                         SEQUENCE LISTING

<110>  Ikarovec Limited
 
<120>  Retinal Disorders

<130>  AXH/CKW/117964PCT1

<150>  GB2108760.6
<151>  2021-06-18

<150>  GB2204234.5
<151>  2022-03-25

<160>  107   

<170>  PatentIn version 3.5

<210>  1
<211>  508
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cytomegalovirus (CMV) promoter

<400>  1
cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt       60

gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca      120

atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc      180

aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta      240

catgacctta tgggactttc ctacttggca gtacatctac gtattagtca tcgctattac      300

catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg actcacgggg      360

atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc aaaatcaacg      420

ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg gtaggcgtgt      480

acggtgggag gtctatataa gcagagct                                         508


<210>  2
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  truncated form of the CMV promoter

<400>  2
aggtaggcgt gtacggtggg aggtctatat aagcagagct ggtttagtga accgtcagat       60


<210>  3
<211>  583
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  fusion of the CMV early enhancer element and the first intron of 
       the chicken beta-actin gene (CAG)

<400>  3
cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt       60

gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca      120

atgggtggac tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc      180

aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta      240

catgacctta tgggactttc ctacttggca gtacatctac gtattagtca tcgctattac      300

catggtcgag gtgagcccca cgttctgctt cactctcccc atctcccccc cctccccacc      360

cccaattttg tatttattta ttttttaatt attttgtgca gcgatggggg cggggggggg      420

gggggggcgc gcgccaggcg gggcggggcg gggcgagggg cggggcgggg cgaggcggag      480

aggtgcggcg gcagccaatc agagcggcgc gctccgaaag tttcctttta tggcgaggcg      540

gcggcggcgg cggccctata aaaagcgaag cgcgcggcgg gcg                        583


<210>  4
<211>  2039
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  vitelliform macular dystrophy protein-2 (VMD2) promoter

<400>  4
aattctgtca ttttactagg gtgatgaaat tcccaagcaa caccatcctt ttcagataag       60

ggcactgagg ctgagagagg agctgaaacc tacccggcgt caccacacac aggtggcaag      120

gctgggacca gaaaccagga ctgttgactg cagcccggta ttcattcttt ccatagccca      180

cagggctgtc aaagacccca gggcctagtc agaggctcct ccttcctgga gagttcctgg      240

cacagaagtt gaagctcagc acagccccct aacccccaac tctctctgca aggcctcagg      300

ggtcagaaca ctggtggagc agatccttta gcctctggat tttagggcca tggtagaggg      360

ggtgttgccc taaattccag ccctggtctc agcccaacac cctccaagaa gaaattagag      420

gggccatggc caggctgtgc tagccgttgc ttctgagcag attacaagaa gggactaaga      480

caaggactcc tttgtggagg tcctggctta gggagtcaag tgacggcggc tcagcactca      540

cgtgggcagt gccagcctct aagagtgggc aggggcactg gccacagagt cccagggagt      600

cccaccagcc tagtcgccag accttctgtg ggatcatcgg acccacctgg aaccccacct      660

gtgagtacaa ggtgccccag gtggactggg ctggggcttt gaggccttca gggttggatg      720

gccatcttgc gtatttgtgt gggatatgca cacacaggca gcacatgcgc aggtgtgtgg      780

gcacctgtgt gtctgtgcaa atgccctgag gtgggaatga gcttggtgtg catcaggcac      840

agccagccag tgtggctgca gcaaaacaca cagggaaaga atggaggggg catcaatcac      900

tgcttcagta aatttttatt gagcgccttc tacgagaaca caagaggagc ttccattctg      960

aggaggaaac aggcaggaaa caggcagata tcctgtataa tttcaagtag tgataagtgc     1020

tctctagaaa tatcaagcaa ggtgaggaga cacagagcac cggtggcagt ggggctctat     1080

ttccaggttg gatggttggg aacatccttt ctaaagggaa cctggagtgg gaaggaacca     1140

tgcaggtatc tcaggaagag cttcctccag gcaggaagat cagcaggtgg aaaggccctg     1200

gagccaccat tcagtaaaca tcatttgagc atctctacca gctaggttcc attatgggaa     1260

tgggaatatg gtggtggaca gggctgcctg gtcccttcca tacttctcac actagggtgg     1320

ttgagagagc ttgggagcta acgaacaaga tgggctgaga acactgccta gcccagagga     1380

cctgagctta gtgtgtagac attgctgctg ttactgcctt tgtcattgta ttatttattt     1440

atttatttat ttatttttag acagagtttt gctcttctta cccaggctgg agtgcaatgg     1500

cgtgatctca gctcactgca acctccacct cctgggttca agcgattctc ctgcctcagc     1560

ctcctgagta gctgggatta caggcacccg caccacgcct ggataatttt tttgtatttt     1620

tagtagagac agggtttcac catgttggcc aggctggtct cgaactcctg accttaggtg     1680

atccacctgc ctcgacttcc caaagtgctg ggattatagg catgagccac tgcgcccagt     1740

gattatagaa agttaaaggc acatggcaat gcacacgcct atctacgtct tccctgccaa     1800

agcaaagggc agcctctggg ctcactttct tgcgtttcta cttccaaaag gcagtcagaa     1860

ctggcagggc cttggagacc acttcatcca cctcctaggg tccctatggg agagttgagg     1920

tccagagcag ggaagggtcc tgacaggctc tgaccagggc ctctgatccc tacaaacccc     1980

caatcggtgt ccctctctac caggacccaa gcccacctgc tgcagcccac tgcctggcc      2039


<210>  5
<211>  623
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  truncated form of the VMD2 promoter

<400>  5
aattctgtca ttttactagg gtgatgaaat tcccaagcaa caccatcctt ttcagataag       60

ggcactgagg ctgagagagg agctgaaacc tacccggcgt caccacacac aggtggcaag      120

gctgggacca gaaaccagga ctgttgactg cagcccggta ttcattcttt ccatagccca      180

cagggctgtc aaagacccca gggcctagtc agaggctcct ccttcctgga gagttcctgg      240

cacagaagtt gaagctcagc acagccccct aacccccaac tctctctgca aggcctcagg      300

ggtcagaaca ctggtggagc agatccttta gcctctggat tttagggcca tggtagaggg      360

ggtgttgccc taaattccag ccctggtctc agcccaacac cctccaagaa gaaattagag      420

gggccatggc caggctgtgc tagccgttgc ttctgagcag attacaagaa gggactaaga      480

caaggactcc tttgtggagg tcctggctta gggagtcaag tgacggcggc tcagcactca      540

cgtgggcagt gccagcctct aagagtgggc aggggcactg gccacagagt cccagggagt      600

cccaccagcc tagtcgccag acc                                              623


<210>  6
<211>  462
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  truncated form of the VMD2 promoter

<400>  6
tcattctttc catagcccac agggctgtca aagaccccag ggcctagtca gaggctcctc       60

cttcctggag agttcctggc acagaagttg aagctcagca cagcccccta acccccaact      120

ctctctgcaa ggcctcaggg gtcagaacac tggtggagca gatcctttag cctctggatt      180

ttagggccat ggtagagggg gtgttgccct aaattccagc cctggtctca gcccaacacc      240

ctccaagaag aaattagagg ggccatggcc aggctgtgct agccgttgct tctgagcaga      300

ttacaagaag ggactaagac aaggactcct ttgtggaggt cctggcttag ggagtcaagt      360

gacggcggct cagcactcac gtgggcagtg ccagcctcta agagtgggca ggggcactgg      420

ccacagagtc ccagggagtc ccaccagcct agtcgccaga cc                         462


<210>  7
<211>  500
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human phosphoglycerate kinase-1 (PGK) promoter

<400>  7
gggtagggga ggcgcttttc ccaaggcagt ctggagcatg cgctttagca gccccgctgg       60

gcacttggcg ctacacaagt ggcctctggc ctcgcacaca ttccacatcc accggtaggc      120

gccaaccggc tccgttcttt ggtggcccct tcgcgccacc ttctactcct cccctagtca      180

ggaagttccc ccccgccccg cagctcgcgt cgtgcaggac gtgacaaatg gaagtagcac      240

gtctcactag tctcgtgcag atggacagca ccgctgagca atggaagcgg gtaggccttt      300

ggggcagcgg ccaatagcag ctttgctcct tcgctttctg ggctcagagg ctgggaaggg      360

gtgggtccgg gggcgggctc aggggcgggc tcaggggcgg ggcgggcgcc cgaaggtcct      420

ccggaggccc ggcattctgc acgcttcaaa agcgcacgtc tgccgcgctg ttctcctctt      480

cctcatctcc gggcctttcg                                                  500


<210>  8
<211>  1182
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EF1alpha promoter

<400>  8
gctccggtgc ccgtcagtgg gcagagcgca catcgcccac agtccccgag aagttggggg       60

gaggggtcgg caattgaacc ggtgcctaga gaaggtggcg cggggtaaac tgggaaagtg      120

atgtcgtgta ctggctccgc ctttttcccg agggtggggg agaaccgtat ataagtgcag      180

tagtcgccgt gaacgttctt tttcgcaacg ggtttgccgc cagaacacag gtaagtgccg      240

tgtgtggttc ccgcgggcct ggcctcttta cgggttatgg cccttgcgtg ccttgaatta      300

cttccacgcc cctggctgca gtacgtgatt cttgatcccg agcttcgggt tggaagtggg      360

tgggagagtt cgaggccttg cgcttaagga gccccttcgc ctcgtgcttg agttgaggcc      420

tggcttgggc gctggggccg ccgcgtgcga atctggtggc accttcgcgc ctgtctcgct      480

gctttcgata agtctctagc catttaaaat ttttgatgac ctgctgcgac gctttttttc      540

tggcaagata gtcttgtaaa tgcgggccaa gatctgcaca ctggtatttc ggtttttggg      600

gccgcgggcg gcgacggggc ccgtgcgtcc cagcgcacat gttcggcgag gcggggcctg      660

cgagcgcggc caccgagaat cggacggggg tagtctcaag ctggccggcc tgctctggtg      720

cctggcctcg cgccgccgtg tatcgccccg ccctgggcgg caaggctggc ccggtcggca      780

ccagttgcgt gagcggaaag atggccgctt cccggccctg ctgcagggag ctcaaaatgg      840

aggacgcggc gctcgggaga gcgggcgggt gagtcaccca cacaaaggaa aagggccttt      900

ccgtcctcag ccgtcgcttc atgtgactcc acggagtacc gggcgccgtc caggcacctc      960

gattagttct cgagcttttg gagtacgtcg tctttaggtt ggggggaggg gttttatgcg     1020

atggagtttc cccacactga gtgggtggag actgaagtta ggccagcttg gcacttgatg     1080

taattctcct tggaatttgc cctttttgag tttggatctt ggttcattct caagcctcag     1140

acagtggttc aaagtttttt tcttccattt caggtgtcgt ga                        1182


<210>  9
<211>  230
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EF1alpha without the large intron promoter

<400>  9
gctccggtgc ccgtcagtgg gcagagcgca catcgcccac agtccccgag aagttggggg       60

gaggggtcgg caattgaacc ggtgcctaga gaaggtggcg cggggtaaac tgggaaagtg      120

atgtcgtgta ctggctccgc ctttttcccg agggtggggg agaaccgtat ataagtgcag      180

tagtcgccgt gaacgttctt tttcgcaacg ggtttgccgc cagaacacag                 230


<210>  10
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  an anti-VEGF single chain variable fragment (SCVF-1)

<400>  10

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Val Leu Ile 
        35                  40                  45              


Tyr Phe Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Thr Val Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
    130                 135                 140                 


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Asp Phe Thr His 
145                 150                 155                 160 


Tyr Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
                165                 170                 175     


Val Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Ala Asp 
            180                 185                 190         


Phe Lys Arg Arg Phe Thr Phe Ser Leu Asp Thr Ser Lys Ser Thr Ala 
        195                 200                 205             


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Ala Lys Tyr Pro Tyr Tyr Tyr Gly Thr Ser His Trp Tyr Phe Asp 
225                 230                 235                 240 


Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250         


<210>  11
<211>  756
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence encoding SCVF-1

<400>  11
gatatccagc tgacccagag cccttctagc ctgtccgcct ctgtgggcga cagggtgacc       60

atcacatgta gcgcctccca ggatatctcc aactatctga attggtacca gcagaagcca      120

ggcaaggccc ccaaggtgct gatctatttc acctcctctc tgcacagcgg cgtgccatcc      180

agattctctg gcagcggctc cggcaccgac tttaccctga caatcagctc cctgcagcca      240

gaggatttcg ccacatacta ttgccagcag tacagcaccg tgccctggac atttggccag      300

ggcaccaagg tggagatcaa gaggggagga ggaggaggat ctggaggagg aggcagcggc      360

ggcggcggct ccggcggcgg cggctctgag gtgcagctgg tggagtccgg aggaggcctg      420

gtgcagccag gaggatctct gaggctgagc tgtgccgcct ccggctatga cttcacccac      480

tacggaatga actgggtgcg ccaggcacct ggcaagggac tggagtgggt gggctggatc      540

aatacctata caggcgagcc aacctacgcc gccgacttta agcggcggtt caccttcagc      600

ctggatacct ctaagagcac agcctacctg cagatgaact ccctgagggc agaggacacc      660

gccgtgtact attgcgccaa gtatccttac tattacggca caagccactg gtacttcgac      720

gtgtggggac agggcaccct ggtgacagtg tctagc                                756


<210>  12
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-VEGF single chain variable fragment (SCVF-2)

<400>  12

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Val Leu Ile 
        35                  40                  45              


Tyr Phe Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Thr Val Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
    130                 135                 140                 


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asn 
145                 150                 155                 160 


Tyr Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
                165                 170                 175     


Val Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Ala Asp 
            180                 185                 190         


Phe Lys Arg Arg Phe Thr Phe Ser Leu Asp Thr Ser Lys Ser Thr Ala 
        195                 200                 205             


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Ala Lys Tyr Pro His Tyr Tyr Gly Ser Ser His Trp Tyr Phe Asp 
225                 230                 235                 240 


Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250         


<210>  13
<211>  756
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence encoding SCVF-2

<400>  13
gacatccaga tgacccagag ccccagcagc ctgagcgcca gcgtgggcga ccgcgtgacc       60

atcacctgca gcgccagcca ggacatcagc aactacctga actggtacca gcagaagccc      120

ggcaaggccc ccaaggtgct gatctacttc accagcagcc tgcacagcgg cgtgcccagc      180

cgcttcagcg gcagcggcag cggcaccgac ttcaccctga ccatcagcag cctgcagccc      240

gaggacttcg ccacctacta ctgccagcag tacagcaccg tgccctggac cttcggccag      300

ggcaccaagg tggagatcaa gcgcggcggc ggcggcggca gcggcggcgg cggcagcggc      360

ggcggcggca gcggcggcgg cggcagcgag gtgcagctgg tggagagcgg cggcggcctg      420

gtgcagcccg gcggcagcct gcgcctgagc tgcgccgcca gcggctacac cttcaccaac      480

tacggcatga actgggtgcg ccaggccccc ggcaagggcc tggagtgggt gggctggatc      540

aacacctaca ccggcgagcc cacctacgcc gccgacttca agcgccgctt caccttcagc      600

ctggacacca gcaagagcac cgcctacctg cagatgaaca gcctgcgcgc cgaggacacc      660

gccgtgtact actgcgccaa gtacccccac tactacggca gcagccactg gtacttcgac      720

gtgtggggcc agggcaccct ggtgaccgtg agcagc                                756


<210>  14
<211>  255
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-VEGF single chain variable fragment (SCFV-3)

<400>  14

Met Glu Ile Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val 
1               5                   10                  15      


Gly Asp Arg Val Ile Ile Thr Cys Gln Ala Ser Glu Ile Ile His Ser 
            20                  25                  30          


Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Leu Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Ala Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Asn Val Tyr Leu Ala Ser 
                85                  90                  95      


Thr Asn Gly Ala Asn Phe Gly Gln Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
    130                 135                 140                 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr 
145                 150                 155                 160 


Phe Thr Asn Tyr Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly 
                165                 170                 175     


Leu Glu Trp Val Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr 
            180                 185                 190         


Ala Ala Asp Phe Lys Arg Arg Phe Thr Phe Ser Leu Asp Thr Ser Lys 
        195                 200                 205             


Ser Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
    210                 215                 220                 


Val Tyr Tyr Cys Ala Lys Tyr Pro His Tyr Tyr Gly Ser Ser His Trp 
225                 230                 235                 240 


Tyr Phe Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250                 255 


<210>  15
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence encoding SCFV-3

<400>  15
atggagatcg tgatgaccca gagccccagc accctgagcg ccagcgtggg cgaccgcgtg       60

atcatcacct gccaggccag cgagatcatc cacagctggc tggcctggta ccagcagaag      120

cccggcaagg cccccaagct gctgatctac ctggccagca ccctggccag cggcgtgccc      180

agccgcttca gcggcagcgg cagcggcgcc gagttcaccc tgaccatcag cagcctgcag      240

cccgacgact tcgccaccta ctactgccag aacgtgtacc tggccagcac caacggcgcc      300

aacttcggcc agggcaccaa gctgaccgtg ctgggcggcg gcggcggcag cggcggcggc      360

ggcagcggcg gcggcggcag cggcggcggc ggcagcgagg tgcagctggt ggagagcggc      420

ggcggcctgg tgcagcccgg cggcagcctg cgcctgagct gcgccgccag cggctacacc      480

ttcaccaact acggcatgaa ctgggtgcgc caggcccccg gcaagggcct ggagtgggtg      540

ggctggatca acacctacac cggcgagccc acctacgccg ccgacttcaa gcgccgcttc      600

accttcagcc tggacaccag caagagcacc gcctacctgc agatgaacag cctgcgcgcc      660

gaggacaccg ccgtgtacta ctgcgccaag tacccccact actacggcag cagccactgg      720

tacttcgacg tgtggggcca gggcaccctg gtgaccgtga gcagc                      765


<210>  16
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-VEGF single chain variable fragment (SCVF-4)

<400>  16

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Val Leu Ile 
        35                  40                  45              


Tyr Phe Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Thr Val Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
    130                 135                 140                 


Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Ser Leu Thr Asp 
145                 150                 155                 160 


Tyr Tyr Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Val Gly Phe Ile Asp Pro Asp Asp Asp Pro Tyr Tyr Ala Thr Trp 
            180                 185                 190         


Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
        195                 200                 205             


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Ala Gly Gly Asp His Asn Ser Gly Trp Gly Leu Asp Ile Trp Gly 
225                 230                 235                 240 


Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 


<210>  17
<211>  747
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence encoding SCVF-4

<400>  17
gacatccaga tgacccagag ccccagcagc ctgagcgcca gcgtgggcga ccgcgtgacc       60

atcacctgca gcgccagcca ggacatcagc aactacctga actggtacca gcagaagccc      120

ggcaaggccc ccaaggtgct gatctacttc accagcagcc tgcacagcgg cgtgcccagc      180

cgcttcagcg gcagcggcag cggcaccgac ttcaccctga ccatcagcag cctgcagccc      240

gaggacttcg ccacctacta ctgccagcag tacagcaccg tgccctggac cttcggccag      300

ggcaccaagg tggagatcaa gcgcggcggc ggcggcggca gcggcggcgg cggcagcggc      360

ggcggcggca gcggcggcgg cggcagcgag gtgcagctgg tggagagcgg cggcggcctg      420

gtgcagcccg gcggcagcct gcgcctgagc tgcaccgcca gcggcttcag cctgaccgac      480

tactactaca tgacctgggt gcgccaggcc cccggcaagg gcctggagtg ggtgggcttc      540

atcgaccccg acgacgaccc ctactacgcc acctgggcca agggccgctt caccatcagc      600

cgcgacaaca gcaagaacac cctgtacctg cagatgaaca gcctgcgcgc cgaggacacc      660

gccgtgtact actgcgccgg cggcgaccac aacagcggct ggggcctgga catctggggc      720

cagggcaccc tggtgaccgt gagcagc                                          747


<210>  18
<211>  431
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VEGF capture protein-1

<400>  18

Ser Asp Thr Gly Arg Pro Phe Val Glu Met Tyr Ser Glu Ile Pro Glu 
1               5                   10                  15      


Ile Ile His Met Thr Glu Gly Arg Glu Leu Val Ile Pro Cys Arg Val 
            20                  25                  30          


Thr Ser Pro Asn Ile Thr Val Thr Leu Lys Lys Phe Pro Leu Asp Thr 
        35                  40                  45              


Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp Asp Ser Arg Lys Gly Phe 
    50                  55                  60                  


Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile Gly Leu Leu Thr Cys Glu 
65                  70                  75                  80  


Ala Thr Val Asn Gly His Leu Tyr Lys Thr Asn Tyr Leu Thr His Arg 
                85                  90                  95      


Gln Thr Asn Thr Ile Ile Asp Val Val Leu Ser Pro Ser His Gly Ile 
            100                 105                 110         


Glu Leu Ser Val Gly Glu Lys Leu Val Leu Asn Cys Thr Ala Arg Thr 
        115                 120                 125             


Glu Leu Asn Val Gly Ile Asp Phe Asn Trp Glu Tyr Pro Ser Ser Lys 
    130                 135                 140                 


His Gln His Lys Lys Leu Val Asn Arg Asp Leu Lys Thr Gln Ser Gly 
145                 150                 155                 160 


Ser Glu Met Lys Lys Phe Leu Ser Thr Leu Thr Ile Asp Gly Val Thr 
                165                 170                 175     


Arg Ser Asp Gln Gly Leu Tyr Thr Cys Ala Ala Ser Ser Gly Leu Met 
            180                 185                 190         


Thr Lys Lys Asn Ser Thr Phe Val Arg Val His Glu Lys Asp Lys Thr 
        195                 200                 205             


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
    210                 215                 220                 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
225                 230                 235                 240 


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
                245                 250                 255     


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
            260                 265                 270         


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
        275                 280                 285             


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
    290                 295                 300                 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
305                 310                 315                 320 


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
                325                 330                 335     


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
            340                 345                 350         


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
        355                 360                 365             


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
    370                 375                 380                 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
385                 390                 395                 400 


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
                405                 410                 415     


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
            420                 425                 430     


<210>  19
<211>  1293
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence encoding VEGF capture protein-1

