                         SEQUENCE LISTING

<110>  Novozymes A/S
 
<120>  ALPHA-AMYLASE POLYPEPTIDES

<130>  15077-WO-PCT

<160>  201   

<170>  PatentIn version 3.5

<210>  1
<211>  485
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1

Ala Ala Ala Pro Phe Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr 
1               5                   10                  15      


Leu Pro Asp Asp Gly Thr Leu Trp Thr Lys Val Ala Asn Glu Ala Asn 
            20                  25                  30          


Asn Leu Ser Ser Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Arg Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Ala Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Ala Gln Tyr Leu Gln Ala Ile Gln Ala Ala His Ala Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Arg Met Gly Ala Asp 
            100                 105                 110         


Ala Thr Glu Thr Ile Ser Ala Val Glu Val Asn Pro Ser Asn Arg Asn 
        115                 120                 125             


Gln Val Thr Ser Gly Ala Tyr Asn Ile Ser Ala Trp Thr Asp Phe Glu 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp His Ser Tyr 
145                 150                 155                 160 


Tyr Phe Asp Gly Val Asp Trp Asp Gln Ser Arg Gln Leu Ser Gly Lys 
                165                 170                 175     


Ile Tyr Gln Ile Gln Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Asp 
            180                 185                 190         


Ser Glu Asn Gly Asn Tyr Asp Tyr Leu Met Gly Ala Asp Ile Asp Met 
        195                 200                 205             


Asp His Pro Glu Val Val Thr Glu Leu Lys Asn Trp Gly Lys Trp Tyr 
    210                 215                 220                 


Val Asn Thr Thr Asn Ile Asp Gly Phe Arg Leu Asp Ala Val Lys His 
225                 230                 235                 240 


Ile Lys Phe Ser Phe Phe Pro Asp Trp Leu Ser Tyr Val Arg Ser Gln 
                245                 250                 255     


Thr Gly Lys Pro Leu Phe Thr Val Gly Glu Tyr Trp Ser Tyr Asp Ile 
            260                 265                 270         


Asn Lys Leu His Asn Tyr Ile Met Lys Thr Asn Gly Thr Met Ser Leu 
        275                 280                 285             


Phe Asp Ala Pro Leu His Asn Lys Phe Tyr Thr Ala Ser Lys Ser Gly 
    290                 295                 300                 


Gly Thr Phe Asp Met Arg Thr Leu Met Thr Asn Thr Leu Met Lys Asp 
305                 310                 315                 320 


Gln Pro Thr Leu Ala Val Thr Phe Val Asp Asn His Asp Thr Glu Pro 
                325                 330                 335     


Gly Gln Ala Leu Gln Ser Trp Val Asp Pro Trp Phe Lys Pro Leu Ala 
            340                 345                 350         


Tyr Ala Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr 
        355                 360                 365             


Gly Asp Tyr Tyr Gly Ile Pro Gln Tyr Asn Ile Pro Ser Leu Lys Ser 
    370                 375                 380                 


Lys Ile Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr 
385                 390                 395                 400 


Gln His Asp Tyr Leu Asp His Ser Asp Ile Ile Gly Trp Thr Arg Glu 
                405                 410                 415     


Gly Val Thr Glu Lys Pro Gly Ser Gly Leu Ala Ala Leu Ile Thr Asp 
            420                 425                 430         


Gly Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Gln His Ala Gly 
        435                 440                 445             


Lys Val Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile 
    450                 455                 460                 


Asn Ser Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser 
465                 470                 475                 480 


Val Trp Val Pro Arg 
                485 


<210>  2
<211>  484
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2

Ala Ala Ala Pro Phe Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr 
1               5                   10                  15      


Leu Pro Asp Asp Gly Thr Leu Trp Thr Lys Val Ala Asn Glu Ala Asn 
            20                  25                  30          


Asn Leu Ser Ser Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Arg Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Ala Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Ala Gln Tyr Leu Gln Ala Ile Gln Ala Ala His Ala Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Lys Ala Gly Ala Asp 
            100                 105                 110         


Ala Thr Glu Asp Val Thr Ala Val Glu Val Asn Pro Ala Asn Arg Asn 
        115                 120                 125             


Gln Glu Thr Ser Glu Glu Tyr Gln Ile Lys Ala Trp Thr Asp Phe Arg 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Asp Phe Lys Trp His Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Ala Asp Trp Asp Glu Ser Arg Lys Ile Ser Arg Ile 
                165                 170                 175     


Phe Lys Phe Arg Gly Glu Gly Lys Ala Trp Asp Trp Glu Val Ser Ser 
            180                 185                 190         


Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Val Asp Met Asp 
        195                 200                 205             


His Pro Glu Val Val Thr Glu Leu Lys Asn Trp Gly Lys Trp Tyr Val 
    210                 215                 220                 


Asn Thr Thr Asn Ile Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile 
225                 230                 235                 240 


Lys Phe Ser Phe Phe Pro Asp Trp Leu Ser Tyr Val Arg Ser Gln Thr 
                245                 250                 255     


Gly Lys Pro Leu Phe Thr Val Gly Glu Tyr Trp Ser Tyr Asp Ile Asn 
            260                 265                 270         


Lys Leu His Asn Tyr Ile Met Lys Thr Asn Gly Thr Met Ser Leu Phe 
        275                 280                 285             


Asp Ala Pro Leu His Asn Lys Phe Tyr Thr Ala Ser Lys Ser Gly Gly 
    290                 295                 300                 


Thr Phe Asp Met Arg Thr Leu Met Thr Asn Thr Leu Met Lys Asp Gln 
305                 310                 315                 320 


Pro Thr Leu Ala Val Thr Phe Val Asp Asn His Asp Thr Glu Pro Gly 
                325                 330                 335     


Gln Ala Leu Gln Ser Trp Val Asp Pro Trp Phe Lys Pro Leu Ala Tyr 
            340                 345                 350         


Ala Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr Gly 
        355                 360                 365             


Asp Tyr Tyr Gly Ile Pro Gln Tyr Asn Ile Pro Ser Leu Lys Ser Lys 
    370                 375                 380                 


Ile Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr Gln 
385                 390                 395                 400 


His Asp Tyr Leu Asp His Ser Asp Ile Ile Gly Trp Thr Arg Glu Gly 
                405                 410                 415     


Val Thr Glu Lys Pro Gly Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly 
            420                 425                 430         


Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Gln His Ala Gly Lys 
        435                 440                 445             


Val Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile Asn 
    450                 455                 460                 


Ser Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser Val 
465                 470                 475                 480 


Trp Val Pro Arg 
                


<210>  3
<211>  482
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  3

Ala Ala Ala Pro Phe Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr 
1               5                   10                  15      


Leu Pro Asp Asp Gly Thr Leu Trp Thr Lys Val Ala Asn Glu Ala Asn 
            20                  25                  30          


Asn Leu Ser Ser Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Arg Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Ala Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Ala Gln Tyr Leu Gln Ala Ile Gln Ala Ala His Ala Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Lys Gly Gly Ala Asp 
            100                 105                 110         


Ala Thr Glu Asp Val Thr Ala Val Glu Val Asp Pro Ala Asp Arg Asn 
        115                 120                 125             


Arg Val Ile Ser Gly Glu His Leu Ile Lys Ala Trp Thr His Phe His 
    130                 135                 140                 


Phe Pro Gly Arg Gly Ser Thr Tyr Ser Asp Phe Lys Trp His Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Glu Ser Arg Lys Leu Asn Arg Ile 
                165                 170                 175     


Tyr Lys Phe Gln Gly Lys Ala Trp Asp Trp Glu Val Ser Asn Glu Phe 
            180                 185                 190         


Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Ile Asp Met Asp His Pro 
        195                 200                 205             


Glu Val Val Thr Glu Leu Lys Asn Trp Gly Lys Trp Tyr Val Asn Thr 
    210                 215                 220                 


Thr Asn Ile Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile Lys Phe 
225                 230                 235                 240 


Ser Phe Phe Pro Asp Trp Leu Ser Tyr Val Arg Ser Gln Thr Gly Lys 
                245                 250                 255     


Pro Leu Phe Thr Val Gly Glu Tyr Trp Ser Tyr Asp Ile Asn Lys Leu 
            260                 265                 270         


His Asn Tyr Ile Met Lys Thr Asn Gly Thr Met Ser Leu Phe Asp Ala 
        275                 280                 285             


Pro Leu His Asn Lys Phe Tyr Thr Ala Ser Lys Ser Gly Gly Thr Phe 
    290                 295                 300                 


Asp Met Arg Thr Leu Met Thr Asn Thr Leu Met Lys Asp Gln Pro Thr 
305                 310                 315                 320 


Leu Ala Val Thr Phe Val Asp Asn His Asp Thr Glu Pro Gly Gln Ala 
                325                 330                 335     


Leu Gln Ser Trp Val Asp Pro Trp Phe Lys Pro Leu Ala Tyr Ala Phe 
            340                 345                 350         


Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr Gly Asp Tyr 
        355                 360                 365             


Tyr Gly Ile Pro Gln Tyr Asn Ile Pro Ser Leu Lys Ser Lys Ile Asp 
    370                 375                 380                 


Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr Gln His Asp 
385                 390                 395                 400 


Tyr Leu Asp His Ser Asp Ile Ile Gly Trp Thr Arg Glu Gly Val Thr 
                405                 410                 415     


Glu Lys Pro Gly Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly Pro Gly 
            420                 425                 430         


Gly Ser Lys Trp Met Tyr Val Gly Lys Gln His Ala Gly Lys Val Phe 
        435                 440                 445             


Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile Asn Ser Asp 
    450                 455                 460                 


Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser Val Trp Val 
465                 470                 475                 480 


Pro Arg 
        


<210>  4
<211>  484
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  4

Ala Ala Ala Pro Phe Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr 
1               5                   10                  15      


Leu Pro Asp Asp Gly Thr Leu Trp Thr Lys Val Ala Asn Glu Ala Asn 
            20                  25                  30          


Asn Leu Ser Ser Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Arg Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Ala Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Ala Gln Tyr Leu Gln Ala Ile Gln Ala Ala His Ala Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Lys Ala Gly Ala Asp 
            100                 105                 110         


Tyr Thr Glu Asn Val Thr Ala Val Glu Val Asn Pro Ser Asn Arg Asn 
        115                 120                 125             


Gln Glu Thr Ser Gly Glu Tyr Asn Ile Gln Ala Trp Thr Gly Phe Asn 
    130                 135                 140                 


Phe Pro Gly Arg Gly Thr Thr Tyr Ser Asn Phe Lys Trp Gln Trp Phe 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Gln Ser Arg Ser Leu Ser Arg Ile 
                165                 170                 175     


Phe Lys Phe Arg Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Ser Ser 
            180                 185                 190         


Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Ile Asp Met Asp 
        195                 200                 205             


His Pro Glu Val Val Thr Glu Leu Lys Asn Trp Gly Lys Trp Tyr Val 
    210                 215                 220                 


Asn Thr Thr Asn Ile Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile 
225                 230                 235                 240 


Lys Phe Ser Phe Phe Pro Asp Trp Leu Ser Tyr Val Arg Ser Gln Thr 
                245                 250                 255     


Gly Lys Pro Leu Phe Thr Val Gly Glu Tyr Trp Ser Tyr Asp Ile Asn 
            260                 265                 270         


Lys Leu His Asn Tyr Ile Met Lys Thr Asn Gly Thr Met Ser Leu Phe 
        275                 280                 285             


Asp Ala Pro Leu His Asn Lys Phe Tyr Thr Ala Ser Lys Ser Gly Gly 
    290                 295                 300                 


Thr Phe Asp Met Arg Thr Leu Met Thr Asn Thr Leu Met Lys Asp Gln 
305                 310                 315                 320 


Pro Thr Leu Ala Val Thr Phe Val Asp Asn His Asp Thr Glu Pro Gly 
                325                 330                 335     


Gln Ala Leu Gln Ser Trp Val Asp Pro Trp Phe Lys Pro Leu Ala Tyr 
            340                 345                 350         


Ala Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr Gly 
        355                 360                 365             


Asp Tyr Tyr Gly Ile Pro Gln Tyr Asn Ile Pro Ser Leu Lys Ser Lys 
    370                 375                 380                 


Ile Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr Gln 
385                 390                 395                 400 


His Asp Tyr Leu Asp His Ser Asp Ile Ile Gly Trp Thr Arg Glu Gly 
                405                 410                 415     


Val Thr Glu Lys Pro Gly Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly 
            420                 425                 430         


Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Gln His Ala Gly Lys 
        435                 440                 445             


Val Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile Asn 
    450                 455                 460                 


Ser Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser Val 
465                 470                 475                 480 


Trp Val Pro Arg 
                


<210>  5
<211>  484
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  5

Ala Ala Ala Pro Phe Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr 
1               5                   10                  15      


Leu Pro Asp Asp Gly Thr Leu Trp Thr Lys Val Ala Asn Glu Ala Asn 
            20                  25                  30          


Asn Leu Ser Ser Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Arg Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Ala Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Ala Gln Tyr Leu Gln Ala Ile Gln Ala Ala His Ala Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Lys Ala Gly Ala Asp 
            100                 105                 110         


Gly Thr Glu Leu Val Asp Ala Val Glu Val Asn Pro Ser Asp Arg Asn 
        115                 120                 125             


Gln Glu Ile Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Glu Ser Arg Lys Leu Asn Arg Ile 
                165                 170                 175     


Tyr Lys Phe Arg Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Asp Thr 
            180                 185                 190         


Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Leu Asp Met Asp 
        195                 200                 205             


His Pro Glu Val Val Thr Glu Leu Lys Asn Trp Gly Lys Trp Tyr Val 
    210                 215                 220                 


Asn Thr Thr Asn Ile Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile 
225                 230                 235                 240 


Lys Phe Ser Phe Phe Pro Asp Trp Leu Ser Tyr Val Arg Ser Gln Thr 
                245                 250                 255     


Gly Lys Pro Leu Phe Thr Val Gly Glu Tyr Trp Ser Tyr Asp Ile Asn 
            260                 265                 270         


Lys Leu His Asn Tyr Ile Met Lys Thr Asn Gly Thr Met Ser Leu Phe 
        275                 280                 285             


Asp Ala Pro Leu His Asn Lys Phe Tyr Thr Ala Ser Lys Ser Gly Gly 
    290                 295                 300                 


Thr Phe Asp Met Arg Thr Leu Met Thr Asn Thr Leu Met Lys Asp Gln 
305                 310                 315                 320 


Pro Thr Leu Ala Val Thr Phe Val Asp Asn His Asp Thr Glu Pro Gly 
                325                 330                 335     


Gln Ala Leu Gln Ser Trp Val Asp Pro Trp Phe Lys Pro Leu Ala Tyr 
            340                 345                 350         


Ala Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr Gly 
        355                 360                 365             


Asp Tyr Tyr Gly Ile Pro Gln Tyr Asn Ile Pro Ser Leu Lys Ser Lys 
    370                 375                 380                 


Ile Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr Gln 
385                 390                 395                 400 


His Asp Tyr Leu Asp His Ser Asp Ile Ile Gly Trp Thr Arg Glu Gly 
                405                 410                 415     


Val Thr Glu Lys Pro Gly Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly 
            420                 425                 430         


Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Gln His Ala Gly Lys 
        435                 440                 445             


Val Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile Asn 
    450                 455                 460                 


Ser Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser Val 
465                 470                 475                 480 


Trp Val Pro Arg 
                


<210>  6
<211>  484
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  6

Ala Ala Ala Pro Phe Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr 
1               5                   10                  15      


Leu Pro Asp Asp Gly Thr Leu Trp Thr Lys Val Ala Asn Glu Ala Asn 
            20                  25                  30          


Asn Leu Ser Ser Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Arg Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Ala Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Ala Gln Tyr Leu Gln Ala Ile Gln Ala Ala His Ala Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Lys Ala Gly Ala Asp 
            100                 105                 110         


Gly Thr Glu Phe Val Asp Ala Val Glu Val Asn Pro Ser Asn Arg Asn 
        115                 120                 125             


Gln Glu Thr Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Glu Ser Arg Lys Leu Asn Arg Val 
                165                 170                 175     


Tyr Lys Phe Arg Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Asp Thr 
            180                 185                 190         


Glu Asn Gly Asn Tyr Asp Tyr Leu Met Phe Ala Asp Leu Asp Met Asp 
        195                 200                 205             


His Pro Glu Val Val Thr Glu Leu Lys Asn Trp Gly Lys Trp Tyr Val 
    210                 215                 220                 


Asn Thr Thr Asn Ile Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile 
225                 230                 235                 240 


Lys Phe Ser Phe Phe Pro Asp Trp Leu Ser Tyr Val Arg Ser Gln Thr 
                245                 250                 255     


Gly Lys Pro Leu Phe Thr Val Gly Glu Tyr Trp Ser Tyr Asp Ile Asn 
            260                 265                 270         


Lys Leu His Asn Tyr Ile Met Lys Thr Asn Gly Thr Met Ser Leu Phe 
        275                 280                 285             


Asp Ala Pro Leu His Asn Lys Phe Tyr Thr Ala Ser Lys Ser Gly Gly 
    290                 295                 300                 


Thr Phe Asp Met Arg Thr Leu Met Thr Asn Thr Leu Met Lys Asp Gln 
305                 310                 315                 320 


Pro Thr Leu Ala Val Thr Phe Val Asp Asn His Asp Thr Glu Pro Gly 
                325                 330                 335     


Gln Ala Leu Gln Ser Trp Val Asp Pro Trp Phe Lys Pro Leu Ala Tyr 
            340                 345                 350         


Ala Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr Gly 
        355                 360                 365             


Asp Tyr Tyr Gly Ile Pro Gln Tyr Asn Ile Pro Ser Leu Lys Ser Lys 
    370                 375                 380                 


Ile Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr Gln 
385                 390                 395                 400 


His Asp Tyr Leu Asp His Ser Asp Ile Ile Gly Trp Thr Arg Glu Gly 
                405                 410                 415     


