                         SEQUENCE LISTING

<110>  BEIJING SINOTAU BIO-PHARMACEUTICALS TECHNOLOGY CO., LTD.
 
<120>  ANTI-HER3 ANTIBODY, ANTIBODY DRUG CONJUGATE CONTAINING THE SAME, AND USE THEREOF

<130>  XTBHER3-PCT2201

<160>  28    

<170>  PatentIn version 3.5

<210>  1
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide acid sequence of Variable region of murine 3F8 light 
       chain

<400>  1
atgatgtcct ctgctcagtt ccttggtctc ctgttgctct gttttcaagg taccagatgt       60

gatatccaga tgacacagac tacatcctcc ctgtctgcct ctctgggaga cagagtcacc      120

atcagttgca gggcaagtca ggacattagc aattatttaa actggtatca gcagaaacca      180

gatggcactt ttaaactcct gatctactac acatcaatat tacactcagg agtcccatca      240

aggttcagtg gcagtgggtc tggaacagat tattctctca ccattagcaa cctggagcaa      300

gaggatattg ccacttactt ttgccaacag ggtgatacgc ttcctcccac gttcggtgct      360

gggaccaagc tggagctgaa a                                                381


<210>  2
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of Variable region of murine 3F8 light chain

<400>  2

Met Met Ser Ser Ala Gln Phe Leu Gly Leu Leu Leu Leu Cys Phe Gln 
1               5                   10                  15      


Gly Thr Arg Cys Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp 
        35                  40                  45              


Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Phe 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Tyr Thr Ser Ile Leu His Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser 
                85                  90                  95      


Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asp 
            100                 105                 110         


Thr Leu Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
        115                 120                 125         


<210>  3
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader of Variable region of murine 3F8 light chain

<400>  3

Met Met Ser Ser Ala Gln Phe Leu Gly Leu Leu Leu Leu Cys Phe Gln 
1               5                   10                  15      


Gly Thr Arg Cys 
            20  


<210>  4
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LFR1 of Variable region of murine 3F8 light chain

<400>  4

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys 
            20              


<210>  5
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1 of Variable region of murine 3F8 light chain

<400>  5

Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  6
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LFR2 of Variable region of murine 3F8 light chain

<400>  6

Trp Tyr Gln Gln Lys Pro Asp Gly Thr Phe Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  7
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L2 of Variable region of murine 3F8 light chain

<400>  7

Tyr Thr Ser Ile Leu His Ser 
1               5           


<210>  8
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LFR3 of Variable region of murine 3F8 light chain

<400>  8

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser 
1               5                   10                  15      


Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys 
            20                  25                  30          


<210>  9
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L3 of Variable region of murine 3F8 light chain

<400>  9

Gln Gln Gly Asp Thr Leu Pro Pro Thr 
1               5                   


<210>  10
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LFR4 of Variable region of murine 3F8 light chain

<400>  10

Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg 
1               5                   10      


<210>  11
<211>  408
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of Variable region of murine 3F8 heavy chain

<400>  11
atgaaagtgt tgagtctgtt gtacctgttg acagccattc ctggtatcct gtctgatgta       60

caacttcagg agtcaggacc tggcctcgtg aaaccttctc agtctctgtc tctcacctgc      120

tctgtcactg gctactccat caccagtgct tattactgga actggatccg gcagtttcca      180

ggagacaaac tggaatggat gggctacata agctacgacg gtcgcaataa tttcaaccca      240

tctctcaaaa atcgaatctc catcactcgt gacacatcta agaaccagtt tttcctgaag      300

ttgaattctg tgacttctgg ggacacagct acatattact gtgcaagaga tggggattac      360

gactactttg actactgggg ccaaggcacc actctcacag tctcctca                   408


<210>  12
<211>  136
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of Variable region of murine 3F8 heavy chain

<400>  12

Met Lys Val Leu Ser Leu Leu Tyr Leu Leu Thr Ala Ile Pro Gly Ile 
1               5                   10                  15      


Leu Ser Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
            20                  25                  30          


Ser Gln Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr 
        35                  40                  45              


Ser Ala Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asp Lys Leu 
    50                  55                  60                  


Glu Trp Met Gly Tyr Ile Ser Tyr Asp Gly Arg Asn Asn Phe Asn Pro 
65                  70                  75                  80  


Ser Leu Lys Asn Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln 
                85                  90                  95      


Phe Phe Leu Lys Leu Asn Ser Val Thr Ser Gly Asp Thr Ala Thr Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Asp Gly Asp Tyr Asp Tyr Phe Asp Tyr Trp Gly Gln 
        115                 120                 125             


