ser Gly Thr Pro 
145                 150                 155                 160 


Thr Met Asn Gln Thr Val Lys Leu Leu Pro Asp Asn Ser Gln Ile Pro 
                165                 170                 175     


Gly Ser Thr Tyr Ser Thr Gly Cys Val Arg Ile Pro Thr Phe Ser Leu 
            180                 185                 190         


Gly Ser Met Ile Tyr Ser Tyr Ser His Asn Val Ile Tyr Glu Gly Cys 
        195                 200                 205             


Asn Asp His Ser Lys Ser Ser Gln Tyr Trp Gln Leu Gly Tyr Ile Ser 
    210                 215                 220                 


Thr Ser Lys Thr Gly Glu Pro Leu Gln Gln Val Ser Arg Thr Leu Thr 
225                 230                 235                 240 


Leu Asn Asn Gly Leu Asn Arg Lys Ser Cys Ser Thr Val Ala Gln Gly 
                245                 250                 255     


Arg Gly Ala Tyr Leu Leu Cys Thr Asn Val Val Glu Asp Glu Arg Thr 
            260                 265                 270         


Asp Tyr Ser Thr Glu Gly Ile Gln Asp Leu Thr Leu Asp Tyr Ile Asp 
        275                 280                 285             


Ile Phe Gly Ala Glu Arg Ser Tyr Arg Tyr Thr Asn Asn Glu Val Asp 
    290                 295                 300                 


Leu Asp Arg Pro Tyr Ala Ala Leu Tyr Pro Ser Val Gly Ser Gly Thr 
305                 310                 315                 320 


Val Tyr Asn Asp Arg Ile Leu Phe Leu Gly Tyr Gly Gly Leu Met Thr 
                325                 330                 335     


Pro Tyr Gly Asp Gln Ala Met Cys Gln Ala Pro Glu Cys Thr Ser Ala 
            340                 345                 350         


Thr Gln Glu Gly Cys Asn Ser Asn Gln Leu Ile Gly Tyr Phe Ser Gly 
        355                 360                 365             


Arg Gln Ile Val Asn Cys Ile Ile Glu Ile Ile Thr Val Gly Thr Glu 
    370                 375                 380                 


Lys Pro Ile Ile Arg Val Arg Thr Ile Pro Asn Ser Gln Val Trp Leu 
385                 390                 395                 400 


Gly Ala Glu Gly Arg Ile Gln Thr Leu Gly Gly Val Leu Tyr Leu Tyr 
                405                 410                 415     


Ile Arg Ser Ser Gly Trp His Ala Leu Ala Gln Thr Gly Ile Ile Leu 
            420                 425                 430         


Thr Leu Asp Pro Ile Arg Ile Ser Trp Ile Val Asn Thr Gly Tyr Ser 
        435                 440                 445             


Arg Pro Gly Asn Gly Pro Cys Ser Ala Ser Ser Arg Cys Pro Ala Gln 
    450                 455                 460                 


Cys Ile Thr Gly Val Tyr Thr Asp Ile Phe Pro Leu Ser Gln Asn Tyr 
465                 470                 475                 480 


Gly Tyr Leu Ala Thr Val Thr Leu Leu Ser Gly Val Asp Arg Val Asn 
                485                 490                 495     


Pro Val Ile Ser Tyr Gly Thr Ser Thr Gly Arg Val Ala Asp Ser Gln 
            500                 505                 510         


Leu Thr Ser Ser Ser Gln Val Ala Ala Tyr Thr Thr Thr Thr Cys Phe 
        515                 520                 525             


Thr Phe Asn Gln Lys Gly Tyr Cys Tyr His Ile Ile Glu Leu Ser Pro 
    530                 535                 540                 


Ala Thr Leu Gly Ile Phe Gln Pro Val Leu Val Val Thr Glu Ile Pro 
545                 550                 555                 560 


Lys Ile Cys Ser 
                


<210>  351
<211>  545
<212>  PRT
<213>  Reptilian ferlavirus

<400>  351

Met Thr Arg Ile Thr Ile Leu Gln Ile Ile Leu Thr Leu Thr Leu Pro 
1               5                   10                  15      


Val Met Cys Gln Val Ser Phe Asp Asn Leu Glu Gln Val Gly Val Met 
            20                  25                  30          


Phe Asp Lys Pro Lys Phe Leu Lys Ile Thr Gly Pro Ala Ser Thr Ala 
        35                  40                  45              


Thr Met Ile Ile Lys Leu Ile Pro Thr Leu Gly Thr Met Glu Ser Cys 
    50                  55                  60                  


Gly Thr Ser Ala Val Asn Glu Tyr Lys Lys Thr Leu Asp Thr Ile Leu 
65                  70                  75                  80  


Val Pro Leu Arg Asp Thr Ile Asn Lys Leu Ser Thr Asp Ile Thr Val 
                85                  90                  95      


Val Glu Gly Thr Ser Asn Ile Ser Asn Lys Arg Glu Lys Arg Phe Val 
            100                 105                 110         


Gly Ile Ala Ile Ala Val Gly Ala Val Ala Leu Ala Thr Ser Ala Gln 
        115                 120                 125             


Ile Thr Ala Gly Ile Ala Leu Ser Asn Thr Ile Lys Asn Ala Glu Ala 
    130                 135                 140                 


Ile Glu Ser Ile Lys Ser Ser Ile Gln Ala Ser Asn Gln Ala Ile Gln 
145                 150                 155                 160 


Lys Val Ile Asp Ala Gln Gly Arg Thr Val Thr Val Ile Asn Gly Ile 
                165                 170                 175     


Gln Asp His Ile Asn Ser Val Ile Asn Pro Ala Leu Asn Gln Leu Gly 
            180                 185                 190         


Cys Asp Val Ala Lys Asn Thr Leu Ala Ile Ser Leu Thr Gln Tyr Phe 
        195                 200                 205             


Ser Lys Leu Ser Leu Leu Phe Gly Pro Asn Leu Arg Asn Pro Val Glu 
    210                 215                 220                 


Gln Pro Leu Ser Val Gln Ala Ile Ala Gly Leu Met Asp Gly Asp Ile 
225                 230                 235                 240 


Asn Ala Val Val Ser Gln Leu Gly Tyr Thr Gln Ser Asp Leu Leu Asp 
                245                 250                 255     


Leu Leu Ser Thr Glu Ser Ile Val Gly Thr Val Thr Ala Ile Asp Met 
            260                 265                 270         


Val Asn Tyr Met Ile Gln Ile Glu Met Ser Phe Pro Gln Tyr Ile Thr 
        275                 280                 285             


Ile Pro Asp Thr Lys Val Leu Glu Gly His Lys Ile Thr Phe Asn Asp 
    290                 295                 300                 


Lys Gly Ser Glu Trp Gln Thr Gln Val Pro Ser Thr Ile Ala Val Arg 
305                 310                 315                 320 


Asp Ile Leu Ile Ala Gly Val Asp Pro Asp Gly Cys Ser Ile Thr Ser 
                325                 330                 335     


Thr Ser Tyr Ile Cys Lys Asn Asp Pro Thr Tyr Ala Met Ser Glu Val 
            340                 345                 350         


Leu Thr Asn Cys Phe Arg Gly Asn Thr Gln Glu Cys Pro Arg Ala Arg 
        355                 360                 365             


Ile Thr Ser Thr Phe Ala Thr Arg Phe Ala Ile Ala Arg Ser Thr Val 
    370                 375                 380                 


Ile Ala Asn Cys Val Ala Ala Val Cys Leu Cys Gly Asp Pro Gly Ile 
385                 390                 395                 400 


Pro Val Val Gln Lys Ala Glu Val Thr Leu Thr Ala Met Thr Leu Asp 
                405                 410                 415     


Gln Cys Ser Leu Ile Thr Val Asp Gly Leu Gln Ile Lys Pro Ser Lys 
            420                 425                 430         


Ser Ile Ala Asn Val Thr Ala Asn Phe Gly Asn Ile Thr Leu Gly Pro 
        435                 440                 445             


Val Val Ser Val Gly Asp Leu Asp Leu Ser Ala Glu Leu Thr Lys Val 
    450                 455                 460                 


Gln Ser Asp Leu Lys Glu Ala Gln Asp Lys Leu Asp Glu Ser Asn Ala 
465                 470                 475                 480 


Ile Leu Gln Gly Ile Asn Asn Lys Ile Leu Thr Ala Pro Thr Ser Ile 
                485                 490                 495     


Ala Leu Ile Val Val Ser Val Val Val Ile Leu Leu Ile Ile Gly Met 
            500                 505                 510         


Ile Ser Trp Leu Val Trp Leu Thr Lys Ala Val Arg Arg Ser Asn Thr 
        515                 520                 525             


Arg Ser Glu Arg Val Thr Pro Ser Ala Tyr Asn Asn Leu Gly Phe Ile 
    530                 535                 540                 


Lys 
545 


<210>  352
<211>  622
<212>  PRT
<213>  Cedar henipavirus

<400>  352

Met Leu Ser Gln Leu Gln Lys Asn Tyr Leu Asp Asn Ser Asn Gln Gln 
1               5                   10                  15      


Gly Asp Lys Met Asn Asn Pro Asp Lys Lys Leu Ser Val Asn Phe Asn 
            20                  25                  30          


Pro Leu Glu Leu Asp Lys Gly Gln Lys Asp Leu Asn Lys Ser Tyr Tyr 
        35                  40                  45              


Val Lys Asn Lys Asn Tyr Asn Val Ser Asn Leu Leu Asn Glu Ser Leu 
    50                  55                  60                  


His Asp Ile Lys Phe Cys Ile Tyr Cys Ile Phe Ser Leu Leu Ile Ile 
65                  70                  75                  80  


Ile Thr Ile Ile Asn Ile Ile Thr Ile Ser Ile Val Ile Thr Arg Leu 
                85                  90                  95      


Lys Val His Glu Glu Asn Asn Gly Met Glu Ser Pro Asn Leu Gln Ser 
            100                 105                 110         


Ile Gln Asp Ser Leu Ser Ser Leu Thr Asn Met Ile Asn Thr Glu Ile 
        115                 120                 125             


Thr Pro Arg Ile Gly Ile Leu Val Thr Ala Thr Ser Val Thr Leu Ser 
    130                 135                 140                 


Ser Ser Ile Asn Tyr Val Gly Thr Lys Thr Asn Gln Leu Val Asn Glu 
145                 150                 155                 160 


Leu Lys Asp Tyr Ile Thr Lys Ser Cys Gly Phe Lys Val Pro Glu Leu 
                165                 170                 175     


Lys Leu His Glu Cys Asn Ile Ser Cys Ala Asp Pro Lys Ile Ser Lys 
            180                 185                 190         


Ser Ala Met Tyr Ser Thr Asn Ala Tyr Ala Glu Leu Ala Gly Pro Pro 
        195                 200                 205             


Lys Ile Phe Cys Lys Ser Val Ser Lys Asp Pro Asp Phe Arg Leu Lys 
    210                 215                 220                 


Gln Ile Asp Tyr Val Ile Pro Val Gln Gln Asp Arg Ser Ile Cys Met 
225                 230                 235                 240 


Asn Asn Pro Leu Leu Asp Ile Ser Asp Gly Phe Phe Thr Tyr Ile His 
                245                 250                 255     


Tyr Glu Gly Ile Asn Ser Cys Lys Lys Ser Asp Ser Phe Lys Val Leu 
            260                 265                 270         


Leu Ser His Gly Glu Ile Val Asp Arg Gly Asp Tyr Arg Pro Ser Leu 
        275                 280                 285             


Tyr Leu Leu Ser Ser His Tyr His Pro Tyr Ser Met Gln Val Ile Asn 
    290                 295                 300                 


Cys Val Pro Val Thr Cys Asn Gln Ser Ser Phe Val Phe Cys His Ile 
305                 310                 315                 320 


Ser Asn Asn Thr Lys Thr Leu Asp Asn Ser Asp Tyr Ser Ser Asp Glu 
                325                 330                 335     


Tyr Tyr Ile Thr Tyr Phe Asn Gly Ile Asp Arg Pro Lys Thr Lys Lys 
            340                 345                 350         


Ile Pro Ile Asn Asn Met Thr Ala Asp Asn Arg Tyr Ile His Phe Thr 
        355                 360                 365             


Phe Ser Gly Gly Gly Gly Val Cys Leu Gly Glu Glu Phe Ile Ile Pro 
    370                 375                 380                 


Val Thr Thr Val Ile Asn Thr Asp Val Phe Thr His Asp Tyr Cys Glu 
385                 390                 395                 400 


Ser Phe Asn Cys Ser Val Gln Thr Gly Lys Ser Leu Lys Glu Ile Cys 
                405                 410                 415     


Ser Glu Ser Leu Arg Ser Pro Thr Asn Ser Ser Arg Tyr Asn Leu Asn 
            420                 425                 430         


Gly Ile Met Ile Ile Ser Gln Asn Asn Met Thr Asp Phe Lys Ile Gln 
        435                 440                 445             


Leu Asn Gly Ile Thr Tyr Asn Lys Leu Ser Phe Gly Ser Pro Gly Arg 
    450                 455                 460                 


Leu Ser Lys Thr Leu Gly Gln Val Leu Tyr Tyr Gln Ser Ser Met Ser 
465                 470                 475                 480 


Trp Asp Thr Tyr Leu Lys Ala Gly Phe Val Glu Lys Trp Lys Pro Phe 
                485                 490                 495     


Thr Pro Asn Trp Met Asn Asn Thr Val Ile Ser Arg Pro Asn Gln Gly 
            500                 505                 510         


Asn Cys Pro Arg Tyr His Lys Cys Pro Glu Ile Cys Tyr Gly Gly Thr 
        515                 520                 525             


Tyr Asn Asp Ile Ala Pro Leu Asp Leu Gly Lys Asp Met Tyr Val Ser 
    530                 535                 540                 


Val Ile Leu Asp Ser Asp Gln Leu Ala Glu Asn Pro Glu Ile Thr Val 
545                 550                 555                 560 


Phe Asn Ser Thr Thr Ile Leu Tyr Lys Glu Arg Val Ser Lys Asp Glu 
                565                 570                 575     


Leu Asn Thr Arg Ser Thr Thr Thr Ser Cys Phe Leu Phe Leu Asp Glu 
            580                 585                 590         


Pro Trp Cys Ile Ser Val Leu Glu Thr Asn Arg Phe Asn Gly Lys Ser 
        595                 600                 605             


Ile Arg Pro Glu Ile Tyr Ser Tyr Lys Ile Pro Lys Tyr Cys 
    610                 615                 620         


<210>  353
<211>  557
<212>  PRT
<213>  Cedar henipavirus

<400>  353

Met Ser Asn Lys Arg Thr Thr Val Leu Ile Ile Ile Ser Tyr Thr Leu 
1               5                   10                  15      


Phe Tyr Leu Asn Asn Ala Ala Ile Val Gly Phe Asp Phe Asp Lys Leu 
            20                  25                  30          


Asn Lys Ile Gly Val Val Gln Gly Arg Val Leu Asn Tyr Lys Ile Lys 
        35                  40                  45              


Gly Asp Pro Met Thr Lys Asp Leu Val Leu Lys Phe Ile Pro Asn Ile 
    50                  55                  60                  


Val Asn Ile Thr Glu Cys Val Arg Glu Pro Leu Ser Arg Tyr Asn Glu 
65                  70                  75                  80  


Thr Val Arg Arg Leu Leu Leu Pro Ile His Asn Met Leu Gly Leu Tyr 
                85                  90                  95      


Leu Asn Asn Thr Asn Ala Lys Met Thr Gly Leu Met Ile Ala Gly Val 
            100                 105                 110         


Ile Met Gly Gly Ile Ala Ile Gly Ile Ala Thr Ala Ala Gln Ile Thr 
        115                 120                 125             


Ala Gly Phe Ala Leu Tyr Glu Ala Lys Lys Asn Thr Glu Asn Ile Gln 
    130                 135                 140                 


Lys Leu Thr Asp Ser Ile Met Lys Thr Gln Asp Ser Ile Asp Lys Leu 
145                 150                 155                 160 


Thr Asp Ser Val Gly Thr Ser Ile Leu Ile Leu Asn Lys Leu Gln Thr 
                165                 170                 175     


Tyr Ile Asn Asn Gln Leu Val Pro Asn Leu Glu Leu Leu Ser Cys Arg 
            180                 185                 190         


Gln Asn Lys Ile Glu Phe Asp Leu Met Leu Thr Lys Tyr Leu Val Asp 
        195                 200                 205             


Leu Met Thr Val Ile Gly Pro Asn Ile Asn Asn Pro Val Asn Lys Asp 
    210                 215                 220                 


Met Thr Ile Gln Ser Leu Ser Leu Leu Phe Asp Gly Asn Tyr Asp Ile 
225                 230                 235                 240 


Met Met Ser Glu Leu Gly Tyr Thr Pro Gln Asp Phe Leu Asp Leu Ile 
                245                 250                 255     


Glu Ser Lys Ser Ile Thr Gly Gln Ile Ile Tyr Val Asp Met Glu Asn 
            260                 265                 270         


Leu Tyr Val Val Ile Arg Thr Tyr Leu Pro Thr Leu Ile Glu Val Pro 
        275                 280                 285             


Asp Ala Gln Ile Tyr Glu Phe Asn Lys Ile Thr Met Ser Ser Asn Gly 
    290                 295                 300                 


Gly Glu Tyr Leu Ser Thr Ile Pro Asn Phe Ile Leu Ile Arg Gly Asn 
305                 310                 315                 320 


Tyr Met Ser Asn Ile Asp Val Ala Thr Cys Tyr Met Thr Lys Ala Ser 
                325                 330                 335     


Val Ile Cys Asn Gln Asp Tyr Ser Leu Pro Met Ser Gln Asn Leu Arg 
            340                 345                 350         


Ser Cys Tyr Gln Gly Glu Thr Glu Tyr Cys Pro Val Glu Ala Val Ile 
        355                 360                 365             


Ala Ser His Ser Pro Arg Phe Ala Leu Thr Asn Gly Val Ile Phe Ala 
    370                 375                 380                 


Asn Cys Ile Asn Thr Ile Cys Arg Cys Gln Asp Asn Gly Lys Thr Ile 
385                 390                 395                 400 


Thr Gln Asn Ile Asn Gln Phe Val Ser Met Ile Asp Asn Ser Thr Cys 
                405                 410                 415     


Asn Asp Val Met Val Asp Lys Phe Thr Ile Lys Val Gly Lys Tyr Met 
            420                 425                 430         


Gly Arg Lys Asp Ile Asn Asn Ile Asn Ile Gln Ile Gly Pro Gln Ile 
        435                 440                 445             


Ile Ile Asp Lys Val Asp Leu Ser Asn Glu Ile Asn Lys Met Asn Gln 
    450                 455                 460                 


Ser Leu Lys Asp Ser Ile Phe Tyr Leu Arg Glu Ala Lys Arg Ile Leu 
465                 470                 475                 480 


Asp Ser Val Asn Ile Ser Leu Ile Ser Pro Ser Val Gln Leu Phe Leu 
                485                 490                 495     


Ile Ile Ile Ser Val Leu Ser Phe Ile Ile Leu Leu Ile Ile Ile Val 
            500                 505                 510         


Tyr Leu Tyr Cys Lys Ser Lys His Ser Tyr Lys Tyr Asn Lys Phe Ile 
        515                 520                 525             


Asp Asp Pro Asp Tyr Tyr Asn Asp Tyr Lys Arg Glu Arg Ile Asn Gly 
    530                 535                 540                 


Lys Ala Ser Lys Ser Asn Asn Ile Tyr Tyr Val Gly Asp 
545                 550                 555         


<210>  354
<211>  632
<212>  PRT
<213>  Ghanaian bat henipavirus

<400>  354

Met Pro Gln Lys Thr Val Glu Phe Ile Asn Met Asn Ser Pro Leu Glu 
1               5                   10                  15      


Arg Gly Val Ser Thr Leu Ser Asp Lys Lys Thr Leu Asn Gln Ser Lys 
            20                  25                  30          


Ile Thr Lys Gln Gly Tyr Phe Gly Leu Gly Ser His Ser Glu Arg Asn 
        35                  40                  45              


Trp Lys Lys Gln Lys Asn Gln Asn Asp His Tyr Met Thr Val Ser Thr 
    50                  55                  60                  


Met Ile Leu Glu Ile Leu Val Val Leu Gly Ile Met Phe Asn Leu Ile 
65                  70                  75                  80  


Val Leu Thr Met Val Tyr Tyr Gln Asn Asp Asn Ile Asn Gln Arg Met 
                85                  90                  95      


Ala Glu Leu Thr Ser Asn Ile Thr Val Leu Asn Leu Asn Leu Asn Gln 
            100                 105                 110         


Leu Thr Asn Lys Ile Gln Arg Glu Ile Ile Pro Arg Ile Thr Leu Ile 
        115                 120                 125             


Asp Thr Ala Thr Thr Ile Thr Ile Pro Ser Ala Ile Thr Tyr Ile Leu 
    130                 135                 140                 


Ala Thr Leu Thr Thr Arg Ile Ser Glu Leu Leu Pro Ser Ile Asn Gln 
145                 150                 155                 160 


Lys Cys Glu Phe Lys Thr Pro Thr Leu Val Leu Asn Asp Cys Arg Ile 
                165                 170                 175     


Asn Cys Thr Pro Pro Leu Asn Pro Ser Asp Gly Val Lys Met Ser Ser 
            180                 185                 190         


Leu Ala Thr Asn Leu Val Ala His Gly Pro Ser Pro Cys Arg Asn Phe 
        195                 200                 205             


Ser Ser Val Pro Thr Ile Tyr Tyr Tyr Arg Ile Pro Gly Leu Tyr Asn 
    210                 215                 220                 


Arg Thr Ala Leu Asp Glu Arg Cys Ile Leu Asn Pro Arg Leu Thr Ile 
225                 230                 235                 240 


Ser Ser Thr Lys Phe Ala Tyr Val His Ser Glu Tyr Asp Lys Asn Cys 
                245                 250                 255     


Thr Arg Gly Phe Lys Tyr Tyr Glu Leu Met Thr Phe Gly Glu Ile Leu 
            260                 265                 270         


Glu Gly Pro Glu Lys Glu Pro Arg Met Phe Ser Arg Ser Phe Tyr Ser 
        275                 280                 285             


Pro Thr Asn Ala Val Asn Tyr His Ser Cys Thr Pro Ile Val Thr Val 
    290                 295                 300                 


Asn Glu Gly Tyr Phe Leu Cys Leu Glu Cys Thr Ser Ser Asp Pro Leu 
305                 310                 315                 320 


Tyr Lys Ala Asn Leu Ser Asn Ser Thr Phe His Leu Val Ile Leu Arg 
                325                 330                 335     


His Asn Lys Asp Glu Lys Ile Val Ser Met Pro Ser Phe Asn Leu Ser 
            340                 345                 350         


Thr Asp Gln Glu Tyr Val Gln Ile Ile Pro Ala Glu Gly Gly Gly Thr 
        355                 360                 365             


Ala Glu Ser Gly Asn Leu Tyr Phe Pro Cys Ile Gly Arg Leu Leu His 
    370                 375                 380                 


Lys Arg Val Thr His Pro Leu Cys Lys Lys Ser Asn Cys Ser Arg Thr 
385                 390                 395                 400 


Asp Asp Glu Ser Cys Leu Lys Ser Tyr Tyr Asn Gln Gly Ser Pro Gln 
                405                 410                 415     


His Gln Val Val Asn Cys Leu Ile Arg Ile Arg Asn Ala Gln Arg Asp 
            420                 425                 430         


Asn Pro Thr Trp Asp Val Ile Thr Val Asp Leu Thr Asn Thr Tyr Pro 
        435                 440                 445             


Gly Ser Arg Ser Arg Ile Phe Gly Ser Phe Ser Lys Pro Met Leu Tyr 
    450                 455                 460                 


Gln Ser Ser Val Ser Trp His Thr Leu Leu Gln Val Ala Glu Ile Thr 
465                 470                 475                 480 


Asp Leu Asp Lys Tyr Gln Leu Asp Trp Leu Asp Thr Pro Tyr Ile Ser 
                485                 490                 495     


Arg Pro Gly Gly Ser Glu Cys Pro Phe Gly Asn Tyr Cys Pro Thr Val 
            500                 505                 510         


Cys Trp Glu Gly Thr Tyr Asn Asp Val Tyr Ser Leu Thr Pro Asn Asn 
        515                 520                 525             


Asp Leu Phe Val Thr Val Tyr Leu Lys Ser Glu Gln Val Ala Glu Asn 
    530                 535                 540                 


Pro Tyr Phe Ala Ile Phe Ser Arg Asp Gln Ile Leu Lys Glu Phe Pro 
545                 550                 555                 560 


Leu Asp Ala Trp Ile Ser Ser Ala Arg Thr Thr Thr Ile Ser Cys Phe 
                565                 570                 575     


Met Phe Asn Asn Glu Ile Trp Cys Ile Ala Ala Leu Glu Ile Thr Arg 
            580                 585                 590         


Leu Asn Asp Asp Ile Ile Arg Pro Ile Tyr Tyr Ser Phe Trp Leu Pro 
        595                 600                 605             


Thr Asp Cys Arg Thr Pro Tyr Pro His Thr Gly Lys Met Thr Arg Val 
    610                 615                 620                 


Pro Leu Arg Ser Thr Tyr Asn Tyr 
625                 630         


<210>  355
<211>  662
<212>  PRT
<213>  Ghanaian bat henipavirus

<400>  355

Met Lys Lys Lys Thr Asp Asn Pro Thr Ile Ser Lys Arg Gly His Asn 
1               5                   10                  15      


His Ser Arg Gly Ile Lys Ser Arg Ala Leu Leu Arg Glu Thr Asp Asn 
            20                  25                  30          


Tyr Ser Asn Gly Leu Ile Val Glu Asn Leu Val Arg Asn Cys His His 
        35                  40                  45              


Pro Ser Lys Asn Asn Leu Asn Tyr Thr Lys Thr Gln Lys Arg Asp Ser 
    50                  55                  60                  


Thr Ile Pro Tyr Arg Val Glu Glu Arg Lys Gly His Tyr Pro Lys Ile 
65                  70                  75                  80  


Lys His Leu Ile Asp Lys Ser Tyr Lys His Ile Lys Arg Gly Lys Arg 
                85                  90                  95      


Arg Asn Gly His Asn Gly Asn Ile Ile Thr Ile Ile Leu Leu Leu Ile 
            100                 105                 110         


Leu Ile Leu Lys Thr Gln Met Ser Glu Gly Ala Ile His Tyr Glu Thr 
        115                 120                 125             


Leu Ser Lys Ile Gly Leu Ile Lys Gly Ile Thr Arg Glu Tyr Lys Val 
    130                 135                 140                 


Lys Gly Thr Pro Ser Ser Lys Asp Ile Val Ile Lys Leu Ile Pro Asn 
145                 150                 155                 160 


Val Thr Gly Leu Asn Lys Cys Thr Asn Ile Ser Met Glu Asn Tyr Lys 
                165                 170                 175     


Glu Gln Leu Asp Lys Ile Leu Ile Pro Ile Asn Asn Ile Ile Glu Leu 
            180                 185                 190         


Tyr Ala Asn Ser Thr Lys Ser Ala Pro Gly Asn Ala Arg Phe Ala Gly 
        195                 200                 205             


Val Ile Ile Ala Gly Val Ala Leu Gly Val Ala Ala Ala Ala Gln Ile 
    210                 215                 220                 


Thr Ala Gly Ile Ala Leu His Glu Ala Arg Gln Asn Ala Glu Arg Ile 
225                 230                 235                 240 


Asn Leu Leu Lys Asp Ser Ile Ser Ala Thr Asn Asn Ala Val Ala Glu 
                245                 250                 255     


Leu Gln Glu Ala Thr Gly Gly Ile Val Asn Val Ile Thr Gly Met Gln 
            260                 265                 270         


Asp Tyr Ile Asn Thr Asn Leu Val Pro Gln Ile Asp Lys Leu Gln Cys 
        275                 280                 285             


Ser Gln Ile Lys Thr Ala Leu Asp Ile Ser Leu Ser Gln Tyr Tyr Ser 
    290                 295                 300                 


Glu Ile Leu Thr Val Phe Gly Pro Asn Leu Gln Asn Pro Val Thr Thr 
305                 310                 315                 320 


Ser Met Ser Ile Gln Ala Ile Ser Gln Ser Phe Gly Gly Asn Ile Asp 
                325                 330                 335     


Leu Leu Leu Asn Leu Leu Gly Tyr Thr Ala Asn Asp Leu Leu Asp Leu 
            340                 345                 350         


Leu Glu Ser Lys Ser Ile Thr Gly Gln Ile Thr Tyr Ile Asn Leu Glu 
        355                 360                 365             


His Tyr Phe Met Val Ile Arg Val Tyr Tyr Pro Ile Met Thr Thr Ile 
    370                 375                 380                 


Ser Asn Ala Tyr Val Gln Glu Leu Ile Lys Ile Ser Phe Asn Val Asp 
385                 390                 395                 400 


Gly Ser Glu Trp Val Ser Leu Val Pro Ser Tyr Ile Leu Ile Arg Asn 
                405                 410                 415     


Ser Tyr Leu Ser Asn Ile Asp Ile Ser Glu Cys Leu Ile Thr Lys Asn 
            420                 425                 430         


Ser Val Ile Cys Arg His Asp Phe Ala Met Pro Met Ser Tyr Thr Leu 
        435                 440                 445             


Lys Glu Cys Leu Thr Gly Asp Thr Glu Lys Cys Pro Arg Glu Ala Val 
    450                 455                 460                 


Val Thr Ser Tyr Val Pro Arg Phe Ala Ile Ser Gly Gly Val Ile Tyr 
465                 470                 475                 480 


Ala Asn Cys Leu Ser Thr Thr Cys Gln Cys Tyr Gln Thr Gly Lys Val 
                485                 490                 495     


Ile Ala Gln Asp Gly Ser Gln Thr Leu Met Met Ile Asp Asn Gln Thr 
            500                 505                 510         


Cys Ser Ile Val Arg Ile Glu Glu Ile Leu Ile Ser Thr Gly Lys Tyr 
        515                 520                 525             


Leu Gly Ser Gln Glu Tyr Asn Thr Met His Val Ser Val Gly Asn Pro 
    530                 535                 540                 


Val Phe Thr Asp Lys Leu Asp Ile Thr Ser Gln Ile Ser Asn Ile Asn 
545                 550                 555                 560 


Gln Ser Ile Glu Gln Ser Lys Phe Tyr Leu Asp Lys Ser Lys Ala Ile 
                565                 570                 575     


Leu Asp Lys Ile Asn Leu Asn Leu Ile Gly Ser Val Pro Ile Ser Ile 
            580                 585                 590         


Leu Phe Ile Ile Ala Ile Leu Ser Leu Ile Leu Ser Ile Ile Thr Phe 
        595                 600                 605             


Val Ile Val Met Ile Ile Val Arg Arg Tyr Asn Lys Tyr Thr Pro Leu 
    610                 615                 620                 


Ile Asn Ser Asp Pro Ser Ser Arg Arg Ser Thr Ile Gln Asp Val Tyr 
625                 630                 635                 640 


Ile Ile Pro Asn Pro Gly Glu His Ser Ile Arg Ser Ala Ala Arg Ser 
                645                 650                 655     


Ile Asp Arg Asp Arg Asp 
            660         


<210>  356
<211>  604
<212>  PRT
<213>  Hendra henipavirus

<400>  356

Met Met Ala Asp Ser Lys Leu Val Ser Leu Asn Asn Asn Leu Ser Gly 
1               5                   10                  15      


Lys Ile Lys Asp Gln Gly Lys Val Ile Lys Asn Tyr Tyr Gly Thr Met 
            20                  25                  30          


Asp Ile Lys Lys Ile Asn Asp Gly Leu Leu Asp Ser Lys Ile Leu Gly 
        35                  40                  45              


Ala Phe Asn Thr Val Ile Ala Leu Leu Gly Ser Ile Ile Ile Ile Val 
    50                  55                  60                  


Met Asn Ile Met Ile Ile Gln Asn Tyr Thr Arg Thr Thr Asp Asn Gln 
65                  70                  75                  80  


Ala Leu Ile Lys Glu Ser Leu Gln Ser Val Gln Gln Gln Ile Lys Ala 
                85                  90                  95      


Leu Thr Asp Lys Ile Gly Thr Glu Ile Gly Pro Lys Val Ser Leu Ile 
            100                 105                 110         


Asp Thr Ser Ser Thr Ile Thr Ile Pro Ala Asn Ile Gly Leu Leu Gly 
        115                 120                 125             


Ser Lys Ile Ser Gln Ser Thr Ser Ser Ile Asn Glu Asn Val Asn Asp 
    130                 135                 140                 


Lys Cys Lys Phe Thr Leu Pro Pro Leu Lys Ile His Glu Cys Asn Ile 
145                 150                 155                 160 


Ser Cys Pro Asn Pro Leu Pro Phe Arg Glu Tyr Arg Pro Ile Ser Gln 
                165                 170                 175     


Gly Val Ser Asp Leu Val Gly Leu Pro Asn Gln Ile Cys Leu Gln Lys 
            180                 185                 190         


Thr Thr Ser Thr Ile Leu Lys Pro Arg Leu Ile Ser Tyr Thr Leu Pro 
        195                 200                 205             


Ile Asn Thr Arg Glu Gly Val Cys Ile Thr Asp Pro Leu Leu Ala Val 
    210                 215                 220                 


Asp Asn Gly Phe Phe Ala Tyr Ser His Leu Glu Lys Ile Gly Ser Cys 
225                 230                 235                 240 


Thr Arg Gly Ile Ala Lys Gln Arg Ile Ile Gly Val Gly Glu Val Leu 
                245                 250                 255     


Asp Arg Gly Asp Lys Val Pro Ser Met Phe Met Thr Asn Val Trp Thr 
            260                 265                 270         


Pro Pro Asn Pro Ser Thr Ile His His Cys Ser Ser Thr Tyr His Glu 
        275                 280                 285             


Asp Phe Tyr Tyr Thr Leu Cys Ala Val Ser His Val Gly Asp Pro Ile 
    290                 295                 300                 


Leu Asn Ser Thr Ser Trp Thr Glu Ser Leu Ser Leu Ile Arg Leu Ala 
305                 310                 315                 320 


Val Arg Pro Lys Ser Asp Ser Gly Asp Tyr Asn Gln Lys Tyr Ile Ala 
                325                 330                 335     


Ile Thr Lys Val Glu Arg Gly Lys Tyr Asp Lys Val Met Pro Tyr Gly 
            340                 345                 350         


Pro Ser Gly Ile Lys Gln Gly Asp Thr Leu Tyr Phe Pro Ala Val Gly 
        355                 360                 365             


Phe Leu Pro Arg Thr Glu Phe Gln Tyr Asn Asp Ser Asn Cys Pro Ile 
    370                 375                 380                 


Ile His Cys Lys Tyr Ser Lys Ala Glu Asn Cys Arg Leu Ser Met Gly 
385                 390                 395                 400 


Val Asn Ser Lys Ser His Tyr Ile Leu Arg Ser Gly Leu Leu Lys Tyr 
                405                 410                 415     


Asn Leu Ser Leu Gly Gly Asp Ile Ile Leu Gln Phe Ile Glu Ile Ala 
            420                 425                 430         


Asp Asn Arg Leu Thr Ile Gly Ser Pro Ser Lys Ile Tyr Asn Ser Leu 
        435                 440                 445             


Gly Gln Pro Val Phe Tyr Gln Ala Ser Tyr Ser Trp Asp Thr Met Ile 
    450                 455                 460                 


Lys Leu Gly Asp Val Asp Thr Val Asp Pro Leu Arg Val Gln Trp Arg 
465                 470                 475                 480 


Asn Asn Ser Val Ile Ser Arg Pro Gly Gln Ser Gln Cys Pro Arg Phe 
                485                 490                 495     


Asn Val Cys Pro Glu Val Cys Trp Glu Gly Thr Tyr Asn Asp Ala Phe 
            500                 505                 510         


Leu Ile Asp Arg Leu Asn Trp Val Ser Ala Gly Val Tyr Leu Asn Ser 
        515                 520                 525             


Asn Gln Thr Ala Glu Asn Pro Val Phe Ala Val Phe Lys Asp Asn Glu 
    530                 535                 540                 


Ile Leu Tyr Gln Val Pro Leu Ala Glu Asp Asp Thr Asn Ala Gln Lys 
545                 550                 555                 560 


Thr Ile Thr Asp Cys Phe Leu Leu Glu Asn Val Ile Trp Cys Ile Ser 
                565                 570                 575     


Leu Val Glu Ile Tyr Asp Thr Gly Asp Ser Val Ile Arg Pro Lys Leu 
            580                 585                 590         


Phe Ala Val Lys Ile Pro Ala Gln Cys Ser Glu Ser 
        595                 600                 


<210>  357
<211>  546
<212>  PRT
<213>  Hendra henipavirus

<400>  357

Met Ala Thr Gln Glu Val Arg Leu Lys Cys Leu Leu Cys Gly Ile Ile 
1               5                   10                  15      


Val Leu Val Leu Ser Leu Glu Gly Leu Gly Ile Leu His Tyr Glu Lys 
            20                  25                  30          


Leu Ser Lys Ile Gly Leu Val Lys Gly Ile Thr Arg Lys Tyr Lys Ile 
        35                  40                  45              


Lys Ser Asn Pro Leu Thr Lys Asp Ile Val Ile Lys Met Ile Pro Asn 
    50                  55                  60                  


Val Ser Asn Val Ser Lys Cys Thr Gly Thr Val Met Glu Asn Tyr Lys 
65                  70                  75                  80  


Ser Arg Leu Thr Gly Ile Leu Ser Pro Ile Lys Gly Ala Ile Glu Leu 
                85                  90                  95      


Tyr Asn Asn Asn Thr His Asp Leu Val Gly Asp Val Lys Leu Ala Gly 
            100                 105                 110         


Val Val Met Ala Gly Ile Ala Ile Gly Ile Ala Thr Ala Ala Gln Ile 
        115                 120                 125             


Thr Ala Gly Val Ala Leu Tyr Glu Ala Met Lys Asn Ala Asp Asn Ile 
    130                 135                 140                 


Asn Lys Leu Lys Ser Ser Ile Glu Ser Thr Asn Glu Ala Val Val Lys 
145                 150                 155                 160 


Leu Gln Glu Thr Ala Glu Lys Thr Val Tyr Val Leu Thr Ala Leu Gln 
                165                 170                 175     


Asp Tyr Ile Asn Thr Asn Leu Val Pro Thr Ile Asp Gln Ile Ser Cys 
            180                 185                 190         


Lys Gln Thr Glu Leu Ala Leu Asp Leu Ala Leu Ser Lys Tyr Leu Ser 
        195                 200                 205             


Asp Leu Leu Phe Val Phe Gly Pro Asn Leu Gln Asp Pro Val Ser Asn 
    210                 215                 220                 


Ser Met Thr Ile Gln Ala Ile Ser Gln Ala Phe Gly Gly Asn Tyr Glu 
225                 230                 235                 240 


Thr Leu Leu Arg Thr Leu Gly Tyr Ala Thr Glu Asp Phe Asp Asp Leu 
                245                 250                 255     


Leu Glu Ser Asp Ser Ile Ala Gly Gln Ile Val Tyr Val Asp Leu Ser 
            260                 265                 270         


Ser Tyr Tyr Ile Ile Val Arg Val Tyr Phe Pro Ile Leu Thr Glu Ile 
        275                 280                 285             


Gln Gln Ala Tyr Val Gln Glu Leu Leu Pro Val Ser Phe Asn Asn Asp 
    290                 295                 300                 


Asn Ser Glu Trp Ile Ser Ile Val Pro Asn Phe Val Leu Ile Arg Asn 
305                 310                 315                 320 


Thr Leu Ile Ser Asn Ile Glu Val Lys Tyr Cys Leu Ile Thr Lys Lys 
                325                 330                 335     


Ser Val Ile Cys Asn Gln Asp Tyr Ala Thr Pro Met Thr Ala Ser Val 
            340                 345                 350         


Arg Glu Cys Leu Thr Gly Ser Thr Asp Lys Cys Pro Arg Glu Leu Val 
        355                 360                 365             


Val Ser Ser His Val Pro Arg Phe Ala Leu Ser Gly Gly Val Leu Phe 
    370                 375                 380                 


Ala Asn Cys Ile Ser Val Thr Cys Gln Cys Gln Thr Thr Gly Arg Ala 
385                 390                 395                 400 


Ile Ser Gln Ser Gly Glu Gln Thr Leu Leu Met Ile Asp Asn Thr Thr 
                405                 410                 415     


Cys Thr Thr Val Val Leu Gly Asn Ile Ile Ile Ser Leu Gly Lys Tyr 
            420                 425                 430         


Leu Gly Ser Ile Asn Tyr Asn Ser Glu Ser Ile Ala Val Gly Pro Pro 
        435                 440                 445             


Val Tyr Thr Asp Lys Val Asp Ile Ser Ser Gln Ile Ser Ser Met Asn 
    450                 455                 460                 


Gln Ser Leu Gln Gln Ser Lys Asp Tyr Ile Lys Glu Ala Gln Lys Ile 
465                 470                 475                 480 


Leu Asp Thr Val Asn Pro Ser Leu Ile Ser Met Leu Ser Met Ile Ile 
                485                 490                 495     


Leu Tyr Val Leu Ser Ile Ala Ala Leu Cys Ile Gly Leu Ile Thr Phe 
            500                 505                 510         


Ile Ser Phe Val Ile Val Glu Lys Lys Arg Gly Asn Tyr Ser Arg Leu 
        515                 520                 525             


Asp Asp Arg Gln Val Arg Pro Val Ser Asn Gly Asp Leu Tyr Tyr Ile 
    530                 535                 540                 


Gly Thr 
545     


<210>  358
<211>  625
<212>  PRT
<213>  Mojiang henipavirus

<400>  358

Met Ala Thr Asn Arg Asp Asn Thr Ile Thr Ser Ala Glu Val Ser Gln 
1               5                   10                  15      


Glu Asp Lys Val Lys Lys Tyr Tyr Gly Val Glu Thr Ala Glu Lys Val 
            20                  25                  30          


Ala Asp Ser Ile Ser Gly Asn Lys Val Phe Ile Leu Met Asn Thr Leu 
        35                  40                  45              


Leu Ile Leu Thr Gly Ala Ile Ile Thr Ile Thr Leu Asn Ile Thr Asn 
    50                  55                  60                  


Leu Thr Ala Ala Lys Ser Gln Gln Asn Met Leu Lys Ile Ile Gln Asp 
65                  70                  75                  80  


Asp Val Asn Ala Lys Leu Glu Met Phe Val Asn Leu Asp Gln Leu Val 
                85                  90                  95      


Lys Gly Glu Ile Lys Pro Lys Val Ser Leu Ile Asn Thr Ala Val Ser 
            100                 105                 110         


Val Ser Ile Pro Gly Gln Ile Ser Asn Leu Gln Thr Lys Phe Leu Gln 
        115                 120                 125             


Lys Tyr Val Tyr Leu Glu Glu Ser Ile Thr Lys Gln Cys Thr Cys Asn 
    130                 135                 140                 


Pro Leu Ser Gly Ile Phe Pro Thr Ser Gly Pro Thr Tyr Pro Pro Thr 
145                 150                 155                 160 


Asp Lys Pro Asp Asp Asp Thr Thr Asp Asp Asp Lys Val Asp Thr Thr 
                165                 170                 175     


Ile Lys Pro Ile Glu Tyr Pro Lys Pro Asp Gly Cys Asn Arg Thr Gly 
            180                 185                 190         


Asp His Phe Thr Met Glu Pro Gly Ala Asn Phe Tyr Thr Val Pro Asn 
        195                 200                 205             


Leu Gly Pro Ala Ser Ser Asn Ser Asp Glu Cys Tyr Thr Asn Pro Ser 
    210                 215                 220                 


Phe Ser Ile Gly Ser Ser Ile Tyr Met Phe Ser Gln Glu Ile Arg Lys 
225                 230                 235                 240 


Thr Asp Cys Thr Ala Gly Glu Ile Leu Ser Ile Gln Ile Val Leu Gly 
                245                 250                 255     


Arg Ile Val Asp Lys Gly Gln Gln Gly Pro Gln Ala Ser Pro Leu Leu 
            260                 265                 270         


Val Trp Ala Val Pro Asn Pro Lys Ile Ile Asn Ser Cys Ala Val Ala 
        275                 280                 285             


Ala Gly Asp Glu Met Gly Trp Val Leu Cys Ser Val Thr Leu Thr Ala 
    290                 295                 300                 


Ala Ser Gly Glu Pro Ile Pro His Met Phe Asp Gly Phe Trp Leu Tyr 
305                 310                 315                 320 


Lys Leu Glu Pro Asp Thr Glu Val Val Ser Tyr Arg Ile Thr Gly Tyr 
                325                 330                 335     


Ala Tyr Leu Leu Asp Lys Gln Tyr Asp Ser Val Phe Ile Gly Lys Gly 
            340                 345                 350         


Gly Gly Ile Gln Lys Gly Asn Asp Leu Tyr Phe Gln Met Tyr Gly Leu 
        355                 360                 365             


Ser Arg Asn Arg Gln Ser Phe Lys Ala Leu Cys Glu His Gly Ser Cys 
    370                 375                 380                 


Leu Gly Thr Gly Gly Gly Gly Tyr Gln Val Leu Cys Asp Arg Ala Val 
385                 390                 395                 400 


Met Ser Phe Gly Ser Glu Glu Ser Leu Ile Thr Asn Ala Tyr Leu Lys 
                405                 410                 415     


Val Asn Asp Leu Ala Ser Gly Lys Pro Val Ile Ile Gly Gln Thr Phe 
            420                 425                 430         


Pro Pro Ser Asp Ser Tyr Lys Gly Ser Asn Gly Arg Met Tyr Thr Ile 
        435                 440                 445             


Gly Asp Lys Tyr Gly Leu Tyr Leu Ala Pro Ser Ser Trp Asn Arg Tyr 
    450                 455                 460                 


Leu Arg Phe Gly Ile Thr Pro Asp Ile Ser Val Arg Ser Thr Thr Trp 
465                 470                 475                 480 


Leu Lys Ser Gln Asp Pro Ile Met Lys Ile Leu Ser Thr Cys Thr Asn 
                485                 490                 495     


Thr Asp Arg Asp Met Cys Pro Glu Ile Cys Asn Thr Arg Gly Tyr Gln 
            500                 505                 510         


Asp Ile Phe Pro Leu Ser Glu Asp Ser Glu Tyr Tyr Thr Tyr Ile Gly 
        515                 520                 525             


Ile Thr Pro Asn Asn Gly Gly Thr Lys Asn Phe Val Ala Val Arg Asp 
    530                 535                 540                 


Ser Asp Gly His Ile Ala Ser Ile Asp Ile Leu Gln Asn Tyr Tyr Ser 
545                 550                 555                 560 


Ile Thr Ser Ala Thr Ile Ser Cys Phe Met Tyr Lys Asp Glu Ile Trp 
                565                 570                 575     


Cys Ile Ala Ile Thr Glu Gly Lys Lys Gln Lys Asp Asn Pro Gln Arg 
            580                 585                 590         


Ile Tyr Ala His Ser Tyr Lys Ile Arg Gln Met Cys Tyr Asn Met Lys 
        595                 600                 605             


Ser Ala Thr Val Thr Val Gly Asn Ala Lys Asn Ile Thr Ile Arg Arg 
    610                 615                 620                 


Tyr 
625 


<210>  359
<211>  545
<212>  PRT
<213>  Mojiang henipavirus

<400>  359

Met Ala Leu Asn Lys Asn Met Phe Ser Ser Leu Phe Leu Gly Tyr Leu 
1               5                   10                  15      


Leu Val Tyr Ala Thr Thr Val Gln Ser Ser Ile His Tyr Asp Ser Leu 
            20                  25                  30          


Ser Lys Val Gly Val Ile Lys Gly Leu Thr Tyr Asn Tyr Lys Ile Lys 
        35                  40                  45              


Gly Ser Pro Ser Thr Lys Leu Met Val Val Lys Leu Ile Pro Asn Ile 
    50                  55                  60                  


Asp Ser Val Lys Asn Cys Thr Gln Lys Gln Tyr Asp Glu Tyr Lys Asn 
65                  70                  75                  80  


Leu Val Arg Lys Ala Leu Glu Pro Val Lys Met Ala Ile Asp Thr Met 
                85                  90                  95      


Leu Asn Asn Val Lys Ser Gly Asn Asn Lys Tyr Arg Phe Ala Gly Ala 
            100                 105                 110         


Ile Met Ala Gly Val Ala Leu Gly Val Ala Thr Ala Ala Thr Val Thr 
        115                 120                 125             


Ala Gly Ile Ala Leu His Arg Ser Asn Glu Asn Ala Gln Ala Ile Ala 
    130                 135                 140                 


Asn Met Lys Ser Ala Ile Gln Asn Thr Asn Glu Ala Val Lys Gln Leu 
145                 150                 155                 160 


Gln Leu Ala Asn Lys Gln Thr Leu Ala Val Ile Asp Thr Ile Arg Gly 
                165                 170                 175     


Glu Ile Asn Asn Asn Ile Ile Pro Val Ile Asn Gln Leu Ser Cys Asp 
            180                 185                 190         


Thr Ile Gly Leu Ser Val Gly Ile Arg Leu Thr Gln Tyr Tyr Ser Glu 
        195                 200                 205             


Ile Ile Thr Ala Phe Gly Pro Ala Leu Gln Asn Pro Val Asn Thr Arg 
    210                 215                 220                 


Ile Thr Ile Gln Ala Ile Ser Ser Val Phe Asn Gly Asn Phe Asp Glu 
225                 230                 235                 240 


Leu Leu Lys Ile Met Gly Tyr Thr Ser Gly Asp Leu Tyr Glu Ile Leu 
                245                 250                 255     


His Ser Glu Leu Ile Arg Gly Asn Ile Ile Asp Val Asp Val Asp Ala 
            260                 265                 270         


Gly Tyr Ile Ala Leu Glu Ile Glu Phe Pro Asn Leu Thr Leu Val Pro 
        275                 280                 285             


Asn Ala Val Val Gln Glu Leu Met Pro Ile Ser Tyr Asn Ile Asp Gly 
    290                 295                 300                 


Asp Glu Trp Val Thr Leu Val Pro Arg Phe Val Leu Thr Arg Thr Thr 
305                 310                 315                 320 


Leu Leu Ser Asn Ile Asp Thr Ser Arg Cys Thr Ile Thr Asp Ser Ser 
                325                 330                 335     


Val Ile Cys Asp Asn Asp Tyr Ala Leu Pro Met Ser His Glu Leu Ile 
            340                 345                 350         


Gly Cys Leu Gln Gly Asp Thr Ser Lys Cys Ala Arg Glu Lys Val Val 
        355                 360                 365             


Ser Ser Tyr Val Pro Lys Phe Ala Leu Ser Asp Gly Leu Val Tyr Ala 
    370                 375                 380                 


Asn Cys Leu Asn Thr Ile Cys Arg Cys Met Asp Thr Asp Thr Pro Ile 
385                 390                 395                 400 


Ser Gln Ser Leu Gly Ala Thr Val Ser Leu Leu Asp Asn Lys Arg Cys 
                405                 410                 415     


Ser Val Tyr Gln Val Gly Asp Val Leu Ile Ser Val Gly Ser Tyr Leu 
            420                 425                 430         


Gly Asp Gly Glu Tyr Asn Ala Asp Asn Val Glu Leu Gly Pro Pro Ile 
        435                 440                 445             


Val Ile Asp Lys Ile Asp Ile Gly Asn Gln Leu Ala Gly Ile Asn Gln 
    450                 455                 460                 


Thr Leu Gln Glu Ala Glu Asp Tyr Ile Glu Lys Ser Glu Glu Phe Leu 
465                 470                 475                 480 


Lys Gly Val Asn Pro Ser Ile Ile Thr Leu Gly Ser Met Val Val Leu 
                485                 490                 495     


Tyr Ile Phe Met Ile Leu Ile Ala Ile Val Ser Val Ile Ala Leu Val 
            500                 505                 510         


Leu Ser Ile Lys Leu Thr Val Lys Gly Asn Val Val Arg Gln Gln Phe 
        515                 520                 525             


Thr Tyr Thr Gln His Val Pro Ser Met Glu Asn Ile Asn Tyr Val Ser 
    530                 535                 540                 


His 
545 


<210>  360
<211>  602
<212>  PRT
<213>  Nipah henipavirus

<400>  360

Met Pro Ala Glu Asn Lys Lys Val Arg Phe Glu Asn Thr Thr Ser Asp 
1               5                   10                  15      


Lys Gly Lys Ile Pro Ser Lys Val Ile Lys Ser Tyr Tyr Gly Thr Met 
            20                  25                  30          


Asp Ile Lys Lys Ile Asn Glu Gly Leu Leu Asp Ser Lys Ile Leu Ser 
        35                  40                  45              


Ala Phe Asn Thr Val Ile Ala Leu Leu Gly Ser Ile Val Ile Ile Val 
    50                  55                  60                  


Met Asn Ile Met Ile Ile Gln Asn Tyr Thr Arg Ser Thr Asp Asn Gln 
65                  70                  75                  80  


Ala Val Ile Lys Asp Ala Leu Gln Gly Ile Gln Gln Gln Ile Lys Gly 
                85                  90                  95      


Leu Ala Asp Lys Ile Gly Thr Glu Ile Gly Pro Lys Val Ser Leu Ile 
            100                 105                 110         


Asp Thr Ser Ser Thr Ile Thr Ile Pro Ala Asn Ile Gly Leu Leu Gly 
        115                 120                 125             


Ser Lys Ile Ser Gln Ser Thr Ala Ser Ile Asn Glu Asn Val Asn Glu 
    130                 135                 140                 


Lys Cys Lys Phe Thr Leu Pro Pro Leu Lys Ile His Glu Cys Asn Ile 
145                 150                 155                 160 


Ser Cys Pro Asn Pro Leu Pro Phe Arg Glu Tyr Arg Pro Gln Thr Glu 
                165                 170                 175     


Gly Val Ser Asn Leu Val Gly Leu Pro Asn Asn Ile Cys Leu Gln Lys 
            180                 185                 190         


Thr Ser Asn Gln Ile Leu Lys Pro Lys Leu Ile Ser Tyr Thr Leu Pro 
        195                 200                 205             


Val Val Gly Gln Ser Gly Thr Cys Ile Thr Asp Pro Leu Leu Ala Met 
    210                 215                 220                 


Asp Glu Gly Tyr Phe Ala Tyr Ser His Leu Glu Arg Ile Gly Ser Cys 
225                 230                 235                 240 


Ser Arg Gly Val Ser Lys Gln Arg Ile Ile Gly Val Gly Glu Val Leu 
                245                 250                 255     


Asp Arg Gly Asp Glu Val Pro Ser Leu Phe Met Thr Asn Val Trp Thr 
            260                 265                 270         


Pro Pro Asn Pro Asn Thr Val Tyr His Cys Ser Ala Val Tyr Asn Asn 
        275                 280                 285             


Glu Phe Tyr Tyr Val Leu Cys Ala Val Ser Thr Val Gly Asp Pro Ile 
    290                 295                 300                 


Leu Asn Ser Thr Tyr Trp Ser Gly Ser Leu Met Met Thr Arg Leu Ala 
305                 310                 315                 320 


Val Lys Pro Lys Ser Asn Gly Gly Gly Tyr Asn Gln His Gln Leu Ala 
                325                 330                 335     


Leu Arg Ser Ile Glu Lys Gly Arg Tyr Asp Lys Val Met Pro Tyr Gly 
            340                 345                 350         


Pro Ser Gly Ile Lys Gln Gly Asp Thr Leu Tyr Phe Pro Ala Val Gly 
        355                 360                 365             


Phe Leu Val Arg Thr Glu Phe Lys Tyr Asn Asp Ser Asn Cys Pro Ile 
    370                 375                 380                 


Thr Lys Cys Gln Tyr Ser Lys Pro Glu Asn Cys Arg Leu Ser Met Gly 
385                 390                 395                 400 


Ile Arg Pro Asn Ser His Tyr Ile Leu Arg Ser Gly Leu Leu Lys Tyr 
                405                 410                 415     


Asn Leu Ser Asp Gly Glu Asn Pro Lys Val Val Phe Ile Glu Ile Ser 
            420                 425                 430         


Asp Gln Arg Leu Ser Ile Gly Ser Pro Ser Lys Ile Tyr Asp Ser Leu 
        435                 440                 445             


Gly Gln Pro Val Phe Tyr Gln Ala Ser Phe Ser Trp Asp Thr Met Ile 
    450                 455                 460                 


Lys Phe Gly Asp Val Leu Thr Val Asn Pro Leu Val Val Asn Trp Arg 
465                 470                 475                 480 


Asn Asn Thr Val Ile Ser Arg Pro Gly Gln Ser Gln Cys Pro Arg Phe 
                485                 490                 495     


Asn Thr Cys Pro Glu Ile Cys Trp Glu Gly Val Tyr Asn Asp Ala Phe 
            500                 505                 510         


Leu Ile Asp Arg Ile Asn Trp Ile Ser Ala Gly Val Phe Leu Asp Ser 
        515                 520                 525             


Asn Gln Thr Ala Glu Asn Pro Val Phe Thr Val Phe Lys Asp Asn Glu 
    530                 535                 540                 


Ile Leu Tyr Arg Ala Gln Leu Ala Ser Glu Asp Thr Asn Ala Gln Lys 
545                 550                 555                 560 


Thr Ile Thr Asn Cys Phe Leu Leu Lys Asn Lys Ile Trp Cys Ile Ser 
                565                 570                 575     


Leu Val Glu Ile Tyr Asp Thr Gly Asp Asn Val Ile Arg Pro Lys Leu 
            580                 585                 590         


Phe Ala Val Lys Ile Pro Glu Gln Cys Thr 
        595                 600         


<210>  361
<211>  546
<212>  PRT
<213>  Nipah henipavirus

<400>  361

Met Val Val Ile Leu Asp Lys Arg Cys Tyr Cys Asn Leu Leu Ile Leu 
1               5                   10                  15      


Ile Leu Met Ile Ser Glu Cys Ser Val Gly Ile Leu His Tyr Glu Lys 
            20                  25                  30          


Leu Ser Lys Ile Gly Leu Val Lys Gly Val Thr Arg Lys Tyr Lys Ile 
        35                  40                  45              


Lys Ser Asn Pro Leu Thr Lys Asp Ile Val Ile Lys Met Ile Pro Asn 
    50                  55                  60                  


Val Ser Asn Met Ser Gln Cys Thr Gly Ser Val Met Glu Asn Tyr Lys 
65                  70                  75                  80  


Thr Arg Leu Asn Gly Ile Leu Thr Pro Ile Lys Gly Ala Leu Glu Ile 
                85                  90                  95      


Tyr Lys Asn Asn Thr His Asp Leu Val Gly Asp Val Arg Leu Ala Gly 
            100                 105                 110         


Val Ile Met Ala Gly Val Ala Ile Gly Ile Ala Thr Ala Ala Gln Ile 
        115                 120                 125             


Thr Ala Gly Val Ala Leu Tyr Glu Ala Met Lys Asn Ala Asp Asn Ile 
    130                 135                 140                 


Asn Lys Leu Lys Ser Ser Ile Glu Ser Thr Asn Glu Ala Val Val Lys 
145                 150                 155                 160 


Leu Gln Glu Thr Ala Glu Lys Thr Val Tyr Val Leu Thr Ala Leu Gln 
                165                 170                 175     


Asp Tyr Ile Asn Thr Asn Leu Val Pro Thr Ile Asp Lys Ile Ser Cys 
            180                 185                 190         


Lys Gln Thr Glu Leu Ser Leu Asp Leu Ala Leu Ser Lys Tyr Leu Ser 
        195                 200                 205             


Asp Leu Leu Phe Val Phe Gly Pro Asn Leu Gln Asp Pro Val Ser Asn 
    210                 215                 220                 


Ser Met Thr Ile Gln Ala Ile Ser Gln Ala Phe Gly Gly Asn Tyr Glu 
225                 230                 235                 240 


Thr Leu Leu Arg Thr Leu Gly Tyr Ala Thr Glu Asp Phe Asp Asp Leu 
                245                 250                 255     


Leu Glu Ser Asp Ser Ile Thr Gly Gln Ile Ile Tyr Val Asp Leu Ser 
            260                 265                 270         


Ser Tyr Tyr Ile Ile Val Arg Val Tyr Phe Pro Ile Leu Thr Glu Ile 
        275                 280                 285             


Gln Gln Ala Tyr Ile Gln Glu Leu Leu Pro Val Ser Phe Asn Asn Asp 
    290                 295                 300                 


Asn Ser Glu Trp Ile Ser Ile Val Pro Asn Phe Ile Leu Val Arg Asn 
305                 310                 315                 320 


Thr Leu Ile Ser Asn Ile Glu Ile Gly Phe Cys Leu Ile Thr Lys Arg 
                325                 330                 335     


Ser Val Ile Cys Asn Gln Asp Tyr Ala Thr Pro Met Thr Asn Asn Met 
            340                 345                 350         


Arg Glu Cys Leu Thr Gly Ser Thr Glu Lys Cys Pro Arg Glu Leu Val 
        355                 360                 365             


Val Ser Ser His Val Pro Arg Phe Ala Leu Ser Asn Gly Val Leu Phe 
    370                 375                 380                 


Ala Asn Cys Ile Ser Val Thr Cys Gln Cys Gln Thr Thr Gly Arg Ala 
385                 390                 395                 400 


Ile Ser Gln Ser Gly Glu Gln Thr Leu Leu Met Ile Asp Asn Thr Thr 
                405                 410                 415     


Cys Pro Thr Ala Val Leu Gly Asn Val Ile Ile Ser Leu Gly Lys Tyr 
            420                 425                 430         


Leu Gly Ser Val Asn Tyr Asn Ser Glu Gly Ile Ala Ile Gly Pro Pro 
        435                 440                 445             


Val Phe Thr Asp Lys Val Asp Ile Ser Ser Gln Ile Ser Ser Met Asn 
    450                 455                 460                 


Gln Ser Leu Gln Gln Ser Lys Asp Tyr Ile Lys Glu Ala Gln Arg Leu 
465                 470                 475                 480 


Leu Asp Thr Val Asn Pro Ser Leu Ile Ser Met Leu Ser Met Ile Ile 
                485                 490                 495     


Leu Tyr Val Leu Ser Ile Ala Ser Leu Cys Ile Gly Leu Ile Thr Phe 
            500                 505                 510         


Ile Ser Phe Ile Ile Val Glu Lys Lys Arg Asn Thr Tyr Ser Arg Leu 
        515                 520                 525             


Glu Asp Arg Arg Val Arg Pro Thr Ser Ser Gly Asp Leu Tyr Tyr Ile 
    530                 535                 540                 


Gly Thr 
545     


<210>  362
<211>  544
<212>  PRT
<213>  Beilong jeilongvirus

<400>  362

Met Lys Val Thr Ile Leu Thr Ala Tyr Ile Ala Ala Ser Val Phe Thr 
1               5                   10                  15      


Cys Cys His Ser Gln Leu Ala Leu Ser Glu Leu Thr Lys Ile Gly Ile 
            20                  25                  30          


Ile Pro Gly Arg Ser Tyr Asp Leu Lys Thr Ser Thr Gln Ala Ser Tyr 
        35                  40                  45              


Gln Tyr Met Val Ile Lys Leu Ile Pro Asn Val Asn Gly Leu Asn Asn 
    50                  55                  60                  


Cys Thr Asn Ser Thr Val Glu Ser Tyr Lys Lys Met Leu Thr Arg Leu 
65                  70                  75                  80  


Leu Asn Pro Ile Asp Val Ala Leu Lys Lys Met Lys Asn Ala Val Ser 
                85                  90                  95      


Asp Lys Ala Pro Glu Lys Leu Gly Asn Val Lys Phe Trp Gly Ala Val 
            100                 105                 110         


Ile Gly Gly Val Ala Leu Gly Val Ala Thr Ser Ala Gln Ile Thr Ala 
        115                 120                 125             


Gly Val Ala Leu His Asn Ser Ile Gln Asn Ala Asn Ala Ile Leu Thr 
    130                 135                 140                 


Leu Lys Asp Ser Ile Arg Gln Ser Asn Lys Ala Ile Gln Glu Leu Gln 
145                 150                 155                 160 


Thr Ala Met Ser Thr Thr Val Val Val Leu Asn Ala Leu Gln Asp Gln 
                165                 170                 175     


Ile Asn Asn Gln Leu Ala Pro Ala Ile Asn Ser Leu Gly Cys Gln Val 
            180                 185                 190         


Val Ala Asn Thr Leu Gly Leu Lys Leu Asn Gln Tyr Phe Ser Glu Ile 
        195                 200                 205             


Ser Leu Val Phe Gly Pro Asn Leu Arg Asp Pro Thr Ser Glu Thr Leu 
    210                 215                 220                 


Ser Ile Gln Ala Leu Ser Arg Ala Phe Asn Gly Asp Phe Asp Ser Met 
225                 230                 235                 240 


Leu Ser Arg Leu Lys Tyr Asp Asp Ser Asp Phe Leu Asp Leu Leu Glu 
                245                 250                 255     


Ser Asp Ser Ile Arg Gly Arg Ile Ile Asp Val Ser Leu Glu Asp Tyr 
            260                 265                 270         


Leu Ile Thr Ile Gln Ile Glu Tyr Pro Ala Leu Leu Thr Ile Lys Asp 
        275                 280                 285             


Ala Ile Ile Gln Thr Phe Asn Leu Ile Ser Tyr Asn Thr Arg Gly Thr 
    290                 295                 300                 


Glu Trp Ile Ser Ile Phe Pro Lys Gln Leu Leu Val Arg Gly Thr Tyr 
305                 310                 315                 320 


Ile Ser Asn Ile Asp Ile Ser Gln Cys Val Leu Ala Ala Thr Ser Ile 
                325                 330                 335     


Ile Cys Lys Ser Asp Thr Ser Thr Pro Ile Ser Ser Ala Thr Trp Ala 
            340                 345                 350         


Cys Ala Thr Gly Asn Val Thr Ser Cys Ala Arg Thr Arg Val Val Asn 
        355                 360                 365             


Ala His Val Pro Arg Phe Ala Leu Ser Gly Gly Val Ile Phe Ala Asn 
    370                 375                 380                 


Cys Ala Pro Val Val Cys Lys Cys Gln Asp Pro Leu Tyr Ser Ile Asn 
385                 390                 395                 400 


Gln Glu Pro Lys Val Thr Asn Val Met Val Asp Val Asp Ala Cys Lys 
                405                 410                 415     


Glu Met Tyr Leu Asp Gly Leu Tyr Ile Thr Leu Gly Lys Ser Gln Leu 
            420                 425                 430         


Pro Arg Ala Met Tyr Ala Glu Asp Val Ser Leu Gly Gly Pro Ile Ser 
        435                 440                 445             


Val Asp Leu Ile Asp Leu Gly Asn Glu Ile Asn Ser Ile Asn Ser Ala 
    450                 455                 460                 


Ile Asn Arg Ser Glu Glu His Leu Asp His Ala Asn Glu Leu Leu Asp 
465                 470                 475                 480 


Gln Val Asn Pro Lys Ile Val Asn Val Lys Thr Phe Gly Val Met Leu 
                485                 490                 495     


Gly Leu Leu Leu Leu Leu Ile Leu Trp Cys Val Val Thr Leu Val Trp 
            500                 505                 510         


Leu Ile Cys Leu Thr Lys Gln Val Ser Arg Val Ser Phe Gly Gly Ser 
        515                 520                 525             


Met Gly Ser Arg Ala Ser Thr Val Asn Ser Leu Ser Gly Phe Val Gly 
    530                 535                 540                 


<210>  363
<211>  734
<212>  PRT
<213>  Beilong jeilongvirus

<400>  363

Met Ser Gln Leu Ala Ala His Asn Leu Ala Met Ser Asn Phe Tyr Gly 
1               5                   10                  15      


Thr His Gln Gly Asp Leu Ser Gly Ser Gln Lys Gly Glu Glu Gln Gln 
            20                  25                  30          


Val Gln Gly Val Ile Arg Tyr Val Ser Met Ile Val Ser Leu Leu Ser 
        35                  40                  45              


Leu Phe Thr Ile Ile Ala Leu Asn Val Thr Asn Ile Ile Tyr Met Thr 
    50                  55                  60                  


Glu Ser Gly Gly Thr Met Gln Ser Ile Lys Thr Ala Gln Gly Ser Ile 
65                  70                  75                  80  


Asp Gly Ser Met Arg Glu Ile Ser Gly Val Ile Met Glu Asp Val Lys 
                85                  90                  95      


Pro Lys Thr Asp Leu Ile Asn Ser Met Val Ser Tyr Asn Ile Pro Ala 
            100                 105                 110         


Gln Leu Ser Met Ile His Gln Ile Ile Lys Asn Asp Val Pro Lys Gln 
        115                 120                 125             


Cys Thr Pro Ser Phe Met Phe Asn Asn Thr Ile Cys Pro Leu Ala Glu 
    130                 135                 140                 


Asn Pro Thr His Ser Arg Tyr Phe Glu Glu Val Asn Leu Asp Ser Ile 
145                 150                 155                 160 


Ser Glu Cys Ser Gly Pro Asp Met His Leu Gly Leu Gly Val Asn Pro 
                165                 170                 175     


Glu Phe Ile Glu Phe Pro Ser Phe Ala Pro Gly Ser Thr Lys Pro Gly 
            180                 185                 190         


Ser Cys Val Arg Leu Pro Ser Phe Ser Leu Ser Thr Thr Val Phe Ala 
        195                 200                 205             


Tyr Thr His Thr Ile Met Gly His Gly Cys Ser Glu Leu Asp Val Gly 
    210                 215                 220                 


Asp His Tyr Phe Ser Val Gly Arg Ile Ala Asp Ala Gly His Glu Ile 
225                 230                 235                 240 


Pro Gln Phe Glu Thr Ile Ser Ser Trp Phe Ile Asn Asp Lys Ile Asn 
                245                 250                 255     


Arg Arg Ser Cys Thr Val Ala Ala Gly Ala Met Glu Ala Trp Met Gly 
            260                 265                 270         


Cys Val Ile Met Thr Glu Thr Phe Tyr Asp Asp Arg Asn Ser Leu Asp 
        275                 280                 285             


Thr Gly Lys Leu Thr Ile Ser Tyr Leu Asp Val Phe Gly Arg Lys Lys 
    290                 295                 300                 


Glu Trp Ile Tyr Thr Arg Ser Glu Ile Leu Tyr Asp Tyr Thr Tyr Thr 
305                 310                 315                 320 


Ser Val Tyr Phe Ser Val Gly Ser Gly Val Val Val Gly Asp Thr Val 
                325                 330                 335     


Tyr Phe Leu Ile Trp Gly Ser Leu Ser Ser Pro Ile Glu Glu Thr Ala 
            340                 345                 350         


Tyr Cys Phe Ala Pro Asp Cys Ser Asn Tyr Asn Gln Arg Met Cys Asn 
        355                 360                 365             


Glu Ala Gln Arg Pro Ser Lys Phe Gly His Arg Gln Met Val Asn Gly 
    370                 375                 380                 


Ile Leu Lys Phe Lys Thr Thr Ser Thr Gly Lys Pro Leu Leu Ser Val 
385                 390                 395                 400 


Gly Thr Leu Ser Pro Ser Val Val Pro Phe Gly Ser Glu Gly Arg Leu 
                405                 410                 415     


Met Tyr Ser Glu Ile Thr Lys Ile Ile Tyr Leu Tyr Leu Arg Ser Thr 
            420                 425                 430         


Ser Trp His Ala Leu Pro Leu Thr Gly Leu Phe Val Leu Gly Pro Pro 
        435                 440                 445             


Thr Ser Ile Ser Trp Ile Val Gln Arg Ala Val Ser Arg Pro Gly Glu 
    450                 455                 460                 


Phe Pro Cys Gly Ala Ser Asn Arg Cys Pro Lys Asp Cys Val Thr Gly 
465                 470                 475                 480 


Val Tyr Thr Asp Leu Phe Pro Leu Gly Ser Arg Tyr Glu Tyr Ala Ala 
                485                 490                 495     


Thr Val Tyr Leu Asn Ser Glu Thr Tyr Arg Val Asn Pro Thr Leu Ala 
            500                 505                 510         


Leu Ile Asn Gln Thr Asn Ile Ile Ala Ser Lys Lys Val Thr Thr Glu 
        515                 520                 525             


Ser Gln Arg Ala Gly Tyr Thr Thr Thr Thr Cys Phe Val Phe Lys Leu 
    530                 535                 540                 


Arg Val Trp Cys Ile Ser Val Val Glu Leu Ala Pro Ser Thr Met Thr 
545                 550                 555                 560 


Ala Tyr Glu Pro Ile Pro Phe Leu Tyr Gln Leu Asp Leu Thr Cys Lys 
                565                 570                 575     


Gly Lys Asn Gly Ser Leu Ala Met Arg Phe Ala Gly Lys Glu Gly Thr 
            580                 585                 590         


Tyr Lys Ser Gly Arg Tyr Lys Ser Pro Arg Asn Glu Cys Phe Phe Glu 
        595                 600                 605             


Lys Val Ser Asn Lys Tyr Tyr Phe Ile Val Ser Thr Pro Glu Gly Ile 
    610                 615                 620                 


Gln Pro Tyr Glu Ile Arg Asp Leu Thr Pro Asp Arg Met Pro His Ile 
625                 630                 635                 640 


Ile Met Tyr Ile Ser Asp Val Cys Ala Pro Ala Leu Ser Ala Phe Lys 
                645                 650                 655     


Lys Leu Leu Pro Ala Met Arg Pro Ile Thr Thr Leu Thr Ile Gly Asn 
            660                 665                 670         


Trp Gln Phe Arg Pro Val Glu Val Ser Gly Gly Leu Arg Val Asn Ile 
        675                 680                 685             


Gly Arg Asn Leu Thr Lys Glu Gly Asp Leu Thr Met Ser Ala Pro Glu 
    690                 695                 700                 


Asp Pro Gly Ser Asn Thr Phe Pro Gly Asn His Ile Pro Gly Asn Gly 
705                 710                 715                 720 


Ile Leu Asp Ala Gly Tyr Tyr Thr Val Glu Tyr Pro Lys Glu 
                725                 730                 


<210>  364
<211>  544
<212>  PRT
<213>  Jun jeilongvirus

<400>  364

Met Lys Pro Val Ala Leu Ile Tyr Leu Thr Ile Leu Ala Phe Thr Val 
1               5                   10                  15      


Lys Val Arg Ser Gln Leu Ala Leu Ser Asp Leu Thr Lys Ile Gly Ile 
            20                  25                  30          


Ile Pro Ala Lys Ser Tyr Glu Leu Lys Ile Ser Thr Gln Ala Ala Gln 
        35                  40                  45              


Gln Leu Met Val Ile Lys Leu Ile Pro Asn Val Asn Gly Leu Thr Asn 
    50                  55                  60                  


Cys Thr Ile Pro Val Met Asp Ser Tyr Lys Lys Met Leu Asp Arg Ile 
65                  70                  75                  80  


Leu Lys Pro Ile Asp Asp Ala Leu Asn His Val Lys Asn Ala Ile Gln 
                85                  90                  95      


Asp Lys Gln Gly Asp Gly Val Pro Gly Val Arg Phe Trp Gly Ala Ile 
            100                 105                 110         


Ile Gly Gly Val Ala Leu Gly Val Ala Thr Ser Ala Gln Ile Thr Ala 
        115                 120                 125             


Gly Val Ala Leu His Asn Ser Ile Gln Asn Ala Asn Ala Ile Leu Gln 
    130                 135                 140                 


Leu Lys Glu Ser Ile Arg Asn Ser Asn Lys Ala Ile Glu Glu Leu Gln 
145                 150                 155                 160 


Ala Gly Leu Gln Ser Thr Val Leu Val Ile Asn Ala Leu Gln Asp Gln 
                165                 170                 175     


Ile Asn Ser Gln Leu Val Pro Ala Ile Asn Thr Leu Gly Cys Ser Val 
            180                 185                 190         


Ile Ala Asn Thr Leu Gly Leu Arg Leu Asn Gln Tyr Phe Ser Glu Ile 
        195                 200                 205             


Ser Leu Val Phe Gly Pro Asn Leu Arg Asp Pro Thr Ser Gln Thr Leu 
    210                 215                 220                 


Ser Ile Gln Ala Ile Ala Lys Ala Phe Asn Gly Asp Phe Asp Ser Met 
225                 230                 235                 240 


Met Lys Lys Met His Tyr Thr Asp Ser Asp Phe Leu Asp Leu Leu Glu 
                245                 250                 255     


Ser Asp Ser Ile Arg Gly Arg Ile Ile Ser Val Ser Leu Glu Asp Tyr 
            260                 265                 270         


Leu Ile Ile Ile Gln Ile Asp Tyr Pro Gly Leu Thr Thr Ile Pro Asn 
        275                 280                 285             


Ser Val Val Gln Thr Phe Asn Leu Ile Thr Tyr Asn Tyr Lys Gly Thr 
    290                 295                 300                 


Glu Trp Glu Ser Ile Phe Pro Arg Glu Leu Leu Ile Arg Gly Ser Tyr 
305                 310                 315                 320 


Ile Ser Asn Ile Asp Ile Ser Gln Cys Val Gly Thr Ser Lys Ser Met 
                325                 330                 335     


Ile Cys Lys Ser Asp Thr Ser Thr Thr Ile Ser Pro Ala Thr Trp Ala 
            340                 345                 350         


Cys Ala Thr Gly Asn Leu Thr Ser Cys Ala Arg Thr Arg Val Val Asn 
        355                 360                 365             


Ser His Ser Thr Arg Phe Ala Leu Ser Gly Gly Val Leu Phe Ala Asn 
    370                 375                 380                 


Cys Ala Pro Ile Ala Cys Arg Cys Gln Asp Pro Gln Tyr Ser Ile Asn 
385                 390                 395                 400 


Gln Glu Pro Lys Thr Thr Asn Val Met Val Thr Ser Glu Asp Cys Lys 
                405                 410                 415     


Glu Leu Tyr Ile Asp Gly Phe Tyr Leu Thr Leu Gly Lys Lys Met Leu 
            420                 425                 430         


Asp Arg Ala Met Tyr Ala Glu Asp Val Ala Leu Gly Gly Ser Val Ser 
        435                 440                 445             


Val Asp Pro Ile Asp Ile Gly Asn Glu Leu Asn Ser Ile Asn Glu Ser 
    450                 455                 460                 


Ile Asn Lys Ser His Glu Tyr Leu Asp Lys Ala Asn Glu Leu Leu Glu 
465                 470                 475                 480 


Gln Val Asn Pro Asn Ile Val Asn Val Ser Ser Phe Ser Phe Ile Leu 
                485                 490                 495     


Val Ile Ser Ile Leu Leu Ile Ile Trp Phe Ile Val Thr Leu Val Trp 
            500                 505                 510         


Leu Ile Tyr Leu Thr Lys His Met Asn Phe Ile Val Gly Lys Val Ala 
        515                 520                 525             


Met Gly Ser Arg Ser Ser Thr Val Asn Ser Leu Ser Gly Phe Val Gly 
    530                 535                 540                 


<210>  365
<211>  709
<212>  PRT
<213>  Jun jeilongvirus

<400>  365

Met Asn Pro Val Ala Met Ser Asn Phe Tyr Gly Ile Asn Gln Ala Asp 
1               5                   10                  15      


His Leu Arg Glu Lys Gly Asp Gln Pro Glu Lys Gly Pro Ser Val Leu 
            20                  25                  30          


Thr Tyr Val Ser Leu Ile Thr Gly Leu Leu Ser Leu Phe Thr Ile Ile 
        35                  40                  45              


Ala Leu Asn Val Thr Asn Ile Ile Tyr Leu Thr Gly Ser Gly Gly Thr 
    50                  55                  60                  


Met Ala Thr Ile Lys Asp Asn Gln Gln Ser Met Ser Gly Ser Met Arg 
65                  70                  75                  80  


Asp Ile Ser Gly Met Leu Val Glu Asp Leu Lys Pro Lys Thr Asp Leu 
                85                  90                  95      


Ile Asn Ser Met Val Ser Tyr Thr Ile Pro Ser Gln Ile Ser Ala Met 
            100                 105                 110         


Ser Ala Met Ile Lys Asn Glu Val Leu Arg Gln Cys Thr Pro Ser Phe 
        115                 120                 125             


Met Phe Asn Asn Thr Ile Cys Pro Ile Ala Glu His Pro Val His Thr 
    130                 135                 140                 


Ser Tyr Phe Glu Glu Val Gly Ile Glu Ala Ile Ser Met Cys Thr Gly 
145                 150                 155                 160 


Thr Asn Arg Lys Leu Val Val Asn Gln Gly Ile Asn Phe Val Glu Tyr 
                165                 170                 175     


Pro Ser Phe Ile Pro Gly Ser Thr Lys Pro Gly Gly Cys Val Arg Leu 
            180                 185                 190         


Pro Ser Phe Ser Leu Gly Leu Glu Val Phe Ala Tyr Ala His Ala Ile 
        195                 200                 205             


Thr Gln Asp Asp Cys Thr Ser Ser Ser Thr Pro Asp Tyr Tyr Phe Ser 
    210                 215                 220                 


Val Gly Arg Ile Ala Asp His Gly Thr Asp Val Pro Val Phe Glu Thr 
225                 230                 235                 240 


Leu Ala Glu Trp Phe Leu Asp Asp Lys Met Asn Arg Arg Ser Cys Ser 
                245                 250                 255     


Val Thr Ala Ala Gly Lys Gly Gly Trp Leu Gly Cys Ser Ile Leu Val 
            260                 265                 270         


Gly Ser Phe Thr Asp Glu Leu Thr Ser Pro Glu Val Asn Arg Ile Ser 
        275                 280                 285             


Leu Ser Tyr Met Asp Thr Phe Gly Lys Lys Lys Asp Trp Leu Tyr Thr 
    290                 295                 300                 


Gly Ser Glu Val Arg Ala Asp Gln Ser Trp Ser Ala Leu Phe Phe Ser 
305                 310                 315                 320 


Val Gly Ser Gly Val Val Ile Gly Asp Thr Val Tyr Phe Leu Val Trp 
                325                 330                 335     


Gly Gly Leu Asn His Pro Ile Asn Val Asp Ala Met Cys Arg Ala Pro 
            340                 345                 350         


Gly Cys Gln Ser Pro Thr Gln Ser Leu Cys Asn Tyr Ala Ile Lys Pro 
        355                 360                 365             


Gln Glu Trp Gly Gly Asn Gln Ile Val Asn Gly Ile Leu His Phe Lys 
    370                 375                 380                 


His Asp Thr Asn Glu Lys Pro Thr Leu His Val Arg Thr Leu Ser Pro 
385                 390                 395                 400 


Asp Asn Asn Trp Met Gly Ala Glu Gly Arg Leu Phe His Phe His Asn 
                405                 410                 415     


Ser Gly Lys Thr Phe Ile Tyr Thr Arg Ser Ser Thr Trp His Thr Leu 
            420                 425                 430         


Pro Gln Val Gly Ile Leu Thr Leu Gly Trp Pro Leu Ser Val Gln Trp 
        435                 440                 445             


Val Asp Ile Thr Ser Ile Ser Arg Pro Gly Gln Ser Pro Cys Glu Tyr 
    450                 455                 460                 


Asp Asn Arg Cys Pro His Gln Cys Val Thr Gly Val Tyr Thr Asp Leu 
465                 470                 475                 480 


Phe Pro Leu Gly Val Ser Tyr Glu Tyr Ser Val Thr Ala Tyr Leu Asp 
                485                 490                 495     


Gln Val Gln Ser Arg Met Asn Pro Lys Ile Ala Leu Val Gly Ala Gln 
            500                 505                 510         


Glu Lys Ile Tyr Glu Lys Thr Ile Thr Thr Asn Thr Gln His Ala Asp 
        515                 520                 525             


Tyr Thr Thr Thr Ser Cys Phe Ala Tyr Lys Leu Arg Val Trp Cys Val 
    530                 535                 540                 


Ser Ile Val Glu Met Ser Pro Gly Val Ile Thr Thr Arg Gln Pro Val 
545                 550                 555                 560 


Pro Phe Leu Tyr His Leu Asn Leu Gly Cys Gln Asp Thr Ser Thr Gly 
                565                 570                 575     


Ser Leu Thr Pro Leu Asp Ala His Gly Gly Thr Tyr Leu Asn Thr Asp 
            580                 585                 590         


Pro Val Gly Asn Lys Val Asp Cys Tyr Phe Val Leu His Glu Gly Gln 
        595                 600                 605             


Ile Tyr Phe Gly Met Ser Val Gly Pro Ile Asn Tyr Thr Tyr Ser Ile 
    610                 615                 620                 


Val Gly Arg Ser Arg Glu Ile Gly Ala Asn Met Asn Val Ser Leu Asn 
625                 630                 635                 640 


Gln Leu Cys His Ser Val Tyr Thr Glu Phe Leu Lys Glu Lys Glu His 
                645                 650                 655     


Pro Gly Thr Arg Asn Asn Ile Asp Val Glu Gly Trp Leu Leu Lys Arg 
            660                 665                 670         


Ile Glu Thr Leu Asn Gly Thr Lys Ile Phe Gly Leu Asp Asp Leu Glu 
        675                 680                 685             


Gly Ser Gly Pro Gly His Gln Ser Gly Pro Glu Asp Pro Ser Ile Ala 
    690                 695                 700                 


Pro Ile Gly His Asn 
705                 


<210>  366
<211>  546
<212>  PRT
<213>  Lophuromys jeilongvirus 1

<400>  366

Met Lys His Arg Arg Asp Met Leu Met Thr Lys Ala Leu Leu Ile Ile 
1               5                   10                  15      


Ile Ile Leu Ile Gly Pro Leu Ser Ser Gln Ile Ser Phe Thr Asn Leu 
            20                  25                  30          


Ser Lys Ile Gly Val Ile Lys Gly Lys Asn Tyr Lys Leu Lys Ile Thr 
        35                  40                  45              


Ser Asn Pro Thr Tyr Gln Phe Met Val Leu Lys Met Ile Pro Asn Val 
    50                  55                  60                  


Val Asn Met Ser Gln Cys Gly Gln Asp His Leu Asp Asn Tyr Lys Gly 
65                  70                  75                  80  


Met Leu Lys Arg Ile Leu Gln Pro Ile Ser Asp Ser Ile Asn Leu Met 
                85                  90                  95      


Arg Ser Val Ile Gln Asp Lys Pro Asn Asn Gly Arg Phe Trp Gly Ala 
            100                 105                 110         


Leu Val Gly Gly Val Ala Leu Gly Val Ala Thr Ser Ala Gln Val Thr 
        115                 120                 125             


Ala Gly Val Ala Leu His Asn Ser Leu Glu Asn Ala Arg Ala Ile Leu 
    130                 135                 140                 


Gln Leu Lys Asp Ala Ile Gln Ala Thr Asn Gln Ala Val Gln Glu Val 
145                 150                 155                 160 


Ile Ser Ala Gln Arg Lys Ser Val Leu Val Ile Asn Ala Leu Gln Asp 
                165                 170                 175     


Gln Ile Asn Gly Asn Ile Val Pro Ala Ile Lys Ser Leu Gly Cys Lys 
            180                 185                 190         


Val Ala Gly Asn Thr Phe Gly Leu Arg Leu Thr Gln Tyr Phe Ser Glu 
        195                 200                 205             


Val Ser Leu Val Phe Gly Pro Asn Leu Arg Asp Pro Ala Ala Glu Thr 
    210                 215                 220                 


Leu Ser Ile Gln Ala Ile Ser Arg Ala Phe Asn Gly Asp Phe Asp Ser 
225                 230                 235                 240 


Leu Leu Lys Ala Leu Gly Tyr Lys Glu Ser Asp Leu Met Asp Val Leu 
                245                 250                 255     


Glu Ser Gly Ser Ile Arg Gly Arg Ile Ile Asp Val Ser Leu Asp Asn 
            260                 265                 270         


Tyr Phe Leu Ile Ile Gln Ile Glu Tyr Pro Thr Leu Val Asn Ile Pro 
        275                 280                 285             


Asp Ala Thr Val Gln Lys Phe Asn Leu Ile Ser Tyr Asn Tyr Asp Gly 
    290                 295                 300                 


Ser Glu Trp Leu Ser Val Phe Pro Lys Ala Leu Leu Lys Arg Gly Ser 
305                 310                 315                 320 


Tyr Leu Ser Asn Ile Asp Leu Ser Asp Cys Thr Gln Thr Thr Asn Thr 
                325                 330                 335     


Ile Leu Cys Pro Gln Asp Thr Ser Ser Pro Leu Thr Gln Asn Leu Tyr 
            340                 345                 350         


Asp Cys Ala Thr Gly Lys Ile Ser Gln Cys Ala Arg Met Arg Val Val 
        355                 360                 365             


Asn Ser His Val Ser Arg Tyr Ala Leu Ser Asp Gly Val Leu Phe Leu 
    370                 375                 380                 


Asn Cys Ile Pro Ile Asn Cys Arg Cys Ser Asp Pro Glu Tyr Ala Ile 
385                 390                 395                 400 


Ile Gln Glu Pro Thr Thr Thr Thr Leu Met Met Ser Tyr Asp Asp Cys 
                405                 410                 415     


Arg Glu Val Met Val Glu Gly Ile Phe Val Thr Val Gly Lys Lys Thr 
            420                 425                 430         


Leu Asn Arg Thr Ser Tyr Thr Gly Glu Val Asp Val Gly Gly Ile Val 
        435                 440                 445             


Thr Leu Asp Pro Ile Asp Ile Ser Thr Asp Val Ala Asp Ile Gln Asp 
    450                 455                 460                 


Thr Leu Asp Lys Ala Gln Glu Glu Ile Asp Lys Ser Asn Glu Ile Leu 
465                 470                 475                 480 


Ser Lys Val Asn Pro Asn Ile Ile Thr Leu Gly Gly Phe Val Ser Ile 
                485                 490                 495     


Ile Ser Phe Thr Thr Leu Phe Gly Ile Tyr Cys Val Val Ser Leu Ile 
            500                 505                 510         


Trp Leu Ile Cys Leu Thr Lys Arg Thr Ser Arg Pro Tyr Ala Met Met 
        515                 520                 525             


Thr Phe Arg Asn Arg Ser Pro Thr Ile Thr Thr Leu Ser Ser Asn Met 
    530                 535                 540                 


Thr Ser 
545     


<210>  367
<211>  854
<212>  PRT
<213>  Lophuromys jeilongvirus 1

<400>  367

Met Ala Asp Tyr Tyr Lys Thr Gly Gly Ile Ile Thr Pro Val Lys Lys 
1               5                   10                  15      


Pro Thr Glu Glu Glu Arg Asn His Lys Ser Asn Val Leu Ala Tyr Thr 
            20                  25                  30          


Ser Leu Ile Leu Gly Ile Leu Ser Val Ile Val Leu Ile Leu Leu Asn 
        35                  40                  45              


Ile Thr Asn Ile Thr Met Thr Ile Lys Lys Asp Ser Ile Asn Gly Ala 
    50                  55                  60                  


Leu Asn Ser Lys Pro Ile Met Thr Glu Thr Gln Gly Asn Lys Ile Ser 
65                  70                  75                  80  


Asp Leu Ile Glu Ser Asp Leu Ile Pro Lys Thr Asn Leu Ile Asn Asn 
                85                  90                  95      


Met Val Ser Tyr Gln Ile Pro Thr Ser Leu Thr Gln Ile Tyr Ser Leu 
            100                 105                 110         


Ile Lys Arg Asp Val Leu Gln Ala Cys Thr Pro Lys Phe Asp His Glu 
        115                 120                 125             


Gly Ser Gln Cys Pro Val Asn Ser Asn Pro Phe His Ser Gly Ser Phe 
    130                 135                 140                 


Ser Leu Ile Asn Arg Asn Thr Phe Ser Arg Cys Pro Asp Pro Asn Asn 
145                 150                 155                 160 


Asn Leu Gly Met Arg Glu Ser Ile Lys Leu Met Asp Tyr Pro Ser Phe 
                165                 170                 175     


Ile Pro Gly Pro Thr Arg Pro Gly Gly Cys Ser Arg Asp Pro Ser Phe 
            180                 185                 190         


Asp Leu Gly Asn Lys Ile Phe Ala Tyr Thr His Asn Val Val Pro Gln 
        195                 200                 205             


Gly Cys Gly Tyr Thr Glu Met Thr Met Gln Tyr Phe Asn Ile Gly Arg 
    210                 215                 220                 


Val Thr Asp Val Asn Ala Asp Met Pro Phe Phe Glu Ile Leu Thr Gln 
225                 230                 235                 240 


Trp Tyr Leu Asp Asp Gly Leu Asn Arg Lys Ser Cys Thr Val Val Thr 
                245                 250                 255     


Ser Asp Glu Gly Ala Trp Ile Leu Cys Ile Val Thr Ser Glu Ser Glu 
            260                 265                 270         


Glu Lys Asp Tyr Ala Asp Gln Gly Ile Gly Arg Val Phe Ile Gly Tyr 
        275                 280                 285             


Met Asp Ile Tyr Gly Arg Lys Lys Ser Trp Tyr Leu Asp Glu Pro Glu 
    290                 295                 300                 


Ile Gln Phe Asp Leu Pro Met Ala Ala Met Tyr Phe Ser Gly Gly Ser 
305                 310                 315                 320 


Gly Val Ser Asp Glu Gly Lys Ile Tyr Val Leu Ile Tyr Gly Gly Leu 
                325                 330                 335     


Met Thr Ala Val Ser Gly Asp Val Phe Cys Asp Ala Pro Gly Cys Asp 
            340                 345                 350         


Asn Pro Ser Gln Asp Met Cys Lys Lys Ala Ser Met Pro Lys Ser Arg 
        355                 360                 365             


Ser Gln Arg Gln Met Val Asn Gly Leu Phe Ile Phe Asp Asp Asn Pro 
    370                 375                 380                 


Leu Glu Ala Pro Lys Pro Ile Val Lys Leu Ile Pro Pro Ser Gln Asn 
385                 390                 395                 400 


Trp Val Gly Ser Arg Gly Arg Leu Tyr Lys Ser Asp Tyr Pro Lys Ile 
                405                 410                 415     


Phe Phe Leu Tyr Ile Ser Ser Asp Ser Trp His Ser Leu Pro Lys Ile 
            420                 425                 430         


Gly Ile Ile Ala Val Gly Asp Gln Thr Tyr Leu His Trp Val Glu Asn 
        435                 440                 445             


Val Ala Val Ser Arg Pro Gly Pro Glu Asn Cys Met Tyr Gly Asn Arg 
    450                 455                 460                 


Cys Pro Gln Glu Cys Leu Gly Ala Pro Tyr Thr Asp Ile Phe Pro Leu 
465                 470                 475                 480 


Asp Ser Asn Phe Glu Ile Gly Ile Ser Val Thr Leu Lys Ser Tyr Gln 
                485                 490                 495     


Val Asn Lys Asn Pro Val Ile Thr Leu Val Thr Gln Asn Lys Ile Ile 
            500                 505                 510         


Ser Glu Thr Glu Val Thr Asn Asp His His Gly Ala Gln Tyr Thr Thr 
        515                 520                 525             


Thr Ser Cys Phe Lys Tyr Ala Arg Ser Leu Trp Cys Leu Ser Ile Val 
    530                 535                 540                 


Ala Phe Glu Pro Ala Thr Val Gly Glu Arg Ala Pro Val Pro Leu Leu 
545                 550                 555                 560 


Tyr Lys Val Pro Val Tyr Cys Lys Ala Ser Gly Thr Arg Leu Thr Ile 
                565                 570                 575     


Pro Ile Pro Tyr Phe Ser Asn Gly Ser Arg Pro Ile Val Val Leu Thr 
            580                 585                 590         


Asn Glu Leu Tyr Pro Pro Glu Val Pro Lys Phe Gln Thr Gln Asp Asp 
        595                 600                 605             


Phe Asn Lys Leu Gln Leu Ser Pro Tyr His Phe Glu Arg Pro Gly Thr 
    610                 615                 620                 


Thr Gly Pro Pro Ser Thr Thr Ser Lys Leu Gln Thr Thr Arg Ser Leu 
625                 630                 635                 640 


His Val Asp Thr Ser Thr Gln Val Ile Lys Gln Val Thr Pro Thr Thr 
                645                 650                 655     


Leu Ser Glu Pro Thr Thr Arg Glu Gln Thr Pro Thr Thr Ala Asn Thr 
            660                 665                 670         


Leu Ser Thr Lys Glu Met Leu Thr Thr Val Lys Thr Ile Asp Glu Asn 
        675                 680                 685             


Thr Thr Arg Ile Thr Ala Gln His His Asp Thr Thr Gln Arg Ser Thr 
    690                 695                 700                 


Ile Thr Thr Leu Asn Lys Thr Ala Gln Thr Thr Glu Gly Thr Gly Gln 
705                 710                 715                 720 


His Gln Ile Thr Thr His Asn Ile Thr Arg Arg Asp Thr Thr Pro Asn 
                725                 730                 735     


Thr Asp Gly His Ser Ile Ser Thr Ala Arg Gln Pro Asn Ile Gln Ser 
            740                 745                 750         


His Thr Ala Lys Asp Glu Asn Thr Pro Asp Ile Tyr Asn Asn Val Arg 
        755                 760                 765             


Arg Ile Gly Ile Gln Arg Glu Thr Lys Thr Ser Arg Ser Arg Asp Arg 
    770                 775                 780                 


Arg Pro Lys Lys Gln Lys Leu Asp Asp Tyr Ala Ser Lys Asp Gln His 
785                 790                 795                 800 


Asn Thr Phe Glu Asp Gln Gly Leu Trp Asp Lys Ile Ser Ser Tyr Leu 
                805                 810                 815     


Leu Pro Ile Gln Ser Asp Tyr Tyr Gly Ile Glu Asp Pro Glu Leu Asp 
            820                 825                 830         


Ser Ile Asp Leu Phe Asp Tyr Arg His Val Thr Ser Ser Ser His Asn 
        835                 840                 845             


Arg Val Met Ile Tyr Gln 
    850                 


<210>  368
<211>  549
<212>  PRT
<213>  Lophuromys jeilongvirus 2

<400>  368

Met Thr Lys Leu Tyr Tyr Ile Ser Ile Ile Ile Val Val Ile Ala Ile 
1               5                   10                  15      


Asn Leu His Tyr Ile Glu Ala Gln Ile Ser Leu Ala Glu Leu Ser Lys 
            20                  25                  30          


Ile Gly Ile Ile Gln Gly Asn Asn Tyr Gly Leu Lys Val Ser Gly Val 
        35                  40                  45              


Ser Thr Tyr Gln Leu Met Val Ile Lys Leu Ile Pro Asn Val Ser Gln 
    50                  55                  60                  


Leu Ser Asn Cys Thr Thr Asp Val Met Val Ser Tyr Lys Gly Met Leu 
65                  70                  75                  80  


Asp Arg Ile Leu Asn Pro Ile Asn Ser Ser Leu Ala Lys Val Arg Ala 
                85                  90                  95      


Ala Ile Lys Asp Lys Val Asp Tyr Thr Pro Ser Arg Asn Gly Glu Arg 
            100                 105                 110         


Phe Trp Gly Ala Ile Val Gly Gly Val Ala Leu Gly Val Ala Thr Ala 
        115                 120                 125             


Ala Gln Val Thr Ala Gly Val Ala Leu His Asn Ser Leu Glu Asn Ala 
    130                 135                 140                 


Lys Ala Ile Met Gln Leu Lys Asp Ala Ile Arg Asn Ser Asn Ala Ala 
145                 150                 155                 160 


Ile Gln Glu Leu Thr Thr Ser Gln Gly Gln Val Val Val Ala Ile Asn 
                165                 170                 175     


Ala Leu Gln Glu Gln Ile Asn Thr Gln Leu Val Pro Ser Leu Asn Gln 
            180                 185                 190         


Leu Gly Cys Ser Val Ile Gly Asn Thr Leu Gly Leu Lys Leu Asn Gln 
        195                 200                 205             


Tyr Phe Ser Glu Leu Ser Leu Ile Phe Gly Pro Asn Leu Arg Asp Pro 
    210                 215                 220                 


Thr Ser Glu Thr Leu Ser Ile Gln Ala Ile Ala Arg Ala Phe Asn Gly 
225                 230                 235                 240 


Asp Phe Asp Thr Met Leu Asn Lys Leu Lys Tyr Asp Thr Ser Asp Phe 
                245                 250                 255     


Leu Asp Leu Leu Glu Ser Gly Gly Ile Arg Gly Arg Ile Ile Asp Val 
            260                 265                 270         


Ser Leu Thr Asp Tyr Ile Ile Ser Leu Gln Ile Glu Tyr Pro Thr Leu 
        275                 280                 285             


Thr Ala Ile Pro Asp Ala Thr Val Gln Leu Phe Asn Leu Ile Ser Tyr 
    290                 295                 300                 


Asn His Arg Gly Ser Glu Trp Met Ser Val Phe Pro Arg Gln Met Leu 
305                 310                 315                 320 


Ile Arg Gly Ser Tyr Leu Ser Asn Ile Asp Leu Ser Glu Cys Val Gln 
                325                 330                 335     


Thr Ser Ser Asn Tyr Ile Cys Ser Thr Asp Thr Ser Ser Ala Leu Ser 
            340                 345                 350         


Ser Gly Thr Tyr Glu Cys Ala Thr Gly Asn Ile Thr Ser Cys Ala Arg 
        355                 360                 365             


Thr Arg Val Val Asn Ser His Val Ser Arg Phe Ala Leu Ser Lys Gly 
    370                 375                 380                 


Val Leu Phe Val Asn Cys Ala Ser Ile Val Cys Arg Cys Gln Asp Pro 
385                 390                 395                 400 


Lys Tyr Thr Ile Ile Gln Asp Thr Gln Val Thr Asn Val Met Ile Ser 
                405                 410                 415     


Ser Gln Asp Cys Lys Glu Val Tyr Ile Asp Gly Tyr Phe Ile Thr Leu 
            420                 425                 430         


Gly Pro Lys Thr Leu Glu Arg Ser Met Tyr Ser Asp Asn Val Thr Leu 
        435                 440                 445             


Gly Gly Thr Val Ser Val Glu Ile Ile Asp Ile Gly Asn Glu Leu Asn 
    450                 455                 460                 


Ser Ile Gln Glu Ser Leu Asn Arg Thr Gln His Tyr Ile Asp Lys Ser 
465                 470                 475                 480 


Asn Glu Ile Leu Asp Arg Val Asn Pro Asn Val Ile Asn Leu Gly Thr 
                485                 490                 495     


Ile Gly Gly Ile Met Phe Leu Thr Ile Leu Ala Thr Ile Trp Phe Ile 
            500                 505                 510         


Ile Ser Leu Ile Trp Leu Ile Cys Leu Thr Arg Lys Ile Met Ile Pro 
        515                 520                 525             


Arg Ser Asn Leu Thr Thr Ser Ser Arg Ser Ser Thr Val Asn Ser Leu 
    530                 535                 540                 


Ala Gly Phe Ile Asn 
545                 


<210>  369
<211>  810
<212>  PRT
<213>  Lophuromys jeilongvirus 2

<400>  369

Met Ile Met Asn Pro Ile Asn Thr Gln Met Thr Asn Tyr Tyr Gly Val 
1               5                   10                  15      


Gly Gly Asn Lys Asp Arg Glu Ala Ile Gln Thr Ser Ser Thr Asn Ser 
            20                  25                  30          


Thr Cys His Ser Ala Leu Thr Tyr Thr Ser Met Ile Val Gly Leu Leu 
        35                  40                  45              


Ser Leu Phe Thr Leu Ile Ala Leu Asn Val Thr Asn Ile Thr Tyr Leu 
    50                  55                  60                  


Ile Gly Ser Gly Gly Ser Met Asn Ala Ile Lys Glu Lys Gln Glu Ser 
65                  70                  75                  80  


Leu Gly Ala Leu Val Arg Asp Ser Val Ser Leu Thr Thr Glu Glu Ile 
                85                  90                  95      


Lys Pro Lys Val Asp Leu Ile Asn Asn Ile Val Ser Tyr Ser Ile Pro 
            100                 105                 110         


Ser Gln Leu Thr Gln Ile Gln His Thr Ile Lys Asn Glu Val Leu Arg 
        115                 120                 125             


Gln Cys Gly Pro Ser Phe Val Tyr Asn Asn Thr Val Cys Pro Val Val 
    130                 135                 140                 


Glu Asn Pro Ser His Ser Gln His Phe Lys Met Ile Asn Pro Tyr Thr 
145                 150                 155                 160 


Ile Ser Glu Cys Ala Asn Thr Gly Ser Phe Ile Gln Val Lys Ser His 
                165                 170                 175     


Ile Ser Phe Ile Asp Tyr Pro Ser Phe Ile Pro Gly Ser Thr Arg Lys 
            180                 185                 190         


Gly Gly Cys Val Arg Ile Pro Ser Phe Ser Leu Ser Asp Thr Ile Phe 
        195                 200                 205             


Ala Tyr Ala His Asn Ile Ile Ala Gln Gly Cys Gln Asp Ser Ser Gln 
    210                 215                 220                 


Ser Asp Gln Tyr Leu Ser Ile Gly Arg Ile Glu Asp His Gly Thr Asp 
225                 230                 235                 240 


Ile Pro Val Ile Glu Thr Ile Ala Glu Trp Tyr Leu Asn Asp Gly Leu 
                245                 250                 255     


Asn Arg Lys Ser Cys Ser Val Ala Ser Gly Asp Thr Tyr Ala Ile Met 
            260                 265                 270         


Gly Cys Thr Ile Val Thr Ser Asp Glu Arg Thr Asp Tyr Leu Asn Pro 
        275                 280                 285             


Gly Ile Gly Arg Leu Ser Ile Thr Tyr Leu Asp Val Phe Gly Arg Lys 
    290                 295                 300                 


Lys Glu Trp Ile Phe Thr Gln Glu Glu Ile Glu Leu Asp Arg Glu Tyr 
305                 310                 315                 320 


Leu Ala Leu Tyr Phe Ser Val Gly Ser Gly Val Ile Ile Asp Asp Glu 
                325                 330                 335     


Ile Tyr Phe Leu Val Tyr Gly Asp Leu Ala Glu Pro Met Pro Gly Asn 
            340                 345                 350         


Val Phe Cys His Ala Pro Gly Cys Ala Ala Val Asn Gln Asp Val Cys 
        355                 360                 365             


Asn Ala Ala Thr Lys Pro Asn Trp Phe Gly Arg His Gln Ile Val Asn 
    370                 375                 380                 


Gly Ile Leu Ser Phe Thr Ala Asp Phe Glu Ser Arg Pro Arg Leu Arg 
385                 390                 395                 400 


Val Arg Thr Ile Pro Pro Ser Lys Thr Trp Leu Gly Ala Glu Gly Arg 
                405                 410                 415     


Leu Met Tyr Ser Thr Val Ala Arg Lys Thr Tyr Ile Tyr Val Arg Ser 
            420                 425                 430         


Thr Gly Trp His Ala Leu Ala Gln Thr Gly Ile Ile Asp Leu Thr Gly 
        435                 440                 445             


Asp Leu Ser Ile Gln Trp Val Asp Gln Leu Val Leu Ser Arg Pro Gly 
    450                 455                 460                 


Thr Ser Gly Cys Pro Ala Ala Asn Arg Cys Pro Lys Glu Cys Val Thr 
465                 470                 475                 480 


Gly Val Tyr Thr Asp Ala Phe Pro Leu Gly Val Asn Tyr Asp Val Ser 
                485                 490                 495     


Val Ser Val Val Leu Ala Thr Gln Ser Thr Arg Ser Asn Pro Arg Leu 
            500                 505                 510         


Met Val Val Asn Gly Thr Asn Ile Ile Tyr Val Lys Thr Val Thr Ser 
        515                 520                 525             


Ala Ser Gln Lys Ala Ser Tyr Thr Thr Thr Thr Cys Phe Val Phe Lys 
    530                 535                 540                 


Met Arg Ile Trp Cys Leu Ser Ile Ile Glu Leu Ser Pro Gly Ala Val 
545                 550                 555                 560 


Gly Glu Phe Val Pro Val Pro Phe Leu Tyr Gln Leu Asn Leu Gly Cys 
                565                 570                 575     


Val Asp Lys Asp Thr Gly Val Thr Glu Gln Leu Ser Ser Tyr Ser Gly 
            580                 585                 590         


Lys Asp Thr Tyr Thr Leu Thr Pro Tyr Glu Thr Pro Lys Thr Glu Cys 
        595                 600                 605             


Tyr Leu Glu Leu Ser Gly Asp Asp Met Tyr Phe Ala Val Lys Val Phe 
    610                 615                 620                 


Gly Asn His Gln Ser Tyr Arg Leu Thr Trp Lys Ala Gln Ala Lys Thr 
625                 630                 635                 640 


Thr Glu Asp Ile Ala Thr Val Ser Gln Leu Cys His Glu Val Leu Lys 
                645                 650                 655     


Tyr Met Thr Asp Arg Gly Asp Val Phe Asn Asn Asn Thr Val Val Asp 
            660                 665                 670         


Thr Glu His Val Thr Leu Thr Pro Val Thr Leu Ser Ala Gly Thr Arg 
        675                 680                 685             


Val Thr Leu Thr Lys Thr Asp Ser Thr Pro Val Ala Asn Glu Thr Thr 
    690                 695                 700                 


Ser Met Ser Thr Ala Ile Lys Ala Thr Leu Asp Arg Thr Thr Arg Ser 
705                 710                 715                 720 


Val Thr Thr Arg Leu Thr Glu Ser Thr Ala Phe Asn His Thr Ser Ser 
                725                 730                 735     


Val Leu Asn Gln Ile Thr Val Thr Pro Thr Ser Ser Thr Thr Glu Ala 
            740                 745                 750         


Asn His Thr Ser Thr Pro Ile Thr Arg Val Ser Gln His Glu Thr Ser 
        755                 760                 765             


Ser Val Val Thr His Gly Gln Leu Asn Asn Thr Leu Asn Ala Thr Gly 
    770                 775                 780                 


Ser Trp Arg Leu Arg Tyr Ser Asn Leu Phe Glu Arg Gly Tyr Ser Glu 
785                 790                 795                 800 


Met Met Lys Trp Trp Gly Asn Asn Gly Asp 
                805                 810 


<210>  370
<211>  544
<212>  PRT
<213>  Myodes jeilongvirus

<400>  370

Met Ser Lys Leu Arg Ala Ala Val Leu Leu Leu Ile Met Ile Pro Ser 
1               5                   10                  15      


Leu Cys Arg Ser Gln Leu Ala Leu Ser Glu Leu Thr Lys Ile Gly Ile 
            20                  25                  30          


Ile Pro Gly Lys Ser Tyr Asp Leu Lys Leu Ser Thr Gln Ser Thr Tyr 
        35                  40                  45              


Gln Tyr Met Val Ile Lys Leu Ile Pro Asn Leu Asn Asn Met Thr Lys 
    50                  55                  60                  


Cys Thr Ile Asp Thr Leu Asp Asn Tyr Lys Asn Met Leu Ser Arg Val 
65                  70                  75                  80  


Leu Asn Pro Ile His Asp Ser Leu Lys Lys Met Lys Asp Ala Val Gln 
                85                  90                  95      


Asp Lys Glu Pro Ala Asn Met Pro Pro Val Lys Phe Trp Gly Ala Val 
            100                 105                 110         


Ile Gly Gly Val Ala Leu Gly Val Ala Thr Ser Ala Gln Ile Thr Ala 
        115                 120                 125             


Gly Val Ala Leu His Asn Ser Ile Gln Asn Ala Asn Ala Ile Leu Gln 
    130                 135                 140                 


Leu Lys Asp Ser Ile Arg Gln Ser Asn Lys Ala Ile Ala Glu Leu Gln 
145                 150                 155                 160 


Thr Ala Ser Arg Thr Thr Val Thr Val Leu Asn Ala Leu Gln Glu Gln 
                165                 170                 175     


Ile Asn Thr Gln Leu Val Pro Ala Ile Asn Asn Leu Gly Cys Gln Val 
            180                 185                 190         


Val Ala Asn Thr Leu Gly Leu Arg Leu Asn Gln Tyr Phe Ser Glu Ile 
        195                 200                 205             


Ser Leu Ile Phe Gly Pro Asn Leu Arg Asp Pro Thr Ser Glu Thr Leu 
    210                 215                 220                 


Ser Ile Gln Ala Leu Ser Lys Ala Phe Asn Gly Asp Phe Asp Ser Met 
225                 230                 235                 240 


Ile Ser Gln Leu Lys Tyr Thr Asp Lys Asp Phe Leu Asp Val Leu Glu 
                245                 250                 255     


Ser Asp Ser Ile Arg Ala Arg Ile Ile Asp Val Ser Leu Glu Asp Tyr 
            260                 265                 270         


Phe Ile Thr Leu Gln Ile Glu Tyr Pro Ser Leu Val Gln Val Ser Asp 
        275                 280                 285             


Ala Val Val Gln Thr Phe Asn Lys Ile Ser Tyr Asn His Arg Gly Ser 
    290                 295                 300                 


Glu Trp Ile Ser Leu Phe Pro Thr Gln Leu Leu Ile Arg Gly Met Tyr 
305                 310                 315                 320 


Ile Ser Asn Ile Asp Ile Ser Met Cys Thr Met Thr Ser Thr Ser Leu 
                325                 330                 335     


Ile Cys Lys Ser Asp Thr Ser Ser Pro Ile Ser Thr Ala Thr Trp Ser 
            340                 345                 350         


Cys Ala Asn Gly Asn Leu Thr Ser Cys Ala Arg Thr Arg Val Val Asn 
        355                 360                 365             


Ala His Ile Pro Arg Phe Ala Leu Ser Arg Gly Val Leu Phe Ala Asn 
    370                 375                 380                 


Cys Ala Pro Ile Val Cys Lys Cys Ser Asp Pro Pro Met Asn Ile Asn 
385                 390                 395                 400 


Gln Glu Pro Lys Met Thr Asn Val Met Val Ser Ser Asp Glu Cys Arg 
                405                 410                 415     


Glu Val Tyr Val Asp Gly Leu Tyr Ile Thr Leu Gly Lys Arg Thr Leu 
            420                 425                 430         


Pro Arg Ser Met Tyr Ala Glu Asp Val Ser Leu Gly Gly Pro Ile Ser 
        435                 440                 445             


Val Asp Pro Ile Asp Ile Gly Asn Glu Leu Asn Ser Ile His Asp Ser 
    450                 455                 460                 


Leu Asn Lys Ser Gln Glu Tyr Leu Asp Glu Ala Asn Ala Leu Leu Asp 
465                 470                 475                 480 


Lys Val Asn Pro Arg Ile Ile Asn Val Gln Thr Phe Gly Val Met Leu 
                485                 490                 495     


Ala Phe Ile Ile Leu Leu Ile Ile Trp Val Ile Ala Thr Ile Ile Trp 
            500                 505                 510         


Leu Ile Tyr Leu Thr Lys Ser Ile His Tyr Leu Asn Arg His Val Ser 
        515                 520                 525             


Leu Ser Ser Arg Gly Ser Thr Val Thr Ser Leu Ser Gly Phe Val Gly 
    530                 535                 540                 


<210>  371
<211>  1589
<212>  PRT
<213>  Myodes jeilongvirus

<400>  371

Met Asn Pro Leu Ala Val His Thr Ala Ala Met Ser Asn Phe Tyr Gly 
1               5                   10                  15      


Val Asn Ala Thr Gln Thr Thr Asp Ala Arg Lys Glu Asn His Ile Gly 
            20                  25                  30          


Gly Gln Asp Val Phe Arg Tyr Thr Ser Met Ile Val Gly Leu Leu Ser 
        35                  40                  45              


Leu Phe Thr Ile Ile Ala Leu Asn Val Thr Asn Ile Ile Tyr Leu Thr 
    50                  55                  60                  


Glu Ser Gly Gly Thr Met Glu Ser Ile Lys Asn Ser Gln Gln Ser Leu 
65                  70                  75                  80  


Ser Gly Ser Met Lys Glu Thr Thr Gly Ile Leu Ile Glu Asp Leu Lys 
                85                  90                  95      


Pro Lys Thr Asp Leu Ile Asn Ser Met Val Gly Tyr Asn Ile Pro Thr 
            100                 105                 110         


Gln Leu Ser Leu Ile Tyr Ser Thr Ile Lys Asn Asp Val Leu Lys Gln 
        115                 120                 125             


Cys Thr Pro Thr Phe Met Phe Asn Asn Thr Ile Cys Pro Val Ala Glu 
    130                 135                 140                 


His Pro Ile His Ser Ser Tyr Phe Glu Glu Ile Asn Leu Ser Ser Phe 
145                 150                 155                 160 


Ala Ala Cys Ala Leu Pro Asn Gly Arg Val Val Met Asn Ser Glu Val 
                165                 170                 175     


Thr Tyr Thr Glu Tyr Pro Ser Phe Ile Pro Gly Ser Thr Ser Pro Gly 
            180                 185                 190         


Ser Cys Val Arg Leu Pro Ser Phe Ser Leu Ser Pro Thr Ile Phe Ala 
        195                 200                 205             


Tyr Ser His Thr Ile Met Gly His Gly Cys Ser Glu Leu Asp Val Gly 
    210                 215                 220                 


Asp His Tyr Phe Ser Leu Gly Arg Ile Ala Asp His Gly His Glu Asn 
225                 230                 235                 240 


Pro Val Phe Glu Thr Ile Thr Glu Trp Phe Ile Asn Asp Lys Val Asn 
                245                 250                 255     


Arg Arg Ser Cys Thr Val Ala Ala Gly Gln Tyr Glu Gly Trp Met Gly 
            260                 265                 270         


Cys Val Ile Met Thr Glu Thr Phe Leu Asp Asp Leu Ser Ser Arg Asp 
        275                 280                 285             


Thr Gly Arg Val Ser Ile Thr Tyr Leu Asp Val Tyr Gly Arg Lys Arg 
    290                 295                 300                 


Glu Trp Ile Tyr Thr Arg Ser Glu Ile Arg Phe Asp Gln Asn Tyr Ala 
305                 310                 315                 320 


Ser Leu Tyr Phe Ser Val Gly Ser Gly Val Val Ile Gly Asp Asn Val 
                325                 330                 335     


His Phe Leu Ile Trp Gly Asn Leu Tyr Phe Pro Ile Glu Glu Pro Ala 
            340                 345                 350         


Phe Cys Thr Ala Pro Gln Cys Arg Thr Phe Asn Gln Gln Gln Cys Asn 
        355                 360                 365             


Gln Ala Gln Arg Pro Glu Ala Phe Gly Gly His Gln Met Val Asn Gly 
    370                 375                 380                 


Ile Leu Ser Phe Lys Thr Thr Thr Arg Gly Lys Pro Val Leu Ser Val 
385                 390                 395                 400 


Arg Thr Phe Ser Pro Lys Leu Ile Pro Leu Gly Thr Glu Gly Arg Leu 
                405                 410                 415     


Ile His Phe Gln Asn Ile Asn Arg Thr Tyr Ile Tyr Leu Arg Ser Thr 
            420                 425                 430         


Gly Trp His Ala Leu Pro Leu Thr Gly Arg Ile Ile Phe Thr Val Pro 
        435                 440                 445             


Leu Asn Ile Glu Trp Ile Gln Gln Thr Ala Val Ser Arg Pro Gly Arg 
    450                 455                 460                 


Ser Pro Cys Gly Ala Ser Ser Arg Cys Pro Gln Gln Cys Val Thr Gly 
465                 470                 475                 480 


Val Tyr Thr Asp Leu Phe Pro Met Gly Pro Asn Tyr Glu Tyr Ser Met 
                485                 490                 495     


Thr Ala Phe Leu Asp Ser Glu Thr Asp Arg Val Asn Pro Thr Leu Ala 
            500                 505                 510         


Phe Ile Asn Thr Gly Ser Ile Ile Tyr Arg Lys Thr Leu Thr Gln Ser 
        515                 520                 525             


Asn Gln Lys Ala Gly Tyr Thr Thr Thr Thr Cys Phe Ile Phe Lys Leu 
    530                 535                 540                 


Arg Ile Trp Cys Leu Ser Ile Val Glu Leu Ser Pro Ser Thr Ile Thr 
545                 550                 555                 560 


Glu Phe Glu Pro Val Pro Phe Leu Tyr Gln Leu Asp Val Gly Cys Arg 
                565                 570                 575     


Met Ser Pro Ser Gly Gln Ile Met Pro Leu Ser Tyr Gly Glu Arg Ser 
            580                 585                 590         


Leu Ser Ile Gly Pro Tyr Lys Pro Ala Arg Lys Glu Cys Tyr Leu Glu 
        595                 600                 605             


Gln Val Gly Asp Gln Tyr Tyr Leu Ile Ile Ser Ile Pro Asn Ser Ile 
    610                 615                 620                 


Gln Ala Tyr Thr Ile Arg Asp Leu Asp Pro Glu Lys Ile Pro His Thr 
625                 630                 635                 640 


Gly Leu Tyr Ile Asn Asp Ile Cys Pro Val Leu Leu Asn Val Tyr Thr 
                645                 650                 655     


Thr Met Ser Ala Thr Ala Arg Met Met Thr Ala Ile Met Val Gly Gln 
            660                 665                 670         


Trp Gln Phe Arg Pro Val Asn Arg Pro Gly Gly Thr Arg Val Asn Leu 
        675                 680                 685             


Pro Asn Lys Leu Ala Asn Ala Thr Arg Asn Glu Met Tyr Ser Pro Glu 
    690                 695                 700                 


Asp Pro Gly His Ser Tyr Tyr Val Asp Arg Leu Ile Asp Gln Tyr Asn 
705                 710                 715                 720 


Tyr Gln Thr Leu Pro Glu Gly Ala Leu Val Glu Ile Cys Leu Lys Leu 
                725                 730                 735     


Asn Arg Gly Asn Asn Leu Thr Ile Ile Gln Asp Ile Gln Cys Arg Val 
            740                 745                 750         


Tyr Lys Tyr Ser Arg Val Lys Ser Asn Trp Ser Ile Gly Pro Thr Ser 
        755                 760                 765             


Ser Pro Thr Gly Ile Thr Met Arg Asp Met Ile Thr Gln Leu Asn Lys 
    770                 775                 780                 


Phe Ser Thr Ala Phe Ser Pro Pro Leu Gln Cys Asn His Ser Phe Pro 
785                 790                 795                 800 


Cys Pro Cys Pro Cys Asn Cys Ser Ser Thr Ile Gly Thr Thr Lys Glu 
                805                 810                 815     


Pro Leu Thr Arg Leu Gln His Asn Asn Ser Thr His Thr Arg Thr Ala 
            820                 825                 830         


Gly Leu Asn Thr Ser His Asn Arg Leu Leu Ser Thr Thr Ile Lys Ser 
        835                 840                 845             


Ala His Val Thr Asn Ser Ser Lys Arg Arg Asp Gln Asp Ser Ala Thr 
    850                 855                 860                 


His Ser His Thr Ser Pro Glu Thr Pro Ala Ser Gln Thr Glu Lys His 
865                 870                 875                 880 


His Thr Ala Thr His Pro His Thr Pro Pro Thr Lys Asp Gln Thr Gly 
                885                 890                 895     


Ala Thr Gly His Pro Ala Ala Asn Glu Thr Ser His His Pro Thr Pro 
            900                 905                 910         


Arg Thr Thr Thr Asn Pro Asp Ile His His Thr Thr Pro Pro Pro Gly 
        915                 920                 925             


Asn Pro Gln Pro Gly Asn Thr Ala Pro His Pro Glu Ala Ala Thr Lys 
    930                 935                 940                 


Ala Pro Thr Thr Thr Pro Gln Pro Arg Thr Asn His Thr Ala Asp Ala 
945                 950                 955                 960 


Ala Pro Gln Ala Asp Pro Pro Gln Lys Leu Asn Pro Thr Glu Gln Pro 
                965                 970                 975     


Ile Lys Thr Pro Thr Pro Thr Thr Thr Pro Thr Ala Pro Thr Thr Tyr 
            980                 985                 990         


Pro Asn Arg Thr Thr Glu Pro Asn  Pro Glu Asn Asn Asp  Thr Pro Ile 
        995                 1000                 1005             


His Pro  His Asn Asp Pro Thr  Arg Asp Thr Thr Thr  Ser Pro Ala 
    1010                 1015                 1020             


Asn His  Asn Thr Leu Asp Pro  His Gly Asp Pro Glu  Ala Glu Gly 
    1025                 1030                 1035             


Thr Thr  Thr Ser Glu Thr Thr  Ser Arg Ser Lys Pro  Ala Gly Asp 
    1040                 1045                 1050             


Thr Lys  Glu Thr Glu His Glu  Thr Leu Asp Ser Pro  Lys Asp Pro 
    1055                 1060                 1065             


His Val  Asp Thr Thr Thr Ser  Ala Thr Thr Thr Asp  Glu Gly Val 
    1070                 1075                 1080             


Asp Lys  Thr Ser Thr Asn Thr  Thr Gln His Ala His  Pro Thr Pro 
    1085                 1090                 1095             


Lys Gln  Arg Ser Gln Thr Thr  Asp Asn Thr Thr Arg  Pro Asp Ser 
    1100                 1105                 1110             


Pro Gln  Gln Asp Thr Ser Thr  Gln Thr Asp Thr Pro  Arg Asp Gln 
    1115                 1120                 1125             


Pro Asn  Ser Pro Gly Ala Asp  Pro Gly Gln Pro Pro  Pro Thr Asp 
    1130                 1135                 1140             


Pro Pro  Glu Glu Gln Arg Glu  Gly Gly Gln Pro Asp  Asn Lys Lys 
    1145                 1150                 1155             


Gln Glu  Glu Thr Ser Ser Asn  Asn Thr Lys Pro Glu  Asp Ala Lys 
    1160                 1165                 1170             


Ile Thr  Pro Asp Lys Ala Glu  Ser Arg Glu Thr Ser  Lys Pro Asn 
    1175                 1180                 1185             


Ser Ser  Ile Pro Thr Lys Glu  Glu Glu Arg Pro Asn  Ser Gln Pro 
    1190                 1195                 1200             


Leu Leu  Arg Gly Gly Glu Ser  Gln Thr Leu Arg Leu  Ser Asn Ile 
    1205                 1210                 1215             


Glu Asp  Leu His Ile Asp Asp  Thr Ser Pro Ser His  Thr Ser His 
    1220                 1225                 1230             


Ser Glu  Val Gln Pro Thr Pro  Lys Pro Pro Ser Glu  Glu Asn Pro 
    1235                 1240                 1245             


Ser Phe  Glu Leu Ile Asp Val  Ser His Asn Asn Pro  Lys Pro Asp 
    1250                 1255                 1260             


Glu Ser  Leu Thr Lys Pro Cys  Tyr Gln Ile Asp Arg  His Cys Thr 
    1265                 1270                 1275             


Asp Asn  Tyr Leu Ser Thr Ile  Gly Pro Leu Ile Asp  Cys Tyr Asn 
    1280                 1285                 1290             


Lys Thr  Glu Glu Val Leu Cys  Arg Leu Gln Thr Gln  Thr Ile Asp 
    1295                 1300                 1305             


Tyr Met  Glu Lys Asn Cys Pro  Gly Gly Tyr Leu Asn  Thr Ser Met 
    1310                 1315                 1320             


Ala Ser  Ile Leu Gly Val Ala  Tyr Ser Glu Tyr Gly  Asp Cys Arg 
    1325                 1330                 1335             


Arg Gly  Glu Ser Leu Lys Pro  Gly His Asn Tyr Ile  Cys Met Ile 
    1340                 1345                 1350             


Asn Gly  Thr Ser Tyr Leu Ala  Asp Arg Glu Phe Ile  Cys Arg Lys 
    1355                 1360                 1365             


Pro Ser  Tyr Lys Val Met Thr  Asn Leu Thr Thr Thr  Lys Leu Phe 
    1370                 1375                 1380             


His Ser  Ser Gln Ser Pro Phe  Asp Thr Val Gly His  Leu Ile Gly 
    1385                 1390                 1395             


Lys Tyr  Pro Phe Ser Tyr Gln  Glu Phe Ile Glu Trp  Ala Gly His 
    1400                 1405                 1410             


Tyr Tyr  Pro Arg Pro Thr Glu  Tyr Met Cys Gly Leu  Gly Glu Phe 
    1415                 1420                 1425             


Cys Gly  Tyr Thr Phe Val Phe  Phe Leu Ser Pro Asp  Phe Asn Ala 
    1430                 1435                 1440             


Tyr Phe  Glu Pro Thr Ile Tyr  Tyr Lys Ser Ile Glu  Lys Leu Asn 
    1445                 1450                 1455             


Arg Ser  Pro Ile Gln Ile Tyr  Asn Leu Cys Gly Arg  Val Phe Glu 
    1460                 1465                 1470             


Val Ala  Asp Gln Leu Thr Glu  Pro Tyr His Asn Val  Ile Val Thr 
    1475                 1480                 1485             


Pro Leu  Lys Asn Lys Val Leu  Ile Leu Arg Ser Leu  Ser Tyr Asn 
    1490                 1495                 1500             


Asp Phe  Ala Asp Leu Gly Gly  Asn Lys Thr Ser Cys  Asp Thr Ile 
    1505                 1510                 1515             


Leu Gln  Arg Arg Ala Tyr Phe  Ser Val Glu Thr Ser  Val Ala Lys 
    1520                 1525                 1530             


Glu Ala  Arg Lys Asn Lys Gly  Lys Leu Glu Ala Val  Thr Lys Ser 
    1535                 1540                 1545             


Pro Asn  Glu Lys Ile Thr Arg  Met Lys Arg Ala Thr  Asn Pro Ser 
    1550                 1555                 1560             


Tyr Gly  Ala Thr Pro Ser Tyr  Asp Thr Phe Gly Asp  Leu Ile Leu 
    1565                 1570                 1575             


Ser Ala  Leu Glu Ser Leu Trp  Tyr Lys Arg Arg 
    1580                 1585                 


<210>  372
<211>  546
<212>  PRT
<213>  Tailam jeilongvirus

<400>  372

Met Lys Leu Ser Val Val Tyr Thr Thr Leu Leu Val Ser Thr Phe Tyr 
1               5                   10                  15      


Ser Asp Leu Ala Arg Ser Gln Leu Ala Leu Ser Glu Leu Thr Lys Ile 
            20                  25                  30          


Gly Val Ile Pro Gly Arg Ser Tyr Asp Leu Lys Ile Ser Thr Gln Ala 
        35                  40                  45              


Ser Tyr Gln Tyr Met Val Val Lys Leu Ile Pro Asn Leu Thr Gly Leu 
    50                  55                  60                  


Asn Asn Cys Thr Asn Gly Thr Ile Glu Ala Tyr Lys Lys Met Leu Asn 
65                  70                  75                  80  


Arg Leu Leu Ser Pro Ile Asp Ala Ala Leu Arg Lys Met Lys Asp Ala 
                85                  90                  95      


Val Asn Asp Lys Pro Pro Glu Ser Val Gly Asn Val Lys Phe Trp Gly 
            100                 105                 110         


Ala Val Ile Gly Gly Val Ala Leu Gly Val Ala Thr Ser Ala Gln Ile 
        115                 120                 125             


Thr Ala Gly Val Ala Leu His Asn Ser Ile Gln Asn Ala Asn Ala Ile 
    130                 135                 140                 


Leu Ala Leu Lys Asp Ser Ile Arg Gln Ser Asn Lys Ala Ile Gln Glu 
145                 150                 155                 160 


Leu Gln Thr Ala Met Ser Thr Thr Val Val Val Leu Asn Ala Leu Gln 
                165                 170                 175     


Asp Gln Ile Asn Asn Gln Leu Val Pro Ala Ile Asn Ser Leu Gly Cys 
            180                 185                 190         


Gln Val Val Ala Asn Thr Leu Gly Leu Lys Leu Asn Gln Tyr Phe Ser 
        195                 200                 205             


Glu Ile Ser Leu Val Phe Gly Pro Asn Leu Arg Asp Pro Thr Ser Glu 
    210                 215                 220                 


Thr Leu Ser Ile Gln Ala Leu Ser Arg Ala Phe Asn Gly Asp Phe Asp 
225                 230                 235                 240 


Ser Met Leu Ser Lys Leu Lys Tyr Asp Asp Ser Asp Phe Leu Asp Leu 
                245                 250                 255     


Leu Glu Ser Asp Ser Ile Arg Gly Arg Ile Ile Asp Val Ser Leu Ser 
            260                 265                 270         


Asp Tyr Leu Ile Thr Ile Gln Ile Glu Tyr Pro Ala Leu Leu Ser Ile 
        275                 280                 285             


Lys Asp Ala Val Ile Gln Thr Phe Asn Leu Ile Ser Tyr Asn Thr Arg 
    290                 295                 300                 


Gly Thr Glu Trp Ile Ser Ile Phe Pro Lys Gln Leu Leu Val Arg Gly 
305                 310                 315                 320 


Thr Tyr Ile Ser Asn Ile Asp Ile Ser Gln Cys Val Ile Ala Ala Thr 
                325                 330                 335     


Ser Ile Ile Cys Lys Ser Asp Thr Ser Thr Pro Ile Ser Ser Ala Thr 
            340                 345                 350         


Trp Ser Cys Ala Thr Gly Asn Ile Thr Asn Cys Ala Arg Thr Arg Val 
        355                 360                 365             


Val Asn Ala His Val Pro Arg Phe Ala Leu Tyr Gly Gly Val Val Phe 
    370                 375                 380                 


Ala Asn Cys Ala Pro Val Val Cys Lys Cys Gln Asp Pro Leu Tyr Ser 
385                 390                 395                 400 


Ile Asn Gln Glu Pro Lys Val Thr Asn Val Met Val Asp Val Asp Ala 
                405                 410                 415     


Cys Lys Glu Met Tyr Leu Asp Gly Leu Tyr Ile Thr Leu Gly Lys Thr 
            420                 425                 430         


Gln Ile Ser Arg Ala Met Tyr Ala Glu Asp Val Ser Leu Gly Gly Pro 
        435                 440                 445             


Ile Ser Val Asp Pro Ile Asp Leu Gly Asn Glu Ile Asn Ser Ile Asn 
    450                 455                 460                 


Ser Ala Ile Asn Arg Ser Glu Glu His Leu Asn His Ala Asn Glu Leu 
465                 470                 475                 480 


Leu Asp Lys Val Asn Pro Arg Ile Val Asn Val Lys Thr Phe Gly Val 
                485                 490                 495     


Met Ile Gly Leu Leu Val Leu Val Val Leu Trp Cys Val Ile Thr Leu 
            500                 505                 510         


Val Trp Leu Ile Cys Leu Thr Lys Gln Leu Ala Arg Thr Ala Tyr Ala 
        515                 520                 525             


Gly Ser Met Gly Ser Arg Ala Ser Thr Val Asn Ser Leu Ser Gly Phe 
    530                 535                 540                 


Val Gly 
545     


<210>  373
<211>  1052
<212>  PRT
<213>  Tailam jeilongvirus

<400>  373

Met Ser Gln Leu Ala Ala His Asn Leu Ala Met Ser Asn Phe Tyr Gly 
1               5                   10                  15      


Ile His Gln Gly Gly Gln Ser Thr Ser Gln Lys Glu Glu Glu Gln Pro 
            20                  25                  30          


Val Gln Gly Val Ile Arg Tyr Ala Ser Met Ile Val Gly Leu Leu Ser 
        35                  40                  45              


Leu Phe Thr Ile Ile Ala Leu Asn Val Thr Asn Ile Ile Tyr Met Thr 
    50                  55                  60                  


Glu Ser Gly Gly Thr Met Gln Ser Ile Lys Asn Ala Gln Gly Ser Ile 
65                  70                  75                  80  


Asp Gly Ser Met Lys Asp Leu Ser Gly Thr Ile Met Glu Asp Ile Lys 
                85                  90                  95      


Pro Lys Thr Asp Leu Ile Asn Ser Met Val Ser Tyr Asn Ile Pro Ala 
            100                 105                 110         


Gln Leu Ser Met Ile His Gln Ile Ile Lys Asn Asp Val Leu Lys Gln 
        115                 120                 125             


Cys Thr Pro Ser Phe Met Phe Asn Asn Thr Ile Cys Pro Leu Ala Glu 
    130                 135                 140                 


Asn Pro Thr His Ser Arg Tyr Phe Glu Glu Val Asn Leu Asp Ser Ile 
145                 150                 155                 160 


Ser Glu Cys Ser Gly Asn Glu Met Ser Leu Glu Leu Gly Thr Glu Pro 
                165                 170                 175     


Glu Phe Ile Glu Tyr Pro Ser Phe Ala Pro Gly Ser Thr Lys Pro Gly 
            180                 185                 190         


Ser Cys Val Arg Leu Pro Ser Phe Ser Leu Ser Ser Thr Val Phe Ala 
        195                 200                 205             


Tyr Thr His Thr Ile Met Gly His Gly Cys Ser Glu Leu Asp Val Gly 
    210                 215                 220                 


Asp His Tyr Leu Ala Ile Gly Arg Ile Ala Asp Ala Gly His Glu Ile 
225                 230                 235                 240 


Pro Gln Phe Glu Thr Ile Ser Ser Trp Phe Ile Asn Asp Lys Ile Asn 
                245                 250                 255     


Arg Arg Ser Cys Thr Val Ala Ala Gly Val Met Glu Thr Trp Met Gly 
            260                 265                 270         


Cys Val Ile Met Thr Glu Thr Phe Tyr Asp Asp Leu Asp Ser Leu Asp 
        275                 280                 285             


Thr Gly Lys Ile Thr Ile Ser Tyr Leu Asp Val Phe Gly Arg Lys Lys 
    290                 295                 300                 


Glu Trp Ile Tyr Thr Arg Ser Glu Ile Leu Tyr Asp Tyr Thr Tyr Thr 
305                 310                 315                 320 


Ser Val Tyr Phe Ser Ile Gly Ser Gly Val Val Val Gly Asp Thr Val 
                325                 330                 335     


Tyr Phe Leu Leu Trp Gly Ser Leu Ser Ser Pro Ile Glu Glu Thr Ala 
            340                 345                 350         


Tyr Cys Tyr Ala Pro Gly Cys Ser Asn Tyr Asn Gln Arg Met Cys Asn 
        355                 360                 365             


Glu Ala Gln Arg Pro Ala Lys Phe Gly His Arg Gln Met Ala Asn Ala 
    370                 375                 380                 


Ile Leu Arg Phe Lys Thr Asn Ser Met Gly Lys Pro Ser Ile Ser Val 
385                 390                 395                 400 


Arg Thr Leu Ser Pro Thr Val Ile Pro Phe Gly Thr Glu Gly Arg Leu 
                405                 410                 415     


Ile Tyr Ser Asp Phe Thr Lys Ile Ile Tyr Leu Tyr Leu Arg Ser Thr 
            420                 425                 430         


Ser Trp Tyr Val Leu Pro Leu Thr Gly Leu Leu Ile Leu Gly Pro Pro 
        435                 440                 445             


Val Ser Ile Ser Trp Val Thr Gln Glu Ala Val Ser Arg Pro Gly Glu 
    450                 455                 460                 


Tyr Pro Cys Gly Ala Ser Asn Arg Cys Pro Lys Asp Cys Ile Thr Gly 
465                 470                 475                 480 


Val Tyr Thr Asp Leu Phe Pro Leu Gly Ala Arg Tyr Glu Tyr Ala Val 
                485                 490                 495     


Thr Val Tyr Leu Asn Ala Glu Thr Tyr Arg Val Asn Pro Thr Leu Ala 
            500                 505                 510         


Leu Ile Asp Arg Ser Lys Ile Ile Ala Arg Lys Lys Ile Thr Thr Glu 
        515                 520                 525             


Ser Gln Lys Ala Gly Tyr Thr Thr Thr Thr Cys Phe Val Phe Lys Leu 
    530                 535                 540                 


Arg Ile Trp Cys Met Ser Val Val Glu Leu Ala Pro Ala Thr Met Thr 
545                 550                 555                 560 


Ala Phe Glu Pro Val Pro Phe Leu Tyr Gln Leu Asp Leu Thr Cys Lys 
                565                 570                 575     


Arg Asn Asn Gly Thr Thr Ala Met Gln Phe Ser Gly Gln Asp Gly Met 
            580                 585                 590         


Tyr Lys Ser Gly Arg Tyr Lys Ser Pro Arg Asn Glu Cys Phe Phe Glu 
        595                 600                 605             


Lys Val Ser Asn Lys Tyr Tyr Phe Val Val Ser Thr Pro Glu Gly Ile 
    610                 615                 620                 


Gln Pro Tyr Glu Val Arg Asp Leu Thr Pro Glu Arg Val Ser His Val 
625                 630                 635                 640 


Ile Met Tyr Ile Ser Asp Val Cys Ala Pro Ala Leu Ser Ala Phe Lys 
                645                 650                 655     


Lys Leu Ile Pro Ala Met Arg Pro Ile Thr Thr Leu Thr Ile Gly Asn 
            660                 665                 670         


Trp Gln Phe Arg Pro Val Asp Ile Ser Gly Gly Leu Arg Val Asn Ile 
        675                 680                 685             


Tyr Arg Asn Leu Thr Arg Tyr Gly Asp Leu Ser Met Ser Ala Pro Glu 
    690                 695                 700                 


Asp Pro Gly Thr Asp Thr Phe Pro Gly Thr His Ala Pro Ser Lys Gly 
705                 710                 715                 720 


His Glu Glu Val Gly His Tyr Thr Leu Pro Asn Glu Lys Leu Ser Glu 
                725                 730                 735     


Val Thr Thr Ala Ala Val Lys Thr Lys Glu Ser Leu Asn Leu Ile Pro 
            740                 745                 750         


Asp Thr Lys Asp Thr Arg Gly Glu Glu Glu Asn Gly Ser Gly Leu Asn 
        755                 760                 765             


Glu Ile Ile Thr Gly His Thr Thr Pro Gly His Ile Lys Thr His Pro 
    770                 775                 780                 


Ala Glu Thr Lys Val Thr Lys His Thr Val Ile Ile Pro Gln Ile Glu 
785                 790                 795                 800 


Glu Asp Gly Ser Gly Ala Thr Thr Ser Thr Glu Leu Gln Asp Glu Thr 
                805                 810                 815     


Gly Tyr His Thr Glu Asp Tyr Asn Thr Thr Asn Thr Asn Gly Ser Leu 
            820                 825                 830         


Thr Ala Pro Asn Glu Arg Asn Asn Tyr Thr Ser Gly Asp His Thr Val 
        835                 840                 845             


Ser Gly Glu Asp Ile Thr His Thr Ile Thr Val Ser Asp Arg Thr Lys 
    850                 855                 860                 


Thr Thr Gln Thr Leu Pro Thr Asp Asn Thr Phe Asn Gln Thr Pro Thr 
865                 870                 875                 880 


Lys Ile Gln Glu Gly Ser Pro Lys Ser Glu Ser Thr Pro Lys Asp Tyr 
                885                 890                 895     


Thr Ala Ile Glu Ser Glu Asp Ser His Phe Thr Asp Pro Thr Leu Ile 
            900                 905                 910         


Arg Ser Thr Pro Glu Gly Thr Ile Val Gln Val Ile Gly Asp Gln Phe 
        915                 920                 925             


His Ser Ala Val Thr Gln Leu Gly Glu Ser Asn Ala Ile Gly Asn Ser 
    930                 935                 940                 


Glu Pro Ile Asp Gln Gly Asn Asn Leu Ile Pro Thr Thr Asp Arg Gly 
945                 950                 955                 960 


Thr Met Asp Asn Thr Ser Ser Gln Ser His Ser Ser Thr Thr Ser Thr 
                965                 970                 975     


Gln Gly Ser His Ser Ala Gly His Gly Ser Gln Ser Asn Met Asn Leu 
            980                 985                 990         


Thr Ala Leu Ala Asp Thr Asp Ser  Val Thr Asp Gln Ser  Thr Ser Thr 
        995                 1000                 1005             


Gln Glu  Ile Asp His Glu His  Glu Asn Val Ser Ser  Ile Leu Asn 
    1010                 1015                 1020             


Pro Leu  Ser Arg His Thr Arg  Val Met Arg Asp Thr  Val Gln Glu 
    1025                 1030                 1035             


Ala Leu  Thr Gly Ala Trp Gly  Phe Ile Arg Gly Met  Ile Pro 
    1040                 1045                 1050         


<210>  374
<211>  604
<212>  PRT
<213>  Canine morbillivirus

<400>  374

Met Leu Pro Tyr Gln Asp Lys Val Gly Ala Phe Tyr Lys Asp Asn Ala 
1               5                   10                  15      


Arg Ala Asn Ser Thr Lys Leu Ser Leu Val Thr Glu Gly His Gly Gly 
            20                  25                  30          


Arg Arg Pro Pro Tyr Leu Leu Phe Val Leu Leu Ile Leu Leu Val Gly 
        35                  40                  45              


Ile Leu Ala Leu Leu Ala Ile Thr Gly Val Arg Phe His Gln Val Ser 
    50                  55                  60                  


Thr Ser Asn Met Glu Phe Ser Arg Leu Leu Lys Glu Asp Met Glu Lys 
65                  70                  75                  80  


Ser Glu Ala Val His His Gln Val Ile Asp Val Leu Thr Pro Leu Phe 
                85                  90                  95      


Lys Ile Ile Gly Asp Glu Ile Gly Leu Arg Leu Pro Gln Lys Leu Asn 
            100                 105                 110         


Glu Ile Lys Gln Phe Ile Leu Gln Lys Thr Asn Phe Phe Asn Pro Asn 
        115                 120                 125             


Arg Glu Phe Asp Phe Arg Asp Leu His Trp Cys Ile Asn Pro Pro Ser 
    130                 135                 140                 


Thr Val Lys Val Asn Phe Thr Asn Tyr Cys Glu Ser Ile Gly Ile Arg 
145                 150                 155                 160 


Lys Ala Ile Ala Ser Ala Ala Asn Pro Ile Leu Leu Ser Ala Leu Ser 
                165                 170                 175     


Gly Gly Arg Gly Asp Ile Phe Pro Pro His Arg Cys Ser Gly Ala Thr 
            180                 185                 190         


Thr Ser Val Gly Lys Val Phe Pro Leu Ser Val Ser Leu Ser Met Ser 
        195                 200                 205             


Leu Ile Ser Arg Thr Ser Glu Val Ile Asn Met Leu Thr Ala Ile Ser 
    210                 215                 220                 


Asp Gly Val Tyr Gly Lys Thr Tyr Leu Leu Val Pro Asp Asp Ile Glu 
225                 230                 235                 240 


Arg Glu Phe Asp Thr Arg Glu Ile Arg Val Phe Glu Ile Gly Phe Ile 
                245                 250                 255     


Lys Arg Trp Leu Asn Asp Met Pro Leu Leu Gln Thr Thr Asn Tyr Met 
            260                 265                 270         


Val Leu Pro Lys Asn Ser Lys Ala Lys Val Cys Thr Ile Ala Val Gly 
        275                 280                 285             


Glu Leu Thr Leu Ala Ser Leu Cys Val Glu Glu Ser Thr Val Leu Leu 
    290                 295                 300                 


Tyr His Asp Ser Ser Gly Ser Gln Asp Gly Ile Leu Val Val Thr Leu 
305                 310                 315                 320 


Gly Ile Phe Trp Ala Thr Pro Met Asp His Ile Glu Glu Val Ile Pro 
                325                 330                 335     


Val Ala His Pro Ser Met Lys Lys Ile His Ile Thr Asn His Arg Gly 
            340                 345                 350         


Phe Ile Lys Asp Ser Ile Ala Thr Trp Met Val Pro Ala Leu Ala Ser 
        355                 360                 365             


Glu Lys Gln Glu Glu Gln Lys Gly Cys Leu Glu Ser Ala Cys Gln Arg 
    370                 375                 380                 


Lys Thr Tyr Pro Met Cys Asn Gln Ala Ser Trp Glu Pro Phe Gly Gly 
385                 390                 395                 400 


Arg Gln Leu Pro Ser Tyr Gly Arg Leu Thr Leu Pro Leu Asp Ala Ser 
                405                 410                 415     


Val Asp Leu Gln Leu Asn Ile Ser Phe Thr Tyr Gly Pro Val Ile Leu 
            420                 425                 430         


Asn Gly Asp Gly Met Asp Tyr Tyr Glu Ser Pro Leu Leu Asn Ser Gly 
        435                 440                 445             


Trp Leu Thr Ile Pro Pro Lys Asp Gly Thr Ile Ser Gly Leu Ile Asn 
    450                 455                 460                 


Lys Ala Gly Arg Gly Asp Gln Phe Thr Val Leu Pro His Val Leu Thr 
465                 470                 475                 480 


Phe Ala Pro Arg Glu Ser Ser Gly Asn Cys Tyr Leu Pro Ile Gln Thr 
                485                 490                 495     


Ser Gln Ile Arg Asp Arg Asp Val Leu Ile Glu Ser Asn Ile Val Val 
            500                 505                 510         


Leu Pro Thr Gln Ser Ile Arg Tyr Val Ile Ala Thr Tyr Asp Ile Ser 
        515                 520                 525             


Arg Ser Asp His Ala Ile Val Tyr Tyr Val Tyr Asp Pro Ile Arg Thr 
    530                 535                 540                 


Ile Ser Tyr Thr His Pro Phe Arg Leu Thr Thr Lys Gly Arg Pro Asp 
545                 550                 555                 560 


Phe Leu Arg Ile Glu Cys Phe Val Trp Asp Asp Asn Leu Trp Cys His 
                565                 570                 575     


Gln Phe Tyr Arg Phe Glu Ala Asp Ile Ala Asn Ser Thr Thr Ser Val 
            580                 585                 590         


Glu Asn Leu Val Arg Ile Arg Phe Ser Cys Asn Arg 
        595                 600                 


<210>  375
<211>  662
<212>  PRT
<213>  Canine morbillivirus

<400>  375

Met His Arg Gly Ile Pro Lys Ser Ser Lys Thr Gln Thr His Thr Gln 
1               5                   10                  15      


Gln Asp Arg Pro Pro Gln Pro Ser Thr Glu Leu Glu Glu Thr Arg Thr 
            20                  25                  30          


Ser Arg Ala Arg His Ser Thr Thr Ser Ala Gln Arg Ser Thr His Tyr 
        35                  40                  45              


Asp Pro Arg Thr Ser Asp Arg Pro Val Ser Tyr Thr Met Asn Arg Thr 
    50                  55                  60                  


Arg Ser Arg Lys Gln Thr Ser His Arg Leu Lys Asn Ile Pro Val His 
65                  70                  75                  80  


Gly Asn His Glu Ala Thr Ile Gln His Ile Pro Glu Ser Val Ser Lys 
                85                  90                  95      


Gly Ala Arg Ser Gln Ile Glu Arg Arg Gln Pro Asn Ala Ile Asn Ser 
            100                 105                 110         


Gly Ser His Cys Thr Trp Leu Val Leu Trp Cys Leu Gly Met Ala Ser 
        115                 120                 125             


Leu Phe Leu Cys Ser Lys Ala Gln Ile His Trp Asp Asn Leu Ser Thr 
    130                 135                 140                 


Ile Gly Ile Ile Gly Thr Asp Asn Val His Tyr Lys Ile Met Thr Arg 
145                 150                 155                 160 


Pro Ser His Gln Tyr Leu Val Ile Lys Leu Ile Pro Asn Ala Ser Leu 
                165                 170                 175     


Ile Glu Asn Cys Thr Lys Ala Glu Leu Gly Glu Tyr Glu Lys Leu Leu 
            180                 185                 190         


Asn Ser Val Leu Glu Pro Ile Asn Gln Ala Leu Thr Leu Met Thr Lys 
        195                 200                 205             


Asn Val Lys Pro Leu Gln Ser Leu Gly Ser Gly Arg Arg Gln Arg Arg 
    210                 215                 220                 


Phe Ala Gly Val Val Leu Ala Gly Val Ala Leu Gly Val Ala Thr Ala 
225                 230                 235                 240 


Ala Gln Ile Thr Ala Gly Ile Ala Leu His Gln Ser Asn Leu Asn Ala 
                245                 250                 255     


Gln Ala Ile Gln Ser Leu Arg Thr Ser Leu Glu Gln Ser Asn Lys Ala 
            260                 265                 270         


Ile Glu Glu Ile Arg Glu Ala Thr Gln Glu Thr Val Ile Ala Val Gln 
        275                 280                 285             


Gly Val Gln Asp Tyr Val Asn Asn Glu Leu Val Pro Ala Met Gln His 
    290                 295                 300                 


Met Ser Cys Glu Leu Val Gly Gln Arg Leu Gly Leu Arg Leu Leu Arg 
305                 310                 315                 320 


Tyr Tyr Thr Glu Leu Leu Ser Ile Phe Gly Pro Ser Leu Arg Asp Pro 
                325                 330                 335     


Ile Ser Ala Glu Ile Ser Ile Gln Ala Leu Ile Tyr Ala Leu Gly Gly 
            340                 345                 350         


Glu Ile His Lys Ile Leu Glu Lys Leu Gly Tyr Ser Gly Ser Asp Met 
        355                 360                 365             


Ile Ala Ile Leu Glu Ser Arg Gly Ile Lys Thr Lys Ile Thr His Val 
    370                 375                 380                 


Asp Leu Pro Gly Lys Phe Ile Ile Leu Ser Ile Ser Tyr Pro Thr Leu 
385                 390                 395                 400 


Ser Glu Val Lys Gly Val Ile Val His Arg Leu Glu Ala Val Ser Tyr 
                405                 410                 415     


Asn Ile Gly Ser Gln Glu Trp Tyr Thr Thr Val Pro Arg Tyr Ile Ala 
            420                 425                 430         


Thr Asn Gly Tyr Leu Ile Ser Asn Phe Asp Glu Ser Ser Cys Val Phe 
        435                 440                 445             


Val Ser Glu Ser Ala Ile Cys Ser Gln Asn Ser Leu Tyr Pro Met Ser 
    450                 455                 460                 


Pro Leu Leu Gln Gln Cys Ile Arg Gly Asp Thr Ser Ser Cys Ala Arg 
465                 470                 475                 480 


Thr Leu Val Ser Gly Thr Met Gly Asn Lys Phe Ile Leu Ser Lys Gly 
                485                 490                 495     


Asn Ile Val Ala Asn Cys Ala Ser Ile Leu Cys Lys Cys Tyr Ser Thr 
            500                 505                 510         


Ser Thr Ile Ile Asn Gln Ser Pro Asp Lys Leu Leu Thr Phe Ile Ala 
        515                 520                 525             


Ser Asp Thr Cys Pro Leu Val Glu Ile Asp Gly Ala Thr Ile Gln Val 
    530                 535                 540                 


Gly Gly Arg Gln Tyr Pro Asp Met Val Tyr Glu Gly Lys Val Ala Leu 
545                 550                 555                 560 


Gly Pro Ala Ile Ser Leu Asp Arg Leu Asp Val Gly Thr Asn Leu Gly 
                565                 570                 575     


Asn Ala Leu Lys Lys Leu Asp Asp Ala Lys Val Leu Ile Asp Ser Ser 
            580                 585                 590         


Asn Gln Ile Leu Glu Thr Val Arg Arg Ser Ser Phe Asn Phe Gly Ser 
        595                 600                 605             


Leu Leu Ser Val Pro Ile Leu Ser Cys Thr Ala Leu Ala Leu Leu Leu 
    610                 615                 620                 


Leu Ile Tyr Cys Cys Lys Arg Arg Tyr Gln Gln Thr Leu Lys Gln His 
625                 630                 635                 640 


Thr Lys Val Asp Pro Ala Phe Lys Pro Asp Leu Thr Gly Thr Ser Lys 
                645                 650                 655     


Ser Tyr Val Arg Ser Leu 
            660         


<210>  376
<211>  604
<212>  PRT
<213>  Cetacean morbillivirus

<400>  376

Met Ser Ser Pro Arg Asp Lys Val Asp Ala Phe Tyr Lys Asp Ile Pro 
1               5                   10                  15      


Arg Pro Arg Asn Asn Arg Val Leu Leu Asp Asn Glu Arg Val Ile Ile 
            20                  25                  30          


Glu Arg Pro Leu Ile Leu Val Gly Val Leu Ala Val Met Phe Leu Ser 
        35                  40                  45              


Leu Val Gly Leu Leu Ala Ile Ala Gly Val Arg Leu Gln Lys Ala Thr 
    50                  55                  60                  


Thr Asn Ser Ile Glu Val Asn Arg Lys Leu Ser Thr Asn Leu Glu Thr 
65                  70                  75                  80  


Thr Val Ser Ile Glu His His Val Lys Asp Val Leu Thr Pro Leu Phe 
                85                  90                  95      


Lys Ile Ile Gly Asp Glu Val Gly Leu Arg Met Pro Gln Lys Leu Thr 
            100                 105                 110         


Glu Ile Met Gln Phe Ile Ser Asn Lys Ile Lys Phe Leu Asn Pro Asp 
        115                 120                 125             


Arg Glu Tyr Asp Phe Asn Asp Leu His Trp Cys Val Asn Pro Pro Asp 
    130                 135                 140                 


Gln Val Lys Ile Asp Tyr Ala Gln Tyr Cys Asn His Ile Ala Ala Glu 
145                 150                 155                 160 


Glu Leu Ile Val Thr Lys Phe Lys Glu Leu Met Asn His Ser Leu Asp 
                165                 170                 175     


Met Ser Lys Gly Arg Ile Phe Pro Pro Lys Asn Cys Ser Gly Ser Val 
            180                 185                 190         


Ile Thr Arg Gly Gln Thr Ile Lys Pro Gly Leu Thr Leu Val Asn Ile 
        195                 200                 205             


Tyr Thr Thr Arg Asn Phe Glu Val Ser Phe Met Val Thr Val Ile Ser 
    210                 215                 220                 


Gly Gly Met Tyr Gly Lys Thr Tyr Phe Leu Lys Pro Pro Glu Pro Asp 
225                 230                 235                 240 


Asp Pro Phe Glu Phe Gln Ala Phe Arg Ile Phe Glu Val Gly Leu Val 
                245                 250                 255     


Arg Asp Val Gly Ser Arg Glu Pro Val Leu Gln Met Thr Asn Phe Met 
            260                 265                 270         


Val Ile Asp Glu Asp Glu Gly Leu Asn Phe Cys Leu Leu Ser Val Gly 
        275                 280                 285             


Glu Leu Arg Leu Ala Ala Val Cys Val Arg Gly Arg Pro Val Val Thr 
    290                 295                 300                 


Lys Asp Ile Gly Gly Tyr Lys Asp Glu Pro Phe Lys Val Val Thr Leu 
305                 310                 315                 320 


Gly Ile Ile Gly Gly Gly Leu Ser Asn Gln Lys Thr Glu Ile Tyr Pro 
                325                 330                 335     


Thr Ile Asp Ser Ser Ile Glu Lys Leu Tyr Ile Thr Ser His Arg Gly 
            340                 345                 350         


Ile Ile Arg Asn Ser Lys Ala Arg Trp Ser Val Pro Ala Ile Arg Ser 
        355                 360                 365             


Asp Asp Lys Asp Lys Met Glu Lys Cys Thr Gln Ala Leu Cys Lys Ser 
    370                 375                 380                 


Arg Pro Pro Pro Ser Cys Asn Ser Ser Asp Trp Glu Pro Leu Thr Ser 
385                 390                 395                 400 


Asn Arg Ile Pro Ala Tyr Ala Tyr Ile Ala Leu Glu Ile Lys Glu Asp 
                405                 410                 415     


Ser Gly Leu Glu Leu Asp Ile Thr Ser Asn Tyr Gly Pro Leu Ile Ile 
            420                 425                 430         


His Gly Ala Gly Met Asp Ile Tyr Glu Gly Pro Ser Ser Asn Gln Asp 
        435                 440                 445             


Trp Leu Ala Ile Pro Pro Leu Ser Gln Ser Val Leu Gly Val Ile Asn 
    450                 455                 460                 


Lys Val Asp Phe Thr Ala Gly Phe Asp Ile Lys Pro His Thr Leu Thr 
465                 470                 475                 480 


Thr Ala Val Asp Tyr Glu Ser Gly Lys Cys Tyr Val Pro Val Glu Leu 
                485                 490                 495     


Ser Gly Ala Lys Asp Gln Asp Leu Lys Leu Glu Ser Asn Leu Val Val 
            500                 505                 510         


Leu Pro Thr Lys Asp Phe Gly Tyr Val Thr Ala Thr Tyr Asp Thr Ser 
        515                 520                 525             


Arg Ser Glu His Ala Ile Val Tyr Tyr Val Tyr Asp Thr Ala Arg Ser 
    530                 535                 540                 


Ser Ser Tyr Phe Phe Pro Phe Arg Ile Lys Ala Arg Gly Glu Pro Ile 
545                 550                 555                 560 


Tyr Leu Arg Ile Glu Cys Phe Pro Trp Ser Arg Gln Leu Trp Cys His 
                565                 570                 575     


His Tyr Cys Met Ile Asn Ser Thr Val Ser Asn Glu Ile Val Val Val 
            580                 585                 590         


Asp Asn Leu Val Ser Ile Asn Met Ser Cys Ser Arg 
        595                 600                 


<210>  377
<211>  552
<212>  PRT
<213>  Cetacean morbillivirus

<400>  377

Met Ala Ser Asn Asp Asn Ser Val Ile Tyr His Ser Phe Leu Thr Val 
1               5                   10                  15      


Ile Leu Leu Val Val Val Thr Glu Gly Gln Ile His Trp Gly Asn Leu 
            20                  25                  30          


Ser Lys Ile Gly Ile Val Gly Thr Gly Ser Ala Ser Tyr Lys Val Met 
        35                  40                  45              


Thr Arg Pro Ser His Gln Tyr Leu Val Ile Lys Leu Met Pro Asn Val 
    50                  55                  60                  


Thr Met Ile Asp Asn Cys Thr Arg Thr Glu Val Ala Glu Tyr Arg Lys 
65                  70                  75                  80  


Leu Leu Lys Thr Val Leu Glu Pro Val Arg Asn Ala Leu Thr Val Ile 
                85                  90                  95      


Thr Lys Asn Ile Lys Pro Ile Gln Ser Leu Thr Thr Ser Arg Arg Ser 
            100                 105                 110         


Lys Arg Phe Ala Gly Val Val Leu Ala Gly Val Ala Leu Gly Val Ala 
        115                 120                 125             


Thr Ala Ala Gln Ile Thr Ala Gly Ile Ala Leu His Gln Ser Ile Met 
    130                 135                 140                 


Asn Ser Gln Ser Ile Asp Asn Leu Arg Thr Ser Leu Glu Lys Ser Asn 
145                 150                 155                 160 


Gln Ala Ile Glu Glu Ile Arg Gln Ala Ser Gln Glu Thr Val Leu Ala 
                165                 170                 175     


Val Gln Gly Val Gln Asp Phe Ile Asn Asn Glu Leu Ile Pro Ser Met 
            180                 185                 190         


His Gln Leu Ser Cys Glu Met Leu Gly Gln Lys Leu Gly Leu Lys Leu 
        195                 200                 205             


Leu Arg Tyr Tyr Thr Glu Ile Leu Ser Ile Phe Gly Pro Ser Leu Arg 
    210                 215                 220                 


Asp Pro Val Ser Ala Glu Ile Ser Ile Gln Ala Leu Thr Tyr Ala Leu 
225                 230                 235                 240 


Gly Gly Asp Ile Asn Lys Val Leu Glu Lys Leu Gly Tyr Ser Gly Ala 
                245                 250                 255     


Asp Leu Leu Ala Ile Leu Glu Ser Arg Gly Ile Lys Ala Lys Ile Thr 
            260                 265                 270         


His Val Asp Leu Glu Gly Tyr Phe Ile Val Leu Ser Ile Ala Tyr Pro 
        275                 280                 285             


Thr Leu Ser Glu Val Lys Gly Val Ile Val His Arg Leu Glu Ala Val 
    290                 295                 300                 


Ser Tyr Asn Leu Gly Ser Gln Glu Trp Tyr Thr Thr Leu Pro Arg Tyr 
305                 310                 315                 320 


Val Ala Thr Asn Gly Tyr Leu Ile Ser Asn Phe Asp Glu Ser Ser Cys 
                325                 330                 335     


Ala Phe Met Ser Glu Val Thr Ile Cys Ser Gln Asn Ala Leu Tyr Pro 
            340                 345                 350         


Met Ser Pro Leu Leu Gln Gln Cys Leu Arg Gly Ser Thr Ala Ser Cys 
        355                 360                 365             


Ala Arg Ser Leu Val Ser Gly Thr Ile Gly Asn Arg Phe Ile Leu Ser 
    370                 375                 380                 


Lys Gly Asn Leu Ile Ala Asn Cys Ala Ser Val Leu Cys Lys Cys Tyr 
385                 390                 395                 400 


