                         б

<110>  ѩѧ㶫޹˾
 
<120>  һAFPԭĸ׺Tϸ

<130> 22DX0958FPPC

<160>  63    

<170>  PatentIn version 3.5

<210>  1
<211>  107
<212>  PRT
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  1

Gly Ile Gln Val Glu Gln Ser Pro Pro Asp Leu Ile Leu Gln Glu Gly 
1               5                   10                  15      


Ala Asn Ser Thr Leu Arg Cys Asn Phe Ser Asp Ser Val Asn Asn Leu 
            20                  25                  30          


Gln Trp Phe His Gln Asn Pro Trp Gly Gln Leu Ile Asn Leu Phe Tyr 
        35                  40                  45              


Ile Pro Ser Gly Thr Lys Gln Asn Gly Arg Leu Ser Ala Thr Thr Val 
    50                  55                  60                  


Ala Thr Glu Arg Tyr Ser Leu Leu Tyr Ile Ser Ser Ser Gln Thr Thr 
65                  70                  75                  80  


Asp Ser Gly Val Tyr Phe Cys Ser Gly Gly Ser Asn Tyr Lys Leu Thr 
                85                  90                  95      


Phe Gly Lys Gly Thr Leu Leu Thr Val Asn Pro 
            100                 105         


<210>  2
<211>  113
<212>  PRT
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  2

Asp Thr Gly Val Ser Gln Asp Pro Arg His Lys Ile Thr Lys Arg Gly 
1               5                   10                  15      


Gln Asn Val Thr Phe Arg Cys Asp Pro Ile Ser Glu His Asn Arg Leu 
            20                  25                  30          


Tyr Trp Tyr Arg Gln Thr Leu Gly Gln Gly Pro Glu Phe Leu Thr Tyr 
        35                  40                  45              


Phe Gln Asn Glu Ala Gln Leu Glu Lys Ser Arg Leu Leu Ser Asp Arg 
    50                  55                  60                  


Phe Ser Ala Glu Arg Pro Lys Gly Ser Phe Ser Thr Leu Glu Ile Gln 
65                  70                  75                  80  


Arg Thr Glu Gln Gly Asp Ser Ala Met Tyr Leu Cys Ala Ser Ser Pro 
                85                  90                  95      


Gly Thr Gly Val Gly Tyr Thr Phe Gly Ser Gly Thr Arg Leu Thr Val 
            100                 105                 110         


Val 
    


<210>  3
<211>  202
<212>  PRT
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  3

Met Gly Ile Gln Val Glu Gln Ser Pro Pro Asp Leu Ile Leu Gln Glu 
1               5                   10                  15      


Gly Ala Asn Ser Thr Leu Arg Cys Asn Phe Ser Asp Ser Val Asn Asn 
            20                  25                  30          


Leu Gln Trp Phe His Gln Asn Pro Trp Gly Gln Leu Ile Asn Leu Phe 
        35                  40                  45              


Tyr Ile Pro Ser Gly Thr Lys Gln Asn Gly Arg Leu Ser Ala Thr Thr 
    50                  55                  60                  


Val Ala Thr Glu Arg Tyr Ser Leu Leu Tyr Ile Ser Ser Ser Gln Thr 
65                  70                  75                  80  


Thr Asp Ser Gly Val Tyr Phe Cys Ser Gly Gly Ser Asn Tyr Lys Leu 
                85                  90                  95      


Thr Phe Gly Lys Gly Thr Leu Leu Thr Val Asn Pro Asn Ile Gln Asn 
            100                 105                 110         


Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys 
        115                 120                 125             


Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln 
    130                 135                 140                 


Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Thr Val Leu Asp Met 
145                 150                 155                 160 


Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp Ser Asn Lys 
                165                 170                 175     


Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu 
            180                 185                 190         


Asp Thr Phe Phe Cys Ser Pro Glu Ser Ser 
        195                 200         


<210>  4
<211>  244
<212>  PRT
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  4

Met Asp Thr Gly Val Ser Gln Asp Pro Arg His Lys Ile Thr Lys Arg 
1               5                   10                  15      


Gly Gln Asn Val Thr Phe Arg Cys Asp Pro Ile Ser Glu His Asn Arg 
            20                  25                  30          


Leu Tyr Trp Tyr Arg Gln Thr Leu Gly Gln Gly Pro Glu Phe Leu Thr 
        35                  40                  45              


Tyr Phe Gln Asn Glu Ala Gln Leu Glu Lys Ser Arg Leu Leu Ser Asp 
    50                  55                  60                  


Arg Phe Ser Ala Glu Arg Pro Lys Gly Ser Phe Ser Thr Leu Glu Ile 
65                  70                  75                  80  


Gln Arg Thr Glu Gln Gly Asp Ser Ala Met Tyr Leu Cys Ala Ser Ser 
                85                  90                  95      


Pro Gly Thr Gly Val Gly Tyr Thr Phe Gly Ser Gly Thr Arg Leu Thr 
            100                 105                 110         


Val Val Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val Phe 
        115                 120                 125             


Glu Pro Ser Glu Cys Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val 
    130                 135                 140                 


Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp Trp 
145                 150                 155                 160 


Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro 
                165                 170                 175     


Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Ala Leu Ser Ser 
            180                 185                 190         


Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe 
        195                 200                 205             


Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr 
    210                 215                 220                 


Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp 
225                 230                 235                 240 


Gly Arg Ala Asp 
                


<210>  5
<211>  107
<212>  PRT
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  5

Gly Ile Gln Val Glu Gln Ser Pro Pro Asp Leu Ile Leu Gln Glu Gly 
1               5                   10                  15      


Ala Asn Ser Thr Leu Arg Cys Asn Phe Ser Asp Ser Val Asn Asn Leu 
            20                  25                  30          


Gln Trp Phe His Gln Asn Pro Trp Gly Gln Leu Ile Asn Leu Phe Tyr 
        35                  40                  45              


Ile Pro Ser Gly Thr Lys Gln Asn Gly Arg Leu Ser Ala Thr Thr Val 
    50                  55                  60                  


Ala Thr Glu Arg Tyr Ser Leu Leu Tyr Ile Ser Ser Ser Gln Thr Thr 
65                  70                  75                  80  


Asp Ser Gly Val Tyr Phe Cys Ser Gly Gly Ser Gly Phe Arg Leu Thr 
                85                  90                  95      


Phe Gly Lys Gly Thr Leu Leu Thr Val Asn Pro 
            100                 105         


<210>  6
<211>  107
<212>  PRT
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  6

Gly Ile Gln Val Glu Gln Ser Pro Pro Asp Leu Ile Leu Gln Glu Gly 
1               5                   10                  15      


Ala Asn Ser Thr Leu Arg Cys Asn Phe Ser Asp Ser Val Asn Asn Leu 
            20                  25                  30          


Gln Trp Phe His Gln Asn Pro Trp Gly Gln Leu Ile Asn Leu Phe Tyr 
        35                  40                  45              


Ile Pro Ser Gly Thr Lys Gln Asn Gly Arg Leu Ser Ala Thr Thr Val 
    50                  55                  60                  


Ala Thr Glu Arg Tyr Ser Leu Leu Tyr Ile Ser Ser Ser Gln Thr Thr 
65                  70                  75                  80  


Asp Ser Gly Val Tyr Phe Cys Ser Gly Gly Gln Gly Tyr Lys Leu Thr 
                85                  90                  95      


Phe Gly Lys Gly Thr Leu Leu Thr Val Asn Pro 
            100                 105         


<210>  7
<211>  107
<212>  PRT
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  7

Gly Ile Gln Val Glu Gln Ser Pro Pro Asp Leu Ile Leu Gln Glu Gly 
1               5                   10                  15      


Ala Asn Ser Thr Leu Arg Cys Asn Phe Ser Asp Ser Val Asn Asn Leu 
            20                  25                  30          


Gln Trp Phe His Gln Asn Pro Trp Gly Gln Leu Ile Asn Leu Phe Tyr 
        35                  40                  45              


Ile Pro Ser Gly Thr Lys Gln Asn Gly Arg Leu Ser Ala Thr Thr Val 
    50                  55                  60                  


Ala Thr Glu Arg Tyr Ser Leu Leu Tyr Ile Ser Ser Ser Gln Thr Thr 
65                  70                  75                  80  


Asp Ser Gly Val Tyr Phe Cys Ser Gly Gly Ser Gly Tyr Lys Leu Thr 
                85                  90                  95      


Phe Gly Lys Gly Thr Leu Leu Thr Val Asn Pro 
            100                 105         


<210>  8
<211>  113
<212>  PRT
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  8

Asp Thr Gly Val Ser Gln Asp Pro Arg His Lys Ile Thr Lys Arg Gly 
1               5                   10                  15      


Gln Asn Val Thr Phe Arg Cys Asp Pro Ile Ser Glu His Asn Arg Leu 
            20                  25                  30          


Tyr Trp Tyr Arg Gln Thr Leu Gly Gln Gly Pro Glu Phe Leu Thr Tyr 
        35                  40                  45              


Phe Gln Asn Glu Ala Gln Leu Glu Lys Ser Arg Leu Leu Ser Asp Arg 
    50                  55                  60                  


Phe Ser Ala Glu Arg Pro Lys Gly Ser Phe Ser Thr Leu Glu Ile Gln 
65                  70                  75                  80  


Arg Thr Glu Gln Gly Asp Ser Ala Met Tyr Leu Cys Ala Ser Ser Pro 
                85                  90                  95      


Pro Gln Gly Val Gly Tyr Thr Phe Gly Ser Gly Thr Arg Leu Thr Val 
            100                 105                 110         


Val 
    


<210>  9
<211>  113
<212>  PRT
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  9

Asp Thr Gly Val Ser Gln Asp Pro Arg His Lys Ile Thr Lys Arg Gly 
1               5                   10                  15      


Gln Asn Val Thr Phe Arg Cys Asp Pro Ile Ser Glu His Asn Arg Leu 
            20                  25                  30          


Tyr Trp Tyr Arg Gln Thr Leu Gly Gln Gly Pro Glu Phe Leu Thr Tyr 
        35                  40                  45              


Phe Gln Asn Glu Ala Gln Leu Glu Lys Ser Arg Leu Leu Ser Asp Arg 
    50                  55                  60                  


Phe Ser Ala Glu Arg Pro Lys Gly Ser Phe Ser Thr Leu Glu Ile Gln 
65                  70                  75                  80  