Val Thr Glu Lys Pro Gly Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly 
            420                 425                 430         


Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Gln His Ala Gly Lys 
        435                 440                 445             


Val Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile Asn 
    450                 455                 460                 


Ser Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser Val 
465                 470                 475                 480 


Trp Val Pro Arg 
                


<210>  7
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  7

Ala Ala Ala Pro Phe Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr 
1               5                   10                  15      


Leu Pro Asp Asp Gly Thr Leu Trp Thr Lys Val Ala Asn Glu Ala Asn 
            20                  25                  30          


Asn Leu Ser Ser Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Arg Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Ala Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Ala Gln Tyr Leu Gln Ala Ile Gln Ala Ala His Ala Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Lys Ala Gly Ala Asp 
            100                 105                 110         


Gly Thr Glu Phe Val Asp Ala Val Glu Val Asp Pro Ser Asn Arg Asn 
        115                 120                 125             


Gln Glu Thr Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Glu Ser Arg Lys Leu Asn Arg Ile 
                165                 170                 175     


Tyr Lys Phe Ser Thr Gly Lys Ala Trp Asp Trp Glu Val Asp Thr Glu 
            180                 185                 190         


Asn Gly Asn Tyr Asp Tyr Leu Met Phe Ala Asp Leu Asp Met Asp His 
        195                 200                 205             


Pro Glu Val Val Thr Glu Leu Lys Asn Trp Gly Lys Trp Tyr Val Asn 
    210                 215                 220                 


Thr Thr Asn Ile Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile Lys 
225                 230                 235                 240 


Phe Ser Phe Phe Pro Asp Trp Leu Ser Tyr Val Arg Ser Gln Thr Gly 
                245                 250                 255     


Lys Pro Leu Phe Thr Val Gly Glu Tyr Trp Ser Tyr Asp Ile Asn Lys 
            260                 265                 270         


Leu His Asn Tyr Ile Met Lys Thr Asn Gly Thr Met Ser Leu Phe Asp 
        275                 280                 285             


Ala Pro Leu His Asn Lys Phe Tyr Thr Ala Ser Lys Ser Gly Gly Thr 
    290                 295                 300                 


Phe Asp Met Arg Thr Leu Met Thr Asn Thr Leu Met Lys Asp Gln Pro 
305                 310                 315                 320 


Thr Leu Ala Val Thr Phe Val Asp Asn His Asp Thr Glu Pro Gly Gln 
                325                 330                 335     


Ala Leu Gln Ser Trp Val Asp Pro Trp Phe Lys Pro Leu Ala Tyr Ala 
            340                 345                 350         


Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr Gly Asp 
        355                 360                 365             


Tyr Tyr Gly Ile Pro Gln Tyr Asn Ile Pro Ser Leu Lys Ser Lys Ile 
    370                 375                 380                 


Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr Gln His 
385                 390                 395                 400 


Asp Tyr Leu Asp His Ser Asp Ile Ile Gly Trp Thr Arg Glu Gly Val 
                405                 410                 415     


Thr Glu Lys Pro Gly Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly Pro 
            420                 425                 430         


Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Gln His Ala Gly Lys Val 
        435                 440                 445             


Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile Asn Ser 
    450                 455                 460                 


Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser Val Trp 
465                 470                 475                 480 


Val Pro Arg 
            


<210>  8
<211>  484
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sythetic Construct

<400>  8

Ala Ala Ala Pro Phe Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr 
1               5                   10                  15      


Leu Pro Asp Asp Gly Thr Leu Trp Thr Lys Val Ala Asn Glu Ala Asn 
            20                  25                  30          


Asn Leu Ser Ser Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Arg Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Ala Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Ala Gln Tyr Leu Gln Ala Ile Gln Ala Ala His Ala Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Lys Ala Gly Ala Asp 
            100                 105                 110         


Gly Thr Glu Phe Val Asp Ala Val Glu Val Asn Pro Ser Asn Arg Asn 
        115                 120                 125             


Gln Glu Thr Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Glu Ser Arg Lys Leu Asn Arg Ile 
                165                 170                 175     


Tyr Lys Phe Arg Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Asp Thr 
            180                 185                 190         


Glu Asn Gly Asn Tyr Asp Tyr Leu Met Phe Ala Asp Leu Asp Met Asp 
        195                 200                 205             


His Pro Glu Val Val Thr Glu Leu Lys Asn Trp Gly Lys Trp Tyr Val 
    210                 215                 220                 


Asn Thr Thr Asn Ile Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile 
225                 230                 235                 240 


Lys Phe Ser Phe Phe Pro Asp Trp Leu Ser Tyr Val Arg Ser Gln Thr 
                245                 250                 255     


Gly Lys Pro Leu Phe Thr Val Gly Glu Tyr Trp Ser Tyr Asp Ile Asn 
            260                 265                 270         


Lys Leu His Asn Tyr Ile Met Lys Thr Asn Gly Thr Met Ser Leu Phe 
        275                 280                 285             


Asp Ala Pro Leu His Asn Lys Phe Tyr Thr Ala Ser Lys Ser Gly Gly 
    290                 295                 300                 


Thr Phe Asp Met Arg Thr Leu Met Thr Asn Thr Leu Met Lys Asp Gln 
305                 310                 315                 320 


Pro Thr Leu Ala Val Thr Phe Val Asp Asn His Asp Thr Glu Pro Gly 
                325                 330                 335     


Gln Ala Leu Gln Ser Trp Val Asp Pro Trp Phe Lys Pro Leu Ala Tyr 
            340                 345                 350         


Ala Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr Gly 
        355                 360                 365             


Asp Tyr Tyr Gly Ile Pro Gln Tyr Asn Ile Pro Ser Leu Lys Ser Lys 
    370                 375                 380                 


Ile Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr Gln 
385                 390                 395                 400 


His Asp Tyr Leu Asp His Ser Asp Ile Ile Gly Trp Thr Arg Glu Gly 
                405                 410                 415     


Val Thr Glu Lys Pro Gly Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly 
            420                 425                 430         


Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Gln His Ala Gly Lys 
        435                 440                 445             


Val Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile Asn 
    450                 455                 460                 


Ser Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser Val 
465                 470                 475                 480 


Trp Val Pro Arg 
                


<210>  9
<211>  484
<212>  PRT
<213>  Artifical Sequence

<400>  9

Ala Ala Ala Pro Phe Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr 
1               5                   10                  15      


Leu Pro Asp Asp Gly Thr Leu Trp Thr Lys Val Ala Asn Glu Ala Asn 
            20                  25                  30          


Asn Leu Ser Ser Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Arg Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Ala Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Ala Gln Tyr Leu Gln Ala Ile Gln Ala Ala His Ala Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Lys Ala Gly Ala Asp 
            100                 105                 110         


Ala Thr Glu Trp Val Asp Ala Val Glu Val Asn Pro Ser Asn Arg Asn 
        115                 120                 125             


Gln Glu Val Ser Gly Thr Tyr Lys Ile Gln Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Gln Ser Arg Gln Leu Asn Arg Ile 
                165                 170                 175     


Tyr Lys Phe Arg Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Asp Thr 
            180                 185                 190         


Glu Asn Gly Asn Tyr Asp Tyr Leu Met Phe Ala Asp Leu Asp Met Asp 
        195                 200                 205             


His Pro Glu Val Val Thr Glu Leu Lys Asn Trp Gly Lys Trp Tyr Val 
    210                 215                 220                 


Asn Thr Thr Asn Ile Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile 
225                 230                 235                 240 


Lys Phe Ser Phe Phe Pro Asp Trp Leu Ser Tyr Val Arg Ser Gln Thr 
                245                 250                 255     


Gly Lys Pro Leu Phe Thr Val Gly Glu Tyr Trp Ser Tyr Asp Ile Asn 
            260                 265                 270         


Lys Leu His Asn Tyr Ile Met Lys Thr Asn Gly Thr Met Ser Leu Phe 
        275                 280                 285             


Asp Ala Pro Leu His Asn Lys Phe Tyr Thr Ala Ser Lys Ser Gly Gly 
    290                 295                 300                 


Thr Phe Asp Met Arg Thr Leu Met Thr Asn Thr Leu Met Lys Asp Gln 
305                 310                 315                 320 


Pro Thr Leu Ala Val Thr Phe Val Asp Asn His Asp Thr Glu Pro Gly 
                325                 330                 335     


Gln Ala Leu Gln Ser Trp Val Asp Pro Trp Phe Lys Pro Leu Ala Tyr 
            340                 345                 350         


Ala Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr Gly 
        355                 360                 365             


Asp Tyr Tyr Gly Ile Pro Gln Tyr Asn Ile Pro Ser Leu Lys Ser Lys 
    370                 375                 380                 


Ile Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr Gln 
385                 390                 395                 400 


His Asp Tyr Leu Asp His Ser Asp Ile Ile Gly Trp Thr Arg Glu Gly 
                405                 410                 415     


Val Thr Glu Lys Pro Gly Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly 
            420                 425                 430         


Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Gln His Ala Gly Lys 
        435                 440                 445             


Val Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile Asn 
    450                 455                 460                 


Ser Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser Val 
465                 470                 475                 480 


