                         SEQUENCE LISTING

<110>  Ƽι˾
 ޹˾
 
<120>  CD22ȫԴ俹ԭƬμƱӦ

<130>  P08020220625

<150>  202110677437.9
<151>  2021-06-16

<160>  39    

<170>  PatentIn version 3.5

<210>  1
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1A scFv

<400>  1

Ser Val Ser Ser Asn Ser Ala Ala Trp Asn 
1               5                   10  


<210>  2
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2A scFv

<400>  2

Tyr Arg Ser Thr Trp Tyr Asn 
1               5           


<210>  3
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3A scFv

<400>  3

Ala Arg Asp Ala Ala Phe Gly Leu Asp Ala Leu Asp Ile 
1               5                   10              


<210>  4
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1 B scFv

<400>  4

Val Ser Ser Asn Ser Ala Ala Trp Asn 
1               5                   


<210>  5
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2B scFv

<400>  5

Tyr Arg Ser Lys Trp Tyr Asn 
1               5           


<210>  6
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3B scFv

<400>  6

Ala Arg Asp Ser Gly Gly Trp Leu Asp Pro 
1               5                   10  


<210>  7
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1A scFv

<400>  7

Gln Ser Ile Ser Ser Tyr 
1               5       


<210>  8
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L2A scFv

<400>  8

Ala Ala Ser 
1           


<210>  9
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L3A scFv

<400>  9

Gln Gln Ser Tyr Gly Thr Pro Leu Thr 
1               5                   


<210>  10
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1B scFv

<400>  10

Ser Ser Asn Ile Gly Met Asn Thr 
1               5               


<210>  11
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L2B scFv

<400>  11

Ser Asn His 
1           


<210>  12
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L3B scFv

<400>  12

Ala Ser Trp Asp Asp Ser Leu Asn Ala Pro Lys Tyr Val 
1               5                   10              


<210>  13
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHA scFv

<400>  13

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn 
            20                  25                  30          


Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Thr Trp Tyr Asn Asp Tyr Ala 
    50                  55                  60                  


Val Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp Thr Ser Ile Asn 
65                  70                  75                  80  


Gln Phe Ser Leu Gln Met Ser Tyr Val Thr Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Phe Cys Ala Arg Asp Ala Ala Phe Gly Leu Asp Ala Leu Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210>  14
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHB scFv

<400>  14

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn 
            20                  25                  30          


Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala 
    50                  55                  60                  


Val Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Asp Ser Gly Gly Trp Leu Asp Pro Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  15
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VLA scFv

<400>  15

Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Gly Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  16
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VLB scFv

<400>  16

Ser Tyr Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Met Asn 
            20                  25                  30          


Thr Val Asn Trp Tyr His Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ser Asn His Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Gly Asp Tyr Tyr Cys Ala Ser Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Ala Pro Lys Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110         


<210>  17
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A scFv

<400>  17

Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Gly Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln 
        115                 120                 125             


Ser Gly Pro Gly Leu Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys 
    130                 135                 140                 


Ala Ile Ser Gly Asp Ser Val Ser Ser Asn Ser Ala Ala Trp Asn Trp 
145                 150                 155                 160 


Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu Trp Leu Gly Arg Thr Tyr 
                165                 170                 175     


Tyr Arg Ser Thr Trp Tyr Asn Asp Tyr Ala Val Ser Val Lys Ser Arg 
            180                 185                 190         


Ile Thr Ile Asn Pro Asp Thr Ser Ile Asn Gln Phe Ser Leu Gln Met 
        195                 200                 205             


Ser Tyr Val Thr Pro Glu Asp Thr Ala Val Tyr Phe Cys Ala Arg Asp 
    210                 215                 220                 


Ala Ala Phe Gly Leu Asp Ala Leu Asp Ile Trp Gly Gln Gly Thr Met 
225                 230                 235                 240 


Val Thr Val Ser Ser 
                245 


<210>  18
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B scFv

<400>  18

Ser Tyr Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Met Asn 
            20                  25                  30          


Thr Val Asn Trp Tyr His Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ser Asn His Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Gly Asp Tyr Tyr Cys Ala Ser Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Ala Pro Lys Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
        115                 120                 125             


Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln Thr 
    130                 135                 140                 


Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn Ser 
145                 150                 155                 160 


Ala Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu Trp 
                165                 170                 175     


Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala Val 
            180                 185                 190         


Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp Thr Ser Lys Asn Gln 
        195                 200                 205             


Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val Tyr 
    210                 215                 220                 


Tyr Cys Ala Arg Asp Ser Gly Gly Trp Leu Asp Pro Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Thr Val Thr Val Ser Ser 
                245         


<210>  19
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR-H1A scFv

<400>  19
agtgtctcta gcaacagtgc tgcttggaac                                        30


<210>  20
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR-H2A scFv

<400>  20
tacaggtcca cgtggtataa t                                                 21


<210>  21
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR-H3A scFv

<400>  21
gcaagagatg cggctttcgg tcttgacgct cttgatatc                              39


<210>  22
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR-H1B scFv

<400>  22
gtctctagca acagtgctgc ttggaac                                           27


<210>  23
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR-H2B scFv

<400>  23
tacaggtcca agtggtataa t                                                 21


