                         SEQUENCE LISTING

<110>  Soret, Rodolphe
       Pilon, Nicolas
 
<120>  COMBINATION THERAPY FOR THE TREATMENT OF ENTERIC NEUROPATHIES

<130>  G12810-00827

<150>  US 63/202,549
<151>  2021-06-16

<160>  2     

<170>  PatentIn version 3.5

<210>  1
<211>  211
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SIGNAL
<222>  (1)..(19)

<220>
<221>  PROPEP
<222>  (20)..(75)

<220>
<221>  mat_peptide
<222>  (78)..(211)

<400>  1

Met Lys Leu Trp Asp Val Val Ala Val Cys Leu Val Leu Leu His Thr 
        -75                 -70                 -65             


Ala Ser Ala Phe Pro Leu Pro Ala Gly Lys Arg Pro Pro Glu Ala Pro 
    -60                 -55                 -50                 


Ala Glu Asp Arg Ser Leu Gly Arg Arg Arg Ala Pro Phe Ala Leu Ser 
-45                 -40                 -35                 -30 


Ser Asp Ser Asn Met Pro Glu Asp Tyr Pro Asp Gln Phe Asp Asp Val 
                -25                 -20                 -15     


Met Asp Phe Ile Gln Ala Thr Ile Lys Arg Leu Lys Arg Ser Pro Asp 
            -10                 -5              -1  1           


Lys Gln Met Ala Val Leu Pro Arg Arg Glu Arg Asn Arg Gln Ala Ala 
    5                   10                  15                  


Ala Ala Asn Pro Glu Asn Ser Arg Gly Lys Gly Arg Arg Gly Gln Arg 
20                  25                  30                  35  


Gly Lys Asn Arg Gly Cys Val Leu Thr Ala Ile His Leu Asn Val Thr 
                40                  45                  50      


Asp Leu Gly Leu Gly Tyr Glu Thr Lys Glu Glu Leu Ile Phe Arg Tyr 
            55                  60                  65          


Cys Ser Gly Ser Cys Asp Ala Ala Glu Thr Thr Tyr Asp Lys Ile Leu 
        70                  75                  80              


Lys Asn Leu Ser Arg Asn Arg Arg Leu Val Ser Asp Lys Val Gly Gln 
    85                  90                  95                  


Ala Cys Cys Arg Pro Ile Ala Phe Asp Asp Asp Leu Ser Phe Leu Asp 
100                 105                 110                 115 


Asp Asn Leu Val Tyr His Ile Leu Arg Lys His Ser Ala Lys Arg Cys 
                120                 125                 130     


Gly Cys Ile 
            


<210>  2
<211>  4171
<212>  DNA
<213>  Homo sapiens

<400>  2
agcctgcgct cctggcgccc tcatgtcttc acgggactcc ccgcgccggt tgacgtggtg       60

