                         SEQUENCE LISTING

<110>  Biocytogen PharmaceuticalsBeijingCo., Ltd.
 
<120>  GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC CD20
        GENES

<130>  1

<150>  CN202110668664.5
<151>  2021-06-16

<160>  43    

<170>  PatentIn version 3.5

<210>  1
<211>  291
<212>  PRT
<213>  Mus musculus

<400>  1

Met Ser Gly Pro Phe Pro Ala Glu Pro Thr Lys Gly Pro Leu Ala Met 
1               5                   10                  15      


Gln Pro Ala Pro Lys Val Asn Leu Lys Arg Thr Ser Ser Leu Val Gly 
            20                  25                  30          


Pro Thr Gln Ser Phe Phe Met Arg Glu Ser Lys Ala Leu Gly Ala Val 
        35                  40                  45              


Gln Ile Met Asn Gly Leu Phe His Ile Thr Leu Gly Gly Leu Leu Met 
    50                  55                  60                  


Ile Pro Thr Gly Val Phe Ala Pro Ile Cys Leu Ser Val Trp Tyr Pro 
65                  70                  75                  80  


Leu Trp Gly Gly Ile Met Tyr Ile Ile Ser Gly Ser Leu Leu Ala Ala 
                85                  90                  95      


Ala Ala Glu Lys Thr Ser Arg Lys Ser Leu Val Lys Ala Lys Val Ile 
            100                 105                 110         


Met Ser Ser Leu Ser Leu Phe Ala Ala Ile Ser Gly Ile Ile Leu Ser 
        115                 120                 125             


Ile Met Asp Ile Leu Asn Met Thr Leu Ser His Phe Leu Lys Met Arg 
    130                 135                 140                 


Arg Leu Glu Leu Ile Gln Thr Ser Lys Pro Tyr Val Asp Ile Tyr Asp 
145                 150                 155                 160 


Cys Glu Pro Ser Asn Ser Ser Glu Lys Asn Ser Pro Ser Thr Gln Tyr 
                165                 170                 175     


Cys Asn Ser Ile Gln Ser Val Phe Leu Gly Ile Leu Ser Ala Met Leu 
            180                 185                 190         


Ile Ser Ala Phe Phe Gln Lys Leu Val Thr Ala Gly Ile Val Glu Asn 
        195                 200                 205             


Glu Trp Lys Arg Met Cys Thr Arg Ser Lys Ser Asn Val Val Leu Leu 
    210                 215                 220                 


Ser Ala Gly Glu Lys Asn Glu Gln Thr Ile Lys Met Lys Glu Glu Ile 
225                 230                 235                 240 


Ile Glu Leu Ser Gly Val Ser Ser Gln Pro Lys Asn Glu Glu Glu Ile 
                245                 250                 255     


Glu Ile Ile Pro Val Gln Glu Glu Glu Glu Glu Glu Ala Glu Ile Asn 
            260                 265                 270         


Phe Pro Ala Pro Pro Gln Glu Gln Glu Ser Leu Pro Val Glu Asn Glu 
        275                 280                 285             


Ile Ala Pro 
    290     


<210>  2
<211>  297
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Thr Thr Pro Arg Asn Ser Val Asn Gly Thr Phe Pro Ala Glu Pro 
1               5                   10                  15      


Met Lys Gly Pro Ile Ala Met Gln Ser Gly Pro Lys Pro Leu Phe Arg 
            20                  25                  30          


Arg Met Ser Ser Leu Val Gly Pro Thr Gln Ser Phe Phe Met Arg Glu 
        35                  40                  45              


Ser Lys Thr Leu Gly Ala Val Gln Ile Met Asn Gly Leu Phe His Ile 
    50                  55                  60                  


Ala Leu Gly Gly Leu Leu Met Ile Pro Ala Gly Ile Tyr Ala Pro Ile 
65                  70                  75                  80  


Cys Val Thr Val Trp Tyr Pro Leu Trp Gly Gly Ile Met Tyr Ile Ile 
                85                  90                  95      


Ser Gly Ser Leu Leu Ala Ala Thr Glu Lys Asn Ser Arg Lys Cys Leu 
            100                 105                 110         


Val Lys Gly Lys Met Ile Met Asn Ser Leu Ser Leu Phe Ala Ala Ile 
        115                 120                 125             


Ser Gly Met Ile Leu Ser Ile Met Asp Ile Leu Asn Ile Lys Ile Ser 
    130                 135                 140                 


His Phe Leu Lys Met Glu Ser Leu Asn Phe Ile Arg Ala His Thr Pro 
145                 150                 155                 160 


Tyr Ile Asn Ile Tyr Asn Cys Glu Pro Ala Asn Pro Ser Glu Lys Asn 
                165                 170                 175     


Ser Pro Ser Thr Gln Tyr Cys Tyr Ser Ile Gln Ser Leu Phe Leu Gly 
            180                 185                 190         


Ile Leu Ser Val Met Leu Ile Phe Ala Phe Phe Gln Glu Leu Val Ile 
        195                 200                 205             


Ala Gly Ile Val Glu Asn Glu Trp Lys Arg Thr Cys Ser Arg Pro Lys 
    210                 215                 220                 


Ser Asn Ile Val Leu Leu Ser Ala Glu Glu Lys Lys Glu Gln Thr Ile 
225                 230                 235                 240 


Glu Ile Lys Glu Glu Val Val Gly Leu Thr Glu Thr Ser Ser Gln Pro 
                245                 250                 255     


Lys Asn Glu Glu Asp Ile Glu Ile Ile Pro Ile Gln Glu Glu Glu Glu 
            260                 265                 270         


Glu Glu Thr Glu Thr Asn Phe Pro Glu Pro Pro Gln Asp Gln Glu Ser 
        275                 280                 285             


Ser Pro Ile Glu Asn Asp Ser Ser Pro 
    290                 295         


<210>  3
<211>  4174
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5' homology arm

