                         SEQUENCE LISTING

<110>  Ikarovec Limited
 
<120>  Ocular Disorders

<130>  AXH/CKW/117965GB1

<150>  GB2108761.4
<151>  2021-06-18

<160>  49    

<170>  PatentIn version 3.5

<210>  1
<211>  508
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cytomegalovirus (CMV) promoter

<400>  1
cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt       60

gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca      120

atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc      180

aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta      240

catgacctta tgggactttc ctacttggca gtacatctac gtattagtca tcgctattac      300

catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg actcacgggg      360

atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc aaaatcaacg      420

ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg gtaggcgtgt      480

acggtgggag gtctatataa gcagagct                                         508


<210>  2
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  truncated form of the CMV promoter

<400>  2
aggtaggcgt gtacggtggg aggtctatat aagcagagct ggtttagtga accgtcagat       60


<210>  3
<211>  583
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence encoding the CMV early enhancer element and 
       the first intron of chicken beta-actin gene

<400>  3
cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt       60

gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca      120

atgggtggac tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc      180

aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta      240

catgacctta tgggactttc ctacttggca gtacatctac gtattagtca tcgctattac      300

catggtcgag gtgagcccca cgttctgctt cactctcccc atctcccccc cctccccacc      360

cccaattttg tatttattta ttttttaatt attttgtgca gcgatggggg cggggggggg      420

gggggggcgc gcgccaggcg gggcggggcg gggcgagggg cggggcgggg cgaggcggag      480

aggtgcggcg gcagccaatc agagcggcgc gctccgaaag tttcctttta tggcgaggcg      540

gcggcggcgg cggccctata aaaagcgaag cgcgcggcgg gcg                        583


<210>  4
<211>  500
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  murine phosphoglycerate kinase-1 (PGK-1) promoter

<400>  4
gggtagggga ggcgcttttc ccaaggcagt ctggagcatg cgctttagca gccccgctgg       60

gcacttggcg ctacacaagt ggcctctggc ctcgcacaca ttccacatcc accggtaggc      120

gccaaccggc tccgttcttt ggtggcccct tcgcgccacc ttctactcct cccctagtca      180

ggaagttccc ccccgccccg cagctcgcgt cgtgcaggac gtgacaaatg gaagtagcac      240

gtctcactag tctcgtgcag atggacagca ccgctgagca atggaagcgg gtaggccttt      300

ggggcagcgg ccaatagcag ctttgctcct tcgctttctg ggctcagagg ctgggaaggg      360

gtgggtccgg gggcgggctc aggggcgggc tcaggggcgg ggcgggcgcc cgaaggtcct      420

ccggaggccc ggcattctgc acgcttcaaa agcgcacgtc tgccgcgctg ttctcctctt      480

cctcatctcc gggcctttcg                                                  500


<210>  5
<211>  1182
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EF1alpha promoter

<400>  5
gctccggtgc ccgtcagtgg gcagagcgca catcgcccac agtccccgag aagttggggg       60