Gly Thr Thr Leu Thr Val Ser Ser 
    130                 135     


<210>  13
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader  of Variable region of murine 3F8 heavy chain

<400>  13

Met Lys Val Leu Ser Leu Leu Tyr Leu Leu Thr Ala Ile Pro Gly Ile 
1               5                   10                  15      


Leu Ser 
        


<210>  14
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HFR1 of Variable region of murine 3F8 heavy chain

<400>  14

Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr 
            20                  25                  30  


<210>  15
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1 of Variable region of murine 3F8 heavy chain

<400>  15

Ser Ala Tyr Tyr Trp Asn 
1               5       


<210>  16
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HFR2 of Variable region of murine 3F8 heavy chain

<400>  16

Trp Ile Arg Gln Phe Pro Gly Asp Lys Leu Glu Trp Met Gly 
1               5                   10                  


<210>  17
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2 of Variable region of murine 3F8 heavy chain

<400>  17

Tyr Ile Ser Tyr Asp Gly Arg Asn Asn Phe Asn Pro Ser Leu Lys Asn 
1               5                   10                  15      


<210>  18
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HFR3 of Variable region of murine 3F8 heavy chain

<400>  18

Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe Leu Lys 
1               5                   10                  15      


Leu Asn Ser Val Thr Ser Gly Asp Thr Ala Thr Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  19
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 of Variable region of murine 3F8 heavy chain

<400>  19

Asp Gly Asp Tyr Asp Tyr Phe Asp Tyr 
1               5                   


<210>  20
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HFR4 of Variable region of murine 3F8 heavy chain

<400>  20

Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
1               5                   10      


<210>  21
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of humanized 3F8-heavy chain of Clone 3

<400>  21

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile 
        35                  40                  45              


Thr Ser Ala Tyr Tyr Trp Asn Trp Ile Arg Gln Pro Phe Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Met Gly Tyr Ile Ser Tyr Asp Gly Arg Asn Asn Phe Asn 
65                  70                  75                  80  


Pro Ser Leu Lys Asn Arg Val Ser Ile Ser Arg Asp Thr Ser Lys Asn 
                85                  90                  95      


Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Thr 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Asp Gly Asp Tyr Asp Tyr Phe Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
145                 150                 155                 160 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        195                 200                 205             


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
    210                 215                 220                 


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
225                 230                 235                 240 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
                245                 250                 255     


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        275                 280                 285             


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    370                 375                 380                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            420                 425                 430         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 


Pro Gly Lys 
465         


<210>  22
<211>  1407
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide acid sequence of humanized 3F8-heavy chain of Clone 3

<400>  22
atgggctggt catgcattat tctgtttctg gtcgcaactg ctacaggcgt gcatagtcaa       60

gtgcagctgc aggagagcgg acctggcctc gtgaagccaa gcgagacact gtctctgaca      120

tgtaccgtgt ccggctacag catcacctcc gcctactact ggaactggat ccggcagcct      180

tttggcaagg gcctggaatg gatgggctac atcagctacg acggcagaaa caacttcaac      240

cccagcctga aaaatagagt gtccatctct cgggacacca gcaagaacca gttcagcctg      300

aagctgagca gcgtgacagc cgctgatacc gccacatact actgcgccag agacggagat      360

tatgactact tcgactactg gggccagggc accaccgtca ccgtgtctag cgccagcacc      420

aagggccctt ccgtgtttcc actggccccc tcctctaaat ccacatctgg cggcaccgcc      480

gccctgggct gtctggtgaa ggactacttc ccagagcctg tgacagtgtc ctggaactct      540

ggcgccctga catccggcgt gcacacattt ccagccgtgc tgcagagctc cggcctgtac      600

agcctgtcta gcgtggtgac agtgccctcc tctagcctgg gcacacagac ctatatctgc      660

aacgtgaatc acaagccaag caataccaag gtggacaaga aggtggagcc caagtcctgt      720

gataagacac acacctgccc cccttgtcct gctcccgagc tgctgggcgg ccctagcgtg      780

ttcctgtttc cacccaagcc taaggacacc ctgatgatct cccggacacc cgaggtgacc      840

tgcgtggtgg tggacgtgtc tcacgaggat cctgaggtga agttcaactg gtatgtggat      900

ggcgtggagg tgcacaatgc caagaccaag cccagagagg agcagtacaa ctctacatat      960

agggtggtga gcgtgctgac cgtgctgcac caggactggc tgaacggcaa ggagtataag     1020

tgcaaggtgt ccaataaggc cctgcccgcc cccatcgaga agacaatcag caaggccaag     1080

ggccagcctc gggagccaca ggtgtacacc ctgcctccat ccagagacga gctgacaaag     1140

aaccaggtgt ctctgacatg tctggtgaag ggcttctatc ctagcgatat cgccgtggag     1200

tgggagtcca atggccagcc agagaacaat tacaagacca caccccctgt gctggactcc     1260

gatggctcct tctttctgta ttccaagctg accgtggata agtctcggtg gcagcagggc     1320

aacgtgttca gctgttccgt gatgcacgaa gccctgcata atcactatac tcagaaatcc     1380

ctgtccctgt cacctggaaa gtgataa                                         1407


<210>  23
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of humanized 3F8-light chain of Clones 1-3