<400>  3
tagaagtcaa aggggtttgt gggtttgtgg gagctgcagt gggtgataag atggaacggt       60

gggtgagcaa attaaatcat caattcagta tcagtattgt gaagctaaag cctatactgt      120

catattagac caatgtggtc cataccccta gtaatctacc aaacaatctt tgctgtgagc      180

tggagtctat tggagcaatt ttgtatgatt tttttaaaaa taaggcaatg atgcaaaaac      240

ctacatttgt gggaatatat ggaccagctc tagcttccgt tgccactaaa tgtaatttta      300

ttgcaccaac ctgtagtgct ctcacgtgtg tgagaaaggg agggagaaga gggagatcgt      360

tagtataaga tggcatataa aagttattat tttgactaca aaatattatt ttgtagtaat      420

agctattcaa cactttgtag atatacagtt actacaaaga tatgttctac aagagtgatg      480

ttcttctctt catattacta ctgccactag gccatacgga cacccccact gggctttgcc      540

taaataaaag gtttatctca gtaacaacac agacccaaga cttagtgagc agctgataac      600

tcaggtggaa ttatattaat ggtggtccaa tcatttcctt caccctgaac aattaatgac      660

cttgcatttg taagccacca tcactaaaat tagttcccta gaatggagtg aaatgacttc      720

tatctcattc catagttgcc aaaagatctt gggaaaataa cttatgtgaa cttctattga      780

cacatccact aaaaaggtga tacaatgcct cctgggaggg aggtatgaga aaaactggaa      840

ctagaacaac taataaccct gggacacagt acatgttcaa gtaaacaact gtggtcatac      900

aatctagcct ggaggtctac agagtgaggt ataaggtctt tgcaaaagga tgtcccgtgt      960

ctaggggaag gatccatatt tgtgatatga acaaactggt ttctggagat ttttctactt     1020

ctaaaccagt attcatttgc aaactccttg gtgggatata tatatgtata tatatatata     1080

tatatatata tatatatata tatatatata tatgtatatg tatatatata tatatatatt     1140

tttttttttt tttggttagt ggtctcatgg gatggtttgt ggtatgaaac agtcccccgg     1200

gccaagtgac agctgctaat ttaggacagg agggaaatga agtaagaaat gcttccctaa     1260

agcccatgat gttgcagaca ggtcacattc tgtgttgctt taagtcattc ggagtgtgca     1320

tattttgaag ggaaaggaag agaaatgaaa ctgttcccca cttgagtcag agcagtgagt     1380

ctgcccttca gttgacaagt tagggtcttc ttttcagatc attagtaatt acataacttc     1440

aagtgagcta cctaacctgt ctgcccttgt ccactcctct gtaaaacaga ggcaatgatt     1500

cacctcttgt ctcctctgct gggctcagaa gagatgtccc aggaggaatt tctttgtacg     1560

tataaaatag gacgaagtgt aagagatgca cccacccagc cctccatgtc ttagtaagat     1620

tcagcaacct gggtagacac tcttaattcc acagcttaca attagccaga tgtgtggccc     1680

tacagaggga tatccagggt gcagaaaata gcaatgaaat tcaaagacgt ggctgacata     1740

atcagtggat ggatattccc aacacaagac acataaagaa agctaaatag ccttagcctg     1800

tcagagctga aatgaatgtg actcattgtc tcatcacttc agaagcagct catgatcact     1860

ggcagatgat actctctacc ctctaccctg tcctgggtac atatgtccat tcacttctta     1920

tgataattct atgggtagga cactgttctc atttaataga tgcataaagt aaaaactaca     1980

gcttagaagt gtataacaag aatttcaaca aagcagctaa tatttattca gatatgggtg     2040

cttttcataa atctagcatc cctttgatgt taagaagcta taacacgtga gcattgtttt     2100

agatactcgt caaaaagcaa caacattgcc acggaccggg cctagtcgac ccccctcaat     2160

ccgtgtgaat cagggtctcg gacaaatggg catagagtcg gcgggaatgg ggtgacaaac     2220

agactcaaca caagggagtt tggatctgaa tgtaatgtca aattgaacat caaacctttt     2280

atacagaaga aaatagggaa gttaggtgac acatcagcaa ggtacaaatt aggttaccgg     2340

atgcttaatg gctcttacac aaaacaggaa tgtaaacaca aagactggca ggaactgggc     2400

aataaaacaa ctgagacaaa gtcagcccta tctaaggtca gctatagtct tagaagccag     2460

gtgtgaggtc tttacactcc tagggtaagg gctttcacac ccaagtcatg gttctaatta     2520

gggagttcag ctctagctaa ccatctcatg aataatgcaa tactctaaaa ccaccgctca     2580

atctacttcc taaaccattg taaattcctg tatatgggag cgacttggct tttattctaa     2640

gtgatagtgt ggggggactt ctactaataa gtaatgtagt ctgccataca taactataat     2700

aagaattcta aacttacatt gctaagcttg ccctctatag atttagaaat ctatagattt     2760

ctaactctat gcaggagata gtaatgcccg atttctttca ctatctctct tacaatacta     2820

gaagtaattc tgaatgtcac tgaataggca acattcttac tgaattccaa gcccagggtt     2880

ggctcaagga ctaccgaggg cattggtgaa agccagaaag caaagttcga ttttgcttag     2940

gtatttggca aatcattgct tggaggcacc tataataaaa caacactgaa aggaagcaca     3000

cagatccatt cacaaggaca aaattggagc atacgtgcta tggaatgcca cacttccagg     3060

agactaagtt tccgtgaaac tcttcgcctc aggactgcat ccaggctttt ggcctgtcat     3120

gcgtgtcact actgaagtgg atgtagcaca acatcatttg tttctgtcaa gagagaactg     3180

caataaactc gcatataagg taatttacca cagtcatgac tgaaatgagg taactagcac     3240

aggatgtgtt gaggcagggc gcatacacag ggcgcatagg ttgagggttt acagaaggcc     3300

tctgcggata gctggggttt aagctacacc tgggtgaaaa aaaacccaca ccaacatgaa     3360

ccgtcatcat caacctcctg taccacgttg tgagacaagg attcttacta ttttcagtct     3420

agagctgaag aatctgaggc ccaggtaact tggccaacac ctcagagtaa ttagaattac     3480

tgtttaaaac cagacagtct gactcacagg ctgtgattgt acatgtgata tcagagaata     3540

ttcttgaagt gacctgcaca acgtcagagt cagagggaga gagaggtcta gaccatccct     3600

cctgaatttc aggacagtcc tagccataat caagaatgac atgtctgggc tactacactg     3660

tccttctgaa catatgaaca agccaataaa aatatgcttt ggaatattaa atcataagaa     3720

catccaagga gggaccagct agacaaatgc atagagcaga gatgaagcgc ggtggtattt     3780

tcttagcatt cacaaagaga gtccaagccc caccagagaa aaactgcata tggacataaa     3840

tttatggtat ggctatgttc taagagtata gctcactggt aaactaattg actacattgt     3900

gatttcttga acattagcat gtgtccaaac atgattatca tcctagctca gattcctggg     3960

cccatgtgcc cttgcctgag atagcccctc cagatccttt cctataccac ggtagtagac     4020

cttgccttac atctgaagtt actaggaagt ggacatgact cagtggcacc atcaagggac     4080

tactaagaga agtattagat ggtgccagaa ggtaaagatt gccaaagact ctgatctcac     4140

ctcactgtct tattttcagg cgtttgaaaa ctca                                 4174


<210>  4
<211>  4623
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3' homology arm