gaggggtcgg caattgaacc ggtgcctaga gaaggtggcg cggggtaaac tgggaaagtg      120

atgtcgtgta ctggctccgc ctttttcccg agggtggggg agaaccgtat ataagtgcag      180

tagtcgccgt gaacgttctt tttcgcaacg ggtttgccgc cagaacacag gtaagtgccg      240

tgtgtggttc ccgcgggcct ggcctcttta cgggttatgg cccttgcgtg ccttgaatta      300

cttccacgcc cctggctgca gtacgtgatt cttgatcccg agcttcgggt tggaagtggg      360

tgggagagtt cgaggccttg cgcttaagga gccccttcgc ctcgtgcttg agttgaggcc      420

tggcttgggc gctggggccg ccgcgtgcga atctggtggc accttcgcgc ctgtctcgct      480

gctttcgata agtctctagc catttaaaat ttttgatgac ctgctgcgac gctttttttc      540

tggcaagata gtcttgtaaa tgcgggccaa gatctgcaca ctggtatttc ggtttttggg      600

gccgcgggcg gcgacggggc ccgtgcgtcc cagcgcacat gttcggcgag gcggggcctg      660

cgagcgcggc caccgagaat cggacggggg tagtctcaag ctggccggcc tgctctggtg      720

cctggcctcg cgccgccgtg tatcgccccg ccctgggcgg caaggctggc ccggtcggca      780

ccagttgcgt gagcggaaag atggccgctt cccggccctg ctgcagggag ctcaaaatgg      840

aggacgcggc gctcgggaga gcgggcgggt gagtcaccca cacaaaggaa aagggccttt      900

ccgtcctcag ccgtcgcttc atgtgactcc acggagtacc gggcgccgtc caggcacctc      960

gattagttct cgagcttttg gagtacgtcg tctttaggtt ggggggaggg gttttatgcg     1020

atggagtttc cccacactga gtgggtggag actgaagtta ggccagcttg gcacttgatg     1080

taattctcct tggaatttgc cctttttgag tttggatctt ggttcattct caagcctcag     1140

acagtggttc aaagtttttt tcttccattt caggtgtcgt ga                        1182


<210>  6
<211>  230
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EF1alpha without the large intron promoter

<400>  6
gctccggtgc ccgtcagtgg gcagagcgca catcgcccac agtccccgag aagttggggg       60

gaggggtcgg caattgaacc ggtgcctaga gaaggtggcg cggggtaaac tgggaaagtg      120

atgtcgtgta ctggctccgc ctttttcccg agggtggggg agaaccgtat ataagtgcag      180

tagtcgccgt gaacgttctt tttcgcaacg ggtttgccgc cagaacacag                 230


<210>  7
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ang-1 fibrinogen-like domain

<400>  7

Arg Glu Glu Glu Lys Pro Phe Arg Asp Cys Ala Asp Val Tyr Gln Ala 
1               5                   10                  15      


Gly Phe Asn Lys Ser Gly Ile Tyr Thr Ile Tyr Ile Asn Asn Met Pro 
            20                  25                  30          


Glu Pro Lys Lys Val Phe Cys Asn Met Asp Val Asn Gly Gly Gly Trp 
        35                  40                  45              


Thr Val Ile Gln His Arg Glu Asp Gly Ser Leu Asp Phe Gln Arg Gly 
    50                  55                  60                  


Trp Lys Glu Tyr Lys Met Gly Phe Gly Asn Pro Ser Gly Glu Tyr Trp 
65                  70                  75                  80  


Leu Gly Asn Glu Phe Ile Phe Ala Ile Thr Ser Gln Arg Gln Tyr Met 
                85                  90                  95      


Leu Arg Ile Glu Leu Met Asp Trp Glu Gly Asn Arg Ala Tyr Ser Gln 
            100                 105                 110         


Tyr Asp Arg Phe His Ile Gly Asn Glu Lys Gln Asn Tyr Arg Leu Tyr 
        115                 120                 125             


Leu Lys Gly His Thr Gly Thr Ala Gly Lys Gln Ser Ser Leu Ile Leu 
    130                 135                 140                 


His Gly Ala Asp Phe Ser Thr Lys Asp Ala Asp Asn Asp Asn Cys Met 
145                 150                 155                 160 


Cys Lys Cys Ala Leu Met Leu Thr Gly Gly Trp Trp Phe Asp Ala Cys 
                165                 170                 175     


Gly Pro Ser Asn Leu Asn Gly Met Phe Tyr Thr Ala Gly Gln Asn His 
            180                 185                 190         


Gly Lys Leu Asn Gly Ile Lys Trp His Tyr Phe Lys Gly Pro Ser Tyr 
        195                 200                 205             


Ser Leu Arg Ser Thr Thr Met Met Ile Arg Pro Leu Asp Phe 
    210                 215                 220         


<210>  8
<211>  666
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence encoding Ang-1 fibrinogen-like domain

