                               SEQUENCE LISTING

<110> MCMASTER UNIVERSITY
 
<120> BCMA T CELL-ANTIGEN COUPLERS AND USES THEREOF

<130> V818573WO

<150> 63/202,839
<151> 2021-06-25

<160> 76    

<170> PatentIn version 3.5

<210> 1
<211> 54
<212> DNA
<213> Mus sp.

<220>
<223> muIgG leader (secretion signal)

<400> 1
atggatttcc aggtccagat tttctccttc ctgctgattt ccgcaagcgt catt             54


<210> 2
<211> 18
<212> PRT
<213> Mus sp.

<220>
<223> muIgG leader (secretion signal)

<400> 2
Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile 
        


<210> 3
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Myc Tag

<400> 3
gaacagaaac tgattagcga agaagacctg                                        30


<210> 4
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> Myc Tag

<400> 4
Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210> 5
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Linker 1

<400> 5
actagtggcg gaggaggatc actcgag                                           27


<210> 6
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> Linker 1

<400> 6
Thr Ser Gly Gly Gly Gly Ser Leu Glu 
1               5                   


<210> 7
<211> 75
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Linker 2

<400> 7
aaccccgggg gaggaggagg gagcggggga ggaggcagcg gcgggggagg ctctggagga       60

ggagggagcg gatcc                                                        75


<210> 8
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> Linker 2

<400> 8
Asn Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser Gly Gly Gly Gly Ser Gly Ser 
            20                  25  


<210> 9
<211> 66
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> CD4 based linker

<400> 9
agcggacagg tgctgctgga atccaatatc aaagtcctgc ccacttggtc tacccccgtg       60

cagcct                                                                  66


<210> 10
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> CD4 based linker

<400> 10
Ser Gly Gln Val Leu Leu Glu Ser Asn Ile Lys Val Leu Pro Thr Trp 
1               5                   10                  15      


Ser Thr Pro Val Gln Pro 
            20          


<210> 11
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Short Helix connector

<400> 11
gccgaagcag cagcaaagga ggccgcagcg aaggaagcag ctgcgaaggc c                51


<210> 12
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> Short Helix connector

<400> 12
Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
1               5                   10                  15      


Ala 
    


<210> 13
<211> 81
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Long Helix connector

<400> 13
gccgaggcag ctgcaaagga agctgcggcg aaggaggccg cagcgaaaga agcagcggca       60

aaagaagcag ccgccaaagc c                                                 81


<210> 14
<211> 27
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> Long Helix connector

<400> 14
Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
1               5                   10                  15      


Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala 
            20                  25          


<210> 15
<211> 576
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> Large domain connector

<400> 15
atcgtagtgt tggcatttca aaaagcgtct agcatcgtct ataagaagga aggtgaacaa       60

gtcgagtttt ctttccccct tgcatttacg gtggaaaagc ttacgggtag cggcgagctg      120

tggtggcaag ctgaacgggc ttcaagctca aaatcttgga ttacttttga cttgaagaac      180

aaagaggtga gtgtcaaaag agttactcag gacccaaagc ttcaaatggg gaagaaactt      240

ccgctgcacc tgacgttgcc tcaggccctg cctcaatatg ccggctcagg caatctgacc      300

ctcgcgctgg aagctaagac cggaaaattg caccaggaag tcaatttggt tgtgatgcgc      360

gccactcagc tccaaaaaaa tctcacttgc gaggtatggg ggcctacgag cccaaaactt      420

atgctgtctt tgaagcttga aaacaaggaa gcgaaagttt ctaagcgcga gaaagcggta      480

tgggttttga atcctgaggc tggaatgtgg caatgcctcc tgagcgatag cgggcaggtg      540

ctgttggaga gcaacatcaa ggttttgcca gcagcc                                576


<210> 16
<211> 192
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> Large domain connector

<400> 16
Ile Val Val Leu Ala Phe Gln Lys Ala Ser Ser Ile Val Tyr Lys Lys 
1               5                   10                  15      


Glu Gly Glu Gln Val Glu Phe Ser Phe Pro Leu Ala Phe Thr Val Glu 
            20                  25                  30          


Lys Leu Thr Gly Ser Gly Glu Leu Trp Trp Gln Ala Glu Arg Ala Ser 
        35                  40                  45              


Ser Ser Lys Ser Trp Ile Thr Phe Asp Leu Lys Asn Lys Glu Val Ser 
    50                  55                  60                  


Val Lys Arg Val Thr Gln Asp Pro Lys Leu Gln Met Gly Lys Lys Leu 
65                  70                  75                  80  


Pro Leu His Leu Thr Leu Pro Gln Ala Leu Pro Gln Tyr Ala Gly Ser 
                85                  90                  95      


Gly Asn Leu Thr Leu Ala Leu Glu Ala Lys Thr Gly Lys Leu His Gln 
            100                 105                 110         


Glu Val Asn Leu Val Val Met Arg Ala Thr Gln Leu Gln Lys Asn Leu 
        115                 120                 125             


Thr Cys Glu Val Trp Gly Pro Thr Ser Pro Lys Leu Met Leu Ser Leu 
    130                 135                 140                 


Lys Leu Glu Asn Lys Glu Ala Lys Val Ser Lys Arg Glu Lys Ala Val 
145                 150                 155                 160 


Trp Val Leu Asn Pro Glu Ala Gly Met Trp Gln Cys Leu Leu Ser Asp 
                165                 170                 175     


Ser Gly Gln Val Leu Leu Glu Ser Asn Ile Lys Val Leu Pro Ala Ala 
            180                 185                 190         


<210> 17
<211> 60
<212> DNA
<213> Homo sapiens

<220>
<223> huIgG

<400> 17
atggagaccc ccgcccagct gctgttcctg ctgctgctgt ggctgcccga caccaccggc       60


<210> 18
<211> 20
<212> PRT
<213> Homo sapiens

<220>
<223> huIgG

<400> 18
Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly 
            20  


<210> 19
<211> 63
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> huCD8a (1162)

<400> 19
atggccctgc cagtgaccgc cctgctgctg ccactggccc tgctgctgca cgccgccaga       60

ccc                                                                     63


<210> 20
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> huCD8a (1162)

<400> 20
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210> 21
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Whitlow

<400> 21
ggatctacca gcggatccgg caagcctggc agcggagagg gatccacaaa ggga             54


<210> 22
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> Whitlow

<400> 22
Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr 
1               5                   10                  15      


Lys Gly 
        


<210> 23
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> (G4S)3 linker

<400> 23
ggcggcggcg gaagtggagg aggaggctca ggcggaggag ggagc                       45


<210> 24
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> (G4S)3 linker

<400> 24
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210> 25
<211> 60
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> (G4S)4-based linker

<400> 25
ggaggaggag ggagcggggg aggaggcagc ggcgggggag gctctggagg aggagggagc       60


<210> 26
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> (G4S)4-based linker

<400> 26
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210> 27
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> G4S-based linker

<400> 27
ggaggaggag ggagc                                                        15


<210> 28
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> G4S-based linker

<400> 28
Gly Gly Gly Gly Ser 
1               5   


<210> 29
<211> 63
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> huCD8a (1165)

<400> 29
atggccctgc cagtgaccgc cctgctgctg ccactggccc tgctgctgca cgccgcccgg       60

cct                                                                     63


<210> 30
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> huCD8a (1165)

<400> 30
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210> 31
<211> 750
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> UCHT11