<400>  4
actcttttct tttctaagca ttattgttta gagagcttcc aagacacata gttaccctca       60

tctcttgtgg ccttccacaa tctattctcc atattttcac agcttaactt tgcatagaga      120

agccacatct agctctcctt cacatttgaa gaatgcagtg attataaaag attgtctttt      180

gccttgctta gggagtctta cactggcaga aacgctgaag aatccaattc tcattcacct      240

tttccttgga tgtgtgtctc agtagtggta atggtttttc cgcatttcct ccatcagcag      300

ttacagcaga gggaaaagac acatgactgt tctgttcatc tctgaactct ctgactcctt      360

cttcatgttt ggtggagtcc cttttgcatg attgtcttaa agaatatgag agaaattgtt      420

taatgagaat tgttttaata atgagagaaa atgagacacc tatatgcctg tggggaaggc      480

acaaaatatg gcatgttctt caagcttctg tgtcccactt gggaagctgt gaaaggccta      540

gtcctaagtc tgtctctgta caaaaagcat agcttacaca taagcaagtt tcatgtctta      600

actttgccca tctccagttt cttggcttct ggtcacatcg tttatgtatt tgtattcttt      660

agtcaagaga aaaaagaatg gtgagacaga aatgtaatgg gttcccagat ctcaaatcct      720

aagcaacagc tgtgctttga gattctttcc aaatggcaga gtagtttatt tggtctttca      780

tgattcacag aaaaaaaaca aaaaaacaaa aaacaaaaaa cctatcacta ttttgtaatt      840

tagttgaatg taagaagcaa gccaagatat tcaataatag ttgtggggac ttgagtcaaa      900

cccagctctt caaattctag aaatgtttga aataaccaaa ttatctatgc ccatatgcct      960

gtataagcta tatcaaagta tatactttgt gagcaatgtg ctgaatcaca aaagagtcag     1020

aattggattt gacaccatat gaataaagac acccagaatc ttacatcatt tggaaaacta     1080

gtcgtgacat taatatgcaa ttagctggaa agttataaga tgcaccacaa acacatctta     1140

tatgcactat aaattaccac acaaagatca tgcttaaaaa caacacagtt aaaatcctaa     1200

atctcaggcc accatacttt cccacccctg ttcctgagca gggatgctag cacctgacct     1260

agaaacactg ttagcctaaa aagatctcac catagcctat cattcagata ccatgacaag     1320

tctgcttcta ggcattatgg gtatatgaac agcttaagtt tcactccttg gaatatttct     1380

attttattag aggctaccgg tgggagttat ttcctgttat tacaaagaaa ctggaagtag     1440

caccttttcc ctgtgtggtc ttcaaaacaa gctctaagta aataaaactt tgtgtcagtg     1500

cctgcaatgg atactccacc ttggatgttt ctttcttctc cataacatca aacaatggga     1560

tgcttctgcc acataatact aacctgtgtt tgaatagtgg cacatccagt catattgagc     1620

tattcctacc tatctgacac atgctcccaa ggagtttact catccagtag gtctttacta     1680

agttctgccc acttacaagc cacagcacga ttctccatat ccattcttct ccatagaagg     1740

taccctaagc taaagaagat accgctatgc ctggagagga tggggaggtg ggaggaggag     1800

tgtcaagctg aaaagtttta aatgcagtat tcaatttgaa aagtttcccc tctctgaaat     1860

tcatttcctt aatgatttta cattagtcat cgtcagattc tcaaataatt agtctttacc     1920

aatttctcat gactaggaga taattttagt gtctatttaa aaagaataaa agttcttgtg     1980

agcctccccc aagaatcttc catcattgta gaatcaaatc tcattaccta atggcagaca     2040

tgtttatcaa agcagaaggt atttctctag cttcaagtta ggttttcctc ttaattttta     2100

ttcttataaa aacaattttg taaccataaa gaacaaaagc tttaaaaaaa atcactttca     2160

cccactggct agacacctac cccaccattg aagagactgt ttggctccat ggtttgggga     2220

ccaataatga gacagaagaa taccaagcaa ggaggcatgt ggtggtacaa aactgcccac     2280

cttgtgacag ctcggaagca aaacgatggc tgcaaatgtt tgggtcccaa tagcccttca     2340

agggcatttt gagcttaggc agtagatatt tagagggtat ttaagatcca aatcacaaca     2400

tatgataagg aatactgtta agaatgttat aaagacaaga cagagatctg caacttcaaa     2460

aatgttagtg cctgaatgaa gaaaataaaa atgtgttcaa agataattag ttggactcca     2520

agtaaggaat aaccatttca acaattgctc atgagactca tgatagccac acaaaattaa     2580

ataaataaac tggaagttta cttcacacag tataaaaaaa aaaaacccta gctcaaaatt     2640

tgatcagaag cataaatgta caagctacca ttaaaaaaat acctaaaaga aaactaaaca     2700

cttaaaatct gtgaccctga attagacaat agtttatttt ttattagata ttttcttttt     2760

ttacatttca aatgttatcc cctttcctca tttttccctc tgagaaactc ccatcccctc     2820

cctcctctcg ctgctcacca acccacccac tcctgcttcc tggtcctggc attcccctac     2880

actggggcat tgagccttca caggaccaag ggcctctcct cccattgatg cccaacaagg     2940

ccatcctctg ctatatatgt ggctagagcc atgaatccct ccatgtgtac tctttggttg     3000

gtggtttagt ccctaggtac tttgacaata gcttcttaaa taagcaaaag aataagcaac     3060

taacaaagat taaatgccat caaaacttta aaattttata atttttaaaa agattttaaa     3120

actattttac ttatgtgcac ctatgtgagc ttgtgtgagt ttagttgtac catatgtgtg     3180

ctggagcctg cagaggccag aggaaggggt gccaaatctc ctggaactaa agataaaagt     3240

ggcttttgag ctgccgtgtg gtgctaggaa ctaaacccag gtcctctgca agaacagtaa     3300

acactctttt tttttaagat ttatttattt atttatttta atatttatgt ttttatttta     3360

ttttacatat gtgagtacac tgtagctgta cagatggttg tgagccctgc atgtggttgt     3420

tgggaattga attttaggac ctctgctggc acttggtgga ctcactcgct ctggtcaacc     3480

ccgctcgttc actccctgct cactccagcc caaagattta ttttttttaa ttaggtattt     3540

tcttcattta catttccagt gctaccccaa aagtccccca aaccctctcc ccctccctcc     3600

actcacactt tttggccctg gctttccctt gtactggggc atataaagtt tgcacgacca     3660

atgggcctct ctttccactg atggctgact aggccatctt ctgatacata tgcagctaga     3720

gacaagagct ccgggggggg gggggggtac tggttagttc ataatgtggt tccacctata     3780

gggttgcata tccctttagc tccttgggta ctttccctag ctcctccatt ggaggccctg     3840

tgatccatcc aatagctgac tgtgagcatc cacttctgtg tttgctaggc cctggcatag     3900

tctcacaaga gacagctata tcagggtcca ttgagccatc tcctaggccc tgagaattta     3960

tgacttaaag gacacaaact ttaaaagtgt aaatacaact cacataaggg gaaaacattt     4020

acagaccctg aatctaacaa agatgctgtc accagaattt agaaagaaag cttaaattaa     4080

tttaacgtgg ggtgatggag agtagtctaa aattttaaat tagaaaatga tttgaacata     4140

ttcttctcca aacaaattgt ataaatggtc aataagcaaa taaaccattc actataatta     4200

ttcactagga aaatgtgaat aaaaacctca gtgtgagaca gcctcacatt catgagattg     4260

gctatcaaca gcaagaagca agaaagtgat gctgaggagc taatggaatt aaaataccca     4320

tagaatactg atacatatat ttatgtagtc tctttggaaa attattttcc aattactaaa     4380

aatactaaat gtaaagtttc catttgaccc aagagttcac taccaggcag atagatgccc     4440

aaggatagaa ctatgaacac acaaacttga gtacaattgt ccatagacaa aaataactaa     4500

aaaattggaa acaactcaaa tgtctaccaa ctaatgggtg aacaggaaaa attatgaaat     4560

tttcatctac caaaagaagg cactcctcat taaggcactc ctcatgttaa ggaacaagta     4620

gcc                                                                   4623


<210>  5
<211>  6094
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence from 60462375 to 60468468 of the NCBI 
       accession number NC_000011.10

<400>  5
atgacaacac ccagaaattc agtaaatggg actttcccgg cagagccaat gaaaggccct       60