<400>  19
agcgacaccg gccgcccctt cgtggagatg tacagcgaga tccccgagat catccacatg       60

accgagggcc gcgagctggt gatcccctgc cgcgtgacca gccccaacat caccgtgacc      120

ctgaagaagt tccccctgga caccctgatc cccgacggca agcgcatcat ctgggacagc      180

cgcaagggct tcatcatcag caacgccacc tacaaggaga tcggcctgct gacctgcgag      240

gccaccgtga acggccacct gtacaagacc aactacctga cccaccgcca gaccaacacc      300

atcatcgacg tggtgctgag ccccagccac ggcatcgagc tgagcgtggg cgagaagctg      360

gtgctgaact gcaccgcccg caccgagctg aacgtgggca tcgacttcaa ctgggagtac      420

cccagcagca agcaccagca caagaagctg gtgaaccgcg acctgaagac ccagagcggc      480

agcgagatga agaagttcct gagcaccctg accatcgacg gcgtgacccg cagcgaccag      540

ggcctgtaca cctgcgccgc cagcagcggc ctgatgacca agaagaacag caccttcgtg      600

cgcgtgcacg agaaggacaa gacccacacc tgccccccct gccccgcccc cgagctgctg      660

ggcggcccca gcgtgttcct gttccccccc aagcccaagg acaccctgat gatcagccgc      720

acccccgagg tgacctgcgt ggtggtggac gtgagccacg aggaccccga ggtgaagttc      780

aactggtacg tggacggcgt ggaggtgcac aacgccaaga ccaagccccg cgaggagcag      840

tacaacagca cctaccgcgt ggtgagcgtg ctgaccgtgc tgcaccagga ctggctgaac      900

ggcaaggagt acaagtgcaa ggtgagcaac aaggccctgc ccgcccccat cgagaagacc      960

atcagcaagg ccaagggcca gccccgcgag ccccaggtgt acaccctgcc ccccagccgc     1020

gacgagctga ccaagaacca ggtgagcctg acctgcctgg tgaagggctt ctaccccagc     1080

gacatcgccg tggagtggga gagcaacggc cagcccgaga acaactacaa gaccaccccc     1140

cccgtgctgg acagcgacgg cagcttcttc ctgtacagca agctgaccgt ggacaagagc     1200

cgctggcagc agggcaacgt gttcagctgc agcgtgatgc acgaggccct gcacaaccac     1260

tacacccaga agagcctgag cctgagcccc ggc                                  1293


<210>  20
<211>  431
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VEGF capture protein-2

<400>  20

Ser Asp Thr Gly Arg Pro Phe Val Glu Met Tyr Ser Glu Ile Pro Glu 
1               5                   10                  15      


Ile Ile His Met Thr Glu Gly Arg Glu Leu Val Ile Pro Cys Arg Val 
            20                  25                  30          


Thr Ser Pro Asn Ile Thr Val Thr Leu Lys Lys Phe Pro Leu Asp Thr 
        35                  40                  45              


Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp Asp Ser Arg Lys Gly Phe 
    50                  55                  60                  


Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile Gly Leu Leu Thr Cys Glu 
65                  70                  75                  80  


Ala Thr Val Asn Gly His Leu Tyr Lys Thr Asn Tyr Leu Thr His Arg 
                85                  90                  95      


Gln Thr Asn Thr Ile Ile Asp Val Val Leu Ser Pro Ser His Gly Ile 
            100                 105                 110         


Glu Leu Ser Val Gly Glu Lys Leu Val Leu Asn Cys Thr Ala Arg Thr 
        115                 120                 125             


Glu Leu Asn Val Gly Ile Asp Phe Asn Trp Glu Tyr Pro Ser Ser Lys 
    130                 135                 140                 


His Gln His Lys Lys Leu Val Asn Arg Asp Leu Lys Thr Gln Ser Gly 
145                 150                 155                 160 


Ser Glu Met Lys Lys Phe Leu Ser Thr Leu Thr Ile Asp Gly Val Thr 
                165                 170                 175     


Arg Ser Asp Gln Gly Leu Tyr Thr Cys Ala Ala Ser Ser Gly Leu Met 
            180                 185                 190         


Thr Lys Lys Asn Ser Thr Phe Val Arg Val His Glu Lys Asp Lys Thr 
        195                 200                 205             


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser 
    210                 215                 220                 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
225                 230                 235                 240 


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
                245                 250                 255     


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
            260                 265                 270         


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
        275                 280                 285             


Ser Val Leu Thr Val Leu Ala Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
    290                 295                 300                 


Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr 
305                 310                 315                 320 


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
                325                 330                 335     


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
            340                 345                 350         


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
        355                 360                 365             


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
    370                 375                 380                 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
385                 390                 395                 400 


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
                405                 410                 415     


Leu His Asn Ala Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
            420                 425                 430     


<210>  21
<211>  1293
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence encoding VEGF capture protein-2

<400>  21
agcgacaccg gccgcccctt cgtggagatg tacagcgaga tccccgagat catccacatg       60

accgagggcc gcgagctggt gatcccctgc cgcgtgacca gccccaacat caccgtgacc      120

ctgaagaagt tccccctgga caccctgatc cccgacggca agcgcatcat ctgggacagc      180

cgcaagggct tcatcatcag caacgccacc tacaaggaga tcggcctgct gacctgcgag      240

gccaccgtga acggccacct gtacaagacc aactacctga cccaccgcca gaccaacacc      300

atcatcgacg tggtgctgag ccccagccac ggcatcgagc tgagcgtggg cgagaagctg      360

gtgctgaact gcaccgcccg caccgagctg aacgtgggca tcgacttcaa ctgggagtac      420

cccagcagca agcaccagca caagaagctg gtgaaccgcg acctgaagac ccagagcggc      480

agcgagatga agaagttcct gagcaccctg accatcgacg gcgtgacccg cagcgaccag      540

ggcctgtaca cctgcgccgc cagcagcggc ctgatgacca agaagaacag caccttcgtg      600

cgcgtgcacg agaaggacaa gacccacacc tgccccccct gccccgcccc cgaggccgcc      660

ggcggcccca gcgtgttcct gttccccccc aagcccaagg acaccctgat gatcagccgc      720

acccccgagg tgacctgcgt ggtggtggac gtgagccacg aggaccccga ggtgaagttc      780

aactggtacg tggacggcgt ggaggtgcac aacgccaaga ccaagccccg cgaggagcag      840

tacaacagca cctaccgcgt ggtgagcgtg ctgaccgtgc tggcccagga ctggctgaac      900

ggcaaggagt acaagtgcaa ggtgagcaac aaggccctgg gcgcccccat cgagaagacc      960

atcagcaagg ccaagggcca gccccgcgag ccccaggtgt acaccctgcc ccccagccgc     1020

gacgagctga ccaagaacca ggtgagcctg acctgcctgg tgaagggctt ctaccccagc     1080

gacatcgccg tggagtggga gagcaacggc cagcccgaga acaactacaa gaccaccccc     1140

cccgtgctgg acagcgacgg cagcttcttc ctgtacagca agctgaccgt ggacaagagc     1200

cgctggcagc agggcaacgt gttcagctgc agcgtgatgc acgaggccct gcacaacgcc     1260

tacacccaga agagcctgag cctgagcccc ggc                                  1293


<210>  22
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-C3b single chain variable fragment

<400>  22

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ala Thr Leu Pro 
                85                  90                  95      


Thr Phe Glu Gln Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
    130                 135                 140                 


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Thr Ser 
145                 150                 155                 160 


Ser Ser Val Ser Pro Gly Lys Gly Leu Glu Trp Val Gly Leu Ile Tyr 
                165                 170                 175     


Pro Tyr Asn Gly Phe Asn Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe 
            180                 185                 190         


Thr Ile Ser Ala Asp Thr Ser Leu Gln Met Asn Ser Leu Arg Ala Glu 
        195                 200                 205             


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asn Ala Leu Tyr Gly Ser Gly 
    210                 215                 220                 


Gly Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
225                 230                 235                 240 


Ser Ser 
        


<210>  23
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence encoding anti-C3b single chain variable 
       fragment

<400>  23
gacatccaga tgacccagag ccccagcagc ctgagcgcca gcgtgggcga ccgcgtgacc       60

atcacctgcc gcgccagcca ggacgtaagc accgccgtgg cctggtacca gcagaagccc      120

ggcaaggccc ccaagctgct gatctacagc gccagcttcc tgtacagcgg cgtgcccagc      180

cgcttcagcg gcagcggcag cggcaccgac ttcaccctga ccatcagcag cctgcagccc      240

gaggacttcg ccacctacta ctgccagcag agctacgcca ccctgcccac cttcgagcag      300

ggcaccaagg tggagatcaa gcgcggcggc ggcggcggca gcggcggcgg cggcagcggc      360

ggcggcggca gcggcggcgg cggcagcgag gtgcagctgg tggagagcgg cggcggcctg      420

gtgcagcccg gcggcagcct gcgcctgagc tgcgccgcca gcggcttcag cttcaccagc      480

agcagcgtga gccccggcaa gggcctggag tgggtgggcc tgatctaccc ctacaacggc      540

ttcaactact acgccgacag cgtgaagggc cgcttcacca tcagcgccga caccagcctg      600

cagatgaaca gcctgcgcgc cgaggacacc gccgtgtact actgcgcccg caacgccctg      660

tacggcagcg gcggctacta cgccatggac tactggggcc agggcaccct ggtgaccgtg      720

agcagc                                                                 726


<210>  24
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-Bb single chain variable fragment

<400>  24

Asp Val Gln Ile Thr Gln Ser Pro Ser Tyr Leu Ala Ala Ser Pro Gly 
1               5                   10                  15      


Glu Thr Ile Thr Ile Asn Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Asp Lys Pro Gly Lys Thr Asn Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Gly Ser Thr Leu Gln Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Met Tyr Tyr Cys Gln Gln His Asp Glu Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Lys Pro Gly 
    130                 135                 140                 


Ala Ser Val Arg Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn 
145                 150                 155                 160 


Tyr Trp Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp 
                165                 170                 175     


Ile Gly Tyr Ile Asn Pro Asn Thr Gly Tyr Asn Asp Tyr Asn Gln Lys 
            180                 185                 190         


Phe Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val 
        195                 200                 205             


Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Ala Arg Gly Gly Gln Leu Gly Leu Arg Arg Ala Met Asp Tyr Trp 
225                 230                 235                 240 


Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
                245                 250 


<210>  25
<211>  750
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence encoding anti-Bb single chain variable 
       fragment

<400>  25
gacgtgcaga tcacccagag ccccagctac ctggccgcca gccccggcga gaccatcacc       60

atcaactgcc gcgccagcaa gagcatcagc aagtacctgg cctggtacca ggacaagccc      120

ggcaagacca acaagctgct gatctacagc ggcagcaccc tgcagagcgg catccccagc      180

cgcttcagcg gcagcggcag cggcaccgac ttcaccctga ccatcagcag cctggagccc      240

gaggacttcg ccatgtacta ctgccagcag cacgacgagt acccctggac cttcggcggc      300

ggcaccaagc tggagatcaa gcgcggcggc ggcggcggca gcggcggcgg cggcagcggc      360

ggcggcggca gcggcggcgg cggcagccag gtgcagctgc agcagagcgg cgccgagctg      420

gccaagcccg gcgccagcgt gcgcatgagc tgcaaggcca gcggctacac cttcaccaac      480

tactggatcc actgggtgaa gcagcgcccc ggccagggcc tggagtggat cggctacatc      540

aaccccaaca ccggctacaa cgactacaac cagaagttca aggacaaggc caccctgacc      600

gccgacaaga gcagcagcac cgtgtacatg cagctgagca gcctgaccag cgaggacagc      660

gccgtgtact actgcgcccg cggcggccag ctgggcctgc gccgcgccat ggactactgg      720

ggccagggca ccagcgtgac cgtgagcagc                                       750


<210>  26
<211>  320
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  soluble (non-membrane bound) form of CD55 (sCD55)

<400>  26

Asp Cys Gly Leu Pro Pro Asp Val Pro Asn Ala Gln Pro Ala Leu Glu 
1               5                   10                  15      


Gly Arg Thr Ser Phe Pro Glu Asp Thr Val Ile Thr Tyr Lys Cys Glu 
            20                  25                  30          


Glu Ser Phe Val Lys Ile Pro Gly Glu Lys Asp Ser Val Ile Cys Leu 
        35                  40                  45              


Lys Gly Ser Gln Trp Ser Asp Ile Glu Glu Phe Cys Asn Arg Ser Cys 
    50                  55                  60                  


Glu Val Pro Thr Arg Leu Asn Ser Ala Ser Leu Lys Gln Pro Tyr Ile 
65                  70                  75                  80  


Thr Gln Asn Tyr Phe Pro Val Gly Thr Val Val Glu Tyr Glu Cys Arg 
                85                  90                  95      


Pro Gly Tyr Arg Arg Glu Pro Ser Leu Ser Pro Lys Leu Thr Cys Leu 
            100                 105                 110         


Gln Asn Leu Lys Trp Ser Thr Ala Val Glu Phe Cys Lys Lys Lys Ser 
        115                 120                 125             


Cys Pro Asn Pro Gly Glu Ile Arg Asn Gly Gln Ile Asp Val Pro Gly 
    130                 135                 140                 


Gly Ile Leu Phe Gly Ala Thr Ile Ser Phe Ser Cys Asn Thr Gly Tyr 
145                 150                 155                 160 


Lys Leu Phe Gly Ser Thr Ser Ser Phe Cys Leu Ile Ser Gly Ser Ser 
                165                 170                 175     


Val Gln Trp Ser Asp Pro Leu Pro Glu Cys Arg Glu Ile Tyr Cys Pro 
            180                 185                 190         


Ala Pro Pro Gln Ile Asp Asn Gly Ile Ile Gln Gly Glu Arg Asp His 
        195                 200                 205             


Tyr Gly Tyr Arg Gln Ser Val Thr Tyr Ala Cys Asn Lys Gly Phe Thr 
    210                 215                 220                 


Met Ile Gly Glu His Ser Ile Tyr Cys Thr Val Asn Asn Asp Glu Gly 
225                 230                 235                 240 


Glu Trp Ser Gly Pro Pro Pro Glu Cys Arg Gly Lys Ser Leu Thr Ser 
                245                 250                 255     


Lys Val Pro Pro Thr Val Gln Lys Pro Thr Thr Val Asn Val Pro Thr 
            260                 265                 270         


Thr Glu Val Ser Pro Thr Ser Gln Lys Thr Thr Thr Lys Thr Thr Thr 
        275                 280                 285             


Pro Asn Ala Gln Ala Thr Arg Ser Thr Pro Val Ser Arg Thr Thr Lys 
    290                 295                 300                 


His Phe His Glu Thr Thr Pro Asn Lys Gly Ser Gly Thr Thr Ser Gly 
305                 310                 315                 320 


<210>  27
<211>  960
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence encoding sCD55

<400>  27
gactgcggcc tgccccccga cgtgcccaac gcccagcccg ccctggaggg ccgcaccagc       60

ttccccgagg acaccgtgat cacctacaag tgcgaggaga gcttcgtgaa gatccccggc      120

gagaaggaca gcgtgatctg cctgaagggc agccagtgga gcgacatcga ggagttctgc      180

aaccgcagct gcgaggtgcc cacccgcctg aacagcgcca gcctgaagca gccctacatc      240

acccagaact acttccccgt gggcaccgtg gtggagtacg agtgccgccc cggctaccgc      300

cgcgagccca gcctgagccc caagctgacc tgcctgcaga acctgaagtg gagcaccgcc      360

gtggagttct gcaagaagaa gagctgcccc aaccccggcg agatccgcaa cggccagatc      420

gacgtgcccg gcggcatcct gttcggcgcc accatcagct tcagctgcaa caccggctac      480

aagctgttcg gcagcaccag cagcttctgc ctgatcagcg gcagcagcgt gcagtggagc      540

gaccccctgc ccgagtgccg cgagatctac tgccccgccc ccccccagat cgacaacggc      600

atcatccagg gcgagcgcga ccactacggc taccgccaga gcgtgaccta cgcctgcaac      660

aagggcttca ccatgatcgg cgagcacagc atctactgca ccgtgaacaa cgacgagggc      720

gagtggagcg gccccccccc cgagtgccga ggcaagagcc tgaccagcaa ggtgcccccc      780

accgtgcaga agcccaccac cgtgaacgtg cccaccaccg aggtgagccc caccagccag      840

aagaccacca ccaagaccac cacccccaac gcccaggcca cccgcagcac ccccgtgagc      900

cgcaccacca agcacttcca cgagaccacc cccaacaagg gcagcggcac caccagcggc      960


<210>  28
<211>  312
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human complement factor H related protein-1 (CFHR1)

<400>  28

Glu Ala Thr Phe Cys Asp Phe Pro Lys Ile Asn His Gly Ile Leu Tyr 
1               5                   10                  15      


Asp Glu Glu Lys Tyr Lys Pro Phe Ser Gln Val Pro Thr Gly Glu Val 
            20                  25                  30          


Phe Tyr Tyr Ser Cys Glu Tyr Asn Phe Val Ser Pro Ser Lys Ser Phe 
        35                  40                  45              


Trp Thr Arg Ile Thr Cys Thr Glu Glu Gly Trp Ser Pro Thr Pro Lys 
    50                  55                  60                  


Cys Leu Arg Leu Cys Phe Phe Pro Phe Val Glu Asn Gly His Ser Glu 
65                  70                  75                  80  


Ser Ser Gly Gln Thr His Leu Glu Gly Asp Thr Val Gln Ile Ile Cys 
                85                  90                  95      


Asn Thr Gly Tyr Arg Leu Gln Asn Asn Glu Asn Asn Ile Ser Cys Val 
            100                 105                 110         


Glu Arg Gly Trp Ser Thr Pro Pro Lys Cys Arg Ser Thr Asp Thr Ser 
        115                 120                 125             


Cys Val Asn Pro Pro Thr Val Gln Asn Ala His Ile Leu Ser Arg Gln 
    130                 135                 140                 


Met Ser Lys Tyr Pro Ser Gly Glu Arg Val Arg Tyr Glu Cys Arg Ser 
145                 150                 155                 160 


Pro Tyr Glu Met Phe Gly Asp Glu Glu Val Met Cys Leu Asn Gly Asn 
                165                 170                 175     


Trp Thr Glu Pro Pro Gln Cys Lys Asp Ser Thr Gly Lys Cys Gly Pro 
            180                 185                 190         


Pro Pro Pro Ile Asp Asn Gly Asp Ile Thr Ser Phe Pro Leu Ser Val 
        195                 200                 205             


Tyr Ala Pro Ala Ser Ser Val Glu Tyr Gln Cys Gln Asn Leu Tyr Gln 
    210                 215                 220                 


Leu Glu Gly Asn Lys Arg Ile Thr Cys Arg Asn Gly Gln Trp Ser Glu 
225                 230                 235                 240 


Pro Pro Lys Cys Leu His Pro Cys Val Ile Ser Arg Glu Ile Met Glu 
                245                 250                 255     


Asn Tyr Asn Ile Ala Leu Arg Trp Thr Ala Lys Gln Lys Leu Tyr Leu 
            260                 265                 270         


Arg Thr Gly Glu Ser Ala Glu Phe Val Cys Lys Arg Gly Tyr Arg Leu 
        275                 280                 285             


Ser Ser Arg Ser His Thr Leu Arg Thr Thr Cys Trp Asp Gly Lys Leu 
    290                 295                 300                 


Glu Tyr Pro Thr Cys Ala Lys Arg 
305                 310         


<210>  29
<211>  936
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence encoding CFHR1

<400>  29
gaagcaacat tttgtgattt tccaaaaata aaccatggaa ttctatatga tgaagaaaaa       60

tataagccat tttcccaggt tcctacaggg gaagttttct attactcctg tgaatataat      120

tttgtgtctc cttcaaaatc attttggact cgcataacat gcacagaaga aggatggtca      180

ccaacaccaa agtgtctcag actgtgtttc tttccttttg tggaaaatgg tcattctgaa      240

tcttcaggac aaacacatct ggaaggtgat actgtgcaaa ttatttgcaa cacaggatac      300

agacttcaaa acaatgagaa caacatttca tgtgtagaac ggggctggtc cacccctccc      360

aaatgcaggt ccactgacac ttcctgtgtg aatccgccca cagtacaaaa tgctcatata      420

ctgtcgagac agatgagtaa atatccatct ggtgagagag tacgttatga atgtaggagc      480

ccttatgaaa tgtttgggga tgaagaagtg atgtgtttaa atggaaactg gacagaacca      540

cctcaatgca aagattctac gggaaaatgt gggccccctc cacctattga caatggggac      600

attacttcat tcccgttgtc agtatatgct ccagcttcat cagttgagta ccaatgccag      660

aacttgtatc aacttgaggg taacaagcga ataacatgta gaaatggaca atggtcagaa      720

ccaccaaaat gcttacatcc gtgtgtaata tcccgagaaa ttatggaaaa ttataacata      780

gcattaaggt ggacagccaa acagaagctt tatttgagaa caggtgaatc agctgaattt      840

gtgtgtaaac ggggatatcg tctttcatca cgttctcaca cattgcgaac aacatgttgg      900

gatgggaaac tggagtatcc aacttgtgca aaaaga                                936


<210>  30
<211>  936
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  codon optimised nucleic acid sequence encoding CFHR1

<400>  30
gaggccacct tctgcgactt ccccaagatc aaccacggca tcctgtacga cgaggagaag       60

tacaagccct tcagccaggt gcccaccggc gaggtgttct actacagctg cgagtacaac      120

ttcgtgagcc ccagcaagag cttctggacc cgcatcacct gcaccgagga gggctggagc      180

cccaccccca agtgcctgcg cctgtgcttc ttccccttcg tggagaacgg ccacagcgag      240

agcagcggcc agacccacct ggagggcgac accgtgcaga tcatctgcaa caccggctac      300

cgcctgcaga acaacgagaa caacatcagc tgcgtggagc gcggctggag cacccccccc      360

aagtgccgca gcaccgacac cagctgcgtg aaccccccca ccgtgcagaa cgcccacatc      420

ctgagccgcc agatgagcaa gtaccccagc ggcgagcgcg tgcgctacga gtgccgcagc      480

ccctacgaga tgttcggcga cgaggaggtg atgtgcctga acggcaactg gaccgagccc      540

ccccagtgca aggacagcac cggcaagtgc ggcccccccc cccccatcga caacggcgac      600

atcaccagct tccccctgag cgtgtacgcc cccgccagca gcgtggagta ccagtgccag      660

aacctgtacc agctggaggg caacaagcgc atcacctgcc gcaacggcca gtggagcgag      720

ccccccaagt gcctgcaccc ctgcgtgatc agccgcgaga tcatggagaa ctacaacatc      780

gccctgcgct ggaccgccaa gcagaagctg tacctgcgca ccggcgagag cgccgagttc      840

gtgtgcaagc gcggctaccg cctgagcagc cgcagccaca ccctgcgcac cacctgctgg      900

gacggcaagc tggagtaccc cacctgcgcc aagcgc                                936


<210>  31
<211>  310
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  soluble (non-membrane-bound) form of CD46 (sCD46)

<400>  31

Cys Glu Glu Pro Pro Thr Phe Glu Ala Met Glu Leu Ile Gly Lys Pro 
1               5                   10                  15      


Lys Pro Tyr Tyr Glu Ile Gly Glu Arg Val Asp Tyr Lys Cys Lys Lys 
            20                  25                  30          


Gly Tyr Phe Tyr Ile Pro Pro Leu Ala Thr His Thr Ile Cys Asp Arg 
        35                  40                  45              


Asn His Thr Trp Leu Pro Val Ser Asp Asp Ala Cys Tyr Arg Glu Thr 
    50                  55                  60                  


Cys Pro Tyr Ile Arg Asp Pro Leu Asn Gly Gln Ala Val Pro Ala Asn 
65                  70                  75                  80  