<400>  8
cgcgaggagg agaagccctt ccgcgactgc gccgacgtgt accaggccgg cttcaacaag       60

agcggcatct acaccatcta catcaacaac atgcccgagc ccaagaaggt gttctgcaac      120

atggacgtga acggcggcgg ctggaccgtg atccagcacc gcgaggacgg cagcctggac      180

ttccagcgcg gctggaagga gtacaagatg ggcttcggca accccagcgg cgagtactgg      240

ctgggcaacg agttcatctt cgccatcacc agccagcgcc agtacatgct gcgcatcgag      300

ctgatggact gggagggcaa ccgcgcctac agccagtacg accgcttcca catcggcaac      360

gagaagcaga actaccgcct gtacctgaag ggccacaccg gcaccgccgg caagcagagc      420

agcctgatcc tgcacggcgc cgacttcagc accaaggacg ccgacaacga caactgcatg      480

tgcaagtgcg ccctgatgct gaccggcggc tggtggttcg acgcctgcgg ccccagcaac      540

ctgaacggca tgttctacac cgccggccag aaccacggca agctgaacgg catcaagtgg      600

cactacttca agggccccag ctacagcctg cgcagcacca ccatgatgat ccgccccctg      660

gacttc                                                                 666


<210>  9
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ang-4 fibrinogen-like domain

<400>  9

Met Ala Gly Glu Gln Val Phe Gln Asp Cys Ala Glu Ile Gln Arg Ser 
1               5                   10                  15      


Gly Ala Ser Ala Ser Gly Val Tyr Thr Ile Gln Val Ser Asn Ala Thr 
            20                  25                  30          


Lys Pro Arg Lys Val Phe Cys Asp Leu Gln Ser Ser Gly Gly Arg Trp 
        35                  40                  45              


Thr Leu Ile Gln Arg Arg Glu Asn Gly Thr Val Asn Phe Gln Arg Asn 
    50                  55                  60                  


Trp Lys Asp Tyr Lys Gln Gly Phe Gly Asp Pro Ala Gly Glu His Trp 
65                  70                  75                  80  


Leu Gly Asn Glu Val Val His Gln Leu Thr Arg Arg Ala Ala Tyr Ser 
                85                  90                  95      


Leu Arg Val Glu Leu Gln Asp Trp Glu Gly His Glu Ala Tyr Ala Gln 
            100                 105                 110         


Tyr Glu His Phe His Leu Gly Ser Glu Asn Gln Leu Tyr Arg Leu Ser 
        115                 120                 125             


Val Val Gly Tyr Ser Gly Ser Ala Gly Arg Gln Ser Ser Leu Val Leu 
    130                 135                 140                 


Gln Asn Thr Ser Phe Ser Thr Leu Asp Ser Asp Asn Asp His Cys Leu 
145                 150                 155                 160 


Cys Lys Cys Ala Gln Val Met Ser Gly Gly Trp Trp Phe Asp Ala Cys 
                165                 170                 175     


Gly Leu Ser Asn Leu Asn Gly Val Tyr Tyr His Ala Pro Asp Asn Lys 
            180                 185                 190         


Tyr Lys Met Asp Gly Ile Arg Trp His Tyr Phe Lys Gly Pro Ser Tyr 
        195                 200                 205             


Ser Leu Arg Ala Ser Arg Met Met Ile Arg Pro Leu Asp Phe 
    210                 215                 220         


<210>  10
<211>  666
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence encoding Ang-4 fibrinogen-like domain

<400>  10
atggccggcg agcaggtgtt ccaggactgc gccgagatcc agcgcagcgg cgccagcgcc       60

agcggcgtgt acaccatcca ggtgagcaac gccaccaagc cccgcaaggt gttctgcgac      120

ctgcagagca gcggcggccg ctggaccctg atccagcgcc gcgagaacgg caccgtgaac      180

ttccagcgca actggaagga ctacaagcag ggcttcggcg accccgccgg cgagcactgg      240

ctgggcaacg aggtggtgca ccagctgacc cgccgcgccg cctacagcct gcgcgtggag      300

ctgcaggact gggagggcca cgaggcctac gcccagtacg agcacttcca cctgggcagc      360

gagaaccagc tgtaccgcct gagcgtggtg ggctacagcg gcagcgccgg ccgccagagc      420

agcctggtgc tgcagaacac cagcttcagc accctggaca gcgacaacga ccactgcctg      480

tgcaagtgcg cccaggtgat gagcggcggc tggtggttcg acgcctgcgg cctgagcaac      540

ctgaacggcg tgtactacca cgcccccgac aacaagtaca agatggacgg catccgctgg      600

cactacttca agggccccag ctacagcctg cgcgccagcc gcatgatgat ccgccccctg      660

gacttc                                                                 666


<210>  11
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  coiled-coil region derived from human fibrinogen-like protein-1