Trp Val Pro Arg 
                


<210>  10
<211>  484
<212>  PRT
<213>  Artifical Sequence

<400>  10

Ala Ala Ala Pro Phe Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr 
1               5                   10                  15      


Leu Pro Asp Asp Gly Thr Leu Trp Thr Lys Val Ala Asn Glu Ala Asn 
            20                  25                  30          


Asn Leu Ser Ser Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Arg Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Ala Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Ala Gln Tyr Leu Gln Ala Ile Gln Ala Ala His Ala Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Lys Ala Gly Ala Asp 
            100                 105                 110         


Ser Thr Glu Trp Val Asp Ala Val Glu Val Asn Pro Ser Asn Arg Asn 
        115                 120                 125             


Gln Glu Thr Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Glu Ser Arg Lys Leu Asn Arg Ile 
                165                 170                 175     


Tyr Lys Phe Arg Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Asp Thr 
            180                 185                 190         


Glu Asn Gly Asn Tyr Asp Tyr Leu Met Phe Ala Asp Leu Asp Met Asp 
        195                 200                 205             


His Pro Glu Val Val Thr Glu Leu Lys Asn Trp Gly Lys Trp Tyr Val 
    210                 215                 220                 


Asn Thr Thr Asn Ile Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile 
225                 230                 235                 240 


Lys Phe Ser Phe Phe Pro Asp Trp Leu Ser Tyr Val Arg Ser Gln Thr 
                245                 250                 255     


Gly Lys Pro Leu Phe Thr Val Gly Glu Tyr Trp Ser Tyr Asp Ile Asn 
            260                 265                 270         


Lys Leu His Asn Tyr Ile Met Lys Thr Asn Gly Thr Met Ser Leu Phe 
        275                 280                 285             


Asp Ala Pro Leu His Asn Lys Phe Tyr Thr Ala Ser Lys Ser Gly Gly 
    290                 295                 300                 


Thr Phe Asp Met Arg Thr Leu Met Thr Asn Thr Leu Met Lys Asp Gln 
305                 310                 315                 320 


Pro Thr Leu Ala Val Thr Phe Val Asp Asn His Asp Thr Glu Pro Gly 
                325                 330                 335     


Gln Ala Leu Gln Ser Trp Val Asp Pro Trp Phe Lys Pro Leu Ala Tyr 
            340                 345                 350         


Ala Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr Gly 
        355                 360                 365             


Asp Tyr Tyr Gly Ile Pro Gln Tyr Asn Ile Pro Ser Leu Lys Ser Lys 
    370                 375                 380                 


Ile Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr Gln 
385                 390                 395                 400 


His Asp Tyr Leu Asp His Ser Asp Ile Ile Gly Trp Thr Arg Glu Gly 
                405                 410                 415     


Val Thr Glu Lys Pro Gly Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly 
            420                 425                 430         


Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Gln His Ala Gly Lys 
        435                 440                 445             


Val Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile Asn 
    450                 455                 460                 


Ser Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser Val 
465                 470                 475                 480 


Trp Val Pro Arg 
                


<210>  11
<211>  485
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  11

Ala Ala Ala Pro Phe Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr 
1               5                   10                  15      


Leu Pro Asp Asp Gly Thr Leu Trp Thr Lys Val Ala Asn Glu Ala Asn 
            20                  25                  30          


Asn Leu Ser Ser Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Arg Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Ala Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Ala Gln Tyr Leu Gln Ala Ile Gln Ala Ala His Ala Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Lys Gly Gly Ala Asp 
            100                 105                 110         


Phe Thr Glu Arg Val Gln Ala Val Glu Val Asn Pro Gln Asn Arg Asn 
        115                 120                 125             


Gln Glu Val Ser Gly Thr Tyr Gln Ile Glu Ala Trp Thr Gly Phe Asn 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Gln His Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Gln Ser Arg Gln Leu Ala Asn Arg 
                165                 170                 175     


Ile Tyr Lys Phe Arg Gly Asp Gly Lys Ala Trp Asp Trp Glu Val Asp 
            180                 185                 190         


Thr Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Val Asp Met 
        195                 200                 205             


Asp His Pro Glu Val Val Thr Glu Leu Lys Asn Trp Gly Lys Trp Tyr 
    210                 215                 220                 


Val Asn Thr Thr Asn Ile Asp Gly Phe Arg Leu Asp Ala Val Lys His 
225                 230                 235                 240 


Ile Lys Phe Ser Phe Phe Pro Asp Trp Leu Ser Tyr Val Arg Ser Gln 
                245                 250                 255     


Thr Gly Lys Pro Leu Phe Thr Val Gly Glu Tyr Trp Ser Tyr Asp Ile 
            260                 265                 270         


Asn Lys Leu His Asn Tyr Ile Met Lys Thr Asn Gly Thr Met Ser Leu 
        275                 280                 285             


Phe Asp Ala Pro Leu His Asn Lys Phe Tyr Thr Ala Ser Lys Ser Gly 
    290                 295                 300                 


Gly Thr Phe Asp Met Arg Thr Leu Met Thr Asn Thr Leu Met Lys Asp 
305                 310                 315                 320 


Gln Pro Thr Leu Ala Val Thr Phe Val Asp Asn His Asp Thr Glu Pro 
                325                 330                 335     


Gly Gln Ala Leu Gln Ser Trp Val Asp Pro Trp Phe Lys Pro Leu Ala 
            340                 345                 350         


Tyr Ala Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr 
        355                 360                 365             


Gly Asp Tyr Tyr Gly Ile Pro Gln Tyr Asn Ile Pro Ser Leu Lys Ser 
    370                 375                 380                 


Lys Ile Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr 
385                 390                 395                 400 


Gln His Asp Tyr Leu Asp His Ser Asp Ile Ile Gly Trp Thr Arg Glu 
                405                 410                 415     


Gly Val Thr Glu Lys Pro Gly Ser Gly Leu Ala Ala Leu Ile Thr Asp 
            420                 425                 430         


Gly Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Gln His Ala Gly 
        435                 440                 445             


Lys Val Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile 
    450                 455                 460                 


Asn Ser Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser 
465                 470                 475                 480 


Val Trp Val Pro Arg 
                485 


<210>  12
<211>  485
<212>  PRT
<213>  Artifical Sequence

<400>  12

Ala Ala Ala Pro Phe Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr 
1               5                   10                  15      


Leu Pro Asp Asp Gly Thr Leu Trp Thr Lys Val Ala Asn Glu Ala Asn 
            20                  25                  30          


Asn Leu Ser Ser Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Arg Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Ala Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Ala Gln Tyr Leu Gln Ala Ile Gln Ala Ala His Ala Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Lys Gly Gly Ala Asp 
            100                 105                 110         


Ala Thr Glu Asn Val Leu Ala Val Glu Val Asn Pro Asn Asn Arg Asn 
        115                 120                 125             


Gln Glu Ile Ser Gly Asp Tyr Thr Ile Glu Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Asp Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Val Asp Trp Asp Gln Ser Arg Gln Phe Gln Asn Arg 
                165                 170                 175     


Ile Tyr Lys Phe Arg Gly Asp Gly Lys Ala Trp Asp Trp Glu Val Asp 
            180                 185                 190         


Ser Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Val Asp Met 
        195                 200                 205             


Asp His Pro Glu Val Val Thr Glu Leu Lys Asn Trp Gly Lys Trp Tyr 
    210                 215                 220                 


Val Asn Thr Thr Asn Ile Asp Gly Phe Arg Leu Asp Ala Val Lys His 
225                 230                 235                 240 


Ile Lys Phe Ser Phe Phe Pro Asp Trp Leu Ser Tyr Val Arg Ser Gln 
                245                 250                 255     


Thr Gly Lys Pro Leu Phe Thr Val Gly Glu Tyr Trp Ser Tyr Asp Ile 
            260                 265                 270         


Asn Lys Leu His Asn Tyr Ile Met Lys Thr Asn Gly Thr Met Ser Leu 
        275                 280                 285             


Phe Asp Ala Pro Leu His Asn Lys Phe Tyr Thr Ala Ser Lys Ser Gly 
    290                 295                 300                 


Gly Thr Phe Asp Met Arg Thr Leu Met Thr Asn Thr Leu Met Lys Asp 
305                 310                 315                 320 


Gln Pro Thr Leu Ala Val Thr Phe Val Asp Asn His Asp Thr Glu Pro 
                325                 330                 335     


Gly Gln Ala Leu Gln Ser Trp Val Asp Pro Trp Phe Lys Pro Leu Ala 
            340                 345                 350         


Tyr Ala Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr 
        355                 360                 365             


Gly Asp Tyr Tyr Gly Ile Pro Gln Tyr Asn Ile Pro Ser Leu Lys Ser 
    370                 375                 380                 


Lys Ile Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr 
385                 390                 395                 400 


Gln His Asp Tyr Leu Asp His Ser Asp Ile Ile Gly Trp Thr Arg Glu 
                405                 410                 415     


Gly Val Thr Glu Lys Pro Gly Ser Gly Leu Ala Ala Leu Ile Thr Asp 
            420                 425                 430         


Gly Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Gln His Ala Gly 
        435                 440                 445             