Ser Thr Gly Thr Ile Ile Ser Gln Asp Pro Asp Lys Leu Leu Thr Phe 
                405                 410                 415     


Val Ala Ala Asp Lys Cys Pro Leu Val Glu Val Asp Gly Ile Thr Ile 
            420                 425                 430         


Gln Val Gly Ser Arg Glu Tyr Pro Asp Ser Val Tyr Val Ser Arg Ile 
        435                 440                 445             


Asp Leu Gly Pro Pro Ile Ser Leu Glu Lys Leu Asp Val Gly Thr Asn 
    450                 455                 460                 


Leu Gly Asn Ala Leu Thr Lys Leu Asn Asn Ala Lys Glu Leu Leu Asp 
465                 470                 475                 480 


Ser Ser Asn Gln Ile Leu Glu Asn Val Arg Arg Gly Ser Phe Gly Gly 
                485                 490                 495     


Ala Met Tyr Ile Gly Ile Leu Val Cys Ala Gly Ala Leu Val Ile Leu 
            500                 505                 510         


Cys Val Leu Val Tyr Cys Cys Lys Arg Tyr Cys Cys Ser Arg Val Gln 
        515                 520                 525             


Ile Val Pro Lys Ser Thr Pro Gly Leu Lys Pro Asp Leu Thr Gly Thr 
    530                 535                 540                 


Thr Lys Ser Tyr Val Arg Ser Leu 
545                 550         


<210>  378
<211>  514
<212>  PRT
<213>  Feline morbillivirus

<400>  378

Met Asn Arg Ile Arg Val Ile Ile Ile Ser Ser Leu Leu Leu Ser Asp 
1               5                   10                  15      


Ile Thr Ile Ala Gln Ile Gly Trp Asp Asn Leu Thr Ser Ile Gly Val 
            20                  25                  30          


Ile Ser Thr Lys Gln Tyr Asn Tyr Lys Ile Thr Thr Leu Asn Thr Asn 
        35                  40                  45              


Gln Leu Met Val Ile Lys Met Val Pro Asn Ile Ser Ser Ile Ile Asn 
    50                  55                  60                  


Cys Thr Lys Leu Glu Leu Ile Lys Tyr Arg Glu Leu Ile Ser Gly Ile 
65                  70                  75                  80  


Ile Arg Pro Ile Asn Glu Ser Leu Glu Leu Met Asn Ser Tyr Ile Asn 
                85                  90                  95      


Met Arg Val Gly Ser Glu Arg Phe Ile Gly Ala Val Ile Ala Gly Val 
            100                 105                 110         


Ala Leu Gly Val Ala Thr Ala Ala Gln Ile Thr Ser Gly Ile Ala Leu 
        115                 120                 125             


His Asn Ser Ile Met Asn Lys Lys Gln Ile Gln Glu Leu Arg Lys Ala 
    130                 135                 140                 


Leu Ser Thr Thr Asn Lys Ala Ile Asp Glu Ile Arg Ile Ala Gly Glu 
145                 150                 155                 160 


Arg Thr Leu Met Ala Val Gln Arg Val Gln Asp Tyr Ile Asn Asn Ile 
                165                 170                 175     


Ile Val Pro Met Gln Asp Lys Leu Gln Cys Asp Ile Leu Ser Ser Gln 
            180                 185                 190         


Leu Ala Val Ala Leu Leu Arg Tyr Tyr Thr Asn Ile Val Thr Val Phe 
        195                 200                 205             


Glu Pro Ser Ile Arg His Pro Ile Thr Ser Thr Ile Ser Leu Gln Pro 
    210                 215                 220                 


Leu Ser Gln Pro Phe Asn Gly Asn Leu Gln Ala Leu Leu Asp Gly Ile 
225                 230                 235                 240 


Ala Tyr Thr Gly Arg Asp Leu Arg Asp Leu Leu Glu Ser Lys Ser Ile 
                245                 250                 255     


Thr Gly Gln Ile Ile His Ala Asp Met Thr Asp Leu Phe Leu Val Leu 
            260                 265                 270         


Arg Ile Asn Tyr Pro Ser Ile Thr Glu Met Gln Gly Val Thr Ile Tyr 
        275                 280                 285             


Glu Leu Asn Ser Ile Thr Tyr His Ile Gly Pro Glu Glu Trp Tyr Thr 
    290                 295                 300                 


Ile Met Pro Asp Phe Ile Ala Val Gln Gly Phe Leu Ile Ser Asn Phe 
305                 310                 315                 320 


Asp Glu Arg Lys Cys Ser Ile Thr Lys Ser Ser Val Leu Cys Gln Gln 
                325                 330                 335     


Asn Ser Ile Tyr Pro Met Ser Thr Glu Met Gln Arg Cys Ile Lys Gly 
            340                 345                 350         


Glu Ile Arg Phe Cys Pro Arg Ser Lys Ala Ile Gly Thr Leu Val Asn 
        355                 360                 365             


Arg Phe Ile Leu Thr Lys Gly Asn Leu Met Ala Asn Cys Leu Gly Ile 
    370                 375                 380                 


Ile Cys Arg Cys Tyr Thr Ser Gly Gln Val Ile Thr Gln Asp Pro Ser 
385                 390                 395                 400 


Lys Leu Ile Thr Ile Ile Ser Gln Glu Glu Cys Lys Glu Val Gly Val 
                405                 410                 415     


Asp Gly Ile Arg Ile Met Val Gly Pro Arg Lys Leu Pro Asp Ile Thr 
            420                 425                 430         


Phe Asn Ala Arg Leu Glu Ile Gly Val Pro Ile Ser Leu Thr Lys Leu 
        435                 440                 445             


Asp Val Gly Asn Asp Leu Ala Ile Ala Ser Ala Lys Leu Asn Asn Ser 
    450                 455                 460                 


Lys Pro Trp Leu Glu Gln Ser Glu Arg Ile Pro Asp Ser Met Ser Lys 
465                 470                 475                 480 


Ser Asn Ser Ile Lys Ser Arg Ile Thr Arg Leu Thr Leu Ala Ile Met 
                485                 490                 495     


Ile Ile Phe Ile Ile Ile Ile Thr Ile Ile Trp Ile Ile Tyr Lys Asn 
            500                 505                 510         


Cys Arg 
        


<210>  379
<211>  595
<212>  PRT
<213>  Feline morbillivirus

<400>  379

Met Glu Ser Asn Asn Ile Lys Tyr Tyr Lys Asp Ser Asn Arg Tyr Leu 
1               5                   10                  15      


Gly Lys Ile Leu Asp Glu His Lys Ile Val Asn Ser Gln Leu Tyr Ser 
            20                  25                  30          


Leu Ser Ile Lys Val Ile Thr Ile Ile Ala Ile Ile Val Ser Leu Ile 
        35                  40                  45              


Ala Thr Ile Met Thr Ile Ile Asn Ala Thr Ser Gly Arg Thr Thr Leu 
    50                  55                  60                  


Asn Ser Asn Thr Asp Ile Leu Leu Asn Gln Arg Gly Glu Ile His Ser 
65                  70                  75                  80  


Ile His Glu Met Ile Phe Asp Arg Val Tyr Pro Leu Ile Thr Ala Met 
                85                  90                  95      


Ser Thr Glu Leu Gly Leu His Ile Pro Thr Leu Leu Asp Glu Leu Thr 
            100                 105                 110         


Lys Ala Ile Asp Gln Lys Ile Lys Ile Met Asn Pro Pro Val Asn Thr 
        115                 120                 125             


Val Thr Ser Asp Leu Ser Trp Cys Ile Lys Pro Pro Asn Gly Ile Ile 
    130                 135                 140                 


Ile Asp Pro Lys Gly Tyr Cys Glu Ser Met Glu Leu Ser Lys Thr Tyr 
145                 150                 155                 160 


Lys Leu Leu Leu Asp Gln Leu Asp Val Ser Arg Lys Lys Ser Leu Thr 
                165                 170                 175     


Ile Asn Arg Lys Asn Ile Asn Gln Cys Gln Leu Val Asp Asp Ser Lys 
            180                 185                 190         


Ile Ile Phe Ala Thr Val Asn Ile Gln Ser Thr Pro Arg Phe Leu Asn 
        195                 200                 205             


Phe Gly His Thr Val Ser Asn Gln Arg Ile Thr Phe Gly Gln Gly Thr 
    210                 215                 220                 


Tyr Ser Ser Thr Tyr Ile Leu Thr Ile Gln Glu Asp Gly Ile Thr Asp 
225                 230                 235                 240 


Val Gln Tyr Arg Val Phe Glu Ile Gly Tyr Ile Ser Asp Gln Phe Gly 
                245                 250                 255     


Val Phe Pro Ser Leu Ile Val Ser Arg Val Leu Pro Ile Arg Met Val 
            260                 265                 270         


Leu Gly Met Glu Ser Cys Thr Leu Thr Ser Asp Arg Gln Gly Gly Tyr 
        275                 280                 285             


Phe Leu Cys Met Asn Thr Leu Thr Arg Ser Ile Tyr Asp Tyr Val Asn 
    290                 295                 300                 


Ile Arg Asp Leu Lys Ser Leu Tyr Ile Thr Leu Pro His Tyr Gly Lys 
305                 310                 315                 320 


Val Asn Tyr Thr Tyr Phe Asn Phe Gly Lys Ile Arg Ser Pro His Glu 
                325                 330                 335     


Ile Asp Lys Leu Trp Leu Thr Ser Asp Arg Gly Gln Ile Ile Ser Gly 
            340                 345                 350         


Tyr Phe Ala Ala Phe Val Thr Ile Thr Ile Arg Asn Tyr Asn Asn Tyr 
        355                 360                 365             


Pro Tyr Lys Cys Leu Asn Asn Pro Cys Phe Asp Asn Ser Glu Asn Tyr 
    370                 375                 380                 


Cys Arg Gly Trp Tyr Lys Asn Ile Thr Gly Thr Asp Asp Val Pro Ile 
385                 390                 395                 400 


Leu Ala Tyr Leu Leu Val Glu Met Tyr Asp Glu Glu Gly Pro Leu Ile 
                405                 410                 415     


Thr Leu Val Ala Ile Pro Pro Tyr Asn Tyr Thr Ala Pro Ser His Asn 
            420                 425                 430         


Ser Leu Tyr Tyr Asp Asp Lys Ile Asn Lys Leu Ile Met Thr Thr Ser 
        435                 440                 445             


His Ile Gly Tyr Ile Gln Ile Asn Glu Val His Glu Val Ile Val Gly 
    450                 455                 460                 


Asp Asn Leu Lys Ala Ile Leu Leu Asn Arg Leu Ser Asp Glu His Pro 
465                 470                 475                 480 


Asn Leu Thr Ala Cys Arg Leu Asn Gln Gly Ile Lys Glu Gln Tyr Lys 
                485                 490                 495     


Ser Asp Gly Met Ile Ile Ser Asn Ser Ala Leu Ile Asp Ile Gln Glu 
            500                 505                 510         


Arg Met Tyr Ile Thr Val Lys Ala Ile Pro Pro Val Gly Asn Tyr Asn 
        515                 520                 525             


Phe Thr Ile Glu Leu His Ser Arg Ser Asn Thr Ser Tyr Ile Leu Leu 
    530                 535                 540                 


Pro Lys Gln Phe Asn Ala Lys Tyr Asp Lys Leu His Leu Glu Cys Phe 
545                 550                 555                 560 


Asn Trp Asp Lys Ser Trp Trp Cys Ala Leu Ile Pro Gln Phe Ser Leu 
                565                 570                 575     


Ser Trp Asn Glu Ser Leu Ser Val Asp Thr Ala Ile Phe Asn Leu Ile 
            580                 585                 590         


Asn Cys Lys 
        595 


<210>  380
<211>  550
<212>  PRT
<213>  Measles morbillivirus

<400>  380

Met Gly Leu Lys Val Asn Val Ser Ala Ile Phe Met Ala Val Leu Leu 
1               5                   10                  15      


Thr Leu Gln Thr Pro Thr Gly Gln Ile His Trp Gly Asn Leu Ser Lys 
            20                  25                  30          


Ile Gly Val Val Gly Ile Gly Ser Ala Ser Tyr Lys Val Met Thr Arg 
        35                  40                  45              


Ser Ser His Gln Ser Leu Val Ile Lys Leu Met Pro Asn Ile Thr Leu 
    50                  55                  60                  


Leu Asn Asn Cys Thr Arg Val Glu Ile Ala Glu Tyr Arg Arg Leu Leu 
65                  70                  75                  80  


Arg Thr Val Leu Glu Pro Ile Arg Asp Ala Leu Asn Ala Met Thr Gln 
                85                  90                  95      


Asn Ile Arg Pro Val Gln Ser Val Ala Ser Ser Arg Arg His Lys Arg 
            100                 105                 110         


Phe Ala Gly Val Val Leu Ala Gly Ala Ala Leu Gly Val Ala Thr Ala 
        115                 120                 125             


Ala Gln Ile Thr Ala Gly Ile Ala Leu His Gln Ser Met Leu Asn Ser 
    130                 135                 140                 


Gln Ala Ile Asp Asn Leu Arg Ala Ser Leu Glu Thr Thr Asn Gln Ala 
145                 150                 155                 160 


Ile Glu Ala Ile Arg Gln Ala Gly Gln Glu Met Ile Leu Ala Val Gln 
                165                 170                 175     


Gly Val Gln Asp Tyr Ile Asn Asn Glu Leu Ile Pro Ser Met Asn Gln 
            180                 185                 190         


Leu Ser Cys Asp Leu Ile Gly Gln Lys Leu Gly Leu Lys Leu Leu Arg 
        195                 200                 205             


Tyr Tyr Thr Glu Ile Leu Ser Leu Phe Gly Pro Ser Leu Arg Asp Pro 
    210                 215                 220                 


Ile Ser Ala Glu Ile Ser Ile Gln Ala Leu Ser Tyr Ala Leu Gly Gly 
225                 230                 235                 240 


Asp Ile Asn Lys Val Leu Glu Lys Leu Gly Tyr Ser Gly Gly Asp Leu 
                245                 250                 255     


Leu Gly Ile Leu Glu Ser Arg Gly Ile Lys Ala Arg Ile Thr His Val 
            260                 265                 270         


Asp Thr Glu Ser Tyr Phe Ile Val Leu Ser Ile Ala Tyr Pro Thr Leu 
        275                 280                 285             


Ser Glu Ile Lys Gly Val Ile Val His Arg Leu Glu Gly Val Ser Tyr 
    290                 295                 300                 


Asn Ile Gly Ser Gln Glu Trp Tyr Thr Thr Val Pro Lys Tyr Val Ala 
305                 310                 315                 320 


Thr Gln Gly Tyr Leu Ile Ser Asn Phe Asp Glu Ser Ser Cys Thr Phe 
                325                 330                 335     


Met Pro Glu Gly Thr Val Cys Ser Gln Asn Ala Leu Tyr Pro Met Ser 
            340                 345                 350         


Pro Leu Leu Gln Glu Cys Leu Arg Gly Ser Thr Lys Ser Cys Ala Arg 
        355                 360                 365             


Thr Leu Val Ser Gly Ser Phe Gly Asn Arg Phe Ile Leu Ser Gln Gly 
    370                 375                 380                 


Asn Leu Ile Ala Asn Cys Ala Ser Ile Leu Cys Lys Cys Tyr Thr Thr 
385                 390                 395                 400 


Gly Thr Ile Ile Asn Gln Asp Pro Asp Lys Ile Leu Thr Tyr Ile Ala 
                405                 410                 415     


Ala Asp His Cys Pro Val Val Glu Val Asn Gly Val Thr Ile Gln Val 
            420                 425                 430         


Gly Ser Arg Arg Tyr Pro Asp Ala Val Tyr Leu His Arg Ile Asp Leu 
        435                 440                 445             


Gly Pro Pro Ile Ser Leu Glu Arg Leu Asp Val Gly Thr Asn Leu Gly 
    450                 455                 460                 


Asn Ala Ile Ala Lys Leu Glu Asp Ala Lys Glu Leu Leu Glu Ser Ser 
465                 470                 475                 480 


Asp Gln Ile Leu Arg Ser Met Lys Gly Leu Ser Ser Thr Ser Ile Val 
                485                 490                 495     


Tyr Ile Leu Ile Ala Val Cys Leu Gly Gly Leu Ile Gly Ile Pro Ala 
            500                 505                 510         


Leu Ile Cys Cys Cys Arg Gly Arg Cys Asn Lys Lys Gly Glu Gln Val 
        515                 520                 525             


Gly Met Ser Arg Pro Gly Leu Lys Pro Asp Leu Thr Gly Thr Ser Lys 
    530                 535                 540                 


Ser Tyr Val Arg Ser Leu 
545                 550 


<210>  381
<211>  617
<212>  PRT
<213>  Measles morbillivirus

<400>  381

Met Ser Pro Gln Arg Asp Arg Ile Asn Ala Phe Tyr Lys Asp Asn Pro 
1               5                   10                  15      


His Pro Lys Gly Ser Arg Ile Val Ile Asn Arg Glu His Leu Met Ile 
            20                  25                  30          


Asp Arg Pro Tyr Val Leu Leu Ala Val Leu Phe Val Met Phe Leu Ser 
        35                  40                  45              


Leu Ile Gly Leu Leu Ala Ile Ala Gly Ile Arg Leu His Arg Ala Ala 
    50                  55                  60                  


Ile Tyr Thr Ala Glu Ile His Lys Ser Leu Ser Thr Asn Leu Asp Val 
65                  70                  75                  80  


Thr Asn Ser Ile Glu His Gln Val Lys Asp Val Leu Thr Pro Leu Phe 
                85                  90                  95      


Lys Ile Ile Gly Asp Glu Val Gly Leu Arg Thr Pro Gln Arg Phe Thr 
            100                 105                 110         


Asp Leu Val Lys Phe Ile Ser Asp Lys Ile Lys Phe Leu Asn Pro Asp 
        115                 120                 125             


Arg Glu Tyr Asp Phe Arg Asp Leu Thr Trp Cys Ile Asn Pro Pro Glu 
    130                 135                 140                 


Arg Ile Lys Leu Asp Tyr Asp Gln Tyr Cys Ala Asp Val Ala Ala Glu 
145                 150                 155                 160 


Glu Leu Met Asn Ala Leu Val Asn Ser Thr Leu Leu Glu Thr Arg Thr 
                165                 170                 175     


Thr Asn Gln Phe Leu Ala Val Ser Lys Gly Asn Cys Ser Gly Pro Thr 
            180                 185                 190         


Thr Ile Arg Gly Gln Phe Ser Asn Met Ser Leu Ser Leu Leu Asp Leu 
        195                 200                 205             


Tyr Leu Gly Arg Gly Tyr Asn Val Ser Ser Ile Val Thr Met Thr Ser 
    210                 215                 220                 


Gln Gly Met Tyr Gly Gly Thr Tyr Leu Val Glu Lys Pro Asn Leu Ser 
225                 230                 235                 240 


Ser Lys Arg Ser Glu Leu Ser Gln Leu Ser Met Tyr Arg Val Phe Glu 
                245                 250                 255     


Val Gly Val Ile Arg Asn Pro Gly Leu Gly Ala Pro Val Phe His Met 
            260                 265                 270         


Thr Asn Tyr Leu Glu Gln Pro Val Ser Asn Asp Leu Ser Asn Cys Met 
        275                 280                 285             


Val Ala Leu Gly Glu Leu Lys Leu Ala Ala Leu Cys His Gly Glu Asp 
    290                 295                 300                 


Ser Ile Thr Ile Pro Tyr Gln Gly Ser Gly Lys Gly Val Ser Phe Gln 
305                 310                 315                 320 


Leu Val Lys Leu Gly Val Trp Lys Ser Pro Thr Asp Met Gln Ser Trp 
                325                 330                 335     


Val Pro Leu Ser Thr Asp Asp Pro Val Ile Asp Arg Leu Tyr Leu Ser 
            340                 345                 350         


Ser His Arg Gly Val Ile Ala Asp Asn Gln Ala Lys Trp Ala Val Pro 
        355                 360                 365             


Thr Thr Arg Thr Asp Asp Lys Leu Arg Met Glu Thr Cys Phe Gln Gln 
    370                 375                 380                 


Ala Cys Lys Gly Lys Ile Gln Ala Leu Cys Glu Asn Pro Glu Trp Ala 
385                 390                 395                 400 


Pro Leu Lys Asp Asn Arg Ile Pro Ser Tyr Gly Val Leu Ser Val Asp 
                405                 410                 415     


Leu Ser Leu Thr Val Glu Leu Lys Ile Lys Ile Ala Ser Gly Phe Gly 
            420                 425                 430         


Pro Leu Ile Thr His Gly Ser Gly Met Asp Leu Tyr Lys Ser Asn His 
        435                 440                 445             


Asn Asn Val Tyr Trp Leu Thr Ile Pro Pro Met Lys Asn Leu Ala Leu 
    450                 455                 460                 


Gly Val Ile Asn Thr Leu Glu Trp Ile Pro Arg Phe Lys Val Ser Pro 
465                 470                 475                 480 


Tyr Leu Phe Asn Val Pro Ile Lys Glu Ala Gly Glu Asp Cys His Ala 
                485                 490                 495     


Pro Thr Tyr Leu Pro Ala Glu Val Asp Gly Asp Val Lys Leu Ser Ser 
            500                 505                 510         


Asn Leu Val Ile Leu Pro Gly Gln Asp Leu Gln Tyr Val Leu Ala Thr 
        515                 520                 525             


Tyr Asp Thr Ser Arg Val Glu His Ala Val Val Tyr Tyr Val Tyr Ser 
    530                 535                 540                 


Pro Ser Arg Ser Phe Ser Tyr Phe Tyr Pro Phe Arg Leu Pro Ile Lys 
545                 550                 555                 560 


Gly Val Pro Ile Glu Leu Gln Val Glu Cys Phe Thr Trp Asp Gln Lys 
                565                 570                 575     


Leu Trp Cys Arg His Phe Cys Val Leu Ala Asp Ser Glu Ser Gly Gly 
            580                 585                 590         


His Ile Thr His Ser Gly Met Glu Gly Met Gly Val Ser Cys Thr Val 
        595                 600                 605             


Thr Arg Glu Asp Gly Thr Asn Arg Arg 
    610                 615         


<210>  382
<211>  537
<212>  PRT
<213>  Phocine morbillivirus

<400>  382

Met Val Ile Leu Val His Cys Val Met Gly Gln Ile His Trp Thr Asn 
1               5                   10                  15      


Leu Ser Thr Ile Gly Ile Ile Gly Thr Asp Ser Ser His Tyr Lys Ile 
            20                  25                  30          


Met Thr Arg Ser Ser His Gln Tyr Leu Val Leu Lys Leu Met Pro Asn 
        35                  40                  45              


Val Ser Ile Ile Asp Asn Cys Thr Lys Ala Glu Leu Asp Glu Tyr Glu 
    50                  55                  60                  


Lys Leu Leu Asn Ser Val Leu Glu Pro Ile Asn Gln Ala Leu Thr Leu 
65                  70                  75                  80  


Met Thr Lys Asn Val Lys Ser Leu Gln Ser Leu Gly Ser Gly Arg Arg 
                85                  90                  95      


Gln Arg Arg Phe Ala Gly Val Val Ile Ala Gly Ala Ala Leu Gly Val 
            100                 105                 110         


Ala Thr Ala Ala Gln Ile Thr Ala Gly Val Ala Leu Tyr Gln Ser Asn 
        115                 120                 125             


Leu Asn Ala Gln Ala Ile Gln Ser Leu Arg Ala Ser Leu Glu Gln Ser 
    130                 135                 140                 


Asn Lys Ala Ile Asp Glu Val Arg Gln Ala Ser Gln Asn Ile Ile Ile 
145                 150                 155                 160 


Ala Val Gln Gly Val Gln Asp Tyr Val Asn Asn Glu Ile Val Pro Ala 
                165                 170                 175     


Leu Gln His Met Ser Cys Glu Leu Ile Gly Gln Arg Leu Gly Leu Lys 
            180                 185                 190         


Leu Leu Arg Tyr Tyr Thr Glu Leu Leu Ser Val Phe Gly Pro Ser Leu 
        195                 200                 205             


Arg Asp Pro Ile Ser Ala Glu Ile Ser Ile Gln Ala Leu Ser Tyr Ala 
    210                 215                 220                 


Leu Gly Gly Glu Ile His Lys Ile Leu Glu Lys Leu Gly Tyr Ser Gly 
225                 230                 235                 240 


Asn Asp Met Val Ala Ile Leu Glu Thr Lys Gly Ile Arg Ala Lys Ile 
                245                 250                 255     


Thr His Val Asp Leu Ser Gly Lys Phe Ile Val Leu Ser Ile Ser Tyr 
            260                 265                 270         


Pro Thr Leu Ser Glu Val Lys Gly Val Val Val His Arg Leu Glu Ala 
        275                 280                 285             


Val Ser Tyr Asn Ile Gly Ser Gln Glu Trp Tyr Thr Thr Val Pro Arg 
    290                 295                 300                 


Tyr Val Ala Thr Asn Gly Tyr Leu Ile Ser Asn Phe Asp Glu Ser Ser 
305                 310                 315                 320 


Cys Val Phe Val Ser Glu Ser Ala Ile Cys Ser Gln Asn Ser Leu Tyr 
                325                 330                 335     


Pro Met Ser Pro Ile Leu Gln Gln Cys Leu Arg Gly Glu Thr Ala Ser 
            340                 345                 350         


Cys Ala Arg Thr Leu Val Ser Gly Thr Leu Gly Asn Lys Phe Ile Leu 
        355                 360                 365             


Ser Lys Gly Asn Ile Ile Ala Asn Cys Ala Ser Ile Leu Cys Lys Cys 
    370                 375                 380                 


His Ser Thr Ser Lys Ile Ile Asn Gln Ser Pro Asp Lys Leu Leu Thr 
385                 390                 395                 400 


Phe Ile Ala Ser Asp Thr Cys Ser Leu Val Glu Ile Asp Gly Val Thr 
                405                 410                 415     


Ile Gln Val Gly Ser Arg Gln Tyr Pro Asp Val Val Tyr Ala Ser Lys 
            420                 425                 430         


Val Ile Leu Gly Pro Ala Ile Ser Leu Glu Arg Leu Asp Val Gly Thr 
        435                 440                 445             


Asn Leu Gly Ser Ala Leu Lys Lys Leu Asp Asp Ala Lys Val Leu Ile 
    450                 455                 460                 


Glu Ser Ser Asp Gln Ile Leu Asp Thr Val Lys Asn Ser Tyr Leu Ser 
465                 470                 475                 480 


Leu Gly Thr Leu Ile Ala Leu Pro Val Ser Ile Gly Leu Gly Leu Ile 
                485                 490                 495     


Leu Leu Leu Leu Ile Cys Cys Cys Lys Lys Arg Tyr Gln His Leu Phe 
            500                 505                 510         


Ser Gln Ser Thr Lys Val Ala Pro Val Phe Lys Pro Asp Leu Thr Gly 
        515                 520                 525             


Thr Ser Lys Ser Tyr Val Arg Ser Leu 
    530                 535         


<210>  383
<211>  607
<212>  PRT
<213>  Phocine morbillivirus

<400>  383

Met Phe Ser His Gln Asp Lys Val Gly Ala Phe Tyr Lys Asn Asn Ala 
1               5                   10                  15      


Arg Ala Asn Ser Ser Lys Leu Ser Leu Val Thr Asp Glu Val Glu Glu 
            20                  25                  30          


Arg Arg Ser Pro Trp Phe Leu Ser Ile Leu Leu Ile Leu Leu Val Gly 
        35                  40                  45              


Ile Leu Ile Leu Leu Thr Ile Thr Gly Ile Arg Phe His Gln Val Val 
    50                  55                  60                  


Lys Ser Asn Leu Glu Phe Asn Lys Leu Leu Ile Glu Asp Met Glu Lys 
65                  70                  75                  80  


Thr Glu Ala Val His His Gln Val Lys Asp Val Leu Thr Pro Leu Phe 
                85                  90                  95      


Lys Ile Ile Gly Asp Glu Val Gly Leu Arg Leu Pro Gln Lys Leu Asn 
            100                 105                 110         


Glu Ile Lys Gln Phe Ile Val Gln Lys Thr Asn Phe Phe Asn Pro Asn 
        115                 120                 125             


Arg Glu Phe Asp Phe Arg Glu Leu His Trp Cys Ile Asn Pro Pro Ser 
    130                 135                 140                 


Lys Val Lys Val Asn Phe Thr Gln Tyr Cys Glu Ile Thr Glu Phe Lys 
145                 150                 155                 160 


Glu Ala Thr Arg Ser Val Ala Asn Ser Ile Leu Leu Leu Thr Leu Tyr 
                165                 170                 175     


Arg Gly Arg Asp Asp Ile Phe Pro Pro Tyr Lys Cys Arg Gly Ala Thr 
            180                 185                 190         


Thr Ser Met Gly Asn Val Phe Pro Leu Ala Val Ser Leu Ser Met Ser 
        195                 200                 205             


Leu Ile Ser Lys Pro Ser Glu Val Ile Asn Met Leu Thr Ala Ile Ser 
    210                 215                 220                 


Glu Gly Ile Tyr Gly Lys Thr Tyr Leu Leu Val Thr Asp Asp Thr Glu 
225                 230                 235                 240 


Glu Asn Phe Glu Thr Pro Glu Ile Arg Val Phe Glu Ile Gly Phe Ile 
                245                 250                 255     


Asn Arg Trp Leu Gly Asp Met Pro Leu Phe Gln Thr Thr Asn Tyr Arg 
            260                 265                 270         


Ile Ile Ser Asn Asn Ser Asn Thr Lys Ile Cys Thr Ile Ala Val Gly 
        275                 280                 285             


Glu Leu Ala Leu Ala Ser Leu Cys Thr Lys Glu Ser Thr Ile Leu Pro 
    290                 295                 300                 


Asn Leu Gly Asp Glu Glu Ser Gln Asn Ser Val Leu Val Val Ile Leu 
305                 310                 315                 320 


Gly Leu Phe Gly Ala Thr His Met Asp Gln Leu Glu Glu Val Ile Pro 
                325                 330                 335     


Val Ala His Pro Ser Ile Glu Lys Ile His Ile Thr Asn His Arg Gly 
            340                 345                 350         


Phe Ile Lys Asp Ser Val Ala Thr Trp Met Val Pro Ala Leu Ala Leu 
        355                 360                 365             


Ser Glu Gln Gly Glu Gln Ile Asn Cys Leu Ser Ser Ala Cys Lys Arg 
    370                 375                 380                 


Arg Thr Tyr Pro Met Cys Asn Gln Thr Ser Trp Glu Pro Phe Gly Asp 
385                 390                 395                 400 


Lys Arg Leu Pro Ser Tyr Gly Arg Leu Thr Leu Ser Leu Asp Val Ser 
                405                 410                 415     


Thr Asp Leu Ser Ile Asn Val Ser Val Ala Gln Gly Pro Ile Ile Phe 
            420                 425                 430         


Asn Gly Asp Gly Met Asp Tyr Tyr Glu Gly Thr Leu Leu Asn Ser Gly 
        435                 440                 445             


Trp Leu Thr Ile Pro Pro Lys Asn Gly Thr Ile Leu Gly Leu Ile Asn 
    450                 455                 460                 


Gln Ala Ser Lys Gly Asp Gln Phe Ile Val Thr Pro His Ile Leu Thr 
465                 470                 475                 480 


Phe Ala Pro Arg Glu Ser Ser Thr Asp Cys His Leu Pro Ile Gln Thr 
                485                 490                 495     


Tyr Gln Ile Gln Asp Asp Asp Val Leu Leu Glu Ser Asn Leu Val Val 
            500                 505                 510         


Leu Pro Thr Gln Ser Phe Glu Tyr Val Val Ala Thr Tyr Asp Val Ser 
        515                 520                 525             


Arg Ser Asp His Ala Ile Val Tyr Tyr Val Tyr Asp Pro Ala Arg Thr 
    530                 535                 540                 


Val Ser Tyr Thr Tyr Pro Phe Arg Leu Arg Thr Lys Gly Arg Pro Asp 
545                 550                 555                 560 


Ile Leu Arg Ile Glu Cys Phe Val Trp Asp Gly His Leu Trp Cys His 
                565                 570                 575     


Gln Phe Tyr Arg Phe Gln Leu Asp Ala Thr Asn Ser Thr Ser Val Val 
            580                 585                 590         


Glu Asn Leu Ile Arg Ile Arg Phe Ser Cys Asp Arg Leu Asp Pro 
        595                 600                 605         


<210>  384
<211>  546
<212>  PRT
<213>  Rinderpest morbillivirus

<400>  384

Met Lys Ile Leu Phe Ala Thr Leu Leu Val Val Thr Thr Pro His Leu 
1               5                   10                  15      


Val Thr Gly Gln Ile His Trp Gly Asn Leu Ser Lys Ile Gly Val Val 
            20                  25                  30          


Gly Thr Gly Ser Ala Ser Tyr Lys Val Met Thr Gln Ser Ser His Gln 
        35                  40                  45              


Thr Leu Val Ile Lys Leu Met Pro Asn Ile Thr Ala Ile Asp Asn Cys 
    50                  55                  60                  


Thr Lys Thr Glu Ile Glu Glu Tyr Lys Arg Leu Leu Gly Thr Val Leu 
65                  70                  75                  80  


Gln Pro Ile Lys Val Ala Leu Asn Ala Ile Thr Lys Asn Ile Lys Pro 
                85                  90                  95      


Ile Lys Ser Ser Thr Thr Ser Arg Arg His Arg Arg Phe Ala Gly Val 
            100                 105                 110         


Ala Leu Ala Gly Ala Ala Leu Gly Val Ala Thr Ala Ala Gln Ile Thr 
        115                 120                 125             


Ala Gly Ile Ala Leu His Gln Ser Met Met Asn Thr Gln Ala Ile Glu 
    130                 135                 140                 


Ser Leu Lys Ala Ser Leu Glu Thr Thr Asn Gln Ala Ile Glu Glu Ile 
145                 150                 155                 160 


Arg Gln Ala Gly Gln Glu Met Ile Leu Ala Val Gln Gly Val Gln Asp 
                165                 170                 175     


Tyr Ile Asn Asn Glu Leu Val Pro Ala Met Gly Gln Leu Ser Cys Asp 
            180                 185                 190         


Ile Val Gly Gln Lys Leu Gly Leu Lys Leu Leu Arg Tyr Tyr Thr Glu 
        195                 200                 205             


Ile Leu Ser Leu Phe Gly Pro Ser Leu Arg Asp Pro Ile Ser Ala Glu 
    210                 215                 220                 


Ile Ser Ile Gln Ala Leu Ser Tyr Ala Leu Gly Gly Asp Ile Asn Lys 
225                 230                 235                 240 


Ile Leu Glu Lys Leu Gly Tyr Ser Gly Ser Asp Leu Leu Ala Ile Leu 
                245                 250                 255     


Glu Ser Lys Gly Ile Lys Ala Lys Ile Thr Tyr Val Asp Ile Glu Ser 
            260                 265                 270         


Tyr Phe Ile Val Leu Ser Ile Ala Tyr Pro Ser Leu Ser Glu Ile Lys 
        275                 280                 285             


Gly Val Ile Ile His Arg Leu Glu Gly Val Ser Tyr Asn Ile Gly Ser 
    290                 295                 300                 


Gln Glu Trp Tyr Thr Thr Val Pro Arg Tyr Val Ala Thr Gln Gly Tyr 
305                 310                 315                 320 


Leu Ile Ser Asn Phe Asp Asp Thr Pro Cys Ala Phe Ser Pro Glu Gly 
                325                 330                 335     


Thr Ile Cys Ser Gln Asn Ala Leu Tyr Pro Met Ser Pro Leu Leu Gln 
            340                 345                 350         


Glu Cys Phe Arg Gly Ser Thr Arg Ser Cys Ala Arg Thr Leu Val Ser 
        355                 360                 365             


Gly Ser Ile Gly Asn Arg Phe Ile Leu Ser Lys Gly Asn Leu Ile Ala 
    370                 375                 380                 


Asn Cys Ala Ser Ile Leu Cys Lys Cys Tyr Thr Thr Gly Ser Ile Ile 
385                 390                 395                 400 


Ser Gln Asp Pro Asp Lys Ile Leu Thr Tyr Ile Ala Ala Asp Gln Cys 
                405                 410                 415     


Pro Ile Val Glu Val Asp Gly Val Thr Ile Gln Val Gly Ser Arg Glu 
            420                 425                 430         


Tyr Pro Asp Ala Val Tyr Leu His Lys Ile Asp Leu Gly Pro Pro Ile 
        435                 440                 445             


Ser Leu Glu Lys Leu Asp Val Gly Thr Asn Leu Gly Asn Ala Val Thr 
    450                 455                 460                 


Lys Leu Glu Lys Ala Lys Asp Leu Leu Asp Ser Ser Asp Leu Ile Leu 
465                 470                 475                 480 


Glu Thr Ile Lys Gly Ala Ser Val Thr Asn Thr Gly His Ile Leu Val 
                485                 490                 495     


Gly Ala Gly Leu Ile Ala Val Val Gly Ile Leu Ile Val Thr Cys Cys 
            500                 505                 510         


Cys Arg Lys Arg Ser Asn Asp Ser Lys Val Ser Thr Val Ile Leu Asn 
        515                 520                 525             


Pro Gly Leu Lys Pro Asp Leu Thr Gly Thr Ser Lys Ser Tyr Val Arg 
    530                 535                 540                 


Ser Leu 
545     


<210>  385
<211>  609
<212>  PRT
<213>  Rinderpest morbillivirus

<400>  385

Met Ser Pro Pro Arg Asp Arg Val Asp Ala Tyr Tyr Lys Asp Asn Phe 
1               5                   10                  15      


Gln Phe Lys Asn Thr Arg Val Val Leu Asn Lys Glu Gln Leu Leu Ile 
            20                  25                  30          


Glu Arg Pro Cys Met Leu Leu Thr Val Leu Phe Val Met Phe Leu Ser 
        35                  40                  45              


Leu Val Gly Leu Leu Ala Ile Ala Gly Ile Arg Leu His Arg Ala Ala 
    50                  55                  60                  


Val Asn Thr Ala Lys Ile Asn Asn Asp Leu Thr Thr Ser Ile Asp Ile 
65                  70                  75                  80  


Thr Lys Ser Ile Glu Tyr Gln Val Lys Asp Val Leu Thr Pro Leu Phe 
                85                  90                  95      


Lys Ile Ile Gly Asp Glu Val Gly Leu Arg Thr Pro Gln Arg Phe Thr 
            100                 105                 110         


Asp Leu Thr Lys Phe Ile Ser Asp Lys Ile Lys Phe Leu Asn Pro Asp 
        115                 120                 125             


Lys Glu Tyr Asp Phe Arg Asp Ile Asn Trp Cys Ile Asn Pro Pro Glu 
    130                 135                 140                 


Arg Ile Lys Ile Asp Tyr Asp Gln Tyr Cys Ala His Thr Ala Ala Glu 
145                 150                 155                 160 


Asp Leu Ile Thr Met Leu Val Asn Ser Ser Leu Thr Gly Thr Thr Val 
                165                 170                 175     


Pro Arg Thr Ser Leu Val Asn Leu Gly Arg Asn Cys Thr Gly Pro Thr 
            180                 185                 190         


Thr Thr Lys Gly Gln Phe Ser Asn Ile Ser Leu Thr Leu Ser Gly Ile 
        195                 200                 205             


Tyr Ser Gly Arg Gly Tyr Asn Ile Ser Ser Met Ile Thr Ile Thr Gly 
    210                 215                 220                 


Lys Gly Met Tyr Gly Ser Thr Tyr Leu Val Gly Lys Tyr Asn Gln Arg 
225                 230                 235                 240 


Ala Arg Arg Pro Ser Lys Val Trp His Gln Asp Tyr Arg Val Phe Glu 
                245                 250                 255     


Val Gly Ile Ile Arg Glu Leu Gly Val Gly Thr Pro Gly Phe His Met 
            260                 265                 270         


Thr Asn Tyr Leu Glu Leu Pro Arg Gln Pro Glu Leu Glu Thr Cys Met 
        275                 280                 285             


Leu Ala Leu Gly Glu Ser Lys Leu Ala Ala Leu Cys Leu Ala Asp Ser 
    290                 295                 300                 


Pro Val Ala Leu His Tyr Gly Arg Val Gly Asp Asp Asn Lys Ile Arg 
305                 310                 315                 320 


Phe Val Lys Leu Gly Val Trp Ala Ser Pro Ala Asp Arg Asp Thr Leu 
                325                 330                 335     


Ala Thr Leu Ser Ala Ile Asp Pro Thr Leu Asp Gly Leu Tyr Ile Thr 
            340                 345                 350         


Thr His Arg Gly Ile Ile Ala Ala Gly Thr Ala Ile Trp Ala Val Pro 
        355                 360                 365             


Val Thr Arg Thr Asp Asp Gln Val Lys Met Gly Lys Cys Arg Leu Glu 
    370                 375                 380                 


Ala Cys Arg Asp Arg Pro Pro Pro Phe Cys Asn Ser Thr Asp Trp Glu 
385                 390                 395                 400 


Pro Leu Glu Ala Gly Arg Ile Pro Ala Tyr Gly Val Leu Thr Ile Lys 
                405                 410                 415     


Leu Gly Leu Ala Asp Glu Pro Lys Val Asp Ile Ile Ser Glu Phe Gly 
            420                 425                 430         


Pro Leu Ile Thr His Asp Ser Gly Met Asp Leu Tyr Thr Ser Phe Asp 
        435                 440                 445             


Gly Thr Lys Tyr Trp Leu Thr Thr Pro Pro Leu Gln Asn Ser Ala Leu 
    450                 455                 460                 


Gly Thr Val Asn Thr Leu Val Leu Glu Pro Ser Leu Lys Ile Ser Pro 
465                 470                 475                 480 


Asn Ile Leu Thr Leu Pro Ile Arg Ser Gly Gly Gly Asp Cys Tyr Ile 
                485                 490                 495     


Pro Thr Tyr Leu Ser Asp Arg Ala Asp Asp Asp Val Lys Leu Ser Ser 
            500                 505                 510         


Asn Leu Val Ile Leu Pro Ser Arg Asp Leu Gln Tyr Val Ser Ala Thr 
        515                 520                 525             


Tyr Asp Ile Ser Arg Val Glu His Ala Ile Val Tyr His Ile Tyr Ser 
    530                 535                 540                 


Thr Gly Arg Leu Ser Ser Tyr Tyr Tyr Pro Phe Lys Leu Pro Ile Lys 
545                 550                 555                 560 


Gly Asp Pro Val Ser Leu Gln Ile Glu Cys Phe Pro Trp Asp Arg Lys 
                565                 570                 575     


Leu Trp Cys His His Phe Cys Ser Val Val Asp Ser Gly Thr Gly Glu 
            580                 585                 590         


Gln Val Thr His Ile Gly Val Val Gly Ile Lys Ile Thr Cys Asn Gly 
        595                 600                 605             


Lys 
    


<210>  386
<211>  546
<212>  PRT
<213>  Small ruminant morbillivirus

<400>  386

Met Thr Arg Val Ala Ile Leu Thr Ser Leu Phe Leu Leu Pro Asn Val 
1               5                   10                  15      


Val Ala Cys Gln Ile His Trp Gly Asn Leu Ser Lys Ile Gly Ile Val 
            20                  25                  30          


Gly Thr Gly Ser Ala Ser Tyr Lys Val Met Thr Arg Pro Ser His Gln 
        35                  40                  45              


Thr Leu Val Ile Lys Leu Met Pro Asn Ile Thr Ala Ile Asp Asn Cys 
    50                  55                  60                  


Thr Lys Ser Glu Ile Ala Glu Tyr Lys Arg Leu Leu Ile Thr Val Leu 
65                  70                  75                  80  


Lys Pro Val Glu Asp Ala Leu Ser Val Ile Thr Lys Asn Val Arg Pro 
                85                  90                  95      


Ile Gln Thr Leu Thr Pro Gly Arg Arg Thr Arg Arg Phe Ala Gly Ala 
            100                 105                 110         


Val Leu Ala Gly Val Ala Leu Gly Val Ala Thr Ala Ala Gln Ile Thr 
        115                 120                 125             


Ala Gly Val Ala Leu His Gln Ser Leu Met Asn Ser Gln Ala Ile Glu 
    130                 135                 140                 


Ser Leu Lys Thr Ser Leu Glu Lys Ser Asn Gln Ala Ile Glu Glu Ile 
145                 150                 155                 160 


Arg Leu Ala Asn Lys Glu Thr Ile Leu Ala Val Gln Gly Val Gln Asp 
                165                 170                 175     


Tyr Ile Asn Asn Glu Leu Val Pro Ser Val His Arg Met Ser Cys Glu 
            180                 185                 190         


Leu Val Gly His Lys Leu Gly Leu Lys Leu Leu Arg Tyr Tyr Thr Glu 
        195                 200                 205             


Ile Leu Ser Ile Phe Gly Pro Ser Leu Arg Asp Pro Ile Ala Ala Glu 
    210                 215                 220                 


Ile Ser Ile Gln Ala Leu Ser Tyr Ala Leu Gly Gly Asp Ile Asn Lys 
225                 230                 235                 240 


Ile Leu Asp Lys Leu Gly Tyr Ser Gly Gly Asp Phe Leu Ala Ile Leu 
                245                 250                 255     


Glu Ser Lys Gly Ile Lys Ala Arg Val Thr Tyr Val Asp Thr Arg Asp 
            260                 265                 270         


Tyr Phe Ile Met Leu Ser Ile Ala Tyr Pro Thr Leu Ser Glu Ile Lys 
        275                 280                 285             


Gly Val Ile Val His Lys Ile Glu Ala Ile Thr Tyr Asn Ile Gly Ala 
    290                 295                 300                 


Gln Glu Trp Tyr Thr Thr Ile Pro Lys Tyr Val Ala Thr Gln Gly Tyr 
305                 310                 315                 320 


Leu Ile Ser Asn Phe Asp Glu Thr Ser Cys Val Phe Thr Pro Glu Gly 
                325                 330                 335     


Thr Val Cys Ser Gln Asn Ala Leu Tyr Pro Met Ser Pro Leu Leu Gln 
            340                 345                 350         


Glu Cys Phe Arg Gly Ser Thr Lys Ser Cys Ala Arg Thr Leu Val Ser 
        355                 360                 365             


Gly Thr Ile Ser Asn Arg Phe Ile Leu Ser Lys Gly Asn Leu Ile Ala 
    370                 375                 380                 


Asn Cys Ala Ser Val Leu Cys Lys Cys Tyr Thr Thr Glu Thr Val Ile 
385                 390                 395                 400 


Ser Gln Asp Pro Asp Lys Leu Leu Thr Val Val Ala Ser Asp Lys Cys 
                405                 410                 415     


Pro Val Val Glu Val Asp Gly Val Thr Ile Gln Val Gly Ser Arg Glu 
            420                 425                 430         


Tyr Pro Asp Ser Val Tyr Leu His Lys Ile Asp Leu Gly Pro Ala Ile 
        435                 440                 445             


Ser Leu Glu Lys Leu Asp Val Gly Thr Asn Leu Gly Asn Ala Val Thr 
    450                 455                 460                 


Arg Leu Glu Asn Ala Lys Glu Leu Leu Asp Ala Ser Asp Gln Ile Leu 
465                 470                 475                 480 


Lys Thr Val Lys Gly Ala Pro Phe Gly Gly Asn Met Tyr Ile Ala Leu 
                485                 490                 495     


Ala Ala Cys Ile Gly Val Ser Leu Gly Leu Val Thr Leu Ile Cys Cys 
            500                 505                 510         


Cys Lys Gly Arg Cys Lys Asn Lys Glu Ile Pro Ile Ser Lys Ile Asn 
        515                 520                 525             


Pro Gly Leu Lys Pro Asp Leu Thr Gly Thr Ser Lys Ser Tyr Val Arg 
    530                 535                 540                 


Ser Leu 
545     


<210>  387
<211>  609
<212>  PRT
<213>  Small ruminant morbillivirus

<400>  387

Met Ser Ala Gln Arg Glu Arg Val Asn Ala Phe Tyr Lys Asp Asn Pro 
1               5                   10                  15      


His Asn Lys Asn His Arg Val Ile Leu Asp Arg Glu Arg Leu Val Ile 
            20                  25                  30          


Glu Arg Pro Tyr Ile Leu Leu Gly Val Leu Leu Val Met Phe Leu Ser 
        35                  40                  45              


Leu Ile Gly Leu Leu Ala Ile Ala Gly Ile Arg Leu His Arg Ala Thr 
    50                  55                  60                  


Val Gly Thr Ser Glu Ile Gln Ser Arg Leu Asn Thr Asn Ile Glu Leu 
65                  70                  75                  80  


Thr Glu Ser Ile Asp His Gln Thr Lys Asp Val Leu Thr Pro Leu Phe 
                85                  90                  95      


Lys Ile Ile Gly Asp Glu Val Gly Ile Arg Ile Pro Gln Lys Phe Ser 
            100                 105                 110         


Asp Leu Val Lys Phe Ile Ser Asp Lys Ile Lys Phe Leu Asn Pro Asp 
        115                 120                 125             


Arg Glu Tyr Asp Phe Arg Asp Leu Arg Trp Cys Met Asn Pro Pro Glu 
    130                 135                 140                 


Arg Val Lys Ile Asn Phe Asp Gln Phe Cys Glu Tyr Lys Ala Ala Ala 
145                 150                 155                 160 


Lys Ser Ile Glu His Ile Phe Glu Ser Pro Leu Asn Lys Ser Lys Lys 
                165                 170                 175     


Leu Gln Ser Leu Thr Leu Gly Pro Gly Ser Gly Cys Leu Gly Arg Thr 
            180                 185                 190         


Val Thr Arg Ala His Phe Ser Glu Leu Thr Leu Thr Leu Met Asp Leu 
        195                 200                 205             


Asp Leu Glu Lys Lys His Asn Val Ser Ser Val Phe Thr Val Val Glu 
    210                 215                 220                 


Glu Gly Leu Phe Gly Arg Thr Tyr Thr Val Trp Arg Phe Asp Ala Arg 
225                 230                 235                 240 


Asp Pro Ser Thr Asp Leu Gly Ile Gly His Phe Leu Arg Val Phe Glu 
                245                 250                 255     


Ile Gly Leu Val Arg Asp Leu Gly Leu Gly Pro Pro Val Phe Gln Met 
            260                 265                 270         


Thr Asn Tyr Leu Thr Val Asn Met Ser Asp Asp Tyr Arg Arg Cys Leu 
        275                 280                 285             


Leu Ala Val Gly Glu Leu Lys Leu Thr Ala Leu Cys Thr Ser Ser Glu 
    290                 295                 300                 


Thr Val Thr Leu Asn Glu Gly Gly Val Pro Lys Arg Glu Ser Leu Ala 
305                 310                 315                 320 


Val Val Ile Leu Asn Leu Ala Gly Pro Thr Leu Gly Gly Glu Leu Tyr 
                325                 330                 335     


Ser Val Leu Pro Ile Ser Asp Leu Met Val Glu Lys Leu Tyr Leu Ser 
            340                 345                 350         


Ser His Arg Gly Val Ile Lys Asp Asp Glu Ala Asn Trp Val Val Pro 
        355                 360                 365             


Ser Thr Asp Val Arg Asp Leu Gln Asn Lys Gly Glu Cys Leu Val Glu 
    370                 375                 380                 


Ala Cys Lys Thr Arg Pro Pro Ser Phe Cys Asn Gly Thr Gly Ser Gly 
385                 390                 395                 400 


Pro Trp Ser Glu Gly Arg Ile Pro Ala Tyr Gly Val Ile Arg Val Ser 
                405                 410                 415     


Leu Asp Leu Ala Ser Asp Pro Gly Val Val Ile Thr Ser Ala Phe Gly 
            420                 425                 430         


Pro Leu Ile Pro His Leu Ser Gly Met Asp Leu Tyr Asn Asn Pro Phe 
        435                 440                 445             


Ser Arg Ala Val Trp Leu Ala Val Pro Pro Tyr Glu Gln Ser Phe Leu 
    450                 455                 460                 


Gly Met Ile Asn Thr Ile Gly Phe Pro Asp Arg Ala Glu Val Met Pro 
465                 470                 475                 480 


His Ile Leu Thr Thr Glu Ile Arg Gly Pro Arg Gly Arg Cys His Val 
                485                 490                 495     


Pro Ile Glu Leu Ser His Arg Val Asp Asp Asp Ile Lys Ile Gly Ser 
            500                 505                 510         


Asn Met Val Ile Leu Pro Thr Met Asp Leu Arg Tyr Ile Thr Ala Thr 
        515                 520                 525             


Tyr Asp Val Ser Arg Ser Glu His Ala Ile Val Tyr Tyr Ile Tyr Asp 
    530                 535                 540                 


Thr Gly Arg Ser Ser Ser Tyr Phe Tyr Pro Val Arg Leu Asn Phe Lys 
545                 550                 555                 560 


Gly Asn Pro Leu Ser Leu Arg Ile Glu Cys Phe Pro Trp Arg His Lys 
                565                 570                 575     


Val Trp Cys Tyr His Asp Cys Leu Ile Tyr Asn Thr Ile Thr Asp Glu 
            580                 585                 590         


Glu Val His Ala Arg Gly Leu Thr Gly Ile Glu Val Thr Cys Asn Pro 
        595                 600                 605             


Val 
    


<210>  388
<211>  552
<212>  PRT
<213>  Mossman narmovirus

<400>  388

Met Ser Asn Tyr Phe Pro Ala Arg Val Ile Ile Ile Val Ser Leu Ile 
1               5                   10                  15      


Thr Ala Val Ser Cys Gln Ile Ser Phe Gln Asn Leu Ser Thr Ile Gly 
            20                  25                  30          


Val Phe Lys Phe Lys Glu Tyr Asp Tyr Arg Val Ser Gly Asp Tyr Asn 
        35                  40                  45              


Glu Gln Phe Leu Ala Ile Lys Met Val Pro Asn Val Thr Gly Val Glu 
    50                  55                  60                  


Asn Cys Thr Ala Ser Leu Ile Asp Glu Tyr Arg His Val Ile Tyr Asn 
65                  70                  75                  80  


Leu Leu Gln Pro Ile Asn Thr Thr Leu Thr Ala Ser Thr Ser Asn Val 
                85                  90                  95      


Asp Pro Tyr Ala Gly Asn Lys Lys Phe Phe Gly Ala Val Ile Ala Gly 
            100                 105                 110         


Val Ala Leu Gly Val Ala Thr Ala Ala Gln Val Thr Ala Gly Val Ala 
        115                 120                 125             


Leu Tyr Glu Ala Arg Gln Asn Ala Ala Ala Ile Ala Glu Ile Lys Glu 
    130                 135                 140                 


Ser Leu His Tyr Thr His Lys Ala Ile Glu Ser Leu Gln Ile Ser Gln 
145                 150                 155                 160 


Lys Gln Thr Val Val Ala Ile Gln Gly Ile Gln Asp Gln Ile Asn Thr 
                165                 170                 175     


Asn Ile Ile Pro Gln Ile Asn Ala Leu Thr Cys Glu Ile Ala Asn Gln 
            180                 185                 190         


Arg Leu Arg Leu Met Leu Leu Gln Tyr Tyr Thr Glu Met Leu Ser Ser 
        195                 200                 205             


Phe Gly Pro Ile Ile Gln Asp Pro Leu Ser Gly His Ile Thr Val Gln 
    210                 215                 220                 


Ala Leu Ser Gln Ala Ala Gly Gly Asn Ile Thr Gly Leu Met Arg Glu 
225                 230                 235                 240 


Leu Gly Tyr Ser Ser Lys Asp Leu Arg Tyr Ile Leu Ser Val Asn Gly 
                245                 250                 255     


Ile Ser Ala Asn Ile Ile Asp Ala Asp Pro Glu Ile Gly Ser Ile Ile 
            260                 265                 270         


Leu Arg Ile Arg Tyr Pro Ser Met Ile Lys Ile Pro Asp Val Ala Val 
        275                 280                 285             


Met Glu Leu Ser Tyr Leu Ala Tyr His Ala Ala Gly Gly Asp Trp Leu 
    290                 295                 300                 


Thr Val Gly Pro Arg Phe Ile Leu Lys Arg Gly Tyr Ser Leu Ser Asn 
305                 310                 315                 320 


Leu Asp Ile Thr Ser Cys Thr Ile Gly Glu Asp Phe Leu Leu Cys Ser 
                325                 330                 335     


Lys Asp Val Ser Ser Pro Met Ser Leu Ala Thr Gln Ser Cys Leu Arg 
            340                 345                 350         


Gly Asp Thr Gln Met Cys Ser Arg Thr Ala Val Gln Asp Arg Glu Ala 
        355                 360                 365             


Pro Arg Phe Leu Leu Leu Gln Gly Asn Leu Ile Val Asn Cys Met Ser 
    370                 375                 380                 


Val Asn Cys Lys Cys Glu Asp Pro Glu Glu Thr Ile Thr Gln Asp Pro 
385                 390                 395                 400 


Ala Tyr Pro Leu Met Val Leu Gly Ser Asp Thr Cys Lys Ile His Tyr 
                405                 410                 415     


Ile Asp Gly Ile Arg Ile Lys Leu Gly Lys Val Gln Leu Pro Pro Ile 
            420                 425                 430         


Thr Val Leu Asn Thr Leu Ser Leu Gly Pro Ile Val Val Leu Asn Pro 
        435                 440                 445             


Ile Asp Val Ser Asn Gln Leu Ser Leu Val Glu Thr Thr Val Lys Glu 
    450                 455                 460                 


Ser Glu Asp His Leu Lys Asn Ala Ile Gly Ala Leu Arg Ser Gln Ser 
465                 470                 475                 480 


Arg Val Gly Gly Val Gly Ile Val Ala Ile Val Gly Leu Ile Ile Ala 
                485                 490                 495     


Thr Val Ser Leu Val Val Leu Val Ile Ser Gly Cys Cys Leu Val Lys 
            500                 505                 510         


Tyr Phe Ser Arg Thr Ala Thr Leu Glu Ser Ser Leu Thr Thr Ile Glu 
        515                 520                 525             


His Gly Pro Thr Leu Ala Pro Lys Ser Gly Pro Ile Ile Pro Thr Tyr 
    530                 535                 540                 


Ile Asn Pro Val Tyr Arg His Asp 
545                 550         


<210>  389
<211>  632
<212>  PRT
<213>  Mossman narmovirus

<400>  389

Met Val Asp Pro Pro Ala Val Ser Tyr Tyr Thr Gly Thr Gly Arg Asn 
1               5                   10                  15      


Asp Arg Val Lys Val Val Thr Thr Gln Ser Thr Asn Pro Tyr Trp Ala 
            20                  25                  30          


His Asn Pro Asn Gln Gly Leu Arg Arg Leu Ile Asp Met Val Val Asn 
        35                  40                  45              


Val Ile Met Val Thr Gly Val Ile Phe Ala Leu Ile Asn Ile Ile Leu 
    50                  55                  60                  


Gly Ile Val Ile Ile Ser Gln Ser Ala Gly Ser Arg Gln Asp Thr Ser 
65                  70                  75                  80  


Lys Ser Leu Asp Ile Ile Gln His Val Asp Ser Ser Val Ala Ile Thr 
                85                  90                  95      


Lys Gln Ile Val Met Glu Asn Leu Glu Pro Lys Ile Arg Ser Ile Leu 
            100                 105                 110         


Asp Ser Val Ser Phe Gln Ile Pro Lys Leu Leu Ser Ser Leu Leu Gly 
        115                 120                 125             


Pro Gly Lys Thr Asp Pro Pro Ile Ala Leu Pro Thr Lys Ala Ser Thr 
    130                 135                 140                 


Pro Val Ile Pro Thr Glu Tyr Pro Ser Leu Asn Thr Thr Thr Cys Leu 
145                 150                 155                 160 


Arg Ile Glu Glu Ser Val Thr Gln Asn Ala Ala Ala Leu Phe Asn Ile 
                165                 170                 175     


Ser Phe Asp Leu Lys Thr Val Met Tyr Glu Leu Val Thr Arg Thr Gly 
            180                 185                 190         


Gly Cys Val Thr Leu Pro Ser Tyr Ser Glu Leu Tyr Thr Arg Val Arg 
        195                 200                 205             


Thr Phe Ser Thr Ala Ile Arg Asn Pro Lys Thr Cys Gln Arg Ala Gly 
    210                 215                 220                 


Gln Glu Thr Asp Leu Asn Leu Ile Pro Ala Phe Ile Gly Thr Asp Thr 
225                 230                 235                 240 


Gly Ile Leu Ile Asn Ser Cys Val Arg Gln Pro Val Ile Ala Thr Gly 
                245                 250                 255     


Asp Gly Ile Tyr Ala Leu Thr Tyr Leu Thr Met Arg Gly Thr Cys Gln 
            260                 265                 270         


Asp His Arg His Ala Val Arg His Phe Glu Ile Gly Leu Val Arg Arg 
        275                 280                 285             


Asp Ala Trp Trp Asp Pro Val Leu Thr Pro Ile His His Phe Thr Glu 
    290                 295                 300                 


Pro Gly Thr Pro Val Phe Asp Gly Cys Ser Leu Thr Val Gln Asn Gln 
305                 310                 315                 320 


Thr Ala Leu Ala Leu Cys Thr Leu Thr Thr Asp Gly Pro Glu Thr Asp 
                325                 330                 335     


Ile His Asn Gly Ala Ser Leu Gly Leu Ala Leu Val His Phe Asn Ile 
            340                 345                 350         


Arg Gly Glu Phe Ser Lys His Lys Val Asp Pro Arg Asn Ile Asp Thr 
        355                 360                 365             


Gln Asn Gln Gly Leu His Leu Val Thr Thr Ala Gly Lys Ser Ala Val 
    370                 375                 380                 


Lys Lys Gly Ile Leu Tyr Ser Phe Gly Tyr Met Val Thr Arg Ser Pro 
385                 390                 395                 400 


Glu Pro Gly Asp Ser Lys Cys Val Thr Glu Glu Cys Asn Gln Asn Asn 
                405                 410                 415     


Gln Glu Lys Cys Asn Ala Tyr Ser Lys Thr Thr Leu Asp Pro Asp Lys 
            420                 425                 430         


Pro Arg Ser Met Ile Ile Phe Gln Ile Asp Val Gly Ala Glu Tyr Phe 
        435                 440                 445             


Thr Val Asp Lys Val Val Val Val Pro Arg Thr Gln Tyr Tyr Gln Leu 
    450                 455                 460                 


Thr Ser Gly Asp Leu Phe Tyr Thr Gly Glu Glu Asn Asp Leu Leu Tyr 
465                 470                 475                 480 


Gln Leu His Asn Lys Gly Trp Tyr Asn Lys Pro Ile Arg Gly Arg Val 
                485                 490                 495     


Thr Phe Asp Gly Gln Val Thr Leu His Glu His Ser Arg Thr Tyr Asp 
            500                 505                 510         


Ser Leu Ser Asn Gln Arg Ala Cys Asn Pro Arg Leu Gly Cys Pro Ser 
        515                 520                 525             


Thr Cys Glu Leu Thr Ser Met Ala Ser Tyr Phe Pro Leu Asp Lys Asp 
    530                 535                 540                 


Phe Lys Ala Ala Val Gly Val Ile Ala Leu Arg Asn Gly Met Thr Pro 
545                 550                 555                 560 


Ile Ile Thr Tyr Ser Thr Asp Asp Trp Arg Asn His Trp Lys Tyr Ile 
                565                 570                 575     


Lys Asn Ala Asp Leu Glu Phe Ser Glu Ser Ser Leu Ser Cys Tyr Ser 
            580                 585                 590         


Pro Asn Pro Pro Leu Asp Asp Tyr Val Leu Cys Thr Ala Val Ile Thr 
        595                 600                 605             


Ala Lys Val Met Ser Asn Thr Asn Pro Gln Leu Leu Ala Thr Ser Trp 
    610                 615                 620                 


Tyr Gln Tyr Asp Lys Cys His Thr 
625                 630         


<210>  390
<211>  557
<212>  PRT
<213>  Myodes narmovirus

<400>  390

Met Tyr Lys Val Val Leu Leu Phe Leu Leu Leu Cys Asn Ala Pro Val 
1               5                   10                  15      


Val Ala Gln Leu Ala Thr Ser Gln Leu Gly Ser Ile Gly Val Tyr Ser 
            20                  25                  30          


Val Lys Glu Leu Glu Tyr Arg Val Thr Gly Glu Tyr Val Thr Gln Tyr 
        35                  40                  45              


Leu Val Val Gln Ile Ile Pro Glu Leu Pro Thr Asn Asp Asn Cys Thr 
    50                  55                  60                  


Arg Pro Val Val Arg Asp Tyr Lys Asp Ser Ile Tyr Asn Ile Leu Ala 
65                  70                  75                  80  


Pro Val Asn Glu Thr Leu Asp Ile Val Ser Thr Tyr Val Gly Pro Tyr 
                85                  90                  95      


Ser Gly Thr Lys Arg Phe Val Ala Glu Ile Ile Ala Gly Ala Ala Leu 
            100                 105                 110         


Gly Val Ala Thr Ala Ala Gln Ile Thr Ala Gly Ile Ala Leu Tyr Glu 
        115                 120                 125             


Ala Arg Gln Asn Ala Ala Gln Ile Glu Ala Ile Lys Ser Ser Leu Lys 
    130                 135                 140                 


His Thr Asn Ala Ala Ile Gln Ser Leu Gln Thr Ala Gln Lys Gln Thr 
145                 150                 155                 160 


Val Val Ala Ile Arg Ser Ile Gln Asp Gln Ile Asn Thr Lys Ile Ile 
                165                 170                 175     


Pro Gln Leu Asn Thr Leu Ser Cys Asp Leu Ile Gly Gln Gln Leu Arg 
            180                 185                 190         


Leu Ser Leu Leu Glu Tyr Tyr Thr Glu Ile Leu Thr Val Phe Gly Pro 
        195                 200                 205             


Ile Ile Gln Ser Pro Leu Asn Gly Glu Val Thr Ile Gln Ala Ile Ala 
    210                 215                 220                 


Arg Ser Ala Gly Gly Asn Leu Thr Gly Leu Leu Asn Glu Leu Gly Tyr 
225                 230                 235                 240 


Asn Ser Gln Asp Leu Lys Asn Ile Leu Glu Ile Asn Ala Ile Arg Gly 
                245                 250                 255     


Ser Val Val Asp Val Asp Pro Ile Leu Gly Thr Leu Ile Phe Asn Ile 
            260                 265                 270         


Arg Tyr Pro Thr Phe Ile Lys Ile Pro Asp Ala Thr Ile Ile Gln Leu 
        275                 280                 285             


Ala Tyr Val Ser Phe His Ser Gly Ser Tyr Asp Trp Met Thr Gln Gly 
    290                 295                 300                 


Pro Ser His Ile Met Val Arg Gly Tyr Thr Ile Ala Asp Val Asp Thr 
305                 310                 315                 320 


Thr Gln Cys Thr Val Gly Ser Asn Tyr Leu Met Cys Pro Arg Asp Thr 
                325                 330                 335     


Thr Lys Pro Phe Ser Ser Ser Met Asn Gln Cys Leu Arg Gly Asn Leu 
            340                 345                 350         


Thr Tyr Cys Pro Arg Thr Ile Val Thr Asp Arg Asp Ala Pro Arg Phe 
        355                 360                 365             


Leu Val Val Lys Gly Asn Leu Val Ala Asn Cys Ile Thr Ile Asn Cys 
    370                 375                 380                 


Lys Cys Glu Asp Pro Glu Tyr Thr Ile Met Gln Ala Lys Asp Glu Pro 
385                 390                 395                 400 


Leu Val Ile Leu Asp Asn Gly Thr Cys Lys Ala His Phe Val Asp Gly 
                405                 410                 415     


Ile Arg Ile Ala Leu Gly Pro Arg Lys Leu Pro Thr Ile Tyr Leu Ser 
            420                 425                 430         


Lys Glu Ile Lys Leu Gly Pro Val Ile Thr Val Asn Pro Val Glu Val 
        435                 440                 445             


Ser His Gln Leu Ser Val Ile Glu Asp Asn Ile Glu Asn Ser Glu Ala 
    450                 455                 460                 


His Leu Lys Ile Ala Ile Glu Lys Leu Asn Asn Val Pro Gln Leu Asn 
465                 470                 475                 480 


Gly Ser Tyr Val Ser Pro Val Val Ala Ile Val Ile Ser Val Val Ser 
                485                 490                 495     


Leu Cys Val Thr Leu Val Val Ala Phe Leu Leu Tyr Arg Tyr Ile Asn 
            500                 505                 510         


His Val Gln Asn Leu Arg Phe Asn Leu Asp Thr Ile Glu Lys Gly Pro 
        515                 520                 525             


Thr Leu Ala Pro Lys Gly His His Tyr Pro Gly Ser Tyr Leu Asn Gln 
    530                 535                 540                 


Gly Phe Ser Ser Tyr Pro Ser Ala Pro Ser Leu Ala Met 
545                 550                 555         


<210>  391
<211>  625
<212>  PRT
<213>  Myodes narmovirus

<400>  391

Met Asp Gln Ala Arg Tyr Tyr Thr Gly Thr Gly Arg Asn Asn Glu Leu 
1               5                   10                  15      


Ala Ser Ala Ser Thr Lys Ile Arg Thr Ile Pro Tyr Ile His Asn Asn 
            20                  25                  30          


Thr Val Asn Arg Gly Phe Asn Phe Leu Leu Asp Val Val Ala Val Ile 
        35                  40                  45              


Gly Val Val Leu Gly Val Ile Ser Ile Gly Leu Ser Thr Thr Ser Ile 
    50                  55                  60                  


Ile Tyr His Thr Arg Thr Gln Asn Val Thr Thr Lys Ala Asp Pro Tyr 
65                  70                  75                  80  


Ile Lys Pro Ile Tyr Asp Asp Val Lys Gln Ile Ser Gln Tyr Tyr Thr 
                85                  90                  95      


Glu Tyr Ile Asp Pro Arg Leu Arg Asn Ile Leu Asp Ala Val Thr Phe 
            100                 105                 110         


Gln Ile Pro Lys Thr Leu Ala Ser Ile Thr Ser Thr Leu Gly Ala Ser 
        115                 120                 125             


Glu Leu Gln Glu Gln Gln Glu Ala Phe Asn Ala Leu Leu Asp Gly Ile 
    130                 135                 140                 


Thr Thr Thr Leu Arg Ser Ala Val Asn Ser Leu Asn Gln Leu Thr Ser 
145                 150                 155                 160 


Ile Ile Leu Glu Gln Phe Asp Glu Thr Lys Leu Ile Val Arg Glu Ile 
                165                 170                 175     


Asn Asn Glu Ile Leu Asn Thr Asn Lys Ser Phe Ile Pro Ile Glu His 
            180                 185                 190         


Pro Phe Thr Gln Tyr Pro Arg Val His Thr Thr Ser Met Ser Ser Leu 
        195                 200                 205             


Pro Pro Leu Arg Cys Thr Arg Ala Val Pro Thr Ala Asn Pro Lys Arg 
    210                 215                 220                 


Val Pro Ile Phe Val Ser Asn Val Gly Gly Met Leu Glu Asn Ser Cys 
225                 230                 235                 240 


Thr Lys Glu Pro Val Ile Ser Met Ala Asn Gly Val Phe Ala Ser Thr 
                245                 250                 255     


Tyr Leu Tyr Leu Arg Asp Ser Cys Thr Asp Tyr Gln Ser Ser Ile Arg 
            260                 265                 270         


Phe Phe Glu Met Gly Ile Val Lys Arg Leu Ser Asp Asn Asp Pro Tyr 
        275                 280                 285             


Leu Ser Val Ile His Thr Trp Asp Gln Ala Ser Pro Phe Val Leu Gln 
    290                 295                 300                 


Pro Cys Ser Leu Ala Val Ala Tyr Asp Asn Gly Tyr Ala Leu Cys Ala 
305                 310                 315                 320 


Glu Ser Val Thr Gly Val Asp Asn Asp Leu Val Thr Gly Asn Thr Ile 
                325                 330                 335     


Arg Leu Val Leu Phe Thr Phe Thr Leu Phe Gly Ser Leu Glu Arg Lys 
            340                 345                 350         


Val Ile Tyr Tyr Glu Asn Phe Lys Arg Pro Arg Glu Phe Val Tyr Ile 
        355                 360                 365             


Ile Pro Gly Ala Gly Gln Gly Val Ile Ile Asp Asn Val Met Tyr Ser 
    370                 375                 380                 


Ile Gly Tyr Tyr Val Ser Glu Asn Thr Pro Gln Gly Asn Leu Lys Cys 
385                 390                 395                 400 


Pro Thr Thr Gly Cys Pro Asn Leu Gln Tyr Ser Thr Cys Asp Gln Phe 
                405                 410                 415     


Ser Arg Thr Gln Val Ser Asn His Arg His Lys Phe Leu Thr Leu Ile 
            420                 425                 430         


Gln Val Asn Leu Thr Gln Tyr Pro Leu Pro Val His Asn Leu Leu Val 
        435                 440                 445             


Ile Pro Arg Ser Tyr Tyr Ser Ile Ile Ser His Gly Asn Leu Tyr Tyr 
    450                 455                 460                 


Arg Asn Ser Asn Asp Ser Val Leu Phe Gln Leu Tyr Asn Val Gly Trp 
465                 470                 475                 480 


Tyr His Lys Pro Leu Val Gly Ser Ile Asn Leu Thr Thr Pro Leu Ser 
                485                 490                 495     


Leu Glu Phe Leu Asn Lys Asp Tyr Asp Leu Leu Ser Ser Val Thr Asn 
            500                 505                 510         


Cys Val Pro Gly Phe Gly Cys Pro Ser Ser Cys Glu Ile Ser Ala Tyr 
        515                 520                 525             


Gly Ala Tyr Thr Pro Leu Asp Tyr Asn Phe Asn Asp Ala Val Ser Leu 
    530                 535                 540                 


Ile Pro Arg Thr Ser Gly Ala Tyr Pro Ser Val Ser Tyr Gly Ser Gly 
545                 550                 555                 560 


Asn Thr Arg Ile Asp Phe Arg Ile Ile Leu Asn Gln Gln Leu Ala Leu 
                565                 570                 575     


Arg Glu Ser Ser Leu Val Cys Tyr Leu Pro Thr Ile Gln Asn Thr Gly 
            580                 585                 590         


His Pro Tyr Cys Val Gly Leu Met Thr Phe Glu Val Thr Gly Gln Thr 
        595                 600                 605             


Ala Pro Gln Leu Tyr Ser Val Gly Trp Lys Gln Thr Tyr Gln Cys Ser 
    610                 615                 620                 


Lys 
625 


<210>  392
<211>  566
<212>  PRT
<213>  Nariva narmovirus

<400>  392

Met Ala Glu Gln Glu Lys Thr Pro Leu Arg Tyr Lys Ile Leu Leu Ile 
1               5                   10                  15      


Ile Ile Val Ile Asn His Tyr Asn Ile Thr Asn Val Phe Gly Gln Ile 
            20                  25                  30          


His Leu Ala Asn Leu Ser Ser Ile Gly Val Phe Val Thr Lys Thr Leu 
        35                  40                  45              


Asp Tyr Arg Thr Thr Ser Asp Pro Thr Glu Gln Leu Leu Val Ile Asn 
    50                  55                  60                  


Met Leu Pro Asn Ile Ser Asn Ile Gln Asp Cys Ala Gln Gly Val Val 
65                  70                  75                  80  


Asn Glu Tyr Lys His Leu Ile Ser Ser Leu Leu Thr Pro Ile Asn Asp 
                85                  90                  95      


Thr Leu Asp Leu Ile Thr Ser Asn Ile Asn Pro Tyr Ser Gly Arg Asn 
            100                 105                 110         


Lys Leu Phe Gly Glu Ile Ile Ala Gly Ala Ala Leu Thr Val Ala Thr 
        115                 120                 125             


Ser Ala Gln Ile Thr Ala Gly Val Ala Leu Tyr Glu Ala Arg Gln Asn 
    130                 135                 140                 


Ala Lys Asp Ile Ala Ala Ile Lys Glu Ser Leu Gly Tyr Ala Tyr Lys 
145                 150                 155                 160 


Ala Ile Asp Lys Leu Thr Thr Ala Thr Arg Glu Ile Thr Val Val Ile 
                165                 170                 175     


Asn Glu Leu Gln Asp Gln Ile Asn Asn Arg Leu Ile Pro Arg Ile Asn 
            180                 185                 190         


Asp Leu Ala Cys Glu Val Trp Ala Thr Arg Leu Gln Ala Met Leu Leu 
        195                 200                 205             


Gln Tyr Tyr Ala Glu Ile Phe Ser Val Ile Gly Pro Asn Leu Gln Asp 
    210                 215                 220                 


Pro Leu Ser Gly Lys Ile Ser Ile Gln Ala Leu Ala Arg Ala Ala Gly 
225                 230                 235                 240 


Gly Asn Ile Lys Leu Met Val Asp Glu Leu Asn Tyr Ser Gly Gln Asp 
                245                 250                 255     


Leu Ser Arg Leu Val Lys Val Gly Ala Ile Lys Gly Gln Ile Ile Asp 
            260                 265                 270         


Ala Asp Pro Ser Leu Gly Val Val Ile Ile Lys Met Arg Tyr Pro Asn 
        275                 280                 285             


Ile Ile Lys Ile Pro Asn Val Ala Ile Ser Glu Leu Ser Tyr Val Ser 
    290                 295                 300                 


Tyr Ser Ser Asp Gly Gln Asp Trp Ile Thr Thr Gly Pro Asn Tyr Ile 
305                 310                 315                 320 


Val Thr Arg Gly Tyr Ser Ile Ala Asn Ile Gln Thr Ser Ser Cys Ser 
                325                 330                 335     


Val Gly Asp Asp Phe Val Leu Cys Asp Arg Asp Met Thr Tyr Pro Met 
            340                 345                 350         


Ser Gln Val Thr Gln Asp Cys Leu Arg Gly Asn Ile Ala Leu Cys Ser 
        355                 360                 365             


Arg Met Val Val Arg Asp Arg Glu Ala Pro Arg Tyr Leu Ile Leu Gln 
    370                 375                 380                 


Gly Asn Met Val Ala Asn Cys Met Ser Ile Thr Cys Arg Cys Glu Glu 
385                 390                 395                 400 


Pro Glu Ser Glu Ile Tyr Gln Ser Pro Asp Gln Pro Leu Thr Leu Leu 
                405                 410                 415     


Thr Arg Asp Thr Cys Asp Thr His Val Val Asp Gly Ile Arg Ile Arg 
            420                 425                 430         


Leu Gly Val Arg Lys Leu Pro Thr Ile Ser Val Ile Asn Asn Ile Thr 
        435                 440                 445             


Leu Gly Pro Ile Ile Thr Thr Asp Pro Ile Asp Val Ser Asn Gln Leu 
    450                 455                 460                 


Asn Ala Val Val Ser Thr Ile Asp Gln Ser Ala Glu Leu Leu His Gln 
465                 470                 475                 480 


Ala Gln Arg Val Leu Ser Glu Arg Ala Arg Gly Ala Arg Asp His Ile 
                485                 490                 495     


Leu Ala Thr Ala Ala Ile Val Ile Cys Val Val Leu Ala Val Leu Ile 
            500                 505                 510         


Leu Val Leu Leu Ile Gly Leu Val Tyr Leu Tyr Arg Thr Gln Asn Glu 
        515                 520                 525             


Ile Leu Val Lys Thr Thr Met Leu Glu Gln Val Pro Thr Phe Ala Pro 
    530                 535                 540                 


Lys Ser Phe Pro Met Glu Ser Gln Ile Tyr Ser Gly Lys Thr Asn Lys 
545                 550                 555                 560 


Gly Tyr Asp Pro Ala Glu 
                565     


<210>  393
<211>  657
<212>  PRT
<213>  Nariva narmovirus

<400>  393

Met Ala Pro Ile Asn Tyr Pro Ala Ser Tyr Tyr Thr Asn Asn Ala Glu 
1               5                   10                  15      


Arg Pro Val Val Ile Thr Thr Lys Ser Thr Glu Ser Lys Gly Gln Arg 
            20                  25                  30          


Pro Leu Pro Leu Gly Asn Ala Arg Phe Trp Glu Tyr Phe Gly His Val 
        35                  40                  45              


Cys Gly Thr Leu Thr Phe Cys Met Ser Leu Ile Gly Ile Ile Val Gly 
    50                  55                  60                  


Ile Ile Ala Leu Ala Asn Tyr Ser Ser Asp Lys Asp Trp Lys Gly Arg 
65                  70                  75                  80  


Ile Gly Gly Asp Ile Gln Val Thr Arg Met Ala Thr Glu Lys Thr Val 
                85                  90                  95      


Lys Leu Ile Leu Glu Asp Thr Thr Pro Lys Leu Arg Asn Ile Leu Asp 
            100                 105                 110         


Ser Val Leu Phe Gln Leu Pro Lys Met Leu Ala Ser Ile Ala Ser Lys 
        115                 120                 125             


Ile Asn Thr Gln Thr Pro Pro Pro Pro Thr Thr Ser Gly His Ser Thr 
    130                 135                 140                 


Ala Leu Ala Thr Gln Cys Ser Ser Asn Cys Glu Asn Arg Pro Glu Ile 
145                 150                 155                 160 


Gly Tyr Asp Tyr Leu Arg Gln Val Glu Gln Ser Leu Gln Arg Ile Thr 
                165                 170                 175     


Asn Ile Ser Ile Gln Leu Leu Glu Ala Ser Glu Ile His Ser Met Ala 
            180                 185                 190         


Gly Ala Tyr Pro Asn Ala Leu Tyr Lys Ile Arg Thr Gln Asp Ser Trp 
        195                 200                 205             


Ser Val Thr Ala Lys Glu Cys Pro Leu Gln Ala Phe Gln Pro Asn Leu 
    210                 215                 220                 


Asn Leu Ile Pro Ala Met Ile Gly Thr Ala Thr Gly Ala Leu Ile Arg 
225                 230                 235                 240 


Asn Cys Val Arg Gln Pro Val Ile Val Val Asp Asp Gly Val Tyr Met 
                245                 250                 255     


Leu Thr Tyr Leu Ala Met Arg Gly Ser Cys Gln Asp His Gln Lys Ser 
            260                 265                 270         


Val Arg His Phe Glu Met Gly Val Ile Thr Ser Asp Pro Phe Gly Asp 
        275                 280                 285             


Pro Val Pro Thr Pro Leu Arg His Trp Thr Lys Arg Ala Leu Pro Ala 
    290                 295                 300                 


Tyr Asp Gly Cys Ala Leu Ala Val Lys Gly His Ala Gly Phe Ala Leu 
305                 310                 315                 320 


Cys Thr Glu Thr Ser Val Gly Pro Leu Arg Asp Arg Thr Ala Lys Arg 
                325                 330                 335     


Lys Pro Asn Ile Val Leu Phe Lys Ala Ser Leu Val Gly Glu Leu Ser 
            340                 345                 350         


Glu Arg Val Ile Pro Pro Gln Ser Trp Leu Ser Gly Phe Ser Phe Phe 
        355                 360                 365             


Ser Val Tyr Thr Val Ala Gly Lys Gly Tyr Ala Tyr His Ser Lys Phe 
    370                 375                 380                 


His Ala Phe Gly Asn Val Val Arg Val Gly Gln Ser Glu Tyr Gln Ala 
385                 390                 395                 400 


Lys Cys Arg Gly Thr Gly Cys Pro Thr Ala Asn Gln Asp Asp Cys Asn 
                405                 410                 415     


Thr Ala Gln Arg Val Ser Gln Glu Asp Asn Thr Tyr Leu His Gln Ala 
            420                 425                 430         


Ile Leu Ser Val Asp Ile Asp Ser Val Ile Asp Pro Glu Asp Val Val 
        435                 440                 445             


Tyr Val Ile Glu Arg Asp Gln Tyr Tyr Gln Ala Ser Ala Gly Asp Leu 
    450                 455                 460                 


Tyr Arg Val Pro Glu Thr Gly Glu Ile Leu Tyr Asn Leu His Asn Gly 
465                 470                 475                 480 


Gly Trp Ser Asn Glu Val Gln Val Gly Arg Ile Gln Pro Ser Asp Arg 
                485                 490                 495     


Phe Tyr Met Arg Glu Ile Gln Leu Thr Ser Thr Arg Val Pro Ala Pro 
            500                 505                 510         


Asn Gly Cys Asn Arg Val Lys Gly Cys Pro Gly Gly Cys Val Ala Val 
        515                 520                 525             


Ile Ser Pro Ala Phe Thr Pro Met His Pro Glu Phe Asn Val Gly Val 
    530                 535                 540                 


Gly Ile Phe Pro Met Asn Gln Pro His Asn Pro Ser Ile Met His Val 
545                 550                 555                 560 


Gln Gln Gln Thr Glu Leu Phe Trp Lys Pro Ile Val Gly Gly Asn Ile 
                565                 570                 575     


Thr Leu His Glu Ser Ser Ile Ala Cys Tyr Ser Thr Val Pro Pro Asn 
            580                 585                 590         


Pro Ser Tyr Asp Leu Cys Ile Gly Val Met Thr Leu Leu Leu His Gln 
        595                 600                 605             


Gly Gln Leu Pro Gln Phe Gln Ala Leu Ser Trp Tyr Gln Pro Thr Met 
    610                 615                 620                 


Cys Asn Gly Asn Ala Pro Gln Asn Arg Arg Ala Leu Ile Pro Val Ile 
625                 630                 635                 640 


Val Glu Asp Ser Lys Ala Met Ser Val Ser Ser Asp Ala Pro Arg Thr 
                645                 650                 655     


Pro 
    


<210>  394
<211>  553
<212>  PRT
<213>  Tupaia narmovirus

<400>  394

Met Ala Ser Leu Leu Lys Thr Ile Cys Tyr Ile Tyr Leu Ile Thr Tyr 
1               5                   10                  15      


Ala Lys Leu Glu Pro Thr Pro Lys Ser Gln Leu Asp Leu Asp Ser Leu 
            20                  25                  30          


Ala Ser Ile Gly Val Val Asp Ala Gly Lys Tyr Asn Tyr Lys Leu Met 
        35                  40                  45              


Thr Thr Gly Ser Glu Lys Leu Met Val Ile Lys Leu Val Pro Asn Ile 
    50                  55                  60                  


Thr Tyr Ala Thr Asn Cys Asn Leu Thr Ala His Thr Ala Tyr Thr Lys 
65                  70                  75                  80  


Met Ile Glu Arg Leu Leu Thr Pro Ile Asn Gln Ser Leu Tyr Glu Met 
                85                  90                  95      


Arg Ser Val Ile Thr Glu Arg Asp Gly Gly Thr Ile Phe Trp Gly Ala 
            100                 105                 110         


Ile Ile Ala Gly Ala Ala Leu Gly Val Ala Thr Ala Ala Ala Ile Thr 
        115                 120                 125             


Ala Gly Val Ala Leu His Arg Ala Glu Gln Asn Ala Arg Asn Ile Ala 
    130                 135                 140                 


Ala Leu Lys Asp Ala Leu Arg Asn Ser Asn Glu Ala Ile Gln His Leu 
145                 150                 155                 160 


Lys Asp Ala Gln Gly His Thr Val Leu Ala Ile Gln Gly Leu Gln Glu 
                165                 170                 175     


Gln Ile Asn Asn Asn Ile Ile Pro Lys Leu Lys Glu Ser His Cys Leu 
            180                 185                 190         


Gly Val Asn Asn Gln Leu Gly Leu Leu Leu Asn Gln Tyr Tyr Ser Glu 
        195                 200                 205             


Ile Leu Thr Val Phe Gly Pro Asn Leu Gln Asn Pro Val Ser Ala Ser 
    210                 215                 220                 


Leu Thr Ile Gln Ala Ile Ala Lys Ala Phe Asn Gly Asp Phe Asn Ser 
225                 230                 235                 240 


Leu Met Thr Asn Leu Asn Tyr Asp Pro Thr Asp Leu Leu Asp Ile Leu 
                245                 250                 255     


Glu Ser Asn Ser Ile Asn Gly Arg Ile Ile Asp Val Asn Leu Asn Glu 
            260                 265                 270         


Lys Tyr Ile Ala Leu Ser Ile Glu Ile Pro Asn Phe Ile Thr Leu Thr 
        275                 280                 285             


Asp Ala Lys Ile Gln Thr Phe Asn Arg Ile Thr Tyr Gly Tyr Gly Ser 
    290                 295                 300                 


Asn Glu Trp Leu Thr Leu Ile Pro Asp Asn Ile Leu Glu Tyr Gly Asn 
305                 310                 315                 320 


Leu Ile Ser Asn Val Asp Leu Thr Ser Cys Val Lys Thr Lys Ser Ser 
                325                 330                 335     


Tyr Ile Cys Asn Gln Asp Thr Ser Tyr Pro Ile Ser Ser Glu Leu Thr 
            340                 345                 350         


Arg Cys Leu Arg Gly Asp Thr Ser Ser Cys Pro Arg Thr Pro Val Val 
        355                 360                 365             


Asn Ser Arg Ala Pro Thr Phe Ala Leu Ser Gly Gly His Ile Tyr Ala 
    370                 375                 380                 


Asn Cys Ala Lys Ala Ala Cys Arg Cys Glu Lys Pro Pro Met Ala Ile 
385                 390                 395                 400 


Val Gln Pro Ala Thr Ser Thr Leu Thr Phe Leu Thr Glu Lys Glu Cys 
                405                 410                 415     


Gln Glu Val Val Ile Asp Gln Ile Asn Ile Gln Leu Ala Pro Asn Arg 
            420                 425                 430         


Leu Asn Lys Thr Ile Ile Thr Asp Gly Ile Asp Leu Gly Pro Glu Val 
        435                 440                 445             


Ile Ile Asn Pro Ile Asp Val Ser Ala Glu Leu Gly Asn Ile Glu Leu 
    450                 455                 460                 


Glu Met Asp Lys Thr Gln Lys Ala Leu Asp Arg Ser Asn Lys Ile Leu 
465                 470                 475                 480 


Asp Ser Met Ile Thr Glu Val Thr Pro Asp Lys Leu Leu Ile Ala Met 
                485                 490                 495     


Ile Val Val Phe Gly Ile Leu Leu Leu Trp Leu Phe Gly Val Ser Tyr 
            500                 505                 510         


Tyr Ala Phe Lys Ile Trp Ser Lys Leu His Phe Leu Asp Ser Tyr Val 
        515                 520                 525             


Tyr Ser Leu Arg Asn Pro Ser His His Arg Ser Asn Gly His Gln Asn 
    530                 535                 540                 


His Ser Phe Ser Thr Asp Ile Ser Gly 
545                 550             


<210>  395
<211>  665
<212>  PRT
<213>  Tupaia narmovirus

<400>  395

Met Asp Tyr His Ser His Thr Thr Gln Thr Gly Ser Asn Glu Thr Leu 
1               5                   10                  15      


Tyr Gln Asp Pro Leu Gln Ser Gln Ser Gly Ser Arg Asp Thr Leu Asp 
            20                  25                  30          


Gly Pro Pro Ser Thr Leu Gln His Tyr Ser Asn Pro Pro Pro Tyr Ser 
        35                  40                  45              


Glu Glu Asp Gln Gly Ile Asp Gly Pro Gln Arg Ser Gln Pro Leu Ser 
    50                  55                  60                  


Thr Pro His Gln Tyr Asp Arg Tyr Tyr Gly Val Asn Ile Gln His Thr 
65                  70                  75                  80  


Arg Val Tyr Asn His Leu Gly Thr Ile Tyr Lys Gly Leu Lys Leu Ala 
                85                  90                  95      


Phe Gln Ile Leu Gly Trp Val Ser Val Ile Ile Thr Met Ile Ile Thr 
            100                 105                 110         


Val Thr Thr Leu Lys Lys Met Ser Asp Gly Asn Ser Gln Asp Ser Ala 
        115                 120                 125             


Met Leu Lys Ser Leu Asp Glu Asn Phe Asp Ala Ile Gln Glu Val Ala 
    130                 135                 140                 


Asn Leu Leu Asp Asn Glu Val Arg Pro Lys Leu Gly Val Thr Met Thr 
145                 150                 155                 160 


Gln Thr Thr Phe Gln Leu Pro Lys Glu Leu Ser Glu Ile Lys Arg Tyr 
                165                 170                 175     


Leu Leu Arg Leu Glu Arg Asn Cys Pro Val Cys Gly Thr Glu Ala Thr 
            180                 185                 190         


Pro Gln Gly Ser Lys Gly Asn Ala Ser Gly Asp Thr Ala Phe Cys Pro 
        195                 200                 205             


Pro Cys Leu Thr Arg Gln Cys Ser Glu Asp Ser Thr His Asp Gln Gly 
    210                 215                 220                 


Pro Gly Val Glu Gly Thr Ser Arg Asn His Lys Gly Lys Ile Asn Phe 
225                 230                 235                 240 


Pro His Ile Leu Gln Ser Asp Asp Cys Gly Arg Ser Asp Asn Leu Ile 
                245                 250                 255     


Val Tyr Ser Ile Asn Leu Val Pro Gly Leu Ser Phe Ile Gln Leu Pro 
            260                 265                 270         


Ser Gly Thr Lys His Cys Ile Ile Asp Val Ser Tyr Thr Phe Ser Asp 
        275                 280                 285             


Thr Leu Ala Gly Tyr Leu Ile Val Gly Gly Val Asp Gly Cys Gln Leu 
    290                 295                 300                 


His Asn Lys Ala Ile Ile Tyr Leu Ser Leu Gly Tyr Tyr Lys Thr Lys 
305                 310                 315                 320 


Met Ile Tyr Pro Pro Asp Tyr Ile Ala Ile Ala Thr Tyr Thr Tyr Asp 
                325                 330                 335     


Leu Val Pro Asn Leu Arg Asp Cys Ser Ile Ala Val Asn Gln Thr Ser 
            340                 345                 350         


Leu Ala Ala Ile Cys Thr Ser Lys Lys Thr Lys Glu Asn Gln Asp Phe 
        355                 360                 365             


Ser Thr Ser Gly Val His Pro Phe Tyr Ile Phe Thr Leu Asn Thr Asp 
    370                 375                 380                 


Gly Ile Phe Thr Val Thr Val Ile Glu Gln Ser Gln Leu Lys Leu Asp 
385                 390                 395                 400 


Tyr Gln Tyr Ala Ala Leu Tyr Pro Ala Thr Gly Pro Gly Ile Phe Ile 
                405                 410                 415     


Gly Asp His Leu Val Phe Leu Met Trp Gly Gly Leu Met Thr Lys Ala 
            420                 425                 430         


Glu Gly Asp Ala Tyr Cys Gln Ala Ser Gly Cys Asn Asp Ala His Arg 
        435                 440                 445             


Thr Ser Cys Asn Ile Ala Gln Met Pro Ser Ala Tyr Gly His Arg Gln 
    450                 455                 460                 


Leu Val Asn Gly Leu Leu Met Leu Pro Ile Lys Glu Leu Gly Ser His 
465                 470                 475                 480 


Leu Ile Gln Pro Ser Leu Glu Thr Ile Ser Pro Lys Ile Asn Trp Ala 
                485                 490                 495     


Gly Gly His Gly Arg Leu Tyr Tyr Asn Trp Glu Ile Asn Thr Thr Tyr 
            500                 505                 510         


Ile Tyr Ile Glu Gly Lys Thr Trp Arg Ser Arg Pro Asn Leu Gly Ile 
        515                 520                 525             


Ile Ser Trp Ser Lys Pro Leu Ser Ile Arg Trp Ile Asp His Ser Val 
    530                 535                 540                 


Ala Arg Arg Pro Gly Ala Arg Pro Cys Asp Ser Ala Asn Asp Cys Pro 
545                 550                 555                 560 


Glu Asp Cys Leu Val Gly Gly Tyr Tyr Asp Met Phe Pro Met Ser Ser 
                565                 570                 575     


Asp Tyr Lys Thr Ala Ile Thr Ile Ile Pro Thr His His Gln Trp Pro 
            580                 585                 590         


Ser Ser Pro Ala Leu Lys Leu Phe Asn Thr Asn Arg Glu Val Arg Val 
        595                 600                 605             


Val Met Ile Leu Arg Pro Pro Asn Asn Val Lys Lys Thr Thr Ile Ser 
    610                 615                 620                 


Cys Ile Arg Ile Met Gln Thr Asn Trp Cys Leu Gly Phe Ile Ile Phe 
625                 630                 635                 640 


Lys Glu Gly Asn Asn Ala Trp Gly Gln Ile Tyr Ser Tyr Ile Tyr Gln 
                645                 650                 655     


Val Glu Ser Thr Cys Pro Asn Thr Lys 
            660                 665 


<210>  396
<211>  572
<212>  PRT
<213>  Bovine respirovirus 3

<400>  396

Met Glu Tyr Trp Lys His Thr Asn Ser Thr Lys Asp Thr Asn Asn Glu 
1               5                   10                  15      


Leu Gly Thr Thr Arg Asp Arg His Ser Ser Lys Ala Thr Asn Ile Ile 
            20                  25                  30          


Met Tyr Ile Phe Trp Thr Thr Thr Ser Thr Ile Leu Ser Val Ile Phe 
        35                  40                  45              


Ile Met Ile Leu Ile Asn Leu Ile Gln Glu Asn Asn His Asn Lys Leu 
    50                  55                  60                  


Met Leu Gln Glu Ile Arg Lys Glu Phe Ala Ala Ile Asp Thr Lys Ile 
65                  70                  75                  80  


Gln Lys Thr Ser Asp Asp Ile Gly Thr Ser Ile Gln Ser Gly Ile Asn 
                85                  90                  95      


Thr Arg Leu Leu Thr Ile Gln Ser His Val Gln Asn Tyr Ile Pro Leu 
            100                 105                 110         


Ser Leu Thr Gln Gln Met Ser Asp Leu Arg Lys Phe Ile Asn Asp Leu 
        115                 120                 125             


Thr Thr Lys Arg Glu His Gln Glu Val Pro Ile Gln Arg Met Thr His 
    130                 135                 140                 


Asp Ser Gly Ile Glu Pro Leu Asn Pro Asp Lys Phe Trp Arg Cys Thr 
145                 150                 155                 160 


Ser Gly Asn Pro Ser Leu Thr Ser Ser Pro Lys Ile Arg Leu Ile Pro 
                165                 170                 175     


Gly Pro Gly Leu Leu Ala Thr Ser Thr Thr Val Asn Gly Cys Ile Arg 
            180                 185                 190         


Leu Pro Ser Leu Ala Ile Asn Asn Leu Ile Tyr Ala Tyr Thr Ser Asn 
        195                 200                 205             


Leu Ile Thr Gln Gly Cys Gln Asp Ile Gly Lys Ser Tyr Gln Val Leu 
    210                 215                 220                 


Gln Ile Gly Ile Ile Thr Ile Asn Ser Asp Leu Val Pro Asp Leu Asn 
225                 230                 235                 240 


Pro Arg Val Thr His Thr Phe Asn Ile Asp Asp Asn Arg Lys Ser Cys 
                245                 250                 255     


Ser Leu Ala Leu Leu Asn Thr Asp Val Tyr Gln Leu Cys Ser Thr Pro 
            260                 265                 270         


Lys Val Asp Glu Arg Ser Asp Tyr Ala Ser Thr Gly Ile Glu Asp Ile 
        275                 280                 285             


Val Leu Asp Ile Val Thr Ser Asn Gly Leu Ile Ile Thr Thr Arg Phe 
    290                 295                 300                 


Thr Asn Asn Asn Ile Thr Phe Asp Lys Pro Tyr Ala Ala Leu Tyr Pro 
305                 310                 315                 320 


Ser Val Gly Pro Gly Ile Tyr Tyr Lys Asp Lys Val Ile Phe Leu Gly 
                325                 330                 335     


Tyr Gly Gly Leu Glu His Glu Glu Asn Gly Asp Val Ile Cys Asn Thr 
            340                 345                 350         


Thr Gly Cys Pro Gly Lys Thr Gln Arg Asp Cys Asn Gln Ala Ser Tyr 
        355                 360                 365             


Ser Pro Trp Phe Ser Asn Arg Arg Met Val Asn Ser Ile Ile Val Val 
    370                 375                 380                 


Asp Lys Gly Ile Asp Thr Thr Phe Ser Leu Arg Val Trp Thr Ile Pro 
385                 390                 395                 400 


Met Arg Gln Asn Tyr Trp Gly Ser Glu Gly Arg Leu Leu Leu Leu Gly 
                405                 410                 415     


Asp Arg Ile Tyr Ile Tyr Thr Arg Ser Thr Ser Trp His Ser Lys Leu 
            420                 425                 430         


Gln Leu Gly Val Ile Asp Ile Ser Asp Phe Asn Asn Ile Arg Ile Asn 
        435                 440                 445             


Trp Thr Trp His Asn Val Leu Ser Arg Pro Gly Asn Asp Glu Cys Pro 
    450                 455                 460                 


Trp Gly His Ser Cys Pro Asp Gly Cys Ile Thr Gly Val Tyr Thr Asp 
465                 470                 475                 480 


Ala Tyr Pro Leu Asn Pro Ser Gly Ser Ile Val Ser Ser Val Ile Leu 
                485                 490                 495     


Asp Ser Gln Lys Ser Arg Glu Asn Pro Ile Ile Thr Tyr Ser Thr Ala 
            500                 505                 510         


Thr Asn Arg Val Asn Glu Leu Ala Ile Tyr Asn Arg Thr Leu Pro Ala 
        515                 520                 525             


Ala Tyr Thr Thr Thr Asn Cys Ile Thr His Tyr Asp Lys Gly Tyr Cys 
    530                 535                 540                 


Phe His Ile Val Glu Ile Asn His Arg Ser Leu Asn Thr Phe Gln Pro 
545                 550                 555                 560 


Met Leu Phe Lys Thr Glu Val Pro Lys Asn Cys Ser 
                565                 570         


<210>  397
<211>  540
<212>  PRT
<213>  Bovine respirovirus 3

<400>  397

Met Ile Ile Thr Asn Thr Ile Ile Ile Ile Leu Ile Ile Ser Pro Ser 
1               5                   10                  15      


Phe Cys Gln Ile Asp Ile Thr Lys Leu Gln Arg Val Gly Val Leu Val 
            20                  25                  30          


Asn Asn Pro Lys Gly Met Lys Ile Ser Gln Asn Phe Glu Thr Arg Tyr 
        35                  40                  45              


Leu Ile Leu Ser Leu Ile Pro Lys Ile Glu Asn Ser His Ser Cys Gly 
    50                  55                  60                  


Asp Gln Gln Ile Asn Gln Tyr Lys Lys Leu Leu Asp Arg Leu Ile Ile 
65                  70                  75                  80  


Pro Leu Tyr Asp Gly Leu Lys Leu Gln Lys Asp Val Ile Val Val Ser 
                85                  90                  95      


His Glu Thr Asn Asn Asn Thr Asn Ser Arg Thr Lys Arg Phe Phe Gly 
            100                 105                 110         


Glu Ile Ile Gly Thr Ile Ala Ile Gly Ile Ala Thr Ser Ala Gln Ile 
        115                 120                 125             


Thr Ala Ala Val Ala Leu Val Glu Ala Lys Gln Ala Lys Ser Asp Ile 
    130                 135                 140                 


Glu Lys Leu Lys Glu Ala Ile Arg Asp Thr Asn Lys Ala Val Gln Ser 
145                 150                 155                 160 


Ile Gln Ser Ser Val Gly Asn Leu Ile Val Ala Val Lys Ser Val Gln 
                165                 170                 175     


Asp Tyr Val Asn Asn Glu Ile Val Pro Ser Ile Thr Arg Leu Gly Cys 
            180                 185                 190         


Glu Ala Ala Gly Leu Lys Leu Gly Ile Ala Leu Thr Gln His Tyr Ser 
        195                 200                 205             


Glu Leu Thr Asn Ile Phe Gly Asp Asn Ile Gly Thr Leu Lys Glu Lys 
    210                 215                 220                 


Gly Ile Lys Leu Gln Gly Ile Ala Ser Leu Tyr His Thr Asn Ile Thr 
225                 230                 235                 240 


Glu Ile Phe Thr Thr Ser Thr Val Asp Gln Tyr Asp Ile Tyr Asp Leu 
                245                 250                 255     


Leu Phe Thr Glu Ser Ile Lys Met Arg Val Ile Asp Val Asp Leu Ser 
            260                 265                 270         


Asp Tyr Ser Ile Thr Leu Gln Val Arg Leu Pro Leu Leu Thr Lys Ile 
        275                 280                 285             


Ser Asn Thr Gln Ile Tyr Lys Val Asp Ser Ile Ser Tyr Asn Ile Gln 
    290                 295                 300                 


Gly Lys Glu Trp Tyr Ile Pro Leu Pro Asn His Ile Met Thr Lys Gly 
305                 310                 315                 320 


Ala Phe Leu Gly Gly Ala Asp Ile Lys Glu Cys Ile Glu Ala Phe Ser 
                325                 330                 335     


Ser Tyr Ile Cys Pro Ser Asp Pro Gly Phe Thr Leu Asn His Glu Ile 
            340                 345                 350         


Glu Asn Cys Leu Ser Gly Asn Ile Thr Gln Cys Pro Lys Thr Ile Val 
        355                 360                 365             


Thr Ser Asp Val Val Pro Arg Tyr Ala Phe Val Asn Gly Gly Leu Ile 
    370                 375                 380                 


Ala Asn Cys Ile Thr Thr Thr Cys Thr Cys Asn Gly Val Asp Asn Arg 
385                 390                 395                 400 


Ile Asn Gln Ser Pro Asp Gln Gly Ile Lys Ile Ile Thr His Lys Glu 
                405                 410                 415     


Cys Gln Val Ile Gly Ile Asn Gly Met Leu Phe Ser Thr Asn Arg Glu 
            420                 425                 430         


Gly Thr Leu Ala Thr Tyr Thr Phe Asp Asp Ile Ile Leu Asn Asn Ser 
        435                 440                 445             


Val Ala Leu Asn Pro Ile Asp Ile Ser Met Glu Leu Asn Lys Ala Lys 
    450                 455                 460                 


Leu Glu Leu Glu Glu Ser Lys Glu Trp Ile Lys Lys Ser Asn Gln Lys 
465                 470                 475                 480 


Leu Asp Ser Val Gly Ser Trp Tyr Gln Ser Ser Ala Thr Ile Thr Ile 
                485                 490                 495     


Ile Ile Val Met Ile Val Val Leu Phe Ile Ile Asn Ile Thr Ile Ile 
            500                 505                 510         


Val Val Ile Ile Arg His His Arg Ile Gln Gly Lys Asn Gln Asn Asp 
        515                 520                 525             


Lys Asn Ser Glu Pro Tyr Val Leu Thr Ser Arg Gln 
    530                 535                 540 


<210>  398
<211>  541
<212>  PRT
<213>  Caprine respirovirus 3

<400>  398

Met Ile Lys Lys Ile Ile Cys Ile Phe Ser Met Pro Ile Leu Leu Ser 
1               5                   10                  15      


Phe Cys Gln Val Asp Ile Ile Lys Leu Gln Arg Val Gly Ile Leu Val 
            20                  25                  30          


Ser Lys Pro Lys Ser Ile Lys Ile Ser Gln Asn Phe Glu Thr Arg Tyr 
        35                  40                  45              


Leu Val Leu Asn Leu Ile Pro Asn Ile Glu Asn Ala Gln Ser Cys Gly 
    50                  55                  60                  


Asp Gln Gln Ile Lys Gln Tyr Lys Lys Leu Leu Asp Arg Leu Ile Ile 
65                  70                  75                  80  


Pro Leu Tyr Asp Gly Leu Arg Leu Gln Gln Asp Ile Ile Val Val Asp 
                85                  90                  95      


Asn Asn Leu Lys Asn Asn Thr Asn His Arg Ala Lys Arg Phe Phe Gly 
            100                 105                 110         


Glu Ile Ile Gly Thr Ile Ala Leu Gly Val Ala Thr Ser Ala Gln Ile 
        115                 120                 125             


Thr Ala Ala Val Ala Leu Val Glu Ala Lys Gln Ala Arg Ser Asp Ile 
    130                 135                 140                 


Glu Arg Val Lys Asn Ala Val Arg Asp Thr Asn Lys Ala Val Gln Ser 
145                 150                 155                 160 


Ile Gln Gly Ser Val Gly Asn Leu Ile Val Ala Val Lys Ser Val Gln 
                165                 170                 175     


Asp Tyr Val Asn Asn Glu Ile Val Pro Ser Ile Lys Arg Leu Gly Cys 
            180                 185                 190         


Glu Ala Ala Gly Leu Gln Leu Gly Ile Ala Leu Thr Gln His Tyr Ser 
        195                 200                 205             


Glu Leu Thr Asn Ile Phe Gly Asp Asn Ile Gly Thr Leu Lys Glu Lys 
    210                 215                 220                 


Gly Ile Lys Leu Gln Gly Ile Ala Ser Leu Tyr His Thr Asn Ile Thr 
225                 230                 235                 240 


Glu Ile Phe Thr Thr Ser Thr Val Asp Gln Tyr Asp Ile Tyr Asp Leu 
                245                 250                 255     


Leu Phe Thr Glu Ser Ile Lys Met Arg Val Ile Asp Val Asp Leu Asn 
            260                 265                 270         


Asp Tyr Ser Ile Thr Leu Gln Val Arg Leu Pro Leu Leu Thr Lys Ile 
        275                 280                 285             


Ser Asp Ala Gln Ile Tyr Asn Val Asp Ser Val Ser Tyr Asn Ile Gly 
    290                 295                 300                 


Gly Thr Glu Trp Tyr Ile Pro Leu Pro Arg Asn Ile Met Thr Lys Gly 
305                 310                 315                 320 


Ala Phe Leu Gly Gly Ala Asn Leu Gln Asp Cys Ile Glu Ser Phe Ser 
                325                 330                 335     


Asp Tyr Ile Cys Pro Ser Asp Pro Gly Phe Ile Leu Asn Arg Asp Ile 
            340                 345                 350         


Glu Asn Cys Leu Ser Gly Asn Ile Thr Gln Cys Pro Lys Thr Leu Val 
        355                 360                 365             


Ile Ser Asp Ile Val Pro Arg Tyr Ala Phe Val Asp Gly Gly Val Ile 
    370                 375                 380                 


Ala Asn Cys Leu Ser Thr Thr Cys Thr Cys Asn Gly Ile Asp Asn Arg 
385                 390                 395                 400 


Ile Asn Gln Ala Pro Asp Gln Gly Ile Lys Ile Ile Thr Tyr Lys Asp 
                405                 410                 415     


Cys Gln Thr Ile Gly Ile Asn Gly Met Leu Phe Lys Thr Asn Gln Glu 
            420                 425                 430         


Gly Thr Leu Ala Ala Tyr Thr Pro Val Asp Ile Thr Leu Asn Asn Ser 
        435                 440                 445             


Val Asn Leu Asp Pro Ile Asp Leu Ser Ile Glu Leu Asn Arg Ala Arg 
    450                 455                 460                 


Ser Asp Leu Ala Glu Ser Lys Glu Trp Ile Lys Arg Ser Glu Ala Lys 
465                 470                 475                 480 


Leu Asp Ser Val Gly Ser Trp Tyr Gln Ser Ser Thr Thr Glu Ile Ile 
                485                 490                 495     


Gln Ile Val Met Ile Ile Val Leu Phe Ile Ile Asn Ile Ile Val Leu 
            500                 505                 510         


Ile Val Leu Ile Lys Tyr Ser Arg Ser Gln Asn Gln Ser Met Asn Asn 
        515                 520                 525             


His Met Asn Glu Pro Tyr Ile Leu Thr Asn Lys Val Gln 
    530                 535                 540     


<210>  399
<211>  574
<212>  PRT
<213>  Caprine respirovirus 3

<400>  399

Met Glu Tyr Trp Gly His Thr Asn Asn Pro Asp Lys Ile Asn Arg Lys 
1               5                   10                  15      


Val Gly Val Asp Gln Val Arg Asp Arg Ser Lys Thr Leu Lys Ile Ile 
            20                  25                  30          


Thr Phe Ile Ile Ser Met Met Thr Ser Ile Met Ser Thr Val Ala Leu 
        35                  40                  45              


Ile Leu Ile Leu Ile Met Phe Ile Gln Asn Asn Asn Asn Asn Arg Ile 
    50                  55                  60                  


Ile Leu Gln Glu Leu Arg Asp Glu Thr Asp Ala Ile Glu Ala Arg Ile 
65                  70                  75                  80  


Gln Lys Ala Ser Asn Asp Ile Gly Val Ser Ile Gln Ser Gly Ile Asn 
                85                  90                  95      


Thr Arg Leu Leu Thr Ile Gln Asn His Val Gln Asn Tyr Ile Pro Leu 
            100                 105                 110         


Ala Leu Thr Gln Gln Val Ser Ser Leu Arg Glu Ser Ile Asn Asp Val 
        115                 120                 125             


Ile Thr Lys Arg Glu Glu Thr Gln Ser Lys Met Pro Ile Gln Arg Met 
    130                 135                 140                 


Thr His Asp Asp Gly Ile Glu Pro Leu Ile Pro Asp Asn Phe Trp Lys 
145                 150                 155                 160 


Cys Pro Ser Gly Ile Pro Thr Ile Ser Ala Ser Pro Lys Ile Arg Leu 
                165                 170                 175     


Ile Pro Gly Pro Gly Leu Leu Ala Thr Ser Thr Thr Ile Asn Gly Cys 
            180                 185                 190         


Ile Arg Leu Pro Ser Leu Val Ile Asn Asn Leu Ile Tyr Ala Tyr Thr 
        195                 200                 205             


Ser Asn Leu Ile Thr Gln Gly Cys Gln Asp Ile Gly Lys Ser Tyr Gln 
    210                 215                 220                 


Val Leu Gln Ile Gly Ile Ile Thr Ile Asn Ser Asp Leu Val Pro Asp 
225                 230                 235                 240 


Leu Asn Pro Arg Ile Thr His Thr Phe Asp Ile Asp Asp Asn Arg Lys 
                245                 250                 255     


Ser Cys Ser Leu Ala Leu Arg Asn Ala Asp Val Tyr Gln Leu Cys Ser 
            260                 265                 270         


Thr Pro Lys Val Asp Glu Arg Ser Asp Tyr Ser Ser Ile Gly Ile Glu 
        275                 280                 285             


Asp Ile Val Leu Asp Ile Val Thr Ser Glu Gly Thr Val Ser Thr Thr 
    290                 295                 300                 


Arg Phe Thr Asn Asn Asn Ile Thr Phe Asp Lys Pro Tyr Ala Ala Leu 
305                 310                 315                 320 


Tyr Pro Ser Val Gly Pro Gly Ile Tyr Tyr Asp Asn Lys Ile Ile Phe 
                325                 330                 335     


Leu Gly Tyr Gly Gly Leu Glu His Glu Glu Asn Gly Asp Val Ile Cys 
            340                 345                 350         


Asn Ile Thr Gly Cys Pro Gly Lys Thr Gln His Asp Cys Asn Gln Ala 
        355                 360                 365             


Ser Tyr Ser Pro Trp Phe Ser Asn Arg Arg Met Val Asn Ala Ile Ile 
    370                 375                 380                 


Leu Val Asn Lys Gly Leu Asn Lys Val Pro Ser Leu Gln Val Trp Thr 
385                 390                 395                 400 


Ile Pro Met Arg Gln Asn Tyr Trp Gly Ser Glu Gly Arg Leu Leu Leu 
                405                 410                 415     


Leu Gly Asn Lys Ile Tyr Ile Tyr Thr Arg Ser Thr Ser Trp His Ser 
            420                 425                 430         


Lys Leu Gln Leu Gly Thr Leu Asp Ile Ser Asn Tyr Asn Asp Ile Arg 
        435                 440                 445             


Ile Arg Trp Thr His His Asp Val Leu Ser Arg Pro Gly Ser Glu Glu 
    450                 455                 460                 


Cys Pro Trp Gly Asn Thr Cys Pro Arg Gly Cys Ile Thr Gly Val Tyr 
465                 470                 475                 480 


Asn Asp Ala Tyr Pro Leu Asn Pro Ser Gly Ser Val Val Ser Ser Val 
                485                 490                 495     


Ile Leu Asp Ser Arg Thr Ser Arg Glu Asn Pro Ile Ile Thr Tyr Ser 
            500                 505                 510         


Thr Asp Thr Ser Arg Val Asn Glu Leu Ala Ile Arg Asn Asn Thr Leu 
        515                 520                 525             


Ser Ala Ala Tyr Thr Thr Thr Asn Cys Val Thr His Tyr Gly Lys Gly 
    530                 535                 540                 


Tyr Cys Phe His Ile Ile Glu Ile Asn His Lys Ser Leu Asn Thr Leu 
545                 550                 555                 560 


Gln Pro Met Leu Phe Lys Thr Glu Ile Pro Lys Ser Cys Asn 
                565                 570                 


<210>  400
<211>  555
<212>  PRT
<213>  Human respirovirus 1

<400>  400

Met Gln Lys Ser Glu Ile Leu Phe Leu Ile Tyr Ser Ser Leu Leu Leu 
1               5                   10                  15      


Ser Ser Ser Leu Cys Gln Ile Pro Val Asp Lys Leu Ser Asn Val Gly 
            20                  25                  30          


Val Ile Ile Asn Glu Gly Lys Leu Leu Lys Ile Ala Gly Ser Tyr Glu 
        35                  40                  45              


Ser Arg Tyr Ile Val Leu Ser Leu Val Pro Ser Ile Asp Leu Glu Asp 
    50                  55                  60                  


Gly Cys Gly Thr Thr Gln Ile Ile Gln Tyr Lys Asn Leu Leu Asn Arg 
65                  70                  75                  80  


Leu Leu Ile Pro Leu Lys Asp Ala Leu Asp Leu Gln Glu Ser Leu Ile 
                85                  90                  95      


Thr Ile Thr Asn Asp Thr Thr Val Thr Asn Asp Asn Pro Gln Ser Arg 
            100                 105                 110         


Phe Phe Gly Ala Val Ile Gly Thr Ile Ala Leu Gly Val Ala Thr Ala 
        115                 120                 125             


Ala Gln Ile Thr Ala Gly Ile Ala Leu Ala Glu Ala Arg Glu Ala Arg 
    130                 135                 140                 


Lys Asp Ile Ala Leu Ile Lys Asp Ser Ile Ile Lys Thr His Asn Ser 
145                 150                 155                 160 


Val Glu Leu Ile Gln Arg Gly Ile Gly Glu Gln Ile Ile Ala Leu Lys 
                165                 170                 175     


Thr Leu Gln Asp Phe Val Asn Asn Glu Ile Arg Pro Ala Ile Gly Glu 
            180                 185                 190         


Leu Arg Cys Glu Thr Thr Ala Leu Lys Leu Gly Ile Lys Leu Thr Gln 
        195                 200                 205             


His Tyr Ser Glu Leu Ala Thr Ala Phe Ser Ser Asn Leu Gly Thr Ile 
    210                 215                 220                 


Gly Glu Lys Ser Leu Thr Leu Gln Ala Leu Ser Ser Leu Tyr Ser Ala 
225                 230                 235                 240 


Asn Ile Thr Glu Ile Leu Ser Thr Ile Lys Lys Asp Lys Ser Asp Ile 
                245                 250                 255     


Tyr Asp Ile Ile Tyr Thr Glu Gln Val Lys Gly Thr Val Ile Asp Val 
            260                 265                 270         


Asp Leu Glu Lys Tyr Met Val Thr Leu Leu Val Lys Ile Pro Ile Leu 
        275                 280                 285             


Ser Glu Ile Pro Gly Val Leu Ile Tyr Arg Ala Ser Ser Ile Ser Tyr 
    290                 295                 300                 


Asn Ile Glu Gly Glu Glu Trp His Val Ala Ile Pro Asn Tyr Ile Ile 
305                 310                 315                 320 


Asn Lys Ala Ser Ser Leu Gly Gly Ala Asp Val Thr Asn Cys Ile Glu 
                325                 330                 335     


Ser Arg Leu Ala Tyr Ile Cys Pro Arg Asp Pro Thr Gln Leu Ile Pro 
            340                 345                 350         


Asp Asn Gln Gln Lys Cys Ile Leu Gly Asp Val Ser Lys Cys Pro Val 
        355                 360                 365             


Thr Lys Val Ile Asn Asn Leu Val Pro Lys Phe Ala Phe Ile Asn Gly 
    370                 375                 380                 


Gly Val Val Ala Asn Cys Ile Ala Ser Thr Cys Thr Cys Gly Thr Asn 
385                 390                 395                 400 


Arg Ile Pro Val Asn Gln Asp Arg Ser Arg Gly Val Thr Phe Leu Thr 
                405                 410                 415     


Tyr Thr Asn Cys Gly Leu Ile Gly Ile Asn Gly Ile Glu Leu Tyr Ala 
            420                 425                 430         


Asn Lys Arg Gly Arg Asp Thr Thr Trp Gly Asn Gln Ile Ile Lys Val 
        435                 440                 445             


Gly Pro Ala Val Ser Ile Arg Pro Val Asp Ile Ser Leu Asn Leu Ala 
    450                 455                 460                 


Ser Ala Thr Asn Phe Leu Glu Glu Ser Lys Ile Glu Leu Met Lys Ala 
465                 470                 475                 480 


Lys Ala Ile Ile Ser Ala Val Gly Gly Trp His Asn Thr Glu Ser Thr 
                485                 490                 495     


Gln Ile Ile Ile Ile Ile Ile Val Cys Ile Leu Ile Ile Ile Ile Cys 
            500                 505                 510         


Gly Ile Leu Tyr Tyr Leu Tyr Arg Val Arg Arg Leu Leu Val Met Ile 
        515                 520                 525             


Asn Ser Thr His Asn Ser Pro Val Asn Thr Tyr Thr Leu Glu Ser Arg 
    530                 535                 540                 


Met Arg Asn Pro Tyr Ile Gly Asn Asn Ser Asn 
545                 550                 555 


<210>  401
<211>  575
<212>  PRT
<213>  Human respirovirus 1

<400>  401

Met Ala Glu Lys Gly Lys Thr Asn Ser Ser Tyr Trp Ser Thr Thr Arg 
1               5                   10                  15      


Asn Asp Asn Ser Thr Val Asn Thr Tyr Ile Asp Thr Pro Ala Gly Lys 
            20                  25                  30          


Thr His Ile Trp Leu Leu Ile Ala Thr Thr Met His Thr Ile Leu Ser 
        35                  40                  45              


Phe Ile Ile Met Ile Leu Cys Ile Asp Leu Ile Ile Lys Gln Asp Thr 
    50                  55                  60                  


Cys Met Lys Thr Asn Ile Met Thr Val Ser Ser Met Asn Glu Ser Ala 
65                  70                  75                  80  


Lys Thr Ile Lys Glu Thr Ile Thr Glu Leu Ile Arg Gln Glu Val Ile 
                85                  90                  95      


Ser Arg Thr Ile Asn Ile Gln Ser Ser Val Gln Ser Gly Ile Pro Ile 
            100                 105                 110         


Leu Leu Asn Lys Gln Ser Arg Asp Leu Thr Gln Leu Ile Glu Lys Ser 
        115                 120                 125             


Cys Asn Arg Gln Glu Leu Ala Gln Ile Cys Glu Asn Thr Ile Ala Ile 
    130                 135                 140                 


His His Ala Asp Gly Ile Ser Pro Leu Asp Pro His Asp Phe Trp Arg 
145                 150                 155                 160 


Cys Pro Val Gly Glu Pro Leu Leu Ser Asn Asn Pro Asn Ile Ser Leu 
                165                 170                 175     


Leu Pro Gly Pro Ser Leu Leu Ser Gly Ser Thr Thr Ile Ser Gly Cys 
            180                 185                 190         


Val Arg Leu Pro Ser Leu Ser Ile Gly Asp Ala Ile Tyr Ala Tyr Ser 
        195                 200                 205             


Ser Asn Leu Ile Thr Gln Gly Cys Ala Asp Ile Gly Lys Ser Tyr Gln 
    210                 215                 220                 


Val Leu Gln Leu Gly Tyr Ile Ser Leu Asn Ser Asp Met Tyr Pro Asp 
225                 230                 235                 240 


Leu Lys Pro Val Ile Ser His Thr Tyr Asp Ile Asn Asp Asn Arg Lys 
                245                 250                 255     


Ser Cys Ser Val Ile Ala Ala Gly Thr Arg Gly Tyr Gln Leu Cys Ser 
            260                 265                 270         


Leu Pro Thr Val Asn Glu Thr Thr Asp Tyr Ser Ser Glu Gly Ile Glu 
        275                 280                 285             


Asp Leu Val Phe Asp Ile Leu Asp Leu Lys Gly Lys Thr Lys Ser His 
    290                 295                 300                 


Arg Tyr Lys Asn Glu Asp Ile Thr Phe Asp His Pro Phe Ser Ala Met 
305                 310                 315                 320 


Tyr Pro Ser Val Gly Ser Gly Ile Lys Ile Glu Asn Thr Leu Ile Phe 
                325                 330                 335     


Leu Gly Tyr Gly Gly Leu Thr Thr Pro Leu Gln Gly Asp Thr Lys Cys 
            340                 345                 350         


Val Thr Asn Arg Cys Ala Asn Val Asn Gln Ser Val Cys Asn Asp Ala 
        355                 360                 365             


Leu Lys Ile Thr Trp Leu Lys Lys Arg Gln Val Val Asn Val Leu Ile 
    370                 375                 380                 


Arg Ile Asn Asn Tyr Leu Ser Asp Arg Pro Lys Ile Val Val Glu Thr 
385                 390                 395                 400 


Ile Pro Ile Thr Gln Asn Tyr Leu Gly Ala Glu Gly Arg Leu Leu Lys 
                405                 410                 415     


Leu Gly Lys Lys Ile Tyr Ile Tyr Thr Arg Ser Ser Gly Trp His Ser 
            420                 425                 430         


His Leu Gln Ile Gly Ser Leu Asp Ile Asn Asn Pro Met Thr Ile Lys 
        435                 440                 445             


Trp Ala Pro His Glu Val Leu Ser Arg Pro Gly Asn Gln Asp Cys Asn 
    450                 455                 460                 


Trp Tyr Asn Arg Cys Pro Arg Glu Cys Ile Ser Gly Val Tyr Thr Asp 
465                 470                 475                 480 


Ala Tyr Pro Leu Ser Pro Asp Ala Val Asn Val Ala Thr Thr Thr Leu 
                485                 490                 495     


Tyr Ala Asn Thr Ser Arg Val Asn Pro Thr Ile Met Tyr Ser Asn Thr 
            500                 505                 510         


Ser Glu Ile Ile Asn Met Leu Arg Leu Lys Asn Val Gln Leu Glu Ala 
        515                 520                 525             


Ala Tyr Thr Thr Thr Ser Cys Ile Thr His Phe Gly Lys Gly Tyr Cys 
    530                 535                 540                 


Phe His Ile Val Glu Ile Asn Gln Thr Ser Leu Asn Thr Leu Gln Pro 
545                 550                 555                 560 


Met Leu Phe Lys Thr Ser Ile Pro Lys Ile Cys Lys Ile Thr Ser 
                565                 570                 575 


<210>  402
<211>  572
<212>  PRT
<213>  Human respirovirus 3

<400>  402

Met Glu Tyr Trp Lys His Thr Asn His Gly Lys Asp Ala Gly Asn Glu 
1               5                   10                  15      


Leu Glu Thr Ser Met Ala Thr His Gly Asn Lys Ile Thr Asn Lys Ile 
            20                  25                  30          


Thr Tyr Ile Leu Trp Thr Ile Ile Leu Val Leu Leu Ser Ile Val Phe 
        35                  40                  45              


Ile Ile Val Leu Ile Asn Ser Ile Lys Ser Glu Lys Ala His Glu Ser 
    50                  55                  60                  


Leu Leu Gln Asp Val Asn Asn Glu Phe Met Glu Val Thr Glu Lys Ile 
65                  70                  75                  80  


Gln Met Ala Ser Asp Asn Ile Asn Asp Leu Ile Gln Ser Gly Val Asn 
                85                  90                  95      


Thr Arg Leu Leu Thr Ile Gln Ser His Val Gln Asn Tyr Ile Pro Ile 
            100                 105                 110         


Ser Leu Thr Gln Gln Met Ser Asp Leu Arg Lys Phe Ile Ser Glu Ile 
        115                 120                 125             


Thr Ile Arg Asn Asp Asn Gln Glu Val Pro Pro Gln Arg Ile Thr His 
    130                 135                 140                 


Asp Val Gly Ile Lys Pro Leu Asn Pro Asp Asp Phe Trp Arg Cys Thr 
145                 150                 155                 160 


Ser Gly Leu Pro Ser Leu Met Lys Thr Pro Lys Ile Arg Leu Met Pro 
                165                 170                 175     


Gly Pro Gly Leu Leu Ala Met Pro Thr Thr Val Asp Gly Cys Val Arg 
            180                 185                 190         


Thr Pro Ser Leu Val Ile Asn Asp Leu Ile Tyr Ala Tyr Thr Ser Asn 
        195                 200                 205             


Leu Ile Thr Arg Gly Cys Gln Asp Ile Gly Lys Ser Tyr Gln Val Leu 
    210                 215                 220                 


Gln Ile Gly Ile Ile Thr Val Asn Ser Asp Leu Val Pro Asp Leu Asn 
225                 230                 235                 240 


Pro Arg Ile Ser His Thr Phe Asn Ile Asn Asp Asn Arg Lys Ser Cys 
                245                 250                 255     


Ser Leu Ala Leu Leu Asn Thr Asp Val Tyr Gln Leu Cys Ser Thr Pro 
            260                 265                 270         


Lys Val Asp Glu Arg Ser Asp Tyr Ala Ser Ser Gly Ile Glu Asp Ile 
        275                 280                 285             


Val Leu Asp Ile Val Asn His Asp Gly Ser Ile Ser Thr Thr Arg Phe 
    290                 295                 300                 


Lys Asn Asn Asn Ile Ser Phe Asp Gln Pro Tyr Ala Ala Leu Tyr Pro 
305                 310                 315                 320 


Ser Val Gly Pro Gly Ile Tyr Tyr Lys Gly Lys Ile Ile Phe Leu Gly 
                325                 330                 335     


Tyr Gly Gly Leu Glu His Pro Ile Asn Glu Asn Ala Ile Cys Asn Thr 
            340                 345                 350         


Thr Gly Cys Pro Gly Lys Thr Gln Arg Asp Cys Asn Gln Ala Ser His 
        355                 360                 365             


Ser Pro Trp Phe Ser Asp Arg Arg Met Val Asn Ser Ile Ile Val Val 
    370                 375                 380                 


Asp Lys Gly Leu Asn Ser Ile Pro Lys Leu Lys Val Trp Thr Ile Ser 
385                 390                 395                 400 


Met Arg Gln Asn Tyr Trp Gly Ser Glu Gly Arg Leu Leu Leu Leu Gly 
                405                 410                 415     


Asn Lys Ile Tyr Ile Tyr Thr Arg Ser Thr Ser Trp His Ser Lys Leu 
            420                 425                 430         


Gln Leu Gly Ile Ile Asp Ile Thr Asp Tyr Ser Asp Ile Arg Ile Lys 
        435                 440                 445             


Trp Thr Trp His Asn Val Leu Ser Arg Pro Gly Asn Asn Glu Cys Pro 
    450                 455                 460                 


Trp Gly His Ser Cys Pro Asp Gly Cys Ile Thr Gly Val Tyr Thr Asp 
465                 470                 475                 480 


Ala Tyr Pro Leu Asn Pro Thr Gly Ser Ile Val Ser Ser Val Ile Leu 
                485                 490                 495     


Asp Ser Gln Lys Ser Arg Val Asn Pro Val Ile Thr Tyr Ser Thr Ser 
            500                 505                 510         


Thr Glu Arg Val Asn Glu Leu Ala Ile Arg Asn Lys Thr Leu Ser Ala 
        515                 520                 525             


Gly Tyr Thr Thr Thr Ser Cys Ile Thr His Tyr Asn Lys Gly Tyr Cys 
    530                 535                 540                 


Phe His Ile Val Glu Ile Asn His Lys Ser Leu Asp Thr Phe Gln Pro 
545                 550                 555                 560 


Met Leu Phe Lys Thr Glu Ile Pro Lys Ser Cys Ser 
                565                 570         


<210>  403
<211>  539
<212>  PRT
<213>  Human respirovirus 3

<400>  403

Met Pro Thr Ser Ile Leu Leu Ile Ile Thr Thr Met Ile Met Ala Ser 
1               5                   10                  15      


Phe Cys Gln Ile Asp Ile Thr Lys Leu Gln His Val Gly Val Leu Val 
            20                  25                  30          


Asn Ser Pro Lys Gly Met Lys Ile Ser Gln Asn Phe Glu Thr Arg Tyr 
        35                  40                  45              


Leu Ile Leu Ser Leu Ile Pro Lys Ile Glu Asp Ser Asn Ser Cys Gly 
    50                  55                  60                  


Asp Gln Gln Ile Lys Gln Tyr Lys Arg Leu Leu Asp Arg Leu Ile Ile 
65                  70                  75                  80  


Pro Leu Tyr Asp Gly Leu Arg Leu Gln Lys Asp Val Ile Val Ser Asn 
                85                  90                  95      


Gln Glu Ser Asn Glu Asn Thr Asp Pro Arg Thr Lys Arg Phe Phe Gly 
            100                 105                 110         


Gly Val Ile Gly Thr Ile Ala Leu Gly Val Ala Thr Ser Ala Gln Ile 
        115                 120                 125             


Thr Ala Ala Val Ala Leu Val Glu Ala Lys Gln Ala Arg Ser Asp Ile 
    130                 135                 140                 


Glu Lys Leu Lys Glu Ala Ile Arg Asp Thr Asn Lys Ala Val Gln Ser 
145                 150                 155                 160 


Val Gln Ser Ser Ile Gly Asn Leu Ile Val Ala Ile Lys Ser Val Gln 
                165                 170                 175     


Asp Tyr Val Asn Lys Glu Ile Val Pro Ser Ile Ala Arg Leu Gly Cys 
            180                 185                 190         


Glu Ala Ala Gly Leu Gln Leu Gly Ile Ala Leu Thr Gln His Tyr Ser 
        195                 200                 205             


Glu Leu Thr Asn Ile Phe Gly Asp Asn Ile Gly Ser Leu Gln Glu Lys 
    210                 215                 220                 


Gly Ile Lys Leu Gln Gly Ile Ala Ser Leu Tyr Arg Thr Asn Ile Thr 
225                 230                 235                 240 


Glu Ile Phe Thr Thr Ser Thr Val Asp Lys Tyr Asp Ile Tyr Asp Leu 
                245                 250                 255     


Leu Phe Thr Glu Ser Ile Lys Val Arg Val Ile Asp Val Asp Leu Asn 
            260                 265                 270         


Asp Tyr Ser Ile Thr Leu Gln Val Arg Leu Pro Leu Leu Thr Arg Leu 
        275                 280                 285             


Leu Asn Thr Gln Ile Tyr Arg Val Asp Ser Ile Ser Tyr Asn Ile Gln 
    290                 295                 300                 


Asn Arg Glu Trp Tyr Ile Pro Leu Pro Ser His Ile Met Thr Lys Gly 
305                 310                 315                 320 


Ala Phe Leu Gly Gly Ala Asp Val Lys Glu Cys Ile Glu Ala Phe Ser 
                325                 330                 335     


Ser Tyr Ile Cys Pro Ser Asp Pro Gly Phe Val Leu Asn His Glu Met 
            340                 345                 350         


Glu Ser Cys Leu Ser Gly Asn Ile Ser Gln Cys Pro Arg Thr Val Val 
        355                 360                 365             


Lys Ser Asp Ile Val Pro Arg Tyr Ala Phe Val Asn Gly Gly Val Val 
    370                 375                 380                 


Ala Asn Cys Ile Thr Thr Thr Cys Thr Cys Asn Gly Ile Gly Asn Arg 
385                 390                 395                 400 


Ile Asn Gln Pro Pro Asp Gln Gly Val Lys Ile Ile Thr His Lys Glu 
                405                 410                 415     


Cys Asn Thr Ile Gly Ile Asn Gly Met Leu Phe Asn Thr Asn Lys Glu 
            420                 425                 430         


Gly Thr Leu Ala Phe Tyr Thr Pro Asn Asp Ile Thr Leu Asn Asn Ser 
        435                 440                 445             


Val Ala Leu Asp Pro Ile Asp Ile Ser Ile Glu Leu Asn Lys Ala Lys 
    450                 455                 460                 


Ser Asp Leu Glu Glu Ser Lys Glu Trp Ile Arg Arg Ser Asn Gln Lys 
465                 470                 475                 480 


Leu Asp Ser Ile Gly Asn Trp His Gln Ser Ser Thr Thr Ile Ile Ile 
                485                 490                 495     


Val Leu Ile Met Ile Ile Ile Leu Phe Ile Ile Asn Val Thr Ile Ile 
            500                 505                 510         


Ile Ile Ala Val Lys Tyr Tyr Arg Ile Gln Lys Arg Asn Arg Val Asp 
        515                 520                 525             


Gln Asn Asp Lys Pro Tyr Val Leu Thr Asn Lys 
    530                 535                 


<210>  404
<211>  565
<212>  PRT
<213>  Murine respirovirus

<400>  404

Met Thr Ala Tyr Ile Gln Arg Ser Gln Cys Ile Ser Thr Ser Leu Leu 
1               5                   10                  15      


Val Val Leu Thr Thr Leu Val Ser Cys Gln Ile Pro Arg Asp Arg Leu 
            20                  25                  30          


Ser Asn Ile Gly Val Ile Val Asp Glu Gly Lys Ser Leu Lys Ile Ala 
        35                  40                  45              


Gly Ser His Glu Ser Arg Tyr Ile Val Leu Ser Leu Val Pro Gly Val 
    50                  55                  60                  


Asp Phe Glu Asn Gly Cys Gly Thr Ala Gln Val Ile Gln Tyr Lys Ser 
65                  70                  75                  80  


Leu Leu Asn Arg Leu Leu Ile Pro Leu Arg Asp Ala Leu Asp Leu Gln 
                85                  90                  95      


Glu Ala Leu Ile Thr Val Thr Asn Asp Thr Thr Gln Asn Ala Gly Ala 
            100                 105                 110         


Pro Gln Ser Arg Phe Phe Gly Ala Val Ile Gly Thr Ile Ala Leu Gly 
        115                 120                 125             


Val Ala Thr Ser Ala Gln Ile Thr Ala Gly Ile Ala Leu Ala Glu Ala 
    130                 135                 140                 


Arg Glu Ala Lys Arg Asp Ile Ala Leu Ile Lys Glu Ser Met Thr Lys 
145                 150                 155                 160 


Thr His Lys Ser Ile Glu Leu Leu Gln Asn Ala Val Gly Glu Gln Ile 
                165                 170                 175     


Leu Ala Leu Lys Thr Leu Gln Asp Phe Val Asn Asp Glu Ile Lys Pro 
            180                 185                 190         


Ala Ile Ser Glu Leu Gly Cys Glu Thr Ala Ala Leu Arg Leu Gly Ile 
        195                 200                 205             


Lys Leu Thr Gln His Tyr Ser Glu Leu Leu Thr Ala Phe Gly Ser Asn 
    210                 215                 220                 


Phe Gly Thr Ile Gly Glu Lys Ser Leu Thr Leu Gln Ala Leu Ser Ser 
225                 230                 235                 240 


Leu Tyr Ser Ala Asn Ile Thr Glu Ile Met Thr Thr Ile Lys Thr Gly 
                245                 250                 255     


Gln Ser Asn Ile Tyr Asp Val Ile Tyr Thr Glu Gln Ile Lys Gly Thr 
            260                 265                 270         


Val Ile Asp Val Asp Leu Glu Arg Tyr Met Val Thr Leu Ser Val Lys 
        275                 280                 285             


Ile Pro Ile Leu Ser Glu Val Pro Gly Val Leu Ile His Lys Ala Ser 
    290                 295                 300                 


Ser Ile Ser Tyr Asn Ile Asp Gly Glu Glu Trp Tyr Val Thr Val Pro 
305                 310                 315                 320 


Ser His Ile Leu Ser Arg Ala Ser Phe Leu Gly Gly Ala Asp Ile Thr 
                325                 330                 335     


Asp Cys Val Glu Ser Arg Leu Thr Tyr Ile Cys Pro Arg Asp Pro Ala 
            340                 345                 350         


Gln Leu Ile Pro Asp Ser Gln Gln Lys Cys Ile Leu Gly Asp Thr Thr 
        355                 360                 365             


Arg Cys Pro Val Thr Lys Val Val Asp Ser Leu Ile Pro Lys Phe Ala 
    370                 375                 380                 


Phe Val Asn Gly Gly Val Val Ala Asn Cys Ile Ala Ser Thr Cys Thr 
385                 390                 395                 400 


Cys Gly Thr Gly Arg Arg Pro Ile Ser Gln Asp Arg Ser Lys Gly Val 
                405                 410                 415     


Val Phe Leu Thr His Asp Asn Cys Gly Leu Ile Gly Val Asn Gly Val 
            420                 425                 430         


Glu Leu Tyr Ala Asn Arg Arg Gly His Asp Ala Thr Trp Gly Val Gln 
        435                 440                 445             


Asn Leu Thr Val Gly Pro Ala Ile Ala Ile Arg Pro Ile Asp Ile Ser 
    450                 455                 460                 


Leu Asn Leu Ala Asp Ala Thr Asn Phe Leu Gln Asp Ser Lys Ala Glu 
465                 470                 475                 480 


Leu Glu Lys Ala Arg Lys Ile Leu Ser Glu Val Gly Arg Trp Tyr Asn 
                485                 490                 495     


Ser Arg Glu Thr Val Ile Thr Ile Ile Val Val Met Val Val Ile Leu 
            500                 505                 510         


Val Val Ile Ile Val Ile Ile Ile Val Leu Tyr Arg Leu Arg Arg Ser 
        515                 520                 525             


Met Leu Met Gly Asn Pro Asp Asp Arg Ile Pro Arg Asp Thr Tyr Thr 
    530                 535                 540                 


Leu Glu Pro Lys Ile Arg His Met Tyr Thr Asn Gly Gly Phe Asp Ala 
545                 550                 555                 560 


Met Ala Glu Lys Arg 
                565 


<210>  405
<211>  575
<212>  PRT
<213>  Murine respirovirus

<400>  405

Met Asp Gly Asp Arg Gly Lys Arg Asp Ser Tyr Trp Ser Thr Ser Pro 
1               5                   10                  15      


Ser Gly Ser Thr Thr Lys Pro Ala Ser Gly Trp Glu Arg Ser Ser Lys 
            20                  25                  30          


Ala Asp Thr Trp Leu Leu Ile Leu Ser Phe Thr Gln Trp Ala Leu Ser 
        35                  40                  45              


Ile Ala Thr Val Ile Ile Cys Ile Ile Ile Ser Ala Arg Gln Gly Tyr 
    50                  55                  60                  


Ser Met Lys Glu Tyr Ser Met Thr Val Glu Ala Leu Asn Met Ser Ser 
65                  70                  75                  80  


Arg Glu Val Lys Glu Ser Leu Thr Ser Leu Ile Arg Gln Glu Val Ile 
                85                  90                  95      


Ala Arg Ala Val Asn Ile Gln Ser Ser Val Gln Thr Gly Ile Pro Val 
            100                 105                 110         


Leu Leu Asn Lys Asn Ser Arg Asp Val Ile Gln Met Ile Asp Lys Ser 
        115                 120                 125             


Cys Ser Arg Gln Glu Leu Thr Gln His Cys Glu Ser Thr Ile Ala Val 
    130                 135                 140                 


His His Ala Asp Gly Ile Ala Pro Leu Glu Pro His Ser Phe Trp Arg 
145                 150                 155                 160 


Cys Pro Val Gly Glu Pro Tyr Leu Ser Ser Asp Pro Glu Ile Ser Leu 
                165                 170                 175     


Leu Pro Gly Pro Ser Leu Leu Ser Gly Ser Thr Thr Ile Ser Gly Cys 
            180                 185                 190         


Val Arg Leu Pro Ser Leu Ser Ile Gly Glu Ala Ile Tyr Ala Tyr Ser 
        195                 200                 205             


Ser Asn Leu Ile Thr Gln Gly Cys Ala Asp Ile Gly Lys Ser Tyr Gln 
    210                 215                 220                 


Val Leu Gln Leu Gly Tyr Ile Ser Leu Asn Ser Asp Met Phe Pro Asp 
225                 230                 235                 240 


Leu Asn Pro Val Val Ser His Thr Tyr Asp Ile Asn Asp Asn Arg Lys 
                245                 250                 255     


Ser Cys Ser Val Val Ala Thr Gly Thr Arg Gly Tyr Gln Leu Cys Ser 
            260                 265                 270         


Met Pro Thr Val Asp Glu Arg Thr Asp Tyr Ser Ser Asp Gly Ile Glu 
        275                 280                 285             


Asp Leu Val Leu Asp Val Leu Asp Leu Lys Gly Arg Thr Lys Ser His 
    290                 295                 300                 


Arg Tyr Arg Asn Ser Glu Val Asp Leu Asp His Pro Phe Ser Ala Leu 
305                 310                 315                 320 


Tyr Pro Ser Val Gly Asn Gly Ile Ala Thr Glu Gly Ser Leu Ile Phe 
                325                 330                 335     


Leu Gly Tyr Gly Gly Leu Thr Thr Pro Leu Gln Gly Asp Thr Lys Cys 
            340                 345                 350         


Arg Thr Gln Gly Cys Gln Gln Val Ser Gln Asp Thr Cys Asn Glu Ala 
        355                 360                 365             


Leu Lys Ile Thr Trp Leu Gly Gly Lys Gln Val Val Ser Val Ile Ile 
    370                 375                 380                 


Gln Val Asn Asp Tyr Leu Ser Glu Arg Pro Lys Ile Arg Val Thr Thr 
385                 390                 395                 400 


Ile Pro Ile Thr Gln Asn Tyr Leu Gly Ala Glu Gly Arg Leu Leu Lys 
                405                 410                 415     


Leu Gly Asp Arg Val Tyr Ile Tyr Thr Arg Ser Ser Gly Trp His Ser 
            420                 425                 430         


Gln Leu Gln Ile Gly Val Leu Asp Val Ser His Pro Leu Thr Ile Asn 
        435                 440                 445             


Trp Thr Pro His Glu Ala Leu Ser Arg Pro Gly Asn Lys Glu Cys Asn 
    450                 455                 460                 


Trp Tyr Asn Lys Cys Pro Lys Glu Cys Ile Ser Gly Val Tyr Thr Asp 
465                 470                 475                 480 


Ala Tyr Pro Leu Ser Pro Asp Ala Ala Asn Val Ala Thr Val Thr Leu 
                485                 490                 495     


Tyr Ala Asn Thr Ser Arg Val Asn Pro Thr Ile Met Tyr Ser Asn Thr 
            500                 505                 510         


Thr Asn Ile Ile Asn Met Leu Arg Ile Lys Asp Val Gln Leu Glu Ala 
        515                 520                 525             


Ala Tyr Thr Thr Thr Ser Cys Ile Thr His Phe Gly Lys Gly Tyr Cys 
    530                 535                 540                 


Phe His Ile Ile Glu Ile Asn Gln Lys Ser Leu Asn Thr Leu Gln Pro 
545                 550                 555                 560 


Met Leu Phe Lys Thr Ser Ile Pro Lys Leu Cys Lys Ala Glu Ser 
                565                 570                 575 


<210>  406
<211>  576
<212>  PRT
<213>  Porcine respirovirus 1

<400>  406

Met Glu Glu Thr Lys Val Lys Thr Ser Glu Tyr Trp Ala Lys Ser Pro 
1               5                   10                  15      


Gln Thr His Thr Ala Ser His Leu Ser Ile Gln Asn Arg Glu Lys Thr 
            20                  25                  30          


Lys Glu Ile Leu Thr Ile Leu Ile Ser Phe Ile Thr Phe Leu Ser Phe 
        35                  40                  45              


Val Leu Ile Val Thr Val Leu Ile Ile Gln Ser Leu His Asn Gly Thr 
    50                  55                  60                  


Ile Leu Arg Cys Arg Asp Val Gly Leu Glu Ser Ile Asn Lys Ser Thr 
65                  70                  75                  80  


His Ser Ile Ser Asn Thr Ile Leu Asp Val Ile Arg Gln Glu Leu Ile 
                85                  90                  95      


Thr Arg Ile Ile Asn Thr Gln Ser Ser Val Gln Val Ala Leu Pro Val 
            100                 105                 110         


Leu Ile Asn Lys Lys Ile Gln Asp Leu Ser Leu Thr Ile Glu Lys Ser 
        115                 120                 125             


Leu Lys Val His Gln Asn Ser Pro Thr Cys Ser Gly Val Ala Ala Leu 
    130                 135                 140                 


Thr His Val Glu Gly Ile Lys Pro Leu Asp Pro Asp Asp Tyr Trp Arg 
145                 150                 155                 160 


Cys Pro Ser Gly Glu Pro Tyr Leu Glu Asp Glu Leu Thr Leu Asn Leu 
                165                 170                 175     


Ile Pro Gly Pro Ser Met Leu Val Gly Thr Ser Thr Ile Asp Gly Cys 
            180                 185                 190         


Val Arg Leu Pro Ser Leu Ala Ile Gly Lys Ser Leu Tyr Ala Tyr Ser 
        195                 200                 205             


Ser Asn Leu Ile Thr Lys Gly Cys Gln Asp Ile Gly Lys Ser Tyr Gln 
    210                 215                 220                 


Val Leu Gln Leu Gly Ile Ile Thr Leu Asn Ser Asp Leu His Pro Asp 
225                 230                 235                 240 


Leu Asn Pro Ile Ile Ser His Thr Tyr Asp Ile Asn Asp Asn Arg Lys 
                245                 250                 255     


Ser Cys Ser Val Ala Val Ser Glu Thr Lys Gly Tyr Gln Leu Cys Ser 
            260                 265                 270         


Met Pro Arg Val Asn Glu Lys Thr Asp Tyr Thr Ser Asp Gly Ile Glu 
        275                 280                 285             


Asp Ile Val Phe Asp Val Leu Asp Leu Lys Gly Ser Ser Arg Ser Phe 
    290                 295                 300                 


Lys Phe Ser Asn Asn Asp Ile Asn Phe Asp His Pro Phe Ser Ala Leu 
305                 310                 315                 320 


Tyr Pro Ser Val Gly Ser Gly Ile Ile Trp Glu Asn Glu Leu Tyr Phe 
                325                 330                 335     


Leu Gly Tyr Gly Ala Leu Thr Thr Ala Leu Gln Gly Asn Thr Lys Cys 
            340                 345                 350         


Asn Leu Val Gly Cys Pro Gly Ala Thr Gln Asp Asn Cys Asn Lys Phe 
        355                 360                 365             


Ile Ser Ser Ser Trp Leu Tyr Ser Lys Gln Met Val Asn Val Leu Ile 
    370                 375                 380                 


Gln Val Lys Gly Tyr Leu Ser Asn Lys Pro Ser Ile Lys Val Arg Thr 
385                 390                 395                 400 


Ile Pro Ile Thr Glu Asn Tyr Val Gly Ala Glu Gly Arg Leu Val Gly 
                405                 410                 415     


Thr Arg Glu Arg Ile Tyr Ile Tyr Thr Arg Ser Thr Gly Trp His Thr 
            420                 425                 430         


Asn Leu Gln Ile Gly Val Leu Asn Ile Asn His Pro Ile Thr Ile Thr 
        435                 440                 445             


Trp Thr Asp His Arg Ala Leu Ser Arg Pro Gly Arg Ser Pro Cys Ala 
    450                 455                 460                 


Trp Asn Asn Arg Cys Pro Arg Asn Cys Thr Thr Gly Val Tyr Thr Asp 
465                 470                 475                 480 


Ala Tyr Pro Ile Ser Pro Asp Ala Asn Tyr Val Ala Thr Val Thr Leu 
                485                 490                 495     


Leu Ser Asn Leu Thr Arg Thr Asn Pro Thr Ile Met Tyr Ser Ser Ser 
            500                 505                 510         


Asp Lys Val His Asn Met Leu Arg Leu Arg Asp Ala Glu Leu Glu Ala 
        515                 520                 525             


Ala Tyr Thr Thr Thr Ser Cys Ile Val His Phe Asp Arg Gly Tyr Cys 
    530                 535                 540                 


Phe His Ile Ile Glu Ile Asn Gln Lys Glu Leu Asn Thr Leu Gln Pro 
545                 550                 555                 560 


Met Leu Phe Lys Thr Ala Ile Pro Lys Ala Cys Arg Ile Ser Asn Leu 
                565                 570                 575     


<210>  407
<211>  557
<212>  PRT
<213>  Porcine respirovirus 1

<400>  407

Met Gln Val Thr Thr Leu Gly Leu Ala Ile Thr Leu Ser Ile Ala Ser 
1               5                   10                  15      


Leu Val Thr Ser Gln Val Pro Arg Asp Lys Leu Ala Asn Leu Gly Ile 
            20                  25                  30          


Ile Ile Lys Asp Ser Lys Ala Leu Lys Ile Ala Gly Ser Tyr Glu Asn 
        35                  40                  45              


Arg Tyr Ile Val Leu Ser Leu Val Pro Thr Ile Asp Asn Val Asn Gly 
    50                  55                  60                  


Cys Gly Ser Ile Gln Ile Ala Lys Tyr Lys Glu Met Leu Glu Arg Leu 
65                  70                  75                  80  


Leu Ile Pro Ile Lys Asp Ala Leu Asp Leu Gln Glu Ser Leu Ile Val 
                85                  90                  95      


Ile Asp Asn Glu Thr Thr Ala Asn Thr Tyr His Pro Gln Tyr Arg Phe 
            100                 105                 110         


Val Gly Ala Ile Ile Gly Thr Ile Ala Leu Gly Val Ala Thr Ala Ala 
        115                 120                 125             


Gln Val Thr Ala Gly Val Ala Leu Met Glu Ala Arg Glu Ala Lys Arg 
    130                 135                 140                 


Asp Ile Ser Met Leu Lys Glu Ala Met Glu Lys Thr Gln Asn Ser Ile 
145                 150                 155                 160 


Glu Lys Leu Gln Asn Ser Ala Gly Glu Gln Ile Leu Ala Leu Lys Met 
                165                 170                 175     


Leu Gln Asp Tyr Val Asn Gly Glu Ile Lys Pro Ala Ile Glu Glu Leu 
            180                 185                 190         


Gly Cys Glu Thr Ala Ala Leu Lys Leu Gly Ile Ala Leu Thr Gln His 
        195                 200                 205             


Tyr Thr Glu Leu Thr Asn Ala Phe Gly Ser Asn Leu Gly Ser Ile Gly 
    210                 215                 220                 


Glu Lys Ser Leu Thr Leu Gln Ala Leu Ser Ser Leu Tyr Lys Thr Asn 
225                 230                 235                 240 


Ile Thr Asp Ile Leu Thr Ala Thr Asn Leu Arg Lys Thr Asp Ile Tyr 
                245                 250                 255     


Asp Ile Ile Tyr Ala Glu Gln Val Lys Gly Arg Val Ile Asp Val Asp 
            260                 265                 270         


Leu Arg Arg Tyr Met Val Thr Ile Ser Ile Lys Ile Pro Ile Leu Ser 
        275                 280                 285             


Glu Ile Pro Gly Val Leu Ile Tyr Glu Val Ser Ser Ile Ser Tyr Asn 
    290                 295                 300                 


Ile Asp Gly Ala Glu Trp Tyr Ala Ala Val Pro Asp His Ile Leu Ser 
305                 310                 315                 320 


Lys Ser Ala Tyr Ile Gly Gly Ala Asp Val Ser Asp Cys Ile Glu Ser 
                325                 330                 335     


Gly Leu Thr Tyr Ile Cys Pro Arg Asp Pro Ala Gln Ile Ile Ala Asp 
            340                 345                 350         


Asn Gln Gln Lys Cys Phe Leu Gly His Leu Asp Lys Cys Pro Val Thr 
        355                 360                 365             


Lys Val Ile Asp Asn Leu Val Ser Lys Phe Ala Phe Ile Asn Gly Gly 
    370                 375                 380                 


Val Val Ala Asn Cys Ile Ala Ser Thr Cys Thr Cys Gly Glu Glu Arg 
385                 390                 395                 400 


Ile Gln Val Ser Gln Asp Arg Asp Lys Gly Val Thr Phe Leu Thr His 
                405                 410                 415     


Asn Asn Cys Gly Leu Ile Gly Val Asn Gly Val Glu Leu His Ala Asn 
            420                 425                 430         


Lys Lys Gly Ser Asp Ala Thr Trp Asn Val Ser Pro Ile Gly Val Gly 
        435                 440                 445             


Pro Ala Val Ser Leu Arg Pro Val Asp Ile Ser Leu Gln Ile Val Ala 
    450                 455                 460                 


Ala Thr Asn Phe Leu Asn Ser Ser Arg Lys Asp Leu Met Lys Ala Lys 
465                 470                 475                 480 


Glu Val Leu Asn Gln Val Gly Asn Leu Lys Asp Leu Thr Val Ile Thr 
                485                 490                 495     


Ile Ile Asn Ile Lys Ile Ile Ile Val Leu Leu Ile Cys Val Ile Gly 
            500                 505                 510         


Leu Gly Ile Leu Tyr His Gln Leu Arg Ser Ala Leu Glu Met Arg Asp 
        515                 520                 525             


Lys Met Ser Ala Leu Asn Asn Ser Ser Tyr Ser Leu Glu Pro Arg Thr 
    530                 535                 540                 


Val Gln Val Gln Val Met Lys Pro Ile Ser Phe Thr Arg 
545                 550                 555         


<210>  408
<211>  574
<212>  PRT
<213>  Squirrel respirovirus

<400>  408

Met Asp Lys Gly Lys Asn Thr Lys Glu Pro Tyr Trp Thr Ala Ser Ser 
1               5                   10                  15      


Asp Pro Asn Ile Pro Gly Ser Val Ser Asp Glu Leu His Leu Asn Arg 
            20                  25                  30          


Ser Leu Tyr Lys Ser Ala Leu Ile Ser Thr Thr Gln Leu Thr Ile Ser 
        35                  40                  45              


Leu Val Val Leu Val Leu Ser Ser Ile Ile Val Ala Arg Gln Ser Ser 
    50                  55                  60                  


Asn Ile Arg Asp Gly Pro Ala Ile Leu Glu Thr Val Asn Ile Ser His 
65                  70                  75                  80  


Lys Glu Met Lys Glu Ala Ile Met Asn Leu Ile Arg Gln Glu Val Ile 
                85                  90                  95      


Ala Arg Ser Ile Asn Ile Gln Ser Ser Val Gln Thr Gly Ile Pro Val 
            100                 105                 110         


Leu Leu Asn Lys Asn Thr Arg Asp Ile Ile Gln Thr Val Gly Lys Ser 
        115                 120                 125             


Cys Asn Arg Gln Glu Leu Thr Gln Leu Cys Glu Ser Thr Ile Ala Val 
    130                 135                 140                 


His His Ala Asp Gly Ile Thr Pro Leu Asn Pro His Glu Phe Trp Arg 
145                 150                 155                 160 


Cys Pro Ala Gly Glu Pro Tyr Leu Gly Gln Asp Pro Glu Ile Ser Leu 
                165                 170                 175     


Leu Pro Gly Pro Ser Leu Leu Ser Gly Ser Thr Thr Ile Ser Gly Cys 
            180                 185                 190         


Val Arg Leu Pro Ser Leu Ser Ile Gly Asp Thr Ile Tyr Ala Tyr Ser 
        195                 200                 205             


Ser Asn Leu Ile Thr Gln Gly Cys Ala Asn Ile Gly Lys Ser Tyr Gln 
    210                 215                 220                 


Val Leu Gln Leu Gly Tyr Ile Ser Leu Asn Ser Asp Met Phe Pro Asp 
225                 230                 235                 240 


Leu Asn Pro Val Val Ser His Thr Tyr Asp Ile Asn Asp Asn Arg Lys 
                245                 250                 255     


Ser Cys Ser Val Ile Ala Ala Gly Asn Lys Gly Tyr Gln Leu Cys Ser 
            260                 265                 270         


Met Pro Lys Val Asp Glu Arg Ala Asp Tyr Ala Ser Asp Gly Ile Glu 
        275                 280                 285             


Asp Leu Val Leu Asp Val Leu Asp Leu Lys Gly Arg Thr Arg Ser His 
    290                 295                 300                 


Arg Tyr Lys Asn Arg Asp Ile Asn Phe Asp His Pro Phe Ser Ser Leu 
305                 310                 315                 320 


Tyr Pro Ser Val Gly Ser Gly Val Ala Leu Gly Gln Ser Leu Ile Phe 
                325                 330                 335     


Leu Gly Tyr Gly Gly Leu Thr Thr Pro Leu Gln Gly Asn Thr Lys Cys 
            340                 345                 350         


Asn Leu Arg Gly Cys Arg Gln Val Ser Gln Glu Thr Cys Asn Glu Ala 
        355                 360                 365             


Leu Lys Val Thr Trp Leu Gly Gly Arg Gln Ile Val Asn Ala Ile Ile 
    370                 375                 380                 


Ser Val Thr Asn Tyr Leu Ser Asp Arg Pro Arg Ile Glu Val Thr Thr 
385                 390                 395                 400 


Ile Pro Ile Thr Gln Asn Tyr Leu Gly Ala Glu Gly Arg Leu Leu Lys 
                405                 410                 415     


Leu Gly Asp Lys Ile Tyr Ile Tyr Thr Arg Ser Ser Gly Trp His Ser 
            420                 425                 430         


Gln Leu Gln Ile Gly Val Leu Asp Met Gly Asn Pro Leu Thr Ile Thr 
        435                 440                 445             


Trp Thr Thr His Glu Phe Leu Ser Arg Pro Gly Asn Ala Glu Cys Asn 
    450                 455                 460                 


Trp Tyr Asn Thr Cys Pro Lys Glu Cys Ile Ser Gly Val Tyr Thr Asp 
465                 470                 475                 480 


Ala Tyr Pro Leu Ser Pro Asp Ala Ala Asn Val Ala Thr Val Thr Leu 
                485                 490                 495     


Tyr Ala Asn Thr Ser Arg Val Asn Pro Thr Ile Met Tyr Ser Asn Thr 
            500                 505                 510         


Thr Asn Ala Ile Asn Met Leu Arg Ile Gln Gly Val Asp Leu Glu Ala 
        515                 520                 525             


Ala Tyr Thr Thr Thr Ser Cys Val Thr His Phe Gly Lys Gly Tyr Cys 
    530                 535                 540                 


Phe His Ile Ile Glu Ile Asn Gln Lys Ser Leu Asn Thr Leu Gln Pro 
545                 550                 555                 560 


Met Leu Phe Lys Thr Ser Ile Pro Lys Leu Cys Asn Val Gly 
                565                 570                 


<210>  409
<211>  573
<212>  PRT
<213>  Squirrel respirovirus

<400>  409

Met Ala Ala Glu Ser Pro Asn Pro Val His Ile Ile Thr Ile Ser Leu 
1               5                   10                  15      


Ile Met Leu Thr Thr Leu Ser Gln Cys Gln Ile Pro Arg Asp Lys Leu 
            20                  25                  30          


Ser Asn Ile Gly Val Ile Ile Asp Glu Gly Lys Ala Leu Lys Ile Ala 
        35                  40                  45              


Gly Ser His Glu Ser Arg Tyr Ile Val Leu Ser Leu Val Pro Gly Val 
    50                  55                  60                  


Asp Thr Ser Asn Asp Cys Gly Thr Thr Gln Ile Val Gln Tyr Lys Asn 
65                  70                  75                  80  


Leu Leu Asn Arg Leu Leu Ile Pro Leu Arg Asp Ala Leu Asp Leu Gln 
                85                  90                  95      


Glu Ser Leu Ile Thr Val Thr Asn Glu Thr Ser Val Thr Pro Asp Leu 
            100                 105                 110         


Gly Gln Phe Arg Val Phe Gly Ala Val Ile Gly Thr Ile Ala Leu Gly 
        115                 120                 125             


Val Ala Ala Ser Ala Gln Ile Thr Ala Gly Val Ala Leu Ala Glu Val 
    130                 135                 140                 


Arg Glu Val Lys Arg Asp Ile Glu Leu Ile Lys Asp Ser Ile Ser Lys 
145                 150                 155                 160 


Thr His Lys Ser Ile Glu Phe Leu Gln Asn Ser Val Gly Glu Gln Ile 
                165                 170                 175     


Leu Ala Leu Lys Thr Leu Gln Asp Phe Val Asn Asp Glu Ile Lys Pro 
            180                 185                 190         