Arg Thr Glu Gln Gly Asp Ser Ala Met Tyr Leu Cys Ala Ser Ser Pro 
                85                  90                  95      


Gly Thr Gly Ile Gln Tyr Glu Phe Gly Ser Gly Thr Arg Leu Thr Val 
            100                 105                 110         


Val 
    


<210>  10
<211>  113
<212>  PRT
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  10

Asp Thr Gly Val Ser Gln Asp Pro Arg His Lys Ile Thr Lys Arg Gly 
1               5                   10                  15      


Gln Asn Val Thr Phe Arg Cys Asp Pro Ile Ser Glu His Asn Arg Leu 
            20                  25                  30          


Tyr Trp Tyr Arg Gln Thr Leu Gly Gln Gly Pro Glu Phe Leu Thr Tyr 
        35                  40                  45              


Phe Gln Asn Glu Ala Gln Leu Glu Lys Ser Arg Leu Leu Ser Asp Arg 
    50                  55                  60                  


Phe Ser Ala Glu Arg Pro Lys Gly Ser Phe Ser Thr Leu Glu Ile Gln 
65                  70                  75                  80  


Arg Thr Glu Gln Gly Asp Ser Ala Met Tyr Leu Cys Ala Ser Ser Pro 
                85                  90                  95      


Gly Thr Gly Ile Gln Tyr Gln Phe Gly Ser Gly Thr Arg Leu Thr Val 
            100                 105                 110         


Val 
    


<210>  11
<211>  113
<212>  PRT
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  11

Asp Thr Gly Val Ser Gln Asp Pro Arg His Lys Ile Thr Lys Arg Gly 
1               5                   10                  15      


Gln Asn Val Thr Phe Arg Cys Asp Pro Ile Ser Glu His Asn Arg Leu 
            20                  25                  30          


Tyr Trp Tyr Arg Gln Thr Leu Gly Gln Gly Pro Glu Phe Leu Thr Tyr 
        35                  40                  45              


Phe Gln Asn Glu Ala Gln Leu Glu Lys Ser Arg Leu Leu Ser Asp Arg 
    50                  55                  60                  


Phe Ser Ala Glu Arg Pro Lys Gly Ser Phe Ser Thr Leu Glu Ile Gln 
65                  70                  75                  80  


Arg Thr Glu Gln Gly Asp Ser Ala Met Tyr Leu Cys Ala Ser Ser Pro 
                85                  90                  95      


Gly Thr Gly Ile Gln Tyr His Phe Gly Ser Gly Thr Arg Leu Thr Val 
            100                 105                 110         


Val 
    


<210>  12
<211>  113
<212>  PRT
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  12

Asp Thr Gly Val Ser Gln Asp Pro Arg His Lys Ile Thr Lys Arg Gly 
1               5                   10                  15      


Gln Asn Val Thr Phe Arg Cys Asp Pro Ile Ser Glu His Asn Arg Leu 
            20                  25                  30          


Tyr Trp Tyr Arg Gln Thr Leu Gly Gln Gly Pro Glu Phe Leu Thr Tyr 
        35                  40                  45              


Phe Gln Asn Glu Ala Gln Leu Glu Lys Ser Arg Leu Leu Ser Asp Arg 
    50                  55                  60                  


Phe Ser Ala Glu Arg Pro Lys Gly Ser Phe Ser Thr Leu Glu Ile Gln 
65                  70                  75                  80  


Arg Thr Glu Gln Gly Asp Ser Ala Met Tyr Leu Cys Ala Ser Ser Pro 
                85                  90                  95      


Gly Thr Gly Ile Gln Tyr Lys Phe Gly Ser Gly Thr Arg Leu Thr Val 
            100                 105                 110         


Val 
    


<210>  13
<211>  113
<212>  PRT
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  13

Asp Thr Gly Val Ser Gln Asp Pro Arg His Lys Ile Thr Lys Arg Gly 
1               5                   10                  15      


Gln Asn Val Thr Phe Arg Cys Asp Pro Ile Ser Glu His Asn Arg Leu 
            20                  25                  30          


Tyr Trp Tyr Arg Gln Thr Leu Gly Gln Gly Pro Glu Phe Leu Thr Tyr 
        35                  40                  45              


Phe Gln Asn Glu Ala Gln Leu Glu Lys Ser Arg Leu Leu Ser Asp Arg 
    50                  55                  60                  


Phe Ser Ala Glu Arg Pro Lys Gly Ser Phe Ser Thr Leu Glu Ile Gln 
65                  70                  75                  80  


Arg Thr Glu Gln Gly Asp Ser Ala Met Tyr Leu Cys Ala Ser Ser His 
                85                  90                  95      


Gln His Gly Val Gly Tyr Thr Phe Gly Ser Gly Thr Arg Leu Thr Val 
            100                 105                 110         


Val 
    


<210>  14
<211>  113
<212>  PRT
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  14

Asp Thr Gly Val Ser Gln Asp Pro Arg His Lys Ile Thr Lys Arg Gly 
1               5                   10                  15      


Gln Asn Val Thr Phe Arg Cys Asp Pro Ile Ser Glu His Asn Arg Leu 
            20                  25                  30          


Tyr Trp Tyr Arg Gln Thr Leu Gly Gln Gly Pro Glu Phe Leu Thr Tyr 
        35                  40                  45              