<400> 31
atggacatcc agatgactca gaccacaagc tccctgtctg caagtctggg cgaccgggtg       60

acaatctcct gcagagcctc tcaggatatt aggaactacc tgaattggta tcagcagaaa      120

cctgatggca cagtcaagct gctgatctac tataccagcc ggctgcactc aggcgtgcca      180

agcaaattct caggaagcgg ctccgggact gactactccc tgaccatctc taacctggag      240

caggaagata ttgctaccta tttctgccag cagggcaata cactgccctg gacttttgcc      300

ggaggcacca aactggagat caagggggga ggcgggagtg gaggcggggg atcaggagga      360

ggaggcagcg gaggaggagg gtccgaggtc cagctgcagc agagcggacc agaactggtg      420

aagcccggag caagtatgaa aatctcctgt aaggcctcag gatacagctt caccggctat      480

acaatgaact gggtgaaaca gtcccatggc aagaacctgg aatggatggg gctgattaat      540

ccttacaaag gcgtcagcac ctataatcag aagtttaaag acaaggccac actgactgtg      600

gataagtcta gttcaaccgc ttacatggag ctgctgtccc tgacatctga agacagtgcc      660

gtgtactatt gtgctcggtc tggctactat ggggacagtg attggtactt cgatgtctgg      720

ggacagggca ctaccctgac cgtgttttct                                       750


<210> 32
<211> 250
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> UCHT12

<400> 32
Met Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu 
1               5                   10                  15      


Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Arg Asn 
            20                  25                  30          


Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Lys Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu 
65                  70                  75                  80  


Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro 
                85                  90                  95      


Trp Thr Phe Ala Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
    130                 135                 140                 


Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
145                 150                 155                 160 


Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu Glu Trp Met 
                165                 170                 175     


Gly Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Asn Gln Lys Phe 
            180                 185                 190         


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
        195                 200                 205             


Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
    210                 215                 220                 


Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp 
225                 230                 235                 240 


Gly Gln Gly Thr Thr Leu Thr Val Phe Ser 
                245                 250 


<210> 33
<211> 769
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> OKT3

<400> 33
atggccgaca tcgtgctgac acagagcccc gccatcatgt ctgccagccc tggcgagaaa       60

gtgaccatga cctgtagcgc cagcagcagc gtgtcctaca tgaactggta tcagcagaag      120

tccggcacca gccccaagcg gtggatctac gacacaagca agctggcctc tggcgtgccc      180

gcccacttta gaggctctgg cagcggcaca agctacagcc tgaccatcag cggcatggaa      240

gccgaggatg ccgccaccta ctactgccag cagtggtcca gcaacccctt cacctttggc      300

tccggcacaa agctggaaat caaccgggcc gacaccgccc ctacaggcgg cggaggatct      360

ggcggaggcg gatctggggg cggaggaagt ggggggggag gatctatggc tcaggtgcag      420

ctgcagcagt ctggcgccga actggctaga cctggcgcct ccgtgaagat gagctgcaag      480

gccagcggct acaccttcac ccggtacacc atgcactggg tcaagcagag gcctggacag      540

ggcctggaat ggatcggcta catcaacccc agccggggct acaccaacta caaccagaag      600

ttcaaggaca aggccaccct gaccaccgac aagagcagca gcaccgccta catgcagctg      660

tcctccctga ccagcgagga cagcgccgtg tactactgcg cccggtacta cgacgaccac      720

tactccctgg actactgggg ccagggcacc acactgaccg tgtctagta                  769


<210> 34
<211> 256
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> OKT3

<400> 34
Met Ala Asp Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser 
1               5                   10                  15      


Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser 
            20                  25                  30          


Tyr Met Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp 
        35                  40                  45              


Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala His Phe Arg 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Gly Met Glu 
65                  70                  75                  80  


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro 
                85                  90                  95      


Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Asn Arg Ala Asp Thr 
            100                 105                 110         


Ala Pro Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Met Ala Gln Val Gln Leu Gln Gln Ser 
    130                 135                 140                 


Gly Ala Glu Leu Ala Arg Pro Gly Ala Ser Val Lys Met Ser Cys Lys 
145                 150                 155                 160 


Ala Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Lys Gln 
                165                 170                 175     


Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg 
            180                 185                 190         


Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr 
        195                 200                 205             


Thr Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr 
    210                 215                 220                 


Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His 
225                 230                 235                 240 


Tyr Ser Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
                245                 250                 255     


<210> 35
<211> 747
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> F6A

<400> 35
cagaccgtgg tgacccagga gcccagcctg accgtgagcc ccggcggcac cgtgaccctg       60

acctgcggca gcagcaccgg cgccgtgacc agcggctact accccaactg ggtgcagcag      120

aagcccggcc aggcccccag gggcctgatc ggcggcacca agttcctggc ccccggcacc      180

cccgccaggt tcagcggcag cctgctgggc ggcaaggccg ccctgaccct gagcggcgtg      240

cagcccgagg acgaggccga gtactactgc gccctgtggt acagcaacag gtgggtgttc      300

ggcggcggca ccaagctgac cgtgctgggc ggcggcggca gcggcggcgg cggcagcggc      360

ggcggcggca gcgaggtgca gctgctggag agcggcggcg gcctggtgca gcccggcggc      420

agcctgaagc tgagctgcgc cgccagcggc ttcaccttca acatctacgc catgaactgg      480

gtgaggcagg cccccggcaa gggcctggag tgggtggcca ggatcaggag caagtacaac      540

aactacgcca cctactacgc cgacagcgtg aagagcaggt tcaccatcag cagggacgac      600

agcaagaaca ccgcctacct gcagatgaac aacctgaaga ccgaggacac cgccgtgtac      660

tactgcgtga ggcacggcaa cttcggcaac agctacgtga gcttcttcgc ctactggggc      720

cagggcaccc tggtgaccgt gagcagc                                          747


<210> 36
<211> 249
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> F6A

<400> 36
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 
        115                 120                 125             


Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu 
    130                 135                 140                 


Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ile Tyr Ala Met Asn Trp 
145                 150                 155                 160 


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg 
                165                 170                 175     


Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Ser 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln 
        195                 200                 205             


Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg 
    210                 215                 220                 


His Gly Asn Phe Gly Asn Ser Tyr Val Ser Phe Phe Ala Tyr Trp Gly 
225                 230                 235                 240 


Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 


<210> 37
<211> 720
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> L2K

<400> 37
gacatccagc tgacccagag ccccgccatc atgagcgcca gccccggcga gaaggtgacc       60

atgacctgca gggccagcag cagcgtgagc tacatgaact ggtaccagca gaagagcggc      120

accagcccca agaggtggat ctacgacacc agcaaggtgg ccagcggcgt gccctacagg      180

ttcagcggca gcggcagcgg caccagctac agcctgacca tcagcagcat ggaggccgag      240

gacgccgcca cctactactg ccagcagtgg agcagcaacc ccctgacctt cggcgccggc      300

accaagctgg agctgaaggg cggcggcggc agcggcggcg gcggcagcgg cggcggcggc      360

agcgacatca agctgcagca gagcggcgcc gagctggcca ggcccggcgc cagcgtgaag      420

atgagctgca agaccagcgg ctacaccttc accaggtaca ccatgcactg ggtgaagcag      480

aggcccggcc agggcctgga gtggatcggc tacatcaacc ccagcagggg ctacaccaac      540

tacaaccaga agttcaagga caaggccacc ctgaccaccg acaagagcag cagcaccgcc      600

tacatgcagc tgagcagcct gaccagcgag gacagcgccg tgtactactg cgccaggtac      660

tacgacgacc actactgcct ggactactgg ggccagggca ccaccctgac cgtgagcagc      720


<210> 38
<211> 240
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> L2K

<400> 38
Asp Ile Gln Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Val Ala Ser Gly Val Pro Tyr Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Gly Gly Gly Gly Ser Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Lys Leu Gln Gln Ser 
        115                 120                 125             


Gly Ala Glu Leu Ala Arg Pro Gly Ala Ser Val Lys Met Ser Cys Lys 
    130                 135                 140                 


Thr Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Lys Gln 
145                 150                 155                 160 


Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg 
                165                 170                 175     


Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr 
            180                 185                 190         


Thr Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr 
        195                 200                 205             


Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His 
    210                 215                 220                 


Tyr Cys Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
225                 230                 235                 240 


<210> 39
<211> 735
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> huUCHT1