<400>  11

Leu Glu Asp Cys Ala Gln Glu Gln Met Arg Leu Arg Ala Gln Val Arg 
1               5                   10                  15      


Leu Leu Glu Thr Arg Val Lys Gln Gln Gln Val Lys Ile Lys Gln Leu 
            20                  25                  30          


Leu Gln Glu Asn Glu Val Gln 
        35                  


<210>  12
<211>  117
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence encoding coiled-coil region derived from 
       human fibrinogen-like protein-1

<400>  12
ctggaggact gcgcccagga gcagatgcgc ctgcgcgccc aggtgcgcct gctggagacc       60

cgcgtgaagc agcagcaggt gaagatcaag cagctgctgc aggagaacga ggtgcag         117


<210>  13
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  coiled-coil region derived from human tenascin-R

<400>  13

Cys Ala Ser Ser Ala Gln Val Leu Gln Glu Leu Leu Ser Arg Ile Glu 
1               5                   10                  15      


Met Leu Glu Arg Glu Val Ser Val Leu Arg Asp Gln Cys Asn 
            20                  25                  30  


<210>  14
<211>  90
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence encoding coiled-coil region derived from 
       human tenascin-R

<400>  14
tgcgccagca gcgcccaggt gctgcaggag ctgctgagcc gcatcgagat gctggagcgc       60

gaggtgagcg tgctgcgcga ccagtgcaac                                        90


<210>  15
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  coiled-coil region derived from human pentraxin-related protein 
       PTX3

<400>  15

Leu Gln Ala Thr Asp Asp Val Leu Arg Gly Glu Leu Gln Arg Leu Arg 
1               5                   10                  15      


Glu Glu Leu Gly Arg Leu Ala Glu Ser Leu Ala Arg 
            20                  25              


<210>  16
<211>  84
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence encoding coiled-coil region derived from 
       human pentraxin-related protein PTX3

<400>  16
ctgcaggcca ccgacgacgt gctgcgcggc gagctgcagc gcctgcgcga ggagctgggc       60

cgcctggccg agagcctggc ccgc                                              84


<210>  17
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  coiled-coil region derived from human pentraxin-related protein 
       PTX3

<400>  17

Glu Glu Ala Gly Arg Ala Leu Ala Ala Val Leu Glu Glu Leu Arg Gln 
1               5                   10                  15      


Thr Arg Ala Asp Leu His Ala Val Gln 
            20                  25  


<210>  18
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence encoding coiled-coil region derived from 
       human pentraxin-related protein PTX3 of SEQ ID NO: 17

<400>  18
gaggaggccg gccgcgccct ggccgccgtg ctggaggagc tgcgccagac ccgcgccgac       60

ctgcacgccg tgcag                                                        75


<210>  19
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  coiled-coil region derived from human matrilin

<400>  19

Gln Ala Lys Val Glu Gly Leu Leu Gln Ala Leu Thr Arg Lys Leu Glu 
1               5                   10                  15      


Ala Val Ser Lys Arg Leu Ala Ile Leu Glu Asn Thr Val 
            20                  25                  


<210>  20
<211>  87
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence encoding coiled-coil region derived from 
       human matrilin

<400>  20
caggccaagg tggagggcct gctgcaggcc ctgacccgca agctggaggc cgtgagcaag       60

cgcctggcca tcctggagaa caccgtg                                           87


<210>  21
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  coiled-coil region derived from human fibrinogen-like protein-2

<400>  21

Glu Glu Val Phe Lys Glu Val Gln Asn Leu Lys Glu Ile Val Asn Ser 
1               5                   10                  15      


Leu Lys Lys Ser Cys Gln Asp Cys Lys Leu Gln 
            20                  25          


<210>  22
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence encoding coiled-coil region derived from 
       human fibrinogen-like protein-2