<400>  23

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile 
        35                  40                  45              


Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
    50                  55                  60                  


Leu Leu Ile Tyr Tyr Thr Ser Ile Leu His Ser Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asp Thr 
            100                 105                 110         


Leu Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr 
        115                 120                 125             


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
    130                 135                 140                 


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
145                 150                 155                 160 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
                165                 170                 175     


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
            180                 185                 190         


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
        195                 200                 205             


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
    210                 215                 220                 


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230             


<210>  24
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide acid sequence of humanized 3F8-light chain of Clones 1-3

<400>  24
atgggctggt catgtattat tctgtttctg gtcgcaactg ctacaggggt ccatagtgat       60

attcagatga cccagagccc cagcagcctg agcgccagcg tgggcgatag agtgaccatc      120

acatgtcggg cctctcagga catcagcaac tacctgaact ggtatcagca aaagcccggc      180

aaagccccta agctgctgat ctactacacc agcatcctgc acagcggagt gccatctaga      240

ttcagcggct ctggcagcgg caccgactac acatttacca tctcctccct ccagcctgag      300

gacatcgcta catacttctg ccagcagggc gacaccctgc ctcctacctt cggcggcgga      360

acaaagctgg aaatcaagag gacagtggcc gccccaagcg tgttcatctt tcccccttcc      420

gacgagcagc tgaagtctgg caccgccagc gtggtgtgcc tgctgaacaa cttctaccct      480

cgggaggcca aggtccagtg gaaggtggat aacgccctgc agtctggcaa tagccaggag      540

tccgtgaccg agcaggactc taaggatagc acatattccc tgtctagcac cctgacactg      600

agcaaggccg attacgagaa gcacaaggtg tatgcctgtg aagtcaccca tcaggggctg      660

tcatcacccg tcactaagtc attcaatcgc ggagaatgct gataa                      705


<210>  25
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of humanized 3F8-heavy chain of Clone 1

<400>  25

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile 
        35                  40                  45              


Thr Ser Ala Tyr Tyr Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Ile Gly Tyr Ile Ser Tyr Asp Gly Arg Asn Asn Phe Asn 
65                  70                  75                  80  


Pro Ser Leu Lys Asn Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn 
                85                  90                  95      


Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Asp Gly Asp Tyr Asp Tyr Phe Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
145                 150                 155                 160 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        195                 200                 205             


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
    210                 215                 220                 


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
225                 230                 235                 240 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
                245                 250                 255     


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        275                 280                 285             


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    370                 375                 380                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            420                 425                 430         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 


Pro Gly Lys 
465         


<210>  26
<211>  1407
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide acid sequence of humanized 3F8-heavy chain of Clone 1

<400>  26
atgggctggt catgcattat tctgtttctg gtcgcaactg ctacaggcgt gcatagtcaa       60