<400> 39
atggatatcc agatgaccca gtccccgagc tccctgtccg cctctgtggg cgatagggtc       60

accatcacct gccgtgccag tcaggacatc cgtaattatc tgaactggta tcaacagaaa      120

ccaggaaaag ctccgaaact actgatttac tatacctccc gcctggagtc tggagtccct      180

tctcgcttct ctggttctgg ttctgggacg gattacactc tgaccatcag cagtctgcaa      240

ccggaagact tcgcaactta ttactgtcag caaggtaata ctctgccgtg gacgttcgga      300

cagggcacca aggtggagat caaaggcggc ggcggaagtg gaggaggagg ctcaggcgga      360

ggagggagcg aggttcagct ggtggagtct ggcggtggcc tggtgcagcc agggggctca      420

ctccgtttgt cctgtgcagc ttctggctac tcctttaccg gctacactat gaactgggtg      480

cgtcaggccc caggtaaggg cctggaatgg gttgcactga ttaatcctta taaaggtgtt      540

agtacctaca accagaagtt caaggaccgt ttcactataa gcgtagataa atccaaaaac      600

acagcctacc tgcaaatgaa cagcctgcgt gctgaggaca ctgccgtcta ttattgtgct      660

agaagcggat actacggcga tagtgactgg tattttgacg tgtggggtca aggaaccctg      720

gtcaccgtct cctcg                                                       735


<210> 40
<211> 245
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> huUCHT1

<400> 40
Met Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val 
1               5                   10                  15      


Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn 
            20                  25                  30          


Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Thr Ser Arg Leu Glu Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
        115                 120                 125             


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
    130                 135                 140                 


Cys Ala Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Thr Met Asn Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Leu Ile Asn Pro 
                165                 170                 175     


Tyr Lys Gly Val Ser Thr Tyr Asn Gln Lys Phe Lys Asp Arg Phe Thr 
            180                 185                 190         


Ile Ser Val Asp Lys Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser 
        195                 200                 205             


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Gly Tyr 
    210                 215                 220                 


Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr Leu 
225                 230                 235                 240 


Val Thr Val Ser Ser 
                245 


<210> 41
<211> 735
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> huUCHT1 (Y177T)

<400> 41
atggatatcc agatgaccca gtccccgagc tccctgtccg cctctgtggg cgatagggtc       60

accatcacct gccgtgccag tcaggacatc cgtaattatc tgaactggta tcaacagaaa      120

ccaggaaaag ctccgaaact actgatttac tatacctccc gcctggagtc tggagtccct      180

tctcgcttct ctggttctgg ttctgggacg gattacactc tgaccatcag cagtctgcaa      240

ccggaagact tcgcaactta ttactgtcag caaggtaata ctctgccgtg gacgttcgga      300

cagggcacca aggtggagat caaaggcggc ggcggaagtg gaggaggagg ctcaggcgga      360

ggagggagcg aggttcagct ggtggagtct ggcggtggcc tggtgcagcc agggggctca      420

ctccgtttgt cctgtgcagc ttctggctac tcctttaccg gctacactat gaactgggtg      480

cgtcaggccc caggtaaggg cctggaatgg gttgcactga ttaatcctac caaaggtgtt      540

agtacctaca accagaagtt caaggaccgt ttcactataa gcgtagataa atccaaaaac      600

acagcctacc tgcaaatgaa cagcctgcgt gctgaggaca ctgccgtcta ttattgtgct      660

agaagcggat actacggcga tagtgactgg tattttgacg tgtggggtca aggaaccctg      720

gtcaccgtct cctcg                                                       735


<210> 42
<211> 245
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> huUCHT1 (Y177T)

<400> 42
Met Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val 
1               5                   10                  15      


Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn 
            20                  25                  30          


Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Thr Ser Arg Leu Glu Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
        115                 120                 125             


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
    130                 135                 140                 


Cys Ala Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Thr Met Asn Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Leu Ile Asn Pro 
                165                 170                 175     


Thr Lys Gly Val Ser Thr Tyr Asn Gln Lys Phe Lys Asp Arg Phe Thr 
            180                 185                 190         


Ile Ser Val Asp Lys Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser 
        195                 200                 205             


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Gly Tyr 
    210                 215                 220                 


Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr Leu 
225                 230                 235                 240 


Val Thr Val Ser Ser 
                245 


<210> 43
<211> 750
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> UCHT1 (Y182T)

<400> 43
atggacatcc agatgactca gaccacaagc tccctgtctg caagtctggg cgaccgggtg       60

acaatctcct gcagagcctc tcaggatatt aggaactacc tgaattggta tcagcagaaa      120

cctgatggca cagtcaagct gctgatctac tataccagcc ggctgcactc aggcgtgcca      180

agcaaattct caggaagcgg ctccgggact gactactccc tgaccatctc taacctggag      240

caggaagata ttgctaccta tttctgccag cagggcaata cactgccctg gacttttgcc      300

ggaggcacca aactggagat caagggggga ggcgggagtg gaggcggggg atcaggagga      360

ggaggcagcg gaggaggagg gtccgaggtc cagctgcagc agagcggacc agaactggtg      420

aagcccggag caagtatgaa aatctcctgt aaggcctcag gatacagctt caccggctat      480

acaatgaact gggtgaaaca gtcccatggc aagaacctgg aatggatggg gctgattaat      540

cctaccaaag gcgtcagcac ctataatcag aagtttaaag acaaggccac actgactgtg      600

gataagtcta gttcaaccgc ttacatggag ctgctgtccc tgacatctga agacagtgcc      660

gtgtactatt gtgctcggtc tggctactat ggggacagtg attggtactt cgatgtctgg      720

ggacagggca ctaccctgac cgtgttttct                                       750


<210> 44
<211> 250
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> UCHT1 (Y182T)

<400> 44
Met Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu 
1               5                   10                  15      


Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Arg Asn 
            20                  25                  30          


Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Lys Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu 
65                  70                  75                  80  


Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro 
                85                  90                  95      


Trp Thr Phe Ala Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
    130                 135                 140                 


Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
145                 150                 155                 160 


Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu Glu Trp Met 
                165                 170                 175     


Gly Leu Ile Asn Pro Thr Lys Gly Val Ser Thr Tyr Asn Gln Lys Phe 
            180                 185                 190         


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
        195                 200                 205             


Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
    210                 215                 220                 


Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp 
225                 230                 235                 240 


Gly Gln Gly Thr Thr Leu Thr Val Phe Ser 
                245                 250 


<210> 45
<211> 252
<212> DNA
<213> Homo sapiens

<220>
<223> CD4 Domain1

<400> 45
agcggacagg tgctgctgga atccaatatc aaagtcctgc ccacttggtc tacccccgtg       60

cagcctatgg ctctgattgt gctgggagga gtcgcaggac tgctgctgtt tatcgggctg      120

ggaattttct tttgcgtgcg ctgccggcac cggagaaggc aggccgagcg catgagccag      180

atcaagcgac tgctgagcga gaagaaaacc tgtcagtgtc cccatagatt ccagaagacc      240

tgttcaccca tt                                                          252


<210> 46
<211> 84
<212> PRT
<213> Homo sapiens

<220>
<223> CD4 Domain2

<400> 46
Ser Gly Gln Val Leu Leu Glu Ser Asn Ile Lys Val Leu Pro Thr Trp 
1               5                   10                  15      


Ser Thr Pro Val Gln Pro Met Ala Leu Ile Val Leu Gly Gly Val Ala 
            20                  25                  30          


Gly Leu Leu Leu Phe Ile Gly Leu Gly Ile Phe Phe Cys Val Arg Cys 
        35                  40                  45              


Arg His Arg Arg Arg Gln Ala Glu Arg Met Ser Gln Ile Lys Arg Leu 
    50                  55                  60                  


Leu Ser Glu Lys Lys Thr Cys Gln Cys Pro His Arg Phe Gln Lys Thr 
65                  70                  75                  80  


Cys Ser Pro Ile 
                


<210> 47
<211> 237
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> CD8alpha Domain