Ala Ile Asp Glu Leu Gly Cys Glu Thr Ala Ala Leu Arg Leu Gly Ile 
        195                 200                 205             


Lys Leu Ser Gln His Tyr Ser Glu Leu Leu Thr Ala Phe Gly Ser Asn 
    210                 215                 220                 


Leu Arg Thr Ile Gly Glu Lys Ser Leu Thr Leu Gln Ala Leu Ser Ser 
225                 230                 235                 240 


Leu Tyr Ser Thr Asn Ile Thr Glu Ile Met Thr Thr Val Asp Thr Gly 
                245                 250                 255     


Gln Ala Asn Ile Tyr Asp Ile Ile Tyr Thr Glu Gln Ile Lys Gly Thr 
            260                 265                 270         


Val Ile Asp Val Asp Leu Glu Arg Tyr Met Val Thr Leu Ser Val Lys 
        275                 280                 285             


Ile Pro Ile Leu Ser Glu Ile Pro Gly Val Leu Ile Tyr Arg Ala Ser 
    290                 295                 300                 


Ser Ile Ser Tyr Asn Ile Asp Gly Glu Glu Trp Tyr Val Thr Val Pro 
305                 310                 315                 320 


Ser His Ile Leu Ser Arg Thr Ser Phe Ile Gly Gly Ala Asn Ile Ala 
                325                 330                 335     


Glu Cys Val Glu Ser Arg Leu Ala Tyr Ile Cys Pro Arg Asp Pro Ala 
            340                 345                 350         


Gln Leu Ile Ser Pro Glu Gln Gln Arg Cys Leu Leu Gly Asp Thr Thr 
        355                 360                 365             


Ser Cys Pro Val Thr Arg Val Ile Asp Ser Leu Ile Pro Lys Phe Ala 
    370                 375                 380                 


Phe Leu Asn Gly Gly Val Val Ala Asn Cys Ile Ala Ser Thr Cys Thr 
385                 390                 395                 400 


Cys Gly Lys Ser Arg Arg Pro Val Ser Gln Asp Arg Ser Arg Gly Val 
                405                 410                 415     


Ile Phe Leu Thr Tyr Asp Asn Cys Gly Leu Ile Gly Val Asn Gly Ile 
            420                 425                 430         


Glu Leu Tyr Ala Asn Ser Lys Gly His Asp Ala Thr Trp Gly Asp His 
        435                 440                 445             


Asn Leu Thr Val Gly Pro Ala Val Ser Ile Lys Pro Ile Asp Ile Ser 
    450                 455                 460                 


Leu Asn Leu Ala Ala Ala Thr Asp Phe Leu Glu Asp Ser Arg Ala Glu 
465                 470                 475                 480 


Leu Glu Lys Ala Arg Lys Ile Leu Ala Glu Val Gly Gly Trp His Asn 
                485                 490                 495     


Ser Arg Thr Val Gln Ile Thr Ile Ile Val Leu Val Ile Leu Ile Leu 
            500                 505                 510         


Ile Val Met Ile Gly Val Ile Val Val Leu Tyr Lys Thr Arg Arg Thr 
        515                 520                 525             


Phe Val Asn Asn Asn Ala Gln Lys Glu Arg Leu Glu Asn Ile Tyr Thr 
    530                 535                 540                 


Leu Glu Pro Lys Thr Lys Tyr Met Tyr Thr Asn Gly Ala Phe Glu Pro 
545                 550                 555                 560 


Pro Ile Arg Gln Gly Arg Ala Pro Pro Ser Leu Tyr Ser 
                565                 570             


<210>  410
<211>  552
<212>  PRT
<213>  Salem salemvirus

<400>  410

Met Asn Pro Leu Asn Gln Thr Leu Ile Ala Lys Val Leu Gly Phe Leu 
1               5                   10                  15      


Leu Leu Ser Ser Ser Phe Thr Val Gly Gln Ile Gly Phe Glu Asn Leu 
            20                  25                  30          


Thr Arg Ile Gly Val His Gln Val Lys Gln Tyr Gly Tyr Lys Leu Ala 
        35                  40                  45              


His Tyr Asn Ser His Gln Leu Leu Leu Ile Arg Met Ile Pro Thr Val 
    50                  55                  60                  


Asn Gly Thr His Asn Cys Thr His Gln Val Ile Thr Arg Tyr Arg Glu 
65                  70                  75                  80  


Met Val Arg Glu Ile Ile Thr Pro Ile Lys Gly Ala Leu Asp Ile Met 
                85                  90                  95      


Lys Lys Ala Val Ser Pro Asp Leu Val Gly Ala Arg Ile Phe Gly Ala 
            100                 105                 110         


Ile Val Ala Gly Ala Ala Leu Gly Ile Ala Thr Ser Ala Gln Ile Thr 
        115                 120                 125             


Ala Gly Val Ala Leu His Arg Thr Lys Leu Asn Gly Gln Glu Ile Ser 
    130                 135                 140                 


Lys Leu Lys Glu Ala Val Ser Leu Thr Asn Glu Ala Val Glu Gln Leu 
145                 150                 155                 160 


Gln Tyr Ser Gln Gly Lys Ser Ile Leu Ala Ile Gln Gly Ile Gln Asp 
                165                 170                 175     


Phe Ile Asn Phe Asn Val Val Pro Leu Leu Glu Glu His Thr Cys Gly 
            180                 185                 190         


Ile Ala Lys Leu His Leu Glu Met Ala Leu Met Glu Tyr Phe Gln Lys 
        195                 200                 205             


Leu Ile Leu Val Phe Gly Pro Asn Leu Arg Asp Pro Ile Gly Ser Thr 
    210                 215                 220                 


Ile Gly Ile Gln Ala Leu Ala Thr Leu Phe Gln Asn Asn Met Phe Glu 
225                 230                 235                 240 


Val Ser Leu Arg Leu Gly Tyr Ala Gly Asp Asp Leu Glu Asp Val Leu 
                245                 250                 255     


Gln Ser Asn Ser Ile Arg Ala Asn Ile Ile Glu Ala Glu Pro Asp Ser 
            260                 265                 270         


Gly Phe Ile Val Leu Ala Ile Arg Tyr Pro Thr Leu Thr Leu Val Glu 
        275                 280                 285             


Asp Gln Val Ile Thr Glu Leu Ala His Ile Thr Phe Asn Asp Gly Pro 
    290                 295                 300                 


Gln Glu Trp Val Ala Thr Ile Pro Gln Phe Val Thr Tyr Arg Gly Leu 
305                 310                 315                 320 


Val Leu Ala Asn Ile Asp Val Ser Thr Cys Thr Phe Thr Glu Arg Asn 
                325                 330                 335     


Val Ile Cys Ala Arg Asp Gln Thr Tyr Pro Met Ile Ile Asp Leu Gln 
            340                 345                 350         


Leu Cys Met Arg Gly Asn Ile Ala Lys Cys Gly Arg Thr Arg Val Thr 
        355                 360                 365             


Gly Ser Thr Ala Ser Arg Phe Leu Leu Lys Asp Gly Asn Met Tyr Ala 
    370                 375                 380                 


Asn Cys Ile Ala Thr Met Cys Arg Cys Met Ser Ser Ser Ser Ile Ile 
385                 390                 395                 400 


Asn Gln Glu Pro Ser His Leu Thr Thr Leu Ile Val Lys Glu Thr Cys 
                405                 410                 415     


Ser Glu Val Met Ile Asp Thr Ile Arg Ile Thr Leu Gly Glu Arg Lys 
            420                 425                 430         


His Pro Pro Ile Asp Tyr Gln Thr Thr Ile Thr Leu Gly Gln Pro Ile 
        435                 440                 445             


Ala Leu Ala Pro Leu Asp Val Gly Thr Glu Leu Ala Asn Ala Val Ser 
    450                 455                 460                 


Tyr Leu Asn Lys Ser Lys Val Leu Leu Glu His Ser Asn Glu Val Leu 
465                 470                 475                 480 


Ser Ser Val Ser Thr Ala His Thr Ser Leu Thr Ala Thr Ile Val Leu 
                485                 490                 495     


Gly Ile Val Val Gly Gly Leu Ala Ile Leu Ile Val Val Met Phe Leu 
            500                 505                 510         


Phe Leu Glu Ala Gln Val Ile Lys Val Gln Arg Ala Met Met Leu Cys 
        515                 520                 525             


Pro Ile Thr Asn His Gly Tyr Leu Pro Asn Glu Asp Leu Leu Thr Arg 
    530                 535                 540                 


Gly His Ser Ile Pro Thr Ile Gly 
545                 550         


<210>  411
<211>  620
<212>  PRT
<213>  Salem salemvirus

<400>  411

Met Lys Ala Met His Tyr Tyr Lys Asn Asp Phe Ala Asp Pro Gly Thr 
1               5                   10                  15      


Asn Asp Asn Ser Ser Asp Leu Thr Thr Asn Pro Phe Ile Ser Asn Gln 
            20                  25                  30          


Ile Lys Ser Asn Leu Ser Pro Pro Val Leu Ala Glu Gly His Leu Ser 
        35                  40                  45              


Pro Ser Pro Ile Pro Lys Phe Arg Lys Ile Leu Leu Thr Ile Ser Phe 
    50                  55                  60                  


Val Ser Thr Ile Val Val Leu Thr Val Ile Leu Leu Val Leu Thr Ile 
65                  70                  75                  80  


Arg Ile Leu Thr Ile Ile Glu Ala Ser Ala Gly Asp Glu Lys Asp Ile 
                85                  90                  95      


His Thr Ile Leu Ser Ser Leu Leu Asn Thr Phe Met Asn Glu Tyr Ile 
            100                 105                 110         


Pro Val Phe Lys Asn Leu Val Ser Ile Ile Ser Leu Gln Ile Pro Gln 
        115                 120                 125             


Met Leu Ile Asp Leu Lys Thr Ser Ser Thr Gln Met Met Gln Ser Leu 
    130                 135                 140                 


Lys Thr Phe Pro Arg Asp Leu Glu Thr Leu Ser Thr Val Thr Gln Ser 
145                 150                 155                 160 


Val Ala Val Leu Leu Glu Lys Ala Lys Ser Thr Ile Pro Asp Ile Asn 
                165                 170                 175     


Lys Phe Tyr Lys Asn Val Gly Lys Val Thr Phe Asn Asp Pro Asn Ile 
            180                 185                 190         


Lys Val Leu Thr Leu Glu Val Pro Ala Trp Leu Pro Ile Val Arg Gln 
        195                 200                 205             


Cys Leu Lys Gln Asp Phe Arg Gln Val Ile Ser Asn Ser Thr Gly Phe 
    210                 215                 220                 


Ala Leu Ile Gly Ala Leu Pro Ser Gln Leu Phe Asn Glu Phe Glu Gly 
225                 230                 235                 240 


Tyr Pro Ser Leu Ala Ile Val Ser Glu Val Tyr Ala Ile Thr Tyr Leu 
                245                 250                 255     


Lys Gly Val Met Phe Glu Asn Gln Glu Asn Phe Leu Tyr Gln Tyr Phe 
            260                 265                 270         


Glu Ile Gly Thr Ile Ser Pro Asp Gly Tyr Asn Lys Pro Tyr Phe Leu 
        275                 280                 285             


Arg His Thr Ser Val Met Leu Ser Thr Phe Lys Leu Ser Gly Lys Cys 
    290                 295                 300                 


Thr Ala Ala Val Asp Tyr Arg Gly Gly Ile Phe Leu Cys Thr Pro Ser 
305                 310                 315                 320 


Pro Lys Ile Pro Lys Ile Leu Gln Asn Pro Pro Asp Leu Pro Thr Leu 
                325                 330                 335     


Thr Val Val Ser Ile Pro Phe Asp Gly Arg Tyr Thr Ile Arg Asn Ile 
            340                 345                 350         


Ser Leu Met Leu Thr Asp Glu Ala Asp Ile Ile Tyr Asp Leu Asp Thr 
        355                 360                 365             


Leu Gln Gly Arg Gly Val Leu Gln Ala Met Arg Phe Tyr Ala Leu Val 
    370                 375                 380                 


Arg Val Ile Ser Ser Ser Ser Pro Arg His Phe Pro Phe Cys Lys Asn 
385                 390                 395                 400 


Ser Trp Cys Pro Thr Ala Asp Asp Lys Ile Cys Asp Gln Ser Arg Arg 
                405                 410                 415     


Leu Gly Ala Asp Gly Asn Tyr Pro Val Met Tyr Gly Leu Ile Ser Ile 
            420                 425                 430         


Pro Ala His Ser Ser Tyr Gln Gly Asn Val Ser Leu Lys Leu Ile Asp 
        435                 440                 445             


Pro Lys Tyr Tyr Ala Tyr Thr Arg Asp Ala Ser Leu Phe Tyr Asn Ser 
    450                 455                 460                 


Met Thr Asp Thr Tyr His Tyr Ser Phe Gly Thr Arg Gly Trp Val Ser 
465                 470                 475                 480 


Arg Pro Ile Ile Gly Glu Leu Leu Leu Gly Asp Asp Ile Val Leu Thr 
                485                 490                 495     


Arg Tyr Thr Val Arg Ser Val Ser Arg Ala Thr Ala Gly Asp Cys Thr 
            500                 505                 510         


Thr Val Ser Met Cys Pro Gln Ala Cys Ser Gly Gly Met Asn Ser Ile 
        515                 520                 525             


Phe Tyr Pro Leu Asn Phe Asp Lys Pro Gln Val Thr Gly Val Ala Ile 
    530                 535                 540                 


Arg Gln Tyr Glu Arg Gln Gln Glu Gly Ile Ile Val Val Thr Met Asn 
545                 550                 555                 560 


Asp His Tyr Tyr Tyr Ser Val Pro Ile Ile Lys Asn Gly Thr Leu Leu 
                565                 570                 575     


Ile Ser Ser Val Thr Asp Cys Phe Trp Leu Met Gly Asp Leu Trp Cys 
            580                 585                 590         


Met Ser Leu Met Glu Lys Asn Asn Leu Pro Leu Gly Val Arg Ser Leu 
        595                 600                 605             


Ala His Leu Thr Trp Asn Ile His Trp Ser Cys Ser 
    610                 615                 620 


<210>  412
<211>  571
<212>  PRT
<213>  Human orthorubulavirus 2

<400>  412

Met Glu Asp Tyr Ser Asn Leu Ser Leu Lys Ser Ile Pro Lys Arg Thr 
1               5                   10                  15      


Cys Arg Ile Ile Phe Arg Thr Ala Thr Ile Leu Gly Ile Cys Thr Leu 
            20                  25                  30          


Ile Val Leu Cys Ser Ser Ile Leu His Glu Ile Ile His Leu Asp Val 
        35                  40                  45              


Ser Ser Gly Leu Met Asp Ser Asp Asp Ser Gln Gln Gly Ile Ile Gln 
    50                  55                  60                  


Pro Ile Ile Glu Ser Leu Lys Ser Leu Ile Ala Leu Ala Asn Gln Ile 
65                  70                  75                  80  


Leu Tyr Asn Val Ala Ile Ile Ile Pro Leu Lys Ile Asp Ser Ile Glu 
                85                  90                  95      


Thr Val Ile Phe Ser Ala Leu Lys Asp Met His Thr Gly Ser Met Ser 
            100                 105                 110         


Asn Thr Asn Cys Thr Pro Gly Asn Leu Leu Leu His Asp Ala Ala Tyr 
        115                 120                 125             


Ile Asn Gly Ile Asn Lys Phe Leu Val Leu Lys Ser Tyr Asn Gly Thr 
    130                 135                 140                 


Pro Lys Tyr Gly Pro Leu Leu Asn Ile Pro Ser Phe Ile Pro Ser Ala 
145                 150                 155                 160 


Thr Ser Pro Asn Gly Cys Thr Arg Ile Pro Ser Phe Ser Leu Ile Lys 
                165                 170                 175     


Thr His Trp Cys Tyr Thr His Asn Val Met Leu Gly Asp Cys Leu Asp 
            180                 185                 190         


Phe Thr Thr Ser Asn Gln Tyr Leu Ala Met Gly Ile Ile Gln Gln Ser 
        195                 200                 205             


Ala Ala Ala Phe Pro Ile Phe Arg Thr Met Lys Thr Ile Tyr Leu Ser 
    210                 215                 220                 


Asp Gly Ile Asn Arg Lys Ser Cys Ser Val Thr Ala Ile Pro Gly Gly 
225                 230                 235                 240 


Cys Val Leu Tyr Cys Tyr Val Ala Thr Arg Ser Glu Lys Glu Asp Tyr 
                245                 250                 255     


Ala Thr Thr Asp Leu Ala Glu Leu Arg Leu Ala Phe Tyr Tyr Tyr Asn 
            260                 265                 270         


Asp Thr Phe Ile Glu Arg Val Ile Ser Leu Pro Asn Thr Thr Gly Gln 
        275                 280                 285             


Trp Ala Thr Ile Asn Pro Ala Val Gly Ser Gly Ile Tyr His Leu Gly 
    290                 295                 300                 


Phe Ile Leu Phe Pro Val Tyr Gly Gly Leu Ile Ser Gly Thr Pro Ser 
305                 310                 315                 320 


Tyr Asn Lys Gln Ser Ser Arg Tyr Phe Ile Pro Lys His Pro Asn Ile 
                325                 330                 335     


Thr Cys Ala Gly Asn Ser Ser Glu Gln Ala Ala Ala Ala Arg Ser Ser 
            340                 345                 350         


Tyr Val Ile Arg Tyr His Ser Asn Arg Leu Ile Gln Ser Ala Val Leu 
        355                 360                 365             


Ile Cys Pro Leu Ser Asp Met His Thr Ala Arg Cys Asn Leu Val Met 
    370                 375                 380                 


Phe Asn Asn Ser Gln Val Met Met Gly Ala Glu Gly Arg Leu Tyr Val 
385                 390                 395                 400 


Ile Asp Asn Asn Leu Tyr Tyr Tyr Gln Arg Ser Ser Ser Trp Trp Ser 
                405                 410                 415     


Ala Ser Leu Phe Tyr Arg Ile Asn Thr Asp Phe Ser Lys Gly Ile Pro 
            420                 425                 430         


Pro Ile Ile Glu Ala Gln Trp Val Pro Ser Tyr Gln Val Pro Arg Pro 
        435                 440                 445             


Gly Val Met Pro Cys Asn Ala Thr Ser Phe Cys Pro Ala Asn Cys Ile 
    450                 455                 460                 


Thr Gly Val Tyr Ala Asp Val Trp Pro Leu Asn Asp Pro Glu Pro Thr 
465                 470                 475                 480 


Ser Gln Asn Ala Leu Asn Pro Asn Tyr Arg Phe Ala Gly Ala Phe Leu 
                485                 490                 495     


Arg Asn Glu Ser Asn Arg Thr Asn Pro Thr Phe Tyr Thr Ala Ser Ala 
            500                 505                 510         


Ser Ala Leu Leu Asn Thr Thr Gly Phe Asn Asn Thr Asn His Lys Ala 
        515                 520                 525             


Ala Tyr Thr Ser Ser Thr Cys Phe Lys Asn Thr Gly Thr Gln Lys Ile 
    530                 535                 540                 


Tyr Cys Leu Ile Ile Ile Glu Met Gly Ser Ser Leu Leu Gly Glu Phe 
545                 550                 555                 560 


Gln Ile Ile Pro Phe Leu Arg Glu Leu Ile Pro 
                565                 570     


<210>  413
<211>  551
<212>  PRT
<213>  Human orthorubulavirus 2

<400>  413

Met His His Leu His Pro Met Ile Val Cys Ile Phe Val Met Tyr Thr 
1               5                   10                  15      


Gly Ile Val Gly Ser Asp Ala Ile Ala Gly Asp Gln Leu Leu Asn Ile 
            20                  25                  30          


Gly Val Ile Gln Ser Lys Ile Arg Ser Leu Met Tyr Tyr Thr Asp Gly 
        35                  40                  45              


Gly Ala Ser Phe Ile Val Val Lys Leu Leu Pro Asn Leu Pro Pro Ser 
    50                  55                  60                  


Asn Gly Thr Cys Asn Ile Thr Ser Leu Asp Ala Tyr Asn Val Thr Leu 
65                  70                  75                  80  


Phe Lys Leu Leu Thr Pro Leu Ile Glu Asn Leu Ser Lys Ile Ser Thr 
                85                  90                  95      


Val Thr Asp Thr Lys Thr Arg Gln Lys Arg Phe Ala Gly Val Val Val 
            100                 105                 110         


Gly Leu Ala Ala Leu Gly Val Ala Thr Ala Ala Gln Ile Thr Ala Ala 
        115                 120                 125             


Val Ala Ile Val Lys Ala Asn Ala Asn Ala Ala Ala Ile Asn Asn Leu 
    130                 135                 140                 


Ala Ser Ser Ile Gln Ser Thr Asn Lys Ala Val Ser Asp Val Ile Asp 
145                 150                 155                 160 


Ala Ser Arg Thr Ile Ala Thr Ala Val Gln Ala Ile Gln Asp Arg Ile 
                165                 170                 175     


Asn Gly Ala Ile Val Asn Gly Ile Thr Ser Ala Ser Cys Arg Ala His 
            180                 185                 190         


Asp Ala Leu Ile Gly Ser Ile Leu Asn Leu Tyr Leu Thr Glu Leu Thr 
        195                 200                 205             


Thr Ile Phe His Asn Gln Ile Thr Asn Pro Ala Leu Thr Pro Leu Ser 
    210                 215                 220                 


Ile Gln Ala Leu Arg Ile Leu Leu Gly Ser Thr Leu Pro Ile Val Ile 
225                 230                 235                 240 


Glu Ser Lys Leu Asn Thr Asn Phe Asn Thr Ala Glu Leu Leu Ser Ser 
                245                 250                 255     


Gly Leu Leu Thr Gly Gln Ile Ile Ser Ile Ser Pro Met Tyr Met Gln 
            260                 265                 270         


Met Leu Ile Gln Ile Asn Val Pro Thr Phe Ile Met Gln Pro Gly Ala 
        275                 280                 285             


Lys Val Ile Asp Leu Ile Ala Ile Ser Ala Asn His Lys Leu Gln Glu 
    290                 295                 300                 


Val Val Val Gln Val Pro Asn Arg Ile Leu Glu Tyr Ala Asn Glu Leu 
305                 310                 315                 320 


Gln Asn Tyr Pro Ala Asn Asp Cys Val Val Thr Pro Asn Ser Val Phe 
                325                 330                 335     


Cys Arg Tyr Asn Glu Gly Ser Pro Ile Pro Glu Ser Gln Tyr Gln Cys 
            340                 345                 350         


Leu Arg Gly Asn Leu Asn Ser Cys Thr Phe Thr Pro Ile Ile Gly Asn 
        355                 360                 365             


Phe Leu Lys Arg Phe Ala Phe Ala Asn Gly Val Leu Tyr Ala Asn Cys 
    370                 375                 380                 


Lys Ser Leu Leu Cys Arg Cys Ala Asp Pro Pro His Val Val Ser Gln 
385                 390                 395                 400 


Asp Asp Thr Gln Gly Ile Ser Ile Ile Asp Ile Lys Arg Cys Ser Glu 
                405                 410                 415     


Met Met Leu Asp Thr Phe Ser Phe Arg Ile Thr Ser Thr Phe Asn Ala 
            420                 425                 430         


Thr Tyr Val Thr Asp Phe Ser Met Ile Asn Ala Asn Ile Val His Leu 
        435                 440                 445             


Ser Pro Leu Asp Leu Ser Asn Gln Ile Asn Ser Ile Asn Lys Ser Leu 
    450                 455                 460                 


Lys Ser Ala Glu Asp Trp Ile Ala Asp Ser Asn Phe Phe Ala Asn Gln 
465                 470                 475                 480 


Ala Arg Thr Ala Lys Thr Leu Tyr Ser Leu Ser Ala Ile Ala Leu Ile 
                485                 490                 495     


Leu Ser Val Ile Thr Leu Val Val Val Gly Leu Leu Ile Ala Tyr Ile 
            500                 505                 510         


Ile Lys Leu Val Ser Gln Ile His Gln Phe Arg Ser Leu Ala Ala Thr 
        515                 520                 525             


Thr Met Phe His Arg Glu Asn Pro Ala Phe Phe Ser Lys Asn Asn His 
    530                 535                 540                 


Gly Asn Ile Tyr Gly Ile Ser 
545                 550     


<210>  414
<211>  573
<212>  PRT
<213>  Human orthorubulavirus 4

<400>  414

Met Gln Asp Ser His Gly Asn Thr Gln Ile Leu Asn Gln Ala Asn Ser 
1               5                   10                  15      


Met Val Lys Arg Thr Trp Arg Leu Leu Phe Arg Ile Ala Thr Leu Ile 
            20                  25                  30          


Leu Leu Val Ser Ile Phe Val Leu Ser Leu Ile Ile Val Leu Gln Ser 
        35                  40                  45              


Thr Pro Gly Asn Leu Gln Asn Asp Ile Asn Ile Ile Arg Lys Glu Leu 
    50                  55                  60                  


Asn Glu Leu Met Glu Asn Phe Glu Thr Thr Ser Lys Ser Leu Leu Ser 
65                  70                  75                  80  


Val Ser Asn Gln Ile Thr Tyr Asp Val Ser Val Leu Thr Pro Ile Arg 
                85                  90                  95      


Gln Glu Ala Ile Glu Thr Asn Ile Ile Ser Lys Ile Lys Asp His Cys 
            100                 105                 110         


Lys Asp Arg Val Ile Lys Glu Gly Ser Thr Cys Thr Leu Asn Arg Ser 
        115                 120                 125             


Pro Leu His Asp Val Ser Phe Leu Asn Gly Phe Asn Lys Phe Tyr Phe 
    130                 135                 140                 


Thr Tyr Lys Asp Asn Met Gln Ile Lys Phe Lys Ser Leu Leu Asp Tyr 
145                 150                 155                 160 


Pro Asn Phe Ile Pro Thr Ala Thr Thr Pro His Gly Cys Ile Arg Ile 
                165                 170                 175     


Pro Ser Phe Ser Leu Gly Gln Thr His Trp Cys Tyr Thr His Asn Ile 
            180                 185                 190         


Asn Leu Leu Gly Cys Ala Asp Pro Ala Ser Ser Asn Gln Tyr Val Ser 
        195                 200                 205             


Leu Gly Thr Leu Gln Val Leu Lys Met Gly Asp Pro Tyr Phe Lys Val 
    210                 215                 220                 


Glu His Ser His Tyr Leu Asn Asp Gly Arg Asn Arg Lys Ser Cys Ser 
225                 230                 235                 240 


Val Val Ala Val Pro Asp Gly Cys Leu Arg Asn Cys Val Thr Met Thr 
                245                 250                 255     


Lys Asn Glu Thr Glu Asn Phe Lys Asp Leu Asn Trp Gln His Asn Tyr 
            260                 265                 270         


Leu His Thr Tyr His Ile Met Val Pro Leu Lys Thr Arg Ile Ile Asn 
        275                 280                 285             


Pro Pro Gly Ser Ser Arg Asp Trp Val His Ile Ala Pro Gly Val Gly 
    290                 295                 300                 


Ser Gly Leu Leu Tyr Ala Lys Leu Leu Ile Phe Pro Leu Tyr Gly Gly 
305                 310                 315                 320 


Leu Thr Glu Lys Ser Val Ile His Asn Asn Gln Ser Gly Lys Tyr Phe 
                325                 330                 335     


Phe Pro Asn Ser Thr Lys Leu Gln Cys Arg Asn Ser Thr Met Glu Lys 
            340                 345                 350         


Ile Lys Gly Ala Lys Asp Ser Tyr Thr Ile Thr Tyr Phe Ser Gly Arg 
        355                 360                 365             


Leu Ile Gln Ser Ala Phe Leu Val Cys Asp Leu Arg Gln Phe Leu Ser 
    370                 375                 380                 


Glu Asp Cys Glu Ile Leu Ile Pro Ser Asn Asp Tyr Met Met Val Gly 
385                 390                 395                 400 


Ala Glu Gly Arg Leu Tyr Asn Ile Glu Asn Asn Ile Phe Tyr Tyr Gln 
                405                 410                 415     


Arg Gly Ser Ser Trp Trp Pro Tyr Pro Ser Leu Tyr Arg Ile Arg Leu 
            420                 425                 430         


Asn Leu Ser Lys Lys Tyr Pro Arg Ile Thr Glu Ile Lys Phe Thr Lys 
        435                 440                 445             


Ile Glu Ile Ala Pro Arg Pro Gly Asn Lys Asp Cys Pro Gly Asn Lys 
    450                 455                 460                 


Ala Cys Pro Lys Glu Cys Ile Thr Gly Val Tyr Gln Asp Ile Leu Pro 
465                 470                 475                 480 


Leu Ser Tyr Pro Asn Thr Ala Phe Pro His Leu Lys Gln Ala Tyr Tyr 
                485                 490                 495     


Thr Gly Phe Tyr Leu Asn Asn Ser Leu Glu Arg Arg Asn Pro Thr Phe 
            500                 505                 510         


Tyr Thr Ala Asp Asn Leu Asp Tyr His Gln Gln Glu Arg Leu Gly Lys 
        515                 520                 525             


Phe Asn Leu Thr Ala Gly Tyr Ser Thr Thr Thr Cys Phe Lys Gln Thr 
    530                 535                 540                 


Thr Thr Ala Arg Leu Tyr Cys Leu Tyr Ile Ile Glu Val Gly Asp Ser 
545                 550                 555                 560 


Val Ile Gly Asp Phe Gln Ile Thr Leu Phe Leu Ala Ala 
                565                 570             


<210>  415
<211>  544
<212>  PRT
<213>  Human orthorubulavirus 4

<400>  415

Met Gly Val Lys Gly Ser Ser Leu Ile Met Ile Gly Leu Leu Ile Ser 
1               5                   10                  15      


Pro Ile Thr Asn Leu Asp Ile Thr His Leu Met Asn Leu Gly Thr Val 
            20                  25                  30          


Pro Thr Ala Ile Arg Ser Leu Val Tyr Tyr Thr Tyr Thr Lys Pro Ser 
        35                  40                  45              


Tyr Leu Thr Val Asp Leu Ile Pro Asn Leu Lys Asn Leu Asp Gln Asn 
    50                  55                  60                  


Cys Asn Tyr Ser Ser Leu Asn Tyr Tyr Asn Lys Thr Ala Leu Ser Leu 
65                  70                  75                  80  


Ile Gln Pro Ile Ala Asp Asn Ile Asn Arg Leu Thr Lys Pro Ile Ala 
                85                  90                  95      


Ser Ser Glu Val Gln Ser Arg Phe Phe Gly Ala Val Ile Gly Thr Ile 
            100                 105                 110         


Ala Leu Gly Val Ala Thr Ala Ala Gln Val Thr Ala Ala Ile Gly Leu 
        115                 120                 125             


Ala Lys Ala Gln Glu Asn Ala Lys Leu Ile Leu Thr Leu Lys Lys Ala 
    130                 135                 140                 


Ala Thr Glu Thr Asn Glu Ala Val Arg Asp Leu Ala Asn Ser Asn Lys 
145                 150                 155                 160 


Ile Val Val Lys Met Ile Ser Ala Ile Gln Asn Gln Ile Asn Thr Ile 
                165                 170                 175     


Ile Gln Pro Ala Ile Asp Gln Ile Asn Cys Gln Ile Lys Asp Leu Gln 
            180                 185                 190         


Val Ala Asn Ile Leu Asn Leu Tyr Leu Thr Glu Ile Thr Thr Val Phe 
        195                 200                 205             


His Asn Gln Leu Thr Asn Pro Ala Leu Glu Ser Ile Ser Ile Gln Ala 
    210                 215                 220                 


Leu Lys Ser Leu Leu Gly Ser Thr Leu Pro Glu Val Leu Ser Lys Leu 
225                 230                 235                 240 


Asp Leu Asn Asn Ile Ser Ala Ala Ser Val Met Ala Ser Gly Leu Ile 
                245                 250                 255     


Lys Gly Gln Ile Ile Ala Val Asp Ile Pro Thr Met Thr Leu Val Leu 
            260                 265                 270         


Met Val Gln Ile Pro Ser Ile Ser Pro Leu Arg Gln Ala Lys Ile Ile 
        275                 280                 285             


Asp Leu Thr Ser Ile Thr Ile His Thr Asn Ser Gln Glu Val Gln Ala 
    290                 295                 300                 


Val Val Pro Ala Arg Phe Leu Glu Ile Gly Ser Glu Ile Leu Gly Phe 
305                 310                 315                 320 


Asp Gly Ser Val Cys Gln Ile Thr Lys Asp Thr Ile Phe Cys Pro Tyr 
                325                 330                 335     


Asn Asp Ala Tyr Val Leu Pro Ile Gln Gln Lys Arg Cys Leu Gln Gly 
            340                 345                 350         


Gln Thr Arg Asp Cys Val Phe Thr Pro Val Ala Gly Thr Phe Pro Arg 
        355                 360                 365             


Arg Phe Leu Thr Thr Tyr Gly Thr Ile Val Ala Asn Cys Arg Asp Leu 
    370                 375                 380                 


Val Cys Ser Cys Leu Arg Pro Pro Gln Ile Ile Tyr Gln Pro Asp Glu 
385                 390                 395                 400 


Asn Pro Val Thr Ile Ile Asp Lys Asp Leu Cys Thr Thr Leu Thr Leu 
                405                 410                 415     


Asp Ser Ile Thr Ile Glu Ile Gln Lys Ser Ile Asn Ser Thr Phe Arg 
            420                 425                 430         


Arg Glu Val Val Leu Glu Ser Thr Gln Val Arg Ser Leu Thr Pro Leu 
        435                 440                 445             


Asp Leu Ser Thr Asp Leu Asn Gln Tyr Asn Gln Leu Leu Lys Ser Ala 
    450                 455                 460                 


Glu Asp His Ile Gln Arg Ser Thr Asp Tyr Leu Asn Ser Ile Asn Pro 
465                 470                 475                 480 


Ser Ile Val Asn Asn Asn Ala Ile Ile Ile Leu Ile Ile Leu Cys Ile 
                485                 490                 495     


Leu Leu Ile Leu Thr Val Thr Ile Cys Ile Ile Trp Leu Lys Tyr Leu 
            500                 505                 510         


Thr Asn Glu Val Lys Asn Val Ala Arg Asn Gln Arg Leu Asn Arg Asp 
        515                 520                 525             


Ala Asp Leu Phe His Arg Ile Pro Ser Gln Ile Pro Val Pro Arg Gln 
    530                 535                 540                 


<210>  416
<211>  565
<212>  PRT
<213>  Mammalian orthorubulavirus 5

<400>  416

Met Val Ala Glu Asp Ala Pro Val Arg Ala Thr Cys Arg Val Leu Phe 
1               5                   10                  15      


Arg Thr Thr Thr Leu Ile Phe Leu Cys Thr Leu Leu Ala Leu Ser Ile 
            20                  25                  30          


Ser Ile Leu Tyr Glu Ser Leu Ile Thr Gln Lys Gln Ile Met Ser Gln 
        35                  40                  45              


Ala Gly Ser Thr Gly Ser Asn Ser Gly Leu Gly Ser Ile Thr Asp Leu 
    50                  55                  60                  


Leu Asn Asn Ile Leu Ser Val Ala Asn Gln Ile Ile Tyr Asn Ser Ala 
65                  70                  75                  80  


Val Ala Leu Pro Leu Gln Leu Asp Thr Leu Glu Ser Thr Leu Leu Thr 
                85                  90                  95      


Ala Ile Lys Ser Leu Gln Thr Ser Asp Lys Leu Glu Gln Asn Cys Ser 
            100                 105                 110         


Trp Ser Ala Ala Leu Ile Asn Asp Asn Arg Tyr Ile Asn Gly Ile Asn 
        115                 120                 125             


Gln Phe Tyr Phe Ser Ile Ala Glu Gly Arg Asn Leu Thr Leu Gly Pro 
    130                 135                 140                 


Leu Leu Asn Met Pro Ser Phe Ile Pro Thr Ala Thr Thr Pro Glu Gly 
145                 150                 155                 160 


Cys Thr Arg Ile Pro Ser Phe Ser Leu Thr Lys Thr His Trp Cys Tyr 
                165                 170                 175     


Thr His Asn Val Ile Leu Asn Gly Cys Gln Asp His Val Ser Ser Asn 
            180                 185                 190         


Gln Phe Val Ser Met Gly Ile Ile Glu Pro Thr Ser Ala Gly Phe Pro 
        195                 200                 205             


Phe Phe Arg Thr Leu Lys Thr Leu Tyr Leu Ser Asp Gly Val Asn Arg 
    210                 215                 220                 


Lys Ser Cys Ser Ile Ser Thr Val Pro Gly Gly Cys Met Met Tyr Cys 
225                 230                 235                 240 


Phe Val Ser Thr Gln Pro Glu Arg Asp Asp Tyr Phe Ser Ala Ala Pro 
                245                 250                 255     


Pro Glu Gln Arg Ile Ile Ile Met Tyr Tyr Asn Asp Thr Ile Val Glu 
            260                 265                 270         


Arg Ile Ile Asn Pro Pro Gly Val Leu Asp Val Trp Ala Thr Leu Asn 
        275                 280                 285             


Pro Gly Thr Gly Ser Gly Val Tyr Tyr Leu Gly Trp Val Leu Phe Pro 
    290                 295                 300                 


Ile Tyr Gly Gly Val Ile Lys Gly Thr Ser Leu Trp Asn Asn Gln Ala 
305                 310                 315                 320 


Asn Lys Tyr Phe Ile Pro Gln Met Val Ala Ala Leu Cys Ser Gln Asn 
                325                 330                 335     


Gln Ala Thr Gln Val Gln Asn Ala Lys Ser Ser Tyr Tyr Ser Ser Trp 
            340                 345                 350         


Phe Gly Asn Arg Met Ile Gln Ser Gly Ile Leu Ala Cys Pro Leu Arg 
        355                 360                 365             


Gln Asp Leu Thr Asn Glu Cys Leu Val Leu Pro Phe Ser Asn Asp Gln 
    370                 375                 380                 


Val Leu Met Gly Ala Glu Gly Arg Leu Tyr Met Tyr Gly Asp Ser Val 
385                 390                 395                 400 


Tyr Tyr Tyr Gln Arg Ser Asn Ser Trp Trp Pro Met Thr Met Leu Tyr 
                405                 410                 415     


Lys Val Thr Ile Thr Phe Thr Asn Gly Gln Pro Ser Ala Ile Ser Ala 
            420                 425                 430         


Gln Asn Val Pro Thr Gln Gln Val Pro Arg Pro Gly Thr Gly Asp Cys 
        435                 440                 445             


Ser Ala Thr Asn Arg Cys Pro Gly Phe Cys Leu Thr Gly Val Tyr Ala 
    450                 455                 460                 


Asp Ala Trp Leu Leu Thr Asn Pro Ser Ser Thr Ser Thr Phe Gly Ser 
465                 470                 475                 480 


Glu Ala Thr Phe Thr Gly Ser Tyr Leu Asn Thr Ala Thr Gln Arg Ile 
                485                 490                 495     


Asn Pro Thr Met Tyr Ile Ala Asn Asn Thr Gln Ile Ile Ser Ser Gln 
            500                 505                 510         


Gln Phe Gly Ser Ser Gly Gln Glu Ala Ala Tyr Gly His Thr Thr Cys 
        515                 520                 525             


Phe Arg Asp Thr Gly Ser Val Met Val Tyr Cys Ile Tyr Ile Ile Glu 
    530                 535                 540                 


Leu Ser Ser Ser Leu Leu Gly Gln Phe Gln Ile Val Pro Phe Ile Arg 
545                 550                 555                 560 


Gln Val Thr Leu Ser 
                565 


<210>  417
<211>  529
<212>  PRT
<213>  Mammalian orthorubulavirus 5

<400>  417

Met Gly Thr Ile Ile Gln Phe Leu Val Val Ser Cys Leu Leu Ala Gly 
1               5                   10                  15      


Ala Gly Ser Leu Asp Pro Ala Ala Leu Met Gln Ile Gly Val Ile Pro 
            20                  25                  30          


Thr Asn Val Arg Gln Leu Met Tyr Tyr Thr Glu Ala Ser Ser Ala Phe 
        35                  40                  45              


Ile Val Val Lys Leu Met Pro Thr Ile Asp Ser Pro Ile Ser Gly Cys 
    50                  55                  60                  


Asn Ile Thr Ser Ile Ser Ser Tyr Asn Ala Thr Val Thr Lys Leu Leu 
65                  70                  75                  80  


Gln Pro Ile Gly Glu Asn Leu Glu Thr Ile Arg Asn Gln Leu Ile Pro 
                85                  90                  95      


Thr Arg Arg Arg Arg Arg Phe Ala Gly Val Val Ile Gly Leu Ala Ala 
            100                 105                 110         


Leu Gly Val Ala Thr Ala Ala Gln Val Thr Ala Ala Val Ala Leu Val 
        115                 120                 125             


Lys Ala Asn Glu Asn Ala Ala Ala Ile Leu Asn Leu Lys Asn Ala Ile 
    130                 135                 140                 


Gln Lys Thr Asn Ala Ala Val Ala Asp Val Val Gln Ala Thr Gln Ser 
145                 150                 155                 160 


Leu Gly Thr Ala Val Gln Ala Val Gln Asp His Ile Asn Ser Val Val 
                165                 170                 175     


Ser Pro Ala Ile Thr Ala Ala Asn Cys Lys Ala Gln Asp Ala Ile Ile 
            180                 185                 190         


Gly Ser Ile Leu Asn Leu Tyr Leu Thr Glu Leu Thr Thr Ile Phe His 
        195                 200                 205             


Asn Gln Ile Thr Asn Pro Ala Leu Ser Pro Ile Thr Ile Gln Ala Leu 
    210                 215                 220                 


Arg Ile Leu Leu Gly Ser Thr Leu Pro Thr Val Val Glu Lys Ser Phe 
225                 230                 235                 240 


Asn Thr Gln Ile Ser Ala Ala Glu Leu Leu Ser Ser Gly Leu Leu Thr 
                245                 250                 255     


Gly Gln Ile Val Gly Leu Asp Leu Thr Tyr Met Gln Met Val Ile Lys 
            260                 265                 270         


Ile Glu Leu Pro Thr Leu Thr Val Gln Pro Ala Thr Gln Ile Ile Asp 
        275                 280                 285             


Leu Ala Thr Ile Ser Ala Phe Ile Asn Asn Gln Glu Val Met Ala Gln 
    290                 295                 300                 


Leu Pro Thr Arg Val Met Val Thr Gly Ser Leu Ile Gln Ala Tyr Pro 
305                 310                 315                 320 


Ala Ser Gln Cys Thr Ile Thr Pro Asn Thr Val Tyr Cys Arg Tyr Asn 
                325                 330                 335     


Asp Ala Gln Val Leu Ser Asp Asp Thr Met Ala Cys Leu Gln Gly Asn 
            340                 345                 350         


Leu Thr Arg Cys Thr Phe Ser Pro Val Val Gly Ser Phe Leu Thr Arg 
        355                 360                 365             


Phe Val Leu Phe Asp Gly Ile Val Tyr Ala Asn Cys Arg Ser Met Leu 
    370                 375                 380                 


Cys Lys Cys Met Gln Pro Ala Ala Val Ile Leu Gln Pro Ser Ser Ser 
385                 390                 395                 400 


Pro Val Thr Val Ile Asp Met Tyr Lys Cys Val Ser Leu Gln Leu Asp 
                405                 410                 415     


Asn Leu Arg Phe Thr Ile Thr Gln Leu Ala Asn Val Thr Tyr Asn Ser 
            420                 425                 430         


Thr Ile Lys Leu Glu Ser Ser Gln Ile Leu Ser Ile Asp Pro Leu Asp 
        435                 440                 445             


Ile Ser Gln Asn Leu Ala Ala Val Asn Lys Ser Leu Ser Asp Ala Leu 
    450                 455                 460                 


Gln His Leu Ala Gln Ser Asp Thr Tyr Leu Ser Ala Ile Thr Ser Ala 
465                 470                 475                 480 


Thr Thr Thr Ser Val Leu Ser Ile Ile Ala Ile Cys Leu Gly Ser Leu 
                485                 490                 495     


Gly Leu Ile Leu Ile Ile Leu Leu Ser Val Val Val Trp Lys Leu Leu 
            500                 505                 510         


Thr Ile Val Val Ala Asn Arg Asn Arg Met Glu Asn Phe Val Tyr His 
        515                 520                 525             


Lys 
    


<210>  418
<211>  537
<212>  PRT
<213>  Mapuera orthorubulavirus

<400>  418

Met Arg Ser Ser Leu Phe Leu Val Leu Thr Leu Leu Val Pro Phe Ala 
1               5                   10                  15      


His Ser Ile Asp Ser Ile Thr Leu Glu Gln Tyr Gly Thr Val Ile Thr 
            20                  25                  30          


Ser Val Arg Ser Leu Ala Tyr Phe Leu Glu Thr Asn Pro Thr Tyr Ile 
        35                  40                  45              


Ser Val Arg Leu Met Pro Ala Ile Gln Thr Asp Ser Ser His Cys Ser 
    50                  55                  60                  


Tyr His Ser Ile Glu Asn Tyr Asn Leu Thr Leu Thr Lys Leu Leu Leu 
65                  70                  75                  80  


Pro Leu Gln Glu Asn Leu His Gln Ile Thr Asp Ser Leu Ser Ser Arg 
                85                  90                  95      


Arg Arg Lys Lys Arg Phe Ala Gly Val Ala Val Gly Leu Ala Ala Leu 
            100                 105                 110         


Gly Val Ala Thr Ala Ala Gln Val Thr Ala Ala Ile Ala Val Val Lys 
        115                 120                 125             


Ala Lys Glu Asn Ser Ala Lys Ile Ala Gln Leu Thr Ser Ala Ile Ser 
    130                 135                 140                 


Glu Thr Asn Arg Ala Val Gln Asp Leu Ile Glu Gly Ser Lys Gln Leu 
145                 150                 155                 160 


Ala Val Ala Val Gln Ala Ile Gln Asp Gln Ile Asn Asn Val Ile Gln 
                165                 170                 175     


Pro Gln Leu Thr Asn Leu Ser Cys Gln Val Ala Asp Ala Gln Val Gly 
            180                 185                 190         


Thr Ile Leu Asn Met Tyr Leu Thr Glu Leu Thr Thr Val Phe His Pro 
        195                 200                 205             


Gln Ile Thr Asn Ser Ala Leu Thr Pro Ile Thr Ile Gln Ala Leu Arg 
    210                 215                 220                 


Ser Leu Leu Gly Ser Thr Leu Pro Gln Val Val Thr Ser Thr Ile Lys 
225                 230                 235                 240 


Thr Asp Val Pro Leu Gln Asp Leu Leu Thr Ser Gly Leu Leu Lys Gly 
                245                 250                 255     


Gln Ile Val Tyr Leu Asp Leu Gln Ser Met Ile Met Val Val Ser Val 
            260                 265                 270         


Ser Val Pro Thr Ile Ala Leu His Ser Met Ala Lys Val Tyr Thr Leu 
        275                 280                 285             


Lys Ala Ile Ser Ala His Val Asn Asn Ala Glu Val Gln Met Gln Val 
    290                 295                 300                 


Pro Ser Arg Val Met Glu Leu Gly Ser Glu Ile Met Gly Tyr Asp Ile 
305                 310                 315                 320 


Asp Gln Cys Glu Glu Thr Ser Arg Tyr Leu Phe Cys Pro Tyr Asn Gly 
                325                 330                 335     


Gly Ser Ile Leu Ser Ala Thr Met Lys Met Cys Leu Asn Gly Asn Ile 
            340                 345                 350         


Ser Gln Cys Val Phe Thr Pro Ile Tyr Gly Ser Phe Leu Gln Arg Phe 
        355                 360                 365             


Val Leu Val Asp Gly Val Ile Val Ala Asn Cys Arg Asp Met Thr Cys 
    370                 375                 380                 


Ala Cys Lys Ser Pro Ser Lys Ile Ile Thr Gln Pro Asp Ser Leu Pro 
385                 390                 395                 400 


Val Thr Ile Ile Asp Ser Thr Ser Cys Ser Asn Leu Val Leu Asp Thr 
                405                 410                 415     


Leu Glu Leu Pro Ile Ile Ser Ile Asn Asn Ala Thr Tyr Arg Pro Val 
            420                 425                 430         


Gln Tyr Val Gly Pro Asn Gln Ile Ile Phe Ser Gln Pro Leu Asp Leu 
        435                 440                 445             


Leu Ser Gln Leu Gly Lys Ile Asn Ser Ser Leu Ser Asp Ala Ile Glu 
    450                 455                 460                 


His Leu Ala Lys Ser Asp Glu Ile Leu Glu Gln Ile Gln Trp Asp Ser 
465                 470                 475                 480 


Pro Gln Gly Tyr Thr Leu Ile Ala Leu Thr Ser Val Leu Ala Phe Val 
                485                 490                 495     


Val Val Ala Ile Val Gly Leu Leu Ile Ser Thr Arg Tyr Leu Ile Phe 
            500                 505                 510         


Glu Ile Arg Arg Ile Asn Thr Thr Leu Thr Gln Gln Leu Ser Ser Tyr 
        515                 520                 525             


Val Leu Ser Asn Lys Ile Ile Gln Tyr 
    530                 535         


<210>  419
<211>  582
<212>  PRT
<213>  Mapuera orthorubulavirus

<400>  419

Met Ala Ser Leu Gln Ser Glu Pro Gly Ser Gln Lys Pro His Tyr Gln 
1               5                   10                  15      


Ser Asp Asp Gln Leu Val Lys Arg Thr Trp Arg Ser Phe Phe Arg Phe 
            20                  25                  30          


Ser Val Leu Val Val Thr Ile Thr Ser Leu Ala Leu Ser Ile Ile Thr 
        35                  40                  45              


Leu Ile Gly Val Asn Arg Ile Ser Thr Ala Lys Gln Ile Ser Asn Ala 
    50                  55                  60                  


Phe Ala Ala Ile Gln Ala Asn Ile Leu Ser Ser Ile Pro Asp Ile Arg 
65                  70                  75                  80  


Pro Ile Asn Ser Leu Leu Asn Gln Leu Val Tyr Thr Ser Ser Val Thr 
                85                  90                  95      


Leu Pro Leu Arg Ile Ser Ser Leu Glu Ser Asn Val Leu Ala Ala Ile 
            100                 105                 110         


Gln Glu Ala Cys Thr Tyr Arg Asp Ser Gln Ser Ser Cys Ser Ala Thr 
        115                 120                 125             


Met Ser Val Met Asn Asp Gln Arg Tyr Ile Glu Gly Ile Gln Val Tyr 
    130                 135                 140                 


Ser Gly Ser Phe Leu Asp Leu Gln Lys His Thr Leu Ser Pro Pro Ile 
145                 150                 155                 160 


Ala Phe Pro Ser Phe Ile Pro Thr Ser Thr Thr Thr Val Gly Cys Thr 
                165                 170                 175     


Arg Ile Pro Ser Phe Ser Leu Thr Lys Thr His Trp Cys Tyr Thr His 
            180                 185                 190         


Asn Tyr Ile Lys Thr Gly Cys Arg Asp Ala Thr Gln Ser Asn Gln Tyr 
        195                 200                 205             


Ile Ala Leu Gly Thr Ile Tyr Thr Asp Pro Asp Gly Thr Pro Gly Phe 
    210                 215                 220                 


Ser Thr Ser Arg Ser Gln Tyr Leu Asn Asp Gly Val Asn Arg Lys Ser 
225                 230                 235                 240 


Cys Ser Ile Ser Ala Val Pro Met Gly Cys Ala Leu Tyr Cys Phe Ile 
                245                 250                 255     


Ser Val Lys Glu Glu Val Asp Tyr Tyr Lys Gly Thr Val Pro Pro Ala 
            260                 265                 270         


Gln Thr Leu Ile Leu Phe Phe Phe Asn Gly Thr Val His Glu His Arg 
        275                 280                 285             


Ile Val Pro Ser Ser Met Asn Ser Glu Trp Val Met Leu Ser Pro Gly 
    290                 295                 300                 


Val Gly Ser Gly Val Phe Tyr Asn Asn Tyr Ile Ile Phe Pro Leu Tyr 
305                 310                 315                 320 


Gly Gly Met Thr Lys Asp Lys Ala Glu Lys Arg Gly Glu Leu Thr Arg 
                325                 330                 335     


Phe Phe Thr Pro Lys Asn Ser Arg Ser Leu Cys Lys Met Asn Asp Ser 
            340                 345                 350         


Val Phe Ser Asn Ala Ala Gln Ser Ala Tyr Tyr Pro Pro Tyr Phe Ser 
        355                 360                 365             


Ser Arg Trp Ile Arg Ser Gly Leu Leu Ala Cys Asn Trp Asn Gln Ile 
    370                 375                 380                 


Ile Thr Thr Asn Cys Glu Ile Leu Thr Phe Ser Asn Gln Val Met Met 
385                 390                 395                 400 


Met Gly Ala Glu Gly Arg Leu Ile Leu Ile Asn Asp Asp Leu Phe Tyr 
                405                 410                 415     


Tyr Gln Arg Ser Thr Ser Trp Trp Pro Arg Pro Leu Val Tyr Lys Leu 
            420                 425                 430         


Asp Ile Glu Leu Asn Tyr Pro Asp Ser His Ile Gln Arg Val Asp Gln 
        435                 440                 445             


Val Glu Val Thr Phe Pro Thr Arg Pro Gly Trp Gly Gly Cys Val Gly 
    450                 455                 460                 


Asn Asn Phe Cys Pro Met Ile Cys Val Ser Gly Val Tyr Gln Asp Val 
465                 470                 475                 480 


Trp Pro Val Thr Asn Pro Val Asn Thr Thr Asp Ser Arg Thr Leu Trp 
                485                 490                 495     


Val Gly Gly Thr Leu Leu Ser Asn Thr Thr Arg Glu Asn Pro Ala Ser 
            500                 505                 510         


Val Val Thr Ser Gly Gly Ser Ile Ser Gln Thr Val Ser Trp Phe Asn 
        515                 520                 525             


Gln Thr Val Pro Gly Ala Tyr Ser Thr Thr Thr Cys Phe Asn Asp Gln 
    530                 535                 540                 


Val Gln Gly Arg Ile Phe Cys Leu Ile Ile Phe Glu Val Gly Gly Gly 
545                 550                 555                 560 


Leu Leu Gly Glu Tyr Gln Ile Val Pro Phe Leu Lys Glu Leu Lys Tyr 
                565                 570                 575     


Gln Gly Ala Val His Ala 
            580         


<210>  420
<211>  538
<212>  PRT
<213>  Mumps orthorubulavirus

<400>  420

Met Lys Ala Phe Pro Val Ile Cys Leu Gly Phe Ala Ile Phe Ser Ser 
1               5                   10                  15      


Ser Ile Cys Val Asn Ile Asn Ile Leu Gln Gln Ile Gly Tyr Ile Lys 
            20                  25                  30          


Gln Gln Val Arg Gln Leu Ser Tyr Tyr Ser Gln Ser Ser Ser Ser Tyr 
        35                  40                  45              


Val Val Val Lys Leu Leu Pro Asn Ile Gln Pro Thr Asp Asn Ser Cys 
    50                  55                  60                  


Glu Phe Lys Ser Val Thr Gln Tyr Asn Lys Thr Leu Ser Asn Leu Leu 
65                  70                  75                  80  


Leu Pro Ile Ala Glu Asn Ile Asn Asn Ile Thr Ser Pro Ser Pro Gly 
                85                  90                  95      


Ser Arg Arg His Lys Arg Phe Ala Gly Ile Ala Ile Gly Ile Ala Ala 
            100                 105                 110         


Leu Gly Val Ala Thr Ala Ala Gln Val Thr Ala Ala Val Ser Leu Val 
        115                 120                 125             


Gln Ala Gln Thr Asn Ala Arg Ala Ile Ala Ala Met Lys Asn Ser Ile 
    130                 135                 140                 


Gln Ala Thr Asn Arg Ala Val Phe Glu Val Lys Glu Gly Thr Gln Gln 
145                 150                 155                 160 


Leu Ala Ile Ala Val Gln Ala Ile Gln Asp His Ile Asn Thr Ile Met 
                165                 170                 175     


Asn Thr Gln Leu Asn Asn Met Ser Cys Gln Ile Leu Asp Asn Gln Leu 
            180                 185                 190         


Ala Thr Ser Leu Gly Leu Tyr Leu Thr Glu Leu Thr Thr Val Phe Gln 
        195                 200                 205             


Pro Gln Leu Ile Asn Pro Ala Leu Ser Pro Ile Ser Ile Gln Ala Leu 
    210                 215                 220                 


Arg Ser Leu Leu Gly Ser Met Thr Pro Ala Val Val Gln Ala Thr Leu 
225                 230                 235                 240 


Ser Thr Ser Ile Ser Ala Ala Glu Ile Leu Ser Ala Gly Leu Met Glu 
                245                 250                 255     


Gly Gln Ile Val Ser Val Leu Leu Asp Glu Met Gln Met Ile Val Lys 
            260                 265                 270         


Ile Asn Val Pro Thr Ile Val Thr Gln Ser Asn Ala Leu Val Ile Asp 
        275                 280                 285             


Phe Tyr Ser Ile Ser Ser Phe Ile Asn Asn Gln Glu Ser Ile Ile Gln 
    290                 295                 300                 


Leu Pro Asp Arg Ile Leu Glu Ile Gly Asn Glu Gln Trp Arg Tyr Pro 
305                 310                 315                 320 


Ala Lys Asn Cys Lys Leu Thr Arg His His Ile Phe Cys Gln Tyr Asn 
                325                 330                 335     


Glu Ala Glu Arg Leu Ser Leu Glu Thr Lys Leu Cys Leu Ala Gly Asn 
            340                 345                 350         


Ile Ser Ala Cys Val Phe Ser Ser Ile Ala Gly Ser Tyr Met Arg Arg 
        355                 360                 365             


Phe Val Ala Leu Asp Gly Thr Ile Val Ala Asn Cys Arg Ser Leu Thr 
    370                 375                 380                 


Cys Leu Cys Lys Ser Pro Ser Tyr Pro Ile Tyr Gln Pro Asp His His 
385                 390                 395                 400 


Ala Val Thr Thr Ile Asp Leu Thr Ser Cys Gln Thr Leu Ser Leu Asp 
                405                 410                 415     


Gly Leu Asp Phe Ser Ile Val Ser Leu Ser Asn Ile Thr Tyr Ala Glu 
            420                 425                 430         


Asn Leu Thr Ile Ser Leu Ser Gln Thr Ile Asn Thr Gln Pro Ile Asp 
        435                 440                 445             


Ile Ser Thr Glu Leu Ser Lys Val Asn Ala Ser Leu Gln Asn Ala Val 
    450                 455                 460                 


Lys Tyr Ile Lys Glu Ser Asn His Gln Leu Gln Ser Val Ser Val Ser 
465                 470                 475                 480 


Ser Lys Ile Gly Ala Ile Ile Val Ala Ala Leu Val Leu Ser Ile Leu 
                485                 490                 495     


Ser Ile Ile Ile Ser Leu Leu Phe Cys Phe Trp Ala Tyr Ile Ala Thr 
            500                 505                 510         


Lys Glu Ile Arg Arg Ile Asn Phe Lys Thr Asn His Ile Asn Thr Ile 
        515                 520                 525             


Ser Ser Ser Val Asp Asp Leu Ile Arg Tyr 
    530                 535             


<210>  421
<211>  582
<212>  PRT
<213>  Mumps orthorubulavirus

<400>  421

Met Glu Pro Ser Lys Leu Phe Ile Met Ser Asp Asn Ala Thr Val Ala 
1               5                   10                  15      


Pro Gly Pro Val Val Asn Ala Ala Gly Lys Lys Thr Phe Arg Thr Cys 
            20                  25                  30          


Phe Arg Ile Leu Val Leu Ser Val Gln Ala Val Thr Leu Ile Leu Val 
        35                  40                  45              


Ile Val Thr Leu Gly Glu Leu Ile Arg Met Ile Asn Asp Gln Gly Leu 
    50                  55                  60                  


Ser Asn Gln Leu Ser Ser Ile Thr Asp Lys Ile Arg Glu Ser Ala Ala 
65                  70                  75                  80  


Val Ile Ala Ser Ala Val Gly Val Met Asn Gln Val Ile His Gly Val 
                85                  90                  95      


Thr Val Ser Leu Pro Leu Gln Ile Glu Gly Asn Gln Asn Gln Leu Leu 
            100                 105                 110         


Ser Thr Leu Ala Thr Ile Cys Thr Asn Arg Asn Gln Val Ser Asn Cys 
        115                 120                 125             


Ser Thr Asn Ile Pro Leu Val Asn Asp Leu Arg Phe Ile Asn Gly Ile 
    130                 135                 140                 


Asn Lys Phe Ile Ile Glu Asp Tyr Ala Thr His Asp Phe Ser Ile Gly 
145                 150                 155                 160 


Asn Pro Leu Asn Met Pro Ser Phe Ile Pro Thr Ala Thr Ser Pro Asn 
                165                 170                 175     


Gly Cys Thr Arg Ile Pro Ser Phe Ser Leu Gly Lys Thr His Trp Cys 
            180                 185                 190         


Tyr Thr His Asn Val Ile Asn Ala Asn Cys Lys Asp His Thr Ser Ser 
        195                 200                 205             


Asn Gln Tyr Val Ser Met Gly Ile Leu Val Gln Thr Ala Ser Gly Tyr 
    210                 215                 220                 


Pro Met Phe Lys Thr Leu Lys Ile Gln Tyr Leu Ser Asp Gly Leu Asn 
225                 230                 235                 240 


Arg Lys Ser Cys Ser Ile Ala Thr Val Pro Asp Gly Cys Ala Met Tyr 
                245                 250                 255     


Cys Tyr Val Ser Thr Gln Leu Glu Ala Asn Asp Tyr Ala Gly Ser Ser 
            260                 265                 270         


Pro Pro Thr Gln Lys Leu Thr Leu Leu Phe Tyr Asn Asp Thr Ile Thr 
        275                 280                 285             


Glu Arg Thr Ile Ser Pro Ser Gly Leu Glu Gly Asn Trp Ala Thr Leu 
    290                 295                 300                 


Val Pro Gly Val Gly Ser Gly Ile Tyr Phe Glu Asn Lys Leu Ile Phe 
305                 310                 315                 320 


Pro Ala Tyr Gly Gly Val Leu Pro Asn Ser Thr Leu Gly Val Lys Ser 
                325                 330                 335     


Ala Arg Glu Phe Phe Arg Pro Val Asn Pro Tyr Asn Pro Cys Ser Gly 
            340                 345                 350         


Pro Pro Gln Glu Leu Asp Gln Arg Ala Leu Arg Ser Tyr Phe Pro Arg 
        355                 360                 365             


Tyr Phe Ser Ser Arg Arg Val Gln Ser Ala Phe Leu Val Cys Ala Trp 
    370                 375                 380                 


Asn Gln Ile Leu Val Thr Asn Cys Glu Leu Val Val Pro Ser Asn Asn 
385                 390                 395                 400 


Gln Thr Leu Met Gly Ala Glu Gly Arg Val Leu Leu Ile Asn Asn Arg 
                405                 410                 415     


Leu Leu Tyr Tyr Gln Arg Ser Thr Ser Trp Trp Pro Tyr Glu Leu Leu 
            420                 425                 430         


Tyr Glu Ile Ser Phe Thr Phe Thr Asn Ser Gly Gln Ser Ser Val Asn 
        435                 440                 445             


Met Ser Trp Ile Pro Ile Tyr Ser Phe Thr Pro Pro Gly Ser Gly Asn 
    450                 455                 460                 


Cys Ser Gly Lys Asn Val Cys Pro Thr Val Cys Val Ser Gly Val Tyr 
465                 470                 475                 480 


Leu Asp Pro Trp Pro Leu Thr Pro Tyr Ser His Gln Ser Gly Ile Asn 
                485                 490                 495     


Arg Asn Phe Tyr Phe Thr Gly Ala Leu Leu Asn Ser Ser Thr Thr Arg 
            500                 505                 510         


Val Asn Pro Thr Leu Tyr Val Ser Ala Leu Asn Asn Leu Lys Val Leu 
        515                 520                 525             


Ala Pro Tyr Gly Thr Gln Gly Leu Phe Ala Ser Tyr Thr Thr Thr Thr 
    530                 535                 540                 


Cys Phe Gln Asp Thr Gly Asp Ala Ser Val Tyr Cys Val Tyr Ile Met 
545                 550                 555                 560 


Glu Leu Ala Ser Asn Ile Val Gly Glu Phe Gln Ile Leu Pro Val Leu 
                565                 570                 575     


Ala Arg Leu Thr Ile Thr 
            580         


<210>  422
<211>  576
<212>  PRT
<213>  Porcine orthorubulavirus

<400>  422

Met Ser Gln Leu Gly Thr Asp Gln Ile Met His Leu Ala Gln Pro Ala 
1               5                   10                  15      


Ile Ala Arg Arg Thr Trp Arg Leu Cys Phe Arg Ile Phe Ala Leu Phe 
            20                  25                  30          


Ile Leu Ile Ala Ile Val Ile Thr Gln Ile Phe Met Leu Thr Phe Asp 
        35                  40                  45              


His Thr Leu Leu Thr Thr Thr Gln Phe Leu Thr Ser Ile Gly Asn Leu 
    50                  55                  60                  


Gln Ser Thr Ile Thr Ser Trp Asn Pro Asp Val Gln Ala Met Leu Ser 
65                  70                  75                  80  


Ile Ser Asn Gln Leu Ile Tyr Thr Thr Ser Ile Thr Leu Pro Leu Lys 
                85                  90                  95      


Ile Ser Thr Thr Glu Met Ser Ile Leu Thr Ala Ile Arg Asp His Cys 
            100                 105                 110         


His Cys Pro Asp Cys Ser Ser Ala Cys Pro Thr Arg Gln Met Leu Leu 
        115                 120                 125             


Asn Asp Pro Arg Tyr Met Ser Gly Val Asn Gln Phe Ile Gly Ala Pro 
    130                 135                 140                 


Thr Glu Ser Ile Asn Ile Thr Phe Gly Pro Leu Leu Gly Ile Pro Ser 
145                 150                 155                 160 


Phe Ile Pro Thr Ser Thr Thr Thr Gln Gly Cys Thr Arg Ile Pro Ser 
                165                 170                 175     


Phe Ala Leu Gly Pro Ser His Trp Cys Tyr Thr His Asn Phe Ile Ile 
            180                 185                 190         


Ala Gly Cys Ala Asp Gly Gly His Ser Asn Gln Tyr Leu Ala Met Gly 
        195                 200                 205             


Thr Ile Gln Ser Ala Ser Asp Gly Ser Pro Leu Leu Ile Thr Ala Arg 
    210                 215                 220                 


Ser Tyr Tyr Leu Ser Asp Gly Val Asn Arg Lys Ser Cys Ser Ile Ala 
225                 230                 235                 240 


Val Val Pro Gly Gly Cys Ala Met Tyr Cys Tyr Val Ala Thr Arg Ser 
                245                 250                 255     


Glu Thr Asp Tyr Tyr Ala Gly Asn Ser Pro Pro Gln Gln Leu Leu Thr 
            260                 265                 270         


Leu Val Phe Ser Asn Asp Thr Ile Ile Glu Arg Thr Ile His Pro Thr 
        275                 280                 285             


Gly Leu Ala Asn Gly Trp Val Met Leu Val Pro Gly Val Gly Ser Gly 
    290                 295                 300                 


Thr Leu Tyr Asn Glu Tyr Leu Leu Phe Pro Ala Tyr Gly Gly Met Gln 
305                 310                 315                 320 


Gln Ile Leu Ala Asn Gln Ser Gly Glu Ile Asn Gln Phe Phe Thr Pro 
                325                 330                 335     


Tyr Asn Ala Thr Val Arg Cys Ala Met Ala Gln Pro Gln Phe Ser Gln 
            340                 345                 350         


Arg Ala Ala Ala Ser Tyr Tyr Pro Arg Tyr Phe Ser Asn Arg Trp Ile 
        355                 360                 365             


Arg Ser Ala Ile Val Ala Cys Pro Tyr Arg Ala Ile Tyr Gln Thr Gln 
    370                 375                 380                 


Cys Thr Leu Ile Pro Leu Pro Asn Arg Met Val Met Met Gly Ser Glu 
385                 390                 395                 400 


Gly Arg Ile Phe Thr Leu Gly Asp Arg Leu Phe Tyr Tyr Gln Arg Ser 
                405                 410                 415     


Ser Ser Trp Trp Pro Tyr Pro Leu Leu Tyr Gln Val Gly Leu Asn Phe 
            420                 425                 430         


Leu Thr Thr Pro Pro Ser Val Ser Ser Met Thr Gln Val Pro Leu Glu 
        435                 440                 445             


His Leu Ala Arg Pro Gly Lys Gly Gly Cys Pro Gly Asn Ser His Cys 
    450                 455                 460                 


Pro Ala Thr Cys Val Thr Gly Val Tyr Ala Asp Val Trp Pro Leu Thr 
465                 470                 475                 480 


Asp Pro Arg Ser Gly Val Gly Gly Thr Ser Leu Val Ala Ala Gly Gly 
                485                 490                 495     


Leu Asp Ser Thr Ser Glu Arg Met Ala Pro Val Asn Tyr Leu Ala Ile 
            500                 505                 510         


Gly Glu Ser Leu Leu Ser Lys Thr Tyr Leu Leu Ser Lys Thr Gln Pro 
        515                 520                 525             


Ala Ala Tyr Thr Thr Thr Thr Cys Phe Arg Asp Thr Asp Thr Gly Lys 
    530                 535                 540                 


Ile Tyr Cys Ile Thr Ile Ala Glu Leu Gly Lys Val Leu Leu Gly Glu 
545                 550                 555                 560 


Phe Gln Ile Val Pro Phe Leu Arg Glu Ile Lys Ile Gln Ser Arg Tyr 
                565                 570                 575     


<210>  423
<211>  541
<212>  PRT
<213>  Porcine orthorubulavirus

<400>  423

Met Pro Gln Gln Gln Val Ala His Thr Cys Val Met Leu Trp Gly Ile 
1               5                   10                  15      


Ile Ser Thr Val Ser Gly Ile Asn Thr Glu Ala Leu Ser Gln Tyr Gly 
            20                  25                  30          


Val Val Val Thr Asn Val Arg Gln Leu Thr Tyr Tyr Thr Gln Ala Gly 
        35                  40                  45              


Ser Thr Tyr Leu Ala Val Arg Leu Leu Pro Ser Leu Ala Ser Pro Asp 
    50                  55                  60                  


Gln Ser Cys Ala Leu His Ser Ile Ile Asn Tyr Asn Ala Thr Leu Gln 
65                  70                  75                  80  


Ala Ile Leu Ser Pro Ile Ala Glu Asn Leu Asn Leu Ile Ser Thr Ala 
                85                  90                  95      


Leu Arg Glu Gln His Arg Lys Lys Arg Phe Ala Gly Val Ala Ile Gly 
            100                 105                 110         


Leu Thr Ala Leu Gly Val Ala Thr Ala Ala Gln Ala Thr Ala Ala Val 
        115                 120                 125             


Ala Leu Val Arg Ala Asn Lys Asn Ala Glu Lys Val Glu Gln Leu Ser 
    130                 135                 140                 


Gln Ala Leu Gly Glu Thr Asn Ala Ala Ile Ser Asp Leu Ile Asp Ala 
145                 150                 155                 160 


Thr Lys Asn Leu Gly Phe Ala Val Gln Ala Ile Gln Asn Gln Ile Asn 
                165                 170                 175     


Thr Ala Ile Leu Pro Gln Ile His Asn Leu Ser Cys Gln Val Ile Asp 
            180                 185                 190         


Ala Gln Leu Gly Asn Ile Leu Ser Leu Tyr Leu Thr Glu Leu Thr Thr 
        195                 200                 205             


Val Phe Gln Pro Gln Leu Thr Asn Pro Ala Leu Ser Pro Leu Thr Ile 
    210                 215                 220                 


Gln Ala Leu Arg Ala Val Leu Gly Thr Thr Leu Pro Ala Leu Leu Ser 
225                 230                 235                 240 


Glu Lys Leu Lys Ser Asn Ile Pro Leu Gly Asp Leu Met Ser Ser Gly 
                245                 250                 255     


Leu Leu Lys Gly Gln Leu Val Gly Leu Asn Leu Gln Asn Met Leu Met 
            260                 265                 270         


Ile Ile Glu Leu Tyr Ile Pro Thr Leu Ser Thr His Ser Thr Ala Lys 
        275                 280                 285             


Val Leu Asp Leu Val Thr Ile Ser Ser His Val Asn Gly Arg Glu Val 
    290                 295                 300                 


Glu Ile Gln Val Pro Asn Arg Val Leu Glu Leu Gly Ser Glu Val Leu 
305                 310                 315                 320 


Gly Tyr Gly Gly Ser Glu Cys Ala Leu Thr Met Ser His Ile Leu Cys 
                325                 330                 335     


Pro Phe Asn Asp Ala Arg Val Leu Ser Thr Asp Met Lys Tyr Cys Leu 
            340                 345                 350         


Gln Gly Asn Ile Thr His Cys Ile Phe Ser Pro Val Val Gly Ser Phe 
        355                 360                 365             


Leu Arg Arg Phe Ala Leu Val Asn Gly Val Val Ile Ala Asn Cys Ala 
    370                 375                 380                 


Asp Met Ser Cys Val Cys Phe Asp Pro Gln Glu Ile Ile Tyr Gln Asn 
385                 390                 395                 400 


Phe Gln Glu Pro Thr Thr Val Ile Asp Ile Lys Lys Cys Gly Lys Val 
                405                 410                 415     


Gln Leu Asp Thr Leu Thr Phe Thr Ile Ser Thr Phe Ala Asn Arg Thr 
            420                 425                 430         


Tyr Gly Pro Pro Ala Tyr Val Pro Pro Asp Asn Ile Ile Gln Ser Glu 
        435                 440                 445             


Pro Leu Asp Ile Ser Gly Asn Leu Ile Ala Val Asn Asn Ser Leu Ser 
    450                 455                 460                 


Ser Ala Leu Asn His Leu Ala Thr Ser Glu Ile Leu Arg Asn Glu Gln 
465                 470                 475                 480 


Ile Trp Thr Ser Ser Leu Gly Ile Ser Thr Ile Val Ala Leu Val Ile 
                485                 490                 495     


Ile Gly Ile Leu Ile Ile Cys Leu Val Val Thr Trp Ala Ala Leu Trp 
            500                 505                 510         


Ala Leu Leu Lys Glu Val Arg Gly Leu Asn Ser Ala Val Asn Ser Gln 
        515                 520                 525             


Leu Ser Ser Tyr Val Met Gly Asp Lys Phe Ile Arg Tyr 
    530                 535                 540     


<210>  424
<211>  561
<212>  PRT
<213>  Simian orthorubulavirus

<400>  424

Met Arg Leu Thr Pro Tyr Pro Ile Ala Leu Thr Thr Leu Met Ile Ala 
1               5                   10                  15      


Leu Thr Thr Leu Pro Glu Thr Gly Leu Gly Ile Ala Arg Asp Ala Leu 
            20                  25                  30          


Ser Gln Val Gly Val Ile Gln Ser Lys Ala Arg Ser Leu Met Tyr Tyr 
        35                  40                  45              


Ser Asp Gly Ser Ser Ser Phe Ile Val Val Lys Leu Leu Pro Thr Leu 
    50                  55                  60                  


Pro Thr Pro Ser Gly Asn Cys Asn Leu Thr Ser Ile Thr Ala Tyr Asn 
65                  70                  75                  80  


Thr Thr Leu Phe Lys Leu Leu Thr Pro Leu Met Glu Asn Leu Asp Thr 
                85                  90                  95      


Ile Val Ser Ala Asn Gln Ala Gly Ser Arg Arg Lys Arg Phe Ala Gly 
            100                 105                 110         


Val Val Val Gly Leu Ala Ala Leu Gly Val Ala Thr Ala Ala Gln Val 
        115                 120                 125             


Thr Ala Ala Val Ala Val Val Lys Ala Asn Ala Asn Ala Ala Ala Ile 
    130                 135                 140                 


Asn Lys Leu Ala Ala Ser Ile Gln Ser Thr Asn Ala Ala Ile Ser Asp 
145                 150                 155                 160 


Val Ile Ser Ser Thr Arg Thr Leu Ala Thr Ala Ile Gln Ala Val Gln 
                165                 170                 175     


Asp His Val Asn Gly Val Leu Ala Ser Gly Leu Thr Glu Ala Asn Cys 
            180                 185                 190         


Arg Ser Gln Asp Ala Leu Ile Gly Ser Ile Leu Asn Leu Tyr Leu Thr 
        195                 200                 205             


Glu Leu Thr Thr Ile Phe His Asn Gln Ile Val Asn Pro Ala Leu Thr 
    210                 215                 220                 


Pro Leu Ser Ile Gln Ala Leu Arg Ile Ile Leu Gly Ser Thr Leu Pro 
225                 230                 235                 240 


Leu Ile Val Glu Ser Arg Trp Asn Thr Asn Leu Asn Thr Ala Glu Leu 
                245                 250                 255     


Leu Ser Ser Gly Leu Leu Thr Gly Gln Ile Ile Ser Ile Ser Pro Ser 
            260                 265                 270         


Tyr Met Gln Met Val Ile Gln Ile Thr Val Pro Thr Phe Val Met Gln 
        275                 280                 285             


Pro Gly Ala Lys Ile Ile Asp Leu Val Thr Ile Thr Ala Asn Arg Met 
    290                 295                 300                 


Glu Glu Glu Val Leu Ile Gln Val Pro Pro Arg Ile Leu Glu Tyr Ala 
305                 310                 315                 320 


Asn Glu Ile Gln Ala Tyr Thr Ala Asp Asp Cys Val Val Thr Pro His 
                325                 330                 335     


Ala Val Phe Cys Lys Tyr Asn Asp Gly Ser Pro Ile Ser Asp Ser Leu 
            340                 345                 350         


Tyr Gln Cys Leu Lys Gly Asn Leu Thr Ser Cys Val Phe Thr Pro Val 
        355                 360                 365             


Val Gly Asn Tyr Leu Lys Arg Phe Ala Phe Ala Asn Gly Val Met Tyr 
    370                 375                 380                 


Val Asn Cys Lys Ala Leu Leu Cys Arg Cys Ala Asp Pro Pro Met Val 
385                 390                 395                 400 


Ile Thr Gln Asp Asp Leu Ala Gly Ile Thr Val Ile Asp Ile Thr Val 
                405                 410                 415     


Cys Arg Glu Val Met Leu Asp Thr Leu Ala Phe Lys Ile Thr Ser Leu 
            420                 425                 430         


Asn Asn Val Thr Tyr Gly Ala Asn Phe Ser Met Leu Ala Ala Ala Ile 
        435                 440                 445             


Lys Asp Leu Ser Pro Leu Asp Leu Ser Ala Gln Leu Ala Gln Val Asn 
    450                 455                 460                 


Lys Ser Leu Ala Ser Ala Glu Glu Lys Ile Ala Gln Ser Ser Ser Leu 
465                 470                 475                 480 


Ala Ala Gln Ala Val Ser Gln Glu Ala Thr Ile Thr Val Gly Ser Val 
                485                 490                 495     


Ala Met Leu Ile Ala Val Leu Ala Leu Ile Ala Gly Cys Thr Gly Ile 
            500                 505                 510         


Met Ile Ala Val Gln Met Ser Arg Arg Leu Glu Val Leu Arg His Leu 
        515                 520                 525             


Thr Asp Gln Ser Ile Ile Ser Asn His His Tyr Ala Glu Leu Asn Pro 
    530                 535                 540                 


Pro Pro Tyr Asn His Ser Tyr Glu Ser Leu His Pro Ile Pro Gln Ser 
545                 550                 555                 560 


His 
    


<210>  425
<211>  568
<212>  PRT
<213>  Simian orthorubulavirus

<400>  425

Met Ser Gly Ala Glu Gly Asn Thr Asn Lys Arg Thr Phe Arg Ala Val 
1               5                   10                  15      


Phe Arg Thr Leu Ile Ile Leu Ile Thr Leu Thr Ile Leu Ala Leu Ser 
            20                  25                  30          


Ala Ala Ile Leu Tyr Glu Val Thr His Thr Ser Asn Gly Ser Glu Ser 
        35                  40                  45              


Asn Asn Gln Val Phe Asp Pro Thr Asp Thr Leu Asn Ala Ile Thr Gly 
    50                  55                  60                  


Asn Ile Lys Ser Met Ile Ala Leu Leu Asn Gln Ile Leu Tyr Asn Ala 
65                  70                  75                  80  


Ala Ile Ala Leu Pro Leu Lys Ile Asp Ser Thr Glu Ser Val Leu Leu 
                85                  90                  95      


Ala Ala Ile Lys Asp Leu Gln Phe Ser Asn Pro Ala Ser Gln Asn Cys 
            100                 105                 110         


Ser Ser Gly Gly Asn Leu Leu Asn Asp Ala Leu Tyr Ile Asn Gly Ile 
        115                 120                 125             


Asn Gln Tyr Leu Leu Ser Asn Ser Phe Ala Gly Thr Val Gly Leu Gly 
    130                 135                 140                 


Pro Leu Leu Asn Ile Pro Ser Phe Ile Pro Ser Ala Thr Ala Pro Gly 
145                 150                 155                 160 


Gly Cys Thr Arg Ile Pro Ser Phe Ser Leu Thr Lys Thr His Trp Cys 
                165                 170                 175     


Tyr Ser His Asn Val Ile Leu Ala Gly Cys Ala Asp Ser Lys Ala Ser 
            180                 185                 190         


Asn Gln Tyr Leu Ala Met Gly Ile Val Glu Gln Ser Ser Ala Asp Phe 
        195                 200                 205             


Pro Phe Phe Arg Thr Met Arg Thr Leu Tyr Leu Ser Asp Gly Ile Asn 
    210                 215                 220                 


Arg Lys Ser Cys Ser Ile Val Ala Ile Pro Gly Gly Cys Ala Leu Tyr 
225                 230                 235                 240 


Cys Tyr Val Ala Thr Lys Thr Glu Gln Glu Asp Tyr Ala Ala Thr Thr 
                245                 250                 255     


Pro Ser Glu Leu Arg Leu Thr Phe Tyr Tyr Tyr Asn Glu Thr Leu Val 
            260                 265                 270         


Glu Arg Thr Leu Thr Ile Pro Asn Val Thr Gly Asn Trp Ala Thr Leu 
        275                 280                 285             


Asn Pro Ala Val Gly Ser Gly Val Tyr His Leu Gly Tyr Leu Ala Phe 
    290                 295                 300                 


Pro Val Tyr Gly Gly Leu Ile Gln Asn Ser Ala Ala Trp Asn Ser Gln 
305                 310                 315                 320 


Phe Gly Ser Tyr Phe Leu Pro Gln Asn Pro Ala Val Gln Cys Ser Gly 
                325                 330                 335     


Ser Ala Glu Gln Gln Ile Asn Thr Ala Lys Gly Ser Tyr Val Val Asn 
            340                 345                 350         


Trp Phe Ser Gly Arg Leu Ile Gln Ser Ala Val Leu Val Cys Pro Leu 
        355                 360                 365             


Ser Asp Gln Leu Thr Asp Gln Cys Arg Val Val Leu Phe Asn Asn Ser 
    370                 375                 380                 


Glu Thr Met Met Gly Ala Glu Gly Arg Leu Tyr Thr Ile Gly Gly Asp 
385                 390                 395                 400 


Leu Tyr Tyr Tyr Gln Arg Ser Ser Ser Trp Trp Thr Ala Ser Leu Leu 
                405                 410                 415     


Tyr Lys Ile Asn Thr Asp Phe Ser Gln Gly Leu Pro Pro Leu Ile Glu 
            420                 425                 430         


Ala Gln Trp Val Pro Thr Tyr Leu Val Pro Arg Pro Gly Ala Gln Pro 
        435                 440                 445             


Cys Ser Ala Gly Asn Phe Cys Pro Ala Asn Cys Ile Thr Gly Val Tyr 
    450                 455                 460                 


Ala Asp Val Trp Pro Met Asn Asn Pro Phe Pro Ala Gly Ser Ser Gly 
465                 470                 475                 480 


Val Asn Pro Asn Tyr Leu Phe Gly Gly Ala Phe Leu Trp Ala Asp Val 
                485                 490                 495     


Ala Arg Val Asn Pro Thr Phe Tyr Met Ala Ser Ala Thr Gln Tyr Lys 
            500                 505                 510         


Asn Thr Thr Gly Phe Pro Asn Ser Asn Gln Lys Ala Ala Tyr Thr Ser 
        515                 520                 525             


Thr Thr Cys Phe Gln Asn Thr Gly Ser Lys Lys Ile Tyr Cys Leu Phe 
    530                 535                 540                 


Ile Ile Glu Met Gly Ser Ser Leu Met Gly Glu Phe Gln Ile Val Pro 
545                 550                 555                 560 


Phe Leu Arg Glu Val Ile Ile Thr 
                565             


<210>  426
<211>  533
<212>  PRT
<213>  Achimota pararubulavirus 1

<400>  426

Met Trp Ile Met Ile Ile Leu Ser Leu Phe Gln Ile Ile Pro Gly Val 
1               5                   10                  15      


Thr Pro Ile Asn Ser Lys Val Leu Thr Gln Leu Gly Val Ile Thr Lys 
            20                  25                  30          


His Thr Arg Gln Leu Lys Phe Tyr Ser His Ser Thr Pro Ser Tyr Leu 
        35                  40                  45              


Val Val Lys Leu Val Pro Thr Ile Asn Thr Glu Ser Thr Val Cys Asn 
    50                  55                  60                  


Phe Thr Ser Leu Ser Arg Tyr Lys Asp Ser Val Arg Glu Leu Ile Thr 
65                  70                  75                  80  


Pro Leu Ala Lys Asn Ile Asp Asn Leu Asn Ser Ile Leu Thr Ile Pro 
                85                  90                  95      


Lys Arg Arg Lys Arg Met Ala Gly Val Val Ile Gly Leu Ala Ala Leu 
            100                 105                 110         


Gly Val Ala Ala Ala Ala Gln Ala Thr Ala Ala Val Ala Leu Ile Glu 
        115                 120                 125             


Ala Lys Lys Asn Thr Glu Gln Ile Gln Ala Leu Ser Glu Ser Ile Gln 
    130                 135                 140                 


Asn Thr Asn Lys Ala Val Ser Ser Ile Glu Lys Gly Leu Ser Ser Ala 
145                 150                 155                 160 


Ala Ile Ala Val Gln Ala Ile Gln Asn Gln Ile Asn Asn Val Ile Asn 
                165                 170                 175     


Pro Ala Leu Thr Ala Leu Asp Cys Gly Val Thr Asp Ala Gln Leu Gly 
            180                 185                 190         


Asn Ile Leu Asn Leu Tyr Leu Ile Lys Thr Leu Thr Val Phe Gln Lys 
        195                 200                 205             


Gln Ile Thr Asn Pro Ala Leu Gln Pro Leu Ser Ile Gln Ala Leu Asn 
    210                 215                 220                 


Ile Ile Met Gln Glu Thr Ser Ser Val Leu Arg Asn Phe Thr Lys Thr 
225                 230                 235                 240 


Asp Glu Ile Glu His Thr Asp Leu Leu Thr Ser Gly Leu Ile Thr Gly 
                245                 250                 255     


Gln Val Val Gly Val Asn Leu Thr Asn Leu Gln Leu Ile Ile Ala Ala 
            260                 265                 270         


Phe Ile Pro Ser Ile Ala Pro Leu Asn Gln Ala Tyr Ile Leu Asp Phe 
        275                 280                 285             


Ile Arg Ile Thr Val Asn Ile Asn Asn Ser Glu Ser Met Ile Gln Ile 
    290                 295                 300                 


Pro Glu Arg Ile Met Glu His Gly Ile Ser Leu Tyr Gln Phe Gly Gly 
305                 310                 315                 320 


Asp Gln Cys Thr Phe Ser Asp Trp Ser Ala Tyr Cys Pro Tyr Ser Asp 
                325                 330                 335     


Ala Thr Leu Met Ala Pro Gly Leu Gln Asn Cys Phe Arg Gly Gln Ala 
            340                 345                 350         


Ala Asp Cys Val Phe Ser Thr Val Met Gly Ser Phe Pro Asn Arg Phe 
        355                 360                 365             


Val Ser Val Gln Gly Val Phe Tyr Val Asn Cys Lys Phe Ile Arg Cys 
    370                 375                 380                 


Ala Cys Thr Gln Pro Gln Arg Leu Ile Thr Gln Asp Asp Ser Leu Ser 
385                 390                 395                 400 


Leu Thr Gln Ile Asp Ala Lys Thr Cys Arg Met Leu Thr Leu Gly Phe 
                405                 410                 415     


Val Gln Phe Ser Ile Asn Glu Tyr Ala Asn Val Thr Tyr Ser Phe Lys 
            420                 425                 430         


Asn Asn Val Thr Ala Gly Gln Leu Ile Met Thr Asn Pro Ile Asp Leu 
        435                 440                 445             


Ser Thr Glu Ile Lys Gln Met Asn Asp Ser Val Asp Glu Ala Ala Arg 
    450                 455                 460                 


Tyr Ile Glu Lys Ser Asn Ala Ala Leu Asn Lys Leu Met Tyr Gly Gly 
465                 470                 475                 480 


Arg Ser Asp Ile Val Thr Thr Val Leu Leu Val Gly Phe Ile Leu Leu 
                485                 490                 495     


Val Val Tyr Val Ile Phe Val Thr Tyr Ile Leu Lys Ile Leu Met Lys 
            500                 505                 510         


Glu Val Ala Arg Leu Arg Asn Ser Asn His Pro Asp Leu Ile Lys Pro 
        515                 520                 525             


Tyr Asn Tyr Pro Met 
    530             


<210>  427
<211>  595
<212>  PRT
<213>  Achimota pararubulavirus 1

<400>  427

Met Ala Thr Asn Leu Ser Thr Ile Thr Asn Gly Lys Phe Ser Gln Asn 
1               5                   10                  15      


Ser Asp Glu Gly Ser Leu Thr Glu Leu Pro Phe Phe Glu His Asn Arg 
            20                  25                  30          


Lys Val Ala Thr Thr Lys Arg Thr Cys Arg Phe Val Phe Arg Ser Val 
        35                  40                  45              


Ile Thr Leu Cys Asn Leu Thr Ile Leu Ile Val Thr Val Val Val Leu 
    50                  55                  60                  


Phe Gln Gln Ala Gly Phe Ile Lys Arg Thr Glu Ser Asn Gln Val Cys 
65                  70                  75                  80  


Glu Thr Leu Gln Asn Asp Met His Gly Val Val Thr Met Ser Lys Gly 
                85                  90                  95      


Val Ile Thr Thr Leu Asn Asn Leu Ile Glu Ile Thr Ser Val Asn Leu 
            100                 105                 110         


Pro Phe Gln Met Lys Gln Phe Gly Gln Gly Ile Val Thr Gln Val Thr 
        115                 120                 125             


Gln Met Val Arg Gln Cys Asn Ala Val Cys Lys Gly Pro Thr Ile Gly 
    130                 135                 140                 


Pro Asp Ile Gln Asn Ile Val Tyr Pro Ala Ser Tyr Glu Ser Met Ile 
145                 150                 155                 160 


Lys His Pro Val Asn Asn Ser Asn Ile Leu Leu Ser Glu Ile Arg Gln 
                165                 170                 175     


Pro Leu Asn Phe Val Pro Asn Thr Gly Lys Leu Asn Gly Cys Thr Arg 
            180                 185                 190         


Thr Pro Ser Phe Ser Val Tyr Asn Gly Phe Trp Cys Tyr Thr His Ala 
        195                 200                 205             


Glu Ser Asp Trp Asn Cys Asn Gly Ser Ser Pro Tyr Met Gln Val Phe 
    210                 215                 220                 


Arg Val Gly Val Val Thr Ser Asp Tyr Asp Tyr Asn Val Ile His Lys 
225                 230                 235                 240 


Thr Leu His Thr Lys Thr Ser Arg Leu Ala Asn Val Thr Tyr Gln Cys 
                245                 250                 255     


Ser Thr Ile Ser Thr Gly Tyr Glu Cys Tyr Phe Leu Cys Ser Thr Pro 
            260                 265                 270         


Asn Val Asp Glu Ile Thr Asp Tyr Lys Thr Pro Gly Ile Glu Ser Leu 
        275                 280                 285             


Gln Ile Tyr Lys Ile Asp Asn Arg Gly Thr Phe Ala Lys Phe Pro Ile 
    290                 295                 300                 


Thr Asp Gln Leu Asn Lys Glu Leu Leu Thr Ala Leu Tyr Pro Gly Pro 
305                 310                 315                 320 


Gly Asn Gly Val Leu Tyr Gln Gly Arg Leu Leu Phe Pro Met His Gly 
                325                 330                 335     


Gly Met Gln Ser Ser Glu Leu Asn Lys Val Asn Leu Asn Asn Thr Val 
            340                 345                 350         


Leu Ser Gln Phe Asn Asp Asn Lys Gly Cys Asn Ala Thr Glu Ile Lys 
        355                 360                 365             


Leu Glu Ser Glu Phe Pro Gly Thr Phe Thr Ser Pro Tyr Tyr Ser Asn 
    370                 375                 380                 


Gln Val Met Leu Asn Tyr Ile Leu Ile Cys Glu Met Ile Glu Asn Leu 
385                 390                 395                 400 


Pro Gly Asn Cys Asp Leu Gln Ile Val Ala Pro Lys Asn Met Ser Met 
                405                 410                 415     


Gly Ser Glu Ser Gln Leu Tyr Ser Ile Asn Asn Lys Leu Tyr Leu Tyr 
            420                 425                 430         


Gln Arg Ser Ser Ser Arg Trp Pro Tyr Pro Leu Ile Tyr Glu Val Gly 
        435                 440                 445             


Thr Arg Leu Thr Asn Arg Gln Phe Arg Leu Arg Ala Ile Asn Arg Phe 
    450                 455                 460                 


Leu Ile Lys Ser Thr Thr Arg Pro Gly Ser Glu Gly Cys Asn Ile Tyr 
465                 470                 475                 480 


Arg Val Cys Pro Lys Val Cys Val Thr Gly Val Tyr Gln Ala Pro Trp 
                485                 490                 495     


Ile Leu His Val Ser Lys Ala Gly Ser Gln Ser Ile Ala Lys Val Leu 
            500                 505                 510         


Tyr Ala Val Ala Trp Ser Lys Asp His Met Ser Arg Lys Gly Pro Leu 
        515                 520                 525             


Phe Ser Ile Cys Asp Asn Asp Thr Cys Phe Leu Thr Lys Ser Leu Ala 
    530                 535                 540                 


Ser Glu His Val His Ser Gly Tyr Ser Ile Thr Arg Cys Tyr Leu Glu 
545                 550                 555                 560 


Asn Ser Glu Arg His Ile Ile Cys Val Val Ile Met Glu Leu Asp Ala 
                565                 570                 575     


Ser Pro Trp Ala Glu Met Arg Ile Gln Ser Val Ile Tyr Asn Ile Thr 
            580                 585                 590         


Leu Pro Ser 
        595 


<210>  428
<211>  531
<212>  PRT
<213>  Achimota pararubulavirus 2

<400>  428

Met Leu Asn Ser Phe Tyr Gln Ile Ile Cys Leu Ala Val Cys Leu Thr 
1               5                   10                  15      


Thr Tyr Thr Val Ile Ser Ile Asp Gln His Asn Leu Leu Lys Ala Gly 
            20                  25                  30          


Val Ile Val Lys Ser Ile Lys Gly Leu Asn Phe Tyr Ser Arg Gly Gln 
        35                  40                  45              


Ala Asn Tyr Ile Ile Val Lys Leu Ile Pro Asn Val Asn Val Thr Asp 
    50                  55                  60                  


Thr Asp Cys Asp Ile Gly Ser Ile Lys Arg Tyr Asn Glu Thr Val Tyr 
65                  70                  75                  80  


Ser Leu Ile Lys Pro Leu Ala Asp Asn Ile Asp Tyr Leu Arg Thr Gln 
                85                  90                  95      


Phe Ala Pro Thr Lys Arg Lys Lys Arg Phe Ala Gly Val Ala Ile Gly 
            100                 105                 110         


Leu Thr Ala Leu Gly Val Ala Thr Ala Ala Gln Val Thr Ala Ala Val 
        115                 120                 125             


Ala Leu Val Lys Ala Gln Glu Asn Ala Arg Lys Leu Asp Ala Leu Ala 
    130                 135                 140                 


Asp Ser Ile Gln Ala Thr Asn Glu Ala Val Gln Asp Leu Ser Thr Gly 
145                 150                 155                 160 


Leu Gln Ala Gly Ala Ile Ala Ile Gln Ala Ile Gln Ser Glu Ile Asn 
                165                 170                 175     


His Val Ile Asn Pro Ala Leu Glu Arg Leu Ser Cys Glu Ile Ile Asp 
            180                 185                 190         


Thr Arg Val Ala Ser Ile Leu Asn Leu Tyr Leu Ile Arg Leu Thr Thr 
        195                 200                 205             


Val Phe His Arg Gln Leu Val Asn Pro Ala Leu Thr Pro Leu Ser Ile 
    210                 215                 220                 


Gln Ala Leu Asn His Leu Leu Gln Gly Glu Thr Glu Gly Leu Val Lys 
225                 230                 235                 240 


Asn Glu Ser Lys Met Thr Asp Ser Lys Ile Asp Leu Leu Met Ser Gly 
                245                 250                 255     


Leu Ile Thr Gly Gln Val Val Gly Val Asn Ile Lys His Met Gln Leu 
            260                 265                 270         


Met Ile Ala Val Phe Val Pro Thr Thr Ala Gln Leu Pro Asn Ala Tyr 
        275                 280                 285             


Val Ile Asn Leu Leu Thr Ile Thr Ala Asn Ile Asn Asn Ser Glu Val 
    290                 295                 300                 


Leu Val Gln Leu Pro Asn Gln Ile Leu Glu Arg Ser Gly Ile Ile Tyr 
305                 310                 315                 320 


Gln Phe Arg Gly Lys Asp Cys Val Ser Ser Pro Asn His Met Tyr Cys 
                325                 330                 335     


Pro Tyr Ser Asp Ala Ser Ile Leu Ser Pro Glu Leu Gln Leu Cys Leu 
            340                 345                 350         


Gln Gly Arg Leu Glu Met Cys Leu Phe Thr Gln Val Val Gly Ser Phe 
        355                 360                 365             


Pro Thr Arg Phe Ala Ser Asp Lys Gly Ile Val Tyr Ala Asn Cys Arg 
    370                 375                 380                 


His Leu Gln Cys Ala Cys Ser Glu Pro Glu Gly Ile Ile Tyr Gln Asp 
385                 390                 395                 400 


Asp Thr Ser Ala Ile Thr Gln Ile Asp Ala Ser Lys Cys Ser Thr Leu 
                405                 410                 415     


Lys Leu Asp Met Leu Thr Phe Lys Leu Ser Thr Tyr Ala Asn Lys Thr 
            420                 425                 430         


Phe Asp Ala Ser Phe Ser Val Gly Lys Asp Gln Met Leu Val Thr Asn 
        435                 440                 445             


Leu Leu Asp Leu Ser Ala Glu Leu Lys Thr Met Asn Ala Ser Val Ala 
    450                 455                 460                 


His Ala Asn Lys Leu Ile Asp Lys Ser Asn Leu Leu Ile Gln Ser Asn 
465                 470                 475                 480 


Ala Leu Ile Gly His Ser Asn Thr Ile Phe Ile Val Val Ile Val Ile 
                485                 490                 495     


Leu Ala Val Met Val Leu Tyr Leu Ile Ile Val Thr Tyr Ile Ile Lys 
            500                 505                 510         


Val Ile Met Val Glu Val Ser Arg Leu Lys Arg Met Asn Ile Tyr Ser 
        515                 520                 525             


Ile Asp Lys 
    530     


<210>  429
<211>  583
<212>  PRT
<213>  Achimota pararubulavirus 2

<400>  429

Met Asp Asn Ser Met Ser Ile Ser Thr Ile Ser Leu Asp Ala Gln Pro 
1               5                   10                  15      


Arg Ile Trp Ser Arg His Glu Ser Arg Arg Thr Trp Arg Asn Ile Phe 
            20                  25                  30          


Arg Ile Thr Ser Leu Val Leu Leu Gly Val Thr Val Ile Ile Cys Ile 
        35                  40                  45              


Trp Leu Cys Cys Glu Val Ala Arg Glu Ser Glu Leu Glu Leu Leu Ala 
    50                  55                  60                  


Ser Pro Leu Gly Ala Leu Ile Met Ala Ile Asn Thr Ile Lys Ser Ser 
65                  70                  75                  80  


Val Val Lys Met Thr Thr Glu Leu Asn Gln Val Thr Phe Thr Thr Ser 
                85                  90                  95      


Ile Ile Leu Pro Asn Lys Val Asp Gln Phe Gly Gln Asn Val Val Ser 
            100                 105                 110         


Gln Val Ala Gln Leu Val Lys Gln Cys Asn Ala Val Cys Arg Gly His 
        115                 120                 125             


Gln Asp Thr Pro Glu Leu Glu Gln Phe Ile Asn Gln Lys Asn Pro Thr 
    130                 135                 140                 


Trp Ile Leu Gln Pro Asn Tyr Thr Thr Lys Leu Thr Asn Leu His Glu 
145                 150                 155                 160 


Ile Asp Ser Ile Ile Pro Leu Val Asp Tyr Pro Gly Phe Ser Lys Ser 
                165                 170                 175     


Cys Thr Arg Phe Pro Ser Phe Ser Glu Gly Ser Lys Phe Trp Cys Phe 
            180                 185                 190         


Thr Tyr Ala Val Val Lys Glu Pro Cys Ser Asp Ile Ser Ser Ser Ile 
        195                 200                 205             


Gln Val Val Lys Tyr Gly Ala Ile Lys Ala Asn His Ser Asp Gly Asn 
    210                 215                 220                 


Pro Tyr Leu Val Leu Gly Thr Lys Val Leu Asp Asp Gly Lys Phe Arg 
225                 230                 235                 240 


Arg Gly Cys Ser Ile Thr Ser Ser Leu Tyr Gly Cys Tyr Leu Leu Cys 
                245                 250                 255     


Ser Thr Ala Asn Val Ser Glu Val Asn Asp Tyr Ala His Thr Pro Ala 
            260                 265                 270         


Tyr Pro Leu Thr Leu Glu Leu Ile Ser Lys Asp Gly Ile Thr Thr Asp 
        275                 280                 285             


Leu Ser Pro Thr Tyr Thr Val Gln Leu Asp Lys Trp Ser Ala Leu Tyr 
    290                 295                 300                 


Pro Gly Ile Gly Ser Gly Val Ile Phe Lys Gly Tyr Leu Met Phe Pro 
305                 310                 315                 320 


Val Tyr Gly Gly Leu Pro Phe Lys Ser Pro Leu Ile Ser Ala Ser Trp 
                325                 330                 335     


Val Gly Pro Gly Asn Lys Trp Pro Val Asp Phe Ser Cys Ser Glu Asp 
            340                 345                 350         


Gln Tyr Ser Thr Phe Asn Phe Ser Asn Pro Tyr Ser Ala Leu Tyr Ser 
        355                 360                 365             


Pro His Phe Ser Asn Asn Ile Val Val Ser Ala Leu Phe Val Cys Pro 
    370                 375                 380                 


Leu Asn Glu Asn Leu Pro Tyr Ser Cys Glu Val Gln Val Leu Pro Gln 
385                 390                 395                 400 


Gly Asn Leu Thr Ile Gly Ala Glu Gly Arg Leu Tyr Val Ile Asp Gln 
                405                 410                 415     


Asp Leu Tyr Tyr Tyr Gln Arg Ser Thr Ser Trp Trp Pro Tyr Leu Gln 
            420                 425                 430         


Leu Tyr Lys Leu Asn Ile Arg Ile Thr Asn Arg Val Phe Arg Val Arg 
        435                 440                 445             


Ser Leu Ser Leu Leu Pro Ile Lys Ser Thr Thr Arg Pro Gly Tyr Gly 
    450                 455                 460                 


Asn Cys Thr Tyr Phe Lys Leu Cys Pro His Ile Cys Val Thr Gly Val 
465                 470                 475                 480 


Tyr Gln Ser Pro Trp Leu Ile Ser Ile Arg Asp Lys Arg Pro His Glu 
                485                 490                 495     


Glu Lys Asn Ile Leu Tyr Phe Ile Gly Trp Ser Pro Asp Glu Gln Ile 
            500                 505                 510         


Arg Gln Asn Pro Leu Val Ser Leu Cys His Glu Thr Ala Cys Phe Ile 
        515                 520                 525             


Asn Arg Ser Leu Ala Thr Asn Lys Thr His Ala Gly Tyr Ser Glu Ser 
    530                 535                 540                 


His Cys Val Gln Ser Phe Glu Arg Asn Lys Leu Thr Cys Thr Val Phe 
545                 550                 555                 560 


Tyr Glu Leu Thr Ala Lys Pro Trp Ala Glu Met Arg Val Gln Ser Leu 
                565                 570                 575     


Leu Phe Gln Val Asp Phe Leu 
            580             


<210>  430
<211>  595
<212>  PRT
<213>  Menangle pararubulavirus

<400>  430

Met Trp Asn Ser Ile Pro Gln Leu Val Ser Asp His Asp Gly Ala Lys 
1               5                   10                  15      


Gly Lys Phe Thr Asp Ile Pro Leu Gln Asp Asp Thr Asp Ser Gln Gln 
            20                  25                  30          


Pro Pro Gly Ser Lys Ser Thr Cys Arg Thr Leu Phe Arg Thr Val Leu 
        35                  40                  45              


Ile Ile Leu Ser Leu Ile Ile Leu Val Leu Gly Val Thr Ser Thr Met 
    50                  55                  60                  


Phe Ser Ala Lys Tyr Ser Gly Ser Cys Ala Thr Asn Ser Gln Leu Leu 
65                  70                  75                  80  


Gly Val Ser Asn Leu Ile Asn Gln Ile Gln Lys Ser Ile Asp Ser Leu 
                85                  90                  95      


Ile Ser Glu Val Asn Gln Val Ser Ile Thr Thr Ala Val Thr Leu Pro 
            100                 105                 110         


Val Lys Ile Met Asp Phe Gly Lys Ser Val Thr Asp Gln Val Thr Gln 
        115                 120                 125             


Met Ile Arg Gln Cys Asn Thr Val Cys Lys Gly Pro Gly Gln Lys Pro 
    130                 135                 140                 


Gly Ser Gln Asn Val Arg Ile Met Pro Ser Asn Asn Leu Ser Thr Phe 
145                 150                 155                 160 


Gln Asn Ile Asn Met Ser Ala Arg Gly Ile Ala Tyr Gln Asp Val Pro 
                165                 170                 175     


Leu Thr Phe Val Arg Pro Ile Lys Asn Pro Lys Ser Cys Ser Arg Phe 
            180                 185                 190         


Pro Ser Tyr Ser Val Ser Phe Gly Val His Cys Phe Ala Asn Ala Val 
        195                 200                 205             


Thr Asp Gln Thr Cys Glu Leu Asn Gln Asn Thr Phe Tyr Arg Val Val 
    210                 215                 220                 


Leu Ser Val Ser Lys Gly Asn Ile Ser Asp Pro Ser Ser Leu Glu Thr 
225                 230                 235                 240 


Lys Ala Glu Thr Arg Thr Pro Lys Gly Thr Pro Val Arg Thr Cys Ser 
                245                 250                 255     


Ile Ile Ser Ser Val Tyr Gly Cys Tyr Leu Leu Cys Ser Lys Ala Thr 
            260                 265                 270         


Ile Pro Glu Ser Glu Glu Met Lys Thr Val Gly Phe Ser Gln Met Phe 
        275                 280                 285             


Ile Leu Tyr Leu Ala Met Asp Ser Lys Arg Ile Leu Tyr Asp Asn Ile 
    290                 295                 300                 


Val Ser Ser Thr Ser Ala Ile Trp Ser Gly Leu Tyr Pro Gly Glu Gly 
305                 310                 315                 320 


Ala Gly Ile Trp His Met Gly Gln Leu Phe Phe Pro Leu Trp Gly Gly 
                325                 330                 335     


Ile Pro Phe Leu Thr Pro Leu Gly Gln Lys Ile Leu Asn Ser Thr Leu 
            340                 345                 350         


Asp Ile Pro Glu Val Gly Ser Lys Cys Lys Ser Ala Leu Thr Thr Ser 
        355                 360                 365             


Pro Ala Lys Thr Lys Asp Met Leu Phe Ser Pro Tyr Tyr Gly Glu Asn 
    370                 375                 380                 


Val Met Val Phe Gly Phe Leu Thr Cys Tyr Leu Leu Ser Asn Val Pro 
385                 390                 395                 400 


Thr Asn Cys His Ala Asp Tyr Leu Asn Ser Thr Val Leu Gly Phe Gly 
                405                 410                 415     


Ser Lys Ala Gln Phe Tyr Asp Tyr Arg Gly Ile Val Tyr Met Tyr Ile 
            420                 425                 430         


Gln Ser Ala Gly Trp Tyr Pro Tyr Thr Gln Ile Phe Arg Ile Thr Leu 
        435                 440                 445             


Gln Leu Lys Gln Asn Arg Leu Gln Ala Lys Ser Ile Lys Arg Ile Glu 
    450                 455                 460                 


Val Thr Ser Thr Thr Arg Pro Gly Asn Leu Glu Cys Ser Val Leu Trp 
465                 470                 475                 480 


Asn Cys Pro Tyr Ile Cys Ala Thr Gly Leu Phe Gln Ala Pro Trp Ile 
                485                 490                 495     


Val Asn Ser Asp Ala Ile Thr Pro Lys Glu Val Asp Asn Met Val Phe 
            500                 505                 510         


Val Gln Ala Trp Ser Ala Asp Phe Thr Glu Phe Arg Lys Gly Ile Leu 
        515                 520                 525             


Ser Leu Cys Ser Gln Val Ser Cys Pro Ile Asn Asp Leu Leu Ser Lys 
    530                 535                 540                 


Asp Asn Ser Tyr Met Arg Asp Thr Thr Thr Tyr Cys Phe Pro Gln Thr 
545                 550                 555                 560 


Val Pro Asn Thr Leu Pro Cys Thr Ser Phe Val Glu Trp Gly Gly Asp 
                565                 570                 575     


Ser Gly Asn Pro Ile Asn Ile Leu Glu Ile His Tyr Glu Val Ile Phe 
            580                 585                 590         


Val Ala Ser 
        595 


<210>  431
<211>  554
<212>  PRT
<213>  Menangle pararubulavirus

<400>  431

Met Ile Pro Arg Val Leu Gly Ile Ile Val Leu Tyr Leu Thr His Ser 
1               5                   10                  15      


Gln Ile Leu Cys Ile Asn Arg Asn Thr Leu Tyr Gln Ile Gly Leu Ile 
            20                  25                  30          


His Arg Ser Val Lys Lys Val Asn Phe Tyr Ser Gln Gly Ser Pro Ser 
        35                  40                  45              


Tyr Ile Val Val Lys Leu Val Pro Thr Leu Ala Ala Ile Pro Pro Asn 
    50                  55                  60                  


Cys Ser Ile Lys Ser Leu Gln Arg Tyr Lys Glu Thr Val Thr Ser Leu 
65                  70                  75                  80  


Val Gln Pro Ile Ser Asp Asn Leu Gly Tyr Leu Gln Asp Lys Leu Val 
                85                  90                  95      


Thr Gly Gln Ser Arg Arg Arg Arg Arg Phe Ala Gly Val Ala Ile Gly 
            100                 105                 110         


Leu Ala Ala Leu Gly Val Ala Ala Ala Ala Gln Ala Thr Ala Ala Val 
        115                 120                 125             


Ala Leu Val Glu Thr Arg Glu Asn Ala Gly Lys Ile Gln Ala Leu Ser 
    130                 135                 140                 


Glu Ser Ile Gln Asn Thr Asn Gln Ala Val His Ser Leu Lys Thr Ala 
145                 150                 155                 160 


Leu Gly Phe Ser Ala Thr Ala Ile Gln Ala Ile Gln Asn Gln Val Asn 
                165                 170                 175     


Glu Val Ile Asn Pro Ala Ile Asn Lys Leu Ser Cys Glu Val Leu Asp 
            180                 185                 190         


Ser Gln Leu Ala Ser Met Leu Asn Leu Tyr Leu Ile His Leu Thr Thr 
        195                 200                 205             


Val Phe Gln Thr Gln Leu Thr Asn Pro Ala Leu Thr Pro Leu Ser Ile 
    210                 215                 220                 


Gln Ala Leu Thr Ser Val Leu Gln Gly Thr Ser Gly Val Leu Met Asn 
225                 230                 235                 240 


Ser Thr Asn Ser Thr Leu Thr Gln Pro Met Asp Leu Leu Ala Thr Gly 
                245                 250                 255     


Leu Ile Thr Gly Gln Ile Ile Ser Val Asn Met Thr Ser Leu Gln Leu 
            260                 265                 270         


Ile Ile Ala Thr Phe Met Pro Ser Ile Ala Glu Leu Pro Asn Ala Val 
        275                 280                 285             


Leu His Ser Phe Phe Arg Ile Thr Thr Ser Val Asn Leu Thr Glu Val 
    290                 295                 300                 


Met Ile Gln Ser Pro Glu Phe Ile Met Glu Gln Asn Gly Val Phe Tyr 
305                 310                 315                 320 


Asp Phe Asn Thr Ala His Cys Gln Leu Gly Asp Asn Asn Val Tyr Cys 
                325                 330                 335     


Pro Tyr Ile Asp Ala Ala Arg Leu Ser Ser Thr Met Thr Asn Cys Ile 
            340                 345                 350         


Asn Gly Lys Leu Gly Asp Cys Val Phe Ser Arg Val Ile Gly Ser Phe 
        355                 360                 365             


Pro Ser Arg Phe Val Ser Leu Asn Gly Ala Ile Leu Ala Asn Cys Lys 
    370                 375                 380                 


Phe Met Arg Cys Asn Cys Leu Ala Pro Glu Lys Ile Ile Thr Pro Leu 
385                 390                 395                 400 


Asp Gly Glu Met Ile Ser Leu Ile Asp Leu Arg Val Cys Gln Lys Leu 
                405                 410                 415     


Thr Leu Gly Thr Ile Thr Phe Glu Ile Ser Gln Pro Val Asn Val Ser 
            420                 425                 430         


Phe Gln Gly Gly Phe Val Ala Asn Ala Gly Gln Ile Ile Val Thr Asn 
        435                 440                 445             


Pro Phe Asp Ile Ser Ala Glu Leu Gly Gln Ile Asn Asn Ser Leu Asn 
    450                 455                 460                 


Asp Ala Gln Gly Phe Leu Asp Gln Ser Asn Asn Trp Leu Lys Val Ser 
465                 470                 475                 480 


Gly Trp Ile Ser Asn Ser Gly Ser Leu Phe Ile Ala Gly Ile Val Val 
                485                 490                 495     


Ile Gly Leu Ile Val Leu Cys Ile Val Ile Ile Ile Tyr Ile Asn Val 
            500                 505                 510         


Gln Ile Ile Arg Glu Val Asn Arg Leu Arg Ser Phe Ile Tyr Arg Asp 
        515                 520                 525             


Tyr Val Leu Asp His Asp Lys Ala Pro Tyr Ser Pro Glu Leu Ser Ser 
    530                 535                 540                 


Pro His Arg Lys Ser Leu Lys Thr Val Ser 
545                 550                 


<210>  432
<211>  582
<212>  PRT
<213>  Sosuga pararubulavirus

<400>  432

Met His Ala Arg Asn Ser Ser Val Ser Ser Ile Ser Asp Ser Ile Asp 
1               5                   10                  15      


Asn Val Phe Gly Lys Arg Asn Thr Pro Val Ile Lys Arg Thr Gly Lys 
            20                  25                  30          


Lys Leu Phe Arg Leu Gly Ser Leu Ile Phe Leu Ile Val Ile Ile Ser 
        35                  40                  45              


Leu Thr Val Lys Ile Ile Thr Glu Leu Ser Leu Val Lys Ser Glu Cys 
    50                  55                  60                  


Ser Asn Arg Asp His Val Thr Glu Ile Ile Asn Leu Gln Gln Lys Glu 
65                  70                  75                  80  


Leu Ser Leu Met Asn Asn Ile Ile Thr Thr Leu Asn Thr Leu Leu Thr 
                85                  90                  95      


Thr Thr Thr Val Asp Leu Pro Ile Lys Leu Thr Asn Phe Gly Lys Ser 
            100                 105                 110         


Ile Val Asp Gln Val Thr Met Met Val Arg Gln Cys Asn Ala Val Cys 
        115                 120                 125             


Arg Gly Pro Gly Asp Lys Pro Thr Gln Asn Ile Gln Leu Phe Asn Gly 
    130                 135                 140                 


Arg Tyr Ala Ile Ile Asn Asn Ser Thr Ala Tyr Pro Ser Arg Asn Ser 
145                 150                 155                 160 


Ile Ser Glu Leu Lys Val Pro Arg Asp Phe Val Pro Ser Pro Gly Thr 
                165                 170                 175     


Phe His Gly Cys Ser Arg Phe Pro Ser Tyr Ser Asn His Tyr Gly Leu 
            180                 185                 190         


Trp Cys Tyr Ser His Thr Val Ser Asn Asp Thr Cys Asp Gly Ser Asn 
        195                 200                 205             


Pro Ser Val Gln Ile Leu Ser Val Gly Lys Leu Ile Thr Gly Asp Asn 
    210                 215                 220                 


Gly Gln Pro Glu His Lys Thr Leu Tyr Thr Gln Gln Leu Ser Gln Thr 
225                 230                 235                 240 


Asp Arg Leu Tyr His Cys Ser Val Thr Met Thr Thr Leu Gly Cys Tyr 
                245                 250                 255     


Ile Leu Cys Ser Lys Pro Arg Val Asn Glu Thr Gln Asp Tyr Glu Thr 
            260                 265                 270         


Ile Gly Ile Glu Pro Met Ile Ile Gly Met Leu Gly Leu Asp Gly Val 
        275                 280                 285             


Tyr Thr Asp Leu Gly Asn Pro Val Gly Ile Ser Asp Asn Ser Leu Tyr 
    290                 295                 300                 


Ala Met Tyr Pro Gly Pro Gly Gly Gly Val Met Tyr Lys Asp Phe Leu 
305                 310                 315                 320 


Val Phe Pro Leu His Gly Gly Val Arg Phe Ser Glu Ala Ser Lys Met 
                325                 330                 335     


Leu Gly Lys Asn Ile Thr Phe Arg Gly Phe Pro Pro Ser Asp Thr Cys 
            340                 345                 350         


Thr Glu His Glu Lys Ser Leu Thr Gln Glu Pro Ala Asn Met Leu Thr 
        355                 360                 365             


Ser Pro Tyr Tyr Gly Glu Val Leu Val Leu Asp Phe Leu Tyr Val Cys 
    370                 375                 380                 


Thr Leu Leu Asp Asn Ile Pro Gly Glu Cys Ser Ile Gln Leu Ile Pro 
385                 390                 395                 400 


Pro Asp Asn Met Thr Met Gly Ser Glu Ser Lys Leu Tyr Lys Leu Asn 
                405                 410                 415     


Asn Ser Leu Leu Leu Tyr Lys Arg Ser Ser Ser Trp Trp Pro Tyr Thr 
            420                 425                 430         


Glu Val Tyr Gln Leu Ser Leu Arg Val Ser Lys Asn Ser Met Lys Val 
        435                 440                 445             


Arg Glu Ser Val Arg Leu Asn Ile Thr Ser Thr Thr Arg Pro Gly Val 
    450                 455                 460                 


Glu Gly Cys Asn Ile Asn Lys Val Cys Pro Lys Val Cys Val Thr Gly 
465                 470                 475                 480 


Val Phe Gln Ala Pro Gly Ile Ile Arg Lys Ala Leu Ser Pro Lys Glu 
                485                 490                 495     


Ser Asn Glu Asp Leu Leu Phe Phe Gln Ala Trp Thr Ser Asp Ser Ile 
            500                 505                 510         


Ala Arg Gln Gly Pro Leu Ile Ser Leu Cys Arg Ala Asp Ser Cys Val 
        515                 520                 525             


Leu Thr Ile Pro Leu Gly Asn Ser Asp Val Phe Ile Gly Tyr Thr Asp 
    530                 535                 540                 


Ser Phe Cys Leu Ser Asp Arg Asp Asn Glu Lys Ile Tyr Cys Val Ala 
545                 550                 555                 560 


Leu Leu Glu Leu Asp Asn Met Pro Tyr Ser Glu Met Thr Ile Arg Ser 
                565                 570                 575     


Phe Leu Tyr Leu Ile Lys 
            580         


<210>  433
<211>  534
<212>  PRT
<213>  Sosuga pararubulavirus

<400>  433

Met Ala His Ile Asn Ser Leu Ile Leu Leu Leu Met Leu Thr Glu Thr 
1               5                   10                  15      


Gly Ser Ser Val Asn Ile Gln Leu Leu Gln Ser Leu Gly Val Ile Asn 
            20                  25                  30          


Thr His Lys Arg Gln Leu Ala Phe Tyr Asn Gln Gln Pro Pro Ser Tyr 
        35                  40                  45              


Leu Val Ile Arg Leu Leu Pro Thr Leu Asn Ile Pro Lys Gln Asn Cys 
    50                  55                  60                  


Thr Leu Asn Ser Ile Asn Arg Tyr Glu Lys Ala Val Lys Asp Ile Ile 
65                  70                  75                  80  


Lys Pro Ile Ser Asp Asn Leu Asn Trp Leu Ser Asp Asn Leu Ile Pro 
                85                  90                  95      


Lys Arg Arg Gly Lys Arg Phe Ala Gly Ala Ala Ile Gly Leu Ala Ala 
            100                 105                 110         


Leu Gly Val Ala Val Ala Ala Gln Ala Thr Ala Ala Val Ala Leu Val 
        115                 120                 125             


Glu Ala Arg Ala Asn Ala Glu Lys Ile Ser Ser Met Ser Ala Ala Leu 
    130                 135                 140                 


Gln Glu Thr Asn Gln Ala Val Ser Ser Leu Thr Ala Ala Met Ala Ser 
145                 150                 155                 160 


Ser Gly Ile Ala Ile Gln Ala Ile Gln Asn Glu Ile Asn Asn Val Ile 
                165                 170                 175     


His Pro Ile Leu Asn Gln Val Gln Cys Gly Val Leu Asp Ser Gln Ile 
            180                 185                 190         


Ala Ser Ile Leu Asn Leu Tyr Leu Ile Lys Ile Thr Thr Ile Phe Asn 
        195                 200                 205             


Asn Gln Leu Thr Asn Pro Ala Leu His Arg Ile Ser Ile Gln Ala Leu 
    210                 215                 220                 


Ser Val Leu Met Gln Ser Thr Lys Asp Ser Leu Lys Asn Leu Thr Ala 
225                 230                 235                 240 


Gly Asp Thr Gln Thr Ser Leu Asp Leu Ile Arg Thr Asn Leu Ile Glu 
                245                 250                 255     


Gly Gln Ile Val Ala Val Asn Met Thr Thr Leu Gln Met Val Ile Ala 
            260                 265                 270         


Val Tyr Ile Pro Ala Val Ala Lys Leu Glu Ser Ala Val Leu Leu Asp 
        275                 280                 285             


Phe Ile Ser Ile Thr Val Ser Ser Asn Gln Ser Glu Val Met Leu Gln 
    290                 295                 300                 


Leu Pro Ser Arg Ile Leu Glu Val Gly Asn Asn Ile Tyr Thr Phe Lys 
305                 310                 315                 320 


Gly Asp Gln Cys Thr Leu Thr Glu Thr Thr Ala Tyr Cys Leu Tyr Ser 
                325                 330                 335     


Asp Ala Val Pro Val Asn Glu Lys Ile Ser Asp Cys Met Lys Gly Ile 
            340                 345                 350         


Gln Ser Ser Cys Ile Phe Thr Arg Ile Ile Gly Ser Phe Ala Asn Arg 
        355                 360                 365             


Phe Ala Ser Val Asn Gly Ala Ile Phe Ala Asn Cys Lys Ser Leu Thr 
    370                 375                 380                 


Cys Ser Cys Thr Gln Pro Asp Gly Leu Ile Tyr Gln Pro Asp Asn Val 
385                 390                 395                 400 


Pro Leu Thr Ile Ile Asp Lys Ile Lys Cys Ser Lys Leu Asn Ile Gly 
                405                 410                 415     


His Leu Thr Phe Asn Ile Arg Asp Ser Thr Asn Ala Thr Ile Asp Leu 
            420                 425                 430         


His Thr Asp Leu Ser Asp Ser Gln Ile Thr Ile Thr Asn Pro Leu Asp 
        435                 440                 445             


Leu Ser Ala Glu Leu Thr Gln Ile Asn Asn Ser Val Ile Asn Ser His 
    450                 455                 460                 


Leu His Leu Met Asn Ser Glu Asn Ile Leu Arg Arg Ile Asp Ser Gly 
465                 470                 475                 480 


Leu Phe Ser Lys Ala Ile Met Ile Phe Leu Leu Val Gly Val Cys Ser 
                485                 490                 495     


Leu Ile Ile Val Val Ile Gly Leu Ile Val Trp Ile Arg Phe Ile Leu 
            500                 505                 510         


Leu His Leu Lys Ser Ser Ser His Thr Asn Arg Gln Gly Ser Ser Leu 
        515                 520                 525             


Phe Ser Ile Asp Ser Val 
    530                 


<210>  434
<211>  538
<212>  PRT
<213>  Teviot pararubulavirus

<400>  434

Met Asn Leu Leu Lys Val His Leu Leu Leu Met Leu Tyr Pro Ser Cys 
1               5                   10                  15      


Ile Cys Gly Ile Asn Lys Asp Lys Leu Leu Ser Ile Gly Leu Val His 
            20                  25                  30          


Lys Ser Val Lys Asn Leu Met Phe Tyr Ser Gln Gly Ser Pro Ser Tyr 
        35                  40                  45              


Ile Val Val Lys Leu Val Pro Thr Leu Gly Asn Leu Pro Glu Asn Cys 
    50                  55                  60                  


Thr Leu Asn Ser Leu Lys Arg Tyr Lys Ser Thr Val Thr Ser Leu Leu 
65                  70                  75                  80  


Thr Pro Leu Ser Asp Asn Leu Asn Tyr Leu Gln Gln Thr Leu Thr Val 
                85                  90                  95      


Ser Lys Gly Ser Arg Arg Arg Arg Phe Ala Gly Val Ala Ile Gly Leu 
            100                 105                 110         


Ala Ala Leu Gly Val Ala Ala Ala Ala Gln Ala Thr Ala Ala Val Ala 
        115                 120                 125             


Leu Val Glu Ala Arg Gln Asn Ala Ala Gln Ile Gln Ser Leu Ser Glu 
    130                 135                 140                 


Ser Ile Gln Asn Thr Asn Leu Ala Val Asn Glu Leu Lys Thr Ala Ile 
145                 150                 155                 160 


Gly Ala Ser Ala Val Ala Ile Gln Ala Ile Gln Thr Gln Val Asn Asp 
                165                 170                 175     


Val Ile Asn Pro Ala Ile Asn Arg Leu Ser Cys Glu Val Leu Asp Ala 
            180                 185                 190         


Gln Leu Ala Ser Met Leu Asn Leu Tyr Leu Ile His Leu Thr Thr Val 
        195                 200                 205             


Phe Gln Asn Gln Ile Thr Asn Pro Ala Leu Ser Pro Leu Ser Ile Gln 
    210                 215                 220                 


Ser Leu Gln Ser Leu Leu Gln Ser Thr Ser Gly Ile Leu Thr Asn Met 
225                 230                 235                 240 


Thr Ala Gly Ser Asn Leu Val Leu Asn Asp Ala Leu Ala Thr Gly Leu 
                245                 250                 255     


Ile Thr Gly Gln Val Val Gly Met Asn Leu Thr Ser Leu Gln Ile Val 
            260                 265                 270         


Ile Ala Ala Tyr Val Pro Asn Val Ala Lys Leu Thr Asn Ala Ile Val 
        275                 280                 285             


His Gln Phe Ile Arg Ile Thr Thr Ser Val Asn Gly Thr Glu Val Ile 
    290                 295                 300                 


Val Gln Ser Pro Thr Gln Ile Met Glu Gln Asn Glu Val Met Tyr Glu 
305                 310                 315                 320 


Leu Arg Ser Asp His Cys Ser Glu Ser Val Met Asn Ile Tyr Cys Pro 
                325                 330                 335     


Tyr Ile Asp Ala Gln Leu Met Pro Pro Thr Ser Thr Asn Cys Ile Asn 
            340                 345                 350         


Gly Gln Leu Asn Asp Cys Thr Phe Ser Lys Val Val Gly Ser Phe Pro 
        355                 360                 365             


Thr Arg Phe Ala Ala Val Glu Gly Ala Ile Leu Ala Asn Cys Lys Tyr 
    370                 375                 380                 


Leu Gln Cys Asn Cys Leu Val Pro Pro Tyr Ile Ile Thr Pro Leu Lys 
385                 390                 395                 400 


Gly Glu Met Ile Ser Met Ile Asn Leu Ser Lys Cys Gln Arg Leu Asp 
                405                 410                 415     


Leu Gly Thr Val Val Phe Glu Ile Asn Asn Pro Val Asn Val Thr Phe 
            420                 425                 430         


Asn Gly Asn Tyr Arg Ala Asp Val Gly Gln Leu Ile Val Thr Asn Pro 
        435                 440                 445             


Leu Asp Ile Ser Ala Glu Leu Asn Gln Ile Asn Thr Ser Leu Ser Asn 
    450                 455                 460                 


Ala Gln Thr Phe Leu Ser Lys Ser Asp Ala Trp Leu Arg Val Ser Gln 
465                 470                 475                 480 


Trp Leu Ser Asn Ser Gly Thr Ile Phe Ile Ile Leu Leu Ile Gly Leu 
                485                 490                 495     


Gly Ile Gly Val Ile Tyr Met Val Ile Asn Thr Tyr Val Val Val Gln 
            500                 505                 510         


Ile Ile Lys Glu Ile Asn Arg Ile Arg Asp Lys Asp Arg Ala His Leu 
        515                 520                 525             


Leu Lys Gly Ser Val Ser Ser Ile Ser Met 
    530                 535             


<210>  435
<211>  595
<212>  PRT
<213>  Teviot pararubulavirus

<400>  435

Met Trp Ser Thr Gln Ala Ser Lys His Pro Ala Met Val Asn Ser Ala 
1               5                   10                  15      


Thr Asn Leu Val Asp Ile Pro Leu Asp His Pro Ser Ser Ala Gln Phe 
            20                  25                  30          


Pro Ile Asn Arg Lys Arg Thr Gly Arg Leu Ile Tyr Arg Leu Phe Ser 
        35                  40                  45              


Ile Leu Cys Asn Leu Ile Leu Ile Ser Ile Leu Ile Ser Leu Val Val 
    50                  55                  60                  


Ile Trp Ser Arg Ser Ser Arg Asp Cys Ala Lys Ser Asp Gly Leu Ser 
65                  70                  75                  80  


Ser Val Asp Asn Gln Leu Ser Ser Leu Ser Arg Ser Ile Asn Ser Leu 
                85                  90                  95      


Ile Thr Glu Val Asn Gln Ile Ser Val Thr Thr Ala Ile Asn Leu Pro 
            100                 105                 110         


Ile Lys Leu Ser Glu Phe Gly Lys Ser Val Val Asp Gln Val Thr Gln 
        115                 120                 125             


Met Ile Arg Gln Cys Asn Ala Ala Cys Lys Gly Pro Gly Glu Lys Pro 
    130                 135                 140                 


Gly Ile Gln Asn Val Arg Ile Asn Ile Pro Asn Asn Phe Ser Thr Tyr 
145                 150                 155                 160 


Ser Glu Leu Asn Arg Thr Ala Asn Ser Leu Asn Phe Gln Ser Arg Thr 
                165                 170                 175     


Ala Leu Phe Ala Arg Pro Asn Pro Tyr Pro Lys Thr Cys Ser Arg Phe 
            180                 185                 190         


Pro Ser Tyr Ser Val Tyr Phe Gly Ile His Cys Phe Ser His Ala Val 
        195                 200                 205             


Thr Asp Ser Ser Cys Glu Leu Ser Asp Ser Thr Tyr Tyr Arg Leu Val 
    210                 215                 220                 


Ile Gly Val Ala Asp Lys Asn Leu Ser Asp Pro Ala Asp Val Lys Tyr 
225                 230                 235                 240 


Ile Gly Glu Thr Thr Thr Pro Val Arg Val Gln Thr Arg Gly Cys Ser 
                245                 250                 255     


Val Val Ser Ser Ile Tyr Gly Cys Tyr Leu Leu Cys Ser Lys Ser Asn 
            260                 265                 270         


Gln Asp Tyr Gln Asp Asp Phe Arg Glu Gln Gly Phe His Gln Met Phe 
        275                 280                 285             


Ile Leu Phe Leu Ser Arg Glu Leu Lys Thr Thr Phe Phe Asp Asp Met 
    290                 295                 300                 


Val Ser Ser Thr Thr Val Thr Trp Asn Gly Leu Tyr Pro Gly Glu Gly 
305                 310                 315                 320 


Ser Gly Ile Trp His Met Gly His Leu Val Phe Pro Leu Trp Gly Gly 
                325                 330                 335     


Ile Arg Phe Gly Thr His Ala Ser Glu Gly Ile Leu Asn Ser Thr Leu 
            340                 345                 350         


Glu Leu Pro Pro Val Gly Pro Ser Cys Lys Arg Ser Leu Ala Asp Asn 
        355                 360                 365             


Gly Leu Ile Asn Lys Asp Val Leu Phe Ser Pro Tyr Phe Gly Asp Ser 
    370                 375                 380                 


Val Met Val Phe Ala Tyr Leu Ser Cys Tyr Met Leu Ser Asn Val Pro 
385                 390                 395                 400 


Thr His Cys Gln Val Glu Thr Met Asn Ser Ser Val Leu Gly Phe Gly 
                405                 410                 415     


Ser Arg Ala Gln Phe Tyr Asp Leu Lys Gly Ile Val Tyr Leu Tyr Ile 
            420                 425                 430         


Gln Ser Ala Gly Trp Phe Ser Tyr Thr Gln Leu Phe Arg Leu Ser Leu 
        435                 440                 445             


Gln Ser Lys Gly Tyr Lys Leu Ser Val Lys Gln Ile Lys Arg Ile Pro 
    450                 455                 460                 


Ile Ser Ser Thr Ser Arg Pro Gly Thr Glu Pro Cys Asp Ile Ile His 
465                 470                 475                 480 


Asn Cys Pro Tyr Thr Cys Ala Thr Gly Leu Phe Gln Ala Pro Trp Ile 
                485                 490                 495     


Val Asn Gly Asp Ser Ile Arg Asp Arg Asp Val Arg Asn Met Ala Phe 
            500                 505                 510         


Val Gln Ala Trp Ser Gly Ala Ile Asn Thr Phe Gln Arg Pro Phe Met 
        515                 520                 525             


Ser Ile Cys Ser Gln Tyr Ser Cys Pro Leu Ser Glu Leu Leu Asp Ser 
    530                 535                 540                 


Glu Ser Ser Ile Met Arg Ser Thr Thr Thr Tyr Cys Phe Pro Ser Leu 
545                 550                 555                 560 


Thr Glu Ser Ile Leu Gln Cys Val Ser Phe Ile Glu Trp Gly Gly Pro 
                565                 570                 575     


Val Gly Asn Pro Ile Ser Ile Asn Glu Val Tyr Ser Ser Ile Ser Phe 
            580                 585                 590         


Arg Pro Asp 
        595 


<210>  436
<211>  538
<212>  PRT
<213>  Tioman pararubulavirus

<400>  436

Met Arg Ile Ala Leu Thr Ala Val Ile Val Ser Ile His Phe Asp Leu 
1               5                   10                  15      


Ala Phe Pro Met Asn Lys Asn Ser Leu Leu Ser Val Gly Leu Val His 
            20                  25                  30          


Lys Ser Val Lys Asn Leu Tyr Phe Tyr Ser Gln Gly Ser Pro Ser Tyr 
        35                  40                  45              


Ile Val Val Lys Leu Val Pro Thr Leu Gly Asn Val Pro Gly Asn Cys 
    50                  55                  60                  


Thr Leu Asn Ser Leu Val Arg Tyr Lys Ser Thr Val Ser Ser Leu Leu 
65                  70                  75                  80  


Ser Pro Leu Ala Glu Asn Leu Glu Tyr Leu Gln Lys Thr Leu Thr Val 
                85                  90                  95      


Ser Arg Gly Gly Arg Arg Arg Arg Phe Ala Gly Val Ala Ile Gly Leu 
            100                 105                 110         


Ala Ala Leu Gly Val Ala Ala Ala Ala Gln Ala Thr Ala Ala Val Ala 
        115                 120                 125             


Leu Val Glu Ala Arg Gln Asn Ala Ala Gln Ile Gln Ser Leu Ser Glu 
    130                 135                 140                 


Ala Ile Gln Asn Thr Asn Leu Ala Val Asn Glu Leu Lys Thr Ala Ile 
145                 150                 155                 160 


Gly Ala Ser Ala Thr Ala Ile Gln Ala Ile Gln Thr Gln Ile Asn Glu 
                165                 170                 175     


Val Ile Asn Pro Ala Ile Asn Arg Leu Ser Cys Glu Ile Leu Asp Ala 
            180                 185                 190         


Gln Leu Ala Ser Met Leu Asn Leu Tyr Leu Ile His Leu Thr Thr Val 
        195                 200                 205             


Phe Gln Asn Gln Leu Thr Asn Pro Ala Leu Thr Pro Leu Ser Ile Gln 
    210                 215                 220                 


Ser Leu Gln Ser Leu Leu Gln Gly Thr Ser Ser Val Leu Thr Asn Ile 
225                 230                 235                 240 


Thr Ser Ser Ser Lys Leu Ala Leu Asn Asp Ala Leu Val Thr Gly Leu 
                245                 250                 255     


Ile Thr Gly Gln Val Val Gly Leu Asn Met Thr Ser Leu Gln Ile Val 
            260                 265                 270         


Ile Ala Ala Tyr Val Pro Ser Val Ala Lys Leu Ser Asn Ala Val Val 
        275                 280                 285             


His Asn Phe Ile Arg Ile Thr Thr Ser Val Asn Gly Thr Glu Val Ile 
    290                 295                 300                 


Ile Gln Ser Pro Thr Ile Ile Met Glu Gln Asn Glu Val Met Tyr Asp 
305                 310                 315                 320 


Leu Lys Thr Gly His Cys Thr Glu Ser Asp Leu Asn Ile Tyr Cys Pro 
                325                 330                 335     


Tyr Val Asp Ala Gln Leu Leu Ser Pro Gly Met Thr Asn Cys Ile Asn 
            340                 345                 350         


Gly Arg Leu Asn Asp Cys Thr Phe Ser Lys Val Val Gly Ser Phe Pro 
        355                 360                 365             


Thr Arg Phe Ala Ala Val Glu Gly Ala Ile Leu Ala Asn Cys Lys Tyr 
    370                 375                 380                 


Leu Gln Cys Asn Cys Leu Thr Pro Pro Tyr Ile Ile Thr Pro Leu Asn 
385                 390                 395                 400 


Gly Glu Met Ile Ser Met Ile Asp Leu Ser Lys Cys Gln Arg Leu Asp 
                405                 410                 415     


Leu Gly Thr Ile Val Phe Asp Ile Asn Asn Pro Val Asn Val Thr Phe 
            420                 425                 430         


Asn Gly Asn Tyr Arg Ala Asp Val Gly Gln Met Ile Val Thr Asn Pro 
        435                 440                 445             


Leu Asp Ile Ser Ala Glu Leu Asn Gln Ile Asn Thr Ser Leu Ser Asn 
    450                 455                 460                 


Ala Gln Gly Phe Leu Ser Lys Ser Asp Ala Trp Leu His Val Ser Gln 
465                 470                 475                 480 


Trp Val Thr Asn Ser Gly Thr Ile Phe Ile Ile Leu Ile Ile Gly Leu 
                485                 490                 495     


Ile Val Gly Ile Val Tyr Met Ile Ile Asn Thr Tyr Val Val Val Gln 
            500                 505                 510         


Ile Ile Lys Glu Ile Asn Arg Met Arg Thr Ser Asp Arg Ala His Leu 
        515                 520                 525             


Leu Lys Gly Ser Ile Ser Ser Ile Ser Thr 
    530                 535             


<210>  437
<211>  593
<212>  PRT
<213>  Tioman pararubulavirus

<400>  437

Met Trp Ala Thr Ser Glu Ser Lys Ala Pro Ile Pro Ala Asn Ser Thr 
1               5                   10                  15      


Leu Asn Leu Val Asp Val Pro Leu Asp Glu Pro Gln Thr Ile Thr Lys 
            20                  25                  30          


His Arg Lys Gln Lys Arg Thr Gly Arg Leu Val Phe Arg Leu Leu Ser 
        35                  40                  45              


Leu Val Leu Ser Leu Met Thr Val Ile Leu Val Leu Val Ile Leu Ala 
    50                  55                  60                  


Ser Trp Ser Gln Lys Ile Asn Ala Cys Ala Thr Lys Glu Gly Phe Asn 
65                  70                  75                  80  


Ser Leu Asp Leu Gln Ile Ser Gly Leu Val Lys Ser Ile Asn Ser Leu 
                85                  90                  95      


Ile Thr Glu Val Asn Gln Ile Ser Ile Thr Thr Ala Ile Asn Leu Pro 
            100                 105                 110         


Ile Lys Leu Ser Asp Phe Gly Lys Ser Ile Val Asp Gln Val Thr Gln 
        115                 120                 125             


Met Ile Arg Gln Cys Asn Ala Val Cys Lys Gly Pro Gly Glu Lys Pro 
    130                 135                 140                 


Gly Ile Gln Asn Ile Arg Ile Asn Ile Pro Asn Asn Phe Ser Thr Tyr 
145                 150                 155                 160 


Leu Glu Leu Asn Asn Thr Val Lys Ser Ile Glu Leu Gln Arg Arg Pro 
                165                 170                 175     


Ala Leu Leu Ala Arg Pro Asn Pro Ile Pro Lys Ser Cys Ser Arg Phe 
            180                 185                 190         


Pro Ser Tyr Ser Val Asn Phe Gly Ile His Cys Phe Ala His Ala Ile 
        195                 200                 205             


Thr Asp Gln Ser Cys Glu Leu Ser Asp Lys Thr Tyr Tyr Arg Leu Ala 
    210                 215                 220                 


Ile Gly Ile Ser Asp Lys Asn Leu Ser Asp Pro Ser Asp Val Lys Tyr 
225                 230                 235                 240 


Ile Gly Glu Ala Phe Thr Pro Met Gly Leu Gln Ala Arg Gly Cys Ser 
                245                 250                 255     


Val Ile Ser Ser Ile Tyr Gly Cys Tyr Leu Leu Cys Ser Lys Ser Asn 
            260                 265                 270         


Gln Gly Tyr Glu Ala Asp Phe Gln Thr Gln Gly Phe His Gln Met Tyr 
        275                 280                 285             


Ile Leu Phe Leu Ser Arg Asp Leu Lys Thr Thr Leu Phe Asn Asp Met 
    290                 295                 300                 


Ile Ser Ser Thr Thr Val Val Trp Asn Gly Leu Tyr Pro Gly Glu Gly 
305                 310                 315                 320 


Ala Gly Ile Trp His Met Gly Tyr Leu Ile Phe Pro Leu Trp Gly Gly 
                325                 330                 335     


Ile Lys Ile Gly Thr Pro Ala Ser Thr Ser Ile Leu Asn Ser Thr Leu 
            340                 345                 350         


Asp Leu Pro Leu Val Gly Pro Ser Cys Lys Ser Thr Leu Glu Glu Asn 
        355                 360                 365             


Asn Leu Ile Asn Lys Asp Val Leu Phe Ser Pro Tyr Phe Gly Glu Ser 
    370                 375                 380                 


Val Met Val Phe Gly Phe Leu Ser Cys Tyr Met Leu Ser Asn Val Pro 
385                 390                 395                 400 


Thr His Cys Gln Val Glu Val Leu Asn Ser Ser Val Leu Gly Phe Gly 
                405                 410                 415     


Ser Arg Ser Gln Leu Met Asp Leu Lys Gly Ile Val Tyr Leu Tyr Ile 
            420                 425                 430         


Gln Ser Ala Gly Trp Tyr Ser Tyr Thr Gln Leu Phe Arg Leu Ser Leu 
        435                 440                 445             


Gln Ser Arg Gly Tyr Lys Leu Thr Val Lys Gln Ile Arg Arg Ile Pro 
    450                 455                 460                 


Ile Ser Ser Thr Thr Arg Pro Gly Thr Ala Pro Cys Asp Val Val His 
465                 470                 475                 480 


Asn Cys Pro Tyr Thr Cys Ala Thr Gly Leu Phe Gln Ala Pro Trp Ile 
                485                 490                 495     


Val Asn Gly Asp Ser Ile Leu Asp Arg Asp Val Arg Asn Leu Val Phe 
            500                 505                 510         


Val Gln Ala Trp Ser Gly Asn Phe Asn Thr Phe Gln Lys Gly Leu Ile 
        515                 520                 525             


Ser Ile Cys Asn Gln Tyr Thr Cys Pro Leu Thr Thr Leu Leu Asp Asn 
    530                 535                 540                 


Asp Asn Ser Ile Met Arg Ser Thr Thr Thr Tyr Cys Tyr Pro Ser Leu 
545                 550                 555                 560 


Ser Glu Tyr Asn Leu Gln Cys Gln Ser Phe Ile Glu Trp Gly Gly Pro 
                565                 570                 575     


Val Gly Asn Pro Ile Gly Ile Leu Glu Val His Tyr Ile Ile Lys Phe 
            580                 585                 590         


Lys 
    


<210>  438
<211>  532
<212>  PRT
<213>  Tuhoko pararubulavirus 1

<400>  438

Met Val Thr Ile Ile Lys Pro Leu Ile Leu Leu Val Thr Val Ile Leu 
1               5                   10                  15      


Gln Ile Ser Gly His Ile Asp Thr Thr Ala Leu Thr Ser Ile Gly Ala 
            20                  25                  30          


Val Ile Ala Ser Ser Lys Glu Ile Met Tyr Tyr Ala Gln Ser Thr Pro 
        35                  40                  45              


Asn Tyr Ile Val Ile Lys Leu Ile Pro Asn Leu Pro Asn Ile Pro Ser 
    50                  55                  60                  


Gln Cys Asn Phe Ser Ser Ile Ala Tyr Tyr Asn Lys Thr Leu Leu Asp 
65                  70                  75                  80  


Leu Phe Thr Pro Ile Ser Asp Asn Ile Asn Met Leu His Gln Arg Leu 
                85                  90                  95      


Ser Asn Thr Gly Arg Asn Arg Arg Phe Ala Gly Val Ala Ile Gly Leu 
            100                 105                 110         


Ala Ala Leu Gly Val Ala Thr Ala Ala Gln Val Thr Ala Ala Phe Ala 
        115                 120                 125             


Leu Val Glu Ala Lys Ser Asn Thr Ala Lys Ile Ala Gln Ile Gly Gln 
    130                 135                 140                 


Ala Ile Gln Asn Thr Asn Ala Ala Ile Asn Ser Leu Asn Ala Gly Ile 
145                 150                 155                 160 


Gly Gly Ala Val Thr Ala Ile Gln Ala Ile Gln Thr Gln Ile Asn Gly 
                165                 170                 175     


Ile Ile Thr Asp Gln Ile Asn Ala Ala Thr Cys Thr Ala Leu Asp Ala 
            180                 185                 190         


Gln Ile Gly Thr Leu Leu Asn Met Tyr Leu Leu Gln Leu Thr Thr Thr 
        195                 200                 205             


Phe Gln Pro Gln Ile Gln Asn Pro Ala Leu Gln Pro Leu Ser Ile Gln 
    210                 215                 220                 


Ala Leu His Arg Ile Met Gln Gly Thr Ser Ile Val Leu Ser Asn Leu 
225                 230                 235                 240 


Thr Asp Ser Ser Lys Tyr Gly Leu Asn Asp Ala Leu Ser Ala Gly Leu 
                245                 250                 255     


Ile Thr Gly Gln Ile Val Ser Val Asp Leu Arg Leu Met Gln Ile Thr 
            260                 265                 270         


Ile Ala Ala Asn Val Pro Thr Leu Ser Arg Leu Glu Asn Ala Ile Ala 
        275                 280                 285             


His Asp Ile Met Arg Ile Thr Thr Asn Val Asn Asn Thr Glu Val Ile 
    290                 295                 300                 


Val Gln Leu Pro Glu Thr Ile Met Glu His Ala Gly Arg Leu Tyr Gln 
305                 310                 315                 320 


Phe Asn Lys Asp His Cys Leu Ser Ser Thr Gln Arg Phe Phe Cys Pro 
                325                 330                 335     


Tyr Ser Asp Ala Lys Leu Leu Thr Ser Lys Ile Ser Ser Cys Leu Ser 
            340                 345                 350         


Gly Ile Arg Gly Asp Cys Ile Phe Ser Pro Val Val Gly Asn Phe Ala 
        355                 360                 365             


Thr Arg Phe Ile Ser Val Lys Gly Val Ile Ile Ala Asn Cys Lys Phe 
    370                 375                 380                 


Ile Arg Cys Thr Cys Leu Gln Pro Glu Gly Ile Ile Ser Gln Leu Asp 
385                 390                 395                 400 


Asp His Thr Leu Thr Val Ile Asp Leu Lys Leu Cys Asn Lys Leu Asp 
                405                 410                 415     


Leu Gly Leu Ile Gln Phe Asp Leu Gln Val Leu Ser Asn Ile Ser Tyr 
            420                 425                 430         


Glu Met Thr Leu Asn Thr Ser Gln Asn Gln Leu Ile Leu Thr Asp Pro 
        435                 440                 445             


Leu Asp Leu Ser Ser Glu Leu Gln Thr Met Asn Gln Ser Ile Asn Asn 
    450                 455                 460                 


Ala Ala Asn Phe Ile Glu Lys Ser Asn Ser Leu Leu Asn Ser Ser Thr 
465                 470                 475                 480 


Tyr Glu Phe Asn Arg Ser Val Ala Leu Leu Val Ala Leu Ile Leu Leu 
                485                 490                 495     


Ser Leu Thr Ile Leu Tyr Val Ile Val Leu Thr Cys Val Val Lys Leu 
            500                 505                 510         


Leu Val His Glu Val Ser Lys Asn Arg Arg His Ile Gln Asp Leu Glu 
        515                 520                 525             


Ser His His Lys 
    530         


<210>  439
<211>  580
<212>  PRT
<213>  Tuhoko pararubulavirus 1

<400>  439

Met Asp Ser Arg Ser Asp Ser Phe Thr Asp Ile Pro Leu Asp Asn Arg 
1               5                   10                  15      


Ile Glu Arg Thr Val Thr Ser Lys Lys Thr Trp Arg Ser Ile Phe Arg 
            20                  25                  30          


Val Thr Ala Ile Ile Leu Leu Ile Ile Cys Val Val Val Ser Ser Ile 
        35                  40                  45              


Ser Leu Asn Gln His Asn Asp Ala Pro Leu Asn Gly Ala Gly Asn Gln 
    50                  55                  60                  


Ala Thr Ser Gly Phe Met Asp Ala Ile Lys Ser Leu Glu Lys Leu Met 
65                  70                  75                  80  


Ser Gln Thr Ile Asn Glu Leu Asn Gln Val Val Met Thr Thr Ser Val 
                85                  90                  95      


Gln Leu Pro Asn Arg Ile Thr Lys Phe Gly Gln Asp Ile Leu Asp Gln 
            100                 105                 110         


Val Thr Gln Met Val Arg Gln Cys Asn Ala Val Cys Arg Gly Pro Gly 
        115                 120                 125             


Val Gly Pro Ser Ile Gln Asn Tyr Val Ile Gln Gly His Ala Pro Thr 
    130                 135                 140                 


Val Ser Phe Asp Pro Ile Ser Ala Glu Tyr Gln Lys Phe Val Phe Gly 
145                 150                 155                 160 


Ile Thr Glu Lys Thr Leu Ile Thr Ala Tyr His Asn Pro Trp Glu Cys 
                165                 170                 175     


Leu Arg Phe Pro Ser Gln His Leu Phe Asp Thr Thr Trp Cys Val Ser 
            180                 185                 190         


Tyr Gln Ile Leu Thr Gln Asn Cys Ser Asp His Gly Pro Arg Ile Thr 
        195                 200                 205             


Val Ile Gln Leu Gly Glu Ile Met Ile Ala Asn Asn Leu Ser Thr Val 
    210                 215                 220                 


Phe Arg Asp Pro Val Ile Lys Tyr Ile Arg His His Ile Trp Leu Arg 
225                 230                 235                 240 


Ser Cys Ser Val Val Ala Tyr Tyr Ser Gln Cys Thr Ile Phe Cys Thr 
                245                 250                 255     


Ser Thr Asn Lys Ser Glu Pro Ser Asp Tyr Ala Asp Thr Gly Tyr Glu 
            260                 265                 270         


Gln Leu Phe Leu Ala Thr Leu Gln Ser Asp Gly Thr Phe Thr Glu His 
        275                 280                 285             


Ser Met His Gly Val Asn Ile Val His Gln Trp Asn Ala Ile Tyr Gly 
    290                 295                 300                 


Gly Val Gly Asn Gly Val Ile Ile Gly Arg Asn Met Leu Ile Pro Leu 
305                 310                 315                 320 


Tyr Gly Gly Ile Asn Tyr Tyr Asp His Asn Thr Thr Ile Val Gln Thr 
                325                 330                 335     


Val Asp Leu Arg Pro Tyr Pro Ile Pro Asp Ser Cys Ser Gln Thr Asp 
            340                 345                 350         


Asn Tyr Gln Thr Asn Tyr Leu Pro Ser Met Phe Thr Asn Ser Tyr Tyr 
        355                 360                 365             


Gly Thr Asn Leu Val Val Ser Gly Tyr Leu Ser Cys Arg Leu Met Ala 
    370                 375                 380                 


Gly Thr Pro Thr Ser Cys Ser Ile Arg Val Ile Pro Ile Glu Asn Met 
385                 390                 395                 400 


Thr Met Gly Ser Glu Gly Gln Phe Tyr Leu Ile Asn Asn Gln Leu Tyr 
                405                 410                 415     


Tyr Tyr Lys Arg Ser Ser Asn Trp Ile Arg Asp Thr Gln Val Tyr Leu 
            420                 425                 430         


Leu Ser Tyr Ser Asp Lys Gly Asn Ile Ile Glu Ile Thr Ser Ala Glu 
        435                 440                 445             


Arg Tyr Ile Phe Lys Ser Val Thr Ser Pro Asp Glu Gly Asp Cys Val 
    450                 455                 460                 


Thr Asn His Gly Cys Pro Ser Asn Cys Ile Gly Gly Leu Phe Gln Ala 
465                 470                 475                 480 


Pro Trp Ile Leu Asn Asp Phe Lys Leu Cys Gly Ser Asn Ile Thr Cys 
                485                 490                 495     


Pro Lys Ile Val Thr Val Trp Ala Asp Gln Pro Asp Lys Arg Ser Asn 
            500                 505                 510         


Pro Met Leu Ser Ile Ala Glu Thr Asp Lys Leu Leu Leu His Lys Ser 
        515                 520                 525             


Tyr Ile Asn Tyr His Thr Ala Val Gly Tyr Ser Thr Val Leu Cys Phe 
    530                 535                 540                 


Asp Ser Pro Lys Leu Asn Leu Lys Thr Cys Val Val Leu Gln Glu Leu 
545                 550                 555                 560 


Met Ser Asp Asp Lys Leu Leu Ile Arg Ile Ser Tyr Ser Ile Val Ser 
                565                 570                 575     


Ile Met Val Glu 
            580 


<210>  440
<211>  588
<212>  PRT
<213>  Tuhoko pararubulavirus 2

<400>  440

Met Pro Pro Val Pro Thr Val Ser Gln Ser Ile Asp Glu Gly Ser Phe 
1               5                   10                  15      


Thr Asp Ile Pro Leu Ser Pro Asp Asp Ile Lys His Pro Leu Ser Lys 
            20                  25                  30          


Lys Thr Cys Arg Lys Leu Phe Arg Ile Val Thr Leu Ile Gly Val Gly 
        35                  40                  45              


Leu Ile Ser Ile Leu Thr Ile Ile Ser Leu Ala Gln Gln Thr Gly Ile 
    50                  55                  60                  


Leu Arg Lys Val Asp Ser Ser Asp Phe Gln Ser Tyr Val Gln Glu Ser 
65                  70                  75                  80  


Phe Lys Gln Val Leu Asn Leu Met Lys Gln Phe Ser Ser Asn Leu Asn 
                85                  90                  95      


Ser Leu Ile Glu Ile Thr Ser Val Thr Leu Pro Phe Arg Ile Asp Gln 
            100                 105                 110         


Phe Gly Thr Asp Ile Lys Thr Gln Val Ala Gln Leu Val Arg Gln Cys 
        115                 120                 125             


Asn Ala Val Cys Arg Gly Pro Ile Lys Gly Pro Thr Thr Gln Asn Ile 
    130                 135                 140                 


Val Tyr Pro Ala Leu Tyr Glu Thr Ser Leu Asn Lys Thr Leu Glu Thr 
145                 150                 155                 160 


Lys Asn Val Arg Ile Gln Glu Val Arg Gln Glu Val Asp Pro Val Pro 
                165                 170                 175     


Gly Pro Gly Leu Ser Asn Gly Cys Thr Arg Asn Pro Ser Phe Ser Val 
            180                 185                 190         


Tyr His Gly Val Trp Cys Tyr Thr His Ala Thr Ser Ile Gly Asn Cys 
        195                 200                 205             


Asn Gly Ser Leu Gly Thr Ser Gln Leu Phe Arg Ile Gly Asn Val Leu 
    210                 215                 220                 


Glu Gly Asp Gly Gly Ala Pro Tyr His Lys Ser Leu Ala Thr His Leu 
225                 230                 235                 240 


Leu Thr Thr Arg Asn Val Ser Arg Gln Cys Ser Ala Thr Ala Ser Tyr 
                245                 250                 255     


Tyr Gly Cys Tyr Phe Ile Cys Ser Glu Pro Val Leu Thr Glu Arg Asp 
            260                 265                 270         


Asp Tyr Glu Thr Pro Gly Ile Glu Pro Ile Thr Ile Phe Arg Leu Asp 
        275                 280                 285             


Pro Asp Gly Asn Trp Val Val Phe Pro Asn Ile Asn Arg Phe Thr Glu 
    290                 295                 300                 


Tyr Ser Leu Lys Ala Leu Tyr Pro Gly Ile Gly Ser Gly Val Leu Phe 
305                 310                 315                 320 


Gln Gly Lys Leu Ile Phe Pro Met Tyr Gly Gly Ile Asp Lys Glu Arg 
                325                 330                 335     


Leu Ser Ala Leu Gly Leu Gly Asn Ile Gly Leu Ile Glu Arg Arg Met 
            340                 345                 350         


Ala Asp Thr Cys Asn His Thr Glu Lys Glu Leu Gly Arg Ser Phe Pro 
        355                 360                 365             


Gly Ala Phe Ser Ser Pro Tyr Tyr His Asp Ala Val Met Leu Asn Phe 
    370                 375                 380                 


Leu Leu Ile Cys Glu Met Ile Glu Asn Leu Pro Gly Asp Cys Asp Leu 
385                 390                 395                 400 


Gln Ile Leu Asn Pro Thr Asn Met Ser Met Gly Ser Glu Ser Gln Leu 
                405                 410                 415     


Ser Val Leu Asp Asn Glu Leu Phe Leu Tyr Gln Arg Ser Ala Ser Trp 
            420                 425                 430         


Trp Pro Tyr Thr Leu Ile Tyr Arg Leu Asn Met Arg Tyr Thr Gly Lys 
        435                 440                 445             


Tyr Leu Lys Pro Lys Ser Ile Ile Pro Met Val Ile Lys Ser Asn Thr 
    450                 455                 460                 


Arg Pro Gly Tyr Glu Gly Cys Asn His Glu Arg Val Cys Pro Lys Val 
465                 470                 475                 480 


Cys Val Thr Gly Val Phe Gln Ala Pro Trp Ile Leu Ser Ile Gly Arg 
                485                 490                 495     


Asp His Lys Glu Arg Val Ser Asn Val Thr Tyr Met Val Ala Trp Ser 
            500                 505                 510         


Met Asp Lys Ser Asp Arg Thr Tyr Pro Ala Val Ser Val Cys Gly Ser 
        515                 520                 525             


Asp Thr Cys Lys Leu Thr Val Pro Leu Gly Asp Ser Lys Val His Ser 
    530                 535                 540                 


Ala Tyr Ser Val Thr Arg Cys Tyr Leu Ser Arg Asp His Met Ser Ala 
545                 550                 555                 560 


Tyr Cys Leu Val Ile Phe Glu Leu Asp Ala Arg Pro Trp Ala Glu Met 
                565                 570                 575     


Arg Ile Gln Ser Phe Leu Tyr Lys Leu Ile Leu Thr 
            580                 585             


<210>  441
<211>  539
<212>  PRT
<213>  Tuhoko pararubulavirus 2

<400>  441

Met Ala Pro Cys Val Leu Phe Leu Ser Ser Leu Leu Leu Ile Ser Thr 
1               5                   10                  15      


Ile Ser Pro Ser His Gly Ile Asn Gln Pro Ala Leu Arg Arg Ile Gly 
            20                  25                  30          


Ala Ile Val Ser Ser Val Lys Gln Leu Lys Phe Tyr Ser Lys Thr Lys 
        35                  40                  45              


Pro Asn Tyr Ile Ile Val Lys Leu Leu Pro Thr Ile Asn Leu Ser Lys 
    50                  55                  60                  


Ser Asn Cys Asn Leu Thr Ser Ile Asn Arg Tyr Lys Glu Ser Val Ile 
65                  70                  75                  80  


Glu Ile Ile Lys Pro Leu Ala Asp Asn Ile Asp Asn Leu Asn Gln Lys 
                85                  90                  95      


Leu Leu Pro Lys Asn Arg Arg Lys Arg Met Ala Gly Val Ala Ile Gly 
            100                 105                 110         


Leu Ala Ala Leu Gly Val Ala Ala Ala Ala Gln Ala Thr Ala Ala Val 
        115                 120                 125             


Ala Leu Val Glu Ala Arg Lys Asn Thr Gln Met Ile Gln Ser Leu Ala 
    130                 135                 140                 


Asp Ser Ile Gln Asp Thr Asn Ala Ala Val Gln Ala Val Asn Ile Gly 
145                 150                 155                 160 


Leu Gln Asn Ser Ala Val Ala Ile Gln Ala Ile Gln Asn Gln Ile Asn 
                165                 170                 175     


Asn Val Ile Asn Pro Ala Leu Asp Arg Leu Asn Cys Glu Val Leu Asp 
            180                 185                 190         


Ala Gln Ile Ala Ser Ile Leu Asn Leu Tyr Leu Ile Lys Ser Val Thr 
        195                 200                 205             


Ile Phe Gln Asn Gln Leu Thr Asn Pro Ala Leu Gln Gln Leu Ser Ile 
    210                 215                 220                 


Gln Met Leu Ser Ile Val Met Gln Asp Thr Ala Lys Ile Leu Gly Asn 
225                 230                 235                 240 


Phe Thr Ile Gly Asp Lys Phe Asp Gln His Asp Leu Leu Gly Ser Gly 
                245                 250                 255     


Leu Ile Thr Gly Gln Val Val Gly Val Asn Leu Thr Asn Leu Gln Leu 
            260                 265                 270         


Ile Ile Ala Ala Phe Ile Pro Ser Ile Ala Pro Leu Pro Gln Ala Tyr 
        275                 280                 285             


Ile Ile Asp Leu Ile Ser Ile Thr Ile Ser Val Asn Asp Thr Glu Ala 
    290                 295                 300                 


Val Ile Gln Ile Pro Glu Arg Ile Met Glu His Gly Ser Ser Ile Tyr 
305                 310                 315                 320 


Gln Phe Gly Gly Lys Gln Cys Val Tyr Gly Gln Phe Ser Ala Tyr Cys 
                325                 330                 335     


Pro Phe Ser Asp Ala Val Leu Met Thr Gln Asp Leu Gln Leu Cys Met 
            340                 345                 350         