Gly Thr Tyr Glu Phe Gly Tyr Gln Met His Phe Ile Cys Asn Glu Gly 
                85                  90                  95      


Tyr Tyr Leu Ile Gly Glu Glu Ile Leu Tyr Cys Glu Leu Lys Gly Ser 
            100                 105                 110         


Val Ala Ile Trp Ser Gly Lys Pro Pro Ile Cys Glu Lys Val Leu Cys 
        115                 120                 125             


Thr Pro Pro Pro Lys Ile Lys Asn Gly Lys His Thr Phe Ser Glu Val 
    130                 135                 140                 


Glu Val Phe Glu Tyr Leu Asp Ala Val Thr Tyr Ser Cys Asp Pro Ala 
145                 150                 155                 160 


Pro Gly Pro Asp Pro Phe Ser Leu Ile Gly Glu Ser Thr Ile Tyr Cys 
                165                 170                 175     


Gly Asp Asn Ser Val Trp Ser Arg Ala Ala Pro Glu Cys Lys Val Val 
            180                 185                 190         


Lys Cys Arg Phe Pro Val Val Glu Asn Gly Lys Gln Ile Ser Gly Phe 
        195                 200                 205             


Gly Lys Lys Phe Tyr Tyr Lys Ala Thr Val Met Phe Glu Cys Asp Lys 
    210                 215                 220                 


Gly Phe Tyr Leu Asp Gly Ser Asp Thr Ile Val Cys Asp Ser Asn Ser 
225                 230                 235                 240 


Thr Trp Asp Pro Pro Val Pro Lys Cys Leu Lys Val Leu Pro Pro Ser 
                245                 250                 255     


Ser Thr Lys Pro Pro Ala Leu Ser His Ser Val Ser Thr Ser Ser Thr 
            260                 265                 270         


Thr Lys Ser Pro Ala Ser Ser Ala Ser Gly Pro Arg Pro Thr Tyr Lys 
        275                 280                 285             


Pro Pro Val Ser Asn Tyr Pro Gly Tyr Pro Lys Pro Glu Glu Gly Ile 
    290                 295                 300                 


Leu Asp Ser Leu Asp Val 
305                 310 


<210>  32
<211>  930
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence encoding sCD46

<400>  32
tgcgaggagc cccccacctt cgaggccatg gagctgatcg gcaagcccaa gccctactac       60

gagatcggcg agcgcgtgga ctacaagtgc aagaagggct acttctacat cccccccctg      120

gccacccaca ccatctgcga ccgcaaccac acctggctgc ccgtgagcga cgacgcctgc      180

taccgcgaga cctgccccta catccgcgac cccctgaacg gccaggccgt gcccgccaac      240

ggcacctacg agttcggcta ccagatgcac ttcatctgca acgagggcta ctacctgatc      300

ggcgaggaga tcctgtactg cgagctgaag ggcagcgtgg ccatctggag cggcaagccc      360

cccatctgcg agaaggtgct gtgcaccccc ccccccaaga tcaagaacgg caagcacacc      420

ttcagcgagg tggaggtgtt cgagtacctg gacgccgtga cctacagctg cgaccccgcc      480

cccggccccg accccttcag cctgatcggc gagagcacca tctactgcgg cgacaacagc      540

gtgtggagcc gcgccgcccc cgagtgcaag gtggtgaagt gccgcttccc cgtggtggag      600

aacggcaagc agatcagcgg cttcggcaag aagttctact acaaggccac cgtgatgttc      660

gagtgcgaca agggcttcta cctggacggc agcgacacca tcgtgtgcga cagcaacagc      720

acctgggacc cccccgtgcc caagtgcctg aaggtgctgc cccccagcag caccaagccc      780

cccgccctga gccacagcgt gagcaccagc agcaccacca agagccccgc cagcagcgcc      840

agcggccccc gccccaccta caagcccccc gtgagcaact accccggcta ccccaagccc      900

gaggagggca tcctggacag cctggacgtg                                       930


<210>  33
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CTGF single chain variable fragment (anti-CTGF SCVF-1)

<400>  33

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Glu Gly Gln Leu Val Gln Ser Gly Gly Gly Leu Val His Pro Gly 
    130                 135                 140                 


Gly Ser Leu Arg Leu Ser Cys Ala Gly Ser Gly Phe Thr Phe Ser Ser 
145                 150                 155                 160 


Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
                165                 170                 175     


Val Ser Gly Ile Gly Thr Gly Gly Gly Thr Tyr Ser Thr Asp Ser Val 
            180                 185                 190         


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
        195                 200                 205             


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Met Ala Val Tyr Tyr Cys 
    210                 215                 220                 


Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Phe Phe Asp Cys Trp Gly 
225                 230                 235                 240 


Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 


<210>  34
<211>  747
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence encoding anti-CTGF SCVF-1

<400>  34
gacatccaga tgacccagag ccccagcagc ctgagcgcca gcgtgggcga ccgcgtgacc       60

atcacctgcc gcgccagcca gggcatcagc agctggctgg cctggtacca gcagaagccc      120

gagaaggccc ccaagagcct gatctacgcc gccagcagcc tccagagcgg cgtgcccagc      180

cgcttcagcg gcagcggcag cggcaccgac ttcaccctga ccatcagcag cctccagccc      240

gaggacttcg ccacctacta ctgccagcag tacaacagct acccccccac cttcggccag      300

ggcaccaagc tggagatcaa gcgcggcggc ggcggcggca gcggcggcgg cggcagcggc      360

ggcggcggca gcggcggcgg cggcagcgag ggccagctgg tgcagagcgg cggcggcctg      420

gtgcaccccg gcggcagcct gcgcctgagc tgcgccggca gcggcttcac cttcagcagc      480

tacggcatgc actgggtgcg ccaggccccc ggcaagggcc tggagtgggt gagcggcatc      540

ggcaccggcg gcggcaccta cagcaccgac agcgtgaagg gccgcttcac catcagccgc      600

gacaacgcca agaacagcct gtacctccag atgaacagcc tgcgcgccga ggacatggcc      660

gtgtactact gcgcccgcgg cgactactac ggcagcggca gcttcttcga ctgctggggc      720

cagggcaccc tggtgaccgt gagcagc                                          747


<210>  35
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CTGF single chain variable fragment (anti-CTGF SCVF-2)

<400>  35

Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly 
1               5                   10                  15      


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp 
            20                  25                  30          


Tyr Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gly Ile Thr Glu Thr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Ser 
        115                 120                 125             


Ala Leu Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro 
    130                 135                 140                 


Gly Gln Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly 
145                 150                 155                 160 


Ser Asn Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys 
                165                 170                 175     


Leu Leu Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg 
            180                 185                 190         


Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly 
        195                 200                 205             


Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp 
    210                 215                 220                 


Ser Leu Gly Ala Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
225                 230                 235                 240 


Ala 
    


<210>  36
<211>  723
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence encoding the anti-CTGF SCVF-2

<400>  36
gccgaggtgc agctggtgga gagcggcggc ggcgtggtgc ggcctggcgg cagcctgcgc       60

ctgagctgcg ccgccagcgg cttcaccttc gacgactacg gcatgagctg ggtgcgccag      120

gctccaggca agggcctgga gtgggtgagc tacatcagca gcagcggcag caccatctac      180

tacgccgaca gcgtgaaggg ccgcttcacc atcagccgcg acaacgccaa gaacagcctg      240

tacctgcaga tgaacagcct gcgcgccgag gacaccgccg tgtactactg cgcacgaggc      300

atcaccgaga cctggggcca gggcaccctg gtgaccgtga gcagcggcgg cggcggcagc      360

ggcggcggcg gcagcggcgg cagcgccctg cagagcgtgc tgacccagcc acccagcgcc      420

agcggcaccc ctggccagcg cgtgaccatc agctgcagcg gcagcagcag caacatcggc      480

agcaacaccg tgaactggta ccagcagctg cccggcaccg cgcctaagct gctgatctac      540

agcaacaacc agcgccccag cggcgtgccc gaccgcttca gcggcagcaa gagcggcacc      600

agcgccagcc tggccatcag cggcctgcag agcgaggacg aggccgacta ctactgcgcc      660

gcctgggacg acagcctggg cgccgtgttc ggcggcggca ccaagctgac cgtgctgggc      720

gcc                                                                    723


<210>  37
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P2A peptide spacer sequence

<400>  37

Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  38
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence encoding P2A peptide spacer sequence

<400>  38
gccaccaact tcagcctgct gaagcaggcc ggcgacgtgg aggagaaccc cggcccc          57


<210>  39
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E2A peptide spacer sequence

<400>  39

Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp Val Glu Ser 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  40
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence encoding E2A peptide spacer sequence

<400>  40
cagtgcacca actacgccct gctgaagctg gccggcgacg tggagagcaa ccccggcccc       60


<210>  41
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T2A peptide spacer sequence

<400>  41

Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210>  42
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence encoding T2A peptide spacer sequence

<400>  42
gagggccgcg gcagcctgct gacctgcggc gacgtggagg agaaccccgg cccc             54


<210>  43
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F2A peptide spacer sequence

<400>  43

Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val 
1               5                   10                  15      


Glu Ser Asn Pro Gly Pro 
            20          


<210>  44
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence encoding F2A peptide spacer sequence

<400>  44
gtgaagcaga ccctgaactt cgacctgctg aagctggccg gcgacgtgga gagcaacccc       60

ggcccc                                                                  66


<210>  45
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  viral-2A removal sequence consensus sequence


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  X = basic amino acid

<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  X = basic amino acid

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  X = hydrophilic amino acid

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  X = basic amino acid

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  X = basic amino acid

<400>  45

Xaa Xaa Xaa Xaa Xaa Ser 
1               5       


<210>  46
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  viral-2A removal sequence wherein the hydrophilic amino acid is 
       serine (S)

<400>  46

Arg Arg Ser Lys Arg Ser Gly Ser Gly 
1               5                   


<210>  47
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence encoding viral-2A removal sequence wherein 
       the hydrophilic amino acid is serine (S)

<400>  47
cgccgcagca agcgcagcgg cagcggc                                           27


<210>  48
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  viral-2A removal sequence wherein the hydrophilic amino acid is 
       threonine (T)

<400>  48

Arg Arg Thr Lys Arg Ser Gly Ser Gly 
1               5                   


<210>  49
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence encoding viral-2A removal sequence wherein 
       the hydrophilic amino acid is threonine (T)

<400>  49
cgccgcacca agcgcagcgg cagcggc                                           27


<210>  50
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  viral-2A removal sequence

<400>  50

Arg Val Arg Arg Gly Ser Gly 
1               5           


<210>  51
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence encoding viral-2A removal sequence of SEQ 
       ID NO: 50

<400>  51
cgcgtgcgcc gcggcagcgg c                                                 21


<210>  52
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  gelatinase MMP-2 recognition sequence

<400>  52

Gly Pro Gln Gly Ile Ala Gly Gln 
1               5               


<210>  53
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  gelatinase MMP-2 recognition sequence

<400>  53

Gly Pro Leu Gly Ile Ala Gly Ala 
1               5               


<210>  54
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  gelatinase MMP-2 recognition sequence

<400>  54

Gly Pro Gln Gly Leu Leu Gly Gln 
1               5               


<210>  55
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  gelatinase MMP-2 recognition sequence and the tripeptide GSG 
       linker sequence

<400>  55

Gly Pro Gln Gly Ile Ala Gly Gln Gly Ser Gly 
1               5                   10      


<210>  56
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence encoding gelatinase MMP-2 recognition 
       sequence and the tripeptide GSG linker sequence

<400>  56
ggccccctgg gcatcgccgg ccagggcagc ggc                                    33


<210>  57
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  renin recognition sequence

<400>  57

His Pro Phe His Leu Val Tyr Ser 
1               5               


<210>  58
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  renin recognition sequence

<400>  58

His Pro Phe His Leu Leu Val Tyr Ser 
1               5                   


<210>  59
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  renin recognition sequence and the tripeptide GSG linker sequence

<400>  59

His Pro Phe His Leu Leu Val Tyr Ser Gly Ser Gly 
1               5                   10          


<210>  60
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence encoding renin recognition sequence and the
       tripeptide GSG linker sequence

<400>  60
cgccccttcc acctgctggt catccacggc agcggc                                 36


<210>  61
<211>  592
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Woodchuck Hepatitis Virus Post-transcriptional Regulatory Element
       (WPRE)

<400>  61
aatcaacctc tggattacaa aatttgtgaa agattgactg gtattcttaa ctatgttgct       60

ccttttacgc tatgtggata cgctgcttta atgcctttgt atcatgctat tgcttcccgt      120

atggctttca ttttctcctc cttgtataaa tcctggttgc tgtctcttta tgaggagttg      180

tggcccgttg tcaggcaacg tggcgtggtg tgcactgtgt ttgctgacgc aacccccact      240

ggttggggca ttgccaccac ctgtcagctc ctttccggga ctttcgcttt ccccctccct      300

attgccacgg cggaactcat cgccgcctgc cttgcccgct gctggacagg ggctcggctg      360

ttgggcactg acaattccgt ggtgttgtcg gggaagctga cgtcctttcc atggctgctc      420

gcctgtgttg ccacctggat tctgcgcggg acgtccttct gctacgtccc ttcggccctc      480

aatccagcgg accttccttc ccgcggcctg ctgccggctc tgcggcctct tccgcgtctt      540

cgccttcgcc ctcagacgag tcggatctcc ctttgggccg cctccccgcc tg              592


<210>  62
<211>  247
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  truncated WPRE

<400>  62
aatcaacctc tggattacaa aatttgtgaa agattgactg gtattcttaa ctatgttgct       60

ccttttacgc tatgtggata cgctgcttta atgcctttgt atcatgctat tgcttcccgt      120

atggctttca ttttctcctc cttgtataaa tcctggttag ttcttgccac ggcggaactc      180

atcgccgcct gccttgcccg ctgctggaca ggggctcggc tgttgggcac tgacaattcc      240

gtggtgt                                                                247


<210>  63
<211>  224
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  the simian virus-40 poly-A nucleotide sequence

<400>  63
agcagacatg ataagataca ttgatgagtt tggacaaacc acaactagaa tgcagtgaaa       60

aaaatgcttt atttgtgaaa tttgtgatgc tattgcttta tttgtaacca ttataagctg      120

caataaacaa gttaacaaca acaattgcat tcattttatg tttcaggttc agggggaggt      180

gtgggaggtt ttttaaagca agtaaaacct ctacaaatgt ggta                       224


<210>  64
<211>  169
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence polyA component

<400>  64
ttcgagcaac ttgtttattg cagcttataa tggttacaaa taaagcaata gcatcacaaa       60

tttcacaaat aaagcatttt tttcactgca ttctagttgt ggtttgtcca aactcatcaa      120

tgtatcttat catgtctgga tcgtctagca tcgaagatcc cccgatctg                  169


<210>  65
<211>  128
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  left ITR sequence taken from a commercially available recombinant
       AAV genome plasmid

<400>  65
cgcgctcgct cgctcactga ggccgcccgg gcaaagcccg ggcgtcgggc gacctttggt       60

cgcccggcct cagtgagcga gcgagcgcgc agagagggag tggccaactc catcactagg      120

ggttcctt                                                               128


<210>  66
<211>  128
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  right ITR sequence taken from a commercially available 
       recombinant AAV genome plasmid

<400>  66
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg       60

ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc      120

gagcgcgc                                                               128


<210>  67
<211>  121
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  minute virus of mice (MVM) small intron

<400>  67
aggtacgatg gcgcctccag ctaaaagagc taaaagaggt aagggtttaa gggatggttg       60

gttggtgggg tattaatgtt taattacctg ttttacaggc ctgaaatcac ttggttttag      120

g                                                                      121


<210>  68
<211>  133
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence from the 5'-donor sites of the first intron of the human
       beta-globin gene and the branch and 3'-acceptor sites from the 
       intron of an immunoglobulin gene heavy chain variable region

<400>  68
gtaagtatca aggttacaag acaggtttaa ggagaccaat agaaactggg cttgtcgaga       60

cagagaagac tcttgcgttt ctgataggca cctattggtc ttactgacat ccactttgcc      120

tttctctcca cag                                                         133


<210>  69
<211>  210
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  fusion of 5' and 3' nucleotide components of the splice acceptor 
       of the rabbit beta-globulin gene 1

<400>  69
gtgagcgggc gggacggccc ttctcctccg ggctgtaatt agcgcttggt ttaatgacgg       60

cttgtttctt ttctgtggct gcgtgaaagc cttgaggggc tccgggaggc tagagcctct      120

gctaaccatg ttcatgcctt cttctttttc ctacagctcc tgggcaacgt gctggttatt      180

gtgctgtctc atcattttgg caaagaattc                                       210


<210>  70
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal peptide

<400>  70

Met Arg Arg Phe Leu Thr Val Ile Ser Phe Leu Leu Tyr Phe Gly Cys 
1               5                   10                  15      


Ala Phe Ala 
            


<210>  71
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence encoding signal peptide

<400>  71
atgcgccgct tcctgaccgt gatcagcttc ctgctgtact tcggctgcgc cttcgcc          57


<210>  72
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal peptide modified to enhance secretion from target cells

<400>  72

Met Arg Arg Leu Val Leu Leu Leu Cys Ile Gly Ala Leu Leu Gly His 
1               5                   10                  15      


Ser Lys Ala 
            


<210>  73
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence encoding signal peptide modified to enhance
       secretion from target cells

<400>  73
atgcgccgcc tggtgctgct gctgtgcatc ggcgccctgc tgggccacag caaggcc          57


<210>  74
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal peptide

<400>  74

Met Arg Arg Leu Leu Thr Phe Ile Ser Ile Leu Ala 
1               5                   10          


<210>  75
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence encoding signal peptide of SEQ ID NO: 74

<400>  75
atgaagaagc tgctgatcct ggccctggtg ggcgccgccg tggcc                       45


<210>  76
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal peptide

<400>  76

Met Arg Arg Leu Leu Thr Phe Ile Ser Ile Leu Ala Leu Val Gly Ala 
1               5                   10                  15      


Phe Ala 
        


<210>  77
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence encoding signal peptide of SEQ ID NO: 76

<400>  77
atgcgccgcc tgctgacctt catcagcatc ctggccctgg tgggcgcctt cgcc             54


<210>  78
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal peptide

<400>  78

Met Arg Arg Leu Leu Thr Phe Ile Ser Ile Leu Ala Leu Val Gly Ala 
1               5                   10                  15      


Ala Phe Ala 
            


<210>  79
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence encoding signal peptide of SEQ ID NO: 78

<400>  79
atgcgccgcc tgctgacctt catcagcatc ctggccctgg tgggcgccgc cttcgcc          57


<210>  80
<211>  746
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VEGF capture protein-2-furin-P2A-anti-CTGF SCVF-1

<400>  80

Met Arg Arg Leu Leu Thr Phe Ile Ser Ile Leu Ala Leu Val Gly Ala 
1               5                   10                  15      


Ala Phe Ala Ser Asp Thr Gly Arg Pro Phe Val Glu Met Tyr Ser Glu 
            20                  25                  30          


Ile Pro Glu Ile Ile His Met Thr Glu Gly Arg Glu Leu Val Ile Pro 
        35                  40                  45              


Cys Arg Val Thr Ser Pro Asn Ile Thr Val Thr Leu Lys Lys Phe Pro 
    50                  55                  60                  


Leu Asp Thr Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp Asp Ser Arg 
65                  70                  75                  80  


Lys Gly Phe Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile Gly Leu Leu 
                85                  90                  95      


Thr Cys Glu Ala Thr Val Asn Gly His Leu Tyr Lys Thr Asn Tyr Leu 
            100                 105                 110         


Thr His Arg Gln Thr Asn Thr Ile Ile Asp Val Val Leu Ser Pro Ser 
        115                 120                 125             


His Gly Ile Glu Leu Ser Val Gly Glu Lys Leu Val Leu Asn Cys Thr 
    130                 135                 140                 


Ala Arg Thr Glu Leu Asn Val Gly Ile Asp Phe Asn Trp Glu Tyr Pro 
145                 150                 155                 160 


Ser Ser Lys His Gln His Lys Lys Leu Val Asn Arg Asp Leu Lys Thr 
                165                 170                 175     


Gln Ser Gly Ser Glu Met Lys Lys Phe Leu Ser Thr Leu Thr Ile Asp 
            180                 185                 190         


Gly Val Thr Arg Ser Asp Gln Gly Leu Tyr Thr Cys Ala Ala Ser Ser 
        195                 200                 205             


Gly Leu Met Thr Lys Lys Asn Ser Thr Phe Val Arg Val His Glu Lys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu Ala Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn Ala Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Arg Arg Ser Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser 
    450                 455                 460                 


Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Arg 
465                 470                 475                 480 


Arg Phe Leu Thr Val Ile Ser Phe Leu Leu Tyr Phe Gly Cys Ala Phe 
                485                 490                 495     


Ala Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val 
            500                 505                 510         


Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser 
        515                 520                 525             


Trp Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu 
    530                 535                 540                 


Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser 
545                 550                 555                 560 


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
                565                 570                 575     


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro 
            580                 585                 590         


Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Gly Gly Gly 
        595                 600                 605             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    610                 615                 620                 


Gly Ser Glu Gly Gln Leu Val Gln Ser Gly Gly Gly Leu Val His Pro 
625                 630                 635                 640 


Gly Gly Ser Leu Arg Leu Ser Cys Ala Gly Ser Gly Phe Thr Phe Ser 
                645                 650                 655     


Ser Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
            660                 665                 670         


Trp Val Ser Gly Ile Gly Thr Gly Gly Gly Thr Tyr Ser Thr Asp Ser 
        675                 680                 685             


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu 
    690                 695                 700                 


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Met Ala Val Tyr Tyr 
705                 710                 715                 720 


Cys Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Phe Phe Asp Cys Trp 
                725                 730                 735     


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            740                 745     


<210>  81
<211>  2241
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence encoding VEGF capture 
       protein-2-furin-P2A-anti-CTGF SCVF-1