tctcgttcgg atctccaggc aagacctcag ctccggcagc agcatcagac aaaccagtct      120

cgtgctccca ggcagtgcgc ccagaggagg cgcagagcgc ggcagctgcc gctgagccgc      180

ccgcagcgcc ccgggcccgc gcagccccag ccaagagcgc gacgcgcgca gccctgtcag      240

ccccccaccc aaagcagcgg cggctgctcg gacctcggct tctgggggtg cgggggcccg      300

gcgggagagt tgccggcagc cctcgccctg ttggcggcgg cggcggcggg agtcttggcc      360

gccgcctcca gcgcgccctt gctgccccgc gcgaccccag gattgcgaac tcttgcccct      420

gacctgttgg gcggggctcc gcgctccagc catcagcccg gatgggtctc ctggctggga      480

cttggggcac ctggagttaa tgtccaacct agggtctgcg gagacccgat ccgaggtgcc      540

gccgccggac gggactttaa gatgaagtta tgggatgtcg tggctgtctg cctggtgctg      600

ctccacaccg cgtccgcctt cccgctgccc gccggtaaga ggcctcccga ggcgcccgcc      660

gaagaccgct ccctcggccg ccgccgcgcg cccttcgcgc tgagcagtga ctcaaatatg      720

ccagaggatt atcctgatca gttcgatgat gtcatggatt ttattcaagc caccattaaa      780

agactgaaaa ggtcaccaga taaacaaatg gcagtgcttc ctagaagaga gcggaatcgg      840

caggctgcag ctgccaaccc agagaattcc agaggaaaag gtcggagagg ccagaggggc      900

aaaaaccggg gttgtgtctt aactgcaata catttaaatg tcactgactt gggtctgggc      960

tatgaaacca aggaggaact gatttttagg tactgcagcg gctcttgcga tgcagctgag     1020

acaacgtacg acaaaatatt gaaaaactta tccagaaata gaaggctggt gagtgacaaa     1080

gtagggcagg catgttgcag acccatcgcc tttgatgatg acctgtcgtt tttagatgat     1140

aacctggttt accatattct aagaaagcat tccgctaaaa ggtgtggatg tatctgactc     1200

cggctccaga gactgctgtg tattgcattc ctgctacagt gcaaagaaag ggaccaaggt     1260

tcccaggaaa tgtttgccca gaatggaaga tgaggaccaa ggaggcggag gaggaggaag     1320

aagaagagga ggaggaggag gaggaggagg aggaggagga aggcagccat catgggagcc     1380

tggtagaggg agatccagct acagacaact ggacaggaga gagagaaaac agccctctgg     1440

attctccagg atggcagccg atgtcactag aagctcaggg ctgatgttcc tggttggcta     1500

ttgccaccat ttcagctgat acagtccacc atcactgatt accggcgcgg ttgcggtgga     1560

tgcacttgaa ccaaaccagt gtatctcctg tgatttgttt tcatgtgtcc gaagacacca     1620

gggaaacaga gatcctggtg ttgttccttg ttattacgtt ttactgctga aagtaagagg     1680

tttatttttc tgtcactcag tggagacata ccctggaaag gagaggggaa aaaaaaagca     1740

aagatacaag agataatcac ctttgcattt gaaagttgag gcccgaggtt tactacaacc     1800

agcatttttg ccaacggttg gtgattgatt tccatcacgg tgtgtggggt gggaagaagt     1860

tggctaggaa ccaaaaaggc tgtgctcatg attaaacaca aacctgaagg tatttccttt     1920

atgtccttgg aaacaggaaa cgagttgtgg ttttcgccag cattcttgta ggagagaatc     1980

ggggaaggcc ccgaactgcc cccgggcagg gagagcccct caggcctgtt ggtttacaga     2040

gagacagatg ttacataacc agctccgttg atgcgtggtc accagtgacc agagaagcta     2100

ctcgatgcaa tgcatctgtt tcagatacag aaatatagag aagatattta ttgaaattta     2160

agttattgtt atttattacc gttcactaat gaatttctct tttttccctt atttattaaa     2220

gtttcttttc aaaggtgcca aagtatatgt gctcgcaaaa tgcaaagaaa ggtgacaaaa     2280

ggaaatttga attgggaaca agggtccatg cttttcaaag tattaaaaag ttttttgcca     2340

ggcaaaaatc acttacttta cctttttaag aaaatttgtc attaattttc cccagatttc     2400

agcatttttc ccaattttta tttgtggagc atctcaggca agcccccttt cctggagcag     2460

cgtgcagaga ccactggcac ttgactttat ttcttccttg ctccattgct gaacagaaat     2520

gtcgtgggct ccacttcctg ttgtctttaa gctcttagtc ccctccacgt atacctatct     2580

gtactatgca taaccatatg tagaaaaggt tcagttcctt ttagtaggta gtcctggatt     2640

taatgctgac ctaaaagtaa tgtcgacaat gctgtcaggt agctgccgtt ctaccgactc     2700

cctccatccc tgcccaccca ctgccctccc gagaatatgc tggctgccca gtgcagcccg     2760

ggagacacag gggccttcca gaggtagggt ctaccaggtc ctgtacaacc cctgggctgt     2820

caccgggggt caacagctgc tgctcctata tacccaaaca cctgacagct ccctggggag     2880

cagatggctg agaagggtgc tgaggaagcc atattgggac cagccacagc cacacacatg     2940

gagcctcata cttaggagcg tgctgccttt aaatgaaggt ggtcggggcc agtgcagcgg     3000

ctcacaccca taatcccaac actttggaaa gccaaggtgg gaggatctct tgaacccagg     3060

agtttgagac cagcttgggc aacataggga gaccctgtct ctacagaaac tttaaaaatt     3120

aggcaggcat gatggtgcac acctgtggtc ccagctactc aagaggctga aggaggatca     3180

cttgagtcca gaaggtcgag gctgcagtga gctgtgatca tgccactgca ctccagccta     3240

agtgacagtg cggtaccctg tctcaaaaaa aaaaaaaaaa aaaaaaagag gttggagcag     3300

gaggaagcat aggggcggga acagccacct cctccatgcc ctagattgtg aatttatcgg     3360

gcagccaaca catgtatgac acactaggcc ctgtattaca gcttgttacg catttcataa     3420

aagggatttt cattaaggag ataatctatt actacctacc ttagtggcta ctagtataaa     3480

actatgacag atttagcaat taaatgaaat actggcctcc atcaaataat catagtaaca     3540

agaagcagca gttaccagac atctgatccc cttcccccaa aatacccaaa ttcttcatgg     3600

ttctgccctt ctctgtcctt tctgctcccc ttgctcgcct gggaaatgga ggaaaggcct     3660

tccctctcac actgtcttgg gatcttgctg agaattcaga ctgctcgaaa cagtgacaaa     3720

ccccagccat ccagtcattc gtggagcaca atttggatgt ggccccaggg gcatctgtcc     3780

cattcagaga accttggcag tgcgatggcc actgttccca ggcttcaacc tcagtgaccc     3840

cccccaacaa ctccccatgg agagtccctg cccaaaaaag ctgtaggatc caaggggtgt     3900

caatagctcg ttcccggcat cacctacaca ccacaagcag gttttaatgg aagcaagttg     3960

ctccaccaaa tccacaaaag ggtaaagttt gtgatttttc tttatcattg cgatcaccat     4020

ctgataccgt aaggagtgca cttgtttgga agttctgact tctctgatct gtcttggtcg     4080

tttgtgttat aaaaccaaag ttctctacag actttatttt tgtacaatat cattttgtaa     4140

ctttttacaa ataaaaactc atttctattg c                                    4171