<400> 47
ctcgagctga ggcccgaggc ttctagacct gctgccggcg gagccgtgca caccagaggc       60

ctggacttcg ccagcgacat ctacatctgg gcccctctgg ccggcacctg tggcgtgctg      120

ctgctgagcc tggtcatcac cctgtactgc aaccaccgga accggcggag agtgtgcaag      180

tgccccagac ccgtggtcaa gagcggcgac aagcccagcc tgagcgccag atacgtg         237


<210> 48
<211> 79
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> CD8alpha Domain

<400> 48
Leu Glu Leu Arg Pro Glu Ala Ser Arg Pro Ala Ala Gly Gly Ala Val 
1               5                   10                  15      


His Thr Arg Gly Leu Asp Phe Ala Ser Asp Ile Tyr Ile Trp Ala Pro 
            20                  25                  30          


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
        35                  40                  45              


Tyr Cys Asn His Arg Asn Arg Arg Arg Val Cys Lys Cys Pro Arg Pro 
    50                  55                  60                  


Val Val Lys Ser Gly Asp Lys Pro Ser Leu Ser Ala Arg Tyr Val 
65                  70                  75                  


<210> 49
<211> 234
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> CD8alpha+R(beta) Domain

<400> 49
ctcgagctga ggcccgaggc ttctagacct gctgccggcg gagccgtgca caccagaggc       60

ctggacttcg ccagcgacat ctacatctgg gcccctctgg ccggcacctg tggcgtgctg      120

ctgctgagcc tggtcatcac cctgtacctg tgctgcagac ggcggagagt gtgcaagtgc      180

cccagacccg tggtcaagag cggcgacaag cccagcctga gcgccagata cgtg            234


<210> 50
<211> 78
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> CD8alpha+R(beta) Domain

<400> 50
Leu Glu Leu Arg Pro Glu Ala Ser Arg Pro Ala Ala Gly Gly Ala Val 
1               5                   10                  15      


His Thr Arg Gly Leu Asp Phe Ala Ser Asp Ile Tyr Ile Trp Ala Pro 
            20                  25                  30          


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
        35                  40                  45              


Tyr Leu Cys Cys Arg Arg Arg Arg Val Cys Lys Cys Pro Arg Pro Val 
    50                  55                  60                  


Val Lys Ser Gly Asp Lys Pro Ser Leu Ser Ala Arg Tyr Val 
65                  70                  75              


<210> 51
<211> 213
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> CD8 alpha +Lck Domain

<400> 51
ctcgagaaga agtccaccct gaagaaacgg gtgtcccggc tgcccagacc cgagacacag       60

aagggccccc tgagcagccc tatcaccctg ggactgctgg tggccggcgt gctggtgctg      120

ctggtgtctc tgggagtggc catccacctg tgctgccggc ggagaagggc ctgcaagtgc      180

cccagactgc ggttcatgaa gcagttctac aag                                   213


<210> 52
<211> 71
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> CD8 alpha +Lck Domain

<400> 52
Leu Glu Lys Lys Ser Thr Leu Lys Lys Arg Val Ser Arg Leu Pro Arg 
1               5                   10                  15      


Pro Glu Thr Gln Lys Gly Pro Leu Ser Ser Pro Ile Thr Leu Gly Leu 
            20                  25                  30          


Leu Val Ala Gly Val Leu Val Leu Leu Val Ser Leu Gly Val Ala Ile 
        35                  40                  45              


His Leu Cys Cys Arg Arg Arg Arg Ala Cys Lys Cys Pro Arg Leu Arg 
    50                  55                  60                  


Phe Met Lys Gln Phe Tyr Lys 
65                  70      


<210> 53
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> 3625 VL - CDR1

<400> 53
Ser Val Ser Ser Ala 
1               5   


<210> 54
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> 3625 VL - CDR2

<400> 54
Ser Ala Ser Ser Leu Tyr Ser 
1               5           


<210> 55
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> 3625 VL - CDR3

<400> 55
Ser Val Trp Val Gly Tyr Ser Leu Ile 
1               5                   


<210> 56
<211> 110
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> 3625 VL

<400> 56
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Val Trp Val Gly Tyr 
                85                  90                  95      


Ser Leu Ile Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110 


<210> 57
<211> 330
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> 3625 VL

<400> 57
gacatccaga tgacacagtc cccatccagc ctcagcgctt ccgtgggaga cagagtgacc       60

atcacatgca gggcaagcca gtccgtgtct agcgccgtgg catggtacca gcagaagccc      120

ggcaaggccc ctaagctgct gatctacagc gcctcctctc tgtattccgg cgtgccatct      180

cggttctctg gcagcagatc cggcaccgac tttaccctga caatcagctc cctgcagccc      240

gaggatttcg ccacatacta ttgccagcag agcgtgtggg tgggctactc cctgatcacc      300

tttggccagg gcacaaaagt cgaaattaag                                       330


<210> 58
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> 3625 VH - CDR1

<400> 58
Ile Tyr Tyr Ser Tyr Met 
1               5       


<210> 59
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> 3625 VH - CDR2

<400> 59
Ser Ile Ser Pro Tyr Tyr Gly Tyr Thr Ser 
1               5                   10  


<210> 60
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> 3625 VH - CDR3

<400> 60
His Gly Tyr Ala Leu 
1               5   


<210> 61
<211> 116
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> 3625 VH

<400> 61
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Tyr Tyr Ser 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Pro Tyr Tyr Gly Tyr Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Gly Tyr Ala Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210> 62
<211> 348
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> 3625 VH

<400> 62
gaggtgcagc tcgtggaaag cggcggaggg ctggtccagc caggcggctc tctgaggctg       60

agctgtgcag catccggctt caacatctac tatagctaca tgcattgggt ccgccaggct      120

cctggcaaag gactggaatg ggtggcctct atcagccctt actatggcta cacctcttat      180

gccgacagcg tgaagggccg gtttacaatc tccgccgata cctctaagaa cacagcctat      240

ctgcagatga attccctgag ggcagaggac accgccgtgt actattgtgc cagacacggc      300

tacgccctgg attattgggg ccagggcacc ctggtgacag tgtctagc                   348


<210> 63
<211> 244
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> 3625 scFv (VL-VH)

<400> 63
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Val Trp Val Gly Tyr 
                85                  90                  95      


Ser Leu Ile Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Ser 
            100                 105                 110         


Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly 
        115                 120                 125             


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
    130                 135                 140                 


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Tyr Tyr Ser 
145                 150                 155                 160 


Tyr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                165                 170                 175     


Ala Ser Ile Ser Pro Tyr Tyr Gly Tyr Thr Ser Tyr Ala Asp Ser Val 
            180                 185                 190         


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
        195                 200                 205             


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
    210                 215                 220                 


Ala Arg His Gly Tyr Ala Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val 
225                 230                 235                 240 


Thr Val Ser Ser 
                


<210> 64
<211> 732
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> 3625 scFv (VL-VH)

<400> 64
gacatccaga tgacacagtc cccatccagc ctcagcgctt ccgtgggaga cagagtgacc       60

atcacatgca gggcaagcca gtccgtgtct agcgccgtgg catggtacca gcagaagccc      120

ggcaaggccc ctaagctgct gatctacagc gcctcctctc tgtattccgg cgtgccatct      180

cggttctctg gcagcagatc cggcaccgac tttaccctga caatcagctc cctgcagccc      240

gaggatttcg ccacatacta ttgccagcag agcgtgtggg tgggctactc cctgatcacc      300

tttggccagg gcacaaaagt cgaaattaag ggatctacca gcggatccgg caagcctggc      360

agcggagagg gatccacaaa gggagaggtg cagctcgtgg aaagcggcgg agggctggtc      420

cagccaggcg gctctctgag gctgagctgt gcagcatccg gcttcaacat ctactatagc      480

tacatgcatt gggtccgcca ggctcctggc aaaggactgg aatgggtggc ctctatcagc      540

ccttactatg gctacacctc ttatgccgac agcgtgaagg gccggtttac aatctccgcc      600

gatacctcta agaacacagc ctatctgcag atgaattccc tgagggcaga ggacaccgcc      660

gtgtactatt gtgccagaca cggctacgcc ctggattatt ggggccaggg caccctggtg      720

acagtgtcta gc                                                          732


<210> 65
<211> 244
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> 3625 scFv (VH-VL)