Lys Val Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile 
    450                 455                 460                 


Asn Ser Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser 
465                 470                 475                 480 


Val Trp Val Pro Arg 
                485 


<210>  13
<211>  485
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  13

Ala Ala Ala Pro Phe Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr 
1               5                   10                  15      


Leu Pro Asp Asp Gly Thr Leu Trp Thr Lys Val Ala Asn Glu Ala Asn 
            20                  25                  30          


Asn Leu Ser Ser Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Arg Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Ala Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Ala Gln Tyr Leu Gln Ala Ile Gln Ala Ala His Ala Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Lys Gly Gly Ala Asp 
            100                 105                 110         


Ala Thr Glu Met Val Arg Ala Val Glu Val Asn Pro Asn Asn Arg Asn 
        115                 120                 125             


Gln Glu Val Ser Gly Glu Tyr Thr Ile Glu Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr His Ser Asn Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Val Asp Trp Asp Gln Ser Arg Lys Leu Asn Asn Arg 
                165                 170                 175     


Ile Tyr Lys Phe Arg Gly Asp Gly Lys Gly Trp Asp Trp Glu Val Asp 
            180                 185                 190         


Thr Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Ile Asp Met 
        195                 200                 205             


Asp His Pro Glu Val Val Thr Glu Leu Lys Asn Trp Gly Lys Trp Tyr 
    210                 215                 220                 


Val Asn Thr Thr Asn Ile Asp Gly Phe Arg Leu Asp Ala Val Lys His 
225                 230                 235                 240 


Ile Lys Phe Ser Phe Phe Pro Asp Trp Leu Ser Tyr Val Arg Ser Gln 
                245                 250                 255     


Thr Gly Lys Pro Leu Phe Thr Val Gly Glu Tyr Trp Ser Tyr Asp Ile 
            260                 265                 270         


Asn Lys Leu His Asn Tyr Ile Met Lys Thr Asn Gly Thr Met Ser Leu 
        275                 280                 285             


Phe Asp Ala Pro Leu His Asn Lys Phe Tyr Thr Ala Ser Lys Ser Gly 
    290                 295                 300                 


Gly Thr Phe Asp Met Arg Thr Leu Met Thr Asn Thr Leu Met Lys Asp 
305                 310                 315                 320 


Gln Pro Thr Leu Ala Val Thr Phe Val Asp Asn His Asp Thr Glu Pro 
                325                 330                 335     


Gly Gln Ala Leu Gln Ser Trp Val Asp Pro Trp Phe Lys Pro Leu Ala 
            340                 345                 350         


Tyr Ala Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr 
        355                 360                 365             


Gly Asp Tyr Tyr Gly Ile Pro Gln Tyr Asn Ile Pro Ser Leu Lys Ser 
    370                 375                 380                 


Lys Ile Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr 
385                 390                 395                 400 


Gln His Asp Tyr Leu Asp His Ser Asp Ile Ile Gly Trp Thr Arg Glu 
                405                 410                 415     


Gly Val Thr Glu Lys Pro Gly Ser Gly Leu Ala Ala Leu Ile Thr Asp 
            420                 425                 430         


Gly Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Gln His Ala Gly 
        435                 440                 445             


Lys Val Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile 
    450                 455                 460                 


Asn Ser Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser 
465                 470                 475                 480 


Val Trp Val Pro Arg 
                485 


<210>  14
<211>  485
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  14

Ala Ala Ala Pro Phe Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr 
1               5                   10                  15      


Leu Pro Asp Asp Gly Thr Leu Trp Thr Lys Val Ala Asn Glu Ala Asn 
            20                  25                  30          


Asn Leu Ser Ser Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Arg Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Ala Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Ala Gln Tyr Leu Gln Ala Ile Gln Ala Ala His Ala Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Lys Gly Gly Ala Asp 
            100                 105                 110         


Ala Thr Glu Met Val Arg Ala Val Glu Val Asn Pro Asn Asn Arg Asn 
        115                 120                 125             


Gln Glu Val Thr Gly Glu Tyr Thr Ile Glu Ala Trp Thr Arg Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr His Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Val Asp Trp Asp Gln Ser Arg Arg Leu Asn Asn Arg 
                165                 170                 175     


Ile Tyr Lys Phe Arg Gly His Gly Lys Ala Trp Asp Trp Glu Val Asp 
            180                 185                 190         


Thr Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Ile Asp Met 
        195                 200                 205             


Asp His Pro Glu Val Val Thr Glu Leu Lys Asn Trp Gly Lys Trp Tyr 
    210                 215                 220                 


Val Asn Thr Thr Asn Ile Asp Gly Phe Arg Leu Asp Ala Val Lys His 
225                 230                 235                 240 


Ile Lys Phe Ser Phe Phe Pro Asp Trp Leu Ser Tyr Val Arg Ser Gln 
                245                 250                 255     


Thr Gly Lys Pro Leu Phe Thr Val Gly Glu Tyr Trp Ser Tyr Asp Ile 
            260                 265                 270         


Asn Lys Leu His Asn Tyr Ile Met Lys Thr Asn Gly Thr Met Ser Leu 
        275                 280                 285             


Phe Asp Ala Pro Leu His Asn Lys Phe Tyr Thr Ala Ser Lys Ser Gly 
    290                 295                 300                 


Gly Thr Phe Asp Met Arg Thr Leu Met Thr Asn Thr Leu Met Lys Asp 
305                 310                 315                 320 


Gln Pro Thr Leu Ala Val Thr Phe Val Asp Asn His Asp Thr Glu Pro 
                325                 330                 335     


Gly Gln Ala Leu Gln Ser Trp Val Asp Pro Trp Phe Lys Pro Leu Ala 
            340                 345                 350         


Tyr Ala Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr 
        355                 360                 365             


Gly Asp Tyr Tyr Gly Ile Pro Gln Tyr Asn Ile Pro Ser Leu Lys Ser 
    370                 375                 380                 


Lys Ile Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr 
385                 390                 395                 400 


Gln His Asp Tyr Leu Asp His Ser Asp Ile Ile Gly Trp Thr Arg Glu 
                405                 410                 415     


Gly Val Thr Glu Lys Pro Gly Ser Gly Leu Ala Ala Leu Ile Thr Asp 
            420                 425                 430         


Gly Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Gln His Ala Gly 
        435                 440                 445             


Lys Val Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile 
    450                 455                 460                 


Asn Ser Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser 
465                 470                 475                 480 


Val Trp Val Pro Arg 
                485 


<210>  15
<211>  485
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  15

Gly Ser Val Pro Val Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr 
1               5                   10                  15      


Leu Pro Asp Asp Gly Thr Leu Trp Thr Lys Val Ala Asn Asn Ala Gln 
            20                  25                  30          


Ser Leu Ala Asn Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Ser Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Thr Gln Tyr Ile Gln Ala Ile Gln Ala Ala His Thr Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Arg Met Gly Ala Asp 
            100                 105                 110         


Ala Thr Glu Thr Ile Ser Ala Val Glu Val Asn Pro Ser Asn Arg Asn 
        115                 120                 125             


Gln Val Thr Ser Gly Ala Tyr Asn Ile Ser Ala Trp Thr Asp Phe Glu 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp His Ser Tyr 
145                 150                 155                 160 


Tyr Phe Asp Gly Val Asp Trp Asp Gln Ser Arg Gln Leu Ser Gly Lys 
                165                 170                 175     


Ile Tyr Gln Ile Gln Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Asp 
            180                 185                 190         


Ser Glu Asn Gly Asn Tyr Asp Tyr Leu Met Gly Ala Asp Ile Asp Met 
        195                 200                 205             


Asp His Pro Glu Val Val Ser Glu Leu Lys Asn Trp Gly Lys Trp Tyr 
    210                 215                 220                 


Val Thr Thr Thr Asn Ile Asp Gly Phe Arg Leu Asp Ala Val Lys His 
225                 230                 235                 240 


Ile Lys Tyr Ser Phe Phe Pro Asp Trp Leu Ser Tyr Val Arg Thr Gln 
                245                 250                 255     


Thr Gln Lys Pro Leu Phe Ala Val Gly Glu Phe Trp Ser Tyr Asp Ile 
            260                 265                 270         


Ser Lys Leu His Asn Tyr Ile Thr Lys Thr Asn Gly Ser Met Ser Leu 
        275                 280                 285             


Phe Asp Ala Pro Leu His Asn Asn Phe Tyr Ile Ala Ser Lys Ser Gly 
    290                 295                 300                 


Gly Tyr Phe Asp Met Arg Thr Leu Leu Asn Asn Thr Leu Met Lys Asp 
305                 310                 315                 320 


Gln Pro Thr Leu Ala Val Thr Leu Val Asp Asn His Asp Thr Glu Pro 
                325                 330                 335     


Gly Gln Ser Leu Gln Ser Trp Val Glu Pro Trp Phe Lys Pro Leu Ala 
            340                 345                 350         


Tyr Ala Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr 
        355                 360                 365             


Gly Asp Tyr Tyr Gly Ile Pro Lys Tyr Asn Ile Pro Ala Leu Lys Ser 
    370                 375                 380                 