attgctatgc aatctggtcc aaaaccactc ttcaggagga tgtcttcact ggtgggcccc      120

acgcaaagct tcttcatgag ggaatctaag actttggggg taagtcagtt gccttccatc      180

ccatgtcgta gggattctct ggctgacaga agctgatgcg gtataggcca catacagaat      240

tcaatccaat ttgaagaatt gggatccaac ctgatgtctt ctttatgtct aacacagtgg      300

gccaaatcag gggtgcatca gagaagttat cacttagatc acctctgggt gatcttatgt      360

caccttttgg ttttggggct tgtatatgca ggggtccccc atcccagtcc attgccagaa      420

tcccaggcat acctgctccc tggaaatgcc ccatgtggtt gaggaaacag attcgaacaa      480

gaaaaagaca aaattcttgg cacctccact gcttccttta ggcattcctc acagctccaa      540

gtcaggagcc agagcttcca accttgtctt tgcctgctag cagtgatgat ttcagctcat      600

ccactgctgc ctctgttctc tccccaggct gtccagatta tgaatgggct cttccacatt      660

gccctggggg gtcttctgat gatcccagca gggatctatg cacccatctg tgtgactgtg      720

tggtaccctc tctggggagg cattatggtg agtaaaagaa tagcagccat ttgggaaatg      780

gtgcagacaa aaatgttaaa aggctccaca gggatatgcc agattatttc tgtgttgagg      840

gaaatatatg agtaggaaat attattgggt taaagtaatt aagaagacag gttgaccaaa      900

ttgagtataa atcccatggt tgagagtcag tggtcctgtt tcatgtgaat tcagagaaag      960

gggccctgca tggatctcac agggactgtc caaagcaaga actctccaaa gtcagttctg     1020

gtggggaggg tggccctaga catttagact agatagcaag atgttttgga aagcaagagg     1080

cagcaggaac atccacttcc atctacccct tcttgcttac aattctgttt ggttactatg     1140

gtacctggtg aaacctgtcc catcacaagt cagtctcatt ttgcttatcg acagagcagc     1200

actcttttgg ctgttttacg tacatgtttt ccaaatctgt aaccctgtct gggtgtggca     1260

cataggacag tgatgtttat ttccccgtga tacttttcat agttgccact ataaaagata     1320

agtccaggat taaaattttc caaacaagta gagatgggtt agaacaagag tttcctccat     1380

tctacagcct gaatgtgaga aaaggaagat gagcaatagt catcatcact tcctgtaaca     1440

gccaatgttt tcatggagtg cctgtgccat tcaggtcaag tatttccttc tgcatcagtt     1500

cactcttcag agggcatcag agtcatttat gtcactgtga accccaaagg gcagttccac     1560

aagttaaaaa caaagaaaaa ctagaaataa aacttttaaa tttatggtat gagtattaat     1620

tgatgaggaa atttgagttc tgtctctttg gtcttactat attcctagtc acagatcccc     1680

agatgattga gtaaaaggca tgaatttagt gtcactgagc ctgaataaag gaggaatatg     1740

acagctgaaa aatgaataca actgataaaa atgggtggat ggttgtgtga aagttgctga     1800

aagtgtaggc ttctttctga ccagttatca atgttaaaaa gtgatctccc tctctcctct     1860

atctcctgtc ttgcccaccc cctctccatc tcccccacct ctctttttta cagtatatta     1920

tttccggatc actcctggca gcaacggaga aaaactccag gaagtgtttg gcaagtaacc     1980

atatgtcctt ctttcccaca tgtcagagaa gtacctattt ttttcggtta aaaactgaga     2040

cccttaaaaa gccaaggtat cacagcctct cagccctaaa aagcaaagac cctccacaat     2100

gttattgtga ttttatttat gaaaaactta gaagcgaggt ctatctgaag tatgttcatg     2160

ggaacagaac taaaagcaga tccatgaaaa ccatacctac agtcttaaga acgttaaatg     2220

ctgtgtgaaa ataatagacc tttctgaaag ccctatcatt tctcccagat caccatttag     2280

gaaaattatc tgatcaatgt catgattgat tcaaattcta gctaagccat tttttggccg     2340

taacattgaa caagtcagtt tacctctatg ttcctgagtt ttcacctaga aaggaagggt     2400

aacagtcctt gctaccatgt gacgtccaat ggagatgaaa ggcagtagag tgtgtgatgg     2460

tgcttcacag gctataaagt actacactgt ggtcttgccc ataaaacccc tagggactca     2520

tctagatcca gaggaaactg gcctgcagag ctgctgatgc tgtatggatg aaaagagttt     2580

agcagcaagt tcgctcccaa aaaattcctc ccccaacact gttactaaac tgtgtcactt     2640

tcataatcaa tgagggaatg ggtggattga gatggttcct gtcttaaagt ggcctgacac     2700

actcagtttg gggggaaaac tttttatgaa catcaaatta ttctctagat acagccagat     2760

ttactgactt gccatgtgta ggtcatagag ccaggaatga aatatgcgca gcataaaata     2820

ataatcaata atcccatatc attatggtac ttgttattta tattttcctg tttcaacctt     2880

ttatcatccc tgcaaggtag aacattcaca ctgatatttt cttacctatg ctacccaaag     2940

acatcagccc taattgtatt ttggaagata gctgactggg gctgattgca acctatgtca     3000

gcaggaatag atgttgttac tgttgttgct tctgcttttt ttatttccat ttatttgata     3060

gtacagatct agagggttct atctgaacct tcccaaccta tacttcataa taccatccca     3120

ctaaagtgtg atacaagaaa cttcttcact ctcttccctc tacctattta tgaaggcaga     3180

taataaactg gataatattt atcttcactt attcaacaaa catttattga gtgcctacta     3240

ggatggtggc agtggcagtg aaggaaatgc aaggatacaa gatatagaat caagggttac     3300

tcttagaatt tttgctttat aaaacagatg gatggtgaat gagataggga agactgagaa     3360

aagaacagga tagagacatg attttatttt atagtgacaa agaggctaaa aacaactgag     3420

agaacttcag tatatttagt tgtagttgct ttgtgagtca gggcagttgc atttggaatt     3480

ccctcccaga ttatgttttc caaagggaaa tcaaacccaa ttaataaatc tgtgtctcca     3540

tttcaggtca aaggaaaaat gataatgaat tcattgagcc tctttgctgc catttctgga     3600