<210>  24
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR-H3B scFv

<400>  24
gcaagagatt ccgggggctg gctcgacccc                                        30


<210>  25
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR-L1A scFv

<400>  25
cagagcatta gcagctat                                                     18


<210>  26
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR-L2A scFv

<400>  26
gctgcatcc                                                                9


<210>  27
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR-L3A scFv

<400>  27
caacagagtt acggtacccc tctcact                                           27


<210>  28
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR-L1B scFv

<400>  28
agctccaaca tcggaatgaa tact                                              24


<210>  29
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR-L2B scFv

<400>  29
agtaatcat                                                                9


<210>  30
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR-L3B scFv

<400>  30
gcatcatggg atgacagcct gaatgctcct aagtatgtc                              39


<210>  31
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VHA scFv

<400>  31
caggtacagc tgcagcagtc aggtccagga ctggtgaagc cctcgcaaac cctctcactc       60

acctgcgcca tctccgggga cagtgtctct agcaacagtg ctgcttggaa ctggatcagg      120

cagtccccat cgagaggcct tgagtggctg ggaaggacat actacaggtc cacgtggtat      180

aatgattatg cagtatctgt gaaaagtcga attaccatca acccagacac atccataaac      240

cagttctccc tgcagatgag ttatgtgact cccgaggaca cggctgtgta tttctgtgca      300

agagatgcgg ctttcggtct tgacgctctt gatatctggg gccaagggac aatggtcacc      360

gtctcttca                                                              369


<210>  32
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VHB scFv

<400>  32
caggtacagc tgcagcagtc aggtccagga ctggtgaagc cctcgcagac cctctcactc       60

acctgtgcca tctccgggga cagtgtctct agcaacagtg ctgcttggaa ctggatcagg      120

cagtccccat cgagaggcct tgagtggctg ggaaggacat actacaggtc caagtggtat      180

aatgattatg cagtatctgt gaaaagtcga ataaccatca acccagacac atccaagaac      240

cagttctccc tgcagctgaa ctctgtgact cccgaggaca cggctgtgta ttactgtgca      300

agagattccg ggggctggct cgacccctgg ggccagggaa ccacggtcac cgtctcctca      360


<210>  33
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VLA scFv

<400>  33
gccatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttatta ctgtcaacag agttacggta cccctctcac tttcggcgga      300

gggaccaagg tggaaatcaa a                                                321


<210>  34
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VLB scFv

<400>  34
tcctatgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc       60

tcttgttctg gaagcagctc caacatcgga atgaatactg tgaactggta ccaccagctc      120

ccaggaacgg cccccaaact cctcatctat agtaatcatc agcggccctc aggggtccct      180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccag      240

tctgaggatg agggtgatta ttactgtgca tcatgggatg acagcctgaa tgctcctaag      300

tatgtcttcg gtactgggac caagctgacc gtccta                                336


<210>  35
<211>  735
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  A scFv

<400>  35
gccatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttatta ctgtcaacag agttacggta cccctctcac tttcggcgga      300

gggaccaagg tggaaatcaa aggtggaggc ggttccggag gcggtggcag cggcggtggc      360

ggttcgcagg tacagctgca gcagtcaggt ccaggactgg tgaagccctc gcaaaccctc      420

tcactcacct gcgccatctc cggggacagt gtctctagca acagtgctgc ttggaactgg      480

atcaggcagt ccccatcgag aggccttgag tggctgggaa ggacatacta caggtccacg      540

tggtataatg attatgcagt atctgtgaaa agtcgaatta ccatcaaccc agacacatcc      600

ataaaccagt tctccctgca gatgagttat gtgactcccg aggacacggc tgtgtatttc      660

tgtgcaagag atgcggcttt cggtcttgac gctcttgata tctggggcca agggacaatg      720

gtcaccgtct cttca                                                       735


<210>  36
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B scFv

<400>  36
tcctatgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc       60

tcttgttctg gaagcagctc caacatcgga atgaatactg tgaactggta ccaccagctc      120

ccaggaacgg cccccaaact cctcatctat agtaatcatc agcggccctc aggggtccct      180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccag      240

tctgaggatg agggtgatta ttactgtgca tcatgggatg acagcctgaa tgctcctaag      300

tatgtcttcg gtactgggac caagctgacc gtcctaggtg gaggcggttc cggaggcggt      360

ggtagcggcg gtggcggttc gcaggtacag ctgcagcagt caggtccagg actggtgaag      420

ccctcgcaga ccctctcact cacctgtgcc atctccgggg acagtgtctc tagcaacagt      480

gctgcttgga actggatcag gcagtcccca tcgagaggcc ttgagtggct gggaaggaca      540

tactacaggt ccaagtggta taatgattat gcagtatctg tgaaaagtcg aataaccatc      600

aacccagaca catccaagaa ccagttctcc ctgcagctga actctgtgac tcccgaggac      660

acggctgtgt attactgtgc aagagattcc gggggctggc tcgacccctg gggccaggga      720

accacggtca ccgtctcctc a                                                741



<210>  37
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  37

Gly Gly Gly Gly Ser 
1               5   


<210>  38
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  38

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  39
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  39

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  