<400>  22
gaggaggtgt tcaaggaggt gcagaacctg aaggagatcg tgaacagcct gaagaagagc       60

tgccaggact gcaagctgca g                                                 81


<210>  23
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  coiled-coil region derived from human matrilin-3

<400>  23

Asp Lys Val Ser Ser Tyr Leu Gln Arg Leu Asn Thr Lys Leu Asp Asp 
1               5                   10                  15      


Ile Leu Glu Lys Leu Lys Ile Asn Glu 
            20                  25  


<210>  24
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence encoding coiled-coil region derived from 
       human matrilin-3

<400>  24
gacaaggtga gcagctacct gcagcgcctg aacaccaagc tggacgacat cctggagaag       60

ctgaagatca acgag                                                        75


<210>  25
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  coiled-coil region derived from human collectin-11

<400>  25

Cys Ser Gln Leu Arg Lys Ala Ile Gly Glu Met Asp Asn Gln Val Ser 
1               5                   10                  15      


Gln Leu Thr Ser Glu Leu Lys Phe Ile Lys Asn Ala Val Ala Gly Val 
            20                  25                  30          


Arg Glu 
        


<210>  26
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence encoding coiled-coil region derived from 
       human collectin-11

<400>  26
tgcagccagc tgcgcaaggc catcggcgag atggacaacc aggtgagcca gctgaccagc       60

gagctgaagt tcatcaagaa cgccgtggcc ggcgtgcgcg ag                         102


<210>  27
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  coiled-coil region derived from human interferon-kappa

<400>  27

Leu Asp Gln Gln Ala Glu Tyr Leu Asn Gln Cys Leu Glu Glu Asp Lys 
1               5                   10                  15      


Asn Glu Asn Glu Asp Met Lys Glu Met Lys Glu Asn Glu Met Lys 
            20                  25                  30      


<210>  28
<211>  93
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence encoding coiled-coil region derived from 
       human interferon-kappa

<400>  28
ctggaccagc aggccgagta cctgaaccag tgcctggagg aggacaagaa cgagaacgag       60

gacatgaagg agatgaagga gaacgagatg aag                                    93


<210>  29
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  coiled-coil region derived from human emilin-1

<400>  29

Ala His Gly Asp Glu Gly Cys Gly Ala Cys Gly Gly Val Gln Glu Glu 
1               5                   10                  15      


Leu Gly Arg Leu Arg Asp Gly Val Glu Arg Cys Ser 
            20                  25              


<210>  30
<211>  84
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence encoding coiled-coil region derived from 
       human emilin-1

<400>  30
gcccacggcg acgagggctg cggcgcctgc ggcggcgtgc aggaggagct gggccgcctg       60

cgcgacggcg tggagcgctg cagc                                              84


<210>  31
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  coiled-coil region derived from human emilin-1

<400>  31

Gly Pro Pro Gly Ser Pro Gly Lys Asp Gly Gln Glu Gly Pro Ile Gly 
1               5                   10                  15      


Pro Pro Gly Pro Gln Gly Glu 
            20              


<210>  32
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence encoding coiled-coil region derived from 
       human emilin-1 of SEQ ID NO: 31

<400>  32
ggcccccccg gcagccccgg caaggacggc caggagggcc ccatcggccc ccccggcccc       60

cagggcgag                                                               69


<210>  33
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  coiled-coil region derived from human angiopoietin-related 
       protein-5

<400>  33

Leu Arg Asn Met Met Asp Glu Gln Gln Ala Ser Leu Asp Tyr Leu Ser 
1               5                   10                  15      


Asn Gln Val Asn Glu Leu Met Asn Arg Val 
            20                  25      


<210>  34
<211>  78
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence encoding coiled-coil region derived from 
       human angiopoietin-related protein-5

<400>  34
ctgcgcaaca tgatggacga gcagcaggcc agcctggact acctgagcaa ccaggtgaac       60

gagctgatga accgcgtg                                                     78


<210>  35
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protein linker

<400>  35

Leu Val Asn Leu Cys Thr Lys Glu Gly Val Leu Leu Lys Gly Gly Lys 
1               5                   10                  15      


<210>  36
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence encoding protein linker of SEQ ID NO: 35