atgattcttt caatcatgga catacttaat attaaaattt cccatttttt aaaaatggag     3660

agtctgaatt ttattagagc tcacacacca tatattaaca tatacaactg tgaaccagct     3720

aatccctctg agaaaaactc cccatctacc caatactgtt acagcataca atctctgttc     3780

ttggtaagtg ttcttggtaa gtgtgagatt ggatttctct ccagggagga aggatgactt     3840

gtttattatg agcatgaact ctggatccag accacctgag tttgctagtt actgtctgtg     3900

tggctttggg aaagaatttt aaccacactg tgcctcaatt tcttcaactg taaaatgggg     3960

atggtaacac tatttatcta atagggttgt tctgaggaat aaataagtta atatatacaa     4020

agcatttaga acagtgtttg gtacacagaa gtgctatata agcattggct ttaacattaa     4080

ttattctcaa catcattaat ggcattaata tttaccatta tattaactaa gatgagcata     4140

gaagaaattc ctaagatgtt atgaatatct tttgcccaag gacttttaaa tgtagagttt     4200

gaaagagata aaaaaaaatg catctcccaa ggatgaagag gtctcctagg catgatgcca     4260

caccaactaa ggctgaatac aatttaattt gagactcatt acttattctt tcctatacag     4320

aattgattct tcaactgatt attcatacct tactttctat cagcaataca cattaaccat     4380

ctgttgtgtg ccaaaagttg tgttaagagt tagggttata aagatgctgt ctcctgtact     4440

agcagttctc acagctattc attacttgtc taaagaattg atctcttaat cgttcaatta     4500

tagtcaacaa taacttactg aacaccaaca atgttctttg tgccattatt acattttcac     4560

cttcattctt ctgttgtttt tcagggcatt ttgtcagtga tgctgatctt tgccttcttc     4620

caggaacttg taatagctgg catcgttgag aatgaatgga aaagaacgtg ctccagaccc     4680

aaatctgtaa gtagtagccc ctctggccaa aacctccctc tagaaaatcc acatccacaa     4740

aggatcattt atggagaatg taatctgatg agttgttgaa actaggagct tgatttaaaa     4800

aaaaaaattg gtcttggcat atttctagaa agcaaataat atgatgtctt gaaatttgaa     4860

ataagtctgt agttagagcc tacagttcta tattctgtgc gtcttttttt tttttttttt     4920

tgagacagag tctcactttg ttgcccaggc tagagtgcaa tggcgcgatc ttggcccagt     4980

gcaacctctg cctccgggtt caggcgattc tcctgcctca ccctcccgag tagctgggat     5040

tacaggcacc cgccatcatg cctggccaat ttttgtattt ttgtagagac gggggttcac     5100

catgttggcc aggccagtct tgaactcccg acctcaggtg atcctcccac ctcagcctcc     5160

gaaagtgctg ggattgcagg cgtgagccac catgccccac ctctgtgcat cttcttatta     5220

accttccctg ctgcttgact tcaggcttcc atcctgattt catgattcca tatacagtgt     5280

gtaaaagcaa gatggttgaa ggttgaaggc taagtcacta gttctttggt ttcatttttc     5340

agtattcccc tcttccctcc ttttcaccta attcctcttc caaaacaaca ggttaaaggg     5400

ctccacaaat gggaaataaa aacagaccaa taatagatat attactaact gcttcagaac     5460

cagactgtta gatttagaat ttagaaatca tcgctaatta cttcattttg catttaaaga     5520

aaaatagtat caaagagaga aaattattct cccagagtta tattcactaa aggcaaatca     5580

gaacgaaaat ctaaactcct ctattactgc aatgttcttt tcccaatacc acgtggtcat     5640

tccaggcact gtggtcaatg tctgctgccc ttgaagattt attcagactt gagttttaat     5700

aaatgacttg ataaggatat aagcacctgc aaaaaaattt tggcatttaa aggcatataa     5760

taaatgacat aagtagcata aaaaccagga ggtatttgat aaatgtttgt ggagattgtt     5820

gacaaaggtg tcagtggtaa aagtaaagaa tggtttgttt aattttctgt tttagaacat     5880

agttctcctg tcagcagaag aaaaaaaaga acagactatt gaaataaaag aagaagtggt     5940

tgggctaact gaaacatctt cccaaccaaa gaatgaagaa gacattgaaa ttattccaat     6000

ccaagaagag gaagaagaag aaacagagac gaactttcca gaacctcccc aagatcagga     6060

atcctcacca atagaaaatg acagctctcc ttaa                                 6094


<210>  6
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  connection between the human CD20 sequence and the upstream mouse
       sequence

<400>  6
cttattttca ggcgtttgaa aactcaatga caacacccag aaattcagta aa               52


<210>  7
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  connection between the human CD20 sequence and the downstream 
       mouse sequence

<400>  7
aaaatgacag ctctccttaa actcttttct tttct                                  35


<210>  8
<211>  78
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  connection between the 5' end of the Neo cassette and the 
       upstream human sequence

<400>  8
cagagttata ttcactaaag gcgtcgacgg tatcgataag cttgatatcg aattccgaag       60

ttcctattct ctagaaag                                                     78


<210>  9
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  connection between the 3' end of the Neo cassette with the 
       downstream human sequence

<400>  9
agtataggaa cttcatcagt caggtacata atggtggatc cactagttct agagcggccg       60

cgttaacaaa tcagaacgaa aatctaaact cctctattac tg                         102


<210>  10
<211>  3002
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mRNA sequence of the modified humanized mouse CD20

<400>  10
actcatcttc aagtacttga gatagaagag gccaactgat ctcagctgtg agtggctaat       60