<400> 65
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Tyr Tyr Ser 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Pro Tyr Tyr Gly Tyr Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Gly Tyr Ala Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly 
        115                 120                 125             


Glu Gly Ser Thr Lys Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
    130                 135                 140                 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
145                 150                 155                 160 


Gln Ser Val Ser Ser Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
                165                 170                 175     


Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val 
            180                 185                 190         


Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Ser Val Trp Val Gly Tyr Ser Leu Ile Thr Phe Gly Gln Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys 
                


<210> 66
<211> 732
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> 3625 scFv (VH-VL)

<400> 66
gaggtgcagc tggtggagtc tggaggaggc ctggtgcagc ctggcggctc cctgaggctg       60

tcttgcgcag caagcggctt caacatctac tatagctaca tgcactgggt gcgccaggcc      120

cctggcaagg gcctggagtg ggtggcctcc atctctccat actatggcta cacctcctat      180

gccgactctg tgaagggccg gtttacaatc agcgccgata cctccaagaa cacagcctat      240

ctgcagatga attccctgag ggcagaggac accgccgtgt actattgcgc cagacacggc      300

tacgccctgg attattgggg ccagggcacc ctggtgacag tgagctccgg cagcacatcc      360

ggatctggca agccaggctc tggagaggga agcaccaagg gcgacatcca gatgacacag      420

tccccatcta gcctgagcgc ctccgtgggc gatagggtga ccatcacatg tcgcgcctct      480

cagagcgtgt cctctgccgt ggcatggtac cagcagaagc ccggcaaggc ccctaagctg      540

ctgatctaca gcgccagctc cctgtattcc ggcgtgcctt ctcggttctc cggctctaga      600

agcggcaccg actttaccct gacaatctct agcctgcagc ccgaggattt cgccacatac      660

tattgtcagc agagcgtgtg ggtgggctac tccctgatca cctttggcca gggcacaaag      720

gtggagatca ag                                                          732


<210> 67
<211> 617
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> 1165 TAC (w/o leader sequence)

<400> 67
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Val Trp Val Gly Tyr 
                85                  90                  95      


Ser Leu Ile Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Ser 
            100                 105                 110         


Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly 
        115                 120                 125             


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
    130                 135                 140                 


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Tyr Tyr Ser 
145                 150                 155                 160 


Tyr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                165                 170                 175     


Ala Ser Ile Ser Pro Tyr Tyr Gly Tyr Thr Ser Tyr Ala Asp Ser Val 
            180                 185                 190         


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
        195                 200                 205             


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
    210                 215                 220                 


Ala Arg His Gly Tyr Ala Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val 
225                 230                 235                 240 


Thr Val Ser Ser Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Pro 
                245                 250                 255     


Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Gly Ser Met Asp Ile Gln Met Thr Gln Ser Pro 
        275                 280                 285             


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
    290                 295                 300                 


Ala Ser Gln Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
305                 310                 315                 320 


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu Glu Ser 
                325                 330                 335     


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 
            340                 345                 350         


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
        355                 360                 365             


Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val 
    370                 375                 380                 


Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
385                 390                 395                 400 


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
                405                 410                 415     


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Phe Thr 
            420                 425                 430         


Gly Tyr Thr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
        435                 440                 445             


Trp Val Ala Leu Ile Asn Pro Thr Lys Gly Val Ser Thr Tyr Asn Gln 
    450                 455                 460                 


Lys Phe Lys Asp Arg Phe Thr Ile Ser Val Asp Lys Ser Lys Asn Thr 
465                 470                 475                 480 


Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                485                 490                 495     


Tyr Cys Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp 
            500                 505                 510         


Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Ser Gly Gly 
        515                 520                 525             


Gly Gly Ser Leu Glu Ser Gly Gln Val Leu Leu Glu Ser Asn Ile Lys 
    530                 535                 540                 


Val Leu Pro Thr Trp Ser Thr Pro Val Gln Pro Met Ala Leu Ile Val 
545                 550                 555                 560 


Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile Gly Leu Gly Ile Phe 
                565                 570                 575     


Phe Cys Val Arg Cys Arg His Arg Arg Arg Gln Ala Glu Arg Met Ser 
            580                 585                 590         


Gln Ile Lys Arg Leu Leu Ser Glu Lys Lys Thr Cys Gln Cys Pro His 
        595                 600                 605             


Arg Phe Gln Lys Thr Cys Ser Pro Ile 
    610                 615         


<210> 68
<211> 1854
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> 1165 TAC (w/o leader sequence)

<400> 68
gacatccaga tgacacagtc cccatccagc ctcagcgctt ccgtgggaga cagagtgacc       60

atcacatgca gggcaagcca gtccgtgtct agcgccgtgg catggtacca gcagaagccc      120

ggcaaggccc ctaagctgct gatctacagc gcctcctctc tgtattccgg cgtgccatct      180

cggttctctg gcagcagatc cggcaccgac tttaccctga caatcagctc cctgcagccc      240

gaggatttcg ccacatacta ttgccagcag agcgtgtggg tgggctactc cctgatcacc      300

tttggccagg gcacaaaagt cgaaattaag ggatctacca gcggatccgg caagcctggc      360

agcggagagg gatccacaaa gggagaggtg cagctcgtgg aaagcggcgg agggctggtc      420

cagccaggcg gctctctgag gctgagctgt gcagcatccg gcttcaacat ctactatagc      480

tacatgcatt gggtccgcca ggctcctggc aaaggactgg aatgggtggc ctctatcagc      540

ccttactatg gctacacctc ttatgccgac agcgtgaagg gccggtttac aatctccgcc      600

gatacctcta agaacacagc ctatctgcag atgaattccc tgagggcaga ggacaccgcc      660

gtgtactatt gtgccagaca cggctacgcc ctggattatt ggggccaggg caccctggtg      720

acagtgtcta gcgagcagaa gctgatcagc gaggaggacc tgaatcccgg gggaggagga      780

gggagcgggg gaggaggcag cggcggggga ggctctggag gaggagggag cggatccatg      840

gatatccaga tgacccagtc cccgagctcc ctgtccgcct ctgtgggcga tagggtcacc      900

atcacctgcc gtgccagtca ggacatccgt aattatctga actggtatca acagaaacca      960

ggaaaagctc cgaaactact gatttactat acctcccgcc tggagtctgg agtcccttct     1020

cgcttctctg gttctggttc tgggacggat tacactctga ccatcagcag tctgcaaccg     1080

gaagacttcg caacttatta ctgtcagcaa ggtaatactc tgccgtggac gttcggacag     1140

ggcaccaagg tggagatcaa aggcggcggc ggaagtggag gaggaggctc aggcggagga     1200

gggagcgagg ttcagctggt ggagtctggc ggtggcctgg tgcagccagg gggctcactc     1260

cgtttgtcct gtgcagcttc tggctactcc tttaccggct acactatgaa ctgggtgcgt     1320

caggccccag gtaagggcct ggaatgggtt gcactgatta atcctaccaa aggtgttagt     1380

acctacaacc agaagttcaa ggaccgtttc actataagcg tagataaatc caaaaacaca     1440

gcctacctgc aaatgaacag cctgcgtgct gaggacactg ccgtctatta ttgtgctaga     1500

agcggatact acggcgatag tgactggtat tttgacgtgt ggggtcaagg aaccctggtc     1560

accgtctcct cgactagtgg cggaggagga tcactcgaga gcggacaggt gctgctggaa     1620

tccaatatca aagtcctgcc cacttggtct acccccgtgc agcctatggc tctgattgtg     1680

ctgggaggag tcgcaggact gctgctgttt atcgggctgg gaattttctt ttgcgtgcgc     1740

tgccggcacc ggagaaggca ggccgagcgc atgagccaga tcaagcgact gctgagcgag     1800

aagaaaacct gtcagtgtcc ccatagattc cagaagacct gttcacccat ttga           1854


<210> 69
<211> 638
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> 1165 TAC (w/ leader sequence)