<400>  36
ctggtgaacc tgtgcaccaa ggagggcgtg ctgctgaagg gcggcaag                    48


<210>  37
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protein linker

<400>  37

Thr Lys Glu Gly Val Leu Leu Lys Gly Gly Lys 
1               5                   10      


<210>  38
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence encoding protein linker of SEQ ID NO: 37

<400>  38
accaaggagg gcgtgctgct gaagggcggc aag                                    33


<210>  39
<211>  592
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Woodchuck Hepatitis Virus Post-transcriptional Regulatory Element
       (WPRE)

<400>  39
aatcaacctc tggattacaa aatttgtgaa agattgactg gtattcttaa ctatgttgct       60

ccttttacgc tatgtggata cgctgcttta atgcctttgt atcatgctat tgcttcccgt      120

atggctttca ttttctcctc cttgtataaa tcctggttgc tgtctcttta tgaggagttg      180

tggcccgttg tcaggcaacg tggcgtggtg tgcactgtgt ttgctgacgc aacccccact      240

ggttggggca ttgccaccac ctgtcagctc ctttccggga ctttcgcttt ccccctccct      300

attgccacgg cggaactcat cgccgcctgc cttgcccgct gctggacagg ggctcggctg      360

ttgggcactg acaattccgt ggtgttgtcg gggaagctga cgtcctttcc atggctgctc      420

gcctgtgttg ccacctggat tctgcgcggg acgtccttct gctacgtccc ttcggccctc      480

aatccagcgg accttccttc ccgcggcctg ctgccggctc tgcggcctct tccgcgtctt      540

cgccttcgcc ctcagacgag tcggatctcc ctttgggccg cctccccgcc tg              592


<210>  40
<211>  247
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  truncated WPRE

<400>  40
aatcaacctc tggattacaa aatttgtgaa agattgactg gtattcttaa ctatgttgct       60

ccttttacgc tatgtggata cgctgcttta atgcctttgt atcatgctat tgcttcccgt      120

atggctttca ttttctcctc cttgtataaa tcctggttag ttcttgccac ggcggaactc      180

atcgccgcct gccttgcccg ctgctggaca ggggctcggc tgttgggcac tgacaattcc      240

gtggtgt                                                                247


<210>  41
<211>  224
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  simian virus-40 poly-A nucleotide sequence

<400>  41
agcagacatg ataagataca ttgatgagtt tggacaaacc acaactagaa tgcagtgaaa       60

aaaatgcttt atttgtgaaa tttgtgatgc tattgcttta tttgtaacca ttataagctg      120

caataaacaa gttaacaaca acaattgcat tcattttatg tttcaggttc agggggaggt      180

gtgggaggtt ttttaaagca agtaaaacct ctacaaatgt ggta                       224


<210>  42
<211>  169
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  poly-A component

<400>  42
ttcgagcaac ttgtttattg cagcttataa tggttacaaa taaagcaata gcatcacaaa       60

tttcacaaat aaagcatttt tttcactgca ttctagttgt ggtttgtcca aactcatcaa      120

tgtatcttat catgtctgga tcgtctagca tcgaagatcc cccgatctg                  169


<210>  43
<211>  103
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  left ITR from a commercially available AAV plasmid

<400>  43
cgcgctcgct cgctcactga ggccgcccgg gcaaagcccg ggcgtcgggc gacctttggt       60

cgcccggcct cagtgagcga gcgagcgcgc agagagggag tgg                        103


<210>  44
<211>  128
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  right ITR from a commercially available AAV plasmid

<400>  44
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg       60

ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc      120

gagcgcgc                                                               128


<210>  45
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal peptide coding sequence

<400>  45

Met Arg Arg Leu Leu Ile Leu Ala Leu Val Gly Ala Ala Val Ala 
1               5                   10                  15  


<210>  46
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence encoding signal peptide coding sequence

<400>  46
atgcgccgct tcctgaccgt gatcagcttc ctgctgtact tcggctgcgc cttcgcc          57


<210>  47
<211>  273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IKC076V construct

<400>  47

Met Arg Arg Leu Leu Ile Leu Ala Leu Val Gly Ala Ala Val Ala Glu 
1               5                   10                  15      