Lys Leu Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr 
385                 390                 395                 400 


Gln His Asp Tyr Ile Asp Ser Ala Asp Ile Ile Gly Trp Thr Arg Glu 
                405                 410                 415     


Gly Val Ala Glu Lys Ala Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp 
            420                 425                 430         


Gly Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Gln His Ala Gly 
        435                 440                 445             


Lys Thr Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile 
    450                 455                 460                 


Asn Ala Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser 
465                 470                 475                 480 


Ile Trp Val Pro Lys 
                485 


<210>  16
<211>  484
<212>  PRT
<213>  Artifical Sequence

<400>  16

Gly Ser Val Pro Val Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr 
1               5                   10                  15      


Leu Pro Asp Asp Gly Thr Leu Trp Thr Lys Val Ala Asn Asn Ala Gln 
            20                  25                  30          


Ser Leu Ala Asn Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Ser Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Thr Gln Tyr Ile Gln Ala Ile Gln Ala Ala His Thr Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Lys Ala Gly Ala Asp 
            100                 105                 110         


Ala Thr Glu Asp Val Thr Ala Val Glu Val Asn Pro Ala Asn Arg Asn 
        115                 120                 125             


Gln Glu Thr Ser Glu Glu Tyr Gln Ile Lys Ala Trp Thr Asp Phe Arg 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Asp Phe Lys Trp His Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Ala Asp Trp Asp Glu Ser Arg Lys Ile Ser Arg Ile 
                165                 170                 175     


Phe Lys Phe Arg Gly Glu Gly Lys Ala Trp Asp Trp Glu Val Ser Ser 
            180                 185                 190         


Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Val Asp Met Asp 
        195                 200                 205             


His Pro Glu Val Val Ser Glu Leu Lys Asn Trp Gly Lys Trp Tyr Val 
    210                 215                 220                 


Thr Thr Thr Asn Ile Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile 
225                 230                 235                 240 


Lys Tyr Ser Phe Phe Pro Asp Trp Leu Ser Tyr Val Arg Thr Gln Thr 
                245                 250                 255     


Gln Lys Pro Leu Phe Ala Val Gly Glu Phe Trp Ser Tyr Asp Ile Ser 
            260                 265                 270         


Lys Leu His Asn Tyr Ile Thr Lys Thr Asn Gly Ser Met Ser Leu Phe 
        275                 280                 285             


Asp Ala Pro Leu His Asn Asn Phe Tyr Ile Ala Ser Lys Ser Gly Gly 
    290                 295                 300                 


Tyr Phe Asp Met Arg Thr Leu Leu Asn Asn Thr Leu Met Lys Asp Gln 
305                 310                 315                 320 


Pro Thr Leu Ala Val Thr Leu Val Asp Asn His Asp Thr Glu Pro Gly 
                325                 330                 335     


Gln Ser Leu Gln Ser Trp Val Glu Pro Trp Phe Lys Pro Leu Ala Tyr 
            340                 345                 350         


Ala Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr Gly 
        355                 360                 365             


Asp Tyr Tyr Gly Ile Pro Lys Tyr Asn Ile Pro Ala Leu Lys Ser Lys 
    370                 375                 380                 


Leu Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr Gln 
385                 390                 395                 400 


His Asp Tyr Ile Asp Ser Ala Asp Ile Ile Gly Trp Thr Arg Glu Gly 
                405                 410                 415     


Val Ala Glu Lys Ala Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly 
            420                 425                 430         


Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Gln His Ala Gly Lys 
        435                 440                 445             


Thr Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile Asn 
    450                 455                 460                 


Ala Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser Ile 
465                 470                 475                 480 


Trp Val Pro Lys 
                


<210>  17
<211>  482
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  17

Gly Ser Val Pro Val Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr 
1               5                   10                  15      


Leu Pro Asp Asp Gly Thr Leu Trp Thr Lys Val Ala Asn Asn Ala Gln 
            20                  25                  30          


Ser Leu Ala Asn Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Ser Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Thr Gln Tyr Ile Gln Ala Ile Gln Ala Ala His Thr Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Lys Gly Gly Ala Asp 
            100                 105                 110         


Ala Thr Glu Asp Val Thr Ala Val Glu Val Asp Pro Ala Asp Arg Asn 
        115                 120                 125             


Arg Val Ile Ser Gly Glu His Leu Ile Lys Ala Trp Thr His Phe His 
    130                 135                 140                 


Phe Pro Gly Arg Gly Ser Thr Tyr Ser Asp Phe Lys Trp His Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Glu Ser Arg Lys Leu Asn Arg Ile 
                165                 170                 175     


Tyr Lys Phe Gln Gly Lys Ala Trp Asp Trp Glu Val Ser Asn Glu Phe 
            180                 185                 190         


Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Ile Asp Met Asp His Pro 
        195                 200                 205             


Glu Val Val Ser Glu Leu Lys Asn Trp Gly Lys Trp Tyr Val Thr Thr 
    210                 215                 220                 


Thr Asn Ile Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile Lys Tyr 
225                 230                 235                 240 


Ser Phe Phe Pro Asp Trp Leu Ser Tyr Val Arg Thr Gln Thr Gln Lys 
                245                 250                 255     


Pro Leu Phe Ala Val Gly Glu Phe Trp Ser Tyr Asp Ile Ser Lys Leu 
            260                 265                 270         


His Asn Tyr Ile Thr Lys Thr Asn Gly Ser Met Ser Leu Phe Asp Ala 
        275                 280                 285             


Pro Leu His Asn Asn Phe Tyr Ile Ala Ser Lys Ser Gly Gly Tyr Phe 
    290                 295                 300                 


Asp Met Arg Thr Leu Leu Asn Asn Thr Leu Met Lys Asp Gln Pro Thr 
305                 310                 315                 320 


Leu Ala Val Thr Leu Val Asp Asn His Asp Thr Glu Pro Gly Gln Ser 
                325                 330                 335     


Leu Gln Ser Trp Val Glu Pro Trp Phe Lys Pro Leu Ala Tyr Ala Phe 
            340                 345                 350         


Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr Gly Asp Tyr 
        355                 360                 365             


Tyr Gly Ile Pro Lys Tyr Asn Ile Pro Ala Leu Lys Ser Lys Leu Asp 
    370                 375                 380                 


Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr Gln His Asp 
385                 390                 395                 400 


Tyr Ile Asp Ser Ala Asp Ile Ile Gly Trp Thr Arg Glu Gly Val Ala 
                405                 410                 415     


Glu Lys Ala Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly Pro Gly 
            420                 425                 430         


Gly Ser Lys Trp Met Tyr Val Gly Lys Gln His Ala Gly Lys Thr Phe 
        435                 440                 445             


Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile Asn Ala Asp 
    450                 455                 460                 


Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser Ile Trp Val 
465                 470                 475                 480 


Pro Lys 
        


<210>  18
<211>  484
<212>  PRT
<213>  Artififical Sequence

<400>  18

Gly Ser Val Pro Val Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr 
1               5                   10                  15      


Leu Pro Asp Asp Gly Thr Leu Trp Thr Lys Val Ala Asn Asn Ala Gln 
            20                  25                  30          


Ser Leu Ala Asn Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Ser Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Thr Gln Tyr Ile Gln Ala Ile Gln Ala Ala His Thr Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Lys Ala Gly Ala Asp 
            100                 105                 110         


Tyr Thr Glu Asn Val Thr Ala Val Glu Val Asn Pro Ser Asn Arg Asn 
        115                 120                 125             


Gln Glu Thr Ser Gly Glu Tyr Asn Ile Gln Ala Trp Thr Gly Phe Asn 
    130                 135                 140                 


Phe Pro Gly Arg Gly Thr Thr Tyr Ser Asn Phe Lys Trp Gln Trp Phe 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Gln Ser Arg Ser Leu Ser Arg Ile 
                165                 170                 175     


Phe Lys Phe Arg Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Ser Ser 
            180                 185                 190         


Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Ile Asp Met Asp 
        195                 200                 205             


His Pro Glu Val Val Ser Glu Leu Lys Asn Trp Gly Lys Trp Tyr Val 
    210                 215                 220                 


Thr Thr Thr Asn Ile Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile 
225                 230                 235                 240 


Lys Tyr Ser Phe Phe Pro Asp Trp Leu Ser Tyr Val Arg Thr Gln Thr 
                245                 250                 255     


Gln Lys Pro Leu Phe Ala Val Gly Glu Phe Trp Ser Tyr Asp Ile Ser 
            260                 265                 270         


Lys Leu His Asn Tyr Ile Thr Lys Thr Asn Gly Ser Met Ser Leu Phe 
        275                 280                 285             


Asp Ala Pro Leu His Asn Asn Phe Tyr Ile Ala Ser Lys Ser Gly Gly 
    290                 295                 300                 


Tyr Phe Asp Met Arg Thr Leu Leu Asn Asn Thr Leu Met Lys Asp Gln 
305                 310                 315                 320 


Pro Thr Leu Ala Val Thr Leu Val Asp Asn His Asp Thr Glu Pro Gly 
                325                 330                 335     