Lys Gly Asn Ile Glu His Cys Ile Phe Ser Ser Val Leu Gly Ser Phe 
        355                 360                 365             


Pro Asn Arg Phe Ala Ser Val Asp Gly Val Phe Tyr Ala Asn Cys Lys 
    370                 375                 380                 


Tyr Met Ser Cys Ala Cys Ser Asp Pro Leu Gln Val Ile His Gln Asp 
385                 390                 395                 400 


Asp Ser Val Asn Leu Met Val Ile Asp Ser Ser Val Cys Arg Ser Leu 
                405                 410                 415     


Thr Leu Gly His Val Thr Phe Pro Ile Ile Ala Phe Ser Asn Val Ser 
            420                 425                 430         


Tyr Gln Met Lys Thr Asn Ile Ser Ile Glu Gln Met Ile Val Thr Ser 
        435                 440                 445             


Pro Leu Asp Leu Ser Thr Glu Leu Lys Gln Ile Asn Asn Ser Val Asn 
    450                 455                 460                 


Ile Ala Asn Thr Phe Leu Asp Ser Ser Asn Arg Ala Leu Lys Thr Ser 
465                 470                 475                 480 


Ile Phe Gly Thr Ser Ser Gln Ile Ile Leu Ile Val Leu Leu Ile Phe 
                485                 490                 495     


Thr Cys Leu Leu Ile Leu Tyr Val Ile Phe Leu Thr Tyr Ile Ile Lys 
            500                 505                 510         


Ile Leu Ile Lys Glu Val Lys Arg Leu Arg Asp Gly Asn Ser Arg Thr 
        515                 520                 525             


Gly Ser Lys Leu Ser Phe Ile Asn Pro Asp Val 
    530                 535                 


<210>  442
<211>  582
<212>  PRT
<213>  Tuhoko pararubulavirus 3

<400>  442

Met His Asn Arg Thr Gln Ser Val Ser Ser Ile Asp Thr Ser Ser Asp 
1               5                   10                  15      


Val Tyr Leu Pro Arg Arg Lys Lys Ala Val Thr Lys Phe Thr Phe Lys 
            20                  25                  30          


Lys Ile Phe Arg Val Leu Ile Leu Thr Leu Leu Leu Ser Ile Ile Ile 
        35                  40                  45              


Ile Ile Ala Val Ile Phe Pro Lys Ile Asp His Ile Arg Glu Thr Cys 
    50                  55                  60                  


Asp Asn Ser Gln Ile Leu Glu Thr Ile Thr Asn Gln Asn Ser Glu Ile 
65                  70                  75                  80  


Lys Asn Leu Ile Asn Ser Ala Ile Thr Asn Leu Asn Val Leu Leu Thr 
                85                  90                  95      


Ser Thr Thr Val Asp Leu Pro Ile Lys Leu Asn Asn Phe Gly Lys Ser 
            100                 105                 110         


Ile Val Asp Gln Val Thr Met Met Val Arg Gln Cys Asn Ala Val Cys 
        115                 120                 125             


Arg Gly Pro Gly Asp Arg Pro Thr Gln Asn Ile Glu Leu Phe Lys Gly 
    130                 135                 140                 


Leu Tyr His Thr Ser Pro Pro Ser Asn Thr Ser Thr Lys Leu Ser Met 
145                 150                 155                 160 


Ile Thr Glu Ala Ser Asn Pro Asp Asp Ile Val Pro Arg Pro Gly Lys 
                165                 170                 175     


Leu Leu Gly Cys Thr Arg Phe Pro Ser Phe Ser Val His Tyr Gly Leu 
            180                 185                 190         


Trp Cys Tyr Gly His Met Ala Ser Thr Gly Asn Cys Ser Gly Ser Ser 
        195                 200                 205             


Pro Ser Val Gln Ile Ile Arg Ile Gly Ser Ile Gly Thr Asn Lys Asp 
    210                 215                 220                 


Gly Thr Pro Lys Tyr Val Ile Ile Ala Ser Ala Ser Leu Pro Glu Thr 
225                 230                 235                 240 


Thr Arg Leu Tyr His Cys Ser Val Thr Met Thr Ser Ile Gly Cys Tyr 
                245                 250                 255     


Ile Leu Cys Thr Thr Pro Ser Val Ser Glu Thr Asp Asp Tyr Ser Thr 
            260                 265                 270         


Met Gly Ile Glu Lys Met Ser Ile Ser Phe Leu Ser Leu Asp Gly Tyr 
        275                 280                 285             


Leu Thr Gln Leu Gly Gln Pro Thr Gly Leu Asp Asn Gln Asn Leu Tyr 
    290                 295                 300                 


Ala Leu Tyr Pro Gly Pro Gly Ser Gly Val Ile Phe Arg Asp Phe Leu 
305                 310                 315                 320 


Ile Phe Pro Met Met Gly Gly Ile Arg Leu Met Asp Ala Gln Lys Met 
                325                 330                 335     


Leu Asn Arg Asn Ile Thr Tyr Arg Gly Phe Pro Pro Ser Glu Thr Cys 
            340                 345                 350         


Thr Glu Ser Glu Leu Lys Leu Lys Gln Glu Val Ala Asn Met Leu Thr 
        355                 360                 365             


Ser Pro Tyr Tyr Gly Glu Val Leu Val Leu Asn Phe Leu Tyr Val Cys 
    370                 375                 380                 


Ser Leu Leu Asp Asn Ile Pro Gly Asp Cys Ser Val Gln Leu Ile Pro 
385                 390                 395                 400 


Pro Asp Asn Met Thr Leu Gly Ala Glu Ser Arg Leu Tyr Val Leu Asn 
                405                 410                 415     


Gly Ser Leu Ile Met Tyr Lys Arg Gly Ser Ser Trp Trp Pro Tyr Thr 
            420                 425                 430         


Glu Leu Tyr Gln Ile Asn Tyr Arg Val Asn Asn Arg Ala Phe Arg Val 
        435                 440                 445             


Arg Glu Ser Val Arg Ile Asn Thr Thr Ser Thr Ser Arg Pro Gly Val 
    450                 455                 460                 


Gln Gly Cys Asn Leu Glu Lys Val Cys Pro Lys Val Cys Val Ser Gly 
465                 470                 475                 480 


Ile Tyr Gln Ser Pro Gly Ile Ile Ser Ala Pro Val Asn Pro Thr Arg 
                485                 490                 495     


Gln Glu Glu Gly Leu Leu Tyr Phe Leu Val Trp Thr Ser Ser Met Ser 
            500                 505                 510         


Ser Arg Thr Gly Pro Leu Ser Ser Leu Cys Asp His Ser Thr Cys Arg 
        515                 520                 525             


Ile Thr Tyr Pro Ile Gly Asp Asp Thr Ile Phe Ile Gly Tyr Thr Asp 
    530                 535                 540                 


Ser Ser Cys Phe Met Ser Ser Ile Lys Glu Gly Ile Tyr Cys Ile Ala 
545                 550                 555                 560 


Phe Leu Glu Leu Asp Asn Gln Pro Tyr Ser Met Met Ala Ile Arg Ser 
                565                 570                 575     


Leu Ser Tyr Ile Ile Asn 
            580         


<210>  443
<211>  537
<212>  PRT
<213>  Tuhoko pararubulavirus 3

<400>  443

Met Leu Trp Leu Thr Ile Leu Ile Ala Leu Val Gly Asn His Glu Ser 
1               5                   10                  15      


Thr Cys Met Asn Ile Asn Phe Leu Gln Ser Leu Gly Gln Ile Asn Ser 
            20                  25                  30          


Gln Lys Arg Phe Leu Asn Phe Tyr Thr Gln Gln Pro Pro Ser Tyr Met 
        35                  40                  45              


Val Ile Arg Leu Val Pro Thr Leu Gln Leu Ser Ala Asn Asn Cys Thr 
    50                  55                  60                  


Leu Gly Ser Ile Val Arg Tyr Arg Asn Ala Ile Lys Glu Leu Ile Gln 
65                  70                  75                  80  


Pro Met Asp Glu Asn Leu Arg Trp Leu Ser Ser Asn Leu Ile Pro Gln 
                85                  90                  95      


Arg Arg Gly Lys Arg Phe Ala Gly Val Ala Val Gly Leu Ala Ala Leu 
            100                 105                 110         


Gly Val Ala Val Ala Ala Gln Ala Thr Ala Ala Val Ala Leu Val Glu 
        115                 120                 125             


Ala Arg Ala Asn Ala Glu Lys Ile Ala Ser Met Ser Gln Ser Ile Gln 
    130                 135                 140                 


Glu Thr Asn Lys Ala Val Thr Ser Leu Ser Gln Ala Val Ser Ala Ser 
145                 150                 155                 160 


Gly Ile Ala Ile Gln Ala Ile Gln Asn Glu Ile Asn Asn Val Ile His 
                165                 170                 175     


Pro Ile Leu Asn Gln Val Gln Cys Asp Val Leu Asp Ala Arg Val Gly 
            180                 185                 190         


Asn Ile Leu Asn Leu Tyr Leu Ile Lys Val Thr Thr Ile Phe Gln Asn 
        195                 200                 205             


Gln Leu Thr Asn Pro Ala Leu Gln Arg Leu Ser Thr Gln Ala Leu Ser 
    210                 215                 220                 


Met Leu Met Gln Ser Thr Ser Ser Tyr Leu Arg Asn Leu Ser Ser Ser 
225                 230                 235                 240 


Glu Ser Ala Ile Asn Ala Asp Leu Ser Met Thr Asn Leu Ile Glu Ala 
                245                 250                 255     


Gln Ile Val Gly Ile Asn Met Thr Asn Leu Gln Leu Val Leu Ala Val 
            260                 265                 270         


Phe Ile Pro Ser Ile Ala Arg Leu Asn Gly Ala Leu Leu Tyr Asp Phe 
        275                 280                 285             


Ile Ser Ile Thr Ile Ser Ser Asn Gln Thr Glu Val Met Leu Gln Ile 
    290                 295                 300                 


Pro His Arg Val Leu Glu Ile Gly Asn Ser Leu Tyr Thr Phe Glu Gly 
305                 310                 315                 320 


Thr Gln Cys Glu Met Thr Lys Leu Asn Ala Tyr Cys Leu Tyr Ser Asp 
                325                 330                 335     


Ala Ile Pro Val Thr Glu Ser Leu Arg Asp Cys Met Asn Gly Leu Phe 
            340                 345                 350         


Ser Gln Cys Gly Phe Val Arg Ile Ile Gly Ser Phe Ala Asn Arg Phe 
        355                 360                 365             


Ala Ser Val Asn Gly Val Ile Tyr Ala Asn Cys Lys His Leu Thr Cys 
    370                 375                 380                 


Ser Cys Leu Gln Pro Asp Glu Ile Ile Thr Gln Asp Thr Asn Val Pro 
385                 390                 395                 400 


Leu Thr Ile Ile Asp Thr Lys Arg Cys Thr Lys Ile Ser Leu Gly His 
                405                 410                 415     


Leu Thr Phe Thr Ile Arg Glu Tyr Ala Asn Val Thr Tyr Ser Leu Arg 
            420                 425                 430         


Thr Glu Ile Ala Asn Ser Gln Ile Thr Val Val Ser Pro Leu Asp Leu 
        435                 440                 445             


Ser Ser Gln Leu Thr Thr Ile Asn Asn Ser Leu Ala Asp Ala Thr Asn 
    450                 455                 460                 


His Ile Met Asn Ser Asp Arg Ile Leu Asp Arg Leu Asn Ser Gly Leu 
465                 470                 475                 480 


Tyr Ser Lys Trp Val Ile Ile Phe Leu Ile Cys Ala Ser Ile Val Ser 
                485                 490                 495     


Leu Ile Gly Leu Val Phe Leu Gly Phe Leu Ile Arg Gly Leu Ile Leu 
            500                 505                 510         


Glu Leu Arg Ser Lys His Arg Ser Asn Leu Asn Lys Ala Ser Thr Tyr 
        515                 520                 525             


Ser Ile Asp Ser Ser Ile Gly Leu Thr 
    530                 535         


<210>  444
<211>  536
<212>  PRT
<213>  Cynoglossus cynoglossusvirus

<400>  444

Met Ser Gln Leu Phe Leu Leu Tyr Val Leu Leu Gly Cys Thr Gly Ala 
1               5                   10                  15      


Thr Arg Leu Ile Thr Thr Leu Met Lys Ala Gly Thr Ile Leu Asp Gln 
            20                  25                  30          


Ile Gly Pro Ile Ser Val Glu Arg Pro Asp Val Ser Phe Gln Leu Leu 
        35                  40                  45              


Val Pro Ile Ile Pro Arg Asn Gly Phe Lys Pro Thr Ala Cys Gly Gly 
    50                  55                  60                  


Asp Ile Leu Met Lys Phe Met Gln Asp Val Arg Ser Thr Leu Leu Pro 
65                  70                  75                  80  


Leu Glu Gln Ile Asn Ala Leu Lys Lys Asp Leu Met Thr Ser Arg Asp 
                85                  90                  95      


Gln Lys Phe Val Gly Ala Ile Ile Gly Thr Ala Ala Met Gly Val Ala 
            100                 105                 110         


Val Gly Ala Ser Val Thr Ala Gly Leu Ala Leu Asp His Ala Tyr Lys 
        115                 120                 125             


Asn Arg Arg Asp Ile Asp Gln Leu His Asn Ala Met Ser Asn Ser Phe 
    130                 135                 140                 


Asp Ala Leu Glu Gln Leu Gln Asp Ala Thr Lys Gly Leu Ala Val Ile 
145                 150                 155                 160 


Ile Lys Asp Ile Thr Asn Thr Ile Asn Arg Asp Ile Ile Pro Ala Ile 
                165                 170                 175     


Asn Thr Val Asn Cys Glu Leu Ser Lys Val Ala Leu Arg Gly Gln Leu 
            180                 185                 190         


Ala Ala Ile Phe Gln Lys Trp Leu Thr Ile Tyr Ser Pro Ile Leu Glu 
        195                 200                 205             


Ala Pro Leu Thr Ser His Lys Ser Ala Leu Leu Thr Gly Thr Leu Leu 
    210                 215                 220                 


Leu Asp Ala Ile Asn Ala Gly Leu Ser Leu Gln Thr Thr Thr Asp Gln 
225                 230                 235                 240 


Met Met Thr Tyr Ala Met Asn Gly Met Ile Ser Val Gln Leu Met Glu 
                245                 250                 255     


Tyr Asn Ala Thr Thr Ala Ser Val Leu Leu Leu Val Ser Val Asn Ala 
            260                 265                 270         


Arg Ser Glu Thr Pro Gly Tyr Lys Ala Tyr Arg Thr His Ser Ile Met 
        275                 280                 285             


Ile Ala Val Gly Asn Pro Ala Arg Tyr Ser Val Ile Ser Leu Pro Ser 
    290                 295                 300                 


His Met Ala Thr Asn Gly Ile Asn Trp Tyr Ser Val Ser Asp Thr Cys 
305                 310                 315                 320 


Thr Gln Lys Ser Thr Gly Leu Val Cys Thr Gly Ser Ala Leu Ser Pro 
                325                 330                 335     


Phe Asn Glu Asp Leu Asp Lys Cys Val Gln Gly Asp Thr Asn Arg Cys 
            340                 345                 350         


Met Trp Thr Ser Ser Gln Gly Gly Ser Ser Phe Ile Leu Leu Lys Ser 
        355                 360                 365             


Gly Ile Leu Ala Asp Cys Asn Thr Leu Ile Cys Thr Cys Asn Ser Ile 
    370                 375                 380                 


Ala Ile Ser Gly Leu Arg Tyr Ile Ser Thr Asp Cys Pro Thr Pro Met 
385                 390                 395                 400 


Ile Ser Gly Thr Gln Tyr Lys Ile Gln Ala Thr Asp Leu Gly Tyr Phe 
                405                 410                 415     


Val Ser Asn Thr Ser Ile Ser Tyr Asp Pro Val Pro Pro Val Asn Ile 
            420                 425                 430         


Ser Phe Ile Asp Val Thr Ser Met Gln Ser Ile Gln Lys Ala Leu Asn 
        435                 440                 445             


Arg Ser Asp Arg Ala Leu Gln Met Ala Arg Asp Ala Leu Ser Arg Val 
    450                 455                 460                 


Ser Asn Gly Ser Gly Met Ser Ile Glu Thr Met Val Ala Ile Ala Cys 
465                 470                 475                 480 


Gly Val Thr Gly Val Leu Val Leu Leu Ile Ile Gly Leu Ile Gly Leu 
                485                 490                 495     


Ile Tyr Ala Ala Cys Lys Arg Asp Gly Thr Ile Met Glu Arg Phe Lys 
            500                 505                 510         


His Pro Lys Ala Asp Ala Ala Tyr Asp Asn Pro Met Gly Pro Thr Arg 
        515                 520                 525             


Thr Ile Asn Ile Ser Asp Leu Val 
    530                 535     


<210>  445
<211>  428
<212>  PRT
<213>  Cynoglossus cynoglossusvirus

<400>  445

Met Thr Asn Arg Ile Phe Leu Leu Phe Leu Ile Leu Gly Leu Leu Thr 
1               5                   10                  15      


Thr Trp Thr Thr Ile Thr Ile Gln Leu Ile Thr Leu Tyr Asn Trp Glu 
            20                  25                  30          


Asn Glu Ser Thr Asn Thr Thr Thr Thr Lys Ala Glu Pro Pro Gln Cys 
        35                  40                  45              


Ala Thr Ser Ala Asp Ile Ile Arg Leu Glu His Ala Val Ile Asn Gln 
    50                  55                  60                  


Leu Leu Pro Asn Leu Gly Ser Ile Ser Gln Gly Val Thr Gln Leu Thr 
65                  70                  75                  80  


Ser Arg Pro Gly Leu Cys Tyr Gln Ala His Gly Gln Phe Ser Lys Tyr 
                85                  90                  95      


Thr Gln Leu Asn Phe Asp Asn Tyr Gly Thr Ser Thr Val Val Ile Pro 
            100                 105                 110         


Asn Trp Arg Pro Asn Leu Arg Cys Val Glu Ala Glu Arg Leu Glu Arg 
        115                 120                 125             


Thr Gly Ala Ile Ile Val Gln Asn Thr Thr His Ala Phe Met Arg Thr 
    130                 135                 140                 


Asp Asn Phe Leu Ala Pro Thr Ser Ile Trp Thr Ile Ala Ser Gly Gly 
145                 150                 155                 160 


Pro Asp His Val Thr Ile Lys Ile Leu Val Val Thr Ser Gln Val Asp 
                165                 170                 175     


Leu Arg Gln Tyr Tyr Gly Pro Tyr Ile Glu Leu Gly Ala Leu Ser Thr 
            180                 185                 190         


Arg Ser Val Asp Thr Val Phe Lys Asp Ile Tyr Ser Trp Phe Phe Gly 
        195                 200                 205             


Phe Asn Ser Gly Tyr Ala Cys Leu Phe Met Thr Arg Lys Asp Asp Arg 
    210                 215                 220                 


Thr Ser His Val Glu Cys Phe Val Ala Asn Val Ser Thr Pro Asn Tyr 
225                 230                 235                 240 


Ala Gly Ala Leu Ser Leu Pro Asn Asn Thr Ile Ile Leu Pro Gly Ser 
                245                 250                 255     


Ser Ser Trp Val Asn Ser Ser Thr Val Leu Leu Gly Thr Lys Thr Thr 
            260                 265                 270         


Pro Asn Asn Cys Glu Ala Pro Thr Arg Ser Met Tyr Gln Glu His Asp 
        275                 280                 285             


Gly Ile Cys Tyr Thr Val Ile His Tyr Asp Trp Lys Asp Asn Arg Leu 
    290                 295                 300                 


Ala Asn Ser Arg Thr Gly Tyr Ile Met Ile Gln Arg His Trp Glu Asp 
305                 310                 315                 320 


Ala Ser Ser Lys Ser Leu Phe Arg Phe Ser Ser Asn Gly Cys Arg Ile 
                325                 330                 335     


Met Asn Asp Gln His Ile Asn Leu Pro Val Trp Trp Gly Thr Leu Ser 
            340                 345                 350         


Asn Arg Ala Tyr Val Ser Cys Thr Gly Ala Asp Glu Ser Gln Ser Cys 
        355                 360                 365             


Ile Tyr His Thr Thr Ser Asn Gln Asn Ile Glu Gly His Tyr Pro Ala 
    370                 375                 380                 


Gly Leu Ser Gly Val Thr Val Phe Arg Met Gln Gly Arg Thr His Gly 
385                 390                 395                 400 


Leu Lys Asn Gly Cys Ser Ile Ser Asp Lys Leu Ile Ala Ser Gly Ser 
                405                 410                 415     


Gly Thr Asp Met Gln Cys Phe Leu Asp Gln Pro Arg 
            420                 425             


<210>  446
<211>  513
<212>  PRT
<213>  Hoplichthys hoplichthysvirus

<400>  446

Met Phe Lys Phe Thr Leu Val Leu Val Val Cys Leu Ser Leu Val Ser 
1               5                   10                  15      


Gly Asp Phe Leu Arg Asn Gly Val Leu Pro Ile Arg Arg Gly Glu Val 
            20                  25                  30          


Arg Ala Glu Val Arg Val Gly Glu Ile Met Ile Tyr Glu Pro Tyr Ser 
        35                  40                  45              


Ala Leu Ile Pro Ser Gly Asp Thr Cys Leu Leu Gln Ile Leu Ala Glu 
    50                  55                  60                  


Val Asn Ala Gln Ala Asp Lys Ile Phe Pro Ser Ile Asn Phe Pro Asn 
65                  70                  75                  80  


Thr Thr Gly Ser Asn Asn Lys Phe Ile Gly Leu Val Leu Ala Gly Ala 
                85                  90                  95      


Ala Met Gly Val Ala Ser Gly Ala Leu Ala Thr Gly Ile Ala Ala Thr 
            100                 105                 110         


Ile Met Ala Thr Ser Asn Lys Lys His Ile Ser Glu Asn Arg Asn Ala 
        115                 120                 125             


Ile Asn Thr Leu Arg Asp Glu Asn Ile Ala Leu Lys Ala Gly Leu Asp 
    130                 135                 140                 


Leu Ala Ser Ser Ala Leu Asp Glu Val Ser Met Val Ile Gly Ser Ile 
145                 150                 155                 160 


Gln Gly Tyr Ile Asn Asn Asp Leu Ile Pro Val Met Ala Asn Met Ser 
                165                 170                 175     


Cys Glu Ile Lys Lys Asn Thr Phe Arg Thr Arg Leu Leu Ala Tyr Trp 
            180                 185                 190         


Leu Ser Leu Val Ser Lys Tyr Gln Asn Leu Ile Ala Asn Pro Trp Ser 
        195                 200                 205             


Glu Glu Pro Ser Phe Ser Glu Glu Gln Arg Ile Lys Asn Asp Ala Ser 
    210                 215                 220                 


Ile Ala Ala Leu Val Thr Ser Lys Tyr Gly Ile Pro Ala Thr Glu Phe 
225                 230                 235                 240 


Lys Gly Pro Asp Ile Arg Ile Arg Ile Ser Leu Ile Glu Ser Lys Asp 
                245                 250                 255     


Arg Ile Leu Leu Leu Met Ala Ser Ile Tyr Arg Thr Gln Leu Thr Gly 
            260                 265                 270         


Arg Asn Leu Val His Leu Pro Arg Ile Pro Leu Ser Asp Thr Asn Gly 
        275                 280                 285             


Gly Ser Val Ile Ser Asn Trp Pro Asn Tyr Val Val Cys Glu Gly Thr 
    290                 295                 300                 


Ser Thr Ser Asp Cys Tyr Thr Leu Ser Glu Thr Cys Thr Ile Glu Asn 
305                 310                 315                 320 


Glu Ser Ala Phe Cys Thr Ile Ile Asp Val Asp Ser Pro Ile Asn Leu 
                325                 330                 335     


Thr Cys Asp Glu Asp Cys Gly Tyr Val Ser Ser Pro Thr Ser Leu Ala 
            340                 345                 350         


Phe Met Gly Asp Gly Glu Gly Gly Ala Ile Val Asn Cys Ala Leu Ile 
        355                 360                 365             


Ser Cys Arg Cys Asp Gly Arg Asn Phe Ile Gly Met Gln His Phe Leu 
    370                 375                 380                 


Glu Gly Ser Cys Ser Val Leu Leu Leu Lys Gly Thr Ile Ala Leu Arg 
385                 390                 395                 400 


Leu Arg Glu Leu Gly Glu Ile Ile Lys Asp Pro Val Val Ile Asn Ser 
                405                 410                 415     


Ser Ser Gly His Leu Pro Pro Ala Ile Asn Leu Gln Asn Asn Ile Ser 
            420                 425                 430         


Asp Leu Ala Lys Glu Met Lys Val Val Thr Lys Asp Val Gly Asp Trp 
        435                 440                 445             


Gly Ala Leu Gly Gly Leu Ser Ala Thr Pro Tyr Pro Phe Thr Ile Trp 
    450                 455                 460                 


Leu Val Ile Leu Thr Val Met Leu Leu Ser Leu Ile Val Phe Val Ile 
465                 470                 475                 480 


Val Leu Met Val Lys Met Arg Arg Glu Leu Lys Arg Leu Asn Ser Ala 
                485                 490                 495     


Asn Thr Ser Ser Asn Phe His Leu Ser Met Ile Ser Glu Ser Ser Asp 
            500                 505                 510         


Asn 
    


<210>  447
<211>  537
<212>  PRT
<213>  Avian metapneumovirus

<400>  447

Met Ser Trp Lys Val Val Leu Leu Leu Val Leu Leu Ala Thr Pro Thr 
1               5                   10                  15      


Gly Gly Leu Glu Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Val Thr 
            20                  25                  30          


Arg Gly Tyr Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe 
        35                  40                  45              


Thr Leu Glu Val Gly Asp Val Glu Asn Leu Thr Cys Thr Asp Gly Pro 
    50                  55                  60                  


Ser Leu Ile Arg Thr Glu Leu Glu Leu Thr Lys Asn Ala Leu Glu Glu 
65                  70                  75                  80  


Leu Lys Thr Val Ser Ala Asp Gln Leu Ala Lys Glu Ala Arg Ile Met 
                85                  90                  95      


Ser Pro Arg Lys Ala Arg Phe Val Leu Gly Ala Ile Ala Leu Gly Val 
            100                 105                 110         


Ala Thr Ala Ala Ala Val Thr Ala Gly Val Ala Ile Ala Lys Thr Ile 
        115                 120                 125             


Arg Leu Glu Gly Glu Val Ala Ala Ile Lys Gly Ala Leu Arg Lys Thr 
    130                 135                 140                 


Asn Glu Ala Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Thr 
145                 150                 155                 160 


Ala Val Asn Asp Leu Lys Asp Phe Ile Ser Lys Lys Leu Thr Pro Ala 
                165                 170                 175     


Ile Asn Lys Asn Lys Cys Asp Ile Ser Asp Leu Lys Met Ala Val Ser 
            180                 185                 190         


Phe Gly Gln Tyr Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser 
        195                 200                 205             


Asp Asn Ala Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp 
    210                 215                 220                 


Ala Glu Leu Val Arg Ala Val Ser Asn Met Pro Thr Ser Ser Gly Gln 
225                 230                 235                 240 


Ile Asn Leu Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe 
                245                 250                 255     


Gly Ile Leu Ile Gly Val Tyr Gly Ser Ser Val Val Tyr Met Val Gln 
            260                 265                 270         


Leu Pro Ile Phe Gly Val Ile Asp Thr Pro Cys Trp Lys Val Lys Ala 
        275                 280                 285             


Ala Pro Leu Cys Ser Gly Lys Asp Gly Ser Tyr Ala Cys Leu Leu Arg 
    290                 295                 300                 


Glu Asp Gln Gly Trp Tyr Cys Gln Asn Ala Gly Ser Thr Val Tyr Tyr 
305                 310                 315                 320 


Pro Asn Glu Glu Asp Cys Glu Val Arg Ser Asp His Val Phe Cys Asp 
                325                 330                 335     


Thr Ala Ala Gly Ile Asn Val Ala Lys Glu Ser Glu Glu Cys Asn Arg 
            340                 345                 350         


Asn Ile Ser Thr Thr Lys Tyr Pro Cys Lys Val Ser Thr Gly Arg His 
        355                 360                 365             


Pro Ile Ser Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys 
    370                 375                 380                 


Tyr Asp Gly Val Ser Cys Ser Ile Gly Ser Asn Lys Val Gly Ile Ile 
385                 390                 395                 400 


Arg Pro Leu Gly Lys Gly Cys Ser Tyr Ile Ser Asn Gln Asp Ala Asp 
                405                 410                 415     


Thr Val Thr Ile Asp Asn Pro Val Tyr Gln Leu Ser Lys Val Glu Gly 
            420                 425                 430         


Glu Gln His Thr Ile Lys Gly Lys Pro Val Ser Ser Asn Phe Asp Pro 
        435                 440                 445             


Ile Glu Phe Pro Glu Asp Gln Phe Asn Ile Ala Leu Asp Gln Val Phe 
    450                 455                 460                 


Glu Ser Val Glu Lys Ser Lys Asn Leu Ile Asp Gln Ser Asn Lys Ile 
465                 470                 475                 480 


Leu Asp Ser Thr Glu Lys Gly Asn Ala Gly Phe Val Met Val Ile Val 
                485                 490                 495     


Leu Ile Val Leu Leu Met Leu Ala Ala Val Gly Val Gly Ile Phe Phe 
            500                 505                 510         


Val Val Lys Lys Arg Lys Ala Ala Pro Lys Phe Pro Met Glu Met Asn 
        515                 520                 525             


Gly Val Asn Asn Lys Gly Phe Ile Pro 
    530                 535         


<210>  448
<211>  585
<212>  PRT
<213>  Avian metapneumovirus

<400>  448

Met Glu Val Lys Val Glu Asn Val Gly Lys Ser Gln Glu Leu Lys Val 
1               5                   10                  15      


Lys Val Lys Asn Phe Ile Lys Arg Ser Asp Cys Lys Lys Lys Leu Phe 
            20                  25                  30          


Ala Leu Ile Leu Gly Leu Val Ser Phe Glu Leu Thr Met Asn Ile Met 
        35                  40                  45              


Leu Ser Val Met Tyr Val Glu Ser Asn Glu Ala Leu Ser Leu Cys Arg 
    50                  55                  60                  


Ile Gln Gly Thr Pro Ala Pro Arg Asp Asn Lys Thr Asn Thr Glu Asn 
65                  70                  75                  80  


Thr Lys Lys Glu Thr Thr Phe His Thr Thr Thr Thr Thr Arg Asp Pro 
                85                  90                  95      


Glu Val Arg Glu Thr Lys Thr Thr Lys Pro Lys Thr Asn Glu Gly Ala 
            100                 105                 110         


Thr Ser Pro Ser Arg Asn Leu Thr Thr Lys Gly Asp Ile His Gln Thr 
        115                 120                 125             


Thr Arg Ala Thr Thr Glu Ala Glu Leu Glu Lys Gln Ser Lys Gln Thr 
    130                 135                 140                 


Ile Glu Pro Asp Thr Ser Thr Lys Lys His Thr Pro Thr Arg Pro Ser 
145                 150                 155                 160 


Ser Glu Ser Pro Thr Thr Thr Gln Ala Thr Ala Gln Leu Thr Thr Pro 
                165                 170                 175     


Thr Ala Pro Lys Ala Ser Ile Ala Pro Lys Asn Arg Gln Ala Thr Thr 
            180                 185                 190         


Lys Lys Thr Glu Thr Gly Thr Thr Thr Thr Ser Arg Ala Lys Lys Thr 
        195                 200                 205             


Asn Asn Pro Thr Glu Thr Ala Thr Thr Thr Leu Lys Ala Thr Thr Glu 
    210                 215                 220                 


Thr Gly Lys Gly Lys Glu Gly Pro Thr Gln His Thr Ile Lys Glu Gln 
225                 230                 235                 240 


Pro Glu Thr Thr Ala Gly Glu Thr Thr Thr Pro Gln Ser Arg Arg Thr 
                245                 250                 255     


Thr Ser Arg Pro Ala Pro Thr Thr Lys Thr Glu Glu Glu Ala Glu Thr 
            260                 265                 270         


Thr Lys Thr Arg Thr Thr Lys Ser Thr Gln Thr Ser Thr Gly Pro Pro 
        275                 280                 285             


Gly Pro Thr Arg Ser Thr Pro Ser Lys Thr Ala Thr Glu Asn Asn Lys 
    290                 295                 300                 


Arg Thr Thr Thr Ile Lys Arg Pro Asn Thr Ala Asn Thr Asp Ser Arg 
305                 310                 315                 320 


Gln Gln Thr Arg Thr Thr Ala Glu Gln Asp Arg Gln Ile Gln Thr Lys 
                325                 330                 335     


Ala Lys Pro Thr Thr Asn Gly Ala His Ala Gln Thr Thr Thr Thr Pro 
            340                 345                 350         


Glu His Asn Thr Asp Thr Thr Asn Ser Thr Lys Glu Ser Ser Lys Glu 
        355                 360                 365             


Asp Lys Thr Thr Arg Asp Pro Ser Ser Lys Thr Pro Thr Asp Gln Glu 
    370                 375                 380                 


Asp Ala Ser Lys Gly Thr Thr Ala Ala Asn Pro Arg Lys Asn Thr Glu 
385                 390                 395                 400 


Ala Asn Thr Arg Thr Pro Pro Thr Thr Thr Pro Thr Arg His Thr Thr 
                405                 410                 415     


Glu Ser Ala Thr Ser Thr Thr Gly Asp Lys Thr Lys Ala Lys Thr Thr 
            420                 425                 430         


Arg Trp Lys Ser Thr Ala Asp Arg Gln Pro Ile Arg Asn Ser Thr Thr 
        435                 440                 445             


Ala Glu Thr Lys Thr Ala Gln Ser Lys Gln Pro Thr Pro Lys Gln Leu 
    450                 455                 460                 


Ser Asn Asn Thr Thr Pro Glu Asn Thr Thr Pro Pro Asn Asn Lys Ser 
465                 470                 475                 480 


Ser Ser Gln Thr Asp Ala Ala Pro Thr Glu Glu Ile Glu Ile Arg Ser 
                485                 490                 495     


Ser Leu Trp Arg Arg Arg Tyr Val Tyr Gly Pro Cys Arg Glu Asn Val 
            500                 505                 510         


Leu Glu His Pro Met Asn Pro Cys Phe Lys Asp Asn Thr Thr Trp Ile 
        515                 520                 525             


Tyr Ser Asp Asn Gly Arg Asn Leu Pro Ala Gly Tyr Tyr Asp Ser Lys 
    530                 535                 540                 


Thr Asp Lys Ile Ile Cys Tyr Gly Ile Tyr Arg Gly Asn Ser Tyr Cys 
545                 550                 555                 560 


Tyr Gly Arg Ile Glu Cys Thr Cys Lys Asn Gly Thr Gly Leu Leu Ser 
                565                 570                 575     


Tyr Cys Cys Asn Ser Tyr Asn Trp Ser 
            580                 585 


<210>  449
<211>  539
<212>  PRT
<213>  Human metapneumovirus

<400>  449

Met Ser Trp Lys Val Val Ile Ile Phe Ser Leu Leu Ile Thr Pro Gln 
1               5                   10                  15      


His Gly Leu Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr 
            20                  25                  30          


Glu Gly Tyr Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe 
        35                  40                  45              


Thr Leu Glu Val Gly Asp Val Glu Asn Leu Thr Cys Ser Asp Gly Pro 
    50                  55                  60                  


Ser Leu Ile Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu 
65                  70                  75                  80  


Leu Lys Thr Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu 
                85                  90                  95      


Asn Pro Arg Gln Ser Arg Phe Val Leu Gly Ala Ile Ala Leu Gly Val 
            100                 105                 110         


Ala Thr Ala Ala Ala Val Thr Ala Gly Val Ala Ile Ala Lys Thr Ile 
        115                 120                 125             


Arg Leu Glu Ser Glu Val Thr Ala Ile Lys Asn Ala Leu Lys Thr Thr 
    130                 135                 140                 


Asn Glu Ala Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Thr 
145                 150                 155                 160 


Ala Val Arg Glu Leu Lys Asp Phe Val Ser Lys Asn Leu Thr Arg Ala 
                165                 170                 175     


Ile Asn Lys Asn Lys Cys Asp Ile Asp Asp Leu Lys Met Ala Val Ser 
            180                 185                 190         


Phe Ser Gln Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser 
        195                 200                 205             


Asp Asn Ala Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp 
    210                 215                 220                 


Ala Glu Leu Ala Arg Ala Val Ser Asn Met Pro Thr Ser Ala Gly Gln 
225                 230                 235                 240 


Ile Lys Leu Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe 
                245                 250                 255     


Gly Ile Leu Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln 
            260                 265                 270         


Leu Pro Ile Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Val Lys Ala 
        275                 280                 285             


Ala Pro Ser Cys Ser Gly Lys Lys Gly Asn Tyr Ala Cys Leu Leu Arg 
    290                 295                 300                 


Glu Asp Gln Gly Trp Tyr Cys Gln Asn Ala Gly Ser Thr Val Tyr Tyr 
305                 310                 315                 320 


Pro Asn Glu Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp 
                325                 330                 335     


Thr Ala Ala Gly Ile Asn Val Ala Glu Gln Ser Lys Glu Cys Asn Ile 
            340                 345                 350         


Asn Ile Ser Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His 
        355                 360                 365             


Pro Ile Ser Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys 
    370                 375                 380                 


Tyr Lys Gly Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile 
385                 390                 395                 400 


Lys Gln Leu Asn Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp 
                405                 410                 415     


Thr Val Thr Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly 
            420                 425                 430         


Glu Gln His Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro 
        435                 440                 445             


Ile Lys Phe Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe 
    450                 455                 460                 


Glu Asn Ile Glu Asn Ser Gln Ala Leu Val Asp Gln Ser Asn Arg Ile 
465                 470                 475                 480 


Leu Ser Ser Ala Glu Lys Gly Asn Thr Gly Phe Ile Ile Val Ile Ile 
                485                 490                 495     


Leu Ile Ala Val Leu Gly Ser Ser Met Ile Leu Val Ser Ile Phe Ile 
            500                 505                 510         


Ile Ile Lys Lys Thr Lys Lys Pro Thr Gly Ala Pro Pro Glu Leu Ser 
        515                 520                 525             


Gly Val Thr Asn Asn Gly Phe Ile Pro His Ser 
    530                 535                 


<210>  450
<211>  219
<212>  PRT
<213>  Human metapneumovirus

<400>  450

Met Glu Val Lys Val Glu Asn Ile Arg Ala Ile Asp Met Leu Lys Ala 
1               5                   10                  15      


Arg Val Lys Asn Arg Val Ala Arg Ser Lys Cys Phe Lys Asn Ala Ser 
            20                  25                  30          


Leu Ile Leu Ile Gly Ile Thr Thr Leu Ser Ile Ala Leu Asn Ile Tyr 
        35                  40                  45              


Leu Ile Ile Asn Tyr Thr Ile Gln Lys Thr Ser Ser Glu Ser Glu His 
    50                  55                  60                  


His Thr Ser Ser Pro Pro Thr Glu Ser Asn Lys Glu Ala Ser Thr Ile 
65                  70                  75                  80  


Ser Thr Asp Asn Pro Asp Ile Asn Pro Asn Ser Gln His Pro Thr Gln 
                85                  90                  95      


Gln Ser Thr Glu Asn Pro Thr Leu Asn Pro Ala Ala Ser Val Ser Pro 
            100                 105                 110         


Ser Glu Thr Glu Pro Ala Ser Thr Pro Asp Thr Thr Asn Arg Leu Ser 
        115                 120                 125             


Ser Val Asp Arg Ser Thr Ala Gln Pro Ser Glu Ser Arg Thr Lys Thr 
    130                 135                 140                 


Lys Pro Thr Val His Thr Arg Asn Asn Pro Ser Thr Ala Ser Ser Thr 
145                 150                 155                 160 


Gln Ser Pro Pro Arg Ala Thr Thr Lys Ala Ile Arg Arg Ala Thr Thr 
                165                 170                 175     


Phe Arg Met Ser Ser Thr Gly Lys Arg Pro Thr Thr Thr Ser Val Gln 
            180                 185                 190         


Ser Asp Ser Ser Thr Thr Thr Gln Asn His Glu Glu Thr Gly Ser Ala 
        195                 200                 205             


Asn Pro Gln Ala Ser Val Ser Thr Met Gln Asn 
    210                 215                 


<210>  451
<211>  572
<212>  PRT
<213>  Bovine orthopneumovirus

<400>  451

Met Ala Thr Thr Thr Met Arg Met Ile Ile Ser Ile Ile Leu Ile Ser 
1               5                   10                  15      


Thr Tyr Val Pro His Ile Thr Leu Cys Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          


Tyr Gln Ser Thr Cys Ser Ala Val Ser Arg Gly Tyr Leu Ser Ala Leu 
        35                  40                  45              


Arg Thr Gly Trp Tyr Thr Ser Val Val Thr Ile Glu Leu Ser Lys Ile 
    50                  55                  60                  


Gln Lys Asn Val Cys Asn Gly Thr Asp Ser Lys Val Lys Leu Ile Lys 
65                  70                  75                  80  


Gln Glu Leu Glu Arg Tyr Asn Asn Ala Val Ala Glu Leu Gln Ser Leu 
                85                  90                  95      


Met Gln Asn Glu Pro Thr Ser Ser Ser Arg Ala Lys Arg Gly Ile Pro 
            100                 105                 110         


Glu Ser Ile His Tyr Thr Arg Asn Ser Thr Lys Lys Phe Tyr Gly Leu 
        115                 120                 125             


Met Gly Lys Lys Arg Lys Arg Arg Phe Leu Gly Phe Leu Leu Gly Ile 
    130                 135                 140                 


Gly Ser Ala Ile Ala Ser Gly Val Ala Val Ser Lys Val Leu His Leu 
145                 150                 155                 160 


Glu Gly Glu Val Asn Lys Ile Lys Asn Ala Leu Leu Ser Thr Asn Lys 
                165                 170                 175     


Ala Val Val Ser Leu Ser Asn Gly Val Ser Val Leu Thr Ser Lys Val 
            180                 185                 190         


Leu Asp Leu Lys Asn Tyr Ile Asp Lys Glu Leu Leu Pro Lys Val Asn 
        195                 200                 205             


Asn His Asp Cys Arg Ile Ser Asn Ile Ala Thr Val Ile Glu Phe Gln 
    210                 215                 220                 


Gln Lys Asn Asn Arg Leu Leu Glu Ile Ala Arg Glu Phe Ser Val Asn 
225                 230                 235                 240 


Ala Gly Ile Thr Thr Pro Leu Ser Thr Tyr Met Leu Thr Asn Ser Glu 
                245                 250                 255     


Leu Leu Ser Ile Ile Asn Asp Met Pro Ile Thr Asn Asp Gln Lys Lys 
            260                 265                 270         


Leu Met Ser Val Cys Gln Ile Val Arg Gln Gln Ser Tyr Ser Ile Met 
        275                 280                 285             


Ser Val Leu Arg Glu Val Ile Ala Tyr Val Val Gln Leu Pro Leu Tyr 
    290                 295                 300                 


Gly Val Ile Asp Thr Pro Cys Trp Lys Leu His Thr Ser Pro Leu Cys 
305                 310                 315                 320 


Thr Thr Asp Asn Lys Glu Gly Ser Asn Ile Cys Leu Thr Arg Thr Asp 
                325                 330                 335     


Arg Gly Trp Tyr Cys Asp Asn Ala Gly Ser Val Ser Phe Phe Pro Gln 
            340                 345                 350         


Ala Glu Thr Cys Lys Val Gln Ser Asn Arg Val Phe Cys Asp Thr Met 
        355                 360                 365             


Asn Ser Leu Thr Leu Pro Thr Asp Val Asn Leu Cys Asn Thr Asp Ile 
    370                 375                 380                 


Phe Asn Ser Lys Tyr Asp Cys Lys Ile Met Thr Ser Lys Thr Asp Ile 
385                 390                 395                 400 


Ser Ser Ser Val Ile Thr Ser Ile Gly Ala Ile Val Ser Cys Tyr Gly 
                405                 410                 415     


Lys Thr Lys Cys Thr Ala Ser Asn Lys Asn Arg Gly Ile Ile Lys Thr 
            420                 425                 430         


Phe Ser Asn Gly Cys Asp Tyr Val Ser Asn Lys Gly Val Asp Thr Val 
        435                 440                 445             


Ser Val Gly Asn Thr Leu Tyr Tyr Val Asn Lys Leu Glu Gly Lys Ala 
    450                 455                 460                 


Leu Tyr Ile Lys Gly Glu Pro Ile Ile Asn Tyr Tyr Asn Pro Leu Val 
465                 470                 475                 480 


Phe Pro Ser Asp Glu Phe Asp Ala Ser Ile Ala Gln Val Asn Ala Lys 
                485                 490                 495     


Ile Asn Gln Ser Leu Ala Phe Ile Arg Arg Ser Asp Glu Leu Leu His 
            500                 505                 510         


Ser Val Asp Val Gly Lys Ser Thr Thr Asn Val Val Ile Thr Thr Ile 
        515                 520                 525             


Ile Ile Val Ile Val Val Val Ile Leu Met Leu Ile Thr Val Gly Leu 
    530                 535                 540                 


Leu Phe Tyr Cys Lys Thr Arg Ser Thr Pro Ile Met Leu Gly Lys Asp 
545                 550                 555                 560 


Gln Leu Ser Ser Ile Asn Asn Leu Ser Phe Ser Lys 
                565                 570         


<210>  452
<211>  263
<212>  PRT
<213>  Bovine orthopneumovirus

<400>  452

Met Ser Asn His Thr His His Pro Lys Phe Lys Thr Leu Lys Arg Ala 
1               5                   10                  15      


Trp Lys Ala Ser Lys Tyr Phe Ile Val Gly Leu Ser Cys Leu Tyr Lys 
            20                  25                  30          


Phe Asn Leu Lys Ser Leu Val Gln Thr Ala Leu Thr Ser Leu Ala Met 
        35                  40                  45              


Ile Thr Leu Thr Ser Leu Val Ile Thr Ala Ile Ile Tyr Ile Ser Val 
    50                  55                  60                  


Gly Asn Ala Lys Ala Lys Pro Thr Ser Lys Pro Thr Thr Gln Gln Thr 
65                  70                  75                  80  


Gln Gln Pro Gln Asn His Thr Pro Leu Leu Pro Thr Glu His Asn His 
                85                  90                  95      


Lys Ser Thr His Thr Ser Thr Gln Ser Thr Thr Leu Ser Gln Pro Pro 
            100                 105                 110         


Asn Ile Asp Thr Thr Ser Gly Thr Thr Tyr Gly His Pro Ile Asn Arg 
        115                 120                 125             


Thr Gln Asn Arg Lys Ile Lys Ser Gln Ser Thr Pro Leu Ala Thr Arg 
    130                 135                 140                 


Lys Leu Pro Ile Asn Pro Leu Glu Ser Asn Pro Pro Glu Asn His Gln 
145                 150                 155                 160 


Asp His Asn Asn Ser Gln Thr Leu Pro His Val Pro Cys Ser Thr Cys 
                165                 170                 175     


Glu Gly Asn Pro Ala Cys Ser Pro Leu Cys Gln Ile Gly Leu Glu Arg 
            180                 185                 190         


Ala Pro Ser Arg Ala Pro Thr Ile Thr Leu Lys Lys Ala Pro Lys Pro 
        195                 200                 205             


Lys Thr Thr Lys Lys Pro Thr Lys Thr Thr Ile Tyr His Arg Thr Ser 
    210                 215                 220                 


Pro Glu Ala Lys Leu Gln Thr Lys Lys Asn Thr Ala Thr Pro Gln Gln 
225                 230                 235                 240 


Gly Ile Leu Ser Ser Pro Glu His Gln Thr Asn Gln Ser Thr Thr Gln 
                245                 250                 255     


Ile Ser Gln His Thr Ser Ile 
            260             


<210>  453
<211>  574
<212>  PRT
<213>  Human orthopneumovirus

<400>  453

Met Glu Leu Leu Ile Leu Lys Ala Asn Ala Ile Thr Thr Ile Leu Thr 
1               5                   10                  15      


Ala Val Thr Phe Cys Phe Ala Ser Gly Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          


Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Ser Ala Leu 
        35                  40                  45              


Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  


Lys Glu Asn Lys Cys Asn Gly Thr Asp Ala Lys Val Lys Leu Ile Lys 
65                  70                  75                  80  


Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 
                85                  90                  95      


Met Gln Ser Thr Pro Pro Thr Asn Asn Arg Ala Arg Arg Glu Leu Pro 
            100                 105                 110         


Arg Phe Met Asn Tyr Thr Leu Asn Asn Ala Lys Lys Thr Asn Val Thr 
        115                 120                 125             


Leu Ser Lys Lys Arg Lys Arg Arg Phe Leu Gly Phe Leu Leu Gly Val 
    130                 135                 140                 


Gly Ser Ala Ile Ala Ser Gly Val Ala Val Ser Lys Val Leu His Leu 
145                 150                 155                 160 


Glu Gly Glu Val Asn Lys Ile Lys Ser Ala Leu Leu Ser Thr Asn Lys 
                165                 170                 175     


Ala Val Val Ser Leu Ser Asn Gly Val Ser Val Leu Thr Ser Lys Val 
            180                 185                 190         


Leu Asp Leu Lys Asn Tyr Ile Asp Lys Gln Leu Leu Pro Ile Val Asn 
        195                 200                 205             


Lys Gln Ser Cys Ser Ile Ser Asn Ile Glu Thr Val Ile Glu Phe Gln 
    210                 215                 220                 


Gln Lys Asn Asn Arg Leu Leu Glu Ile Thr Arg Glu Phe Ser Val Asn 
225                 230                 235                 240 


Ala Gly Val Thr Thr Pro Val Ser Thr Tyr Met Leu Thr Asn Ser Glu 
                245                 250                 255     


Leu Leu Ser Leu Ile Asn Asp Met Pro Ile Thr Asn Asp Gln Lys Lys 
            260                 265                 270         


Leu Met Ser Asn Asn Val Gln Ile Val Arg Gln Gln Ser Tyr Ser Ile 
        275                 280                 285             


Met Ser Ile Ile Lys Glu Glu Val Leu Ala Tyr Val Val Gln Leu Pro 
    290                 295                 300                 


Leu Tyr Gly Val Ile Asp Thr Pro Cys Trp Lys Leu His Thr Ser Pro 
305                 310                 315                 320 


Leu Cys Thr Thr Asn Thr Lys Glu Gly Ser Asn Ile Cys Leu Thr Arg 
                325                 330                 335     


Thr Asp Arg Gly Trp Tyr Cys Asp Asn Ala Gly Ser Val Ser Phe Phe 
            340                 345                 350         


Pro Gln Ala Glu Thr Cys Lys Val Gln Ser Asn Arg Val Phe Cys Asp 
        355                 360                 365             


Thr Met Asn Ser Leu Thr Leu Pro Ser Glu Ile Asn Leu Cys Asn Val 
    370                 375                 380                 


Asp Ile Phe Asn Pro Lys Tyr Asp Cys Lys Ile Met Thr Ser Lys Thr 
385                 390                 395                 400 


Asp Val Ser Ser Ser Val Ile Thr Ser Leu Gly Ala Ile Val Ser Cys 
                405                 410                 415     


Tyr Gly Lys Thr Lys Cys Thr Ala Ser Asn Lys Asn Arg Gly Ile Ile 
            420                 425                 430         


Lys Thr Phe Ser Asn Gly Cys Asp Tyr Val Ser Asn Lys Gly Met Asp 
        435                 440                 445             


Thr Val Ser Val Gly Asn Thr Leu Tyr Tyr Val Asn Lys Gln Glu Gly 
    450                 455                 460                 


Lys Ser Leu Tyr Val Lys Gly Glu Pro Ile Ile Asn Phe Tyr Asp Pro 
465                 470                 475                 480 


Leu Val Phe Pro Ser Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Asn 
                485                 490                 495     


Glu Lys Ile Asn Gln Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu 
            500                 505                 510         


Leu His Asn Val Asn Ala Gly Lys Ser Thr Thr Asn Ile Met Ile Thr 
        515                 520                 525             


Thr Ile Ile Ile Val Ile Ile Val Ile Leu Leu Ser Leu Ile Ala Val 
    530                 535                 540                 


Gly Leu Leu Leu Tyr Cys Lys Ala Arg Ser Thr Pro Val Thr Leu Ser 
545                 550                 555                 560 


Lys Asp Gln Leu Ser Gly Ile Asn Asn Ile Ala Phe Ser Asn 
                565                 570                 


<210>  454
<211>  298
<212>  PRT
<213>  Human orthopneumovirus

<400>  454

Met Ser Lys Asn Lys Asp Gln Arg Thr Ala Lys Thr Leu Glu Arg Thr 
1               5                   10                  15      


Trp Asp Thr Leu Asn His Leu Leu Phe Ile Ser Ser Cys Leu Tyr Lys 
            20                  25                  30          


Leu Asn Leu Lys Ser Val Ala Gln Ile Thr Leu Ser Ile Leu Ala Met 
        35                  40                  45              


Ile Ile Ser Thr Ser Leu Ile Ile Ala Ala Ile Ile Phe Ile Ala Ser 
    50                  55                  60                  


Ala Asn His Lys Val Thr Pro Thr Thr Ala Ile Ile Gln Asp Ala Thr 
65                  70                  75                  80  


Ser Gln Ile Lys Asn Thr Thr Pro Thr Tyr Leu Thr Gln Asn Pro Gln 
                85                  90                  95      


Leu Gly Ile Ser Pro Ser Asn Pro Ser Glu Ile Thr Ser Gln Ile Thr 
            100                 105                 110         


Thr Ile Leu Ala Ser Thr Thr Pro Gly Val Lys Ser Thr Leu Gln Ser 
        115                 120                 125             


Thr Thr Val Lys Thr Lys Asn Thr Thr Thr Thr Gln Thr Gln Pro Ser 
    130                 135                 140                 


Lys Pro Thr Thr Lys Gln Arg Gln Asn Lys Pro Pro Ser Lys Pro Asn 
145                 150                 155                 160 


Asn Asp Phe His Phe Glu Val Phe Asn Phe Val Pro Cys Ser Ile Cys 
                165                 170                 175     


Ser Asn Asn Pro Thr Cys Trp Ala Ile Cys Lys Arg Ile Pro Asn Lys 
            180                 185                 190         


Lys Pro Gly Lys Lys Thr Thr Thr Lys Pro Thr Lys Lys Pro Thr Leu 
        195                 200                 205             


Lys Thr Thr Lys Lys Asp Pro Lys Pro Gln Thr Thr Lys Ser Lys Glu 
    210                 215                 220                 


Val Pro Thr Thr Lys Pro Thr Glu Glu Pro Thr Ile Asn Thr Thr Lys 
225                 230                 235                 240 


Thr Asn Ile Ile Thr Thr Leu Leu Thr Ser Asn Thr Thr Gly Asn Pro 
                245                 250                 255     


Glu Leu Thr Ser Gln Met Glu Thr Phe His Ser Thr Ser Ser Glu Gly 
            260                 265                 270         


Asn Pro Ser Pro Ser Gln Val Ser Thr Thr Ser Glu Tyr Pro Ser Gln 
        275                 280                 285             


Pro Ser Ser Pro Pro Asn Thr Pro Arg Gln 
    290                 295             


<210>  455
<211>  537
<212>  PRT
<213>  Murine orthopneumovirus

<400>  455

Met Ile Pro Gly Arg Ile Phe Leu Val Leu Leu Val Ile Phe Asn Thr 
1               5                   10                  15      


Lys Pro Ile His Pro Asn Thr Leu Thr Glu Lys Tyr Tyr Glu Ser Thr 
            20                  25                  30          


Cys Ser Val Glu Thr Ala Gly Tyr Lys Ser Ala Leu Arg Thr Gly Trp 
        35                  40                  45              


His Met Thr Val Met Ser Ile Lys Leu Ser Gln Ile Asn Ile Glu Ser 
    50                  55                  60                  


Cys Lys Ser Ser Asn Ser Leu Leu Ala His Glu Leu Ala Ile Tyr Ser 
65                  70                  75                  80  


Ser Ala Val Asp Glu Leu Arg Thr Leu Ser Ser Asn Ala Leu Lys Ser 
                85                  90                  95      


Lys Arg Lys Lys Arg Phe Leu Gly Leu Ile Leu Gly Leu Gly Ala Ala 
            100                 105                 110         


Val Thr Ala Gly Val Ala Leu Ala Lys Thr Val Gln Leu Glu Ser Glu 
        115                 120                 125             


Ile Ala Leu Ile Arg Asp Ala Val Arg Asn Thr Asn Glu Ala Val Val 
    130                 135                 140                 


Ser Leu Thr Asn Gly Met Ser Val Leu Ala Lys Val Val Asp Asp Leu 
145                 150                 155                 160 


Lys Asn Phe Ile Ser Lys Glu Leu Leu Pro Lys Ile Asn Arg Val Ser 
                165                 170                 175     


Cys Asp Val His Asp Ile Thr Ala Val Ile Arg Phe Gln Gln Leu Asn 
            180                 185                 190         


Lys Arg Leu Leu Glu Val Ser Arg Glu Phe Ser Ser Asn Ala Gly Leu 
        195                 200                 205             


Thr His Thr Val Ser Ser Phe Met Leu Thr Asp Arg Glu Leu Thr Ser 
    210                 215                 220                 


Ile Val Gly Gly Met Ala Val Ser Ala Gly Gln Lys Glu Ile Met Leu 
225                 230                 235                 240 


Ser Ser Lys Ala Ile Met Arg Arg Asn Gly Leu Ala Ile Leu Ser Ser 
                245                 250                 255     


Val Asn Ala Asp Thr Leu Val Tyr Val Ile Gln Leu Pro Leu Phe Gly 
            260                 265                 270         


Val Met Asp Thr Asp Cys Trp Val Ile Arg Ser Ser Ile Asp Cys His 
        275                 280                 285             


Asn Ile Ala Asp Lys Tyr Ala Cys Leu Ala Arg Ala Asp Asn Gly Trp 
    290                 295                 300                 


Tyr Cys His Asn Ala Gly Ser Leu Ser Tyr Phe Pro Ser Pro Thr Asp 
305                 310                 315                 320 


Cys Glu Ile His Asn Gly Tyr Ala Phe Cys Asp Thr Leu Lys Ser Leu 
                325                 330                 335     


Thr Val Pro Val Thr Ser Arg Glu Cys Asn Ser Asn Met Tyr Thr Thr 
            340                 345                 350         


Asn Tyr Asp Cys Lys Ile Ser Thr Ser Lys Thr Tyr Val Ser Thr Ala 
        355                 360                 365             


Val Leu Thr Thr Met Gly Cys Leu Val Ser Cys Tyr Gly His Asn Ser 
    370                 375                 380                 


Cys Thr Val Ile Asn Asn Asp Lys Gly Ile Ile Arg Thr Leu Pro Asp 
385                 390                 395                 400 


Gly Cys His Tyr Ile Ser Asn Lys Gly Val Asp Arg Val Gln Val Gly 
                405                 410                 415     


Asn Thr Val Tyr Tyr Leu Ser Lys Glu Val Gly Lys Ser Ile Val Val 
            420                 425                 430         


Arg Gly Glu Pro Leu Val Leu Lys Tyr Asp Pro Leu Ser Phe Pro Asp 
        435                 440                 445             


Asp Lys Phe Asp Val Ala Ile Arg Asp Val Glu His Ser Ile Asn Gln 
    450                 455                 460                 


Thr Arg Thr Phe Phe Lys Ala Ser Asp Gln Leu Leu Asp Leu Ser Glu 
465                 470                 475                 480 


Asn Arg Glu Asn Lys Asn Leu Asn Lys Ser Tyr Ile Leu Thr Thr Leu 
                485                 490                 495     


Leu Phe Val Val Met Leu Ile Ile Ile Met Ala Val Ile Gly Phe Ile 
            500                 505                 510         


Leu Tyr Lys Val Leu Lys Met Ile Arg Asp Asn Lys Leu Lys Ser Lys 
        515                 520                 525             


Ser Thr Pro Gly Leu Thr Val Leu Ser 
    530                 535         


<210>  456
<211>  396
<212>  PRT
<213>  Murine orthopneumovirus

<400>  456

Met Gly Arg Asn Leu Glu Val Ser Gly Ser Ile Thr Asn Leu Asn Phe 
1               5                   10                  15      


Glu Arg Thr Gln His Pro Asp Thr Phe Arg Thr Val Val Lys Val Asn 
            20                  25                  30          


Gln Met Cys Lys Leu Ile Ala Gly Val Leu Thr Ser Ala Ala Val Ala 
        35                  40                  45              


Val Cys Val Gly Val Ile Met Tyr Ser Val Phe Thr Ser Asn His Lys 
    50                  55                  60                  


Ala Asn Ser Thr Gln Asn Ala Thr Thr Arg Asn Ser Thr Ser Thr Pro 
65                  70                  75                  80  


Pro Gln Pro Thr Ala Gly Leu Pro Thr Thr Glu Gln Gly Thr Ile Pro 
                85                  90                  95      


Arg Phe Thr Lys Pro Pro Thr Lys Thr Ala Thr His His Glu Ile Thr 
            100                 105                 110         


Glu Pro Val Lys Met Ala Thr Pro Ser Glu Asp Pro Tyr Gln Cys Ser 
        115                 120                 125             


Ser Asn Gly Tyr Leu Asp Arg Pro Asp Leu Pro Glu Asn Phe Lys Leu 
    130                 135                 140                 


Val Leu Asp Val Ile Cys Lys Pro Pro Gly Pro Glu His His Asn Thr 
145                 150                 155                 160 


Ser Cys Tyr Glu Lys Arg Glu Ile Asn Pro Gly Ser Val Cys Pro Asp 
                165                 170                 175     


Leu Val Thr Met Lys Ala Asn Met Gly Leu Asn Asn Gly Gly Gly Glu 
            180                 185                 190         


Asp Ala Ala Pro Tyr Ile Glu Val Thr Thr Leu Ser Thr Tyr Ser Asn 
        195                 200                 205             


Lys Arg Ala Met Cys Val His Asn Gly Cys Asp Gln Gly Phe Cys Phe 
    210                 215                 220                 


Phe Leu Ser Gly Leu Ser Thr Asp Gln Glu Arg Ala Val Leu Glu Leu 
225                 230                 235                 240 


Gly Gly Gln Gln Ala Ile Met Glu Leu His Tyr Asp Ser Tyr Trp Lys 
                245                 250                 255     


His Tyr Trp Ser Asn Ser Asn Cys Val Val Pro Arg Thr Asn Cys Asn 
            260                 265                 270         


Leu Thr Asp Gln Thr Glu Ile Leu Phe Pro Arg Phe Asn Asn Lys Asn 
        275                 280                 285             


Gln Ser Gln Cys Thr Thr Cys Ala Asp Ser Ala Gly Leu Asp Asn Lys 
    290                 295                 300                 


Phe Tyr Leu Thr Cys Asp Gly Leu Leu Arg Thr Leu Pro Leu Val Gly 
305                 310                 315                 320 


Leu Pro Ser Leu Ser Pro Gln Ala Tyr Lys Ala Val Pro Thr Gln Thr 
                325                 330                 335     


Thr Gly Thr Thr Thr Ala Pro Thr Ser Glu Thr Arg His Pro Thr Pro 
            340                 345                 350         


Ala Pro Arg Arg Ser Lys Pro Leu Ser Arg Lys Lys Arg Ala Leu Cys 
        355                 360                 365             


Gly Val Asp Ser Ser Arg Glu Pro Lys Pro Thr Met Pro Tyr Trp Cys 
    370                 375                 380                 


Pro Met Leu Gln Leu Phe Pro Arg Arg Ser Asn Ser 
385                 390                 395     


<210>  457
<211>  476
<212>  PRT
<213>  Arboretum almendravirus

<400>  457

Met Ile Ala His Lys Leu Ile Leu Pro Leu Val Ile Leu Thr Ser Phe 
1               5                   10                  15      


Gln Arg Ile Lys Arg Glu Asp Ile Thr Cys Pro Val Tyr Asn His Lys 
            20                  25                  30          


Asn Val Asn Val Ser Ser Gln Ser Leu Leu Gln Phe Asp Met Arg Gln 
        35                  40                  45              


Val Ser Phe Asn Ser Gly Glu Glu Ile Ile Asn His Asn Pro Leu Val 
    50                  55                  60                  


Thr Gly Tyr Leu Cys Arg Lys Leu Ser Tyr Glu Thr Ser Cys Tyr Ala 
65                  70                  75                  80  


Asn Leu Phe Thr Ser Asn Thr Val Glu Tyr Lys Leu Lys Ile Leu Pro 
                85                  90                  95      


Ile Thr Lys Lys Glu Cys Ala Thr Gly Ser Asn Ser Gln Val Lys Ser 
            100                 105                 110         


Phe Pro Thr Pro Ile Cys Asn Trp Ser Met Phe Gly Ser Asn Thr Val 
        115                 120                 125             


Lys Glu Thr Lys Gln Tyr Ile Glu Tyr Glu Gln Arg Ser Tyr Lys Leu 
    130                 135                 140                 


Asp Met Val Ser Gly Lys Leu Lys His Val Glu Glu Ile Phe Asp Lys 
145                 150                 155                 160 


Cys Tyr Glu Glu Tyr Cys Val Leu Lys Asp Asn Ser Gly Tyr Trp Ile 
                165                 170                 175     


Arg Asp Asp Gln Asp Glu Lys Lys Tyr Cys Pro Lys Leu Glu Asp Gln 
            180                 185                 190         


Lys Ile Pro Ala Lys Leu Lys Val Ile Asp Gln Phe Glu Tyr Leu Glu 
        195                 200                 205             


Val Ala Gln His Ile Tyr Asp Met Gln Glu Leu Cys Ala Leu Glu Val 
    210                 215                 220                 


Cys Gly Asn Met Leu Ile His Ile Pro Asp Ile Gly Asn Phe Ile Gly 
225                 230                 235                 240 


Asp Asp Arg Phe Met Lys Lys Leu Lys Lys Cys Lys Ser Leu Pro Ser 
                245                 250                 255     


Leu Arg Asn Ala Ile Glu Asn Asn Ser Glu Asp Ile Thr Gly Asn Glu 
            260                 265                 270         


Lys Cys Leu Asp Phe Arg Leu Lys Met Leu Gly Asn Pro Asp Lys Ser 
        275                 280                 285             


Ile Lys Tyr His Asp Ile Arg Asn Leu His Pro Arg Ser Pro Gly Ile 
    290                 295                 300                 


Asn Arg Val Tyr Arg Leu Gly Glu Asn Asn Thr Leu Glu Ser Ala Ile 
305                 310                 315                 320 


Ala Tyr Tyr Gly Ser Thr Gly Leu Asp Lys Ile Ser Lys Lys Leu Asn 
                325                 330                 335     


Tyr Trp Val Asn Cys Thr Glu Asp Lys Val Cys Ser Tyr Asn Gly Tyr 
            340                 345                 350         


Met Gly Lys Asp Lys Leu His Leu Arg Ser Lys Leu Asp Ser Glu Thr 
        355                 360                 365             


Tyr Gln Asp Ile Phe Glu Val Asp Asp Glu Leu Ile Val Tyr Gln Pro 
    370                 375                 380                 


Thr Arg Asn Ile Ser Glu Ser Phe Tyr Lys Asp Val Ile His Tyr Glu 
385                 390                 395                 400 


Leu Leu Asp Lys Met Thr Gln Asn Phe Ser Ile Phe Asn Ser Asn Tyr 
                405                 410                 415     


Tyr Ser Lys Ile Ile Tyr Ala Leu Leu Ile Ile Leu Ala Val Phe Phe 
            420                 425                 430         


Ile Tyr Lys Ile Met Lys Leu Leu Thr Leu Arg Cys Phe Lys Asn Gln 
        435                 440                 445             


Ser Lys Phe Gly Lys Phe Tyr Gln Ile Ser Thr Asn Lys Ser Gln Glu 
    450                 455                 460                 


Leu Asp Met Met Arg Lys Asp Ile Ser Gln Trp Lys 
465                 470                 475     


<210>  458
<211>  451
<212>  PRT
<213>  Menghai almendravirus

<400>  458

Met His Val Ile Ile Pro Val Leu Met Ile Thr Ala Phe Lys Ala Ile 
1               5                   10                  15      


Asn Phe Asn Glu Leu Leu Cys Pro Asp Gly Lys Glu Met Lys Val Asp 
            20                  25                  30          


Glu Ser Asn Phe Gly Leu Leu Asn Lys Tyr Met Ala Pro Glu Tyr Asp 
        35                  40                  45              


Ile Asn Glu Gly Ser Leu Asn Pro Tyr Glu Ile Lys Gly Arg Asp Cys 
    50                  55                  60                  


Tyr Ser Ala Val Phe Lys Thr Gly Cys Lys Phe His Tyr Phe Gly Ser 
65                  70                  75                  80  


Asn Asp Ile Ile Gln Val Ile Glu Lys Lys Thr Thr Asp Arg Lys Asn 
                85                  90                  95      


Cys Asn Gln Val Ser Thr Asp Val Leu Thr Phe Pro Glu Ala Asn Cys 
            100                 105                 110         


Val Ser Gly Leu Phe Asp Asn Ser Tyr His Tyr Lys Glu Ile Glu Tyr 
        115                 120                 125             


Ile Val Thr Lys Pro Arg Ser Tyr Met Tyr Asp Pro Ser Thr Gly Glu 
    130                 135                 140                 


Ile Val Asp Asp Lys Asn Ile Phe Asp Lys Lys Val Asp Asn Val Tyr 
145                 150                 155                 160 


His Tyr Lys Asp Asn Lys Gly Tyr Trp Thr Met Asp Glu Thr Gln Pro 
                165                 170                 175     


Ala Thr Thr Cys Glu Thr Phe Lys Gln His Glu Ser Ser Glu Val Glu 
            180                 185                 190         


Val Lys Ile Trp Lys Ser Arg Met Asn Asn Lys Ser Leu Ile Asp Leu 
        195                 200                 205             


Gly Gly Lys Ile Tyr Asp Met Asp Glu Leu Cys Tyr His Asp His Cys 
    210                 215                 220                 


Gly Val Lys Ile Ala Val Thr Lys Asp His Val Tyr Phe Lys Leu Pro 
225                 230                 235                 240 


Thr Asn Leu Glu Ile Arg Lys Cys Ser Phe Asp Tyr Lys Lys Val Tyr 
                245                 250                 255     


Leu Gln Ser Glu Ile Ile Gln Glu Lys Ser Glu Leu Lys Asp Cys Leu 
            260                 265                 270         


Glu Ala Lys Ile Asp Met Ala Trp Met Lys Ser Ile Asn Tyr Glu Asp 
        275                 280                 285             


Leu Lys Lys Phe Asn Pro Ser Ser Ser Gly Ile His Pro Val Tyr Lys 
    290                 295                 300                 


Leu Asn Asn Asn Asn Thr Leu Met Lys Ala Leu Ala Lys Tyr Ser Glu 
305                 310                 315                 320 


Val Asn Thr Thr Glu Leu His Lys Tyr Leu Glu Trp Val Arg Cys Gly 
                325                 330                 335     


Asn Lys Thr Lys Cys Thr Tyr Asn Gly Val Ile Lys Ala Asp Leu Val 
            340                 345                 350         


Glu Ile Tyr Gly Gln Lys Leu Thr Glu Lys Asp Phe Ala Val His Val 
        355                 360                 365             


Asp Glu Leu Lys Val Gly Ile Lys Ala Tyr Pro Arg Asp Thr Ile Asn 
    370                 375                 380                 


His Ser Asp His Thr Glu Glu Lys Thr Tyr Leu Lys Ser Asp Asn Ser 
385                 390                 395                 400 


Phe Val Ser Leu Phe Phe Ile Ala Ala Pro Trp Ile Ser Glu Gly Ile 
                405                 410                 415     


Leu Ile Leu Ile Ile Val Cys Ile Leu Ile Lys Tyr Ile Lys Pro Lys 
            420                 425                 430         


Asn Arg Arg His Arg Asp Ile Phe Leu Arg Arg Asn Asn Gln Asp Phe 
        435                 440                 445             


Glu Ser Trp 
    450     


<210>  459
<211>  470
<212>  PRT
<213>  Puerto Almendras almendravirus

<400>  459

Met Ile Thr His Lys Tyr Ile Leu Pro Ile Ile Val Leu Ser Asn Phe 
1               5                   10                  15      


Met Pro Val Lys Arg Asp Asp Leu Thr Cys Pro Ile Tyr Asn His Gln 
            20                  25                  30          


Asn Val Glu Phe Val Asn Thr Thr Ile Thr Tyr Ile Arg Leu Asn Ser 
        35                  40                  45              


Val Leu Leu Gln Ser Lys Ser Leu Glu Leu Lys Gln Met Pro Tyr Val 
    50                  55                  60                  


Arg Gly His Ile Cys Gln Lys Ile Arg Tyr Ile Thr Thr Cys Lys Ala 
65                  70                  75                  80  


Asn Leu Phe Thr Ser Asn Glu Ile Phe Tyr Lys Lys Glu Tyr Leu Thr 
                85                  90                  95      


Val Thr Lys Asn Asp Cys Glu Met Lys Ala Val His Glu Thr Gly Glu 
            100                 105                 110         


Tyr Pro Ala Pro Ile Cys Thr Trp Ser Leu Phe Gly Ser Asn Leu His 
        115                 120                 125             


Asn Glu Glu Ile Ile Val Thr Glu Ile Gln Ser His Asp Tyr His Tyr 
    130                 135                 140                 


Asp Leu Phe Asn Gly Lys Ile Lys Asp Ser Glu Tyr Leu Phe Glu His 
145                 150                 155                 160 


Cys Thr Leu Met Tyr Cys Lys Leu Arg Glu His Lys Gly Tyr Trp Ile 
                165                 170                 175     


Lys Ser Glu Pro Thr Lys Asn Asp Ile Cys Pro Ile Val Gln Asp Asp 
            180                 185                 190         


Glu Ile Val Ala Glu Leu Lys Phe Tyr Asn Glu Asn His Phe Leu Lys 
        195                 200                 205             


Ile Asn His His Leu Tyr Ser Thr Glu Glu Val Cys Lys Ile Lys Tyr 
    210                 215                 220                 


Cys Asn Asn Ser Leu Leu Phe Phe Lys Asp Ile Gly Phe Phe Asn Ile 
225                 230                 235                 240 


Lys Ser Thr Leu Gln Lys Met Asp Lys Ile Phe Lys Lys Cys Thr Lys 
                245                 250                 255     


Ile Glu Asp Leu Arg Tyr Ile Ile His Asp Asn Val Glu Lys Ile Asp 
            260                 265                 270         


Asn Leu Asn Asp Cys Leu Asn Phe Lys Leu Asn Val Leu Thr Asn Lys 
        275                 280                 285             


Asp Arg Thr Ile Ala Tyr His Asp Ile Arg Lys Leu His Pro Lys Gly 
    290                 295                 300                 


Thr Gly Ile Asn Arg Ile Tyr Arg Leu Asn Gly Asn Asn Thr Leu Glu 
305                 310                 315                 320 


Ser Ala Ile Ala Tyr Tyr Gly Ser Val Glu Ser Asn Glu Thr Lys Ile 
                325                 330                 335     


Tyr Leu Asp Tyr Trp Asn Asp Cys Ser Lys Thr His Thr Cys Thr Tyr 
            340                 345                 350         


Asn Gly Tyr Met Gly Lys Lys Gly Leu Asn Ile Arg Ala Arg Leu Asn 
        355                 360                 365             


Ile Asp Leu Phe Gln Glu Val Tyr Glu Glu Asp Ser Ser Leu Leu Ile 
    370                 375                 380                 


Tyr Asn Gly Thr Thr Asp Leu Ser Thr Gly Thr Ile Gly Glu Leu Thr 
385                 390                 395                 400 


Lys Gly Asp Ala Asn Val Thr Phe Thr Thr Lys Glu Trp Ile Pro His 
                405                 410                 415     


Ile Ser Asn Tyr Ile Ile Ile Ile Val Phe Cys Leu Leu Ser Gly Ala 
            420                 425                 430         


Val Phe Ile Ile Met Ile Asn Ile Tyr Asn Arg Ile Met Val Met Lys 
        435                 440                 445             


Arg Asn Arg Lys Ala Phe Tyr Asn Arg Glu Asn Asp Asn Arg Val Ile 
    450                 455                 460                 


Tyr Val Asn Asp Trp Lys 
465                 470 


<210>  460
<211>  702
<212>  PRT
<213>  Santabarbara arurhavirus

<400>  460

Met Lys Leu Phe Val Leu Ala Ile Val Cys Leu Gly Leu Arg Ser Arg 
1               5                   10                  15      


Val Ile Asn Cys Gln Asp Lys Gln Arg Tyr Val Ile Thr Asn Lys Gly 
            20                  25                  30          


Trp Leu Tyr Asp Thr Val Asp Asn Trp Tyr Leu Glu Pro Tyr Arg Pro 
        35                  40                  45              


Phe Gly Pro Pro Lys Thr Ile Glu Arg Gln Ile Glu Glu Lys Leu Asn 
    50                  55                  60                  


Leu Thr Lys Gly Asn Ile Pro Asn Lys Gly Ser Tyr Pro Ser Glu Ser 
65                  70                  75                  80  


Lys Met Tyr Met Tyr Asn Trp Pro Phe Gly Pro Tyr Leu Trp His Glu 
                85                  90                  95      


Leu Thr Pro Asp Ser Asn Ile Gly Cys Pro Lys Phe Lys Ser Asn Gln 
            100                 105                 110         


Gly Glu Leu Asn Asn Ile Asn Thr Lys Ile Thr Val Lys Arg Pro Ser 
        115                 120                 125             


His Pro Asp Gly Leu Phe Val Lys Gly Tyr Ile Cys Glu Gly Leu Glu 
    130                 135                 140                 


Trp Val Leu Thr Cys Ser Glu Thr Trp Tyr Trp Ser Val Ser Phe Thr 
145                 150                 155                 160 


Lys Gln Ile Lys Ser Phe Thr Pro Thr Leu Asp Glu Cys Gln Tyr Ser 
                165                 170                 175     


Val Lys Ala Tyr Glu Ser Gly Glu Pro Ile Thr Pro Tyr Phe Pro Glu 
            180                 185                 190         


Pro Leu Cys Phe Trp Asn Ala Asp His Thr Glu Ser Ile Lys Phe Thr 
        195                 200                 205             


Ile Thr Thr Gln His Ser Thr Leu Phe Asp Pro Tyr Arg Gly Met Leu 
    210                 215                 220                 


Asp Asp His Thr Met Val Val Asn Thr Cys Pro Tyr Asn Ser Thr Tyr 
225                 230                 235                 240 


Cys Lys Leu Lys Asp Val Asn Lys Ile Trp Val Arg Asp Asp Asn Asp 
                245                 250                 255     


Lys Tyr Arg Thr His Glu Ile Cys Lys Ile Asp Thr Trp Glu Glu Phe 
            260                 265                 270         


Asp Ala Asn Val Tyr Phe Leu Asp Leu Pro Asp Asn Ala Asn Ser Leu 
        275                 280                 285             


Asp Ala Asn Trp Lys Asn His Leu Leu Ile Glu Gly Glu Gly Ile Gly 
    290                 295                 300                 


Lys Lys Asp Leu Ser Arg Ala Cys Arg Met Phe Phe Cys Gly Ile Pro 
305                 310                 315                 320 


Gly Ile Arg Phe Pro Asp Arg Glu Trp Trp Ser Ile Lys Ile Asp Gly 
                325                 330                 335     


His Asn Asn Glu Val Glu Tyr Gln Asn Leu Asp Met Ile Pro Glu Cys 
            340                 345                 350         


Thr Asn Asn Gln Thr Ile Gly Leu Ser His Pro His Phe Lys Asp Ser 
        355                 360                 365             


Glu Glu Lys Ile Glu Val Leu Asp Ile Ile Lys Thr Val Arg Cys Ala 
    370                 375                 380                 


Glu Thr Leu Ser Lys Ile Tyr Ala Ser Phe Gln Ile Ser Pro Phe Asp 
385                 390                 395                 400 


Leu Ser Ala Leu Ala Gln Glu His Pro Gly Ile Gly Leu Val Phe Ser 
                405                 410                 415     


Leu Arg Lys Gln Asp Asn Gly Arg Ser Pro Lys Ile Tyr Trp Ser Tyr 
            420                 425                 430         


Ala Asn Tyr Lys Leu Ile Glu Val Ser Leu Asp Gln Asn Ser Glu Phe 
        435                 440                 445             


Asp Thr Ser Val Leu Gly Leu Lys Gln Asn Arg Thr Asn Leu Phe Val 
    450                 455                 460                 


Asp Ser Arg Leu Asn Glu His Gln Asn Glu Thr Met Pro Ile Thr Thr 
465                 470                 475                 480 


Ser Pro Lys Arg Glu Gly Ser Leu Ile Gly Trp Tyr His Asn Gln Glu 
                485                 490                 495     


Val Trp Ser Asn Glu Trp Tyr Ala Gly Ser Val Ala Gly Leu His Glu 
            500                 505                 510         


Val Gly Leu Asn Gly Ile Val Arg Glu Ser Leu Gly Asp Ser Lys Gln 
        515                 520                 525             


Cys Val Lys Asn Gly Ala Thr Leu Asn Cys Ser Asn Lys Pro Ser Ser 
    530                 535                 540                 


Ile Thr Lys Tyr Lys Ile Ile Phe Pro Ser Ala Ala Tyr Lys Met Gly 
545                 550                 555                 560 


Leu Val Thr Ser Met Ile Thr Lys Gly Ile Pro Ile Ser Asn Ile Leu 
                565                 570                 575     


Arg Pro Thr Asp Met Thr Gln Lys Glu Phe Asp Leu Glu Asn Pro Asn 
            580                 585                 590         


Asp Ile Val Arg Glu Thr Asp Ser Ile Asn Arg Val Asp Ile Val Asn 
        595                 600                 605             


Ser Thr Lys His Trp Trp Asn Gly Ile Thr His Ser Phe Ser Phe Gly 
    610                 615                 620                 


Phe Lys Ser Leu Leu Ala Trp Val Thr Thr Val Ile His Ile Ser Ile 
625                 630                 635                 640 


Ile Val Val Cys Ile Leu Ile Ile Val Lys Leu Tyr Lys Thr Cys Lys 
                645                 650                 655     


Arg Asn Gln Ser Gln Ala Thr His Ala Thr Lys Arg Thr Gly Lys Met 
            660                 665                 670         


Leu Asp Thr Ile Ile Gly Glu Asp His Leu Tyr Asp Thr Val Lys Thr 
        675                 680                 685             


Pro Ser Arg Asn Glu Asp Ile Arg Leu Asn Leu Phe Asn His 
    690                 695                 700         


<210>  461
<211>  668
<212>  PRT
<213>  Xiburema arurhavirus

<400>  461

Met Met Met Gln Lys Val Ile Val Leu Ala Met Val Ser Leu Cys Ala 
1               5                   10                  15      


Ser Val His Arg Ser Val His Lys Ile Gly Asn Leu Val Leu Cys Pro 
            20                  25                  30          


Asn Ser Pro Met Gly Ile Cys Leu Pro Gly His His Pro Pro Ile Pro 
        35                  40                  45              


Thr Thr Lys Lys Pro Ser Val Arg Asn Ile Ala Arg Leu Pro Arg Glu 
    50                  55                  60                  


Ile Leu Asn Arg Pro Glu Met Lys Asp Ile Gly Val Val Ile Ile Asp 
65                  70                  75                  80  


Arg Arg Leu Asp Gly Ser Ser Ile His Gly Lys Val Glu Arg Ala Thr 
                85                  90                  95      


Ile Gln Arg Lys Gln Gln Asn Pro Gln Glu Val Arg Glu Glu Glu Tyr 
            100                 105                 110         


Asp Gln Val Glu Gly Lys Val Thr Tyr Met Asn Trp Pro Ser Lys Ser 
        115                 120                 125             


Gly Glu Trp Thr Glu Asn Phe Gly Pro Thr Gly Pro Val Cys Pro Arg 
    130                 135                 140                 


Phe Ser Ser Gln Phe Tyr Ile Thr His Asp Lys Leu Ile Arg Ala Val 
145                 150                 155                 160 


Leu Thr Arg Pro Glu His Pro Glu Gly Val Phe Val Asp Gly Tyr Leu 
                165                 170                 175     


Cys Glu Ala Gln Ile Trp Ser Ser Lys Cys Thr Lys Thr Trp Tyr Phe 
            180                 185                 190         


Ser Tyr Gln Glu Glu Arg Ser Ile Ser Gly Ala Val Ala Glu Val Glu 
        195                 200                 205             


Lys Cys Phe Gln Ala Leu Glu Leu Gln Lys Ala Gly Asn Pro Val Lys 
    210                 215                 220                 


Pro Glu His Pro Leu Ser Val Cys Tyr Trp Asn Ala Glu His Thr Glu 
225                 230                 235                 240 


Ser Val Val Tyr His Leu Ile Thr Pro His Thr Ser Thr Val Asn Pro 
                245                 250                 255     


Tyr Thr Asn Lys Ile Val Asp Pro Leu Phe Leu Lys Gly Gly Cys Ser 
            260                 265                 270         


Leu Asp Ser His Ile Cys Gln Thr Ser Lys Leu Ser Val Met Trp Leu 
        275                 280                 285             


Arg Thr Gly His Asp Ser Pro Ser Met Val Cys Asn Val Asp Asn Trp 
    290                 295                 300                 


Lys Lys Gln Gln Ile Val Leu His Glu Val Asp Met Glu Thr His Glu 
305                 310                 315                 320 


Lys Gly Lys Trp Ala Arg Arg Thr Ile Leu Glu Gly Asp His Leu Gly 
                325                 330                 335     


Thr Lys Val Leu Glu Ser Gly Cys Arg Thr Lys Phe Cys Asn Leu Asn 
            340                 345                 350         


Gly Ile Arg Phe Asp Asp Ser Glu Trp Trp Thr Met Asp Pro His Glu 
        355                 360                 365             


Asp Phe Gln His Asn Pro Leu Tyr Gly Arg Ile Arg Asp Met Ile Ser 
    370                 375                 380                 


Gln Leu Pro Ile Cys Ser Glu Glu Lys Ser Lys Asp Ile Gly Ile Ala 
385                 390                 395                 400 


His Pro Asn Phe Glu Thr Ser Phe Leu Lys Lys Glu Met Gly Asn Met 
                405                 410                 415     


Leu Arg Ala Leu Arg Cys Asn Asp Ala Val Gly Lys Ile Leu Glu Gly 
            420                 425                 430         


Glu Ser Ile Thr Pro Val Asp Leu Ser Ala Leu Ala Pro Thr Ser Pro 
        435                 440                 445             


Gly Pro Gly Ile Met Tyr Lys Leu Glu Glu Thr Glu Gly Gly Gln Ile 
    450                 455                 460                 


Val Leu Lys Trp Ala His Ala Asn Tyr Ser Leu Ile Arg Val Ser Pro 
465                 470                 475                 480 


Ile Pro Asn Thr Asp Glu Leu Gly Tyr Ala Lys Gly Gly Ser Lys Ile 
                485                 490                 495     


Ile Ile Lys Glu Trp Thr Asn Thr Thr Ile Pro Gly Ile Gln Val Gly 
            500                 505                 510         


Pro Asn Gly Ile Leu Lys Lys His Leu Met Asn Gly Ser Ser Val Leu 
        515                 520                 525             


Leu Ala Pro Gln Ser Met Leu Gln Leu Gly Glu Leu Asp Pro Ser Phe 
    530                 535                 540                 


Ser Arg Arg Ile Asp Val Asn His Ile Lys Trp Thr Glu Asp Thr Gly 
545                 550                 555                 560 


Ala Glu Thr Leu Ser Glu Glu Glu Leu Ile Pro Leu Lys Asn Gly Ser 
                565                 570                 575     


Ile Ile Arg His Asn Ala Met Asp Trp Ile Glu Met Trp Val His Glu 
            580                 585                 590         


Val Gly Asp Val Val Ser Gly Trp Ser Ser Gly Ile Gln Ala Val Ile 
        595                 600                 605             


Ser Ile Phe Phe Ile Phe Val Phe Val Ala Ala Leu Tyr Lys Leu Thr 
    610                 615                 620                 


Gln Ile Cys Ile Arg Ile Lys Arg Arg Ile His Pro Ser Lys Lys Lys 
625                 630                 635                 640 


Ile Gln Ser Pro Asp Pro Glu Ala Asp Ala Asp Leu Ile Gly Ser Lys 
                645                 650                 655     


Pro Glu Arg Asp Asn Arg Asn Gln Thr Val Phe Gly 
            660                 665             


<210>  462
<211>  591
<212>  PRT
<213>  Bahia barhavirus

<400>  462

Met Ile Ser Asn Met Phe Phe Leu Phe Gln Leu Ser Leu Phe Leu Gln 
1               5                   10                  15      


Phe Ile Ala Gly Asp Glu Ser Leu Glu Thr Ile Thr Ala Pro Glu Thr 
            20                  25                  30          


Pro Asp Pro Ile Leu Leu Lys Gly Asp Thr Lys Tyr Leu Phe Leu Val 
        35                  40                  45              


Pro Ser Ser Val Lys Asn Trp Lys Pro Ala Asp Leu Asn Glu Leu Thr 
    50                  55                  60                  


Cys Pro Pro Leu Ile Ser Lys Pro Asp Thr Ser Glu Met Thr Tyr Phe 
65                  70                  75                  80  


Ser Thr Asp Val Met Glu Leu Gln Lys His His Glu Leu Ala Pro Val 
                85                  90                  95      


Glu Gly Tyr Leu Cys Ser Gly Leu Arg Tyr Lys Val Ile Cys Ser Glu 
            100                 105                 110         


Gly Phe Phe Gly Gln Lys Thr Ile Ala Lys Lys Ile Glu Asn Ile Glu 
        115                 120                 125             


Pro Asp Ser Lys Gln Cys Leu Asp Asp Leu Ser Lys Phe Lys Asn Asp 
    130                 135                 140                 


Asp Tyr Leu Leu Pro Tyr Phe Pro Ser Glu Asp Cys Asn Trp Met Lys 
145                 150                 155                 160 


Glu Thr Pro Thr His Lys Asp Phe Ile Val Phe Gln Lys His Phe Val 
                165                 170                 175     


Lys Tyr Asp Pro Tyr Asn Asn Gly Phe Tyr Asp Pro Leu Leu Lys Lys 
            180                 185                 190         


Asp Tyr Cys Asp Thr Gln Val Cys Glu Thr Glu His Asp Gln Thr Ile 
        195                 200                 205             


Trp Ile Thr Glu Lys Ser Ile Glu Asn Glu Cys Ile Phe Asn Tyr Pro 
    210                 215                 220                 


Ile Lys Lys His Ile Phe His Thr Ala Asp Phe Gly Lys Met Ile Ile 
225                 230                 235                 240 


Asp Tyr Glu Leu Asn Gln Trp Thr Ser Val Glu Asp Gly Cys Leu Ile 
                245                 250                 255     


Asn Tyr Cys Gly Arg Glu Gly Ile Arg Leu Ser Asn Gly Met Phe Phe 
            260                 265                 270         


Val Gly Lys Phe Tyr Lys Asn Leu Asn Asn Leu Gln Thr Cys Ser Ala 
        275                 280                 285             


Gly Thr Lys Val Ser Tyr Lys Pro Leu Thr Ser Lys Leu Glu Glu Ile 
    290                 295                 300                 


Glu Asn Glu Ile Ile Leu Asp Gln Glu Arg Leu Leu Cys Leu Asp Ser 
305                 310                 315                 320 


Ile Arg Gln Met Thr Ala Thr Lys Lys Leu Ser Phe Tyr Ser Leu Ser 
                325                 330                 335     


Phe Leu Glu Pro Lys Ser Ser Ser Arg His Lys Val Phe Arg Ile His 
            340                 345                 350         


Asn Lys Thr Leu Glu Tyr Thr Glu Thr Glu Trp His Pro Ile Met Ser 
        355                 360                 365             


Phe Asn Phe Asp Glu Pro Asn Lys Ile Gly Ile Asp Lys Asn Gly Lys 
    370                 375                 380                 


Ser Val Tyr Trp Asn Glu Trp Val Pro Ser Gly Ile Ser Gly Leu Leu 
385                 390                 395                 400 


Ser Gly Phe Asn Gly Val Tyr Lys Lys Glu Asn Glu Thr Lys Val Thr 
                405                 410                 415     


Ile Ala Arg Leu Glu Thr Ile Lys Glu Asp Tyr Asp Arg Glu Met Met 
            420                 425                 430         


Ile Asp His Glu Leu Val Glu Val Glu His Pro Lys Ile Val His Leu 
        435                 440                 445             


Lys Arg Glu Asn Ile Thr Gly Ser Arg Val Glu Ile Val Asn Lys Glu 
    450                 455                 460                 


His Ser Asp Val Ser Gly Trp Leu Ser Ser Val Leu Ser Ser Phe Trp 
465                 470                 475                 480 


Gly Lys Ile Met Met Thr Ile Ile Ser Ile Ile Leu Ile Val Ile Ile 
                485                 490                 495     


Gly Leu Val Leu Ile Asn Cys Cys Pro Ile Ile Cys Lys Ser Cys Ile 
            500                 505                 510         


Lys Arg Tyr Lys Thr Lys Glu Glu Ser Arg Asn Arg His Arg Leu Asp 
        515                 520                 525             


Arg Glu Asp Asn Gly Arg Leu Arg Arg Gln His Arg Val Ile Phe Asn 
    530                 535                 540                 


Asn Gln Ser Asn Asp Glu Glu Asn Ala Ile Glu Met Val Glu Tyr Thr 
545                 550                 555                 560 


Asp Thr Pro Arg Pro Leu Arg Pro Ile Pro Asp Ala Thr Thr Ser Asp 
                565                 570                 575     


Thr Glu Ser Arg Ser Pro Thr Thr Ala His Ser Phe Phe Asn Arg 
            580                 585                 590     


<210>  463
<211>  537
<212>  PRT
<213>  Muir barhavirus

<400>  463

Met Lys Ser Val Phe Phe Phe Phe Val Ile Leu Phe Asn Thr Met Asp 
1               5                   10                  15      


Ala Asp Leu Ser Ile Pro Leu Gly Asn Thr Asn Asn Leu Pro Gly Leu 
            20                  25                  30          


Thr Thr Pro Leu Glu Pro Ile Val Glu Gly Arg Ser Arg Thr Ser Arg 
        35                  40                  45              


Lys Glu Lys Asp Phe Gly Glu Met Thr Val Leu Pro Leu Arg Arg Leu 
    50                  55                  60                  


Glu Pro Trp Arg Glu Cys Ala Ile Ala Asp Leu Gln Cys Pro Pro Arg 
65                  70                  75                  80  


Tyr Asp Phe Gly Glu Lys Ile Gly Ser Leu Ile Thr Thr Glu Lys Leu 
                85                  90                  95      


Trp Pro Val Arg Gly Leu Ser Val Leu Gln Glu Gly Tyr Phe Cys Thr 
            100                 105                 110         


Lys Thr Ser Arg Asp Arg Thr Cys Ser Thr Ser Phe Phe Gly Ser Glu 
        115                 120                 125             


Asp Leu Ser Gly Ser Glu Glu Tyr Leu Tyr Pro Asn Asp Ser Asp Cys 
    130                 135                 140                 


Leu Lys Glu Val Lys Ser Leu Glu Ser Gly Arg Tyr Ser Pro Pro Val 
145                 150                 155                 160 


Trp Pro Glu His Thr Cys Ala Trp Met Ala Thr Arg Thr Val Thr Leu 
                165                 170                 175     


Val Gln Tyr Gln Leu Asn Leu His Asn Val Leu Trp Glu Asp Ile Gly 
            180                 185                 190         


Gly Thr Tyr His Asp Ala Lys Leu Lys Gly Gly Lys Cys Ser Thr Arg 
        195                 200                 205             


Ile Cys Ser Thr Asn Asn Pro Gly Val Leu Trp Ile Arg Gly Lys Lys 
    210                 215                 220                 


Ala Asn His Leu Leu Arg Pro Glu Asp Arg Leu Pro Cys Lys Ile Tyr 
225                 230                 235                 240 


Glu Asn Lys Thr Ser Ser Ile Leu Gln Val His Cys Asp Tyr His His 
                245                 250                 255     


Pro Leu His Phe Lys Val Gly Ala Cys Lys Phe Ser Tyr Arg Gly Glu 
            260                 265                 270         


Ser Gly Ile Arg Ser Glu Glu Gly Val Gly Leu Ala Trp Asp Leu Lys 
        275                 280                 285             


Lys Gly Ser Lys Ile Ala Arg Tyr Val Gly Pro Glu Cys Asp Lys Lys 
    290                 295                 300                 


Lys Thr Pro Ile Tyr Gln Trp Ser Ala Asn Ser Lys Phe Arg Tyr Asp 
305                 310                 315                 320 


Ala Ala Thr Lys Ala Asp Asp Asp Leu His Ala Arg Cys Leu Asp Ala 
                325                 330                 335     


Leu Val Arg Ile Arg Glu His Lys Asp Ile Ser Gln Trp Asp Leu Gly 
            340                 345                 350         


Tyr Phe Tyr Pro Ser Ser Pro Gly Pro Phe Pro Ala Tyr Arg Leu Asn 
        355                 360                 365             


Lys Ser Ser Lys Val Leu Glu Cys Ser Lys Tyr Leu Phe Thr Leu Lys 
    370                 375                 380                 


Glu Val Lys Ser Gly Arg Ser Leu Val Asp Tyr Leu Pro Glu Glu Ser 
385                 390                 395                 400 


Ile Ile Pro Asp Pro Arg Thr Gly Glu Lys Leu Gly Val Ser Gly Leu 
                405                 410                 415     


Ile Val Lys Asn Asp Ser Ser Val Tyr Val Pro His Gln Arg Ser Asn 
            420                 425                 430         


Gln Met Ile Ser Trp Glu His His Leu Gly Pro Lys Asp Lys Val Glu 
        435                 440                 445             


Ile Ser Arg Met Ser Leu Thr Pro Asn Val Asp Asp Asn Thr Leu Leu 
    450                 455                 460                 


Phe Ser Glu Asp Pro Gln Asn His Ala Thr Glu Asn Gly Thr Ser Gln 
465                 470                 475                 480 


Ala Thr Phe Leu Ser His Leu Gly Phe Gly Ile Glu His Leu Phe Tyr 
                485                 490                 495     


Thr Leu Leu Gly Leu Ser Ile Ala Gly Leu Val Gly Val Cys Val Val 
            500                 505                 510         


Lys Val Cys Leu Glu Asn Ala Phe Lys Cys Gly Cys Lys Tyr Cys Ser 
        515                 520                 525             


Arg Ser Asp Leu Asp Asp Tyr Ser His 
    530                 535         


<210>  464
<211>  537
<212>  PRT
<213>  Caligus caligrhavirus

<400>  464

Met Lys Ser Val Phe Phe Phe Phe Val Ile Leu Phe Asn Thr Met Asp 
1               5                   10                  15      


Ala Asp Leu Ser Ile Pro Leu Gly Asn Thr Asn Asn Leu Pro Gly Leu 
            20                  25                  30          


Thr Thr Pro Leu Glu Pro Ile Val Glu Gly Arg Ser Arg Thr Ser Arg 
        35                  40                  45              


Lys Glu Lys Asp Phe Gly Glu Met Thr Val Leu Pro Leu Arg Arg Leu 
    50                  55                  60                  


Glu Pro Trp Arg Glu Cys Ala Ile Ala Asp Leu Gln Cys Pro Pro Arg 
65                  70                  75                  80  


Tyr Asp Phe Gly Glu Lys Ile Gly Ser Leu Ile Thr Thr Glu Lys Leu 
                85                  90                  95      


Trp Pro Val Arg Gly Leu Ser Val Leu Gln Glu Gly Tyr Phe Cys Thr 
            100                 105                 110         


Lys Thr Ser Arg Asp Arg Thr Cys Ser Thr Ser Phe Phe Gly Ser Glu 
        115                 120                 125             


Asp Leu Ser Gly Ser Glu Glu Tyr Leu Tyr Pro Asn Asp Ser Asp Cys 
    130                 135                 140                 


Leu Lys Glu Val Lys Ser Leu Glu Ser Gly Arg Tyr Ser Pro Pro Val 
145                 150                 155                 160 


Trp Pro Glu His Thr Cys Ala Trp Met Ala Thr Arg Thr Val Thr Leu 
                165                 170                 175     


Val Gln Tyr Gln Leu Asn Leu His Asn Val Leu Trp Glu Asp Ile Gly 
            180                 185                 190         


Gly Thr Tyr His Asp Ala Lys Leu Lys Gly Gly Lys Cys Ser Thr Arg 
        195                 200                 205             


Ile Cys Ser Thr Asn Asn Pro Gly Val Leu Trp Ile Arg Gly Lys Lys 
    210                 215                 220                 


Ala Asn His Leu Leu Arg Pro Glu Asp Arg Leu Pro Cys Lys Ile Tyr 
225                 230                 235                 240 


Glu Asn Lys Thr Ser Ser Ile Leu Gln Val His Cys Asp Tyr His His 
                245                 250                 255     


Pro Leu His Phe Lys Val Gly Ala Cys Lys Phe Ser Tyr Arg Gly Glu 
            260                 265                 270         


Ser Gly Ile Arg Ser Glu Glu Gly Val Gly Leu Ala Trp Asp Leu Lys 
        275                 280                 285             


Lys Gly Ser Lys Ile Ala Arg Tyr Val Gly Pro Glu Cys Asp Lys Lys 
    290                 295                 300                 


Lys Thr Pro Ile Tyr Gln Trp Ser Ala Asn Ser Lys Phe Arg Tyr Asp 
305                 310                 315                 320 


Ala Ala Thr Lys Ala Asp Asp Asp Leu His Ala Arg Cys Leu Asp Ala 
                325                 330                 335     


Leu Val Arg Ile Arg Glu His Lys Asp Ile Ser Gln Trp Asp Leu Gly 
            340                 345                 350         


Tyr Phe Tyr Pro Ser Ser Pro Gly Pro Phe Pro Ala Tyr Arg Leu Asn 
        355                 360                 365             


Lys Ser Ser Lys Val Leu Glu Cys Ser Lys Tyr Leu Phe Thr Leu Lys 
    370                 375                 380                 


Glu Val Lys Ser Gly Arg Ser Leu Val Asp Tyr Leu Pro Glu Glu Ser 
385                 390                 395                 400 


Ile Ile Pro Asp Pro Arg Thr Gly Glu Lys Leu Gly Val Ser Gly Leu 
                405                 410                 415     


Ile Val Lys Asn Asp Ser Ser Val Tyr Val Pro His Gln Arg Ser Asn 
            420                 425                 430         


Gln Met Ile Ser Trp Glu His His Leu Gly Pro Lys Asp Lys Val Glu 
        435                 440                 445             


Ile Ser Arg Met Ser Leu Thr Pro Asn Val Asp Asp Asn Thr Leu Leu 
    450                 455                 460                 


Phe Ser Glu Asp Pro Gln Asn His Ala Thr Glu Asn Gly Thr Ser Gln 
465                 470                 475                 480 


Ala Thr Phe Leu Ser His Leu Gly Phe Gly Ile Glu His Leu Phe Tyr 
                485                 490                 495     


Thr Leu Leu Gly Leu Ser Ile Ala Gly Leu Val Gly Val Cys Val Val 
            500                 505                 510         


Lys Val Cys Leu Glu Asn Ala Phe Lys Cys Gly Cys Lys Tyr Cys Ser 
        515                 520                 525             


Arg Ser Asp Leu Asp Asp Tyr Ser His 
    530                 535         


<210>  465
<211>  542
<212>  PRT
<213>  Lepeophtheirus caligrhavirus

<400>  465

Met Val Gln Leu Val Leu Gln Ser Phe Trp Thr Ala Leu Ile Leu Asn 
1               5                   10                  15      


Leu Ser Ile Pro Pro Ser Ser Gly Asp Ile Gln Asp Asn Thr Ile Glu 
            20                  25                  30          


Trp Arg His Pro Val Phe Ser Val Pro Asp Lys Gly Val Glu Val Asn 
        35                  40                  45              


Leu Met Ile His Gly Pro Ile Lys Tyr Pro Trp Lys Thr Cys Ser Arg 
    50                  55                  60                  


Glu Ser Phe Val Cys Pro Pro Thr Val His Asp Gly Ile Glu Glu Gly 
65                  70                  75                  80  


Leu Ile Lys Glu Ile Leu Asp Leu Glu Val Pro Asp Asn Leu Asp Lys 
                85                  90                  95      


Ala Val Ile Asp Gly Tyr Leu Cys His Lys Ile Arg Arg Arg Thr Ile 
            100                 105                 110         


Cys Glu Thr Ser Phe Phe Gly His Gln Thr Ile Thr Tyr His Arg Tyr 
        115                 120                 125             


Arg Leu Val Ile Thr Lys Asp Asn Cys Arg Glu Val Met Arg Glu Tyr 
    130                 135                 140                 


Glu Glu Gly Ser Tyr Glu Pro Ser Gly Gln Pro Asp Pro Glu Cys Ala 
145                 150                 155                 160 


Trp Met Ser Thr Asp Val Ser Asp Val Asp Ile Met Glu Ile Thr Pro 
                165                 170                 175     


His Pro Val Phe Phe Asn Pro Phe Asp Ser Ser Met Glu Asp Ala Val 
            180                 185                 190         


Ile Lys Gly Phe Cys Lys Gly Glu Phe Cys Gln Thr His Arg Glu Gly 
        195                 200                 205             


Thr Leu Trp Ile Arg Lys Ser Ser Ser Lys Pro Ala Leu Asp Tyr Lys 
    210                 215                 220                 


Lys Val Ser Cys Asn Phe Phe Arg Gly Glu Glu Ile Thr Asp His Leu 
225                 230                 235                 240 


Lys Trp Leu Ile Lys Cys Pro Arg Phe Pro Tyr Phe Lys Val Asn Lys 
                245                 250                 255     


Arg Thr Cys Arg Thr Ile Leu Asp Gly Lys Ser Ala Leu Gly Asn Pro 
            260                 265                 270         


Asp Gly Leu Ile Ile Ile Thr Asp Leu Gly Lys Lys Gly Pro Leu Pro 
        275                 280                 285             


Thr Cys Ser Lys Lys Val Lys Phe Gly Leu Leu Lys Ser Ser Gly Gln 
    290                 295                 300                 


Ile Gln Ser Gly Leu Glu Glu Ile Lys Asp Asp Phe Leu Tyr Glu Arg 
305                 310                 315                 320 


Cys Ile Asp Ser Leu Ser Arg Ile Val His Gln Ser Ser Val Asn Phe 
                325                 330                 335     


Arg Asp Leu Gly Phe Phe Tyr Pro Arg Ser Pro Gly Leu His Pro Leu 
            340                 345                 350         


Tyr Met Leu Lys Asp Lys Lys Ile Trp Cys Asn Arg Ala Leu Phe Glu 
        355                 360                 365             


Glu Lys Lys Val Thr Leu Asp Asp Lys Ser Leu Glu Lys Thr Phe Val 
    370                 375                 380                 


His Tyr Ser Trp Met Arg Trp Lys Asn Thr Ser Leu Tyr Gln Ser Ala 
385                 390                 395                 400 


Asn Gly Val Thr Trp Asn Lys Glu Thr Asn Ser Ser Asp Ser Gly Thr 
                405                 410                 415     


Lys Tyr His Ile Pro His Leu Met Glu Met Ser Ala Ser Leu Ala Ile 
            420                 425                 430         


Thr His Thr Arg Gly His Ser Val Ala Tyr Pro Arg Thr Phe His Ile 
        435                 440                 445             


Arg Gln Asn Met Asp Asp Pro Leu Thr Asp Val Asp Thr His Val Gln 
    450                 455                 460                 


Lys Arg His Pro Leu Gly Glu Asn Phe Ala Lys Trp Trp Asp Asn Leu 
465                 470                 475                 480 


Gly Glu Val Val Lys Gly Val Ile Ser Thr Ile Thr Thr Leu Ile Val 
                485                 490                 495     


Ile Leu Val Ser Leu Phe Ile Val Trp Val Leu Val Phe Cys Leu Lys 
            500                 505                 510         


Lys Ile Gly Gly Gly Cys Arg Glu Asn Val Asn Glu Leu Ser Lys Pro 
        515                 520                 525             


Asn Asn Glu Phe Gly Met Asp Ser Trp Gly Ser Gln Leu Pro 
    530                 535                 540         


<210>  466
<211>  532
<212>  PRT
<213>  Salmonlouse caligrhavirus

<400>  466

Met Leu Thr Arg Thr Ala Arg Thr Thr Ser Thr Ser Leu Phe Ile Lys 
1               5                   10                  15      


Leu Ser Ile Leu Cys Val Leu Thr Asp His Ile Thr Ser Gly Asp Lys 
            20                  25                  30          


Asn Gly Thr Thr Asp Glu Lys Lys Ser His Phe Val Tyr Pro Ser Arg 
        35                  40                  45              


Ile Val Gly Ser Leu Leu Pro Cys Leu Pro Glu Asp Leu Val Cys Pro 
    50                  55                  60                  


Pro Thr Val Lys Asp Tyr Ala Thr Val Gly Leu Thr Pro Thr Lys Lys 
65                  70                  75                  80  


Lys Leu Leu Met Pro Ala Gly Gly Lys Thr Glu His Val Gly Gly Val 
                85                  90                  95      


Leu Cys His Leu Val Lys Lys Arg Thr Thr Cys Trp Thr Ser Leu Trp 
            100                 105                 110         


Gly Ser Asn Asp Ile Ser Gln Gln Glu Tyr Arg Thr Pro Val Val Leu 
        115                 120                 125             


Asp Arg Cys Arg Leu Ala Val Asn Asn Tyr Leu Arg Gly Glu His Glu 
    130                 135                 140                 


Asn Val Glu Phe Pro Glu Ser Glu Cys Ser Trp Met Ser Thr Ile Asp 
145                 150                 155                 160 


Met Asp Ile Thr Gly Ala Ile Ile Thr Pro His Glu Thr Phe Phe Asp 
                165                 170                 175     


Pro Tyr Lys Thr Ser Val Tyr Asp Lys His Leu Ile Arg Ser Cys Arg 
            180                 185                 190         


Asn Arg Val Cys Glu Thr Val Arg Arg Asp Leu Val Trp Phe Ala Leu 
        195                 200                 205             


Glu Glu Phe Pro Leu Pro Ser Asp Leu Phe Gln Lys Gln Asp Cys Ile 
    210                 215                 220                 


Ile Tyr Ser Ser Asp Pro Asp Asn Glu Ala Thr Leu Ile Lys Cys Glu 
225                 230                 235                 240 


Gly Tyr Pro Tyr Leu Thr Ile Ser Asn Gln Ser Cys Gln Ile Asn Tyr 
                245                 250                 255     


Gly Gly Arg Thr Gly Val Ala Thr Pro His His Phe Ala Ile Phe Gly 
            260                 265                 270         


Asn Ile Pro Gly His Asp Ser Leu Pro Pro Cys Ser Asp Asn Val Ile 
        275                 280                 285             


Ile Gly Val Thr Gly Pro Met Glu Lys Ser Ile Glu Arg Arg Gly Glu 
    290                 295                 300                 


Tyr Ala Asp Met Asn Leu Arg Glu Arg Cys Leu Asp Ala Ile Asp Arg 
305                 310                 315                 320 


Ile Thr Asn Glu Asn Thr Val Thr Leu Arg Thr Leu Gly His Phe Met 
                325                 330                 335     


Pro Arg Ser Pro Gly Arg His Pro Val Tyr Ile Leu Ile Asn Ser Thr 
            340                 345                 350         


Leu Met Cys Gly Ser Ala Lys Tyr Lys Glu Tyr Thr Gly Ser Leu Asp 
        355                 360                 365             


Asn Asp Asn Leu Trp Thr Leu Leu Lys Asn Ser Leu Trp Val His Trp 
    370                 375                 380                 


Ala Asp Asp Asn His Leu Ser Tyr Asn Gly Val Leu Arg Tyr Gly Lys 
385                 390                 395                 400 


Glu Ser Gln Pro Glu Ile His Ile Pro His Leu Asn Asp Ile Arg Asp 
                405                 410                 415     


Ser Leu Val Ala Leu His Thr Glu Glu Leu Glu Leu Ile Pro Thr Asn 
            420                 425                 430         


Arg Val Val Phe Ile Pro Asp Lys Glu Val Pro Leu Asn Ala Ser Ile 
        435                 440                 445             


Pro Thr Gln Arg Lys Thr Thr Lys Ile Gly Gly Asp Leu Gly Thr Ser 
    450                 455                 460                 


Phe Asn Ala Ile Gly Ser Trp Phe Gln Thr Asn Met Ser Leu Leu Ile 
465                 470                 475                 480 


Thr Leu Gly Thr Gly Met Ala Leu Leu Gly Leu Gly Tyr Val Leu Leu 
                485                 490                 495     


Met Ile Val Leu Lys Cys Ile Lys Gly Leu Lys Lys Pro Pro Lys Ser 
            500                 505                 510         


Asp Ser Ile Asn Leu Asn Leu Gln Pro Phe Gln Pro Ser Gly Lys Asp 
        515                 520                 525             


Arg Ala Glu His 
    530         


<210>  467
<211>  820
<212>  PRT
<213>  Curionopolis curiovirus

<400>  467

Met Asp Leu Val Arg Phe Ser Ile Ala Leu Ser Val Phe Leu Cys Tyr 
1               5                   10                  15      


Gly Thr Pro Pro Ser Gln Gly Gln Ala Ile Val Ser Ile Lys Asp Ser 
            20                  25                  30          


Cys Glu Ala Lys Ser Ala Pro Trp Ile Pro Cys Glu Lys Phe Asp Tyr 
        35                  40                  45              


Val Lys Asn Ala Thr Gly Ser Gly Ile Lys Cys Trp Ile Phe Cys Ser 
    50                  55                  60                  


Arg Ser Gly Phe Tyr Ser Lys Thr Gly Arg Phe Ile Arg Cys Ile Gln 
65                  70                  75                  80  


Gly Asp Pro Glu Ala Lys Tyr Ile Lys Ser Cys Arg Arg Gln Ile Glu 
                85                  90                  95      


Lys Arg Gly Lys Glu Lys Met Arg Glu Gly Thr Arg Gly Lys Arg Lys 
            100                 105                 110         


Thr Ser Glu Pro Lys Glu Glu Gly Val Arg Ala Lys Thr Asp Phe Thr 
        115                 120                 125             


Pro Asp Glu Ser Arg Arg Leu Asn Asn Leu Thr Lys Val Phe Arg Lys 
    130                 135                 140                 


Val Glu Asp Lys Asp Leu Asn Asp Phe Lys Lys Phe Ile Leu Glu Lys 
145                 150                 155                 160 


Gly Leu Glu Thr Lys Ile Lys Leu Ala Asn Asp Gly Lys Ile Ser Phe 
                165                 170                 175     


Arg Asp Pro Asp Cys Gly Glu Asn Lys Asp Tyr Pro Cys His Arg Ile 
            180                 185                 190         


His Gln Ile Ile Glu Gly Val Asn Glu Asn Ile Asp Tyr Ile Asn Glu 
        195                 200                 205             


Ile Leu Ser Leu Lys Lys Met Lys Glu Glu Leu Arg Leu Arg Glu Arg 
    210                 215                 220                 


Glu Ser Glu Glu Gly Glu Phe Pro Gly Leu Leu Asn Thr Thr Asn Arg 
225                 230                 235                 240 


Arg Gly Phe Leu Leu His Tyr Pro Val Glu Leu Gly Asn Trp Ser Arg 
                245                 250                 255     


Leu Glu Asp Pro Ser Gln Ile Lys Cys Pro Ser His His Lys Asp Met 
            260                 265                 270         


Leu Ser Asn Pro Arg Arg Leu Gly Lys Tyr Asn Leu Asp Ile Ile Val 
        275                 280                 285             


Arg Arg Pro Arg Ile Gly Thr Phe Glu Thr Val Val Pro Gly Tyr Ile 
    290                 295                 300                 


Cys Gln Gly Met Gln Trp Thr Ser Thr Cys Asn Glu Met Trp Tyr Phe 
305                 310                 315                 320 


Val Thr Tyr His Asp Arg Ala Val His Tyr Ile Thr Pro Asn Lys Leu 
                325                 330                 335     


Lys Cys Leu Gln Asn Ile Arg Ala His Lys Arg Gly Glu His Ile Lys 
            340                 345                 350         


Pro Tyr Tyr Pro Leu Glu Glu Cys Asn Trp Asn Ser Glu Thr Thr Lys 
        355                 360                 365             


Thr Val Asp Tyr Phe Met Ile Thr Pro Tyr Ser Pro Glu Val Asp Pro 
    370                 375                 380                 


Phe Thr Leu Glu Phe Lys Ser Glu Ile Phe Pro Asp Arg Thr Ser Cys 
385                 390                 395                 400 


Arg Pro Gly Asp Glu Ile Cys Val Thr Asp Asp Asp Ser Lys Val Trp 
                405                 410                 415     


Phe Pro Asp Glu Asp Asp Lys Leu Ile Ala Arg Gly His Cys Pro Asp 
            420                 425                 430         


Glu Thr Trp Asp Glu Ser His Leu Thr Ile His Pro Glu Glu Met Pro 
        435                 440                 445             


Glu Asn Trp Glu Asp Pro Gln Ser Pro Trp Val Ser Asp Tyr Ile Leu 
    450                 455                 460                 


Lys Gly Val Leu Phe Gly Glu Lys Arg Val Lys Lys Ser Cys Leu Leu 
465                 470                 475                 480 


Glu Phe Cys Gly Thr Ser Gly Leu Leu Phe Glu Asp Gly Glu Trp Trp 
                485                 490                 495     


Glu Leu Asn Val Phe Ser Arg Glu Lys Gly Arg Glu Ser Leu Thr Lys 
            500                 505                 510         


Ile Phe Ile Glu Gln Glu Glu Ile Arg Arg Cys Asn Gly Thr Glu Thr 
        515                 520                 525             


Arg Val Gly Val Ala Gly Lys Glu Thr Asp Glu Lys Ala Leu Leu Asn 
    530                 535                 540                 


Ala Val Leu Ser Lys Asn Ala Tyr Glu Arg Cys Lys Ser Ala Arg Tyr 
545                 550                 555                 560 


Arg Leu Ile Glu Asn Lys Tyr Leu Arg Leu Asp Asp Leu Ser Tyr Ile 
                565                 570                 575     


Asn Pro Arg Glu Ser Val Thr Trp Trp Ala Tyr Arg Val Arg Ala Gly 
            580                 585                 590         


Asp Asp Glu Arg Thr Phe Lys Leu Glu Lys Thr Thr Gly Glu Tyr Arg 
        595                 600                 605             


Tyr Leu Gln Val Pro Pro Ser Leu Glu Gln His Val Thr Asp Cys Asp 
    610                 615                 620                 


Gly Gln Glu Asn Cys Ser Val Ser Ile Gly Tyr Tyr Arg Gly Glu Leu 
625                 630                 635                 640 


Ile Asn Ser Ser Asp Trp Thr Arg Thr Gly His Asp Asp Val Tyr Val 
                645                 650                 655     


Gly Val Asn Gly Leu Leu Arg Lys Asp Thr Gly Asn Lys Thr Ile Val 
            660                 665                 670         


Leu Tyr Pro Pro Leu Met Lys Glu Tyr Gln Glu Ile Phe Ser Asp Ser 
        675                 680                 685             


Gly Glu Ser Asp Asp Glu Ala Phe Ile Tyr Lys Pro Asp Ile His Glu 
    690                 695                 700                 


Lys Lys Gly Lys Pro Lys Glu Ala Glu Asp Glu Lys Asp Glu Lys Ser 
705                 710                 715                 720 


Lys Lys Asn Lys Thr Pro Ile Asp Asp Ile Lys Asp Trp Trp Ser Asn 
                725                 730                 735     


Ile Lys Gly Glu Trp His Leu Ile Lys Gly Ile Leu Ile Gly Leu Phe 
            740                 745                 750         


Thr Phe Ala Leu Leu Ile Gly Val Val Lys Leu Gly Val Phe Ile Lys 
        755                 760                 765             


Ser Ser Phe Arg Lys Arg Arg Asp Asp Ser Ile Pro Glu Gly Lys Asp 
    770                 775                 780                 


Glu Glu Ile Gly Ile Lys Met Gln Ser Arg Arg Ser Arg Gln Asn Ile 
785                 790                 795                 800 


Tyr Glu Glu Ile Asn Glu Val Ser Pro Thr Met Thr Arg Arg Gly Arg 
                805                 810                 815     


Asn Ile Phe Asn 
            820 


<210>  468
<211>  818
<212>  PRT
<213>  Iriri curiovirus

<400>  468

Met Lys Lys Thr Met Glu Thr Ile Lys Asn Phe Ile Leu Ile Leu Ser 
1               5                   10                  15      


Val Ala Val Gln Leu Asp Thr Gly His Gly Met Glu Phe Ala Leu Ile 
            20                  25                  30          


Arg Asn Thr Cys Asp Thr Arg Ser Met Lys Gln Val Pro Cys Gln His 
        35                  40                  45              


Leu Ile Ser Val Arg Glu Ser Thr Gly Pro Lys Gly Lys Cys Leu Ile 
    50                  55                  60                  


Phe Cys Ala Lys Glu Lys Arg Arg Trp Ala Glu Gly Val Glu Ser Gln 
65                  70                  75                  80  


Cys Leu Gln Gly Asp Pro Thr Ser Pro Gln Val Val Lys Cys Lys Glu 
                85                  90                  95      


Arg Ile Glu Lys Gly Leu Glu Arg Leu Thr Val Leu Thr Ser Ser Lys 
            100                 105                 110         


Arg Lys Arg Met Arg Glu Pro Phe Arg Ala Arg Gly Asn Gln Thr Lys 
        115                 120                 125             


Glu Glu Gly Gly Arg Leu Ile Arg Ile Ser Asp Val Leu Lys Arg Ile 
    130                 135                 140                 


Asp His Lys Asp Leu Glu Gln Phe Lys Lys Asp Val Leu Glu Lys Asn 
145                 150                 155                 160 


Val Glu Thr Phe Leu Tyr Val Asn Ser Ser Asn Leu Ile Asp Met His 
                165                 170                 175     


Lys Asn Tyr Ser Cys Ser Pro Pro Asp Gly Phe Glu Cys Tyr Ser Ile 
            180                 185                 190         


Lys Arg Ala Ile Asp Asp Ser Asn Glu Lys Val Leu Tyr Val Gln Lys 
        195                 200                 205             


Ala Gln Lys Glu Lys Asp Lys Ser Thr Trp Ser Lys Asp Leu Leu Ser 
    210                 215                 220                 


Asp Ala Tyr Arg Arg Glu Glu Gly Thr Ile Glu Thr Ala Thr Glu Arg 
225                 230                 235                 240 


Gly Phe Leu Ile His Tyr Pro Ile Glu Ser Arg Asp Trp Ser Asn Leu 
                245                 250                 255     


Thr Asp Pro Ser Gln Ile Lys Cys Pro Ser His Gln Gly Asp Arg Leu 
            260                 265                 270         


Arg Lys Ser Gly Thr Leu Arg Asn Val Asp Leu Glu Ile Ile Val Arg 
        275                 280                 285             


Arg Pro Arg Pro Gly Asn Phe Lys Thr Ala Val Pro Gly Tyr Ile Cys 
    290                 295                 300                 


Gln Gly Met Gln Trp Thr Ser Thr Cys Asn Glu Met Trp Tyr Phe Val 
305                 310                 315                 320 


Thr Tyr His Asp Arg Ala Val Lys Thr Ile Thr Pro Asn Glu Val Lys 
                325                 330                 335     


Cys Leu Gln Asn Ile Gln Ser His Lys Arg Gly Glu Asp Val Arg Pro 
            340                 345                 350         


Tyr Tyr Pro Leu Glu Glu Cys Asn Trp Asn Ala Glu Thr Thr Lys Thr 
        355                 360                 365             


Val Asp Tyr His Met Ile Thr Pro Tyr Ser Pro Leu Val Asp Pro Phe 
    370                 375                 380                 


Thr Leu Glu Phe Lys Ser Glu Ile Phe Leu Glu Ser Ser Ser Cys Ser 
385                 390                 395                 400 


Pro Gly Asp Lys Phe Cys Leu Thr Asp Asp Thr Ser Arg Ile Trp Phe 
                405                 410                 415     


Pro Asp Gln Asp Asp Pro Leu Ile Ala Leu Gly His Cys Gln Asp Thr 
            420                 425                 430         


Thr Trp Asp Glu Ser Phe Leu Thr Val His Pro Glu Glu Ile Pro Arg 
        435                 440                 445             


Asn Trp Ser Asp Pro Asn Ser Thr Trp Thr Asn Asp Leu Ile Leu Lys 
    450                 455                 460                 


Gly Ile Leu Phe Gly Glu Lys Arg Val Ser Lys Ser Cys Ile Leu Glu 
465                 470                 475                 480 


Phe Cys Gly Glu Leu Gly Leu Leu Phe Glu Asp Gly Glu Trp Trp Glu 
                485                 490                 495     


Ile Asn Val Phe Ser Lys Glu Gln His Arg Ser Arg Leu Thr Lys Gln 
            500                 505                 510         


Phe Leu Glu Glu Glu Lys Leu Glu Arg Cys Thr Gly Thr Glu Ser Arg 
        515                 520                 525             


Ile Gly Val Val Gly Lys Glu Thr Asp Glu Lys Ala Leu Leu Asp Ala 
    530                 535                 540                 


Ala Leu Arg Arg Ser Gly Tyr Glu Lys Cys Lys Ala Ala Arg Tyr Arg 
545                 550                 555                 560 


Leu Ile Glu Asn Arg Asn Leu Arg Leu Asp Asp Leu Ser Tyr Ile Asn 
                565                 570                 575     


Pro Arg Asp Ser Val Asn Trp Trp Ser Tyr Arg Val Arg Ala Glu Asp 
            580                 585                 590         


Ser Asp Arg Leu Phe Arg Leu Glu Lys Ala Ile Ser Leu Tyr Arg Leu 
        595                 600                 605             


Val Gln Val Thr Pro Lys Leu Leu Lys Gly Gly Gln Val Cys Glu Asp 
    610                 615                 620                 


Lys Arg Asn Cys Ser Leu Ile Ile Gly Tyr His Lys Gly Lys Glu Ile 
625                 630                 635                 640 


Lys Ser Ser Asp Trp Glu Glu Thr Gly His Asp Gly Val Tyr Ile Gly 
                645                 650                 655     


Val Asn Gly Leu Ile Arg Arg Asp Thr Arg Asn Val Ser Tyr Ile Tyr 
            660                 665                 670         


Tyr Pro Pro Leu Ile Lys Glu Tyr Glu Glu Met Phe Ser Asp Ser Gly 
        675                 680                 685             


Glu Ile Glu Asp Glu Ala Phe Ile Phe Gln Pro Glu Ile His Ser Lys 
    690                 695                 700                 


Lys Thr Lys Pro Lys Ser Asp Asp Gln Asp Ser Ser Thr Asp Ser Lys 
705                 710                 715                 720 


Lys Asn Lys Thr Pro Ile Asp Asp Leu Glu Asp Trp Trp Lys Lys Leu 
                725                 730                 735     


Lys Ser Glu Trp Gly Ala Ile Lys Gly Thr Leu Ile Gly Val Thr Leu 
            740                 745                 750         


Ile Val Gly Leu Ile Leu Leu Leu Lys Leu Ile Leu Ala Val Lys Arg 
        755                 760                 765             


Leu Ile Ser Arg Lys Arg Gly Lys Lys Ser Glu Ala Gly Lys Glu Glu 
    770                 775                 780                 


Lys Glu Lys Glu Met Val Arg Phe Arg Ala Thr Pro Asn Ile Tyr Glu 
785                 790                 795                 800 


Glu Ile Asp Glu Arg Ser Pro Thr Arg Pro Arg Gly Arg Arg Thr Ile 
                805                 810                 815     


Phe Thr 
        


<210>  469
<211>  784
<212>  PRT
<213>  Itacaiunas curiovirus

<400>  469

Met Lys Asp Leu His Thr Leu Val Leu Leu Val Val Leu Ile Lys Leu 
1               5                   10                  15      


Tyr Lys Gly Gly Ser Ser Val His Thr Pro Met Thr Arg Cys Thr Val 
            20                  25                  30          


Tyr Ala Pro Gln Gln Arg Ile Gln Cys Asn Arg Phe Asp Lys Val Phe 
        35                  40                  45              


Arg Ile Arg Gly Gly Gly Val Gly Ile Ile Leu Cys Arg Arg Ser Gln 
    50                  55                  60                  


Lys Phe Asp Pro Asn Leu Cys Thr Cys Phe Arg Asp Thr Asn Pro Gly 
65                  70                  75                  80  


Ala Leu Ser Cys Tyr Lys Leu Met Thr Ser Lys Gly Ser Phe Pro Ser 
                85                  90                  95      


Glu Lys Glu Ser Arg Gly Asp Glu Lys Pro Gln Glu Ser Gly Thr Leu 
            100                 105                 110         


Ala Asp Tyr Leu Asn Val Thr Phe Leu Glu Lys Thr Gly Lys Leu Gly 
        115                 120                 125             


Ala Lys Lys Gly Glu Asp Pro Asp Glu Ser Arg Leu Leu Asp Ala Ala 
    130                 135                 140                 


Ile Lys Ser Gly Gly Leu Gly Val Asp Phe Asn Gly His Leu Lys Ile 
145                 150                 155                 160 


Leu Asn Glu Glu Ser Leu Thr Ser Asn Leu Asn Glu Thr Asp Val Asn 
                165                 170                 175     


Arg Ile Lys Gly Leu Leu Thr Ser Trp Asn Lys Asp Arg Leu Gly Gly 
            180                 185                 190         


Gln Pro Gly Glu Tyr Asp Pro Asn Lys Trp Lys Lys Asp Ala Lys Glu 
        195                 200                 205             


Met Thr Glu Glu Asp Glu Asn Ser Glu Arg His Arg Val Asn Ser Thr 
    210                 215                 220                 


Arg Leu Arg Met Ile Phe His Pro Glu Gly Pro Tyr Asn Trp Thr Ala 
225                 230                 235                 240 


Val Thr Asp Pro Gln Arg Ile Arg Cys Pro Arg Pro Arg Leu Tyr Ser 
                245                 250                 255     


Lys Ser Val Asp His Asn Phe Arg Gly Val Ala Lys Arg Pro Arg Val 
            260                 265                 270         


Thr Glu Thr Ser Leu Val Arg Gly Tyr Ile Cys Glu Ala His Arg Trp 
        275                 280                 285             


Val Ser Glu Cys Glu Glu Met Trp Tyr Phe Ser Lys Tyr Tyr Thr Arg 
    290                 295                 300                 


Glu Ile Gln Thr Thr Val Pro Glu Val Leu Ala Cys Ile Lys Ala Ile 
305                 310                 315                 320 


Lys Asp Leu Lys Ser Gly Glu Pro Glu Ile Pro Thr Phe Pro Leu Ser 
                325                 330                 335     


Leu Cys Asn Trp Asn Ser Lys Thr Ser Gln Gly Val Ile Phe His Thr 
            340                 345                 350         


Ala Thr Pro Val Asp Ile Leu Leu Asp Pro Phe Ser Met Thr Tyr Lys 
        355                 360                 365             


Ser Thr Leu Phe Pro Glu Lys Trp Pro Cys Asn Ala His Ala Leu Tyr 
    370                 375                 380                 


Cys Leu Thr Ser Lys Pro Trp Arg Lys Trp Phe Pro Asp Glu Glu Leu 
385                 390                 395                 400 


Thr Arg Leu Ser Pro Gln Leu Cys Lys Thr Thr Ser Trp Glu Ala Phe 
                405                 410                 415     


Pro Phe Phe Gly Asp Val Ile Asp Leu Pro Ser Lys Pro Arg Asp Pro 
            420                 425                 430         


Ser Ser Leu Trp Thr Pro His Val Leu Val Glu Asn Glu Ile Phe Gly 
        435                 440                 445             


Gln Lys Asn Leu Asn Asp Gly Cys Leu Met Asp Phe Cys Gly Glu Thr 
    450                 455                 460                 


Gly Val Lys Phe Pro Asp Gly Glu Trp Trp Leu Phe Ser Val Leu His 
465                 470                 475                 480 


Gly Pro Arg Gly Gly Leu Lys Asn Leu Thr Ser Ala Leu Ser Arg Cys 
                485                 490                 495     


Lys Asn Ser Ser Ser Leu His Gln Ile Ala Glu Val Phe Pro Asn Leu 
            500                 505                 510         


Glu Asp Ser Gly Arg Arg Leu Glu Leu Thr Ser Arg Glu Arg Tyr Glu 
        515                 520                 525             


Arg Cys Leu Asp Val Lys Asp Lys Leu Thr Ala Gly Tyr Phe Met Asn 
    530                 535                 540                 


Pro Thr Asp Leu Gly Tyr Ile Gly Gln His Gln Glu Gly Pro Gly Thr 
545                 550                 555                 560 


Ala Tyr Arg Leu Lys Arg Leu Gly Thr Asn Lys Thr Gly Gln Leu Ile 
                565                 570                 575     


Leu Met Glu Ser Pro Ala Val Tyr Arg Val Leu Ile His Lys Glu Asp 
            580                 585                 590         


Tyr Asp Glu Glu Gly Phe Arg Val Trp Glu Asn Ser Asn Ser Ser Trp 
        595                 600                 605             


Asn Glu Ser Gly Lys Leu Ser Val Gln Phe Gly Ile Thr Ser Lys Gly 
    610                 615                 620                 


Leu Lys Phe Glu Ala Glu Trp Thr Ser Leu Lys Ser Glu Gly Arg Trp 
625                 630                 635                 640 


Val Gly Val Asn Gly Ile Leu Leu Leu Lys Gly Glu Lys Pro Gly Thr 
                645                 650                 655     


Trp Val Ile Ser Val Pro Asp Ser Arg Gln Asp Leu Glu Asp Ile Leu 
            660                 665                 670         


Ser Trp Glu His Leu Glu Gly Glu Arg Val Val Tyr Asp Glu Arg Val 
        675                 680                 685             


Ile Leu Thr Ser Ser Asp Ile Glu Leu Asp Asp Leu Gly Asn Thr Leu 
    690                 695                 700                 


Asp Thr Glu Val Glu Thr Lys Asn Ile Phe Ser Gly Ile Ile Lys Trp 
705                 710                 715                 720 


Phe Asp Ser Val Tyr Ser Ser Val Ser Ser Tyr Ile Tyr Ile Ile Gly 
                725                 730                 735     


Val Leu Val Ala Val Gly Leu Gly Ile Trp Ile Leu Thr Lys Ala Lys 
            740                 745                 750         


Arg Phe Ile Val Arg Asp Arg Ser Pro Gly Asn Gln Thr Ser Glu Ile 
        755                 760                 765             


Thr Ile Pro Met Asn Arg Asn Arg Arg Glu Asp Gln Arg Ser Tyr Ile 
    770                 775                 780                 


<210>  470
<211>  758
<212>  PRT
<213>  Rochambeau curiovirus

<400>  470

Met Lys Lys Thr Met Glu Leu Ile Lys Val Ile Pro Val Ala Cys Leu 
1               5                   10                  15      


Leu Tyr Ile Phe Leu Ser Arg His Ile Leu Val Gly Gln Cys Lys Asp 
            20                  25                  30          


Lys Ile Gln Thr Gly Lys Asn Thr Ser Pro Pro Lys Ser Arg Asn Phe 
        35                  40                  45              


Lys Gly Ser Pro Pro Asp Ser Asp Ser Val Leu Ala Lys Thr Asn Leu 
    50                  55                  60                  


Thr Gln Glu Glu Ser Lys Arg Leu Ser Asn Ile Ser Gln Val Leu Glu 
65                  70                  75                  80  


Lys Ile Glu Asp Arg Asp Leu Ala Glu Phe Lys Arg Ile Ile Leu Asp 
                85                  90                  95      


Lys Asn Leu Glu Lys Ser Leu Ser Glu Asp Lys Asp Gly Lys Ile His 
            100                 105                 110         


Leu Asn Ala Pro Lys Cys Gly Glu Asn Asp Ser Tyr Arg Cys His Arg 
        115                 120                 125             


Val Asn Lys Ile Leu Glu Asn Val Asn Asp Asn Ile Asp His Leu Asn 
    130                 135                 140                 


Asp Leu Leu Arg Lys Ser Ser Gly Ser Asn Leu Arg Glu Lys Leu Arg 
145                 150                 155                 160 


Glu Leu Asp Asp Ser Ser Glu Gly Gly Gly Lys Gly Ser Lys Ser Asp 
                165                 170                 175     


Gly His Gly Ser Phe Leu Leu His Tyr Pro Ile Thr Val Gly Asn Trp 
            180                 185                 190         


Ser Glu Leu Glu Asp Pro Thr Leu Ile Lys Cys Pro Ser His His Arg 
        195                 200                 205             


Asn Gln Ile Gly His Ser Gly Ser Asp Arg Arg Leu Asp Leu Asp Ile 
    210                 215                 220                 


Ile Ala Arg Arg Pro Arg Thr Ser Thr Phe Gln Thr Ser Val Pro Gly 
225                 230                 235                 240 


Tyr Ile Cys His Gly Met Arg Trp Thr Ser Ser Cys Asn Glu Met Trp 
                245                 250                 255     


Tyr Phe Val Thr Tyr His Asp Arg Ala Val Thr Ser Ile Thr Pro Asn 
            260                 265                 270         


Lys Leu Lys Cys Ile Gln Asn Ile Gln Ala Trp Lys Arg Gly Glu His 
        275                 280                 285             


Val Lys Pro Tyr Tyr Pro Leu Glu Glu Cys Asn Trp Asn Ala Glu Thr 
    290                 295                 300                 


Thr Lys Thr Val Asp Tyr His Met Ile Ile Pro Tyr Ser Leu Arg Val 
305                 310                 315                 320 


Asp Pro Leu Ser Leu Gln Phe Glu Gly Glu Ile Phe Leu Asp Ser Gln 
                325                 330                 335     


Ser Cys Lys Pro Gly Asp Ser Leu Cys Phe Thr Asp Asp Asn Ser Lys 
            340                 345                 350         


Ile Trp Phe Pro Asp Asp Asp Asp Lys Leu Val Ala Thr Gly His Cys 
        355                 360                 365             


Pro Asp Glu Ser Trp Asp Glu Ser Ser Leu Thr Ile His Pro Glu Lys 
    370                 375                 380                 


Met Pro Asn Asp Trp Ser Asn Glu Asn Thr Ser Trp Ser Gln Asp Tyr 
385                 390                 395                 400 


Ile Leu Lys Gly Ile Leu Phe Gly Glu Lys Arg Val Arg Arg Ser Cys 
                405                 410                 415     


Leu Leu Glu Phe Cys Gly Ala Met Gly Leu Leu Phe Glu Asp Gly Glu 
            420                 425                 430         


Trp Trp Glu Ile Ser Val Tyr Ser Ala Asp Ser Lys Arg Glu Ser Leu 
        435                 440                 445             


Thr Lys Leu Phe Leu Lys Glu Glu Gly Ile Asn Arg Cys Asn Gly Thr 
    450                 455                 460                 


Glu Glu Arg Ile Gly Val Ala Gly Lys Glu Thr Asp Glu Lys Ala Leu 
465                 470                 475                 480 


Leu Asp Ala Val Leu Arg Lys Thr Gly Tyr Glu Lys Cys Lys Ala Ala 
                485                 490                 495     


Arg Tyr Arg Leu Thr Glu Asn Lys His Leu Arg Leu Asp Asp Leu Ser 
            500                 505                 510         


Tyr Ile Asn Pro Arg Asp Ser Val Met Trp Pro Ala Tyr Arg Val Arg 
        515                 520                 525             


Arg Gln Ser Glu Gly Ser Glu Lys Tyr Phe Ser Leu Glu Thr Ala Met 
    530                 535                 540                 


Ser Glu Tyr Gly Met Val Gln Val Thr Arg Ser Leu Gln Met Leu Gly 
545                 550                 555                 560 


Gln Lys Cys Tyr Gly Val Glu Asn Cys Ser Met Ile Val Gly Tyr Asn 
                565                 570                 575     


Leu Gly Lys Glu Ile Arg Ser Asp Asp Trp Thr Pro Ser Gly His Pro 
            580                 585                 590         


Gly Val Tyr Val Gly Ile Asn Gly Leu Ile Arg Lys Asp Asp Glu Asn 
        595                 600                 605             


Thr Ser Arg Ile Tyr Tyr Pro Pro Leu Ser Lys Glu Tyr Glu Ser Val 
    610                 615                 620                 


Phe Ser Asp Ser Gly Glu Met Glu Asp Glu Ala Tyr Ile Tyr Lys Pro 
625                 630                 635                 640 


Glu Ile Lys His Lys Gly Asn Val Asn Pro Lys Lys Asp Asp Glu Asp 
                645                 650                 655     


Ser Ser Glu Glu Glu Lys Lys Asn Lys Thr Pro Leu Asp Asp Leu Ser 
            660                 665                 670         


Asp Trp Trp Lys Lys Leu Lys Gly Glu Trp Lys Leu Ile Lys Gly Ile 
        675                 680                 685             


Ile Val Ser Phe Leu Val Phe Leu Gly Leu Tyr Leu Ile Ile Lys Cys 
    690                 695                 700                 


Cys Leu Lys Leu Arg Ser Val Ile Lys Glu Lys Lys Ile Lys Lys Val 
705                 710                 715                 720 


Val Asp Glu Glu Lys Ser Leu Glu Leu Lys Glu Arg Arg Ala Glu Pro 
                725                 730                 735     


Asn Ile Tyr Glu Glu Ile Asn Glu Thr Ser Arg Pro Arg Val Arg Arg 
            740                 745                 750         


Gly Arg Asn Tyr Phe Asn 
        755             


<210>  471
<211>  660
<212>  PRT
<213>  Adelaide River ephemerovirus

<400>  471

Met Ala Thr Phe Lys Val Leu Val Leu Met Ile Leu Trp Ile Thr Ser 
1               5                   10                  15      


Ile Phe Asn Val Arg Cys Glu Lys Phe Val Thr Ile Pro Val Asn Cys 
            20                  25                  30          


Ser Gly Glu Val Asp Ile Asp Lys Met Asp Val Met Cys Pro Asn Arg 
        35                  40                  45              


Tyr Asn Leu Leu Ser Thr Asn His Leu Met Glu Gly Glu Glu Val Glu 
    50                  55                  60                  


Thr Phe Cys Arg Pro Ser Leu Arg Glu Asn Asp Leu Leu Asp Gly Tyr 
65                  70                  75                  80  


Leu Cys Arg Lys Gln Lys Trp Glu Val Thr Cys Thr Glu Thr Trp Tyr 
                85                  90                  95      


Phe Val Thr Asp Val Lys Tyr Gln Ile Ile Glu Val Ile Pro Thr Glu 
            100                 105                 110         


Asn Glu Cys Met Glu Glu Arg Glu Arg Lys Leu Lys Gly Glu Tyr Ile 
        115                 120                 125             


Pro Pro Tyr Tyr Pro Pro Thr Asn Cys Val Trp Asn Ala Ile Asp Thr 
    130                 135                 140                 


Gln Glu Arg Thr Phe Ile Thr Leu Ile Glu His Pro Val Ile Glu Asp 
145                 150                 155                 160 


Pro Val Thr Met Thr Leu Met Asp Ser Lys Phe Thr Lys Pro Cys Asn 
                165                 170                 175     


Pro Lys His Asn Glu Val Thr Ile Cys Asp Thr Tyr Asn Pro Leu Ile 
            180                 185                 190         


Lys Trp Ile Ser Lys Glu Thr Ser Gly Leu Asn Leu His Cys Gln Ile 
        195                 200                 205             


Lys Ser Trp Glu Cys Ile Pro Val Lys Leu His His Ser His Arg Asn 
    210                 215                 220                 


Met Met Glu Ala Leu Tyr Leu Glu Ser Pro Asp Phe Gly Ile Val Asp 
225                 230                 235                 240 


Ala Ser Lys Ile Cys Asn Leu Thr Phe Cys Gly Tyr Asn Gly Ile Leu 
                245                 250                 255     


Leu Asp Asn Gly Glu Trp Trp Ser Ile Tyr Arg Ser Gly Phe Thr His 
            260                 265                 270         


Gly Phe Leu Asp Asn His Ile Leu Lys Asn Arg Arg Ile Glu Glu Cys 
        275                 280                 285             


Lys Glu Lys Lys Pro Gly Tyr Lys Leu Ala Lys Leu Asp Thr Thr Tyr 
    290                 295                 300                 


Ile Asp Leu Glu Phe Glu Ile Glu Leu Glu His Glu Lys Cys Leu Gly 
305                 310                 315                 320 


Thr Leu Glu Lys Leu Gln Asn Gly Glu Tyr Val Thr Pro Leu Asp Leu 
                325                 330                 335     


Ser Tyr Leu Ser Pro Ser Asn Pro Gly Lys His Tyr Ala Tyr Arg Leu 
            340                 345                 350         


Glu Tyr Ile Asn Thr Thr Glu His Lys Cys Val Gln Leu Gly Phe Thr 
        355                 360                 365             


Tyr Glu Gly Gly Asp Cys Arg Lys Met Leu Asp Glu Arg Asp Asp His 
    370                 375                 380                 


Gly Ala Tyr Tyr Asn Trp Thr Thr Ile Lys Leu Gln Arg Val Ile Arg 
385                 390                 395                 400 


Ala Val Cys Tyr Tyr His Thr Phe Ser Met Asn Leu Asp Glu Ser Lys 
                405                 410                 415     


His Lys Tyr Tyr Asp Gln Asp Asn Arg Ser Ile Gln Ile Asp Glu Lys 
            420                 425                 430         


Phe Ile Ser Glu Val Leu Lys Ser Thr Pro Leu Ile Asp Arg His Glu 
        435                 440                 445             


Lys Tyr Glu Gly Asn Leu Ser Trp Asn Gly Ile Ile Ile Glu Ser Lys 
    450                 455                 460                 


Asn Gly His Glu Lys Asn Val Ile Val Pro Ser Ala Ser Gln Tyr Asn 
465                 470                 475                 480 


His Val Met Ile Asn Lys Ile Leu Lys Arg Leu Asp Thr Val Met Tyr 
                485                 490                 495     


Asp Ser Tyr Lys Phe Asp Ser Glu Ser Gly Ser Ile Ser Tyr Asn Lys 
            500                 505                 510         


Ile Val Pro Ile Val Arg Glu Asp Asn Leu Gln Asn Ala His Arg Val 
        515                 520                 525             


Asp Val Ile Gln Tyr Ile Lys Asp Lys Gly Ser Tyr Ile Ile Asn Gly 
    530                 535                 540                 


Phe Thr Gly Trp Phe Ser Ser Leu Gly Lys Leu Met Arg Trp Thr Ile 
545                 550                 555                 560 


Trp Gly Val Gly Leu Phe Phe Ser Ile Phe Thr Leu Tyr Lys Ile Ile 
                565                 570                 575     


Met Ile Leu Arg Lys His Ser Asn Asp Asn Val Arg Lys Glu Phe Lys 
            580                 585                 590         


Glu Thr Ala Gly Lys Val Met Ile Gly Gln Pro Ile Asp Thr Lys Ser 
        595                 600                 605             


Met Ser Arg Thr Ser Ile Lys Ala Asn Asn Lys Gly Lys Phe Asp Lys 
    610                 615                 620                 


Val Lys Asp Leu Phe Thr Pro Arg Ser Lys Thr Ile Ser His Leu Thr 
625                 630                 635                 640 


Thr Asp Thr Leu Lys Glu His Thr Asp Gly Thr Tyr Glu Glu Leu His 
                645                 650                 655     


Phe Phe Asn Val 
            660 


<210>  472
<211>  623
<212>  PRT
<213>  Berrimah ephemerovirus

<400>  472

Met Phe Arg Val Leu Ala Trp Ile Ile Leu Ile Lys Leu Thr Ser Gly 
1               5                   10                  15      


Ser Lys Ile Tyr Asn Ile Pro Val Asn Cys Gly Arg Leu Glu Ser Val 
            20                  25                  30          


Lys Leu His Glu Ile Lys Cys Pro Gln Arg Val Asn Glu Leu Ser Leu 
        35                  40                  45              


Gln Ala His His Gln Leu Ala Lys Glu Glu His Tyr Asn Lys Ile Cys 
    50                  55                  60                  


Arg Pro Gln Leu Lys Asp Asp Asp His Leu Glu Gly Phe Ile Cys Arg 
65                  70                  75                  80  


Lys Gln Lys Trp Ile Thr Lys Cys Thr Glu Thr Trp Tyr Phe Ser Thr 
                85                  90                  95      


Ser Ile Glu Tyr Gln Ile Leu Glu Val Ile Pro Glu Phe Ser Gly Cys 
            100                 105                 110         


Asn Asp Ala Val Lys Lys Leu Asp Gln Gly Ala Leu Ile Pro Pro Tyr 
        115                 120                 125             


Tyr Pro Pro Ala Gly Cys Phe Trp Asn Ala Glu Met Glu Gln Glu Ile 
    130                 135                 140                 


Glu Phe Tyr Ile Leu Ile Gln His Lys Pro Phe Leu Asn Pro Tyr Asp 
145                 150                 155                 160 


Asn Met Ile Tyr Asp Ser Arg Phe Leu Lys Pro Cys Thr Ile Glu Asp 
                165                 170                 175     


Ser Lys Lys Leu Gly Cys Gln Leu Lys Asp Ile Thr Gly Thr Trp Val 
            180                 185                 190         


Pro Asp Ile Arg Val Lys Glu Val Ser Glu His Cys Asn His Gln His 
        195                 200                 205             


Trp Glu Cys Ile Thr Val Lys Ser Phe Lys Ser Glu Leu Asn Glu Lys 
    210                 215                 220                 


Glu Arg Leu Trp Glu Ala Pro Asp Ile Gly Leu Val His Ile Asn Lys 
225                 230                 235                 240 


Gly Cys Leu Ser Lys Phe Cys Gly Arg Asp Gly Ile Ile Phe Ala Asp 
                245                 250                 255     


Gly Glu Trp Trp Ser Ile Glu Asn Lys Thr Asn Glu Asp Val Gln Asn 
            260                 265                 270         


Phe Glu Ile Arg Glu Cys Val Gly Lys Lys Pro Gly Phe Arg Met His 
        275                 280                 285             


Thr Asp Arg Thr Glu Phe Glu Glu Leu Asp Ile Lys Ala Glu Leu Glu 
    290                 295                 300                 


His Glu Arg Cys Leu Asn Thr Ile Ser Lys Ile Leu Asn Arg Glu Asn 
305                 310                 315                 320 


Ile Asn Thr Leu Asp Met Ser Tyr Leu Ala Pro Thr Arg Pro Gly Arg 
                325                 330                 335     


Asp Tyr Ala Tyr Leu Phe Lys Gln Thr Lys Trp Gln Glu Lys Leu Cys 
            340                 345                 350         


Leu Ser Leu Ser Ser Ser Leu Gly Val Ile Lys Asn Cys Ser Ile Asn 
        355                 360                 365             


Trp Lys Ser Ser Thr Lys Gly Gly Met Val Lys Lys Asp His Val Gly 
    370                 375                 380                 


Ile Gly Ser Tyr Glu Arg Thr Met Cys Glu Tyr Arg Pro Phe Ile Asp 
385                 390                 395                 400 


Glu Asn Glu Asp Gly Tyr Ile Glu Met Gly Glu Leu Lys Gly His Lys 
                405                 410                 415     


Met Ser Ser His His Thr Met Leu Glu Leu Pro Pro Ser Gly Gly Ser 
            420                 425                 430         


Gln Asn Gln Lys Ile Asn Val Thr Leu Asn Gly Met Ile Phe Val Gly 
        435                 440                 445             


Glu Asn Lys Leu Tyr Leu Gln Thr Lys Ser Ala Tyr Asp Gly Ile Glu 
    450                 455                 460                 


Glu Tyr Gln Lys Leu Ile Lys Phe Glu Val Gln Glu Tyr Asp Asn Ile 
465                 470                 475                 480 


Glu Glu Asn Leu Ile Lys Tyr Glu Glu Asp Glu Lys Val Glu Ser Ile 
                485                 490                 495     


Asn Leu Thr Pro His Glu Asn Lys Asn Val Ser Arg Thr Asp Ile Val 
            500                 505                 510         


Arg Glu Ile Gln Arg Gly Gly Arg Arg Val Leu Ser Ala Val Ala Gly 
        515                 520                 525             


Trp Phe Thr Ser Thr Ala Lys Ala Val Arg Trp Thr Ile Trp Ala Val 
    530                 535                 540                 


Gly Ala Ile Val Thr Thr Tyr Ala Ile Tyr Lys Leu Tyr Lys Met Val 
545                 550                 555                 560 


Lys Asn Asn Ser Lys Ser Lys Asn Thr Glu Asp Ile Glu Ile Glu Ser 
                565                 570                 575     


Leu Lys Pro Gln Pro Arg Lys Glu Val Arg Ser Pro Lys Ile Glu Lys 
            580                 585                 590         


Lys Tyr Gln Asp Ala Glu Ile Gly Leu Tyr Glu Glu Ile Lys Ser Val 
        595                 600                 605             


Lys Ser Asp Asp Lys Tyr Ala Leu Glu Ser Arg Phe Phe Asp His 
    610                 615                 620             


<210>  473
<211>  623
<212>  PRT
<213>  Bovine fever ephemerovirus

<400>  473

Met Phe Lys Val Leu Ile Ile Thr Leu Leu Val Asn Lys Ile His Leu 
1               5                   10                  15      


Glu Lys Ile Tyr Asn Val Pro Val Asn Cys Gly Glu Leu His Pro Val 
            20                  25                  30          


Lys Ala His Glu Ile Lys Cys Pro Gln Arg Leu Asn Glu Leu Ser Leu 
        35                  40                  45              


Gln Ala His His Asn Leu Ala Lys Asp Glu His Tyr Asn Lys Ile Cys 
    50                  55                  60                  


Arg Pro Gln Leu Lys Asp Asp Ala His Leu Glu Gly Phe Ile Cys Arg 
65                  70                  75                  80  


Lys Gln Arg Trp Ile Thr Lys Cys Ser Glu Thr Trp Tyr Phe Ser Thr 
                85                  90                  95      


Ser Ile Glu Tyr Gln Ile Leu Glu Val Ile Pro Glu Tyr Ser Gly Cys 
            100                 105                 110         


Thr Asp Ala Val Lys Lys Leu Asp Gln Gly Ala Leu Ile Pro Pro Tyr 
        115                 120                 125             


Tyr Pro Pro Ala Gly Cys Phe Trp Asn Thr Glu Met Asn Gln Glu Ile 
    130                 135                 140                 


Glu Phe Tyr Val Leu Ile Gln His Lys Pro Phe Leu Asn Pro Tyr Asp 
145                 150                 155                 160 


Asn Leu Ile Tyr Asp Ser Arg Phe Leu Thr Pro Cys Thr Ile Asn Asp 
                165                 170                 175     


Ser Lys Thr Lys Gly Cys Pro Leu Lys Asp Ile Thr Gly Thr Trp Ile 
            180                 185                 190         


Pro Asp Val Arg Val Glu Glu Ile Ser Glu His Cys Asn Asn Lys His 
        195                 200                 205             


Trp Glu Cys Ile Thr Val Lys Ser Phe Arg Ser Glu Leu Asn Asp Lys 
    210                 215                 220                 


Glu Arg Leu Trp Glu Ala Pro Asp Ile Gly Leu Val His Val Asn Lys 
225                 230                 235                 240 


Gly Cys Leu Ser Thr Phe Cys Gly Lys Asn Gly Ile Ile Phe Glu Asp 
                245                 250                 255     


Gly Glu Trp Trp Ser Ile Glu Asn Gln Thr Glu Ser Asp Phe Gln Asn 
            260                 265                 270         


Phe Lys Ile Glu Lys Cys Lys Gly Lys Lys Pro Gly Phe Arg Met His 
        275                 280                 285             


Thr Asp Arg Thr Glu Phe Glu Glu Leu Asp Ile Lys Ala Glu Leu Glu 
    290                 295                 300                 


His Glu Arg Cys Leu Asn Thr Ile Ser Lys Ile Leu Asn Lys Glu Asn 
305                 310                 315                 320 


Ile Asn Thr Leu Asp Met Ser Tyr Leu Ala Pro Thr Arg Pro Gly Arg 
                325                 330                 335     


Asp Tyr Ala Tyr Leu Phe Glu Gln Thr Ser Trp Gln Glu Lys Leu Cys 
            340                 345                 350         


Leu Ser Leu Pro Asp Ser Gly Arg Val Ser Lys Asp Cys Asn Ile Asp 
        355                 360                 365             


Trp Arg Thr Ser Thr Arg Gly Gly Met Val Lys Lys Asn His Tyr Gly 
    370                 375                 380                 


Ile Gly Ser Tyr Lys Arg Ala Trp Cys Glu Tyr Arg Pro Phe Val Asp 
385                 390                 395                 400 


Lys Asn Glu Asp Gly Tyr Ile Asp Ile Gln Glu Leu Asn Gly His Asn 
                405                 410                 415     


Met Ser Gly Asn His Ala Ile Leu Glu Thr Ala Pro Ala Gly Gly Ser 
            420                 425                 430         


Ser Gly Asn Arg Leu Asn Val Thr Leu Asn Gly Met Ile Phe Val Glu 
        435                 440                 445             


Pro Thr Lys Leu Tyr Leu His Thr Lys Ser Leu Tyr Glu Gly Ile Glu 
    450                 455                 460                 


Asp Tyr Gln Lys Leu Ile Lys Phe Glu Val Met Glu Tyr Asp Asn Val 
465                 470                 475                 480 


Glu Glu Asn Leu Ile Arg Tyr Glu Glu Asp Glu Lys Phe Lys Pro Val 
                485                 490                 495     


Asn Leu Asn Pro His Glu Lys Ser Gln Ile Asn Arg Thr Asp Ile Val 
            500                 505                 510         


Arg Glu Ile Gln Lys Gly Gly Lys Lys Val Leu Ser Ala Val Val Gly 
        515                 520                 525             


Trp Phe Thr Ser Thr Ala Lys Ala Val Arg Trp Thr Ile Trp Ala Val 
    530                 535                 540                 


Gly Ala Ile Val Thr Thr Tyr Ala Ile Tyr Lys Leu Tyr Lys Met Val 
545                 550                 555                 560 


Lys Ser Asn Ser Ser His Ser Lys His Arg Glu Ala Asp Leu Glu Gly 
                565                 570                 575     


Leu Gln Ser Thr Thr Lys Glu Asn Met Arg Val Glu Lys Asn Asp Lys 
            580                 585                 590         


Asn Tyr Gln Asp Leu Glu Leu Gly Leu Tyr Glu Glu Ile Arg Ser Ile 
        595                 600                 605             


Lys Gly Gly Ser Lys Gln Thr Gly Asp Asp Arg Phe Phe Asp His 
    610                 615                 620             


<210>  474
<211>  649
<212>  PRT
<213>  Hayes ephemerovirus

<400>  474

Met Ile Ser Lys Ile Leu Cys Trp Met Ala Leu Gly Gln Cys Leu Arg 
1               5                   10                  15      


Val Thr Arg Ala Glu Thr Glu Ser Arg Val Phe Asn Val Pro Val Asn 
            20                  25                  30          


Cys Met Glu Glu Arg Pro Ile Lys Pro Thr Glu Ile Val Cys Pro Lys 
        35                  40                  45              


Arg Tyr Asn Glu Leu Ser Leu Glu Ala His His Thr Leu Ile Glu Gly 
    50                  55                  60                  


Glu Glu Lys Ile Glu Gln Ile Cys Arg Pro Ala Leu Arg Asp Asp Asp 
65                  70                  75                  80  


His Val Asp Gly Tyr Ile Cys Arg Glu Gln His Trp Glu Thr Glu Cys 
                85                  90                  95      


Glu Glu Thr Trp Tyr Phe Ala Thr Val Ile Asn Tyr His Ile Arg Glu 
            100                 105                 110         


Thr Ile Pro Ser Pro Gly Asp Cys Ile Ser Ala Val Lys Gln Phe Lys 
        115                 120                 125             


Asp Gly Val Leu Ile Pro Pro Tyr Tyr Pro Pro Ala Gly Cys Phe Trp 
    130                 135                 140                 


Asn Thr Lys Ile Lys Glu Thr Ile Lys Phe Met Val Leu Thr Arg His 
145                 150                 155                 160 


Lys Ser Ile Leu Asn Pro Met Asp Asn Leu Val His Asp Ser Gln Phe 
                165                 170                 175     


Ile Asn Pro Cys Asp Leu Lys Lys Thr Gln Lys Thr Gly Cys Lys Leu 
            180                 185                 190         


Lys Asp Val Thr Gly Leu Trp Ile Pro Glu Ile Glu Ile Gly Leu Ser 
        195                 200                 205             


Ser Glu His Cys Ser Arg Lys His Trp Glu Cys Ile Gly Ile Lys Ser 
    210                 215                 220                 


Tyr Lys Ser Glu Leu Asp Glu Lys Ile Arg Ile Trp Glu Ala Pro Glu 
225                 230                 235                 240 


Ile Gly Ile Ile Asn Ile Thr Lys Ser Cys Lys Gln Ser Phe Cys Gly 
                245                 250                 255     


Phe Lys Gly Val Val Phe Asp Asp Gly Glu Trp Trp Gly Tyr Ala Asn 
            260                 265                 270         


Thr Thr Glu Asp Glu Leu Ile Lys Ala His Val Ser Asp Cys Lys Asp 
        275                 280                 285             


Arg Lys Pro Gly Ile Arg Val His Asn Asp His Thr Asp Tyr Glu Thr 
    290                 295                 300                 


Tyr Asp Ile Arg Ala Glu Met Glu Asn Glu Arg Cys Gln Asn Thr Ile 
305                 310                 315                 320 


Ser Lys Ile Leu Asn Ser Glu Pro Ile Asn Thr Val Asp Met Ser Tyr 
                325                 330                 335     


Leu Ser Pro Thr Arg Pro Gly Arg Asp Tyr Ala Tyr Arg Phe Lys Gln 
            340                 345                 350         


Val Asn Trp Thr Glu Thr Phe Cys Leu Arg Trp Val Gln Thr Gly Leu 
        355                 360                 365             


Ser Lys Asp Cys Asn Lys Phe Trp Lys Tyr Ser Asp Arg Gly Gly Lys 
    370                 375                 380                 


Val Thr Lys Asp His Val Gly Ile Gly Glu Tyr Thr Arg Ala Leu Cys 
385                 390                 395                 400 


Glu Phe Arg Pro Ile Ile Asp Lys Asp Gly Asp Gly Tyr Ile Ser Lys 
                405                 410                 415     


Glu Glu Leu Gly Lys His Asn Met Ser Thr Ser Phe Ser Leu Met Arg 
            420                 425                 430         


Leu Asp Lys Lys Gly Gly Asn Gln Gly Ala Asp Ser Ile Glu Val Gly 
        435                 440                 445             


Phe Asn Gly Ile Val Arg Ile Pro Lys Ser Glu Lys Asp Gly Glu Lys 
    450                 455                 460                 


Tyr Met Val Arg Met Thr Ser Val Tyr Asp Gly Leu Glu Gln Arg Asn 
465                 470                 475                 480 


Arg Leu Ile Lys Phe Glu Val Leu Glu Phe Glu Asp Val Val Ala Lys 
                485                 490                 495     


Tyr Gln Gly Glu Gly Asn Tyr Asp Val Asn Asp Lys Val Val Glu Leu 
            500                 505                 510         


Ile Pro Asp Asn Gln Lys Asn Ile Ser Arg Thr Asp Phe Val Arg Thr 
        515                 520                 525             


Ile Ala Asn Gly Gly Lys Glu Ile Ile Ser Gly Ile Val Gly Trp Phe 
    530                 535                 540                 


Thr Gly Thr Ala Lys Ile Ile Arg Trp Thr Ile Trp Ala Ile Gly Ala 
545                 550                 555                 560 


Leu Val Thr Thr Tyr Ala Ile Tyr Lys Leu His Lys Leu Val Arg Gly 
                565                 570                 575     


Lys Asn Lys Gln Glu Ser Gln Asn Tyr Gln Gly Glu Gln Gly Gly Gln 
            580                 585                 590         


Thr Glu Ser Lys Pro Lys Trp Phe Lys Arg Gly Arg Arg Glu Glu Thr 
        595                 600                 605             


Pro Lys Lys Ser Ile Arg Leu Glu Asn Pro Leu Tyr Glu Glu Ile Asp 
    610                 615                 620                 