Glu Ala Gly Arg Ala Leu Ala Ala Val Leu Glu Glu Leu Arg Gln Thr 
            20                  25                  30          


Arg Ala Asp Leu His Ala Val Gln Thr Lys Glu Gly Val Leu Leu Lys 
        35                  40                  45              


Gly Gly Lys Arg Glu Glu Glu Lys Pro Phe Arg Asp Cys Ala Asp Val 
    50                  55                  60                  


Tyr Gln Ala Gly Phe Asn Lys Ser Gly Ile Tyr Thr Ile Tyr Ile Asn 
65                  70                  75                  80  


Asn Met Pro Glu Pro Lys Lys Val Phe Cys Asn Met Asp Val Asn Gly 
                85                  90                  95      


Gly Gly Trp Thr Val Ile Gln His Arg Glu Asp Gly Ser Leu Asp Phe 
            100                 105                 110         


Gln Arg Gly Trp Lys Glu Tyr Lys Met Gly Phe Gly Asn Pro Ser Gly 
        115                 120                 125             


Glu Tyr Trp Leu Gly Asn Glu Phe Ile Phe Ala Ile Thr Ser Gln Arg 
    130                 135                 140                 


Gln Tyr Met Leu Arg Ile Glu Leu Met Asp Trp Glu Gly Asn Arg Ala 
145                 150                 155                 160 


Tyr Ser Gln Tyr Asp Arg Phe His Ile Gly Asn Glu Lys Gln Asn Tyr 
                165                 170                 175     


Arg Leu Tyr Leu Lys Gly His Thr Gly Thr Ala Gly Lys Gln Ser Ser 
            180                 185                 190         


Leu Ile Leu His Gly Ala Asp Phe Ser Thr Lys Asp Ala Asp Asn Asp 
        195                 200                 205             


Asn Cys Met Cys Lys Cys Ala Leu Met Leu Thr Gly Gly Trp Trp Phe 
    210                 215                 220                 


Asp Ala Cys Gly Pro Ser Asn Leu Asn Gly Met Phe Tyr Thr Ala Gly 
225                 230                 235                 240 


Gln Asn His Gly Lys Leu Asn Gly Ile Lys Trp His Tyr Phe Lys Gly 
                245                 250                 255     


Pro Ser Tyr Ser Leu Arg Ser Thr Thr Met Met Ile Arg Pro Leu Asp 
            260                 265                 270         


Phe 
    


<210>  48
<211>  822
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence encoding IKC076V construct

<400>  48
atgcgccgcc tgctgatcct ggccctggtg ggcgccgccg tggccgagga ggccggccgc       60

gccctggccg ccgtgctgga ggagctgcgc cagacccgcg ccgacctgca cgccgtgcag      120

accaaggagg gcgtgctgct gaagggcggc aagcgcgagg aggagaagcc cttccgcgac      180

tgcgccgacg tgtaccaggc cggcttcaac aagagcggca tctacaccat ctacatcaac      240

aacatgcccg agcccaagaa ggtgttctgc aacatggacg tgaacggcgg cggctggacc      300

gtgatccagc accgcgagga cggcagcctg gacttccagc gcggctggaa ggagtacaag      360

atgggcttcg gcaaccccag cggcgagtac tggctgggca acgagttcat cttcgccatc      420

accagccagc gccagtacat gctgcgcatc gagctgatgg actgggaggg caaccgcgcc      480

tacagccagt acgaccgctt ccacatcggc aacgagaagc agaactaccg cctgtacctg      540

aagggccaca ccggcaccgc cggcaagcag agcagcctga tcctgcacgg cgccgacttc      600

agcaccaagg acgccgacaa cgacaactgc atgtgcaagt gcgccctgat gctgaccggc      660

ggctggtggt tcgacgcctg cggccccagc aacctgaacg gcatgttcta caccgccggc      720

cagaaccacg gcaagctgaa cggcatcaag tggcactact tcaagggccc cagctacagc      780

ctgcgcagca ccaccatgat gatccgcccc ctggacttct ga                         822


<210>  49
<211>  2199
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant vector (IKC074V)