Gln Ser Leu Gln Ser Trp Val Glu Pro Trp Phe Lys Pro Leu Ala Tyr 
            340                 345                 350         


Ala Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr Gly 
        355                 360                 365             


Asp Tyr Tyr Gly Ile Pro Lys Tyr Asn Ile Pro Ala Leu Lys Ser Lys 
    370                 375                 380                 


Leu Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr Gln 
385                 390                 395                 400 


His Asp Tyr Ile Asp Ser Ala Asp Ile Ile Gly Trp Thr Arg Glu Gly 
                405                 410                 415     


Val Ala Glu Lys Ala Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly 
            420                 425                 430         


Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Gln His Ala Gly Lys 
        435                 440                 445             


Thr Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile Asn 
    450                 455                 460                 


Ala Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser Ile 
465                 470                 475                 480 


Trp Val Pro Lys 
                


<210>  19
<211>  484
<212>  PRT
<213>  Artifical Sequencce

<400>  19

Gly Ser Val Pro Val Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr 
1               5                   10                  15      


Leu Pro Asp Asp Gly Thr Leu Trp Thr Lys Val Ala Asn Asn Ala Gln 
            20                  25                  30          


Ser Leu Ala Asn Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Ser Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Thr Gln Tyr Ile Gln Ala Ile Gln Ala Ala His Thr Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asp His Lys Gly Gly Ala Asp 
            100                 105                 110         


Gly Thr Glu Trp Val Asp Ala Val Glu Val Asn Pro Ser Asp Arg Asn 
        115                 120                 125             


Gln Glu Ile Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Val Asp Trp Asp Glu Ser Arg Lys Leu Ser Arg Ile 
                165                 170                 175     


Tyr Lys Phe Arg Gly Ile Gly Lys Ala Trp Asp Trp Glu Val Asp Thr 
            180                 185                 190         


Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Leu Asp Met Asp 
        195                 200                 205             


His Pro Glu Val Val Ser Glu Leu Lys Asn Trp Gly Lys Trp Tyr Val 
    210                 215                 220                 


Thr Thr Thr Asn Ile Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile 
225                 230                 235                 240 


Lys Tyr Ser Phe Phe Pro Asp Trp Leu Ser Tyr Val Arg Thr Gln Thr 
                245                 250                 255     


Gln Lys Pro Leu Phe Ala Val Gly Glu Phe Trp Ser Tyr Asp Ile Ser 
            260                 265                 270         


Lys Leu His Asn Tyr Ile Thr Lys Thr Asn Gly Ser Met Ser Leu Phe 
        275                 280                 285             


Asp Ala Pro Leu His Asn Asn Phe Tyr Ile Ala Ser Lys Ser Gly Gly 
    290                 295                 300                 


Tyr Phe Asp Met Arg Thr Leu Leu Asn Asn Thr Leu Met Lys Asp Gln 
305                 310                 315                 320 


Pro Thr Leu Ala Val Thr Leu Val Asp Asn His Asp Thr Glu Pro Gly 
                325                 330                 335     


Gln Ser Leu Gln Ser Trp Val Glu Pro Trp Phe Lys Pro Leu Ala Tyr 
            340                 345                 350         


Ala Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr Gly 
        355                 360                 365             


Asp Tyr Tyr Gly Ile Pro Lys Tyr Asn Ile Pro Ala Leu Lys Ser Lys 
    370                 375                 380                 


Leu Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr Gln 
385                 390                 395                 400 


His Asp Tyr Ile Asp Ser Ala Asp Ile Ile Gly Trp Thr Arg Glu Gly 
                405                 410                 415     


Val Ala Glu Lys Ala Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly 
            420                 425                 430         


Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Gln His Ala Gly Lys 
        435                 440                 445             


Thr Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile Asn 
    450                 455                 460                 


Ala Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser Ile 
465                 470                 475                 480 


Trp Val Pro Lys 
                


<210>  20
<211>  484
<212>  PRT
<213>  Artiffical Sequence

<400>  20

Gly Ser Val Pro Val Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr 
1               5                   10                  15      


Leu Pro Asp Asp Gly Thr Leu Trp Thr Lys Val Ala Asn Asn Ala Gln 
            20                  25                  30          


Ser Leu Ala Asn Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Ser Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Thr Gln Tyr Ile Gln Ala Ile Gln Ala Ala His Thr Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Lys Ala Gly Ala Asp 
            100                 105                 110         


Gly Thr Glu Phe Val Asp Ala Val Glu Val Asn Pro Ser Asn Arg Asn 
        115                 120                 125             


Gln Glu Thr Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Glu Ser Arg Lys Leu Asn Arg Val 
                165                 170                 175     


Tyr Lys Phe Arg Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Asp Thr 
            180                 185                 190         


Glu Asn Gly Asn Tyr Asp Tyr Leu Met Phe Ala Asp Leu Asp Met Asp 
        195                 200                 205             


His Pro Glu Val Val Ser Glu Leu Lys Asn Trp Gly Lys Trp Tyr Val 
    210                 215                 220                 


Thr Thr Thr Asn Ile Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile 
225                 230                 235                 240 


Lys Tyr Ser Phe Phe Pro Asp Trp Leu Ser Tyr Val Arg Thr Gln Thr 
                245                 250                 255     


Gln Lys Pro Leu Phe Ala Val Gly Glu Phe Trp Ser Tyr Asp Ile Ser 
            260                 265                 270         


Lys Leu His Asn Tyr Ile Thr Lys Thr Asn Gly Ser Met Ser Leu Phe 
        275                 280                 285             


Asp Ala Pro Leu His Asn Asn Phe Tyr Ile Ala Ser Lys Ser Gly Gly 
    290                 295                 300                 


Tyr Phe Asp Met Arg Thr Leu Leu Asn Asn Thr Leu Met Lys Asp Gln 
305                 310                 315                 320 


Pro Thr Leu Ala Val Thr Leu Val Asp Asn His Asp Thr Glu Pro Gly 
                325                 330                 335     


Gln Ser Leu Gln Ser Trp Val Glu Pro Trp Phe Lys Pro Leu Ala Tyr 
            340                 345                 350         


Ala Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr Gly 
        355                 360                 365             


Asp Tyr Tyr Gly Ile Pro Lys Tyr Asn Ile Pro Ala Leu Lys Ser Lys 
    370                 375                 380                 


Leu Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr Gln 
385                 390                 395                 400 


His Asp Tyr Ile Asp Ser Ala Asp Ile Ile Gly Trp Thr Arg Glu Gly 
                405                 410                 415     


Val Ala Glu Lys Ala Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly 
            420                 425                 430         


Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Gln His Ala Gly Lys 
        435                 440                 445             


Thr Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile Asn 
    450                 455                 460                 


Ala Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser Ile 
465                 470                 475                 480 


Trp Val Pro Lys 
                


<210>  21
<211>  483
<212>  PRT
<213>  Artifical Sequence

<400>  21

Gly Ser Val Pro Val Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr 
1               5                   10                  15      


Leu Pro Asp Asp Gly Thr Leu Trp Thr Lys Val Ala Asn Asn Ala Gln 
            20                  25                  30          


Ser Leu Ala Asn Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Ser Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Thr Gln Tyr Ile Gln Ala Ile Gln Ala Ala His Thr Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Lys Ala Gly Ala Asp 
            100                 105                 110         


Gly Thr Glu Phe Val Asp Ala Val Glu Val Asp Pro Ser Asn Arg Asn 
        115                 120                 125             


Gln Glu Thr Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Glu Ser Arg Lys Leu Asn Arg Ile 
                165                 170                 175     


Tyr Lys Phe Ser Thr Gly Lys Ala Trp Asp Trp Glu Val Asp Thr Glu 
            180                 185                 190         


Asn Gly Asn Tyr Asp Tyr Leu Met Phe Ala Asp Leu Asp Met Asp His 
        195                 200                 205             


Pro Glu Val Val Ser Glu Leu Lys Asn Trp Gly Lys Trp Tyr Val Thr 
    210                 215                 220                 


Thr Thr Asn Ile Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile Lys 
225                 230                 235                 240 


Tyr Ser Phe Phe Pro Asp Trp Leu Ser Tyr Val Arg Thr Gln Thr Gln 
                245                 250                 255     


Lys Pro Leu Phe Ala Val Gly Glu Phe Trp Ser Tyr Asp Ile Ser Lys 
            260                 265                 270         


Leu His Asn Tyr Ile Thr Lys Thr Asn Gly Ser Met Ser Leu Phe Asp 
        275                 280                 285             


Ala Pro Leu His Asn Asn Phe Tyr Ile Ala Ser Lys Ser Gly Gly Tyr 
    290                 295                 300                 


Phe Asp Met Arg Thr Leu Leu Asn Asn Thr Leu Met Lys Asp Gln Pro 
305                 310                 315                 320 


Thr Leu Ala Val Thr Leu Val Asp Asn His Asp Thr Glu Pro Gly Gln 
                325                 330                 335     


Ser Leu Gln Ser Trp Val Glu Pro Trp Phe Lys Pro Leu Ala Tyr Ala 
            340                 345                 350         


Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr Gly Asp 
        355                 360                 365             