Phe Gln Asn Glu Ala Gln Leu Glu Lys Ser Arg Leu Leu Ser Asp Arg 
    50                  55                  60                  


Phe Ser Ala Glu Arg Pro Lys Gly Ser Phe Ser Thr Leu Glu Ile Gln 
65                  70                  75                  80  


Arg Thr Glu Gln Gly Asp Ser Ala Met Tyr Leu Cys Ala Ser Ser Pro 
                85                  90                  95      


Pro Gln Gly Ile Gly Tyr Thr Phe Gly Ser Gly Thr Arg Leu Thr Val 
            100                 105                 110         


Val 
    


<210>  15
<211>  113
<212>  PRT
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  15

Asp Thr Gly Val Ser Gln Asp Pro Arg His Lys Ile Thr Lys Arg Gly 
1               5                   10                  15      


Gln Asn Val Thr Phe Arg Cys Asp Pro Ile Ser Glu His Asn Arg Leu 
            20                  25                  30          


Tyr Trp Tyr Arg Gln Thr Leu Gly Gln Gly Pro Glu Phe Leu Thr Tyr 
        35                  40                  45              


Phe Gln Asn Glu Ala Gln Leu Glu Lys Ser Arg Leu Leu Ser Asp Arg 
    50                  55                  60                  


Phe Ser Ala Glu Arg Pro Lys Gly Ser Phe Ser Thr Leu Glu Ile Gln 
65                  70                  75                  80  


Arg Thr Glu Gln Gly Asp Ser Ala Met Tyr Leu Cys Ala Ser Ser Pro 
                85                  90                  95      


Gly Thr Gly Ile Gln Tyr Arg Phe Gly Ser Gly Thr Arg Leu Thr Val 
            100                 105                 110         


Val 
    


<210>  16
<211>  113
<212>  PRT
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  16

Asp Thr Gly Val Ser Gln Asp Pro Arg His Lys Ile Thr Lys Arg Gly 
1               5                   10                  15      


Gln Asn Val Thr Phe Arg Cys Asp Pro Ile Ser Glu His Asn Arg Leu 
            20                  25                  30          


Tyr Trp Tyr Arg Gln Thr Leu Gly Gln Gly Pro Glu Phe Leu Thr Tyr 
        35                  40                  45              


Phe Gln Asn Glu Ala Gln Leu Glu Lys Ser Arg Leu Leu Ser Asp Arg 
    50                  55                  60                  


Phe Ser Ala Glu Arg Pro Lys Gly Ser Phe Ser Thr Leu Glu Ile Gln 
65                  70                  75                  80  


Arg Thr Glu Gln Gly Asp Ser Ala Met Tyr Leu Cys Ala Ser Ser Pro 
                85                  90                  95      


Gly Thr Gly Ile Gln Tyr Thr Phe Gly Ser Gly Thr Arg Leu Thr Val 
            100                 105                 110         


Val 
    


<210>  17
<211>  113
<212>  PRT
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  17

Asp Thr Gly Val Ser Gln Asp Pro Arg His Lys Ile Thr Lys Arg Gly 
1               5                   10                  15      


Gln Asn Val Thr Phe Arg Cys Asp Pro Ile Ser Glu His Asn Arg Leu 
            20                  25                  30          


Tyr Trp Tyr Arg Gln Thr Leu Gly Gln Gly Pro Glu Phe Leu Thr Tyr 
        35                  40                  45              


Phe Gln Asn Glu Ala Gln Leu Glu Lys Ser Arg Leu Leu Ser Asp Arg 
    50                  55                  60                  


Phe Ser Ala Glu Arg Pro Lys Gly Ser Phe Ser Thr Leu Glu Ile Gln 
65                  70                  75                  80  


Arg Thr Glu Gln Gly Asp Ser Ala Met Tyr Leu Cys Ala Ser Ser Pro 
                85                  90                  95      


Gly Thr Gly Ile Arg Gln Leu Phe Gly Ser Gly Thr Arg Leu Thr Val 
            100                 105                 110         


Val 
    


<210>  18
<211>  113
<212>  PRT
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  18

Asp Thr Gly Val Ser Gln Asp Pro Arg His Lys Ile Thr Lys Arg Gly 
1               5                   10                  15      


Gln Asn Val Thr Phe Arg Cys Asp Pro Ile Ser Glu His Asn Arg Leu 
            20                  25                  30          


Tyr Trp Tyr Arg Gln Thr Leu Gly Gln Gly Pro Glu Phe Leu Thr Tyr 
        35                  40                  45              


Phe Gln Asn Glu Ala Gln Leu Glu Lys Ser Arg Leu Leu Ser Asp Arg 
    50                  55                  60                  


Phe Ser Ala Glu Arg Pro Lys Gly Ser Phe Ser Thr Leu Glu Ile Gln 
65                  70                  75                  80  


Arg Thr Glu Gln Gly Asp Ser Ala Met Tyr Leu Cys Ala Ser Ser Pro 
                85                  90                  95      


Gly Thr Gly Ile Arg Phe Gln Phe Gly Ser Gly Thr Arg Leu Thr Val 
            100                 105                 110         


Val 
    


<210>  19
<211>  113
<212>  PRT
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  19

Asp Thr Gly Val Ser Gln Asp Pro Arg His Lys Ile Thr Lys Arg Gly 
1               5                   10                  15      