ttggccctta agccttggag ccttggagcc ttggagaccc aggcgtttga aaactcaatg      120

acaacaccca gaaattcagt aaatgggact ttcccggcag agccaatgaa aggccctatt      180

gctatgcaat ctggtccaaa accactcttc aggaggatgt cttcactggt gggccccacg      240

caaagcttct tcatgaggga atctaagact ttgggggctg tccagattat gaatgggctc      300

ttccacattg ccctgggggg tcttctgatg atcccagcag ggatctatgc acccatctgt      360

gtgactgtgt ggtaccctct ctggggaggc attatgtata ttatttccgg atcactcctg      420

gcagcaacgg agaaaaactc caggaagtgt ttggtcaaag gaaaaatgat aatgaattca      480

ttgagcctct ttgctgccat ttctggaatg attctttcaa tcatggacat acttaatatt      540

aaaatttccc attttttaaa aatggagagt ctgaatttta ttagagctca cacaccatat      600

attaacatat acaactgtga accagctaat ccctctgaga aaaactcccc atctacccaa      660

tactgttaca gcatacaatc tctgttcttg ggcattttgt cagtgatgct gatctttgcc      720

ttcttccagg aacttgtaat agctggcatc gttgagaatg aatggaaaag aacgtgctcc      780

agacccaaat ctaacatagt tctcctgtca gcagaagaaa aaaaagaaca gactattgaa      840

ataaaagaag aagtggttgg gctaactgaa acatcttccc aaccaaagaa tgaagaagac      900

attgaaatta ttccaatcca agaagaggaa gaagaagaaa cagagacgaa ctttccagaa      960

cctccccaag atcaggaatc ctcaccaata gaaaatgaca gctctcctta aactcttttc     1020

ttttctaagc attattgttt agagagcttc caagacacat agttaccctc atctcttgtg     1080

gccttccaca atctattctc catattttca cagcttaact ttgcatagag aagccacatc     1140

tagctctcct tcacatttga agaatgcagt gattataaaa gattgtcttt tgccttgctt     1200

agggagtctt acactggcag aaacgctgaa gaatccaatt ctcattcacc ttttccttgg     1260

atgtgtgtct cagtagtggt aatggttttt ccgcatttcc tccatcagca gttacagcag     1320

agggaaaaga cacatgactg ttctgttcat ctctgaactc tctgactcct tcttcatgtt     1380

tggtggagtc ccttttgcat gattgtctta aagaatatga gagaaattgt ttaatgagaa     1440

ttgttttaat aatgagagaa aatgagacac ctatatgcct gtggggaagg cacaaaatat     1500

ggcatgttct tcaagcttct gtgtcccact tgggaagctg tgaaaggcct agtcctaagt     1560

ctgtctctgt acaaaaagca tagcttacac ataagcaagt ttcatgtctt aactttgccc     1620

atctccagtt tcttggcttc tggtcacatc gtttatgtat ttgtattctt tagtcaagag     1680

aaaaaagaat ggtgagacag aaatgtaatg ggttcccaga tctcaaatcc taagcaacag     1740

ctgtgctttg agattctttc caaatggcag agtagtttat ttggtctttc atgattcaca     1800

gaaaaaaaac aaaaaaacaa aaaacaaaaa acctatcact attttgtaat ttagttgaat     1860

gtaagaagca agccaagata ttcaataata gttgtgggga cttgagtcaa acccagctct     1920

tcaaattcta gaaatgtttg aaataaccaa attatctatg cccatatgcc tgtataagct     1980

atatcaaagt atatactttg tgagcaatgt gctgaatcac aaaagagtca gaattggatt     2040

tgacaccata tgaataaaga cacccagaat cttacatcat ttggaaaact agtcgtgaca     2100

ttaatatgca attagctgga aagttataag atgcaccaca aacacatctt atatgcacta     2160

taaattacca cacaaagatc atgcttaaaa acaacacagt taaaatccta aatctcaggc     2220

caccatactt tcccacccct gttcctgagc agggatgcta gcacctgacc tagaaacact     2280

gttagcctaa aaagatctca ccatagccta tcattcagat accatgacaa gtctgcttct     2340

aggcattatg ggtatatgaa cagcttaagt ttcactcctt ggaatatttc tattttatta     2400

gaggctaccg gtgggagtta tttcctgtta ttacaaagaa actggaagta gcaccttttc     2460

cctgtgtggt cttcaaaaca agctctaagt aaataaaact ttgtgtcagt gcctgcaatg     2520

gatactccac cttggatgtt tctttcttct ccataacatc aaacaatggg atgcttctgc     2580

cacataatac taacctgtgt ttgaatagtg gcacatccag tcatattgag ctattcctac     2640

ctatctgaca catgctccca aggagtttac tcatccagta ggtctttact aagttctgcc     2700

cacttacaag ccacagcacg attctccata tccattcttc tccatagaag gtaccctaag     2760

ctaaagaaga taccgctatg cctggagagg atggggaggt gggaggagga gtgtcaagct     2820

gaaaagtttt aaatgcagta ttcaatttga aaagtttccc ctctctgaaa ttcatttcct     2880

taatgatttt acattagtca tcgtcagatt ctcaaataat tagtctttac caatttctca     2940

tgactaggag ataattttag tgtctattta aaaagaataa aagttcttgt gagcctcaaa     3000