<400> 69
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln 
        35                  40                  45              


Ser Val Ser Ser Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
    50                  55                  60                  


Pro Lys Leu Leu Ile Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser 
            100                 105                 110         


Val Trp Val Gly Tyr Ser Leu Ile Thr Phe Gly Gln Gly Thr Lys Val 
        115                 120                 125             


Glu Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu 
    130                 135                 140                 


Gly Ser Thr Lys Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Asn Ile Tyr Tyr Ser Tyr Met His Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ala Ser Ile Ser Pro Tyr Tyr Gly Tyr Thr Ser 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg His Gly Tyr Ala Leu Asp Tyr Trp Gly 
                245                 250                 255     


Gln Gly Thr Leu Val Thr Val Ser Ser Glu Gln Lys Leu Ile Ser Glu 
            260                 265                 270         


Glu Asp Leu Asn Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Ser Met Asp Ile Gln 
    290                 295                 300                 


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
305                 310                 315                 320 


Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr Leu Asn Trp 
                325                 330                 335     


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr 
            340                 345                 350         


Ser Arg Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
        355                 360                 365             


Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
    370                 375                 380                 


Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe Gly 
385                 390                 395                 400 


Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly 
                405                 410                 415     


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
            420                 425                 430         


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
        435                 440                 445             


Gly Tyr Ser Phe Thr Gly Tyr Thr Met Asn Trp Val Arg Gln Ala Pro 
    450                 455                 460                 


Gly Lys Gly Leu Glu Trp Val Ala Leu Ile Asn Pro Thr Lys Gly Val 
465                 470                 475                 480 


Ser Thr Tyr Asn Gln Lys Phe Lys Asp Arg Phe Thr Ile Ser Val Asp 
                485                 490                 495     


Lys Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
            500                 505                 510         


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Gly Tyr Tyr Gly Asp Ser 
        515                 520                 525             


Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
    530                 535                 540                 


Ser Thr Ser Gly Gly Gly Gly Ser Leu Glu Ser Gly Gln Val Leu Leu 
545                 550                 555                 560 


Glu Ser Asn Ile Lys Val Leu Pro Thr Trp Ser Thr Pro Val Gln Pro 
                565                 570                 575     


Met Ala Leu Ile Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile 
            580                 585                 590         


Gly Leu Gly Ile Phe Phe Cys Val Arg Cys Arg His Arg Arg Arg Gln 
        595                 600                 605             


Ala Glu Arg Met Ser Gln Ile Lys Arg Leu Leu Ser Glu Lys Lys Thr 
    610                 615                 620                 


Cys Gln Cys Pro His Arg Phe Gln Lys Thr Cys Ser Pro Ile 
625                 630                 635             


<210> 70
<211> 1917
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> 1165 TAC (w/ leader sequence)

<400> 70
atggccctgc cagtgaccgc cctgctgctg ccactggccc tgctgctgca cgccgcccgg       60

cctgacatcc agatgacaca gtccccatcc agcctcagcg cttccgtggg agacagagtg      120

accatcacat gcagggcaag ccagtccgtg tctagcgccg tggcatggta ccagcagaag      180

cccggcaagg cccctaagct gctgatctac agcgcctcct ctctgtattc cggcgtgcca      240

tctcggttct ctggcagcag atccggcacc gactttaccc tgacaatcag ctccctgcag      300

cccgaggatt tcgccacata ctattgccag cagagcgtgt gggtgggcta ctccctgatc      360

acctttggcc agggcacaaa agtcgaaatt aagggatcta ccagcggatc cggcaagcct      420

ggcagcggag agggatccac aaagggagag gtgcagctcg tggaaagcgg cggagggctg      480

gtccagccag gcggctctct gaggctgagc tgtgcagcat ccggcttcaa catctactat      540

agctacatgc attgggtccg ccaggctcct ggcaaaggac tggaatgggt ggcctctatc      600

agcccttact atggctacac ctcttatgcc gacagcgtga agggccggtt tacaatctcc      660

gccgatacct ctaagaacac agcctatctg cagatgaatt ccctgagggc agaggacacc      720

gccgtgtact attgtgccag acacggctac gccctggatt attggggcca gggcaccctg      780

gtgacagtgt ctagcgagca gaagctgatc agcgaggagg acctgaatcc cgggggagga      840

ggagggagcg ggggaggagg cagcggcggg ggaggctctg gaggaggagg gagcggatcc      900

atggatatcc agatgaccca gtccccgagc tccctgtccg cctctgtggg cgatagggtc      960

accatcacct gccgtgccag tcaggacatc cgtaattatc tgaactggta tcaacagaaa     1020

ccaggaaaag ctccgaaact actgatttac tatacctccc gcctggagtc tggagtccct     1080

tctcgcttct ctggttctgg ttctgggacg gattacactc tgaccatcag cagtctgcaa     1140

ccggaagact tcgcaactta ttactgtcag caaggtaata ctctgccgtg gacgttcgga     1200

cagggcacca aggtggagat caaaggcggc ggcggaagtg gaggaggagg ctcaggcgga     1260

ggagggagcg aggttcagct ggtggagtct ggcggtggcc tggtgcagcc agggggctca     1320

ctccgtttgt cctgtgcagc ttctggctac tcctttaccg gctacactat gaactgggtg     1380

cgtcaggccc caggtaaggg cctggaatgg gttgcactga ttaatcctac caaaggtgtt     1440

agtacctaca accagaagtt caaggaccgt ttcactataa gcgtagataa atccaaaaac     1500

acagcctacc tgcaaatgaa cagcctgcgt gctgaggaca ctgccgtcta ttattgtgct     1560

agaagcggat actacggcga tagtgactgg tattttgacg tgtggggtca aggaaccctg     1620

gtcaccgtct cctcgactag tggcggagga ggatcactcg agagcggaca ggtgctgctg     1680

gaatccaata tcaaagtcct gcccacttgg tctacccccg tgcagcctat ggctctgatt     1740

gtgctgggag gagtcgcagg actgctgctg tttatcgggc tgggaatttt cttttgcgtg     1800

cgctgccggc accggagaag gcaggccgag cgcatgagcc agatcaagcg actgctgagc     1860

gagaagaaaa cctgtcagtg tccccataga ttccagaaga cctgttcacc catttga        1917


<210> 71
<211> 617
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> 1162 TAC (w/o leader sequence)

<400> 71
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Tyr Tyr Ser 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Pro Tyr Tyr Gly Tyr Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Gly Tyr Ala Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly 
        115                 120                 125             


Glu Gly Ser Thr Lys Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
    130                 135                 140                 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
145                 150                 155                 160 


Gln Ser Val Ser Ser Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
                165                 170                 175     


Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val 
            180                 185                 190         


Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Ser Val Trp Val Gly Tyr Ser Leu Ile Thr Phe Gly Gln Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Pro 
                245                 250                 255     


Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Gly Ser Met Asp Ile Gln Met Thr Gln Ser Pro 
        275                 280                 285             


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
    290                 295                 300                 


Ala Ser Gln Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
305                 310                 315                 320 


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu Glu Ser 
                325                 330                 335     


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 
            340                 345                 350         


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
        355                 360                 365             


Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val 
    370                 375                 380                 


Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
385                 390                 395                 400 


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
                405                 410                 415     


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Phe Thr 
            420                 425                 430         


Gly Tyr Thr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
        435                 440                 445             


Trp Val Ala Leu Ile Asn Pro Thr Lys Gly Val Ser Thr Tyr Asn Gln 
    450                 455                 460                 


Lys Phe Lys Asp Arg Phe Thr Ile Ser Val Asp Lys Ser Lys Asn Thr 
465                 470                 475                 480 


Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                485                 490                 495     


Tyr Cys Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp 
            500                 505                 510         


Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Ser Gly Gly 
        515                 520                 525             


Gly Gly Ser Leu Glu Ser Gly Gln Val Leu Leu Glu Ser Asn Ile Lys 
    530                 535                 540                 