Ile Asp Asp Asn Tyr Ser Leu Arg His Lys Asp Ser Gly Arg Leu Lys 
625                 630                 635                 640 


Leu Lys Lys Asp Gly Phe Phe Asp Val 
                645                 


<210>  475
<211>  640
<212>  PRT
<213>  Kent ephemerovirus


<220>
<221>  misc_feature
<222>  (633)..(633)
<223>  Xaa can be any naturally occurring amino acid

<400>  475

Met Asn Leu Ile Gln Phe Thr Cys Val Ile Ala Val Ile Glu Ser Ile 
1               5                   10                  15      


Asn Thr Tyr Arg Leu Ala Asn Leu Pro Phe Asp Cys Gln Lys Glu His 
            20                  25                  30          


Glu Ile Pro Val Glu Ala Ile Asp Cys Pro Leu Arg Arg Asn Glu Leu 
        35                  40                  45              


Lys Val Asp His Leu Gln Lys Gly Arg Glu Phe Lys Ile Cys Lys Pro 
    50                  55                  60                  


Lys Leu Ser Glu Asp Asp His Val Lys Gly Lys Leu Cys Arg Ile Gln 
65                  70                  75                  80  


Lys Trp Arg Thr Lys Cys Thr Glu Thr Trp Tyr Phe Thr Thr Phe Ile 
                85                  90                  95      


Glu Tyr Ser Val Val Asp Ile Gln Pro Asn Lys Leu Asp Cys Ala Lys 
            100                 105                 110         


Glu Trp Glu Arg Gln Lys Ala Gly Phe Pro Val Val Pro Phe Phe Pro 
        115                 120                 125             


Pro Ala Val Cys Tyr Trp Asn Ala Ile Asn Glu Ile Ala Glu Thr Tyr 
    130                 135                 140                 


Val Thr Leu Val Asp His Pro Val Leu Glu Asp Pro Tyr Asn Ser Glu 
145                 150                 155                 160 


Val Ile Asp Pro Val Phe Tyr Gly Thr Arg Cys Ser Pro Ile Asn Lys 
                165                 170                 175     


Phe Asp Thr His Trp Phe Cys Lys Ser Thr Asn Asn Leu Ile Leu Trp 
            180                 185                 190         


Met Ser Asp Lys Asp Ser Leu Arg Ser Gln His Cys Asp Ile Arg Thr 
        195                 200                 205             


Trp Asp Cys Ile Thr Val Asn Ser Tyr Val Ser Trp Glu Glu Asp His 
    210                 215                 220                 


Leu Asn His Lys Ile Leu Arg Asn Ser Thr Ile Trp Glu Ala Pro Asp 
225                 230                 235                 240 


Ile Gly Arg Ile Gly Leu Tyr Asp Ala Cys Lys Ile Asp Phe Cys Gly 
                245                 250                 255     


Val Glu Gly Leu Arg Leu Asn Asn Gly Glu Trp Trp Phe Leu Glu Arg 
            260                 265                 270         


Glu Gly Asn Phe Tyr Gly Tyr Asp Tyr His Thr Met Pro Lys Cys Asp 
        275                 280                 285             


Asn Asn Val Lys Ile Gly Val Lys Thr His Val Asp Arg Thr Leu Phe 
    290                 295                 300                 


Glu Glu Ile Asp Ile Lys Leu Glu Leu Glu His Ser Lys Cys Ile Asp 
305                 310                 315                 320 


Thr Ile Ile Lys Met Arg Ser Gly Ile Asp Ile Ser Pro Asp Trp Met 
                325                 330                 335     


Val Leu Asn Ile Pro Ser Asp Pro Gly Lys Asn Tyr Ala Tyr Arg Phe 
            340                 345                 350         


Glu Gln Glu Ser Lys Val Leu Tyr Tyr Cys Tyr Asn Ala Lys Leu Arg 
        355                 360                 365             


Glu Leu Gln Glu Ile Ser Glu Ser Gln Ser Ala Cys Asn Asp Ser Lys 
    370                 375                 380                 


Arg Gln Ile Lys Ile Phe Arg Lys Arg Asp Ile Ala Lys Ile Gly Lys 
385                 390                 395                 400 


Tyr Lys Arg Ala Val Cys Asp Tyr Lys Thr Val Tyr Ile Pro Glu Ile 
                405                 410                 415     


Asp Ser Asn Asp Val Gly Tyr Asn Ile Ser Ser Trp Leu Phe Ala Ile 
            420                 425                 430         


Asp Asn Thr Thr Ile Glu Thr Lys Ile Asn Glu Tyr Lys Trp Ser Asn 
        435                 440                 445             


Leu Thr Gly Asp Gln Asn Asn Gln Tyr Gln Leu Ser Trp Asn Gly Ile 
    450                 455                 460                 


Leu Lys Met Ser Ser Gly Arg Tyr Leu Ile Asn Thr Phe Ser Leu Leu 
465                 470                 475                 480 


Asp Gly Leu Val His Glu Ser Gln Leu Ser Lys Leu Glu Val Arg Ser 
                485                 490                 495     


Phe Glu His Pro Lys Met Asp Lys Asp Ser Leu Tyr Phe His Phe Leu 
            500                 505                 510         


Asn Asp Thr Gly Glu Thr Val Glu Ile Asp Leu Asn Asp Asp Asn Lys 
        515                 520                 525             


Leu Asp Arg Thr Asp Ile Ile Lys Ser Ala Thr Gln Lys Ile Lys Asp 
    530                 535                 540                 


Phe Tyr His Gly Ile Thr Gly Trp Phe Ser Gly Leu Thr Val Met Ile 
545                 550                 555                 560 


Arg Trp Ile Leu Trp Ile Ile Gly Ala Ile Val Thr Ile Tyr Ile Ile 
                565                 570                 575     


Val Lys Leu Lys Arg Lys Val Ser Lys Lys Lys Pro Asp Lys Thr Pro 
            580                 585                 590         


Asp Thr Thr Val Ser Arg Phe Phe Arg Lys Leu Asp Lys Ile Lys Ser 
        595                 600                 605             


Val Pro Ala His Val Val Lys Ser Lys Lys Lys Thr Asn Ser Ser Ser 
    610                 615                 620                 


Gly Asn Lys Ser Thr Asp Asp Thr Xaa Glu Met Ile Asn Phe Tyr Asn 
625                 630                 635                 640 


<210>  476
<211>  435
<212>  PRT
<213>  Kimberley ephemerovirus

<400>  476

Met Lys Ile Glu Lys Ile Cys Arg Pro Gln Ile Lys Asp Asp Asp His 
1               5                   10                  15      


Ile Glu Gly Tyr Ile Cys Arg Glu Gln His Trp Thr Thr Lys Cys Thr 
            20                  25                  30          


Glu Thr Trp Tyr Phe Ser Thr Glu Ile Glu Tyr Thr Ile Lys Glu Thr 
        35                  40                  45              


Val Pro Asn Gln Ala Asp Cys Gln Lys Glu Leu Glu Lys Leu Lys Arg 
    50                  55                  60                  


Gly Ile Ser Ile Pro Pro Tyr Tyr Pro Pro Ala Gly Cys Phe Trp Asn 
65                  70                  75                  80  


Met Ala Gln Ser Glu Lys Ile Thr Phe Val Val Leu Val Pro His Lys 
                85                  90                  95      


Val Leu Gln Asn Pro Tyr Asp Met Lys Leu Tyr Asp Pro Gly Phe Ile 
            100                 105                 110         


Glu Lys Cys Asp Val Glu Lys Ala Lys Thr Lys Gly Cys Lys Met Lys 
        115                 120                 125             


Asp Ile Thr Gly Leu Trp Val Thr Asn Asn Asp Gly Lys Asn Thr Ser 
    130                 135                 140                 


Glu His Cys Asn Lys Asp His Trp Glu Cys Ile Gly Ile Lys Ser Phe 
145                 150                 155                 160 


Arg Ser Glu Leu Asn Leu His Asp Arg Leu Trp Glu Ser Pro Glu Leu 
                165                 170                 175     


Gly Ile Met Lys Leu Asn Lys Ala Cys Lys Lys Asn Phe Cys Gly Tyr 
            180                 185                 190         


Lys Gly Val Ile Leu Glu Asp Gly Glu Trp Trp Gly Tyr Thr Asn Val 
        195                 200                 205             


Ala Asp Asn Glu Ile Glu Tyr Val His Leu Asn Asn Cys Asp Asp Ser 
    210                 215                 220                 


Arg Leu Pro Gly Phe Arg Ile His Gln Asp Arg Thr Glu Phe Glu Glu 
225                 230                 235                 240 


Phe Asp Ile Lys Ala Glu Met Glu Asn Glu Arg Cys Met Asn Thr Leu 
                245                 250                 255     


Ser Lys Ile Leu Asn Lys Glu Asn Leu Asn Phe Val Asp Met Ser Tyr 
            260                 265                 270         


Leu Ser Pro Ser Arg Pro Gly Arg Asp Tyr Ala Tyr Leu Phe Glu Gln 
        275                 280                 285             


Val Ser Trp Asp Glu Thr Phe Cys Leu Thr Trp Pro Asp Ser Arg Lys 
    290                 295                 300                 


Ser Lys Asn Cys Lys Val Asp Trp Lys Val His Lys Asn Ala Gly Leu 
305                 310                 315                 320 


Val Thr Lys Lys His Gly Ala Ile Gly Thr Tyr Tyr Arg Ser Met Cys 
                325                 330                 335     


Met Tyr Tyr Pro Ile Glu Asp Thr Asn Lys Asp Gly Ile Leu Gln Lys 
            340                 345                 350         


Asp Glu Leu Lys Asp Lys Gly Ile Pro Gly Lys Asn Arg Tyr Arg Thr 
        355                 360                 365             


Leu Lys Arg Ser Lys Asn Asp Tyr Gly Glu Asp Ser Glu Phe Asn Ile 
    370                 375                 380                 


Thr Tyr Asn Gly Met Val Val Val Asn Glu Ser Phe His Met Ala Val 
385                 390                 395                 400 


Lys Ser Ile Tyr Asp Gly Thr Glu Asp Tyr Asn Ser Leu Leu Lys Phe 
                405                 410                 415     


Glu Val Ser Glu Phe Asp Lys Ile Asp Leu Asn Glu Ala Tyr Lys Glu 
            420                 425                 430         


Glu Glu Asn 
        435 


<210>  477
<211>  640
<212>  PRT
<213>  Koolpinyah ephemerovirus

<400>  477

Met Lys Ser Leu Thr Arg Thr Thr Leu Ile Leu Ile Leu Phe Gly Gln 
1               5                   10                  15      


Ser Ile Ser Tyr Arg Ile Ala Asn Leu Pro Phe Asp Cys Glu Asn Glu 
            20                  25                  30          


His Glu Ile Pro Val Glu Ala Ile Glu Cys Pro Thr Arg Lys Lys Glu 
        35                  40                  45              


Leu Lys Val Asp His Leu Lys Glu Gly Arg Glu His Arg Ile Cys Lys 
    50                  55                  60                  


Pro Lys Leu Ser Thr Asp Asp His Val Lys Gly Lys Leu Cys Arg Ile 
65                  70                  75                  80  


Gln Lys Trp Lys Thr Lys Cys Thr Glu Thr Trp Tyr Phe Thr Thr Tyr 
                85                  90                  95      


Ile Glu Tyr Glu Val Val Asp Val Met Pro Asn Lys Ile Glu Cys Ala 
            100                 105                 110         


Lys Glu Trp Glu Arg Ala Lys Ala Gly Phe Pro Ile Ile Pro Phe Phe 
        115                 120                 125             


Pro Pro Ala Val Cys Tyr Trp Asn Ala Glu Asn Val Ile Ser Glu Thr 
    130                 135                 140                 


Phe Val Thr Leu Val Asp His Pro Val Leu Gln Asp Pro Tyr Asn Ser 
145                 150                 155                 160 


Glu Val Ile Asp Pro Ile Phe Tyr Gly Thr Arg Cys Ser Pro Ile Asn 
                165                 170                 175     


Asn Phe Asp Ser His Trp Phe Cys Lys Ser Val Asn Asn Leu Ile Met 
            180                 185                 190         


Trp Met Ser Asp Lys Asp Gln Phe Lys Ser Pro His Cys Asp Ile His 
        195                 200                 205             


Thr Trp Asp Cys Ile Val Val Lys Thr Tyr Val Ser Trp Asp Glu Asp 
    210                 215                 220                 


His Asp Thr His Lys Tyr Leu Arg Asn Thr Thr Val Trp Glu Ser Pro 
225                 230                 235                 240 


Asp Ile Gly Arg Val Gly Leu Tyr Asp Ala Cys Lys Lys Glu Phe Cys 
                245                 250                 255     


Gly Val Glu Gly Ile Arg Leu Asn Asn Gly Glu Trp Trp Phe Leu Glu 
            260                 265                 270         


Arg Glu Glu Asn Tyr Tyr Gly Phe Asp Tyr Lys Asp Leu Arg Lys Cys 
        275                 280                 285             


Lys Glu Gly Glu Thr Ile Gly Val Arg Thr His Val Asp Arg Thr Leu 
    290                 295                 300                 


Phe Glu Glu Ile Asp Ile Lys Leu Glu Leu Glu His Ser Lys Cys Ile 
305                 310                 315                 320 


Asp Val Leu Ile Lys Leu Arg Ser Gly Ile Ala Ile Ser Pro Phe Glu 
                325                 330                 335     


Leu Gly Tyr Leu Ala Pro Ser Ser Tyr Gly Lys Gly Tyr Ala Tyr Arg 
            340                 345                 350         


Phe Glu Gln Glu Thr Lys Ile Ile Tyr Gln Cys Tyr Pro Arg Ile Asp 
        355                 360                 365             


Arg Val Pro Gln Ile Lys Ile Val Thr Asp Asn Ala Gln Asn Cys Ser 
    370                 375                 380                 


Asp Gly Lys Met Arg Tyr Met Arg Thr Phe Asn Gln Thr Arg Val Gly 
385                 390                 395                 400 


Lys Tyr Lys Arg Ala Val Cys Met Tyr Lys Asn Val Phe Ile Pro Glu 
                405                 410                 415     


Ala Gln Gln Asp Lys Glu Ala Gly Tyr Asp Ile Gly Lys Trp Gln Phe 
            420                 425                 430         


Ala Gly Ser Asn Asp Ser Ile Glu Gly Asn Ile Ser Lys Asn Gly Trp 
        435                 440                 445             


Ser Asn Phe Arg Ser Gln Ser Gly Ser Glu Tyr Gln Ile Gly Trp Asn 
    450                 455                 460                 


Gly Met Ile Lys Leu Thr Ser Gly Arg Tyr Leu Ile Asn Thr Tyr Ala 
465                 470                 475                 480 


Leu Leu Asp Gly Leu Leu His Glu Ala Gln Leu Ser Ala Leu Glu Val 
                485                 490                 495     


Lys Pro Phe Asp His Pro Val Tyr His His Met Asp Asp Phe Ile Lys 
            500                 505                 510         


Trp Leu Asn Gly Ser Ser Ile Asn Glu Glu Arg Asp Leu Leu Asp Asp 
        515                 520                 525             


Ser Arg Leu Glu Arg Thr Asp Ile Ile Lys Ser Ala Gly Glu Lys Ile 
    530                 535                 540                 


Lys Gly Val Tyr His Asn Ile Val Gly Trp Phe Ser Gly Val Thr Ser 
545                 550                 555                 560 


Val Ile Arg Trp Val Leu Trp Gly Ile Gly Ala Ile Val Thr Leu Tyr 
                565                 570                 575     


Val Ile Ile Lys Ile Arg Arg Val Met Lys Lys Lys Asn Asn Glu Asn 
            580                 585                 590         


Glu Gly Lys Asn Glu Val Lys Gln Phe Phe Glu Lys Leu Ser Lys Ile 
        595                 600                 605             


Lys Thr His Lys Ser Asp Asn Val Leu Pro Thr Asn Lys Ala Gly Ile 
    610                 615                 620                 


Gly Lys Asp Lys Lys Asp Asp Glu Tyr Glu Met Ile Asn Phe Tyr Ser 
625                 630                 635                 640 


<210>  478
<211>  639
<212>  PRT
<213>  Kotonkan ephemerovirus

<400>  478

Met Lys Ser Leu Tyr Tyr Ser Leu Phe Leu Leu Phe Asn Ala Lys Asn 
1               5                   10                  15      


Ile Ile Thr Tyr Arg Ile Ala Asn Leu Pro Phe Asn Cys Glu Asn Glu 
            20                  25                  30          


His Ser Ile Pro Val Glu Ala Ile Asp Cys Pro Val Arg Arg Asn Glu 
        35                  40                  45              


Leu Lys Val Glu Asn Leu Lys Gln Gly Gly Glu His Arg Val Cys Lys 
    50                  55                  60                  


Pro Lys Leu Ser Thr Asp Asp His Val Gln Gly Lys Leu Cys Arg Ile 
65                  70                  75                  80  


Gln Gln Trp Lys Thr Lys Cys Thr Glu Thr Trp Tyr Phe Thr Thr Tyr 
                85                  90                  95      


Ile Glu Tyr Glu Val Val Asp Val Met Pro Asn Lys Ile Glu Cys Ala 
            100                 105                 110         


Lys Glu Trp Glu Arg Thr Lys Ala Gly Phe Pro Ile Ile Pro Phe Phe 
        115                 120                 125             


Pro Pro Ala Val Cys Tyr Trp Asn Ala Glu Asn Val Ile Ser Glu Thr 
    130                 135                 140                 


Phe Val Thr Leu Val Asp His Pro Val Leu Gln Asp Pro Tyr Asn Ser 
145                 150                 155                 160 


Glu Val Ile Asp Pro Ile Phe Tyr Gly Thr Arg Cys Ser Pro Ile Asn 
                165                 170                 175     


Ser Phe Asp Ser His Trp Phe Cys Lys Ser Val Asn Asn Leu Ile Met 
            180                 185                 190         


Trp Met Ser Asp Lys Asp Gln Leu Arg Ser Pro His Cys Asp Ile Lys 
        195                 200                 205             


Thr Trp Asp Cys Ile Val Val Lys Ala Tyr Val Ala Trp Asp Glu Asp 
    210                 215                 220                 


His Asn Thr His Asn Tyr Leu Arg Asn Thr Lys Val Trp Glu Ser Pro 
225                 230                 235                 240 


Asp Ile Gly Arg Val Gly Leu Tyr Asp Ala Cys Lys Lys Arg Phe Cys 
                245                 250                 255     


Gly Val Asp Gly Ile Arg Leu Asn Asn Gly Glu Trp Trp Phe Leu Glu 
            260                 265                 270         


Arg Glu Glu Asn Tyr Tyr Gly Phe Asp Tyr Arg Gly Met Arg Asn Cys 
        275                 280                 285             


Arg Ala Glu Glu Thr Ile Gly Val Arg Thr His Val Asp Arg Thr Leu 
    290                 295                 300                 


Phe Glu Glu Ile Asp Ile Lys Leu Glu Ile Glu His Ser Lys Cys Ile 
305                 310                 315                 320 


Asp Val Leu Ile Lys Leu Arg Ser Gly Ile Thr Ile Ser Pro Phe Glu 
                325                 330                 335     


Leu Gly Tyr Leu Ala Pro Ser Ser Tyr Gly Lys Gly Tyr Ala Tyr Arg 
            340                 345                 350         


Phe Glu Gln Glu Thr Lys Asn Ile Tyr Gln Cys Phe Pro Lys Ile Glu 
        355                 360                 365             


Lys Val Pro Gln Ile Lys Tyr Ile Thr Asp Asp Leu Lys Asn Cys Lys 
    370                 375                 380                 


Asp Asn Lys Thr Arg Tyr Ala Arg Thr Ile Thr Gln Thr Lys Ile Gly 
385                 390                 395                 400 


Asn Tyr Lys Arg Ala Leu Cys Asn Tyr Lys Asn Val Phe Ile Pro Glu 
                405                 410                 415     


Thr Lys Gln Asp Gln Gln Ala Gly Tyr Asp Ile Lys Met Trp Thr Phe 
            420                 425                 430         


Ala Gly Thr Asn Asp Ser Ile Lys Glu His Ile Glu Asn Asn Ser Trp 
        435                 440                 445             


Ser Pro Phe Lys Ser Gln Ser Gly Asn Asn Tyr Thr Ile Gly Trp Asn 
    450                 455                 460                 


Gly Met Ile Lys Leu Asn Thr Gly Arg Tyr Leu Ile Asn Thr Tyr Ala 
465                 470                 475                 480 


Leu Leu Asp Gly Leu Ile His Glu Ala Gln Leu Ser Ala Leu Glu Val 
                485                 490                 495     


Lys Ser Phe Gln His Pro Val Tyr Gln Asn Phe Asp Asp Phe Ala Lys 
            500                 505                 510         


Trp Leu Asn Gly Ser Ser Ile Tyr Glu Glu Arg Glu Leu Leu Asp Asp 
        515                 520                 525             


Ser His Leu Glu Arg Thr Asp Val Ile Lys Ser Ala Gly Glu Lys Ile 
    530                 535                 540                 


Lys Gly Ile Tyr His Asn Ile Val Gly Trp Phe Ser Gly Val Thr Ser 
545                 550                 555                 560 


Ile Val Arg Trp Ile Leu Trp Gly Val Gly Ala Ile Val Thr Val Tyr 
                565                 570                 575     


Val Ile Leu Lys Ile Arg Arg Val Ile Lys Asn Lys His Asp Glu Lys 
            580                 585                 590         


Asp Asn Lys Ser Glu Ile Lys Gln Phe Phe Glu Arg Leu Gly Lys Ile 
        595                 600                 605             


Lys Thr His Lys Gly Asp Asn Asn Ser Val Pro Asn Ile Lys Gly Lys 
    610                 615                 620                 


Arg Asp Lys Lys Glu Asp Glu Tyr Glu Met Ile Asn Phe Tyr Ser 
625                 630                 635                 


<210>  479
<211>  662
<212>  PRT
<213>  Obodhiang ephemerovirus

<400>  479

Met Ala Leu Phe Pro Val Thr Ile Ala Ile Thr Tyr Met Ser Leu Ile 
1               5                   10                  15      


Asn Ser Ala Ile Cys Glu Lys Tyr Val Thr Ile Pro Ile Asn Cys Asn 
            20                  25                  30          


Gly Glu Val Glu Ile Asn Lys Met Asp Val Met Cys Pro Asn Arg Tyr 
        35                  40                  45              


Asn Val Leu Ser Thr Asn His Leu Phe Lys Gly Glu Glu Val Glu Thr 
    50                  55                  60                  


Phe Cys Arg Pro Ser Leu Arg Glu Asn Asp Leu Leu Asp Gly Tyr Leu 
65                  70                  75                  80  


Cys Arg Lys Gln Lys Trp Glu Val Thr Cys Thr Glu Thr Trp Tyr Phe 
                85                  90                  95      


Val Thr Asp Val Gln Tyr Gln Ile Ile Glu Glu Val Pro Thr Val Thr 
            100                 105                 110         


Glu Cys Leu Glu Glu Lys Glu Arg Lys Leu Gln Gly Glu Tyr Ile Pro 
        115                 120                 125             


Pro Tyr Tyr Pro Pro Thr Asn Cys Ile Trp Asn Ala Val Asp Lys Gln 
    130                 135                 140                 


Tyr Arg Thr Phe Ile Ile Leu Ile Glu His Pro Val Ile Glu Asp Pro 
145                 150                 155                 160 


Ile Ser Met Lys Leu Met Asp Ser Lys Phe Asn Lys Pro Cys Asp Pro 
                165                 170                 175     


Val His Gly Lys Val Thr Thr Cys Asp Thr Tyr Asn Pro Leu Val Lys 
            180                 185                 190         


Trp Val Ser Lys Glu Thr Asn Gly Tyr Ser Leu His Cys Gln Ile Lys 
        195                 200                 205             


Ser Trp Glu Cys Ile Pro Val Lys Leu His His Ser Tyr Glu Asp Val 
    210                 215                 220                 


Leu Asp Lys Leu Tyr Leu Glu Ser Pro Asp Phe Gly Val Val Asp Ala 
225                 230                 235                 240 


Ser Lys Ile Cys Asn Met Ser Phe Cys Gly His Glu Gly Ile Leu Leu 
                245                 250                 255     


Glu Asn Gly Glu Trp Trp Ser Ile Tyr Arg Ser Gly Phe Thr Asn Gly 
            260                 265                 270         


Tyr Leu Gln Asn His Lys Ser Ile Asn Asn Arg Ile Glu Ser Cys Ser 
        275                 280                 285             


Asp Arg Lys Pro Gly Tyr Lys Leu Thr Lys Leu Asp Thr Thr Tyr Met 
    290                 295                 300                 


Asp Leu Glu Phe Glu Ile Glu Leu Glu His Glu Lys Cys Leu Gly Thr 
305                 310                 315                 320 


Leu Glu Lys Leu Gln Asn Gly Glu Tyr Val Thr Pro Leu Asp Leu Ser 
                325                 330                 335     


Tyr Leu Ser Pro Ser Asn Pro Gly Thr Asn Tyr Ala Tyr Arg Phe Glu 
            340                 345                 350         


Tyr Lys Asn Lys Thr Val Asp Lys Cys Val Gln Leu Glu Tyr Thr Tyr 
        355                 360                 365             


Glu Ala Gly Asp Cys Lys Ile Met Phe Asp Gly Arg Glu Gly His Gly 
    370                 375                 380                 


Ala Tyr Tyr Asn Trp Thr Thr Ile Lys Leu Asp Lys Ile Lys Arg Ala 
385                 390                 395                 400 


Val Cys Glu Tyr His Thr Phe Ser Phe Asp Leu Lys Asn Lys Lys His 
                405                 410                 415     


Thr Tyr Ser Asp Lys Asp Asp Pro Arg Ile Gln Ile Asn Lys Thr Phe 
            420                 425                 430         


Val Glu Thr Val Leu Lys Ser Thr Pro Leu Ile Gly Arg Asn Glu Glu 
        435                 440                 445             


His Glu Gly Asn Met Ser Trp Asn Gly Ile Ile Ile Glu Gln Ala Lys 
    450                 455                 460                 


Asp Ser Glu Glu Ile Asn Val Ile Val Pro Ser Thr Ser Gln Tyr Asn 
465                 470                 475                 480 


His Ile Val Ile Lys Lys Leu Leu Arg Lys Leu Asp Met Val Asp Tyr 
                485                 490                 495     


Tyr Gly Tyr Lys Phe Asp Ser Leu Ser Gly Ser Val Ser Tyr Asn Glu 
            500                 505                 510         


Ile Lys Pro Ile Leu Arg Ser Glu Asn Val Gln Asn Ala Glu Arg Val 
        515                 520                 525             


Asp Val Ile Lys Tyr Ile Lys Glu Lys Gly Ser Tyr Ile Ile Asn Gly 
    530                 535                 540                 


Phe Thr Gly Trp Phe Ser Ser Leu Gly Lys Met Val Arg Trp Thr Ile 
545                 550                 555                 560 


Trp Gly Ile Gly Leu Ile Phe Ser Leu Phe Thr Leu Tyr Lys Ile Ile 
                565                 570                 575     


Thr Leu Leu Arg Lys His Ser Asn Leu Asn Lys Lys Glu Lys Glu Gly 
            580                 585                 590         


Gln Ala Lys Ser Thr Ile Met Thr Asn Asn Asn Ser Ser Glu Thr Asn 
        595                 600                 605             


Asp Phe Lys Glu Ser Ile Ile Ile Ser Asp His Pro Lys Gly Val Ala 
    610                 615                 620                 


Arg Lys Leu Phe Asp Tyr Phe Ser Lys Lys Ser Gly Lys Arg Gln Asn 
625                 630                 635                 640 


Ile Tyr Arg Gln Ala Thr Ser Asp Ser Thr Gly Gly Thr Tyr Glu Glu 
                645                 650                 655     


Ile His Phe Phe Asn Val 
            660         


<210>  480
<211>  649
<212>  PRT
<213>  Puchong ephemerovirus

<400>  480

Met Ile Ser Lys Ile Gln Ser Cys Ile Ile Phe Gly Leu Cys Ser Arg 
1               5                   10                  15      


Val Phe Ser Ala Asp Ile Gly Ser Lys Val Phe Asn Val Pro Val Asn 
            20                  25                  30          


Cys Val Gly Glu Lys Pro Ile Lys Pro Thr Glu Ile Thr Cys Pro Lys 
        35                  40                  45              


Arg Tyr Asn Glu Leu Ser Leu Glu Ala His His Thr Leu Ile Glu Gly 
    50                  55                  60                  


Asp Glu Lys Val Glu Gln Ile Cys Arg Pro Ala Leu Arg Asp Asp Asp 
65                  70                  75                  80  


His Val Glu Gly Tyr Val Cys Arg Glu Gln His Trp Glu Thr Glu Cys 
                85                  90                  95      


Glu Glu Thr Trp Tyr Phe Ala Thr Val Ile Asn Tyr His Ile Arg Glu 
            100                 105                 110         


Lys Pro Pro Ser Leu Ser Asp Cys Ile Thr Ala Val Lys Gln Tyr Lys 
        115                 120                 125             


Asp Gly Ile Leu Ile Pro Pro Tyr Tyr Pro Pro Ala Gly Cys Phe Trp 
    130                 135                 140                 


Asn Thr Lys Ile Lys Glu Thr Ile Lys Phe Met Val Leu Ile Lys His 
145                 150                 155                 160 


Arg Ser Ile Leu Asn Pro Ile Asp Asn Leu Val His Asp Thr Gln Phe 
                165                 170                 175     


Ile Asn Pro Cys Asp Leu Lys Gly Ala Gln Lys Asp Gly Cys Lys Leu 
            180                 185                 190         


Lys Asp Ile Thr Gly Leu Trp Ile Pro Glu Leu Glu Asn Gly Leu Ser 
        195                 200                 205             


Ser Glu His Cys Ser Lys Lys His Trp Glu Cys Ile Gly Ile Lys Ser 
    210                 215                 220                 


Tyr Lys Ser Glu Val Asp Glu Lys Thr Arg Ile Trp Glu Ala Pro Glu 
225                 230                 235                 240 


Ile Gly Ile Ile Asn Ile Thr Lys Ser Cys Lys Gln Ser Phe Cys Gly 
                245                 250                 255     


Tyr Arg Gly Val Val Phe Asp Asp Gly Glu Trp Trp Gly Tyr Ala Asn 
            260                 265                 270         


Glu Thr Glu Ala Glu Leu Ile Asp Ala His Ile Pro Thr Cys Ser Gly 
        275                 280                 285             


Lys Lys Pro Gly Ile Arg Val His Asn Asp His Thr Asp Tyr Glu Thr 
    290                 295                 300                 


Tyr Asp Ile Arg Ala Glu Met Glu Asn Glu Arg Cys Gln Asn Thr Ile 
305                 310                 315                 320 


Ser Lys Ile Leu Asn Ser Glu Pro Ile Asn Thr Ile Asp Met Ser Tyr 
                325                 330                 335     


Leu Ser Pro Thr Arg Pro Gly Arg Asp Phe Ala Tyr Arg Phe Lys Gln 
            340                 345                 350         


Val Asn Trp Thr Glu Thr Phe Cys Leu Arg Trp Ala Glu Ser Gly Leu 
        355                 360                 365             


Ile Lys Asp Cys Arg Lys His Trp Lys Leu Ser Asp Arg Gly Gly Lys 
    370                 375                 380                 


Val Thr Lys Glu His Val Gly Ile Gly Gly Tyr Thr Arg Ala Leu Cys 
385                 390                 395                 400 


Glu Phe Arg Pro Ile Val Asp Gln Asp Gly Asp Gly Tyr Ile Ser Lys 
                405                 410                 415     


Thr Glu Leu Gly Arg His Asn Met Ser Ala Glu Phe Ser Ser Met Lys 
            420                 425                 430         


Leu Gly Thr Arg Ser Ser Asn Gln Pro Val Asp Ser Leu Asp Val Gly 
        435                 440                 445             


Phe Asn Gly Ile Val Lys Val Thr Asp Asp Arg Thr Arg Glu Glu Lys 
    450                 455                 460                 


Tyr Met Val Arg Thr Thr Ser Val Tyr Asp Gly Leu Glu Gln Arg Asn 
465                 470                 475                 480 


Arg Leu Met Lys Phe Glu Val Leu Glu Phe Glu Asp Val Val Ser Lys 
                485                 490                 495     


Tyr Gln Gly Glu Gly His Tyr Asp Val Lys Gly Lys Ser Ile Asp Leu 
            500                 505                 510         


Thr Pro Asp Glu Gln Lys Ser Ile Asn Arg Thr Asp Phe Val Lys Thr 
        515                 520                 525             


Ile Ala Asn Gly Gly Lys Glu Ile Val Ser Gly Ile Val Gly Trp Phe 
    530                 535                 540                 


Thr Gly Thr Ala Lys Leu Val Arg Trp Thr Ile Trp Ala Val Gly Ala 
545                 550                 555                 560 


Leu Val Thr Thr Tyr Ala Ile Tyr Lys Leu His Lys Leu Val Arg Gly 
                565                 570                 575     


Lys Pro Arg Ser Glu Glu Asp Arg Ser Gln Ala Glu Asp Arg Ala Glu 
            580                 585                 590         


Glu Asn Lys Arg Ser Ser Trp Phe Asn Ser Gly Lys Lys Asn Asp Leu 
        595                 600                 605             


Arg Lys Asn Pro Leu Lys His Asp Asn Pro Leu Tyr Glu Glu Ile Asp 
    610                 615                 620                 


Leu Glu Asp Thr Tyr Ser Met Arg Lys Lys Glu Gly Trp Lys Thr Asp 
625                 630                 635                 640 


Arg Thr Arg Asp Asn Phe Phe Asp Val 
                645                 


<210>  481
<211>  609
<212>  PRT
<213>  Yata ephemerovirus

<400>  481

Met Met Tyr Leu Phe Leu Leu Ile Leu Ser Tyr Thr Thr Leu Ser Asp 
1               5                   10                  15      


Cys Leu Met Lys Ser Arg Leu Val Asn Leu Pro Thr Asn Cys Arg Asp 
            20                  25                  30          


Glu Thr Pro Ile Asp Lys Glu His Val Glu Cys Pro Phe Arg Arg Asn 
        35                  40                  45              


Glu Leu Arg Val Asp His Leu Gln Arg Arg Glu Leu Thr Lys Leu Cys 
    50                  55                  60                  


Arg Pro Lys Gly Gln Glu Asp Asp His Ile Glu Gly Tyr Val Cys Lys 
65                  70                  75                  80  


Val Gln Thr Trp Arg Thr Thr Cys Leu Glu Thr Trp Tyr Phe Thr Thr 
                85                  90                  95      


Tyr Val Lys Tyr Asp Val Val Glu Glu Thr Pro Thr Pro Ser Asp Cys 
            100                 105                 110         


Phe Lys Glu Leu Glu Arg Ile Arg His Gly Val Pro Ala Val Pro Tyr 
        115                 120                 125             


Phe Ala Pro Ser Val Cys Tyr Trp Asn Ala Glu Asn Thr Ile Arg Val 
    130                 135                 140                 


Thr Leu Thr Thr Leu Thr Pro His Asn Val Ile Glu Asp Pro Tyr Asn 
145                 150                 155                 160 


Leu Lys Leu Leu Asp Pro Ser Phe Pro Gly Gly Ile Cys Asn Gly Thr 
                165                 170                 175     


Arg Ser Gly Phe Cys Tyr Met Lys Asn Glu Arg Ser Leu Trp Ile Pro 
            180                 185                 190         


Ser Ser Ser Ser His Ser Lys His Cys Gln Trp Lys Gly Trp Glu Cys 
        195                 200                 205             


Val Thr Ala His Ile Leu Asn Ser Trp Asp Glu Ser Arg Val Asn Gln 
    210                 215                 220                 


Asp Val Leu Val Asp Ser Thr Val Ile Glu Ala Pro Glu Ile Gly Arg 
225                 230                 235                 240 


Ile Gly Ile Tyr Asp Ala Cys Gln Met Thr Phe Cys Asn Val Thr Gly 
                245                 250                 255     


Ile Lys Leu Ala Thr Gly Glu Trp Trp Val Pro His Asp Tyr Asp Asp 
            260                 265                 270         


Lys Phe Arg Lys Ser Phe Asp Arg Leu Arg His Cys Ser Ser Asp Glu 
        275                 280                 285             


Lys Ile Gly Val Arg Asn His Val Asp Lys Thr Leu Phe Glu Glu Leu 
    290                 295                 300                 


Asp Ile Lys Ala Glu Leu Glu His Gln Arg Cys Ile Asp Ala Leu Met 
305                 310                 315                 320 


Lys Leu Arg Asn Gly Glu Ser Leu Asn Ala Leu Glu Met Ser Tyr Phe 
                325                 330                 335     


Ala Pro Thr Thr Pro Gly Leu Gly Tyr Ala Tyr Arg Phe Val Gln Gln 
            340                 345                 350         


Lys Lys Val Tyr Ser Tyr Cys Ile Gly Tyr Ala Asp Ser Tyr Asp Tyr 
        355                 360                 365             


Arg Ile Cys Lys Lys Tyr Tyr Thr Gln Lys Lys Gly Arg Ala Tyr Gly 
    370                 375                 380                 


Gly Tyr Tyr Asn Phe Thr Lys Thr Ile Leu Gly Thr Ile Val Arg Gly 
385                 390                 395                 400 


Leu Cys Asp Tyr Lys Thr Val Gln Ile Pro Met Gln Ile Ala Gly Ile 
                405                 410                 415     


Arg Glu Ser Arg Met Ser Arg Ser Ser Leu Trp Arg Leu Pro Leu Thr 
            420                 425                 430         


Asn Glu Thr Met Glu Ile His Leu Lys Asn Tyr Ser Trp Ser Leu Leu 
        435                 440                 445             


Glu Asn Glu Gln Thr Asn Ser Ile Tyr Asn Leu Ser Trp Asn Gly Phe 
    450                 455                 460                 


Ile Gln Lys Gly Gly Asp Tyr Ile Ile Asn Ala Phe Ser Leu Tyr Asp 
465                 470                 475                 480 


Gly Leu Leu Arg Asp Ile Gln Val Ala Lys Leu Glu Val Met Ser Val 
                485                 490                 495     


Glu His Pro His Val Ile Glu Asp His Glu Leu Val Asp Pro Ile Ile 
            500                 505                 510         


Lys His Ile Ser Asp Asn Ser Lys Leu Asp Arg Thr Asp Val Val Asp 
        515                 520                 525             


Glu Ile Glu Lys Lys Gly Lys Gly Ile Leu Leu Thr Ile Lys Gly Trp 
    530                 535                 540                 


Phe Ser Gly Leu Ser Gln Ile Val Arg Trp Gly Leu Trp Ile Ile Gly 
545                 550                 555                 560 


Gly Leu Ile Thr Val Tyr Ser Met Tyr Lys Ile Asn Lys Leu Ile Lys 
                565                 570                 575     


Glu Lys Gly Lys Lys Arg Ser Glu Asp Asn Phe His Ser Gly Leu Glu 
            580                 585                 590         


Ala Leu Thr Asn Gln Asn Met Ser Gly Pro Tyr Glu Arg Pro Phe Phe 
        595                 600                 605             


Ser 
    


<210>  482
<211>  618
<212>  PRT
<213>  Flanders hapavirus

<400>  482

Met Ser Tyr Leu Ile Val Lys Val Val Ile Leu Phe Leu Val Gly Ile 
1               5                   10                  15      


Asp Lys Gln Val Leu Ser Trp Thr His Asp Ser Gly Arg Ser Phe Val 
            20                  25                  30          


Arg Gln Tyr His Asp Pro Asn Trp Phe Asp Gln Thr Met Val Tyr Pro 
        35                  40                  45              


Ile Glu Cys Asn Ser Thr Trp Gln Glu Val Asn Thr Leu Asn Leu Arg 
    50                  55                  60                  


Cys Pro Lys Ser Leu Lys Ile Asp Pro Lys Asn Lys Leu Asn Phe Asp 
65                  70                  75                  80  


Leu Gly Thr Val Tyr His Pro Leu Pro Ser Ser Arg Tyr Val Val Asn 
                85                  90                  95      


Gly Tyr Ile Cys His Lys Gln Thr Trp Ile Ser Lys Cys Glu Glu Thr 
            100                 105                 110         


Trp Tyr Phe Ser Thr Thr Glu Thr Asn Lys Ile Glu Asn Val Pro Ile 
        115                 120                 125             


Thr Pro Glu Asp Cys Arg Glu Ala Val Thr Ile Tyr Glu Met Gly Glu 
    130                 135                 140                 


Tyr Val Asn Pro Phe Phe Pro Pro Phe Tyr Cys Ser Trp Cys Ser Thr 
145                 150                 155                 160 


Gln Ile Asp Lys Lys Thr Phe Val Ile Val Glu Pro His Ile Val Lys 
                165                 170                 175     


Glu Asp Ile Tyr Asn Lys Thr Phe Ile Asp Pro Leu Phe Leu Asn Gly 
            180                 185                 190         


Tyr Cys Asp Gln Leu Pro Cys Lys Thr Ile His Pro Asp Val Leu Trp 
        195                 200                 205             


Val Pro Gln Glu Leu Gln Lys Arg Lys Asp Leu Cys Asn Lys Gly Thr 
    210                 215                 220                 


Trp Glu Thr Gly Lys Val Phe Gly Val Leu Glu Glu Lys Leu Tyr Gln 
225                 230                 235                 240 


Asn Gly Tyr Leu Lys Asp Asn Arg Phe Gly Ile Asp Glu Gln Trp Ile 
                245                 250                 255     


Arg Ser Ser Ile Tyr Gly Leu Arg Ser Leu Val Gly Ser Cys Tyr Arg 
            260                 265                 270         


Gly Val Cys Arg Gln Phe Gly Ile Arg Phe Lys Thr Gly Glu Trp Trp 
        275                 280                 285             


Gly Leu Glu Gly Lys Asp Val Thr Gly Trp Ile Lys Gln Ile Ile Pro 
    290                 295                 300                 


Arg Cys Gln Glu Asn Gln Tyr Val Ser Phe His His Asp Asn Ser Asp 
305                 310                 315                 320 


Glu Asn Ile Ala Glu Ala Gln Leu Val Ala Arg Glu Leu Val Cys Glu 
                325                 330                 335     


Glu Phe Leu Gly Arg Ala Lys Gly Gly Asp Leu Ile Ser Pro Phe Asp 
            340                 345                 350         


Leu Asn Tyr Leu Leu Pro Leu Asn Pro Gly Leu Gly Pro Ser Tyr Arg 
        355                 360                 365             


Ala Phe Lys Arg Ile Leu Lys Lys Asp Ser His Gly Gly Ser Ser Pro 
    370                 375                 380                 


Gln Phe Arg Leu Glu Lys Arg Asp Cys Ile Tyr Ser Val Val His Asn 
385                 390                 395                 400 


Val Thr Glu Lys Val Asn Ile Thr Asn Asn Lys Leu Ala Ile Gly Gln 
                405                 410                 415     


Leu Phe Asp Gly Ser Tyr Val Tyr Ile Asn Glu Ser Glu Phe Ser Arg 
            420                 425                 430         


Pro Asp Tyr Leu Asn Asn Ser Asp Asn Ala Ser Arg Asp Gly Trp Phe 
        435                 440                 445             


Leu Leu Ser Leu Asn Gly Met Ile Lys Tyr Gly Asn Ser Val Tyr Leu 
    450                 455                 460                 


Pro His Gly Val Ser Thr Gly Leu Ser Gly Ile Gln Asp Ile Val Glu 
465                 470                 475                 480 


Arg Gly Thr Leu Met Leu Leu Asp His Pro Lys Ser Ile Ala Ile Ser 
                485                 490                 495     


Asn Gln Met Asp Leu Ala Lys Asn Ile Tyr Thr Ser Tyr Phe Gln Met 
            500                 505                 510         


Asn Thr Thr Ser Ile Gly Ser Lys Ile Glu Asn Met Ile Ile Arg Ala 
        515                 520                 525             


Lys Asn Ala Val Ser Ser Tyr Phe Ser Gln Leu Thr Asn Ile Ala Trp 
    530                 535                 540                 


Trp Ile Gly Thr Gly Ile Leu Gly Leu Leu Gly Phe Ile Val Ile Lys 
545                 550                 555                 560 


Arg Phe His Leu Ile Gln Leu Ile Cys Gly Lys Lys His Arg Asn Gly 
                565                 570                 575     


Lys Ile Lys Lys Lys Asn Asn Lys Leu Asn Asn Asp Asp Gln Glu Ala 
            580                 585                 590         


His Val Tyr Asp Thr Ile Ser Asn Thr Pro Lys Thr Pro Pro His Gly 
        595                 600                 605             


Lys Gly Thr Gly Val Lys Tyr Phe Asp Tyr 
    610                 615             


<210>  483
<211>  601
<212>  PRT
<213>  Gray Lodge hapavirus

<400>  483

Met Trp Ser Asp Phe Ile Ile Phe Leu Asn Leu Leu Val Glu Ile Ile 
1               5                   10                  15      


Gly Leu Gly Leu Arg Thr Ser His Arg Ala Tyr Val Arg Thr Leu Tyr 
            20                  25                  30          


Asn Asp Ser Asp His Asp Asn Ala Leu Thr Ile Pro Thr Lys Phe Leu 
        35                  40                  45              


Asp Pro Lys Trp Thr Pro Val Thr Ala Leu Asp Ile Ile Cys Pro Thr 
    50                  55                  60                  


Glu Lys Gln Leu Met Pro Glu Phe Arg Ile Ser Thr Glu Leu Gly Thr 
65                  70                  75                  80  


Val Arg His Pro His Thr Gln Val Glu Asp Asn Val Asp Gly Phe Phe 
                85                  90                  95      


Cys His Lys Gln Glu Trp Thr Ser Thr Cys Thr Glu Thr Trp Tyr Phe 
            100                 105                 110         


Ser Ser Thr Glu Glu Thr Lys Ile Ser Asn Leu Glu Ile Ser Glu Gly 
        115                 120                 125             


Glu Cys Glu Glu Ala Ile Thr Leu Tyr Val Ala Gly Glu Lys Ile Glu 
    130                 135                 140                 


Pro Phe Phe Pro Pro Phe Ile Cys Ser Trp Ala Ser Thr Gln Ser Asn 
145                 150                 155                 160 


Ser Lys Ile Phe Val Val Val Thr Pro His Ser Ala Arg Val Asp Ile 
                165                 170                 175     


Tyr Glu Asn Val Tyr Arg Asp Pro Ser Phe Pro Gly Gly Glu Cys Arg 
            180                 185                 190         


Thr Lys Val Cys Lys Thr Val Asn Lys Asp Ile Met Trp Ile Met Arg 
        195                 200                 205             


Gly Asp Glu Lys Arg Ala Asp Thr Cys Asp Val Lys Lys Trp Glu Glu 
    210                 215                 220                 


Gly Pro Leu Tyr Phe Ser Ile Glu Thr Arg Asp Ser Asp Trp Ser Ser 
225                 230                 235                 240 


Ile Ser Thr Phe Ser Ile Asp Glu Ser Trp Val Arg Ser Pro Leu Tyr 
                245                 250                 255     


Gly Ile Arg Lys Leu Lys Gly Ser Cys Arg Thr Pro Ile Cys Gly Ser 
            260                 265                 270         


Pro Gly Ile Arg Phe Ser Ser Gly Glu Trp Trp Gly Leu Lys Phe Ser 
        275                 280                 285             


Glu Asp Met Leu Trp Ile Gln Lys Leu Pro Arg Cys Ala Gly Ser Lys 
    290                 295                 300                 


Val Ser Phe His His Asp Asn His Pro Gly Arg Glu Leu Glu Glu Glu 
305                 310                 315                 320 


Ala Val Val Gln Lys Leu Lys Cys Lys Glu Val Ile Gly Arg Ile Leu 
                325                 330                 335     


Ala Lys Asp Asn Val Thr Pro Val Glu Leu Ala Ser Phe Val Pro Lys 
            340                 345                 350         


Asn Pro Gly Val Gly Leu Ala Tyr Arg Leu Phe Met Thr Arg Lys Asp 
        355                 360                 365             


Glu Arg Ile Gly Leu Arg Glu Tyr Arg Leu Glu Lys Arg Arg Ala Met 
    370                 375                 380                 


Tyr His Leu Val His Asn Ile Thr Arg Lys Leu Glu Ile Gly Asp Ser 
385                 390                 395                 400 


Lys Leu Lys Val Gly His Trp Tyr Asp Gly Val Pro Val Tyr Trp Asn 
                405                 410                 415     


Thr Thr Glu Ile Leu Gly Glu Asn Thr Thr Lys Lys Asp Glu Ile Phe 
            420                 425                 430         


Leu Thr Phe Asn Gly Leu Val Lys Phe His Gly Asp Leu Tyr Leu Pro 
        435                 440                 445             


Glu Ser Ser Ala Ile Gly Gly Ser Lys Leu Val Glu Met Asn Arg Pro 
    450                 455                 460                 


Gly Val Leu Leu Leu Glu Glu Gln Thr Phe Asp Lys Ile Ser Val Lys 
465                 470                 475                 480 


Asn Gln Phe Glu Leu Leu Asp His Val Tyr Lys Phe Glu Phe Lys Lys 
                485                 490                 495     


Asn Asn Thr Asn Leu Ile Gln Lys Ile Ser Ser Ala Leu Glu Ser Ala 
            500                 505                 510         


Gly Gln Phe Ile Gly Thr Tyr Phe Ser Lys Ile Ser Asp Ile Val Trp 
        515                 520                 525             


Trp Ile Gly Gly Gly Ile Ile Gly Leu Leu Ile Thr Gly Ile Cys Ile 
    530                 535                 540                 


Lys Cys Asn Cys Tyr Lys Phe Leu Tyr Lys Arg Lys Glu Lys Asn Thr 
545                 550                 555                 560 


Glu Pro Lys Gly Gln Glu Leu Lys Pro Met Thr Ala Pro Ser Lys Val 
                565                 570                 575     


Ser Asp Asn Val Tyr Ala Thr Ile Asp Pro Pro Ser Val Glu Arg Arg 
            580                 585                 590         


Lys Gly Ser Ser Val Phe Ser His Tyr 
        595                 600     


<210>  484
<211>  619
<212>  PRT
<213>  Hart Park hapavirus

<400>  484

Met Ser Tyr Leu Ile Val Arg Ile Leu Ile Val Phe Leu Ser Tyr Lys 
1               5                   10                  15      


Arg Leu Gln Val Phe Cys Trp Thr His Asp Ser Gly Arg Val Phe Thr 
            20                  25                  30          


Arg Arg Tyr His Asp Pro Asn Trp Phe Asp Gln Thr Met Val Tyr Pro 
        35                  40                  45              


Ile Gly Cys Asn Ser Ser Trp Gln Glu Val Asn Lys Leu Asn Leu Lys 
    50                  55                  60                  


Cys Pro Arg Ser Leu Lys Ile Asp Pro Lys Asn Lys Leu Asn Phe Asp 
65                  70                  75                  80  


Leu Gly Thr Val Tyr His Pro Leu Pro Ser Ser Arg Tyr Val Val Asn 
                85                  90                  95      


Gly Tyr Ile Cys His Lys Gln Asn Trp Ile Ser Lys Cys Glu Glu Thr 
            100                 105                 110         


Trp Tyr Phe Ser Thr Thr Glu Thr Asn Lys Ile Glu Asn Val Pro Ile 
        115                 120                 125             


Thr Glu Glu Asp Cys Arg Glu Ala Val Thr Ile Tyr Glu Met Gly Glu 
    130                 135                 140                 


Tyr Val Asn Pro Phe Phe Pro Pro Phe Tyr Cys Ser Trp Tyr Ser Thr 
145                 150                 155                 160 


Gln Val Asp Gln Lys Thr Phe Val Ile Val Glu Pro His Ile Val Lys 
                165                 170                 175     


Glu Asp Ile Tyr Asn Arg Thr Phe Leu Asp Pro Leu Phe Leu Asn Gly 
            180                 185                 190         


Tyr Cys Asn Gln Val Pro Cys Lys Thr Ile His Pro Asp Val Leu Trp 
        195                 200                 205             


Val Pro Gln Glu Ala Gln Lys Arg Lys Gly Leu Cys Asn Lys Gly Ser 
    210                 215                 220                 


Trp Glu Ser Gly Gln Ala Phe Gly Val Leu Glu Glu Asn Thr Tyr Thr 
225                 230                 235                 240 


Glu Asn Gly Gly Thr Gly Arg Thr Phe Gly Leu Asp Glu Gln Trp Ile 
                245                 250                 255     


Arg Ser Ser Ile Tyr Gly Ile Arg Ser Leu Val Gly Ser Cys Tyr Arg 
            260                 265                 270         


Gly Val Cys His Gln Phe Gly Ile Arg Phe Lys Thr Gly Glu Trp Trp 
        275                 280                 285             


Gly Leu Glu Gly Lys Asp Leu Val Gln Trp Ile Gln Lys Ile Ile Pro 
    290                 295                 300                 


Arg Cys Asp Tyr Lys Gln Tyr Val Ser Phe His His Asp Asn Ser Asp 
305                 310                 315                 320 


Glu Asn Val Ala Glu Ala Gln Leu Val Ala Arg Glu Leu Met Cys Glu 
                325                 330                 335     


Glu Phe Ile Gly Arg Ala Lys Gly Gly Asp Pro Ile Ser Pro Ile Asp 
            340                 345                 350         


Leu Asn Tyr Leu Leu Pro Leu Asn Pro Gly Ile Gly Pro Ala Tyr Arg 
        355                 360                 365             


Ala Phe Lys Arg Ile Leu Lys Arg Asp Ser His Gly Gly Thr Ser Pro 
    370                 375                 380                 


Glu Phe Arg Leu Glu Lys Arg Asp Cys Ile Tyr Ser Thr Leu His Asn 
385                 390                 395                 400 


Val Ser Asp Asn Val Asn Ile Thr Asn Gly Lys Leu Gln Ile Gly Gln 
                405                 410                 415     


Leu Phe Asp Gly Thr Tyr Val Tyr Ile Asn Gln Ser Glu Phe Glu Arg 
            420                 425                 430         


Pro Asp Tyr Leu Asn Lys Ser Asp Asn Val Ser Arg Asp Gly Trp Phe 
        435                 440                 445             


Leu Leu Ser Val Asn Gly Met Ile Lys Tyr Gly Gln Ser Val Tyr Leu 
    450                 455                 460                 


Pro His Gly Val Ser Thr Gly Leu Ser Gly Ile Gln Asp Ile Val Glu 
465                 470                 475                 480 


Arg Gly Thr Leu Met Leu Leu Asp His Pro Lys Ser Ile Ala Ile Ala 
                485                 490                 495     


Asn Gln Met Glu Leu Ala Lys Asn Ile Tyr Thr Ser Tyr Phe Gln Met 
            500                 505                 510         


Asn Thr Thr Ser Ile Gly Thr Gln Ile Glu Asn Met Ile Val Lys Ala 
        515                 520                 525             


Lys Asn Ala Val Ser Ser Tyr Phe Ser Gln Leu Thr Asn Ile Ala Trp 
    530                 535                 540                 


Trp Val Gly Thr Gly Ile Leu Gly Leu Ile Gly Phe Ile Leu Ile Arg 
545                 550                 555                 560 


Arg Phe Asn Val Leu Gln Leu Leu Arg Gly Lys Lys Asn Lys Ser Lys 
                565                 570                 575     


Lys Glu Val Thr Gln Arg Asn Arg Arg Leu Ser Ser Val Gly Ser Gly 
            580                 585                 590         


Ile His Ile Tyr Asp Thr Ile Ser Asn Thr Pro Lys Thr Pro Pro His 
        595                 600                 605             


Gly Lys Gly Asn Gly Val Lys Tyr Phe Glu Tyr 
    610                 615                 


<210>  485
<211>  623
<212>  PRT
<213>  Holmes hapavirus

<400>  485

Met Ser Phe Leu Ile Ala Ile Ile Ile Leu Phe Ile Asn Ile Asp Lys 
1               5                   10                  15      


Leu His Cys Tyr Val Val Gln Ser Asn Phe Gly Gly Ile Arg Glu Ser 
            20                  25                  30          


Lys Val Asn Ile Leu Gly Asn Val Ile Pro Tyr Ser Thr Thr Phe Lys 
        35                  40                  45              


His Glu Val Leu Lys Lys Gln Trp Asp Tyr Arg His Asp Lys Gly His 
    50                  55                  60                  


Arg Thr Val Leu Pro Thr Asn Cys His Ser Ser Trp Asn Thr Val Ser 
65                  70                  75                  80  


Pro Ala Thr Met Lys Cys Pro Arg Arg Lys Ile Ile Gly Lys Asp Gly 
                85                  90                  95      


Leu Tyr Asn Thr Tyr Ile Gly Asp Phe Trp His Pro His Ser Asp Lys 
            100                 105                 110         


Gly Ser Glu Val Lys Gly Phe Ile Cys Gln Lys Thr Arg Trp Ile Ser 
        115                 120                 125             


Thr Cys Ile Glu Thr Trp Tyr Phe Ser Thr Thr Lys Glu Thr Gln Ile 
    130                 135                 140                 


Asp Glu Ile Pro Thr Phe Lys Glu Asp Cys Leu Ala Ala Ile Thr Leu 
145                 150                 155                 160 


Val Asp Ser Gly Glu Tyr Ile Glu Pro Phe Phe Pro Pro His Val Cys 
                165                 170                 175     


Ser Trp Ala Ser Thr Asn Lys Asn Ala Lys Asp Phe Val Thr Val His 
            180                 185                 190         


Glu His Ser Val Val Leu Asp Ile Tyr Glu Asn Ser Leu Leu Asp Pro 
        195                 200                 205             


Ile Phe Leu Ser Gly Lys Cys Lys Asp Arg Val Cys His Thr Ile His 
    210                 215                 220                 


Lys Asp Val Leu Trp Val Glu Ala Thr Asp Asn Glu Arg Asp Asp Phe 
225                 230                 235                 240 


Cys Val Ala Thr Ala Trp Glu Phe Ser His Val Phe Ala Asp Ile Asp 
                245                 250                 255     


Ile Asp His Asp Lys Asn Asn Pro Ile Tyr Ser Ile Gly Glu Thr Ile 
            260                 265                 270         


Asp Ser Glu Ile Tyr Gly Pro Arg Ser Leu Glu Asp Ala Cys Ile Ile 
        275                 280                 285             


Lys Val Cys Gly Ile Pro Gly Ile Arg Phe Ser His Gly Glu Trp Trp 
    290                 295                 300                 


Gly Ile Arg Ser Leu Ser Asn Arg Ile Pro Met Glu Asp Phe Met Tyr 
305                 310                 315                 320 


Lys Cys His Asn Gly Thr Asn Val Gly Phe Val His Asn Ile Trp Thr 
                325                 330                 335     


Pro Ser Glu Leu Ile Gly Glu Ile Thr Tyr Arg Asp His Lys Cys Leu 
            340                 345                 350         


Asp Val Leu Ser Ser Phe Leu Gly Arg Arg Lys Ile Asn Pro Tyr Glu 
        355                 360                 365             


Leu Ser Tyr Leu Val Gln Asp Phe Pro Gly Glu Gly Pro Ala Tyr Arg 
    370                 375                 380                 


Ile Met Lys Gln Tyr Thr Gly Lys Asp Lys Thr Lys Ala Thr Phe Thr 
385                 390                 395                 400 


Leu Gln Thr Lys Thr Cys Arg Tyr His Val Val Tyr Ile Asp Lys Leu 
                405                 410                 415     


Thr Phe Ser Pro Ile Asn Glu Ser Asp Glu Val Tyr Glu Leu Gly Ile 
            420                 425                 430         


Trp Gly Asn Gly Arg Lys Val Ile Leu Asn Ser Thr Glu Val Gly Ile 
        435                 440                 445             


Asn Pro Thr Tyr Val Asn Pro Ser Lys Asp Trp Glu Leu Leu Glu Thr 
    450                 455                 460                 


Phe Asn Gly Leu Met Arg Phe Gly Ser Asp Leu Val Leu Pro Gln Ala 
465                 470                 475                 480 


Val Tyr Thr Asp His Pro Asn Ile Thr Ser Leu Leu Glu Asp Tyr Glu 
                485                 490                 495     


Ile Ser Leu Ile Gly His Pro Lys Glu Ile Leu Ile Gln Asp Gln Asp 
            500                 505                 510         


Glu Leu Ser Glu Val Tyr Lys Phe His Ala Arg Ser Asn Ser Thr Asn 
        515                 520                 525             


Val Val Ser Leu Ala Glu Asn Phe Val Lys Gly Ile Gly Lys Ser Ile 
    530                 535                 540                 


Gly Asn Phe Phe Gly Gly Thr Lys Asn Leu Ile Trp Trp Leu Val Thr 
545                 550                 555                 560 


Ile Ile Leu Ser Thr Leu Gly Thr Tyr Ile Ala Tyr Lys Leu Gly Leu 
                565                 570                 575     


Phe Asn Phe Leu Lys Lys Ile Leu Val Gln Asp Ala Asp Asp Lys Pro 
            580                 585                 590         


Ser Asn Arg Met Ser Asn Ile Tyr Glu Glu Pro Leu Lys Leu Gly Glu 
        595                 600                 605             


Arg Lys Thr His Leu Val Lys Asn Pro Phe Phe Asp Asn Gly Ile 
    610                 615                 620             


<210>  486
<211>  665
<212>  PRT
<213>  Joinjakaka hapavirus

<400>  486

Met Ile Leu Ile Arg Trp Phe Leu Trp Ile Ser Leu Ser Leu Leu Leu 
1               5                   10                  15      


Leu Gly Ile Asn Glu Val Asp Gly Ile Leu Trp Asp Phe Arg Ile Asn 
            20                  25                  30          


Arg Leu Val Arg Asn Lys Arg Lys Thr Gln Lys Thr Lys Leu Asp Gln 
        35                  40                  45              


Ile Gly Asn Gly Val Val Ile Gln Pro Ile Asp Pro Lys Glu Val His 
    50                  55                  60                  


Tyr Asn Ile Val Lys Pro Ser Ile Gln Ile Lys Asn Gln Ser His Pro 
65                  70                  75                  80  


Val Ile Glu Ile Asp Asp Gln Lys Glu Pro Glu Leu Lys Leu Glu Asp 
                85                  90                  95      


Phe Asp Trp Val Ser Gly Asn Glu Phe Glu Gly Val Val Asn Met Pro 
            100                 105                 110         


Val Asn Cys Leu Thr Asn Trp Lys Val Ile Asn Pro Tyr Ala Ile Arg 
        115                 120                 125             


Cys Pro Thr Phe Tyr Glu His Asp Arg Tyr Gly Gly Gly Arg Thr Val 
    130                 135                 140                 


Ile Gly Thr Ala Val His Pro Glu Glu Ile Glu His Asn Ile Ile Pro 
145                 150                 155                 160 


Gly Phe Met Cys Gln Lys Gln Thr Trp Val Thr Glu Cys Thr Glu Ala 
                165                 170                 175     


Trp Tyr Trp Ser Thr Thr Val Lys Asn Tyr Val Glu Ser Ser Pro Val 
            180                 185                 190         


Val Glu Met Glu Cys Leu Met Ala Leu Ala Lys Glu Lys Val Gly Thr 
        195                 200                 205             


Tyr Val Asp Pro Phe Phe Pro Pro Ala Glu Cys Ala Trp Asn Ala Asn 
    210                 215                 220                 


Ser Arg Ser Ser Lys Glu Phe Val Thr Leu His Pro His Asp Val Arg 
225                 230                 235                 240 


Phe Asp Phe Tyr Gln Tyr Ser Lys Val Asp Pro Leu Phe Val Gly Gly 
                245                 250                 255     


Lys Cys Asn Glu Lys Ser Cys Pro Thr Ile His Gln His Val Ile Trp 
            260                 265                 270         


Ile Gly Lys Asn Pro Val Pro Leu Glu Gly Thr Cys Asn Leu Asp Arg 
        275                 280                 285             


Trp Arg Gln Ser Asp Ile Phe Ala Leu Glu Thr His Thr Ser Glu Lys 
    290                 295                 300                 


Lys Val Ser Asp Lys Val Thr Ile Tyr Leu Glu Phe Ile Glu Ser Ala 
305                 310                 315                 320 


Thr Tyr Gly Met Arg Ser Thr Lys Asn Ala Cys Trp Thr Arg Phe Cys 
                325                 330                 335     


Asp Val Pro Gly Ile Arg Phe Asn Asp Gly Glu Trp Trp Gly Ile Lys 
            340                 345                 350         


Ser Gly His Asn Val Ala Leu Asp Phe Leu Pro Glu Cys Gly Lys Lys 
        355                 360                 365             


Ser Leu Ile Thr Leu His His Ala Val Asn Gln Asp Ser Glu Phe Lys 
    370                 375                 380                 


Asn Arg Leu Ser Leu Lys His Tyr Lys Cys Thr Glu Val Leu Thr Lys 
385                 390                 395                 400 


Leu Ile Ser Gly Ser Val Ile Thr Pro Met Asp Ile Ser Tyr Leu Ile 
                405                 410                 415     


Ser Asp Arg Pro Gly Leu Gln Ser Tyr Tyr Arg Phe Ser Ala Lys Gln 
            420                 425                 430         


Lys Gly Asn Gly Pro Val Met Gly Gly Gly Asn Asn Tyr Met Ile Glu 
        435                 440                 445             


Gln Lys Glu Cys Met Tyr Gln Phe Val Leu Leu Glu Ser Asp Arg Phe 
    450                 455                 460                 


Asn Ile Thr Lys Gln Ser Asp Gln Ile Asn Val Gly Met Thr Leu Gln 
465                 470                 475                 480 


Gly Asp His Ile Tyr Ile Asn Leu Thr Asp Phe Gln His Thr Lys Gly 
                485                 490                 495     


Asn Lys Ser Asn Asp Ile Asn Arg Phe Thr Met Thr Val Asn Gly Tyr 
            500                 505                 510         


Leu Lys Thr Gly Asn Val Leu Val Leu Pro Val Asp Glu Ile Thr Ser 
        515                 520                 525             


Glu Ser Val Asp Asn Thr Leu Tyr Thr Pro Ile Gly Tyr His Leu Ile 
    530                 535                 540                 


Glu Glu Glu Glu Ile Gly Asn Tyr Thr Thr Ile Gly Asp Ala Ile Glu 
545                 550                 555                 560 


Lys Ile Leu Ile Leu Asp Pro Arg Leu Asn Arg Thr Asp Ile Val Glu 
                565                 570                 575     


Glu Thr Val His Phe Val Asn Asn Ile Gly Lys Thr Val Ser Ser Phe 
            580                 585                 590         


Phe Gln Gly Thr Ser Ser Leu Leu Trp Trp Gly Val Thr Ser Val Phe 
        595                 600                 605             


Phe Leu Val Ile Val Leu Leu Met Arg Lys Cys Gly Val Ile Asp Trp 
    610                 615                 620                 


Leu Leu Lys Lys Lys Lys Pro Lys Ser Val Glu Arg Met Asn Lys Tyr 
625                 630                 635                 640 


Asn Ser Glu Ser Asn Arg Met Val Asp Asn Lys Thr Ser His Gly Asn 
                645                 650                 655     


Val Asn Gly Gly Phe Phe Gly Asn Val 
            660                 665 


<210>  487
<211>  611
<212>  PRT
<213>  Kamese hapavirus

<400>  487

Met Ser Tyr Leu Leu Val Ile Ile Leu Ile Thr Ile Asn Arg Leu Tyr 
1               5                   10                  15      


Ala Phe Ser Arg Asp Ala Asp His Trp Tyr Val Arg Val Pro His Asp 
            20                  25                  30          


Gln Ser Trp Phe Asp Asn Val Ile Thr Phe Pro Ile Asp Cys Lys Glu 
        35                  40                  45              


Pro Trp Gln Gln Ile Thr Ser Gln Asn Leu Asn Cys Pro Ser Phe Asn 
    50                  55                  60                  


Asn Ile Ser Ala Glu Ala Lys Ala Ser Phe Asn Leu Gly Thr Val Phe 
65                  70                  75                  80  


His Pro Leu Ala Ser Ser Arg Leu Thr Val Asp Gly Tyr Leu Cys His 
                85                  90                  95      


Lys Gln Ser Trp Ile Ser Gln Cys Val Glu Thr Trp Tyr Phe Ser Thr 
            100                 105                 110         


Thr Glu Thr Asn Thr Ile Ser Asn Leu Pro Ile Thr Lys Ser Glu Cys 
        115                 120                 125             


Glu Glu Ala Ile Thr Met Tyr Glu Met Gly Glu Tyr Thr Asn Pro Phe 
    130                 135                 140                 


Phe Pro Pro Phe Tyr Cys Ser Trp Cys Ser Thr Gln Thr Asp Gln Lys 
145                 150                 155                 160 


Thr Phe Val Ile Val Glu Pro His Ser Val Arg Glu Asp Val Tyr Asn 
                165                 170                 175     


Gly Thr Phe Val Asp Pro Leu Phe Val Asp Gly Tyr Cys Ser Ala Asp 
            180                 185                 190         


Tyr Cys Arg Thr Ile His Pro Asp Val Leu Trp Val Pro Arg Gly Gln 
        195                 200                 205             


Ser Met Arg Lys Asp Val Cys Asn Lys Gly Leu Trp Glu Ser Gly Thr 
    210                 215                 220                 


Val Phe Gly Val Leu Glu Glu Arg Asp Glu Asp Leu Tyr Tyr Ser Ile 
225                 230                 235                 240 


Glu Glu Gln Leu Ile Arg Ser Ser Ile Tyr Gly Val Arg Arg Leu Glu 
                245                 250                 255     


Gly Ala Cys Tyr Arg Gly Val Cys Asn Gln Phe Gly Ile Arg Phe Gln 
            260                 265                 270         


Ser Gly Glu Trp Trp Gly Leu Ala Gly Arg Asp Val Val Ile Trp Ile 
        275                 280                 285             


Thr Arg Ile Leu Lys Gln Cys Ala Arg Gly Gln Arg Ile Ser Leu Ser 
    290                 295                 300                 


His Asp Asn His Asp Glu Arg Met Ala Glu Thr Gln Glu Leu Met Arg 
305                 310                 315                 320 


Thr Met Leu Cys Glu Asn Val Lys Ser Arg Ile Leu Ser Asn Asp Pro 
                325                 330                 335     


Val Ser Pro Asn Asp Leu Asn Tyr Leu Leu Pro Thr Asn Pro Gly Val 
            340                 345                 350         


Gly Met Ala Tyr Arg Ile Phe Lys Arg Ile Leu Leu Lys Gly Asn His 
        355                 360                 365             


Gly Gly Pro Thr Ser Glu Leu Tyr Met Glu Gln Arg His Cys Met Tyr 
    370                 375                 380                 


Arg Ile Leu His Asn Val Ser Arg Val Ile Asn Gln Thr Ser Gly Thr 
385                 390                 395                 400 


Trp Ile Ile Gly Gln Met Phe Asn Gly Ala Pro Ile Ser Ile Asn Glu 
                405                 410                 415     


Ser Val Phe Glu Arg Pro Ser Tyr Leu Asn Asn Ser Ala Arg Glu Ser 
            420                 425                 430         


Arg Asp Gly Trp Phe Leu Leu Ser Tyr Asn Gly Leu Ile Lys Tyr Gly 
        435                 440                 445             


Asn Val Leu Tyr Thr Pro Ser Ala Val Glu Ser Ser Val Glu Gly Leu 
    450                 455                 460                 


Gly Phe Phe His Asp Arg Thr Ser Leu Leu Leu Leu Asp Ser Pro Lys 
465                 470                 475                 480 


Ser Val Ala Val Ser Ser Gln Met Glu Leu Val Asn Asn Ile Tyr Thr 
                485                 490                 495     


Ser Ile Phe His Ser Asn Thr Thr Ser Val Phe Ser Lys Val Glu Gly 
            500                 505                 510         


Ala Ile Arg Ala Ala Lys Asn Ala Val Ala Ser Tyr Phe Ser Gln Leu 
        515                 520                 525             


Thr Asn Val Ala Trp Trp Val Gly Thr Gly Cys Ile Gly Ile Val Val 
    530                 535                 540                 


Leu Leu Ile Trp Arg Lys Cys His Cys Tyr Asp Leu Leu Cys Lys Lys 
545                 550                 555                 560 


Thr Ser Arg Ser Ser Asp Glu Ile Ser Ser Lys His Ile Tyr Asp Thr 
                565                 570                 575     


Ile Glu Met Lys Pro Arg Thr Arg Val Gln Asn Lys Ala Ser Thr Pro 
            580                 585                 590         


Lys Leu Pro Pro Lys Arg Ala His Gly Lys Gly Leu Ala His Asn Tyr 
        595                 600                 605             


Phe Gln Tyr 
    610     


<210>  488
<211>  612
<212>  PRT
<213>  La Joya hapavirus

<400>  488

Met Glu Leu Ile Lys Ile His Leu Met Leu Ile Ser Phe Phe Thr Ser 
1               5                   10                  15      


Ser Ala Gly Leu Glu Arg Gly Ser Val Gly Ser Ile Ser Leu Ile Ser 
            20                  25                  30          


Thr Glu Lys Leu Asn Leu Ser Thr Ser His His Asp Lys Gly Ile Phe 
        35                  40                  45              


Gln Asn Arg Glu Lys Pro Leu Gly His Glu Val Val Leu Pro Val His 
    50                  55                  60                  


Cys Thr Gly Glu Trp Val Glu Lys Pro Ala Met Ser Leu Ala Cys Pro 
65                  70                  75                  80  


Lys Arg Lys Ile Asn Gly Pro Asp Gly Tyr Tyr Asp Glu Tyr Phe Ala 
                85                  90                  95      


Lys Met Trp His Pro Pro Thr His Ala Ser Pro Glu Val Lys Gly Tyr 
            100                 105                 110         


Leu Cys Gln Lys Thr Thr Trp Asn Ala Lys Cys Glu Glu Thr Trp Tyr 
        115                 120                 125             


Phe Ser Thr Ser Lys Ser Thr Thr Ile Asp Glu Thr Pro Ile Asn Glu 
    130                 135                 140                 


Asp Asp Cys Arg Ala Ala Leu Ile Leu Tyr Lys Thr Gly Glu Leu Leu 
145                 150                 155                 160 


Glu Pro Phe Phe Pro Pro Phe Ser Cys Tyr Trp Asn Asn Ile Asn Ile 
                165                 170                 175     


Asn Ser Lys Thr Phe Val Thr Ile His Glu His Pro Thr Val Leu Asp 
            180                 185                 190         


Leu Tyr Lys Asp Thr Lys Lys Asp Pro Ile Phe Leu His Gly Glu Cys 
        195                 200                 205             


Asp Gly Glu Val Cys Glu Thr Val His Ser Asn Val Leu Trp Val Glu 
    210                 215                 220                 


Ala Pro Leu Glu Glu Arg Asp Asp Phe Cys Asp Pro Ala Leu Trp Glu 
225                 230                 235                 240 


Ser Ser Asn Val Tyr Thr Glu Lys Gly Gly Pro Gln Ile Pro Ile Val 
                245                 250                 255     


Leu Glu Ser Asp Val Tyr Gly Pro Arg Tyr Thr Gln Gly Met Cys Trp 
            260                 265                 270         


Met Arg Ile Cys Gly Val Trp Gly Phe Arg Phe Ser Ser Gly Glu Trp 
        275                 280                 285             


Trp Gly Phe Arg Met Val Asn Lys Asp Phe Gln Gly Leu Trp Tyr Thr 
    290                 295                 300                 


Gly Lys Ile Pro Ser Cys Tyr Gly Asp Phe Glu Val Ser Phe Ala His 
305                 310                 315                 320 


Glu Ala Ile Ala Met Thr Gln Leu Leu Glu Asn Leu Ser Tyr Lys Asp 
                325                 330                 335     


His Lys Cys Val Asp Val Leu Ser Thr Leu Arg Gly Asn Lys Val Ile 
            340                 345                 350         


Asn Ala Tyr Glu Leu Ser Tyr Leu Val Pro Glu His Pro Gly Phe Gly 
        355                 360                 365             


Pro Ala Tyr Arg Ile Leu Met Val Lys Asn Lys Arg Asn Val Thr Gln 
    370                 375                 380                 


Pro Val Phe Ile Leu Gln Thr Lys Asn Cys Arg Tyr Gln Arg Ala Tyr 
385                 390                 395                 400 


Leu Thr Asn Leu Ser Phe Thr Ile Thr Gly Glu Glu Thr Ser Glu Ser 
                405                 410                 415     


Val Lys Val Gly Val Trp Gly Asp Asn Gln Pro Val Tyr Leu Asn Trp 
            420                 425                 430         


Thr Glu Ile Gly Val Asn Ser Thr Tyr Lys Pro Asn Ile Thr Gly Asn 
        435                 440                 445             


Trp His Gln Leu Met Thr Phe Asn Gly Leu Met Arg Phe Asp Lys Thr 
    450                 455                 460                 


Leu Leu Phe Pro Gln Ser Val Phe Val Asp Ala Pro Asn Val Ser Leu 
465                 470                 475                 480 


Leu Leu Asp Gly Phe Gln Leu Asp Leu Ile Glu His Pro His Gln Tyr 
                485                 490                 495     


Phe Gly Arg Asp Glu Lys Thr Pro Ser Ser Leu Tyr Lys Phe Tyr Pro 
            500                 505                 510         


His Gly Asn Ser Thr Asn Val Gly Glu Val Ile Glu Gly Trp Phe Lys 
        515                 520                 525             


Ser Ala Lys Asn Ala Ile Gly Ser Leu Phe Ser Gly Met Ser Ser Leu 
    530                 535                 540                 


Met Trp Trp Ile Ile Ser Thr Val Leu Ser Leu Ile Thr Leu Leu Val 
545                 550                 555                 560 


Cys Tyr Arg Cys Gly Leu Leu Ser Leu Val Lys Arg Met Phe Thr Lys 
                565                 570                 575     


Arg Thr Arg Pro Ser Lys Lys Gly Arg Thr Ser Arg Ser Ser His Arg 
            580                 585                 590         


Met Glu His Ile Tyr Thr Glu Pro Asn Asn Pro Ser Ser Ser Ser Asn 
        595                 600                 605             


Pro Phe Phe Ala 
    610         


<210>  489
<211>  620
<212>  PRT
<213>  Landjia hapavirus

<400>  489

Met Asp Lys Ile Ile Ile Phe Leu Val Met Leu Val Lys Met Thr His 
1               5                   10                  15      


Gly Asn Ile Gln Pro Ile Ile Ile Ser Ser Leu Pro Val Val Ser Gly 
            20                  25                  30          


Ile Leu Arg Phe Ser Thr Arg Ser Asp Ile Val Arg Gln Ser Val Asp 
        35                  40                  45              


Asp Gly Phe Met Asp Asn Thr Ile Ile Phe Pro Thr Gln Cys Gly Gln 
    50                  55                  60                  


Trp Gly Pro Val Arg Pro Glu Asp Leu Arg Cys Pro Thr Pro Gln Gln 
65                  70                  75                  80  


Ser Ser Pro Glu Asp Arg Leu Val Phe Glu Met Gly Ala Val Tyr His 
                85                  90                  95      


Pro Asn Pro Ser Asn Asn Tyr Ile Val Asn Gly His Leu Cys Leu Lys 
            100                 105                 110         


Gln Arg Trp Ser Ser Ile Cys Gln Glu Thr Trp Tyr Phe Ser Thr Thr 
        115                 120                 125             


Glu Ser Asn Lys Ile Asp Asp Leu Pro Ile Thr Asp Ala Glu Cys Gln 
    130                 135                 140                 


Ala Ala Ile Val Ala Phe Lys Ser Gly Glu Asn Leu Ser Pro Phe Phe 
145                 150                 155                 160 


Pro Pro Phe Tyr Cys Ser Trp Ala Ser Thr Gln Thr Asn Ser Lys Asp 
                165                 170                 175     


Phe Ile Ile Ile Glu Gln His Asn Val Gln Glu Ser Ile Tyr Asn Met 
            180                 185                 190         


Thr Phe Leu Asp Pro Leu Phe Leu Asn Gly Val Cys Asn Gln Pro Ile 
        195                 200                 205             


Cys Lys Thr Ile His Pro Glu Leu Ile Trp Val Met Glu Asn Glu Lys 
    210                 215                 220                 


Asn Arg Trp Asp Leu Cys Asn Ile Arg Asn Trp Glu Ala Gly Thr Leu 
225                 230                 235                 240 


His Ser Ala Ile Glu Thr Lys Asp Asp Ser Met Ser Gly Pro Tyr Ser 
                245                 250                 255     


Ile Asp Lys His Trp Ile Arg Ser Ser Ile Tyr Gly Ile Arg Arg Leu 
            260                 265                 270         


Gln Gly Ser Cys Leu Met Gly Val Cys Asn Lys Tyr Gly Ile Arg Phe 
        275                 280                 285             


Ala Ser Gly Glu Trp Trp Gly Leu Asp Asn Lys Glu Ile Leu Lys Trp 
    290                 295                 300                 


Ala Tyr Arg Asn Phe Lys Val Cys Gly Lys Gly Thr Arg Val Ser Phe 
305                 310                 315                 320 


His His Asp Asn His Asp Glu Arg Val Leu Glu Asp Gln Tyr Val Ala 
                325                 330                 335     


Arg Ser Val Met Cys Ser Glu Ile Ile Gly Arg Ile Leu Val Asn Glu 
            340                 345                 350         


His Val Ser Pro Met Asp Leu Ser Leu Leu Ile Pro Ser Asn Pro Gly 
        355                 360                 365             


Lys Gly Arg Ala Tyr Lys Ile Tyr Lys Arg Val Leu Asn Lys Gly His 
    370                 375                 380                 


His Gly Gly Ile Glu Ile Glu Tyr Arg Met Glu Lys Ala Asp Cys Thr 
385                 390                 395                 400 


Tyr His Ile Leu His Asn Thr Thr Arg Ser Leu Thr Ile Glu Gly Gln 
                405                 410                 415     


Glu Ile Thr Ile Gly Glu Trp Phe Asn Gly Glu Leu Met Lys Leu Asn 
            420                 425                 430         


Val Ser Thr Asn Phe Ser Val Pro Gln Tyr Ile Lys Asn Asp Thr Thr 
        435                 440                 445             


Asn Gln Ser Arg Asp Gly Trp Phe Phe Tyr Ser Leu Asn Gly Tyr Thr 
    450                 455                 460                 


Lys Phe Ser Asp Lys Val Tyr Ser Pro Asp Tyr Met Leu Ser Gly Pro 
465                 470                 475                 480 


Val Gly Val Phe Asn Tyr Ser Gln Lys Gly Gln Leu Phe Leu Asp Thr 
                485                 490                 495     


Asp Pro Gln Ile Leu Arg Ala Lys Asp Gln Met Asp Leu Tyr Lys Lys 
            500                 505                 510         


Val Tyr Leu Ser Glu Tyr His Thr Asn Ser Thr Ser Ile Gly Glu Gln 
        515                 520                 525             


Ile Thr His Ile Ile Ser Arg Ala Lys Asn Ala Ile Thr Ser Tyr Phe 
    530                 535                 540                 


Ser Gln Phe Thr Ser Val Met Trp Trp Ile Val Thr Gly Val Leu Ser 
545                 550                 555                 560 


Leu Ile Ala Ile Ile Leu Ile Lys Arg Phe Gly Val Val Ser Lys Ile 
                565                 570                 575     


Lys Lys Ile Ala Phe Lys Asn Asn Asn Lys Ser Asn Asn Lys Lys Ser 
            580                 585                 590         


Ser Gln Thr Lys Thr Val His Ile Tyr Glu Thr Ile Thr Pro Lys Val 
        595                 600                 605             


Ala His Gly Lys Glu Gly Asn Tyr Ala Asp Phe Met 
    610                 615                 620 


<210>  490
<211>  633
<212>  PRT
<213>  Manitoba hapavirus

<400>  490

Met Val Thr Lys Lys Ile Met Met Ile Thr Met Leu Phe Lys Ser Asn 
1               5                   10                  15      


Val Phe Cys Leu Ile Leu Pro Leu Leu Pro Val Ala Asn Ser Leu Leu 
            20                  25                  30          


Arg Thr Gln Asn Trp Gln Phe Val Pro Leu Lys Thr Asp Pro Lys Tyr 
        35                  40                  45              


Ile Asp Asn Thr Ile Val Phe Pro Thr Lys Cys Gly Asp Trp Lys Gln 
    50                  55                  60                  


Ser Asn Lys Leu Asp Leu Thr Cys Pro Thr Ser Glu Gln Ala Ala Pro 
65                  70                  75                  80  


Glu Asn Arg Leu Ile Thr Glu Ile Gly Asn Val Tyr His Pro Ser Pro 
                85                  90                  95      


Ser Asn Gly Phe Val Val Thr Gly His Leu Cys Leu Lys Gln Lys Trp 
            100                 105                 110         


Ile Ser Lys Cys Glu Glu Thr Trp Tyr Phe Ser Ser Thr Glu Thr Asn 
        115                 120                 125             


His Ile Glu Asp Leu Ala Ile Thr Glu Ser Glu Cys Lys Glu Ala Val 
    130                 135                 140                 


Thr Ala His Lys Ala Gly Glu Asn Leu Ser Pro Phe Phe Pro Pro Phe 
145                 150                 155                 160 


Tyr Cys Ser Trp Ala Ser Thr Gln Ile Asn Ser Lys Ile Phe Ile Leu 
                165                 170                 175     


Val Asp Glu His Lys Val Leu Glu Asn Ile Tyr Asn Arg Ser Leu Val 
            180                 185                 190         


Asp Pro Leu Phe Val Gly Gly Asn Cys Gln Gly Asp Val Cys Lys Thr 
        195                 200                 205             


Ile His Pro Glu Thr Met Trp Ile Val Glu Asn Asp Gln Val Arg Ser 
    210                 215                 220                 


Asp Ile Cys Asn Glu Lys Asn Trp Glu Leu Gly Thr Leu His Ser Ala 
225                 230                 235                 240 


Ile Asp Thr Asp Asp Asp Tyr Asn Lys Gly Gln Tyr Ser Ile Asp Leu 
                245                 250                 255     


His Trp Ile Arg Ser Ser Leu Tyr Gly Ile Arg Lys Leu Asp Gly Ser 
            260                 265                 270         


Cys Arg Arg Arg Val Cys Gly Val Pro Gly Ile Arg Phe Ser Asn Gly 
        275                 280                 285             


Glu Trp Trp Gly Ile Lys Asp Pro Lys Ala Leu Ile Leu Ser His Asn 
    290                 295                 300                 


Leu Leu Ser Glu Cys Pro Val Gly Thr Lys Val Ser Phe His His Asp 
305                 310                 315                 320 


Asn His Asp Glu Asn Val Leu Glu Glu Gln Tyr Val Thr Arg Arg Met 
                325                 330                 335     


Met Cys Ala Glu Ile Val Gly Lys Ile Met Val Gly Glu Thr Val Ser 
            340                 345                 350         


Pro Met Asp Leu Ser Leu Leu Ile Pro Thr Asn Pro Gly Arg Gly Lys 
        355                 360                 365             


Ala Tyr Lys Leu Tyr Lys Arg Ala Ile Tyr Lys Asn Thr His Gly Ile 
    370                 375                 380                 


Leu Asp Val Glu Tyr Ala Leu Phe Gln Ser Thr Cys Tyr Tyr His Leu 
385                 390                 395                 400 


Leu His Asn Ser Ser Lys Ile Tyr Asn Ile Thr Glu Asn Glu Glu Leu 
                405                 410                 415     


Thr Ile Gly Tyr Trp Phe Asp Arg Lys Glu Tyr Lys Met Asn Ile Ser 
            420                 425                 430         


Gln Asn Phe Ser Val Pro Asp Val Leu Lys Lys Asn His Asn Val Ser 
        435                 440                 445             


Arg Asp Gly Trp Tyr Phe Tyr Ser Phe Asn Gly Tyr Thr Lys Tyr Ser 
    450                 455                 460                 


Gly Lys Leu Phe Ser Pro Ser Ser Val Leu Glu Gly Phe Val Gly Met 
465                 470                 475                 480 


Leu Asp Tyr Thr Gln Arg Gly Lys Leu Ala Val Ala Asp Ile Pro Pro 
                485                 490                 495     


Gln Asn Val Ile Lys Asn Thr Val Asp Leu Phe Lys Asn Val Tyr Thr 
            500                 505                 510         


Ser Asp Tyr Arg Val Asn Ser Thr Ser Ile Gly Glu Gln Ile Ser Ile 
        515                 520                 525             


Phe Val Lys Asn Ala Lys Asn Ser Val Val His Tyr Phe Ser Gln Leu 
    530                 535                 540                 


Thr Asn Val Met Trp Trp Ile Gly Thr Gly Leu Ile Ser Phe Leu Ile 
545                 550                 555                 560 


Ile Met Leu Phe Arg Arg Phe Gly Leu Phe Gly Lys Val Thr Asn Leu 
                565                 570                 575     


Met Arg Lys Lys Gly Arg Lys Asn Ala Glu His Ala Pro Arg Glu Leu 
            580                 585                 590         


Lys Lys Ile Asn Thr Gln Ser His Lys Arg Ser Asn Ser Ala Ser Thr 
        595                 600                 605             


Ser Gln Asn Val Tyr Glu Thr Ile Lys Asp Arg Gln Thr Ala His Gly 
    610                 615                 620                 


Lys Glu Ser Gly Phe Phe Asp Phe Val 
625                 630             


<210>  491
<211>  575
<212>  PRT
<213>  Marco hapavirus

<400>  491

Met Leu Lys Leu Lys Gln Leu Leu Thr Leu Val Ile Met Ile Cys Gly 
1               5                   10                  15      


Phe Gly Ile Ser Arg Leu Leu Asn Asn Leu Ile His Arg Ser Pro Asn 
            20                  25                  30          


Val Ser Tyr Ser His Pro Pro Lys Lys Leu Ser Ala Met Ser Leu Leu 
        35                  40                  45              


Leu Val Phe Ile Ile Leu Asn Leu Asn Leu Asn Ser Val Ser Pro Ala 
    50                  55                  60                  


Ser His Glu Val Leu Phe Pro Thr Met Cys Glu Ser Gln Trp Lys Asp 
65                  70                  75                  80  


Leu Ser Ile Arg Asp Ile Asn Cys Glu Glu Ser Ser Ile Leu Glu Ser 
                85                  90                  95      


Ser Asp Phe Ala Tyr Ala Asn Pro Ile Val Ser Lys Ile Pro Arg Ser 
            100                 105                 110         


Pro Asn Phe Pro Lys Ala Asn Gly Tyr Leu Cys Ser Gly Gln Ile Trp 
        115                 120                 125             


Ser Ile Lys Cys Glu Glu Thr Trp Tyr Trp Ser Thr Ser Ile Val Arg 
    130                 135                 140                 


Thr Ile Asp Thr Gln Ile Ile Ser Ser Val Glu Cys Leu Ala Ala Ile 
145                 150                 155                 160 


Lys Ser Tyr Lys Glu Gly Thr Leu Ile Glu Pro Phe Phe Asp Glu Pro 
                165                 170                 175     


Asn Cys Ala Trp Asn Ser Ile Asn Ala Leu Glu Arg Lys His Ile Ile 
            180                 185                 190         


Val His Glu His Pro Val Asn Ile Asp Pro Tyr Glu Asp Leu Tyr Leu 
        195                 200                 205             


Asp Pro Leu Phe Leu Gly Ile Gly Cys Gln Lys Ser Pro Cys Asp Thr 
    210                 215                 220                 


Ile His Lys Asp Leu Ile Trp Ile Thr Asp Glu Pro Asn Asn Leu Pro 
225                 230                 235                 240 


Cys Thr Thr Asp Met Trp Met Thr Asp Ile Tyr Lys Val Ser Gln Asp 
                245                 250                 255     


Lys Leu Leu Val Lys Ser Glu Ala Met Gly Ile Arg Ser Leu Lys Gly 
            260                 265                 270         


Ser Cys Ile Met Lys Leu Cys Asn His Pro Gly Ile Arg Phe Ser Ser 
        275                 280                 285             


Gly Glu Trp Trp Gly Thr Tyr Tyr Asn His Pro Gln Gln Ala Asp Lys 
    290                 295                 300                 


Ile Pro Asn Cys Asn Pro Asn Glu Lys Ile Ser Leu Ser His Arg Ser 
305                 310                 315                 320 


Thr Ile Thr Glu Lys Leu Ile Val Glu Ser Asp Leu Ser Glu Tyr Ser 
                325                 330                 335     


Cys Tyr Gln Ser Leu Ser Lys Ile Tyr Asn Lys Glu Leu Ile Ser Leu 
            340                 345                 350         


Leu Asp Phe Tyr Tyr Ile Val Asn Lys Ser Ser Gly Glu Lys Met Ala 
        355                 360                 365             


Lys Arg Leu Ile Gln His Lys His Asp Arg Arg Tyr Lys Ile Gln Gly 
    370                 375                 380                 


Arg Leu Cys His Tyr Arg Phe Ile Thr Pro Gln Ser Asn Pro Asn Ile 
385                 390                 395                 400 


Gln Lys Asn Pro Asn Gly Leu Leu Gln Ile Gly Ile Asp His Asn Ser 
                405                 410                 415     


Phe Pro Val Lys Ile Asn Val Ser Ser Tyr Phe Asp Val Asn Asp Pro 
            420                 425                 430         


Thr Leu Asn Trp Thr Val Val Ser Met Asp Gly Ile Thr Tyr Ser Pro 
        435                 440                 445             


Ala Gly Leu Lys Phe Pro Tyr His Glu Asn Ile Leu Asp Leu Leu Glu 
    450                 455                 460                 


Thr Ile Leu Asp Lys Pro Asp Asn Leu Ala Leu Leu Asn Arg Pro Glu 
465                 470                 475                 480 


Lys Thr Ile Pro Arg Leu Glu Gly Gly Thr Asn Asn Leu Leu Lys Ser 
                485                 490                 495     


Ser Thr His Ser Asn Ser Thr Asn Leu Met Thr Ser Thr Leu Asn Glu 
            500                 505                 510         


Leu Ser Ser Leu Gly Ser Leu Ile Ser Gly Trp Phe Asp Met Thr Trp 
        515                 520                 525             


Val Arg Thr Leu Ile Gly Leu Val Ile Ala Phe Ile Ile Ile Ile Ile 
    530                 535                 540                 


Cys Phe Arg Val Phe Lys Cys Phe Ile Pro Asn Phe Gly His Lys Thr 
545                 550                 555                 560 


His Thr Ala Ile Ser Glu His Ala Ser Arg Asp Asn Leu Phe Pro 
                565                 570                 575 


<210>  492
<211>  602
<212>  PRT
<213>  Mosqueiro hapavirus

<400>  492

Met Phe Pro Leu Ser Thr Val Leu Leu Pro Met Leu Phe Ser His Val 
1               5                   10                  15      


Gln Ser Trp Thr His Asp Val Gly Arg Asp Tyr Ile His Arg Pro His 
            20                  25                  30          


Asn Pro Asp Trp Phe Asp Asn Val Ile Ser Phe Pro Thr Glu Cys Tyr 
        35                  40                  45              


Thr Asp Trp Thr Leu Val Arg Ala His Glu Ile Lys Cys Pro Ser Leu 
    50                  55                  60                  


Ser Ser Ile Asn Leu Asp Asp Lys Leu Ser Phe Lys Leu Gly Thr Val 
65                  70                  75                  80  


Met His Pro Leu Pro Asn Asn Lys Tyr Thr Val Asp Gly Tyr Ile Cys 
                85                  90                  95      


His Lys Gln Gln Trp Ile Ser Lys Cys Glu Glu Thr Trp Tyr Phe Ser 
            100                 105                 110         


Thr Thr Glu Thr Asn Ser Ile Glu Asn Leu Pro Ile Gly Ala Thr Glu 
        115                 120                 125             


Cys Met Glu Ala Ile Thr Val Tyr Glu Ser Gly Glu Tyr Asn Asn Pro 
    130                 135                 140                 


Phe Phe Pro Pro Phe Tyr Cys Ser Trp Cys Ser Thr Gln Ile Asp Gln 
145                 150                 155                 160 


Lys Thr Phe Ile Val Ile Glu Glu His Thr Ala Gln Glu Asn Ile Tyr 
                165                 170                 175     


Asn Ala Ser Tyr Ile Asp Pro Met Phe Val Gly Gly Lys Cys Ser Ser 
            180                 185                 190         


Asn Leu Cys Lys Thr Ile His Pro Asp Val Leu Trp Val Ala Lys Arg 
        195                 200                 205             


Glu Glu Ile Arg Arg Asp Ala Cys Asn Arg Lys Thr Trp Glu Thr Gly 
    210                 215                 220                 


Asp Val Tyr Gly Leu Val Glu Glu Lys Lys Phe Asp Asn Asp Gln Arg 
225                 230                 235                 240 


Asp Phe Gly Ile Gly Glu Gln Trp Ile Arg Ser Ser Ile Tyr Gly Val 
                245                 250                 255     


Arg Arg Leu Asp Gly Ser Cys Tyr Ser Lys Ile Cys Gly Gln Phe Gly 
            260                 265                 270         


Ile Arg Phe Asn Thr Gly Glu Trp Trp Gly Leu Asp Gly Gln Gly Val 
        275                 280                 285             


Lys Ile Trp Leu Arg Lys Ile Leu Lys Pro Cys Gln Gly Gly Leu Arg 
    290                 295                 300                 


Ile Ser Phe His His Asp Asn His Asp Glu Thr Met Ala Ile Ala His 
305                 310                 315                 320 


Ser Val Ala Arg Glu Val Thr Cys Glu Glu Val Thr Gly Arg Ile Leu 
                325                 330                 335     


Asn Gln Gly Phe Ile Ser Ala Phe Asp Leu Ala Tyr Leu Asn Pro Leu 
            340                 345                 350         


Asn Pro Gly Arg Gly Asn Val Tyr Arg Val Phe Lys Arg Val Ile Lys 
        355                 360                 365             


Gly Arg His Ala Asp Glu Gln Tyr Glu Tyr Lys Met Glu Lys Lys Tyr 
    370                 375                 380                 


Cys Met Tyr Arg Thr Leu His Asn Val Ser Asp Val Ile Asn Gln Thr 
385                 390                 395                 400 


Arg Gly Lys Phe Leu Leu Gly Tyr Phe Phe Asp Gly Ser Pro Phe Tyr 
                405                 410                 415     


Leu Asn Gln Ser Asp Phe Glu Gly Ala Gly Lys Tyr Gly Asn Glu Arg 
            420                 425                 430         


Asn Thr Ser Arg Asp Gly Trp Phe Leu Leu Thr Tyr Ala Gly Leu Thr 
        435                 440                 445             


Lys Phe Gln Gln Thr Leu Tyr Thr Asn Glu Gly Val Ser Asn Ser Gln 
    450                 455                 460                 


Ala Ala Leu Arg Asn Leu His Asp Pro Gly Arg Leu Ala Leu Ala Glu 
465                 470                 475                 480 


Glu Thr Glu Ile Pro Asn Val Arg Asp Gln Met Asp Leu Ala Asn Lys 
                485                 490                 495     


Val Tyr Asn Ser Trp Phe Lys Met Asn Thr Thr Ser Val Gly Glu Arg 
            500                 505                 510         


Ile Thr Thr Phe Ile Asn Asn Ala Lys Ser Ala Val Ser Asn Tyr Phe 
        515                 520                 525             


Ser Gln Leu Thr Asn Val Ile Trp Trp Val Gly Thr Gly Ala Ile Gly 
    530                 535                 540                 


Leu Ile Val Val Ile Leu Gly Arg Arg Phe Tyr Arg Tyr Arg Lys Ser 
545                 550                 555                 560 


Ser Lys Pro Pro Ala Leu Pro Lys Arg Leu Asp Ser Val Glu Thr Gln 
                565                 570                 575     


Ser Thr His Ile Tyr Glu Pro Val Arg Ser Pro Gln Pro Val Ala Arg 
            580                 585                 590         


Gly Asn Gln Gly His Pro Phe Phe Ser Phe 
        595                 600         


<210>  493
<211>  611
<212>  PRT
<213>  Mossuril hapavirus

<400>  493

Met Ser Tyr Leu Leu Val Ile Ile Leu Ile Gln Val Pro Arg Leu Phe 
1               5                   10                  15      


Ala Ile Phe Arg Asp Thr Asp Gln Trp Tyr Val Arg Leu Pro His Asp 
            20                  25                  30          


Lys Thr Trp Phe Asp Asn Ile Leu Thr Phe Pro Ile His Cys Lys Glu 
        35                  40                  45              


Pro Trp Gln Pro Ile Thr Ser Gln Asn Leu Asn Cys Pro Ser Phe Asn 
    50                  55                  60                  


Asn Ile Ser Val Glu Ala Lys Ala Ser Phe Lys Ile Gly Thr Val His 
65                  70                  75                  80  


His Pro Leu Thr Ser Ser Arg Leu Thr Val Asp Gly Tyr Leu Cys His 
                85                  90                  95      


Lys Gln Ser Trp Val Ser Gln Cys Val Glu Thr Trp Tyr Phe Ser Thr 
            100                 105                 110         


Thr Glu Thr Asn Thr Ile Ser Asn Leu Pro Ile Thr Arg Asp Glu Cys 
        115                 120                 125             


Glu Glu Ala Ile Thr Thr Tyr Glu Met Gly Glu Tyr Thr Asn Pro Phe 
    130                 135                 140                 


Phe Pro Pro Phe Tyr Cys Ser Trp Cys Ser Thr Gln Thr Asp Gln Lys 
145                 150                 155                 160 


Thr Phe Val Ile Val Glu Pro His Ser Val Arg Glu Asp Val Tyr Asn 
                165                 170                 175     


Gly Thr Phe Val Asp Pro Leu Phe Ile Gly Gly Ser Cys Arg Leu Asp 
            180                 185                 190         


Tyr Cys Asn Thr Ile His Pro Asn Val Leu Trp Val Pro Arg Gly Ile 
        195                 200                 205             


Ser Met Arg Lys Asp Val Cys Asn Gln Lys Leu Trp Glu Ser Gly Thr 
    210                 215                 220                 


Val Phe Gly Val Leu Glu Glu Lys Glu Gly Asp Met His Tyr Gly Ile 
225                 230                 235                 240 


Glu Glu Gln Met Ile Arg Ser Ser Ile Tyr Gly Val Arg Arg Leu Glu 
                245                 250                 255     


Gly Ala Cys Tyr Arg Gly Val Cys Gly Arg Phe Gly Ile Arg Phe Pro 
            260                 265                 270         


Ser Gly Glu Trp Trp Gly Leu Ser Gly Asn Glu Val Val Arg Trp Val 
        275                 280                 285             


Leu Arg Ile Leu Lys Arg Cys Glu Lys Gly Glu Arg Val Ser Leu Ser 
    290                 295                 300                 


His Asp Asn His Asp Glu Arg Met Ala Glu Thr Gln Glu Leu Met Arg 
305                 310                 315                 320 


Thr Met Met Cys Glu Asn Val Arg Ser Arg Ile Leu Ser Asn Asp Pro 
                325                 330                 335     


Ile Ser Pro Asn Asp Leu Asn Tyr Leu Leu Pro Val Asn Pro Gly Ile 
            340                 345                 350         


Gly Gln Thr Tyr Arg Val Phe Lys Arg Ile Leu Thr Arg Gly Asp His 
        355                 360                 365             


Gly Gly Pro Gln Ser Glu Leu Tyr Met Glu Gln Arg Pro Cys Met Tyr 
    370                 375                 380                 


Arg Ile Ile His Asn Val Ser Lys Ile Ile Asn Gln Thr Ser Gly Ser 
385                 390                 395                 400 


Trp Ile Ile Gly Gln Leu Phe Asp Gly Thr Pro Val Gln Leu Asn Asn 
                405                 410                 415     


Ser Ile Phe Asp Arg Pro Asn Tyr Leu Asn Gln Ser Asp Gly Arg Ser 
            420                 425                 430         


Arg Asp Gly Trp Tyr Val Leu Ser Tyr Asn Gly Leu Ile Lys Tyr Arg 
        435                 440                 445             


Thr Thr Leu Tyr Thr Pro Ser Ala Val Glu Asn Gly Ala Glu Gly Leu 
    450                 455                 460                 


Gly Phe Phe Lys Asp Arg Thr Asn Leu Leu Leu Leu Asp Ser Pro Arg 
465                 470                 475                 480 


Thr Val Ala Ile Ser Asn Gln Met Glu Leu Val Asn Asn Ile Tyr Thr 
                485                 490                 495     


Ser Ile Phe His Ser Asn Thr Thr Ser Val Phe Ser Lys Val Glu Ser 
            500                 505                 510         


Ala Ile Arg Ala Ala Lys Asn Ala Val Ala Ser Tyr Phe Ser Gln Leu 
        515                 520                 525             


Thr Asn Ile Ala Trp Trp Val Gly Thr Gly Cys Ile Gly Ile Ile Ala 
    530                 535                 540                 


Leu Leu Ile Trp Lys Arg Cys His Cys Tyr Asn Leu Leu Cys Lys Lys 
545                 550                 555                 560 


Thr Ser Gln Pro Ala Gly Glu Asn Ser Ser Phe His Val Tyr Asp Thr 
                565                 570                 575     


Ile Glu Met Arg Pro Arg Lys Thr Val Ser Thr Lys Asn His Pro Pro 
            580                 585                 590         


Lys Pro Pro Pro Lys Lys Ala His Gly Lys Ser Gln Gly His Ser Tyr 
        595                 600                 605             


Phe Gln Tyr 
    610     


<210>  494
<211>  623
<212>  PRT
<213>  Ord River hapavirus

<400>  494

Met Phe Trp Ile Lys Phe Leu Val Phe Ile Arg Ala Ser Leu Ile Thr 
1               5                   10                  15      


Thr Lys Gly Tyr Ile Leu Pro Gly Gly Val Gly Gly Val Arg Ser Ser 
            20                  25                  30          


Lys Val His Ile Leu Gly Glu Ile Val Pro Tyr Thr Ser Ser Ile Asp 
        35                  40                  45              


His Gly Val Leu Gly Thr Lys Trp Asp Phe Arg His Asn Asp Gly His 
    50                  55                  60                  


Arg Thr Val Leu Pro Thr His Cys His Arg Thr Trp Lys Asp Val Leu 
65                  70                  75                  80  


Ile Gly Asn Ile Arg Cys Pro Ser Arg Lys Val Ile Gly Lys Glu Gly 
                85                  90                  95      


Leu Tyr Asn Thr Tyr Ile Gly Asp Val Trp His Pro His Thr Asp Ser 
            100                 105                 110         


Gly Ser Glu Ile Lys Gly Phe Leu Cys Gln Lys Thr Arg Trp Val Ser 
        115                 120                 125             


Thr Cys Thr Glu Thr Trp Tyr Phe Ser Thr Thr Lys Glu Thr Gln Ile 
    130                 135                 140                 


Asp Glu Ile Pro Ile Ser Lys Asp Asp Cys Leu Ala Ala Ile Thr Leu 
145                 150                 155                 160 


Val Asp Ser Gly Glu Tyr Ile Glu Pro Phe Phe Pro Pro His Val Cys 
                165                 170                 175     


Ser Trp Ala Ser Thr Asn Lys Asn Thr Lys Asp Phe Val Thr Val His 
            180                 185                 190         


Asn His Pro Val Leu Ile Asp Ile Tyr Lys Asn Gln Leu Met Asp Pro 
        195                 200                 205             


Ile Phe Ile Ser Gly Lys Cys Ser Asp Lys Val Cys Lys Thr Ile His 
    210                 215                 220                 


Lys Asn Val Ile Trp Ile Glu Ala Asn Asp Asn Glu Arg Ser Asp Leu 
225                 230                 235                 240 


Cys Val Ala Ser Ala Trp Glu Phe Ser His Val Phe Ala Asp Ile Asp 
                245                 250                 255     


Ile Asp His Asn Glu Pro Gly Ile Val Asn Asp Ile Gly Asp Ser Ile 
            260                 265                 270         


Asp Ser Glu Leu Tyr Gly Pro Arg Ser Leu Lys Gly Ala Cys Ile Ile 
        275                 280                 285             


Glu Ile Cys Gly Ile Thr Gly Ile Arg Phe Ala His Gly Glu Trp Trp 
    290                 295                 300                 


Gly Leu Lys Thr Val Ser Asn Lys Ile Ser Phe Thr His Gly Leu Tyr 
305                 310                 315                 320 


His Cys Pro Ala Asn Ser Ser Val Gly Phe Val His Asn Ile Trp Thr 
                325                 330                 335     


Pro Ser Glu Val Val Gly Glu Ile Thr Tyr Arg Glu Gln Lys Cys Leu 
            340                 345                 350         


Asp Val Met Ser Ser Leu Leu Gly His Gln Lys Ile Asn Pro Tyr Glu 
        355                 360                 365             


Leu Ser Tyr Leu Ile Gln Asp Tyr Pro Gly Glu Gly Pro Ala Tyr Arg 
    370                 375                 380                 


Ile Met Lys Gln Phe Thr Gly Lys Asn Arg Thr Lys Ser Thr Val Arg 
385                 390                 395                 400 


Leu Gln Met Lys Met Cys Arg Tyr His Val Ala Tyr Ile Lys Asn Val 
                405                 410                 415     


Ser Phe Leu Pro Thr Asp Glu Ser His Glu Ile Tyr Glu Ile Gly Thr 
            420                 425                 430         


Trp Gly Asn Gly Asn Lys Ile Ile Leu Asn Ser Ser Glu Val Gly Ile 
        435                 440                 445             


Asp Pro Ser Tyr Asn Gly Ser Asp Asn Asp Trp Glu Leu Leu Leu Thr 
    450                 455                 460                 


Phe Asn Gly Leu Met Arg Phe Gly Lys Glu Leu Val Leu Pro Gln Ala 
465                 470                 475                 480 


Val Phe Thr Asp His Pro Asn Val Ser Asn Ile Leu Glu Asp Tyr Glu 
                485                 490                 495     


Ile Asn Leu Ile Gly His Pro Lys Glu Ile Phe Gln Glu Ile Gln Asp 
            500                 505                 510         


Glu Leu Ser Gln Val Tyr Lys Phe Tyr Glu Arg Ser Asn Ser Thr Asn 
        515                 520                 525             


Ile Val Gln Leu Ala Gly Asn Val Val Lys Ser Ile Gly Lys Ser Ile 
    530                 535                 540                 


Gly Asn Phe Phe Gly Gly Thr Arg Asn Leu Met Trp Trp Leu Val Thr 
545                 550                 555                 560 


Ile Val Leu Ser Thr Leu Gly Thr Phe Ile Ala Tyr Lys Leu Gly Leu 
                565                 570                 575     


Phe Asn Phe Ile Lys Arg Met Ile Leu Ser Asp Thr Leu Lys Lys Glu 
            580                 585                 590         


Glu Lys Arg Leu Ser Asn Ile Tyr Glu Glu Pro Leu Lys Leu Gly Glu 
        595                 600                 605             


Arg Lys Ala Asn Leu Val Arg Asn Pro Phe Phe Asp His Gly Ile 
    610                 615                 620             


<210>  495
<211>  630
<212>  PRT
<213>  Parry Creek hapavirus

<400>  495

Met Ser Asn Asn Lys Met Phe Lys Pro Met Ile Ile Phe Ala Leu Ile 
1               5                   10                  15      


Leu Cys Leu Ile Ile Asn Val Ser Ser Tyr Ile Tyr Ser Gly Ser Val 
            20                  25                  30          


Gly Gly Tyr Arg Pro Lys Lys Val Arg Thr Tyr Gly Glu Val Ile Pro 
        35                  40                  45              


Tyr Thr Glu Ile Val Glu His Arg Asn Leu Tyr Gln Asn Trp Asn Gly 
    50                  55                  60                  


Lys His Arg Thr Gly His Arg Thr Val Leu Pro Thr His Cys His Thr 
65                  70                  75                  80  


Glu Trp Lys Asp Val Thr His Gly Ser Ile Lys Cys Pro His Arg Lys 
                85                  90                  95      


Val Ile Gly Thr Asp Gly Ile Tyr Asn Thr Tyr Ile Gly Asp Val Trp 
            100                 105                 110         


His Pro His Thr Asp Ser Gly Ser Glu Ile Lys Gly Phe Leu Cys Gln 
        115                 120                 125             


Lys Thr Arg Trp Val Ser Thr Cys Ile Glu Thr Trp Tyr Phe Ser Thr 
    130                 135                 140                 


Thr Lys Glu Thr Lys Ile Glu Glu Val Val Ile Asn Pro Glu Asp Cys 
145                 150                 155                 160 


Leu Ala Ser Ile Thr Leu Met Asp Ser Gly Glu Tyr Ile Glu Pro Phe 
                165                 170                 175     


Phe Pro Pro His Val Cys Ser Trp Ala Ala Thr Asn Glu Asn Ala Lys 
            180                 185                 190         


Glu Phe Val Thr Val His Ser His Pro Val Val Val Asp Ile Tyr Lys 
        195                 200                 205             


Asn Glu Met Ile Asp Pro Ile Phe Leu Ser Gly Lys Cys Lys Glu Lys 
    210                 215                 220                 


Val Cys His Thr Ile His Lys Asn Val Ile Trp Ile Glu Ala Asn Asp 
225                 230                 235                 240 


Asn Glu Arg Ser Asp Ile Cys Val Ala Ser Ala Trp Glu Ser Ser His 
                245                 250                 255     


Val Phe Ala Asp Leu Asp Ile Glu Pro Asp Ile Arg Ala Gln Lys Val 
            260                 265                 270         


Glu Tyr Ile Gly Glu Ser Ile Asp Ser Glu Ile Tyr Gly Pro Arg Ser 
        275                 280                 285             


Leu Lys Gly Ala Cys Leu Ile Lys Ile Cys Gly Ile Trp Gly Ile Arg 
    290                 295                 300                 


Phe Ser His Gly Glu Trp Trp Gly Leu Lys Thr Leu Ser Asn Lys Ile 
305                 310                 315                 320 


Ser Phe Ala Asp Gly Leu Tyr Asn Cys Gly Ser Asn Thr Ser Val Gly 
                325                 330                 335     


Phe Ile His Asn Ile Trp Thr Pro Ser Gly Leu Ile Gly Glu Ile Thr 
            340                 345                 350         


Tyr Arg Asp His Lys Cys Leu Asp Val Val Ser Ser Leu Leu Gly His 
        355                 360                 365             


Gln Lys Ile Asn Pro Tyr Glu Leu Ser Tyr Leu Ile Gln Asp Phe Pro 
    370                 375                 380                 


Gly Glu Gly Pro Ala Tyr Arg Ile Met Lys Gln Met Thr Gly Leu Asn 
385                 390                 395                 400 


Arg Thr Lys Ser Ser Phe Lys Met Gln Met Lys Thr Cys Arg Tyr His 
                405                 410                 415     


Thr Ala Tyr Ile Thr Asn Val Thr Phe Gln Pro Ile Asp Ser Thr Gln 
            420                 425                 430         


Glu Val Tyr Lys Leu Gly Ile Trp Gly Ser Gly His Arg Ile Ile Leu 
        435                 440                 445             


Asn Ser Thr Glu Ile Gly Ile Asn Pro Thr Tyr Thr Asn Ser Gly Ser 
    450                 455                 460                 


Asp Trp Glu Leu Leu Leu Thr Phe Asn Gly Leu Met Arg Phe Gly Ser 
465                 470                 475                 480 


Glu Leu Val Leu Pro His Ala Val Phe Ser Asp His Pro Asn Thr Ser 
                485                 490                 495     


Asp Leu Leu Glu Asp Tyr Glu Ile Asn Leu Ile Gly His Pro Lys Glu 
            500                 505                 510         


Ile Phe Gln Ser Asp Gln Asp Glu Leu Ala Gln Ile Tyr Lys Phe Tyr 
        515                 520                 525             


Arg Arg Ala Asn Ser Thr Asn Val Val Ser Leu Ala Ser Asn Phe Leu 
    530                 535                 540                 


Lys Asp Ile Gly Lys Ser Ile Gly Asn Phe Phe Gly Gly Thr Lys Asn 
545                 550                 555                 560 


Leu Ile Trp Trp Ile Val Thr Leu Ala Leu Ser Thr Leu Gly Thr Phe 
                565                 570                 575     


Ile Ala Tyr Lys Leu Gly Leu Phe Lys Cys Leu Lys Arg Met Ile Leu 
            580                 585                 590         


Glu Thr Asp Asn Glu Ser Gly Asn Lys Arg Ile Ser Asn Val Tyr Glu 
        595                 600                 605             


Glu Pro Leu Gln Leu Gly Glu Arg Gly His Lys Pro Val Lys Asn Pro 
    610                 615                 620                 


Phe Phe Asp His Gly Ile 
625                 630 


<210>  496
<211>  623
<212>  PRT
<213>  Wongabel hapavirus

<400>  496

Met Ser Phe Leu Leu Ala Ile Ile Ile Phe Phe Phe Arg Thr Gln Asp 
1               5                   10                  15      


Ser Asn Gly Tyr Val Val Gln Ser Gly Ile Gly Gly Ile Arg Glu Ser 
            20                  25                  30          


Lys Val Asn Ile Leu Gly Gln Val Val Pro Tyr Ser Thr Lys Phe Lys 
        35                  40                  45              


His Ser Val Leu Lys Ser Gln Trp Asp Tyr Arg His Asp Lys Gly His 
    50                  55                  60                  


Arg Thr Val Leu Pro Thr Asn Cys His Ala Thr Trp Asn Asp Ile Thr 
65                  70                  75                  80  


Pro Ser Asn Met Arg Cys Pro Arg Arg Lys Ile Ile Gly Lys Asp Gly 
                85                  90                  95      


Leu Tyr Asn Thr Tyr Ile Gly Asp Phe Trp His Pro His Thr Asp Lys 
            100                 105                 110         


Gly Ser Glu Val Lys Gly Phe Ile Cys Gln Lys Thr Lys Trp Val Ser 
        115                 120                 125             


Thr Cys Ile Glu Thr Trp Tyr Phe Ser Thr Thr Lys Glu Thr Gln Ile 
    130                 135                 140                 


Asp Glu Val Pro Ile Thr Lys Glu Asp Cys Leu Ala Ala Ile Thr Leu 
145                 150                 155                 160 


Val Asp Ser Gly Glu Tyr Ile Glu Pro Phe Phe Pro Pro His Val Cys 
                165                 170                 175     


Ser Trp Ala Ser Thr Asn Lys Asn Ser Lys Glu Phe Val Thr Val His 
            180                 185                 190         


Glu His Ser Val Val Leu Asp Ile Tyr Glu Asn Lys Leu Met Asp Pro 
        195                 200                 205             


Ile Phe Leu Ala Gly Lys Cys Phe Asp Lys Val Cys Lys Thr Ile His 
    210                 215                 220                 


Arg Asn Val Leu Trp Val Glu Ala Asn Asp Asn Glu Arg Asp Asp Phe 
225                 230                 235                 240 


Cys Val Ala Thr Ala Trp Glu Tyr Ser His Val Phe Ala Asp Ile Asp 
                245                 250                 255     


Ile Asp His Asn Asn Asn His Pro Ile Tyr Ser Ile Gly Lys Thr Ile 
            260                 265                 270         


Asp Ser Glu Ile Tyr Gly Pro Arg Asp Leu Ala Asp Ala Cys Ile Ile 
        275                 280                 285             


Lys Ile Cys Gly Ile Pro Gly Ile Arg Phe Ser His Gly Glu Trp Trp 
    290                 295                 300                 


Gly Ile Lys Thr Leu Ser Asp Arg Ile Pro Leu Glu Asp Ile Ile Ile 
305                 310                 315                 320 


Lys Cys His Asn Gly Thr Ser Val Gly Phe Val His Asn Ile Trp Thr 
                325                 330                 335     


Pro Ser Glu Leu Val Gly Glu Ile Thr Tyr Arg Asp His Lys Cys Leu 
            340                 345                 350         


Asp Val Leu Ser Ser Phe Leu Gly Gln Arg Lys Ile Asn Pro Tyr Glu 
        355                 360                 365             


Leu Ser Tyr Leu Val Gln Asp Phe Pro Gly Glu Gly Pro Ala Tyr Arg 
    370                 375                 380                 


Ile Met Lys Gln Tyr Thr Gly Asn Asn Lys Thr Lys Ala Thr Phe Arg 
385                 390                 395                 400 


Leu Gln Thr Lys Thr Cys Arg Tyr His Val Ala Tyr Ile Asp Lys Leu 
                405                 410                 415     


Thr Phe Asp Pro Glu Asn Gly Thr Asp Glu Val Tyr Lys Leu Gly Thr 
            420                 425                 430         


Trp Gly Asn Gly Arg Thr Val Ile Leu Asn Ser Thr Glu Val Gly Ile 
        435                 440                 445             


Asn Pro Thr Tyr Ile Asn Lys Ser Phe Asp Trp Glu Pro Leu Glu Thr 
    450                 455                 460                 


Phe Asn Gly Leu Met Arg Phe Gly Ala Glu Leu Val Leu Pro Gln Ala 
465                 470                 475                 480 


Val Tyr Thr Asp His Pro Asn Ile Thr Asn Leu Leu Glu Asp Tyr Glu 
                485                 490                 495     


Ile Ser Leu Ile Gly His Pro Lys Glu Ile Phe Glu Pro Glu Gln Asp 
            500                 505                 510         


Glu Leu Ser Gln Val Tyr Lys Phe Tyr Glu Arg Ser Asn Ser Thr Asn 
        515                 520                 525             


Val Val Gly Leu Ala Ser Asn Phe Val Lys Thr Ile Gly Arg Ser Ile 
    530                 535                 540                 


Gly Asn Phe Phe Gly Gly Thr Lys Asn Leu Ile Trp Trp Leu Val Thr 
545                 550                 555                 560 


Val Ala Leu Ser Thr Ile Gly Thr Tyr Ile Ala Tyr Lys Leu Gly Leu 
                565                 570                 575     


Phe Lys Phe Leu Gly Arg Ile Leu Phe Gln Gly Ser Glu Ser Lys Glu 
            580                 585                 590         


Asp Lys Arg Val Ser Asn Ile Tyr Glu Glu Pro Leu Lys Leu Gly Gly 
        595                 600                 605             


Arg Arg Ser His Leu Val Lys Asn Pro Phe Phe Asp Asn Gly Ile 
    610                 615                 620             


<210>  497
<211>  543
<212>  PRT
<213>  Barur ledantevirus

<400>  497

Met Asp Phe Trp Met Leu Ile Cys Val Leu Ala Ala Val Ala Gln Ala 
1               5                   10                  15      


Arg His Asp Tyr Ser Tyr Glu Gly Lys Thr Lys Asp Ile Ile Gly Leu 
            20                  25                  30          


Ile Pro Asn Asp Lys Lys Leu His Trp Lys Thr Thr Lys Leu Asp Ala 
        35                  40                  45              


Ile Arg Cys Pro Glu Met Gly Leu Val Ser Asn Lys Gly Glu Gln Val 
    50                  55                  60                  


Val Glu Arg Trp Ile Ile Glu Arg Pro Arg Thr Thr Gly Glu Leu Lys 
65                  70                  75                  80  


Asn Lys Gly Lys Leu Cys His Leu Ala Lys Trp Val Thr Lys Cys Glu 
                85                  90                  95      


Tyr Thr Trp Tyr Phe Ser Lys Thr Val Ser Arg Thr Ile Gln Asn Leu 
            100                 105                 110         


Glu Ala His Glu Ala Asp Cys Lys Gln Ala Ile Gln Asp Tyr Asn Lys 
        115                 120                 125             


Gly Ile Leu Thr Pro Asp Ser Phe Pro Pro Glu Ala Cys Tyr Trp Ala 
    130                 135                 140                 


Ser Thr Asn Glu Glu Ser Val Thr Ala Phe Thr Ile Thr Pro His Glu 
145                 150                 155                 160 


Val Thr Tyr Asp Pro Tyr Glu Asp Arg Tyr Leu Asp Pro Leu Phe Val 
                165                 170                 175     


His Gly Ser Cys His Thr Asp Phe Cys Glu Thr Val Tyr Glu Ser Thr 
            180                 185                 190         


Val Trp Leu Thr Asp Ser Pro Gly Ser Gln Ser Ser Cys Lys Leu Val 
        195                 200                 205             


Gly Asp Glu Pro Val Glu Ile Leu Glu Ser Tyr Arg Arg Asn Lys Ala 
    210                 215                 220                 


Gly Asp Tyr Lys Phe Gly Phe Trp Met Arg Gly Ser His Ile His His 
225                 230                 235                 240 


Met Pro Val Ser His Leu Cys Lys Lys Glu Tyr Cys Gly Arg Leu Gly 
                245                 250                 255     


Tyr Val Asn Gln Gln Gly Val Trp Phe His Val Thr Ser Val Lys Trp 
            260                 265                 270         


Ser Tyr Asn Glu Thr Ile Ser Phe Arg His Leu Ile Asp Asn Cys Pro 
        275                 280                 285             


Gln Ser Ser Asp Leu Val Val Leu Asp Glu Glu Phe Asn Asp Asp Asp 
    290                 295                 300                 


Leu Val Ala Thr Met Glu Glu Met Met Trp Asp Ile Asn Cys Leu Asn 
305                 310                 315                 320 


Ala Val Glu Asn Ile Gln Lys His Arg Arg Ala Ser Leu His Asp Leu 
                325                 330                 335     


Tyr Gln Ile Ser Gln Arg His Pro Gly Pro Gly Val Ala Tyr Arg Leu 
            340                 345                 350         


Lys Asn Gly His Leu Glu Ser Ala Gln Ala Ser Phe Val Ala Leu Tyr 
        355                 360                 365             


Ala Pro Glu Asp His Val Gln Thr Arg Glu Cys Leu Gly Thr Ile Leu 
    370                 375                 380                 


Asp Ser Lys His Asp Arg Cys His Ser Trp Glu Asp Trp Thr His Ile 
385                 390                 395                 400 


Ala Asn Ser Thr Tyr His Ala Val Asn Gly Ile Thr Glu Val Asp Gly 
                405                 410                 415     


Lys Ile Val Phe Pro Glu Phe Arg Val Leu Lys Arg Arg Trp Asp Leu 
            420                 425                 430         


Glu Tyr Ser Leu Lys His Asp Leu Lys Gln Ile Asn His Pro Val Ile 
        435                 440                 445             


His Asp Ile Thr Gly Lys Val His Glu Asn Ile Val His Lys Glu Ile 
    450                 455                 460                 


Lys Ser His Ser Val Asn Ala Gly Asp Leu Ile Gly Asn Trp Val Thr 
465                 470                 475                 480 


Val Ala Glu Ser Lys Ile Gly Glu Phe Phe Lys Gly Phe Ser His Ser 
                485                 490                 495     


Phe Val Thr Ile Ser Val Phe Leu Ile Thr Val Leu Ala Ile Trp Ile 
            500                 505                 510         


Ile Val Arg Cys Cys Gln Met Cys Gln Arg Lys Lys Pro Thr Lys Ile 
        515                 520                 525             


Asn Ser Ala Lys Asp Asp Ile Pro Met Val Thr Thr Ser Phe Gly 
    530                 535                 540             


<210>  498
<211>  548
<212>  PRT
<213>  Bughendera ledantevirus

<400>  498

Met Lys Lys Thr Thr Arg Asn Asn Asn Phe Ile Asn Met Ile Lys Tyr 
1               5                   10                  15      


Ile Ile Ile Leu Leu Ser Met Phe Arg Leu Met Gly Gly Val Thr Lys 
            20                  25                  30          


Leu Ser Pro Tyr Arg Asn Leu Leu Leu Pro Ile Asn Ser His Ser Glu 
        35                  40                  45              


Trp Lys Pro Val Asn Leu Ala Asn Leu Thr Cys Pro Lys Pro Lys Leu 
    50                  55                  60                  


Asp Trp Thr Ile Asp Phe His Gln Leu Ala Thr Glu Gln Val Tyr Arg 
65                  70                  75                  80  


Leu Arg Asp Leu Ser Ile Gly Glu Ile Lys Gly Tyr Leu Cys His Lys 
                85                  90                  95      


Ala Glu Trp Ile Thr Arg Cys Glu Tyr Ser Trp Tyr Leu Ser Lys Thr 
            100                 105                 110         


Val Ser Arg Arg Ile Arg Glu Leu Ser Pro Ser Gln Ser Glu Cys Glu 
        115                 120                 125             


Asp Gly Ile His Tyr Ile Lys Glu Gly Arg Glu Thr Ser Gly Ser Phe 
    130                 135                 140                 


Pro Pro Glu Glu Cys Tyr Trp Asn Ser Val Asn Asp Glu Ser Glu Val 
145                 150                 155                 160 


Lys Ile Ile Leu Thr Pro His Ser Leu Thr Tyr Asp Pro Tyr Thr Asp 
                165                 170                 175     


Arg Gly Leu Asp Ala Asn Leu Leu Gly Gly Phe Cys Lys Ser Arg Tyr 
            180                 185                 190         


Cys Gln Thr Thr His Ser Ser Val Met Trp Ile Gln Asp Pro Glu Ser 
        195                 200                 205             


His Thr Glu Pro Cys Thr His Met Ile Ala Glu Lys Leu Thr Val Leu 
    210                 215                 220                 


Ser Ser Lys Gln Gly Glu Thr Gly Lys Arg Trp Val Lys Thr Thr Ala 
225                 230                 235                 240 


Thr Pro Ala Met Ser Leu Glu Lys Ala Cys Lys Leu Arg Tyr Cys Gly 
                245                 250                 255     


Val Glu Gly Ile Leu Leu Ala Ser Gly Leu Trp Phe Gly Leu Pro Glu 
            260                 265                 270         


Glu Ser Ile Glu Gly His Asp Asn Leu Gly Val Lys Glu Val Cys Ala 
        275                 280                 285             


Ala Ser Ser Glu Val Gly Val Leu Gln Pro Asp Tyr Phe Asp Lys Ser 
    290                 295                 300                 


Leu Glu Phe Lys Met Glu Asp Leu Gln Arg Glu Ile Leu Cys Leu Gln 
305                 310                 315                 320 


Leu Leu Asp Lys Ile Lys Ile Gln Lys Ile Val Asn Met Phe Asp Leu 
                325                 330                 335     


Gln Tyr Leu Arg Pro His Ser Pro Gly Phe Gly His Val Tyr Gln Val 
            340                 345                 350         


Val Asn Gly Thr Leu Met Ser Ala Ser Ala Gln Tyr Ala Ile Thr Thr 
        355                 360                 365             


Tyr Pro Gly Glu Lys Thr Ile Ser Arg Lys Cys Leu Gly Gln Phe Lys 
    370                 375                 380                 


Asp Pro Ser Leu Asn Thr Leu Cys Val Asn Trp Ser Ser Trp Leu Pro 
385                 390                 395                 400 


Met Lys Asp Gly Val Tyr Gln Ala Phe Asn Gly Ile Ile Glu Lys Asp 
                405                 410                 415     


Gly Val Ile Leu Leu Pro Glu Asp Gln Leu Leu Glu Ala Thr Trp Ser 
            420                 425                 430         


Pro Asp Met Phe Asp Tyr Ile Pro Leu Asp Lys Ile His His Pro Val 
        435                 440                 445             


Tyr Ile Asn Ile Ser Asp Ile Ile His Asp Gly Val Asp Glu Gly Leu 
    450                 455                 460                 


Ile His Asp Lys Thr Glu Asn Pro Gly Asp Thr Leu Ser Gly Trp Val 
465                 470                 475                 480 


Thr Ile Ala Lys Asn Lys Val Leu Ile Phe Phe Glu Thr Ile Gly Glu 
                485                 490                 495     


Ser Leu Leu Ile Ile Ile Met Ile Val Ile Leu Ala Trp Ile Leu Leu 
            500                 505                 510         


Arg Leu Ile Lys Leu Ser Ile Met Cys Val Lys Asn Arg Gly Thr Arg 
        515                 520                 525             


Asn Asp Arg Tyr Glu Glu Asp Gly Asn Tyr Phe Lys Asn Arg Gln Leu 
    530                 535                 540                 


Asn Val Phe Gly 
545             


<210>  499
<211>  549
<212>  PRT
<213>  Fikirini ledantevirus

<400>  499

Met Gly Phe Leu Ile Val Leu Cys Leu Ser Val Ala Leu Gly His Leu 
1               5                   10                  15      


Glu Asp Arg Asn His Thr Pro Ala Pro Phe Tyr Glu Pro Ser Asp Ser 
            20                  25                  30          


Glu Lys Glu Leu Arg Met Asp Gly Glu Ile Leu Phe Pro Val Thr Val 
        35                  40                  45              


Gly Glu Val Trp Lys Pro Val Pro Leu Ser Thr Leu Arg Cys Pro Lys 
    50                  55                  60                  


Arg Ala Lys Arg Gly Ser Gln Phe Gly Lys Thr Tyr Lys Val Phe Asn 
65                  70                  75                  80  


Leu Thr Arg Tyr Glu Ser Phe Lys Pro Gly Ser Val Ser Gly Tyr Leu 
                85                  90                  95      


Cys His Lys Ile Lys Trp Val Thr Lys Cys Ser Glu Thr Trp Tyr Phe 
            100                 105                 110         


Ala Lys Glu Val Ser Arg His Val Glu Pro Val Leu Pro Thr Glu Asp 
        115                 120                 125             


Glu Cys Lys Met Ala Met Lys Ala Glu Gln Ser Gly Leu Ser Glu Ser 
    130                 135                 140                 


Gly Ser Tyr Pro Pro Glu Glu Cys Tyr Trp Asn Ala Val Asn Glu Glu 
145                 150                 155                 160 


Val Asn Thr Glu Val His Leu Thr Val His Pro Thr Gly Leu Asp Pro 
                165                 170                 175     


Tyr Thr Met Glu Trp Val Asp Glu Ile Phe Leu Lys Gly Arg Cys Ser 
            180                 185                 190         


His Asp Tyr Cys Glu Thr Asp His Ser Thr Val Thr Trp Ile Arg Asp 
        195                 200                 205             


Ala Glu Lys Thr Asn His Val Arg Cys Gly Asp Lys Val Val Glu His 
    210                 215                 220                 


Ala Glu Leu Ser Leu Ile Asp Gly Thr Ser Ser Pro Ser Lys Leu Ser 
225                 230                 235                 240 


Asp Leu Ala Val Ile Ser His His Ile Pro Leu Ser Ser Leu Ala Asp 
                245                 250                 255     


Ser Cys Glu Leu Thr Phe Cys Gly Glu Glu Gly Ile Gln Leu Ala Asn 
            260                 265                 270         


Gly Ile Trp Phe Gln Thr Pro Asn Leu Ala Gly Leu Gly Val Asp Tyr 
        275                 280                 285             


Leu Ser Glu Cys Pro Ser Asn Thr Lys Ala Gly Met Ile Ser Gln Asp 
    290                 295                 300                 


Tyr Lys Glu Asp Glu Ile Ile Tyr Asp Met Glu Glu Ile Arg Gln Asp 
305                 310                 315                 320 


Val Glu Cys Leu Asn Thr Leu Glu Ser Ile Gln Ala Thr Gly Thr Ile 
                325                 330                 335     


Thr Tyr Arg Gly Leu Gln Tyr Phe Gln Pro Arg Ser Val Gly Val His 
            340                 345                 350         


Pro Val Tyr Arg Ile Arg Asn Ser Thr Val Glu Thr Asn Thr Ala Lys 
        355                 360                 365             


Tyr Val Leu Ala Phe Ile Pro Asp Thr Glu Pro Asn Ser Ser Cys Ile 
    370                 375                 380                 


Gly Val Ile Thr Glu Asn Arg Arg Pro Arg Cys Leu Ala Trp Asn Glu 
385                 390                 395                 400 


Trp Leu Asp Glu Gly Asn Gly Leu Tyr Gln Gly Phe Asn Gly Leu Met 
                405                 410                 415     


Leu Asp Lys Gly Lys Ile Leu Tyr Pro Ile Arg Tyr Leu Leu Asp Ala 
            420                 425                 430         


Asp Trp Asn Pro Glu Met His Val Leu Arg Tyr Val Thr Tyr Ser Pro 
        435                 440                 445             


His Pro Leu Leu His Glu Tyr Ala Arg Gln Val Ile Asp Glu Gly Arg 
    450                 455                 460                 


Asn Glu Val Val Lys Asp Gly Ser Lys Asn Ile Gly Asp Ala Val Ala 
465                 470                 475                 480 


Glu Thr Ala Glu Ser Leu Ser Asn Arg Leu Thr Thr Phe Phe Gln Lys 
                485                 490                 495     


Phe Thr Ser Gln Leu Ser Gly Ile Val Gly Ile Leu Ala Ile Leu Met 
            500                 505                 510         


Ile Ser Tyr Gly Ile Phe Lys Ile Ala Arg Arg Val Lys Lys Ala Lys 
        515                 520                 525             


Arg Pro Val Met Val Lys Pro Gln Glu Ile Glu Met Glu Thr Ser Glu 
    530                 535                 540                 


Gly Glu Gly Phe Gly 
545                 


<210>  500
<211>  543
<212>  PRT
<213>  Fukuoka ledantevirus

<400>  500

Met Asp Phe Trp Met Ile Ile Tyr Val Leu Val Val Ser Ala Ser Ala 
1               5                   10                  15      


Gln Gln Asp Tyr Ser Tyr Gly Gly Lys Thr Lys Asp Ile Ile Gly Leu 
            20                  25                  30          


Leu Pro Gln Asp Lys Lys Leu His Trp Lys Thr Thr Lys Leu Asp Ser 
        35                  40                  45              


Ile Lys Cys Pro Glu Met Gly Leu Ile Ser Asn Lys Glu Glu His Val 
    50                  55                  60                  


Val Glu Lys Trp Leu Ile Glu Arg Pro Arg Thr Thr Gly Lys Leu Arg 
65                  70                  75                  80  


Asn Lys Gly Lys Leu Cys His Leu Ala Lys Trp Ile Thr Lys Cys Glu 
                85                  90                  95      


Tyr Thr Trp Tyr Phe Ser Lys Thr Val Ser Arg Thr Ile Gln Asn Leu 
            100                 105                 110         


Glu Ala His Glu Asp Asp Cys Lys Gln Ala Ile Arg Glu Tyr Asn Gln 
        115                 120                 125             


Gly Lys Leu Ile Pro Gly Ser Phe Pro Pro Glu Ser Cys Tyr Trp Ala 
    130                 135                 140                 


Ser Thr Asn Glu Glu Ser Val Ile Ala His Ile Ile Thr Pro His Glu 
145                 150                 155                 160 


Val Thr Tyr Asp Pro Tyr Glu Asp Arg Tyr Leu Asp Pro Leu Phe Val 
                165                 170                 175     


His Gly Phe Cys Arg Thr Ser Phe Cys Glu Thr Val Tyr Glu Ser Thr 
            180                 185                 190         


Val Trp Leu Thr Asp Ser Pro Gly Arg Gln Ser Ser Cys Lys Leu Glu 
        195                 200                 205             


Gly Asp Glu Pro Val Glu Val Leu Glu Ser Tyr Arg His Asn Lys Ala 
    210                 215                 220                 


Gly Glu Ser Lys Phe Gly Phe Trp Met Arg Gly Ser His Ile His His 
225                 230                 235                 240 


Met Pro Leu Ser Arg Leu Cys Lys Lys Glu Tyr Cys Gly Lys Leu Gly 
                245                 250                 255     


Tyr Val Asn Gln Gln Gly Val Trp Phe His Val Thr Ser Val Gln Trp 
            260                 265                 270         


Ser Tyr Asn Glu Ser Ile Ser Phe Arg His Val Val Glu Asn Cys Thr 
        275                 280                 285             


Glu Ser Pro Asp Leu Val Val Leu Ser Glu Glu Phe Asn Asp Asp Asp 
    290                 295                 300                 


Leu Ala Ala Thr Leu Glu Glu Met Met Trp Asp Ile Asn Cys Leu Asn 
305                 310                 315                 320 


Ala Val Glu Asn Ile Gln Lys His Lys Arg Ala Ser Leu His Asp Leu 
                325                 330                 335     


Tyr Gln Ile Ser Gln Arg His Pro Gly Pro Gly Thr Ala Tyr Arg Leu 
            340                 345                 350         


Lys Asp Gly His Leu Glu Ser Ala Gln Ala Asn Phe Val Ala Leu Tyr 
        355                 360                 365             


Ala Pro Asp Glu His Glu Gln Asn Arg Glu Cys Leu Gly Thr Val Leu 
    370                 375                 380                 


Asp His Thr Gly Asp Gln Cys His Ala Trp Asp Asp Trp Thr His Ile 
385                 390                 395                 400 


Ala Asn Ser Thr Tyr His Ala Val Asn Gly Ile Thr Glu Val Asp Gly 
                405                 410                 415     


Lys Ile Val Phe Pro Glu Tyr Arg Val Leu Lys Arg Arg Trp Asp Leu 
            420                 425                 430         


Glu Tyr Ser Leu Lys His Asp Leu Arg Gln Ile Asn His Pro Val Ile 
        435                 440                 445             


Ser Asp Phe Val Gly Lys Val His Glu Asn Ile Val His Lys Glu Ile 
    450                 455                 460                 


Lys Ser His Ser Val Asn Ala Gly Asp Leu Ile Gly Asn Trp Val Thr 
465                 470                 475                 480 


Val Ala Glu Ser Lys Ile Gly Glu Phe Phe Lys Gly Phe Ser His Ser 
                485                 490                 495     


Phe Val Thr Ile Ser Val Phe Leu Met Val Val Leu Thr Ile Trp Ile 
            500                 505                 510         


Ile Ile Arg Cys Cys Gln Met Cys Lys Arg Glu Lys Pro Thr Lys Ile 
        515                 520                 525             


Ile Ser Ala Lys Asp Asp Ile Pro Met Val Thr Ser Ser Phe Gly 
    530                 535                 540             


<210>  501
<211>  548
<212>  PRT
<213>  Kanyawara ledantevirus

<400>  501

Met Lys Lys Thr Thr Arg Tyr Tyr Pro Thr Thr Asn Met His Ala Asn 
1               5                   10                  15      


Leu Val His Phe Thr Leu Leu Val Ala Ser Val Gln Cys Val Thr Lys 
            20                  25                  30          


Leu Ser Gln Tyr Arg Asn Leu Leu Leu Pro Ile Asn Val His Ser Asp 
        35                  40                  45              


Trp Lys Pro Val Glu Ile His Asn Leu Thr Cys Pro Lys Pro Arg Leu 
    50                  55                  60                  


Asp Trp Thr Val Asp Phe His Gln Leu Ala Thr Glu Gln Val Tyr Arg 
65                  70                  75                  80  


Leu Lys Asp Leu Ser Leu Gly Glu Val Lys Gly Tyr Leu Cys His Lys 
                85                  90                  95      


Ala Gln Trp Ile Thr Arg Cys Glu Tyr Arg Trp Tyr Leu Ser Gln Val 
            100                 105                 110         


Val Ser Arg Arg Val Lys Glu Glu Thr Pro Thr Gln Ala Glu Cys Glu 
        115                 120                 125             


Glu Ala Ile His His Phe Asn Glu Gly Arg Glu Met Ser Gly Ser Phe 
    130                 135                 140                 


Pro Pro Glu Ala Cys Phe Trp Asn Ala Val Asn Asp Glu Ser Glu Thr 
145                 150                 155                 160 


Lys Ile Ile Leu Thr Val His Asp Leu Thr Tyr Asp Pro Tyr Thr Asp 
                165                 170                 175     


Met Gly Leu Asp Ser Asn Leu Val Gly Gly Thr Cys Lys Ser Arg Phe 
            180                 185                 190         


Cys Lys Thr Thr His Ser Ser Val Met Trp Ile Lys Asp Pro Lys Gly 
        195                 200                 205             


Gln Thr Glu Pro Cys Val His Met Ile Ala Glu Lys Leu Thr Val Leu 
    210                 215                 220                 


Ser Ser Lys Gln Gly Glu Thr Gly Lys Arg Trp Val Lys Thr Thr Ala 
225                 230                 235                 240 


Thr Pro Ala Met Ser Leu Glu Lys Ala Cys Lys Leu Arg Tyr Cys Gly 
                245                 250                 255     


Val Glu Gly Ile Leu Leu Ser Ser Gly Leu Trp Phe Gly Leu Pro Asp 
            260                 265                 270         


Ser Ser Lys Glu His His Asp Asn Leu Gly Ile Arg Asp Asn Cys Pro 
        275                 280                 285             


Thr Asn Ser Glu Val Gly Val Leu Gln Pro Asp Tyr Phe Asp Asn Ser 
    290                 295                 300                 


Met Glu Phe Lys Leu Glu Asp Leu Gln Arg Glu Ile Leu Cys Leu Gln 
305                 310                 315                 320 


Leu Leu Asp Lys Ile Lys Leu Gln Arg Leu Ile Ser Met Phe Asp Leu 
                325                 330                 335     


Gln Tyr Leu Arg Pro His Asn Ser Gly Phe Gly His Val Tyr Gln Val 
            340                 345                 350         


Ile Asn Gln Thr Leu Met Ser Thr His Ala His Tyr Ala Val Thr Thr 
        355                 360                 365             


Tyr Pro Gly Ser Asn Ser Leu Thr Arg Asn Cys Leu Gly Gln Tyr Lys 
    370                 375                 380                 


Asp Ser Ser Met Asn Thr Val Cys Val Asn Trp Ser Ser Trp Leu Pro 
385                 390                 395                 400 


Met Lys Asn Gly Val Tyr Gln Gly Phe Asn Gly Ile Ile Glu Lys Asp 
                405                 410                 415     


Gly Val Ile Leu Phe Pro Glu Asp Gln Leu Leu Glu Ser Ser Trp Asn 
            420                 425                 430         


Pro Asp Met Phe Asp Tyr Ile Pro Leu Asp Lys Ile His His Pro Phe 
        435                 440                 445             


Tyr Phe Asn Met Ser Asp Ile Ile His Asp Asp Ile Asp Glu Arg Leu 
    450                 455                 460                 


Ile His Asp Asn Ser Thr Asn Pro Gly Asp Ala Ile Ser Asp Trp Val 
465                 470                 475                 480 


Thr Val Ala Asn Asn Lys Val Val His Phe Phe Lys Gln Leu Gly Glu 
                485                 490                 495     


Ser Ile Val Ile Ile Ile Leu Ile Ile Leu Gly Ala Asn Leu Thr Tyr 
            500                 505                 510         


Lys Cys Val Lys Leu Cys Ile Arg Trp Arg Phe Gly Leu Lys Ser Lys 
        515                 520                 525             


Lys Thr Gln Phe Leu Glu Glu Gly His Ala Met Asn Met Ala Arg Glu 
    530                 535                 540                 


Thr Val Phe Gly 
545             


<210>  502
<211>  563
<212>  PRT
<213>  Kern Canyon ledantevirus

<400>  502

Met Leu Ile Thr Val Leu Leu Val Ile Ile Val Ser Ser Gln Ala Gln 
1               5                   10                  15      


Ile His Tyr Ser Gly Thr Pro Lys Pro Gly Lys Gly Tyr Val Lys Glu 
            20                  25                  30          


Asp Ser Pro Lys Leu Lys Tyr Asn Asp Val Glu Leu Tyr His Gln Pro 
        35                  40                  45              


Pro Leu Val Leu Pro Leu Glu Asn Asp Arg Glu Trp Arg Ala Ala Asn 
    50                  55                  60                  


Leu Ser Ala Leu Phe Cys Pro Ser Glu Ala Pro Val Gly Pro Asn Glu 
65                  70                  75                  80  


His Ile His Ile Glu Ser Trp Ile Val Thr Arg Pro Arg Gln Gln Ile 
                85                  90                  95      


Lys Asp Pro Val Lys Gly Tyr Leu Cys His Lys Ser Arg Trp Ile Thr 
            100                 105                 110         


Lys Cys Glu Tyr Thr Trp Tyr Leu Ser Lys Thr Ile Ser Arg Lys Ile 
        115                 120                 125             


Glu Pro Leu Pro Pro Ser Lys Gln Glu Cys Glu Glu Ala Arg Arg Lys 
    130                 135                 140                 


Phe Glu Gln Gly Ser Leu Thr His Leu Ser Phe Pro Pro Ala Gly Cys 
145                 150                 155                 160 


Tyr Trp Ala Ser Thr Asn Glu Glu Ser Asn Thr Asp Ile Glu Ile Ser 
                165                 170                 175     


Glu His Pro Ala Thr Tyr Asp Pro Tyr Lys Asp Lys Leu Val Asp Pro 
            180                 185                 190         


Val Phe Val Gly Gly Glu Cys Asp Ser Lys Leu Cys Asp Thr Ile His 
        195                 200                 205             


Asp Ser Thr Ile Trp Ile Glu Ser Asp Arg Asn Pro Arg Pro Glu Gln 
    210                 215                 220                 


Cys Asn Met Asn Glu Glu Glu Gln Leu Asp Val Val Gln Gly Ile Arg 
225                 230                 235                 240 


Ala Val Gly Gly Thr Lys Lys Asn Ser Gln His Ala Ile Trp Val Ile 
                245                 250                 255     


Gly Asn Asn Tyr Pro Tyr Leu Asp Ala Arg Gly Leu Cys Lys Lys Thr 
            260                 265                 270         


Tyr Cys Gly Lys Val Gly Ala Leu Leu Gly Asn Gly Leu Trp Phe His 
        275                 280                 285             


Val Leu His Val Val Asn Gly Thr Gly Gly Asp Thr Val Trp Ser Thr 
    290                 295                 300                 


Ala Arg Ala Cys Ser Lys Glu Glu Glu Ile Gly Ile Leu Gly Glu Glu 
305                 310                 315                 320 


Tyr Glu Ile Glu Ser Leu Gln Ala Thr Met Glu Asp Ile Met Trp Asp 
                325                 330                 335     


Leu Asp Cys Phe Arg Thr Leu Glu Thr Ile Glu His His Lys Arg Val 
            340                 345                 350         


Ser Tyr Phe Asp Leu Phe Lys Leu Ala Arg Leu Thr Pro Gly Gln Gly 
        355                 360                 365             


Pro Ala Tyr Arg Leu Ile Lys Asp His Leu Phe Met Lys Asp Val Glu 
    370                 375                 380                 


Tyr Val Lys Leu Arg Pro Asn Lys Lys Pro Thr Lys Asp Cys Leu Gly 
385                 390                 395                 400 


Leu Trp Thr Asp Ser Arg His Gln Asn Gln Cys Val Lys Tyr Lys Asp 
                405                 410                 415     


Trp Gln Lys Leu Ser Asn Gly Lys Glu His Ser Met Asn Gly Ile Met 
            420                 425                 430         


Ala Phe Asn Gly Leu Val Asp Leu Pro His Asp Arg Phe His Lys Arg 
        435                 440                 445             


Asn Trp Asp Lys Asp Phe Ile Leu Lys Met Asp Leu Gln Thr Val His 
    450                 455                 460                 


His Pro Val Leu Lys Asp Phe Ser Ser Lys Ile His Asp Ser Leu Gln 
465                 470                 475                 480 


Asp Gly Leu Ile Lys Asn His Ala Ala Asn Ala Gly Asp Leu Ile Gly 
                485                 490                 495     


Asn Trp Val Glu Val Ala Ser Ser Lys Phe Gly Ser Phe Phe Lys Glu 
            500                 505                 510         


Ala Glu Lys Ile Ile Leu Ser Val Ile Ile Ile Ile Ile Ile Ile Leu 
        515                 520                 525             


Ile Ile Gly Met Cys Ile Lys Ile Arg Lys Arg Gln Asn Ile Gln Tyr 
    530                 535                 540                 


Ile Lys Gln Asn Ser Asp Ser Asn Pro Lys Leu Glu Gln Ala Glu Leu 
545                 550                 555                 560 


Gln Ile Phe 
            


<210>  503
<211>  573
<212>  PRT
<213>  Keuraliba ledantevirus

<400>  503

Met Glu Cys Ile Met Phe Trp Thr Ile Leu Ala Leu Ser Ile Ser Phe 
1               5                   10                  15      


Gly Phe Ser Tyr Pro Ile Glu Asp Gln Met Thr Ile Pro Leu Lys Pro 
            20                  25                  30          


Gly Ile His Arg Thr Leu Asp Gly Asp Leu Asp Tyr Asn Asp Asp Glu 
        35                  40                  45              


His Tyr His Ser Pro Pro Leu Val Leu Pro Val Pro Asn Asn Arg Ser 
    50                  55                  60                  


Trp Lys Pro Val Asn Leu Ser Thr Leu Lys Cys Pro Glu Ser Ser His 
65                  70                  75                  80  


Leu Gly Pro Asp Thr His Arg Thr Leu Glu Lys Trp Leu Ile Phe Arg 
                85                  90                  95      


Pro Lys Ser Ser Ile Leu Thr Lys Ile Glu Gly Val Leu Cys His Lys 
            100                 105                 110         


Ser Arg Trp Leu Thr Arg Cys Gln Tyr Thr Trp Tyr Phe Ser Lys Thr 
        115                 120                 125             


Ile Ser Arg Lys Ile Glu Pro Ile Pro Pro Thr Phe Gln Glu Cys Gln 
    130                 135                 140                 


Glu Ala Ile Lys Leu Lys Glu Glu Gly Ile Leu Glu Asn Leu Gly Phe 
145                 150                 155                 160 


Pro Pro Pro Asn Cys Tyr Trp Ala Arg Thr Asn Asp Glu Glu Asn Ile 
                165                 170                 175     


Leu Ile Glu Ile Ser Glu His Pro Met Thr Tyr Asp Pro Tyr Leu Asp 
            180                 185                 190         


Gly Val Ile Asp Ser Ile Leu Val Gly Gly Lys Cys Ser Gln Lys Glu 
        195                 200                 205             


Cys Glu Thr Val His Asp Ser Thr Ile Trp Ile Glu Thr Gln Arg Asp 
    210                 215                 220                 


Thr Arg Pro Ser Gln Cys Asp Met Gly Thr Glu Glu Gln Leu Glu Leu 
225                 230                 235                 240 


Val Ser Gly Leu Lys Gln Ile Asp Gly Asn Lys Gln Lys Tyr Gln His 
                245                 250                 255     


Ser Val Phe Val Val Gly Thr Asn Tyr Pro Phe Met Asp Ala Lys Gly 
            260                 265                 270         


Ala Cys Lys Leu Arg Phe Cys Gly Lys Ser Gly Met Leu Leu Ser Asn 
        275                 280                 285             


Gly Leu Trp Phe Asn Ile Ala His Thr Ile Leu Pro Lys Pro Glu Ala 
    290                 295                 300                 


Asn Ser Asn Phe Trp Ser Ala Leu Pro Asp Cys Ser Ser Asp Lys Gln 
305                 310                 315                 320 


Val Gly Val Leu Gly Glu Glu Tyr Glu Ile Glu Lys Leu Gln Ala Thr 
                325                 330                 335     


Met Glu Asp Ile Met Trp Asp Leu Asp Cys Phe Arg Thr Val Asp Ser 
            340                 345                 350         


Leu Ala His His Lys Lys Val Ser Met Leu Asp Leu Phe Arg Leu Ala 
        355                 360                 365             


Lys Leu Thr Pro Gly Pro Gly Pro Ala Tyr Lys Leu Ile Glu Gly Thr 
    370                 375                 380                 


Leu Met Met Lys Glu Val Gln Tyr Val Lys Ala Arg Arg Asp Thr Lys 
385                 390                 395                 400 


Glu Gln Ala Asn Pro Leu Cys Ala Ala Tyr Ile Thr Glu Ser Thr Ser 
                405                 410                 415     


Asn Gln Glu Arg Cys Ile Asp Tyr Ser Asn Tyr Asp Gln Asn Gly Thr 
            420                 425                 430         


Tyr Lys Gly Gln Val Met Asn Gly Ile Leu Val Thr Asp Gly Val Leu 
        435                 440                 445             


Ile Phe Pro His Glu Arg Phe His Leu Arg Gln Trp Asp Pro Glu Phe 
    450                 455                 460                 


Ile Ile Lys His Asp Leu Gln Gln Val His His Pro Val Ile Gly Asn 
465                 470                 475                 480 


Phe Ser Lys Lys Leu His Asp Ser Ile His Asn Ser Leu Ile Lys Asp 
                485                 490                 495     


His Ser Ala Asn Leu Gly Asp Val Met Gly Asn Trp Val Lys Val Ala 
            500                 505                 510         


Ala Ser Lys Val Ser Gly Phe Phe Lys Glu Ile Glu Lys Phe Leu Ile 
        515                 520                 525             


Gly Gly Leu Leu Leu Val Val Ile Leu Leu Met Val Gly Leu Leu Cys 
    530                 535                 540                 


Lys Cys Lys Cys Arg Arg Lys Pro Lys Ala Lys Asn Leu Lys Ala Asn 
545                 550                 555                 560 


Ser Ser Gly Asp Glu Met Ser Pro Asn Glu Ser Ile Phe 
                565                 570             


<210>  504
<211>  549
<212>  PRT
<213>  Kolente ledantevirus

<400>  504

Met Ile Leu Leu Ile Ile Leu Ser Leu Leu Ala Arg Arg Ala Ala Gly 
1               5                   10                  15      


Thr Ser Gly Gly Pro Thr Pro Ala Pro Leu Gln Asp Pro Ser Ile Val 
            20                  25                  30          


Glu Lys Ser Asp His Leu Asp Gly Thr Ile Leu Leu Pro Leu Arg Leu 
        35                  40                  45              


Ser Glu Ser Trp Lys Pro Ile Ser Val Ser Ser Leu Glu Cys Pro His 
    50                  55                  60                  


Arg Ala Lys Arg Thr Gly Arg Phe Gly Val Arg His Lys Val Phe Asn 
65                  70                  75                  80  


Leu Thr Arg Phe Asp His Phe Ser Ser Gly Leu Val Glu Gly Tyr Leu 
                85                  90                  95      


Cys His Lys Ile Arg Trp Val Thr Ser Cys Gln Lys Thr Trp Tyr Phe 
            100                 105                 110         


Ser Ala Thr Val Thr Arg Arg Val Glu Pro Leu Leu Pro Thr Glu Ala 
        115                 120                 125             


Glu Cys Arg Glu Ala Val Asn Leu Glu Gln His Gly Ile Leu Glu Ser 
    130                 135                 140                 


Gly Ser Tyr Pro Pro Glu Ser Cys Tyr Trp Asn Ser Leu Asn Glu Glu 
145                 150                 155                 160 


Ala Val Thr Glu Ile His Leu Thr Thr His Asn Val Gly Leu Asn Pro 
                165                 170                 175     


Tyr Thr Met Glu Trp Val Asp Ser Ile Phe Leu Lys Gly Ser Cys Lys 
            180                 185                 190         


Asp Gln Ile Cys Pro Thr Glu His Ser Thr Val Leu Trp Leu Lys Asp 
        195                 200                 205             


Pro Asp Gln Gln Thr His Asn Met Cys Gly Thr Glu Val Thr Glu His 
    210                 215                 220                 


Ala Glu Leu Met Lys Arg Ala Ser Ser Gly Ser Asn Ile Ser Trp Ser 
225                 230                 235                 240 


Asp Tyr Thr Leu Val Ser His His Leu Pro Ala Thr Thr Met Glu Gly 
                245                 250                 255     


Ala Cys Tyr Leu Asp Phe Cys Gly Lys Glu Gly Ile His Leu His Asn 
            260                 265                 270         


Gly Ile Trp Phe Ala Leu Pro Asp Ile Ser Lys Leu Gly Pro Glu Thr 
        275                 280                 285             


Leu Ser Arg Cys Pro Glu Asp Thr Lys Ala Gly Ser Val Ser Pro Ala 
    290                 295                 300                 


Tyr Ala Glu Asp Asp Leu Gln Phe Gln Leu Lys Asp Met Lys Arg Asp 
305                 310                 315                 320 


Ile Glu Cys Leu Asn Val Leu Glu Thr Ile Gln Ala Thr Gly Thr Ile 
                325                 330                 335     


Ser Phe Arg Ser Leu Gln Tyr Phe His Pro Arg Asp Val Gly Val His 
            340                 345                 350         


Pro Val Tyr Arg Ile Ile Asn Gly Ser Leu Glu Met Ala Thr Ala Arg 
        355                 360                 365             


Tyr Ala Ile Ala His Ile Pro Leu Glu Gly Asn Glu Ser Cys Ile Gly 
    370                 375                 380                 


Leu Val Thr Glu Asn Thr Arg Leu Lys Cys Val Gly Trp Asn Asp Trp 
385                 390                 395                 400 


Ile Pro Val Lys Glu Asn Leu Lys Gln Gly Phe Asn Gly Ile Met Ser 
                405                 410                 415     


Asp His Gly Arg Ile Ile Tyr Pro Ile Arg Tyr Leu Leu Gly Asp Glu 
            420                 425                 430         


Trp Asn Pro Glu Met His Ala Leu Gln Tyr Val Lys Phe Met Pro His 
        435                 440                 445             


Pro Leu Leu His Pro Tyr Ser His Gln Ile Lys Asp Lys Gly Arg Ser 
    450                 455                 460                 


Glu Leu Val Met Asp His Ser Gln Asn Val Gly Asp Val Ile Val Asn 
465                 470                 475                 480 


Ser Ala Gly Thr Phe Phe Ser Arg Ile Gly Ser Phe Phe Ser Gln Ala 
                485                 490                 495     


Phe Asp Gln Leu Ile His Ile Ala Val Ile Leu Gly Ile Gly Leu Ala 
            500                 505                 510         


Cys Tyr Val Ala Val Lys Met Phe Leu Lys Trp Lys Arg Asn Arg Glu 
        515                 520                 525             


Pro Phe Lys Ala Val Glu Arg Gly Gln Lys Glu Gln Glu Met Thr Glu 
    530                 535                 540                 


Leu Ala Gly Phe Gly 
545                 


<210>  505
<211>  551
<212>  PRT
<213>  Kumasi ledantevirus

<400>  505

Met Ala Gly Phe Tyr Leu Leu Ala Leu Thr Leu Val Cys Tyr Leu Thr 
1               5                   10                  15      


Leu Val Glu Ser Asp Gly Thr Pro Ala Pro Val Val Lys Asn Glu Thr 
            20                  25                  30          


Gly Asp Phe Leu Trp Gly Leu Gly Thr Glu Leu Ile Leu Pro Val Glu 
        35                  40                  45              


Val Ile Ser Lys Trp Val Glu Ile Asn Pro Glu Asp Met Arg Cys Pro 
    50                  55                  60                  


Ser Asp Pro Val Thr Asp His Val Ile Gly Ala Ile Val Gly His Thr 
65                  70                  75                  80  


Arg Phe Ser Arg Tyr Ser Gly Phe His Lys Ala Thr Gln Lys Gly Phe 
                85                  90                  95      


Leu Cys His Lys Met Arg Trp Ile Thr Ala Cys Thr Thr Thr Trp Tyr 
            100                 105                 110         


Phe Ser His Asp Val Gln Arg Arg Val Glu Ala Gln Glu Pro Gly Thr 
        115                 120                 125             


Gln Glu Cys Leu Asp Gln Val Lys Lys Arg Gly Glu Gly Thr Glu Glu 
    130                 135                 140                 


Glu Gly Ser Tyr Pro Pro Ser Gln Cys Ala Trp Asn Ser Val Asn Glu 
145                 150                 155                 160 


Glu Ala Glu Val Val Ile His Leu Thr Val His Glu Val Arg Val Asp 
                165                 170                 175     


Pro Tyr Thr Met Glu Leu Leu Asp Pro Val Phe Pro Ser Gly Arg Cys 
            180                 185                 190         


Asn Thr Thr Ala Cys Asp Thr Val His Gln Ser Val Leu Trp Ile Glu 
        195                 200                 205             


Asp Pro Ser Lys Thr Arg Pro Ser Cys Gly Asp Arg Val Val Asp Glu 
    210                 215                 220                 


Gly Asn Ile Ile Arg Ser Gly Trp Thr Asp Asn Val Pro Gly Ala Tyr 
225                 230                 235                 240 


Tyr Leu Ile Ser Gln His Leu Pro Pro Thr Lys Ile Asp Gly Ala Cys 
                245                 250                 255     


Arg Leu Ser Phe Cys Gly Glu Ser Gly Leu Leu Phe Glu Asn Gly Ile 
            260                 265                 270         


Trp Thr His Asp Ile Lys Leu Glu Thr Val Val Ala Asn Gln Thr Phe 
        275                 280                 285             


Gln Asn Cys Gln Ala Asp Arg Arg Ala Gly Ala Val Gly Pro Thr Tyr 
    290                 295                 300                 


Glu Ile Asp Lys Leu Arg Phe Asp Trp Glu Ala Ala Lys Glu Lys Ile 
305                 310                 315                 320 


Lys Cys Leu Asp Met Ile Glu Ile Ile Ser Ala Thr Gly Ala Leu Ser 
                325                 330                 335     