<400>  81
atgcgccgcc tgctgacctt catcagcatc ctggccctgg tgggcgccgc cttcgccagc       60

gacaccggcc gccccttcgt ggagatgtac agcgagatcc ccgagatcat ccacatgacc      120

gagggccgcg agctggtgat cccctgccgc gtgaccagcc ccaacatcac cgtgaccctg      180

aagaagttcc ccctggacac cctgatcccc gacggcaagc gcatcatctg ggacagccgc      240

aagggcttca tcatcagcaa cgccacctac aaggagatcg gcctgctgac ctgcgaggcc      300

accgtgaacg gccacctgta caagaccaac tacctgaccc accgccagac caacaccatc      360

atcgacgtgg tgctgagccc cagccacggc atcgagctga gcgtgggcga gaagctggtg      420

ctgaactgca ccgcccgcac cgagctgaac gtgggcatcg acttcaactg ggagtacccc      480

agcagcaagc accagcacaa gaagctggtg aaccgcgacc tgaagaccca gagcggcagc      540

gagatgaaga agttcctgag caccctgacc atcgacggcg tgacccgcag cgaccagggc      600

ctgtacacct gcgccgccag cagcggcctg atgaccaaga agaacagcac cttcgtgcgc      660

gtgcacgaga aggacaagac ccacacctgc cccccctgcc ccgcccccga ggccgccggc      720

ggccccagcg tgttcctgtt cccccccaag cccaaggaca ccctgatgat cagccgcacc      780

cccgaggtga cctgcgtggt ggtggacgtg agccacgagg accccgaggt gaagttcaac      840

tggtacgtgg acggcgtgga ggtgcacaac gccaagacca agccccgcga ggagcagtac      900

aacagcacct accgcgtggt gagcgtgctg accgtgctgg cccaggactg gctgaacggc      960

aaggagtaca agtgcaaggt gagcaacaag gccctgggcg cccccatcga gaagaccatc     1020

agcaaggcca agggccagcc ccgcgagccc caggtgtaca ccctgccccc cagccgcgac     1080

gagctgacca agaaccaggt gagcctgacc tgcctggtga agggcttcta ccccagcgac     1140

atcgccgtgg agtgggagag caacggccag cccgagaaca actacaagac cacccccccc     1200

gtgctggaca gcgacggcag cttcttcctg tacagcaagc tgaccgtgga caagagccgc     1260

tggcagcagg gcaacgtgtt cagctgcagc gtgatgcacg aggccctgca caacgcctac     1320

acccagaaga gcctgagcct gagccccggc cgccgcagca agcgcagcgg cagcggcgcc     1380

accaacttca gcctgctgaa gcaggccggc gacgtggagg agaaccccgg ccccatgcgc     1440

cgcttcctga ccgtgatcag cttcctgctg tacttcggct gcgccttcgc cgacatccag     1500

atgacccaga gccccagcag cctgagcgcc agcgtgggcg accgcgtgac catcacctgc     1560

cgcgccagcc agggcatcag cagctggctg gcctggtacc agcagaagcc cgagaaggcc     1620

cccaagagcc tgatctacgc cgccagcagc ctccagagcg gcgtgcccag ccgcttcagc     1680

ggcagcggca gcggcaccga cttcaccctg accatcagca gcctccagcc cgaggacttc     1740

gccacctact actgccagca gtacaacagc taccccccca ccttcggcca gggcaccaag     1800

ctggagatca agcgcggcgg cggcggcggc agcggcggcg gcggcagcgg cggcggcggc     1860

agcggcggcg gcggcagcga gggccagctg gtgcagagcg gcggcggcct ggtgcacccc     1920

ggcggcagcc tgcgcctgag ctgcgccggc agcggcttca ccttcagcag ctacggcatg     1980

cactgggtgc gccaggcccc cggcaagggc ctggagtggg tgagcggcat cggcaccggc     2040

ggcggcacct acagcaccga cagcgtgaag ggccgcttca ccatcagccg cgacaacgcc     2100

aagaacagcc tgtacctcca gatgaacagc ctgcgcgccg aggacatggc cgtgtactac     2160

tgcgcccgcg gcgactacta cggcagcggc agcttcttcg actgctgggg ccagggcacc     2220

ctggtgaccg tgagcagcta a                                               2241


<210>  82
<211>  738
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VEGF capture protein-2-furin-P2A-anti-CTGF SCVF-2

<400>  82

Met Arg Arg Leu Leu Thr Phe Ile Ser Ile Leu Ala Leu Val Gly Ala 
1               5                   10                  15      


Ala Phe Ala Ser Asp Thr Gly Arg Pro Phe Val Glu Met Tyr Ser Glu 
            20                  25                  30          


Ile Pro Glu Ile Ile His Met Thr Glu Gly Arg Glu Leu Val Ile Pro 
        35                  40                  45              


Cys Arg Val Thr Ser Pro Asn Ile Thr Val Thr Leu Lys Lys Phe Pro 
    50                  55                  60                  


Leu Asp Thr Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp Asp Ser Arg 
65                  70                  75                  80  


Lys Gly Phe Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile Gly Leu Leu 
                85                  90                  95      


Thr Cys Glu Ala Thr Val Asn Gly His Leu Tyr Lys Thr Asn Tyr Leu 
            100                 105                 110         


Thr His Arg Gln Thr Asn Thr Ile Ile Asp Val Val Leu Ser Pro Ser 
        115                 120                 125             


His Gly Ile Glu Leu Ser Val Gly Glu Lys Leu Val Leu Asn Cys Thr 
    130                 135                 140                 


Ala Arg Thr Glu Leu Asn Val Gly Ile Asp Phe Asn Trp Glu Tyr Pro 
145                 150                 155                 160 


Ser Ser Lys His Gln His Lys Lys Leu Val Asn Arg Asp Leu Lys Thr 
                165                 170                 175     


Gln Ser Gly Ser Glu Met Lys Lys Phe Leu Ser Thr Leu Thr Ile Asp 
            180                 185                 190         


Gly Val Thr Arg Ser Asp Gln Gly Leu Tyr Thr Cys Ala Ala Ser Ser 
        195                 200                 205             


Gly Leu Met Thr Lys Lys Asn Ser Thr Phe Val Arg Val His Glu Lys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu Ala Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn Ala Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Arg Arg Ser Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser 
    450                 455                 460                 


Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Arg 
465                 470                 475                 480 


Arg Phe Leu Thr Val Ile Ser Phe Leu Leu Tyr Phe Gly Cys Ala Phe 
                485                 490                 495     


Ala Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro 
            500                 505                 510         


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp 
        515                 520                 525             


Asp Tyr Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
    530                 535                 540                 


Trp Val Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp 
545                 550                 555                 560 


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser 
                565                 570                 575     


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
            580                 585                 590         


Tyr Cys Ala Arg Gly Ile Thr Glu Thr Trp Gly Gln Gly Thr Leu Val 
        595                 600                 605             


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    610                 615                 620                 


Ser Ala Leu Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr 
625                 630                 635                 640 


Pro Gly Gln Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile 
                645                 650                 655     


Gly Ser Asn Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro 
            660                 665                 670         


Lys Leu Leu Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp 
        675                 680                 685             


Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser 
    690                 695                 700                 


Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp 
705                 710                 715                 720 


Asp Ser Leu Gly Ala Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                725                 730                 735     


Gly Ala 
        


<210>  83
<211>  2217
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence encoding VEGF capture 
       protein-2-furin-P2A-anti-CTGF SCVF-2

<400>  83
atgcgccgcc tgctgacctt catcagcatc ctggccctgg tgggcgccgc cttcgccagc       60

gacaccggcc gccccttcgt ggagatgtac agcgagatcc ccgagatcat ccacatgacc      120

gagggccgcg agctggtgat cccctgccgc gtgaccagcc ccaacatcac cgtgaccctg      180

aagaagttcc ccctggacac cctgatcccc gacggcaagc gcatcatctg ggacagccgc      240

aagggcttca tcatcagcaa cgccacctac aaggagatcg gcctgctgac ctgcgaggcc      300

accgtgaacg gccacctgta caagaccaac tacctgaccc accgccagac caacaccatc      360

atcgacgtgg tgctgagccc cagccacggc atcgagctga gcgtgggcga gaagctggtg      420

ctgaactgca ccgcccgcac cgagctgaac gtgggcatcg acttcaactg ggagtacccc      480

agcagcaagc accagcacaa gaagctggtg aaccgcgacc tgaagaccca gagcggcagc      540

gagatgaaga agttcctgag caccctgacc atcgacggcg tgacccgcag cgaccagggc      600

ctgtacacct gcgccgccag cagcggcctg atgaccaaga agaacagcac cttcgtgcgc      660

gtgcacgaga aggacaagac ccacacctgc cccccctgcc ccgcccccga ggccgccggc      720

ggccccagcg tgttcctgtt cccccccaag cccaaggaca ccctgatgat cagccgcacc      780

cccgaggtga cctgcgtggt ggtggacgtg agccacgagg accccgaggt gaagttcaac      840

tggtacgtgg acggcgtgga ggtgcacaac gccaagacca agccccgcga ggagcagtac      900

aacagcacct accgcgtggt gagcgtgctg accgtgctgg cccaggactg gctgaacggc      960

aaggagtaca agtgcaaggt gagcaacaag gccctgggcg cccccatcga gaagaccatc     1020

agcaaggcca agggccagcc ccgcgagccc caggtgtaca ccctgccccc cagccgcgac     1080

gagctgacca agaaccaggt gagcctgacc tgcctggtga agggcttcta ccccagcgac     1140

atcgccgtgg agtgggagag caacggccag cccgagaaca actacaagac cacccccccc     1200

gtgctggaca gcgacggcag cttcttcctg tacagcaagc tgaccgtgga caagagccgc     1260

tggcagcagg gcaacgtgtt cagctgcagc gtgatgcacg aggccctgca caacgcctac     1320

acccagaaga gcctgagcct gagccccggc cgccgcagca agcgcagcgg cagcggcgcc     1380

accaacttca gcctgctgaa gcaggccggc gacgtggagg agaaccccgg ccccatgcgc     1440

cgcttcctga ccgtgatcag cttcctgctg tacttcggct gcgccttcgc cgccgaggtg     1500

cagctggtgg agagcggcgg cggcgtggtg cggcctggcg gcagcctgcg cctgagctgc     1560

gccgccagcg gcttcacctt cgacgactac ggcatgagct gggtgcgcca ggctccaggc     1620

aagggcctgg agtgggtgag ctacatcagc agcagcggca gcaccatcta ctacgccgac     1680

agcgtgaagg gccgcttcac catcagccgc gacaacgcca agaacagcct gtacctgcag     1740

atgaacagcc tgcgcgccga ggacaccgcc gtgtactact gcgcacgagg catcaccgag     1800

acctggggcc agggcaccct ggtgaccgtg agcagcggcg gcggcggcag cggcggcggc     1860

ggcagcggcg gcagcgccct gcagagcgtg ctgacccagc cacccagcgc cagcggcacc     1920

cctggccagc gcgtgaccat cagctgcagc ggcagcagca gcaacatcgg cagcaacacc     1980

gtgaactggt accagcagct gcccggcacc gcgcctaagc tgctgatcta cagcaacaac     2040

cagcgcccca gcggcgtgcc cgaccgcttc agcggcagca agagcggcac cagcgccagc     2100

ctggccatca gcggcctgca gagcgaggac gaggccgact actactgcgc cgcctgggac     2160

gacagcctgg gcgccgtgtt cggcggcggc accaagctga ccgtgctggg cgcctaa        2217


<210>  84
<211>  739
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VEGF capture protein 2-furin-P2A-anti-C3b SCVF

<400>  84

Met Arg Arg Leu Leu Thr Phe Ile Ser Ile Leu Ala Leu Val Gly Ala 
1               5                   10                  15      


Ala Phe Ala Ser Asp Thr Gly Arg Pro Phe Val Glu Met Tyr Ser Glu 
            20                  25                  30          


Ile Pro Glu Ile Ile His Met Thr Glu Gly Arg Glu Leu Val Ile Pro 
        35                  40                  45              


Cys Arg Val Thr Ser Pro Asn Ile Thr Val Thr Leu Lys Lys Phe Pro 
    50                  55                  60                  


Leu Asp Thr Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp Asp Ser Arg 
65                  70                  75                  80  


Lys Gly Phe Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile Gly Leu Leu 
                85                  90                  95      


Thr Cys Glu Ala Thr Val Asn Gly His Leu Tyr Lys Thr Asn Tyr Leu 
            100                 105                 110         


Thr His Arg Gln Thr Asn Thr Ile Ile Asp Val Val Leu Ser Pro Ser 
        115                 120                 125             


His Gly Ile Glu Leu Ser Val Gly Glu Lys Leu Val Leu Asn Cys Thr 
    130                 135                 140                 


Ala Arg Thr Glu Leu Asn Val Gly Ile Asp Phe Asn Trp Glu Tyr Pro 
145                 150                 155                 160 


Ser Ser Lys His Gln His Lys Lys Leu Val Asn Arg Asp Leu Lys Thr 
                165                 170                 175     


Gln Ser Gly Ser Glu Met Lys Lys Phe Leu Ser Thr Leu Thr Ile Asp 
            180                 185                 190         


Gly Val Thr Arg Ser Asp Gln Gly Leu Tyr Thr Cys Ala Ala Ser Ser 
        195                 200                 205             


Gly Leu Met Thr Lys Lys Asn Ser Thr Phe Val Arg Val His Glu Lys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu Ala Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn Ala Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Arg Arg Ser Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser 
    450                 455                 460                 


Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Arg 
465                 470                 475                 480 


Arg Phe Leu Thr Val Ile Ser Phe Leu Leu Tyr Phe Gly Cys Ala Phe 
                485                 490                 495     


Ala Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val 
            500                 505                 510         


Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr 
        515                 520                 525             


Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
    530                 535                 540                 


Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser 
545                 550                 555                 560 


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
                565                 570                 575     


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ala Thr Leu 
            580                 585                 590         


Pro Thr Phe Glu Gln Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Gly 
        595                 600                 605             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    610                 615                 620                 


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
625                 630                 635                 640 


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Thr 
                645                 650                 655     


Ser Ser Ser Val Ser Pro Gly Lys Gly Leu Glu Trp Val Gly Leu Ile 
            660                 665                 670         


Tyr Pro Tyr Asn Gly Phe Asn Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
        675                 680                 685             


Phe Thr Ile Ser Ala Asp Thr Ser Leu Gln Met Asn Ser Leu Arg Ala 
    690                 695                 700                 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asn Ala Leu Tyr Gly Ser 
705                 710                 715                 720 


Gly Gly Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
                725                 730                 735     


Val Ser Ser 
            


<210>  85
<211>  2220
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence encoding VEGF capture protein 
       2-furin-P2A-anti-C3b SCVF

<400>  85
atgcgccgcc tgctgacctt catcagcatc ctggccctgg tgggcgccgc cttcgccagc       60

gacaccggcc gccccttcgt ggagatgtac agcgagatcc ccgagatcat ccacatgacc      120

gagggccgcg agctggtgat cccctgccgc gtgaccagcc ccaacatcac cgtgaccctg      180

aagaagttcc ccctggacac cctgatcccc gacggcaagc gcatcatctg ggacagccgc      240

aagggcttca tcatcagcaa cgccacctac aaggagatcg gcctgctgac ctgcgaggcc      300

accgtgaacg gccacctgta caagaccaac tacctgaccc accgccagac caacaccatc      360

atcgacgtgg tgctgagccc cagccacggc atcgagctga gcgtgggcga gaagctggtg      420

ctgaactgca ccgcccgcac cgagctgaac gtgggcatcg acttcaactg ggagtacccc      480

agcagcaagc accagcacaa gaagctggtg aaccgcgacc tgaagaccca gagcggcagc      540

gagatgaaga agttcctgag caccctgacc atcgacggcg tgacccgcag cgaccagggc      600

ctgtacacct gcgccgccag cagcggcctg atgaccaaga agaacagcac cttcgtgcgc      660

gtgcacgaga aggacaagac ccacacctgc cccccctgcc ccgcccccga ggccgccggc      720

ggccccagcg tgttcctgtt cccccccaag cccaaggaca ccctgatgat cagccgcacc      780

cccgaggtga cctgcgtggt ggtggacgtg agccacgagg accccgaggt gaagttcaac      840

tggtacgtgg acggcgtgga ggtgcacaac gccaagacca agccccgcga ggagcagtac      900

aacagcacct accgcgtggt gagcgtgctg accgtgctgg cccaggactg gctgaacggc      960

aaggagtaca agtgcaaggt gagcaacaag gccctgggcg cccccatcga gaagaccatc     1020

agcaaggcca agggccagcc ccgcgagccc caggtgtaca ccctgccccc cagccgcgac     1080

gagctgacca agaaccaggt gagcctgacc tgcctggtga agggcttcta ccccagcgac     1140

atcgccgtgg agtgggagag caacggccag cccgagaaca actacaagac cacccccccc     1200

gtgctggaca gcgacggcag cttcttcctg tacagcaagc tgaccgtgga caagagccgc     1260

tggcagcagg gcaacgtgtt cagctgcagc gtgatgcacg aggccctgca caacgcctac     1320

acccagaaga gcctgagcct gagccccggc cgccgcagca agcgcagcgg cagcggcgcc     1380

accaacttca gcctgctgaa gcaggccggc gacgtggagg agaaccccgg ccccatgcgc     1440

cgcttcctga ccgtgatcag cttcctgctg tacttcggct gcgccttcgc cgacatccag     1500

atgacccaga gccccagcag cctgagcgcc agcgtgggcg accgcgtgac catcacctgc     1560

cgcgccagcc aggacgtaag caccgccgtg gcctggtacc agcagaagcc cggcaaggcc     1620

cccaagctgc tgatctacag cgccagcttc ctgtacagcg gcgtgcccag ccgcttcagc     1680

ggcagcggca gcggcaccga cttcaccctg accatcagca gcctgcagcc cgaggacttc     1740

gccacctact actgccagca gagctacgcc accctgccca ccttcgagca gggcaccaag     1800

gtggagatca agcgcggcgg cggcggcggc agcggcggcg gcggcagcgg cggcggcggc     1860

agcggcggcg gcggcagcga ggtgcagctg gtggagagcg gcggcggcct ggtgcagccc     1920

ggcggcagcc tgcgcctgag ctgcgccgcc agcggcttca gcttcaccag cagcagcgtg     1980

agccccggca agggcctgga gtgggtgggc ctgatctacc cctacaacgg cttcaactac     2040

tacgccgaca gcgtgaaggg ccgcttcacc atcagcgccg acaccagcct gcagatgaac     2100

agcctgcgcg ccgaggacac cgccgtgtac tactgcgccc gcaacgccct gtacggcagc     2160

ggcggctact acgccatgga ctactggggc cagggcaccc tggtgaccgt gagcagctga     2220


<210>  86
<211>  747
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VEGF capture protein 2-furin-P2A-anti-Bb SCVF

<400>  86

Met Arg Arg Leu Leu Thr Phe Ile Ser Ile Leu Ala Leu Val Gly Ala 
1               5                   10                  15      


Ala Phe Ala Ser Asp Thr Gly Arg Pro Phe Val Glu Met Tyr Ser Glu 
            20                  25                  30          


Ile Pro Glu Ile Ile His Met Thr Glu Gly Arg Glu Leu Val Ile Pro 
        35                  40                  45              


Cys Arg Val Thr Ser Pro Asn Ile Thr Val Thr Leu Lys Lys Phe Pro 
    50                  55                  60                  


Leu Asp Thr Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp Asp Ser Arg 
65                  70                  75                  80  


Lys Gly Phe Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile Gly Leu Leu 
                85                  90                  95      


Thr Cys Glu Ala Thr Val Asn Gly His Leu Tyr Lys Thr Asn Tyr Leu 
            100                 105                 110         


Thr His Arg Gln Thr Asn Thr Ile Ile Asp Val Val Leu Ser Pro Ser 
        115                 120                 125             


His Gly Ile Glu Leu Ser Val Gly Glu Lys Leu Val Leu Asn Cys Thr 
    130                 135                 140                 


Ala Arg Thr Glu Leu Asn Val Gly Ile Asp Phe Asn Trp Glu Tyr Pro 
145                 150                 155                 160 


Ser Ser Lys His Gln His Lys Lys Leu Val Asn Arg Asp Leu Lys Thr 
                165                 170                 175     


Gln Ser Gly Ser Glu Met Lys Lys Phe Leu Ser Thr Leu Thr Ile Asp 
            180                 185                 190         


Gly Val Thr Arg Ser Asp Gln Gly Leu Tyr Thr Cys Ala Ala Ser Ser 
        195                 200                 205             


Gly Leu Met Thr Lys Lys Asn Ser Thr Phe Val Arg Val His Glu Lys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu Ala Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn Ala Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Arg Arg Ser Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser 
    450                 455                 460                 


Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Arg 
465                 470                 475                 480 


Arg Phe Leu Thr Val Ile Ser Phe Leu Leu Tyr Phe Gly Cys Ala Phe 
                485                 490                 495     


Ala Asp Val Gln Ile Thr Gln Ser Pro Ser Tyr Leu Ala Ala Ser Pro 
            500                 505                 510         


Gly Glu Thr Ile Thr Ile Asn Cys Arg Ala Ser Lys Ser Ile Ser Lys 
        515                 520                 525             


Tyr Leu Ala Trp Tyr Gln Asp Lys Pro Gly Lys Thr Asn Lys Leu Leu 
    530                 535                 540                 


Ile Tyr Ser Gly Ser Thr Leu Gln Ser Gly Ile Pro Ser Arg Phe Ser 
545                 550                 555                 560 


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 
                565                 570                 575     


Pro Glu Asp Phe Ala Met Tyr Tyr Cys Gln Gln His Asp Glu Tyr Pro 
            580                 585                 590         


Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Gly Gly Gly 
        595                 600                 605             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    610                 615                 620                 


Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Lys Pro 
625                 630                 635                 640 


Gly Ala Ser Val Arg Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
                645                 650                 655     


Asn Tyr Trp Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu 
            660                 665                 670         


Trp Ile Gly Tyr Ile Asn Pro Asn Thr Gly Tyr Asn Asp Tyr Asn Gln 
        675                 680                 685             


Lys Phe Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr 
    690                 695                 700                 


Val Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
705                 710                 715                 720 


Tyr Cys Ala Arg Gly Gly Gln Leu Gly Leu Arg Arg Ala Met Asp Tyr 
                725                 730                 735     


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
            740                 745         


<210>  87
<211>  2244
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence encoding VEGF capture protein 
       2-furin-P2A-anti-Bb SCVF