Gln Asn Val Thr Phe Arg Cys Asp Pro Ile Ser Glu His Asn Arg Leu 
            20                  25                  30          


Tyr Trp Tyr Arg Gln Thr Leu Gly Gln Gly Pro Glu Phe Leu Thr Tyr 
        35                  40                  45              


Phe Gln Asn Glu Ala Gln Leu Glu Lys Ser Arg Leu Leu Ser Asp Arg 
    50                  55                  60                  


Phe Ser Ala Glu Arg Pro Lys Gly Ser Phe Ser Thr Leu Glu Ile Gln 
65                  70                  75                  80  


Arg Thr Glu Gln Gly Asp Ser Ala Met Tyr Leu Cys Ala Ser Ser Pro 
                85                  90                  95      


Gly Thr Gly Ile Ser Tyr Gln Phe Gly Ser Gly Thr Arg Leu Thr Val 
            100                 105                 110         


Val 
    


<210>  20
<211>  113
<212>  PRT
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  20

Asp Thr Gly Val Ser Gln Asp Pro Arg His Lys Ile Thr Lys Arg Gly 
1               5                   10                  15      


Gln Asn Val Thr Phe Arg Cys Asp Pro Ile Ser Glu His Asn Arg Leu 
            20                  25                  30          


Tyr Trp Tyr Arg Gln Thr Leu Gly Gln Gly Pro Glu Phe Leu Thr Tyr 
        35                  40                  45              


Phe Gln Asn Glu Ala Gln Leu Glu Lys Ser Arg Leu Leu Ser Asp Arg 
    50                  55                  60                  


Phe Ser Ala Glu Arg Pro Lys Gly Ser Phe Ser Thr Leu Glu Ile Gln 
65                  70                  75                  80  


Arg Thr Glu Gln Gly Asp Ser Ala Met Tyr Leu Cys Ala Ser Ser Pro 
                85                  90                  95      


Gly Thr Gly Val Ile Tyr Gln Phe Gly Ser Gly Thr Arg Leu Thr Val 
            100                 105                 110         


Val 
    


<210>  21
<211>  113
<212>  PRT
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  21

Asp Thr Gly Val Ser Gln Asp Pro Arg His Lys Ile Thr Lys Arg Gly 
1               5                   10                  15      


Gln Asn Val Thr Phe Arg Cys Asp Pro Ile Ser Glu His Asn Arg Leu 
            20                  25                  30          


Tyr Trp Tyr Arg Gln Thr Leu Gly Gln Gly Pro Glu Phe Leu Thr Tyr 
        35                  40                  45              


Phe Gln Asn Glu Ala Gln Leu Glu Lys Ser Arg Leu Leu Ser Asp Arg 
    50                  55                  60                  


Phe Ser Ala Glu Arg Pro Lys Gly Ser Phe Ser Thr Leu Glu Ile Gln 
65                  70                  75                  80  


Arg Thr Glu Gln Gly Asp Ser Ala Met Tyr Leu Cys Ala Ser Ser Pro 
                85                  90                  95      


Gly Thr Gly Val Gln Tyr Thr Phe Gly Ser Gly Thr Arg Leu Thr Val 
            100                 105                 110         


Val 
    


<210>  22
<211>  113
<212>  PRT
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  22

Asp Thr Gly Val Ser Gln Asp Pro Arg His Lys Ile Thr Lys Arg Gly 
1               5                   10                  15      


Gln Asn Val Thr Phe Arg Cys Asp Pro Ile Ser Glu His Asn Arg Leu 
            20                  25                  30          


Tyr Trp Tyr Arg Gln Thr Leu Gly Gln Gly Pro Glu Phe Leu Thr Tyr 
        35                  40                  45              


Phe Gln Asn Glu Ala Gln Leu Glu Lys Ser Arg Leu Leu Ser Asp Arg 
    50                  55                  60                  


Phe Ser Ala Glu Arg Pro Lys Gly Ser Phe Ser Thr Leu Glu Ile Gln 
65                  70                  75                  80  


Arg Thr Glu Gln Gly Asp Ser Ala Met Tyr Leu Cys Ala Ser Ser Pro 
                85                  90                  95      


Gly Thr Gly Val Arg Tyr Gln Phe Gly Ser Gly Thr Arg Leu Thr Val 
            100                 105                 110         


Val 
    


<210>  23
<211>  113
<212>  PRT
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  23

Asp Thr Gly Val Ser Gln Asp Pro Arg His Lys Ile Thr Lys Arg Gly 
1               5                   10                  15      


Gln Asn Val Thr Phe Arg Cys Asp Pro Ile Ser Glu His Asn Arg Leu 
            20                  25                  30          


Tyr Trp Tyr Arg Gln Thr Leu Gly Gln Gly Pro Glu Phe Leu Thr Tyr 
        35                  40                  45              


Phe Gln Asn Glu Ala Gln Leu Glu Lys Ser Arg Leu Leu Ser Asp Arg 
    50                  55                  60                  


Phe Ser Ala Glu Arg Pro Lys Gly Ser Phe Ser Thr Leu Glu Ile Gln 
65                  70                  75                  80  


Arg Thr Glu Gln Gly Asp Ser Ala Met Tyr Leu Cys Ala Ser Ser Pro 
                85                  90                  95      