Phe Arg Arg Leu His His Phe Asn Pro Arg Thr Pro Gly Ile His Pro 
            340                 345                 350         


Val Tyr Arg Ile Val Asn Lys Thr Leu Gln Met Ala Lys Ala His Tyr 
        355                 360                 365             


Val Val Thr Asn Asn Pro Met Ser His Lys Gly Thr Arg Asp Cys Leu 
    370                 375                 380                 


Gly Thr Tyr Met Asp His Asp Thr Arg Lys Cys Val Ala Trp His His 
385                 390                 395                 400 


Trp Val Asp Val Gly Asn Gly Thr Glu Gln Gly Pro Asn Gly Leu Leu 
                405                 410                 415     


Val Thr Gly Asp Lys Val Ser Tyr Pro His Trp Phe Ile Arg Glu Lys 
            420                 425                 430         


Thr Trp Asp Pro Ala Leu His Ile Ile Asn Tyr Leu Gln Asn Ala Asp 
        435                 440                 445             


His Pro Ile Val Ser His Leu Gly Arg Tyr Ile Asp Asn Ala Ser Arg 
    450                 455                 460                 


Asp Ser Leu Arg Lys Asp Arg Ser Glu Asn Val Gly Asp Ala Ala Ser 
465                 470                 475                 480 


Ala Ala Val Thr Lys Leu Ala Gly Ser Ile Gly Gly Val Phe Lys Asp 
                485                 490                 495     


Val Trp His Val Ile Thr Thr Cys Val Thr Val Gly Val Ile Ile Ile 
            500                 505                 510         


Ile Ile Leu Ile Phe Arg Arg Met Ile Gly Val Phe Trp Arg Gly Arg 
        515                 520                 525             


Glu Lys His Pro Leu Pro Lys Thr Pro Asn Asn Ile Tyr Gln Glu Thr 
    530                 535                 540                 


His Glu Leu Lys Ser Phe Gly 
545                 550     


<210>  506
<211>  573
<212>  PRT
<213>  Le Dantec ledantevirus

<400>  506

Met Trp Ile Ile Thr Ala Leu Ile Cys Ser Phe Ser Ile Asn Pro Thr 
1               5                   10                  15      


Cys Leu Tyr Pro His Gly His Glu Asp Ser Pro Thr Val Arg His Gly 
            20                  25                  30          


Ile Ser Arg Val Leu Ser Gly Asp Ala Glu Arg Asn Asp Asp Glu His 
        35                  40                  45              


Tyr His Ser Pro Pro Leu Val Leu Pro Leu Gln Asn Glu Arg Thr Trp 
    50                  55                  60                  


Lys Pro Ala Asn Leu Ser Ser Leu Lys Cys Pro Glu Ala Ser His Leu 
65                  70                  75                  80  


Gly Pro Asp Glu His Arg Val Met Glu Lys Trp Leu Val His Arg Pro 
                85                  90                  95      


Lys Ser Ser Val Leu Thr Lys Val Glu Gly Ser Leu Cys His Lys Ser 
            100                 105                 110         


Arg Trp Leu Thr Arg Cys Glu Tyr Thr Trp Tyr Phe Ser Lys Thr Val 
        115                 120                 125             


Ser Arg Lys Ile Glu Pro Met Pro Pro Thr Lys Gln Glu Cys Glu Glu 
    130                 135                 140                 


Ala Ile Lys Arg Lys Glu Glu Gly Leu Leu Glu Ser Leu Gly Phe Pro 
145                 150                 155                 160 


Pro Pro Ala Cys Tyr Trp Ala Arg Thr Asn Asp Glu Glu Asn Val Gln 
                165                 170                 175     


Val Asp Val Thr Asp His Pro Met Thr Tyr Asp Pro Tyr Ser Asp Gly 
            180                 185                 190         


Val Val Asp Asn Ile Leu Val Gly Gly Lys Cys Asn Gln Arg Glu Cys 
        195                 200                 205             


Glu Thr Val His Asp Ser Thr Ile Trp Leu Glu Thr Gln Lys Glu Lys 
    210                 215                 220                 


Arg Pro Ser Gln Cys Glu Met Asp Val Glu Glu Gln Leu Glu Leu Val 
225                 230                 235                 240 


Ser Gly Ile Lys Arg Val Gly Gly Ser Lys Ser Lys Ala Gln Arg Ser 
                245                 250                 255     


Val Phe Val Val Gly Thr Asn Tyr Pro Phe Met Asp Ala Thr Gly Ala 
            260                 265                 270         


Cys Arg Leu Lys Tyr Cys Ser Lys Ser Gly Met Leu Leu Ser Asn Gly 
        275                 280                 285             


Leu Trp Phe His Ile Thr Arg Lys Ile Ser Pro Glu Ser Asn Glu Asn 
    290                 295                 300                 


Ser Lys Phe Trp Leu Thr Leu Ser Asp Cys Ser Ser Asp Lys Gln Val 
305                 310                 315                 320 


Gly Val Leu Gly Glu Glu Tyr Glu Ile Gly Lys Leu Gln Ala Thr Met 
                325                 330                 335     


Glu Asp Ile Met Trp Asp Leu Asp Cys Phe Arg Thr Leu Glu Asp Leu 
            340                 345                 350         


Ser His His Lys Lys Val Ser Met Leu Asp Leu Phe Arg Leu Ser Arg 
        355                 360                 365             


Leu Thr Pro Gly Thr Gly Pro Ala Tyr Lys Leu Val Lys Gly Asn Leu 
    370                 375                 380                 


Met Val Lys Glu Val Gln Tyr Val Lys Ala Gln Arg Asp Gln Gly Glu 
385                 390                 395                 400 


Leu Ala Asn Pro Leu Cys Val Ala Phe Met Thr Glu Ser Lys Asn Ala 
                405                 410                 415     


Asp Arg Cys Ile Arg Tyr Asp Glu Tyr Asp Lys Glu Gly Pro Tyr Lys 
            420                 425                 430         


Gly Gln Val Met Asn Gly Ile Leu Ile Asn Glu Gly Met Val Val Phe 
        435                 440                 445             


Pro His Glu Arg Phe His Leu Arg Gln Trp Asp Pro Glu Phe Ile Ile 
    450                 455                 460                 


Lys His Glu Ile Lys Gln Val His His Pro Val Leu Gly Asn Tyr Ser 
465                 470                 475                 480 


Ser Gln Ile His Asp Ser Leu His Glu Ser Leu Ile Lys Asp His Ser 
                485                 490                 495     


Ala Asn Leu Gly Asp Val Met Gly Asn Trp Val Gln Val Ala Thr Ser 
            500                 505                 510         


Lys Phe Ser Trp Phe Phe Lys Glu Ile Glu Lys Phe Ile Ile Gly Gly 
        515                 520                 525             


Ala Leu Leu Leu Ile Phe Ile Leu Ile Ala Leu Met Val Cys Arg Gly 
    530                 535                 540                 


Gly Cys Cys Lys Val Arg Arg Lys Ala Gly Gly Glu Lys Gly Gly Asp 
545                 550                 555                 560 


Ser Ser Gly Asp Glu Met Asn Val Ser Glu Ser Ile Phe 
                565                 570             


<210>  507
<211>  534
<212>  PRT
<213>  Mount Elgon bat ledantevirus

<400>  507

Met Lys Phe Leu Ile Val Ser Ile Leu Tyr Ile Leu Lys Ile Ser Thr 
1               5                   10                  15      


Asn Ala Ser Lys Glu Arg Lys Leu Ile Leu Pro Leu Asp His His Leu 
            20                  25                  30          


Asp Trp Lys Pro Ala His Phe Asp Lys Leu Thr Cys Pro Lys Pro Glu 
        35                  40                  45              


Leu Asp Trp Ser Glu Glu Tyr Lys Pro Ile Asn Val Ile Ser Val Leu 
    50                  55                  60                  


Arg Pro Pro Asn His Lys Ile Gly Gly Val Ser Gly Tyr Leu Cys His 
65                  70                  75                  80  


Lys Val Glu Trp Ile Thr Arg Cys Asp Tyr Lys Trp Tyr Leu Ser Lys 
                85                  90                  95      


Thr Val Ser Arg Arg Ile Lys Glu Glu Thr Pro Thr Glu Ala Glu Cys 
            100                 105                 110         


Arg Asp Ala Val Ile Leu His Lys Asn Gly Arg Glu Thr Ser Gly Ser 
        115                 120                 125             


Phe Pro Pro Glu Glu Cys Tyr Trp Asn Ser Val Asn Asp Glu Ser Asp 
    130                 135                 140                 


Ile Lys Val Ser Val Thr Ala His Asp Ile Gly Tyr Asp Pro Tyr Leu 
145                 150                 155                 160 


Asn Val Gly Val Asp Ser Leu Leu Val Gly Gly Tyr Cys Asn Asn Ser 
                165                 170                 175     


Ile Cys Leu Thr Thr His Ser Ser Val Ile Trp Ile Arg Asp Gln Val 
            180                 185                 190         


Ser Lys Pro Cys Glu Gly Met Arg Leu Glu Thr Met Thr Val Tyr Thr 
        195                 200                 205             


Ser Leu Tyr Gly Tyr Thr Asn Asp Lys Trp Val Gly Thr Pro Ser Met 
    210                 215                 220                 


Lys Met Ser Ser Leu Asn Asp Ala Cys Arg Leu Ser Phe Cys Gly Val 
225                 230                 235                 240 


Gln Gly Thr Leu Leu Thr Asn Gly Leu Trp Phe His His Asn Val Arg 
                245                 250                 255     


Glu Gly Pro Gly Ser Gln Ile Gln Ile Thr Arg Asn Cys Pro Pro Asn 
            260                 265                 270         


Ser Glu Val Gly Val Val Gln Pro Asp Phe Glu Ile Lys Leu Met Asp 
        275                 280                 285             


Tyr Lys Leu Ala Asp Leu Gln Arg Glu Met Phe Cys Leu Gln Thr Leu 
    290                 295                 300                 


Asp Arg Ile Arg Leu Gln Gln Val Val Thr Leu Asn Asp Leu Gln Tyr 
305                 310                 315                 320 


Leu Arg Pro His Arg Ala Gly Ala Gly Pro Val Phe Arg Ile Arg Asn 
                325                 330                 335     


Asn Thr Leu Glu Thr Thr His Gly Thr Tyr Ile Glu Ala Ser Met Val 
            340                 345                 350         


Gly Thr Thr Gln Val Asn Arg Asn Cys Leu Ala Thr Tyr Leu Gly Glu 
        355                 360                 365             


Asp Lys Lys Pro Lys Cys Ile Gly Trp Lys Ser Trp His Lys Met Asn 
    370                 375                 380                 


Asn His Lys Tyr Gln Gly Leu Asn Gly Val Leu Glu Ile Asn Gly Leu 
385                 390                 395                 400 


Ile Lys Phe Pro Glu Asp Gln Leu Leu Asp Ala Glu Trp Glu Ala Asp 
                405                 410                 415     


Met Phe Glu Tyr Phe Lys Leu Asp Lys Ile His His Pro Phe Leu Ser 
            420                 425                 430         


Asn Ile Ser Ser Ile Ile His Asp Asp Thr Asp Glu Ser Leu Ile His 
        435                 440                 445             


Asp Lys Thr Val Asn Pro Gly Asp Ala Ile Asn Asn Trp Val Glu Val 
    450                 455                 460                 


Ala Glu Asn Arg Val Ser Thr Phe Phe Lys Thr Thr Gly Gly Glu Ile 
465                 470                 475                 480 


Ile Lys Ile Val Tyr Ile Ile Thr Leu Ile Gly Ile Ile Tyr Leu Leu 
                485                 490                 495     


Tyr Lys Ile Ile Thr Met Cys Cys Lys Met Lys Arg Thr Gly Lys Lys 
            500                 505                 510         


Asn Arg Arg Leu Thr Ser Asp Leu Ile Asp Leu Asp Leu Lys Pro Met 
        515                 520                 525             


Asn Ser Ser Val Phe Gly 
    530                 


<210>  508
<211>  541
<212>  PRT
<213>  Nkolbisson ledantevirus

<400>  508

Met Gln Leu Ser Leu Leu Met Val Met Ala Ser Leu Ala Gln Ser Val 
1               5                   10                  15      


Thr Gly Arg Ala Ala Gly Arg Glu Leu His Asp Val Ile Gly Phe Val 
            20                  25                  30          


Pro Asp Thr Asp Thr Leu Gln Trp Lys Pro Ala Asn Leu Asp Thr Leu 
        35                  40                  45              


Arg Cys Pro Glu Ala Ala Asp Pro Gly Pro Asp Asp Gly Ala Val Val 
    50                  55                  60                  


Glu Lys Trp Val Ile Ser Arg Pro Arg Val Asn Thr Phe Leu Gly Ile 
65                  70                  75                  80  


Lys Gly Tyr Leu Cys His Tyr Ala Lys Trp Val Thr Arg Cys Glu Tyr 
                85                  90                  95      


Thr Trp Tyr Leu Ser Lys Thr Ile Ser Arg Ser Ile Gln Pro Leu Asp 
            100                 105                 110         


Val Thr Glu Ser Gly Cys Gln Asp Ala Phe Lys Glu Tyr Asp Ala Gly 
        115                 120                 125             


Arg Leu Val Pro Gly Ser Phe Pro Pro Glu Ala Cys Tyr Trp Ala Ser 
    130                 135                 140                 


Thr Asn Asp Glu Thr Val His Ala Tyr Thr Ile Thr Pro His Glu Val 
145                 150                 155                 160 


Ile Tyr Asp Pro Tyr Ser Asn Ala Lys Leu Asp His Ile Phe Leu His 
                165                 170                 175     


Gly Ser Cys Asn Lys Asp Phe Cys Glu Thr Ser His Asp Ser Thr Met 
            180                 185                 190         


Trp Ile Ala Lys Arg Lys Gly Glu Gly Ser Val Cys Gln Phe Val Gly 
        195                 200                 205             


Arg Glu Asp Val Glu Ile Ile Glu Gly Ala Lys Phe Ser Leu Arg Lys 
    210                 215                 220                 


Phe Gln Thr Lys Val Trp Leu Arg Gly Pro Ser Leu His Asn Ile Pro 
225                 230                 235                 240 


Leu Asp Lys Leu Cys Lys Ile Asp Phe Cys Gly Lys Thr Gly Tyr Arg 
                245                 250                 255     


Asn Gln Gln Gly Ile Trp Phe Ser Ile Asp Arg Val Ser Trp Ser Lys 
            260                 265                 270         


Asn His Ser Leu Pro Ile Arg Gln Lys Ala Val Gly Cys Lys Pro Gly 
        275                 280                 285             


Glu Asn Val Ala Val Val Asp Thr Asn Leu Pro Asp Ser Asp Leu Glu 
    290                 295                 300                 


Ala Thr Ile Glu Glu Met Met Trp Asp Met Asn Cys Leu Asn Ala Leu 
305                 310                 315                 320 


Glu Thr Ile Gln His His Lys Lys Val Ser Leu His Asp Leu Tyr Gln 
                325                 330                 335     


Ile Ala Pro Gln Lys Ser Gly Pro Gly Leu Ala Tyr Arg Leu Asn Asp 
            340                 345                 350         


Gly His Leu Glu Val Ala Gln Ala His Tyr Trp Ser Val Gln His Pro 
        355                 360                 365             


Lys Arg Gly Lys Leu Ser Arg Thr Cys Leu Gly Ala Arg Gln Ala Asp 
    370                 375                 380                 


Glu Thr Ser Ser Cys Val Lys Trp Asn Lys Trp Thr His Val Ala Asn 
385                 390                 395                 400 


Asn Thr Tyr His Ala Val Asn Gly Ile Thr Glu Val Asp Gly Gln Ile 
                405                 410                 415     


Leu Phe Pro Lys Arg Arg Val Leu His Arg Lys Tyr Asp Pro Glu Tyr 
            420                 425                 430         


Ala Thr Arg Gln Ser Leu Arg Phe Ile Lys His Pro Val Ile Asp Lys 
        435                 440                 445             


Phe Glu Asp Lys Ala Thr Glu Asn Ile Glu His Lys Asp Ile Ile Ser 
    450                 455                 460                 


Lys Asp Val Asn Ala Gly Asp Leu Val Gly Asn Trp Val Val Val Ala 
465                 470                 475                 480 


Glu Gly Lys Leu Ser Glu Trp Phe Gly Gly Leu Gly Lys Ser Ile Ile 
                485                 490                 495     


Ser Val Val Ser Leu Ile Val Gly Leu Leu Val Leu Tyr Val Ile Val 
            500                 505                 510         


Lys Leu Cys Leu Tyr Phe Arg Pro Lys Ala Lys Glu Lys Ile Gly Asp 
        515                 520                 525             


Met Glu Met Lys Leu Lys Lys Arg Ser Glu Ser Phe Gly 
    530                 535                 540     


<210>  509
<211>  551
<212>  PRT
<213>  Oita ledantevirus

<400>  509

Met Asp Ile Val Arg Phe Phe Phe Phe Val Gly Ala Thr Ala Asn Ala 
1               5                   10                  15      


Lys Val Glu Asp Thr Thr Arg Ala Pro Leu His Glu Pro His Glu Leu 
            20                  25                  30          


Gly Met Met Leu Ser Asp Ile Pro Thr Val Ile Leu Pro Val Ser Val 
        35                  40                  45              


Gly Glu Tyr Trp Arg Glu Ala Ser Leu Lys Glu Leu Arg Cys Pro Leu 
    50                  55                  60                  


Ser Asn Leu Asp Glu Gly Pro Asp Gly Arg Thr Val Ala Ala Phe Asn 
65                  70                  75                  80  


Met Thr Arg Tyr Asp His Phe Asn Pro Ala Leu Ala Asn Gly Tyr Leu 
                85                  90                  95      


Cys His Lys Thr Lys Trp Ile Thr Arg Cys Glu Tyr Thr Trp Tyr Phe 
            100                 105                 110         


Ser Lys Thr Val Thr Arg Arg Ile Val Pro Val Leu Pro Ser His His 
        115                 120                 125             


Glu Cys His Glu Glu Arg Gln Arg Glu Ile Ser Gly Ile Pro His Glu 
    130                 135                 140                 


Gly Ser Tyr Pro Pro Glu Glu Cys Tyr Trp Asn Ser Val Asn Glu Glu 
145                 150                 155                 160 


Val Glu Glu Thr Ile Leu Leu Thr Glu His Ser Ala Gly Tyr Asp Pro 
                165                 170                 175     


Tyr Thr Glu Glu Phe Val Asp Glu Ile Phe Leu Lys Gly Arg Cys His 
            180                 185                 190         


Glu Glu Asp Cys Leu Thr Asp His Ser Thr Val Arg Trp Ile His Ser 
        195                 200                 205             


Glu Met Lys Gly Asn Lys Pro Lys Cys Gly Glu Lys Leu Val Glu Glu 
    210                 215                 220                 


Ala Glu Leu Ile Ser Leu Asn Pro Asn Arg Asp Asp Gln Asp Phe Ser 
225                 230                 235                 240 


Lys Leu Tyr Ile Tyr Ser His His Ile Pro Lys Ser Pro Leu Lys Asn 
                245                 250                 255     


Ser Cys Leu Leu Asn Phe Cys Gly Glu Glu Gly Ile Gln Leu Glu Asn 
            260                 265                 270         


Gly Phe Trp Phe Arg Thr Pro Asp Trp Lys Lys Gly Lys Gly Ile Ser 
        275                 280                 285             


Ile Pro Tyr Cys Ser Glu Gly Thr Thr Ala Lys Ala Leu Gly Asp Gly 
    290                 295                 300                 


Phe Thr Arg Ala Tyr Ile Arg Phe Glu Leu Asp Glu Leu Arg Asp Asp 
305                 310                 315                 320 


Met Ala Cys Leu Asp Ala Leu Glu Ser Ile Gln Val Thr Gly Ala Ile 
                325                 330                 335     


Ser Tyr Arg Lys Leu His Tyr Phe His Pro Arg Lys Ser Gly Ile His 
            340                 345                 350         


Pro Ile Tyr Arg Met Arg Asn Gly Thr Leu Glu Ser Asn Thr Ala Lys 
        355                 360                 365             


Tyr Val Thr Ala Tyr Ala Ile Gly Asn Glu Lys Gly Cys Leu Gly Met 
    370                 375                 380                 


Val Lys Asn Gln Ser Asp Met Ile Cys Ile Gln Trp Asn Asp Trp Ile 
385                 390                 395                 400 


Glu Val Glu Lys Asp Leu Leu Gln Gly Phe Asn Gly Leu Met Arg Asp 
                405                 410                 415     


Lys Gly Arg Leu Met Leu Pro Trp Lys Tyr Ala Ser Asp Glu Arg Trp 
            420                 425                 430         


Asn Pro Glu Ile His Lys Val Gln Phe Leu Thr Gln Ala Gln His Pro 
        435                 440                 445             


Phe Tyr Ser His Ile Ser His Met Ile Gln Asp Asp Ile Ile Asp Glu 
    450                 455                 460                 


Ile Arg Lys Asp Lys Ser Lys Asn Val Gly Asp Ser Val Val Lys Ala 
465                 470                 475                 480 


Ala Glu Ser Leu Trp Glu Arg Phe Ser Asn Phe Phe His Lys Val Lys 
                485                 490                 495     


Glu Val Ala Phe Gly Ala Gly Ile Leu Ile Thr Thr Leu Val Leu Val 
            500                 505                 510         


Leu Leu Ile Lys Lys Cys Ile Thr Leu Arg Arg Val Lys Ser Thr Lys 
        515                 520                 525             


Arg Lys Lys Lys Ala Gly Arg Pro Met Val Glu Glu Leu Glu Met Thr 
    530                 535                 540                 


Glu Ser Asp Ala Ser Phe Gly 
545                 550     


<210>  510
<211>  568
<212>  PRT
<213>  Vaprio ledantevirus

<400>  510

Met Cys Ser Leu Arg Ser Lys Ile Ala Ala Ile Ser Val Leu Ile Gly 
1               5                   10                  15      


Leu His Ala Val Leu Gly Glu Pro Arg Asn Phe Thr Gly Gly Arg Ser 
            20                  25                  30          


Ile Val Leu Glu Gly Thr Arg Lys Pro Asn Tyr Asp Glu His Tyr His 
        35                  40                  45              


Ser Pro Pro Leu Ile Leu Pro Leu Gln Asn Asp Arg Asp Trp Lys Pro 
    50                  55                  60                  


Ala Asn Leu Ser Ser Ile Arg Cys Pro Asp Pro Ala His Leu Gly Pro 
65                  70                  75                  80  


Asp Glu His Arg Thr Met Glu Thr Trp Ile Val Ala Arg Pro Arg Glu 
                85                  90                  95      


Thr Ile Lys Thr Gln Ile Ser Gly Val Leu Cys His Lys Ala Arg Trp 
            100                 105                 110         


Val Thr Arg Cys Glu Tyr Thr Trp Tyr Phe Ser Lys Thr Val Ser Arg 
        115                 120                 125             


Lys Ile Glu Pro Leu Pro Pro Lys Glu Ser Asp Cys Lys Glu Ala Ile 
    130                 135                 140                 


Lys Lys Lys Glu Glu Gly Leu Leu Glu Ser Lys Gly Phe Pro Pro Ala 
145                 150                 155                 160 


Ala Cys Tyr Trp Ala Ser Thr Asn Asp Glu Ala Tyr Glu Gln Val Glu 
                165                 170                 175     


Ile Thr Asp His Pro Ala Thr Tyr Asp Pro Tyr Val Asp Gly Val Leu 
            180                 185                 190         


Asp Ser Ile Phe Val Gly Gly Arg Cys Lys Ser Lys Ile Cys Glu Thr 
        195                 200                 205             


Val His Asp Ser Thr Leu Trp Ile Glu Ser Thr Arg Ala Thr Arg Pro 
    210                 215                 220                 


Ala Ala Cys Thr Met His Glu Glu Glu Gln Leu Glu Leu Ile Ser Gly 
225                 230                 235                 240 


Ile Lys Glu Ala Gly Gly Ser Lys Thr Trp Met Gln Tyr Ser Val Phe 
                245                 250                 255     


Val Val Gly Thr Asn Tyr Pro Phe Met Asp Ala Lys Gly Ser Cys Lys 
            260                 265                 270         


Leu Lys Tyr Cys Gly Lys Asn Gly Leu Leu Leu Ser Asn Gly Leu Trp 
        275                 280                 285             


Phe His Ile Leu His Thr Val Arg Thr Glu Gly Glu Ala Val Ala Gly 
    290                 295                 300                 


Phe Trp Asp Ser Leu Pro Asp Cys Thr Pro Asn Arg Glu Val Gly Val 
305                 310                 315                 320 


Leu Gly Glu Glu Tyr Glu Ile Glu Val Leu Glu Ala Thr Ile Glu Asp 
                325                 330                 335     


Ile Met Trp Asp Leu Asp Cys Phe Arg Thr Val Glu Asp Leu Gln His 
            340                 345                 350         


His Lys Arg Val Ser Leu Leu Asp Leu Phe Arg Leu Ser Arg Leu Thr 
        355                 360                 365             


Pro Gly Ile Gly Pro Ala Tyr Thr Ile Lys Gly Lys Thr Leu Phe Thr 
    370                 375                 380                 


Lys Asp Val Glu Tyr Val Lys Ala Asn Lys Ile Lys Asp Ala Asp Ser 
385                 390                 395                 400 


Thr Pro Lys Cys Ala Ala His Phe Leu Lys Thr Asn Ala Gly Gln Arg 
                405                 410                 415     


Cys Val Glu Tyr Thr Glu Tyr Asp Lys Asn Gly Pro Arg Lys Gly His 
            420                 425                 430         


Val Met Asn Gly Ile Met Ile Val Asp Gly Lys Val Lys Phe Pro His 
        435                 440                 445             


Asp Arg Phe His Leu Arg Asn Trp His Pro Asp Phe Ile Leu Lys His 
    450                 455                 460                 


Glu Ile Ser Met Val His His Pro Val Ile Gly Asn Ile Ser Ser Lys 
465                 470                 475                 480 


Ile His Asp Ser Ile Asp Glu Asn Leu Val Lys Glu Lys Asp Ala Asn 
                485                 490                 495     


Ala Gly Asp Met Ile Gly Gly Trp Val Lys Ile Ala Ser Ser Lys Ile 
            500                 505                 510         


Ser Trp Phe Phe Lys Glu Ile Glu Lys Phe Val Leu Ala Phe Val Ile 
        515                 520                 525             


Leu Ile Ile Phe Leu Leu Leu Ile Ser Val Leu Phe Lys Ile Arg Lys 
    530                 535                 540                 


Arg Asn Lys Thr Asp Ser Lys Asn Glu Lys Arg Ala Thr Glu Arg Leu 
545                 550                 555                 560 


Lys Lys Ile Glu Glu Ser Val Phe 
                565             


<210>  511
<211>  546
<212>  PRT
<213>  Wuhan ledantevirus

<400>  511

Met Ile Ala Phe Leu Ile Leu Ile Ala Cys Ala Asn Gly Tyr Ile Asn 
1               5                   10                  15      


Asp Asn Asp Thr Glu Tyr Val Trp Arg Ala Arg Pro Leu Gly Ser Val 
            20                  25                  30          


Ala Asp Lys Gly Val Leu Tyr Val Pro Leu Asp His Ser Lys Asn Trp 
        35                  40                  45              


Arg Pro Ala Lys Tyr Gln Asp Leu Lys Cys Pro Lys Pro Gln Gly Asp 
    50                  55                  60                  


Trp Gln Leu Lys Phe Ile Ile His Thr Arg Trp Val Thr Trp Arg Pro 
65                  70                  75                  80  


Asp Asp Ile Ser Leu Asp His Ile Pro Gly Phe Leu Cys His Lys Ala 
                85                  90                  95      


Glu Trp Ile Thr Arg Cys Glu Tyr Thr Trp Tyr Leu Ser Lys Thr Val 
            100                 105                 110         


Ser Arg Lys Leu Lys Glu Glu Thr Pro Ser Glu Ser Glu Cys Gln Asp 
        115                 120                 125             


Ala Val Arg Leu Tyr Glu Ala Gly Lys Gln Glu Ala Gly Ser Phe Pro 
    130                 135                 140                 


Pro Glu Glu Cys Tyr Trp Asn Ser Val Asn Asp Glu Ser Val Val Lys 
145                 150                 155                 160 


Thr Ile Val Val Glu His Ser Ile Ala Tyr Asp Pro Tyr Lys Asp Cys 
                165                 170                 175     


Gly Val Asp Glu Ala Leu Val Gly Gly Ser Cys Lys Lys Lys Phe Cys 
            180                 185                 190         


Asp Thr Lys Tyr Ser Ser Val Lys Trp Val Gln Asp Val Asp His Glu 
        195                 200                 205             


Ser Gln Arg Cys His Asn Ile Ile Gln Glu Gln Leu Glu Ile Leu Lys 
    210                 215                 220                 


Arg Asn Asp Asn Lys Glu Gln Asp Lys Ser Trp Val Arg Ser Lys Ser 
225                 230                 235                 240 


Phe Pro Ile Thr Glu Met Asp Asp Ala Cys Lys Met Ser Phe Cys Gly 
                245                 250                 255     


Leu Asp Gly Ile Arg Leu Lys Asn Gly Ile Trp Phe Gly Phe Gln Lys 
            260                 265                 270         


Ser Arg Thr Asp His Ser Asp Met Gly Asp Ile Pro Gln Cys Val Ser 
        275                 280                 285             


Gly Thr Glu Ile Gly Ile Pro Asp Lys Asn Tyr Lys Glu Lys Glu Phe 
    290                 295                 300                 


Glu Tyr Glu Leu Glu Asp Leu Gln Arg Glu Ile Leu Cys Leu Asn Val 
305                 310                 315                 320 


Leu Asp Lys Leu Gln Leu Asn Gln Val Ile Ser Leu Tyr Asp Leu Gln 
                325                 330                 335     


Tyr Leu Arg Gln Asp Ala Pro Gly Tyr Gly Asn Ile Phe Arg Val Asn 
            340                 345                 350         


Asn Gly Thr Leu Glu Val Thr Thr Gly Lys Tyr Ile Lys Val Tyr His 
        355                 360                 365             


Ala Lys Asn Asp Leu Ser Pro Asp Cys Ile Gly Thr Tyr Lys Asp His 
    370                 375                 380                 


Ser Gly Asp Asp Val Cys Val Asp Trp Asp Glu Trp Leu Pro Ile Glu 
385                 390                 395                 400 


Lys Asp Lys Asp Gln Gly Phe Asn Gly Ile Ile Arg Ile Lys Asn Lys 
                405                 410                 415     


Ile Ile Phe Pro Asp Asp Gln Leu Arg Ala Ser Glu Trp Arg Glu Glu 
            420                 425                 430         


Leu Phe Asp Tyr Phe Lys Val Asp Lys Ile His His Pro Phe Leu Asn 
        435                 440                 445             


Asn Val Thr Asp Val Ile His Asp Asp Thr Asp Asp Glu Asn Leu Ile 
    450                 455                 460                 


His Asp Lys Thr Val Asn Pro Gly Asp Ala Ile Asn Asn Trp Val Lys 
465                 470                 475                 480 


Val Ala Glu Asn Lys Val Val Asn Phe Phe Lys Glu Leu Gly Ile Gly 
                485                 490                 495     


Ile Ile Ile Ile Val Trp Ile Ile Ala Gly Ile Ile Phe Leu Phe Ile 
            500                 505                 510         


Leu Phe Lys Leu Ile Arg Phe Cys Ile Lys Leu Arg Tyr Lys Lys Val 
        515                 520                 525             


Asn Thr Gly Asp Lys Glu Ile Glu Met Arg His Tyr Asp Ser Pro Ile 
    530                 535                 540                 


Phe Gly 
545     


<210>  512
<211>  535
<212>  PRT
<213>  Yongjia ledantevirus

<400>  512

Met Thr Gly Leu Leu Met Leu Ala Leu Ala Leu Thr Leu Cys His Gly 
1               5                   10                  15      


Leu Asn Ile Tyr Gln Glu Gly Gly Val Leu Leu Pro Leu Ser Glu Asp 
            20                  25                  30          


Ile Thr Trp Arg His Val Lys Leu Asp Gln Val Gln Cys Pro Phe Lys 
        35                  40                  45              


Gly Asp Gln Gly Pro Asp Glu Gly Gln Ile Leu Glu Lys Trp Thr Val 
    50                  55                  60                  


Gly Arg Pro Arg Gln Arg His Asp Leu Lys Leu Asn Gly Tyr Leu Cys 
65                  70                  75                  80  


His Lys Ala Arg Trp Thr Thr Arg Cys Val Tyr Thr Trp Tyr Phe Ser 
                85                  90                  95      


Lys Thr Val Ser Arg Gln Ile Glu Asn Leu Lys Val Ser Asp Gln Asp 
            100                 105                 110         


Cys Ala Ser Ala Leu Lys Gln Gln Gln Glu Gly Gln Leu Pro Thr Gly 
        115                 120                 125             


Ser Phe Pro Pro Glu Ser Cys Tyr Trp Ala Thr Thr Asn Asp Glu Thr 
    130                 135                 140                 


Val Glu Ala Val Thr Val Thr Pro His Pro Val His Tyr Asp Pro Tyr 
145                 150                 155                 160 


Thr Asn Glu Ala Val Asp Thr Leu Phe Pro Asn Gly Arg Cys Gly Asn 
                165                 170                 175     


Leu Leu Cys Pro Thr Val Tyr Asp Ser Thr Val Trp Met Gln Gly Gln 
            180                 185                 190         


Asn Asp Leu Leu Glu Ile Cys Ser Phe Lys Glu Asp Glu Pro Leu Glu 
        195                 200                 205             


Val Val Glu Gly Val Lys Ile Ser Gly Gly Met Gly Ile Asn Val Asp 
    210                 215                 220                 


Leu Trp Ile Thr Gly Pro His Leu Pro His Glu Lys Leu Leu Gly Ile 
225                 230                 235                 240 


Cys His Lys Asn Phe Cys Gly Lys Ser Gly Leu Leu Thr Leu Ser Gly 
                245                 250                 255     


Thr Trp Phe Tyr Leu Gln Gln Ile Val Tyr Lys Lys Asn Asn Ser Leu 
            260                 265                 270         


Asp Val Leu Lys Arg Val Pro Glu Cys Asn Ser Thr Arg Leu Val Gly 
        275                 280                 285             


Val Leu Asp Glu Met Glu Pro Tyr Leu Gln Met Arg Ala Thr Leu Glu 
    290                 295                 300                 


Glu Ile Thr Trp Asp Met Asn Cys Leu Ala Thr Val Asp Ser Ile His 
305                 310                 315                 320 


His His Asn Arg Ala Ser Pro His Asp Leu Phe Gln Ile Ser Pro Thr 
                325                 330                 335     


His Pro Gly Thr Gly Pro Ile Tyr Arg Ile Thr Lys Gly Gly Leu Glu 
            340                 345                 350         


Met Gly Thr Ala Glu Tyr Val Val Ala Glu Pro Glu Arg Arg Pro Thr 
        355                 360                 365             


Arg Gln Cys Leu Gly Arg Tyr Ser Thr Asn Thr Gly Lys Gln Cys Val 
    370                 375                 380                 


Gly Trp Lys Gly Trp Thr Gln Met Glu Asn Ser Thr Phe His Ala Phe 
385                 390                 395                 400 


Asn Gly Ile Thr Glu Arg Asn Gly Gln Ile Lys Leu Pro Lys Asp Arg 
                405                 410                 415     


Met Ala Thr Arg Asp Trp Gly Glu Glu Tyr Ile Lys Lys His Pro Leu 
            420                 425                 430         


Ser Phe Tyr His His Pro Ser Leu Gly Asn Leu Thr Arg Lys Ile Thr 
        435                 440                 445             


Glu Asn Ile Leu His Lys Val Ile Lys Ser His Asn Val Asn Ala Gly 
    450                 455                 460                 


Asp Leu Ile Gly Asn Trp Val Thr Val Val Glu Asp Lys Val Ser Ser 
465                 470                 475                 480 


Phe Phe Ser His Leu Gly Gly Ser Val Val Gly Leu Leu Ser Val Ile 
                485                 490                 495     


Leu Val Val Gly Val Ile Tyr Met Leu Ile Gln Ile Ile His Lys Ile 
            500                 505                 510         


Arg Thr Pro Arg Pro Gln Phe His Ser Arg Asp Met Glu Leu Gln Lys 
        515                 520                 525             


Pro Thr His Ser Val Phe Gly 
    530                 535 


<210>  513
<211>  524
<212>  PRT
<213>  Lonestar lostrhavirus

<400>  513

Met Ile Arg Ile Gln Pro Gly Leu Ala Ile Leu Ile Val Phe Thr Ile 
1               5                   10                  15      


Ser Pro Ile Leu Ser Ser Arg His Ser Val Ile Met Phe Pro His Val 
            20                  25                  30          


Val Thr Pro Trp Ile Arg Ala Lys Thr Ser Asp Leu Ser Cys Pro Pro 
        35                  40                  45              


Ser Ser Pro Leu Glu Thr Pro Asn Ala Leu Pro Ile Thr Glu Ile Asp 
    50                  55                  60                  


Val Phe Ile Gln Lys Asp His Lys Glu Leu Glu Leu Ile Pro Gly Leu 
65                  70                  75                  80  


Leu Cys Tyr Gly Leu Lys Tyr Val Thr His Cys Ser Glu Gly Phe Phe 
                85                  90                  95      


Gly Gln Lys Thr Ile Ser Lys Arg Ile Asp Lys Ile Ala Pro Thr Leu 
            100                 105                 110         


Thr Asp Cys Arg Lys Ser Tyr Glu Ile Tyr Glu Lys Gly Glu Gln Ile 
        115                 120                 125             


Asp Pro Tyr Phe Pro Ala Ser Lys Cys Thr Trp Met Ala Glu Asp Glu 
    130                 135                 140                 


Asp Ser Lys Asn Phe Tyr Leu Leu Thr Pro His Ser Val Lys Tyr Asp 
145                 150                 155                 160 


Pro Tyr Thr Thr Gly Ala Thr Asp Pro Leu Phe Leu Arg Asp His Cys 
                165                 170                 175     


Lys Glu Thr Thr Cys Glu Thr Val His Ala Asn Thr Ile Trp Met Thr 
            180                 185                 190         


Thr Lys Ser Ile Asn Arg Cys Ser Pro Phe Gln Arg His Val Gly Thr 
        195                 200                 205             


Leu Tyr His Asp Pro Arg Lys Asn Val Thr His Ile Gln Tyr Lys Gly 
    210                 215                 220                 


Thr His Thr Tyr Ser Leu Asn Gly Ser Cys Leu Met Asn Tyr Cys Asp 
225                 230                 235                 240 


Lys Phe Gly Val Arg Leu Ser Asn Gly Leu Phe Leu Gly Gly Pro Leu 
                245                 250                 255     


Ala Thr Lys Ile Pro Asn Gly Pro Lys Cys Pro Gln Gly Thr Thr Val 
            260                 265                 270         


Lys Phe Val Pro Ile Glu Asp Glu Ile Glu Thr Leu Glu Glu Glu Ile 
        275                 280                 285             


Gln Glu Asp Arg Asp Arg Glu Thr Cys Leu Val Gln Leu Met Thr Val 
    290                 295                 300                 


Arg Met Ser Asn Phe Ser Thr Phe Phe Ser Leu Ser Tyr Met Asp Pro 
305                 310                 315                 320 


Lys Phe Glu Ser Arg Gly Lys Val Phe Arg Ile His Gln Asn His Leu 
                325                 330                 335     


Glu Met Ala His Ala Asp Trp Ile Pro Val Thr Asn Val Thr Asn His 
            340                 345                 350         


Lys Gln Asn Leu Ile Gly Ile Ser Asn Arg Gly Lys Glu Leu Tyr Phe 
        355                 360                 365             


Thr Asp Trp Val Pro Ser Gly Arg His Asn Leu Ser Ser Gly Trp Asn 
    370                 375                 380                 


Gly Val His Lys Thr Ser Lys Gly Lys Ile Ile Ile Pro Arg Leu Ser 
385                 390                 395                 400 


Leu Leu Lys Gln Glu Tyr Glu Glu Thr Leu Leu Val Glu His Asn Leu 
                405                 410                 415     


Arg Glu Ile Thr Pro Val His Ile His His Phe Asp Lys Glu Gly Leu 
            420                 425                 430         


Asn Asp Thr Val Val Thr Leu Thr Ser His Glu Leu Val Asp Val Gly 
        435                 440                 445             


Ala Trp Ile Gly Ser Val Trp Ser Thr Leu Trp Gly Lys Ile Thr Thr 
    450                 455                 460                 


Ile Val Thr Val Ile Ile Ala Leu Ile Ile Leu Tyr Phe Ile Val Arg 
465                 470                 475                 480 


Cys Cys Val Pro Ile Leu Ser Arg Cys Cys Lys Lys Lys Glu Ser Lys 
                485                 490                 495     


His Pro Glu Phe Glu Met Val Pro Leu Arg Ser Pro Ser Ser Thr Pro 
            500                 505                 510         


Ser Arg Val Thr Leu Thr Arg Pro Lys Gly Trp Gln 
        515                 520                 


<210>  514
<211>  526
<212>  PRT
<213>  Aravan lyssavirus

<400>  514

Met Pro Leu Gln Ala Ile Pro Leu Phe Ser Leu Ile Leu Pro Val Leu 
1               5                   10                  15      


Val Ala Gly Lys Phe Pro Ile Tyr Thr Ile Pro Asp Lys Ile Gly Pro 
            20                  25                  30          


Trp Ser Pro Ile Asp Ile Asn His Leu Ser Cys Pro Asn Asn Leu Val 
        35                  40                  45              


Val Glu Asp Glu Gly Cys Thr Thr Leu Thr Ala Phe Ser Tyr Met Glu 
    50                  55                  60                  


Leu Lys Val Gly Tyr Ile Thr Thr Ile Lys Val Ser Gly Phe Thr Cys 
65                  70                  75                  80  


Thr Gly Val Val Thr Glu Ala Glu Thr Tyr Thr Asn Phe Val Gly Tyr 
                85                  90                  95      


Val Thr Thr Thr Phe Arg Arg Lys His Phe Arg Pro Thr Ala Ser Ala 
            100                 105                 110         


Cys Arg Glu Ala Tyr Asn Trp Lys Ala Thr Gly Asp Pro Arg Tyr Glu 
        115                 120                 125             


Glu Ser Leu His Asn Pro Tyr Pro Asp Ser His Trp Leu Arg Thr Val 
    130                 135                 140                 


Lys Thr Thr Lys Glu Ser Leu Leu Ile Ile Ser Pro Ser Val Ala Asp 
145                 150                 155                 160 


Met Asp Ala Tyr Asp Lys Ala Leu Tyr Ser Lys Ile Phe Pro Asn Gly 
                165                 170                 175     


Lys Cys Leu Gly Val Ser Leu Ser Ser Pro Phe Cys Ser Thr Asn His 
            180                 185                 190         


Asp Tyr Thr Leu Trp Met Pro Glu Asn Pro Lys Pro Gly Val Ser Cys 
        195                 200                 205             


Asp Ile Phe Thr Thr Ser Lys Gly Lys Lys Ala Thr Lys Asp Gly Lys 
    210                 215                 220                 


Leu Cys Gly Phe Val Asp Glu Arg Gly Leu Tyr Lys Ser Leu Lys Gly 
225                 230                 235                 240 


Ala Cys Lys Leu Lys Leu Cys Gly Val Met Gly Leu Arg Leu Met Asp 
                245                 250                 255     


Gly Ser Trp Val Ser Leu Gln Lys Thr Glu Glu Ser Glu Trp Cys Ser 
            260                 265                 270         


Pro Asn Gln Leu Ile Asn Ile His Asp Phe His Ser Asp Glu Ile Glu 
        275                 280                 285             


His Met Val Val Glu Glu Leu Val Lys Lys Arg Glu Glu Cys Leu Asp 
    290                 295                 300                 


Ala Leu Glu Ser Ile Met Thr Thr Lys Ser Ile Ser Phe Arg Arg Leu 
305                 310                 315                 320 


Ser His Leu Arg Lys Leu Val Pro Gly Phe Gly Lys Ala Tyr Thr Leu 
                325                 330                 335     


Ile Asn Lys Thr Leu Met Glu Ala Asp Ala His Tyr Lys Ser Val Arg 
            340                 345                 350         


Glu Trp Thr Glu Val Ile Pro Ser Lys Gly Cys Leu Lys Ala Gly Gly 
        355                 360                 365             


Gly Cys Tyr Pro His Tyr Asn Arg Val Phe Phe Asn Gly Ile Ile Leu 
    370                 375                 380                 


Ser Pro Asp Gly His Val Leu Ile Pro Glu Met Gln Ser Ala Leu Leu 
385                 390                 395                 400 


Gln Gln His Ile Glu Leu Leu Glu Ser Ser Val Ile Pro Leu Arg His 
                405                 410                 415     


Pro Leu Ala Asp Pro Ser Thr Val Phe Lys Gly Asp Asp Glu Ala Glu 
            420                 425                 430         


Glu Phe Val Glu Val His Leu Pro Asp Thr Gln Lys Gln Ile Ser Gly 
        435                 440                 445             


Ile Asp Leu Gly Leu Pro Glu Trp Lys Arg Tyr Phe Leu Met Gly Met 
    450                 455                 460                 


Ser Ala Ile Gly Phe Leu Ala Leu Thr Ile Ile Leu Ala Val Cys Cys 
465                 470                 475                 480 


Arg Arg Ile Lys Arg Arg Lys Gln Ser Lys Pro Asn Pro Val Glu Leu 
                485                 490                 495     


Ile Arg Lys Val Ser Val Thr Ser Gln Ser Gly Arg Ala Ile Pro Ser 
            500                 505                 510         


Trp Glu Ser Tyr Lys Val Lys Thr Gly Asp Gln Pro Gln Val 
        515                 520                 525     


<210>  515
<211>  525
<212>  PRT
<213>  Australian bat lyssavirus

<400>  515

Met Leu Leu Gln Val Ile Leu Leu Val Ser Leu Thr Ala Ile Leu Pro 
1               5                   10                  15      


Cys Thr Gly Gln Phe Pro Leu Tyr Ala Ile Pro Asp Lys Leu Gly Pro 
            20                  25                  30          


Trp Ser Pro Ile Asp Ile His His Leu Ser Cys Pro Asn Asn Leu Ile 
        35                  40                  45              


Val Glu Asp Glu Gly Cys Thr Ser Leu Ser Gly Phe Ser Tyr Met Glu 
    50                  55                  60                  


Leu Lys Val Gly Phe Ile Thr Thr Ile Lys Val Ser Gly Phe Thr Cys 
65                  70                  75                  80  


Thr Gly Val Val Thr Glu Ser Glu Thr Tyr Thr Asn Phe Phe Gly Tyr 
                85                  90                  95      


Val Thr Thr Thr Phe Lys Arg Lys His Phe Arg Pro Thr Pro Glu Ser 
            100                 105                 110         


Cys Arg Lys Ala Tyr Asn Trp Lys Ile Ala Gly Asp Pro Arg Tyr Glu 
        115                 120                 125             


Glu Ser Leu His Asn Pro Tyr Pro Asp Tyr His Trp Leu Arg Thr Val 
    130                 135                 140                 


Thr Thr Thr Lys Glu Ser Leu Leu Ile Ile Ser Pro Ser Val Val Asp 
145                 150                 155                 160 


Met Asp Pro Tyr Asp Lys Ser Leu His Ser Arg Met Phe Pro Lys Gly 
                165                 170                 175     


Ser Cys Ser Gly Ala Ser Ile Pro Ser Val Phe Cys Ser Thr Asn His 
            180                 185                 190         


Asp Tyr Thr Leu Trp Met Pro Glu Asp Ser Asn Ser Gly Met Ser Cys 
        195                 200                 205             


Asp Ile Phe Thr Met Ser Lys Gly Lys Lys Ala Ser Lys Gly Gly Lys 
    210                 215                 220                 


Val Cys Gly Phe Val Asp Glu Arg Gly Leu Tyr Lys Ser Leu Lys Gly 
225                 230                 235                 240 


Ala Cys Lys Leu Lys Leu Cys Gly Ile Ser Gly Leu Arg Leu Leu Asp 
                245                 250                 255     


Gly Ser Trp Val Ser Ile Gln Asn His Glu Glu Val Lys Trp Cys Ser 
            260                 265                 270         


Pro Asn Gln Leu Val Asn Ile His Asp Phe Asn Ala Asp Glu Ile Glu 
        275                 280                 285             


His Leu Ile Val Glu Glu Leu Ile Lys Glu Arg Glu Glu Cys Leu Asp 
    290                 295                 300                 


Ala Leu Glu Ser Ile Ile Thr Thr Lys Ser Val Ser Phe Arg Arg Leu 
305                 310                 315                 320 


Ser His Leu Arg Lys Leu Val Pro Gly Phe Gly Lys Ala Tyr Thr Ile 
                325                 330                 335     


Ile Asn Lys Thr Leu Met Glu Ala Asp Ala His Tyr Lys Ser Val Arg 
            340                 345                 350         


Thr Trp Asp Glu Ile Ile Pro Ser Lys Gly Cys Leu Lys Val Arg Glu 
        355                 360                 365             


Lys Cys His Pro Pro Tyr Asn Gly Val Phe Phe Asn Gly Ile Ile Leu 
    370                 375                 380                 


Gly Pro Asp Gly Gln Val Leu Ile Pro Glu Met Gln Ser Ser Leu Leu 
385                 390                 395                 400 


His Gln His Thr Glu Leu Leu Glu Ser Ser Val Ile Pro Leu Ile His 
                405                 410                 415     


Pro Leu Ala Asp Pro Ser Thr Ile Phe Arg Gly Asp Asp Glu Ala Glu 
            420                 425                 430         


Gly Phe Ile Glu Val His Leu Pro Asp Ile Gln Lys Gln Val Ser Gly 
        435                 440                 445             


Ile Asp Leu Gly Leu Ser Glu Trp Glu Arg Tyr Leu Ile Ile Gly Ile 
    450                 455                 460                 


Ser Ala Ile Ile Leu Phe Ile Leu Ala Ile Ile Phe Thr Ile Cys Cys 
465                 470                 475                 480 


Arg Arg Cys Lys Arg Arg Lys Lys Ile Arg Thr Asp His Ile Glu Leu 
                485                 490                 495     


Asp Arg Lys Val Ser Val Thr Ser Gln Ser Gly Lys Ser Ile Pro Ser 
            500                 505                 510         


Trp Glu Ser Tyr Lys Ser Arg Gln Gly His Ser Arg Ser 
        515                 520                 525 


<210>  516
<211>  524
<212>  PRT
<213>  Bokeloh bat lyssavirus

<400>  516

Met Pro Thr Gln Ala Val Leu Thr Ala Phe Leu Thr Thr Ile Thr Val 
1               5                   10                  15      


Cys Val Gly Lys Phe Pro Ile Tyr Thr Ile Pro Asp Lys Leu Gly Pro 
            20                  25                  30          


Trp Ser Pro Ile Asp Ile Asn His Leu Ser Cys Pro Asn Asn Leu Val 
        35                  40                  45              


Val Glu Asp Glu Gly Cys Thr Asn Leu Ser Gly Phe Thr Tyr Met Glu 
    50                  55                  60                  


Leu Lys Val Gly Tyr Ile Thr Thr Ile Lys Val Ser Gly Phe Thr Cys 
65                  70                  75                  80  


Thr Gly Val Val Thr Glu Ala Glu Thr Tyr Thr Asn Phe Val Gly Tyr 
                85                  90                  95      


Val Thr Thr Thr Phe Lys Arg Lys His Phe Arg Pro Arg Pro Asp Ala 
            100                 105                 110         


Cys Arg Glu Ala Tyr Asp Trp Lys Thr Ala Gly Asp Pro Arg Tyr Glu 
        115                 120                 125             


Glu Ser Leu His Asn Pro Tyr Pro Asp Ser His Trp Leu Arg Thr Val 
    130                 135                 140                 


Ser Thr Thr Lys Glu Ser Phe Leu Ile Ile Glu Pro Ser Val Ala Asp 
145                 150                 155                 160 


Met Asp Ala Tyr Asp Lys Ser Leu Tyr Ser Lys Ile Phe Pro Asp Gly 
                165                 170                 175     


Lys Cys Ser Gly Val Ser Ala Val Ser Pro Phe Cys Pro Thr Asn His 
            180                 185                 190         


Glu Tyr Thr Ile Trp Met Ser Glu Asn Pro Lys Pro Gly Met Ser Cys 
        195                 200                 205             


Asp Ile Phe Thr Thr Ser Lys Gly Lys Lys Ala Met Lys Asn Gly Lys 
    210                 215                 220                 


Met Cys Gly Phe Val Asp Glu Arg Gly Leu Tyr Lys Ser Leu Lys Gly 
225                 230                 235                 240 


Ala Cys Lys Leu Lys Leu Cys Gly Val Ser Gly Leu Arg Leu Met Asp 
                245                 250                 255     


Gly Ser Trp Val Ser Val Gln Asn Pro Glu Asp Ala Lys Trp Cys Ser 
            260                 265                 270         


Pro Asp Gln Leu Val Asn Ile His Asp Phe His Ser Asp Glu Val Glu 
        275                 280                 285             


His Leu Ile Val Glu Glu Leu Val Lys Lys Arg Glu Glu Cys Leu Asp 
    290                 295                 300                 


Ala Leu Glu Ser Ile Met Thr Thr Lys Ser Val Ser Phe Arg Arg Leu 
305                 310                 315                 320 


Ser His Leu Arg Lys Leu Val Pro Gly Phe Gly Lys Ala Tyr Thr Ile 
                325                 330                 335     


Ile Asn Lys Thr Leu Met Glu Ala Asp Ala His Tyr Lys Ser Ile Arg 
            340                 345                 350         


Gln Trp Thr Glu Ile Ile Pro Ser Lys Gly Cys Leu Met Ala Gly Gly 
        355                 360                 365             


Arg Cys Tyr Pro His His Asn Gly Val Phe Phe Asn Gly Ile Ile Leu 
    370                 375                 380                 


Ser Pro Asp Gly His Val Leu Ile Pro Glu Met Gln Ser Ala Leu Leu 
385                 390                 395                 400 


Gln Gln His Ile Glu Leu Leu Glu Ser Ser Val Ile Pro Leu Met His 
                405                 410                 415     


Pro Leu Ala Asp Pro Ser Asn Ala Leu Lys Gly Gly Asp Gly Ala Glu 
            420                 425                 430         


Asp Phe Val Glu Val His Leu Pro Asp Val Gln Lys Gln Ile Ser Gly 
        435                 440                 445             


Ile Asp Leu Gly Leu Pro Glu Trp Lys Arg Tyr Phe Leu Met Gly Val 
    450                 455                 460                 


Ser Ala Leu Ala Leu Leu Ala Leu Ile Ile Ile Leu Ala Thr Cys Cys 
465                 470                 475                 480 


Lys Arg Ile Lys Arg Lys Lys Lys Met Lys Ser Ser Pro Val Glu Leu 
                485                 490                 495     


Ile Arg Lys Val Ser Val Thr Ser Gln Ser Gly Arg Val Val Pro Ser 
            500                 505                 510         


Trp Glu Ser Tyr Lys Val Asp Ala Gly Gly His Ala 
        515                 520                 


<210>  517
<211>  533
<212>  PRT
<213>  Duvenhage lyssavirus

<400>  517

Met Pro Leu Asn Ala Val Ile Phe Thr Leu Leu Leu Arg Cys Ser Ile 
1               5                   10                  15      


Cys Leu Gly Lys Phe Pro Phe Tyr Thr Ile Pro Asp Lys Leu Gly Pro 
            20                  25                  30          


Trp Ser Pro Ile Asp Ile His His Leu Ser Cys Pro Asn Asn Leu Val 
        35                  40                  45              


Val Glu Asp Glu Gly Cys Thr Thr Leu Thr Pro Phe Ser Tyr Met Glu 
    50                  55                  60                  


Leu Lys Val Gly Tyr Ile Thr Ser Ile Lys Val Ser Gly Phe Thr Cys 
65                  70                  75                  80  


Thr Gly Val Val Thr Glu Ala Glu Thr Tyr Thr Asn Phe Val Gly Tyr 
                85                  90                  95      


Val Thr Thr Thr Phe Arg Arg Arg His Phe Arg Pro Ser Val Asn Ser 
            100                 105                 110         


Cys Arg Asp Ala Tyr Asn Trp Lys Ile Ala Gly Asp Pro Arg Tyr Glu 
        115                 120                 125             


Glu Ser Leu His Asn Pro Tyr Pro Asp Ser His Trp Leu Arg Thr Val 
    130                 135                 140                 


Lys Thr Thr Lys Glu Ser Leu Leu Ile Ile Ser Pro Ser Val Ala Asp 
145                 150                 155                 160 


Met Asp Ala Tyr Asp Lys Lys Leu Tyr Ser Lys Ile Val Ser Asn Gly 
                165                 170                 175     


Arg Cys Ser Glu Ile Ser Pro Gly Ser Pro Phe Cys Pro Thr Asn His 
            180                 185                 190         


Glu Tyr Thr Ile Trp Met Pro Glu Ser Ser Asn Pro Gly Ile Ser Cys 
        195                 200                 205             


Asp Ile Phe Thr Arg Ser Met Gly Lys Lys Ala Thr Lys Asp Gly Gln 
    210                 215                 220                 


Leu Cys Gly Phe Val Asp Glu Arg Gly Leu Tyr Lys Ser Leu Lys Gly 
225                 230                 235                 240 


Ala Cys Arg Leu Arg Leu Cys Gly Ile Ser Gly Leu Arg Leu Met Asp 
                245                 250                 255     


Gly Ser Trp Val Ser Leu Pro Gln Val Asn Asn Ser Glu Trp Cys Ser 
            260                 265                 270         


Pro Asp Gln Leu Val Asn Ile His Asp Phe His Ser Asp Glu Ile Glu 
        275                 280                 285             


His Leu Val Ala Asp Glu Leu Val Lys Lys Arg Glu Asp Cys Leu Asp 
    290                 295                 300                 


Ala Leu Glu Thr Ile Leu Phe Thr Lys Ser Ile Ser Phe Arg Arg Leu 
305                 310                 315                 320 


Ser His Leu Arg Lys Leu Val Pro Gly Phe Gly Lys Ala Tyr Thr Ile 
                325                 330                 335     


Ile Asn Arg Thr Leu Met Glu Ala Glu Ala His Tyr Lys Ser Val Arg 
            340                 345                 350         


Glu Trp Lys Glu Ile Ile Pro Ser Lys Gly Cys Leu Lys Ala Gly Gly 
        355                 360                 365             


Arg Cys Tyr Pro His His Asn Gly Ile Phe Phe Asn Gly Ile Ile Leu 
    370                 375                 380                 


Gly Pro Gly Gly Glu Ile Leu Ile Pro Glu Met Gln Ser Ala Leu Leu 
385                 390                 395                 400 


Gln Gln His Ile Glu Leu Leu Glu Ser Ser Val Val Pro Leu Lys His 
                405                 410                 415     


Pro Leu Ala Asp Pro Ser Thr Val Phe Lys Asn Asp Asp Glu Ala Glu 
            420                 425                 430         


Ser Phe Val Asp Val His Leu Pro Asp Thr Asn Gln Lys Ile Ser Gly 
        435                 440                 445             


Ile Asp Leu Gly Leu Pro Glu Trp Lys Arg Tyr Phe Leu Ile Gly Val 
    450                 455                 460                 


Ser Ala Val Ala Leu Leu Ala Leu Ser Ile Ile Ile Ala Val Cys Cys 
465                 470                 475                 480 


Lys Arg Phe Arg Lys Arg Lys Lys Ser Lys Pro Gly Pro Val Glu Leu 
                485                 490                 495     


Thr Arg Lys Val Ser Val Ile Ser Lys Gly Asn Gly Pro Val Pro Ser 
            500                 505                 510         


Trp Glu Ser Tyr Lys Glu Gly Thr Thr Gly Asp Val Arg Asn Thr Thr 
        515                 520                 525             


Pro Ser Thr Arg Glu 
    530             


<210>  518
<211>  524
<212>  PRT
<213>  European bat 1 lyssavirus

<400>  518

Met Leu Leu Ser Thr Ala Ile Phe Ala Phe Phe Leu Asn Cys Ala Pro 
1               5                   10                  15      


Cys Leu Ala Lys Phe Pro Ile Tyr Thr Ile Pro Asp Lys Ile Gly Pro 
            20                  25                  30          


Trp Ser Pro Ile Asp Ile Asn His Leu Ser Cys Pro Asn Asn Leu Ile 
        35                  40                  45              


Val Glu Asp Glu Gly Cys Thr Thr Leu Thr Pro Phe Ser Tyr Met Glu 
    50                  55                  60                  


Leu Lys Val Gly Tyr Ile Thr Thr Ile Lys Ile Glu Gly Phe Thr Cys 
65                  70                  75                  80  


Thr Gly Val Ile Thr Glu Ala Glu Thr Tyr Thr Asn Phe Val Gly Tyr 
                85                  90                  95      


Val Thr Thr Thr Phe Lys Arg Lys His Phe Arg Pro Thr Val Ser Ala 
            100                 105                 110         


Cys Arg Asp Ala Tyr Asn Trp Lys Ile Thr Gly Asp Pro Arg Tyr Glu 
        115                 120                 125             


Glu Ser Leu His Asn Pro Tyr Pro Asp Ser His Trp Leu Arg Thr Val 
    130                 135                 140                 


Lys Thr Thr Lys Glu Ser Leu Leu Ile Ile Ser Pro Ser Val Val Asp 
145                 150                 155                 160 


Met Asp Ala Tyr Asp Lys Asn Leu Tyr Ser Lys Met Phe Pro Asn Gly 
                165                 170                 175     


Lys Cys Leu Ala Ser Pro Pro Ser Ala Ile Cys Cys Pro Thr Asn His 
            180                 185                 190         


Asp Tyr Thr Ile Trp Ile Pro Glu Asn Pro Lys Pro Gly Leu Ser Cys 
        195                 200                 205             


Asp Ile Phe Thr Thr Ser Lys Gly Lys Lys Ala Thr Lys Asp Gly Arg 
    210                 215                 220                 


Leu Cys Gly Phe Val Asp Glu Arg Gly Leu Tyr Lys Ser Leu Lys Gly 
225                 230                 235                 240 


Ala Cys Lys Gln Arg Leu Cys Gly Val Pro Gly Met Arg Leu Met Asp 
                245                 250                 255     


Gly Ser Trp Val Ser Leu Gln Lys Thr Glu Ala Pro Glu Trp Cys Ser 
            260                 265                 270         


Pro Asp Gln Leu Val Asn Val His Asp Phe His Thr Asp Glu Ile Glu 
        275                 280                 285             


His Leu Val Val Glu Glu Leu Val Lys Lys Arg Glu Glu Cys Leu Asp 
    290                 295                 300                 


Ala Leu Glu Thr Ile Ile Thr Thr Lys Ser Ile Ser Phe Arg Arg Leu 
305                 310                 315                 320 


Ser His Phe Arg Lys Leu Val Pro Gly Phe Gly Lys Ala Tyr Thr Leu 
                325                 330                 335     


Ile Asn Lys Thr Leu Met Glu Ala Asp Ala His Tyr Lys Ser Val Arg 
            340                 345                 350         


Glu Trp Lys Glu Val Ile Pro Ser Lys Gly Cys Leu Met Ala Gly Gly 
        355                 360                 365             


Arg Cys His Pro His Tyr Ser Gly Ile Phe Phe Asn Gly Ile Ile Leu 
    370                 375                 380                 


Ser Pro Gly Gly Asp Val Leu Ile Pro Glu Met Gln Ser Ala Leu Leu 
385                 390                 395                 400 


Gln Gln His Ile Glu Leu Leu Glu Ser Ser Met Ile Pro Leu Arg His 
                405                 410                 415     


Pro Leu Ala Asp Pro Ser Thr Val Phe Lys Arg Asp Asp Glu Ala Glu 
            420                 425                 430         


Asp Phe Val Glu Val His Leu Pro Asp Thr Gln Lys Leu Ile Ser Gly 
        435                 440                 445             


Ile Asp Leu Gly Phe Pro Glu Trp Lys Arg Tyr Phe Leu Ile Gly Ile 
    450                 455                 460                 


Ser Val Leu Ala Leu Leu Ala Leu Ala Ile Ile Thr Ala Ala Cys Cys 
465                 470                 475                 480 


Lys Arg Phe Lys Arg Arg Arg Arg Pro Lys Pro Asn Pro Ile Glu Leu 
                485                 490                 495     


Ile Arg Lys Val Ser Val Thr Ser Gln Ser Gly Arg Ala Ile Pro Ser 
            500                 505                 510         


Trp Glu Ser Tyr Lys Val Gly Ala Thr Gly Glu Ser 
        515                 520                 


<210>  519
<211>  524
<212>  PRT
<213>  European bat 2 lyssavirus

<400>  519

Met Pro Phe Gln Ala Val Leu Ser Ala Leu Leu Ser Ala Leu Thr Leu 
1               5                   10                  15      


Cys Val Gly Lys Phe Pro Ile Tyr Thr Ile Pro Asp Lys Leu Gly Pro 
            20                  25                  30          


Trp Ser Pro Ile Asp Ile His His Leu Ser Cys Pro Asn Asn Ile Val 
        35                  40                  45              


Val Glu Asp Glu Gly Cys Thr Thr Leu Thr Val Phe Ser Tyr Met Glu 
    50                  55                  60                  


Leu Lys Val Gly Tyr Ile Thr Thr Ile Lys Val Asn Gly Phe Thr Cys 
65                  70                  75                  80  


Thr Gly Val Val Thr Glu Ala Glu Thr Tyr Thr Asn Phe Val Gly Tyr 
                85                  90                  95      


Val Thr Thr Thr Phe Lys Arg Lys His Phe Arg Pro Ser Pro Ser Ala 
            100                 105                 110         


Cys Arg Asp Ala Tyr Ser Trp Lys Thr Ala Gly Asp Pro Arg Tyr Glu 
        115                 120                 125             


Glu Ser Leu His Asn Pro Tyr Pro Asp Ser His Trp Leu Arg Thr Val 
    130                 135                 140                 


Thr Thr Thr Lys Glu Ser Val Leu Ile Ile Ser Pro Ser Val Ala Asp 
145                 150                 155                 160 


Met Asp Ala Tyr Asp Lys Thr Leu Tyr Ser Lys Ile Phe Leu Asn Gly 
                165                 170                 175     


Lys Cys Ser Gly Val Ser Gln Val Ser Pro Phe Cys Ser Thr Asn His 
            180                 185                 190         


Asp Tyr Thr Ile Trp Met Pro Glu Asn Pro Asn Pro Gly Val Ser Cys 
        195                 200                 205             


Asp Ile Phe Thr Thr Ser Lys Gly Lys Lys Ala Thr Lys Asp Gly Lys 
    210                 215                 220                 


Leu Cys Gly Phe Val Asp Glu Arg Gly Leu Tyr Lys Ser Leu Lys Gly 
225                 230                 235                 240 


Ala Cys Lys Leu Lys Leu Cys Gly Ile Ser Gly Met Arg Leu Met Asp 
                245                 250                 255     


Gly Ser Trp Val Ser Ile Gln Asn His Asp Glu Ala Lys Trp Cys Ser 
            260                 265                 270         


Pro Asp Gln Leu Val Asn Ile His Asp Phe His Ser Asp Glu Val Glu 
        275                 280                 285             


His Leu Ile Ala Glu Glu Leu Val Lys Lys Arg Glu Glu Cys Leu Asp 
    290                 295                 300                 


Ala Leu Glu Ser Ile Met Thr Thr Lys Ser Ile Ser Phe Arg Arg Leu 
305                 310                 315                 320 


Ser His Leu Arg Lys Leu Val Pro Gly Phe Gly Lys Ala Tyr Thr Ile 
                325                 330                 335     


Ile Asn Lys Thr Leu Met Glu Ala Asp Ala His Tyr Lys Ser Ile Arg 
            340                 345                 350         


Glu Trp Thr Asp Val Ile Pro Ser Lys Gly Cys Leu Met Ala Gly Gly 
        355                 360                 365             


Arg Cys Tyr Pro His His Asn Gly Val Phe Phe Asn Gly Ile Ile Leu 
    370                 375                 380                 


Ser Pro Asp Gly His Val Leu Ile Pro Glu Met Gln Ser Ala Met Leu 
385                 390                 395                 400 


Gln Gln His Ile Glu Leu Leu Glu Ser Ser Val Ile Pro Leu Met His 
                405                 410                 415     


Pro Leu Ala Asp Pro Ser Thr Ile Phe Lys Lys Asp Asp Gly Ala Glu 
            420                 425                 430         


Asp Phe Val Glu Val His Leu Pro Asp Val Gln Lys Gln Ile Ser Gly 
        435                 440                 445             


Ile Asp Leu Gly Leu Pro Glu Trp Lys Arg Tyr Phe Leu Ile Gly Val 
    450                 455                 460                 


Ser Ala Leu Ala Phe Leu Ala Leu Met Ile Phe Ile Ala Ala Cys Cys 
465                 470                 475                 480 


Arg Arg Val Lys Arg Lys Lys Arg Ala Lys Pro Asn Pro Val Glu Leu 
                485                 490                 495     


Ile Arg Lys Val Ser Val Thr Ser Gln Ser Gly Arg Pro Ile Pro Ser 
            500                 505                 510         


Trp Glu Ser Tyr Lys Val Glu Thr Gly Gly Gln Ser 
        515                 520                 


<210>  520
<211>  526
<212>  PRT
<213>  Gannoruwa bat lyssavirus

<400>  520

Met Val His Lys Ala Phe Leu Leu Ile Leu Leu Leu Val Ser Pro Pro 
1               5                   10                  15      


Cys Leu Gly Lys Phe Pro Ile Tyr Thr Ile Pro Asp Lys Leu Gly Pro 
            20                  25                  30          


Trp Ser Pro Ile Asp Ile His His Leu Ser Cys Pro Asn Asn Leu Ile 
        35                  40                  45              


Val Glu Asp Glu Gly Cys Thr Ser Leu Ser Gly Phe Ser Tyr Met Glu 
    50                  55                  60                  


Leu Lys Val Gly Tyr Ile Thr Thr Ile Lys Val Ser Gly Phe Thr Cys 
65                  70                  75                  80  


Thr Gly Val Val Thr Glu Ala Glu Thr Tyr Thr Asn Phe Val Gly Tyr 
                85                  90                  95      


Val Thr Thr Thr Phe Lys Arg Lys His Phe Arg Pro Thr Pro Asp Gly 
            100                 105                 110         


Cys Arg Asn Ala Tyr Asn Trp Lys Thr Ala Gly Asp Pro Arg Tyr Glu 
        115                 120                 125             


Glu Ser Leu His Asn Pro Tyr Pro Asp Tyr His Trp Leu Arg Thr Val 
    130                 135                 140                 


Thr Thr Thr Lys Glu Ser Leu Leu Ile Ile Ser Pro Ser Val Val Asp 
145                 150                 155                 160 


Met Asp Pro Tyr Asp Lys Ser Leu His Ser Lys Val Phe Pro Thr Gly 
                165                 170                 175     


Arg Cys Ser Gly Ile Ser Val Ser Ser Thr Ser Cys Ser Thr Asn His 
            180                 185                 190         


Asp Tyr Thr Leu Trp Leu Pro Glu Asp Pro Lys Pro Gly Ser Ser Cys 
        195                 200                 205             


Asp Ile Phe Thr Thr Ser Lys Gly Lys Lys Ala Ser Lys Gly Gly Lys 
    210                 215                 220                 


Ile Cys Gly Phe Val Asp Glu Arg Gly Leu Tyr Lys Ser Leu Lys Gly 
225                 230                 235                 240 


Ser Cys Lys Leu Lys Leu Cys Gly Ile Ser Gly Leu Arg Leu Met Asp 
                245                 250                 255     


Gly Ser Trp Val Ser Ile Gln Asn Pro Glu Asp Thr Lys Trp Cys Ser 
            260                 265                 270         


Ser Asp Gln Leu Val Ser Ile His Asp Phe His Ser Asp Glu Ile Glu 
        275                 280                 285             


His Leu Val Val Glu Glu Leu Val Lys Lys Arg Glu Glu Cys Leu Asp 
    290                 295                 300                 


Ala Leu Glu Ser Ile Val Thr Thr Lys Ser Val Ser Phe Arg Arg Leu 
305                 310                 315                 320 


Ser His Leu Arg Lys Leu Val Pro Gly Phe Gly Lys Ala Tyr Thr Ile 
                325                 330                 335     


Val Asn Lys Thr Leu Met Glu Ala Asp Ala His Tyr Lys Ser Val Arg 
            340                 345                 350         


Ala Trp Asn Glu Ile Ile Pro Ser Lys Gly Cys Leu Lys Val Gly Glu 
        355                 360                 365             


Arg Cys Tyr Pro Pro Phe Asn Gly Val Phe Phe Asn Gly Ile Ile Leu 
    370                 375                 380                 


Gly Pro Asp Gly His Val Leu Ile Pro Glu Met Gln Ser Ser Leu Leu 
385                 390                 395                 400 


Gln Gln His Met Glu Leu Leu Glu Ser Ser Met Ile Pro Leu Met His 
                405                 410                 415     


Pro Leu Ala Asp Pro Ser Thr Val Phe Arg Gly Asp Asp Glu Ala Glu 
            420                 425                 430         


Asp Phe Val Glu Val His Leu Pro Asp Val Gln Lys Gln Ile Ser Gly 
        435                 440                 445             


Val Asp Leu Gly Leu Ser Glu Trp Glu Arg Tyr Leu Leu Ile Gly Val 
    450                 455                 460                 


Ala Ala Leu Gly Leu Phe Ala Phe Ala Ile Ile Leu Ala Val Cys Cys 
465                 470                 475                 480 


Arg Arg Gly Arg Arg Arg Lys Arg Thr Pro Ser Asp Pro Met Glu Met 
                485                 490                 495     


Ile Arg Lys Val Ser Val Thr Ser Gln Ser Gly Lys Met Val Pro Ser 
            500                 505                 510         


Trp Glu Ser Tyr Lys Asn Gly Asn Gly Ser Arg Leu Gly Val 
        515                 520                 525     


<210>  521
<211>  524
<212>  PRT
<213>  Ikoma lyssavirus

<400>  521

Met Ala Gln Leu Val Thr Leu Val Leu Asn Gly Leu Ser Leu Leu Thr 
1               5                   10                  15      


Gly Pro Gly Ile Phe Pro Met Tyr Thr Ile Pro Glu Gly Leu Gly Pro 
            20                  25                  30          


Trp Thr Pro Ile Asp Leu Ser His Leu Lys Cys Pro Asp Asn Thr Tyr 
        35                  40                  45              


Phe Ala Glu Glu Gly Cys Asn Glu Gly Ser Lys Val Ser Tyr Leu Glu 
    50                  55                  60                  


Leu Lys Pro Ser Phe His Ser Gln Asn Lys Val Gln Gly Phe Thr Cys 
65                  70                  75                  80  


Thr Gly Ile Ile Asn Met Ala Thr Thr Tyr Thr Asn Phe Val Gly Tyr 
                85                  90                  95      


Val Thr Thr Thr Phe Gln Arg Ser His Phe Ile Pro Asn Gln Arg Asp 
            100                 105                 110         


Cys Arg Gln Ala Arg Glu Trp Lys Lys Glu Gly Asp Pro Arg Tyr Glu 
        115                 120                 125             


Glu Ser Leu Thr Thr Pro Tyr Pro Asp Ser Lys Trp Leu Arg Thr Val 
    130                 135                 140                 


Thr Thr Ser Lys Glu Ser Trp Leu Ile Leu Asp Pro Ala Val Val Glu 
145                 150                 155                 160 


Met Asp Ile Tyr Asn Lys Thr Met Phe Ser Pro Val Leu Arg Asn Gly 
                165                 170                 175     


Tyr Cys Asn Phe Ser Pro Glu Asn Pro Asp Phe Cys Glu Thr Asn His 
            180                 185                 190         


Gln His Ser Ile Trp Ile Pro Glu Asp Glu Gly Arg Gly Ile Thr Cys 
        195                 200                 205             


Asp Ile Phe Gln Ala Ser Thr Gly Ile Leu Leu Lys Asn Gly Ser Lys 
    210                 215                 220                 


Val Cys Gly Phe Gln Asp Glu Arg Gly Leu Phe Arg Ser Ile Lys Gly 
225                 230                 235                 240 


Ala Cys Lys Met Ile Ile Cys Gly Lys Ser Gly Val Arg Leu Tyr Asp 
                245                 250                 255     


Gly Thr Trp Val Ser Tyr Asn Ser Val Asp Asn Leu Arg Met Cys Ser 
            260                 265                 270         


Arg Ser Lys Met Val Asn Lys His Thr Val Lys Leu Asp Asn Ile Glu 
        275                 280                 285             


Glu Ser Ile Val Arg Asp Leu Ile Lys Lys Arg Glu Glu Cys Leu Asp 
    290                 295                 300                 


Ala Leu Glu Glu Val Met Leu Thr Arg Ser Ile Ser Phe Arg Lys Leu 
305                 310                 315                 320 


Ser Leu Phe Arg Lys Gln Val Pro Gly Arg Gly Tyr Val Tyr Thr Met 
                325                 330                 335     


Ile Asn Asn Thr Met Met Glu Ala Thr Gly His Tyr Lys Ser Val Asp 
            340                 345                 350         


Asn Trp Thr Asp Ile Leu Pro Asn Pro Ile Cys Leu Met Val Asp Gly 
        355                 360                 365             


Lys Cys His Pro Gly Tyr Asp Gly Val Leu Phe Asn Gly Ile Ile Arg 
    370                 375                 380                 


Asp Ser Arg Gly Lys Ile Leu Ile Pro Glu Met Gln Ser His Leu Leu 
385                 390                 395                 400 


Arg Asp His Leu Glu Leu Leu Lys Arg Asn Ser Ile Pro Trp Arg His 
                405                 410                 415     


Pro Leu Val His Tyr Ser Glu Asn Gly Glu Asp Gly Ser Asp Leu Thr 
            420                 425                 430         


Ser Phe Ala Gln Leu Tyr Ile Lys Asp Pro His Leu Ser Val Ser Asp 
        435                 440                 445             


Ile Asp Ile Gly Phe Pro Ser Trp Lys Lys Tyr Leu Met Ile Val Gly 
    450                 455                 460                 


Gly Val Leu Ile Gly Leu Ile Val Phe Trp Phe Leu Val Lys Leu Leu 
465                 470                 475                 480 


Phe Arg Val Cys Tyr Thr Val Lys Arg Lys Arg Leu Arg Glu Gly Ser 
                485                 490                 495     


Met Asn Glu Thr Ser Ser Gly Pro Val Ile Arg Thr Ser Gly Asp Lys 
            500                 505                 510         


Gln Leu Ser Trp Glu Ser Tyr Lys Ser Ser Ala Phe 
        515                 520                 


<210>  522
<211>  524
<212>  PRT
<213>  Irkut lyssavirus

<400>  522

Met Ser Leu Leu Thr Ala Val Ile Ala Phe Leu Phe Ile Ser Thr Phe 
1               5                   10                  15      


Cys Ser Gly Lys Phe Pro Ile Tyr Thr Ile Pro Asp Lys Ile Gly Pro 
            20                  25                  30          


Trp Ser Pro Ile Asp Ile Asn His Leu Ser Cys Pro Asn Asn Leu Glu 
        35                  40                  45              


Val Glu Asp Glu Gly Cys Thr Thr Leu Thr Ala Phe Asn Tyr Met Glu 
    50                  55                  60                  


Leu Lys Val Gly Tyr Ile Thr Ser Ile Lys Val Asp Gly Phe Thr Cys 
65                  70                  75                  80  


Thr Gly Val Val Thr Glu Ala Glu Thr Tyr Thr Asn Phe Val Gly Tyr 
                85                  90                  95      


Val Thr Thr Thr Phe Lys Arg Lys His Phe Arg Pro Asn Val Ser Ala 
            100                 105                 110         


Cys Arg Ala Ala Phe Ser Trp Lys Thr Ala Gly Asp Pro Arg Tyr Glu 
        115                 120                 125             


Glu Ser Leu His Asn Pro Tyr Pro Asp Ser His Trp Leu Arg Thr Val 
    130                 135                 140                 


Thr Thr Thr Lys Glu Ser Leu Leu Ile Ile Ser Pro Ser Val Val Asp 
145                 150                 155                 160 


Met Asp Ala Tyr Asp Lys Thr Leu Tyr Ser Lys Met Phe Pro Asn Gly 
                165                 170                 175     


Lys Cys Phe Pro Pro Ile Ser Asp Ser Pro Phe Cys Ser Thr Asn His 
            180                 185                 190         


Asp Tyr Thr Leu Trp Leu Pro Glu Lys Glu Lys Leu Ser Met Ser Cys 
        195                 200                 205             


Asn Ile Phe Val Ser Ser Lys Gly Lys Lys Ala Thr Lys Asp Gly Arg 
    210                 215                 220                 


Leu Cys Gly Phe Val Asp Glu Arg Gly Leu Tyr Lys Ser Leu Lys Gly 
225                 230                 235                 240 


Ala Cys Lys Leu Lys Leu Cys Gly Met Ala Gly Met Arg Leu Met Asp 
                245                 250                 255     


Gly Ser Trp Val Ser Leu Gln Arg Ala Asp Ala Pro Glu Trp Cys Pro 
            260                 265                 270         


Pro Gly Ala Leu Val Asn Val His Asp Phe His Ser Asp Glu Ile Ala 
        275                 280                 285             


His Phe Val Val Glu Glu Leu Ile Lys Lys Arg Glu Glu Cys Leu Asp 
    290                 295                 300                 


Thr Leu Glu Thr Ile Leu Thr Thr Lys Ser Ile Ser Phe Arg Arg Leu 
305                 310                 315                 320 


Ser His Phe Arg Lys Leu Val Pro Gly Leu Gly Lys Ala Tyr Thr Leu 
                325                 330                 335     


Ile Asn Asn Thr Leu Met Glu Ala Glu Ala His Tyr Lys Ser Ile Arg 
            340                 345                 350         


Glu Trp Lys Glu Ile Ile Pro Ser Lys Gly Cys Leu Lys Ala Gly Gly 
        355                 360                 365             


Arg Cys His Pro His Tyr Asp Gly Ile Phe Phe Asn Gly Ile Ile Leu 
    370                 375                 380                 


Gly Pro Asn Gly Asp Val Leu Ile Pro Glu Met Gln Ser Ser Leu Leu 
385                 390                 395                 400 


Gln Gln His Ile Glu Leu Leu Glu Ser Ser Met Ile Pro Leu Arg His 
                405                 410                 415     


Pro Leu Ala Asp Ser Ser Ala Ile Phe Arg Ser Asp Asn Glu Ala Glu 
            420                 425                 430         


Asp Phe Val Asp Val His Leu Pro Asp Thr Gln Lys Gln Val Ser Asp 
        435                 440                 445             


Ile Asp Leu Gly Phe Pro Glu Trp Lys Arg Tyr Phe Leu Ile Gly Val 
    450                 455                 460                 


Ser Ala Ile Ala Leu Phe Ser Leu Ala Ile Ile Ile Ala Val Cys Cys 
465                 470                 475                 480 


Arg Lys Phe Lys Arg Arg Lys Arg Pro Lys Pro Gly Pro Ile Glu Leu 
                485                 490                 495     


Val Arg Lys Val Ser Val Thr Ser Gln Ser Gly Lys Val Val Pro Ser 
            500                 505                 510         


Trp Glu Ser Tyr Lys Glu Gly Ala Thr Ser Gln Pro 
        515                 520                 


<210>  523
<211>  526
<212>  PRT
<213>  Khujand lyssavirus

<400>  523

Met Pro Ser Gln Ala Val Phe Leu Val Leu Thr Thr Val Phe Ser Gln 
1               5                   10                  15      


Cys Val Gly Lys Phe Pro Ile Tyr Thr Ile Pro Asp Lys Leu Gly Pro 
            20                  25                  30          


Trp Ser Pro Ile Asp Ile His His Leu Ser Cys Pro Asn Asn Leu Val 
        35                  40                  45              


Val Glu Asp Asp Gly Cys Thr Thr Leu Ser Gly Phe Thr Tyr Met Glu 
    50                  55                  60                  


Leu Lys Val Gly Tyr Ile Thr Thr Ile Lys Val Asp Gly Phe Thr Cys 
65                  70                  75                  80  


Thr Gly Ile Val Thr Glu Ala Glu Thr Tyr Thr Asn Phe Val Gly Tyr 
                85                  90                  95      


Val Thr Thr Thr Phe Lys Arg Lys His Phe Arg Pro Gly Pro Ser Ala 
            100                 105                 110         


Cys Arg Asp Ala Tyr Asn Trp Lys Ala Ala Gly Asp Pro Arg Tyr Glu 
        115                 120                 125             


Glu Ser Leu His Asn Pro Tyr Pro Asp Ser His Trp Leu Arg Thr Val 
    130                 135                 140                 


Thr Thr Thr Lys Glu Ser Leu Leu Ile Ile Ser Pro Ser Val Val Asp 
145                 150                 155                 160 


Met Asp Ala Tyr Asp Lys Ser Leu Leu Ser Lys Ile Phe Pro Asn Gly 
                165                 170                 175     


Lys Cys Pro Gly Val Ser Ile Ala Ser Pro Phe Cys Ser Thr Asn His 
            180                 185                 190         


Asp Tyr Thr Ile Trp Met Pro Glu Asn Thr Lys Thr Gly Met Ser Cys 
        195                 200                 205             


Asp Ile Phe Thr Thr Ser Lys Gly Lys Arg Ala Thr Lys Asp Gly Lys 
    210                 215                 220                 


Leu Cys Gly Phe Val Asp Glu Arg Gly Leu Tyr Lys Ser Leu Lys Gly 
225                 230                 235                 240 


Ser Cys Lys Leu Lys Leu Cys Gly Val Ser Gly Leu Arg Leu Met Asp 
                245                 250                 255     


Gly Ser Trp Val Ser Ile Gln Asn His Glu Glu Ala Lys Trp Cys Pro 
            260                 265                 270         


Pro Asp Gln Leu Val Asn Val His Asp Phe His Ser Asp Glu Ile Glu 
        275                 280                 285             


His Leu Ile Val Glu Glu Leu Val Lys Lys Arg Glu Glu Cys Leu Asp 
    290                 295                 300                 


Ala Leu Glu Ser Ile Met Thr Thr Lys Ser Ile Ser Phe Arg Arg Leu 
305                 310                 315                 320 


Ser His Leu Arg Lys Leu Val Pro Gly Phe Gly Lys Ala Tyr Thr Ile 
                325                 330                 335     


Ile Asn Lys Thr Leu Met Glu Ala Asp Ala His Tyr Lys Ser Ile Arg 
            340                 345                 350         


Glu Trp Ser Glu Ile Ile Pro Ser Lys Gly Cys Leu Val Ala Gly Gly 
        355                 360                 365             


Arg Cys Tyr His His His Asn Gly Val Phe Phe Asn Gly Ile Ile Leu 
    370                 375                 380                 


Ser Pro Asp Gly His Val Leu Ile Pro Glu Met Gln Ser Ala Leu Leu 
385                 390                 395                 400 


Gln Gln His Ile Glu Leu Leu Glu Ser Ser Val Ile Pro Leu Met His 
                405                 410                 415     


Pro Leu Ala Asp Pro Ser Thr Val Phe Lys Gly Asp Asp Gly Ala Glu 
            420                 425                 430         


Asp Phe Val Glu Val His Leu Pro Asp Val Gln Lys Gln Ile Ser Gly 
        435                 440                 445             


Ile Asp Leu Gly Leu Pro Glu Trp Lys Arg Tyr Phe Leu Ile Gly Val 
    450                 455                 460                 


Ala Ala Leu Thr Leu Phe Ala Leu Thr Ile Phe Val Val Val Cys Cys 
465                 470                 475                 480 


Arg Arg Val Arg Arg Arg Glu Arg Ala Lys Pro Asn Pro Val Glu Leu 
                485                 490                 495     


Ile Arg Lys Val Ser Val Thr Ser Gln Ser Gly Lys Val Ile Pro Ser 
            500                 505                 510         


Trp Glu Ser Tyr Lys Val Glu Ala Glu Gly Gln Ser Gln Ala 
        515                 520                 525     


<210>  524
<211>  522
<212>  PRT
<213>  Lagos bat lyssavirus

<400>  524

Met Ser Gln Leu Asn Leu Ile Pro Phe Phe Cys Val Ile Ile Val Leu 
1               5                   10                  15      


Ser Val Glu Asp Phe Pro Leu Tyr Thr Ile Pro Glu Lys Ile Gly Pro 
            20                  25                  30          


Trp Thr Pro Ile Asp Leu Ile His Leu Ser Cys Pro Asn Asn Leu Gln 
        35                  40                  45              


Ser Glu Asp Glu Gly Cys Gly Thr Ser Ser Val Phe Ser Tyr Val Glu 
    50                  55                  60                  


Leu Lys Thr Gly Tyr Leu Thr His Gln Lys Val Ser Gly Phe Thr Cys 
65                  70                  75                  80  


Thr Gly Val Val Asn Glu Ala Val Thr Tyr Thr Asn Phe Val Gly Tyr 
                85                  90                  95      


Val Thr Thr Thr Phe Lys Arg Lys His Phe Lys Pro Thr Ala Leu Ala 
            100                 105                 110         


Cys Arg Asp Ala Tyr His Trp Lys Ile Ser Gly Asp Pro Arg Tyr Glu 
        115                 120                 125             


Glu Ser Leu His Thr Pro Tyr Pro Asp Asn Ser Trp Leu Arg Thr Val 
    130                 135                 140                 


Thr Thr Thr Lys Glu Ser Leu Val Ile Ile Ser Pro Ser Ile Val Glu 
145                 150                 155                 160 


Met Asp Val Tyr Ser Arg Thr Leu His Ser Pro Met Phe Pro Thr Gly 
                165                 170                 175     


Thr Cys Ser Arg Phe Tyr Pro Ser Ser Pro Ser Cys Ala Thr Asn His 
            180                 185                 190         


Asp Tyr Thr Leu Trp Leu Pro Asp Asp Pro Asn Leu Ser Leu Ala Cys 
        195                 200                 205             


Asp Ile Phe Val Thr Ser Thr Gly Lys Lys Ser Met Asn Gly Ser Arg 
    210                 215                 220                 


Met Cys Gly Phe Thr Asp Glu Arg Gly Tyr Tyr Arg Thr Ile Lys Gly 
225                 230                 235                 240 


Ala Cys Lys Leu Thr Leu Cys Gly Lys Pro Gly Leu Arg Leu Phe Asp 
                245                 250                 255     


Gly Thr Trp Ile Ser Phe Pro Arg Pro Glu Val Thr Thr Arg Cys Leu 
            260                 265                 270         


Pro Asn Gln Leu Val Asn Ile His Asn Asn Arg Ile Asp Glu Val Glu 
        275                 280                 285             


His Leu Ile Val Glu Asp Leu Ile Arg Lys Arg Glu Glu Cys Leu Asp 
    290                 295                 300                 


Thr Leu Glu Thr Val Leu Met Ser Lys Ser Ile Ser Phe Arg Arg Leu 
305                 310                 315                 320 


Ser His Phe Arg Lys Leu Val Pro Gly Tyr Gly Lys Ala Tyr Thr Ile 
                325                 330                 335     


Leu Asn Gly Ser Leu Met Glu Thr Asn Val His Tyr Leu Lys Val Asp 
            340                 345                 350         


Asn Trp Ser Glu Ile Leu Pro Ser Lys Gly Cys Leu Lys Ile Asn Asn 
        355                 360                 365             


Gln Cys Val Ala His Tyr Lys Gly Val Phe Phe Asn Gly Ile Ile Lys 
    370                 375                 380                 


Gly Pro Asp Gly His Ile Leu Ile Pro Glu Met Gln Ser Ser Leu Leu 
385                 390                 395                 400 


Lys Gln His Met Asp Leu Leu Lys Ala Ala Val Phe Pro Leu Lys His 
                405                 410                 415     


Pro Leu Ile Glu Pro Gly Ser Leu Phe Asn Lys Asp Gly Asp Ala Asp 
            420                 425                 430         


Glu Phe Val Asp Val His Met Pro Asp Val His Lys Leu Val Ser Asp 
        435                 440                 445             


Val Asp Leu Gly Leu Pro Asp Trp Ser Leu Tyr Ala Leu Ile Gly Ala 
    450                 455                 460                 


Thr Ile Ile Ala Phe Phe Ile Leu Ile Cys Leu Ile Arg Ile Cys Cys 
465                 470                 475                 480 


Lys Lys Gly Gly Arg Arg Asn Ser Pro Thr Asn Arg Pro Asp Leu Pro 
                485                 490                 495     


Ile Gly Leu Ser Thr Thr Pro Gln Pro Lys Ser Lys Val Ile Ser Ser 
            500                 505                 510         


Trp Glu Ser Tyr Lys Gly Thr Ser Asn Val 
        515                 520         


<210>  525
<211>  525
<212>  PRT
<213>  Lleida bat lyssavirus

<400>  525

Met Ala Tyr Gln Val Thr Leu Ile Leu Asn Ser Leu Ser Phe Ile Thr 
1               5                   10                  15      


Gly Gln Asp Ile Phe Pro Leu Tyr Thr Ile Pro Asp Ser Ile Gly Pro 
            20                  25                  30          


Trp Thr Pro Ile Asp Leu Ser His Leu Lys Cys Pro Asp Asn Ala Phe 
        35                  40                  45              


Ile Val Asp Glu Asn Cys Thr Asp His Gly Glu Ile Asn Tyr Ser Glu 
    50                  55                  60                  


Leu Lys Pro Ser Phe His Ser Gln Ser Lys Val Pro Gly Phe Thr Cys 
65                  70                  75                  80  


Thr Gly Ile Val Thr Gln Ala Val Thr Tyr Thr Asn Phe Leu Gly Tyr 
                85                  90                  95      


Val Ser Thr Thr Phe Gln Arg Ser His Phe Val Pro Asn Pro Arg Glu 
            100                 105                 110         


Cys Arg Ala Ala Gln Glu Trp Lys Ser Lys Gly Asp Pro Arg Tyr Glu 
        115                 120                 125             


Asp Ser Leu Gln Asn Pro Tyr Pro Asp Ser Lys Trp Leu Arg Thr Val 
    130                 135                 140                 


Thr Thr Thr Arg Glu Ser Leu Leu Ile Ile Glu Pro Ala Ile Ala Glu 
145                 150                 155                 160 


Met Asp Ile Tyr Asn Lys Thr Met Phe Ser Ser Val Phe Arg Gly Gly 
                165                 170                 175     


Leu Cys Asp Phe Ser Arg Gly Asn Pro Asp Tyr Cys Glu Thr Ser His 
            180                 185                 190         


Ser Tyr Ser Ile Trp Met Pro Tyr Glu Glu Ser Arg Gly Ile Thr Cys 
        195                 200                 205             


Asp Ile Phe Gln Ser Ser Thr Gly Arg Leu Phe Lys Lys Asp Asp Gln 
    210                 215                 220                 


Val Cys Gly Ile Gln Asp Glu Arg Gly Met Phe Lys Ser Thr Arg Gly 
225                 230                 235                 240 


Ala Cys Lys Met Thr Ile Cys Gly Lys Ser Gly Val Arg Leu Tyr Asp 
                245                 250                 255     


Gly Thr Trp Ile Ser Tyr Asn Thr Ile Asp Asn Leu Lys Val Cys Pro 
            260                 265                 270         


Arg Ser Ala Met Val Asn Met His Thr Thr Lys Leu Asp Ala Leu Glu 
        275                 280                 285             


Glu Ala Val Val Arg Asp Leu Val Lys Lys Arg Glu Glu Cys Leu Asn 
    290                 295                 300                 


Ala Phe Glu Glu Ile Ile Ile Thr Asn Ser Ile Ser Phe Arg Lys Met 
305                 310                 315                 320 


Ser Leu Phe Arg Lys Met Val Pro Gly Ser Gly Leu Val Tyr Thr Met 
                325                 330                 335     


Ile Asn Lys Thr Leu Met Glu Ala His Gly His Tyr Lys Ser Val Ser 
            340                 345                 350         


Asn Trp Ser Glu Ile Leu Pro Thr Pro Ile Cys Leu Leu Val Lys Gly 
        355                 360                 365             


Lys Cys Tyr Gln Asp His Asp Gly Val Leu Phe Asn Gly Ile Val Lys 
    370                 375                 380                 


Asp His Arg Gly Lys Val Leu Ile Pro Glu Met Gln Ser His Leu Leu 
385                 390                 395                 400 


Gln Asp His Phe Glu Leu Leu Arg Ser Asn Thr Ile Pro Trp Arg His 
                405                 410                 415     


Pro Leu Val His Tyr Pro Asp Asp Thr Asp Pro Ser Ser Glu Thr Ala 
            420                 425                 430         


Glu Phe Ile Gln Leu His Met Arg Asp Pro Ala Lys Val Thr Ser Asp 
        435                 440                 445             


Ile Asp Phe Gly Leu Ser Ser Trp Lys Arg Tyr Leu Ile Phe Val Ala 
    450                 455                 460                 


Cys Leu Ile Leu Gly Leu Leu Ile Leu Trp Val Val Ile Lys Tyr Ser 
465                 470                 475                 480 


Phe Lys Val Tyr Arg Val Met Thr Lys Lys Arg Ser Ser Arg Arg Lys 
                485                 490                 495     


Met Gln Asp Ile Leu Pro Asp Pro Val Ile Arg Ser Val Gly Gly Asn 
            500                 505                 510         


Gln Leu Ser Trp Glu Ser Tyr Lys Asn Ser Thr Asn Leu 
        515                 520                 525 


<210>  526
<211>  522
<212>  PRT
<213>  Mokola lyssavirus

<400>  526

Met Asn Ile Pro Cys Phe Val Val Ile Leu Ser Leu Ala Thr Thr His 
1               5                   10                  15      


Ser Leu Gly Glu Phe Pro Leu Tyr Thr Ile Pro Glu Lys Ile Glu Lys 
            20                  25                  30          


Trp Thr Pro Ile Asp Met Ile His Leu Ser Cys Pro Asn Asn Leu Leu 
        35                  40                  45              


Ser Glu Glu Glu Gly Cys Asn Ala Glu Ser Ser Phe Thr Tyr Phe Glu 
    50                  55                  60                  


Leu Lys Ser Gly Tyr Leu Ala His Gln Lys Val Pro Gly Phe Thr Cys 
65                  70                  75                  80  


Thr Gly Val Val Asn Glu Ala Glu Thr Tyr Thr Asn Phe Val Gly Tyr 
                85                  90                  95      


Val Thr Thr Thr Phe Lys Arg Lys His Phe Arg Pro Thr Val Ala Ala 
            100                 105                 110         


Cys Arg Asp Ala Tyr Asn Trp Lys Val Ser Gly Asp Pro Arg Tyr Glu 
        115                 120                 125             


Glu Ser Leu His Thr Pro Tyr Pro Asp Ser Ser Trp Leu Arg Thr Val 
    130                 135                 140                 


Thr Thr Thr Lys Glu Ser Leu Leu Ile Ile Ser Pro Ser Ile Val Glu 
145                 150                 155                 160 


Met Asp Ile Tyr Gly Arg Thr Leu His Ser Pro Met Phe Pro Ser Gly 
                165                 170                 175     


Val Cys Ser Asn Val Tyr Pro Ser Val Pro Ser Cys Glu Thr Asn His 
            180                 185                 190         


Asp Tyr Thr Leu Trp Leu Pro Glu Asp Pro Ser Leu Ser Leu Val Cys 
        195                 200                 205             


Asp Ile Phe Thr Ser Ser Asn Gly Lys Lys Ala Met Asn Gly Ser Arg 
    210                 215                 220                 


Ile Cys Gly Phe Lys Asp Glu Arg Gly Phe Tyr Arg Ser Leu Lys Gly 
225                 230                 235                 240 


Ala Cys Lys Leu Thr Leu Cys Gly Arg Pro Gly Ile Arg Leu Phe Asp 
                245                 250                 255     


Gly Thr Trp Val Ser Phe Thr Lys Pro Asp Val His Val Trp Cys Thr 
            260                 265                 270         


Pro Asn Gln Leu Ile Asn Ile His Asn Asp Arg Leu Asp Glu Ile Glu 
        275                 280                 285             


His Leu Ile Val Glu Asp Ile Ile Lys Lys Arg Glu Glu Cys Leu Asp 
    290                 295                 300                 


Thr Leu Glu Thr Ile Leu Met Ser Gln Ser Val Ser Phe Arg Arg Leu 
305                 310                 315                 320 


Ser His Phe Arg Lys Leu Val Pro Gly Tyr Gly Lys Ala Tyr Thr Ile 
                325                 330                 335     


Leu Asn Gly Ser Leu Met Glu Thr Asn Val Tyr Tyr Lys Arg Val Asp 
            340                 345                 350         


Lys Trp Ala Asp Ile Leu Pro Ser Lys Gly Cys Leu Lys Val Gly Gln 
        355                 360                 365             


Gln Cys Met Glu Pro Val Lys Gly Val Leu Phe Asn Gly Ile Ile Lys 
    370                 375                 380                 


Gly Pro Asp Gly Gln Ile Leu Ile Pro Glu Met Gln Ser Glu Gln Leu 
385                 390                 395                 400 


Lys Gln His Met Asp Leu Leu Lys Ala Ala Val Phe Pro Leu Arg His 
                405                 410                 415     


Pro Leu Ile Ser Arg Glu Ala Val Phe Lys Lys Asp Gly Asp Ala Asp 
            420                 425                 430         


Asp Phe Val Asp Leu His Met Pro Asp Val His Lys Ser Val Ser Asp 
        435                 440                 445             


Val Asp Leu Gly Leu Pro His Trp Gly Phe Trp Met Leu Ile Gly Ala 
    450                 455                 460                 


Thr Ile Val Ala Phe Val Val Leu Val Cys Leu Leu Arg Val Cys Cys 
465                 470                 475                 480 


Lys Arg Val Arg Arg Arg Arg Ser Gly Arg Ala Thr Gln Glu Ile Pro 
                485                 490                 495     


Leu Ser Phe Pro Ser Ala Pro Val Pro Arg Ala Lys Val Val Ser Ser 
            500                 505                 510         


Trp Glu Ser Tyr Lys Gly Leu Pro Gly Thr 
        515                 520         


<210>  527
<211>  524
<212>  PRT
<213>  Rabies lyssavirus

<400>  527

Met Val Pro Gln Ala Leu Leu Phe Val Pro Leu Leu Val Phe Pro Leu 
1               5                   10                  15      


Cys Phe Gly Lys Phe Pro Ile Tyr Thr Ile Pro Asp Lys Leu Gly Pro 
            20                  25                  30          


Trp Ser Pro Ile Asp Ile His His Leu Ser Cys Pro Asn Asn Leu Val 
        35                  40                  45              


Val Glu Asp Glu Gly Cys Thr Asn Leu Ser Gly Phe Ser Tyr Met Glu 
    50                  55                  60                  


Leu Lys Val Gly Tyr Ile Leu Ala Ile Lys Val Asn Gly Phe Thr Cys 
65                  70                  75                  80  


Thr Gly Val Val Thr Glu Ala Glu Thr Tyr Thr Asn Phe Val Gly Tyr 
                85                  90                  95      


Val Thr Thr Thr Phe Lys Arg Lys His Phe Arg Pro Thr Pro Asp Ala 
            100                 105                 110         


Cys Arg Ala Ala Tyr Asn Trp Lys Met Ala Gly Asp Pro Arg Tyr Glu 
        115                 120                 125             


Glu Ser Leu His Asn Pro Tyr Pro Asp Tyr Arg Trp Leu Arg Thr Val 
    130                 135                 140                 


Lys Thr Thr Lys Glu Ser Leu Val Ile Ile Ser Pro Ser Val Ala Asp 
145                 150                 155                 160 


Leu Asp Pro Tyr Asp Arg Ser Leu His Ser Arg Val Phe Pro Ser Gly 
                165                 170                 175     


Lys Cys Ser Gly Val Ala Val Ser Ser Thr Tyr Cys Ser Thr Asn His 
            180                 185                 190         


Asp Tyr Thr Ile Trp Met Pro Glu Asn Pro Arg Leu Gly Met Ser Cys 
        195                 200                 205             


Asp Ile Phe Thr Asn Ser Arg Gly Lys Arg Ala Ser Lys Gly Ser Glu 
    210                 215                 220                 


Thr Cys Gly Phe Val Asp Glu Arg Gly Leu Tyr Lys Ser Leu Lys Gly 
225                 230                 235                 240 


Ala Cys Lys Leu Lys Leu Cys Gly Val Leu Gly Leu Arg Leu Met Asp 
                245                 250                 255     


Gly Thr Trp Val Ser Met Gln Thr Ser Asn Glu Thr Lys Trp Cys Pro 
            260                 265                 270         


Pro Asp Lys Leu Val Asn Leu His Asp Phe Arg Ser Asp Glu Ile Glu 
        275                 280                 285             


His Leu Val Val Glu Glu Leu Val Arg Lys Arg Glu Glu Cys Leu Asp 
    290                 295                 300                 


Ala Leu Glu Ser Ile Met Thr Thr Lys Ser Val Ser Phe Arg Arg Leu 
305                 310                 315                 320 


Ser His Leu Arg Lys Leu Val Pro Gly Phe Gly Lys Ala Tyr Thr Ile 
                325                 330                 335     


Phe Asn Lys Thr Leu Met Glu Ala Asp Ala His Tyr Lys Ser Val Arg 
            340                 345                 350         


Thr Trp Asn Glu Ile Leu Pro Ser Lys Gly Cys Leu Arg Val Gly Gly 
        355                 360                 365             


Arg Cys His Pro His Val Asn Gly Val Phe Phe Asn Gly Ile Ile Leu 
    370                 375                 380                 


Gly Pro Asp Gly Asn Val Leu Ile Pro Glu Met Gln Ser Ser Leu Leu 
385                 390                 395                 400 


Gln Gln His Met Glu Leu Leu Glu Ser Ser Val Ile Pro Leu Val His 
                405                 410                 415     


Pro Leu Ala Asp Pro Ser Thr Val Phe Lys Asp Gly Asp Glu Ala Glu 
            420                 425                 430         


Asp Phe Val Glu Val His Leu Pro Asp Val His Asn Gln Val Ser Gly 
        435                 440                 445             


Val Asp Leu Gly Leu Pro Asn Trp Gly Lys Tyr Val Leu Leu Ser Ala 
    450                 455                 460                 


Gly Ala Leu Thr Ala Leu Met Leu Ile Ile Phe Leu Met Thr Cys Cys 
465                 470                 475                 480 


Arg Arg Val Asn Arg Ser Glu Pro Thr Gln His Asn Leu Arg Gly Thr 
                485                 490                 495     


Gly Arg Glu Val Ser Val Thr Pro Gln Ser Gly Lys Ile Ile Ser Ser 
            500                 505                 510         


Trp Glu Ser His Lys Ser Gly Gly Glu Thr Arg Leu 
        515                 520                 


<210>  528
<211>  522
<212>  PRT
<213>  Shimoni bat lyssavirus

<400>  528

Met Ser Asn Leu Cys Thr Ile Phe Ile Leu Cys Ala Ser Ile Met Val 
1               5                   10                  15      


Ser Leu Gly Asp Phe Pro Leu Tyr Thr Ile Pro Glu Lys Ile Gly Pro 
            20                  25                  30          


Trp Thr Pro Ile Asp Leu Thr His Leu Ser Cys Pro Asn Asn Leu Leu 
        35                  40                  45              


Ser Glu Asp Asp Gly Cys Ser Ser Ser Ser Thr Phe Ser Tyr Ile Glu 
    50                  55                  60                  


Leu Arg Thr Gly Tyr Leu Thr His Gln Lys Val Ser Gly Phe Thr Cys 
65                  70                  75                  80  


Thr Gly Val Ile Asn Glu Ala Val Thr Tyr Thr Asn Phe Val Gly Tyr 
                85                  90                  95      


Val Thr Thr Thr Phe Lys Arg Lys His Phe Lys Pro Thr Ala Ser Ala 
            100                 105                 110         


Cys Arg Asp Ala Tyr His Trp Lys Ile Ser Gly Asp Pro Arg Tyr Glu 
        115                 120                 125             


Glu Ser Leu His Thr Pro Tyr Pro Asp Asn Ser Trp Leu Arg Thr Val 
    130                 135                 140                 


Thr Thr Thr Lys Glu Ser Leu Leu Ile Ile Ser Pro Ser Ile Val Glu 
145                 150                 155                 160 


Met Asp Ile Tyr Ser Arg Ser Leu His Ser Pro Met Phe Pro Thr Gly 
                165                 170                 175     


Arg Cys Tyr Asp Phe Tyr Lys Ser Thr Pro Ser Cys Leu Thr Asn His 
            180                 185                 190         


Asp Tyr Thr Ile Trp Leu Pro Asp Asp Ala Asn Val Arg Leu Thr Cys 
        195                 200                 205             


Asp Ile Phe Val Thr Ser Thr Gly Lys Lys Ser Met Asn Gly Ser Lys 
    210                 215                 220                 


Met Cys Gly Phe Thr Asp Glu Arg Gly Leu Tyr Arg Thr Leu Lys Gly 
225                 230                 235                 240 


Ala Cys Lys Leu Thr Leu Cys Gly Lys Pro Gly Leu Arg Leu Phe Asp 
                245                 250                 255     


Gly Thr Trp Ile Ser Ile Thr Arg Pro Glu Ile Val Met Trp Cys Ser 
            260                 265                 270         


Pro Asn Gln Leu Val Asn Val His Asn Asn Arg Val Asp Glu Ile Glu 
        275                 280                 285             


His Leu Ile Val Gly Asp Leu Ile Arg Arg Arg Glu Glu Cys Leu Asp 
    290                 295                 300                 


Thr Leu Glu Thr Val Leu Met Ser Lys Ser Val Ser Phe Arg Arg Leu 
305                 310                 315                 320 


Ser His Phe Arg Lys Leu Val Pro Gly Phe Gly Lys Ala Tyr Thr Ile 
                325                 330                 335     


Ala Asn Gly Ser Leu Met Glu Thr Asn Val His Tyr Lys Arg Val Asp 
            340                 345                 350         


Arg Trp Glu Glu Ile Leu Pro Ser Lys Gly Cys Leu Lys Leu Asn Asp 
        355                 360                 365             


Lys Cys Leu Asn Pro Glu Asn Gly Val Phe Phe Asn Gly Ile Ile Lys 
    370                 375                 380                 


Gly Pro Asp Gly Gln Val Leu Ile Pro Glu Met Gln Ser Ser Leu Leu 
385                 390                 395                 400 


Lys Gln His Met Asp Leu Leu Lys Ala Ser Val Phe Pro Leu Arg His 
                405                 410                 415     


Pro Leu Ile Asp Gln Thr Ser Ile Phe Lys Lys Asp Gly Glu Ala Asp 
            420                 425                 430         


Asp Phe Val Asp Val His Met Pro Asp Pro His Lys Ser Ile Ser Asn 
        435                 440                 445             


Ile Asp Leu Gly Leu Pro Asp Trp Gly Leu Tyr Ala Met Ile Gly Gly 
    450                 455                 460                 


Thr Val Val Ala Phe Leu Ile Leu Val Cys Leu Leu Cys Thr Cys Cys 
465                 470                 475                 480 


Lys Arg Arg Arg Arg Arg Asn Ser Arg Lys Pro Ser Ser Glu Gln Thr 
                485                 490                 495     


Pro Lys Ile Ser Ser Thr Pro Pro Ser Gly Thr Lys Val Ile Ser Ser 
            500                 505                 510         


Trp Glu Ser Tyr Lys Gly Thr Ser Ser Val 
        515                 520         


<210>  529
<211>  542
<212>  PRT
<213>  Taiwan bat lyssavirus

<400>  529

Met Pro Asn Tyr Thr Leu Leu Ile Thr Leu Leu Leu Ser Tyr Ser Tyr 
1               5                   10                  15      


Cys Ser Gly Tyr Phe Pro Ile Tyr Thr Ile Pro Asp Lys Ile Gly Pro 
            20                  25                  30          


Trp Ser Pro Ile Asp Ile Arg Asp Leu Ser Cys Pro Asn Asn Leu Leu 
        35                  40                  45              


Val Glu Asp Glu Gly Cys Asn Thr Leu Ser Ser Phe Ser Tyr Met Glu 
    50                  55                  60                  


Leu Lys Ile Gly Tyr Ile Lys Ala Ile Lys Val Glu Gly Phe Thr Cys 
65                  70                  75                  80  


Thr Gly Val Ile Thr Glu Ala Glu Thr Tyr Thr Asn Leu Ile Gly Tyr 
                85                  90                  95      


Val Thr Thr Thr Phe Lys Arg Lys His Phe Arg Pro Thr Met Ser Gly 
            100                 105                 110         


Cys Arg Asp Ala Tyr Arg Trp Lys Ile Thr Gly Asp Pro Arg Tyr Glu 
        115                 120                 125             


Glu Ser Leu His Asn Pro Tyr Pro Asp Ser Ser Trp Leu Arg Thr Val 
    130                 135                 140                 


Thr Thr Ser Lys Glu Ser Leu Leu Ile Ile Ser Pro Ser Val Ala Asp 
145                 150                 155                 160 


Met Asp Ala Tyr Asp Lys Gln Leu Tyr Ala Pro Ile Phe Pro Asp Gly 
                165                 170                 175     


Lys Cys Thr Asn Leu Leu Pro Gly Ala Phe Tyr Cys Ser Thr Asn His 
            180                 185                 190         


Glu Tyr Thr Ile Trp Met Pro Lys Asp Pro Arg Leu Asn Leu Ala Cys 
        195                 200                 205             


Asp Ile Phe Val Asn Ser Lys Gly Lys Met Ala Met Lys Asp Gly Gln 
    210                 215                 220                 


Val Cys Gly Phe Ile Asp Glu Arg Gly Leu Tyr Lys Ser Leu Lys Gly 
225                 230                 235                 240 


Ala Cys Lys Leu Lys Leu Cys Gly Ile Ser Gly Ile Arg Leu Val Asp 
                245                 250                 255     


Gly Ser Trp Val Ser Ile Gln Arg Lys Asn Pro Pro Lys Pro Cys Ser 
            260                 265                 270         


Pro Gly Gln Leu Val Asn Ile His Asp Phe Arg Thr Glu Glu Ile Glu 
        275                 280                 285             


His Leu Ile Val Glu Asp Leu Val Lys Lys Arg Glu Glu Cys Leu Asp 
    290                 295                 300                 


Ala Leu Glu Thr Ile Met Ser Thr Lys Thr Ile Ser Phe Arg Lys Leu 
305                 310                 315                 320 


Ser His Phe Arg Lys Leu Val Pro Gly Phe Gly Lys Ala Tyr Thr Leu 
                325                 330                 335     


Ile Asn Lys Thr Leu Met Glu Ala Asp Ala His Tyr Arg Ser Ile Arg 
            340                 345                 350         


Asn Trp Thr Glu Val Ile Pro Ser Lys Gly Cys Leu Arg Ile Gly Gly 
        355                 360                 365             


Tyr Cys His Pro His Tyr Asp Gly Ile Phe Phe Asn Gly Ile Ile Leu 
    370                 375                 380                 


Ser Pro Gln Gly Asp Val Leu Ile Pro Glu Met Gln Ser Ala Leu Leu 
385                 390                 395                 400 


Gln Gln His Val Glu Leu Leu Glu Ser Ser Val Ile Pro Leu Arg His 
                405                 410                 415     


Pro Leu Ala Asp Pro Ser Ala Thr Leu Arg Glu Ser Asn Glu Val Glu 
            420                 425                 430         


Asp Phe Val Glu Ile His Leu Pro Ala Val Gln Lys His Val Ser Asp 
        435                 440                 445             


Ile Ser Leu Gly Leu Pro Glu Trp Lys His Tyr Phe Tyr Ile Ile Ala 
    450                 455                 460                 


Ser Leu Leu Ala Phe Leu Ala Phe Ala Ile Leu Ala Ala Met Phe Cys 
465                 470                 475                 480 


Arg Arg Phe Lys Arg Arg Lys Lys Pro Arg Pro Asn Ser Val Glu Leu 
                485                 490                 495     


Val Arg Arg Thr Ser Val Thr Ser Val Ser Gly Arg Pro Val His Ser 
            500                 505                 510         


Trp Glu Ser Tyr Lys Thr Gly Gln Gln Val Ala Pro Glu Phe Val Pro 
        515                 520                 525             


Pro Pro His Asp Thr Pro Asn Ser Pro Ser Arg Ile His Thr 
    530                 535                 540         


<210>  530
<211>  525
<212>  PRT
<213>  West Caucasian bat lyssavirus

<400>  530

Met Ala Ser Tyr Phe Ala Leu Val Leu Asn Gly Ile Ser Met Val Phe 
1               5                   10                  15      


Ser Gln Gly Leu Phe Pro Leu Tyr Thr Ile Pro Asp His Leu Gly Pro 
            20                  25                  30          


Trp Thr Pro Ile Asp Leu Ser His Leu His Cys Pro Asn Asn Leu Tyr 
        35                  40                  45              


Thr Asp Ala Ser Tyr Cys Thr Thr Glu Gln Ser Ile Thr Tyr Thr Glu 
    50                  55                  60                  


Leu Lys Val Gly Ser Ser Val Ser Gln Lys Ile Pro Gly Phe Thr Cys 
65                  70                  75                  80  


Thr Gly Val Arg Thr Glu Ser Val Thr Tyr Thr Asn Phe Val Gly Tyr 
                85                  90                  95      


Val Thr Thr Thr Phe Lys Lys Lys His Phe Pro Pro Lys Ser Arg Asp 
            100                 105                 110         


Cys Arg Glu Ala Tyr Glu Arg Lys Lys Ala Gly Asp Pro Arg Tyr Glu 
        115                 120                 125             


Glu Ser Leu Ala His Pro Tyr Pro Asp Asn Ser Trp Leu Arg Thr Val 
    130                 135                 140                 


Thr Thr Thr Lys Asp Ser Trp Val Ile Ile Glu Pro Ser Val Val Glu 
145                 150                 155                 160 


Leu Asp Ile Tyr Thr Ser Ala Leu Tyr Ser Pro Leu Phe Lys Asp Gly 
                165                 170                 175     


Thr Cys Ser Lys Ser Arg Thr Tyr Ser Pro Tyr Cys Pro Thr Asn His 
            180                 185                 190         


Asp Phe Thr Ile Trp Met Pro Glu Ser Glu Asn Ile Arg Ser Ala Cys 
        195                 200                 205             


Asn Leu Phe Ser Thr Ser Arg Gly Lys Leu Val Arg Asn Arg Thr Ser 
    210                 215                 220                 


Thr Cys Gly Ile Ile Asp Glu Arg Gly Leu Phe Arg Ser Val Lys Gly 
225                 230                 235                 240 


Ala Cys Lys Ile Ser Ile Cys Gly Arg Gln Gly Ile Arg Leu Val Asp 
                245                 250                 255     


Gly Thr Trp Met Ser Phe Arg Tyr Ser Glu Tyr Leu Pro Val Cys Ser 
            260                 265                 270         


Pro Ser Gln Leu Ile Asn Thr His Asp Ile Lys Val Asp Glu Leu Glu 
        275                 280                 285             


Asn Ala Ile Val Leu Asp Leu Ile Arg Arg Arg Glu Glu Cys Leu Asp 
    290                 295                 300                 


Thr Leu Glu Thr Ile Leu Met Ser Gly Ser Val Ser His Arg Arg Leu 
305                 310                 315                 320 


Ser His Phe Arg Lys Leu Val Pro Gly Ser Gly Lys Ala Tyr Ser Tyr 
                325                 330                 335     


Ile Asn Gly Thr Leu Met Glu Ser Asp Ala His Tyr Ile Lys Val Glu 
            340                 345                 350         


Asn Trp Ser Glu Val Ile Pro His Lys Gly Cys Leu Met Val Gly Gly 
        355                 360                 365             


Lys Cys Tyr Glu Pro Val Asn Asp Val Tyr Phe Asn Gly Ile Ile Arg 
    370                 375                 380                 


Asp Ser Asn Asn Gln Ile Leu Ile Pro Glu Met Gln Ser Ser Leu Leu 
385                 390                 395                 400 


Arg Glu His Val Asp Leu Leu Lys Ala Asn Ile Val Pro Phe Arg His 
                405                 410                 415     


Pro Met Leu Leu Arg Ser Phe Thr Ser Asp Thr Glu Glu Asp Ile Val 
            420                 425                 430         


Glu Phe Val Asn Pro His Leu Gln Asp Thr Gln Lys Leu Val Ser Asp 
        435                 440                 445             


Met Asp Leu Gly Leu Ser Asp Trp Lys Arg Tyr Leu Leu Ile Gly Ser 
    450                 455                 460                 


Leu Ala Val Gly Gly Val Val Ala Ile Leu Phe Ile Gly Thr Cys Cys 
465                 470                 475                 480 


Leu Arg Cys Arg Ala Gly Arg Asn Arg Arg Thr Ile Arg Ser Asn His 
                485                 490                 495     


Arg Ser Leu Ser His Asp Val Val Phe His Lys Asp Lys Asp Lys Val 
            500                 505                 510         


Ile Thr Ser Trp Glu Ser Tyr Lys Gly Gln Thr Ala Gln 
        515                 520                 525 


<210>  531
<211>  522
<212>  PRT
<213>  Culex ohlsrhavirus

<400>  531

Met Ser Val Arg Thr His Ile Val Phe Lys Leu Phe Leu Ile Thr Ser 
1               5                   10                  15      


Tyr Val Gly Glu Asn Ile Leu Ala Leu Gly Pro Asp Asn Leu Met Ile 
            20                  25                  30          


Leu Phe Pro Thr Ser Thr Asn Ile Glu Trp His Asp Val Ser Pro Ser 
        35                  40                  45              


Asn Leu Ile Cys Pro Gly Ala Ser Leu His Gln Lys Met Asp Lys Gly 
    50                  55                  60                  


Leu Tyr Leu Pro Val Arg Arg Pro Thr Ile Gly Lys Thr Pro Asn Leu 
65                  70                  75                  80  


Ser Gly Thr Leu Cys Ile Ala Met Glu Leu Val Thr Thr Cys Tyr Lys 
                85                  90                  95      


Gly Phe Phe Gly Ser Val Asp Val Thr Ile Ser Ser Asn Pro Ser Val 
            100                 105                 110         


Ile Ser Glu Asp Asp Cys Arg Lys Glu Ile Ala Ser Gln Ser Gln Gly 
        115                 120                 125             


Asp Tyr Arg Ser Thr Glu His Pro Gln Pro Ser Cys Ser Trp Met Arg 
    130                 135                 140                 


Thr Ser Ser Val Arg Arg Ser Ile Ile Thr Leu Asn Pro Leu Asp Val 
145                 150                 155                 160 


His Tyr Asp Pro Tyr Ser Asp Thr Leu Tyr Ser Ser Ile Phe Leu Gly 
                165                 170                 175     


Gly Lys Cys Gln Thr Asp Val Cys Pro Thr Val Phe Glu Asn Arg Ile 
            180                 185                 190         


Trp Ile Pro His Glu Ser Leu Thr Glu Phe Cys Ser Ala Glu Lys Leu 
        195                 200                 205             


Ser Glu Ser Lys Ile Ile Leu Tyr Asn Ser Ser Asp Thr Gln Ser Ser 
    210                 215                 220                 


Phe Trp Ser Pro Asp Phe Val Ile Pro Asp Asp Lys Thr Pro Cys Ile 
225                 230                 235                 240 


Met Asp Phe Cys Gly His Lys Gly Leu Arg Phe Pro Ser Gly Asp Trp 
                245                 250                 255     


Val Ala Leu Ser Arg Asp Asp Ile Pro Lys Glu Glu Trp Val Gly Glu 
            260                 265                 270         


Tyr Phe Tyr His Leu Thr Asp Cys Ala Pro His Thr Val Val Asn Val 
        275                 280                 285             


Val Asp Ser Gly Gln Asp Phe Asn Tyr Ile Ser Glu Thr Leu Leu Asp 
    290                 295                 300                 


Glu Phe Ile Asn Glu Gln Cys Glu Leu Thr Ile Ser Lys Ile Lys Glu 
305                 310                 315                 320 


Gly Asp Leu Ile Ser Arg Ile Glu Leu Gln Thr Leu Ser Pro Arg Thr 
                325                 330                 335     


Pro Gly Phe His Pro Val Tyr Arg Tyr Gln Pro Gly Thr Phe Gln Met 
            340                 345                 350         


Ser Met Thr His Tyr Ser Trp Ile Val Ile Lys Pro Thr Asp Val Phe 
        355                 360                 365             


Pro Tyr Ile Glu Leu Phe Ser His Ser Asn Glu Ser Ile Arg Tyr Asp 
    370                 375                 380                 


Tyr Trp Thr Val Asp Asn Lys Thr Gly Ile Ile Asp Gly Pro Asn Gly 
385                 390                 395                 400 


Leu Tyr Val Leu Asn Lys Asn Leu Ile Tyr Gly Leu Arg Glu Glu Gln 
                405                 410                 415     


Thr Phe Lys Arg Ile Leu Ser Lys Ser Ser Lys Gln Lys Phe Pro Leu 
            420                 425                 430         


Phe Asn Thr Lys Ile Ser Gln Pro Leu Ser Val Ile Lys Leu Leu Ser 
        435                 440                 445             


Tyr Ser Ser His Ser Phe Ser Asn Asp Ala Thr Leu Ala Glu Val Leu 
    450                 455                 460                 


Trp His Pro Leu Leu Ile Gly Met Val Leu Thr Cys Ala Cys Gly Leu 
465                 470                 475                 480 


Leu Val Leu Val Met Ile Val Tyr Phe Lys Arg Asn Leu Val Leu Arg 
                485                 490                 495     


Lys Val Leu Ser Cys Met Lys Glu Ser Thr Lys Ser Thr Asp Asp Met 
            500                 505                 510         


Ser Glu Glu Glu Gly Asp Tyr Phe Asp Pro 
        515                 520         


<210>  532
<211>  517
<212>  PRT
<213>  Ohlsdorf ohlsrhavirus

<400>  532

Met Val Asn Tyr Val Lys Phe Pro Leu Leu Asn Met Val Ser Tyr Phe 
1               5                   10                  15      


Ile Trp Tyr Ser Pro Asp Val Leu Cys Gln Ser Ile Leu Phe Pro Thr 
            20                  25                  30          


Thr Asn Thr Ile Asp Trp Ile Pro Leu Asp Pro Asn Asp Ile Ser Cys 
        35                  40                  45              


Asp Phe Pro Tyr Tyr Pro Ser Glu Ser Asn Ser Asn Leu Lys Ile Arg 
    50                  55                  60                  


Gly Arg Ser Pro Ile Leu Gln Thr Lys Tyr Glu Ile Asn Gly Phe Leu 
65                  70                  75                  80  


Cys Asn Ala Ile Thr Thr Val Thr Ser Cys Asp Lys Gly Phe Phe Gly 
                85                  90                  95      


Gly Glu Thr Val Thr His Ser Glu Tyr Arg Pro Pro Leu Glu Phe Lys 
            100                 105                 110         


Asp Cys Glu Asn Ala Ile Arg Lys Phe Lys Ser Gly Thr Leu Asp Thr 
        115                 120                 125             


Tyr Glu His Pro Pro Pro Ser Cys Ser Trp Met Lys Lys Ser Asp Asn 
    130                 135                 140                 


Leu Lys Ser Thr Val Leu Val Gln Glu Arg Thr Val Leu Phe Asp Pro 
145                 150                 155                 160 


Tyr Ser Asn Gln Leu Ile Ser Ser Trp Phe Ala Asp Gly Lys Cys Glu 
                165                 170                 175     


Tyr Ser Pro Cys Ser Thr Val Lys Gln Asn Met Lys Trp Ile Ser Asp 
            180                 185                 190         


Val Asn His Pro Pro Glu Cys Ile Ser Asp His Leu Asp Glu Val Ile 
        195                 200                 205             


Met Phe Leu Thr Asp Ser Lys Ser Thr Asn Ser Tyr Thr Ile Trp Ser 
    210                 215                 220                 


Pro Asp Ile His Ile Thr Asp Phe Asn Glu Ile Cys Thr Met Thr Tyr 
225                 230                 235                 240 


Cys Ser Val Asn Gly Phe Leu Phe Pro Asn Gly Glu Trp Val Gly Ile 
                245                 250                 255     


Asn Lys Asn Asp Ile Pro Ser Ile Pro Lys Leu Gly Glu Phe Leu Tyr 
            260                 265                 270         


Asn Ile Lys Glu Cys Asn Ser Ser Thr His Leu His Ile Lys Glu His 
        275                 280                 285             


Arg Tyr Ile Asn Arg Glu Thr Glu Gln Thr Glu Phe Ser Ile Leu Leu 
    290                 295                 300                 


Ser Val Glu Cys Ser Lys Thr Lys Asp Asp Leu Leu Ser Gln Thr Ser 
305                 310                 315                 320 


Ile Asn Arg Val Gln Leu Gln Ser Leu Thr Pro Arg Ile Pro Gly Arg 
                325                 330                 335     


His Arg Val Tyr Arg Phe His Asn Asn Thr Leu Gln Met Gly Tyr Ser 
            340                 345                 350         


Glu Tyr Lys Trp Val Arg Thr Glu Lys Ser Val Thr Phe Pro Phe Ile 
        355                 360                 365             


Lys Ile Ile Leu Ala Asn Gly Lys Glu Val Arg Trp Pro Tyr Trp Tyr 
    370                 375                 380                 


Leu Asp Pro Asn Asn Asp Ile Ile Glu Gly Pro Asn Gly Leu Phe Ile 
385                 390                 395                 400 


Lys Asn Lys Lys Leu Ala Tyr Ala Leu Ser Asp Leu Ile Asn Tyr Asn 
                405                 410                 415     


Arg Ser Ile Leu Ile Asn Gly Lys Ile Ser Tyr Asp Ile Pro His Val 
            420                 425                 430         


His Leu Pro Lys Val Ser Pro Ile Asn Asn Ile Ile Ser Thr Arg Asp 
        435                 440                 445             


Phe Asn Thr Ile Asn Asp Asp Asn Leu Ile Ser Val Ile Arg Gly Trp 
    450                 455                 460                 


Ser Pro Phe His Thr Ile Thr Gln Ser Ile Phe Trp Leu Ser Ala Ile 
465                 470                 475                 480 


Val Met Val Ile Leu Ile Leu Lys Tyr Thr Val Pro Leu Leu Ile Asn 
                485                 490                 495     


Lys Ile Lys Asn Arg Arg Lys Ser Ile Asp Gln Asp Thr Glu Leu Ser 
            500                 505                 510         


Val Phe Tyr Lys Pro 
        515         


<210>  533
<211>  531
<212>  PRT
<213>  Anguillid perhabdovirus

<400>  533

Met Asp Thr Leu Ile Lys Ile Leu Leu Ile Ile Val Ile Leu Lys Ser 
1               5                   10                  15      


Leu His Ala His Ile Glu Phe Val Pro His Asp Leu Ser Lys Trp Arg 
            20                  25                  30          


Asp Ile Ser Ile Glu His Leu Asp Cys Pro Ile Tyr Gly Asp Leu Ser 
        35                  40                  45              


Asn Gln Ala Thr Gly Thr Ile Ser Val Lys Tyr Ser Ser Val Gln Trp 
    50                  55                  60                  


Gly Leu Lys Asn Asn Ile Asp Gly Tyr Leu Cys Ile Ser Ala Lys Trp 
65                  70                  75                  80  


Ser Val Thr Cys Asp Tyr Arg Trp Tyr Gly Ser Lys Tyr Ile Ser Thr 
                85                  90                  95      


Ser Ile Glu Tyr Val Pro Thr Lys Glu Ser Glu Cys Arg Asp Ala Ile 
            100                 105                 110         


Lys Ser Ser Lys Asn Gly Glu Leu Val Ser Pro His Phe Met Pro Glu 
        115                 120                 125             


Asn Cys Gly Trp Asn Asn Val Leu Thr Glu Ser Val Thr Tyr Thr Thr 
    130                 135                 140                 


Val Ser Ser His Glu Val Lys Leu Asp Pro Tyr Gln Met Thr Phe Val 
145                 150                 155                 160 


Asp Ser Leu Phe Pro Gly Gly Lys Cys Ser Ser Ser Val Cys Ser Thr 
                165                 170                 175     


Ile Tyr His Gln Gly Val Trp Ile Ser Pro Ser Asn Asn Leu Gly Phe 
            180                 185                 190         


Cys Lys Asp Pro Val Asp His Gln Gly Gln Leu Tyr Met Ala Gly Leu 
        195                 200                 205             


Val Gly Ala His Gly Asp Ile Val Lys Glu Val Trp Asn Leu Arg Ser 
    210                 215                 220                 


Val Phe Lys Pro Glu Ile Gly Arg Ser Lys His Leu Thr Gly Ser Cys 
225                 230                 235                 240 


Trp Met Thr Tyr Cys Gly Gln Arg Gly Leu Arg Phe Ser Asp Gly Glu 
                245                 250                 255     


Trp Ala Gly Phe Gln Ile Pro Glu Ile Ser Ala Leu Lys Gln Val Leu 
            260                 265                 270         


Leu Glu Leu Pro Glu Cys Gly Asn Asp Val Leu Val His Ala His Asp 
        275                 280                 285             


Thr Asn Thr Glu Leu Arg Glu Ile Leu Glu His Met Asp Glu Ser Ala 
    290                 295                 300                 


Leu Asn Ala Ile Cys Gln Gln Glu Val Arg Arg Ala Lys Glu Arg Gly 
305                 310                 315                 320 


Val Val Ser Asp Trp Leu Leu Ser Met Met Thr Pro Phe Thr Glu Gly 
                325                 330                 335     


Leu Gly Pro Val Tyr Arg Leu Asn Lys Gly Lys Leu Glu Ala Ser Met 
            340                 345                 350         


Gly Tyr Tyr Arg Lys Val Tyr Ile Asp Ser Ser Asn Ala Pro Gln Ala 
        355                 360                 365             


Phe Gly Gln Thr Glu Asp Lys Glu Ser Val Gly Trp Ser Asp Leu Val 
    370                 375                 380                 


Pro Lys Asp Ala Asp Gly Ala Val Leu Ser Met Tyr Asn Gly Asn Val 
385                 390                 395                 400 


Val Ile Asp Asn Gln Ile Lys Trp Ala Lys Asn Ala Leu Gly Ser His 
                405                 410                 415     


Ile Leu Asp Glu Ile Ser Ala Leu Glu Phe Glu Thr Pro Val Val His 
            420                 425                 430         


His Pro His Leu Thr Ile Leu Ser Val Asn His Ser Asp Leu Val Ser 
        435                 440                 445             


Ser Thr His Pro Asn Gly Gln Gly Val Asn Leu Ile Glu Ser Val Ser 
    450                 455                 460                 


His Trp Ala Gly Gly Leu Trp Ala Ser Ile Gly Ser Gly Leu Met Ile 
465                 470                 475                 480 


Leu Val Leu Val Ala Leu Val Gly Phe Cys Thr Ile Lys Val Cys Leu 
                485                 490                 495     


Ala Tyr Val Pro Ser Ile Trp Val Gln Lys Asn Arg Ser Gly Lys Arg 
            500                 505                 510         


Arg Gly Thr Thr Ser Gln Arg Ser Thr Glu Gln Glu Met Phe Glu Leu 
        515                 520                 525             


Ser Ala Val 
    530     


<210>  534
<211>  519
<212>  PRT
<213>  Perch perhabdovirus

<400>  534

Met Asn Thr Leu Ile Lys Ile Leu Leu Ile Ile Ile Ile Leu Arg Glu 
1               5                   10                  15      


Ala Arg Ser His Ile Val Leu Val Pro Leu Asp Leu Gly Asp Trp Arg 
            20                  25                  30          


Thr Thr Glu Ala Asp Gln Leu Asp Cys Pro Met His Gly Asp Leu Ser 
        35                  40                  45              


Asn Gln Gly Thr Gln Ala Ile Glu Leu Glu Tyr His Thr Ala Ser Trp 
    50                  55                  60                  


Gly Leu Lys Asn Asn Ile Ala Gly Ser Leu Cys Val Thr Ala Lys Trp 
65                  70                  75                  80  


Ser Ile Thr Cys Asp Tyr Arg Trp Tyr Gly Ser Lys Tyr Ile Ser Thr 
                85                  90                  95      


Val Ile Glu Tyr Leu Pro Thr Thr Pro Glu Met Cys Lys Glu Ala Lys 
            100                 105                 110         


Arg Ala Ser Asp Arg Gly Glu Ser Leu Ala Pro His Phe Pro Thr Glu 
        115                 120                 125             


Asn Cys Gly Trp Asn Asn Val Leu Thr Glu Ser Gln Glu Phe Thr Thr 
    130                 135                 140                 


Leu Thr Ser His Pro Val Lys Leu Asp Ala Tyr Ser Phe Ile Leu Ile 
145                 150                 155                 160 


Asp Ser Met Phe Glu Gly Gly Arg Cys Gln Ser Lys Glu Cys Pro Val 
                165                 170                 175     


Val Phe His Gln Gly Met Trp Ile Ala Asp Gln Glu Ala Phe Gly Phe 
            180                 185                 190         


Cys Lys Asp Leu Asp Lys His Arg Gly Leu Leu Phe Lys Thr Gly Leu 
        195                 200                 205             


Arg Asn Ser Leu Gly Glu Ile Val Arg Gln Glu Trp Asn Leu Asn Ser 
    210                 215                 220                 


Val Phe Gln Pro Glu Ile Gly Arg Glu Lys His Phe Lys Gly Ala Cys 
225                 230                 235                 240 


Lys Met Ser Tyr Cys Gly Asn Ser Gly Val Arg Phe Ser Asp Arg Glu 
                245                 250                 255     


Trp Phe Gln Leu Gly Thr Pro Ser Asp Asn Gly Ile Lys Lys Ile Ile 
            260                 265                 270         


Glu Gly Leu Pro Glu Cys Gly Glu Asp Asn Leu Ile His Ser His Asp 
        275                 280                 285             


Thr Ser Asn Thr Leu Lys Glu Leu Ala Glu His Val Asp Glu Ile Ala 
    290                 295                 300                 


Leu Asn Ala Ile Cys Leu Gln Glu Val Arg Arg Ala Arg Asp Thr Lys 
305                 310                 315                 320 


Ala Val Ser Asp Trp Leu Leu Ser Met Met Ser Pro Phe Ser Glu Gly 
                325                 330                 335     


Ile Gly Lys Val Tyr Arg Ile His Lys Gly Arg Leu Glu Ser Thr Val 
            340                 345                 350         


Gly Phe Tyr Arg Lys Val Val Leu Glu Gly Asp Gly Thr Pro Glu Arg 
        355                 360                 365             


Leu Gly Val Gly Leu Asp Lys Lys Pro Val Ser Trp Asp Gln Phe Val 
    370                 375                 380                 


Val Lys Thr Asn Asp Thr Arg Ile Gln Ser Met Phe Asn Gly Asn Thr 
385                 390                 395                 400 


Val Val Asn Gly Lys Ile Lys Trp Val Lys Asn Val Leu Gly Ala His 
                405                 410                 415     


Ile Leu Asp Glu Ile Ser Ala Leu Glu Phe Asp Val Pro Leu Ile Pro 
            420                 425                 430         


His Pro His Leu Asp Gly Leu Lys Phe Asn Glu Ser His Thr Ile Ser 
        435                 440                 445             


Ser His His Pro Asn Gly Lys Gly Val Asn Phe Val Glu Ser Val Thr 
    450                 455                 460                 


His Trp Ala Gly Gly Leu Trp Glu Ser Ile Gly Ser Ser Ala Val Ile 
465                 470                 475                 480 


Ile Val Val Leu Leu Ile Cys Ala Phe Val Ala Val Lys Phe Cys Gln 
                485                 490                 495     


Arg Leu Ile Pro Ser Arg Arg Pro Pro Thr Arg Glu Ser Ser Glu Asn 
            500                 505                 510         


Val Phe Met Leu Arg Thr Val 
        515                 


<210>  535
<211>  517
<212>  PRT
<213>  Sea trout perhabdovirus

<400>  535

Met Asp Leu Leu Leu Lys Ile Leu Leu Ile Ile Ile Ile Ile Lys Glu 
1               5                   10                  15      


Ala Gln Ser Arg Ile Ala Phe Val Pro Leu Asp Leu Gly Thr Trp Arg 
            20                  25                  30          


Ala Thr Ser Val Asp Gln Leu Asp Cys Pro Met Gln Gly Asp Leu Val 
        35                  40                  45              


Asn Gln Gly Thr Asp Ala Ile Glu Val Gln Tyr Gln Thr Ala Ala Trp 
    50                  55                  60                  


Gly Leu Lys Asn Asn Val Ala Gly Lys Leu Cys Val Thr Ala Lys Trp 
65                  70                  75                  80  


Ser Ile Thr Cys Asp Tyr Arg Trp Tyr Gly Ser Lys Tyr Ile Ser Thr 
                85                  90                  95      


Gln Ile Glu Tyr Leu Pro Thr Thr Pro Glu Met Cys Lys Glu Ala Lys 
            100                 105                 110         


Arg Gln Leu Asp Arg Gly Glu Leu Leu Ser Pro His Phe Ser Ser Glu 
        115                 120                 125             


Asn Cys Gly Trp Asn Asn Val Leu Thr Glu Ser Glu Thr Tyr Thr Thr 
    130                 135                 140                 


Ile Val Pro His Pro Val Lys Leu Asp Ala Tyr Ser Leu Thr Leu Ile 
145                 150                 155                 160 


Asp Asn Ile Phe Glu Gly Gly Lys Cys His Glu Glu Glu Cys Pro Ser 
                165                 170                 175     


Leu Leu His Gln Gly Phe Trp Ile Ala Asp Lys Asn Ser Leu Gly Leu 
            180                 185                 190         


Cys Lys Gln Leu Asp Pro His Ile Gly Arg Phe Phe Lys Thr Gly Leu 
        195                 200                 205             


Arg Asn Ser Met Gly Thr Val Val Arg Gln Gln Trp Asp Val Asn Ser 
    210                 215                 220                 


Val Phe Gln Pro Glu Ile Gly Arg Glu Lys Asn Phe Asn Gly Ala Cys 
225                 230                 235                 240 


Thr Met Glu Phe Cys Gly His Gln Gly Leu Arg Phe Ala Asp Arg Glu 
                245                 250                 255     


Trp Phe Lys Ile Pro Glu Gln Ala Asp Gln Thr Leu Lys Lys Val Phe 
            260                 265                 270         


Lys Asp Leu Pro Pro Cys Gly Thr Asp Asn Leu Val His Ser His Asp 
        275                 280                 285             


Ile Asn Thr Asp Val Lys Glu Ile Thr Glu His Val His Glu Val Ala 
    290                 295                 300                 


Leu His Ala Ile Cys Leu Gln Glu Val Arg Arg Ala Lys Asp Ser Asn 
305                 310                 315                 320 


Thr Val Ser Asp Trp Leu Leu Ser Met Met Thr Pro Phe Ser Glu Gly 
                325                 330                 335     


Ala Gly Pro Val Tyr Arg Ile His Asn Gly Glu Leu Glu Ser Thr Val 
            340                 345                 350         


Gly Phe Tyr Arg Lys Val Leu Ile Glu Gly Gly Gly Thr Thr Glu Gln 
        355                 360                 365             


Leu Gly Ile Gly Phe Asp Lys Lys Pro Ile Lys Trp Asp Gln Phe Val 
    370                 375                 380                 


Val Lys Thr Asn Asp Thr Arg Val Gln Ser Met Tyr Asn Gly Asn Thr 
385                 390                 395                 400 


Val Val Asn Gly Glu Ile His Trp Ala Lys Asn Val Leu Gly Ser His 
                405                 410                 415     


Ile Leu Asp Glu Ile Ala Ala Leu Glu Phe Asp Ile Pro Leu Ile Gln 
            420                 425                 430         


His Pro His Leu Asp Gly Ile Leu Ile Asn Glu Thr His Val Ile Ser 
        435                 440                 445             


Ser His His Pro Asn Gly Lys Gly Val Asn Phe Val Glu Ser Val Thr 
    450                 455                 460                 


His Trp Ala Gly Gly Ile Trp Glu Ser Val Gly Ser Ser Ala Ile Ile 
465                 470                 475                 480 


Ile Ala Val Ile Leu Val Val Gly Phe Val Leu Val Lys Leu Cys Met 
                485                 490                 495     


Arg Phe Ser Met Pro Val Arg Arg Glu Arg Arg Glu Glu Gly Met Met 
            500                 505                 510         


Met Leu Gln Arg Ala 
        515         


<210>  536
<211>  505
<212>  PRT
<213>  Minto sawgrhavirus

<400>  536

Met Met Ile Val Leu Phe Phe Phe Thr Thr Phe Thr Tyr Ala Ile Gly 
1               5                   10                  15      


Leu Trp Glu Pro Glu Leu Gly Val Tyr Trp Val Pro Thr Pro Ile Thr 
            20                  25                  30          


Pro Trp Lys Ala Ala Thr His Asn Asn Leu Ile Cys Pro Pro Pro Ala 
        35                  40                  45              


Thr Arg Ile Ser Thr Ser Leu Ser Pro Ser Phe Asn Tyr Thr Val Pro 
    50                  55                  60                  


Asn Pro Arg Asn Leu Met Gly His Met Gln His Asp Gly Trp Leu Cys 
65                  70                  75                  80  


Val Ser Ser Leu Tyr Ala Thr Thr Cys Asp Thr Asn Phe Trp Gly His 
                85                  90                  95      


Gln Thr Ile Thr Gln Ser Asn Leu Pro Val Arg Met Thr Ser Ala Ala 
            100                 105                 110         


Cys Lys Lys Ala Val Arg Glu His Ile Leu Gly Glu Leu Ala Pro Pro 
        115                 120                 125             


Arg Tyr Pro Asp Pro Tyr Cys Tyr Trp Met Ala Ser His Thr Gln Ala 
    130                 135                 140                 


Ile Thr Gln Ile Arg Val Ile Glu His Pro Val Thr Ser Asp Leu Tyr 
145                 150                 155                 160 


Thr Glu Thr Phe Val Asn Ser Leu Phe Pro Gly Thr His Cys Ala Met 
                165                 170                 175     


Asn Pro Cys Thr Thr Val His Pro Asp Thr Met Trp Glu Thr Thr Thr 
            180                 185                 190         


Ile Ile Lys Lys Asp Cys Lys Ile Leu Pro Asn Ser Asn Phe Thr Gly 
        195                 200                 205             


Tyr Lys Asp Pro Arg Arg Pro Asp Arg Glu Trp Val Val Ile Asp Asn 
    210                 215                 220                 


Asp Ser Ala Ile Tyr Leu Ala Gly Ser Cys His Met Gln Tyr Cys Gly 
225                 230                 235                 240 


Gln Lys Gly Leu Arg Thr Ala Ser Gly Gln Trp Ile Pro Tyr Glu Gly 
                245                 250                 255     


Pro Thr Lys Tyr Pro Asp Cys Pro Glu Ser Trp Leu Thr Arg Ser Thr 
            260                 265                 270         


Glu His Ser Asn Glu Leu Lys Val Asn Leu Glu Val Gln Glu Val Glu 
        275                 280                 285             


Ser Arg Arg Ala Cys Ile Glu Ala Thr Gln Arg Ile Arg Asp Gly Ala 
    290                 295                 300                 


Pro Ile Ser Phe His Leu Leu Ser Tyr Phe Gln Pro Arg Arg Thr Gly 
305                 310                 315                 320 


Tyr Tyr His Val Tyr Arg Ile Tyr Lys Gly Ile Leu Gln Tyr Ser Lys 
                325                 330                 335     


Ala Trp Tyr Glu Pro Leu Lys Asp Leu Asn Pro Ser Gly Lys Tyr Thr 
            340                 345                 350         


Leu Gly His Phe Pro Asn Ser Ser Ile Tyr Lys Ile Asp Pro Val Arg 
        355                 360                 365             


Ala Asp Lys Asn Gly Thr Leu Ser Ala Phe Asn Gly Val His Val Ala 
    370                 375                 380                 


Pro Asp Gly Thr Ile Ile Val Pro Glu Val Glu Leu Phe Lys Asp Thr 
385                 390                 395                 400 


Tyr Ser Asp Thr Leu Leu Tyr Gln Lys Ala Arg Leu Ile Asp His Pro 
                405                 410                 415     


Ala Thr Ala Ile Gln Ala Asn Tyr Thr Thr Leu Val Pro His Tyr Thr 
            420                 425                 430         


Ser Thr Thr Ser Phe His Arg Pro Asp Leu Thr Ala Trp Gly Ala Ser 
        435                 440                 445             


Val Trp Ser Ala Phe Trp Gly Lys Val Met Leu Ile Ser Met Ala Val 
    450                 455                 460                 


Ala Ser Val Leu Ile Ile Tyr Val Ala Ile Lys Cys Val Pro Trp Ala 
465                 470                 475                 480 


Ala Ile Thr Arg Arg Arg Ala Gln Pro Met Pro Ala Val Val Thr Tyr 
                485                 490                 495     


Thr Pro Ser Asn Ser Arg Val Asn Trp 
            500                 505 


<210>  537
<211>  506
<212>  PRT
<213>  Sawgrass sawgrhavirus

<400>  537

Met Leu Thr His Phe Thr Leu Leu Leu Phe Ile Pro His Thr Phe Gly 
1               5                   10                  15      


Trp Glu Pro Glu Leu Gly Glu Tyr Trp Ala Pro Ile Pro Val Thr Pro 
            20                  25                  30          


Trp Arg Pro Ala Thr Lys Ser Asp Phe Ser Cys Pro Ser Leu Arg Val 
        35                  40                  45              


Asp Pro Ile Pro Pro Leu Gln Leu Val Asn Asn Thr Arg Met Ala Tyr 
    50                  55                  60                  


Leu Met Glu Gly Lys Ala Arg Lys Glu His Pro Gly Trp Leu Cys Val 
65                  70                  75                  80  


Arg Lys Met Tyr Gln Thr Thr Cys Asp Thr Asn Phe Trp Gly His Gln 
                85                  90                  95      


Thr Ile Thr His Glu Glu Leu Ala Leu Pro Ala Asp Gln Thr Glu Cys 
            100                 105                 110         


Arg Gln Ala Ile Ala His Tyr Ile Lys Gly Thr Tyr Glu Asp Pro Arg 
        115                 120                 125             


His Pro Asp Pro Val Cys Thr Trp Met Ala Ala Glu Lys Val Tyr Asn 
    130                 135                 140                 


Pro Asn Thr Ala Leu Leu Pro His Ser Thr Val Val Asp Pro Phe Ser 
145                 150                 155                 160 


Tyr Thr Phe Met Asp Ser Leu Phe Pro Gly Thr His Cys Lys Thr Ala 
                165                 170                 175     


Pro Cys Pro Thr Val His Pro Asp Val Leu Trp His Thr Val Thr Pro 
            180                 185                 190         


Leu Thr Glu Asp Cys Pro Gly His Thr Ile Ile Pro Ile Lys Ile Tyr 
        195                 200                 205             


Asn Asp Lys Ser Ala Arg Lys Lys Thr His Glu Trp Leu Ser Val Ser 
    210                 215                 220                 


Asp Gly Pro Leu Ile Pro Leu Gly Gly Ser Cys Ser Leu Thr Tyr Cys 
225                 230                 235                 240 


Gly Gln Leu Gly Leu Arg Thr Pro Gly Gly His Trp Tyr Pro Tyr Pro 
                245                 250                 255     


Gly Ser Lys Arg Tyr Pro Glu Cys Lys Asp Ala Trp Arg Ala Thr Pro 
            260                 265                 270         


Thr Phe Glu Gly Glu Gly Met Arg Leu Asp Ile Glu Leu Gln Glu Ile 
        275                 280                 285             


Leu Ala Arg Arg Glu Cys Ile Asn Val Leu Gln Gln Ile Gln Ser Gly 
    290                 295                 300                 


Ala Ala Pro Thr Phe His Met Leu Ser His Phe Gln Pro Arg His Ala 
305                 310                 315                 320 


Gly Tyr Tyr Arg Ala Tyr Arg Met Lys Asn Asn Val Ile Glu Tyr Ser 
                325                 330                 335     


Leu Ala Leu Tyr Asp Pro Ile Phe Asn Val Ser Val Pro Pro Gln Val 
            340                 345                 350         


Asn Phe Gly Ala Trp Gln Asn Gly Thr Arg Tyr Tyr Leu Pro Leu Val 
        355                 360                 365             


Glu Ser Gly Tyr Pro Gly Thr Leu Ser Ala Phe Asn Gly Ile His Val 
    370                 375                 380                 


Met His Asn Lys Thr Val Val Val Pro Glu Leu Glu Leu Tyr Lys Glu 
385                 390                 395                 400 


His Tyr Ala Glu Thr Leu Phe Tyr Tyr Thr Ala Gln Ile Ala Glu His 
                405                 410                 415     


Pro Ser Gln Met Arg Gln Asp Asn Glu Thr Glu Leu Thr Pro Pro Thr 
            420                 425                 430         


Arg Thr Thr Ile Thr Val Lys Arg Pro Ser Ile Gly Gly Trp Leu Ser 
        435                 440                 445             


Ser Met Trp Gly Ser Val Trp Gly Lys Val Thr Ser Ala Ile Gly Leu 
    450                 455                 460                 


Val Leu Ala Ile Phe Val Ile Gly Leu Leu Ile Lys Ile Leu Pro Trp 
465                 470                 475                 480 


Gly Arg Leu Leu Arg Arg Pro Ser Thr Pro Ala Pro Arg Thr Val Val 
                485                 490                 495     


Tyr Thr Pro Ala Thr Gly Asn Val Ala Trp 
            500                 505     


<210>  538
<211>  562
<212>  PRT
<213>  Capitata sigmavirus

<400>  538

Met Ser Asn Arg Ser Ile Lys Asn Phe Lys Met Glu Asn Ile Ile Asn 
1               5                   10                  15      


Lys Tyr Arg Leu Val Ile Tyr Phe Ser Leu Ile Leu Leu Asp Lys Phe 
            20                  25                  30          


Asn Thr Ile Lys Ser Glu Ser Phe Ser Tyr Pro Thr Ser Arg Ile Leu 
        35                  40                  45              


Asn Trp Asn Pro Val Ser Tyr Asn Tyr Leu Thr Cys Pro Gln His His 
    50                  55                  60                  


Thr Ser Tyr Asp Ser Thr Ile His Lys His Leu Asp Glu Ile Leu Val 
65                  70                  75                  80  


Arg Lys Pro Ile Tyr Asn Asp Asn Leu Phe Val Asp Gly Tyr Leu Cys 
                85                  90                  95      


Arg Lys Val Ala Tyr Ile Thr Arg Cys Val Thr Ser Trp Thr Phe Thr 
            100                 105                 110         


Ser Ser Ile Asn Lys Leu Ile His Gly Leu Ser Val Ser Arg Thr Glu 
        115                 120                 125             


Cys Leu Glu Lys Ile Lys Gln Leu Glu Glu Asp Glu Leu Ile Gln Glu 
    130                 135                 140                 


Arg Phe Lys Glu Pro Asp Cys Arg Trp Asn Lys Ile Tyr Asp Val Glu 
145                 150                 155                 160 


Ser Ile Asn Phe Glu Ile Ile Asn His Lys Val Lys Leu Asp Pro Tyr 
                165                 170                 175     


Thr Asn Asn Leu Val Asp Pro Ile Phe Pro Gly Gly Ile Thr His Ser 
            180                 185                 190         


Ser Lys Ser Ala Thr Ile His Asn Asp Val Ile Trp Ile Ser Lys Val 
        195                 200                 205             


Asn Thr Thr Phe Thr Cys Asn Arg His Ile Glu Met Lys Gly Ile Val 
    210                 215                 220                 


Tyr Thr Lys Leu Gly Val Ser Glu Arg Asn Leu Ser Gly Glu Ile Ala 
225                 230                 235                 240 


Met Leu His Ile Glu Gly Phe Lys Asp Lys Ser Phe Gln Gly Ala Cys 
                245                 250                 255     


Leu Leu Met Tyr Cys Asn Glu Gln Gly Val Arg Phe Ser Asp Gly Glu 
            260                 265                 270         


Trp Ile Ser Ile Ser Tyr Asp Leu Asn Phe Asn His Ser Phe Thr Asn 
        275                 280                 285             


Leu Leu Ser Asp Leu Asn Pro Cys Ser Ser Thr Val Ser Leu Ser Leu 
    290                 295                 300                 


Ser Asn Asn Tyr Gln Arg Asn Ile Ile Thr Met Glu Leu Thr Leu Glu 
305                 310                 315                 320 


Thr Ile Phe Arg Leu Arg Cys Glu Asp Thr Ile Ala Lys Leu Ile Asn 
                325                 330                 335     


His Ile Pro Ile Thr Pro Tyr Asp Val Ser Phe Leu Ala Gln Ser Tyr 
            340                 345                 350         


Pro Gly Pro Gly Asn Val Tyr Gln Ile Arg Asp Asn Val Leu Met Gln 
        355                 360                 365             


Ala Gln Gly Leu Tyr Glu Leu Leu Leu Val Asn Ser Ser Glu Ser Asn 
    370                 375                 380                 


Gly Asp Val Ile Gly Tyr His Val Asn Gly Thr Ala Phe Ile Glu Asp 
385                 390                 395                 400 


Arg Trp Tyr Thr Asp Asn His Lys Ser Ile His Gly Leu Asn Gly Ile 
                405                 410                 415     


Val Lys Phe Gly Gly Arg Ile Arg Tyr Pro Gly Asp Ile Phe Lys Arg 
            420                 425                 430         


Arg Arg Thr His Asp Ser Leu Leu Lys Ala Lys Pro Leu Leu Lys Val 
        435                 440                 445             


Ser His Pro Thr Val Leu Asp Leu Ser Lys Ile Ile Asn Ser Thr Asp 
    450                 455                 460                 


Ile Glu Tyr Gly Tyr His Pro Asn Ser Val Leu Asp Asn Ser Ile Leu 
465                 470                 475                 480 


Glu Asp Thr Ile Ser Glu Ile Lys Tyr Leu Trp Ser His Leu Phe Asp 
                485                 490                 495     


Phe Ser Val Leu Gly Gln Ile Leu Trp Val Ala Leu Val Val Ile Val 
            500                 505                 510         


Leu Val Ile Gly Leu Ser Ser Tyr Lys Val Trp Arg Arg Val Arg Glu 
        515                 520                 525             


Thr Gln Thr Leu Asp Asp Ile Glu Ser Ile Asn Arg Arg Gln Asn Leu 
    530                 535                 540                 


His Phe Arg Asp Ile Asp Ser Leu Arg Ser Leu Gly Val Asp Ser Leu 
545                 550                 555                 560 


Ser Pro 
        


<210>  539
<211>  624
<212>  PRT
<213>  Drosophila affinis sigmavirus

<400>  539

Met Asn Pro Arg His Ile Ser Phe Asn Pro Leu Pro Arg Cys Pro Trp 
1               5                   10                  15      


Phe Leu Val Leu Ser Leu Ile Leu Val Leu Ser Leu Gly Ser Pro Glu 
            20                  25                  30          


Leu Asn Pro Gly Gly Tyr Ile Pro Leu Lys His His Val Lys Asp Met 
        35                  40                  45              


Arg Asp Gln Lys Lys Ser Ser Asn Ile Phe Leu Val Phe Pro Val Tyr 
    50                  55                  60                  


Asp Glu Cys Lys Trp Ala Pro Val Asp His Lys Thr Leu Arg Cys Pro 
65                  70                  75                  80  


Ile Gly Ser Gln Thr Phe Pro Gly Leu Asp Asn Pro Lys Thr Phe Lys 
                85                  90                  95      


Val Pro Val Ser Arg Pro Tyr Tyr Gln Glu Ser Gly Thr Ile Pro Gly 
            100                 105                 110         


His Leu Cys Thr Lys Tyr Lys Leu Thr Thr Ile Cys Asp Ser Asn Trp 
        115                 120                 125             


Ala Ala Val Glu Glu Val Thr His Thr Thr His Leu Gln Asp Ile Lys 
    130                 135                 140                 


Leu Ser Glu Cys Leu Ala Lys Val Asn Ala Arg Ala Ser Gly Ser Asp 
145                 150                 155                 160 


Pro Glu Phe Leu Glu His Pro Ile Lys Gln Cys Thr Trp Thr Lys Thr 
                165                 170                 175     


Glu Thr Ser Thr Ile Glu Arg Val Val Val Glu Pro His Pro Val Ile 
            180                 185                 190         


Tyr Asp Pro Tyr Arg Gly Lys Tyr Val Asp Pro Ile Phe Pro Gly Gly 
        195                 200                 205             


Ser Tyr Phe Gly Pro Gly Thr Ile Thr Asn Ser Lys Ser Lys Ala Trp 
    210                 215                 220                 


Ile Pro Ala Met Ser Asp Lys Pro Glu Ala Cys Lys His Glu Gln Ser 
225                 230                 235                 240 


Ile Asn Ser Ile Val Tyr Ile Pro Asn Thr Ser Asp His Ser Ala Val 
                245                 250                 255     


Asn Phe Lys Glu His Gly Lys Ile Trp Thr Asp Ile Thr Arg Glu Lys 
            260                 265                 270         


Ser Phe Thr Asp Ala Cys Arg Met Thr Phe Cys Asp Lys Glu Gly Val 
        275                 280                 285             


Arg Phe Pro Asp Gly Glu Leu Phe Phe Ile Gly Lys Ala Thr Tyr Ile 
    290                 295                 300                 


Glu Gly Gln Phe Ile Leu Met Ile Asn Ser Leu Pro Ile Cys Ala Glu 
305                 310                 315                 320 


Glu Thr Ile Val Lys Leu Gln Asp Pro Phe Glu Glu Gly His Phe Ser 
                325                 330                 335     


Ser Ser Leu Gly Met Ala Gln Ile Phe Leu Met Lys Cys His Glu Thr 
            340                 345                 350         


Ile Ser Lys Leu Arg Asn Arg Asp Pro Val Ser Gln Val Asp Ile Ser 
        355                 360                 365             


Tyr Leu Ser Gln Ser Tyr Pro Gly His Gly Leu Ala Tyr Lys Trp Tyr 
    370                 375                 380                 


Glu Gly Thr Leu Thr Ser Cys Leu Val Asn Tyr Val Ile Gly Ala Leu 
385                 390                 395                 400 


Val Asp Lys Asn Lys Lys Ile Val Leu Gly His Gly Gly Thr Lys Ser 
                405                 410                 415     


His Val Ala Gly Gly Tyr Ile Tyr Arg Asp Trp Ser Asp Ser Pro Val 
            420                 425                 430         


Pro Gly Thr Leu Ile Gly Pro Asn Gly Ile Leu Asn Ile Ser Gly Thr 
        435                 440                 445             


Leu Glu Ile Pro Phe Asp Asn Met Phe Arg Glu Phe Ile His Ser Glu 
    450                 455                 460                 


Leu Thr Gln Glu Thr Gly Tyr His Asn Val Ser His His Glu Leu Lys 
465                 470                 475                 480 


Pro Ile Ile Asp Ser Leu Pro Asp Asp Ile Asp Trp His Glu His Pro 
                485                 490                 495     


Asn Asn Ser Ile Ile Pro Ser Asp Lys Pro Gly Ile Ile Gly Tyr Val 
            500                 505                 510         


Lys Gly Ser Trp His Thr Trp Gln Met Tyr Leu Tyr Ile Trp Gly Leu 
        515                 520                 525             


Leu Met Ile Ile Gly Gly Val Ile Tyr Ile Phe Val Ala Tyr Pro Gly 
    530                 535                 540                 


Val Trp Glu Phe Phe Lys Ile Thr Phe Leu Cys Leu Phe Gly Trp Ile 
545                 550                 555                 560 


Tyr Tyr Val Pro Lys Leu Phe Cys Leu Cys Cys Cys Lys Ile Thr Ser 
                565                 570                 575     


Val Ile Thr Asp Arg Thr Lys Arg Glu Gly Arg Arg His Glu Ser Asn 
            580                 585                 590         


His Tyr Gln Thr Asp Asn Glu Arg Gly Leu Asn Ile Pro Leu Gln Gln 
        595                 600                 605             


Val Pro Ile Ser Thr Asn Arg Ala Leu Met Arg Val Pro Asn Phe His 
    610                 615                 620                 


<210>  540
<211>  511
<212>  PRT
<213>  Chaco sripuvirus

<400>  540

Met Gln Lys Tyr Gly Phe Ile Leu Leu Ala Leu Gly Ala Ile Gln Val 
1               5                   10                  15      


Thr His Gly Asn Leu Phe Tyr Phe Pro Val Glu Lys Asp Ile His Trp 
            20                  25                  30          