<400>  87
atgcgccgcc tgctgacctt catcagcatc ctggccctgg tgggcgccgc cttcgccagc       60

gacaccggcc gccccttcgt ggagatgtac agcgagatcc ccgagatcat ccacatgacc      120

gagggccgcg agctggtgat cccctgccgc gtgaccagcc ccaacatcac cgtgaccctg      180

aagaagttcc ccctggacac cctgatcccc gacggcaagc gcatcatctg ggacagccgc      240

aagggcttca tcatcagcaa cgccacctac aaggagatcg gcctgctgac ctgcgaggcc      300

accgtgaacg gccacctgta caagaccaac tacctgaccc accgccagac caacaccatc      360

atcgacgtgg tgctgagccc cagccacggc atcgagctga gcgtgggcga gaagctggtg      420

ctgaactgca ccgcccgcac cgagctgaac gtgggcatcg acttcaactg ggagtacccc      480

agcagcaagc accagcacaa gaagctggtg aaccgcgacc tgaagaccca gagcggcagc      540

gagatgaaga agttcctgag caccctgacc atcgacggcg tgacccgcag cgaccagggc      600

ctgtacacct gcgccgccag cagcggcctg atgaccaaga agaacagcac cttcgtgcgc      660

gtgcacgaga aggacaagac ccacacctgc cccccctgcc ccgcccccga ggccgccggc      720

ggccccagcg tgttcctgtt cccccccaag cccaaggaca ccctgatgat cagccgcacc      780

cccgaggtga cctgcgtggt ggtggacgtg agccacgagg accccgaggt gaagttcaac      840

tggtacgtgg acggcgtgga ggtgcacaac gccaagacca agccccgcga ggagcagtac      900

aacagcacct accgcgtggt gagcgtgctg accgtgctgg cccaggactg gctgaacggc      960

aaggagtaca agtgcaaggt gagcaacaag gccctgggcg cccccatcga gaagaccatc     1020

agcaaggcca agggccagcc ccgcgagccc caggtgtaca ccctgccccc cagccgcgac     1080

gagctgacca agaaccaggt gagcctgacc tgcctggtga agggcttcta ccccagcgac     1140

atcgccgtgg agtgggagag caacggccag cccgagaaca actacaagac cacccccccc     1200

gtgctggaca gcgacggcag cttcttcctg tacagcaagc tgaccgtgga caagagccgc     1260

tggcagcagg gcaacgtgtt cagctgcagc gtgatgcacg aggccctgca caacgcctac     1320

acccagaaga gcctgagcct gagccccggc cgccgcagca agcgcagcgg cagcggcgcc     1380

accaacttca gcctgctgaa gcaggccggc gacgtggagg agaaccccgg ccccatgcgc     1440

cgcttcctga ccgtgatcag cttcctgctg tacttcggct gcgccttcgc cgacgtgcag     1500

atcacccaga gccccagcta cctggccgcc agccccggcg agaccatcac catcaactgc     1560

cgcgccagca agagcatcag caagtacctg gcctggtacc aggacaagcc cggcaagacc     1620

aacaagctgc tgatctacag cggcagcacc ctgcagagcg gcatccccag ccgcttcagc     1680

ggcagcggca gcggcaccga cttcaccctg accatcagca gcctggagcc cgaggacttc     1740

gccatgtact actgccagca gcacgacgag tacccctgga ccttcggcgg cggcaccaag     1800

ctggagatca agcgcggcgg cggcggcggc agcggcggcg gcggcagcgg cggcggcggc     1860

agcggcggcg gcggcagcca ggtgcagctg cagcagagcg gcgccgagct ggccaagccc     1920

ggcgccagcg tgcgcatgag ctgcaaggcc agcggctaca ccttcaccaa ctactggatc     1980

cactgggtga agcagcgccc cggccagggc ctggagtgga tcggctacat caaccccaac     2040

accggctaca acgactacaa ccagaagttc aaggacaagg ccaccctgac cgccgacaag     2100

agcagcagca ccgtgtacat gcagctgagc agcctgacca gcgaggacag cgccgtgtac     2160

tactgcgccc gcggcggcca gctgggcctg cgccgcgcca tggactactg gggccagggc     2220

accagcgtga ccgtgagcag ctga                                            2244


<210>  88
<211>  817
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VEGF capture protein 2-furin-P2A-sCD55

<400>  88

Met Arg Arg Leu Leu Thr Phe Ile Ser Ile Leu Ala Leu Val Gly Ala 
1               5                   10                  15      


Ala Phe Ala Ser Asp Thr Gly Arg Pro Phe Val Glu Met Tyr Ser Glu 
            20                  25                  30          


Ile Pro Glu Ile Ile His Met Thr Glu Gly Arg Glu Leu Val Ile Pro 
        35                  40                  45              


Cys Arg Val Thr Ser Pro Asn Ile Thr Val Thr Leu Lys Lys Phe Pro 
    50                  55                  60                  


Leu Asp Thr Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp Asp Ser Arg 
65                  70                  75                  80  


Lys Gly Phe Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile Gly Leu Leu 
                85                  90                  95      


Thr Cys Glu Ala Thr Val Asn Gly His Leu Tyr Lys Thr Asn Tyr Leu 
            100                 105                 110         


Thr His Arg Gln Thr Asn Thr Ile Ile Asp Val Val Leu Ser Pro Ser 
        115                 120                 125             


His Gly Ile Glu Leu Ser Val Gly Glu Lys Leu Val Leu Asn Cys Thr 
    130                 135                 140                 


Ala Arg Thr Glu Leu Asn Val Gly Ile Asp Phe Asn Trp Glu Tyr Pro 
145                 150                 155                 160 


Ser Ser Lys His Gln His Lys Lys Leu Val Asn Arg Asp Leu Lys Thr 
                165                 170                 175     


Gln Ser Gly Ser Glu Met Lys Lys Phe Leu Ser Thr Leu Thr Ile Asp 
            180                 185                 190         


Gly Val Thr Arg Ser Asp Gln Gly Leu Tyr Thr Cys Ala Ala Ser Ser 
        195                 200                 205             


Gly Leu Met Thr Lys Lys Asn Ser Thr Phe Val Arg Val His Glu Lys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu Ala Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn Ala Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Arg Arg Ser Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser 
    450                 455                 460                 


Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Arg 
465                 470                 475                 480 


Arg Phe Leu Thr Val Ile Ser Phe Leu Leu Tyr Phe Gly Cys Ala Phe 
                485                 490                 495     


Ala Asp Cys Gly Leu Pro Pro Asp Val Pro Asn Ala Gln Pro Ala Leu 
            500                 505                 510         


Glu Gly Arg Thr Ser Phe Pro Glu Asp Thr Val Ile Thr Tyr Lys Cys 
        515                 520                 525             


Glu Glu Ser Phe Val Lys Ile Pro Gly Glu Lys Asp Ser Val Ile Cys 
    530                 535                 540                 


Leu Lys Gly Ser Gln Trp Ser Asp Ile Glu Glu Phe Cys Asn Arg Ser 
545                 550                 555                 560 


Cys Glu Val Pro Thr Arg Leu Asn Ser Ala Ser Leu Lys Gln Pro Tyr 
                565                 570                 575     


Ile Thr Gln Asn Tyr Phe Pro Val Gly Thr Val Val Glu Tyr Glu Cys 
            580                 585                 590         


Arg Pro Gly Tyr Arg Arg Glu Pro Ser Leu Ser Pro Lys Leu Thr Cys 
        595                 600                 605             


Leu Gln Asn Leu Lys Trp Ser Thr Ala Val Glu Phe Cys Lys Lys Lys 
    610                 615                 620                 


Ser Cys Pro Asn Pro Gly Glu Ile Arg Asn Gly Gln Ile Asp Val Pro 
625                 630                 635                 640 


Gly Gly Ile Leu Phe Gly Ala Thr Ile Ser Phe Ser Cys Asn Thr Gly 
                645                 650                 655     


Tyr Lys Leu Phe Gly Ser Thr Ser Ser Phe Cys Leu Ile Ser Gly Ser 
            660                 665                 670         


Ser Val Gln Trp Ser Asp Pro Leu Pro Glu Cys Arg Glu Ile Tyr Cys 
        675                 680                 685             


Pro Ala Pro Pro Gln Ile Asp Asn Gly Ile Ile Gln Gly Glu Arg Asp 
    690                 695                 700                 


His Tyr Gly Tyr Arg Gln Ser Val Thr Tyr Ala Cys Asn Lys Gly Phe 
705                 710                 715                 720 


Thr Met Ile Gly Glu His Ser Ile Tyr Cys Thr Val Asn Asn Asp Glu 
                725                 730                 735     


Gly Glu Trp Ser Gly Pro Pro Pro Glu Cys Arg Gly Lys Ser Leu Thr 
            740                 745                 750         


Ser Lys Val Pro Pro Thr Val Gln Lys Pro Thr Thr Val Asn Val Pro 
        755                 760                 765             


Thr Thr Glu Val Ser Pro Thr Ser Gln Lys Thr Thr Thr Lys Thr Thr 
    770                 775                 780                 


Thr Pro Asn Ala Gln Ala Thr Arg Ser Thr Pro Val Ser Arg Thr Thr 
785                 790                 795                 800 


Lys His Phe His Glu Thr Thr Pro Asn Lys Gly Ser Gly Thr Thr Ser 
                805                 810                 815     


Gly 
    


<210>  89
<211>  2454
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence encoding VEGF capture protein 
       2-furin-P2A-sCD55

<400>  89
atgcgccgcc tgctgacctt catcagcatc ctggccctgg tgggcgccgc cttcgccagc       60

gacaccggcc gccccttcgt ggagatgtac agcgagatcc ccgagatcat ccacatgacc      120

gagggccgcg agctggtgat cccctgccgc gtgaccagcc ccaacatcac cgtgaccctg      180

aagaagttcc ccctggacac cctgatcccc gacggcaagc gcatcatctg ggacagccgc      240

aagggcttca tcatcagcaa cgccacctac aaggagatcg gcctgctgac ctgcgaggcc      300

accgtgaacg gccacctgta caagaccaac tacctgaccc accgccagac caacaccatc      360

atcgacgtgg tgctgagccc cagccacggc atcgagctga gcgtgggcga gaagctggtg      420

ctgaactgca ccgcccgcac cgagctgaac gtgggcatcg acttcaactg ggagtacccc      480

agcagcaagc accagcacaa gaagctggtg aaccgcgacc tgaagaccca gagcggcagc      540

gagatgaaga agttcctgag caccctgacc atcgacggcg tgacccgcag cgaccagggc      600

ctgtacacct gcgccgccag cagcggcctg atgaccaaga agaacagcac cttcgtgcgc      660

gtgcacgaga aggacaagac ccacacctgc cccccctgcc ccgcccccga ggccgccggc      720

ggccccagcg tgttcctgtt cccccccaag cccaaggaca ccctgatgat cagccgcacc      780

cccgaggtga cctgcgtggt ggtggacgtg agccacgagg accccgaggt gaagttcaac      840

tggtacgtgg acggcgtgga ggtgcacaac gccaagacca agccccgcga ggagcagtac      900

aacagcacct accgcgtggt gagcgtgctg accgtgctgg cccaggactg gctgaacggc      960

aaggagtaca agtgcaaggt gagcaacaag gccctgggcg cccccatcga gaagaccatc     1020

agcaaggcca agggccagcc ccgcgagccc caggtgtaca ccctgccccc cagccgcgac     1080

gagctgacca agaaccaggt gagcctgacc tgcctggtga agggcttcta ccccagcgac     1140

atcgccgtgg agtgggagag caacggccag cccgagaaca actacaagac cacccccccc     1200

gtgctggaca gcgacggcag cttcttcctg tacagcaagc tgaccgtgga caagagccgc     1260

tggcagcagg gcaacgtgtt cagctgcagc gtgatgcacg aggccctgca caacgcctac     1320

acccagaaga gcctgagcct gagccccggc cgccgcagca agcgcagcgg cagcggcgcc     1380

accaacttca gcctgctgaa gcaggccggc gacgtggagg agaaccccgg ccccatgcgc     1440

cgcttcctga ccgtgatcag cttcctgctg tacttcggct gcgccttcgc cgactgcggc     1500

ctgccccccg acgtgcccaa cgcccagccc gccctggagg gccgcaccag cttccccgag     1560

gacaccgtga tcacctacaa gtgcgaggag agcttcgtga agatccccgg cgagaaggac     1620

agcgtgatct gcctgaaggg cagccagtgg agcgacatcg aggagttctg caaccgcagc     1680

tgcgaggtgc ccacccgcct gaacagcgcc agcctgaagc agccctacat cacccagaac     1740

tacttccccg tgggcaccgt ggtggagtac gagtgccgcc ccggctaccg ccgcgagccc     1800

agcctgagcc ccaagctgac ctgcctgcag aacctgaagt ggagcaccgc cgtggagttc     1860

tgcaagaaga agagctgccc caaccccggc gagatccgca acggccagat cgacgtgccc     1920

ggcggcatcc tgttcggcgc caccatcagc ttcagctgca acaccggcta caagctgttc     1980

ggcagcacca gcagcttctg cctgatcagc ggcagcagcg tgcagtggag cgaccccctg     2040

cccgagtgcc gcgagatcta ctgccccgcc cccccccaga tcgacaacgg catcatccag     2100

ggcgagcgcg accactacgg ctaccgccag agcgtgacct acgcctgcaa caagggcttc     2160

accatgatcg gcgagcacag catctactgc accgtgaaca acgacgaggg cgagtggagc     2220

ggcccccccc ccgagtgccg aggcaagagc ctgaccagca aggtgccccc caccgtgcag     2280

aagcccacca ccgtgaacgt gcccaccacc gaggtgagcc ccaccagcca gaagaccacc     2340

accaagacca ccacccccaa cgcccaggcc acccgcagca cccccgtgag ccgcaccacc     2400

aagcacttcc acgagaccac ccccaacaag ggcagcggca ccaccagcgg ctaa           2454


<210>  90
<211>  817
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sCD55-furin-P2A- VEGF capture protein 2

<400>  90

Met Arg Arg Phe Leu Thr Val Ile Ser Phe Leu Leu Tyr Phe Gly Cys 
1               5                   10                  15      


Ala Phe Ala Asp Cys Gly Leu Pro Pro Asp Val Pro Asn Ala Gln Pro 
            20                  25                  30          


Ala Leu Glu Gly Arg Thr Ser Phe Pro Glu Asp Thr Val Ile Thr Tyr 
        35                  40                  45              


Lys Cys Glu Glu Ser Phe Val Lys Ile Pro Gly Glu Lys Asp Ser Val 
    50                  55                  60                  


Ile Cys Leu Lys Gly Ser Gln Trp Ser Asp Ile Glu Glu Phe Cys Asn 
65                  70                  75                  80  


Arg Ser Cys Glu Val Pro Thr Arg Leu Asn Ser Ala Ser Leu Lys Gln 
                85                  90                  95      


Pro Tyr Ile Thr Gln Asn Tyr Phe Pro Val Gly Thr Val Val Glu Tyr 
            100                 105                 110         


Glu Cys Arg Pro Gly Tyr Arg Arg Glu Pro Ser Leu Ser Pro Lys Leu 
        115                 120                 125             


Thr Cys Leu Gln Asn Leu Lys Trp Ser Thr Ala Val Glu Phe Cys Lys 
    130                 135                 140                 


Lys Lys Ser Cys Pro Asn Pro Gly Glu Ile Arg Asn Gly Gln Ile Asp 
145                 150                 155                 160 


Val Pro Gly Gly Ile Leu Phe Gly Ala Thr Ile Ser Phe Ser Cys Asn 
                165                 170                 175     


Thr Gly Tyr Lys Leu Phe Gly Ser Thr Ser Ser Phe Cys Leu Ile Ser 
            180                 185                 190         


Gly Ser Ser Val Gln Trp Ser Asp Pro Leu Pro Glu Cys Arg Glu Ile 
        195                 200                 205             


Tyr Cys Pro Ala Pro Pro Gln Ile Asp Asn Gly Ile Ile Gln Gly Glu 
    210                 215                 220                 


Arg Asp His Tyr Gly Tyr Arg Gln Ser Val Thr Tyr Ala Cys Asn Lys 
225                 230                 235                 240 


Gly Phe Thr Met Ile Gly Glu His Ser Ile Tyr Cys Thr Val Asn Asn 
                245                 250                 255     


Asp Glu Gly Glu Trp Ser Gly Pro Pro Pro Glu Cys Arg Gly Lys Ser 
            260                 265                 270         


Leu Thr Ser Lys Val Pro Pro Thr Val Gln Lys Pro Thr Thr Val Asn 
        275                 280                 285             


Val Pro Thr Thr Glu Val Ser Pro Thr Ser Gln Lys Thr Thr Thr Lys 
    290                 295                 300                 


Thr Thr Thr Pro Asn Ala Gln Ala Thr Arg Ser Thr Pro Val Ser Arg 
305                 310                 315                 320 


Thr Thr Lys His Phe His Glu Thr Thr Pro Asn Lys Gly Ser Gly Thr 
                325                 330                 335     


Thr Ser Gly Arg Arg Ser Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe 
            340                 345                 350         


Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met 
        355                 360                 365             


Arg Arg Leu Leu Thr Phe Ile Ser Ile Leu Ala Leu Val Gly Ala Ala 
    370                 375                 380                 


Phe Ala Ser Asp Thr Gly Arg Pro Phe Val Glu Met Tyr Ser Glu Ile 
385                 390                 395                 400 


Pro Glu Ile Ile His Met Thr Glu Gly Arg Glu Leu Val Ile Pro Cys 
                405                 410                 415     


Arg Val Thr Ser Pro Asn Ile Thr Val Thr Leu Lys Lys Phe Pro Leu 
            420                 425                 430         


Asp Thr Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp Asp Ser Arg Lys 
        435                 440                 445             


Gly Phe Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile Gly Leu Leu Thr 
    450                 455                 460                 


Cys Glu Ala Thr Val Asn Gly His Leu Tyr Lys Thr Asn Tyr Leu Thr 
465                 470                 475                 480 


His Arg Gln Thr Asn Thr Ile Ile Asp Val Val Leu Ser Pro Ser His 
                485                 490                 495     


Gly Ile Glu Leu Ser Val Gly Glu Lys Leu Val Leu Asn Cys Thr Ala 
            500                 505                 510         


Arg Thr Glu Leu Asn Val Gly Ile Asp Phe Asn Trp Glu Tyr Pro Ser 
        515                 520                 525             


Ser Lys His Gln His Lys Lys Leu Val Asn Arg Asp Leu Lys Thr Gln 
    530                 535                 540                 


Ser Gly Ser Glu Met Lys Lys Phe Leu Ser Thr Leu Thr Ile Asp Gly 
545                 550                 555                 560 


Val Thr Arg Ser Asp Gln Gly Leu Tyr Thr Cys Ala Ala Ser Ser Gly 
                565                 570                 575     


Leu Met Thr Lys Lys Asn Ser Thr Phe Val Arg Val His Glu Lys Asp 
            580                 585                 590         


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly 
        595                 600                 605             


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
    610                 615                 620                 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
625                 630                 635                 640 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
                645                 650                 655     


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
            660                 665                 670         


Val Val Ser Val Leu Thr Val Leu Ala Gln Asp Trp Leu Asn Gly Lys 
        675                 680                 685             


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu 
    690                 695                 700                 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
705                 710                 715                 720 


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
                725                 730                 735     


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
            740                 745                 750         


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
        755                 760                 765             


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
    770                 775                 780                 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
785                 790                 795                 800 


Glu Ala Leu His Asn Ala Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
                805                 810                 815     


Gly 
    


<210>  91
<211>  2454
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence encoding sCD55-furin-P2A- VEGF capture 
       protein 2

<400>  91
atgcgccgct tcctgaccgt gatcagcttc ctgctgtact tcggctgcgc cttcgccgac       60

tgcggcctgc cccccgacgt gcccaacgcc cagcccgccc tggagggccg caccagcttc      120

cccgaggaca ccgtgatcac ctacaagtgc gaggagagct tcgtgaagat ccccggcgag      180

aaggacagcg tgatctgcct gaagggcagc cagtggagcg acatcgagga gttctgcaac      240

cgcagctgcg aggtgcccac ccgcctgaac agcgccagcc tgaagcagcc ctacatcacc      300

cagaactact tccccgtggg caccgtggtg gagtacgagt gccgccccgg ctaccgccgc      360

gagcccagcc tgagccccaa gctgacctgc ctgcagaacc tgaagtggag caccgccgtg      420

gagttctgca agaagaagag ctgccccaac cccggcgaga tccgcaacgg ccagatcgac      480

gtgcccggcg gcatcctgtt cggcgccacc atcagcttca gctgcaacac cggctacaag      540

ctgttcggca gcaccagcag cttctgcctg atcagcggca gcagcgtgca gtggagcgac      600

cccctgcccg agtgccgcga gatctactgc cccgcccccc cccagatcga caacggcatc      660

atccagggcg agcgcgacca ctacggctac cgccagagcg tgacctacgc ctgcaacaag      720

ggcttcacca tgatcggcga gcacagcatc tactgcaccg tgaacaacga cgagggcgag      780

tggagcggcc ccccccccga gtgccgaggc aagagcctga ccagcaaggt gccccccacc      840

gtgcagaagc ccaccaccgt gaacgtgccc accaccgagg tgagccccac cagccagaag      900

accaccacca agaccaccac ccccaacgcc caggccaccc gcagcacccc cgtgagccgc      960

accaccaagc acttccacga gaccaccccc aacaagggca gcggcaccac cagcggccgc     1020

cgcagcaagc gcagcggcag cggcgccacc aacttcagcc tgctgaagca ggccggcgac     1080

gtggaggaga accccggccc catgcgccgc ctgctgacct tcatcagcat cctggccctg     1140

gtgggcgccg ccttcgccag cgacaccggc cgccccttcg tggagatgta cagcgagatc     1200

cccgagatca tccacatgac cgagggccgc gagctggtga tcccctgccg cgtgaccagc     1260

cccaacatca ccgtgaccct gaagaagttc cccctggaca ccctgatccc cgacggcaag     1320

cgcatcatct gggacagccg caagggcttc atcatcagca acgccaccta caaggagatc     1380

ggcctgctga cctgcgaggc caccgtgaac ggccacctgt acaagaccaa ctacctgacc     1440

caccgccaga ccaacaccat catcgacgtg gtgctgagcc ccagccacgg catcgagctg     1500

agcgtgggcg agaagctggt gctgaactgc accgcccgca ccgagctgaa cgtgggcatc     1560

gacttcaact gggagtaccc cagcagcaag caccagcaca agaagctggt gaaccgcgac     1620

ctgaagaccc agagcggcag cgagatgaag aagttcctga gcaccctgac catcgacggc     1680

gtgacccgca gcgaccaggg cctgtacacc tgcgccgcca gcagcggcct gatgaccaag     1740

aagaacagca ccttcgtgcg cgtgcacgag aaggacaaga cccacacctg ccccccctgc     1800

cccgcccccg aggccgccgg cggccccagc gtgttcctgt tcccccccaa gcccaaggac     1860

accctgatga tcagccgcac ccccgaggtg acctgcgtgg tggtggacgt gagccacgag     1920

gaccccgagg tgaagttcaa ctggtacgtg gacggcgtgg aggtgcacaa cgccaagacc     1980

aagccccgcg aggagcagta caacagcacc taccgcgtgg tgagcgtgct gaccgtgctg     2040

gcccaggact ggctgaacgg caaggagtac aagtgcaagg tgagcaacaa ggccctgggc     2100

gcccccatcg agaagaccat cagcaaggcc aagggccagc cccgcgagcc ccaggtgtac     2160

accctgcccc ccagccgcga cgagctgacc aagaaccagg tgagcctgac ctgcctggtg     2220

aagggcttct accccagcga catcgccgtg gagtgggaga gcaacggcca gcccgagaac     2280

aactacaaga ccaccccccc cgtgctggac agcgacggca gcttcttcct gtacagcaag     2340

ctgaccgtgg acaagagccg ctggcagcag ggcaacgtgt tcagctgcag cgtgatgcac     2400

gaggccctgc acaacgccta cacccagaag agcctgagcc tgagccccgg ctaa           2454


<210>  92
<211>  809
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VEGF capture protein 2 -furin-P2A- CFHR1

<400>  92

Met Arg Arg Leu Leu Thr Phe Ile Ser Ile Leu Ala Leu Val Gly Ala 
1               5                   10                  15      


Ala Phe Ala Ser Asp Thr Gly Arg Pro Phe Val Glu Met Tyr Ser Glu 
            20                  25                  30          