Gly Thr Gly Val Val Tyr Gln Phe Gly Ser Gly Thr Arg Leu Thr Val 
            100                 105                 110         


Val 
    


<210>  24
<211>  113
<212>  PRT
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  24

Asp Thr Gly Val Ser Gln Asp Pro Arg His Lys Ile Thr Lys Arg Gly 
1               5                   10                  15      


Gln Asn Val Thr Phe Arg Cys Asp Pro Ile Ser Glu His Asn Arg Leu 
            20                  25                  30          


Tyr Trp Tyr Arg Gln Thr Leu Gly Gln Gly Pro Glu Phe Leu Thr Tyr 
        35                  40                  45              


Phe Gln Asn Glu Ala Gln Leu Glu Lys Ser Arg Leu Leu Ser Asp Arg 
    50                  55                  60                  


Phe Ser Ala Glu Arg Pro Lys Gly Ser Phe Ser Thr Leu Glu Ile Gln 
65                  70                  75                  80  


Arg Thr Glu Gln Gly Asp Ser Ala Met Tyr Leu Cys Ala Ser Ser Pro 
                85                  90                  95      


Gly Thr Gly Ile Leu Tyr Gln Phe Gly Ser Gly Thr Arg Leu Thr Val 
            100                 105                 110         


Val 
    


<210>  25
<211>  113
<212>  PRT
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  25

Asp Thr Gly Val Ser Gln Asp Pro Arg His Lys Ile Thr Lys Arg Gly 
1               5                   10                  15      


Gln Asn Val Thr Phe Arg Cys Asp Pro Ile Ser Glu His Asn Arg Leu 
            20                  25                  30          


Tyr Trp Tyr Arg Gln Thr Leu Gly Gln Gly Pro Glu Phe Leu Thr Tyr 
        35                  40                  45              


Phe Gln Asn Glu Ala Gln Leu Glu Lys Ser Arg Leu Leu Ser Asp Arg 
    50                  55                  60                  


Phe Ser Ala Glu Arg Pro Lys Gly Ser Phe Ser Thr Leu Glu Ile Gln 
65                  70                  75                  80  


Arg Thr Glu Gln Gly Asp Ser Ala Met Tyr Leu Cys Ala Ser Ser Pro 
                85                  90                  95      


Gly Thr Gly Ile Val Tyr Gln Phe Gly Ser Gly Thr Arg Leu Thr Val 
            100                 105                 110         


Val 
    


<210>  26
<211>  113
<212>  PRT
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  26

Asp Thr Gly Val Ser Gln Asp Pro Arg His Lys Ile Thr Lys Arg Gly 
1               5                   10                  15      


Gln Asn Val Thr Phe Arg Cys Asp Pro Ile Ser Glu His Asn Arg Leu 
            20                  25                  30          


Tyr Trp Tyr Arg Gln Thr Leu Gly Gln Gly Pro Glu Phe Leu Thr Tyr 
        35                  40                  45              


Phe Gln Asn Glu Ala Gln Leu Glu Lys Ser Arg Leu Leu Ser Asp Arg 
    50                  55                  60                  


Phe Ser Ala Glu Arg Pro Lys Gly Ser Phe Ser Thr Leu Glu Ile Gln 
65                  70                  75                  80  


Arg Thr Glu Gln Gly Asp Ser Ala Met Tyr Leu Cys Ala Ser Ser Pro 
                85                  90                  95      


Gly Thr Gly Ile Arg Met Gln Phe Gly Ser Gly Thr Arg Leu Thr Val 
            100                 105                 110         


Val 
    


<210>  27
<211>  113
<212>  PRT
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  27

Asp Thr Gly Val Ser Gln Asp Pro Arg His Lys Ile Thr Lys Arg Gly 
1               5                   10                  15      


Gln Asn Val Thr Phe Arg Cys Asp Pro Ile Ser Glu His Asn Arg Leu 
            20                  25                  30          


Tyr Trp Tyr Arg Gln Thr Leu Gly Gln Gly Pro Glu Phe Leu Thr Tyr 
        35                  40                  45              


Phe Gln Asn Glu Ala Gln Leu Glu Lys Ser Arg Leu Leu Ser Asp Arg 
    50                  55                  60                  


Phe Ser Ala Glu Arg Pro Lys Gly Ser Phe Ser Thr Leu Glu Ile Gln 
65                  70                  75                  80  


Arg Thr Glu Gln Gly Asp Ser Ala Met Tyr Leu Cys Ala Ser Ser Pro 
                85                  90                  95      


Gly Thr Gly Ile Arg Tyr Gln Phe Gly Ser Gly Thr Arg Leu Thr Val 
            100                 105                 110         


Val 
    


<210>  28
<211>  201
<212>  PRT
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  28

Gly Ile Gln Val Glu Gln Ser Pro Pro Asp Leu Ile Leu Gln Glu Gly 
1               5                   10                  15      


Ala Asn Ser Thr Leu Arg Cys Asn Phe Ser Asp Ser Val Asn Asn Leu 
            20                  25                  30          


Gln Trp Phe His Gln Asn Pro Trp Gly Gln Leu Ile Asn Leu Phe Tyr 
        35                  40                  45              


Ile Pro Ser Gly Thr Lys Gln Asn Gly Arg Leu Ser Ala Thr Thr Val 
    50                  55                  60                  