aa                                                                    3002


<210>  11
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  11
tggaggaagc ctcaagtgtc tca                                               23


<210>  12
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  12
cctataccgc atcagcttct gtca                                              24


<210>  13
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  13
actgtgcaga aaaggcaaca ggcta                                             25


<210>  14
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  14
tcctgggacc tactctctcc ttgtg                                             25


<210>  15
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  15
tttacatggc atgcccacaa tggtt                                             25


<210>  16
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  16
attccacctt cactgagttc cctcc                                             25


<210>  17
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  17
ggatcggcca ttgaacaaga t                                                 21


<210>  18
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  18
cagaagaact cgtcaagaag gc                                                22


<210>  19
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  19
gaagtggaca tgactcagtg gcacc                                             25


<210>  20
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  20
aacctgcctg tagaaggcag actga                                             25


<210>  21
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  21
aggtgacata agatcaccca gaggt                                             25


<210>  22
<211>  1409
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5' homology arm

<400>  22
tctatgcagg agatagtaat gcccgatttc tttcactatc tctcttacaa tactagaagt       60

aattctgaat gtcactgaat aggcaacatt cttactgaat tccaagccca gggttggctc      120

aaggactacc gagggcattg gtgaaagcca gaaagcaaag ttcgattttg cttaggtatt      180

tggcaaatca ttgcttggag gcacctataa taaaacaaca ctgaaaggaa gcacacagat      240

ccattcacaa ggacaaaatt ggagcatacg tgctatggaa tgccacactt ccaggagact      300

aagtttccgt gaaactcttc gcctcaggac tgcatccagg cttttggcct gtcatgcgtg      360

tcactactga agtggatgta gcacaacatc atttgtttct gtcaagagag aactgcaata      420

aactcgcata taaggtaatt taccacagtc atgactgaaa tgaggtaact agcacaggat      480

gtgttgaggc agggcgcata cacagggcgc ataggttgag ggtttacaga aggcctctgc      540

ggatagctgg ggtttaagct acacctgggt gaaaaaaaac ccacaccaac atgaaccgtc      600

atcatcaacc tcctgtacca cgttgtgaga caaggattct tactattttc agtctagagc      660

tgaagaatct gaggcccagg taacttggcc aacacctcag agtaattaga attactgttt      720

aaaaccagac agtctgactc acaggctgtg attgtacatg tgatatcaga gaatattctt      780

gaagtgacct gcacaacgtc agagtcagag ggagagagag gtctagacca tccctcctga      840

atttcaggac agtcctagcc ataatcaaga atgacatgtc tgggctacta cactgtcctt      900

ctgaacatat gaacaagcca ataaaaatat gctttggaat attaaatcat aagaacatcc      960

aaggagggac cagctagaca aatgcataga gcagagatga agcgcggtgg tattttctta     1020

gcattcacaa agagagtcca agccccacca gagaaaaact gcatatggac ataaatttat     1080

ggtatggcta tgttctaaga gtatagctca ctggtaaact aattgactac attgtgattt     1140

cttgaacatt agcatgtgtc caaacatgat tatcatccta gctcagattc ctgggcccat     1200

gtgcccttgc ctgagatagc ccctccagat cctttcctat accacggtag tagaccttgc     1260

cttacatctg aagttactag gaagtggaca tgactcagtg gcaccatcaa gggactacta     1320

agagaagtat tagatggtgc cagaaggtaa agattgccaa agactctgat ctcacctcac     1380

tgtcttattt tcaggcgttt gaaaactca                                       1409


<210>  23
<211>  1410
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3' homology arm

<400>  23
actcttttct tttctaagca ttattgttta gagagcttcc aagacacata gttaccctca       60