Ile Pro Glu Ile Ile His Met Thr Glu Gly Arg Glu Leu Val Ile Pro 
        35                  40                  45              


Cys Arg Val Thr Ser Pro Asn Ile Thr Val Thr Leu Lys Lys Phe Pro 
    50                  55                  60                  


Leu Asp Thr Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp Asp Ser Arg 
65                  70                  75                  80  


Lys Gly Phe Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile Gly Leu Leu 
                85                  90                  95      


Thr Cys Glu Ala Thr Val Asn Gly His Leu Tyr Lys Thr Asn Tyr Leu 
            100                 105                 110         


Thr His Arg Gln Thr Asn Thr Ile Ile Asp Val Val Leu Ser Pro Ser 
        115                 120                 125             


His Gly Ile Glu Leu Ser Val Gly Glu Lys Leu Val Leu Asn Cys Thr 
    130                 135                 140                 


Ala Arg Thr Glu Leu Asn Val Gly Ile Asp Phe Asn Trp Glu Tyr Pro 
145                 150                 155                 160 


Ser Ser Lys His Gln His Lys Lys Leu Val Asn Arg Asp Leu Lys Thr 
                165                 170                 175     


Gln Ser Gly Ser Glu Met Lys Lys Phe Leu Ser Thr Leu Thr Ile Asp 
            180                 185                 190         


Gly Val Thr Arg Ser Asp Gln Gly Leu Tyr Thr Cys Ala Ala Ser Ser 
        195                 200                 205             


Gly Leu Met Thr Lys Lys Asn Ser Thr Phe Val Arg Val His Glu Lys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu Ala Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn Ala Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Arg Arg Ser Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser 
    450                 455                 460                 


Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Arg 
465                 470                 475                 480 


Arg Phe Leu Thr Val Ile Ser Phe Leu Leu Tyr Phe Gly Cys Ala Phe 
                485                 490                 495     


Ala Glu Ala Thr Phe Cys Asp Phe Pro Lys Ile Asn His Gly Ile Leu 
            500                 505                 510         


Tyr Asp Glu Glu Lys Tyr Lys Pro Phe Ser Gln Val Pro Thr Gly Glu 
        515                 520                 525             


Val Phe Tyr Tyr Ser Cys Glu Tyr Asn Phe Val Ser Pro Ser Lys Ser 
    530                 535                 540                 


Phe Trp Thr Arg Ile Thr Cys Thr Glu Glu Gly Trp Ser Pro Thr Pro 
545                 550                 555                 560 


Lys Cys Leu Arg Leu Cys Phe Phe Pro Phe Val Glu Asn Gly His Ser 
                565                 570                 575     


Glu Ser Ser Gly Gln Thr His Leu Glu Gly Asp Thr Val Gln Ile Ile 
            580                 585                 590         


Cys Asn Thr Gly Tyr Arg Leu Gln Asn Asn Glu Asn Asn Ile Ser Cys 
        595                 600                 605             


Val Glu Arg Gly Trp Ser Thr Pro Pro Lys Cys Arg Ser Thr Asp Thr 
    610                 615                 620                 


Ser Cys Val Asn Pro Pro Thr Val Gln Asn Ala His Ile Leu Ser Arg 
625                 630                 635                 640 


Gln Met Ser Lys Tyr Pro Ser Gly Glu Arg Val Arg Tyr Glu Cys Arg 
                645                 650                 655     


Ser Pro Tyr Glu Met Phe Gly Asp Glu Glu Val Met Cys Leu Asn Gly 
            660                 665                 670         


Asn Trp Thr Glu Pro Pro Gln Cys Lys Asp Ser Thr Gly Lys Cys Gly 
        675                 680                 685             


Pro Pro Pro Pro Ile Asp Asn Gly Asp Ile Thr Ser Phe Pro Leu Ser 
    690                 695                 700                 


Val Tyr Ala Pro Ala Ser Ser Val Glu Tyr Gln Cys Gln Asn Leu Tyr 
705                 710                 715                 720 


Gln Leu Glu Gly Asn Lys Arg Ile Thr Cys Arg Asn Gly Gln Trp Ser 
                725                 730                 735     


Glu Pro Pro Lys Cys Leu His Pro Cys Val Ile Ser Arg Glu Ile Met 
            740                 745                 750         


Glu Asn Tyr Asn Ile Ala Leu Arg Trp Thr Ala Lys Gln Lys Leu Tyr 
        755                 760                 765             


Leu Arg Thr Gly Glu Ser Ala Glu Phe Val Cys Lys Arg Gly Tyr Arg 
    770                 775                 780                 


Leu Ser Ser Arg Ser His Thr Leu Arg Thr Thr Cys Trp Asp Gly Lys 
785                 790                 795                 800 


Leu Glu Tyr Pro Thr Cys Ala Lys Arg 
                805                 


<210>  93
<211>  2430
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence encoding VEGF capture protein 2 -furin-P2A-
       CFHR1

<400>  93
atgcgccgcc tgctgacctt catcagcatc ctggccctgg tgggcgccgc cttcgccagc       60

gacaccggcc gccccttcgt ggagatgtac agcgagatcc ccgagatcat ccacatgacc      120

gagggccgcg agctggtgat cccctgccgc gtgaccagcc ccaacatcac cgtgaccctg      180

aagaagttcc ccctggacac cctgatcccc gacggcaagc gcatcatctg ggacagccgc      240

aagggcttca tcatcagcaa cgccacctac aaggagatcg gcctgctgac ctgcgaggcc      300

accgtgaacg gccacctgta caagaccaac tacctgaccc accgccagac caacaccatc      360

atcgacgtgg tgctgagccc cagccacggc atcgagctga gcgtgggcga gaagctggtg      420

ctgaactgca ccgcccgcac cgagctgaac gtgggcatcg acttcaactg ggagtacccc      480

agcagcaagc accagcacaa gaagctggtg aaccgcgacc tgaagaccca gagcggcagc      540

gagatgaaga agttcctgag caccctgacc atcgacggcg tgacccgcag cgaccagggc      600

ctgtacacct gcgccgccag cagcggcctg atgaccaaga agaacagcac cttcgtgcgc      660

gtgcacgaga aggacaagac ccacacctgc cccccctgcc ccgcccccga ggccgccggc      720

ggccccagcg tgttcctgtt cccccccaag cccaaggaca ccctgatgat cagccgcacc      780

cccgaggtga cctgcgtggt ggtggacgtg agccacgagg accccgaggt gaagttcaac      840

tggtacgtgg acggcgtgga ggtgcacaac gccaagacca agccccgcga ggagcagtac      900

aacagcacct accgcgtggt gagcgtgctg accgtgctgg cccaggactg gctgaacggc      960

aaggagtaca agtgcaaggt gagcaacaag gccctgggcg cccccatcga gaagaccatc     1020

agcaaggcca agggccagcc ccgcgagccc caggtgtaca ccctgccccc cagccgcgac     1080

gagctgacca agaaccaggt gagcctgacc tgcctggtga agggcttcta ccccagcgac     1140

atcgccgtgg agtgggagag caacggccag cccgagaaca actacaagac cacccccccc     1200

gtgctggaca gcgacggcag cttcttcctg tacagcaagc tgaccgtgga caagagccgc     1260

tggcagcagg gcaacgtgtt cagctgcagc gtgatgcacg aggccctgca caacgcctac     1320

acccagaaga gcctgagcct gagccccggc cgccgcagca agcgcagcgg cagcggcgcc     1380

accaacttca gcctgctgaa gcaggccggc gacgtggagg agaaccccgg ccccatgcgc     1440

cgcttcctga ccgtgatcag cttcctgctg tacttcggct gcgccttcgc cgaagcaaca     1500

ttttgtgatt ttccaaaaat aaaccatgga attctatatg atgaagaaaa atataagcca     1560

ttttcccagg ttcctacagg ggaagttttc tattactcct gtgaatataa ttttgtgtct     1620

ccttcaaaat cattttggac tcgcataaca tgcacagaag aaggatggtc accaacacca     1680

aagtgtctca gactgtgttt ctttcctttt gtggaaaatg gtcattctga atcttcagga     1740

caaacacatc tggaaggtga tactgtgcaa attatttgca acacaggata cagacttcaa     1800

aacaatgaga acaacatttc atgtgtagaa cggggctggt ccacccctcc caaatgcagg     1860

tccactgaca cttcctgtgt gaatccgccc acagtacaaa atgctcatat actgtcgaga     1920

cagatgagta aatatccatc tggtgagaga gtacgttatg aatgtaggag cccttatgaa     1980

atgtttgggg atgaagaagt gatgtgttta aatggaaact ggacagaacc acctcaatgc     2040

aaagattcta cgggaaaatg tgggccccct ccacctattg acaatgggga cattacttca     2100

ttcccgttgt cagtatatgc tccagcttca tcagttgagt accaatgcca gaacttgtat     2160

caacttgagg gtaacaagcg aataacatgt agaaatggac aatggtcaga accaccaaaa     2220

tgcttacatc cgtgtgtaat atcccgagaa attatggaaa attataacat agcattaagg     2280

tggacagcca aacagaagct ttatttgaga acaggtgaat cagctgaatt tgtgtgtaaa     2340

cggggatatc gtctttcatc acgttctcac acattgcgaa caacatgttg ggatgggaaa     2400

ctggagtatc caacttgtgc aaaaagataa                                      2430


<210>  94
<211>  809
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CFHR1-furin-P2A- VEGF capture protein 2

<400>  94

Met Arg Arg Phe Leu Thr Val Ile Ser Phe Leu Leu Tyr Phe Gly Cys 
1               5                   10                  15      


Ala Phe Ala Glu Ala Thr Phe Cys Asp Phe Pro Lys Ile Asn His Gly 
            20                  25                  30          


Ile Leu Tyr Asp Glu Glu Lys Tyr Lys Pro Phe Ser Gln Val Pro Thr 
        35                  40                  45              


Gly Glu Val Phe Tyr Tyr Ser Cys Glu Tyr Asn Phe Val Ser Pro Ser 
    50                  55                  60                  


Lys Ser Phe Trp Thr Arg Ile Thr Cys Thr Glu Glu Gly Trp Ser Pro 
65                  70                  75                  80  


Thr Pro Lys Cys Leu Arg Leu Cys Phe Phe Pro Phe Val Glu Asn Gly 
                85                  90                  95      


His Ser Glu Ser Ser Gly Gln Thr His Leu Glu Gly Asp Thr Val Gln 
            100                 105                 110         


Ile Ile Cys Asn Thr Gly Tyr Arg Leu Gln Asn Asn Glu Asn Asn Ile 
        115                 120                 125             


Ser Cys Val Glu Arg Gly Trp Ser Thr Pro Pro Lys Cys Arg Ser Thr 
    130                 135                 140                 


Asp Thr Ser Cys Val Asn Pro Pro Thr Val Gln Asn Ala His Ile Leu 
145                 150                 155                 160 


Ser Arg Gln Met Ser Lys Tyr Pro Ser Gly Glu Arg Val Arg Tyr Glu 
                165                 170                 175     


Cys Arg Ser Pro Tyr Glu Met Phe Gly Asp Glu Glu Val Met Cys Leu 
            180                 185                 190         


Asn Gly Asn Trp Thr Glu Pro Pro Gln Cys Lys Asp Ser Thr Gly Lys 
        195                 200                 205             


Cys Gly Pro Pro Pro Pro Ile Asp Asn Gly Asp Ile Thr Ser Phe Pro 
    210                 215                 220                 


Leu Ser Val Tyr Ala Pro Ala Ser Ser Val Glu Tyr Gln Cys Gln Asn 
225                 230                 235                 240 


Leu Tyr Gln Leu Glu Gly Asn Lys Arg Ile Thr Cys Arg Asn Gly Gln 
                245                 250                 255     


Trp Ser Glu Pro Pro Lys Cys Leu His Pro Cys Val Ile Ser Arg Glu 
            260                 265                 270         


Ile Met Glu Asn Tyr Asn Ile Ala Leu Arg Trp Thr Ala Lys Gln Lys 
        275                 280                 285             


Leu Tyr Leu Arg Thr Gly Glu Ser Ala Glu Phe Val Cys Lys Arg Gly 
    290                 295                 300                 


Tyr Arg Leu Ser Ser Arg Ser His Thr Leu Arg Thr Thr Cys Trp Asp 
305                 310                 315                 320 


Gly Lys Leu Glu Tyr Pro Thr Cys Ala Lys Arg Arg Arg Ser Lys Arg 
                325                 330                 335     


Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp 
            340                 345                 350         


Val Glu Glu Asn Pro Gly Pro Met Arg Arg Leu Leu Thr Phe Ile Ser 
        355                 360                 365             


Ile Leu Ala Leu Val Gly Ala Ala Phe Ala Ser Asp Thr Gly Arg Pro 
    370                 375                 380                 


Phe Val Glu Met Tyr Ser Glu Ile Pro Glu Ile Ile His Met Thr Glu 
385                 390                 395                 400 


Gly Arg Glu Leu Val Ile Pro Cys Arg Val Thr Ser Pro Asn Ile Thr 
                405                 410                 415     


Val Thr Leu Lys Lys Phe Pro Leu Asp Thr Leu Ile Pro Asp Gly Lys 
            420                 425                 430         


Arg Ile Ile Trp Asp Ser Arg Lys Gly Phe Ile Ile Ser Asn Ala Thr 
        435                 440                 445             


Tyr Lys Glu Ile Gly Leu Leu Thr Cys Glu Ala Thr Val Asn Gly His 
    450                 455                 460                 


Leu Tyr Lys Thr Asn Tyr Leu Thr His Arg Gln Thr Asn Thr Ile Ile 
465                 470                 475                 480 


Asp Val Val Leu Ser Pro Ser His Gly Ile Glu Leu Ser Val Gly Glu 
                485                 490                 495     


Lys Leu Val Leu Asn Cys Thr Ala Arg Thr Glu Leu Asn Val Gly Ile 
            500                 505                 510         


Asp Phe Asn Trp Glu Tyr Pro Ser Ser Lys His Gln His Lys Lys Leu 
        515                 520                 525             


Val Asn Arg Asp Leu Lys Thr Gln Ser Gly Ser Glu Met Lys Lys Phe 
    530                 535                 540                 


Leu Ser Thr Leu Thr Ile Asp Gly Val Thr Arg Ser Asp Gln Gly Leu 
545                 550                 555                 560 


Tyr Thr Cys Ala Ala Ser Ser Gly Leu Met Thr Lys Lys Asn Ser Thr 
                565                 570                 575     


Phe Val Arg Val His Glu Lys Asp Lys Thr His Thr Cys Pro Pro Cys 
            580                 585                 590         


Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        595                 600                 605             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    610                 615                 620                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
625                 630                 635                 640 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                645                 650                 655     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            660                 665                 670         


Ala Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        675                 680                 685             


Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    690                 695                 700                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
705                 710                 715                 720 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                725                 730                 735     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            740                 745                 750         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        755                 760                 765             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    770                 775                 780                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Ala Tyr Thr 
785                 790                 795                 800 


Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                805                 


<210>  95
<211>  2430
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence encoding CFHR1-furin-P2A- VEGF capture 
       protein 2

<400>  95
atgcgccgct tcctgaccgt gatcagcttc ctgctgtact tcggctgcgc cttcgccgaa       60

gcaacatttt gtgattttcc aaaaataaac catggaattc tatatgatga agaaaaatat      120

aagccatttt cccaggttcc tacaggggaa gttttctatt actcctgtga atataatttt      180

gtgtctcctt caaaatcatt ttggactcgc ataacatgca cagaagaagg atggtcacca      240

acaccaaagt gtctcagact gtgtttcttt ccttttgtgg aaaatggtca ttctgaatct      300

tcaggacaaa cacatctgga aggtgatact gtgcaaatta tttgcaacac aggatacaga      360

cttcaaaaca atgagaacaa catttcatgt gtagaacggg gctggtccac ccctcccaaa      420

tgcaggtcca ctgacacttc ctgtgtgaat ccgcccacag tacaaaatgc tcatatactg      480

tcgagacaga tgagtaaata tccatctggt gagagagtac gttatgaatg taggagccct      540

tatgaaatgt ttggggatga agaagtgatg tgtttaaatg gaaactggac agaaccacct      600

caatgcaaag attctacggg aaaatgtggg ccccctccac ctattgacaa tggggacatt      660

acttcattcc cgttgtcagt atatgctcca gcttcatcag ttgagtacca atgccagaac      720

ttgtatcaac ttgagggtaa caagcgaata acatgtagaa atggacaatg gtcagaacca      780

ccaaaatgct tacatccgtg tgtaatatcc cgagaaatta tggaaaatta taacatagca      840

ttaaggtgga cagccaaaca gaagctttat ttgagaacag gtgaatcagc tgaatttgtg      900

tgtaaacggg gatatcgtct ttcatcacgt tctcacacat tgcgaacaac atgttgggat      960

gggaaactgg agtatccaac ttgtgcaaaa agacgccgca gcaagcgcag cggcagcggc     1020

gccaccaact tcagcctgct gaagcaggcc ggcgacgtgg aggagaaccc cggccccatg     1080

cgccgcctgc tgaccttcat cagcatcctg gccctggtgg gcgccgcctt cgccagcgac     1140

accggccgcc ccttcgtgga gatgtacagc gagatccccg agatcatcca catgaccgag     1200

ggccgcgagc tggtgatccc ctgccgcgtg accagcccca acatcaccgt gaccctgaag     1260

aagttccccc tggacaccct gatccccgac ggcaagcgca tcatctggga cagccgcaag     1320

ggcttcatca tcagcaacgc cacctacaag gagatcggcc tgctgacctg cgaggccacc     1380

gtgaacggcc acctgtacaa gaccaactac ctgacccacc gccagaccaa caccatcatc     1440

gacgtggtgc tgagccccag ccacggcatc gagctgagcg tgggcgagaa gctggtgctg     1500

aactgcaccg cccgcaccga gctgaacgtg ggcatcgact tcaactggga gtaccccagc     1560

agcaagcacc agcacaagaa gctggtgaac cgcgacctga agacccagag cggcagcgag     1620

atgaagaagt tcctgagcac cctgaccatc gacggcgtga cccgcagcga ccagggcctg     1680

tacacctgcg ccgccagcag cggcctgatg accaagaaga acagcacctt cgtgcgcgtg     1740

cacgagaagg acaagaccca cacctgcccc ccctgccccg cccccgaggc cgccggcggc     1800

cccagcgtgt tcctgttccc ccccaagccc aaggacaccc tgatgatcag ccgcaccccc     1860

gaggtgacct gcgtggtggt ggacgtgagc cacgaggacc ccgaggtgaa gttcaactgg     1920

tacgtggacg gcgtggaggt gcacaacgcc aagaccaagc cccgcgagga gcagtacaac     1980

agcacctacc gcgtggtgag cgtgctgacc gtgctggccc aggactggct gaacggcaag     2040

gagtacaagt gcaaggtgag caacaaggcc ctgggcgccc ccatcgagaa gaccatcagc     2100

aaggccaagg gccagccccg cgagccccag gtgtacaccc tgccccccag ccgcgacgag     2160

ctgaccaaga accaggtgag cctgacctgc ctggtgaagg gcttctaccc cagcgacatc     2220

gccgtggagt gggagagcaa cggccagccc gagaacaact acaagaccac cccccccgtg     2280

ctggacagcg acggcagctt cttcctgtac agcaagctga ccgtggacaa gagccgctgg     2340

cagcagggca acgtgttcag ctgcagcgtg atgcacgagg ccctgcacaa cgcctacacc     2400

cagaagagcc tgagcctgag ccccggctaa                                      2430


<210>  96
<211>  4246
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant vector (e.g. known as "IKC153P")

<400>  96
cgcgctcgct cgctcactga ggccgcccgg gcaaagcccg ggcggcctca gtgagcgagc       60