gtgcagctgc aggagagcgg ccctggactg gtgaagccta gcgagacact gtctctcacc      120

tgtaccgtgt ctggctacag catcacctcc gcctactact ggaactggat ccggcagcct      180

ccaggcaagg gcctggaatg gatcggctac atcagctacg acggcagaaa caacttcaac      240

cccagcctga aaaatagagt gaccatctct gtggacacca gcaagaacca gtttagcctg      300

aagctgagca gcgtgacagc cgctgatacc gccgtgtact actgcgccag agacggagat      360

tatgactact tcgactactg gggccagggc accacagtca cagtgtccag cgccagcacc      420

aagggccctt ccgtgtttcc actggccccc tcctctaaat ccacatctgg cggcaccgcc      480

gccctgggct gtctggtgaa ggactacttc ccagagcctg tgacagtgtc ctggaactct      540

ggcgccctga catccggcgt gcacacattt ccagccgtgc tgcagagctc cggcctgtac      600

agcctgtcta gcgtggtgac agtgccctcc tctagcctgg gcacacagac ctatatctgc      660

aacgtgaatc acaagccaag caataccaag gtggacaaga aggtggagcc caagtcctgt      720

gataagacac acacctgccc cccttgtcct gctcccgagc tgctgggcgg ccctagcgtg      780

ttcctgtttc cacccaagcc taaggacacc ctgatgatct cccggacacc cgaggtgacc      840

tgcgtggtgg tggacgtgtc tcacgaggat cctgaggtga agttcaactg gtatgtggat      900

ggcgtggagg tgcacaatgc caagaccaag cccagagagg agcagtacaa ctctacatat      960

agggtggtga gcgtgctgac cgtgctgcac caggactggc tgaacggcaa ggagtataag     1020

tgcaaggtgt ccaataaggc cctgcccgcc cccatcgaga agacaatcag caaggccaag     1080

ggccagcctc gggagccaca ggtgtacacc ctgcctccat ccagagacga gctgacaaag     1140

aaccaggtgt ctctgacatg tctggtgaag ggcttctatc ctagcgatat cgccgtggag     1200

tgggagtcca atggccagcc agagaacaat tacaagacca caccccctgt gctggactcc     1260

gatggctcct tctttctgta ttccaagctg accgtggata agtctcggtg gcagcagggc     1320

aacgtgttca gctgttccgt gatgcacgaa gccctgcata atcactatac tcagaaatcc     1380

ctgtccctgt cacctggaaa gtgataa                                         1407


<210>  27
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of humanized 3F8-heavy chain of Clone 2

<400>  27

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile 
        35                  40                  45              


Thr Ser Ala Tyr Tyr Trp Asn Trp Ile Arg Gln Pro Phe Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Met Gly Tyr Ile Ser Tyr Asp Gly Arg Asn Asn Phe Asn 
65                  70                  75                  80  


Pro Ser Leu Lys Asn Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn 
                85                  90                  95      


Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Asp Gly Asp Tyr Asp Tyr Phe Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
145                 150                 155                 160 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        195                 200                 205             


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
    210                 215                 220                 


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
225                 230                 235                 240 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
                245                 250                 255     


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        275                 280                 285             


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    370                 375                 380                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            420                 425                 430         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 


Pro Gly Lys 
465         


<210>  28
<211>  1407
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide acid sequence of humanized 3F8-heavy chain of Clone 2

<400>  28
atgggctggt catgcattat tctgtttctg gtcgcaactg ctacaggcgt gcatagtcaa       60

gtgcagctgc aggagagcgg ccccggcctg gtgaagccta gcgagacact gagcctcacc      120

tgtaccgtgt ccggctacag catcaccagc gcctactact ggaactggat ccggcagcct      180

tttggcaagg gcctggaatg gatgggctac atctcctacg acggcagaaa caacttcaac      240

ccatctctga aaaatagagt gaccatcagc cgggacacaa gcaagaacca gttcagcctg      300

aagctgtcta gcgtgacagc cgctgatacc gccgtgtact actgcgccag agacggagat      360

tatgactact tcgactactg gggacagggc accaccgtga cagtcagctc tgccagcacc      420

aagggccctt ccgtgtttcc actggccccc tcctctaaat ccacatctgg cggcaccgcc      480

gccctgggct gtctggtgaa ggactacttc ccagagcctg tgacagtgtc ctggaactct      540

ggcgccctga catccggcgt gcacacattt ccagccgtgc tgcagagctc cggcctgtac      600

agcctgtcta gcgtggtgac agtgccctcc tctagcctgg gcacacagac ctatatctgc      660

aacgtgaatc acaagccaag caataccaag gtggacaaga aggtggagcc caagtcctgt      720

gataagacac acacctgccc cccttgtcct gctcccgagc tgctgggcgg ccctagcgtg      780

ttcctgtttc cacccaagcc taaggacacc ctgatgatct cccggacacc cgaggtgacc      840

tgcgtggtgg tggacgtgtc tcacgaggat cctgaggtga agttcaactg gtatgtggat      900

ggcgtggagg tgcacaatgc caagaccaag cccagagagg agcagtacaa ctctacatat      960

agggtggtga gcgtgctgac cgtgctgcac caggactggc tgaacggcaa ggagtataag     1020

tgcaaggtgt ccaataaggc cctgcccgcc cccatcgaga agacaatcag caaggccaag     1080

ggccagcctc gggagccaca ggtgtacacc ctgcctccat ccagagacga gctgacaaag     1140

aaccaggtgt ctctgacatg tctggtgaag ggcttctatc ctagcgatat cgccgtggag     1200

tgggagtcca atggccagcc agagaacaat tacaagacca caccccctgt gctggactcc     1260

gatggctcct tctttctgta ttccaagctg accgtggata agtctcggtg gcagcagggc     1320

aacgtgttca gctgttccgt gatgcacgaa gccctgcata atcactatac tcagaaatcc     1380

ctgtccctgt cacctggaaa gtgataa                                         1407