His Pro Ile Asn Tyr Thr Ser Ile Arg Cys Pro Ile Arg Ala Gly Asp 
        35                  40                  45              


Gln Tyr Pro Gly Tyr Ser Ala Asn Val Gln Phe Arg Val Pro Tyr Ser 
    50                  55                  60                  


Asp Ser Ser Asn Ile Ile Asn Gly His Ser Cys His Lys Thr Gln Trp 
65                  70                  75                  80  


Val Ser Glu Cys Thr Glu Thr Trp Tyr Trp Thr Thr Asp Val Lys Gln 
                85                  90                  95      


Tyr Ile Arg Val Leu Pro Val Ser Leu Asn Glu Cys Leu Glu Glu Lys 
            100                 105                 110         


Glu Lys Arg Gly Gln Gly Lys Ser Ile Ala Pro Phe Phe Glu Ala Pro 
        115                 120                 125             


Val Cys Gln Trp Ala Asn Thr Val Arg Lys Glu Asn Ser Phe Val Ile 
    130                 135                 140                 


Leu Asn Glu Lys Arg Val Gln Leu Asp Pro Tyr Asn Gly Asn Val Val 
145                 150                 155                 160 


Asp Pro Leu Phe Pro Asn Gly Arg Cys Ser Thr Pro Val Lys Gly Cys 
                165                 170                 175     


Pro Thr Ile Gln Asp Asn Val Leu Trp Phe Thr Thr Glu Asp Pro Ile 
            180                 185                 190         


Lys Gly Val His Met Arg Thr Ile Asn Leu Lys Tyr Ala Pro Pro Arg 
        195                 200                 205             


Gly Asp Met Lys Glu Leu Ser Ile Trp Gly Glu Gly Val Pro Val Thr 
    210                 215                 220                 


Lys Met Ser Lys Ser Cys Lys Met Ser Tyr Ala Asn Glu Glu Gly Val 
225                 230                 235                 240 


Arg Phe Glu Ser Gly Leu Trp Gly Ile Pro Ile Pro Gly Ser Asp Gly 
                245                 250                 255     


Lys Phe Thr Gln Trp Lys Asp Asn Leu Glu Asn Cys Pro Glu Gly Thr 
            260                 265                 270         


Leu Leu Lys Leu Pro Asn Ala His Glu Glu Ile Ser Glu His Gln Ile 
        275                 280                 285             


Glu Ile Glu Asp Leu Val Leu Ser Leu Thr Cys Phe Glu Met Ile Asn 
    290                 295                 300                 


Asn Phe Arg Asp Thr Gly Lys Ile Ser Phe Thr Asp Leu Ala Leu Leu 
305                 310                 315                 320 


Thr Pro Asp His Pro Gly Leu Gly Asn Val Tyr Arg Ile Asn Lys Gly 
                325                 330                 335     


Val Leu Glu Ala Ser Ser Ala Phe Tyr Gln Gln Cys Lys Ile Lys Pro 
            340                 345                 350         


Asn Lys Asn Asp Val Ile Cys Tyr Gly Gly Asn Asp Phe Asn Thr Glu 
        355                 360                 365             


Asn Lys Trp Lys Arg Trp Val Asp Ser Gly Thr Pro Gly Thr Leu Ser 
    370                 375                 380                 


Gly Tyr Asn Gly Val Tyr Lys Met Gly Gly Lys Ile Ile Asn Ala His 
385                 390                 395                 400 


Glu Asn Leu Met Thr Asn Arg Ile Ile Asp Glu Asp Ile Leu Lys Arg 
                405                 410                 415     


Asp Leu Lys Thr Val Arg His Pro Ile Glu Val Ser Val Arg Lys Asn 
            420                 425                 430         


Ser Ser His Pro Ile Tyr Phe Phe Asp Trp Thr Gly Glu Arg Gly Asn 
        435                 440                 445             


Pro Val Glu Asp Val Phe Glu Gly Leu Asn Asn Phe Trp Arg Lys Ala 
    450                 455                 460                 


Ile Glu Trp Ile Ala Ile Val Ser Phe Thr Phe Leu Leu Cys Ile Ala 
465                 470                 475                 480 


Ile Phe Ile Leu Phe Lys Leu Leu Gly Met Phe Arg Ser Asn Lys Lys 
                485                 490                 495     


Asp Arg Leu Ala Gly Ser Gly Glu His Glu Met Ser Leu Phe Arg 
            500                 505                 510     


<210>  541
<211>  510
<212>  PRT
<213>  sripur sripuvirus

<400>  541

Met Lys Thr Ser Tyr Gly Ile Ile Leu Leu Ile Cys Gly Val Ile Ser 
1               5                   10                  15      


Pro Ala Phe Asn Tyr Val Phe His Tyr Pro Leu Glu Lys Asn Ile His 
            20                  25                  30          


Trp Tyr Pro Ala Asn His Ser Ser Leu Arg Cys Pro Val Arg Ser Ala 
        35                  40                  45              


Arg Ile Leu Asp Thr Pro Thr Gly Gly Ile Thr Leu Gln Leu Pro Gly 
    50                  55                  60                  


Asn Pro Ser Asn His Asp Ile Pro Gly Tyr Ser Cys His Lys Thr Glu 
65                  70                  75                  80  


Trp Val Ser Glu Cys Val Glu Thr Trp Tyr Trp Ser Thr Asp Val Lys 
                85                  90                  95      


Glu Tyr Ile Arg Ser Val Pro Val Thr Phe Glu Glu Cys Gln Arg Ala 
            100                 105                 110         


Leu Gln Asp Lys Ser Ile Gly Asn Glu Val Ser Pro Phe Phe Thr Ala 
        115                 120                 125             


Pro Thr Cys Gln Trp Ser Asn Thr Val Arg Lys Val Asn Thr Phe Val 
    130                 135                 140                 


Ile Val His Ser Lys Asp Ala Lys Leu Asp Pro Tyr Asn Leu Asp Arg 
145                 150                 155                 160 


Val Asp Pro Ile Phe Pro Gly Gly Arg Cys Lys Ser Lys Glu Lys Tyr 
                165                 170                 175     


Cys Pro Thr Ile Gln Ala Gly Val Ile Trp Leu Gln Lys Val Ser Gln 
            180                 185                 190         


Arg Ile Thr Ile Glu Trp Gln Thr Ile Lys Ala Lys Tyr Lys Arg Ile 
        195                 200                 205             


Gly Asn Asn Met Glu Asp Trp Lys Leu Trp Gly Gly Gly Met Pro Thr 
    210                 215                 220                 


Ser Thr Phe Arg Gly Ala Cys Lys Met Asp Phe Ala Ala Lys Thr Gly 
225                 230                 235                 240 


Ile Arg Ala Ser Asn Gly Phe Trp Phe His Val Pro Asn Ile Ser Asp 
                245                 250                 255     


Ser Ala Phe Lys Asp Ala Phe Asn Ala Met Thr Gln Cys Pro Gln Asn 
            260                 265                 270         


Thr Glu Val Lys Phe Pro Ser Ala His Glu Glu Val Ala Glu His Glu 
        275                 280                 285             


Met Glu Ile Gln Asp Leu Ile Leu Thr Leu Arg Cys Arg Asp Ile Ile 
    290                 295                 300                 


Asp Lys Phe Ala Glu Thr Gly Gln Ile Ser Phe Met Asp Leu Ser Leu 
305                 310                 315                 320 


Phe Asp Pro Asp Asn Glu Gly Pro Ala His Val Tyr Arg Ile Arg Asn 
                325                 330                 335     


Gly Lys Leu Glu Thr Gly Ile Val Asn Tyr Gly Glu Cys Arg Val Gly 
            340                 345                 350         


Asn Ser Gly Asp Lys Asp Pro Ala Asn Ser Ile Cys Ile Lys Ile Ala 
        355                 360                 365             


Asp Asp Gly Ile Arg Ala Ala Ile Phe Tyr Asp Asp Trp Val Ser Thr 
    370                 375                 380                 


Gly Glu Lys Gly Ile Gln Ser Ala Phe Asn Gly Leu Tyr Arg Glu Asn 
385                 390                 395                 400 


Gly Val Ile Arg His Ala Gly Tyr Asn Leu Phe Ala Asn Lys Leu Thr 
                405                 410                 415     


Glu Lys Asp Ile Glu Lys Gln Asp Leu Gln Gln Val His His Pro Ile 
            420                 425                 430         


Asp Leu Val Ile Glu Lys Phe Met Pro Gly Leu Asn Leu Thr Phe Asp 
        435                 440                 445             


Thr Thr Gly Gln Arg Gly Glu Val Tyr Asp Leu Phe Pro Asp Ile Lys 
    450                 455                 460                 


Gly Phe Trp Arg Ser Val Leu Glu Tyr Ser Val Ile Gly Phe Phe Val 
465                 470                 475                 480 


Leu Ile Thr Ile Ile Phe Ile Trp Ile Val Val Lys Cys Cys Gly Cys 
                485                 490                 495     


Phe Arg Met Lys Arg His Asn Gln Ile Asp Asp Tyr Tyr Asp 
            500                 505                 510 


<210>  542
<211>  514
<212>  PRT
<213>  Charleville sripuvirus

<400>  542

Met Tyr Pro Asn Tyr Gly Ile Phe Ala Ile Leu Leu Ala Leu Ala Val 
1               5                   10                  15      


Ser Val Tyr Cys Asp Tyr Thr Leu Tyr Val Pro Ser Glu Lys Ser Ile 
            20                  25                  30          


His Trp Thr Pro Ala Asn His Thr Ser Leu Arg Cys Pro Ile Arg Ser 
        35                  40                  45              


Ala Val His Pro Val Ser Gly Arg Val Gly Thr Leu Pro Phe Leu Ile 
    50                  55                  60                  


Pro Leu His Pro Asn Asp Asn Asn Val Ala Gly Tyr Ser Cys His Lys 
65                  70                  75                  80  


Ala Glu Trp Thr Ser Glu Cys Thr Glu Thr Trp Tyr Trp Thr Thr Asp 
                85                  90                  95      


Val Lys Gln Tyr Ile Arg Tyr Ile Glu Pro Thr Phe Glu Glu Cys Lys 
            100                 105                 110         


Ala Ala Trp Val Lys Lys Arg Asp Gly Leu Asn Pro Asn Pro Tyr Phe 
        115                 120                 125             


Glu Ala Pro Thr Cys Gln Trp Ala Asn Thr Val Arg Lys Ser His Gln 
    130                 135                 140                 


Phe Thr Met Ile Asn Leu Lys Gln Val Lys Ile Asp Pro Tyr Asn Leu 
145                 150                 155                 160 


Asp Phe Val Asp Pro Ile Phe Pro Gly Gly Arg Cys Ser Asn Gln Asp 
                165                 170                 175     


Ser Cys Lys Thr Val Gln Ser Gly Val Ile Trp His Pro Gln Arg Lys 
            180                 185                 190         


Asn Pro Gln Gln Thr Glu Tyr Ala Trp Lys Asn Val Gln Ala Ser Tyr 
        195                 200                 205             


Gly Lys Ser Arg Lys Glu Ser Asp Val Tyr Leu Ile Trp Gly Gly Gly 
    210                 215                 220                 


Ile Pro Thr Thr Lys Phe Asn Asn Ser Cys Lys Met Asn Phe Lys Gly 
225                 230                 235                 240 


Lys Thr Gly Ile Arg Phe Ser Ser Gly Phe Trp Ala Gly Val Glu Pro 
                245                 250                 255     


Ser Thr Trp His Asp Ser Ala Phe Lys Lys Val Tyr Glu Asp Leu Pro 
            260                 265                 270         


Asn Cys Ser Glu Gly Thr Thr Ile Lys Val Pro Ser Ala His Glu Glu 
        275                 280                 285             


Ile Ala Glu His Glu Met Glu Ile Asp Asp Leu Ile Leu Ser Leu Lys 
    290                 295                 300                 


Cys Tyr Asp Ile Ile Arg Ala Phe Glu Glu Thr Gly Lys Ile Ser Phe 
305                 310                 315                 320 


Leu Asp Leu Gly Phe Phe Asn Pro Asp Thr Glu Gly Pro Ala His Ile 
                325                 330                 335     


Tyr Arg Ile Lys Glu Gly Lys Leu Glu Ala Ala Ser Val Asn Tyr Gln 
            340                 345                 350         


Ala Cys Gln Ile His Pro Lys Pro His Asp Pro Thr Arg Val Ile Cys 
        355                 360                 365             


Lys Asp Ser Lys Ile Lys Val Leu Tyr Asp Glu Trp Val Pro Thr Gly 
    370                 375                 380                 


Val Ser Gly Ile Leu Ser Gly Phe Asn Gly Val Tyr Lys Asp Arg Gly 
385                 390                 395                 400 


Val Val Lys Tyr Ala Gly Tyr Asn Leu Trp Asn Asn Lys Leu Thr Glu 
                405                 410                 415     


Ala Asp Ile Gln Gln Met Glu Leu Glu Ala Val Pro His Pro Ser Val 
            420                 425                 430         


Leu Val Ile Glu Lys Phe Ala Pro Gly Met Asn Ile Thr Leu Glu Thr 
        435                 440                 445             


Thr Gly Glu Arg Gly Glu Met Asp Leu Asp Leu Leu Gly Gly Ile Ser 
    450                 455                 460                 


Ser Gly Trp Arg Lys Phe Trp Lys Tyr Thr Thr Ala Phe Ile Ile Ser 
465                 470                 475                 480 


Ile Leu Leu Leu Tyr Leu Ile Tyr Phe Ala Leu Lys Phe Phe Lys Ile 
                485                 490                 495     


Leu Lys Thr Pro Arg Thr Glu Arg Pro Glu Thr Met Gln Met Gln Gly 
            500                 505                 510         


Phe Tyr 
        


<210>  543
<211>  568
<212>  PRT
<213>  Garba sunrhavirus

<400>  543

Met Lys Leu Leu Ile Ile Glu Phe Phe Ala Ile Ile Thr Ser Phe Phe 
1               5                   10                  15      


Ala Ser Arg Cys Leu Ser Leu Glu Tyr Met Tyr Phe Pro Thr Ser Val 
            20                  25                  30          


Thr Lys Gly Phe Thr Pro Ile His Leu Asp His Leu Asn Cys Pro Tyr 
        35                  40                  45              


Asp Ile Asp Asp Thr Glu Ile Glu Asn Pro Val Glu Val Asp Cys Lys 
    50                  55                  60                  


Ile Leu Val Thr Asn Leu Ile Asp Val Glu Gly Glu Val Cys Tyr Lys 
65                  70                  75                  80  


Gln Lys Trp Val Thr Asn Cys Tyr Glu Asn Phe Ile Gly Gln Gln Thr 
                85                  90                  95      


Ile Asn His Arg Ile His His Leu Pro Ile Ser Ala Asp Asp Ile Val 
            100                 105                 110         


His Lys Leu Ser Leu Asp Ser Asn Leu Val Pro Pro Asp Ala Asn Cys 
        115                 120                 125             


Gln Trp Met Ser Asp Thr Glu Thr Glu Asp Thr Lys Val Ile Cys Gln 
    130                 135                 140                 


Pro Val Thr Ile Lys Tyr Asp Glu Thr Leu Asn Leu Gly Ser His Pro 
145                 150                 155                 160 


Ser Leu Gly Thr Phe Pro Cys Val Lys Pro Pro Cys Ser Ile Asp Lys 
                165                 170                 175     


Gln His Val Phe Asn Ser Thr Asp Phe Thr Ala Thr Asn Lys Gly Tyr 
            180                 185                 190         


Lys Asp Thr Lys Val Gln Phe Ser Thr Asp Gln Asn Gly His Ile Tyr 
        195                 200                 205             


Glu Thr Ser Phe Val Lys Ser Asp Val Phe Pro Lys Met Ser Leu Glu 
    210                 215                 220                 


Gly Ala Cys Ile Glu Met Thr Lys Ser Ala Ser Asn Asn Asn His Ala 
225                 230                 235                 240 


Ala Lys Ile Ile Leu Gln Ser Gly Leu Leu Leu Glu Val Arg Asp Ala 
                245                 250                 255     


Phe Asp Leu Gly Ser Asp Asp Ser Tyr Ala Thr Gly Asn Ser Ile His 
            260                 265                 270         


Val Asn His Asn Leu Ala Glu Leu Lys Lys Leu Leu Leu Lys Lys Ser 
        275                 280                 285             


Lys Lys Asn Ser Thr Trp Gly Gln Val Met Phe Asp Gln Asn Ser Arg 
    290                 295                 300                 


Ser Lys Met Thr Phe Ser Ser Asp Val Thr Gly Lys Phe Lys Gln Phe 
305                 310                 315                 320 


Gly Lys Leu Phe Val Asp Leu Arg Ile Cys Gln Lys Asn Asp Phe Lys 
                325                 330                 335     


Arg Val Val Val Pro Thr Leu Asp Phe Gln Arg Ser Met Thr Glu Met 
            340                 345                 350         


Phe Val Glu Ser Lys Ile Asp Gln Leu Ser Cys Lys Lys Arg Leu Tyr 
        355                 360                 365             


Glu Ile Met Ser Thr Gly Ser Ile Thr Gly Ala Asp Leu Gly Leu Leu 
    370                 375                 380                 


Ser Gln Asn His Glu Gly Pro Gly Pro Val Tyr Gln Leu Tyr Lys His 
385                 390                 395                 400 


Asp Val Thr Met Ala Tyr Gly Thr Tyr Glu Arg Phe Thr Trp Met Pro 
                405                 410                 415     


Lys Thr Glu Gly Gly Lys Gln Tyr Leu Gly Tyr Val His Ile Gly Asn 
            420                 425                 430         


Thr Lys Lys Trp Val Glu Cys Pro Glu Trp Val Pro Asp Ser Glu Ser 
        435                 440                 445             


Thr Asp Ile Lys Trp Cys Val Asn Gly Ile Phe Glu Arg Asn Gly Ser 
    450                 455                 460                 


Leu Tyr His Pro Val Phe Gly Gly Asp Asn Ile Arg Asp Leu Lys Val 
465                 470                 475                 480 


Ala Tyr Gln Val Arg Asn Leu Arg Lys Val Glu His Leu Ser Leu Leu 
                485                 490                 495     


Leu Gln Thr Asn Asn Arg Thr Ile Ser Asn Trp Glu Glu Tyr Phe Lys 
            500                 505                 510         


Leu Glu Ser Lys His Thr Phe Glu Gly Trp Asn Arg Val Ser His Trp 
        515                 520                 525             


Phe Lys Gly Leu Ser Asp Glu Ile Lys Tyr Ile Phe Tyr Gly Leu Ser 
    530                 535                 540                 


Phe Val Phe Val Leu Phe Cys Ile Val Arg Leu Leu Arg Trp Arg His 
545                 550                 555                 560 


Arg Ser Gln Leu Tyr Leu Asp Tyr 
                565             


<210>  544
<211>  534
<212>  PRT
<213>  Kwatta sunrhavirus

<400>  544

Met Asp Lys Leu Ile Ile Leu Thr Ala Cys Leu Leu Gly Val Val Ile 
1               5                   10                  15      


Ala Ser His Asp Tyr Tyr Tyr Phe Pro Val Val Gln Ser Lys Ser Phe 
            20                  25                  30          


Lys Lys Leu Pro Val Gly Gln Leu Arg Cys Pro Pro His Ser Ser Glu 
        35                  40                  45              


Lys Pro Leu Ser His Lys Lys Ile Trp Gly Gly Tyr Val Leu Thr Gln 
    50                  55                  60                  


Asn Ile Gln Thr Met Pro Gly Thr Phe Val Val Lys Gln Arg Trp Gly 
65                  70                  75                  80  


Thr Thr Cys Thr Met Asn Phe Trp Gly Val Lys Thr Ile Arg His His 
                85                  90                  95      


Ile Ile Asp Glu Gln Ile Leu Asp Ala Arg Phe Thr Asn Ile Thr Leu 
            100                 105                 110         


Lys Pro Val Phe Pro Asp Glu Asp Cys Ser Trp Met Thr Thr Ala Thr 
        115                 120                 125             


Arg Glu Ile Thr Tyr Tyr Val Gly Thr Lys Gly Glu Leu Glu Tyr Asp 
    130                 135                 140                 


Ile Ser Thr Gly Lys Thr Ser Asp Pro Val Phe Gly Ala Phe Ser Cys 
145                 150                 155                 160 


Thr Glu Lys Leu Cys Tyr Val Asp His Arg Val Val Phe Ile Pro Asp 
                165                 170                 175     


Val Ala Ile Ala Ala Thr Ser Lys Gly Phe Lys Phe Val Val Phe Glu 
            180                 185                 190         


Ile Ser Thr Asp Pro Asp Gly Val Ile Arg Glu Asn Ser Val Ile Gln 
        195                 200                 205             


Ser Arg Asp Phe Pro Arg Met Ser Leu Arg Lys Ala Cys Val Thr Glu 
    210                 215                 220                 


Glu Ser Val Leu Gly Gln Arg Arg Leu Ala Phe Ile Leu Arg Asn Gly 
225                 230                 235                 240 


Phe Phe Leu Val Leu Glu Met Gly Val Lys Ser Gly Ser His Met Leu 
                245                 250                 255     


Lys Lys Ser Thr Glu Thr Leu Gly Ser Glu Leu Ile Leu Arg Ala Ser 
            260                 265                 270         


Leu Arg Leu Ser Asn Asp Lys Phe Lys Gly Arg Asp Leu Ser Met Leu 
        275                 280                 285             


Tyr Thr Gln Glu Lys Ile Ser Gly Ala Gly Ser Ile Asp Asn Leu Leu 
    290                 295                 300                 


Asn Gly Phe Arg Val Cys Asp Ala Ser Asp Arg Ser Arg Ile Lys Gln 
305                 310                 315                 320 


Val Gly Leu Gly Phe Asn Ser Leu Glu Gln Asp Glu Arg Ile Met Ser 
                325                 330                 335     


Arg Val Asp Ser Leu Phe Cys Arg Val Thr Leu Asp Arg Ile Arg Lys 
            340                 345                 350         


Cys Lys Lys Leu Thr Ser Val Glu Leu Gly Met Phe Ala Gln Asn Tyr 
        355                 360                 365             


Gly Gly Pro Gly Pro Val Tyr Arg Ile Lys Asn Asp Thr Leu Glu Val 
    370                 375                 380                 


Ala Gln Gly Ile Tyr Lys Arg Ile Phe Trp Asp Pro Asp Thr Lys Asn 
385                 390                 395                 400 


Arg Leu Gly Tyr Tyr Val Asn Glu Thr Thr Glu Lys Glu Val Asn Cys 
                405                 410                 415     


Pro Glu Trp Ile Lys Ile Ser Glu Gly Phe Glu Ser Cys Ile Asn Gly 
            420                 425                 430         


Ile Ile Arg Tyr Lys Asn Val Thr Ser His Pro Leu Ser Pro Val Asn 
        435                 440                 445             


Asp Leu Glu Gln Glu Glu Ala Leu Phe Lys Glu His Phe Leu Glu Asp 
    450                 455                 460                 


Val Tyr His Val Pro Thr Gln His Leu Asn Pro Trp Ala Gly Trp Asn 
465                 470                 475                 480 


Pro Leu His Pro Pro Glu Ile Asp Arg His Phe Leu Gly Leu Lys Leu 
                485                 490                 495     


Pro Asn Ile Phe Gly Phe Met His Asn Phe Glu Ile Tyr Leu Val Thr 
            500                 505                 510         


Phe Ile Val Gly Leu Ile Ser Leu Pro Leu Ile Ile Phe Cys Cys Arg 
        515                 520                 525             


Arg Lys Ser Ser Arg Tyr 
    530                 


<210>  545
<211>  567
<212>  PRT
<213>  Sunguru sunrhavirus

<400>  545

Met Ser Leu Leu Gly Leu Ala Val Val Ser Phe Ile Ser Ile Leu Ser 
1               5                   10                  15      


Asn Val Gly Ser Val Glu His Leu Tyr Phe Pro Val Glu Met Lys Ser 
            20                  25                  30          


Gln Phe Lys Pro Val Lys Leu Glu Asp Leu Thr Cys Pro Tyr Ala Ser 
        35                  40                  45              


Asp Asp Met Gly Phe Pro Ser Ser Val Lys Ala Asp Val Gln Leu Leu 
    50                  55                  60                  


Lys Thr Asn Leu Ile Arg Val Pro Gly Thr Ile Cys Tyr Arg Gln Leu 
65                  70                  75                  80  


Trp Thr Ile Lys Cys Ser Glu Asn Phe Phe Gly Val Gln Thr Ile Asn 
                85                  90                  95      


Lys Asp Ile Lys Asp Leu Glu Leu Gly His Phe Pro Glu Lys Gly Asp 
            100                 105                 110         


Asp Lys Val Tyr Phe Pro Asp Pro Thr Cys Arg Trp Met Ser Glu Ser 
        115                 120                 125             


Glu Thr Thr Ala Glu Phe Ala Ile Cys Lys Asp Glu Glu Ile Leu Phe 
    130                 135                 140                 


Asp Glu Thr Thr Gly Leu Gly Thr Asp Asn Gln Tyr Gly Ser Phe Phe 
145                 150                 155                 160 


Cys Gln Lys Asp Tyr Cys Pro Ile Asn Lys Tyr Val Gly Phe Lys Pro 
                165                 170                 175     


Lys Arg Pro Leu Ala Glu Ile Ile Lys Glu Gly Phe Met Asp Ile Glu 
            180                 185                 190         


Ala Glu Phe Ser Val Asn Ser Arg Gly Phe Val Asp Ile His Ser Leu 
        195                 200                 205             


Thr Arg Ser His His Tyr Pro Arg Met Ser Met Lys Asn Ala Cys Val 
    210                 215                 220                 


Arg Trp Arg Asp His Glu Ser Lys Lys Lys Phe Asp Leu Ile Leu Asn 
225                 230                 235                 240 


Asn Gly Phe Leu Ile Arg Phe Lys Ser Glu Phe Asp Ile Glu Val Ser 
                245                 250                 255     


Pro Arg Leu Glu Ser Asn Trp Val Thr Lys Asp Tyr Asn Thr Asp Asp 
            260                 265                 270         


Glu Val Lys Lys Leu Ile Asn Ala Lys Ser His Pro Asn His Gly Thr 
        275                 280                 285             


His Phe Ser Phe Gln Arg Asp Pro Trp Ala Lys Ile Ser Asp Ser Val 
    290                 295                 300                 


Ile Lys Lys Glu Lys Phe Lys Phe Ala His Leu Ile Leu Ser Leu Arg 
305                 310                 315                 320 


Asn Cys Glu Lys Glu Asp Asp Lys Arg Ile Lys Ile Pro Tyr Ile Asp 
                325                 330                 335     


Phe Gln Thr Thr Asp Val Glu Met Tyr Ile Glu Ser Lys Ile Asp Gln 
            340                 345                 350         


Ile Ala Cys Lys Arg Arg Leu Tyr Glu Ile Ile Thr Glu Lys Lys Phe 
        355                 360                 365             


Asn Leu Ile Asp Leu Gly Leu Leu Ala Pro Asn His Gly Gly Leu Gly 
    370                 375                 380                 


Pro Val Tyr His Ser Tyr Ser Lys Asp Ile Ser Arg Gly Phe Gly His 
385                 390                 395                 400 


Tyr Arg Arg Ile Ile Trp Asp Pro Gln Pro Glu Ile Gly Ile Leu Gly 
                405                 410                 415     


Tyr Tyr Phe Asp Gly Gly Glu Gln Lys Asn Val Thr Cys Pro Glu Trp 
            420                 425                 430         


Val Arg Lys Asn His Ser Leu Ser Trp Cys Val Asn Gly Ile Phe Lys 
        435                 440                 445             


Met Gly Gly Lys Ile Phe His Pro Ile Tyr Gly Ala Asp Asn Leu Glu 
    450                 455                 460                 


Glu Leu Lys Ile Ala Phe Glu Glu Arg Asp Val Arg Ser Val Glu His 
465                 470                 475                 480 


Pro Ala Ile Leu His Asp Leu His Asn Arg Glu Ala Thr Thr Trp Lys 
                485                 490                 495     


Glu Tyr His Lys Val Thr Asp Asp Leu Arg Trp Lys Gly Val Asn Leu 
            500                 505                 510         


Gly Ile Trp Asp Phe Phe Asp Ser Val Ile Gly Lys Ile Val Ala Cys 
        515                 520                 525             


Ala Leu Gly Gly Leu Met Phe Leu Ile Leu Phe Trp Val Ser Ala Ser 
    530                 535                 540                 


Val Ile Met Arg Cys Cys Val Lys Arg Ser Phe His Asn Pro Asn Ala 
545                 550                 555                 560 


Lys Arg Arg Ser Glu Glu Trp 
                565         


<210>  546
<211>  538
<212>  PRT
<213>  Walkabout sunrhavirus

<400>  546

Met Lys Ser Gln Phe Lys Pro Val Lys Ile Glu Asp Leu Ser Cys Pro 
1               5                   10                  15      


Tyr Asn Gln Phe Glu Arg Asp His Thr Ser Asp Leu Lys Ile Asp Val 
            20                  25                  30          


Glu Leu Leu Lys Asn Asn Leu Ile Thr Lys Thr Gly Asn Leu Cys Tyr 
        35                  40                  45              


Lys Gln Arg Trp Ser Thr Lys Cys Glu Glu Asn Phe Phe Gly Ile Gln 
    50                  55                  60                  


Lys Leu Asn His Ser Ile Ile Asp Leu Pro Leu Asp Glu His Pro Ser 
65                  70                  75                  80  


Ser Ser Asp Ser Asn Pro Leu Phe Pro Pro Pro Asp Cys Arg Trp Met 
                85                  90                  95      


Ser Ser Ser Glu Val Ser Lys Asp Tyr Thr Ile Cys Lys Gln Glu Thr 
            100                 105                 110         


Ile Arg Phe Asp Glu Thr Leu Gly Ile Gly Val Asp Glu Gln Tyr Gly 
        115                 120                 125             


Thr Phe Lys Cys Glu Lys Ser Tyr Cys Arg Leu Asp Lys Tyr Ile Thr 
    130                 135                 140                 


Phe Leu Pro Ile Gly Gly Val Pro Gln Met Arg Leu Glu Gly Phe Glu 
145                 150                 155                 160 


Lys Val Lys Ser Tyr Ile Thr Leu Asp Gln Glu Gly Phe Val Thr Pro 
                165                 170                 175     


Ser Ser Leu Ile Tyr Ser Asn His Phe Pro Lys Met Ser Leu Lys Glu 
            180                 185                 190         


Ser Cys Met Arg Trp Val Asp Lys Gly Asp Tyr Asn Tyr Asp Ile Glu 
        195                 200                 205             


Leu Ile Thr Asn Asn Gly Phe Leu Leu Arg Leu Pro Leu Asn Ile Asn 
    210                 215                 220                 


Leu Lys Ala Lys Ser Gly Ala Ile Leu Thr Pro Thr Ile Glu Asn Asn 
225                 230                 235                 240 


His Ile Ser His Thr Tyr His Ile Asn Asp Val Ile Glu Leu Leu Leu 
                245                 250                 255     


Ala Arg Ala Lys Gly Ile Gln Lys Glu Arg Lys Leu Phe Thr Phe Thr 
            260                 265                 270         


Arg Asn His Arg Trp Leu Lys Leu Ala Asp Asn Ser Lys Leu Glu Asp 
        275                 280                 285             


Lys Phe Ala Lys Lys Asp Thr Pro Phe Ile His Phe Phe Thr Met Ile 
    290                 295                 300                 


Arg Asp Cys Glu Glu Lys Asp Glu Lys Arg Ile Thr Val Pro Thr Met 
305                 310                 315                 320 


Asp Phe Gln Thr Ile Glu Ala Glu Met Phe Val Glu Ser Lys Ile Asp 
                325                 330                 335     


Gln Met Phe Cys Lys His Arg Leu Tyr Asp Ile Met Thr Lys Gly Lys 
            340                 345                 350         


Ala Ser Leu Asn Asp Leu Ala Leu Leu Ser Pro Asn His Gly Gly Leu 
        355                 360                 365             


Gly Pro Val Tyr His Arg Tyr Ala Asn Asp Ile Thr Arg Gly Ile Gly 
    370                 375                 380                 


Val Tyr Arg Arg Ile Asn Trp His Pro Ser Lys Glu Gly Leu Gly Tyr 
385                 390                 395                 400 


Tyr Phe Lys Asp Ser Lys Gln Val Trp Val Lys Cys Pro Glu Trp Val 
                405                 410                 415     


Asn Gly Thr Asp Gly Phe Arg Trp Cys Val Asn Gly Ile Phe Glu Leu 
            420                 425                 430         


Asn Gly Lys Val Tyr His Pro Tyr Phe Gly Ala Asp Asn Phe Gln Glu 
        435                 440                 445             


Leu Ile Lys Ser Phe Glu Glu Asp Glu Val Arg Arg Val Lys His Asn 
    450                 455                 460                 


Val Ile Leu His Asp Leu Gly Ser Arg Ser His Glu Thr Trp Glu Ser 
465                 470                 475                 480 


Tyr Leu Gly Ala Lys Glu Asn Tyr Thr Trp Lys Gly Phe Asn Leu Ser 
                485                 490                 495     


Trp Ile Asp Ser Ile Arg Lys Trp Ala Asn Asn Ser Trp Met Ile Val 
            500                 505                 510         


Val Gly Val Cys Ser Gly Leu Gly Ile Leu Leu Leu Ile Lys Ile Thr 
        515                 520                 525             


Arg Gly Lys Arg Ser Gly Gly Ala Asp Trp 
    530                 535             


<210>  547
<211>  629
<212>  PRT
<213>  Bas-Congo tibrovirus

<400>  547

Met Thr Arg Leu Ser His Ala Ile Thr Lys Leu Leu Leu Leu Phe Cys 
1               5                   10                  15      


Leu Thr Ala Ile His Ala Ile Val Ile Asn Tyr Pro Thr Ala Cys His 
            20                  25                  30          


Thr Tyr Gln Glu Val Leu Tyr Gln Gly Leu Glu Cys Pro Glu Pro Ala 
        35                  40                  45              


Ile Ser Tyr Lys Leu Asp Asn Asn Glu Thr Val Ala Tyr Gly Gln Ile 
    50                  55                  60                  


Cys Arg Pro Gln Leu Ala Ser Lys Asp Ile Leu Glu Gly Tyr Leu Cys 
65                  70                  75                  80  


Tyr Lys Asp Thr Tyr Ile Ser Ser Cys Glu Glu Thr Trp Tyr Phe Thr 
                85                  90                  95      


Ser Gln Val Lys Gln Thr Ile Val His Glu His Val Ser Asp Ala Glu 
            100                 105                 110         


Cys Ile Glu Ser Leu Ala Tyr Tyr Lys Ser Gly Ile Val Glu Thr Pro 
        115                 120                 125             


Met Phe Leu Asn Val Asp Cys Tyr Trp Asn Ala Ile Asn Ser Ile Lys 
    130                 135                 140                 


Lys Ser Tyr Leu Ile Ile Val Tyr His Pro Val Pro Phe Asp Pro Tyr 
145                 150                 155                 160 


Thr Asn Ser Ile Lys Asp Ala Val Val Lys Asn Ser Glu Asp Val Asn 
                165                 170                 175     


Ser Trp Ile Arg Asp Thr His Tyr Pro Phe Thr Lys Trp Ile Arg Asp 
            180                 185                 190         


Phe Asn Gly Thr Ala Glu Glu Lys Cys Asp Ala Gln His Trp Glu Cys 
        195                 200                 205             


Phe Lys Val Asn Leu Tyr Lys Gly Trp Ile Tyr Ser Pro Pro His Thr 
    210                 215                 220                 


Lys Asn Thr Ile Gly Ser Ser Thr Gln Thr Gly Leu Ile Leu Glu Ser 
225                 230                 235                 240 


Asp Ile Tyr Ser His Thr Leu Ile Arg Asp Leu Cys Arg Phe Gln Phe 
                245                 250                 255     


Cys Gly Ile His Gly Phe Val Phe Gln Asp Gln Ser Trp Trp Asp Leu 
            260                 265                 270         


Gln Leu Asn Val Ser Leu Ser Ser Leu Ile Ser Thr Glu His Leu Ser 
        275                 280                 285             


Gly Ala Pro Asp Gly His Cys Lys Lys Val Asn Glu Ile Gly His Ala 
    290                 295                 300                 


Glu Leu Glu Pro Asn Trp Glu Lys Ile Leu Ser Val Asp Asp Tyr Asp 
305                 310                 315                 320 


Ile Arg His Gln Leu Cys Leu Asp Thr Leu Ala Ser Val Leu Gly Gly 
                325                 330                 335     


Gly Phe Leu Thr Ala Arg Asp Leu Leu Lys Phe Ala Pro Met Arg Pro 
            340                 345                 350         


Gly Leu Gly Pro Ala Tyr Phe Leu Phe Asn Pro Asn Lys Arg Glu Arg 
        355                 360                 365             


Ala Val His Val Trp Thr Ala Gly Ala Thr Thr Ser Ser Ile Leu Trp 
    370                 375                 380                 


Lys Ser Thr Cys Lys Tyr Glu Leu Ile Asp Ile Pro Gln Leu Asn Asp 
385                 390                 395                 400 


Thr Gly Ile Ile Thr Tyr Glu Lys Leu Asp Asn Ile Ile Gly Lys Ile 
                405                 410                 415     


Leu Arg Asn Asp Val Gly Val Ser Phe Lys Asp Leu Gly Phe Thr Glu 
            420                 425                 430         


Asn Glu Leu Thr Asp Asp Asp Val Ser Gln Ser Gln Leu Asn Ser Ser 
        435                 440                 445             


Leu Gly Ile Tyr His Arg Asn Thr Ser Met Lys Gly Ile Pro Trp Lys 
    450                 455                 460                 


Arg His Arg Ala Ser Thr Pro Lys Leu Lys Met Gly Pro Asn Gly Ile 
465                 470                 475                 480 


Leu His Asp Leu Asn Ala Lys Ile Ile His Leu Pro Gln Ala Ser Ser 
                485                 490                 495     


Ser Val Phe Lys Leu Pro Pro His Leu Tyr Glu Gly His Arg Val Val 
            500                 505                 510         


Phe Phe Asn His Ile Thr Lys Lys Lys Ile Tyr Glu Asp Leu Ser Lys 
        515                 520                 525             


Arg Glu Gly Asn Asp Pro Tyr Asn Val Asp Ile Gly Asp Leu Ile Gly 
    530                 535                 540                 


Arg His Leu Asn Arg Thr Thr Ile Pro Asp Gln Leu His Asp Trp Val 
545                 550                 555                 560 


Ser Gly Ile Lys Arg His Ile Phe Ser Val Phe Glu Gln Phe Gly Ser 
                565                 570                 575     


Leu Ile Lys Val Val Val Phe Ile Ile Met Leu Val Leu Cys Ile Lys 
            580                 585                 590         


Ile Ile Asn Leu Ile Tyr Arg Phe Tyr Lys Val Arg Lys Ser Asn His 
        595                 600                 605             


Lys Lys Leu Ala Ser Arg Lys Glu Lys Leu His Leu Ser Asp Pro Phe 
    610                 615                 620                 


Ser Val Asn Ser Lys 
625                 


<210>  548
<211>  659
<212>  PRT
<213>  Beatrice Hill tibrovirus

<400>  548

Met Phe Ile Lys Asn Leu Pro Val Ala Leu Ile Leu Asn Cys Leu Gly 
1               5                   10                  15      


Leu Thr Leu Ser Gln Leu Leu Tyr Asn Tyr Pro Phe Asn Cys Asn Pro 
            20                  25                  30          


Gly Pro Glu Met Thr Leu Asp Gly Leu Thr Cys Pro Leu Asp Phe Asn 
        35                  40                  45              


Thr Phe Asn Leu Asp Asn Lys Asp Thr Ile Glu Ala Gly Thr Met Cys 
    50                  55                  60                  


Arg Pro Asn Pro Leu Ser Lys Asp Val Glu Asp Gly Phe Leu Cys Tyr 
65                  70                  75                  80  


Lys Asp Thr Trp Val Thr Ala Cys Glu Glu Thr Trp Tyr Phe Ser Lys 
                85                  90                  95      


Thr Val Lys Asn His Ile Ile His Glu His Ile Thr Lys Asp Glu Cys 
            100                 105                 110         


Val Glu Ala Leu Ala Thr Tyr Lys Leu Gly Lys His Val Glu Pro Phe 
        115                 120                 125             


Phe Pro Ala Pro Ser Cys Tyr Trp Ser Ala Val Asn Glu Glu Arg Ala 
    130                 135                 140                 


Thr Phe Ile Asn Ile Gln Pro His Gly Val Ile Leu Asp Pro Tyr Ser 
145                 150                 155                 160 


Gly Lys Ile Lys Asp Pro Leu Ile Asp Pro Glu Thr Cys Asp Asn Asp 
                165                 170                 175     


Phe Cys Ile Thr Arg Ser His Gln Thr His Trp Leu Arg Asn Leu Lys 
            180                 185                 190         


Pro Asp Ile Met Glu Arg Cys Asn Asn Glu Thr Trp Glu Cys His Pro 
        195                 200                 205             


Ile Asn Ile Tyr Tyr Gly Trp Val Ser Lys Arg Lys Ile Gln Glu Thr 
    210                 215                 220                 


Ser Thr Thr Phe Asn Tyr Val Gln Thr Gly Leu Val Ile Glu Ser Gln 
225                 230                 235                 240 


Tyr Ile Gly His Ile Leu Met Thr Asp Leu Cys His Met Lys Phe Cys 
                245                 250                 255     


Gly Arg Asp Gly Tyr Leu Phe Pro Asp Gly Ser Trp Trp Glu Ile Lys 
            260                 265                 270         


Tyr Ser Val Leu His Ala Leu Thr Lys Asp His Thr Ile Leu His Asn 
        275                 280                 285             


Val Tyr Asn Cys Asp Asp Arg Thr His Gly Asp Tyr Leu Thr Asp Val 
    290                 295                 300                 


Gln Lys Ser Lys Lys Val Gly Tyr Glu Asp Leu Glu Ile Asn Leu Glu 
305                 310                 315                 320 


Gly Leu Glu Met Arg Gln Lys Ser Arg Ser Ile Asn Met Met Cys Leu 
                325                 330                 335     


Asn Arg Leu Ala Glu Ile Arg Asn Thr His His Ile Asn Val Leu Asp 
            340                 345                 350         


Met Ser Tyr Leu Thr Pro Lys His Pro Gly Lys Gly Leu Ala Tyr Tyr 
        355                 360                 365             


Phe Ser Gln Asp His Asn Asn Ala Ser Lys Tyr Tyr Val Lys Thr Leu 
    370                 375                 380                 


Lys Cys Asp Tyr Lys Leu Ile His Ile His Asp Ala Asp Ile Arg Gly 
385                 390                 395                 400 


Phe Val Asn Ile Ser Lys Tyr Pro Glu Pro Asn Val Thr Ile Leu Gly 
                405                 410                 415     


Leu Gln Asp Asn Leu Thr Phe Ala Asn Leu Gly Ile Ala Arg Cys His 
            420                 425                 430         


Asp Phe Thr Gln Leu Asn Asp Ser Arg Asn Val Ser Cys Glu Asp Ser 
        435                 440                 445             


Pro Gly Pro Phe Phe Asn Asn Asn Ser Arg Leu Ser Asn Gly Lys Arg 
    450                 455                 460                 


Phe Trp Thr Arg His Ser Phe Gly Gly Ala Asn Phe His Glu His Pro 
465                 470                 475                 480 


Gly Val Arg Ile Gly Val Asn Gly Ile Met Tyr Asp Leu Lys Lys Gln 
                485                 490                 495     


Ile Leu Arg Phe Pro Ser Thr Ser Asn Leu Leu Trp Asp Leu Pro Ser 
            500                 505                 510         


Tyr Tyr Ser Thr Lys His Lys Val His Phe Phe Lys His Pro Thr Lys 
        515                 520                 525             


His Asn Ile Arg Lys Asn Phe Thr Gly Ser Asp Lys Gln Asp Ile Asp 
    530                 535                 540                 


Val Leu Asp Asp Leu Ile Asn Arg His Ile Asn Arg Thr Asp Phe Pro 
545                 550                 555                 560 


Thr Arg Ile Arg Asn Trp Ile Gly Asn Ile Glu Asp Thr Val Glu His 
                565                 570                 575     


Phe Phe Ser Asn Val Gly Gly Thr Ile Lys Thr Met Ile Ser Leu Ala 
            580                 585                 590         


Leu Phe Ile Ile Gly Thr Leu Val Ser Ile Lys Ile Trp Arg Lys Cys 
        595                 600                 605             


Arg Lys Gln Pro Lys Asn Thr Pro Ile Ile Lys Gln Ile Lys Leu Asn 
    610                 615                 620                 


Asp Tyr Glu Lys Pro His Ser Arg Ala Glu Gln Thr Gln Asp Ala Asn 
625                 630                 635                 640 


Glu Asp Leu Tyr Glu Asn Ile Glu Thr Arg Gly Glu Ile Tyr Ser Pro 
                645                 650                 655     


Phe His Val 
            


<210>  549
<211>  658
<212>  PRT
<213>  Coastal Plains tibrovirus

<400>  549

Met Ser Ser Arg Ile Leu Ser Val Ile Asn Leu Ile Ala Met Phe Ile 
1               5                   10                  15      


Ser Ala Ser Leu Ser Gln Leu Ile Tyr Asn Tyr Pro Phe Asn Cys Lys 
            20                  25                  30          


Gln Glu Ile Asn Leu Leu Pro Phe Asp Ser Ile Gln Cys Pro Met Asp 
        35                  40                  45              


Tyr Asn Thr Phe Asn Leu Lys Ser Arg Ser Ser Val Glu Glu Gly Thr 
    50                  55                  60                  


Met Cys Arg Pro Asn Pro Leu Ala Thr Asp Leu Glu Glu Gly Tyr Met 
65                  70                  75                  80  


Cys Tyr Lys Asp Arg Trp Val Thr Arg Cys Glu Glu Asn Trp Tyr Phe 
                85                  90                  95      


Ser Lys Thr Val Thr Asn His Ile Val His Glu Pro Val Ser Lys Asp 
            100                 105                 110         


Glu Cys Val Glu Ala Leu Ala Leu Phe Lys Met Gly Gln Thr Lys Asp 
        115                 120                 125             


Pro Phe Phe Pro Ala Pro Ser Cys Tyr Trp Ser Ala Ala Asn Glu Glu 
    130                 135                 140                 


Ser Val Thr Phe Leu Met Ile Lys Lys His Pro Val Val Ile Asp Pro 
145                 150                 155                 160 


Tyr Ser Gly Lys Ile Lys Asp Pro Leu Ile Asp Asn Asp Leu Cys Lys 
                165                 170                 175     


Asp Gly Phe Cys Lys Thr Arg Ala His Gln Thr His Trp Met Arg Asp 
            180                 185                 190         


Tyr Lys Thr Asp Ile Val Glu Arg Cys Asp Asp Lys Thr Trp Glu Cys 
        195                 200                 205             


His Pro Ile Lys Val Tyr Tyr Gly Trp Val Pro Lys Ile Lys Asn Gly 
    210                 215                 220                 


Thr Ser Ser Val Thr Thr Ser Tyr Val Glu Thr Gly Leu Val Ile Glu 
225                 230                 235                 240 


Ser Gln Tyr Leu Gly His Val Leu Val Thr Asp Leu Cys Gln Lys Thr 
                245                 250                 255     


Phe Cys Gln Gln Asp Gly Tyr Leu Phe Pro Asp Gly Ser Trp Trp Gln 
            260                 265                 270         


Ile Lys Ile Ser Leu Thr Lys Leu Leu Leu Lys Asn His Asn Ala Leu 
        275                 280                 285             


Glu Lys Ala Lys Thr Cys Gly Asp Arg Asp His Gly Ser Glu Leu Thr 
    290                 295                 300                 


Asp Glu Gln Arg Ser Gly Lys Ile Gly Phe Glu Asp Leu Glu Ile Asn 
305                 310                 315                 320 


Leu Glu Asn Ile Glu Met Lys Gln Lys Ser Gln Thr Leu Asn Leu Met 
                325                 330                 335     


Cys Leu Glu Lys Val Ala Lys Met Arg Asn Ser Gln Ser Val Asn Phe 
            340                 345                 350         


Leu Asp Ile Ser Tyr Leu Thr Pro Lys Lys Pro Gly Pro Gly Leu Ala 
        355                 360                 365             


Tyr Tyr Ile Val Glu Glu Pro Leu Met Ser Gly Gln Thr Lys Val Lys 
    370                 375                 380                 


Val Ser Asn Cys Gln Tyr Lys Phe Val Glu Ile Leu Gly Ser Asp Lys 
385                 390                 395                 400 


Ser Gly Ile Val Asn Val Thr Glu Ile Gly Ser Gln Gln Ile Phe Lys 
                405                 410                 415     


Leu Leu Glu Thr Gly Gln Val Phe Asn Met Ser Glu Leu Gly Ile Pro 
            420                 425                 430         


Ile Cys Glu Asp His Thr Gln Asp Asn Glu Thr Arg Asn Ile Thr Cys 
        435                 440                 445             


Glu Thr Asp Phe Gly Ile Ser Ala Asn Arg Gly Val Lys Gly Leu Ser 
    450                 455                 460                 


Gly Lys Pro Leu Trp Thr Val Arg Ser Phe Lys Gly Ser Asn Ile Ser 
465                 470                 475                 480 


Asn Leu Arg Gly Leu Arg Ile Gly Ser Asn Gly Ile Thr Tyr Asp Met 
                485                 490                 495     


Thr Lys Lys Ile Leu Arg Phe Pro Gln Ala Gly Asn Met His Trp Asp 
            500                 505                 510         


Ile Pro Ser Tyr Tyr Ser Thr Glu His Lys Val His Phe Phe Gln His 
        515                 520                 525             


Pro Thr Lys His Glu Ile Tyr Lys Asn Phe Thr Gly Asp Lys Lys Ser 
    530                 535                 540                 


Asp Ile Asp Phe Leu Glu Asp Leu Ile His Arg Lys Leu Asn Arg Thr 
545                 550                 555                 560 


Asp Phe Pro Thr Arg Ile Lys Asn Trp Ile Gly Asn Ile Glu Asp Lys 
                565                 570                 575     


Val Glu His Phe Phe Thr Asn Leu Ser Gly Thr Val Arg Thr Ala Ile 
            580                 585                 590         


Ser Leu Val Ile Phe Val Ile Gly Thr Leu Leu Ser Ile Lys Val Trp 
        595                 600                 605             


Arg Arg Cys Lys Lys Gln Lys Pro Lys Thr Arg Lys Ile Asp Arg Ser 
    610                 615                 620                 


Asn Gln Ala Lys Glu Glu Asn Ser Phe Ala Leu Asp Leu His Gln Asn 
625                 630                 635                 640 


Val Tyr Glu Asp Ile Glu Pro Asn Met Arg Gly His Asn Pro Phe His 
                645                 650                 655     


Arg Ser 
        


<210>  550
<211>  685
<212>  PRT
<213>  Ekpoma 1 tibrovirus

<400>  550

Met Lys Lys Thr Thr Arg Arg Ser Ser Ser Glu Thr Met Ile Leu Leu 
1               5                   10                  15      


Ile His Leu Pro Val Ile Leu Thr Thr Leu Thr Lys Leu Ile Ser Gly 
            20                  25                  30          


Asp Leu Ile Asn Phe Pro Phe His Cys Thr Asn Leu Glu Asn Ile Lys 
        35                  40                  45              


Tyr Ser Asn Leu Ser Cys Pro Thr Val Trp Glu Thr Phe Lys Ile Lys 
    50                  55                  60                  


Thr Gly Asp Lys Val Glu Arg Gly Ser Met Cys Arg Pro Ser Leu His 
65                  70                  75                  80  


Thr His Asp Leu Glu Glu Gly Tyr Leu Cys Tyr Lys Asp Thr Trp Thr 
                85                  90                  95      


Thr Thr Cys Asp Glu Ser Trp Tyr Phe Ser Thr Glu Val Lys Tyr Lys 
            100                 105                 110         


Ile Ile His Glu Glu Val His Asp Ile Asp Cys Leu Asp Ala Leu Ile 
        115                 120                 125             


Glu Tyr Lys Val Gly Lys Leu Lys Ala Pro Phe Phe Pro Val Ala Thr 
    130                 135                 140                 


Cys Tyr Trp Ala Ser Ser Thr Thr Glu Ser Ile Thr Phe Met Met Ile 
145                 150                 155                 160 


Lys Pro His Asn Ala Pro Leu Asp Pro Tyr Ser Asn Arg Ile Val Asp 
                165                 170                 175     


Pro Ile Ile Gln Ala Asp Ser Gly Asp Asn Leu Lys Ile Tyr Arg Thr 
            180                 185                 190         


Thr Phe Pro Lys Thr Arg Trp Ile Arg Glu Val Asn Thr Thr Leu Glu 
        195                 200                 205             


Glu Arg Cys Asn Val Ala Thr Trp Glu Cys His Asp Met Thr Leu Tyr 
    210                 215                 220                 


Ser Gly Trp Leu Thr His Pro Ser Gly Ala Phe Lys Thr Ser Leu Arg 
225                 230                 235                 240 


Thr Gly Leu Val Val Asp Ser Gln Ile Met Gly His Ile Leu Leu Arg 
                245                 250                 255     


Asp Thr Cys Lys Met Asp Phe Cys Gly Arg Arg Gly Phe Arg Phe Pro 
            260                 265                 270         


Asp Gly Gly Trp Trp Arg Leu Thr Thr Glu Asn Glu Val Ser Leu Gln 
        275                 280                 285             


Asp Phe Glu Leu Asn Asp Thr Val Val Pro Lys Cys Asp Asp Arg Ser 
    290                 295                 300                 


Arg Asn His Val Gly Tyr Thr Asp Leu Asp Tyr Asn Pro Glu Lys Ile 
305                 310                 315                 320 


Ala Leu Glu Gln Lys Ser Leu Leu Lys Thr Thr Met Cys Arg Glu Lys 
                325                 330                 335     


Leu Ala Glu Leu Gly Gln Gly Lys Gly Met Ser Leu Tyr Asp Thr Thr 
            340                 345                 350         


Tyr Leu Ile Pro Asn Ala Pro Gly Arg Tyr Pro Ala Tyr Tyr Ile Tyr 
        355                 360                 365             


Pro Val Gly Leu Asn Lys Thr Leu Glu Thr Gln Ile Leu Lys Glu Lys 
    370                 375                 380                 


Thr Ile Ser Asn Pro Leu Thr Ala Lys Arg Lys Glu His Met Pro Ile 
385                 390                 395                 400 


Met Leu Tyr Met Ala Gln Cys His Tyr Thr Leu Ile Glu Phe Pro Asn 
                405                 410                 415     


Leu Asp Ser Thr Gly Thr Leu Arg Tyr Thr Ser Leu Glu Asp Pro Val 
            420                 425                 430         


Gly Thr Ile Leu Glu Ser Gly Lys Asn Val Ser Leu Ala Asp Leu Gly 
        435                 440                 445             


Phe Glu Asp Ile Asn Leu Asp Asn Thr Thr Cys Lys Gly Asn Asp Ser 
    450                 455                 460                 


Asp Cys Phe Asn Thr Thr Thr Pro Lys Glu Pro Leu Leu Asp Arg Lys 
465                 470                 475                 480 


Phe Asn Met Thr Asn His Thr Leu Pro Trp Arg Arg Tyr Ser Lys Arg 
                485                 490                 495     


Glu Leu His His Arg Val Thr Tyr Asn Gly Ile Thr His Ser Pro Val 
            500                 505                 510         


Gly His Trp Val Gln Ile Pro Tyr Gly Ala Ser Leu Thr Ala Asn Leu 
        515                 520                 525             


Pro Glu His Leu Ile Glu Lys His Ser Thr His Phe Phe Asp His Val 
    530                 535                 540                 


Thr Lys Gln Ser Ile Phe Glu Arg Glu Leu Gln Asn Gly Glu Ile Ser 
545                 550                 555                 560 


Ile Asp Asp Leu Glu Gln Leu Ile Gly Arg Lys Thr Asn His Thr Asp 
                565                 570                 575     


Leu Pro Lys Lys Val Arg Asn Trp Val Gln Asn Ala Lys Glu Ser Val 
            580                 585                 590         


Val Gly Ile Phe Arg Glu Phe Gly His Thr Ile Arg Leu Gly Leu Ser 
        595                 600                 605             


Ile Val Ser Phe Leu Ile Gly Leu Ile Ile Ser Phe Lys Val Trp Lys 
    610                 615                 620                 


Lys Cys Arg Lys Asn Lys Lys Glu Thr Gln Gln Gln Ser Arg Ser Ser 
625                 630                 635                 640 


Pro Ile Tyr Arg Pro Gln Asn Ile Tyr Glu Leu Glu Glu Gly Pro Ile 
                645                 650                 655     


Ser Pro Pro Pro Leu Ala Arg Gln Arg Glu His Asp Asn Ser Asn Ile 
            660                 665                 670         


Phe Arg Lys Thr Asp Pro Arg Asn Pro Phe Tyr Ser Arg 
        675                 680                 685 


<210>  551
<211>  630
<212>  PRT
<213>  Ekpoma 2 tibrovirus

<400>  551

Met Gln Thr Met Lys Lys Thr His Leu Leu Ala Phe Thr Ile Phe Gly 
1               5                   10                  15      


Gln Ile Leu Leu Ala Ser Ser Leu Val Val Asn Leu Pro Leu Arg Cys 
            20                  25                  30          


Asn Gly Arg Lys Asp Leu Leu Val Asn Ser Leu Lys Cys Pro Leu Pro 
        35                  40                  45              


Ser Thr Glu Val Lys Val Asp Gly Lys Val Lys Val Tyr Glu Gly Asp 
    50                  55                  60                  


Ile Cys Arg Pro Gln Ile Asn Ala Lys Asp Val Glu Ala Gly Tyr Leu 
65                  70                  75                  80  


Cys His Lys Asp Ile Tyr Lys Ala Ile Cys Asp Glu Thr Trp Tyr Phe 
                85                  90                  95      


Ser Ala Thr Val Lys His Glu Ile Glu His Ala Pro Ile Ser Asp Ile 
            100                 105                 110         


Glu Cys Ile Glu Gly Leu Thr Glu Leu Lys Leu Gly Ile Val Pro Asn 
        115                 120                 125             


Pro Gln Phe Pro Ser Val Asp Cys Tyr Trp Asn Ala Arg Thr Glu Glu 
    130                 135                 140                 


Lys Arg Thr Tyr Ile Ile Leu Thr Gln His Asp Pro Ala Leu Asp Pro 
145                 150                 155                 160 


Tyr Ser Asn Lys Ile Lys Asp Asn Val Val Asp Pro Asp Cys Asp Phe 
                165                 170                 175     


Asn Leu Cys Lys Thr Asn Phe Ile Asn Thr Lys Trp Ile Arg Asp Lys 
            180                 185                 190         


Asn Thr Thr Glu Ile Glu Arg Cys Asp Ala Lys Asn Trp Asp Cys His 
        195                 200                 205             


Pro Tyr Lys Ile Tyr Gln Gly Trp Ile Ser Lys Ser Glu Met Ile Gly 
    210                 215                 220                 


Trp Gly Asp Pro Thr Gln Ser Tyr Ser Tyr Thr Gly Leu Val Leu Asp 
225                 230                 235                 240 


Ser His Ile Tyr Gly His Ile Pro Met Ser Lys Leu Cys His Lys Thr 
                245                 250                 255     


Phe Cys Gly Lys Glu Gly Tyr Leu Phe Pro Asp Lys Ser Trp Trp Gln 
            260                 265                 270         


Ile Arg Ser Lys Thr Pro Ala Ser Pro Leu Phe Arg Glu Leu Thr Leu 
        275                 280                 285             


Asn Gly Ser Arg Ser Ala Phe Pro Asp Cys Glu Thr Ile Lys Thr Tyr 
    290                 295                 300                 


Gly Tyr Ala Glu Val Glu Glu Asp Glu Ser Ser Glu Ile Ile Arg Glu 
305                 310                 315                 320 


Ser Ala Glu Ile Arg His Glu Met Cys Leu Glu Thr Leu Ser Thr Leu 
                325                 330                 335     


Ala Ser Gly Tyr Glu Ala Ser Phe Arg Asp Leu Met Lys Phe Ile Pro 
            340                 345                 350         


Gln Arg Pro Gly Pro Gly Lys Ala Tyr Ser Leu Asn Ser Asn Gly Lys 
        355                 360                 365             


Pro Ser Tyr Tyr Asn Tyr His Trp Ala Gly His Pro Ala Ser Ser Ala 
    370                 375                 380                 


Ser Ile Gln Glu Gln Asp Cys Tyr Tyr Tyr Leu Val Asp Ile Pro Lys 
385                 390                 395                 400 


Ile Gln Asp Asp Gly Ile Leu Asn Ile Thr Gly Ile Gly Asn Thr Asp 
                405                 410                 415     


Val Cys Gly Lys Leu Leu Val Asn Gly Ser Ser Met Thr Leu Asn Ser 
            420                 425                 430         


Leu Gly Phe Lys Ile Asp His His Tyr Asp Asp His Ile Val Glu Thr 
        435                 440                 445             


Gly Thr Asp Val His Asp Glu Met Asn Ile Lys Glu Arg Met Val Trp 
    450                 455                 460                 


Ile Lys Pro Asp Lys Ile His Pro Leu Leu Trp Val Gly Pro Asn Gly 
465                 470                 475                 480 


Ile Val Ile Asp His Gln His Lys Gln Ile His Phe Pro Val Phe Ser 
                485                 490                 495     


Arg Gly Val Asp Arg Ile Pro His Tyr Trp Thr Gln Lys His Arg Val 
            500                 505                 510         


Val Lys Tyr Arg His Ala Thr Gln Leu Lys Ile Tyr Lys Gln Tyr Leu 
        515                 520                 525             


Asp Asn Pro Glu Lys Ser Asn Pro Tyr Asp Phe Asn Ala Trp Thr Gly 
    530                 535                 540                 


Arg His Val Asn Arg Thr Glu Ile Pro Val Ala Ile Ser Asn Trp Phe 
545                 550                 555                 560 


Ser Gly Val Lys Asp Thr Val Phe Asp Lys Ile Ser Lys Ile Gly Ser 
                565                 570                 575     


Trp Leu Lys Trp Ser Phe Tyr Leu Cys Phe Ile Phe Val Leu Phe Lys 
            580                 585                 590         


Gly Gly Leu Leu Val Trp Asn Lys Tyr Lys Thr Leu Arg His Gln Thr 
        595                 600                 605             


Lys Arg Thr Pro Lys Gly Lys Asn Ser Gln Asp Pro Glu Lys Leu Asp 
    610                 615                 620                 


Ile Phe Gly Gln Thr Val 
625                 630 


<210>  552
<211>  662
<212>  PRT
<213>  Sweetwater Branch tibrovirus

<400>  552

Met Ala Leu Asn Lys Leu Ile Phe Val Ile Leu Ile Asn Glu Ile Ser 
1               5                   10                  15      


Thr Gln Leu Leu Tyr Asn Tyr Pro Phe Asn Cys Lys Asn Glu Val Lys 
            20                  25                  30          


Leu Thr Leu Asp Gly Leu Gln Cys Pro Leu Asp Tyr Asn Thr Phe Asn 
        35                  40                  45              


Leu Arg Ser Asp Glu Leu Ser Glu Val Gly Thr Met Cys Arg Pro Asn 
    50                  55                  60                  


Pro Leu Ala Lys Asp Leu Glu Asp Gly Phe Leu Cys Tyr Lys Asp Thr 
65                  70                  75                  80  


Trp Val Thr Lys Cys Ser Glu Ser Trp Tyr Phe Ser Lys Thr Ile Ser 
                85                  90                  95      


Asn His Ile Val His Glu Pro Ile Ser Lys Ser Glu Cys Ile Glu Ala 
            100                 105                 110         


Leu Ala Thr Tyr Lys Met Gly Lys His Val Glu Pro Phe Phe Pro Ala 
        115                 120                 125             


Pro Ser Cys Tyr Trp Ala Ala Asp Asn Glu Glu Thr Val Thr Phe Ile 
    130                 135                 140                 


Asn Ile Lys Glu His Pro Val Ile Leu Asp Pro Tyr Ser Gly Lys Ile 
145                 150                 155                 160 


Lys Asp Pro Leu Ile Asp Asn Asn Leu Cys Asp Asp Asp Phe Cys Pro 
                165                 170                 175     


Thr Arg Ala His Gln Thr His Trp Leu Arg Asn Leu Lys Pro Asn Ile 
            180                 185                 190         


Met Glu Arg Cys Asn Asn Asp Thr Trp Glu Cys His Pro Ile Lys Val 
        195                 200                 205             


Tyr Tyr Gly Trp Val Ala Lys Lys Arg Pro Thr Asn Val Gly His Asp 
    210                 215                 220                 


Leu Asn Tyr Val Gln Thr Gly Leu Ile Ile Glu Ser Gln Tyr Ile Gly 
225                 230                 235                 240 


His Ile Val Met Ser Asp Leu Cys Thr Ile Lys Phe Cys Ser Lys Leu 
                245                 250                 255     


Gly Tyr Leu Phe Pro Asp Gly Ser Trp Trp Glu Leu Lys Phe Pro Leu 
            260                 265                 270         


Asp His Leu Leu Leu Lys Asn His Gln Leu Leu Glu Asn Ser Gly Ser 
        275                 280                 285             


Cys Ser Asp Arg Ser His Gly Asp Thr Leu Thr Lys Asp Gln Arg Gly 
    290                 295                 300                 


Asn Lys Ile Gly Tyr Glu Asp Leu Glu Val Asp Leu Glu Gly Leu Glu 
305                 310                 315                 320 


Leu Arg Gln Lys Ser Arg Asn Leu Asn Leu Ile Cys Leu Asp Lys Val 
                325                 330                 335     


Ala Asn Ile Arg Asn Arg Lys Glu Val Asn Ile Leu Asp Ile Ser Tyr 
            340                 345                 350         


Leu Thr Pro Lys His Pro Gly His Gly Thr Ala Tyr Tyr Leu Tyr Glu 
        355                 360                 365             


Asp Thr Ser Asn Ala Ser Ile Thr His Val Lys Ala Tyr Ser Cys Asn 
    370                 375                 380                 


Tyr Lys Leu Ile Gln Ile His Gly Ala Asp Met Asn Gly Arg Val Asn 
385                 390                 395                 400 


Met Ser Asn Ser Glu Asp Leu Asn Ile Thr Ile Leu Asp Ser Gly Asp 
                405                 410                 415     


Asn Met Thr Ile Ala Asp Leu Gly Ile Ser Lys Cys Lys Asp Leu Ser 
            420                 425                 430         


His Leu Thr Val Asn Gln Thr Arg Asn Ile Ser Cys Glu Lys Asn Val 
        435                 440                 445             


Gly Phe Lys Tyr Pro Glu Gln Val Lys Leu Ser Asn Gly Lys Val Val 
    450                 455                 460                 


Trp Thr Ser Arg Ser Phe Gly Gly Ala Asn Phe His Arg Leu Pro Gly 
465                 470                 475                 480 


Val Arg Phe Gly Val Asn Gly Ile Thr Tyr Asp Leu Lys Gln Gln Met 
                485                 490                 495     


Leu Arg Phe Pro Thr Val Asn Asn Leu Leu Trp Asp Leu Pro Ser Tyr 
            500                 505                 510         


Tyr Ser Thr Asn His Lys Val His Phe Tyr Thr His Pro Thr Lys His 
        515                 520                 525             


Glu Ile Arg Lys Asn Phe Thr Gly Glu Arg Thr Glu Asp Ile Asp Phe 
    530                 535                 540                 


Leu Asp Asp Leu Ile His Arg Lys Leu Asn Arg Thr Asp Phe Pro Thr 
545                 550                 555                 560 


Lys Val Arg Asn Trp Ile Gly Asp Ile Glu Asn Lys Val Val His Phe 
                565                 570                 575     


Phe Ser Asn Val Gly Gly Thr Ile Lys Thr Ala Ile Ser Leu Ile Phe 
            580                 585                 590         


Phe Val Ile Gly Thr Leu Ile Ser Ile Lys Ile Trp Arg Lys Cys Lys 
        595                 600                 605             


Lys Cys Lys Gly Gln Ser Lys Arg Ser Glu Ser Glu Trp Val Ala Lys 
    610                 615                 620                 


Lys Gln Tyr Thr Ala Lys His Glu Met Lys Ser Phe Pro Ser Asn Phe 
625                 630                 635                 640 


Lys Thr Asp Asn Ile Tyr Glu Asp Val Lys Ser Glu Leu Asp Ser Thr 
                645                 650                 655     


Tyr Ser Pro Phe His Val 
            660         


<210>  553
<211>  662
<212>  PRT
<213>  Tibrogargan tibrovirus

<400>  553

Met Glu Ala Ile Thr Ile Glu Ile Ile Ile Ile Ile Leu Thr Ile Ser 
1               5                   10                  15      


Tyr Pro Ile Leu Val Ala Pro Gln Leu Leu Tyr Asn Tyr Pro Phe Asn 
            20                  25                  30          


Cys Lys Lys Gly Pro Lys Met Thr Leu Asp Gly Leu Thr Cys Pro Leu 
        35                  40                  45              


Asp Phe Asn Thr Phe Asn Leu Asp Ser Lys Asp Asn Met Glu Ala Gly 
    50                  55                  60                  


Thr Met Cys Arg Pro Asn Pro Leu Ser Lys Asp Ile Glu Asp Gly Phe 
65                  70                  75                  80  


Leu Cys Tyr Lys Asp Thr Trp Val Thr Thr Cys Glu Glu Thr Trp Tyr 
                85                  90                  95      


Phe Ser Lys Thr Val Lys Asn His Ile Ile His Glu His Ile Thr Lys 
            100                 105                 110         


Asp Glu Cys Phe Glu Ala Leu Ala Thr Tyr Lys Leu Gly Lys His Val 
        115                 120                 125             


Glu Pro Phe Phe Pro Ala Pro Ser Cys Tyr Trp Ser Ala Thr Asn Glu 
    130                 135                 140                 


Glu Arg Ala Thr Phe Val Asn Ile Gln Pro His Gly Val Leu Leu Asp 
145                 150                 155                 160 


Pro Tyr Ser Gly Lys Ile Lys Asp Pro Leu Ile Asp Ser Asp Asn Cys 
                165                 170                 175     


Asp Asn Asp Phe Cys Val Thr Arg Ser His Gln Thr His Trp Leu Arg 
            180                 185                 190         


Asn Arg Lys Pro Asp Ile Met Glu Arg Cys Asn Asn Glu Thr Trp Glu 
        195                 200                 205             


Cys His Pro Ile Lys Ile Tyr Tyr Gly Trp Val Ser Lys Lys Lys Asn 
    210                 215                 220                 


Gln Glu Thr Ser Thr Thr Phe Asn Tyr Val Gln Thr Gly Leu Val Ile 
225                 230                 235                 240 


Glu Ser Gln Tyr Ile Gly His Val Leu Met Ala Asp Leu Cys Ile Met 
                245                 250                 255     


Thr Phe Cys Asn Arg Asp Gly Tyr Leu Phe Pro Asp Gly Ser Trp Trp 
            260                 265                 270         


Glu Ile Lys Tyr Ser Leu Tyr His Ala Phe Thr Lys Asp His Thr Val 
        275                 280                 285             


Leu Asn Asn Ala His Lys Cys Gly Asp Arg Thr His Gly Asp His Leu 
    290                 295                 300                 


Thr Glu Phe Gln Arg Asp Lys Lys Val Gly Tyr Glu Asp Leu Glu Ile 
305                 310                 315                 320 


Asn Leu Glu Gly Leu Glu Met Arg Gln Lys Ser Arg Ser Ile Asn Met 
                325                 330                 335     


Met Cys Leu Asn Arg Leu Ala Glu Ile Arg Asn Thr His His Ile Asn 
            340                 345                 350         


Val Leu Asp Met Ser Tyr Leu Thr Pro Lys His Pro Gly Arg Gly Leu 
        355                 360                 365             


Ala Tyr Tyr Phe Ser Gln Asp Gln Lys Asn Ser Ser Lys Tyr His Val 
    370                 375                 380                 


Lys Val Leu Asp Cys Asp Tyr Lys Leu Ile His Ile His Asp Ala Asp 
385                 390                 395                 400 


Ile Lys Gly Phe Val Asn Ile Thr Lys Tyr Pro Glu Pro Asn Val Thr 
                405                 410                 415     


Ile Leu Gly Leu Lys Asp Asn Leu Thr Phe Ala Asp Leu Gly Ile Ser 
            420                 425                 430         


Arg Cys Gln Asp Leu Thr Pro Leu Asn Gly Ser Arg Asn Ile Ser Cys 
        435                 440                 445             


Glu Glu Ser Ser Gly Pro Leu His Ser Asp Asp Ser Arg Leu Ser Asn 
    450                 455                 460                 


Gly Lys Arg Phe Trp Thr Arg His Ser Phe Gln Gly Ala Asn Phe His 
465                 470                 475                 480 


Glu His Pro Gly Val Arg Ile Gly Val Asn Gly Ile Thr Tyr Asp Ile 
                485                 490                 495     


Arg Lys Gln Ile Leu Arg Phe Pro Ser Thr Ser Asn Leu Leu Trp Asp 
            500                 505                 510         


Leu Pro Ser Tyr Tyr Ser Thr Lys His Arg Val His Phe Phe Gln His 
        515                 520                 525             


Pro Thr Lys His Glu Ile Arg Lys Asn Phe Thr Gly Ser Asp Ser Arg 
    530                 535                 540                 


Asp Ile Asp Val Leu Asp Asp Leu Ile Asn Arg His Ile Asn Arg Thr 
545                 550                 555                 560 


Asp Phe Pro Thr Arg Ile Arg Asn Trp Ile Gly Asn Ile Glu Asp Lys 
                565                 570                 575     


Val Glu His Phe Phe Ser Asn Val Gly Gly Thr Ile Lys Thr Ile Ile 
            580                 585                 590         


Ser Leu Val Leu Phe Val Ile Gly Thr Leu Ile Ser Ile Lys Val Trp 
        595                 600                 605             


Lys Lys Cys Lys Arg His Pro Gln Lys Thr Lys Lys Val Ala Gln Leu 
    610                 615                 620                 


Lys Leu Asn Asp Tyr Glu Lys Thr Tyr Asn Gln Arg Asp Thr Ser Asn 
625                 630                 635                 640 


Asn Asn Asn Asp Asp Leu Tyr Glu Thr Ile Glu Asn Gly Gly Thr Val 
                645                 650                 655     


Tyr Ser Pro Phe His Val 
            660         


<210>  554
<211>  506
<212>  PRT
<213>  Durham tupavirus

<400>  554

Met Trp Ile Ile Leu Leu His Val Ser Phe Val Ala Ser Gln Val Ile 
1               5                   10                  15      


Ile Ala Pro Leu Arg Glu Pro Gln Glu Trp Arg Val Ala Thr Lys Ser 
            20                  25                  30          


Asp Phe Lys Cys Thr Pro Gly Met Leu Asp Asp Ile Glu Gly Pro Ile 
        35                  40                  45              


Asp Phe Trp Arg Val Ser Thr Ile Lys Ala Asp Ala Asn Leu His Ile 
    50                  55                  60                  


Glu Gly Tyr Ala Cys Gln Ala Glu Ile Trp Ile Ser Lys Cys Glu Glu 
65                  70                  75                  80  


Thr Trp Tyr Phe Ser Lys Thr Ile Thr His Ser Val Gln Phe Pro Glu 
                85                  90                  95      


Gly Thr Gln His Ser Cys Gln Asp Glu Leu Arg Lys Gln Lys Ala Glu 
            100                 105                 110         


Gly Ala Pro Val Phe Arg Phe Pro Asp Val Glu Cys Ala Tyr Ala Ser 
        115                 120                 125             


Thr Thr Thr Ala Thr Ser Tyr Phe Leu Arg Leu Thr Pro Met Asn Val 
    130                 135                 140                 


Glu Leu Asn Pro Tyr Ala Ser Thr Leu Leu His Pro Ser Phe Arg Asp 
145                 150                 155                 160 


Gly Lys Cys Thr Asp Leu Glu Val Cys Pro Met Leu His His His Gly 
                165                 170                 175     


Leu Trp Ile Pro Lys Glu Pro Ile Ala Lys Thr Glu Glu Gln Ala Val 
            180                 185                 190         


Phe Glu Lys Val Thr Ile Lys Tyr Lys Leu Ser Tyr Arg His Ser Lys 
        195                 200                 205             


Ala Tyr Gly Tyr Ile Ser Gly Pro Ala Val Pro Phe Ser Asp Leu Arg 
    210                 215                 220                 


Asp Ala Cys Lys Ile Lys Phe Ala Gly Thr Ala Gly Met Arg Leu Gly 
225                 230                 235                 240 


Ser Gly Met Trp Ile Ser Leu Gly Gly Asp His Glu Gln Gly Gly Leu 
                245                 250                 255     


Gly Trp Ser Ser Lys His Thr Thr Asn Ile Phe Asn Asp Leu Gln Ile 
            260                 265                 270         


Asp Asp Cys Ala Pro Gly Thr Lys Val Ser Val Pro His Ala Gly His 
        275                 280                 285             


Ile Gly Asp Leu Leu Glu Ile Lys Met Asn His Met Ala Met Gln Phe 
    290                 295                 300                 


Leu Cys Leu Asp Ala Leu Arg Asn Val Phe Arg Glu Asn Ser Thr Ser 
305                 310                 315                 320 


Arg Leu Asp Leu Ala Lys Leu Ser Pro Ser Asp Ala Gly Glu His Pro 
                325                 330                 335     


Val Tyr Gln Leu Ser Glu Arg Gly Ile Glu Val Gly Ile Thr Met Tyr 
            340                 345                 350         


Gly Leu Ile Asn Trp Ala Pro Asp Ala Arg Glu Asn Arg Leu Gly Tyr 
        355                 360                 365             


His Tyr Gly Thr Ser Lys Ala Glu Gly Lys Asn Pro Ile Thr Trp Lys 
    370                 375                 380                 


Arg Trp Thr Arg Thr Gln Asp Gly Lys Leu Asn Gly Pro Asn Gly Val 
385                 390                 395                 400 


Tyr Gln Ser Asn Asn Thr Ile Val His Pro Asn Leu Ala Leu Leu Gly 
                405                 410                 415     


Asn Leu Ile Met Glu Asp Leu Ala Ala Asp Phe Asp Leu Asp Pro Ile 
            420                 425                 430         


Lys Glu Pro Glu Val Thr His Tyr Asp Ala Asn Trp Glu Thr Glu Ser 
        435                 440                 445             


Ile Gly Arg Gly Glu Asp Thr Arg Tyr Met Thr His Arg Asn Arg Phe 
    450                 455                 460                 


Phe Phe Trp Gly Pro Trp Asn Ser Leu Lys Asn Ile Leu Leu Ala Ser 
465                 470                 475                 480 


Ile Ile Thr Leu Ile Ala Leu Ile Thr Ser Thr Leu Leu Leu Cys Cys 
                485                 490                 495     


Val Cys Lys Lys Arg Gln His Arg Ser Val 
            500                 505     


<210>  555
<211>  533
<212>  PRT
<213>  Klamath tupavirus

<400>  555

Met Phe Arg Thr Leu Phe Phe Ser Leu Leu Gly Leu Cys Thr Gly Leu 
1               5                   10                  15      


Gly Asn Gln Asp Glu Gly His Thr Val Val Leu Pro Val Gln Val Pro 
            20                  25                  30          


Arg Asn Trp Lys Pro Ala Thr Glu Ser Asp Phe Thr Cys Asn His Pro 
        35                  40                  45              


Pro Gln Trp Glu Pro Asp Thr Pro Phe Val Leu Leu Asn Ala Lys Met 
    50                  55                  60                  


Leu Ala Lys Gln Glu Pro Ile Gln Val Arg Gly Trp Phe Cys Tyr Lys 
65                  70                  75                  80  


Ser Lys Trp Thr Thr Gly Cys Gly Thr Asn Leu Leu Phe Ser Lys Ser 
                85                  90                  95      


Val Thr His Lys Val Thr His Leu Pro Val Ser Glu His Glu Cys Arg 
            100                 105                 110         


Glu Ala Val Asp Arg Glu Arg Gln Gly Arg Ser Glu Pro Glu Thr Phe 
        115                 120                 125             


Pro Asp Pro Val Cys Ala Trp Met Ser Asp Thr Thr Lys Asp Thr Val 
    130                 135                 140                 


Tyr Thr His Val Leu Pro His Ala Ala Gln Tyr Asp Pro Arg Ser Asn 
145                 150                 155                 160 


Arg Leu Thr Ser Pro Gly Phe Pro Gln Gly Val Cys Asp Asn Leu Arg 
                165                 170                 175     


Trp Cys Ser Ala Thr Thr Pro Asp Arg Trp Trp Leu Pro Asp Ser Asp 
            180                 185                 190         


Leu Glu Val Gln Lys Gln Leu Glu Thr His Met Asp Ser Val Ile Leu 
        195                 200                 205             


Lys Leu Phe Pro Met Pro Phe Pro Ala Glu Asn Pro Tyr Val Gly Pro 
    210                 215                 220                 


His Ser Val Val Ser Gly Ser Arg Ile Pro Pro Thr Val Val Glu Gly 
225                 230                 235                 240 


Ser Cys Lys Leu Thr Leu Leu Gly Asp Glu Gly Ile Val Leu Pro Thr 
                245                 250                 255     


Gly Ile Trp Leu Gly Ile Lys Tyr Gly Asp Tyr Gln Leu Leu His Gly 
            260                 265                 270         


Gly Arg Lys Met Gly Lys Lys Leu Gln Val Gln Gln Ala Asn Leu Gly 
        275                 280                 285             


Phe Ile Thr Lys Gln Cys Lys Ala Glu Asp His Arg Val Ile Pro Thr 
    290                 295                 300                 


Thr Glu Ser Pro Phe Tyr Arg Val Gln Leu Ser Thr Leu His Tyr Met 
305                 310                 315                 320 


Gln Tyr Gln Phe Cys Leu Glu Ser Leu Asp Lys Leu Asn Asn Asn Gln 
                325                 330                 335     


Thr Leu Ser Arg Val Asp Leu Ser Arg Phe Ala Pro Arg Leu Pro Gly 
            340                 345                 350         


Leu Gly Lys Val Phe Gln Leu Arg Asp Ser Ala Val Trp Val Gly Met 
        355                 360                 365             


Thr Met Tyr Glu Met Ala Val Ile Pro Thr Gly Asp Glu Thr Ser Lys 
    370                 375                 380                 


Asp Ile Ile Gly Tyr Ile Gln Asp Ser Thr Glu Ala Tyr Thr Val Ala 
385                 390                 395                 400 


Ile His Trp Thr Asp Trp Ser Met Gly Ser Asn Arg Val Glu Asn Gly 
                405                 410                 415     


Pro Asn Gly Ile Phe Arg Lys Thr Gly Lys Val Tyr His Pro Gln Gly 
            420                 425                 430         


Leu Tyr Gln Asp Leu Ser Leu Asp Leu Glu Leu Leu Leu Thr His Ser 
        435                 440                 445             


Val Asp Ile Val Arg His Pro Val Leu Glu His Val Lys Glu Ile Pro 
    450                 455                 460                 


Gln Ile Asp Arg Val Val Lys Asp Gln Ser Gln Thr Thr Ile His Leu 
465                 470                 475                 480 


Asn Ser Gly Ile Ser His Phe Trp Glu Asn Phe His Trp Leu Gly Gly 
                485                 490                 495     


Val Lys Asp Lys Val Ile Leu Gly Ile Val Gly Val Val Ser Phe Val 
            500                 505                 510         


Gly Thr Leu Ile Gly Gly Met Trp Val Cys Lys Ser Arg Lys Arg Asp 
        515                 520                 525             


Gln Lys Arg Gly Tyr 
    530             


<210>  556
<211>  531
<212>  PRT
<213>  Tupaia tupavirus

<400>  556

Met Ala Pro Gln Thr Ile Ser Leu Leu Trp Ala Met Val Cys Val Ser 
1               5                   10                  15      


Val Tyr Thr Arg Ala Asn Arg Val Val Ala Pro Ile His Glu Pro Gln 
            20                  25                  30          


Asn Trp Lys Pro Ala Thr Val Asp Asp Phe Thr Cys Arg Thr Gly Phe 
        35                  40                  45              


Asn Leu Asp Phe Asp Ser Lys Phe Ile Lys Thr Lys Ala Leu Val Leu 
    50                  55                  60                  


Lys Arg Val Gly Gln Ala Lys Val Lys Gly Tyr Leu Cys Met Lys Asn 
65                  70                  75                  80  


Arg Trp Thr Thr Thr Cys Glu Thr Asn Trp Leu Tyr Ser Lys Ser Val 
                85                  90                  95      


Ser His His Ile Thr His Val Ala Val Ser Ala Glu Glu Cys Tyr Asn 
            100                 105                 110         


Lys Ile Arg Asp Asp Ala Ser Gly Asn Leu Lys Ile Glu Ser Tyr Pro 
        115                 120                 125             


Asn Pro Gln Cys Ala Trp Ser Ser Thr Val Ser Arg Glu Glu Asp Phe 
    130                 135                 140                 


Ile His Ile Ser Thr Ser Asp Val Gly Tyr Asp Met Tyr Thr Asp Thr 
145                 150                 155                 160 


Val Leu Ser Pro Ser Phe Pro Gly Gly Thr Cys Lys Leu Lys Thr Cys 
                165                 170                 175     


Cys Lys Thr Ile Tyr Pro Asn Ile Val Trp Val Pro Glu Thr Pro Ala 
            180                 185                 190         


Gln Thr Gln Val Arg Asp Ala Leu Phe Asp Glu Thr Met Val Thr Val 
        195                 200                 205             


Thr Val Glu Ala Lys Lys Val Val Lys Asp Ser Trp Val Thr Gly Ala 
    210                 215                 220                 


Thr Ile Thr Pro Ser Val Met Glu Gly Ser Cys Lys Lys Thr Leu Gly 
225                 230                 235                 240 


Ser Lys Ser Gly Ile Leu Leu Pro Asn Gly Gln Trp Phe Ser Ile Val 
                245                 250                 255     


Glu Thr Gly Gln Ile Thr Ile Gln Pro Lys Gly Ser Val Glu Glu Lys 
            260                 265                 270         


Glu Thr Trp Val Asn Leu Ile Asn Asp Leu Asn Leu Ser Asp Cys Ala 
        275                 280                 285             


Glu Thr Gln Glu Ala Lys Val Pro Thr Ala Glu Phe Thr Val Tyr Lys 
    290                 295                 300                 


Thr Glu Ser Met Val Phe Asn Ile Leu Asn Tyr His Leu Cys Leu Glu 
305                 310                 315                 320 


Thr Val Ala Lys Ala Arg Ser Gly Lys Asn Leu Thr Arg Leu Asp Leu 
                325                 330                 335     


Ala Arg Leu Ala Pro Glu Ile Pro Gly Val Ala His Val Tyr Gln Leu 
            340                 345                 350         


Thr Ser Asp Gly Val Arg Val Gly Ser Thr Arg Tyr Glu Ile Ile Ala 
        355                 360                 365             


Trp Lys Pro Thr Met Gly Leu Asp Lys Thr Leu Gly Leu Thr Ile Val 
    370                 375                 380                 


Pro Ser Gly Asn Arg Asn Ser Glu Thr Ile Lys Trp Ile Glu Trp Thr 
385                 390                 395                 400 


Arg Thr Asp Asp Gly Leu Leu Asn Gly Pro Asn Gly Ile Phe Ile Ala 
                405                 410                 415     


Asp Gly Lys Glu Ile Val His Pro Asn Leu Lys Met Val Ser Phe Glu 
            420                 425                 430         


Leu Glu Thr Tyr Leu Ile Ser Glu His Ser Thr Gln Leu Val Pro His 
        435                 440                 445             


Pro Val Ile His Ser Ile Ser Asp Glu Ile Tyr Pro Glu Asn Tyr Thr 
    450                 455                 460                 


Ile Gly Gly Lys Asn Ser Tyr Ile Lys Ile His Thr Pro Thr Ala Tyr 
465                 470                 475                 480 


Phe Trp Ser Gly Ile His Trp Ile Glu Gly Ala Val Gln Lys Leu Phe 
                485                 490                 495     


Ile Val Val Val Ala Thr Ala Leu Ile Gly Leu Phe Ile Leu Val Val 
            500                 505                 510         


Trp Leu Cys Cys Gly Cys Cys Ser Lys Ser Arg Pro Val Arg Asn Gln 
        515                 520                 525             


Lys Trp Glu 
    530     


<210>  557
<211>  511
<212>  PRT
<213>  Alagoas vesiculovirus

<400>  557

Met Thr Pro Ala Phe Ile Leu Cys Met Leu Leu Ala Gly Ser Ser Trp 
1               5                   10                  15      


Ala Lys Phe Thr Ile Val Phe Pro Gln Ser Gln Lys Gly Asp Trp Lys 
            20                  25                  30          


Asp Val Pro Pro Asn Tyr Arg Tyr Cys Pro Ser Ser Ala Asp Gln Asn 
        35                  40                  45              


Trp His Gly Asp Leu Leu Gly Val Asn Ile Arg Ala Lys Met Pro Lys 
    50                  55                  60                  


Val His Lys Ala Ile Lys Ala Asp Gly Trp Met Cys His Ala Ala Lys 
65                  70                  75                  80  


Trp Val Thr Thr Cys Asp Tyr Arg Trp Tyr Gly Pro Gln Tyr Ile Thr 
                85                  90                  95      


His Ser Ile His Ser Phe Ile Pro Thr Lys Ala Gln Cys Glu Glu Ser 
            100                 105                 110         


Ile Lys Gln Thr Lys Glu Gly Val Trp Ile Asn Pro Gly Phe Pro Pro 
        115                 120                 125             


Lys Asn Cys Gly Tyr Ala Ser Val Ser Asp Ala Glu Ser Ile Ile Val 
    130                 135                 140                 


Gln Ala Thr Ala His Ser Val Met Ile Asp Glu Tyr Ser Gly Asp Trp 
145                 150                 155                 160 


Leu Asp Ser Gln Phe Pro Thr Gly Arg Cys Thr Gly Ser Thr Cys Glu 
                165                 170                 175     


Thr Ile His Asn Ser Thr Leu Trp Tyr Ala Asp Tyr Gln Val Thr Gly 
            180                 185                 190         


Leu Cys Asp Ser Ala Leu Val Ser Thr Glu Val Thr Phe Tyr Ser Glu 
        195                 200                 205             


Asp Gly Leu Met Thr Ser Ile Gly Arg Gln Asn Thr Gly Tyr Arg Ser 
    210                 215                 220                 


Asn Tyr Phe Pro Tyr Glu Lys Gly Ala Ala Ala Cys Arg Met Lys Tyr 
225                 230                 235                 240 


Cys Thr His Glu Gly Ile Arg Leu Pro Ser Gly Val Trp Phe Glu Met 
                245                 250                 255     


Val Asp Lys Glu Leu Leu Glu Ser Val Gln Met Pro Glu Cys Pro Ala 
            260                 265                 270         


Gly Leu Thr Ile Ser Ala Pro Thr Gln Thr Ser Val Asp Val Ser Leu 
        275                 280                 285             


Ile Leu Asp Val Glu Arg Met Leu Asp Tyr Ser Leu Cys Gln Glu Thr 
    290                 295                 300                 


Trp Ser Lys Val His Ser Gly Leu Pro Ile Ser Pro Val Asp Leu Gly 
305                 310                 315                 320 


Tyr Ile Ala Pro Lys Asn Pro Gly Ala Gly Pro Ala Phe Thr Ile Val 
                325                 330                 335     


Asn Gly Thr Leu Lys Tyr Phe Asp Thr Arg Tyr Leu Arg Ile Asp Ile 
            340                 345                 350         


Glu Gly Pro Val Leu Lys Lys Met Thr Gly Lys Val Ser Gly Thr Pro 
        355                 360                 365             


Thr Lys Arg Glu Leu Trp Thr Glu Trp Phe Pro Tyr Asp Asp Val Glu 
    370                 375                 380                 


Ile Gly Pro Asn Gly Val Leu Lys Thr Pro Glu Gly Tyr Lys Phe Pro 
385                 390                 395                 400 


Leu Tyr Met Ile Gly His Gly Leu Leu Asp Ser Asp Leu Gln Lys Thr 
                405                 410                 415     


Ser Gln Ala Glu Val Phe His His Pro Gln Ile Ala Glu Ala Val Gln 
            420                 425                 430         


Lys Leu Pro Asp Asp Glu Thr Leu Phe Phe Gly Asp Thr Gly Ile Ser 
        435                 440                 445             


Lys Asn Pro Val Glu Val Ile Glu Gly Trp Phe Ser Asn Trp Arg Ser 
    450                 455                 460                 


Ser Val Met Ala Ile Val Phe Ala Ile Leu Leu Leu Val Ile Thr Val 
465                 470                 475                 480 


Leu Met Val Arg Leu Cys Val Ala Phe Arg His Phe Cys Cys Gln Lys 
                485                 490                 495     


Arg His Lys Ile Tyr Asn Asp Leu Glu Met Asn Gln Leu Arg Arg 
            500                 505                 510     


<210>  558
<211>  523
<212>  PRT
<213>  Carajas vesiculovirus

<400>  558

Met Lys Met Lys Met Val Ile Ala Gly Leu Ile Leu Cys Ile Gly Ile 
1               5                   10                  15      


Leu Pro Ala Ile Gly Lys Ile Thr Ile Ser Phe Pro Gln Ser Leu Lys 
            20                  25                  30          


Gly Asp Trp Arg Pro Val Pro Lys Gly Tyr Asn Tyr Cys Pro Thr Ser 
        35                  40                  45              


Ala Asp Lys Asn Leu His Gly Asp Leu Ile Asp Ile Gly Leu Arg Leu 
    50                  55                  60                  


Arg Ala Pro Lys Ser Phe Lys Gly Ile Ser Ala Asp Gly Trp Met Cys 
65                  70                  75                  80  


His Ala Ala Arg Trp Ile Thr Thr Cys Asp Phe Arg Trp Tyr Gly Pro 
                85                  90                  95      


Lys Tyr Ile Thr His Ser Ile His Ser Phe Arg Pro Ser Asn Asp Gln 
            100                 105                 110         


Cys Lys Glu Ala Ile Arg Leu Thr Asn Glu Gly Asn Trp Ile Asn Pro 
        115                 120                 125             


Gly Phe Pro Pro Gln Ser Cys Gly Tyr Ala Ser Val Thr Asp Ser Glu 
    130                 135                 140                 


Ser Val Val Val Thr Val Thr Lys His Gln Val Leu Val Asp Glu Tyr 
145                 150                 155                 160 


Ser Gly Ser Trp Ile Asp Ser Gln Phe Pro Gly Gly Ser Cys Thr Ser 
                165                 170                 175     


Pro Ile Cys Asp Thr Val His Asn Ser Thr Leu Trp His Ala Asp His 
            180                 185                 190         


Thr Leu Asp Ser Ile Cys Asp Gln Glu Phe Val Ala Met Asp Ala Val 
        195                 200                 205             


Leu Phe Thr Glu Ser Gly Lys Phe Glu Glu Phe Gly Lys Pro Asn Ser 
    210                 215                 220                 


Gly Ile Arg Ser Asn Tyr Phe Pro Tyr Glu Ser Leu Lys Asp Val Cys 
225                 230                 235                 240 


Gln Met Asp Phe Cys Lys Arg Lys Gly Phe Lys Leu Pro Ser Gly Val 
                245                 250                 255     


Trp Phe Glu Ile Glu Asp Ala Glu Lys Ser His Lys Ala Gln Val Glu 
            260                 265                 270         


Leu Lys Ile Lys Arg Cys Pro His Gly Ala Val Ile Ser Ala Pro Asn 
        275                 280                 285             


Gln Asn Ala Ala Asp Ile Asn Leu Ile Met Asp Val Glu Arg Ile Leu 
    290                 295                 300                 


Asp Tyr Ser Leu Cys Gln Ala Thr Trp Ser Lys Ile Gln Asn Lys Glu 
305                 310                 315                 320 


Ala Leu Thr Pro Ile Asp Ile Ser Tyr Leu Gly Pro Lys Asn Pro Gly 
                325                 330                 335     


Pro Gly Pro Ala Phe Thr Ile Ile Asn Gly Thr Leu His Tyr Phe Asn 
            340                 345                 350         


Thr Arg Tyr Ile Arg Val Asp Ile Ala Gly Pro Val Thr Lys Glu Ile 
        355                 360                 365             


Thr Gly Phe Val Ser Gly Thr Ser Thr Ser Arg Val Leu Trp Asp Gln 
    370                 375                 380                 


Trp Phe Pro Tyr Gly Glu Asn Ser Ile Gly Pro Asn Gly Leu Leu Lys 
385                 390                 395                 400 


Thr Ala Ser Gly Tyr Lys Tyr Pro Leu Phe Met Val Gly Thr Gly Val 
                405                 410                 415     


Leu Asp Ala Asp Ile His Lys Leu Gly Glu Ala Thr Val Ile Glu His 
            420                 425                 430         


Pro His Ala Lys Glu Ala Gln Lys Val Val Asp Asp Ser Glu Val Ile 
        435                 440                 445             


Phe Phe Gly Asp Thr Gly Val Ser Lys Asn Pro Val Glu Val Val Glu 
    450                 455                 460                 


Gly Trp Phe Ser Gly Trp Arg Ser Ser Leu Met Ser Ile Phe Gly Ile 
465                 470                 475                 480 


Ile Leu Leu Ile Val Cys Leu Val Leu Ile Val Arg Ile Leu Ile Ala 
                485                 490                 495     


Leu Lys Tyr Cys Cys Val Arg His Lys Lys Arg Thr Ile Tyr Lys Glu 
            500                 505                 510         


Asp Leu Glu Met Gly Arg Ile Pro Arg Arg Ala 
        515                 520             


<210>  559
<211>  530
<212>  PRT
<213>  Chandipura vesiculovirus

<400>  559

Met Thr Ser Ser Val Thr Ile Ser Val Val Leu Leu Ile Ser Phe Ile 
1               5                   10                  15      


Thr Pro Leu Tyr Ser Tyr Leu Ser Ile Ala Phe Pro Glu Asn Thr Lys 
            20                  25                  30          


Leu Asp Trp Lys Pro Val Thr Lys Asn Thr Arg Tyr Cys Pro Met Gly 
        35                  40                  45              


Gly Glu Trp Phe Leu Glu Pro Gly Leu Gln Glu Glu Ser Phe Leu Ser 
    50                  55                  60                  


Ser Thr Pro Ile Gly Ala Thr Pro Ser Lys Ser Asp Gly Phe Leu Cys 
65                  70                  75                  80  


His Ala Ala Lys Trp Val Thr Thr Cys Asp Phe Arg Trp Tyr Gly Pro 
                85                  90                  95      


Lys Tyr Ile Thr His Ser Ile His Asn Ile Lys Pro Thr Arg Ser Asp 
            100                 105                 110         


Cys Asp Thr Ala Leu Ala Ser Tyr Lys Ser Gly Thr Leu Val Ser Leu 
        115                 120                 125             


Gly Phe Pro Pro Glu Ser Cys Gly Tyr Ala Ser Val Thr Asp Ser Glu 
    130                 135                 140                 


Phe Leu Val Ile Met Ile Thr Pro His His Val Gly Val Asp Asp Tyr 
145                 150                 155                 160 


Arg Gly His Trp Val Asp Pro Leu Phe Val Gly Gly Glu Cys Asp Gln 
                165                 170                 175     


Ser Tyr Cys Asp Thr Ile His Asn Ser Ser Val Trp Ile Pro Ala Asp 
            180                 185                 190         


Gln Thr Lys Lys Asn Ile Cys Gly Gln Ser Phe Thr Pro Leu Thr Val 
        195                 200                 205             


Thr Val Ala Tyr Asp Lys Thr Lys Glu Ile Ala Ala Gly Gly Ile Val 
    210                 215                 220                 


Phe Lys Ser Lys Tyr His Ser His Met Glu Gly Ala Arg Thr Cys Arg 
225                 230                 235                 240 


Leu Ser Tyr Cys Gly Arg Asn Gly Ile Lys Phe Pro Asn Gly Glu Trp 
                245                 250                 255     


Val Ser Leu Asp Val Lys Thr Arg Ile Gln Glu Lys His Leu Leu Pro 
            260                 265                 270         


Leu Phe Lys Glu Cys Pro Ala Gly Thr Glu Val Arg Ser Thr Leu Gln 
        275                 280                 285             


Ser Asp Gly Ala Gln Val Leu Thr Ser Glu Ile Gln Arg Ile Leu Asp 
    290                 295                 300                 


Tyr Ser Leu Cys Gln Asn Thr Trp Asp Lys Val Glu Arg Lys Glu Pro 
305                 310                 315                 320 


Leu Ser Pro Leu Asp Leu Ser Tyr Leu Ala Ser Lys Ser Pro Gly Lys 
                325                 330                 335     


Gly Leu Ala Tyr Thr Val Ile Asn Gly Thr Leu Ser Phe Ala His Thr 
            340                 345                 350         


Arg Tyr Val Arg Met Trp Ile Asp Gly Pro Val Leu Lys Glu Pro Lys 
        355                 360                 365             


Gly Lys Arg Glu Ser Pro Ser Gly Ile Ser Ser Asp Ile Trp Thr Gln 
    370                 375                 380                 


Trp Phe Lys Tyr Gly Asp Met Glu Ile Gly Pro Asn Gly Leu Leu Lys 
385                 390                 395                 400 


Thr Ala Gly Gly Tyr Lys Phe Pro Trp His Leu Ile Gly Met Gly Ile 
                405                 410                 415     


Val Asp Asn Glu Leu His Glu Leu Ser Glu Ala Asn Pro Leu Asp His 
            420                 425                 430         


Pro Gln Leu Pro His Ala Gln Ser Ile Ala Asp Asp Ser Glu Glu Ile 
        435                 440                 445             


Phe Phe Gly Asp Thr Gly Val Ser Lys Asn Pro Val Glu Leu Val Thr 
    450                 455                 460                 


Gly Trp Phe Thr Ser Trp Lys Glu Ser Leu Ala Ala Gly Val Val Leu 
465                 470                 475                 480 


Ile Leu Val Val Val Leu Ile Tyr Gly Val Leu Arg Cys Phe Pro Val 
                485                 490                 495     


Leu Cys Thr Thr Cys Arg Lys Pro Lys Trp Lys Lys Gly Val Glu Arg 
            500                 505                 510         


Ser Asp Ser Phe Glu Met Arg Ile Phe Lys Pro Asn Asn Met Arg Ala 
        515                 520                 525             


Arg Val 
    530 


<210>  560
<211>  512
<212>  PRT
<213>  Cocal vesiculovirus

<400>  560

Met Asn Phe Leu Leu Leu Thr Phe Ile Val Leu Pro Leu Cys Ser His 
1               5                   10                  15      


Ala Lys Phe Ser Ile Val Phe Pro Gln Ser Gln Lys Gly Asn Trp Lys 
            20                  25                  30          


Asn Val Pro Ser Ser Tyr His Tyr Cys Pro Ser Ser Ser Asp Gln Asn 
        35                  40                  45              


Trp His Asn Asp Leu Leu Gly Ile Thr Met Lys Val Lys Met Pro Lys 
    50                  55                  60                  


Thr His Lys Ala Ile Gln Ala Asp Gly Trp Met Cys His Ala Ala Lys 
65                  70                  75                  80  


Trp Ile Thr Thr Cys Asp Phe Arg Trp Tyr Gly Pro Lys Tyr Ile Thr 
                85                  90                  95      


His Ser Ile His Ser Ile Gln Pro Thr Ser Glu Gln Cys Lys Glu Ser 
            100                 105                 110         


Ile Lys Gln Thr Lys Gln Gly Thr Trp Met Ser Pro Gly Phe Pro Pro 
        115                 120                 125             


Gln Asn Cys Gly Tyr Ala Thr Val Thr Asp Ser Val Ala Val Val Val 
    130                 135                 140                 


Gln Ala Thr Pro His His Val Leu Val Asp Glu Tyr Thr Gly Glu Trp 
145                 150                 155                 160 


Ile Asp Ser Gln Phe Pro Asn Gly Lys Cys Glu Thr Glu Glu Cys Glu 
                165                 170                 175     


Thr Val His Asn Ser Thr Val Trp Tyr Ser Asp Tyr Lys Val Thr Gly 
            180                 185                 190         


Leu Cys Asp Ala Thr Leu Val Asp Thr Glu Ile Thr Phe Phe Ser Glu 
        195                 200                 205             


Asp Gly Lys Lys Glu Ser Ile Gly Lys Pro Asn Thr Gly Tyr Arg Ser 
    210                 215                 220                 


Asn Tyr Phe Ala Tyr Glu Lys Gly Asp Lys Val Cys Lys Met Asn Tyr 
225                 230                 235                 240 


Cys Lys His Ala Gly Val Arg Leu Pro Ser Gly Val Trp Phe Glu Phe 
                245                 250                 255     


Val Asp Gln Asp Val Tyr Ala Ala Ala Lys Leu Pro Glu Cys Pro Val 
            260                 265                 270         


Gly Ala Thr Ile Ser Ala Pro Thr Gln Thr Ser Val Asp Val Ser Leu 
        275                 280                 285             


Ile Leu Asp Val Glu Arg Ile Leu Asp Tyr Ser Leu Cys Gln Glu Thr 
    290                 295                 300                 


Trp Ser Lys Ile Arg Ser Lys Gln Pro Val Ser Pro Val Asp Leu Ser 
305                 310                 315                 320 


Tyr Leu Ala Pro Lys Asn Pro Gly Thr Gly Pro Ala Phe Thr Ile Ile 
                325                 330                 335     


Asn Gly Thr Leu Lys Tyr Phe Glu Thr Arg Tyr Ile Arg Ile Asp Ile 
            340                 345                 350         


Asp Asn Pro Ile Ile Ser Lys Met Val Gly Lys Ile Ser Gly Ser Gln 
        355                 360                 365             


Thr Glu Arg Glu Leu Trp Thr Glu Trp Phe Pro Tyr Glu Gly Val Glu 
    370                 375                 380                 


Ile Gly Pro Asn Gly Ile Leu Lys Thr Pro Thr Gly Tyr Lys Phe Pro 
385                 390                 395                 400 


Leu Phe Met Ile Gly His Gly Met Leu Asp Ser Asp Leu His Lys Thr 
                405                 410                 415     


Ser Gln Ala Glu Val Phe Glu His Pro His Leu Ala Glu Ala Pro Lys 
            420                 425                 430         


Gln Leu Pro Glu Glu Glu Thr Leu Phe Phe Gly Asp Thr Gly Ile Ser 
        435                 440                 445             


Lys Asn Pro Val Glu Leu Ile Glu Gly Trp Phe Ser Ser Trp Lys Ser 
    450                 455                 460                 


Thr Val Val Thr Phe Phe Phe Ala Ile Gly Val Phe Ile Leu Leu Tyr 
465                 470                 475                 480 


Val Val Ala Arg Ile Val Ile Ala Val Arg Tyr Arg Tyr Gln Gly Ser 
                485                 490                 495     


Asn Asn Lys Arg Ile Tyr Asn Asp Ile Glu Met Ser Arg Phe Arg Lys 
            500                 505                 510         


<210>  561
<211>  511
<212>  PRT
<213>  Indiana vesiculovirus

<400>  561

Met Lys Cys Leu Leu Tyr Leu Ala Phe Leu Phe Ile Gly Val Asn Cys 
1               5                   10                  15      


Lys Phe Thr Ile Val Phe Pro His Asn Gln Lys Gly Asn Trp Lys Asn 
            20                  25                  30          


Val Pro Ser Asn Tyr His Tyr Cys Pro Ser Ser Ser Asp Leu Asn Trp 
        35                  40                  45              


His Asn Asp Leu Ile Gly Thr Ala Ile Gln Val Lys Met Pro Lys Ser 
    50                  55                  60                  


His Lys Ala Ile Gln Ala Asp Gly Trp Met Cys His Ala Ser Lys Trp 
65                  70                  75                  80  


Val Thr Thr Cys Asp Phe Arg Trp Tyr Gly Pro Lys Tyr Ile Thr Gln 
                85                  90                  95      


Ser Ile Arg Ser Phe Thr Pro Ser Val Glu Gln Cys Lys Glu Ser Ile 
            100                 105                 110         


Glu Gln Thr Lys Gln Gly Thr Trp Leu Asn Pro Gly Phe Pro Pro Gln 
        115                 120                 125             


Ser Cys Gly Tyr Ala Thr Val Thr Asp Ala Glu Ala Val Ile Val Gln 
    130                 135                 140                 


Val Thr Pro His His Val Leu Val Asp Glu Tyr Thr Gly Glu Trp Val 
145                 150                 155                 160 


Asp Ser Gln Phe Ile Asn Gly Lys Cys Ser Asn Tyr Ile Cys Pro Thr 
                165                 170                 175     


Val His Asn Ser Thr Thr Trp His Ser Asp Tyr Lys Val Lys Gly Leu 
            180                 185                 190         


Cys Asp Ser Asn Leu Ile Ser Met Asp Ile Thr Phe Phe Ser Glu Asp 
        195                 200                 205             


Gly Glu Leu Ser Ser Leu Gly Lys Glu Gly Thr Gly Phe Arg Ser Asn 
    210                 215                 220                 


Tyr Phe Ala Tyr Glu Thr Gly Gly Lys Ala Cys Lys Met Gln Tyr Cys 
225                 230                 235                 240 


Lys His Trp Gly Val Arg Leu Pro Ser Gly Val Trp Phe Glu Met Ala 
                245                 250                 255     


Asp Lys Asp Leu Phe Ala Ala Ala Arg Phe Pro Glu Cys Pro Glu Gly 
            260                 265                 270         


Ser Ser Ile Ser Ala Pro Ser Gln Thr Ser Val Asp Val Ser Leu Ile 
        275                 280                 285             


Gln Asp Val Glu Arg Ile Leu Asp Tyr Ser Leu Cys Gln Glu Thr Trp 
    290                 295                 300                 


Ser Lys Ile Arg Ala Gly Leu Pro Ile Ser Pro Val Asp Leu Ser Tyr 
305                 310                 315                 320 


Leu Ala Pro Lys Asn Pro Gly Thr Gly Pro Ala Phe Thr Ile Ile Asn 
                325                 330                 335     


Gly Thr Leu Lys Tyr Phe Glu Thr Arg Tyr Ile Arg Val Asp Ile Ala 
            340                 345                 350         


Ala Pro Ile Leu Ser Arg Met Val Gly Met Ile Ser Gly Thr Thr Thr 
        355                 360                 365             


Glu Arg Glu Leu Trp Asp Asp Trp Ala Pro Tyr Glu Asp Val Glu Ile 
    370                 375                 380                 


Gly Pro Asn Gly Val Leu Arg Thr Ser Ser Gly Tyr Lys Phe Pro Leu 
385                 390                 395                 400 


Tyr Met Ile Gly His Gly Met Leu Asp Ser Asp Leu His Leu Ser Ser 
                405                 410                 415     


Lys Ala Gln Val Phe Glu His Pro His Ile Gln Asp Ala Ala Ser Gln 
            420                 425                 430         


Leu Pro Asp Asp Glu Ser Leu Phe Phe Gly Asp Thr Gly Leu Ser Lys 
        435                 440                 445             


Asn Pro Ile Glu Leu Val Glu Gly Trp Phe Ser Ser Trp Lys Ser Ser 
    450                 455                 460                 


Ile Ala Ser Phe Phe Phe Ile Ile Gly Leu Ile Ile Gly Leu Phe Leu 
465                 470                 475                 480 


Val Leu Arg Val Gly Ile His Leu Cys Ile Lys Leu Lys His Thr Lys 
                485                 490                 495     


Lys Arg Gln Ile Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Lys 
            500                 505                 510     


<210>  562
<211>  523
<212>  PRT
<213>  Isfahan vesiculovirus

<400>  562

Met Thr Ser Val Leu Phe Met Val Gly Val Leu Leu Gly Ala Phe Gly 
1               5                   10                  15      


Ser Thr His Cys Ser Ile Gln Ile Val Phe Pro Ser Glu Thr Lys Leu 
            20                  25                  30          


Val Trp Lys Pro Val Leu Lys Gly Thr Arg Tyr Cys Pro Gln Ser Ala 
        35                  40                  45              


Glu Leu Asn Leu Glu Pro Asp Leu Lys Thr Met Ala Phe Asp Ser Lys 
    50                  55                  60                  


Val Pro Ile Gly Ile Thr Pro Ser Asn Ser Asp Gly Tyr Leu Cys His 
65                  70                  75                  80  


Ala Ala Lys Trp Val Thr Thr Cys Asp Phe Arg Trp Tyr Gly Pro Lys 
                85                  90                  95      


Tyr Ile Thr His Ser Val His Ser Leu Arg Pro Thr Val Ser Asp Cys 
            100                 105                 110         


Lys Ala Ala Val Glu Ala Tyr Asn Ala Gly Thr Leu Met Tyr Pro Gly 
        115                 120                 125             


Phe Pro Pro Glu Ser Cys Gly Tyr Ala Ser Ile Thr Asp Ser Glu Phe 
    130                 135                 140                 


Tyr Val Met Leu Val Thr Pro His Pro Val Gly Val Asp Asp Tyr Arg 
145                 150                 155                 160 


Gly His Trp Val Asp Pro Leu Phe Pro Thr Ser Glu Cys Asn Ser Asn 
                165                 170                 175     


Phe Cys Glu Thr Val His Asn Ala Thr Met Trp Ile Pro Lys Asp Leu 
            180                 185                 190         


Lys Thr His Asp Val Cys Ser Gln Asp Phe Gln Thr Ile Arg Val Ser 
        195                 200                 205             


Val Met Tyr Pro Gln Thr Lys Pro Thr Lys Gly Ala Asp Leu Thr Leu 
    210                 215                 220                 


Lys Ser Lys Phe His Ala His Met Lys Gly Asp Arg Val Cys Lys Met 
225                 230                 235                 240 


Lys Phe Cys Asn Lys Asn Gly Leu Arg Leu Gly Asn Gly Glu Trp Ile 
                245                 250                 255     


Glu Val Gly Asp Glu Val Met Leu Asp Asn Ser Lys Leu Leu Ser Leu 
            260                 265                 270         


Phe Pro Asp Cys Leu Val Gly Ser Val Val Lys Ser Thr Leu Leu Ser 
        275                 280                 285             


Glu Gly Val Gln Thr Ala Leu Trp Glu Thr Asp Arg Leu Leu Asp Tyr 
    290                 295                 300                 


Ser Leu Cys Gln Asn Thr Trp Glu Lys Ile Asp Arg Lys Glu Pro Leu 
305                 310                 315                 320 


Ser Ala Val Asp Leu Ser Tyr Leu Ala Pro Arg Ser Pro Gly Lys Gly 
                325                 330                 335     


Met Ala Tyr Ile Val Ala Asn Gly Ser Leu Met Ser Ala Pro Ala Arg 
            340                 345                 350         


Tyr Ile Arg Val Trp Ile Asp Ser Pro Ile Leu Lys Glu Ile Lys Gly 
        355                 360                 365             


Lys Lys Glu Ser Ala Ser Gly Ile Asp Thr Val Leu Trp Glu Gln Trp 
    370                 375                 380                 


Leu Pro Phe Asn Gly Met Glu Leu Gly Pro Asn Gly Leu Ile Lys Thr 
385                 390                 395                 400 


Lys Ser Gly Tyr Lys Phe Pro Leu Tyr Leu Leu Gly Met Gly Ile Val 
                405                 410                 415     


Asp Gln Asp Leu Gln Glu Leu Ser Ser Val Asn Pro Val Asp His Pro 
            420                 425                 430         


His Val Pro Ile Ala Gln Ala Phe Val Ser Glu Gly Glu Glu Val Phe 
        435                 440                 445             


Phe Gly Asp Thr Gly Val Ser Lys Asn Pro Ile Glu Leu Ile Ser Gly 
    450                 455                 460                 


Trp Phe Ser Asp Trp Lys Glu Thr Ala Ala Ala Leu Gly Phe Ala Ala 
465                 470                 475                 480 


Ile Ser Val Ile Leu Ile Ile Gly Leu Met Arg Leu Leu Pro Leu Leu 
                485                 490                 495     


Cys Arg Arg Arg Lys Gln Lys Lys Val Ile Tyr Lys Asp Val Glu Leu 
            500                 505                 510         


Asn Ser Phe Asp Pro Arg Gln Ala Phe His Arg 
        515                 520             


<210>  563
<211>  524
<212>  PRT
<213>  Jurona vesiculovirus

<400>  563

Met Glu Ser Leu Pro Phe Ser Ala Leu Leu Ala Val Leu Ser Ile Thr 
1               5                   10                  15      


Leu Cys Asp Ser Ala Ile Pro Ile Phe Phe Pro Ser Glu Pro Gln Leu 
            20                  25                  30          


Glu Trp Lys Pro Val Leu Pro Gly Ser Arg Tyr Cys Pro Gln Ser Asn 
        35                  40                  45              


Glu Met Ser Leu Asp Pro Asp Leu Lys Lys Ser Thr Ile Ser Val Lys 
    50                  55                  60                  


Val Pro Ile Gly Val Thr Pro Ser Lys Ser Asp Gly Tyr Leu Cys His 
65                  70                  75                  80  


Gly Ala Lys Trp Val Ser Thr Cys Asp Phe Arg Trp Tyr Gly Pro Lys 
                85                  90                  95      


Tyr Ile Thr His Ser Ile His Asn Leu Arg Pro Thr Thr Asn Asp Cys 
            100                 105                 110         


Glu Asp Ala Ile Lys Lys Tyr Glu Ala Gly Thr Leu Ile Asn Pro Gly 
        115                 120                 125             


Phe Pro Pro Asp Ser Cys Ala Tyr Ala Thr Val Thr Asp Ser Glu His 
    130                 135                 140                 


Leu Val Ile Leu Ile Thr Pro His His Val Gly Val Asp Asp Tyr Arg 
145                 150                 155                 160 


Gly Ala Trp Val Asp Asp Ser Phe Pro Ser Gly Val Cys Glu Thr Asn 
                165                 170                 175     


Gln Cys Asp Thr Thr His Asn Ser Ser Ile Trp Ile Pro Lys Thr Lys 
            180                 185                 190         


Thr Arg His Asn Ile Cys Ser Gln Thr Phe Ala Asn Leu Ser Val Thr 
        195                 200                 205             


Ile Ser Tyr Arg Glu Gly Gly Ala Met Lys Gly Ala Asp Met Val Phe 
    210                 215                 220                 


His Ser Lys Tyr His Pro His Met Val Gly Gly His Ile Cys Lys Met 
225                 230                 235                 240 


Asn Phe Cys Asn Lys Gln Gly Leu Arg Leu Gln Asn Glu Glu Trp Ile 
                245                 250                 255     


Glu Ile Pro Ser Gly Thr Lys Val Gly Asn Gln Asp Leu Met Asn Leu 
            260                 265                 270         


Phe Ser Asp Cys Lys Ser Gly Leu Glu Val Arg Ser Thr Leu Arg Ser 
        275                 280                 285             


Glu Gly Ala Asn Thr Leu Thr Trp Glu Thr Gln Arg Leu Leu Asp Tyr 
    290                 295                 300                 


Ala Leu Cys Gln Asn Thr Trp Asp Lys Phe Asp Asn Gln Gly Ala Val 
305                 310                 315                 320 


Ser Ala Leu Asp Leu Ser Tyr Leu Ala Ala Arg Ala Pro Gly Lys Gly 
                325                 330                 335     


Val Ala Tyr Thr Met Ile Asn Gly Thr Leu His Ser Ala Pro Thr Arg 
            340                 345                 350         


Tyr Val Arg Met Trp Ile Glu Ser Pro Ser Met Glu Glu Leu Lys Ala 
        355                 360                 365             


Lys Lys Glu Ser Ser Ser Gly Val Glu Thr Ser Ile Trp Asn Gln Trp 
    370                 375                 380                 


Phe Pro Phe Lys Gly Gly Glu Ile Gly Pro Asn Gly Leu Ile Lys Ala 
385                 390                 395                 400 


Gly Asn Lys Tyr Lys Phe Pro Leu Tyr Leu Val Gly Met Gly Met Leu 
                405                 410                 415     


Asp Asp Glu Ile Asn Ala Leu Glu Leu Gly Gly Pro Ile Asp His Pro 
            420                 425                 430         


Gln Arg Ala His Ala Gln Ala Val Leu Gly Asp Glu Glu Thr Leu Phe 
        435                 440                 445             


Phe Gly Asp Thr Gly Val Gly Lys Asn Pro Val Glu Leu Ile Thr Gly 
    450                 455                 460                 


Trp Phe Ser Gly Trp Lys Glu Thr Ile Met Ala Val Val Ala Ile Phe 
465                 470                 475                 480 


Leu Leu Val Ile Val Leu Tyr Gly Val Leu Arg Cys Cys Pro Thr Ile 
                485                 490                 495     


Cys Val Leu Cys Lys Arg Lys Ser Arg His Arg Thr Lys Asp Met Glu 
            500                 505                 510         


Met Gln Tyr Ile Pro Asn Asn Gln Arg His Trp Arg 
        515                 520                 


<210>  564
<211>  521
<212>  PRT
<213>  Malpais Spring vesiculovirus

<400>  564

Met Glu Ser Leu Leu Lys Ala Ile Cys Val Leu Leu Leu Ile His Cys 
1               5                   10                  15      


Ser Arg Cys Asp Leu Pro Ile Val Phe Pro Asp Gln Lys Glu Leu Leu 
            20                  25                  30          


Trp Asn Pro Val Leu Lys Thr Asn Arg Tyr Cys Pro Gln Thr Arg Glu 
        35                  40                  45              


Ile Ala Pro Leu Asp Lys Pro Lys Thr Leu Lys Ile Thr Thr Gly Val 
    50                  55                  60                  


Pro Val Arg Ser Pro Lys Glu Lys Ile Glu Gly Tyr Leu Cys His Ser 
65                  70                  75                  80  


Gly Lys Trp Val Thr Thr Cys Asp Tyr Arg Trp Tyr Gly Ala Lys Tyr 
                85                  90                  95      


Val Thr His Ser Ile His His Leu Lys Pro Thr Asp Gln Met Cys Arg 
            100                 105                 110         


Asp Ala Ile Ser Gln Tyr Asn Gly Gly Thr Leu Leu Asn Pro Gly Phe 
        115                 120                 125             


Pro Pro Glu Val Cys Gly Tyr Ala Ser Val Thr Asp Ser Glu Leu Ile 
    130                 135                 140                 


Ile Thr Leu Ile Thr Pro His Thr Val Gly Val Asp Asp Tyr Arg Gly 
145                 150                 155                 160 


Leu Trp Ile Asp Pro Ser Phe Pro Asn Gly Glu Cys Asn Ser Ile Val 
                165                 170                 175     


Cys Glu Thr Ile His Asn Ser Thr Lys Trp Val Ser Lys Gly Glu Met 
            180                 185                 190         


Pro Thr Asp Ile Cys Gln Gln Thr Phe Thr Thr Ile Lys Met Asp Val 
        195                 200                 205             


Ser Tyr Pro Ser Asp Thr Thr Ser Gln Gly Ser Leu Leu Ser Phe His 
    210                 215                 220                 


Ser Pro Tyr His Pro His Ile Ser Gly Lys Asp Ile Cys Lys Met Ser 
225                 230                 235                 240 


Tyr Cys Gly Ser Asn Gly Leu Arg Leu Pro Asn Gly Glu Trp Phe Ser 
                245                 250                 255     


Ile Ile Asn Thr Ser Lys Ile Gly Asn Lys Asn Leu Ile Asp Phe Phe 
            260                 265                 270         


Ser Pro Cys Lys Ala Gly Val Glu Val Arg Ser Thr Leu Gln Ser Glu 
        275                 280                 285             


Gly Ser Gln Thr Ile Ala Trp Glu Thr Gln Arg Met Leu Asp Tyr Ala 
    290                 295                 300                 


Leu Cys Gln Asn Thr Trp Asp Lys Phe Glu Arg Gly Glu Pro Leu Ser 
305                 310                 315                 320 


Pro Leu Asp Leu Asn Tyr Leu Ala Pro Arg Val Pro Gly Lys Gly Met 
                325                 330                 335     


Ala Tyr Thr Ile Ile Asn Asn Thr Leu His Ser Ser His Ala Val Tyr 
            340                 345                 350         


Arg Arg Val Trp Ile Glu Gly Pro Ile Ile Gly Glu Met Lys Gly Lys 
        355                 360                 365             


Ile Glu Ser Ala Thr Gly Val Ala Lys Glu Ile Trp Ala Gln Trp Phe 
    370                 375                 380                 


Glu Phe Gly Gln Asn Lys Ile Gly Pro Asn Gly Val Ile Lys Thr Asn 
385                 390                 395                 400 


Asp Gly Ile Lys Phe Pro Leu Tyr Ala Ile Gly Thr Gly Leu Ile Asp 
                405                 410                 415     


Gln Asp Ile His Glu Leu Ser Glu Val Ser Pro Met Asp His Pro His 
            420                 425                 430         


Leu Val His Ala Lys Lys Tyr Val Ser Glu Asp Asp Glu Ile Tyr Phe 
        435                 440                 445             


Gly Asp Thr Gly Val Ser His Asn Pro Val Glu Ile Phe Ser Gly Trp 
    450                 455                 460                 


Phe Thr Asn Trp Lys Glu Gly Leu Met Lys Phe Ser Ile Leu Val Leu 
465                 470                 475                 480 


Ser Ile Leu Ile Phe Tyr Val Val Ile Arg Leu Val Met Cys Ile Pro 
                485                 490                 495     


Leu Lys Cys Lys Lys Glu Arg Lys Pro Arg Leu Glu Phe Glu Leu Gln 
            500                 505                 510         


Pro Arg Glu Trp Glu Tyr Ser Arg Ala 
        515                 520     


<210>  565
<211>  512
<212>  PRT
<213>  Maraba vesiculovirus

<400>  565

Met Leu Arg Leu Phe Leu Phe Cys Phe Leu Ala Leu Gly Ala His Ser 
1               5                   10                  15      


Lys Phe Thr Ile Val Phe Pro His His Gln Lys Gly Asn Trp Lys Asn 
            20                  25                  30          


Val Pro Ser Thr Tyr His Tyr Cys Pro Ser Ser Ser Asp Gln Asn Trp 
        35                  40                  45              


His Asn Asp Leu Thr Gly Val Ser Leu His Val Lys Ile Pro Lys Ser 
    50                  55                  60                  


His Lys Ala Ile Gln Ala Asp Gly Trp Met Cys His Ala Ala Lys Trp 
65                  70                  75                  80  


Val Thr Thr Cys Asp Phe Arg Trp Tyr Gly Pro Lys Tyr Ile Thr His 
                85                  90                  95      


Ser Ile His Ser Met Ser Pro Thr Leu Glu Gln Cys Lys Thr Ser Ile 
            100                 105                 110         


Glu Gln Thr Lys Gln Gly Val Trp Ile Asn Pro Gly Phe Pro Pro Gln 
        115                 120                 125             


Ser Cys Gly Tyr Ala Thr Val Thr Asp Ala Glu Val Val Val Val Gln 
    130                 135                 140                 


Ala Thr Pro His His Val Leu Val Asp Glu Tyr Thr Gly Glu Trp Ile 
145                 150                 155                 160 


Asp Ser Gln Leu Val Gly Gly Lys Cys Ser Lys Glu Val Cys Gln Thr 
                165                 170                 175     


Val His Asn Ser Thr Val Trp His Ala Asp Tyr Lys Ile Thr Gly Leu 
            180                 185                 190         


Cys Glu Ser Asn Leu Ala Ser Val Asp Ile Thr Phe Phe Ser Glu Asp 
        195                 200                 205             


Gly Gln Lys Thr Ser Leu Gly Lys Pro Asn Thr Gly Phe Arg Ser Asn 
    210                 215                 220                 


His Phe Ala Tyr Glu Ser Gly Glu Lys Ala Cys Arg Met Gln Tyr Cys 
225                 230                 235                 240 


Thr Gln Trp Gly Ile Arg Leu Pro Ser Gly Val Trp Phe Glu Leu Val 
                245                 250                 255     


Asp Lys Asp Leu Phe Gln Ala Ala Lys Leu Pro Glu Cys Pro Arg Gly 
            260                 265                 270         


Ser Ser Ile Ser Ala Pro Ser Gln Thr Ser Val Asp Val Ser Leu Ile 
        275                 280                 285             


Gln Asp Val Glu Arg Ile Leu Asp Tyr Ser Leu Cys Gln Glu Thr Trp 
    290                 295                 300                 


Ser Lys Ile Arg Ala Lys Leu Pro Val Ser Pro Val Asp Leu Ser Tyr 
305                 310                 315                 320 


Leu Ala Pro Lys Asn Pro Gly Ser Gly Pro Ala Phe Thr Ile Ile Asn 
                325                 330                 335     


Gly Thr Leu Lys Tyr Phe Glu Thr Arg Tyr Ile Arg Val Asp Ile Ser 
            340                 345                 350         


Asn Pro Ile Ile Pro His Met Val Gly Thr Met Ser Gly Thr Thr Thr 
        355                 360                 365             


Glu Arg Glu Leu Trp Asn Asp Trp Tyr Pro Tyr Glu Asp Val Glu Ile 
    370                 375                 380                 


Gly Pro Asn Gly Val Leu Lys Thr Pro Thr Gly Phe Lys Phe Pro Leu 
385                 390                 395                 400 


Tyr Met Ile Gly His Gly Met Leu Asp Ser Asp Leu His Lys Ser Ser 
                405                 410                 415     


Gln Ala Gln Val Phe Glu His Pro His Ala Lys Asp Ala Ala Ser Gln 
            420                 425                 430         


Leu Pro Asp Asp Glu Thr Leu Phe Phe Gly Asp Thr Gly Leu Ser Lys 
        435                 440                 445             


Asn Pro Val Glu Leu Val Glu Gly Trp Phe Ser Ser Trp Lys Ser Thr 
    450                 455                 460                 


Leu Ala Ser Phe Phe Leu Ile Ile Gly Leu Gly Val Ala Leu Ile Phe 
465                 470                 475                 480 


Ile Ile Arg Ile Ile Val Ala Ile Arg Tyr Lys Tyr Lys Gly Arg Lys 
                485                 490                 495     


Thr Gln Lys Ile Tyr Asn Asp Val Glu Met Ser Arg Leu Gly Asn Lys 
            500                 505                 510         


<210>  566
<211>  513
<212>  PRT
<213>  Morreton vesiculovirus

<400>  566

Met Leu Val Leu Tyr Leu Leu Leu Ser Leu Leu Ala Leu Gly Ala Gln 
1               5                   10                  15      


Cys Lys Phe Thr Ile Val Phe Pro His Asn Gln Lys Gly Asn Trp Lys 
            20                  25                  30          


Asn Val Pro Ala Asn Tyr Gln Tyr Cys Pro Ser Ser Ser Asp Leu Asn 
        35                  40                  45              


Trp His Asn Gly Leu Ile Gly Thr Ser Leu Gln Val Lys Met Pro Lys 
    50                  55                  60                  


Ser His Lys Ala Ile Gln Ala Asp Gly Trp Met Cys His Ala Ala Lys 
65                  70                  75                  80  


Trp Val Thr Thr Cys Asp Phe Arg Trp Tyr Gly Pro Lys Tyr Val Thr 
                85                  90                  95      


His Ser Ile Lys Ser Met Ile Pro Thr Val Asp Gln Cys Lys Glu Ser 
            100                 105                 110         


Ile Ala Gln Thr Lys Gln Gly Thr Trp Leu Asn Pro Gly Phe Pro Pro 
        115                 120                 125             


Gln Ser Cys Gly Tyr Ala Ser Val Thr Asp Ala Glu Ala Val Ile Val 
    130                 135                 140                 


Lys Ala Thr Pro His Gln Val Leu Val Asp Glu Tyr Thr Gly Glu Trp 
145                 150                 155                 160 


Val Asp Ser Gln Phe Pro Thr Gly Lys Cys Asn Lys Asp Ile Cys Pro 
                165                 170                 175     


Thr Val His Asn Ser Thr Thr Trp His Ser Asp Tyr Lys Val Thr Gly 
            180                 185                 190         


Leu Cys Asp Ala Asn Leu Ile Ser Met Asp Ile Thr Phe Phe Ser Glu 
        195                 200                 205             


Asp Gly Lys Leu Thr Ser Leu Gly Lys Glu Gly Thr Gly Phe Arg Ser 
    210                 215                 220                 


Asn Tyr Phe Ala Tyr Glu Asn Gly Asp Lys Ala Cys Arg Met Gln Tyr 
225                 230                 235                 240 


Cys Lys His Trp Gly Val Arg Leu Pro Ser Gly Val Trp Phe Glu Met 
                245                 250                 255     


Ala Asp Lys Asp Ile Tyr Asn Asp Ala Lys Phe Pro Asp Cys Pro Glu 
            260                 265                 270         


Gly Ser Ser Ile Ala Ala Pro Ser Gln Thr Ser Val Asp Val Ser Leu 
        275                 280                 285             


Ile Gln Asp Val Glu Arg Ile Leu Asp Tyr Ser Leu Cys Gln Glu Thr 
    290                 295                 300                 


Trp Ser Lys Ile Arg Ala His Leu Pro Ile Ser Pro Val Asp Leu Ser 
305                 310                 315                 320 


Tyr Leu Ser Pro Lys Asn Pro Gly Thr Gly Pro Ala Phe Thr Ile Ile 
                325                 330                 335     


Asn Gly Thr Leu Lys Tyr Phe Glu Thr Arg Tyr Ile Arg Val Asp Ile 
            340                 345                 350         


Ala Gly Pro Ile Ile Pro Gln Met Arg Gly Val Ile Ser Gly Thr Thr 
        355                 360                 365             


Thr Glu Arg Glu Leu Trp Thr Asp Trp Tyr Pro Tyr Glu Asp Val Glu 
    370                 375                 380                 


Ile Gly Pro Asn Gly Val Leu Lys Thr Ala Thr Gly Tyr Lys Phe Pro 
385                 390                 395                 400 


Leu Tyr Met Ile Gly His Gly Met Leu Asp Ser Asp Leu His Ile Ser 
                405                 410                 415     


Ser Lys Ala Gln Val Phe Glu His Pro His Ile Gln Asp Ala Ala Ser 
            420                 425                 430         


Gln Leu Pro Asp Asp Glu Thr Leu Phe Phe Gly Asp Thr Gly Leu Ser 
        435                 440                 445             


Lys Asn Pro Ile Glu Leu Val Glu Gly Trp Phe Ser Gly Trp Lys Ser 
    450                 455                 460                 


Thr Ile Ala Ser Phe Phe Phe Ile Ile Gly Leu Val Ile Gly Leu Tyr 
465                 470                 475                 480 


Leu Val Leu Arg Ile Gly Ile Ala Leu Cys Ile Lys Cys Arg Val Gln 
                485                 490                 495     


Glu Lys Arg Pro Lys Ile Tyr Thr Asp Val Glu Met Asn Arg Leu Asp 
            500                 505                 510         


Arg 
    


<210>  567
<211>  517
<212>  PRT
<213>  New Jersey vesiculovirus

<400>  567

Met Leu Ser Tyr Leu Ile Phe Ala Leu Ala Val Ser Pro Ile Leu Gly 
1               5                   10                  15      


Lys Ile Glu Ile Val Phe Pro Gln His Thr Thr Gly Asp Trp Lys Arg 
            20                  25                  30          


Val Pro His Glu Tyr Asn Tyr Cys Pro Thr Ser Ala Asp Lys Asn Ser 
        35                  40                  45              


His Gly Thr Gln Thr Gly Ile Pro Val Glu Leu Thr Met Pro Lys Gly 
    50                  55                  60                  


Leu Thr Thr His Gln Val Glu Gly Phe Met Cys His Ser Ala Leu Trp 
65                  70                  75                  80  


Met Thr Thr Cys Asp Phe Arg Trp Tyr Gly Pro Lys Tyr Ile Thr His 
                85                  90                  95      


Ser Ile His Asn Glu Glu Pro Thr Asp Tyr Gln Cys Leu Glu Ala Ile 
            100                 105                 110         


Lys Ser Tyr Lys Asp Gly Val Ser Phe Asn Pro Gly Phe Pro Pro Gln 
        115                 120                 125             


Ser Cys Gly Tyr Gly Thr Val Thr Asp Ala Glu Ala His Ile Val Thr 
    130                 135                 140                 


Val Thr Pro His Ser Val Lys Val Asp Glu Tyr Thr Gly Glu Trp Ile 
145                 150                 155                 160 


Asp Pro His Phe Ile Gly Gly Arg Cys Lys Gly Gln Ile Cys Glu Thr 
                165                 170                 175     


Val His Asn Ser Thr Lys Trp Phe Thr Ser Ser Asp Gly Glu Ser Val 
            180                 185                 190         


Cys Ser Gln Leu Phe Thr Leu Val Gly Gly Ile Phe Phe Ser Asp Ser 
        195                 200                 205             


Glu Glu Ile Thr Ser Met Gly Leu Pro Glu Thr Gly Ile Arg Ser Asn 
    210                 215                 220                 


Tyr Phe Pro Tyr Ile Ser Thr Glu Gly Ile Cys Lys Met Pro Phe Cys 
225                 230                 235                 240 


Arg Lys Gln Gly Tyr Lys Leu Lys Asn Asp Leu Trp Phe Gln Ile Met 
                245                 250                 255     


Asp Pro Asp Leu Asp Lys Thr Val Arg Asp Leu Pro His Ile Lys Asp 
            260                 265                 270         


Cys Asp Leu Ser Ser Ser Ile Ile Thr Pro Gly Glu His Ala Thr Asp 
        275                 280                 285             


Ile Ser Leu Ile Ser Asp Val Glu Arg Ile Leu Asp Tyr Ala Leu Cys 
    290                 295                 300                 


Gln Asn Thr Trp Ser Lys Ile Glu Ser Gly Glu Pro Ile Thr Pro Val 
305                 310                 315                 320 


Asp Leu Ser Tyr Leu Gly Pro Lys Asn Pro Gly Val Gly Pro Val Phe 
                325                 330                 335     


Thr Ile Ile Asn Gly Ser Leu His Tyr Phe Thr Ser Lys Tyr Leu Arg 
            340                 345                 350         


Val Glu Leu Glu Ser Pro Val Ile Pro Arg Met Glu Gly Lys Val Ala 
        355                 360                 365             


Gly Thr Arg Ile Val Arg Gln Leu Trp Asp Gln Trp Phe Pro Phe Gly 
    370                 375                 380                 


Glu Val Glu Ile Gly Pro Asn Gly Val Leu Lys Thr Lys Gln Gly Tyr 
385                 390                 395                 400 


Lys Phe Pro Leu His Ile Ile Gly Thr Gly Glu Val Asp Ser Asp Ile 
                405                 410                 415     


Lys Met Glu Arg Val Val Lys His Trp Glu His Pro His Ile Glu Ala 
            420                 425                 430         


Ala Gln Thr Phe Leu Lys Lys Asp Asp Thr Gly Glu Val Leu Tyr Tyr 
        435                 440                 445             


Gly Asp Thr Gly Val Ser Lys Asn Pro Val Glu Leu Val Glu Gly Trp 
    450                 455                 460                 


Phe Ser Gly Trp Arg Ser Ser Leu Met Gly Val Leu Ala Val Ile Ile 
465                 470                 475                 480 


Gly Phe Val Ile Leu Met Phe Leu Ile Lys Leu Ile Gly Val Leu Ser 
                485                 490                 495     


Ser Leu Phe Arg Pro Lys Arg Arg Pro Ile Tyr Lys Ser Asp Val Glu 
            500                 505                 510         


Met Ala His Phe Arg 
        515         


<210>  568
<211>  525
<212>  PRT
<213>  Perinet vesiculovirus

<400>  568

Met Ser Ser Lys Ile Val Leu Ala Ala Ile Cys Leu Cys Ser Val Gln 
1               5                   10                  15      


Tyr Val Ala Cys Ser Phe Gln Ile Val Phe Pro Glu Phe Asn Asn Ala 
            20                  25                  30          


Ala Trp Leu Pro Tyr Leu Lys Thr Ser Arg Tyr Cys Pro Gln Ser Ala 
        35                  40                  45              


Glu Met Glu Phe Glu Arg Arg Val Ser Thr Thr Leu Leu Ser Ala Asp 
    50                  55                  60                  


Val Pro Ile Gly Val Thr Pro Thr Lys Ser Asp Gly Tyr Leu Cys His 
65                  70                  75                  80  


Ala Ala Lys Trp Val Thr Thr Cys Asp Phe Arg Trp Tyr Gly Pro Lys 
                85                  90                  95      


Tyr Val Thr His Ser Ile His Asp Leu Thr Pro Ala Gln Val Asp Cys 
            100                 105                 110         


His Glu Ala Leu Ala Arg Tyr Lys Ala Gly Thr Leu Phe Asn Pro Gly 
        115                 120                 125             


Phe Pro Pro Ala Ser Cys Gly Tyr Ala Thr Ile Thr Asp Ser Glu Gln 
    130                 135                 140                 


Lys Val Val Met Ile Thr Pro His His Val Gly Ile Asp Asp Tyr Arg 
145                 150                 155                 160 


Gly Lys Trp Ile Asp Pro Ile Phe Pro Gly Gly Glu Cys Thr Thr Asn 
                165                 170                 175     


Tyr Cys Glu Thr Leu His Asn Ser Ser Val Trp Leu Pro Ala Asp Glu 
            180                 185                 190         


Lys Ile Val Asp Ile Cys Ala Gln Thr Phe Arg Lys Ile Lys Val Thr 
        195                 200                 205             


Ala Thr Tyr Pro Ser Glu Gly Ala Val Thr Lys Glu Thr Ile Ser Leu 
    210                 215                 220                 


His Ser Ala Tyr His Pro His Val Pro Gly Thr Gly Ile Cys Arg Met 
225                 230                 235                 240 


Thr Tyr Cys Ser Lys Glu Gly Leu Arg Leu Pro Asn Gly Glu Trp Leu 
                245                 250                 255     


Gly Ile Phe Tyr Asp Asn Arg Ile Lys Thr Thr Asp Val Arg Thr Val 
            260                 265                 270         


Phe Pro Ala Cys Pro Asp Gly Leu Glu Val Lys Ser Thr Leu Asn Ser 
        275                 280                 285             


Asp Gly Ala Asn Thr Ile Ala Trp Glu Thr Gln Arg Met Leu Asp Tyr 
    290                 295                 300                 


Ala Leu Cys Gln Ser Thr Trp Asp Lys Val Gln Asn Lys Glu Pro Leu 
305                 310                 315                 320 


Ser Ala Val Asp Leu Ser Tyr Leu Ser Ala Arg Ser Pro Gly Lys Gly 
                325                 330                 335     


Leu Ala Tyr Thr Val Ile Asn Gly Thr Leu His Phe Ala His Val Arg 
            340                 345                 350         


Tyr Val Arg Thr Trp Ile Asp Gly Pro Val Leu Lys Asp Leu Lys Gly 
        355                 360                 365             


Ser Arg Phe Asp Pro Thr Ala Ala Gln Lys Thr Leu Trp Asp Gln Trp 
    370                 375                 380                 


Phe Pro Phe Gly Ser Asn Glu Ile Gly Pro Asn Gly Leu Leu Lys Thr 
385                 390                 395                 400 


Pro Lys Asp Phe Lys Phe Pro Leu Tyr Ile Ile Gly Thr Gly Leu Val 
                405                 410                 415     


Asp Glu Asp Leu Gln Glu Leu Ser Glu Ala Gly Pro Ile Asp His Pro 
            420                 425                 430         


Gln Ile Pro Asp Ala Ser Gly Ile Leu Pro Asn Ser Glu Gln Val Tyr 
        435                 440                 445             


Tyr Gly Asp Thr Gly Val Ser Lys Asn Pro Ile Glu Leu Ile Glu Gly 
    450                 455                 460                 


Trp Phe Ala Asn Trp Lys Glu Thr Val Met Ser Ile Val Gly Leu Val 
465                 470                 475                 480 


Leu Leu Ile Thr Ile Val Phe Thr Val Leu Lys Cys Ile Gly Thr Cys 
                485                 490                 495     


Arg Ser Leu Arg Arg Lys Arg Lys Ile Glu Lys Asp Ile Glu Leu Gln 
            500                 505                 510         


Glu Ile Gly Pro Tyr Gln Pro Thr Thr Tyr Arg Pro Arg 
        515                 520                 525 


<210>  569
<211>  529
<212>  PRT
<213>  Piry vesiculovirus

<400>  569

Met Asp Leu Phe Pro Ile Leu Val Val Val Leu Met Thr Asp Thr Val 
1               5                   10                  15      


Leu Gly Lys Phe Gln Ile Val Phe Pro Asp Gln Asn Glu Leu Glu Trp 
            20                  25                  30          


Arg Pro Val Val Gly Asp Ser Arg His Cys Pro Gln Ser Ser Glu Met 
        35                  40                  45              


Gln Phe Asp Gly Ser Arg Ser Gln Thr Ile Leu Thr Gly Lys Ala Pro 
    50                  55                  60                  


Val Gly Ile Thr Pro Ser Lys Ser Asp Gly Phe Ile Cys His Ala Ala 
65                  70                  75                  80  


Lys Trp Val Thr Thr Cys Asp Phe Arg Trp Tyr Gly Pro Lys Tyr Ile 
                85                  90                  95      


Thr His Ser Ile His His Leu Arg Pro Thr Thr Ser Asp Cys Glu Thr 
            100                 105                 110         


Ala Leu Gln Arg Tyr Lys Asp Gly Ser Leu Ile Asn Leu Gly Phe Pro 
        115                 120                 125             


Pro Glu Ser Cys Gly Tyr Ala Thr Val Thr Asp Ser Glu Ala Met Leu 
    130                 135                 140                 


Val Gln Val Thr Pro His His Val Gly Val Asp Asp Tyr Arg Gly His 
145                 150                 155                 160 


Trp Ile Asp Pro Leu Phe Pro Gly Gly Glu Cys Ser Thr Asn Phe Cys 
                165                 170                 175     


Asp Thr Val His Asn Ser Ser Val Trp Ile Pro Lys Ser Gln Lys Thr 
            180                 185                 190         


Asp Ile Cys Ala Gln Ser Phe Lys Asn Ile Lys Met Thr Ala Ser Tyr 
        195                 200                 205             


Pro Ser Glu Gly Ala Leu Val Ser Asp Arg Phe Ala Phe His Ser Ala 
    210                 215                 220                 


Tyr His Pro Asn Met Pro Gly Ser Thr Val Cys Ile Met Asp Phe Cys 
225                 230                 235                 240 


Glu Gln Lys Gly Leu Arg Phe Thr Asn Gly Glu Trp Met Gly Leu Asn 
                245                 250                 255     


Val Glu Gln Ser Ile Arg Glu Lys Lys Ile Ser Ala Ile Phe Pro Asn 
            260                 265                 270         


Cys Val Ala Gly Thr Glu Ile Arg Ala Thr Leu Glu Ser Glu Gly Ala 
        275                 280                 285             


Arg Thr Leu Thr Trp Glu Thr Gln Arg Met Leu Asp Tyr Ser Leu Cys 
    290                 295                 300                 


Gln Asn Thr Trp Asp Lys Val Ser Arg Lys Glu Pro Leu Ser Pro Leu 
305                 310                 315                 320 


Asp Leu Ser Tyr Leu Ser Pro Arg Ala Pro Gly Lys Gly Met Ala Tyr 
                325                 330                 335     


Thr Val Ile Asn Gly Thr Leu His Ser Ala His Ala Lys Tyr Ile Arg 
            340                 345                 350         


Thr Trp Ile Asp Tyr Gly Glu Met Lys Glu Ile Lys Gly Gly Arg Gly 
        355                 360                 365             


Glu Tyr Ser Lys Ala Pro Glu Leu Leu Trp Ser Gln Trp Phe Asp Phe 
    370                 375                 380                 


Gly Pro Phe Lys Ile Gly Pro Asn Gly Leu Leu His Thr Gly Lys Thr 
385                 390                 395                 400 


Phe Lys Phe Pro Leu Tyr Leu Ile Gly Ala Gly Ile Ile Asp Glu Asp 
                405                 410                 415     


Leu His Glu Leu Asp Glu Ala Ala Pro Ile Asp His Pro Gln Met Pro 
            420                 425                 430         


Asp Ala Lys Ser Val Leu Pro Glu Asp Glu Glu Ile Phe Phe Gly Asp 
        435                 440                 445             


Thr Gly Val Ser Lys Asn Pro Ile Glu Leu Ile Gln Gly Trp Phe Ser 
    450                 455                 460                 


Asn Trp Arg Glu Ser Val Met Ala Ile Val Gly Ile Val Leu Leu Ile 
465                 470                 475                 480 


Val Val Thr Phe Leu Ala Ile Lys Thr Val Arg Val Leu Asn Cys Leu 
                485                 490                 495     


Trp Arg Pro Arg Lys Lys Arg Ile Val Arg Gln Glu Val Asp Val Glu 
            500                 505                 510         


Ser Arg Leu Asn His Phe Glu Met Arg Gly Phe Pro Glu Tyr Val Lys 
        515                 520                 525             


Arg 
    


<210>  570
<211>  556
<212>  PRT
<213>  Radi vesiculovirus

<400>  570

Met Ile Ser Ile Thr Phe Val Tyr Leu Ile Ile Ile Leu Ser Leu Ser 
1               5                   10                  15      


Trp Gly Glu Met Met Ile Pro Phe Pro Asp Val Thr Thr Thr Thr Trp 
            20                  25                  30          


Lys Pro Val Leu Lys Gly Glu His His Cys Pro Ser Ser Ser Asp Val 
        35                  40                  45              


Asp Ile Leu Ser Arg Met Ser Thr Leu Lys Leu Gln Val Arg Ile Pro 
    50                  55                  60                  


Thr Gly Ser Val Ala Ser Lys Ser Asp Gly Leu Leu Cys His Gly Ala 
65                  70                  75                  80  


Lys Trp Val Thr Thr Cys Asp Phe Arg Trp Tyr Gly Ser Lys Tyr Ile 
                85                  90                  95      


Thr His Ser Leu His Ser Ile Arg Pro Thr Leu Ser Gln Cys Thr Glu 
            100                 105                 110         


Ala Ala Lys Ala Tyr Lys Glu Gly Arg Leu Met Ala Pro Gly Phe Pro 
        115                 120                 125             


Pro Glu Ser Cys Gly Trp Asn Ser Val Thr Asp Ser Glu Leu Leu Ser 
    130                 135                 140                 


Ile Leu Val Thr Pro His His Thr Gly Val Asp Asp Tyr Arg Gly Ile 
145                 150                 155                 160 


Trp Ile Asp Ser Met Phe Pro Gly Gly Glu Cys Lys Glu Met Val Cys 
                165                 170                 175     


Asp Thr Val Gln Gly His Thr Ile Trp Met Ser Thr Ser Asn Leu Thr 
            180                 185                 190         


Thr Ala Cys Gly Val Ala Phe Lys Gln Ile Gln Gly Gln Phe Tyr Tyr 
        195                 200                 205             


Leu Asn Ser Gly His Gln Pro Asn Lys Glu Gly Thr Phe Phe His Ser 
    210                 215                 220                 


Pro Asn His Pro Asn Ser Pro Leu Ser Thr Ala Cys Arg Lys Lys Tyr 
225                 230                 235                 240 


Cys Asn Gln Glu Gly Ile Val Ile His Thr Gly Glu Trp Ile Gly Val 
                245                 250                 255     


Pro Trp Asn Thr Arg Ile Arg Asp Val Gln Leu Asp Ser Tyr Thr Asp 
            260                 265                 270         


Leu Cys Ala Glu Ser Thr Glu Ile Lys Ser Thr Ile Gly Ser Ala Pro 
        275                 280                 285             


Ile Arg Val Ile Ala Trp Glu Met Glu Arg Val Met Asp Phe Ala Leu 
    290                 295                 300                 


Cys Gln Thr Val Trp Asp Lys Val Asn Arg Gly Asp Pro Leu Ser Pro 
305                 310                 315                 320 


Leu Asp Leu Ser Tyr Leu Ser Ser Arg Ala Pro Gly Lys Gly Leu Ala 
                325                 330                 335     


Tyr Thr Ile Ile Asn Glu Thr Leu His Val Ala His Val Arg Tyr Ile 
            340                 345                 350         


Arg Thr Tyr Ile Lys Ala Pro Ile Met Glu Glu Ile Lys Gly Ser Arg 
        355                 360                 365             


Gly Asp Arg Ser Ala Ala Glu Ser Val Leu Trp Thr Gln Trp Phe Pro 
    370                 375                 380                 


Tyr Gly Asp Gly Glu Ile Gly Pro Asn Gly Leu Leu Lys Thr Asn Gly 
385                 390                 395                 400 


Ser Phe Lys Phe Pro Phe Tyr Leu Val Gly Met Gly Ala Ile Asp Asp 
                405                 410                 415     


Asp Leu Ile Glu Leu Ser Asn Ala Asp Pro Ile Asp His Pro Gln Lys 
            420                 425                 430         


Ala Ile Ala Ser Val His Leu Asn Thr Asp Glu Glu Leu Phe Phe Gly 
        435                 440                 445             


Asn Thr Gly Ser Asp Ser Asn Pro Val Glu Ala Val Glu Gly Trp Phe 
    450                 455                 460                 


Ala Ser Trp Lys Ser Ala Gly Ile Asn Met Ala Leu Ile Val Leu Cys 
465                 470                 475                 480 


Val Leu Leu Val Leu Ile Phe Leu Arg Ser Leu Pro Ala Leu Ile Lys 
                485                 490                 495     


Leu Ile His Arg Tyr Arg Val Ser Arg Ser Arg Gln Thr Asp Val Glu 
            500                 505                 510         


Leu Asn Ser Ile Asn Glu Thr Ala Arg Thr Gly Ser Val Gly Pro Asp 
        515                 520                 525             


Ile Ile Pro Gly Ala Trp Arg Val His Asp Ser Gly Val Arg Gln Ser 
    530                 535                 540                 


Gln Phe Phe Arg Asn Asn Pro Arg Arg Leu Gly Pro 
545                 550                 555     


<210>  571
<211>  559
<212>  PRT
<213>  Yug Bogdanovac vesiculovirus

<400>  571

Met Ile Ser Ser Thr Leu Ile Leu Val Ile Ile Ser Ala His Ala Phe 
1               5                   10                  15      


Cys Asp Met Ile Ile Pro Phe Pro Asp Val Thr Thr Thr Ser Trp Lys 
            20                  25                  30          


Pro Val Leu Arg Gly Glu His His Cys Pro Ala Ser Asn Asp Leu Asp 
        35                  40                  45              


Met Ala Gly Gly Leu Ser Thr Leu Lys Met Asn Val Lys Ile Pro Ser 
    50                  55                  60                  


Gly Val Val Gly Ser Lys Ser Asp Gly Tyr Leu Cys His Gly Ala Lys 
65                  70                  75                  80  


Trp Val Thr Thr Cys Asp Tyr Arg Trp Tyr Gly Ala Lys Tyr Ile Thr 
                85                  90                  95      


His Ser Leu His Pro Leu Arg Pro Ser Thr Ser Gln Cys Phe Asp Ala 
            100                 105                 110         


Ile Lys Ala Tyr Arg Glu Gly Thr Leu Leu Ser Pro Gly Phe Pro Pro 
        115                 120                 125             


Glu Ser Cys Gly Trp Asn Ser Val Thr Asp Ser Glu Leu Leu Ser Ile 
    130                 135                 140                 


Gln Ile Thr Pro His His Ser Gly Val Asp Asp Tyr Arg Gly Val Trp 
145                 150                 155                 160 


Ile Asp Ser Met Phe Pro Lys Gly Glu Cys Asp Gln Arg Ile Cys Asp 
                165                 170                 175     


Thr Val Gln Glu His Ser Ile Trp Ile Ala Ala Asn Asn Val Ser Ser 
            180                 185                 190         


Ala Cys Ser Ile Ala Phe Lys Gln Leu Glu Gly Tyr Phe Tyr Tyr Arg 
        195                 200                 205             


Asn Ser Gly Ile Gln Pro Asn Lys Asp Gly Thr Phe Phe His Ser Ser 
    210                 215                 220                 


His His Pro Asn Ser Pro Met Ser Ser Cys Cys Arg Ile Lys Tyr Cys 
225                 230                 235                 240 


Asn Gln Glu Gly Leu Arg Leu His Thr Gly Glu Trp Ile Gly Val Ala 
                245                 250                 255     


Trp Asn Thr Lys Ile Arg Asp Val Thr Leu Asp Ser Tyr Thr Asp Thr 
            260                 265                 270         


Cys Pro Gly Gly Thr Glu Val Lys Ser Thr Ile Gly Ser Ser Pro Thr 
        275                 280                 285             


Arg Val Val Ala Trp Glu Met Glu Arg Ile Met Asp Phe Ala Leu Cys 
    290                 295                 300                 


Gln Asn Val Trp Asp Lys Val Asn Arg Gly Glu Gln Leu Ser Pro Leu 
305                 310                 315                 320 


Asp Leu Ser Tyr Leu Ser Ser Arg Ala Pro Gly Lys Gly Leu Ala Tyr 
                325                 330                 335     


Thr Ile Ile Asn Glu Thr Leu His Val Ala His Val Arg Tyr Ile Arg 
            340                 345                 350         


Thr Trp Ile Lys Gly Pro Val Leu Lys Glu Ile Lys Gly Arg Arg Gly 
        355                 360                 365             


Ser Ser Ser Ala Ala Glu Asp Thr Leu Trp Ile Gln Trp Phe Pro Phe 
    370                 375                 380                 


Gly Asp Asn Gln Ile Gly Pro Asn Gly Leu Leu Lys Ser Asn Gly Thr 
385                 390                 395                 400 


Phe Lys Phe Pro Phe Tyr Leu Val Gly Val Gly Ala Leu Asp Glu Asp 
                405                 410                 415     


Leu Ile Glu Met Ala Asn Ala Asp Pro Val Asp His Leu Gln Arg Val 
            420                 425                 430         


Asp Ala Glu Thr His Met Arg Gly Asp Glu Glu Leu Phe Phe Gly Asp 
        435                 440                 445             


Thr Gly Val Ser Lys Asn Pro Ile Glu Ser Val Glu Gly Trp Phe Ser 
    450                 455                 460                 


Asn Trp Ile Ser Gly Leu Phe Asn Ile Ser Ile Ile Val Leu Cys Val 
465                 470                 475                 480 


Leu Ser Val Leu Ile Val Phe Lys Ser Val Ile Thr Leu Ile Arg Val 
                485                 490                 495     


Val Arg Arg Arg Arg Arg Pro Arg Ala Glu Glu Asp Val Glu Leu Asn 
            500                 505                 510         


Asn Met Asn Pro Arg Pro Gln Thr Arg Gln Pro Val Gly Ala Pro Asn 
        515                 520                 525             


Ile Ile Pro Gly Ala Trp Gly Ile Gln Pro Ser His Gly Arg Gly Val 
    530                 535                 540                 


Arg Gln Ser Gln Phe Val Lys Arg Ser Ala Leu Asn Ile Val Thr 
545                 550                 555                 


<210>  572
<211>  514
<212>  PRT
<213>  Zahedan zarhavirus

<400>  572

Met Val Ser Phe Gly Leu Leu Leu Leu Phe Leu Ser Ser Ala Ser Gly 
1               5                   10                  15      


Leu Asn Val Thr Ala Pro Phe Phe Leu Tyr Pro Glu Leu Val Ser Pro 
            20                  25                  30          


Trp Arg Asn Ile Thr Leu Asp His Ala Lys Cys Pro Ile Ser Ser Pro 
        35                  40                  45              


Val Ala Thr Asp Gln Glu Leu Ser Ser Glu Thr Phe Pro Ser Gly His 
    50                  55                  60                  


Gln Glu Leu His His Glu Leu Ala Pro Val Lys Gly Tyr Leu Cys Ser 
65                  70                  75                  80  


Gly Leu Arg Tyr Thr Thr Glu Cys Tyr Glu Gly Phe Leu Gly Gly Lys 
                85                  90                  95      


Asp Ile Lys Lys Thr Ile Asp Lys Val Gln Val Thr Gly Asp Ile Cys 
            100                 105                 110         


Leu Arg Glu Leu Glu Lys Val Lys Thr Gly Ser Val Ile Pro Pro Tyr 
        115                 120                 125             


Phe Pro Ala Pro Glu Cys Ala Trp Met Lys Thr Gln Thr Asn Asp Ala 
    130                 135                 140                 


Val Phe Tyr Ile Ile Glu Glu His Ser Val Ser Tyr Asp Pro Tyr Lys 
145                 150                 155                 160 


Ile Gly Phe Val Asp Pro Ile Phe Leu Lys Asp Ile Cys Val Asn Lys 
                165                 170                 175     


Val Cys Pro Thr Glu His Asp Asn Met Leu Trp Val Thr Glu Ala Asp 
            180                 185                 190         


Val Gly His Gln Cys Ser Glu Phe Leu Asp Ala Glu Ile Thr Phe His 
        195                 200                 205             


Ser Asn Gln Asn Tyr Ser Ile Thr Ile Ile Glu His Gln His Lys Met 
    210                 215                 220                 


Phe Glu Asp Phe Thr Lys Ala Cys Arg Met Thr Tyr Cys Gly Glu Lys 
225                 230                 235                 240 


Gly Val Arg Leu Pro Ser Gly Leu Phe Tyr Thr His Ile Pro Pro Pro 
                245                 250                 255     


Tyr Trp His Asn Ile Asn Glu Cys Ser Val Lys Arg Asn Val Thr Phe 
            260                 265                 270         


Tyr Pro Leu Ser Ala Glu Leu Leu Glu Ile Glu Arg Glu Met Thr Val 
        275                 280                 285             


Asp Arg Glu Arg Met Met Cys Ile Glu Ser Leu Gln Thr Ala Arg Arg 
    290                 295                 300                 


Thr Lys Val Met Thr Phe Leu Thr Leu Ser Tyr Leu Val Pro Lys Phe 
305                 310                 315                 320 


Glu Gly Arg Phe Pro Val Tyr Arg Leu Glu Lys Gly Gln Leu Lys Gly 
                325                 330                 335     


Ala Val Ala Asn Trp His Ala Leu Lys Thr Val Lys Pro Gly Thr Ser 
            340                 345                 350         


Arg Gln Ile Gly Thr Phe Pro Asn Gly Thr Asn Ala Tyr Trp Trp Asp 
        355                 360                 365             


Trp Val Asp Ser Gly Tyr Pro Gly Ile Asp Ser Gly Phe Asn Gly Val 
    370                 375                 380                 


His Arg Thr Glu Gly Lys Val Val Ile Pro Arg Leu Glu Val Leu Lys 
385                 390                 395                 400 


Lys Glu Tyr Ala Leu Ser Leu Asp Ile Leu His Glu Met Arg Thr Ile 
                405                 410                 415     


Glu His Pro Ile Ile Lys His Leu Ala Arg Glu Asn Leu Thr Gly His 
            420                 425                 430         


Leu Thr Thr Leu Glu Gly Arg Asp Ser Ile Asp Val Gly Glu Trp Leu 
        435                 440                 445             


Ser Asn Leu Trp Glu Lys Ile Trp Gly Lys Leu Leu Leu Leu Gly Cys 
    450                 455                 460                 


Leu Cys Gly Phe Leu Leu Val Val Cys Cys Cys Cys Phe Gly Arg Ile 
465                 470                 475                 480 


Arg Arg Cys Leu Ser Thr Thr Ser Arg Gln Asn Asn Asp Ile Glu Met 
                485                 490                 495     


Leu Pro Leu Arg Thr Asn Leu Glu Thr Val Lys Ile Asp Arg Pro Val 
            500                 505                 510         


His Trp 
        


<210>  573
<211>  607
<212>  PRT
<213>  Reptile sunshinevirus 1

<400>  573

Met Glu Asn Gln His Ile Ile Ile Lys Lys Lys Lys Lys Gly Lys Lys 
1               5                   10                  15      


Gly Lys Lys Asn Lys Lys Glu Arg Lys Lys Lys Gly Lys Arg Glu Lys 
            20                  25                  30          


Glu Arg Glu Lys Lys Ser Thr Pro Lys Pro Gln Leu Lys Pro Lys Ile 
        35                  40                  45              


Leu Thr Asn Leu Arg Gly Asp Ser Pro Met Glu Thr Pro Gln Leu Phe 
    50                  55                  60                  


Ser Gly Arg Thr Gly His Gln Trp Ser Arg Arg Tyr Ile Arg Tyr Asn 
65                  70                  75                  80  