Val Leu Pro Thr Trp Ser Thr Pro Val Gln Pro Met Ala Leu Ile Val 
545                 550                 555                 560 


Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile Gly Leu Gly Ile Phe 
                565                 570                 575     


Phe Cys Val Arg Cys Arg His Arg Arg Arg Gln Ala Glu Arg Met Ser 
            580                 585                 590         


Gln Ile Lys Arg Leu Leu Ser Glu Lys Lys Thr Cys Gln Cys Pro His 
        595                 600                 605             


Arg Phe Gln Lys Thr Cys Ser Pro Ile 
    610                 615         


<210> 72
<211> 1854
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> 1162 TAC (w/o leader sequence)

<400> 72
gaggtgcagc tcgtggaaag cggcggaggg ctggtccagc caggcggctc cctgaggctg       60

tcttgcgcag caagcggctt caacatctac tatagctaca tgcattgggt ccgccaggct      120

cctggcaaag gactggaatg ggtggcctcc atctctccat actatggcta cacctcctat      180

gccgactctg tgaagggccg gtttacaatc agcgccgata cctccaagaa cacagcctat      240

ctgcagatga attccctgag ggcagaggac accgccgtgt actattgcgc cagacacggc      300

tacgccctgg attattgggg ccagggcacc ctggtgacag tgagctccgg cagcacatcc      360

ggatctggca agccaggctc tggagaggga agcaccaagg gcgacatcca gatgacacag      420

tccccatcta gcctgagcgc ctccgtggga gacagagtga ccatcacatg tcgcgcctct      480

cagagcgtgt cctctgccgt ggcatggtac cagcagaagc ccggcaaggc ccctaagctg      540

ctgatctaca gcgccagctc cctgtattcc ggcgtgcctt ctcggttctc cggctctaga      600

agcggcaccg actttaccct gacaatctct agcctgcagc ccgaggattt cgccacatac      660

tattgtcagc agagcgtgtg ggtgggctac tccctgatca cctttggcca gggcacaaaa      720

gtcgaaatta aggagcagaa gctgatcagc gaggaggacc tgaatcccgg gggaggagga      780

gggagcgggg gaggaggcag cggcggggga ggctctggag gaggagggag cggatccatg      840

gatatccaga tgacccagtc cccgagctcc ctgtccgcct ctgtgggcga tagggtcacc      900

atcacctgcc gtgccagtca ggacatccgt aattatctga actggtatca acagaaacca      960

ggaaaagctc cgaaactact gatttactat acctcccgcc tggagtctgg agtcccttct     1020

cgcttctctg gttctggttc tgggacggat tacactctga ccatcagcag tctgcaaccg     1080

gaagacttcg caacttatta ctgtcagcaa ggtaatactc tgccgtggac gttcggacag     1140

ggcaccaagg tggagatcaa aggcggcggc ggaagtggag gaggaggctc aggcggagga     1200

gggagcgagg ttcagctggt ggagtctggc ggtggcctgg tgcagccagg gggctcactc     1260

cgtttgtcct gtgcagcttc tggctactcc tttaccggct acactatgaa ctgggtgcgt     1320

caggccccag gtaagggcct ggaatgggtt gcactgatta atcctaccaa aggtgttagt     1380

acctacaacc agaagttcaa ggaccgtttc actataagcg tagataaatc caaaaacaca     1440

gcctacctgc aaatgaacag cctgcgtgct gaggacactg ccgtctatta ttgtgctaga     1500

agcggatact acggcgatag tgactggtat tttgacgtgt ggggtcaagg aaccctggtc     1560

accgtctcct cgactagtgg cggaggagga tcactcgaga gcggacaggt gctgctggaa     1620

tccaatatca aagtcctgcc cacttggtct acccccgtgc agcctatggc tctgattgtg     1680

ctgggaggag tcgcaggact gctgctgttt atcgggctgg gaattttctt ttgcgtgcgc     1740

tgccggcacc ggagaaggca ggccgagcgc atgagccaga tcaagcgact gctgagcgag     1800

aagaaaacct gtcagtgtcc ccatagattc cagaagacct gttcacccat ttga           1854


<210> 73
<211> 638
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> 1162 TAC (w/ leader sequence)

<400> 73
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Asn Ile Tyr Tyr Ser Tyr Met His Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ala Ser Ile Ser Pro Tyr Tyr Gly Tyr Thr Ser 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser 
                85                  90                  95      


Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg His Gly Tyr Ala Leu Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Ser Thr Ser Gly Ser Gly 
    130                 135                 140                 


Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Asp Ile Gln Met Thr 
145                 150                 155                 160 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
                165                 170                 175     


Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala Trp Tyr Gln 
            180                 185                 190         


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Ser 
        195                 200                 205             


Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr 
    210                 215                 220                 


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
225                 230                 235                 240 


Tyr Tyr Cys Gln Gln Ser Val Trp Val Gly Tyr Ser Leu Ile Thr Phe 
                245                 250                 255     


Gly Gln Gly Thr Lys Val Glu Ile Lys Glu Gln Lys Leu Ile Ser Glu 
            260                 265                 270         


Glu Asp Leu Asn Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Ser Met Asp Ile Gln 
    290                 295                 300                 


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
305                 310                 315                 320 


Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr Leu Asn Trp 
                325                 330                 335     


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr 
            340                 345                 350         


Ser Arg Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
        355                 360                 365             


Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
    370                 375                 380                 


Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe Gly 
385                 390                 395                 400 


Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly 
                405                 410                 415     


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
            420                 425                 430         


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
        435                 440                 445             


Gly Tyr Ser Phe Thr Gly Tyr Thr Met Asn Trp Val Arg Gln Ala Pro 
    450                 455                 460                 


Gly Lys Gly Leu Glu Trp Val Ala Leu Ile Asn Pro Thr Lys Gly Val 
465                 470                 475                 480 


Ser Thr Tyr Asn Gln Lys Phe Lys Asp Arg Phe Thr Ile Ser Val Asp 
                485                 490                 495     


Lys Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
            500                 505                 510         


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Gly Tyr Tyr Gly Asp Ser 
        515                 520                 525             


Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
    530                 535                 540                 


Ser Thr Ser Gly Gly Gly Gly Ser Leu Glu Ser Gly Gln Val Leu Leu 
545                 550                 555                 560 


Glu Ser Asn Ile Lys Val Leu Pro Thr Trp Ser Thr Pro Val Gln Pro 
                565                 570                 575     


Met Ala Leu Ile Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile 
            580                 585                 590         


Gly Leu Gly Ile Phe Phe Cys Val Arg Cys Arg His Arg Arg Arg Gln 
        595                 600                 605             


Ala Glu Arg Met Ser Gln Ile Lys Arg Leu Leu Ser Glu Lys Lys Thr 
    610                 615                 620                 


Cys Gln Cys Pro His Arg Phe Gln Lys Thr Cys Ser Pro Ile 
625                 630                 635             


<210> 74
<211> 1917
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> 1162 TAC (w/ leader sequence)