gagcgcgcag agagggagtg gccaactcca tcactagggg ttccttgtag ttaatgatta      120

acccgccatg ctacttatct acgtagccat gctctagaca tggctcgaca gatcgagctc      180

caccgggtac cctagttatt aatagtaatc aattacgggg tcattagttc atagcccata      240

tatggagttc cgcgttacat aacttacggt aaatggcccg cctggctgac cgcccaacga      300

cccccgccca ttgacgtcaa taatgacgta tgttcccata gtaacgccaa tagggacttt      360

ccattgacgt caatgggtgg actatttacg gtaaactgcc cacttggcag tacatcaagt      420

gtatcatatg ccaagtacgc cccctattga cgtcaatgac ggtaaatggc ccgcctggca      480

ttatgcccag tacatgacct tatgggactt tcctacttgg cagtacatct acgtattagt      540

catcgctatt accatggtcg aggtgagccc cacgttctgc ttcactctcc ccatctcccc      600

cccctcccca cccccaattt tgtatttatt tattttttaa ttattttgtg cagcgatggg      660

ggcggggggg gggggggggc gcgcgccagg cggggcgggg cggggcgagg ggcggggcgg      720

ggcgaggcgg agaggtgcgg cggcagccaa tcagagcggc gcgctccgaa agtttccttt      780

tatggcgagg cggcggcggc ggcggcccta taaaaagcga agcgcgcggc gggcgggagt      840

cgctgcgacg ctgccttcgc cccgtgcccc gctccgccgc cgcctcgcgc cgcccgcccc      900

ggctctgact gaccgcgtta ctcccacagg tgagcgggcg ggacggccct tctcctccgg      960

gctgtaatta gcgcttggtt taatgacggc ttgtttcttt tctgtggctg cgtgaaagcc     1020

ttgaggggct ccgggaggct agagcctctg ctaaccatgt tcatgccttc ttctttttcc     1080

tacagctcct gggcaacgtg ctggttattg tgctgtctca tcattttggc aaagaattcc     1140

ggactcgacc cgctagcgcc accatgcgcc gcctgctgac cttcatcagc atcctggccc     1200

tggtgggcgc cgccttcgcc agcgacaccg gccgcccctt cgtggagatg tacagcgaga     1260

tccccgagat catccacatg accgagggcc gcgagctggt gatcccctgc cgcgtgacca     1320

gccccaacat caccgtgacc ctgaagaagt tccccctgga caccctgatc cccgacggca     1380

agcgcatcat ctgggacagc cgcaagggct tcatcatcag caacgccacc tacaaggaga     1440

tcggcctgct gacctgcgag gccaccgtga acggccacct gtacaagacc aactacctga     1500

cccaccgcca gaccaacacc atcatcgacg tggtgctgag ccccagccac ggcatcgagc     1560

tgagcgtggg cgagaagctg gtgctgaact gcaccgcccg caccgagctg aacgtgggca     1620

tcgacttcaa ctgggagtac cccagcagca agcaccagca caagaagctg gtgaaccgcg     1680

acctgaagac ccagagcggc agcgagatga agaagttcct gagcaccctg accatcgacg     1740

gcgtgacccg cagcgaccag ggcctgtaca cctgcgccgc cagcagcggc ctgatgacca     1800

agaagaacag caccttcgtg cgcgtgcacg agaaggacaa gacccacacc tgccccccct     1860

gccccgcccc cgaggccgcc ggcggcccca gcgtgttcct gttccccccc aagcccaagg     1920

acaccctgat gatcagccgc acccccgagg tgacctgcgt ggtggtggac gtgagccacg     1980

aggaccccga ggtgaagttc aactggtacg tggacggcgt ggaggtgcac aacgccaaga     2040

ccaagccccg cgaggagcag tacaacagca cctaccgcgt ggtgagcgtg ctgaccgtgc     2100

tggcccagga ctggctgaac ggcaaggagt acaagtgcaa ggtgagcaac aaggccctgg     2160

gcgcccccat cgagaagacc atcagcaagg ccaagggcca gccccgcgag ccccaggtgt     2220

acaccctgcc ccccagccgc gacgagctga ccaagaacca ggtgagcctg acctgcctgg     2280

tgaagggctt ctaccccagc gacatcgccg tggagtggga gagcaacggc cagcccgaga     2340

acaactacaa gaccaccccc cccgtgctgg acagcgacgg cagcttcttc ctgtacagca     2400

agctgaccgt ggacaagagc cgctggcagc agggcaacgt gttcagctgc agcgtgatgc     2460

acgaggccct gcacaacgcc tacacccaga agagcctgag cctgagcccc ggccgccgca     2520

gcaagcgcag cggcagcggc gccaccaact tcagcctgct gaagcaggcc ggcgacgtgg     2580

aggagaaccc cggccccatg cgccgcttcc tgaccgtgat cagcttcctg ctgtacttcg     2640

gctgcgcctt cgccgacatc cagatgaccc agagccccag cagcctgagc gccagcgtgg     2700

gcgaccgcgt gaccatcacc tgccgcgcca gccagggcat cagcagctgg ctggcctggt     2760

accagcagaa gcccgagaag gcccccaaga gcctgatcta cgccgccagc agcctccaga     2820

gcggcgtgcc cagccgcttc agcggcagcg gcagcggcac cgacttcacc ctgaccatca     2880

gcagcctcca gcccgaggac ttcgccacct actactgcca gcagtacaac agctaccccc     2940

ccaccttcgg ccagggcacc aagctggaga tcaagcgcgg cggcggcggc ggcagcggcg     3000

gcggcggcag cggcggcggc ggcagcggcg gcggcggcag cgagggccag ctggtgcaga     3060

gcggcggcgg cctggtgcac cccggcggca gcctgcgcct gagctgcgcc ggcagcggct     3120

tcaccttcag cagctacggc atgcactggg tgcgccaggc ccccggcaag ggcctggagt     3180

gggtgagcgg catcggcacc ggcggcggca cctacagcac cgacagcgtg aagggccgct     3240

tcaccatcag ccgcgacaac gccaagaaca gcctgtacct ccagatgaac agcctgcgcg     3300

ccgaggacat ggccgtgtac tactgcgccc gcggcgacta ctacggcagc ggcagcttct     3360

tcgactgctg gggccagggc accctggtga ccgtgagcag ctaagtatac tactagtacg     3420

cggccgcacc ggtgtacaat caacctctgg attacaaaat ttgtgaaaga ttgactggta     3480

ttcttaacta tgttgctcct tttacgctat gtggatacgc tgctttaatg cctttgtatc     3540

atgctattgc ttcccgtatg gctttcattt tctcctcctt gtataaatcc tggttagttc     3600

ttgccacggc ggaactcatc gccgcctgcc ttgcccgctg ctggacaggg gctcggctgt     3660

tgggcactga caattccgtg gtgtgaattc gagctaggta cagcttatcg ataccgtcga     3720

cagcagacat gataagatac attgatgagt ttggacaaac cacaactaga atgcagtgaa     3780

aaaaatgctt tatttgtgaa atttgtgatg ctattgcttt atttgtaacc attataagct     3840

gcaataaaca agttaacaac aacaattgca ttcattttat gtttcaggtt cagggggagg     3900

tgtgggaggt tttttaaagc aagtaaaacc tctacaaatg tggtatgctc gagggcatgc     3960

aacaacaaca attgcattca ttttatgttt caggttcagg gggagatgtg ggaggttttt     4020

taaagcaagt aaaacctcta caaatgtggt aaaatccgat aaggactaga gcatggctac     4080

gtagataagt agcatggcgg gttaatcatt aactacaagg aacccctagt gatggagttg     4140

gccactccct ctctgcgcgc tcgctcgctc actgaggccg ggcgaccaaa ggtcgcccga     4200

cgcccgggct ttgcccgggc ggcctcagtg agcgagcgag cgcgca                    4246


<210>  97
<211>  426
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CFHL1

<400>  97

Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile Leu Thr 
1               5                   10                  15      


Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala Ile Tyr 
            20                  25                  30          


Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met Val Cys 
        35                  40                  45              


Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys Gln Lys 
    50                  55                  60                  


Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe Thr Leu 
65                  70                  75                  80  


Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr Thr Cys 
                85                  90                  95      


Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu Cys Asp 
            100                 105                 110         


Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val Lys Cys 
        115                 120                 125             


Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser Ala Met 
    130                 135                 140                 


Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe Val Cys 
145                 150                 155                 160 


Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys Ser Asp 
                165                 170                 175     


Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile Ser Cys 
            180                 185                 190         


Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys Ile Ile 
        195                 200                 205             


Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly Tyr Glu 
    210                 215                 220                 


Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp Arg Pro 
225                 230                 235                 240 


Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile Pro Asn 
                245                 250                 255     


Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp Glu Ile 
            260                 265                 270         


Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly Asn Thr 
        275                 280                 285             


Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys Thr Leu 
    290                 295                 300                 


Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr His Glu 
305                 310                 315                 320 


Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr Tyr Ser 
                325                 330                 335     


Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr Trp Asp 
            340                 345                 350         


His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro Cys Leu 
        355                 360                 365             


Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln Asn Tyr 
    370                 375                 380                 


Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys His Pro 
385                 390                 395                 400 


Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met Glu Asn 
                405                 410                 415     


Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg 
            420                 425     


<210>  98
<211>  1278
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence encoding CFHL1

<400>  98
gaggactgca acgagctgcc cccccgccgc aacaccgaga tcctgaccgg cagctggagc       60

gaccagacct accccgaggg cacccaggcc atctacaagt gccgccccgg ctaccgcagc      120

ctgggcaacg tgatcatggt gtgccgcaag ggcgagtggg tggccctgaa ccccctgcgc      180

aagtgccaga agcgcccctg cggccacccc ggcgacaccc ccttcggcac cttcaccctg      240

accggcggca acgtgttcga gtacggcgtg aaggccgtgt acacctgcaa cgagggctac      300

cagctgctgg gcgagatcaa ctaccgcgag tgcgacaccg acggctggac caacgacatc      360

cccatctgcg aggtggtgaa gtgcctgccc gtgaccgccc ccgagaacgg caagatcgtg      420

agcagcgcca tggagcccga ccgcgagtac cacttcggcc aggccgtgcg cttcgtgtgc      480

aacagcggct acaagatcga gggcgacgag gagatgcact gcagcgacga cggcttctgg      540

agcaaggaga agcccaagtg cgtggagatc agctgcaaga gccccgacgt gatcaacggc      600

agccccatca gccagaagat catctacaag gagaacgagc gcttccagta caagtgcaac      660

atgggctacg agtacagcga gcgcggcgac gccgtgtgca ccgagagcgg ctggcgcccc      720

ctgcccagct gcgaggagaa gagctgcgac aacccctaca tccccaacgg cgactacagc      780

cccctgcgca tcaagcaccg caccggcgac gagatcacct accagtgccg caacggcttc      840

taccccgcca cccggggcaa caccgccaag tgcaccagca ccggctggat ccccgccccc      900

cgctgcaccc tgaagccctg cgactacccc gacatcaagc acggcggcct gtaccacgag      960

aacatgcgcc gcccctactt ccccgtggcc gtgggcaagt actacagcta ctactgcgac     1020

gagcacttcg agacccccag cggcagctac tgggaccaca tccactgcac ccaggacggc     1080

tggagccccg ccgtgccctg cctgcgcaag tgctacttcc cctacctgga gaacggctac     1140

aaccagaact acggccgcaa gttcgtgcag ggcaagagca tcgacgtggc ctgccacccc     1200

ggctacgccc tgcccaaggc ccagaccacc gtgacctgca tggagaacgg ctggagcccc     1260

accccccgct gcatccgc                                                   1278


<210>  99
<211>  225
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  bovine growth hormone poly-A nucleotide sequence

<400>  99
ctgtgccttc tagttgccag ccatctgttg tttgcccctc ccccgtgcct tccttgaccc       60

tggaaggtgc cactcccact gtcctttcct aataaaatga ggaaattgca tcgcattgtc      120

tgagtaggtg tcattctatt ctggggggtg gggtggggca ggacagcaag ggggaggatt      180

gggaagacaa tagcaggcat gctggggatg cggtgggctc tatgg                      225


<210>  100
<211>  922
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VEGF capture protein 2-furin-P2A-CFHL1

<400>  100

Met Arg Arg Leu Leu Thr Phe Ile Ser Ile Leu Ala Leu Val Gly Ala 
1               5                   10                  15      


Ala Phe Ala Ser Asp Thr Gly Arg Pro Phe Val Glu Met Tyr Ser Glu 
            20                  25                  30          


Ile Pro Glu Ile Ile His Met Thr Glu Gly Arg Glu Leu Val Ile Pro 
        35                  40                  45              


Cys Arg Val Thr Ser Pro Asn Ile Thr Val Thr Leu Lys Lys Phe Pro 
    50                  55                  60                  


Leu Asp Thr Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp Asp Ser Arg 
65                  70                  75                  80  


Lys Gly Phe Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile Gly Leu Leu 
                85                  90                  95      


Thr Cys Glu Ala Thr Val Asn Gly His Leu Tyr Lys Thr Asn Tyr Leu 
            100                 105                 110         


Thr His Arg Gln Thr Asn Thr Ile Ile Asp Val Val Leu Ser Pro Ser 
        115                 120                 125             


His Gly Ile Glu Leu Ser Val Gly Glu Lys Leu Val Leu Asn Cys Thr 
    130                 135                 140                 


Ala Arg Thr Glu Leu Asn Val Gly Ile Asp Phe Asn Trp Glu Tyr Pro 
145                 150                 155                 160 


Ser Ser Lys His Gln His Lys Lys Leu Val Asn Arg Asp Leu Lys Thr 
                165                 170                 175     


Gln Ser Gly Ser Glu Met Lys Lys Phe Leu Ser Thr Leu Thr Ile Asp 
            180                 185                 190         


Gly Val Thr Arg Ser Asp Gln Gly Leu Tyr Thr Cys Ala Ala Ser Ser 
        195                 200                 205             


Gly Leu Met Thr Lys Lys Asn Ser Thr Phe Val Arg Val His Glu Lys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu Ala Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn Ala Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Arg Arg Ser Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser 
    450                 455                 460                 


Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Arg 
465                 470                 475                 480 


Arg Leu Leu Thr Phe Ile Ser Ile Leu Ala Leu Val Gly Ala Phe Ala 
                485                 490                 495     


Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile Leu Thr 
            500                 505                 510         


Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala Ile Tyr 
        515                 520                 525             


Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met Val Cys 
    530                 535                 540                 


Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys Gln Lys 
545                 550                 555                 560 


Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe Thr Leu 
                565                 570                 575     


Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr Thr Cys 
            580                 585                 590         


Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu Cys Asp 
        595                 600                 605             


Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val Lys Cys 
    610                 615                 620                 


Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser Ala Met 
625                 630                 635                 640 


Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe Val Cys 
                645                 650                 655     


Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys Ser Asp 
            660                 665                 670         


Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile Ser Cys 
        675                 680                 685             


Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys Ile Ile 
    690                 695                 700                 


Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly Tyr Glu 
705                 710                 715                 720 


Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp Arg Pro 
                725                 730                 735     


Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile Pro Asn 
            740                 745                 750         


Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp Glu Ile 
        755                 760                 765             


Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly Asn Thr 
    770                 775                 780                 


Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys Thr Leu 
785                 790                 795                 800 


Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr His Glu 
                805                 810                 815     


Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr Tyr Ser 
            820                 825                 830         


Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr Trp Asp 
        835                 840                 845             


His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro Cys Leu 
    850                 855                 860                 


Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln Asn Tyr 
865                 870                 875                 880 


Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys His Pro 
                885                 890                 895     


Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met Glu Asn 
            900                 905                 910         


Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg 
        915                 920         


<210>  101
<211>  2769
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence encoding VEGF capture protein 
       2-furin-P2A-CFHL1

<400>  101
atgcgccgcc tgctgacctt catcagcatc ctggccctgg tgggcgccgc cttcgccagc       60

gacaccggcc gccccttcgt ggagatgtac agcgagatcc ccgagatcat ccacatgacc      120

gagggccgcg agctggtgat cccctgccgc gtgaccagcc ccaacatcac cgtgaccctg      180

aagaagttcc ccctggacac cctgatcccc gacggcaagc gcatcatctg ggacagccgc      240

aagggcttca tcatcagcaa cgccacctac aaggagatcg gcctgctgac ctgcgaggcc      300

accgtgaacg gccacctgta caagaccaac tacctgaccc accgccagac caacaccatc      360

atcgacgtgg tgctgagccc cagccacggc atcgagctga gcgtgggcga gaagctggtg      420

ctgaactgca ccgcccgcac cgagctgaac gtgggcatcg acttcaactg ggagtacccc      480

agcagcaagc accagcacaa gaagctggtg aaccgcgacc tgaagaccca gagcggcagc      540

gagatgaaga agttcctgag caccctgacc atcgacggcg tgacccgcag cgaccagggc      600

ctgtacacct gcgccgccag cagcggcctg atgaccaaga agaacagcac cttcgtgcgc      660

gtgcacgaga aggacaagac ccacacctgc cccccctgcc ccgcccccga ggccgccggc      720

ggccccagcg tgttcctgtt cccccccaag cccaaggaca ccctgatgat cagccgcacc      780

cccgaggtga cctgcgtggt ggtggacgtg agccacgagg accccgaggt gaagttcaac      840

tggtacgtgg acggcgtgga ggtgcacaac gccaagacca agccccgcga ggagcagtac      900

aacagcacct accgcgtggt gagcgtgctg accgtgctgg cccaggactg gctgaacggc      960

aaggagtaca agtgcaaggt gagcaacaag gccctgggcg cccccatcga gaagaccatc     1020

agcaaggcca agggccagcc ccgcgagccc caggtgtaca ccctgccccc cagccgcgac     1080

gagctgacca agaaccaggt gagcctgacc tgcctggtga agggcttcta ccccagcgac     1140

atcgccgtgg agtgggagag caacggccag cccgagaaca actacaagac cacccccccc     1200

gtgctggaca gcgacggcag cttcttcctg tacagcaagc tgaccgtgga caagagccgc     1260

tggcagcagg gcaacgtgtt cagctgcagc gtgatgcacg aggccctgca caacgcctac     1320

acccagaaga gcctgagcct gagccccggc cgccgcagca agcgcagcgg cagcggcgcc     1380

accaacttca gcctgctgaa gcaggccggc gacgtggagg agaaccccgg ccccatgcgc     1440

cgcctgctga ccttcatcag catcctggcc ctggtgggcg ccttcgccga ggactgcaac     1500

gagctgcccc cccgccgcaa caccgagatc ctgaccggca gctggagcga ccagacctac     1560

cccgagggca cccaggccat ctacaagtgc cgccccggct accgcagcct gggcaacgtg     1620

atcatggtgt gccgcaaggg cgagtgggtg gccctgaacc ccctgcgcaa gtgccagaag     1680

cgcccctgcg gccaccccgg cgacaccccc ttcggcacct tcaccctgac cggcggcaac     1740

gtgttcgagt acggcgtgaa ggccgtgtac acctgcaacg agggctacca gctgctgggc     1800

gagatcaact accgcgagtg cgacaccgac ggctggacca acgacatccc catctgcgag     1860

gtggtgaagt gcctgcccgt gaccgccccc gagaacggca agatcgtgag cagcgccatg     1920

gagcccgacc gcgagtacca cttcggccag gccgtgcgct tcgtgtgcaa cagcggctac     1980

aagatcgagg gcgacgagga gatgcactgt agcgacgacg gcttctggag caaggagaag     2040

cccaagtgcg tggagatcag ctgcaagagc cccgacgtga tcaacggcag ccccatcagc     2100

cagaagatca tctacaagga gaacgagcgc ttccagtaca agtgcaacat gggctacgag     2160

tacagcgagc gcggcgacgc cgtgtgcacc gagagcggct ggcgccccct gcccagctgc     2220

gaggagaaga gctgcgacaa cccctacatc cccaacggcg actacagccc cctgcgcatc     2280

aagcaccgca ccggcgacga gatcacctac cagtgccgca acggcttcta ccccgccacc     2340

cgcggcaaca ccgccaagtg caccagcacc ggctggatcc ccgccccccg ctgcaccctg     2400

aagccctgcg actaccccga catcaagcac ggcggcctgt accacgagaa catgcgccgc     2460

ccctacttcc ccgtggccgt gggcaagtac tacagctact actgcgacga gcacttcgag     2520

acccccagcg gcagctactg ggaccacatc cactgcaccc aggacggctg gagccccgcc     2580

gtgccctgcc tgcgcaagtg ctacttcccc tacctggaga acggctacaa ccagaactac     2640

ggccgcaagt tcgtgcaggg caagagcatc gacgtggcct gccaccccgg ctacgccctg     2700

cccaaggccc agaccaccgt gacctgcatg gagaacggct ggagccccac cccccgctgc     2760

atccgctag                                                             2769


<210>  102
<211>  922
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CFHL1-furin-P2A-VEGF capture protein 2

<400>  102

Met Arg Arg Leu Leu Thr Phe Ile Ser Ile Leu Ala Leu Val Gly Ala 
1               5                   10                  15      


Phe Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          


Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              


Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  


Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  


Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      


Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         


Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             


Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 


Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 


Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     


Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         


Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             


Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 


Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 


Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     


Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
            260                 265                 270         


Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
        275                 280                 285             


Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
    290                 295                 300                 


Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
305                 310                 315                 320 


Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr 
                325                 330                 335     


His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 
            340                 345                 350         


Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 
        355                 360                 365             


Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 
    370                 375                 380                 


Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln 
385                 390                 395                 400 


Asn Tyr Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 
                405                 410                 415     


His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 
            420                 425                 430         


Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Arg Arg Ser Lys 
        435                 440                 445             


Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly 
    450                 455                 460                 


Asp Val Glu Glu Asn Pro Gly Pro Met Arg Arg Leu Leu Thr Phe Ile 
465                 470                 475                 480 


Ser Ile Leu Ala Leu Val Gly Ala Ala Phe Ala Ser Asp Thr Gly Arg 
                485                 490                 495     


Pro Phe Val Glu Met Tyr Ser Glu Ile Pro Glu Ile Ile His Met Thr 
            500                 505                 510         


Glu Gly Arg Glu Leu Val Ile Pro Cys Arg Val Thr Ser Pro Asn Ile 
        515                 520                 525             


Thr Val Thr Leu Lys Lys Phe Pro Leu Asp Thr Leu Ile Pro Asp Gly 
    530                 535                 540                 


Lys Arg Ile Ile Trp Asp Ser Arg Lys Gly Phe Ile Ile Ser Asn Ala 
545                 550                 555                 560 


Thr Tyr Lys Glu Ile Gly Leu Leu Thr Cys Glu Ala Thr Val Asn Gly 
                565                 570                 575     


His Leu Tyr Lys Thr Asn Tyr Leu Thr His Arg Gln Thr Asn Thr Ile 
            580                 585                 590         


Ile Asp Val Val Leu Ser Pro Ser His Gly Ile Glu Leu Ser Val Gly 
        595                 600                 605             


Glu Lys Leu Val Leu Asn Cys Thr Ala Arg Thr Glu Leu Asn Val Gly 
    610                 615                 620                 


Ile Asp Phe Asn Trp Glu Tyr Pro Ser Ser Lys His Gln His Lys Lys 
625                 630                 635                 640 


Leu Val Asn Arg Asp Leu Lys Thr Gln Ser Gly Ser Glu Met Lys Lys 
                645                 650                 655     


Phe Leu Ser Thr Leu Thr Ile Asp Gly Val Thr Arg Ser Asp Gln Gly 
            660                 665                 670         


Leu Tyr Thr Cys Ala Ala Ser Ser Gly Leu Met Thr Lys Lys Asn Ser 
        675                 680                 685             


Thr Phe Val Arg Val His Glu Lys Asp Lys Thr His Thr Cys Pro Pro 
    690                 695                 700                 


Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro 
705                 710                 715                 720 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                725                 730                 735     


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
            740                 745                 750         


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        755                 760                 765             


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    770                 775                 780                 


Leu Ala Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
785                 790                 795                 800 


Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                805                 810                 815     


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
            820                 825                 830         


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        835                 840                 845             


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    850                 855                 860                 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
865                 870                 875                 880 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
                885                 890                 895     


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Ala Tyr 
            900                 905                 910         


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        915                 920         


<210>  103
<211>  2766
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence encoding CFHL1-furin-P2A-VEGF capture 
       protein 2