Tyr Phe Leu Thr Leu Thr Leu Leu Thr Val Ile Phe Ala Asp His Gln 
                85                  90                  95      


Glu Leu Thr Gln Asn Ser Asp Ile Ile Val Ser Thr Val Ala Leu Glu 
            100                 105                 110         


Thr Arg Val Val Ser Val Gln Thr Gly Ser Ser Trp Phe Leu Leu Arg 
        115                 120                 125             


Val Asn Thr Thr Phe Lys Asn Asp Gly Leu Thr Ser Arg Cys Thr Lys 
    130                 135                 140                 


Leu Gly Glu Asn Phe Val Ser His Val Asn Glu Phe Gln Glu Asn Ile 
145                 150                 155                 160 


Lys Ile Thr Ala Ser Ser Leu Ile Pro Lys Gln Ala Ile Leu Glu Val 
                165                 170                 175     


Asn Thr Ala Lys Asn Leu Val Ser Ala Leu Thr Arg Thr Thr Arg Ser 
            180                 185                 190         


Asn Arg Arg Lys Arg Leu Ala Gly Ala Ala Ile Ala Val Ala Ala Val 
        195                 200                 205             


Ala Ile Ser Gly Ala Ala Leu Val Thr Ala Gly Ile Ala Leu Ala Glu 
    210                 215                 220                 


Thr Arg Thr Leu Ala Ala Ser Val Asp Ser Val Ile Ser Gly Ala Glu 
225                 230                 235                 240 


Lys Thr Asn Ala Ala Leu Asn Gln Leu Thr Gln Thr Met Lys Ser Phe 
                245                 250                 255     


Thr Lys Glu Thr Gln Asp Asn Ile Ser Thr Leu Ala Lys Glu Ile Ser 
            260                 265                 270         


Glu Ala Asn Lys Arg Ile Asp Cys Leu Glu Tyr Tyr Thr Glu Val Lys 
        275                 280                 285             


Asn Gln Phe Leu Asp Phe Thr Ser Tyr Asn Tyr Glu Ile Leu Gln Ala 
    290                 295                 300                 


Ser Met Ser Lys Asn Gly Gly Ile Pro Leu Arg Leu Met Lys Arg Ile 
305                 310                 315                 320 


Met Val Pro Asn Pro Gln Met Thr Ala Gln Ser Asn Thr Ile Glu Glu 
                325                 330                 335     


Leu Val Leu Arg Arg Gly Arg Ile Arg Leu Leu Ala Tyr Thr Asn Ser 
            340                 345                 350         


Thr Leu Thr Tyr Arg Ile Asp Val Pro Arg Phe Ala Ser Met Gly Lys 
        355                 360                 365             


Ile Ser Pro Leu Leu Ile Ser Val Asp Glu Pro Ile Ser Leu Ile Gly 
    370                 375                 380                 


Ser Gly Ile Tyr Thr Ser Ile Leu Ser Val Asp Leu Gly Ile Val Leu 
385                 390                 395                 400 


Leu Asp Cys Glu Glu Asp Asn Ile Ser Tyr Leu Cys Ser Ser Ser Ser 
                405                 410                 415     


Pro Ser Asp Ala Ile Val Lys Asn Cys Leu Lys Asp Ser Thr Ala Asp 
            420                 425                 430         


Cys Ile Ser Ala Leu Gln Glu Ser Gly Ala Lys Lys Gly Lys Tyr Phe 
        435                 440                 445             


Val Tyr Gln Ser Gly Phe Leu Val Ser Arg Cys Ser Gln Gln Val Cys 
    450                 455                 460                 


Thr Cys Leu Glu Pro Glu Ile Arg Arg Ile Tyr Val Ser His Pro Leu 
465                 470                 475                 480 


Ser Lys Glu Thr Ser Gln Cys Thr Gln Val Ser Ile Lys Thr Gln Asp 
                485                 490                 495     


Gln Thr Phe Arg Leu Leu Leu Thr Ser Val Lys Ala Ala Gly Ile Ile 
            500                 505                 510         


Asn Ile Gln Ala Pro Thr Glu Ile Lys Arg Lys Thr Trp Lys Asp Ile 
        515                 520                 525             


Gly Leu Thr Phe Gly Lys Tyr Asn Thr Lys Phe Glu Glu Ile Glu Glu 
    530                 535                 540                 


Leu Ile Glu Asn Ser Asn Gly Asp Leu Glu Lys Ala Arg Thr Tyr Leu 
545                 550                 555                 560 


Val Leu Ser Gln Asn Leu Lys Val Val Val Ile Val Thr Ser Ile Val 
                565                 570                 575     


Ile Ala Phe Leu Ile Leu Phe Val Ile Phe Ile Leu Lys Arg Ile Tyr 
            580                 585                 590         


Asp Leu Lys Asn Arg Val Thr Lys Ile Glu Val Tyr Leu Glu Arg 
        595                 600                 605         


<210>  574
<211>  977
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  574

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  575
<211>  977
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  575

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  576
<211>  977
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  576

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  577
<211>  977
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  577

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  578
<211>  977
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  578

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  579
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  579

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Val 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His 
        195                 200                 205             


Pro Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser 
225                 230                 235                 240 


Phe Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile 
                245                 250                 255     


Lys Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala 
            260                 265                 270         


Asn Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu 
305                 310                 315                 320 


Ala Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  580
<211>  977
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  580

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  581
<211>  977
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  581

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  582
<211>  977
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  582

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  583
<211>  977
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  583

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Ser Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  584
<211>  977
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  584

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  585
<211>  977
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  585

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Ser Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  586
<211>  977
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  586

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Leu Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  587
<211>  977
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  587

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Leu Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  588
<211>  977
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  588

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Ser Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Leu Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  589
<211>  977
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  589

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Leu Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  590
<211>  977
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  590

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Leu Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  591
<211>  977
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  591

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Leu Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  592
<211>  977
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  592

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Ser Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Leu Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  593
<211>  977
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  593

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  594
<211>  977
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  594

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  595
<211>  977
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  595

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asn Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  596
<211>  977
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  596

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asn Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  597
<211>  977
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  597

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asn Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  598
<211>  977
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  598

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asn Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  599
<211>  977
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  599

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asn Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  600
<211>  977
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  600

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Lys Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Pro Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  601
<211>  977
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  601

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Lys Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Pro Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  602
<211>  977
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  602

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Lys Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Pro Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  603
<211>  977
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  603

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Lys Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Pro Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  604
<211>  977
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  604

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Lys Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Pro Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  605
<211>  977
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  605

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Pro Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  606
<211>  977
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  606

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Lys Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Pro Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  607
<211>  976
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  607

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu 
            100                 105                 110         


Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala 
                165                 170                 175     


Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala 
            180                 185                 190         


Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro Val 
        195                 200                 205             


Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro Val 
    210                 215                 220                 


Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe Leu 
225                 230                 235                 240 


Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys Lys 
                245                 250                 255     


Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn Gly 
            260                 265                 270         


Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys Glu 
        275                 280                 285             


Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp Val 
    290                 295                 300                 


Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala Lys 
305                 310                 315                 320 


Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg 
                325                 330                 335     


Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys 
            340                 345                 350         


Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu 
        355                 360                 365             


Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu 
    370                 375                 380                 


Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly Asp 
385                 390                 395                 400 


Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val 
                405                 410                 415     


Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser 
            420                 425                 430         


Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser 
        435                 440                 445             


Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile 
    450                 455                 460                 


Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu 
465                 470                 475                 480 


Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile 
                485                 490                 495     


Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr 
            500                 505                 510         


Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu 
        515                 520                 525             


Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys 
    530                 535                 540                 


Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn 
545                 550                 555                 560 


Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp 
                565                 570                 575     


Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly 
            580                 585                 590         


Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu 
        595                 600                 605             


Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg 
    610                 615                 620                 


Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg 
625                 630                 635                 640 


Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly 
                645                 650                 655     


Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro 
            660                 665                 670         


Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr 
        675                 680                 685             


His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile 
    690                 695                 700                 


Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg 
705                 710                 715                 720 


Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn 
                725                 730                 735     


Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu 
            740                 745                 750         


Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr 
        755                 760                 765             


Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala 
    770                 775                 780                 


Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu 
785                 790                 795                 800 


Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr 
                805                 810                 815     


Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr 
            820                 825                 830         


Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln 
        835                 840                 845             


Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu 
    850                 855                 860                 


Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile 
865                 870                 875                 880 


Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys 
                885                 890                 895     


Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn 
            900                 905                 910         


Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala 
        915                 920                 925             


Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr 
    930                 935                 940                 


Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp 
945                 950                 955                 960 


Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
                965                 970                 975     


<210>  608
<211>  977
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  608

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  609
<211>  977
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  609

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  610
<211>  977
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  610

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  611
<211>  977
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  611

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  612
<211>  977
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  612

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  613
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  613

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Met Ser Ser Gly 
        115                 120                 125             


Phe Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu 
    130                 135                 140                 


Gln Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys 
145                 150                 155                 160 


Asn Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro 
                165                 170                 175     


Glu Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His 
        195                 200                 205             


Pro Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser 
225                 230                 235                 240 


Phe Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile 
                245                 250                 255     


Lys Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala 
            260                 265                 270         


Asn Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu 
305                 310                 315                 320 


Ala Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  614
<211>  977
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  614

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  615
<211>  977
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  615

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  616
<211>  977
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  616

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  617
<211>  977
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  617

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  618
<211>  977
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  618

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  619
<211>  977
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  619

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  620
<211>  977
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  620

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  621
<211>  976
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  621

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu 
            100                 105                 110         


Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala 
                165                 170                 175     


Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala 
            180                 185                 190         


Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro Val 
        195                 200                 205             


Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val 
    210                 215                 220                 


Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu 
225                 230                 235                 240 


Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys Gly 
                245                 250                 255     


Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn 
            260                 265                 270         


Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu 
        275                 280                 285             


Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp Val 
    290                 295                 300                 


Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys 
305                 310                 315                 320 


Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg 
                325                 330                 335     


Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys 
            340                 345                 350         


Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu 
        355                 360                 365             


Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu 
    370                 375                 380                 


Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly Asp 
385                 390                 395                 400 


Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val 
                405                 410                 415     


Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser 
            420                 425                 430         


Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser 
        435                 440                 445             


Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile 
    450                 455                 460                 


Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu 
465                 470                 475                 480 


Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile 
                485                 490                 495     


Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr 
            500                 505                 510         


Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu 
        515                 520                 525             


Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys 
    530                 535                 540                 


Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn 
545                 550                 555                 560 


Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp 
                565                 570                 575     


Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly 
            580                 585                 590         


Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu 
        595                 600                 605             


Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg 
    610                 615                 620                 


Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg 
625                 630                 635                 640 


Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly 
                645                 650                 655     


Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro 
            660                 665                 670         


Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr 
        675                 680                 685             


His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile 
    690                 695                 700                 


Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg 
705                 710                 715                 720 


Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn 
                725                 730                 735     


Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu 
            740                 745                 750         


Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr 
        755                 760                 765             


Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala 
    770                 775                 780                 


Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu 
785                 790                 795                 800 


Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr 
                805                 810                 815     


Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr 
            820                 825                 830         


Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln 
        835                 840                 845             


Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu 
    850                 855                 860                 


Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile 
865                 870                 875                 880 


Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys 
                885                 890                 895     


Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn 
            900                 905                 910         


Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala 
        915                 920                 925             


Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr 
    930                 935                 940                 


Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp 
945                 950                 955                 960 


Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
                965                 970                 975     


<210>  622
<211>  976
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  622

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu 
            100                 105                 110         


Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala 
                165                 170                 175     


Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala 
            180                 185                 190         


Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro Val 
        195                 200                 205             


Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val 
    210                 215                 220                 


Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu 
225                 230                 235                 240 


Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys Gly 
                245                 250                 255     


Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn 
            260                 265                 270         


Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu 
        275                 280                 285             


Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp Val 
    290                 295                 300                 


Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys 
305                 310                 315                 320 


Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg 
                325                 330                 335     


Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys 
            340                 345                 350         


Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu 
        355                 360                 365             


Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu 
    370                 375                 380                 


Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp 
385                 390                 395                 400 


Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val 
                405                 410                 415     


Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser 
            420                 425                 430         


Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser 
        435                 440                 445             


Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile 
    450                 455                 460                 


Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu 
465                 470                 475                 480 


Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile 
                485                 490                 495     


Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr 
            500                 505                 510         


Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu 
        515                 520                 525             


Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys 
    530                 535                 540                 


Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn 
545                 550                 555                 560 


Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp 
                565                 570                 575     


Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly 
            580                 585                 590         


Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu 
        595                 600                 605             


Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg 
    610                 615                 620                 


Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg 
625                 630                 635                 640 


Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly 
                645                 650                 655     


Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro 
            660                 665                 670         


Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr 
        675                 680                 685             


His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile 
    690                 695                 700                 


Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg 
705                 710                 715                 720 


Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn 
                725                 730                 735     


Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu 
            740                 745                 750         


Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr 
        755                 760                 765             


Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala 
    770                 775                 780                 


Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu 
785                 790                 795                 800 


Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr 
                805                 810                 815     


Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr 
            820                 825                 830         


Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln 
        835                 840                 845             


Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp Leu 
    850                 855                 860                 


Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile 
865                 870                 875                 880 


Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys 
                885                 890                 895     


Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn 
            900                 905                 910         


Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala 
        915                 920                 925             


Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr 
    930                 935                 940                 


Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp 
945                 950                 955                 960 


Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
                965                 970                 975     


<210>  623
<211>  976
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  623

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu 
            100                 105                 110         


Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala 
                165                 170                 175     


Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala 
            180                 185                 190         


Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro Val 
        195                 200                 205             


Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val 
    210                 215                 220                 


Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu 
225                 230                 235                 240 


Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys Gly 
                245                 250                 255     


Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn 
            260                 265                 270         


Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu 
        275                 280                 285             


Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp Val 
    290                 295                 300                 


Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys 
305                 310                 315                 320 


Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg 
                325                 330                 335     


Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys 
            340                 345                 350         


Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu 
        355                 360                 365             


Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu 
    370                 375                 380                 


Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp 
385                 390                 395                 400 


Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val 
                405                 410                 415     


Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser 
            420                 425                 430         


Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser 
        435                 440                 445             


Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile 
    450                 455                 460                 


Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu 
465                 470                 475                 480 


Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile 
                485                 490                 495     


Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr 
            500                 505                 510         


Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu 
        515                 520                 525             


Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys 
    530                 535                 540                 


Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn 
545                 550                 555                 560 


Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp 
                565                 570                 575     


Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly 
            580                 585                 590         


Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu 
        595                 600                 605             


Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg 
    610                 615                 620                 


Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg 
625                 630                 635                 640 


Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly 
                645                 650                 655     


Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro 
            660                 665                 670         


Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr 
        675                 680                 685             


His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile 
    690                 695                 700                 


Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg 
705                 710                 715                 720 


Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn 
                725                 730                 735     


Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu 
            740                 745                 750         


Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr 
        755                 760                 765             


Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala 
    770                 775                 780                 


Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu 
785                 790                 795                 800 


Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr 
                805                 810                 815     


Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr 
            820                 825                 830         


Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln 
        835                 840                 845             


Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp Leu 
    850                 855                 860                 


Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile 
865                 870                 875                 880 


Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys 
                885                 890                 895     


Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn 
            900                 905                 910         


Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala 
        915                 920                 925             


Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr 
    930                 935                 940                 


Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp 
945                 950                 955                 960 


Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
                965                 970                 975     


<210>  624
<211>  976
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  624

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu 
            100                 105                 110         


Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala 
                165                 170                 175     


Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala 
            180                 185                 190         


Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro Val 
        195                 200                 205             


Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val 
    210                 215                 220                 


Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu 
225                 230                 235                 240 


Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys Gly 
                245                 250                 255     


Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn 
            260                 265                 270         


Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu 
        275                 280                 285             


Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp Val 
    290                 295                 300                 


Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys 
305                 310                 315                 320 


Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg 
                325                 330                 335     


Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys 
            340                 345                 350         


Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu 
        355                 360                 365             


Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu 
    370                 375                 380                 


Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp 
385                 390                 395                 400 


Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val 
                405                 410                 415     


Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser 
            420                 425                 430         


Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser 
        435                 440                 445             


Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile 
    450                 455                 460                 


Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu 
465                 470                 475                 480 


Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile 
                485                 490                 495     


Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr 
            500                 505                 510         


Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu 
        515                 520                 525             


Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys 
    530                 535                 540                 


Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn 
545                 550                 555                 560 


Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp 
                565                 570                 575     


Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly 
            580                 585                 590         


Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu 
        595                 600                 605             


Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg 
    610                 615                 620                 


Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg 
625                 630                 635                 640 


Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly 
                645                 650                 655     


Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro 
            660                 665                 670         


Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr 
        675                 680                 685             


His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile 
    690                 695                 700                 


Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg 
705                 710                 715                 720 


Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn 
                725                 730                 735     


Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu 
            740                 745                 750         


Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr 
        755                 760                 765             


Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala 
    770                 775                 780                 


Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu 
785                 790                 795                 800 


Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr 
                805                 810                 815     


Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr 
            820                 825                 830         


Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln 
        835                 840                 845             


Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu 
    850                 855                 860                 


Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile 
865                 870                 875                 880 


Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys 
                885                 890                 895     


Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn 
            900                 905                 910         


Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala 
        915                 920                 925             


Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr 
    930                 935                 940                 


Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp 
945                 950                 955                 960 


Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
                965                 970                 975     


<210>  625
<211>  977
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  625

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  626
<211>  977
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  626

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  627
<211>  977
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  627

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  628
<211>  977
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  628

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  629
<211>  977
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  629

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  630
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  630

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Gly Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  631
<211>  986
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  631

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Val Val Glu 
                325                 330                 335     


Arg Arg Glu Asn Glu Val Asp Trp Trp Asn Thr Ile Asn Glu Val Lys 
            340                 345                 350         


Lys Leu Ile Asp Ala Lys Arg Asp Met Gly Arg Val Phe Trp Ser Gly 
        355                 360                 365             


Val Thr Ala Glu Lys Arg Asn Thr Ile Leu Glu Gly Tyr Asn Tyr Leu 
    370                 375                 380                 


Pro Asn Glu Asn Asp His Lys Lys Arg Glu Gly Ser Leu Glu Asn Pro 
385                 390                 395                 400 


Lys Lys Pro Ala Lys Arg Gln Phe Gly Asp Leu Leu Leu Tyr Leu Glu 
                405                 410                 415     


Lys Lys Tyr Ala Gly Asp Trp Gly Lys Val Phe Asp Glu Ala Trp Glu 
            420                 425                 430         


Arg Ile Asp Lys Lys Ile Ala Gly Leu Thr Ser His Ile Glu Arg Glu 
        435                 440                 445             


Glu Ala Arg Asn Ala Glu Asp Ala Gln Ser Lys Ala Val Leu Thr Asp 
    450                 455                 460                 


Trp Leu Arg Ala Lys Ala Ser Phe Val Leu Glu Arg Leu Lys Glu Met 
465                 470                 475                 480 


Asp Glu Lys Glu Phe Tyr Ala Cys Glu Ile Gln Leu Gln Lys Trp Tyr 
                485                 490                 495     


Gly Asp Leu Arg Gly Asn Pro Phe Ala Val Glu Ala Glu Asn Ser Ile 
            500                 505                 510         


Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn Cys Ala Phe Ile Trp 
        515                 520                 525             


Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr Leu Ile Ile Asn Tyr 
    530                 535                 540                 


Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile Lys Pro Glu Ala Phe 
545                 550                 555                 560 


Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys Lys Ser Gly Glu Ile 
                565                 570                 575     


Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp Pro Asn Leu Ile Ile 
            580                 585                 590         


Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg Glu Phe Ile Trp Asn 
        595                 600                 605             


Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys Leu Ala Asn Gly Arg 
    610                 615                 620                 


Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr Arg Gln Asp Glu Pro 
625                 630                 635                 640 


Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val Leu Asp Ser 
                645                 650                 655     


Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Ile Asp Arg Gly Glu Asn 
            660                 665                 670         


Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys Pro Leu Ser 
        675                 680                 685             


Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His Ile Leu Arg Ile Gly 
    690                 695                 700                 


Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln Ala Lys Lys Glu Val 
705                 710                 715                 720 


Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Tyr Ala Ser Lys Ala 
                725                 730                 735     


Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr Ala Arg Asp Leu Leu 
            740                 745                 750         


Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile Phe Glu Asn Leu Ser 
        755                 760                 765             


Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Ala Glu Arg Gln 
    770                 775                 780                 


Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys Leu Ala Tyr Glu Gly 
785                 790                 795                 800 


Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln Tyr Thr Ser Lys 
                805                 810                 815     


Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser Ala Asp Tyr Asp Arg 
            820                 825                 830         


Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly Trp Met Thr Thr Ile 
        835                 840                 845             


Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile Thr Tyr Tyr Asn Arg 
    850                 855                 860                 


Tyr Lys Arg Gln Asn Val Val Lys Asp Leu Ser Val Glu Leu Asp Arg 
865                 870                 875                 880 


Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser Ser Trp Thr Lys Gly 
                885                 890                 895     


Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys Arg Phe Ser His Arg 
            900                 905                 910         


Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys Gly Phe Glu Thr His 
        915                 920                 925             


Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser Trp Leu Phe Leu 
    930                 935                 940                 


Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn Lys Thr Thr Gly Asn 
945                 950                 955                 960 


Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln Ser Phe Tyr Arg Lys 
                965                 970                 975     


Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
            980                 985     


<210>  632
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  632

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Val Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Pro Glu Phe Lys Asp Ser Ser Gly Gly Pro 
        675                 680                 685             


Thr Asp Ile Leu Arg Ile Gly Glu Gly Tyr Lys Glu Lys Gln Arg Ala 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Phe Ala Ser Lys Ser Arg Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Ser Ala Arg Asp Leu Phe Tyr His Ala Val Thr His Asp Ala Val 
            740                 745                 750         


Leu Val Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Thr Glu Arg Gln Tyr Thr Lys Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Thr Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  633
<211>  972
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  633

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Asn Ser Asn Ser Thr Glu Phe Lys Ser 
    930                 935                 940                 


Tyr Lys Ser Gly Lys Gln Pro Phe Val Gly Ala Trp Gln Ala Phe Tyr 
945                 950                 955                 960 


Lys Arg Arg Leu Lys Glu Val Trp Lys Pro Asn Ala 
                965                 970         


<210>  634
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  634

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


His Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  635
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  635

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  636
<211>  977
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  636

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn His Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  637
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  637

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Ala 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  638
<211>  979
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  638

Arg Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly 
    210                 215                 220                 


Ala Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala 
225                 230                 235                 240 


Ser Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val 
                245                 250                 255     


Val Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly 
            260                 265                 270         


Lys Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His 
        275                 280                 285             


Thr Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg 
    290                 295                 300                 


Met Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp 
305                 310                 315                 320 


Asp Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu 
                325                 330                 335     


Val Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn 
            340                 345                 350         


Val Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp 
        355                 360                 365             


Gln Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu 
    370                 375                 380                 


Ser Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln 
385                 390                 395                 400 


Leu Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp 
                405                 410                 415     


Gly Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu 
            420                 425                 430         


Gly Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp 
        435                 440                 445             


Ala Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser 
    450                 455                 460                 


Phe Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg 
465                 470                 475                 480 


Cys Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro 
                485                 490                 495     


Phe Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser 
            500                 505                 510         


Lys Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys 
        515                 520                 525             


Leu Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg 
    530                 535                 540                 


Phe Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr 
545                 550                 555                 560 


Val Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe 
                565                 570                 575     


Asn Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys 
            580                 585                 590         


Arg Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr 
        595                 600                 605             


Gly Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr 
    610                 615                 620                 


Asn Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr 
625                 630                 635                 640 


Phe Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn 
                645                 650                 655     


Leu Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu 
            660                 665                 670         


Thr Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly 
        675                 680                 685             


Asn Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln 
    690                 695                 700                 


Arg Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly 
705                 710                 715                 720 


Tyr Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met 
                725                 730                 735     


Val Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp 
            740                 745                 750         


Ala Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly 
        755                 760                 765             


Lys Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp 
    770                 775                 780                 


Leu Thr Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  639
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  639

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Gln Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  640
<211>  977
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  640

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Thr Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  641
<211>  977
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  641

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Arg Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  642
<211>  977
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  642

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Tyr Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  643
<211>  977
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  643

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


His Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  644
<211>  977
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  644

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Ala Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  645
<211>  977
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  645

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  646
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  646

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Arg Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  647
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  647

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Tyr Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  648
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  648

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Asn Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  649
<211>  979
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  649

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Trp Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  650
<211>  979
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  650

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Tyr Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  651
<211>  979
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  651

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Arg Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  652
<211>  979
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  652

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Arg Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Tyr 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  653
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  653

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser His Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  654
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  654

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Ser Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  655
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  655

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Thr Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  656
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  656

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Ala Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  657
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  657

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Val Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  658
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  658

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Leu Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  659
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  659

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asn Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  660
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  660

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Gln Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  661
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  661

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Ser Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  662
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  662

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Ala Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  663
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  663

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Gly Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  664
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  664

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Thr Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  665
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  665

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Arg Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  666
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  666

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu His 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  667
<211>  979
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  667

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Glu Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  668
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  668

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Ile Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  669
<211>  979
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  669

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Phe Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  670
<211>  979
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  670

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Trp Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  671
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  671

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Asp Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  672
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  672

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Thr Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  673
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  673

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Asp Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  674
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  674

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Pro Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  675
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  675

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Lys Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  676
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  676

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Lys Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  677
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  677

Gln Glu Gly Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  678
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  678

Gln Glu Glu Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  679
<211>  979
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  679

Gln Glu Ile Gly Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  680
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  680

Gln Glu Ile Gly Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  681
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  681

Gln Glu Ile Ser Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  682
<211>  979
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  682

Gln Glu Ile Lys Gly Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  683
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  683

Gln Glu Ile Lys Ser Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  684
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  684

Gln Glu Ile Lys Arg Ala Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  685
<211>  979
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  685

Gln Glu Ile Lys Arg Gly Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  686
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  686

Gln Glu Ile Lys Arg Ile Ser Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  687
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  687

Gln Glu Ile Lys Arg Ile Asn Gly Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  688
<211>  979
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  688

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Phe 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  689
<211>  979
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  689

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Phe Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  690
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  690

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Pro Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  691
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  691

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Pro Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  692
<211>  979
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  692

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  693
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  693

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Pro Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  694
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  694

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Ser Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  695
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  695

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Gln Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  696
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  696

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Thr His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  697
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  697

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Gly Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  698
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  698

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Asp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  699
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  699

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Ala Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  700
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  700

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Arg Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  701
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  701

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Lys Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  702
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  702

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Tyr Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  703
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  703

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ser Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  704
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  704

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Pro Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  705
<211>  977
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  705

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Pro Val 
    210                 215                 220                 


Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu 
225                 230                 235                 240 


Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys Gly 
                245                 250                 255     


Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn 
            260                 265                 270         


Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu 
        275                 280                 285             


Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp Val 
    290                 295                 300                 


Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys 
305                 310                 315                 320 


Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg 
                325                 330                 335     


Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys 
            340                 345                 350         


Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu 
        355                 360                 365             


Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu 
    370                 375                 380                 


Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp 
385                 390                 395                 400 


Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val 
                405                 410                 415     


Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser 
            420                 425                 430         


Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser 
        435                 440                 445             


Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile 
    450                 455                 460                 


Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu 
465                 470                 475                 480 


Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile 
                485                 490                 495     


Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr 
            500                 505                 510         


Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu 
        515                 520                 525             


Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys 
    530                 535                 540                 


Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn 
545                 550                 555                 560 


Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp 
                565                 570                 575     


Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly 
            580                 585                 590         


Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu 
        595                 600                 605             


Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg 
    610                 615                 620                 


Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg 
625                 630                 635                 640 


Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly 
                645                 650                 655     


Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro 
            660                 665                 670         


Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr 
        675                 680                 685             


His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile 
    690                 695                 700                 


Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg 
705                 710                 715                 720 


Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn 
                725                 730                 735     


Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu 
            740                 745                 750         


Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr 
        755                 760                 765             


Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala 
    770                 775                 780                 


Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  706
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  706

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Ser Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  707
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  707

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Gly 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  708
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  708

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Ser 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  709
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  709

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Leu Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  710
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  710

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Thr Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  711
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  711

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Trp Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  712
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  712

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Asn Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  713
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  713

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Gln Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  714
<211>  979
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  714

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Ala Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  715
<211>  977
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  715

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Glu Arg 
                325                 330                 335     


Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys 
            340                 345                 350         


Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu 
        355                 360                 365             


Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu 
    370                 375                 380                 


Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp 
385                 390                 395                 400 


Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val 
                405                 410                 415     


Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser 
            420                 425                 430         


Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser 
        435                 440                 445             


Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile 
    450                 455                 460                 


Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu 
465                 470                 475                 480 


Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile 
                485                 490                 495     


Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr 
            500                 505                 510         


Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu 
        515                 520                 525             


Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys 
    530                 535                 540                 


Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn 
545                 550                 555                 560 


Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp 
                565                 570                 575     


Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly 
            580                 585                 590         


Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu 
        595                 600                 605             


Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg 
    610                 615                 620                 


Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg 
625                 630                 635                 640 


Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly 
                645                 650                 655     


Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro 
            660                 665                 670         


Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr 
        675                 680                 685             


His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile 
    690                 695                 700                 


Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg 
705                 710                 715                 720 


Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn 
                725                 730                 735     


Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu 
            740                 745                 750         


Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr 
        755                 760                 765             


Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala 
    770                 775                 780                 


Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  716
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  716

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Pro 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  717
<211>  977
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  717

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Arg 
                325                 330                 335     


Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys 
            340                 345                 350         


Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu 
        355                 360                 365             


Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu 
    370                 375                 380                 


Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp 
385                 390                 395                 400 


Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val 
                405                 410                 415     


Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser 
            420                 425                 430         


Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser 
        435                 440                 445             


Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile 
    450                 455                 460                 


Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu 
465                 470                 475                 480 


Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile 
                485                 490                 495     


Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr 
            500                 505                 510         


Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu 
        515                 520                 525             


Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys 
    530                 535                 540                 


Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn 
545                 550                 555                 560 


Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp 
                565                 570                 575     


Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly 
            580                 585                 590         


Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu 
        595                 600                 605             


Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg 
    610                 615                 620                 


Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg 
625                 630                 635                 640 


Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly 
                645                 650                 655     


Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro 
            660                 665                 670         


Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr 
        675                 680                 685             


His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile 
    690                 695                 700                 


Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg 
705                 710                 715                 720 


Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn 
                725                 730                 735     


Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu 
            740                 745                 750         


Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr 
        755                 760                 765             


Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala 
    770                 775                 780                 


Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  718
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  718

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Leu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  719
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  719

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Arg 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  720
<211>  979
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  720

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  721
<211>  979
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  721

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn His Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  722
<211>  979
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  722

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Ala Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  723
<211>  979
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  723

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  724
<211>  979
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  724

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Pro Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  725
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  725

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Thr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  726
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  726

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Met 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  727
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  727

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Asn His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  728
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  728

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Trp His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  729
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  729

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Tyr Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  730
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  730

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Pro Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  731
<211>  979
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  731

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Glu Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  732
<211>  979
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  732

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Arg Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  733
<211>  979
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  733

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Trp Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  734
<211>  979
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  734

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Tyr Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  735
<211>  979
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  735

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Tyr Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  736
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  736

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Arg Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  737
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  737

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Asp 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  738
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  738

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Pro 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  739
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  739

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Leu Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  740
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  740

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Gly Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  741
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  741

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Gln Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  742
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  742

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Asp Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  743
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  743

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Thr Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  744
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  744

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Thr Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  745
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  745

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Lys Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  746
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  746

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Glu Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  747
<211>  979
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  747

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Ser Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  748
<211>  979
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  748

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Arg Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  749
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  749

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Lys Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  750
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  750

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Ser Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  751
<211>  979
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  751

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  752
<211>  979
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  752

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Gln Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  753
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  753

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Lys Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  754
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  754

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Asp Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  755
<211>  979
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  755

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Val 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  756
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  756

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Asp 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  757
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  757

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Arg Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  758
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  758

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys His Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  759
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  759

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Pro Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  760
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  760

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Thr Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  761
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  761

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Phe 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  762
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  762

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Val 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  763
<211>  979
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  763

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  764
<211>  979
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  764

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Thr Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  765
<211>  979
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  765

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Asn Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  766
<211>  979
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  766

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Arg Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  767
<211>  979
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  767

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Ser Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  768
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  768

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Trp Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  769
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  769

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Arg Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  770
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  770

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ser Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  771
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  771

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val His 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  772
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  772

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Ser Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  773
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  773

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Ala Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  774
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  774

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Asp Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  775
<211>  979
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  775

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Asn Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  776
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  776

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Val Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  777
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  777

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Ile Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  778
<211>  977
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  778

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asn Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  779
<211>  977
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  779

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Ser Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  780
<211>  977
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  780

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Ser Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Leu Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  781
<211>  977
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  781

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asn Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  782
<211>  977
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  782

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Pro Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  783
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  783

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Asp Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  784
<211>  979
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  784

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys His Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  785
<211>  979
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  785

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  786
<211>  979
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  786

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Arg Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Ser 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  787
<211>  979
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  787

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Arg Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Gly Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  788
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  788

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asn Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  789
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  789

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Lys Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Ser Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  790
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  790

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Ser Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Gly Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  791
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  791

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Lys Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Ser Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Gly Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  792
<211>  979
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  792

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Arg Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Lys Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  793
<211>  979
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  793

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Arg Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Lys Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Ser 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  794
<211>  979
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  794

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Arg Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Lys Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Ser 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Gly Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  795
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  795

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Tyr Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Gly Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  796
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  796

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser His Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Gly Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  797
<211>  979
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  797

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Arg Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Tyr 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Gly Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  798
<211>  979
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  798

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Arg Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser His 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Gly Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  799
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  799

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Lys Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Gly Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  800
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  800

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Lys Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Tyr Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Gly Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  801
<211>  979
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  801

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Arg Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Lys Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Gly Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  802
<211>  979
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  802

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Arg Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Lys Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Tyr 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Gly Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  803
<211>  979
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  803

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Arg Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Lys Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser His 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Gly Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  804
<211>  979
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  804

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Arg Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Tyr 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  805
<211>  979
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  805

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Arg Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser His 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  806
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  806

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Lys Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  807
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  807

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Lys Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Tyr Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  808
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  808

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Lys Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser His Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  809
<211>  979
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  809

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Arg Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Lys Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Tyr 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  810
<211>  979
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  810

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Arg Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Lys Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser His 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  811
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  811

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Lys Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser His Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Gly Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  812
<211>  979
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  812

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Ala 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  813
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  813

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Val Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  814
<211>  979
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  814

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Gly Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  815
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  815

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu His Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  816
<211>  979
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  816

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Cys Ala Gly Asn Arg Tyr Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  817
<211>  976
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  817

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Val Cys Asn Val Lys Lys Leu 
            340                 345                 350         


Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu Ala 
        355                 360                 365             


Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu Glu 
    370                 375                 380                 


Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp Leu 
385                 390                 395                 400 


Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val Tyr 
                405                 410                 415     


Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser Lys 
            420                 425                 430         


His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser Lys 
        435                 440                 445             


Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile Glu 
    450                 455                 460                 


Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu Lys 
465                 470                 475                 480 


Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile Glu 
                485                 490                 495     


Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn 
            500                 505                 510         


Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr 
        515                 520                 525             


Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile 
    530                 535                 540                 


Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys 
545                 550                 555                 560 


Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp 
                565                 570                 575     


Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg 
            580                 585                 590         


Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys 
        595                 600                 605             


Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr 
    610                 615                 620                 


Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg 
625                 630                 635                 640 


Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Val 
                645                 650                 655     


Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu 
            660                 665                 670         


Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His 
        675                 680                 685             


Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln 
    690                 695                 700                 


Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys 
705                 710                 715                 720 


Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr 
                725                 730                 735     


Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile 
            740                 745                 750         


Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe 
        755                 760                 765             


Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys 
    770                 775                 780                 


Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys Thr Leu 
785                 790                 795                 800 


Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr 
                805                 810                 815     


Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr 
            820                 825                 830         


Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln 
        835                 840                 845             


Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu 
    850                 855                 860                 


Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile 
865                 870                 875                 880 


Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys 
                885                 890                 895     


Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn 
            900                 905                 910         


Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala 
        915                 920                 925             


Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr 
    930                 935                 940                 


Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp 
945                 950                 955                 960 


Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
                965                 970                 975     


<210>  818
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  818

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Gly Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  819
<211>  979
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  819

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Leu Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  820
<211>  979
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  820

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Gln Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  821
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  821

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Ser Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  822
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  822

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Glu Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  823
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  823

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Thr Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  824
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  824

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Asn Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  825
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  825

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Leu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  826
<211>  976
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  826

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Arg Cys Glu Leu Lys 
465                 470                 475                 480 


Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile Glu 
                485                 490                 495     


Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn 
            500                 505                 510         


Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr 
        515                 520                 525             


Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile 
    530                 535                 540                 


Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys 
545                 550                 555                 560 


Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp 
                565                 570                 575     


Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg 
            580                 585                 590         


Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys 
        595                 600                 605             


Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr 
    610                 615                 620                 


Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg 
625                 630                 635                 640 


Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Val 
                645                 650                 655     


Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu 
            660                 665                 670         


Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His 
        675                 680                 685             


Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln 
    690                 695                 700                 


Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys 
705                 710                 715                 720 


Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr 
                725                 730                 735     


Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile 
            740                 745                 750         


Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe 
        755                 760                 765             


Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys 
    770                 775                 780                 


Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys Thr Leu 
785                 790                 795                 800 


Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr 
                805                 810                 815     


Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr 
            820                 825                 830         


Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln 
        835                 840                 845             


Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu 
    850                 855                 860                 


Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile 
865                 870                 875                 880 


Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys 
                885                 890                 895     


Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn 
            900                 905                 910         


Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala 
        915                 920                 925             


Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr 
    930                 935                 940                 


Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp 
945                 950                 955                 960 


Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
                965                 970                 975     


<210>  827
<211>  976
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  827

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Ala Leu Arg Pro Tyr Leu Ser Ser Glu Glu 
    370                 375                 380                 


Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp Leu 
385                 390                 395                 400 


Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val Tyr 
                405                 410                 415     


Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser Lys 
            420                 425                 430         


His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser Lys 
        435                 440                 445             


Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile Glu 
    450                 455                 460                 


Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu Lys 
465                 470                 475                 480 


Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile Glu 
                485                 490                 495     


Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn 
            500                 505                 510         


Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr 
        515                 520                 525             


Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile 
    530                 535                 540                 


Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys 
545                 550                 555                 560 


Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp 
                565                 570                 575     


Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg 
            580                 585                 590         


Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys 
        595                 600                 605             


Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr 
    610                 615                 620                 


Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg 
625                 630                 635                 640 


Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Val 
                645                 650                 655     


Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu 
            660                 665                 670         


Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His 
        675                 680                 685             


Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln 
    690                 695                 700                 


Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys 
705                 710                 715                 720 


Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr 
                725                 730                 735     


Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile 
            740                 745                 750         


Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe 
        755                 760                 765             


Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys 
    770                 775                 780                 


Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys Thr Leu 
785                 790                 795                 800 


Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr 
                805                 810                 815     


Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr 
            820                 825                 830         


Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln 
        835                 840                 845             


Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu 
    850                 855                 860                 


Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile 
865                 870                 875                 880 


Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys 
                885                 890                 895     


Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn 
            900                 905                 910         


Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala 
        915                 920                 925             


Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr 
    930                 935                 940                 


Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp 
945                 950                 955                 960 


Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
                965                 970                 975     


<210>  828
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  828

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Gln Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  829
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  829

Gln Glu Ile Lys Arg Leu Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  830
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  830

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Asp Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  831
<211>  976
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  831

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn 
            500                 505                 510         


Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr 
        515                 520                 525             


Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile 
    530                 535                 540                 


Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys 
545                 550                 555                 560 


Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp 
                565                 570                 575     


Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg 
            580                 585                 590         


Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys 
        595                 600                 605             


Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr 
    610                 615                 620                 


Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg 
625                 630                 635                 640 


Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Val 
                645                 650                 655     


Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu 
            660                 665                 670         


Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His 
        675                 680                 685             


Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln 
    690                 695                 700                 


Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys 
705                 710                 715                 720 


Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr 
                725                 730                 735     


Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile 
            740                 745                 750         


Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe 
        755                 760                 765             


Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys 
    770                 775                 780                 


Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys Thr Leu 
785                 790                 795                 800 


Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr 
                805                 810                 815     


Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr 
            820                 825                 830         


Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln 
        835                 840                 845             


Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu 
    850                 855                 860                 


Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile 
865                 870                 875                 880 


Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys 
                885                 890                 895     


Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn 
            900                 905                 910         


Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala 
        915                 920                 925             


Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr 
    930                 935                 940                 


Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp 
945                 950                 955                 960 


Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
                965                 970                 975     


<210>  832
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  832

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Val Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  833
<211>  979
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  833

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Gly Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  834
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  834

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Phe Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  835
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  835

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Tyr Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  836
<211>  979
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  836

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Pro Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  837
<211>  979
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  837

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Thr Ile Ala Gly Asn Arg Tyr Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  838
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  838

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Cys Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  839
<211>  979
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  839

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Pro 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  840
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  840

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Gly Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  841
<211>  977
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  841

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  842
<211>  979
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  842

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ile Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  843
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  843

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Lys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  844
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  844

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Gln Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  845
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  845

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Tyr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  846
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  846

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Lys Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  847
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  847

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ala Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  848
<211>  979
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  848

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  849
<211>  977
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  849

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  850
<211>  979
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  850

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Trp Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  851
<211>  979
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  851

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


His Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  852
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  852

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Pro Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  853
<211>  979
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  853

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  854
<211>  979
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  854

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  855
<211>  979
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  855

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Phe Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  856
<211>  979
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  856

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Asn Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  857
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  857

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Pro Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  858
<211>  979
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  858

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Trp Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  859
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  859

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Met Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  860
<211>  977
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  860

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  861
<211>  979
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  861

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Val Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  862
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  862

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Pro Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  863
<211>  979
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  863

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Pro Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  864
<211>  979
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  864

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Met Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  865
<211>  979
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  865

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Arg Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  866
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  866

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Phe Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  867
<211>  977
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  867

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  868
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  868

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Gln Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  869
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  869

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Asn Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  870
<211>  979
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  870

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu His Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  871
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  871

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Val Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  872
<211>  979
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  872

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Gln Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  873
<211>  979
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  873

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Pro Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  874
<211>  979
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  874

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Arg Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  875
<211>  979
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  875

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Trp Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  876
<211>  979
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  876

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Asn Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  877
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  877

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Ser Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  878
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  878

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ser Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  879
<211>  979
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  879

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Arg Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  880
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  880

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Arg Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  881
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  881

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Asp Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  882
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  882

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Gln Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  883
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  883

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Met Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  884
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  884

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Ile Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  885
<211>  979
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  885

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Val Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  886
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  886

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Glu Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  887
<211>  979
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  887

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Met Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  888
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  888

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Gln Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  889
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  889

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Ile Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  890
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  890

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Asn Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  891
<211>  979
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  891

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Gly Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  892
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  892

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Met Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  893
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  893

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Gln Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  894
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  894

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Glu Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  895
<211>  979
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  895

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Ser Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  896
<211>  979
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  896

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Lys Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  897
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  897

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gly Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  898
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  898

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ile Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  899
<211>  979
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  899

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Leu Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  900
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  900

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Asp Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  901
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  901

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe His Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  902
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  902

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Glu Gln Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  903
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  903

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Pro Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  904
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  904

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Asp Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  905
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  905

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Glu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  906
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  906

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Pro Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  907
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  907

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Pro Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  908
<211>  977
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  908

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Pro Val 
    210                 215                 220                 


Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu 
225                 230                 235                 240 


Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys Gly 
                245                 250                 255     


Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn 
            260                 265                 270         


Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu 
        275                 280                 285             


Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp Val 
    290                 295                 300                 


Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys 
305                 310                 315                 320 


Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg 
                325                 330                 335     


Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys 
            340                 345                 350         


Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu 
        355                 360                 365             


Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu 
    370                 375                 380                 


Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp 
385                 390                 395                 400 


Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val 
                405                 410                 415     


Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser 
            420                 425                 430         


Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser 
        435                 440                 445             


Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile 
    450                 455                 460                 


Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu 
465                 470                 475                 480 


Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile 
                485                 490                 495     


Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr 
            500                 505                 510         


Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu 
        515                 520                 525             


Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys 
    530                 535                 540                 


Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn 
545                 550                 555                 560 


Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp 
                565                 570                 575     


Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly 
            580                 585                 590         


Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu 
        595                 600                 605             


Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg 
    610                 615                 620                 


Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg 
625                 630                 635                 640 


Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly 
                645                 650                 655     


Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro 
            660                 665                 670         


Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr 
        675                 680                 685             


His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile 
    690                 695                 700                 


Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg 
705                 710                 715                 720 


Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn 
                725                 730                 735     


Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu 
            740                 745                 750         


Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr 
        755                 760                 765             


Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala 
    770                 775                 780                 


Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  909
<211>  977
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  909

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val Ser 
    130                 135                 140                 


Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val Ala 
145                 150                 155                 160 


Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys Asp 
                165                 170                 175     


Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala 
            180                 185                 190         


Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro Val 
        195                 200                 205             


Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val 
    210                 215                 220                 


Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu 
225                 230                 235                 240 


Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys Gly 
                245                 250                 255     


Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn 
            260                 265                 270         


Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu 
        275                 280                 285             


Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp Val 
    290                 295                 300                 


Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys 
305                 310                 315                 320 


Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg 
                325                 330                 335     


Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys 
            340                 345                 350         


Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu 
        355                 360                 365             


Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu 
    370                 375                 380                 


Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp 
385                 390                 395                 400 


Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val 
                405                 410                 415     


Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser 
            420                 425                 430         


Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser 
        435                 440                 445             


Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile 
    450                 455                 460                 


Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu 
465                 470                 475                 480 


Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile 
                485                 490                 495     


Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr 
            500                 505                 510         


Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu 
        515                 520                 525             


Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys 
    530                 535                 540                 


Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn 
545                 550                 555                 560 


Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp 
                565                 570                 575     


Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly 
            580                 585                 590         


Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu 
        595                 600                 605             


Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg 
    610                 615                 620                 


Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg 
625                 630                 635                 640 


Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly 
                645                 650                 655     


Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro 
            660                 665                 670         


Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr 
        675                 680                 685             


His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile 
    690                 695                 700                 


Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg 
705                 710                 715                 720 


Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn 
                725                 730                 735     


Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu 
            740                 745                 750         


Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr 
        755                 760                 765             


Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala 
    770                 775                 780                 


Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  910
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  910

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr His Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  911
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  911

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala His Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  912
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  912

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Thr Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  913
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  913

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Asp 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  914
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  914

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Glu 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  915
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  915

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Arg Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  916
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  916

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Lys Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  917
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  917

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Lys Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  918
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  918

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Arg Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  919
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  919

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Lys Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  920
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  920

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Arg Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  921
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  921

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Lys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  922
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  922

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Arg Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  923
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  923

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Lys Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  924
<211>  977
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  924

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr 
            500                 505                 510         


Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu 
        515                 520                 525             


Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys 
    530                 535                 540                 


Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn 
545                 550                 555                 560 


Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp 
                565                 570                 575     


Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly 
            580                 585                 590         


Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu 
        595                 600                 605             


Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg 
    610                 615                 620                 


Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg 
625                 630                 635                 640 


Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly 
                645                 650                 655     


Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro 
            660                 665                 670         


Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr 
        675                 680                 685             


His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile 
    690                 695                 700                 


Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg 
705                 710                 715                 720 


Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn 
                725                 730                 735     


Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu 
            740                 745                 750         


Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr 
        755                 760                 765             


Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala 
    770                 775                 780                 


Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  925
<211>  977
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  925

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Asp Ile Ser Gly Phe Ser Lys Gln Tyr 
            500                 505                 510         


Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu 
        515                 520                 525             


Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys 
    530                 535                 540                 


Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn 
545                 550                 555                 560 


Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp 
                565                 570                 575     


Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly 
            580                 585                 590         


Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu 
        595                 600                 605             


Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg 
    610                 615                 620                 


Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg 
625                 630                 635                 640 


Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly 
                645                 650                 655     


Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro 
            660                 665                 670         


Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr 
        675                 680                 685             


His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile 
    690                 695                 700                 


Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg 
705                 710                 715                 720 


Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn 
                725                 730                 735     


Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu 
            740                 745                 750         


Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr 
        755                 760                 765             


Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala 
    770                 775                 780                 


Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  926
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  926

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Arg Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  927
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  927

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Lys Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  928
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  928

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Gln Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  929
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  929

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Gln Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  930
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  930

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Thr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  931
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  931

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Gln Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  932
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  932

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gln Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  933
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  933

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Ala Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  934
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  934

Gln Glu Ile Lys Pro Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  935
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  935

Gln Glu Ile Trp Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  936
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  936

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Pro Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  937
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  937

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Ala Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  938
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  938

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Leu Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  939
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  939

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met His Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  940
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  940

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Thr Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  941
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  941

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Glu Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  942
<211>  977
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  942

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp 
                565                 570                 575     


Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly 
            580                 585                 590         


Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu 
        595                 600                 605             


Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg 
    610                 615                 620                 


Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg 
625                 630                 635                 640 


Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly 
                645                 650                 655     


Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro 
            660                 665                 670         


Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr 
        675                 680                 685             


His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile 
    690                 695                 700                 


Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg 
705                 710                 715                 720 


Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn 
                725                 730                 735     


Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu 
            740                 745                 750         


Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr 
        755                 760                 765             


Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala 
    770                 775                 780                 


Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  943
<211>  979
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  943

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Ala Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  944
<211>  978
<212>  PRT
<213>  ArtSeq 	CasX Variant

<400>  944

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Lys Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  945
<211>  89
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  945
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  946
<211>  97
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  946
acuggcgccu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagaagc aucaaag                                97


<210>  947
<211>  89
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  947
gcuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  948
<211>  88
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  948
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcucccucu ucggagggag caucaaag                                          88


<210>  949
<211>  151
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  949
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aauaggagcu gcacuauggg cgcaguguca uugacgcuga cgguacaggc cagacaauua      120

uugucuggua uagugcagcu ccuaaucaaa g                                     151


<210>  950
<211>  97
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  950
acuggcgccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagaagc aucaaag                                97


<210>  951
<211>  97
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  951
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagaagc aucaaag                                97


<210>  952
<211>  98
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  952
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcgcuuac ggacuucggu ccguaagaag caucaaag                               98


<210>  953
<211>  89
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  953
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  954
<211>  98
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  954
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauugggua       60

aagcgcuuac ggacuucggu ccguaagaag caucaaag                               98


<210>  955
<211>  98
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  955
acuggcgccu uuaucaucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuac ggacuucggu ccguaagaag caucaaag                               98


<210>  956
<211>  90
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  956
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcgcccuc uucggaggga agcaucaaag                                        90


<210>  957
<211>  96
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  957
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucacau gaggaucacc caugugagca ucaaag                                 96


<210>  958
<211>  89
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  958
acuggcacuu uuaccugauu acuuugagag ccaacaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  959
<211>  89
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  959
acuggcacuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  960
<211>  89
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  960
acuggcccuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  961
<211>  89
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  961
acuggcgcuu uuaccugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  962
<211>  89
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  962
acuggcgcuu uuaucugauu acuuugagag ccaacaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  963
<211>  97
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  963
acuggcaccu uuaccugauu acuuugagag ccaacaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagaagc aucaaag                                97


<210>  964
<211>  97
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  964
acuggcaccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagaagc aucaaag                                97


<210>  965
<211>  97
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  965
acuggccccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagaagc aucaaag                                97


<210>  966
<211>  97
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  966
acuggcgccu uuaucugauu acuuugagag ccaacaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagaagc aucaaag                                97


<210>  967
<211>  89
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  967
gcuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  968
<211>  90
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  968
gacuggcgcu uuuaucugau uacuuugaga gccaucacca gcgacuaugu cguagugggu       60

aaagcucccu cuucggaggg agcaucaaag                                        90


<210>  969
<211>  90
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  969
acuggcgccu uuaucugauu acuuuggaga gccaucacca gcgacuaugu cguagugggu       60

aaagcucccu cuucggaggg agcaucaaag                                        90


<210>  970
<211>  89
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  970
acuggcgcau uuaucugauu acuuugugag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  971
<211>  89
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  971
acuggcgccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  972
<211>  90
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  972
acuggcgcuu uuaucugauu acuuuggaga gccaucacca gcgacuaugu cguagugggu       60

aaagcucccu cuucggaggg agcaucaaag                                        90


<210>  973
<211>  89
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  973
acuggcgcau uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  974
<211>  89
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  974
acuggcgcuu uuaucugauu acuuugugag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  975
<211>  90
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  975
acuggcgcuu uuauucugau uacuuugaga gccaucacca gcgacuaugu cguagugggu       60

aaagcucccu cuucggaggg agcaucaaag                                        90


<210>  976
<211>  88
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  976
acggcgcuuu uaucugauua cuuugagagc caucaccagc gacuaugucg uaguggguaa       60

agcucccucu ucggagggag caucaaag                                          88


<210>  977
<211>  89
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  977
acuggcgcuu uuauaugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  978
<211>  90
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  978
acuggcgcuu uuaucuugau uacuuugaga gccaucacca gcgacuaugu cguagugggu       60

aaagcucccu cuucggaggg agcaucaaag                                        90


<210>  979
<211>  89
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  979
acuggcgcuu uuaucugauu acuuugagag ccagcaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  980
<211>  89
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  980
acuggcgcug uuaucugauu acuucgagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucgaag                                         89


<210>  981
<211>  89
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  981
acuggcgcuc uuaucugauu acuucgagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucgaag                                         89


<210>  982
<211>  89
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  982
acuggcgcuu guaucugauu acucugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucagag                                         89


<210>  983
<211>  89
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  983
acuggcgcuu cuaucugauu acucugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucagag                                         89


<210>  984
<211>  89
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  984
acuggcgcuu ugaucugauu accuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaagg                                         89


<210>  985
<211>  89
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  985
acuggcgcuu ucaucugauu accuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaagg                                         89


<210>  986
<211>  89
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  986
acuggcgcug uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  987
<211>  89
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  987
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucgaag                                         89


<210>  988
<211>  89
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  988
acuggcgcuu uuaucugauu acuucgagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  989
<211>  98
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  989
acuggcacuu cuaucugauu acucugagag ccaucaccag cgacuauguc guauggguaa       60

agccgcuuac ggacuucggu ccguaagagg caucagag                               98


<210>  990
<211>  89
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  990
acuggcacuu cuaucugauu acucugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucagag                                         89


<210>  991
<211>  98
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  991
acuggcaccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agccgcuuac ggacuucggu ccguaagagg caucaaag                               98


<210>  992
<211>  98
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  992
acuggcacuu guaucugauu acucugagag ccaucaccag cgacuauguc guauggguaa       60

agccgcuuac ggacuucggu ccguaagagg caucagag                               98


<210>  993
<211>  89
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  993
acuggcacuu guaucugauu acucugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucagag                                         89


<210>  994
<211>  141
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  994
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag cgucaaugac gcugacggua caggccagac aauuauuguc      120

ugguauagug cagcaucaaa g                                                141


<210>  995
<211>  309
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  995
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcuaggag cuuuguuccu uggguucuug ggagcagcag gaagcacuau gggcgcagcg      120

ucaaugacgc ugacgguaca ggccagacaa uuauugucug guauagugca gcagcagaac      180

aauuugcuga gggcuauuga ggcgcaacag caucuguugc aacucacagu cuggggcauc      240

aagcagcucc aggcaagaau ccuggcugug gaaagauacc uaaaggauca acagcuccua      300

gcaucaaag                                                              309


<210>  996
<211>  100
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  996
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcuccccg uacaccauca ggguacgggg agcaucaaag                            100


<210>  997
<211>  97
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  997
acuggcacuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagaagc aucaaag                                97


<210>  998
<211>  97
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  998
acuggcacuu cuaucugauu acucugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagaagc aucagag                                97


<210>  999
<211>  98
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  999
acuggcgcuu cuaucugauu acucugagag ccaucaccag cgacuauguc guauggguaa       60

agccgcuuac ggacuucggu ccguaagagg caucagag                               98


<210>  1000
<211>  98
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1000
acuggcacuu cuaucugauu acucugagcg ccaucaccag cgacuauguc guauggguaa       60

agccgcuuac ggacuucggu ccguaagagg caucagag                               98


<210>  1001
<211>  98
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1001
acuggcgcuu cuaucugauu acucugagcg ccaucaccag cgacuauguc guauggguaa       60

agccgcuuac ggacuucggu ccguaagagg caucagag                               98


<210>  1002
<211>  98
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1002
acuggcgcuu cuaucugauu acucugagcg ccaucaccag cgacuauguc guauggguaa       60

agcgccuuac ggacuucggu ccguaaggag caucagag                               98


<210>  1003
<211>  99
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1003
acuggcgcuu cuaucugauu acucugagcg ccaucaccag cgacuauguc guagugggua       60

aagccgcuua cggacuucgg uccguaagag gcaucagag                              99


<210>  1004
<211>  98
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1004
acgggacuuu cuaucugauu acucugaagu cccucaccag cgacuauguc guauggguaa       60

agccgcuuac ggacuucggu ccguaagagg caucagag                               98


<210>  1005
<211>  98
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1005
accuguaguu cuaucugauu acucugacua cagucaccag cgacuauguc guauggguaa       60

agccgcuuac ggacuucggu ccguaagagg caucagag                               98


<210>  1006
<211>  113
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1006
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacg gugggcgcag cuucggcuga cgguacaccg ugcagcauca aag             113


<210>  1007
<211>  143
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1007
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacg gugggcgcag cuucggcuga cgguacaccg gugggcgcag cuucggcuga      120

cgguacaccg ugcagcauca aag                                              143


<210>  1008
<211>  173
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1008
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacg gugggcgcag cuucggcuga cgguacaccg gugggcgcag cuucggcuga      120

cgguacaccg gugggcgcag cuucggcuga cgguacaccg ugcagcauca aag             173


<210>  1009
<211>  203
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1009
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacg gugggcgcag cuucggcuga cgguacaccg gugggcgcag cuucggcuga      120

cgguacaccg gugggcgcag cuucggcuga cgguacaccg gugggcgcag cuucggcuga      180

cgguacaccg ugcagcauca aag                                              203


<210>  1010
<211>  233
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1010
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacg gugggcgcag cuucggcuga cgguacaccg gugggcgcag cuucggcuga      120

cgguacaccg gugggcgcag cuucggcuga cgguacaccg gugggcgcag cuucggcuga      180

cgguacaccg gugggcgcag cuucggcuga cgguacaccg ugcagcauca aag             233


<210>  1011
<211>  97
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1011
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacc uagcggaggc uaggugcagc aucaaag                                97


<210>  1012
<211>  118
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1012
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacc ucggcuugcu gaagcgcgca cggcaagagg cgaggugcag caucaaag        118


<210>  1013
<211>  192
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1013
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacc ucucucgacg caggacucgg cuugcugaag cgcgcacggc aagaggcgag      120

gggcggcgac uggugaguac gccaaaaauu uugacuagcg gaggcuagaa ggagagaggu      180

gcagcaucaa ag                                                          192


<210>  1014
<211>  156
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1014
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacg gugcccgucu guugugucga gagacgccaa aaauuuugac uagcggaggc      120

uagaaggaga gagaugggug ccgugcagca ucaaag                                156


<210>  1015
<211>  96
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1015
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcaca uggagaggag augugcagca ucaaag                                 96


<210>  1016
<211>  91
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1016
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcaca uggagaugug cagcaucaaa g                                      91


<210>  1017
<211>  106
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1017
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcuugggc gcagcgucaa ugacgcugac gguacaagca ucaaag                     106


<210>  1018
<211>  145
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1018
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag cgucaaugac gcugacggua caggccacau gaggaucacc      120

caugugguau agugcagcau caaag                                            145


<210>  1019
<211>  155
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1019
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag cucaugagga ucacccauga gcugacggua caggccacau      120

gaggaucacc caugugguau agugcagcau caaag                                 155


<210>  1020
<211>  151
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1020
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag cgucaaugac gcugacggua caggccacau ggcagucgua      120

acgacgcggg ugguauagug cagcaucaaa g                                     151


<210>  1021
<211>  172
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1021
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag caaacauggc aguccuaagg acgcggguuu ugcugacggu      120

acaggccaca uggcagucgu aacgacgcgg gugguauagu gcagcaucaa ag              172


<210>  1022
<211>  159
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1022
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag acauggcagu cguaacgacg cgggucugac gguacaggcc      120

acaugaggau cacccaugug guauagugca gcaucaaag                             159


<210>  1023
<211>  108
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1023
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu aaggaguuua uauggaaacc cuuagugcag caucaaag                   108


<210>  1024
<211>  242
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1024
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucagga agcacuaugg gcgcagcguc aaugacgcug acgguacagg ccagacaauu      120

auugucuggu auagugcagc agcagaacaa uuugcugagg gcuauugagg cgcaacagca      180

ucuguugcaa cucacagucu ggggcaucaa gcagcuccag gcaagaaucc ugagcaucaa      240

ag                                                                     242


<210>  1025
<211>  98
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1025
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacg cccugaagaa gggcgugcag caucaaag                               98


<210>  1026
<211>  111
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1026
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacg gcucguguag cucauuagcu ccgagccgug cagcaucaaa g               111


<210>  1027
<211>  113
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1027
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacc cgugugcauc cgcagugucg gauccacggg ugcagcauca aag             113


<210>  1028
<211>  112
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1028
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacg gaauccauug cacuccggau uucacuaggu gcagcaucaa ag              112


<210>  1029
<211>  103
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1029
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcaca ugcaugucua agacagcaug ugcagcauca aag                        103


<210>  1030
<211>  106
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1030
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcaca aaacauaagg aaaaccuaug uugugcagca ucaaag                     106


<210>  1031
<211>  153
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1031
acuggcgcuu cuaucugauu acucugagcg ccaucaccag cgacuauguc guagugggua       60

aagccgcuua cggacuaugg gcgcagcguc aaugacgcug acgguacagg ccagacaauu      120

auugucuggu auaguccgua agaggcauca gag                                   153


<210>  1032
<211>  147
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1032
acuggcgcuu cuaucugauu acucugagcg ccaucaccag cgacuauguc guagugggua       60

aagccgcuua cgggugggcg cagcgucaau gacgcugacg guacaggcca gacaauuauu      120

gucugguacc cguaagaggc aucagag                                          147


<210>  1033
<211>  157
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1033
acuggcgcuu cuaucugauu acucugagcg ccaucaccag cgacuauguc guagugggua       60

aagccgcuua cggacuaugg gcgcagcguc aaugacgcug acgguacagg ccacaugagg      120

aucacccaug ugguauaguc cguaagaggc aucagag                               157


<210>  1034
<211>  143
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1034
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccua ugggcgcagc gucaaugacg cugacgguac aggccacaug aggaucaccc      120

augugguaua gggagcauca aag                                              143


<210>  1035
<211>  167
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1035
acuggcgcuu cuaucugauu acucugagcg ccaucaccag cgacuauguc guagugggua       60

aagccgcuua cggacuaugg gcgcagcuca ugaggaucac ccaugagcug acgguacagg      120

ccacaugagg aucacccaug ugguauaguc cguaagaggc aucagag                    167


<210>  1036
<211>  153
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1036
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccua ugggcgcagc ucaugaggau cacccaugag cugacgguac aggccacaug      120

aggaucaccc augugguaua gggagcauca aag                                   153


<210>  1037
<211>  163
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1037
acuggcgcuu cuaucugauu acucugagcg ccaucaccag cgacuauguc guagugggua       60

aagccgcuua cggacuaugg gcgcagcguc aaugacgcug acgguacagg ccacauggca      120

gucguaacga cgcggguggu auaguccgua agaggcauca gag                        163


<210>  1038
<211>  149
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1038
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccua ugggcgcagc gucaaugacg cugacgguac aggccacaug gcagucguaa      120

cgacgcgggu gguauaggga gcaucaaag                                        149


<210>  1039
<211>  184
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1039
acuggcgcuu cuaucugauu acucugagcg ccaucaccag cgacuauguc guagugggua       60

aagccgcuua cggacuaugg gcgcagcaaa cauggcaguc cuaaggacgc ggguuuugcu      120

gacgguacag gccacauggc agucguaacg acgcgggugg uauaguccgu aagaggcauc      180

agag                                                                   184


<210>  1040
<211>  170
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1040
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccua ugggcgcagc aaacauggca guccuaagga cgcggguuuu gcugacggua      120

caggccacau ggcagucgua acgacgcggg ugguauaggg agcaucaaag                 170


<210>  1041
<211>  171
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1041
acuggcgcuu cuaucugauu acucugagcg ccaucaccag cgacuauguc guagugggua       60

aagccgcuua cggacuaugg gcgcagacau ggcagucgua acgacgcggg ucugacggua      120

caggccacau gaggaucacc caugugguau aguccguaag aggcaucaga g               171


<210>  1042
<211>  157
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1042
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccua ugggcgcaga cauggcaguc guaacgacgc gggucugacg guacaggcca      120

caugaggauc acccaugugg uauagggagc aucaaag                               157


<210>  1043
<211>  155
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1043
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag caccugagga ucacccaggu gcugacggua caggccaccu      120

gaggaucacc caggugguau agugcagcau caaag                                 155


<210>  1044
<211>  155
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1044
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag cgcaugagga ucacccaugc gcugacggua caggccgcau      120

gaggaucacc caugcgguau agugcagcau caaag                                 155


<210>  1045
<211>  155
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1045
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag cgccugagga ucacccaggc gcugacggua caggccgccu      120

gaggaucacc caggcgguau agugcagcau caaag                                 155


<210>  1046
<211>  155
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1046
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag cgccugagca ucagccaggc gcugacggua caggccgccu      120

gagcaucagc caggcgguau agugcagcau caaag                                 155


<210>  1047
<211>  155
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1047
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag cacaugagca ucagccaugu gcugacggua caggccacau      120

gagcaucagc caugugguau agugcagcau caaag                                 155


<210>  1048
<211>  155
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1048
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag cacaugagua ucaaccaugu gcugacggua caggccacau      120

gaguaucaac caugugguau agugcagcau caaag                                 155


<210>  1049
<211>  155
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1049
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag cacaugagaa ucagccaugu gcugacggua caggccacau      120

gagaaucagc caugugguau agugcagcau caaag                                 155


<210>  1050
<211>  155
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1050
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag cccuugagga ucacccaugu gcugacggua caggccccuu      120

gaggaucacc caugugguau agugcagcau caaag                                 155


<210>  1051
<211>  155
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1051
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag cacuugagga ucacccaugu gcugacggua caggccacuu      120

gaggaucacc caugugguau agugcagcau caaag                                 155


<210>  1052
<211>  155
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1052
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag caccugagga ucacccaugu gcugacggua caggccaccu      120

gaggaucacc caugugguau agugcagcau caaag                                 155


<210>  1053
<211>  155
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1053
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag cacaugagga ucaccuaugu gcugacggua caggccacau      120

gaggaucacc uaugugguau agugcagcau caaag                                 155


<210>  1054
<211>  155
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1054
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag cacauuagga ucaccaaugu gcugacggua caggccacau      120

uaggaucacc aaugugguau agugcagcau caaag                                 155


<210>  1055
<211>  155
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1055
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag cacauuagga ucaccgaugu gcugacggua caggccacau      120

uaggaucacc gaugugguau agugcagcau caaag                                 155


<210>  1056
<211>  155
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1056
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag cacauuagga ucaccuaugu gcugacggua caggccacau      120

uaggaucacc uaugugguau agugcagcau caaag                                 155


<210>  1057
<211>  155
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1057
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag cacaugagga uuacccaugu gcugacggua caggccacau      120

gaggauuacc caugugguau agugcagcau caaag                                 155


<210>  1058
<211>  155
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1058
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag cacaugagga uaacccaugu gcugacggua caggccacau      120

gaggauaacc caugugguau agugcagcau caaag                                 155


<210>  1059
<211>  155
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1059
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag cacaugagga ugacccaugu gcugacggua caggccacau      120

gaggaugacc caugugguau agugcagcau caaag                                 155


<210>  1060
<211>  155
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1060
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag cacaugagga ccacccaugu gcugacggua caggccacau      120

gaggaccacc caugugguau agugcagcau caaag                                 155


<210>  1061
<211>  155
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1061
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag cagaugagga ucacccaugg gcugacggua caggccagau      120

gaggaucacc caugggguau agugcagcau caaag                                 155


<210>  1062
<211>  155
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1062
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag cacaugggga ucacccaugu gcugacggua caggccacau      120

ggggaucacc caugugguau agugcagcau caaag                                 155


<210>  1063
<211>  155
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1063
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag cacaugagga ucacccaugu gcugacggua caggccacau      120

gaggaucacc caugugguau agugcagcau caaag                                 155


<210>  1064
<211>  96
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1064
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucaccu gaggaucacc caggugagca ucaaag                                 96


<210>  1065
<211>  96
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1065
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucgcau gaggaucacc caugcgagca ucaaag                                 96


<210>  1066
<211>  96
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1066
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucgccu gaggaucacc caggcgagca ucaaag                                 96


<210>  1067
<211>  96
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1067
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucgccu gagcaucagc caggcgagca ucaaag                                 96


<210>  1068
<211>  96
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1068
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucacau gagcaucagc caugugagca ucaaag                                 96


<210>  1069
<211>  96
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1069
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucacau gaguaucaac caugugagca ucaaag                                 96


<210>  1070
<211>  96
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1070
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucacau gagaaucagc caugugagca ucaaag                                 96


<210>  1071
<211>  96
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1071
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuu gaggaucacc caugugagca ucaaag                                 96


<210>  1072
<211>  96
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1072
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucacuu gaggaucacc caugugagca ucaaag                                 96


<210>  1073
<211>  96
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1073
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucaccu gaggaucacc caugugagca ucaaag                                 96


<210>  1074
<211>  96
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1074
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucacau gaggaucacc uaugugagca ucaaag                                 96


<210>  1075
<211>  96
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1075
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucacau uaggaucacc aaugugagca ucaaag                                 96


<210>  1076
<211>  96
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1076
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucacau uaggaucacc gaugugagca ucaaag                                 96


<210>  1077
<211>  96
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1077
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucacau uaggaucacc uaugugagca ucaaag                                 96


<210>  1078
<211>  96
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1078
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucacau gaggauuacc caugugagca ucaaag                                 96


<210>  1079
<211>  96
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1079
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucacau gaggauaacc caugugagca ucaaag                                 96


<210>  1080
<211>  96
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1080
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucacau gaggaugacc caugugagca ucaaag                                 96


<210>  1081
<211>  96
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1081
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucacau gaggaccacc caugugagca ucaaag                                 96


<210>  1082
<211>  96
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1082
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucagau gaggaucacc caugggagca ucaaag                                 96


<210>  1083
<211>  96
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1083
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucacau ggggaucacc caugugagca ucaaag                                 96


<210>  1084
<211>  96
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1084
acuggcgcuu cuaucugauu acucugagcg ccaucaccag cgacuauguc guagugggua       60

aagcucacau gaggaucacc caugugagca ucagag                                 96


<210>  1085
<211>  145
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1085
acuggcgcuu cuaucugauu acucugagcg ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag cgucaaugac gcugacggua caggccacau gaggaucacc      120

caugugguau agugcagcau cagag                                            145


<210>  1086
<211>  155
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1086
acuggcgcuu cuaucugauu acucugagcg ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag cucaugagga ucacccauga gcugacggua caggccacau      120

gaggaucacc caugugguau agugcagcau cagag                                 155


<210>  1087
<211>  99
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1087
acugggccuu cuaucugauu acucugaggc ccaucaccag cgacuauguc guagugggua       60

aagccgcuua gggacuucgg ucccuaagag gcaucagag                              99


<210>  1088
<211>  97
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1088
acugggccuu cuaucugauu acucugaggc ccaucaccag cgacuauguc guagugggua       60

aagcccuuag ggacuucggu cccuaagggc aucagag                                97


<210>  1089
<211>  99
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1089
acugggccuu cuaucugauu acucugaggc ccaucaccag cgacuauguc guagugggua       60

aagccucuua gggacuucgg ucccuaagag gcaucagag                              99


<210>  1090
<211>  89
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1090
acugggccuu cuaucugauu acucugaggc ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucagag                                         89


<210>  1091
<211>  97
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1091
acugggccuu cuaucugauu acucugaggc ccaucaccag cgacuauguc guagugggua       60

aagcccuuag ggaccuuggu cccuaagggc aucagag                                97


<210>  1092
<211>  99
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1092
acugggccuu cuaucugauu acucugaggc ccaucaccag cgacuauguc guagugggua       60

aagccucuua gggaccuugg ucccuaagag gcaucagag                              99


<210>  1093
<211>  89
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1093
acugggccuu cuaucugauu acucugaggc ccaucaccag cgacuauguc guagugggua       60

aagcucccuc cuuggaggga gcaucagag                                         89


<210>  1094
<211>  97
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1094
acugggccuu cuaucugauu acucugaggc ccaucaccag cgacuauguc guagugggua       60

aagcccuuag ggaggaaacu cccuaagggc aucagag                                97


<210>  1095
<211>  99
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1095
acugggccuu cuaucugauu acucugaggc ccaucaccag cgacuauguc guagugggua       60

aagccucuua gggaggaaac ucccuaagag gcaucagag                              99


<210>  1096
<211>  89
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1096
acugggccuu cuaucugauu acucugaggc ccaucaccag cgacuauguc guagugggua       60

aagcucccug gaaacaggga gcaucagag                                         89


<210>  1097
<211>  98
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1097
acugggccuu cuaucugauu acucugaggc ccaucaccag cgacuauguc guagugggua       60

aagcccuuag ggacuucagg ucccuaaggg caucagag                               98


<210>  1098
<211>  100
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1098
acugggccuu cuaucugauu acucugaggc ccaucaccag cgacuauguc guagugggua       60

aagccucuua gggacuucag gucccuaaga ggcaucagag                            100


<210>  1099
<211>  90
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1099
acugggccuu cuaucugauu acucugaggc ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucaggaggg agcaucagag                                        90


<210>  1100
<211>  97
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1100
acugggccuu cuaucugauu acucugaggc ccaucaccag gcacuaugug cuagugggua       60

aagcccuuag ggaccuuggu cccuaagggc aucagag                                97


<210>  1101
<211>  99
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1101
acugggccuu cuaucugauu acucugaggc ccaucaccag gcacuaugug cuagugggua       60

aagccucuua gggaccuugg ucccuaagag gcaucagag                              99


<210>  1102
<211>  89
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1102
acugggccuu cuaucugauu acucugaggc ccaucaccag gcacuaugug cuagugggua       60

aagcucccuc cuuggaggga gcaucagag                                         89


<210>  1103
<211>  97
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1103
acugggccuu cuaucugauu acucugaggc ccaucaccag gcacuaugug cuagugggua       60

aagcccuuag ggaggaaacu cccuaagggc aucagag                                97


<210>  1104
<211>  99
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1104
acugggccuu cuaucugauu acucugaggc ccaucaccag gcacuaugug cuagugggua       60

aagccucuua gggaggaaac ucccuaagag gcaucagag                              99


<210>  1105
<211>  89
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1105
acugggccuu cuaucugauu acucugaggc ccaucaccag gcacuaugug cuagugggua       60

aagcucccug gaaacaggga gcaucagag                                         89


<210>  1106
<211>  98
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1106
acugggccuu cuaucugauu acucugaggc ccaucaccag gcacuaugug cuagugggua       60

aagcccuuag ggacuucagg ucccuaaggg caucagag                               98


<210>  1107
<211>  100
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1107
acugggccuu cuaucugauu acucugaggc ccaucaccag gcacuaugug cuagugggua       60

aagccucuua gggacuucag gucccuaaga ggcaucagag                            100


<210>  1108
<211>  90
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1108
acugggccuu cuaucugauu acucugaggc ccaucaccag gcacuaugug cuagugggua       60

aagcucccuc uucaggaggg agcaucagag                                        90


<210>  1109
<211>  96
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1109
acuggcgcuu cuaucugauu acucugagcg ccaucaccag cgacuauguc guagugggua       60

aagcucacau gaggaucacc caugugagca ucagag                                 96


<210>  1110
<211>  145
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1110
acuggcgcuu cuaucugauu acucugagcg ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag cgucaaugac gcugacggua caggccacau gaggaucacc      120

caugugguau agugcagcau cagag                                            145


<210>  1111
<211>  155
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1111
acuggcgcuu cuaucugauu acucugagcg ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag cucaugagga ucacccauga gcugacggua caggccacau      120

gaggaucacc caugugguau agugcagcau cagag                                 155


<210>  1112
<211>  159
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1112
acuggcgcuu cuaucugauu acucugagcg ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag acauggcagu cguaacgacg cgggucugac gguacaggcc      120

acaugaggau cacccaugug guauagugca gcaucagag                             159


<210>  1113
<211>  145
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1113
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu auggggccac augaggauca cccauguggu guacagcgca gcgucaauga      120

cgcugacgau agugcagcau caaag                                            145


<210>  1114
<211>  436
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1114
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag cucaugagga ucacccauga gcugacggua caggccacau      120

gaggaucacc caugugguau agugcagcau caaagcugca uucuaguugu gguuucacaa      180

uuauucuuga guguagucuc gucauucacc aaaucuuugu uuggugcgcg cggccggcau      240

ggucccagcc uccucgcugg cgccggcugg gcaacauucc gaggggaccg uccccucggu      300

aauggcgaau gggacgucga cugcuaacaa agcccgaaag gaagcugagu uggcugcugc      360

caccgcugag caauaacuag cauaaccccu uggggccucu aaacgggucu ugagggguuu      420

uuugcugauu uuuuuu                                                      436


<210>  1115
<211>  272
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1115
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag cucaugagga ucacccauga gcugacggua caggccacau      120

gaggaucacc caugugguau agugcagcau caaagcugca uucuaguugu gguuuauggc      180

cggcaugguc ccagccuccu cgcuggcgcc ggcugggcaa cauuccgagg ggaccgcccc      240

cucgguaaug gcgaauggga cccauuuuuu uu                                    272


<210>  1116
<211>  271
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1116
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag cucaugagga ucacccauga gcugacggua caggccacau      120

gaggaucacc caugugguau agugcagcau caaagcugca uucuaguugu gguuuguggc      180

cggcaugguc cagccuacuc gcuggcgcgg gcugggcaac auuccgaggg gacccguccc      240

ucgguaaugg cgaaugggac ccauuuuuuu u                                     271


<210>  1117
<211>  274
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1117
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag cucaugagga ucacccauga gcugacggua caggccacau      120

gaggaucacc caugugguau agugcagcau caaagcugca uucuaguugu gguuuguggc      180

cggcauggcc ccagccuccu cgcuggcgcc ggcugggcaa cgauccgagg ggacuguccc      240

ucucgagaau cggcaaaugg ggccccuuuu uuuu                                  274


<210>  1118
<211>  283
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1118
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag cucaugagga ucacccauga gcugacggua caggccacau      120

gaggaucacc caugugguau agugcagcau caaagcugca uucuaguugu gguuuucggg      180

ucggcauggc aucuccaccu ccaccuccuc gcgguccgac cugggcaucc gaaggaggag      240

cggacgucca cucggauggc uaagggagag cccaguuuuu uuu                        283


<210>  1119
<211>  276
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1119
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag cucaugagga ucacccauga gcugacggua caggccacau      120

gaggaucacc caugugguau agugcagcau caaagcugca uucuaguugu gguuuucggg      180

ucggcauggc aucuccaccu ccccgugguc cgaccugggc auccgaagga ggacggacgu      240

ccacucggau ggcuaaggga gugccggcuu uuuuuu                                276


<210>  1120
<211>  251
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1120
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag cucaugagga ucacccauga gcugacggua caggccacau      120

gaggaucacc caugugguau agugcagcau caaagcugca uucuaguugu gguuuggccg      180

gcaugguccc agccuccucg cuggcgccgg cugggcaaca ugcuucggca uggcgaaugg      240

gacuuuuuuu u                                                           251


<210>  1121
<211>  377
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1121
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucacau gaggaucacc caugugagca ucaaagcugc auucuaguug ugguuucaca      120

auuauucuug aguguagucu cgucauucac caaaucuuug uuuggugcgc gcggccggca      180

uggucccagc cuccucgcug gcgccggcug ggcaacauuc cgaggggacc guccccucgg      240

uaauggcgaa ugggacgucg acugcuaaca aagcccgaaa ggaagcugag uuggcugcug      300

ccaccgcuga gcaauaacua gcauaacccc uuggggccuc uaaacggguc uugagggguu      360

uuuugcugau uuuuuuu                                                     377


<210>  1122
<211>  213
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1122
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucacau gaggaucacc caugugagca ucaaagcugc auucuaguug ugguuuaugg      120

ccggcauggu cccagccucc ucgcuggcgc cggcugggca acauuccgag gggaccgccc      180

ccucgguaau ggcgaauggg acccauuuuu uuu                                   213


<210>  1123
<211>  212
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1123
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucacau gaggaucacc caugugagca ucaaagcugc auucuaguug ugguuugugg      120

ccggcauggu ccagccuacu cgcuggcgcg ggcugggcaa cauuccgagg ggacccgucc      180

cucgguaaug gcgaauggga cccauuuuuu uu                                    212


<210>  1124
<211>  215
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1124
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucacau gaggaucacc caugugagca ucaaagcugc auucuaguug ugguuugugg      120

ccggcauggc cccagccucc ucgcuggcgc cggcugggca acgauccgag gggacugucc      180

cucucgagaa ucggcaaaug gggccccuuu uuuuu                                 215


<210>  1125
<211>  224
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1125
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucacau gaggaucacc caugugagca ucaaagcugc auucuaguug ugguuuucgg      120

gucggcaugg caucuccacc uccaccuccu cgcgguccga ccugggcauc cgaaggagga      180

gcggacgucc acucggaugg cuaagggaga gcccaguuuu uuuu                       224


<210>  1126
<211>  217
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1126
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucacau gaggaucacc caugugagca ucaaagcugc auucuaguug ugguuuucgg      120

gucggcaugg caucuccacc uccccguggu ccgaccuggg cauccgaagg aggacggacg      180

uccacucgga uggcuaaggg agugccggcu uuuuuuu                               217


<210>  1127
<211>  192
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1127
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucacau gaggaucacc caugugagca ucaaagcugc auucuaguug ugguuuggcc      120

ggcauggucc cagccuccuc gcuggcgccg gcugggcaac augcuucggc auggcgaaug      180

ggacuuuuuu uu                                                          192


<210>  1128
<211>  163
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1128
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag caaggaguuu auauggaaac ccuugcugac gguacaggcc      120

aaggaguuua uauggaaacc cuugguauag ugcagcauca aag                        163


<210>  1129
<211>  147
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1129
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag cgcccugaag aagggcgcug acgguacagg ccgcccugaa      120

gaagggcggu auagugcagc aucaaag                                          147


<210>  1130
<211>  173
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1130
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag cggcucgugu agcucauuag cuccgagccg cugacgguac      120

aggccggcuc guguagcuca uuagcuccga gccgguauag ugcagcauca aag             173


<210>  1131
<211>  177
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1131
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag cccgugugca uccgcagugu cggauccacg ggcugacggu      120

acaggccccg ugugcauccg cagugucgga uccacggggu auagugcagc aucaaag         177


<210>  1132
<211>  161
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1132
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag cauccauugc acuccggaua gcugcugacg guacaggcca      120

uccauugcac uccggauagc ugguauagug cagcaucaaa g                          161


<210>  1133
<211>  157
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1133
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag caugcauguc uaagacagca ugcugacggu acaggccaug      120

caugucuaag acagcauggu auagugcagc aucaaag                               157


<210>  1134
<211>  162
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1134
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag caaaacauaa ggaaaaccua uguucugacg guacaggcca      120

aaacauaagg aaaaccuaug uugguauagu gcagcaucaa ag                         162


<210>  1135
<211>  175
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1135
acuggcgcuu cuaucugauu acucugagcg ccaucaccag cgacuauguc guagugggua       60

aagccgcuua cggacuaugg gcgcagcaag gaguuuauau ggaaacccuu gcugacggua      120

caggccaagg aguuuauaug gaaacccuug guauaguccg uaagaggcau cagag           175


<210>  1136
<211>  159
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1136
acuggcgcuu cuaucugauu acucugagcg ccaucaccag cgacuauguc guagugggua       60

aagccgcuua cggacuaugg gcgcagcgcc cugaagaagg gcgcugacgg uacaggccgc      120

ccugaagaag ggcgguauag uccguaagag gcaucagag                             159


<210>  1137
<211>  185
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1137
acuggcgcuu cuaucugauu acucugagcg ccaucaccag cgacuauguc guagugggua       60

aagccgcuua cggacuaugg gcgcagcggc ucguguagcu cauuagcucc gagccgcuga      120

cgguacaggc cggcucgugu agcucauuag cuccgagccg guauaguccg uaagaggcau      180

cagag                                                                  185


<210>  1138
<211>  189
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1138
acuggcgcuu cuaucugauu acucugagcg ccaucaccag cgacuauguc guagugggua       60

aagccgcuua cggacuaugg gcgcagcccg ugugcauccg cagugucgga uccacgggcu      120

gacgguacag gccccgugug cauccgcagu gucggaucca cgggguauag uccguaagag      180

gcaucagag                                                              189


<210>  1139
<211>  173
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1139
acuggcgcuu cuaucugauu acucugagcg ccaucaccag cgacuauguc guagugggua       60

aagccgcuua cggacuaugg gcgcagcauc cauugcacuc cggauagcug cugacgguac      120

aggccaucca uugcacuccg gauagcuggu auaguccgua agaggcauca gag             173


<210>  1140
<211>  169
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1140
acuggcgcuu cuaucugauu acucugagcg ccaucaccag cgacuauguc guagugggua       60

aagccgcuua cggacuaugg gcgcagcaug caugucuaag acagcaugcu gacgguacag      120

gccaugcaug ucuaagacag caugguauag uccguaagag gcaucagag                  169


<210>  1141
<211>  175
<212>  RNA
<213>  ArtSeq 	variant guide RNA

<400>  1141
acuggcgcuu cuaucugauu acucugagcg ccaucaccag cgacuauguc guagugggua       60

aagccgcuua cggacuaugg gcgcagcaaa acauaaggaa aaccuauguu gcugacggua      120

caggccaaaa cauaaggaaa accuauguug guauaguccg uaagaggcau cagag           175


<210>  1142
<211>  511
<212>  PRT
<213>  Vesicular stomatitis virus

<400>  1142

Met Lys Cys Leu Leu Tyr Leu Ala Phe Leu Phe Ile Gly Val Asn Cys 
1               5                   10                  15      


Lys Phe Thr Ile Val Phe Pro His Asn Gln Lys Gly Asn Trp Lys Asn 
            20                  25                  30          


Val Pro Ser Asn Tyr His Tyr Cys Pro Ser Ser Ser Asp Leu Asn Trp 
        35                  40                  45              


His Asn Asp Leu Ile Gly Thr Ala Leu Gln Val Lys Met Pro Lys Ser 
    50                  55                  60                  


His Lys Ala Ile Gln Ala Asp Gly Trp Met Cys His Ala Ser Lys Trp 
65                  70                  75                  80  


Val Thr Thr Cys Asp Phe Arg Trp Tyr Gly Pro Lys Tyr Ile Thr His 
                85                  90                  95      


Ser Ile Arg Ser Phe Thr Pro Ser Val Glu Gln Cys Lys Glu Ser Ile 
            100                 105                 110         


Glu Gln Thr Lys Gln Gly Thr Trp Leu Asn Pro Gly Phe Pro Pro Gln 
        115                 120                 125             


Ser Cys Gly Tyr Ala Thr Val Thr Asp Ala Glu Ala Val Ile Val Gln 
    130                 135                 140                 


Val Thr Pro His His Val Leu Val Asp Glu Tyr Thr Gly Glu Trp Val 
145                 150                 155                 160 


Asp Ser Gln Phe Ile Asn Gly Lys Cys Ser Asn Tyr Ile Cys Pro Thr 
                165                 170                 175     


Val His Asn Ser Thr Thr Trp His Ser Asp Tyr Lys Val Lys Gly Leu 
            180                 185                 190         


Cys Asp Ser Asn Leu Ile Ser Met Asp Ile Thr Phe Phe Ser Glu Asp 
        195                 200                 205             


Gly Glu Leu Ser Ser Leu Gly Lys Glu Gly Thr Gly Phe Arg Ser Asn 
    210                 215                 220                 


Tyr Phe Ala Tyr Glu Thr Gly Gly Lys Ala Cys Lys Met Gln Tyr Cys 
225                 230                 235                 240 


Lys His Trp Gly Val Arg Leu Pro Ser Gly Val Trp Phe Glu Met Ala 
                245                 250                 255     


Asp Lys Asp Leu Phe Ala Ala Ala Arg Phe Pro Glu Cys Pro Glu Gly 
            260                 265                 270         


Ser Ser Ile Ser Ala Pro Ser Gln Thr Ser Val Asp Val Ser Leu Ile 
        275                 280                 285             


Gln Asp Val Glu Arg Ile Leu Asp Tyr Ser Leu Cys Gln Glu Thr Trp 
    290                 295                 300                 


Ser Lys Ile Arg Ala Gly Leu Pro Ile Ser Pro Val Asp Leu Ser Tyr 
305                 310                 315                 320 


Leu Ala Pro Lys Asn Pro Gly Thr Gly Pro Ala Phe Thr Ile Ile Asn 
                325                 330                 335     


Gly Thr Leu Lys Tyr Phe Glu Thr Arg Tyr Ile Arg Val Asp Ile Ala 
            340                 345                 350         


Ala Pro Ile Leu Ser Arg Met Val Gly Met Ile Ser Gly Thr Thr Thr 
        355                 360                 365             


Glu Arg Glu Leu Trp Asp Asp Trp Ala Pro Tyr Glu Asp Val Glu Ile 
    370                 375                 380                 


Gly Pro Asn Gly Val Leu Arg Thr Ser Ser Gly Tyr Lys Phe Pro Leu 
385                 390                 395                 400 


Tyr Met Ile Gly His Gly Met Leu Asp Ser Asp Leu His Leu Ser Ser 
                405                 410                 415     


Lys Ala Gln Val Phe Glu His Pro His Ile Gln Asp Ala Ala Ser Gln 
            420                 425                 430         


Leu Pro Asp Asp Glu Ser Leu Phe Phe Gly Asp Thr Gly Leu Ser Lys 
        435                 440                 445             


Asn Pro Ile Glu Leu Val Glu Gly Trp Phe Ser Ser Trp Lys Ser Ser 
    450                 455                 460                 


Ile Ala Ser Phe Phe Phe Ile Ile Gly Leu Ile Ile Gly Leu Phe Leu 
465                 470                 475                 480 


Val Leu Arg Val Gly Ile His Leu Cys Ile Lys Leu Lys His Thr Lys 
                485                 490                 495     


Lys Arg Gln Ile Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Lys 
            500                 505                 510     


<210>  1143
<211>  451
<212>  PRT
<213>  Vesicular stomatitis virus

<400>  1143

Lys Phe Thr Ile Val Phe Pro His Asn Gln Lys Gly Asn Trp Lys Asn 
1               5                   10                  15      


Val Pro Ser Asn Tyr His Tyr Cys Pro Ser Ser Ser Asp Leu Asn Trp 
            20                  25                  30          


His Asn Asp Leu Ile Gly Thr Ala Leu Gln Val Lys Met Pro Lys Ser 
        35                  40                  45              


His Lys Ala Ile Gln Ala Asp Gly Trp Met Cys His Ala Ser Lys Trp 
    50                  55                  60                  


Val Thr Thr Cys Asp Phe Arg Trp Tyr Gly Pro Lys Tyr Ile Thr His 
65                  70                  75                  80  


Ser Ile Arg Ser Phe Thr Pro Ser Val Glu Gln Cys Lys Glu Ser Ile 
                85                  90                  95      


Glu Gln Thr Lys Gln Gly Thr Trp Leu Asn Pro Gly Phe Pro Pro Gln 
            100                 105                 110         


Ser Cys Gly Tyr Ala Thr Val Thr Asp Ala Glu Ala Val Ile Val Gln 
        115                 120                 125             


Val Thr Pro His His Val Leu Val Asp Glu Tyr Thr Gly Glu Trp Val 
    130                 135                 140                 


Asp Ser Gln Phe Ile Asn Gly Lys Cys Ser Asn Tyr Ile Cys Pro Thr 
145                 150                 155                 160 


Val His Asn Ser Thr Thr Trp His Ser Asp Tyr Lys Val Lys Gly Leu 
                165                 170                 175     


Cys Asp Ser Asn Leu Ile Ser Met Asp Ile Thr Phe Phe Ser Glu Asp 
            180                 185                 190         


Gly Glu Leu Ser Ser Leu Gly Lys Glu Gly Thr Gly Phe Arg Ser Asn 
        195                 200                 205             


Tyr Phe Ala Tyr Glu Thr Gly Gly Lys Ala Cys Lys Met Gln Tyr Cys 
    210                 215                 220                 


Lys His Trp Gly Val Arg Leu Pro Ser Gly Val Trp Phe Glu Met Ala 
225                 230                 235                 240 


Asp Lys Asp Leu Phe Ala Ala Ala Arg Phe Pro Glu Cys Pro Glu Gly 
                245                 250                 255     


Ser Ser Ile Ser Ala Pro Ser Gln Thr Ser Val Asp Val Ser Leu Ile 
            260                 265                 270         


Gln Asp Val Glu Arg Ile Leu Asp Tyr Ser Leu Cys Gln Glu Thr Trp 
        275                 280                 285             


Ser Lys Ile Arg Ala Gly Leu Pro Ile Ser Pro Val Asp Leu Ser Tyr 
    290                 295                 300                 


Leu Ala Pro Lys Asn Pro Gly Thr Gly Pro Ala Phe Thr Ile Ile Asn 
305                 310                 315                 320 


Gly Thr Leu Lys Tyr Phe Glu Thr Arg Tyr Ile Arg Val Asp Ile Ala 
                325                 330                 335     


Ala Pro Ile Leu Ser Arg Met Val Gly Met Ile Ser Gly Thr Thr Thr 
            340                 345                 350         


Glu Arg Glu Leu Trp Asp Asp Trp Ala Pro Tyr Glu Asp Val Glu Ile 
        355                 360                 365             


Gly Pro Asn Gly Val Leu Arg Thr Ser Ser Gly Tyr Lys Phe Pro Leu 
    370                 375                 380                 


Tyr Met Ile Gly His Gly Met Leu Asp Ser Asp Leu His Leu Ser Ser 
385                 390                 395                 400 


Lys Ala Gln Val Phe Glu His Pro His Ile Gln Asp Ala Ala Ser Gln 
                405                 410                 415     


Leu Pro Asp Asp Glu Ser Leu Phe Phe Gly Asp Thr Gly Leu Ser Lys 
            420                 425                 430         


Asn Pro Ile Glu Leu Val Glu Gly Trp Phe Ser Ser Trp Lys Ser Ser 
        435                 440                 445             


Ile Ala Ser 
    450     


<210>  1144
<211>  21
<212>  PRT
<213>  Vesicular stomatitis virus

<400>  1144

Phe Phe Phe Ile Ile Gly Leu Ile Ile Gly Leu Phe Leu Val Leu Arg 
1               5                   10                  15      


Val Gly Ile His Leu 
            20      


<210>  1145
<211>  23
<212>  PRT
<213>  Vesicular stomatitis virus

<400>  1145

Cys Ile Lys Leu Lys His Thr Lys Lys Arg Gln Ile Tyr Thr Asp Ile 
1               5                   10                  15      


Glu Met Asn Arg Leu Gly Lys 
            20              


<210>  1146
<211>  512
<212>  PRT
<213>  Vesiculovirus Maraba vesiculovirus

<400>  1146

Met Leu Arg Leu Phe Leu Phe Cys Phe Leu Ala Leu Gly Ala His Ser 
1               5                   10                  15      


Lys Phe Thr Ile Val Phe Pro His His Gln Lys Gly Asn Trp Lys Asn 
            20                  25                  30          


Val Pro Ser Thr Tyr His Tyr Cys Pro Ser Ser Ser Asp Gln Asn Trp 
        35                  40                  45              


His Asn Asp Leu Thr Gly Val Ser Leu His Val Lys Ile Pro Lys Ser 
    50                  55                  60                  


His Lys Ala Ile Gln Ala Asp Gly Trp Met Cys His Ala Ala Lys Trp 
65                  70                  75                  80  


Val Thr Thr Cys Asp Phe Arg Trp Tyr Gly Pro Lys Tyr Ile Thr His 
                85                  90                  95      


Ser Ile His Ser Met Ser Pro Thr Leu Glu Gln Cys Lys Thr Ser Ile 
            100                 105                 110         


Glu Gln Thr Lys Gln Gly Val Trp Ile Asn Pro Gly Phe Pro Pro Gln 
        115                 120                 125             


Ser Cys Gly Tyr Ala Thr Val Thr Asp Ala Glu Val Val Val Val Gln 
    130                 135                 140                 


Ala Thr Pro His His Val Leu Val Asp Glu Tyr Thr Gly Glu Trp Ile 
145                 150                 155                 160 


Asp Ser Gln Leu Val Gly Gly Lys Cys Ser Lys Glu Val Cys Gln Thr 
                165                 170                 175     


Val His Asn Ser Thr Val Trp His Ala Asp Tyr Lys Ile Thr Gly Leu 
            180                 185                 190         


Cys Glu Ser Asn Leu Ala Ser Val Asp Ile Thr Phe Phe Ser Glu Asp 
        195                 200                 205             


Gly Gln Lys Thr Ser Leu Gly Lys Pro Asn Thr Gly Phe Arg Ser Asn 
    210                 215                 220                 


His Phe Ala Tyr Glu Ser Gly Glu Lys Ala Cys Arg Met Gln Tyr Cys 
225                 230                 235                 240 


Thr Gln Trp Gly Ile Arg Leu Pro Ser Gly Val Trp Phe Glu Leu Val 
                245                 250                 255     


Asp Lys Asp Leu Phe Gln Ala Ala Lys Leu Pro Glu Cys Pro Arg Gly 
            260                 265                 270         


Ser Ser Ile Ser Ala Pro Ser Gln Thr Ser Val Asp Val Ser Leu Ile 
        275                 280                 285             


Gln Asp Val Glu Arg Ile Leu Asp Tyr Ser Leu Cys Gln Glu Thr Trp 
    290                 295                 300                 


Ser Lys Ile Arg Ala Lys Leu Pro Val Ser Pro Val Asp Leu Ser Tyr 
305                 310                 315                 320 


Leu Ala Pro Lys Asn Pro Gly Ser Gly Pro Ala Phe Thr Ile Ile Asn 
                325                 330                 335     


Gly Thr Leu Lys Tyr Phe Glu Thr Arg Tyr Ile Arg Val Asp Ile Ser 
            340                 345                 350         


Asn Pro Ile Ile Pro His Met Val Gly Thr Met Ser Gly Thr Thr Thr 
        355                 360                 365             


Glu Arg Glu Leu Trp Asn Asp Trp Tyr Pro Tyr Glu Asp Val Glu Ile 
    370                 375                 380                 


Gly Pro Asn Gly Val Leu Lys Thr Pro Thr Gly Phe Lys Phe Pro Leu 
385                 390                 395                 400 


Tyr Met Ile Gly His Gly Met Leu Asp Ser Asp Leu His Lys Ser Ser 
                405                 410                 415     


Gln Ala Gln Val Phe Glu His Pro His Ala Lys Asp Ala Ala Ser Gln 
            420                 425                 430         


Leu Pro Asp Asp Glu Thr Leu Phe Phe Gly Asp Thr Gly Leu Ser Lys 
        435                 440                 445             


Asn Pro Val Glu Leu Val Glu Gly Trp Phe Ser Ser Trp Lys Ser Thr 
    450                 455                 460                 


Leu Ala Ser Phe Phe Leu Ile Ile Gly Leu Gly Val Ala Leu Ile Phe 
465                 470                 475                 480 


Ile Ile Arg Ile Ile Val Ala Ile Arg Tyr Lys Tyr Lys Gly Arg Lys 
                485                 490                 495     


Thr Gln Lys Ile Tyr Asn Asp Val Glu Met Ser Arg Leu Gly Asn Lys 
            500                 505                 510         


<210>  1147
<211>  448
<212>  PRT
<213>  Vesiculovirus Maraba vesiculovirus

<400>  1147

Lys Phe Thr Ile Val Phe Pro His His Gln Lys Gly Asn Trp Lys Asn 
1               5                   10                  15      


Val Pro Ser Thr Tyr His Tyr Cys Pro Ser Ser Ser Asp Gln Asn Trp 
            20                  25                  30          


His Asn Asp Leu Thr Gly Val Ser Leu His Val Lys Ile Pro Lys Ser 
        35                  40                  45              


His Lys Ala Ile Gln Ala Asp Gly Trp Met Cys His Ala Ala Lys Trp 
    50                  55                  60                  


Val Thr Thr Cys Asp Phe Arg Trp Tyr Gly Pro Lys Tyr Ile Thr His 
65                  70                  75                  80  


Ser Ile His Ser Met Ser Pro Thr Leu Glu Gln Cys Lys Thr Ser Ile 
                85                  90                  95      


Glu Gln Thr Lys Gln Gly Val Trp Ile Asn Pro Gly Phe Pro Pro Gln 
            100                 105                 110         


Ser Cys Gly Tyr Ala Thr Val Thr Asp Ala Glu Val Val Val Val Gln 
        115                 120                 125             


Ala Thr Pro His His Val Leu Val Asp Glu Tyr Thr Gly Glu Trp Ile 
    130                 135                 140                 


Asp Ser Gln Leu Val Gly Gly Lys Cys Ser Lys Glu Val Cys Gln Thr 
145                 150                 155                 160 


Val His Asn Ser Thr Val Trp His Ala Asp Tyr Lys Ile Thr Gly Leu 
                165                 170                 175     


Cys Glu Ser Asn Leu Ala Ser Val Asp Ile Thr Phe Phe Ser Glu Asp 
            180                 185                 190         


Gly Gln Lys Thr Ser Leu Gly Lys Pro Asn Thr Gly Phe Arg Ser Asn 
        195                 200                 205             


His Phe Ala Tyr Glu Ser Gly Glu Lys Ala Cys Arg Met Gln Tyr Cys 
    210                 215                 220                 


Thr Gln Trp Gly Ile Arg Leu Pro Ser Gly Val Trp Phe Glu Leu Val 
225                 230                 235                 240 


Asp Lys Asp Leu Phe Gln Ala Ala Lys Leu Pro Glu Cys Pro Arg Gly 
                245                 250                 255     


Ser Ser Ile Ser Ala Pro Ser Gln Thr Ser Val Asp Val Ser Leu Ile 
            260                 265                 270         


Gln Asp Val Glu Arg Ile Leu Asp Tyr Ser Leu Cys Gln Glu Thr Trp 
        275                 280                 285             


Ser Lys Ile Arg Ala Lys Leu Pro Val Ser Pro Val Asp Leu Ser Tyr 
    290                 295                 300                 


Leu Ala Pro Lys Asn Pro Gly Ser Gly Pro Ala Phe Thr Ile Ile Asn 
305                 310                 315                 320 


Gly Thr Leu Lys Tyr Phe Glu Thr Arg Tyr Ile Arg Val Asp Ile Ser 
                325                 330                 335     


Asn Pro Ile Ile Pro His Met Val Gly Thr Met Ser Gly Thr Thr Thr 
            340                 345                 350         


Glu Arg Glu Leu Trp Asn Asp Trp Tyr Pro Tyr Glu Asp Val Glu Ile 
        355                 360                 365             


Gly Pro Asn Gly Val Leu Lys Thr Pro Thr Gly Phe Lys Phe Pro Leu 
    370                 375                 380                 


Tyr Met Ile Gly His Gly Met Leu Asp Ser Asp Leu His Lys Ser Ser 
385                 390                 395                 400 


Gln Ala Gln Val Phe Glu His Pro His Ala Lys Asp Ala Ala Ser Gln 
                405                 410                 415     


Leu Pro Asp Asp Glu Thr Leu Phe Phe Gly Asp Thr Gly Leu Ser Lys 
            420                 425                 430         


Asn Pro Val Glu Leu Val Glu Gly Trp Phe Ser Ser Trp Lys Ser Thr 
        435                 440                 445             


<210>  1148
<211>  22
<212>  PRT
<213>  Vesiculovirus Maraba vesiculovirus

<400>  1148

Leu Ala Ser Phe Phe Leu Ile Ile Gly Leu Gly Val Ala Leu Ile Phe 
1               5                   10                  15      


Ile Ile Arg Ile Ile Val 
            20          


<210>  1149
<211>  26
<212>  PRT
<213>  Vesiculovirus Maraba vesiculovirus

<400>  1149

Ala Ile Arg Tyr Lys Tyr Lys Gly Arg Lys Thr Gln Lys Ile Tyr Asn 
1               5                   10                  15      


Asp Val Glu Met Ser Arg Leu Gly Asn Lys 
            20                  25      


<210>  1150
<211>  512
<212>  PRT
<213>  Vesiculovirus Cocal vesiculovirus

<400>  1150

Met Asn Phe Leu Leu Leu Thr Phe Ile Val Leu Pro Leu Cys Ser His 
1               5                   10                  15      


Ala Lys Phe Ser Ile Val Phe Pro Gln Ser Gln Lys Gly Asn Trp Lys 
            20                  25                  30          


Asn Val Pro Ser Ser Tyr His Tyr Cys Pro Ser Ser Ser Asp Gln Asn 
        35                  40                  45              


Trp His Asn Asp Leu Leu Gly Ile Thr Met Lys Val Lys Met Pro Lys 
    50                  55                  60                  


Thr His Lys Ala Ile Gln Ala Asp Gly Trp Met Cys His Ala Ala Lys 
65                  70                  75                  80  


Trp Ile Thr Thr Cys Asp Phe Arg Trp Tyr Gly Pro Lys Tyr Ile Thr 
                85                  90                  95      


His Ser Ile His Ser Ile Gln Pro Thr Ser Glu Gln Cys Lys Glu Ser 
            100                 105                 110         


Ile Lys Gln Thr Lys Gln Gly Thr Trp Met Ser Pro Gly Phe Pro Pro 
        115                 120                 125             


Gln Asn Cys Gly Tyr Ala Thr Val Thr Asp Ser Val Ala Val Val Val 
    130                 135                 140                 


Gln Ala Thr Pro His His Val Leu Val Asp Glu Tyr Thr Gly Glu Trp 
145                 150                 155                 160 


Ile Asp Ser Gln Phe Pro Asn Gly Lys Cys Glu Thr Glu Glu Cys Glu 
                165                 170                 175     


Thr Val His Asn Ser Thr Val Trp Tyr Ser Asp Tyr Lys Val Thr Gly 
            180                 185                 190         


Leu Cys Asp Ala Thr Leu Val Asp Thr Glu Ile Thr Phe Phe Ser Glu 
        195                 200                 205             


Asp Gly Lys Lys Glu Ser Ile Gly Lys Pro Asn Thr Gly Tyr Arg Ser 
    210                 215                 220                 


Asn Tyr Phe Ala Tyr Glu Lys Gly Asp Lys Val Cys Lys Met Asn Tyr 
225                 230                 235                 240 


Cys Lys His Ala Gly Val Arg Leu Pro Ser Gly Val Trp Phe Glu Phe 
                245                 250                 255     


Val Asp Gln Asp Val Tyr Ala Ala Ala Lys Leu Pro Glu Cys Pro Val 
            260                 265                 270         


Gly Ala Thr Ile Ser Ala Pro Thr Gln Thr Ser Val Asp Val Ser Leu 
        275                 280                 285             


Ile Leu Asp Val Glu Arg Ile Leu Asp Tyr Ser Leu Cys Gln Glu Thr 
    290                 295                 300                 


Trp Ser Lys Ile Arg Ser Lys Gln Pro Val Ser Pro Val Asp Leu Ser 
305                 310                 315                 320 


Tyr Leu Ala Pro Lys Asn Pro Gly Thr Gly Pro Ala Phe Thr Ile Ile 
                325                 330                 335     


Asn Gly Thr Leu Lys Tyr Phe Glu Thr Arg Tyr Ile Arg Ile Asp Ile 
            340                 345                 350         


Asp Asn Pro Ile Ile Ser Lys Met Val Gly Lys Ile Ser Gly Ser Gln 
        355                 360                 365             


Thr Glu Arg Glu Leu Trp Thr Glu Trp Phe Pro Tyr Glu Gly Val Glu 
    370                 375                 380                 


Ile Gly Pro Asn Gly Ile Leu Lys Thr Pro Thr Gly Tyr Lys Phe Pro 
385                 390                 395                 400 


Leu Phe Met Ile Gly His Gly Met Leu Asp Ser Asp Leu His Lys Thr 
                405                 410                 415     


Ser Gln Ala Glu Val Phe Glu His Pro His Leu Ala Glu Ala Pro Lys 
            420                 425                 430         


Gln Leu Pro Glu Glu Glu Thr Leu Phe Phe Gly Asp Thr Gly Ile Ser 
        435                 440                 445             


Lys Asn Pro Val Glu Leu Ile Glu Gly Trp Phe Ser Ser Trp Lys Ser 
    450                 455                 460                 


Thr Val Val Thr Phe Phe Phe Ala Ile Gly Val Phe Ile Leu Leu Tyr 
465                 470                 475                 480 


Val Val Ala Arg Ile Val Ile Ala Val Arg Tyr Arg Tyr Gln Gly Ser 
                485                 490                 495     


Asn Asn Lys Arg Ile Tyr Asn Asp Ile Glu Met Ser Arg Phe Arg Lys 
            500                 505                 510         


<210>  1151
<211>  451
<212>  PRT
<213>  Vesiculovirus Cocal vesiculovirus

<400>  1151

Lys Phe Ser Ile Val Phe Pro Gln Ser Gln Lys Gly Asn Trp Lys Asn 
1               5                   10                  15      


Val Pro Ser Ser Tyr His Tyr Cys Pro Ser Ser Ser Asp Gln Asn Trp 
            20                  25                  30          


His Asn Asp Leu Leu Gly Ile Thr Met Lys Val Lys Met Pro Lys Thr 
        35                  40                  45              


His Lys Ala Ile Gln Ala Asp Gly Trp Met Cys His Ala Ala Lys Trp 
    50                  55                  60                  


Ile Thr Thr Cys Asp Phe Arg Trp Tyr Gly Pro Lys Tyr Ile Thr His 
65                  70                  75                  80  


Ser Ile His Ser Ile Gln Pro Thr Ser Glu Gln Cys Lys Glu Ser Ile 
                85                  90                  95      


Lys Gln Thr Lys Gln Gly Thr Trp Met Ser Pro Gly Phe Pro Pro Gln 
            100                 105                 110         


Asn Cys Gly Tyr Ala Thr Val Thr Asp Ser Val Ala Val Val Val Gln 
        115                 120                 125             


Ala Thr Pro His His Val Leu Val Asp Glu Tyr Thr Gly Glu Trp Ile 
    130                 135                 140                 


Asp Ser Gln Phe Pro Asn Gly Lys Cys Glu Thr Glu Glu Cys Glu Thr 
145                 150                 155                 160 


Val His Asn Ser Thr Val Trp Tyr Ser Asp Tyr Lys Val Thr Gly Leu 
                165                 170                 175     


Cys Asp Ala Thr Leu Val Asp Thr Glu Ile Thr Phe Phe Ser Glu Asp 
            180                 185                 190         


Gly Lys Lys Glu Ser Ile Gly Lys Pro Asn Thr Gly Tyr Arg Ser Asn 
        195                 200                 205             


Tyr Phe Ala Tyr Glu Lys Gly Asp Lys Val Cys Lys Met Asn Tyr Cys 
    210                 215                 220                 


Lys His Ala Gly Val Arg Leu Pro Ser Gly Val Trp Phe Glu Phe Val 
225                 230                 235                 240 


Asp Gln Asp Val Tyr Ala Ala Ala Lys Leu Pro Glu Cys Pro Val Gly 
                245                 250                 255     


Ala Thr Ile Ser Ala Pro Thr Gln Thr Ser Val Asp Val Ser Leu Ile 
            260                 265                 270         


Leu Asp Val Glu Arg Ile Leu Asp Tyr Ser Leu Cys Gln Glu Thr Trp 
        275                 280                 285             


Ser Lys Ile Arg Ser Lys Gln Pro Val Ser Pro Val Asp Leu Ser Tyr 
    290                 295                 300                 


Leu Ala Pro Lys Asn Pro Gly Thr Gly Pro Ala Phe Thr Ile Ile Asn 
305                 310                 315                 320 


Gly Thr Leu Lys Tyr Phe Glu Thr Arg Tyr Ile Arg Ile Asp Ile Asp 
                325                 330                 335     


Asn Pro Ile Ile Ser Lys Met Val Gly Lys Ile Ser Gly Ser Gln Thr 
            340                 345                 350         


Glu Arg Glu Leu Trp Thr Glu Trp Phe Pro Tyr Glu Gly Val Glu Ile 
        355                 360                 365             


Gly Pro Asn Gly Ile Leu Lys Thr Pro Thr Gly Tyr Lys Phe Pro Leu 
    370                 375                 380                 


Phe Met Ile Gly His Gly Met Leu Asp Ser Asp Leu His Lys Thr Ser 
385                 390                 395                 400 


Gln Ala Glu Val Phe Glu His Pro His Leu Ala Glu Ala Pro Lys Gln 
                405                 410                 415     


Leu Pro Glu Glu Glu Thr Leu Phe Phe Gly Asp Thr Gly Ile Ser Lys 
            420                 425                 430         


Asn Pro Val Glu Leu Ile Glu Gly Trp Phe Ser Ser Trp Lys Ser Thr 
        435                 440                 445             


Val Val Thr 
    450     


<210>  1152
<211>  21
<212>  PRT
<213>  Vesiculovirus Cocal vesiculovirus

<400>  1152

Phe Phe Phe Ala Ile Gly Val Phe Ile Leu Leu Tyr Val Val Ala Arg 
1               5                   10                  15      


Ile Val Ile Ala Val 
            20      


<210>  1153
<211>  23
<212>  PRT
<213>  Vesiculovirus Cocal vesiculovirus

<400>  1153

Arg Tyr Arg Tyr Gln Gly Ser Asn Asn Lys Arg Ile Tyr Asn Asp Ile 
1               5                   10                  15      


Glu Met Ser Arg Phe Arg Lys 
            20              


<210>  1154
<211>  524
<212>  PRT
<213>  Lyssavirus Rabies lyssavirus

<400>  1154

Met Val Pro Gln Ala Leu Leu Phe Val Pro Leu Leu Val Phe Pro Leu 
1               5                   10                  15      


Cys Phe Gly Lys Phe Pro Ile Tyr Thr Ile Leu Asp Lys Leu Gly Pro 
            20                  25                  30          


Trp Ser Pro Ile Asp Ile His His Leu Ser Cys Pro Asn Asn Leu Val 
        35                  40                  45              


Val Glu Asp Glu Gly Cys Thr Asn Leu Ser Gly Phe Ser Tyr Met Glu 
    50                  55                  60                  


Leu Lys Val Gly Tyr Ile Leu Ala Ile Lys Met Asn Gly Phe Thr Cys 
65                  70                  75                  80  


Thr Gly Val Val Thr Glu Ala Glu Thr Tyr Thr Asn Phe Val Gly Tyr 
                85                  90                  95      


Val Thr Thr Thr Phe Lys Arg Lys His Phe Arg Pro Thr Pro Asp Ala 
            100                 105                 110         


Cys Arg Ala Ala Tyr Asn Trp Lys Met Ala Gly Asp Pro Arg Tyr Glu 
        115                 120                 125             


Glu Ser Leu His Asn Pro Tyr Pro Asp Tyr Arg Trp Leu Arg Thr Val 
    130                 135                 140                 


Lys Thr Thr Lys Glu Ser Leu Val Ile Ile Ser Pro Ser Val Ala Asp 
145                 150                 155                 160 


Leu Asp Pro Tyr Asp Arg Ser Leu His Ser Arg Val Phe Pro Ser Gly 
                165                 170                 175     


Lys Cys Ser Gly Val Ala Val Ser Ser Thr Tyr Cys Ser Thr Asn His 
            180                 185                 190         


Asp Tyr Thr Ile Trp Met Pro Glu Asn Pro Arg Leu Gly Met Ser Cys 
        195                 200                 205             


Asp Ile Phe Thr Asn Ser Arg Gly Lys Arg Ala Ser Lys Gly Ser Glu 
    210                 215                 220                 


Thr Cys Gly Phe Val Asp Glu Arg Gly Leu Tyr Lys Ser Leu Lys Gly 
225                 230                 235                 240 


Ala Cys Lys Leu Lys Leu Cys Gly Val Leu Gly Leu Arg Leu Met Asp 
                245                 250                 255     


Gly Thr Trp Val Ala Met Gln Thr Ser Asn Glu Thr Lys Trp Cys Pro 
            260                 265                 270         


Pro Asp Gln Leu Val Asn Leu His Asp Phe Arg Ser Asp Glu Ile Glu 
        275                 280                 285             


His Leu Val Val Glu Glu Leu Val Arg Lys Arg Glu Glu Cys Leu Asp 
    290                 295                 300                 


Ala Leu Glu Ser Ile Met Thr Thr Lys Ser Val Ser Phe Arg Arg Leu 
305                 310                 315                 320 


Ser His Leu Arg Lys Leu Val Pro Gly Phe Gly Lys Ala Tyr Thr Ile 
                325                 330                 335     


Phe Asn Lys Thr Leu Met Glu Ala Asp Ala His Tyr Lys Ser Val Arg 
            340                 345                 350         


Thr Trp Asn Glu Ile Leu Pro Ser Lys Gly Cys Leu Arg Val Gly Gly 
        355                 360                 365             


Arg Cys His Pro His Val Asn Gly Val Phe Phe Asn Gly Ile Ile Leu 
    370                 375                 380                 


Gly Pro Asp Gly Asn Val Leu Ile Pro Glu Met Gln Ser Ser Leu Leu 
385                 390                 395                 400 


Gln Gln His Met Glu Leu Leu Glu Ser Ser Val Ile Pro Leu Val His 
                405                 410                 415     


Pro Leu Ala Asp Pro Ser Thr Val Phe Lys Asp Gly Asp Glu Ala Glu 
            420                 425                 430         


Asp Phe Val Glu Val His Leu Pro Asp Val His Asn Gln Val Ser Gly 
        435                 440                 445             


Val Asp Leu Gly Leu Pro Asn Trp Gly Lys Tyr Val Leu Leu Ser Ala 
    450                 455                 460                 


Gly Ala Leu Thr Ala Leu Met Leu Ile Ile Phe Leu Met Thr Cys Cys 
465                 470                 475                 480 


Arg Arg Val Asn Arg Ser Glu Pro Thr Gln His Asn Leu Arg Gly Thr 
                485                 490                 495     


Gly Arg Glu Val Ser Val Thr Pro Gln Ser Gly Lys Ile Ile Ser Ser 
            500                 505                 510         


Trp Glu Ser His Lys Ser Gly Gly Glu Thr Arg Leu 
        515                 520                 


<210>  1155
<211>  440
<212>  PRT
<213>  Lyssavirus Rabies lyssavirus

<400>  1155

Lys Phe Pro Ile Tyr Thr Ile Leu Asp Lys Leu Gly Pro Trp Ser Pro 
1               5                   10                  15      


Ile Asp Ile His His Leu Ser Cys Pro Asn Asn Leu Val Val Glu Asp 
            20                  25                  30          


Glu Gly Cys Thr Asn Leu Ser Gly Phe Ser Tyr Met Glu Leu Lys Val 
        35                  40                  45              


Gly Tyr Ile Leu Ala Ile Lys Met Asn Gly Phe Thr Cys Thr Gly Val 
    50                  55                  60                  


Val Thr Glu Ala Glu Thr Tyr Thr Asn Phe Val Gly Tyr Val Thr Thr 
65                  70                  75                  80  


Thr Phe Lys Arg Lys His Phe Arg Pro Thr Pro Asp Ala Cys Arg Ala 
                85                  90                  95      


Ala Tyr Asn Trp Lys Met Ala Gly Asp Pro Arg Tyr Glu Glu Ser Leu 
            100                 105                 110         


His Asn Pro Tyr Pro Asp Tyr Arg Trp Leu Arg Thr Val Lys Thr Thr 
        115                 120                 125             


Lys Glu Ser Leu Val Ile Ile Ser Pro Ser Val Ala Asp Leu Asp Pro 
    130                 135                 140                 


Tyr Asp Arg Ser Leu His Ser Arg Val Phe Pro Ser Gly Lys Cys Ser 
145                 150                 155                 160 


Gly Val Ala Val Ser Ser Thr Tyr Cys Ser Thr Asn His Asp Tyr Thr 
                165                 170                 175     


Ile Trp Met Pro Glu Asn Pro Arg Leu Gly Met Ser Cys Asp Ile Phe 
            180                 185                 190         


Thr Asn Ser Arg Gly Lys Arg Ala Ser Lys Gly Ser Glu Thr Cys Gly 
        195                 200                 205             


Phe Val Asp Glu Arg Gly Leu Tyr Lys Ser Leu Lys Gly Ala Cys Lys 
    210                 215                 220                 


Leu Lys Leu Cys Gly Val Leu Gly Leu Arg Leu Met Asp Gly Thr Trp 
225                 230                 235                 240 


Val Ala Met Gln Thr Ser Asn Glu Thr Lys Trp Cys Pro Pro Asp Gln 
                245                 250                 255     


Leu Val Asn Leu His Asp Phe Arg Ser Asp Glu Ile Glu His Leu Val 
            260                 265                 270         


Val Glu Glu Leu Val Arg Lys Arg Glu Glu Cys Leu Asp Ala Leu Glu 
        275                 280                 285             


Ser Ile Met Thr Thr Lys Ser Val Ser Phe Arg Arg Leu Ser His Leu 
    290                 295                 300                 


Arg Lys Leu Val Pro Gly Phe Gly Lys Ala Tyr Thr Ile Phe Asn Lys 
305                 310                 315                 320 


Thr Leu Met Glu Ala Asp Ala His Tyr Lys Ser Val Arg Thr Trp Asn 
                325                 330                 335     


Glu Ile Leu Pro Ser Lys Gly Cys Leu Arg Val Gly Gly Arg Cys His 
            340                 345                 350         


Pro His Val Asn Gly Val Phe Phe Asn Gly Ile Ile Leu Gly Pro Asp 
        355                 360                 365             


Gly Asn Val Leu Ile Pro Glu Met Gln Ser Ser Leu Leu Gln Gln His 
    370                 375                 380                 


Met Glu Leu Leu Glu Ser Ser Val Ile Pro Leu Val His Pro Leu Ala 
385                 390                 395                 400 


Asp Pro Ser Thr Val Phe Lys Asp Gly Asp Glu Ala Glu Asp Phe Val 
                405                 410                 415     


Glu Val His Leu Pro Asp Val His Asn Gln Val Ser Gly Val Asp Leu 
            420                 425                 430         


Gly Leu Pro Asn Trp Gly Lys Tyr 
        435                 440 


<210>  1156
<211>  21
<212>  PRT
<213>  Lyssavirus Rabies lyssavirus

<400>  1156

Val Leu Leu Ser Ala Gly Ala Leu Thr Ala Leu Met Leu Ile Ile Phe 
1               5                   10                  15      


Leu Met Thr Cys Cys 
            20      


<210>  1157
<211>  44
<212>  PRT
<213>  Lyssavirus Rabies lyssavirus

<400>  1157

Arg Arg Val Asn Arg Ser Glu Pro Thr Gln His Asn Leu Arg Gly Thr 
1               5                   10                  15      


Gly Arg Glu Val Ser Val Thr Pro Gln Ser Gly Lys Ile Ile Ser Ser 
            20                  25                  30          


Trp Glu Ser His Lys Ser Gly Gly Glu Thr Arg Leu 
        35                  40                  


<210>  1158
<211>  1236
<212>  PRT
<213>  Alphavirus Western equine encephalitis virus

<400>  1158

Met Phe Pro Tyr Pro Gln Leu Asn Phe Pro Pro Val Tyr Pro Thr Asn 
1               5                   10                  15      


Pro Met Ala Tyr Arg Asp Pro Asn Pro Pro Arg Cys Arg Trp Arg Pro 
            20                  25                  30          


Phe Arg Pro Pro Leu Ala Ala Gln Ile Glu Asp Leu Arg Arg Ser Ile 
        35                  40                  45              


Ala Asn Leu Thr Phe Lys Gln Arg Ser Pro Asn Pro Pro Pro Gly Pro 
    50                  55                  60                  


Pro Pro Lys Lys Lys Lys Ser Ala Pro Lys Pro Lys Pro Thr Gln Pro 
65                  70                  75                  80  


Lys Lys Lys Lys Gln Gln Ala Lys Lys Thr Lys Arg Lys Pro Lys Pro 
                85                  90                  95      


Gly Lys Arg Gln Arg Met Cys Met Lys Leu Glu Ser Asp Lys Thr Phe 
            100                 105                 110         


Pro Ile Met Leu Asn Gly Gln Val Asn Gly Tyr Ala Cys Val Val Gly 
        115                 120                 125             


Gly Arg Leu Met Lys Pro Leu His Val Glu Gly Lys Ile Asp Asn Glu 
    130                 135                 140                 


Gln Leu Ala Ala Val Lys Leu Lys Lys Ala Ser Met Tyr Asp Leu Glu 
145                 150                 155                 160 


Tyr Gly Asp Val Pro Gln Asn Met Lys Ser Asp Thr Leu Gln Tyr Thr 
                165                 170                 175     


Ser Asp Lys Pro Pro Gly Phe Tyr Asn Trp His His Gly Ala Val Gln 
            180                 185                 190         


Tyr Glu Asn Gly Arg Phe Thr Val Pro Arg Gly Val Gly Gly Lys Gly 
        195                 200                 205             


Asp Ser Gly Arg Pro Ile Leu Asp Asn Arg Gly Arg Val Val Ala Ile 
    210                 215                 220                 


Val Leu Gly Gly Ala Asn Glu Gly Thr Arg Thr Ala Leu Ser Val Val 
225                 230                 235                 240 


Thr Trp Asn Gln Lys Gly Val Thr Ile Lys Asp Thr Pro Glu Gly Ser 
                245                 250                 255     


Glu Pro Trp Ser Leu Val Thr Ala Leu Cys Val Leu Ser Asn Val Thr 
            260                 265                 270         


Phe Pro Cys Asp Lys Pro Pro Val Cys Tyr Ser Leu Ala Pro Glu Arg 
        275                 280                 285             


Thr Leu Asp Val Leu Glu Glu Asn Val Asp Asn Pro Asn Tyr Asp Thr 
    290                 295                 300                 


Leu Leu Glu Asn Val Leu Lys Cys Pro Ser Arg Arg Pro Lys Arg Ser 
305                 310                 315                 320 


Ile Thr Asp Asp Phe Thr Leu Thr Ser Pro Tyr Leu Gly Phe Cys Pro 
                325                 330                 335     


Tyr Cys Arg His Ser Ala Pro Cys Phe Ser Pro Ile Lys Ile Glu Asn 
            340                 345                 350         


Val Trp Asp Glu Ser Asp Asp Gly Ser Ile Arg Ile Gln Val Ser Ala 
        355                 360                 365             


Gln Phe Gly Tyr Asn Gln Ala Gly Thr Ala Asp Val Thr Lys Phe Arg 
    370                 375                 380                 


Tyr Met Ser Phe Asp His Asp His Asp Ile Lys Glu Asp Ser Met Asp 
385                 390                 395                 400 


Lys Ile Ala Ile Ser Thr Ser Gly Pro Cys Arg Arg Leu Gly His Lys 
                405                 410                 415     


Gly Tyr Phe Leu Leu Ala Gln Cys Pro Pro Gly Asp Ser Val Thr Val 
            420                 425                 430         


Ser Ile Thr Ser Gly Ala Ser Glu Asn Ser Cys Thr Val Glu Lys Lys 
        435                 440                 445             


Ile Arg Arg Lys Phe Val Gly Arg Glu Glu Tyr Leu Phe Pro Pro Val 
    450                 455                 460                 


His Gly Lys Leu Val Lys Cys His Val Tyr Asp His Leu Lys Glu Thr 
465                 470                 475                 480 


Ser Ala Gly Tyr Ile Thr Met His Arg Pro Gly Pro His Ala Tyr Lys 
                485                 490                 495     


Ser Tyr Leu Glu Glu Ala Ser Gly Glu Val Tyr Ile Lys Pro Pro Ser 
            500                 505                 510         


Gly Lys Asn Val Thr Tyr Glu Cys Lys Cys Gly Asp Tyr Ser Thr Gly 
        515                 520                 525             


Ile Val Ser Thr Arg Thr Lys Met Asn Gly Cys Thr Lys Ala Lys Gln 
    530                 535                 540                 


Cys Ile Ala Tyr Lys Ser Asp Gln Thr Lys Trp Val Phe Asn Ser Pro 
545                 550                 555                 560 


Asp Leu Ile Arg His Thr Asp His Ser Val Gln Gly Lys Leu His Ile 
                565                 570                 575     


Pro Phe Arg Leu Thr Pro Thr Val Cys Pro Val Pro Leu Ala His Thr 
            580                 585                 590         


Pro Thr Val Thr Lys Trp Phe Lys Gly Ile Thr Leu His Leu Thr Ala 
        595                 600                 605             


Thr Arg Pro Thr Leu Leu Thr Thr Arg Lys Leu Gly Leu Arg Ala Asp 
    610                 615                 620                 


Ala Thr Ala Glu Trp Ile Thr Gly Thr Thr Ser Arg Asn Phe Ser Val 
625                 630                 635                 640 


Gly Arg Glu Gly Leu Glu Tyr Val Trp Gly Asn His Glu Pro Val Arg 
                645                 650                 655     


Val Trp Ala Gln Glu Ser Ala Pro Gly Asp Pro His Gly Trp Pro His 
            660                 665                 670         


Glu Ile Ile Ile His Tyr Tyr His Arg His Pro Val Tyr Thr Val Ile 
        675                 680                 685             


Val Leu Cys Gly Val Ala Leu Ala Ile Leu Val Gly Thr Ala Ser Ser 
    690                 695                 700                 


Ala Ala Cys Ile Ala Lys Ala Arg Arg Asp Cys Leu Thr Pro Tyr Ala 
705                 710                 715                 720 


Leu Ala Pro Asn Ala Thr Val Pro Thr Ala Leu Ala Val Leu Cys Cys 
                725                 730                 735     


Ile Arg Pro Thr Asn Ala Glu Thr Phe Gly Glu Thr Leu Asn His Leu 
            740                 745                 750         


Trp Phe Asn Asn Gln Pro Phe Leu Trp Ala Gln Leu Cys Ile Pro Leu 
        755                 760                 765             


Ala Ala Leu Val Ile Leu Phe Arg Cys Phe Ser Cys Cys Met Pro Phe 
    770                 775                 780                 


Leu Leu Val Ala Gly Val Cys Leu Gly Lys Val Asp Ala Phe Glu His 
785                 790                 795                 800 


Ala Thr Thr Val Pro Asn Val Pro Gly Ile Pro Tyr Lys Ala Leu Val 
                805                 810                 815     


Glu Arg Ala Gly Tyr Ala Pro Leu Asn Leu Glu Ile Thr Val Val Ser 
            820                 825                 830         


Ser Glu Leu Thr Pro Ser Thr Asn Lys Glu Tyr Val Thr Cys Arg Phe 
        835                 840                 845             


His Thr Val Ile Pro Ser Pro Gln Val Lys Cys Cys Gly Ser Leu Glu 
    850                 855                 860                 


Cys Lys Ala Ser Ser Lys Ala Asp Tyr Thr Cys Arg Val Phe Gly Gly 
865                 870                 875                 880 


Val Tyr Pro Phe Met Trp Gly Gly Ala Gln Cys Phe Cys Asp Ser Glu 
                885                 890                 895     


Asn Thr Gln Leu Ser Glu Ala Tyr Val Glu Phe Ala Pro Asp Cys Thr 
            900                 905                 910         


Ile Asp His Ala Val Ala Leu Lys Val His Thr Ala Ala Leu Lys Val 
        915                 920                 925             


Gly Leu Arg Ile Val Tyr Gly Asn Thr Thr Ala His Leu Asp Thr Phe 
    930                 935                 940                 


Val Asn Gly Val Thr Pro Gly Ser Ser Arg Asp Leu Lys Val Ile Ala 
945                 950                 955                 960 


Gly Pro Ile Ser Ala Ala Phe Ser Pro Phe Asp His Lys Val Val Ile 
                965                 970                 975     


Arg Lys Gly Leu Val Tyr Asn Tyr Asp Phe Pro Glu Tyr Gly Ala Met 
            980                 985                 990         


Lys Pro Gly Ala Phe Gly Asp Ile  Gln Ala Ser Ser Leu  Asp Ala Thr 
        995                 1000                 1005             


Asp Ile  Val Ala Arg Thr Asp  Ile Arg Leu Leu Lys  Pro Ser Val 
    1010                 1015                 1020             


Lys Asn  Ile His Val Pro Tyr  Thr Gln Ala Val Ser  Gly Tyr Glu 
    1025                 1030                 1035             


Met Trp  Lys Asn Asn Ser Gly  Arg Pro Leu Gln Glu  Thr Ala Pro 
    1040                 1045                 1050             


Phe Gly  Cys Lys Ile Glu Val  Glu Pro Leu Arg Ala  Ser Asn Cys 
    1055                 1060                 1065             


Ala Tyr  Gly His Ile Pro Ile  Ser Ile Asp Ile Pro  Asp Ala Ala 
    1070                 1075                 1080             


Phe Val  Arg Ser Ser Glu Ser  Pro Thr Ile Leu Glu  Val Ser Cys 
    1085                 1090                 1095             


Thr Val  Ala Asp Cys Ile Tyr  Ser Ala Asp Phe Gly  Gly Ser Leu 
    1100                 1105                 1110             


Thr Leu  Gln Tyr Lys Ala Asp  Arg Glu Gly His Cys  Pro Val His 
    1115                 1120                 1125             


Ser His  Ser Thr Thr Ala Val  Leu Lys Glu Ala Thr  Thr His Val 
    1130                 1135                 1140             


Thr Ala  Val Gly Ser Ile Thr  Leu His Phe Ser Thr  Ser Ser Pro 
    1145                 1150                 1155             


Gln Ala  Asn Phe Ile Val Ser  Leu Cys Gly Lys Lys  Thr Thr Cys 
    1160                 1165                 1170             


Asn Ala  Glu Cys Lys Pro Pro  Ala Asp His Ile Ile  Gly Glu Pro 
    1175                 1180                 1185             


His Lys  Val Asp Gln Glu Phe  Gln Ala Ala Val Ser  Lys Thr Ser 
    1190                 1195                 1200             


Trp Asn  Trp Leu Leu Ala Leu  Phe Gly Gly Ala Ser  Ser Leu Ile 
    1205                 1210                 1215             


Val Val  Gly Leu Ile Val Leu  Val Cys Ser Ser Met  Leu Ile Asn 
    1220                 1225                 1230             


Thr Arg  Arg 
    1235     


<210>  1159
<211>  428
<212>  PRT
<213>  Alphavirus Western equine encephalitis virus

<400>  1159

Ser Leu Val Thr Ala Leu Cys Val Leu Ser Asn Val Thr Phe Pro Cys 
1               5                   10                  15      


Asp Lys Pro Pro Val Cys Tyr Ser Leu Ala Pro Glu Arg Thr Leu Asp 
            20                  25                  30          


Val Leu Glu Glu Asn Val Asp Asn Pro Asn Tyr Asp Thr Leu Leu Glu 
        35                  40                  45              


Asn Val Leu Lys Cys Pro Ser Arg Arg Pro Lys Arg Ser Ile Thr Asp 
    50                  55                  60                  


Asp Phe Thr Leu Thr Ser Pro Tyr Leu Gly Phe Cys Pro Tyr Cys Arg 
65                  70                  75                  80  


His Ser Ala Pro Cys Phe Ser Pro Ile Lys Ile Glu Asn Val Trp Asp 
                85                  90                  95      


Glu Ser Asp Asp Gly Ser Ile Arg Ile Gln Val Ser Ala Gln Phe Gly 
            100                 105                 110         


Tyr Asn Gln Ala Gly Thr Ala Asp Val Thr Lys Phe Arg Tyr Met Ser 
        115                 120                 125             


Phe Asp His Asp His Asp Ile Lys Glu Asp Ser Met Asp Lys Ile Ala 
    130                 135                 140                 


Ile Ser Thr Ser Gly Pro Cys Arg Arg Leu Gly His Lys Gly Tyr Phe 
145                 150                 155                 160 


Leu Leu Ala Gln Cys Pro Pro Gly Asp Ser Val Thr Val Ser Ile Thr 
                165                 170                 175     


Ser Gly Ala Ser Glu Asn Ser Cys Thr Val Glu Lys Lys Ile Arg Arg 
            180                 185                 190         


Lys Phe Val Gly Arg Glu Glu Tyr Leu Phe Pro Pro Val His Gly Lys 
        195                 200                 205             


Leu Val Lys Cys His Val Tyr Asp His Leu Lys Glu Thr Ser Ala Gly 
    210                 215                 220                 


Tyr Ile Thr Met His Arg Pro Gly Pro His Ala Tyr Lys Ser Tyr Leu 
225                 230                 235                 240 


Glu Glu Ala Ser Gly Glu Val Tyr Ile Lys Pro Pro Ser Gly Lys Asn 
                245                 250                 255     


Val Thr Tyr Glu Cys Lys Cys Gly Asp Tyr Ser Thr Gly Ile Val Ser 
            260                 265                 270         


Thr Arg Thr Lys Met Asn Gly Cys Thr Lys Ala Lys Gln Cys Ile Ala 
        275                 280                 285             


Tyr Lys Ser Asp Gln Thr Lys Trp Val Phe Asn Ser Pro Asp Leu Ile 
    290                 295                 300                 


Arg His Thr Asp His Ser Val Gln Gly Lys Leu His Ile Pro Phe Arg 
305                 310                 315                 320 


Leu Thr Pro Thr Val Cys Pro Val Pro Leu Ala His Thr Pro Thr Val 
                325                 330                 335     


Thr Lys Trp Phe Lys Gly Ile Thr Leu His Leu Thr Ala Thr Arg Pro 
            340                 345                 350         


Thr Leu Leu Thr Thr Arg Lys Leu Gly Leu Arg Ala Asp Ala Thr Ala 
        355                 360                 365             


Glu Trp Ile Thr Gly Thr Thr Ser Arg Asn Phe Ser Val Gly Arg Glu 
    370                 375                 380                 


Gly Leu Glu Tyr Val Trp Gly Asn His Glu Pro Val Arg Val Trp Ala 
385                 390                 395                 400 


Gln Glu Ser Ala Pro Gly Asp Pro His Gly Trp Pro His Glu Ile Ile 
                405                 410                 415     


Ile His Tyr Tyr His Arg His Pro Val Tyr Thr Val 
            420                 425             


<210>  1160
<211>  21
<212>  PRT
<213>  Alphavirus Western equine encephalitis virus

<400>  1160

Ile Val Leu Cys Gly Val Ala Leu Ala Ile Leu Val Gly Thr Ala Ser 
1               5                   10                  15      


Ser Ala Ala Cys Ile 
            20      


<210>  1161
<211>  34
<212>  PRT
<213>  Alphavirus Western equine encephalitis virus

<400>  1161

Ala Lys Ala Arg Arg Asp Cys Leu Thr Pro Tyr Ala Leu Ala Pro Asn 
1               5                   10                  15      


Ala Thr Val Pro Thr Ala Leu Ala Val Leu Cys Cys Ile Arg Pro Thr 
            20                  25                  30          


Asn Ala 
        


<210>  1162
<211>  25
<212>  PRT
<213>  Alphavirus Western equine encephalitis virus

<400>  1162

Glu Thr Phe Gly Glu Thr Leu Asn His Leu Trp Phe Asn Asn Gln Pro 
1               5                   10                  15      


Phe Leu Trp Ala Gln Leu Cys Ile Pro 
            20                  25  


<210>  1163
<211>  21
<212>  PRT
<213>  Alphavirus Western equine encephalitis virus

<400>  1163

Leu Ala Ala Leu Val Ile Leu Phe Arg Cys Phe Ser Cys Cys Met Pro 
1               5                   10                  15      


Phe Leu Leu Val Ala 
            20      


<210>  1164
<211>  21
<212>  PRT
<213>  Alphavirus Western equine encephalitis virus

<400>  1164

Gly Val Cys Leu Gly Lys Val Asp Ala Phe Glu His Ala Thr Thr Val 
1               5                   10                  15      


Pro Asn Val Pro Gly 
            20      


<210>  1165
<211>  396
<212>  PRT
<213>  Alphavirus Western equine encephalitis virus

<400>  1165

Ile Pro Tyr Lys Ala Leu Val Glu Arg Ala Gly Tyr Ala Pro Leu Asn 
1               5                   10                  15      


Leu Glu Ile Thr Val Val Ser Ser Glu Leu Thr Pro Ser Thr Asn Lys 
            20                  25                  30          


Glu Tyr Val Thr Cys Arg Phe His Thr Val Ile Pro Ser Pro Gln Val 
        35                  40                  45              


Lys Cys Cys Gly Ser Leu Glu Cys Lys Ala Ser Ser Lys Ala Asp Tyr 
    50                  55                  60                  


Thr Cys Arg Val Phe Gly Gly Val Tyr Pro Phe Met Trp Gly Gly Ala 
65                  70                  75                  80  


Gln Cys Phe Cys Asp Ser Glu Asn Thr Gln Leu Ser Glu Ala Tyr Val 
                85                  90                  95      


Glu Phe Ala Pro Asp Cys Thr Ile Asp His Ala Val Ala Leu Lys Val 
            100                 105                 110         


His Thr Ala Ala Leu Lys Val Gly Leu Arg Ile Val Tyr Gly Asn Thr 
        115                 120                 125             


Thr Ala His Leu Asp Thr Phe Val Asn Gly Val Thr Pro Gly Ser Ser 
    130                 135                 140                 


Arg Asp Leu Lys Val Ile Ala Gly Pro Ile Ser Ala Ala Phe Ser Pro 
145                 150                 155                 160 


Phe Asp His Lys Val Val Ile Arg Lys Gly Leu Val Tyr Asn Tyr Asp 
                165                 170                 175     


Phe Pro Glu Tyr Gly Ala Met Lys Pro Gly Ala Phe Gly Asp Ile Gln 
            180                 185                 190         


Ala Ser Ser Leu Asp Ala Thr Asp Ile Val Ala Arg Thr Asp Ile Arg 
        195                 200                 205             


Leu Leu Lys Pro Ser Val Lys Asn Ile His Val Pro Tyr Thr Gln Ala 
    210                 215                 220                 


Val Ser Gly Tyr Glu Met Trp Lys Asn Asn Ser Gly Arg Pro Leu Gln 
225                 230                 235                 240 


Glu Thr Ala Pro Phe Gly Cys Lys Ile Glu Val Glu Pro Leu Arg Ala 
                245                 250                 255     


Ser Asn Cys Ala Tyr Gly His Ile Pro Ile Ser Ile Asp Ile Pro Asp 
            260                 265                 270         


Ala Ala Phe Val Arg Ser Ser Glu Ser Pro Thr Ile Leu Glu Val Ser 
        275                 280                 285             


Cys Thr Val Ala Asp Cys Ile Tyr Ser Ala Asp Phe Gly Gly Ser Leu 
    290                 295                 300                 


Thr Leu Gln Tyr Lys Ala Asp Arg Glu Gly His Cys Pro Val His Ser 
305                 310                 315                 320 


His Ser Thr Thr Ala Val Leu Lys Glu Ala Thr Thr His Val Thr Ala 
                325                 330                 335     


Val Gly Ser Ile Thr Leu His Phe Ser Thr Ser Ser Pro Gln Ala Asn 
            340                 345                 350         


Phe Ile Val Ser Leu Cys Gly Lys Lys Thr Thr Cys Asn Ala Glu Cys 
        355                 360                 365             


Lys Pro Pro Ala Asp His Ile Ile Gly Glu Pro His Lys Val Asp Gln 
    370                 375                 380                 


Glu Phe Gln Ala Ala Val Ser Lys Thr Ser Trp Asn 
385                 390                 395     


<210>  1166
<211>  21
<212>  PRT
<213>  Alphavirus Western equine encephalitis virus

<400>  1166

Trp Leu Leu Ala Leu Phe Gly Gly Ala Ser Ser Leu Ile Val Val Gly 
1               5                   10                  15      


Leu Ile Val Leu Val 
            20      


<210>  1167
<211>  10
<212>  PRT
<213>  Alphavirus Western equine encephalitis virus

<400>  1167

Cys Ser Ser Met Leu Ile Asn Thr Arg Arg 
1               5                   10  


<210>  1168
<211>  617
<212>  PRT
<213>  Morbillivirus Measles morbillivirus

<400>  1168

Met Ser Pro Gln Arg Asp Arg Ile Asn Ala Phe Tyr Lys Asp Asn Pro 
1               5                   10                  15      


His Pro Lys Gly Ser Arg Ile Val Ile Asn Arg Glu His Leu Met Ile 
            20                  25                  30          


Asp Arg Pro Tyr Val Leu Leu Ala Val Leu Phe Val Met Phe Leu Ser 
        35                  40                  45              


Leu Ile Gly Leu Leu Ala Ile Ala Gly Ile Arg Leu His Arg Ala Ala 
    50                  55                  60                  


Ile Tyr Thr Ala Glu Ile His Lys Ser Leu Ser Thr Asn Leu Asp Val 
65                  70                  75                  80  


Thr Asn Ser Ile Glu His Gln Val Lys Asp Val Leu Thr Pro Leu Phe 
                85                  90                  95      


Lys Ile Ile Gly Asp Glu Val Gly Leu Arg Thr Pro Gln Arg Phe Thr 
            100                 105                 110         


Asp Leu Val Lys Phe Ile Ser Asp Lys Ile Lys Phe Leu Asn Pro Asp 
        115                 120                 125             


Arg Glu Tyr Asp Phe Arg Asp Leu Thr Trp Cys Ile Asn Pro Pro Glu 
    130                 135                 140                 


Arg Ile Lys Leu Asp Tyr Asp Gln Tyr Cys Ala Asp Val Ala Ala Glu 
145                 150                 155                 160 


Glu Leu Met Asn Ala Leu Val Asn Ser Thr Leu Leu Glu Ala Arg Ala 
                165                 170                 175     


Thr Asn Gln Phe Leu Ala Val Ser Lys Gly Asn Cys Ser Gly Pro Thr 
            180                 185                 190         


Thr Ile Arg Gly Gln Phe Ser Asn Met Ser Leu Ser Leu Leu Asp Leu 
        195                 200                 205             


Tyr Leu Ser Arg Gly Tyr Asn Val Ser Ser Ile Val Thr Met Thr Ser 
    210                 215                 220                 


Gln Gly Met Tyr Gly Gly Thr Tyr Leu Val Gly Lys Pro Asn Leu Ser 
225                 230                 235                 240 


Ser Lys Gly Ser Glu Leu Ser Gln Leu Ser Met His Arg Val Phe Glu 
                245                 250                 255     


Val Gly Val Ile Arg Asn Pro Gly Leu Gly Ala Pro Val Phe His Met 
            260                 265                 270         


Thr Asn Tyr Phe Glu Gln Pro Val Ser Asn Asp Phe Ser Asn Cys Met 
        275                 280                 285             


Val Ala Leu Gly Glu Leu Lys Phe Ala Ala Leu Cys His Arg Glu Asp 
    290                 295                 300                 


Ser Ile Thr Ile Pro Tyr Gln Gly Ser Gly Lys Gly Val Ser Phe Gln 
305                 310                 315                 320 


Leu Val Lys Leu Gly Val Trp Lys Ser Pro Thr Asp Met Arg Ser Trp 
                325                 330                 335     


Val Pro Leu Ser Thr Asp Asp Pro Val Ile Asp Arg Leu Tyr Leu Ser 
            340                 345                 350         


Ser His Arg Gly Val Ile Ala Asp Asn Gln Ala Lys Trp Ala Val Pro 
        355                 360                 365             


Thr Thr Arg Thr Asp Asp Lys Leu Arg Met Glu Thr Cys Phe Gln Gln 
    370                 375                 380                 


Ala Cys Lys Gly Lys Asn Gln Ala Leu Cys Glu Asn Pro Glu Trp Ala 
385                 390                 395                 400 


Pro Leu Lys Asp Asn Arg Ile Pro Ser Tyr Gly Val Leu Ser Val Asn 
                405                 410                 415     


Leu Ser Leu Thr Val Glu Leu Lys Ile Lys Ile Ala Ser Gly Phe Gly 
            420                 425                 430         


Pro Leu Ile Thr His Gly Ser Gly Met Asp Leu Tyr Lys Thr Asn His 
        435                 440                 445             


Asn Asn Val Tyr Trp Leu Thr Ile Pro Pro Met Lys Asn Leu Ala Leu 
    450                 455                 460                 


Gly Val Ile Asn Thr Leu Glu Trp Ile Pro Arg Phe Lys Val Ser Pro 
465                 470                 475                 480 


Asn Leu Phe Thr Val Pro Ile Lys Glu Ala Gly Glu Asp Cys His Ala 
                485                 490                 495     


Pro Thr Tyr Leu Pro Ala Glu Val Asp Gly Asp Val Lys Leu Ser Ser 
            500                 505                 510         


Asn Leu Val Ile Leu Pro Gly Gln Asp Leu Gln Tyr Val Leu Ala Thr 
        515                 520                 525             


Tyr Asp Thr Ser Arg Val Glu His Ala Val Val Tyr Tyr Val Tyr Ser 
    530                 535                 540                 


Pro Ser Arg Ser Phe Ser Tyr Phe Tyr Pro Phe Arg Leu Pro Ile Lys 
545                 550                 555                 560 


Gly Val Pro Ile Glu Leu Gln Val Glu Cys Phe Thr Trp Asp Lys Lys 
                565                 570                 575     


Leu Trp Cys Arg His Phe Cys Val Leu Ala Asp Ser Glu Ser Gly Gly 
            580                 585                 590         


His Ile Thr His Ser Gly Met Val Gly Met Gly Val Ser Cys Thr Val 
        595                 600                 605             


Thr Arg Glu Asp Gly Thr Asn Arg Arg 
    610                 615         


<210>  1169
<211>  559
<212>  PRT
<213>  Morbillivirus Measles morbillivirus

<400>  1169

Arg Leu His Arg Ala Ala Ile Tyr Thr Ala Glu Ile His Lys Ser Leu 
1               5                   10                  15      


Ser Thr Asn Leu Asp Val Thr Asn Ser Ile Glu His Gln Val Lys Asp 
            20                  25                  30          


Val Leu Thr Pro Leu Phe Lys Ile Ile Gly Asp Glu Val Gly Leu Arg 
        35                  40                  45              


Thr Pro Gln Arg Phe Thr Asp Leu Val Lys Phe Ile Ser Asp Lys Ile 
    50                  55                  60                  


Lys Phe Leu Asn Pro Asp Arg Glu Tyr Asp Phe Arg Asp Leu Thr Trp 
65                  70                  75                  80  


Cys Ile Asn Pro Pro Glu Arg Ile Lys Leu Asp Tyr Asp Gln Tyr Cys 
                85                  90                  95      


Ala Asp Val Ala Ala Glu Glu Leu Met Asn Ala Leu Val Asn Ser Thr 
            100                 105                 110         


Leu Leu Glu Ala Arg Ala Thr Asn Gln Phe Leu Ala Val Ser Lys Gly 
        115                 120                 125             


Asn Cys Ser Gly Pro Thr Thr Ile Arg Gly Gln Phe Ser Asn Met Ser 
    130                 135                 140                 


Leu Ser Leu Leu Asp Leu Tyr Leu Ser Arg Gly Tyr Asn Val Ser Ser 
145                 150                 155                 160 


Ile Val Thr Met Thr Ser Gln Gly Met Tyr Gly Gly Thr Tyr Leu Val 
                165                 170                 175     


Gly Lys Pro Asn Leu Ser Ser Lys Gly Ser Glu Leu Ser Gln Leu Ser 
            180                 185                 190         


Met His Arg Val Phe Glu Val Gly Val Ile Arg Asn Pro Gly Leu Gly 
        195                 200                 205             


Ala Pro Val Phe His Met Thr Asn Tyr Phe Glu Gln Pro Val Ser Asn 
    210                 215                 220                 


Asp Phe Ser Asn Cys Met Val Ala Leu Gly Glu Leu Lys Phe Ala Ala 
225                 230                 235                 240 


Leu Cys His Arg Glu Asp Ser Ile Thr Ile Pro Tyr Gln Gly Ser Gly 
                245                 250                 255     


Lys Gly Val Ser Phe Gln Leu Val Lys Leu Gly Val Trp Lys Ser Pro 
            260                 265                 270         


Thr Asp Met Arg Ser Trp Val Pro Leu Ser Thr Asp Asp Pro Val Ile 
        275                 280                 285             


Asp Arg Leu Tyr Leu Ser Ser His Arg Gly Val Ile Ala Asp Asn Gln 
    290                 295                 300                 


Ala Lys Trp Ala Val Pro Thr Thr Arg Thr Asp Asp Lys Leu Arg Met 
305                 310                 315                 320 


Glu Thr Cys Phe Gln Gln Ala Cys Lys Gly Lys Asn Gln Ala Leu Cys 
                325                 330                 335     


Glu Asn Pro Glu Trp Ala Pro Leu Lys Asp Asn Arg Ile Pro Ser Tyr 
            340                 345                 350         


Gly Val Leu Ser Val Asn Leu Ser Leu Thr Val Glu Leu Lys Ile Lys 
        355                 360                 365             


Ile Ala Ser Gly Phe Gly Pro Leu Ile Thr His Gly Ser Gly Met Asp 
    370                 375                 380                 


Leu Tyr Lys Thr Asn His Asn Asn Val Tyr Trp Leu Thr Ile Pro Pro 
385                 390                 395                 400 


Met Lys Asn Leu Ala Leu Gly Val Ile Asn Thr Leu Glu Trp Ile Pro 
                405                 410                 415     


Arg Phe Lys Val Ser Pro Asn Leu Phe Thr Val Pro Ile Lys Glu Ala 
            420                 425                 430         


Gly Glu Asp Cys His Ala Pro Thr Tyr Leu Pro Ala Glu Val Asp Gly 
        435                 440                 445             


Asp Val Lys Leu Ser Ser Asn Leu Val Ile Leu Pro Gly Gln Asp Leu 
    450                 455                 460                 


Gln Tyr Val Leu Ala Thr Tyr Asp Thr Ser Arg Val Glu His Ala Val 
465                 470                 475                 480 


Val Tyr Tyr Val Tyr Ser Pro Ser Arg Ser Phe Ser Tyr Phe Tyr Pro 
                485                 490                 495     


Phe Arg Leu Pro Ile Lys Gly Val Pro Ile Glu Leu Gln Val Glu Cys 
            500                 505                 510         


Phe Thr Trp Asp Lys Lys Leu Trp Cys Arg His Phe Cys Val Leu Ala 
        515                 520                 525             


Asp Ser Glu Ser Gly Gly His Ile Thr His Ser Gly Met Val Gly Met 
    530                 535                 540                 


Gly Val Ser Cys Thr Val Thr Arg Glu Asp Gly Thr Asn Arg Arg 
545                 550                 555                 


<210>  1170
<211>  21
<212>  PRT
<213>  Morbillivirus Measles morbillivirus

<400>  1170

Leu Leu Ala Val Leu Phe Val Met Phe Leu Ser Leu Ile Gly Leu Leu 
1               5                   10                  15      


Ala Ile Ala Gly Ile 
            20      


<210>  1171
<211>  37
<212>  PRT
<213>  Morbillivirus Measles morbillivirus

<400>  1171

Met Ser Pro Gln Arg Asp Arg Ile Asn Ala Phe Tyr Lys Asp Asn Pro 
1               5                   10                  15      


His Pro Lys Gly Ser Arg Ile Val Ile Asn Arg Glu His Leu Met Ile 
            20                  25                  30          


Asp Arg Pro Tyr Val 
        35          


<210>  1172
<211>  550
<212>  PRT
<213>  Morbillivirus Measles morbillivirus

<400>  1172

Met Gly Leu Lys Val Asn Val Ser Ala Ile Phe Met Ala Val Leu Leu 
1               5                   10                  15      


Thr Leu Gln Thr Pro Thr Gly Gln Ile His Trp Gly Asn Leu Ser Lys 
            20                  25                  30          


Ile Gly Val Val Gly Ile Gly Ser Ala Ser Tyr Lys Val Met Thr Arg 
        35                  40                  45              


Ser Ser His Gln Ser Leu Val Ile Lys Leu Met Pro Asn Ile Thr Leu 
    50                  55                  60                  


Leu Asn Asn Cys Thr Arg Val Glu Ile Ala Glu Tyr Arg Arg Leu Leu 
65                  70                  75                  80  


Arg Thr Val Leu Glu Pro Ile Arg Asp Ala Leu Asn Ala Met Thr Gln 
                85                  90                  95      


Asn Ile Arg Pro Val Gln Ser Val Ala Ser Ser Arg Arg His Lys Arg 
            100                 105                 110         


Phe Ala Gly Val Val Leu Ala Gly Ala Ala Leu Gly Val Ala Thr Ala 
        115                 120                 125             


Ala Gln Ile Thr Ala Gly Ile Ala Leu His Gln Ser Met Leu Asn Ser 
    130                 135                 140                 


Gln Ala Ile Asp Asn Leu Arg Ala Ser Leu Glu Thr Thr Asn Gln Ala 
145                 150                 155                 160 


Ile Glu Ala Ile Arg Gln Ala Gly Gln Glu Met Ile Leu Ala Val Gln 
                165                 170                 175     


Gly Val Gln Asp Tyr Ile Asn Asn Glu Leu Ile Pro Ser Met Asn Gln 
            180                 185                 190         


Leu Ser Cys Asp Leu Ile Gly Gln Lys Leu Gly Leu Lys Leu Leu Arg 
        195                 200                 205             


Tyr Tyr Thr Glu Ile Leu Ser Leu Phe Gly Pro Ser Leu Arg Asp Pro 
    210                 215                 220                 


Ile Ser Ala Glu Ile Ser Ile Gln Ala Leu Ser Tyr Ala Leu Gly Gly 
225                 230                 235                 240 


Asp Ile Asn Lys Val Leu Glu Lys Leu Gly Tyr Ser Gly Gly Asp Leu 
                245                 250                 255     


Leu Gly Ile Leu Glu Ser Arg Gly Ile Lys Ala Arg Ile Thr His Val 
            260                 265                 270         


Asp Thr Glu Ser Tyr Phe Ile Val Leu Ser Ile Ala Tyr Pro Thr Leu 
        275                 280                 285             


Ser Glu Ile Lys Gly Val Ile Val His Arg Leu Glu Gly Val Ser Tyr 
    290                 295                 300                 


Asn Ile Gly Ser Gln Glu Trp Tyr Thr Thr Val Pro Lys Tyr Val Ala 
305                 310                 315                 320 


Thr Gln Gly Tyr Leu Ile Ser Asn Phe Asp Glu Ser Ser Cys Thr Phe 
                325                 330                 335     


Met Pro Glu Gly Thr Val Cys Ser Gln Asn Ala Leu Tyr Pro Met Ser 
            340                 345                 350         


Pro Leu Leu Gln Glu Cys Leu Arg Gly Ser Thr Lys Ser Cys Ala Arg 
        355                 360                 365             


Thr Leu Val Ser Gly Ser Phe Gly Asn Arg Phe Ile Leu Ser Gln Gly 
    370                 375                 380                 


Asn Leu Ile Ala Asn Cys Ala Ser Ile Leu Cys Lys Cys Tyr Thr Thr 
385                 390                 395                 400 


Gly Thr Ile Ile Asn Gln Asp Pro Asp Lys Ile Leu Thr Tyr Ile Ala 
                405                 410                 415     


Ala Asp His Cys Pro Val Val Glu Val Asn Gly Val Thr Ile Gln Val 
            420                 425                 430         


Gly Ser Arg Arg Tyr Pro Asp Ala Val Tyr Leu His Arg Ile Asp Leu 
        435                 440                 445             


Gly Pro Pro Ile Ser Leu Glu Arg Leu Asp Val Gly Thr Asn Leu Gly 
    450                 455                 460                 


Asn Ala Ile Ala Lys Leu Glu Asp Ala Lys Glu Leu Leu Glu Ser Ser 
465                 470                 475                 480 


Asp Gln Ile Leu Arg Ser Met Lys Gly Leu Ser Ser Thr Ser Ile Val 
                485                 490                 495     


Tyr Ile Leu Ile Ala Val Cys Leu Gly Gly Leu Ile Gly Ile Pro Ala 
            500                 505                 510         


Leu Ile Cys Cys Cys Arg Gly Arg Cys Asn Lys Lys Gly Glu Gln Val 
        515                 520                 525             


Gly Met Ser Arg Pro Gly Leu Lys Pro Asp Leu Thr Gly Thr Ser Lys 
    530                 535                 540                 


Ser Tyr Val Arg Ser Leu 
545                 550 


<210>  1173
<211>  471
<212>  PRT
<213>  Morbillivirus Measles morbillivirus

<400>  1173

Gln Ile His Trp Gly Asn Leu Ser Lys Ile Gly Val Val Gly Ile Gly 
1               5                   10                  15      


Ser Ala Ser Tyr Lys Val Met Thr Arg Ser Ser His Gln Ser Leu Val 
            20                  25                  30          


Ile Lys Leu Met Pro Asn Ile Thr Leu Leu Asn Asn Cys Thr Arg Val 
        35                  40                  45              


Glu Ile Ala Glu Tyr Arg Arg Leu Leu Arg Thr Val Leu Glu Pro Ile 
    50                  55                  60                  


Arg Asp Ala Leu Asn Ala Met Thr Gln Asn Ile Arg Pro Val Gln Ser 
65                  70                  75                  80  


Val Ala Ser Ser Arg Arg His Lys Arg Phe Ala Gly Val Val Leu Ala 
                85                  90                  95      


Gly Ala Ala Leu Gly Val Ala Thr Ala Ala Gln Ile Thr Ala Gly Ile 
            100                 105                 110         


Ala Leu His Gln Ser Met Leu Asn Ser Gln Ala Ile Asp Asn Leu Arg 
        115                 120                 125             


Ala Ser Leu Glu Thr Thr Asn Gln Ala Ile Glu Ala Ile Arg Gln Ala 
    130                 135                 140                 


Gly Gln Glu Met Ile Leu Ala Val Gln Gly Val Gln Asp Tyr Ile Asn 
145                 150                 155                 160 


Asn Glu Leu Ile Pro Ser Met Asn Gln Leu Ser Cys Asp Leu Ile Gly 
                165                 170                 175     


Gln Lys Leu Gly Leu Lys Leu Leu Arg Tyr Tyr Thr Glu Ile Leu Ser 
            180                 185                 190         


Leu Phe Gly Pro Ser Leu Arg Asp Pro Ile Ser Ala Glu Ile Ser Ile 
        195                 200                 205             


Gln Ala Leu Ser Tyr Ala Leu Gly Gly Asp Ile Asn Lys Val Leu Glu 
    210                 215                 220                 


Lys Leu Gly Tyr Ser Gly Gly Asp Leu Leu Gly Ile Leu Glu Ser Arg 
225                 230                 235                 240 


Gly Ile Lys Ala Arg Ile Thr His Val Asp Thr Glu Ser Tyr Phe Ile 
                245                 250                 255     


Val Leu Ser Ile Ala Tyr Pro Thr Leu Ser Glu Ile Lys Gly Val Ile 
            260                 265                 270         


Val His Arg Leu Glu Gly Val Ser Tyr Asn Ile Gly Ser Gln Glu Trp 
        275                 280                 285             


Tyr Thr Thr Val Pro Lys Tyr Val Ala Thr Gln Gly Tyr Leu Ile Ser 
    290                 295                 300                 


Asn Phe Asp Glu Ser Ser Cys Thr Phe Met Pro Glu Gly Thr Val Cys 
305                 310                 315                 320 


Ser Gln Asn Ala Leu Tyr Pro Met Ser Pro Leu Leu Gln Glu Cys Leu 
                325                 330                 335     


Arg Gly Ser Thr Lys Ser Cys Ala Arg Thr Leu Val Ser Gly Ser Phe 
            340                 345                 350         


Gly Asn Arg Phe Ile Leu Ser Gln Gly Asn Leu Ile Ala Asn Cys Ala 
        355                 360                 365             


Ser Ile Leu Cys Lys Cys Tyr Thr Thr Gly Thr Ile Ile Asn Gln Asp 
    370                 375                 380                 


Pro Asp Lys Ile Leu Thr Tyr Ile Ala Ala Asp His Cys Pro Val Val 
385                 390                 395                 400 


Glu Val Asn Gly Val Thr Ile Gln Val Gly Ser Arg Arg Tyr Pro Asp 
                405                 410                 415     


Ala Val Tyr Leu His Arg Ile Asp Leu Gly Pro Pro Ile Ser Leu Glu 
            420                 425                 430         


Arg Leu Asp Val Gly Thr Asn Leu Gly Asn Ala Ile Ala Lys Leu Glu 
        435                 440                 445             


Asp Ala Lys Glu Leu Leu Glu Ser Ser Asp Gln Ile Leu Arg Ser Met 
    450                 455                 460                 


Lys Gly Leu Ser Ser Thr Ser 
465                 470     


<210>  1174
<211>  21
<212>  PRT
<213>  Morbillivirus Measles morbillivirus

<400>  1174

Ile Val Tyr Ile Leu Ile Ala Val Cys Leu Gly Gly Leu Ile Gly Ile 
1               5                   10                  15      


Pro Ala Leu Ile Cys 
            20      


<210>  1175
<211>  35
<212>  PRT
<213>  Morbillivirus Measles morbillivirus

<400>  1175

Cys Cys Arg Gly Arg Cys Asn Lys Lys Gly Glu Gln Val Gly Met Ser 
1               5                   10                  15      


Arg Pro Gly Leu Lys Pro Asp Leu Thr Gly Thr Ser Lys Ser Tyr Val 
            20                  25                  30          


Arg Ser Leu 
        35  


<210>  1176
<211>  130
<212>  DNA
<213>  ArtSeq 	AAV ITR

<400>  1176
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct                                                             130


<210>  1177
<211>  141
<212>  DNA
<213>  ArtSeq 	AAV ITR

<400>  1177
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg       60

ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc      120

gagcgcgcag ctgcctgcag g                                                141