<400>  49
cgcgctcgct cgctcactga ggccgcccgg gcaaagcccg ggcgtcgggc gacctttggt       60

cgcccggcct cagtgagcga gcgagcgcgc agagagggag tggtagtaat caattaccgg      120

tcattaggag ttccgcgtta cataacttac ggtaaatggc ccgcctggct gaccgcccaa      180

cgacccccgc ccattgacgt caataatgac gtatgttccc atagtaacgc caatagggac      240

tttccattga cgtcaatggg tggagtattt acggtaaact gcccacttgg cagtacatca      300

agtgtatcat atgccaagta cgccccctat tgacgtcaat gacggtaaat ggcccgcctg      360

gcattatgcc cagtacatga ccttatggga ctttcctact tggcagtaca tctacgtatt      420

agtcatcgct attaccatgg tgatgcggtt ttggcagtac atcaatgggc gtggatagcg      480

gtttgactca cggggatttc caagtctcca ccccattgac gtcaatggga gtttgttttg      540

gcaccaaaat caacgggact ttccaaaatg tcgtaacaac tccgccccat tgacgcaaat      600

gggcggtagg cgtgtacggt gggaggtcta tataagcaga gctcgtttgc tagcgccacc      660

atgcgccgcc tgctgatcct ggccctggtg ggcgccgccg tggcctgcgc cagcagcgcc      720

caggtgctgc aggagctgct gagccgcatc gagatgctgg agcgcgaggt gagcgtgctg      780

cgcgaccagt gcaacaccaa ggagggcgtg ctgctgaagg gcggcaagcg cgaggaggag      840

aagcccttcc gcgactgcgc cgacgtgtac caggccggct tcaacaagag cggcatctac      900

accatctaca tcaacaacat gcccgagccc aagaaggtgt tctgcaacat ggacgtgaac      960

ggcggcggct ggaccgtgat ccagcaccgc gaggacggca gcctggactt ccagcgcggc     1020

tggaaggagt acaagatggg cttcggcaac cccagcggcg agtactggct gggcaacgag     1080

ttcatcttcg ccatcaccag ccagcgccag tacatgctgc gcatcgagct gatggactgg     1140

gagggcaacc gcgcctacag ccagtacgac cgcttccaca tcggcaacga gaagcagaac     1200

taccgcctgt acctgaaggg ccacaccggc accgccggca agcagagcag cctgatcctg     1260

cacggcgccg acttcagcac caaggacgcc gacaacgaca actgcatgtg caagtgcgcc     1320

ctgatgctga ccggcggctg gtggttcgac gcctgcggcc ccagcaacct gaacggcatg     1380

ttctacaccg ccggccagaa ccacggcaag ctgaacggca tcaagtggca ctacttcaag     1440

ggccccagct acagcctgcg cagcaccacc atgatgatcc gccccctgga cttctgatat     1500

actactagta cgcggccgca ctggtgtaca atcaacctct ggattacaaa atttgtgaaa     1560

gattgactgg tattcttaac tatgttgctc cttttacgct atgtggatac gctgctttaa     1620

tgcctttgta tcatgctatt gcttcccgta tggctttcat tttctcctcc ttgtataaat     1680

cctggttagt tcttgccacg gcggaactca tcgccgcctg ccttgcccgc tgctggacag     1740

gggctcggct gttgggcact gacaattccg tggtgtgaat tcgaggatac cgtcgacagc     1800

agacatgata agatacattg atgagtttgg acaaaccaca actagaatgc agtgaaaaaa     1860

atgctttatt tgtgaaattt gtgatgctat tgctttattt gtaaccatta taagctgcaa     1920

taaacaagtt aacaacaaca attgcattca ttttatgttt caggttcagg gggaggtgtg     1980

ggaggttttt taaagcaagt aaaacctcta caaatgtggt atgggcatgg ctacgtagat     2040

aagtagcatg gcgggttaat cattaactac aaggaacccc tagtgatgga gttggccact     2100

ccctctctgc gcgctcgctc gctcactgag gccgggcgac caaaggtcgc ccgacgcccg     2160

ggctttgccc gggcggcctc agtgagcgag cgagcgcgc                            2199