<400>  103
atgcgccgcc tgctgacctt catcagcatc ctggccctgg tgggcgcctt cgccgaggac       60

tgcaacgagc tgcccccccg ccgcaacacc gagatcctga ccggcagctg gagcgaccag      120

acctaccccg agggcaccca ggccatctac aagtgccgcc ccggctaccg cagcctgggc      180

aacgtgatca tggtgtgccg caagggcgag tgggtggccc tgaaccccct gcgcaagtgc      240

cagaagcgcc cctgcggcca ccccggcgac acccccttcg gcaccttcac cctgaccggc      300

ggcaacgtgt tcgagtacgg cgtgaaggcc gtgtacacct gcaacgaggg ctaccagctg      360

ctgggcgaga tcaactaccg cgagtgcgac accgacggct ggaccaacga catccccatc      420

tgcgaggtgg tgaagtgcct gcccgtgacc gcccccgaga acggcaagat cgtgagcagc      480

gccatggagc ccgaccgcga gtaccacttc ggccaggccg tgcgcttcgt gtgcaacagc      540

ggctacaaga tcgagggcga cgaggagatg cactgtagcg acgacggctt ctggagcaag      600

gagaagccca agtgcgtgga gatcagctgc aagagccccg acgtgatcaa cggcagcccc      660

atcagccaga agatcatcta caaggagaac gagcgcttcc agtacaagtg caacatgggc      720

tacgagtaca gcgagcgcgg cgacgccgtg tgcaccgaga gcggctggcg ccccctgccc      780

agctgcgagg agaagagctg cgacaacccc tacatcccca acggcgacta cagccccctg      840

cgcatcaagc accgcaccgg cgacgagatc acctaccagt gccgcaacgg cttctacccc      900

gccacccgcg gcaacaccgc caagtgcacc agcaccggct ggatccccgc cccccgctgc      960

accctgaagc cctgcgacta ccccgacatc aagcacggcg gcctgtacca cgagaacatg     1020

cgccgcccct acttccccgt ggccgtgggc aagtactaca gctactactg cgacgagcac     1080

ttcgagaccc ccagcggcag ctactgggac cacatccact gcacccagga cggctggagc     1140

cccgccgtgc cctgcctgcg caagtgctac ttcccctacc tggagaacgg ctacaaccag     1200

aactacggcc gcaagttcgt gcagggcaag agcatcgacg tggcctgcca ccccggctac     1260

gccctgccca aggcccagac caccgtgacc tgcatggaga acggctggag ccccaccccc     1320

cgctgcatcc gccgccgcag caagcgcagc ggcagcggcg ccaccaactt cagcctgctg     1380

aagcaggccg gcgacgtgga ggagaacccc ggccccatgc gccgcctgct gaccttcatc     1440

agcatcctgg ccctggtggg cgccgccttc gccagcgaca ccggccgccc cttcgtggag     1500

atgtacagcg agatccccga gatcatccac atgaccgagg gccgcgagct ggtgatcccc     1560

tgccgcgtga ccagccccaa catcaccgtg accctgaaga agttccccct ggacaccctg     1620

atccccgacg gcaagcgcat catctgggac agccgcaagg gcttcatcat cagcaacgcc     1680

acctacaagg agatcggcct gctgacctgc gaggccaccg tgaacggcca cctgtacaag     1740

accaactacc tgacccaccg ccagaccaac accatcatcg acgtggtgct gagccccagc     1800

cacggcatcg agctgagcgt gggcgagaag ctggtgctga actgcaccgc ccgcaccgag     1860

ctgaacgtgg gcatcgactt caactgggag taccccagca gcaagcacca gcacaagaag     1920

ctggtgaacc gcgacctgaa gacccagagc ggcagcgaga tgaagaagtt cctgagcacc     1980

ctgaccatcg acggcgtgac ccgcagcgac cagggcctgt acacctgcgc cgccagcagc     2040

ggcctgatga ccaagaagaa cagcaccttc gtgcgcgtgc acgagaagga caagacccac     2100

acctgccccc cctgccccgc ccccgaggcc gccggcggcc ccagcgtgtt cctgttcccc     2160

cccaagccca aggacaccct gatgatcagc cgcacccccg aggtgacctg cgtggtggtg     2220

gacgtgagcc acgaggaccc cgaggtgaag ttcaactggt acgtggacgg cgtggaggtg     2280

cacaacgcca agaccaagcc ccgcgaggag cagtacaaca gcacctaccg cgtggtgagc     2340

gtgctgaccg tgctggccca ggactggctg aacggcaagg agtacaagtg caaggtgagc     2400

aacaaggccc tgggcgcccc catcgagaag accatcagca aggccaaggg ccagccccgc     2460

gagccccagg tgtacaccct gccccccagc cgcgacgagc tgaccaagaa ccaggtgagc     2520

ctgacctgcc tggtgaaggg cttctacccc agcgacatcg ccgtggagtg ggagagcaac     2580

ggccagcccg agaacaacta caagaccacc ccccccgtgc tggacagcga cggcagcttc     2640

ttcctgtaca gcaagctgac cgtggacaag agccgctggc agcagggcaa cgtgttcagc     2700

tgcagcgtga tgcacgaggc cctgcacaac gcctacaccc agaagagcct gagcctgagc     2760

cccggc                                                                2766


<210>  104
<211>  807
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VEGF capture protein 2-furin-P2A-sCD46

<400>  104

Met Arg Arg Leu Leu Thr Phe Ile Ser Ile Leu Ala Leu Val Gly Ala 
1               5                   10                  15      


Ala Phe Ala Ser Asp Thr Gly Arg Pro Phe Val Glu Met Tyr Ser Glu 
            20                  25                  30          


Ile Pro Glu Ile Ile His Met Thr Glu Gly Arg Glu Leu Val Ile Pro 
        35                  40                  45              


Cys Arg Val Thr Ser Pro Asn Ile Thr Val Thr Leu Lys Lys Phe Pro 
    50                  55                  60                  


Leu Asp Thr Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp Asp Ser Arg 
65                  70                  75                  80  


Lys Gly Phe Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile Gly Leu Leu 
                85                  90                  95      


Thr Cys Glu Ala Thr Val Asn Gly His Leu Tyr Lys Thr Asn Tyr Leu 
            100                 105                 110         


Thr His Arg Gln Thr Asn Thr Ile Ile Asp Val Val Leu Ser Pro Ser 
        115                 120                 125             


His Gly Ile Glu Leu Ser Val Gly Glu Lys Leu Val Leu Asn Cys Thr 
    130                 135                 140                 


Ala Arg Thr Glu Leu Asn Val Gly Ile Asp Phe Asn Trp Glu Tyr Pro 
145                 150                 155                 160 


Ser Ser Lys His Gln His Lys Lys Leu Val Asn Arg Asp Leu Lys Thr 
                165                 170                 175     


Gln Ser Gly Ser Glu Met Lys Lys Phe Leu Ser Thr Leu Thr Ile Asp 
            180                 185                 190         


Gly Val Thr Arg Ser Asp Gln Gly Leu Tyr Thr Cys Ala Ala Ser Ser 
        195                 200                 205             


Gly Leu Met Thr Lys Lys Asn Ser Thr Phe Val Arg Val His Glu Lys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu Ala Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn Ala Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Arg Arg Ser Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser 
    450                 455                 460                 


Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Arg 
465                 470                 475                 480 


Arg Phe Leu Thr Val Ile Ser Phe Leu Leu Tyr Phe Gly Cys Ala Phe 
                485                 490                 495     


Ala Cys Glu Glu Pro Pro Thr Phe Glu Ala Met Glu Leu Ile Gly Lys 
            500                 505                 510         


Pro Lys Pro Tyr Tyr Glu Ile Gly Glu Arg Val Asp Tyr Lys Cys Lys 
        515                 520                 525             


Lys Gly Tyr Phe Tyr Ile Pro Pro Leu Ala Thr His Thr Ile Cys Asp 
    530                 535                 540                 


Arg Asn His Thr Trp Leu Pro Val Ser Asp Asp Ala Cys Tyr Arg Glu 
545                 550                 555                 560 


Thr Cys Pro Tyr Ile Arg Asp Pro Leu Asn Gly Gln Ala Val Pro Ala 
                565                 570                 575     


Asn Gly Thr Tyr Glu Phe Gly Tyr Gln Met His Phe Ile Cys Asn Glu 
            580                 585                 590         


Gly Tyr Tyr Leu Ile Gly Glu Glu Ile Leu Tyr Cys Glu Leu Lys Gly 
        595                 600                 605             


Ser Val Ala Ile Trp Ser Gly Lys Pro Pro Ile Cys Glu Lys Val Leu 
    610                 615                 620                 


Cys Thr Pro Pro Pro Lys Ile Lys Asn Gly Lys His Thr Phe Ser Glu 
625                 630                 635                 640 


Val Glu Val Phe Glu Tyr Leu Asp Ala Val Thr Tyr Ser Cys Asp Pro 
                645                 650                 655     


Ala Pro Gly Pro Asp Pro Phe Ser Leu Ile Gly Glu Ser Thr Ile Tyr 
            660                 665                 670         


Cys Gly Asp Asn Ser Val Trp Ser Arg Ala Ala Pro Glu Cys Lys Val 
        675                 680                 685             


Val Lys Cys Arg Phe Pro Val Val Glu Asn Gly Lys Gln Ile Ser Gly 
    690                 695                 700                 


Phe Gly Lys Lys Phe Tyr Tyr Lys Ala Thr Val Met Phe Glu Cys Asp 
705                 710                 715                 720 


Lys Gly Phe Tyr Leu Asp Gly Ser Asp Thr Ile Val Cys Asp Ser Asn 
                725                 730                 735     


Ser Thr Trp Asp Pro Pro Val Pro Lys Cys Leu Lys Val Leu Pro Pro 
            740                 745                 750         


Ser Ser Thr Lys Pro Pro Ala Leu Ser His Ser Val Ser Thr Ser Ser 
        755                 760                 765             


Thr Thr Lys Ser Pro Ala Ser Ser Ala Ser Gly Pro Arg Pro Thr Tyr 
    770                 775                 780                 


Lys Pro Pro Val Ser Asn Tyr Pro Gly Tyr Pro Lys Pro Glu Glu Gly 
785                 790                 795                 800 


Ile Leu Asp Ser Leu Asp Val 
                805         


<210>  105
<211>  2424
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence encoding VEGF capture protein 
       2-furin-P2A-sCD46

<400>  105
atgcgccgcc tgctgacctt catcagcatc ctggccctgg tgggcgccgc cttcgccagc       60

gacaccggcc gccccttcgt ggagatgtac agcgagatcc ccgagatcat ccacatgacc      120

gagggccgcg agctggtgat cccctgccgc gtgaccagcc ccaacatcac cgtgaccctg      180

aagaagttcc ccctggacac cctgatcccc gacggcaagc gcatcatctg ggacagccgc      240

aagggcttca tcatcagcaa cgccacctac aaggagatcg gcctgctgac ctgcgaggcc      300

accgtgaacg gccacctgta caagaccaac tacctgaccc accgccagac caacaccatc      360

atcgacgtgg tgctgagccc cagccacggc atcgagctga gcgtgggcga gaagctggtg      420

ctgaactgca ccgcccgcac cgagctgaac gtgggcatcg acttcaactg ggagtacccc      480

agcagcaagc accagcacaa gaagctggtg aaccgcgacc tgaagaccca gagcggcagc      540

gagatgaaga agttcctgag caccctgacc atcgacggcg tgacccgcag cgaccagggc      600

ctgtacacct gcgccgccag cagcggcctg atgaccaaga agaacagcac cttcgtgcgc      660

gtgcacgaga aggacaagac ccacacctgc cccccctgcc ccgcccccga ggccgccggc      720

ggccccagcg tgttcctgtt cccccccaag cccaaggaca ccctgatgat cagccgcacc      780

cccgaggtga cctgcgtggt ggtggacgtg agccacgagg accccgaggt gaagttcaac      840

tggtacgtgg acggcgtgga ggtgcacaac gccaagacca agccccgcga ggagcagtac      900

aacagcacct accgcgtggt gagcgtgctg accgtgctgg cccaggactg gctgaacggc      960

aaggagtaca agtgcaaggt gagcaacaag gccctgggcg cccccatcga gaagaccatc     1020

agcaaggcca agggccagcc ccgcgagccc caggtgtaca ccctgccccc cagccgcgac     1080

gagctgacca agaaccaggt gagcctgacc tgcctggtga agggcttcta ccccagcgac     1140

atcgccgtgg agtgggagag caacggccag cccgagaaca actacaagac cacccccccc     1200

gtgctggaca gcgacggcag cttcttcctg tacagcaagc tgaccgtgga caagagccgc     1260

tggcagcagg gcaacgtgtt cagctgcagc gtgatgcacg aggccctgca caacgcctac     1320

acccagaaga gcctgagcct gagccccggc cgccgcagca agcgcagcgg cagcggcgcc     1380

accaacttca gcctgctgaa gcaggccggc gacgtggagg agaaccccgg ccccatgcgc     1440

cgcttcctga ccgtgatcag cttcctgctg tacttcggct gcgccttcgc ctgcgaggag     1500

ccccccacct tcgaggccat ggagctgatc ggcaagccca agccctacta cgagatcggc     1560

gagcgcgtgg actacaagtg caagaagggc tacttctaca tcccccccct ggccacccac     1620

accatctgcg accgcaacca cacctggctg cccgtgagcg acgacgcctg ctaccgcgag     1680

acctgcccct acatccgcga ccccctgaac ggccaggccg tgcccgccaa cggcacctac     1740

gagttcggct accagatgca cttcatctgc aacgagggct actacctgat cggcgaggag     1800

atcctgtact gcgagctgaa gggcagcgtg gccatctgga gcggcaagcc ccccatctgc     1860

gagaaggtgc tgtgcacccc cccccccaag atcaagaacg gcaagcacac cttcagcgag     1920

gtggaggtgt tcgagtacct ggacgccgtg acctacagct gcgaccccgc ccccggcccc     1980

gaccccttca gcctgatcgg cgagagcacc atctactgcg gcgacaacag cgtgtggagc     2040

cgcgccgccc ccgagtgcaa ggtggtgaag tgccgcttcc ccgtggtgga gaacggcaag     2100

cagatcagcg gcttcggcaa gaagttctac tacaaggcca ccgtgatgtt cgagtgcgac     2160

aagggcttct acctggacgg cagcgacacc atcgtgtgcg acagcaacag cacctgggac     2220

ccccccgtgc ccaagtgcct gaaggtgctg ccccccagca gcaccaagcc ccccgccctg     2280

agccacagcg tgagcaccag cagcaccacc aagagccccg ccagcagcgc cagcggcccc     2340

cgccccacct acaagccccc cgtgagcaac taccccggct accccaagcc cgaggagggc     2400

atcctggaca gcctggacgt gtaa                                            2424


<210>  106
<211>  807
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sCD46-furin-P2A-VEGF capture protein 2

<400>  106

Met Arg Arg Phe Leu Thr Val Ile Ser Phe Leu Leu Tyr Phe Gly Cys 
1               5                   10                  15      


Ala Phe Ala Cys Glu Glu Pro Pro Thr Phe Glu Ala Met Glu Leu Ile 
            20                  25                  30          


Gly Lys Pro Lys Pro Tyr Tyr Glu Ile Gly Glu Arg Val Asp Tyr Lys 
        35                  40                  45              


Cys Lys Lys Gly Tyr Phe Tyr Ile Pro Pro Leu Ala Thr His Thr Ile 
    50                  55                  60                  


Cys Asp Arg Asn His Thr Trp Leu Pro Val Ser Asp Asp Ala Cys Tyr 
65                  70                  75                  80  


Arg Glu Thr Cys Pro Tyr Ile Arg Asp Pro Leu Asn Gly Gln Ala Val 
                85                  90                  95      


Pro Ala Asn Gly Thr Tyr Glu Phe Gly Tyr Gln Met His Phe Ile Cys 
            100                 105                 110         


Asn Glu Gly Tyr Tyr Leu Ile Gly Glu Glu Ile Leu Tyr Cys Glu Leu 
        115                 120                 125             


Lys Gly Ser Val Ala Ile Trp Ser Gly Lys Pro Pro Ile Cys Glu Lys 
    130                 135                 140                 


Val Leu Cys Thr Pro Pro Pro Lys Ile Lys Asn Gly Lys His Thr Phe 
145                 150                 155                 160 


Ser Glu Val Glu Val Phe Glu Tyr Leu Asp Ala Val Thr Tyr Ser Cys 
                165                 170                 175     


Asp Pro Ala Pro Gly Pro Asp Pro Phe Ser Leu Ile Gly Glu Ser Thr 
            180                 185                 190         


Ile Tyr Cys Gly Asp Asn Ser Val Trp Ser Arg Ala Ala Pro Glu Cys 
        195                 200                 205             


Lys Val Val Lys Cys Arg Phe Pro Val Val Glu Asn Gly Lys Gln Ile 
    210                 215                 220                 


Ser Gly Phe Gly Lys Lys Phe Tyr Tyr Lys Ala Thr Val Met Phe Glu 
225                 230                 235                 240 


Cys Asp Lys Gly Phe Tyr Leu Asp Gly Ser Asp Thr Ile Val Cys Asp 
                245                 250                 255     


Ser Asn Ser Thr Trp Asp Pro Pro Val Pro Lys Cys Leu Lys Val Leu 
            260                 265                 270         


Pro Pro Ser Ser Thr Lys Pro Pro Ala Leu Ser His Ser Val Ser Thr 
        275                 280                 285             


Ser Ser Thr Thr Lys Ser Pro Ala Ser Ser Ala Ser Gly Pro Arg Pro 
    290                 295                 300                 


Thr Tyr Lys Pro Pro Val Ser Asn Tyr Pro Gly Tyr Pro Lys Pro Glu 
305                 310                 315                 320 


Glu Gly Ile Leu Asp Ser Leu Asp Val Arg Arg Ser Lys Arg Ser Gly 
                325                 330                 335     


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
            340                 345                 350         


Glu Asn Pro Gly Pro Met Arg Arg Leu Leu Thr Phe Ile Ser Ile Leu 
        355                 360                 365             


Ala Leu Val Gly Ala Ala Phe Ala Ser Asp Thr Gly Arg Pro Phe Val 
    370                 375                 380                 


Glu Met Tyr Ser Glu Ile Pro Glu Ile Ile His Met Thr Glu Gly Arg 
385                 390                 395                 400 


Glu Leu Val Ile Pro Cys Arg Val Thr Ser Pro Asn Ile Thr Val Thr 
                405                 410                 415     


Leu Lys Lys Phe Pro Leu Asp Thr Leu Ile Pro Asp Gly Lys Arg Ile 
            420                 425                 430         


Ile Trp Asp Ser Arg Lys Gly Phe Ile Ile Ser Asn Ala Thr Tyr Lys 
        435                 440                 445             


Glu Ile Gly Leu Leu Thr Cys Glu Ala Thr Val Asn Gly His Leu Tyr 
    450                 455                 460                 


Lys Thr Asn Tyr Leu Thr His Arg Gln Thr Asn Thr Ile Ile Asp Val 
465                 470                 475                 480 


Val Leu Ser Pro Ser His Gly Ile Glu Leu Ser Val Gly Glu Lys Leu 
                485                 490                 495     


Val Leu Asn Cys Thr Ala Arg Thr Glu Leu Asn Val Gly Ile Asp Phe 
            500                 505                 510         


Asn Trp Glu Tyr Pro Ser Ser Lys His Gln His Lys Lys Leu Val Asn 
        515                 520                 525             


Arg Asp Leu Lys Thr Gln Ser Gly Ser Glu Met Lys Lys Phe Leu Ser 
    530                 535                 540                 


Thr Leu Thr Ile Asp Gly Val Thr Arg Ser Asp Gln Gly Leu Tyr Thr 
545                 550                 555                 560 


Cys Ala Ala Ser Ser Gly Leu Met Thr Lys Lys Asn Ser Thr Phe Val 
                565                 570                 575     


Arg Val His Glu Lys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
            580                 585                 590         


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
        595                 600                 605             


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
    610                 615                 620                 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
625                 630                 635                 640 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
                645                 650                 655     


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu Ala Gln 
            660                 665                 670         


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
        675                 680                 685             


Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
    690                 695                 700                 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
705                 710                 715                 720 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
                725                 730                 735     


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
            740                 745                 750         


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
        755                 760                 765             


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
    770                 775                 780                 


Ser Cys Ser Val Met His Glu Ala Leu His Asn Ala Tyr Thr Gln Lys 
785                 790                 795                 800 


Ser Leu Ser Leu Ser Pro Gly 
                805         


<210>  107
<211>  2421
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence encoding sCD46-furin-P2A-VEGF capture 
       protein 2

<400>  107
atgcgccgct tcctgaccgt gatcagcttc ctgctgtact tcggctgcgc cttcgcctgc       60

gaggagcccc ccaccttcga ggccatggag ctgatcggca agcccaagcc ctactacgag      120

atcggcgagc gcgtggacta caagtgcaag aagggctact tctacatccc ccccctggcc      180

acccacacca tctgcgaccg caaccacacc tggctgcccg tgagcgacga cgcctgctac      240

cgcgagacct gcccctacat ccgcgacccc ctgaacggcc aggccgtgcc cgccaacggc      300

acctacgagt tcggctacca gatgcacttc atctgcaacg agggctacta cctgatcggc      360

gaggagatcc tgtactgcga gctgaagggc agcgtggcca tctggagcgg caagcccccc      420

atctgcgaga aggtgctgtg cacccccccc cccaagatca agaacggcaa gcacaccttc      480

agcgaggtgg aggtgttcga gtacctggac gccgtgacct acagctgcga ccccgccccc      540

ggccccgacc ccttcagcct gatcggcgag agcaccatct actgcggcga caacagcgtg      600

tggagccgcg ccgcccccga gtgcaaggtg gtgaagtgcc gcttccccgt ggtggagaac      660

ggcaagcaga tcagcggctt cggcaagaag ttctactaca aggccaccgt gatgttcgag      720

tgcgacaagg gcttctacct ggacggcagc gacaccatcg tgtgcgacag caacagcacc      780

tgggaccccc ccgtgcccaa gtgcctgaag gtgctgcccc ccagcagcac caagcccccc      840

gccctgagcc acagcgtgag caccagcagc accaccaaga gccccgccag cagcgccagc      900

ggcccccgcc ccacctacaa gccccccgtg agcaactacc ccggctaccc caagcccgag      960

gagggcatcc tggacagcct ggacgtgcgc cgcagcaagc gcagcggcag cggcgccacc     1020

aacttcagcc tgctgaagca ggccggcgac gtggaggaga accccggccc catgcgccgc     1080

ctgctgacct tcatcagcat cctggccctg gtgggcgccg ccttcgccag cgacaccggc     1140

cgccccttcg tggagatgta cagcgagatc cccgagatca tccacatgac cgagggccgc     1200

gagctggtga tcccctgccg cgtgaccagc cccaacatca ccgtgaccct gaagaagttc     1260

cccctggaca ccctgatccc cgacggcaag cgcatcatct gggacagccg caagggcttc     1320

atcatcagca acgccaccta caaggagatc ggcctgctga cctgcgaggc caccgtgaac     1380

ggccacctgt acaagaccaa ctacctgacc caccgccaga ccaacaccat catcgacgtg     1440

gtgctgagcc ccagccacgg catcgagctg agcgtgggcg agaagctggt gctgaactgc     1500

accgcccgca ccgagctgaa cgtgggcatc gacttcaact gggagtaccc cagcagcaag     1560

caccagcaca agaagctggt gaaccgcgac ctgaagaccc agagcggcag cgagatgaag     1620

aagttcctga gcaccctgac catcgacggc gtgacccgca gcgaccaggg cctgtacacc     1680

tgcgccgcca gcagcggcct gatgaccaag aagaacagca ccttcgtgcg cgtgcacgag     1740

aaggacaaga cccacacctg ccccccctgc cccgcccccg aggccgccgg cggccccagc     1800

gtgttcctgt tcccccccaa gcccaaggac accctgatga tcagccgcac ccccgaggtg     1860

acctgcgtgg tggtggacgt gagccacgag gaccccgagg tgaagttcaa ctggtacgtg     1920

gacggcgtgg aggtgcacaa cgccaagacc aagccccgcg aggagcagta caacagcacc     1980

taccgcgtgg tgagcgtgct gaccgtgctg gcccaggact ggctgaacgg caaggagtac     2040

aagtgcaagg tgagcaacaa ggccctgggc gcccccatcg agaagaccat cagcaaggcc     2100

aagggccagc cccgcgagcc ccaggtgtac accctgcccc ccagccgcga cgagctgacc     2160

aagaaccagg tgagcctgac ctgcctggtg aagggcttct accccagcga catcgccgtg     2220

gagtgggaga gcaacggcca gcccgagaac aactacaaga ccaccccccc cgtgctggac     2280

agcgacggca gcttcttcct gtacagcaag ctgaccgtgg acaagagccg ctggcagcag     2340

ggcaacgtgt tcagctgcag cgtgatgcac gaggccctgc acaacgccta cacccagaag     2400

agcctgagcc tgagccccgg c                                               2421