tctcttgtgg ccttccacaa tctattctcc atattttcac agcttaactt tgcatagaga      120

agccacatct agctctcctt cacatttgaa gaatgcagtg attataaaag attgtctttt      180

gccttgctta gggagtctta cactggcaga aacgctgaag aatccaattc tcattcacct      240

tttccttgga tgtgtgtctc agtagtggta atggtttttc cgcatttcct ccatcagcag      300

ttacagcaga gggaaaagac acatgactgt tctgttcatc tctgaactct ctgactcctt      360

cttcatgttt ggtggagtcc cttttgcatg attgtcttaa agaatatgag agaaattgtt      420

taatgagaat tgttttaata atgagagaaa atgagacacc tatatgcctg tggggaaggc      480

acaaaatatg gcatgttctt caagcttctg tgtcccactt gggaagctgt gaaaggccta      540

gtcctaagtc tgtctctgta caaaaagcat agcttacaca taagcaagtt tcatgtctta      600

actttgccca tctccagttt cttggcttct ggtcacatcg tttatgtatt tgtattcttt      660

agtcaagaga aaaaagaatg gtgagacaga aatgtaatgg gttcccagat ctcaaatcct      720

aagcaacagc tgtgctttga gattctttcc aaatggcaga gtagtttatt tggtctttca      780

tgattcacag aaaaaaaaca aaaaaacaaa aaacaaaaaa cctatcacta ttttgtaatt      840

tagttgaatg taagaagcaa gccaagatat tcaataatag ttgtggggac ttgagtcaaa      900

cccagctctt caaattctag aaatgtttga aataaccaaa ttatctatgc ccatatgcct      960

gtataagcta tatcaaagta tatactttgt gagcaatgtg ctgaatcaca aaagagtcag     1020

aattggattt gacaccatat gaataaagac acccagaatc ttacatcatt tggaaaacta     1080

gtcgtgacat taatatgcaa ttagctggaa agttataaga tgcaccacaa acacatctta     1140

tatgcactat aaattaccac acaaagatca tgcttaaaaa caacacagtt aaaatcctaa     1200

atctcaggcc accatacttt cccacccctg ttcctgagca gggatgctag cacctgacct     1260

agaaacactg ttagcctaaa aagatctcac catagcctat cattcagata ccatgacaag     1320

tctgcttcta ggcattatgg gtatatgaac agcttaagtt tcactccttg gaatatttct     1380

attttattag aggctaccgg tgggagttat                                      1410


<210>  24
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA-3 target site sequence

<400>  24
tggagcaggt tgcatggcga ggg                                               23


<210>  25
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA-10 target site sequence

<400>  25
ggagcgatct cattttccac tgg                                               23


<210>  26
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA3 forward oligonucleotide

<400>  26
taggtggagc aggttgcatg gcgaggg                                           27


<210>  27
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA3 downstream sequence

<400>  27
ccctcgccat gcaacctgct cca                                               23


<210>  28
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA3 reverse oligonucleotide

<400>  28
aaacccctcg ccatgcaacc tgctcca                                           27


<210>  29
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA10 forward oligonucleotide

<400>  29
taggggagcg atctcatttt ccactgg                                           27


<210>  30
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA10 downstream sequence

<400>  30
ccagtggaaa atgagatcgc tcc                                               23


<210>  31
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA10 reverse oligonucleotide

<400>  31
aaacccagtg gaaaatgaga tcgctcc                                           27


<210>  32
<211>  132
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fragment DNA containing T7 promoter and sgRNA scaffold

<400>  32
gaattctaat acgactcact atagggggtc ttcgagaaga cctgttttag agctagaaat       60

agcaagttaa aataaggcta gtccgttatc aacttgaaaa agtggcaccg agtcggtgct      120

tttaaaggat cc                                                          132


<210>  33
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  33
actgtgcaga aaaggcaaca ggcta                                             25


<210>  34
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  34
tcctgggacc tactctctcc ttgtg                                             25


<210>  35
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  35
tttacatggc atgcccacaa tggtt                                             25


<210>  36
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  36
attccacctt cactgagttc cctcc                                             25


<210>  37
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  37
actcctggca gcaacggaga a                                                 21


<210>  38
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  38
tgggtctgga gcacgttctt tt                                                22


<210>  39
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  39
gtcccctcgc catgcaacct                                                   20


<210>  40
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  40
gcatcgccga cagaatgccc                                                   20


<210>  41
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  41
tcaccatctt ccaggagcga ga                                                22


<210>  42
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  42
gaaggccatg ccagtgagct t                                                 21


<210>  43
<211>  298
<212>  PRT
<213>  Rattus norvegicus

<400>  43

Met Thr Thr Pro Arg Asn Ser Val Ser Gly Pro Phe Pro Thr Glu Pro 
1               5                   10                  15      


Thr Lys Gly Pro Leu Ala Met Gln Pro Ala Gln Lys Val Ile Pro Arg 
            20                  25                  30          


Arg Pro Ser Ser Leu Val Gly Pro Thr Gln Ser Phe Phe Met Arg Glu 
        35                  40                  45              


Ser Lys Ala Leu Gly Ala Val Gln Ile Met Asn Gly Leu Phe His Ile 
    50                  55                  60                  


Ser Leu Gly Gly Leu Leu Met Ile Pro Thr Gly Val Phe Ala Pro Ile 
65                  70                  75                  80  


Cys Leu Ser Val Trp Tyr Pro Leu Trp Gly Gly Ile Met Tyr Ile Ile 
                85                  90                  95      


Ser Gly Ser Leu Leu Ala Ala Ala Ala Glu Lys Thr Ser Arg Lys Ser 
            100                 105                 110         


Leu Val Lys Ala Lys Val Ile Met Ser Ser Leu Ser Leu Phe Ala Ala 
        115                 120                 125             


Ile Ser Gly Ile Ile Leu Ser Ile Met Asp Ile Leu Asn Ile Thr Val 
    130                 135                 140                 


Ser His Phe Leu Lys Met Glu Arg Leu Glu Leu Ile Lys Thr Pro Lys 
145                 150                 155                 160 


Leu Tyr Val Asp Ile Tyr Asn Cys Glu Pro Ser Asn Ser Ser Glu Lys 
                165                 170                 175     


Asn Ser Pro Ser Thr Gln Tyr Cys Asn Ser Val Gln Ser Val Phe Leu 
            180                 185                 190         


Gly Ile Leu Ser Val Met Leu Ile Ser Ala Phe Phe Gln Lys Leu Val 
        195                 200                 205             


Thr Ala Gly Val Val Glu Asn Glu Trp Lys Arg Val Cys Ser Arg Pro 
    210                 215                 220                 


Lys Ser Asn Val Val Leu Leu Ser Ala Gly Glu Lys Lys Glu Gln Thr 
225                 230                 235                 240 


Ile Lys Met Lys Glu Glu Ile Ile Glu Leu Ser Gly Val Ser Ser Gln 
                245                 250                 255     


Pro Lys Asn Glu Glu Glu Ile Glu Ile Ile Pro Val Gln Glu Glu Glu 
            260                 265                 270         


Glu Glu Glu Ala Glu Ile Asn Phe Pro Ala Pro Pro Gln Glu Gln Glu 
        275                 280                 285             


Ser Leu Pro Val Glu Asn Glu Ile Ser Pro 
    290                 295             