Ala Thr Glu Arg Tyr Ser Leu Leu Tyr Ile Ser Ser Ser Gln Thr Thr 
65                  70                  75                  80  


Asp Ser Gly Val Tyr Phe Cys Ser Gly Gly Ser Asn Tyr Lys Leu Thr 
                85                  90                  95      


Phe Gly Lys Gly Thr Leu Leu Thr Val Asn Pro Asn Ile Gln Asn Pro 
            100                 105                 110         


Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser 
        115                 120                 125             


Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser 
    130                 135                 140                 


Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Thr Val Leu Asp Met Arg 
145                 150                 155                 160 


Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser 
                165                 170                 175     


Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp 
            180                 185                 190         


Thr Phe Phe Pro Ser Pro Glu Ser Ser 
        195                 200     


<210>  29
<211>  243
<212>  PRT
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  29

Asp Thr Gly Val Ser Gln Asp Pro Arg His Lys Ile Thr Lys Arg Gly 
1               5                   10                  15      


Gln Asn Val Thr Phe Arg Cys Asp Pro Ile Ser Glu His Asn Arg Leu 
            20                  25                  30          


Tyr Trp Tyr Arg Gln Thr Leu Gly Gln Gly Pro Glu Phe Leu Thr Tyr 
        35                  40                  45              


Phe Gln Asn Glu Ala Gln Leu Glu Lys Ser Arg Leu Leu Ser Asp Arg 
    50                  55                  60                  


Phe Ser Ala Glu Arg Pro Lys Gly Ser Phe Ser Thr Leu Glu Ile Gln 
65                  70                  75                  80  


Arg Thr Glu Gln Gly Asp Ser Ala Met Tyr Leu Cys Ala Ser Ser Pro 
                85                  90                  95      


Gly Thr Gly Val Gly Tyr Thr Phe Gly Ser Gly Thr Arg Leu Thr Val 
            100                 105                 110         


Val Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala Val Phe Glu 
        115                 120                 125             


Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys 
    130                 135                 140                 


Leu Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val 
145                 150                 155                 160 


Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu 
                165                 170                 175     


Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg 
            180                 185                 190         


Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg 
        195                 200                 205             


Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln 
    210                 215                 220                 


Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly 
225                 230                 235                 240 


Arg Ala Asp 
            


<210>  30
<211>  248
<212>  PRT
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  30

Gly Ile Gln Val Glu Gln Ser Pro Pro Asp Leu Ile Leu Gln Glu Gly 
1               5                   10                  15      


Ala Asn Ser Thr Leu Arg Cys Asn Phe Ser Asp Ser Val Asn Asn Leu 
            20                  25                  30          


Gln Trp Phe His Gln Asn Pro Trp Gly Gln Leu Ile Asn Leu Phe Tyr 
        35                  40                  45              


Ile Pro Ser Gly Thr Lys Gln Asn Gly Arg Leu Ser Ala Thr Thr Val 
    50                  55                  60                  


Ala Thr Glu Arg Tyr Ser Leu Leu Tyr Ile Ser Ser Ser Gln Thr Thr 
65                  70                  75                  80  


Asp Ser Gly Val Tyr Phe Cys Ser Gly Gly Ser Asn Tyr Lys Leu Thr 
                85                  90                  95      


Phe Gly Lys Gly Thr Leu Leu Thr Val Asn Pro Asn Ile Gln Asn Pro 
            100                 105                 110         


Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser 
        115                 120                 125             


Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser 
    130                 135                 140                 


Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Thr Val Leu Asp Met Arg 
145                 150                 155                 160 


Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser 
                165                 170                 175     


Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp 
            180                 185                 190         


Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu 
        195                 200                 205             


Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val 
    210                 215                 220                 


Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu 
225                 230                 235                 240 


Met Thr Leu Arg Leu Trp Ser Ser 
                245             


<210>  31
<211>  290
<212>  PRT
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  31

Asp Thr Gly Val Ser Gln Asp Pro Arg His Lys Ile Thr Lys Arg Gly 
1               5                   10                  15      


Gln Asn Val Thr Phe Arg Cys Asp Pro Ile Ser Glu His Asn Arg Leu 
            20                  25                  30          


Tyr Trp Tyr Arg Gln Thr Leu Gly Gln Gly Pro Glu Phe Leu Thr Tyr 
        35                  40                  45              


Phe Gln Asn Glu Ala Gln Leu Glu Lys Ser Arg Leu Leu Ser Asp Arg 
    50                  55                  60                  


Phe Ser Ala Glu Arg Pro Lys Gly Ser Phe Ser Thr Leu Glu Ile Gln 
65                  70                  75                  80  


Arg Thr Glu Gln Gly Asp Ser Ala Met Tyr Leu Cys Ala Ser Ser Pro 
                85                  90                  95      


Gly Thr Gly Val Gly Tyr Thr Phe Gly Ser Gly Thr Arg Leu Thr Val 
            100                 105                 110         


Val Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala Val Phe Glu 
        115                 120                 125             


Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys 
    130                 135                 140                 


Leu Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val 
145                 150                 155                 160 


Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu 
                165                 170                 175     


Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg 
            180                 185                 190         


Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg 
        195                 200                 205             


Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln 
    210                 215                 220                 


Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly 
225                 230                 235                 240 