<400> 74
atggccctgc cagtgaccgc cctgctgctg ccactggccc tgctgctgca cgccgccaga       60

cccgaggtgc agctcgtgga aagcggcgga gggctggtcc agccaggcgg ctccctgagg      120

ctgtcttgcg cagcaagcgg cttcaacatc tactatagct acatgcattg ggtccgccag      180

gctcctggca aaggactgga atgggtggcc tccatctctc catactatgg ctacacctcc      240

tatgccgact ctgtgaaggg ccggtttaca atcagcgccg atacctccaa gaacacagcc      300

tatctgcaga tgaattccct gagggcagag gacaccgccg tgtactattg cgccagacac      360

ggctacgccc tggattattg gggccagggc accctggtga cagtgagctc cggcagcaca      420

tccggatctg gcaagccagg ctctggagag ggaagcacca agggcgacat ccagatgaca      480

cagtccccat ctagcctgag cgcctccgtg ggagacagag tgaccatcac atgtcgcgcc      540

tctcagagcg tgtcctctgc cgtggcatgg taccagcaga agcccggcaa ggcccctaag      600

ctgctgatct acagcgccag ctccctgtat tccggcgtgc cttctcggtt ctccggctct      660

agaagcggca ccgactttac cctgacaatc tctagcctgc agcccgagga tttcgccaca      720

tactattgtc agcagagcgt gtgggtgggc tactccctga tcacctttgg ccagggcaca      780

aaagtcgaaa ttaaggagca gaagctgatc agcgaggagg acctgaatcc cgggggagga      840

ggagggagcg ggggaggagg cagcggcggg ggaggctctg gaggaggagg gagcggatcc      900

atggatatcc agatgaccca gtccccgagc tccctgtccg cctctgtggg cgatagggtc      960

accatcacct gccgtgccag tcaggacatc cgtaattatc tgaactggta tcaacagaaa     1020

ccaggaaaag ctccgaaact actgatttac tatacctccc gcctggagtc tggagtccct     1080

tctcgcttct ctggttctgg ttctgggacg gattacactc tgaccatcag cagtctgcaa     1140

ccggaagact tcgcaactta ttactgtcag caaggtaata ctctgccgtg gacgttcgga     1200

cagggcacca aggtggagat caaaggcggc ggcggaagtg gaggaggagg ctcaggcgga     1260

ggagggagcg aggttcagct ggtggagtct ggcggtggcc tggtgcagcc agggggctca     1320

ctccgtttgt cctgtgcagc ttctggctac tcctttaccg gctacactat gaactgggtg     1380

cgtcaggccc caggtaaggg cctggaatgg gttgcactga ttaatcctac caaaggtgtt     1440

agtacctaca accagaagtt caaggaccgt ttcactataa gcgtagataa atccaaaaac     1500

acagcctacc tgcaaatgaa cagcctgcgt gctgaggaca ctgccgtcta ttattgtgct     1560

agaagcggat actacggcga tagtgactgg tattttgacg tgtggggtca aggaaccctg     1620

gtcaccgtct cctcgactag tggcggagga ggatcactcg agagcggaca ggtgctgctg     1680

gaatccaata tcaaagtcct gcccacttgg tctacccccg tgcagcctat ggctctgatt     1740

gtgctgggag gagtcgcagg actgctgctg tttatcgggc tgggaatttt cttttgcgtg     1800

cgctgccggc accggagaag gcaggccgag cgcatgagcc agatcaagcg actgctgagc     1860

gagaagaaaa cctgtcagtg tccccataga ttccagaaga cctgttcacc catttga        1917


<210> 75
<211> 635
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> 1002 TAC (w/ leader Sequence)

<400> 75
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln 
        35                  40                  45              


Ser Val Ser Ser Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
    50                  55                  60                  


Pro Lys Leu Leu Ile Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser 
            100                 105                 110         


Val Trp Val Gly Tyr Ser Leu Ile Thr Phe Gly Gln Gly Thr Lys Val 
        115                 120                 125             


Glu Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu 
    130                 135                 140                 


Gly Ser Thr Lys Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Asn Ile Tyr Tyr Ser Tyr Met His Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ala Ser Ile Ser Pro Tyr Tyr Gly Tyr Thr Ser 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser 
    210                 215                 220                 


Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg His Gly Tyr Ala Leu Asp Tyr Trp Gly 
                245                 250                 255     


Gln Gly Thr Leu Val Thr Val Ser Ser Glu Gln Lys Leu Ile Ser Glu 
            260                 265                 270         


Glu Asp Leu Asn Pro Gly Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala 
        275                 280                 285             


Lys Glu Ala Ala Ala Lys Ala Gly Ser Met Asp Ile Gln Met Thr Gln 
    290                 295                 300                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
305                 310                 315                 320 


Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln 
                325                 330                 335     


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu 
            340                 345                 350         


Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        355                 360                 365             


Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
    370                 375                 380                 


Tyr Cys Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe Gly Gln Gly Thr 
385                 390                 395                 400 


Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                405                 410                 415     


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
            420                 425                 430         


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser 
        435                 440                 445             


Phe Thr Gly Tyr Thr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly 
    450                 455                 460                 


Leu Glu Trp Val Ala Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr 
465                 470                 475                 480 


Asn Gln Lys Phe Lys Asp Arg Phe Thr Ile Ser Val Asp Lys Ser Lys 
                485                 490                 495     


Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            500                 505                 510         


Val Tyr Tyr Cys Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr 
        515                 520                 525             


Phe Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Ser 
    530                 535                 540                 


Gly Gly Gly Gly Ser Leu Glu Ser Gly Gln Val Leu Leu Glu Ser Asn 
545                 550                 555                 560 


Ile Lys Val Leu Pro Thr Trp Ser Thr Pro Val Gln Pro Met Ala Leu 
                565                 570                 575     


Ile Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile Gly Leu Gly 
            580                 585                 590         


Ile Phe Phe Cys Val Arg Cys Arg His Arg Arg Arg Gln Ala Glu Arg 
        595                 600                 605             


Met Ser Gln Ile Lys Arg Leu Leu Ser Glu Lys Lys Thr Cys Gln Cys 
    610                 615                 620                 


Pro His Arg Phe Gln Lys Thr Cys Ser Pro Ile 
625                 630                 635 


<210> 76
<211> 635
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> 1042 TAC (w/ leader Sequence)

<400> 76
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Asn Ile Tyr Tyr Ser Tyr Met His Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ala Ser Ile Ser Pro Tyr Tyr Gly Tyr Thr Ser 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser 
                85                  90                  95      


Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg His Gly Tyr Ala Leu Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Ser Thr Ser Gly Ser Gly 
    130                 135                 140                 


Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Asp Ile Gln Met Thr 
145                 150                 155                 160 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
                165                 170                 175     


Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala Trp Tyr Gln 
            180                 185                 190         


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Ser 
        195                 200                 205             


Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr 
    210                 215                 220                 


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
225                 230                 235                 240 


Tyr Tyr Cys Gln Gln Ser Val Trp Val Gly Tyr Ser Leu Ile Thr Phe 
                245                 250                 255     


Gly Gln Gly Thr Lys Val Glu Ile Lys Glu Gln Lys Leu Ile Ser Glu 
            260                 265                 270         


Glu Asp Leu Asn Pro Gly Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala 
        275                 280                 285             


Lys Glu Ala Ala Ala Lys Ala Gly Ser Met Asp Ile Gln Met Thr Gln 
    290                 295                 300                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
305                 310                 315                 320 


Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln 
                325                 330                 335     


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu 
            340                 345                 350         


Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        355                 360                 365             


Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
    370                 375                 380                 


Tyr Cys Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe Gly Gln Gly Thr 
385                 390                 395                 400 


Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                405                 410                 415     


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
            420                 425                 430         


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser 
        435                 440                 445             


Phe Thr Gly Tyr Thr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly 
    450                 455                 460                 


Leu Glu Trp Val Ala Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr 
465                 470                 475                 480 


Asn Gln Lys Phe Lys Asp Arg Phe Thr Ile Ser Val Asp Lys Ser Lys 
                485                 490                 495     


Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            500                 505                 510         


Val Tyr Tyr Cys Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr 
        515                 520                 525             


Phe Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Ser 
    530                 535                 540                 


Gly Gly Gly Gly Ser Leu Glu Ser Gly Gln Val Leu Leu Glu Ser Asn 
545                 550                 555                 560 


Ile Lys Val Leu Pro Thr Trp Ser Thr Pro Val Gln Pro Met Ala Leu 
                565                 570                 575     


Ile Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile Gly Leu Gly 
            580                 585                 590         


Ile Phe Phe Cys Val Arg Cys Arg His Arg Arg Arg Gln Ala Glu Arg 
        595                 600                 605             


Met Ser Gln Ile Lys Arg Leu Leu Ser Glu Lys Lys Thr Cys Gln Cys 
    610                 615                 620                 


Pro His Arg Phe Gln Lys Thr Cys Ser Pro Ile 
625                 630                 635 