Arg Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln Gly Val Leu 
                245                 250                 255     


Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr 
            260                 265                 270         


Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys 
        275                 280                 285             


Asp Phe 
    290 



<210>  32
<211>  10
<212>  PRT
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  32

Thr Ser Ser Glu Leu Met Ala Ile Thr Arg 
1               5                   10  


<210>  33
<211>  5
<212>  PRT
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  33

Asp Ser Val Asn Asn 
1               5   


<210>  34
<211>  5
<212>  PRT
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  34

Ile Pro Ser Gly Thr 
1               5   


<210>  35
<211>  9
<212>  PRT
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  35

Ser Gly Gly Ser Gly Phe Arg Leu Thr 
1               5                   


<210>  36
<211>  9
<212>  PRT
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  36

Ser Gly Gly Gln Gly Tyr Lys Leu Thr 
1               5                   


<210>  37
<211>  9
<212>  PRT
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  37

Ser Gly Gly Ser Asn Tyr Lys Leu Thr 
1               5                   


<210>  38
<211>  5
<212>  PRT
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  38

Ser Glu His Asn Arg 
1               5   


<210>  39
<211>  6
<212>  PRT
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  39

Phe Gln Asn Glu Ala Gln 
1               5       


<210>  40
<211>  11
<212>  PRT
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  40

Ala Ser Ser Pro Gly Thr Gly Val Gly Tyr Thr 
1               5                   10      


<210>  41
<211>  11
<212>  PRT
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  41

Ala Ser Ser Pro Pro Gln Gly Val Gly Tyr Thr 
1               5                   10      


<210>  42
<211>  11
<212>  PRT
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  42

Ala Ser Ser Pro Gly Thr Gly Ile Gln Tyr Glu 
1               5                   10      


<210>  43
<211>  11
<212>  PRT
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  43

Ala Ser Ser Pro Gly Thr Gly Ile Gln Tyr Gln 
1               5                   10      


<210>  44
<211>  11
<212>  PRT
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  44

Ala Ser Ser Pro Gly Thr Gly Ile Gln Tyr His 
1               5                   10      


<210>  45
<211>  11
<212>  PRT
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  45

Ala Ser Ser Pro Gly Thr Gly Ile Gln Tyr Lys 
1               5                   10      


<210>  46
<211>  11
<212>  PRT
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  46

Ala Ser Ser His Gln His Gly Val Gly Tyr Thr 
1               5                   10      


<210>  47
<211>  11
<212>  PRT
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  47

Ala Ser Ser Pro Pro Gln Gly Ile Gly Tyr Thr 
1               5                   10      


<210>  48
<211>  11
<212>  PRT
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  48

Ala Ser Ser Pro Gly Thr Gly Ile Gln Tyr Arg 
1               5                   10      


<210>  49
<211>  11
<212>  PRT
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  49

Ala Ser Ser Pro Gly Thr Gly Ile Gln Tyr Thr 
1               5                   10      


<210>  50
<211>  11
<212>  PRT
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  50
Ala Ser Ser Pro Gly Thr Gly Ile Arg Gln Leu 
1               5                   10      


<210>  51
<211>  11
<212>  PRT
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  51

Ala Ser Ser Pro Gly Thr Gly Ile Arg Phe Gln 
1               5                   10      


<210>  52
<211>  11
<212>  PRT
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  52

Ala Ser Ser Pro Gly Thr Gly Ile Ser Tyr Gln 
1               5                   10      


<210>  53
<211>  11
<212>  PRT
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  53

Ala Ser Ser Pro Gly Thr Gly Val Ile Tyr Gln 
1               5                   10      


<210>  54
<211>  11
<212>  PRT
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  54

Ala Ser Ser Pro Gly Thr Gly Val Gln Tyr Thr 
1               5                   10      


<210>  55
<211>  11
<212>  PRT
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  55

Ala Ser Ser Pro Gly Thr Gly Val Arg Tyr Gln 
1               5                   10      


<210>  56
<211>  11
<212>  PRT
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  56

Ala Ser Ser Pro Gly Thr Gly Val Val Tyr Gln 
1               5                   10      


<210>  57
<211>  11
<212>  PRT
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  57

Ala Ser Ser Pro Gly Thr Gly Ile Leu Tyr Gln 
1               5                   10      


<210>  58
<211>  11
<212>  PRT
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  58

Ala Ser Ser Pro Gly Thr Gly Ile Val Tyr Gln 
1               5                   10      


<210>  59
<211>  11
<212>  PRT
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  59

Ala Ser Ser Pro Gly Thr Gly Ile Arg Met Gln 
1               5                   10      


<210>  60
<211>  11
<212>  PRT
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  60

Ala Ser Ser Pro Gly Thr Gly Ile Arg Tyr Gln 
1               5                   10      


<210>  61
<211>  5
<212>  PRT
<213>  ˹

<220>
<223>  Ӷģlinker

<400>  61

Gly Gly Gly Gly Ser 
1               5   


<210>  62
<211>  6
<212>  PRT
<213>  ˹

<220>
<223>  øλNco

<400>  62

Cys Cys Ala Thr Gly Gly 
1               5       


<210>  63
<211>  8
<212>  PRT
<213>  ˹

<220>
<223>  øλNot

<400>  63

Gly Cys Gly Gly Cys Cys Gly Cys 
1               5               