Tyr Tyr Gly Ile Pro Lys Tyr Asn Ile Pro Ala Leu Lys Ser Lys Leu 
    370                 375                 380                 


Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr Gln His 
385                 390                 395                 400 


Asp Tyr Ile Asp Ser Ala Asp Ile Ile Gly Trp Thr Arg Glu Gly Val 
                405                 410                 415     


Ala Glu Lys Ala Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly Pro 
            420                 425                 430         


Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Gln His Ala Gly Lys Thr 
        435                 440                 445             


Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile Asn Ala 
    450                 455                 460                 


Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser Ile Trp 
465                 470                 475                 480 


Val Pro Lys 
            


<210>  22
<211>  484
<212>  PRT
<213>  Artifical Sequence

<400>  22

Gly Ser Val Pro Val Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr 
1               5                   10                  15      


Leu Pro Asp Asp Gly Thr Leu Trp Thr Lys Val Ala Asn Asn Ala Gln 
            20                  25                  30          


Ser Leu Ala Asn Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Ser Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Thr Gln Tyr Ile Gln Ala Ile Gln Ala Ala His Thr Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Lys Ala Gly Ala Asp 
            100                 105                 110         


Gly Thr Glu Phe Val Asp Ala Val Glu Val Asn Pro Ser Asn Arg Asn 
        115                 120                 125             


Gln Glu Thr Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Glu Ser Arg Lys Leu Asn Arg Ile 
                165                 170                 175     


Tyr Lys Phe Arg Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Asp Thr 
            180                 185                 190         


Glu Asn Gly Asn Tyr Asp Tyr Leu Met Phe Ala Asp Leu Asp Met Asp 
        195                 200                 205             


His Pro Glu Val Val Ser Glu Leu Lys Asn Trp Gly Lys Trp Tyr Val 
    210                 215                 220                 


Thr Thr Thr Asn Ile Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile 
225                 230                 235                 240 


Lys Tyr Ser Phe Phe Pro Asp Trp Leu Ser Tyr Val Arg Thr Gln Thr 
                245                 250                 255     


Gln Lys Pro Leu Phe Ala Val Gly Glu Phe Trp Ser Tyr Asp Ile Ser 
            260                 265                 270         


Lys Leu His Asn Tyr Ile Thr Lys Thr Asn Gly Ser Met Ser Leu Phe 
        275                 280                 285             


Asp Ala Pro Leu His Asn Asn Phe Tyr Ile Ala Ser Lys Ser Gly Gly 
    290                 295                 300                 


Tyr Phe Asp Met Arg Thr Leu Leu Asn Asn Thr Leu Met Lys Asp Gln 
305                 310                 315                 320 


Pro Thr Leu Ala Val Thr Leu Val Asp Asn His Asp Thr Glu Pro Gly 
                325                 330                 335     


Gln Ser Leu Gln Ser Trp Val Glu Pro Trp Phe Lys Pro Leu Ala Tyr 
            340                 345                 350         


Ala Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr Gly 
        355                 360                 365             


Asp Tyr Tyr Gly Ile Pro Lys Tyr Asn Ile Pro Ala Leu Lys Ser Lys 
    370                 375                 380                 


Leu Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr Gln 
385                 390                 395                 400 


His Asp Tyr Ile Asp Ser Ala Asp Ile Ile Gly Trp Thr Arg Glu Gly 
                405                 410                 415     


Val Ala Glu Lys Ala Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly 
            420                 425                 430         


Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Gln His Ala Gly Lys 
        435                 440                 445             


Thr Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile Asn 
    450                 455                 460                 


Ala Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser Ile 
465                 470                 475                 480 


Trp Val Pro Lys 
                


<210>  23
<211>  484
<212>  PRT
<213>  Artifical Sequence

<400>  23

Gly Ser Val Pro Val Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr 
1               5                   10                  15      


Leu Pro Asp Asp Gly Thr Leu Trp Thr Lys Val Ala Asn Asn Ala Gln 
            20                  25                  30          


Ser Leu Ala Asn Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Ser Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Thr Gln Tyr Ile Gln Ala Ile Gln Ala Ala His Thr Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Lys Ala Gly Ala Asp 
            100                 105                 110         


Ala Thr Glu Trp Val Asp Ala Val Glu Val Asn Pro Ser Asn Arg Asn 
        115                 120                 125             


Gln Glu Val Ser Gly Thr Tyr Lys Ile Gln Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Gln Ser Arg Gln Leu Asn Arg Ile 
                165                 170                 175     


Tyr Lys Phe Arg Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Asp Thr 
            180                 185                 190         


Glu Asn Gly Asn Tyr Asp Tyr Leu Met Phe Ala Asp Leu Asp Met Asp 
        195                 200                 205             


His Pro Glu Val Val Ser Glu Leu Lys Asn Trp Gly Lys Trp Tyr Val 
    210                 215                 220                 


Thr Thr Thr Asn Ile Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile 
225                 230                 235                 240 


Lys Tyr Ser Phe Phe Pro Asp Trp Leu Ser Tyr Val Arg Thr Gln Thr 
                245                 250                 255     


Gln Lys Pro Leu Phe Ala Val Gly Glu Phe Trp Ser Tyr Asp Ile Ser 
            260                 265                 270         


Lys Leu His Asn Tyr Ile Thr Lys Thr Asn Gly Ser Met Ser Leu Phe 
        275                 280                 285             


Asp Ala Pro Leu His Asn Asn Phe Tyr Ile Ala Ser Lys Ser Gly Gly 
    290                 295                 300                 


Tyr Phe Asp Met Arg Thr Leu Leu Asn Asn Thr Leu Met Lys Asp Gln 
305                 310                 315                 320 


Pro Thr Leu Ala Val Thr Leu Val Asp Asn His Asp Thr Glu Pro Gly 
                325                 330                 335     


Gln Ser Leu Gln Ser Trp Val Glu Pro Trp Phe Lys Pro Leu Ala Tyr 
            340                 345                 350         


Ala Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr Gly 
        355                 360                 365             


Asp Tyr Tyr Gly Ile Pro Lys Tyr Asn Ile Pro Ala Leu Lys Ser Lys 
    370                 375                 380                 


Leu Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr Gln 
385                 390                 395                 400 


His Asp Tyr Ile Asp Ser Ala Asp Ile Ile Gly Trp Thr Arg Glu Gly 
                405                 410                 415     


Val Ala Glu Lys Ala Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly 
            420                 425                 430         


Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Gln His Ala Gly Lys 
        435                 440                 445             


Thr Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile Asn 
    450                 455                 460                 


Ala Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser Ile 
465                 470                 475                 480 


Trp Val Pro Lys 
                


<210>  24
<211>  484
<212>  PRT
<213>  Artifical Sequence

<400>  24

Gly Ser Val Pro Val Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr 
1               5                   10                  15      


Leu Pro Asp Asp Gly Thr Leu Trp Thr Lys Val Ala Asn Asn Ala Gln 
            20                  25                  30          


Ser Leu Ala Asn Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Ser Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Thr Gln Tyr Ile Gln Ala Ile Gln Ala Ala His Thr Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Lys Ala Gly Ala Asp 
            100                 105                 110         


Ser Thr Glu Trp Val Asp Ala Val Glu Val Asn Pro Ser Asn Arg Asn 
        115                 120                 125             


Gln Glu Thr Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Glu Ser Arg Lys Leu Asn Arg Ile 
                165                 170                 175     


Tyr Lys Phe Arg Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Asp Thr 
            180                 185                 190         


Glu Asn Gly Asn Tyr Asp Tyr Leu Met Phe Ala Asp Leu Asp Met Asp 
        195                 200                 205             


His Pro Glu Val Val Ser Glu Leu Lys Asn Trp Gly Lys Trp Tyr Val 
    210                 215                 220                 


Thr Thr Thr Asn Ile Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile 
225                 230                 235                 240 


Lys Tyr Ser Phe Phe Pro Asp Trp Leu Ser Tyr Val Arg Thr Gln Thr 
                245                 250                 255     


Gln Lys Pro Leu Phe Ala Val Gly Glu Phe Trp Ser Tyr Asp Ile Ser 
            260                 265                 270         


Lys Leu His Asn Tyr Ile Thr Lys Thr Asn Gly Ser Met Ser Leu Phe 
        275                 280                 285             


Asp Ala Pro Leu His Asn Asn Phe Tyr Ile Ala Ser Lys Ser Gly Gly 
    290                 295                 300                 


Tyr Phe Asp Met Arg Thr Leu Leu Asn Asn Thr Leu Met Lys Asp Gln 
305                 310                 315                 320 


Pro Thr Leu Ala Val Thr Leu Val Asp Asn His Asp Thr Glu Pro Gly 
                325                 330                 335     


Gln Ser Leu Gln Ser Trp Val Glu Pro Trp Phe Lys Pro Leu Ala Tyr 
            340                 345                 350         


Ala Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr Gly 
        355                 360                 365             


Asp Tyr Tyr Gly Ile Pro Lys Tyr Asn Ile Pro Ala Leu Lys Ser Lys 
    370                 375                 380                 


Leu Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr Gln 
385                 390                 395                 400 


His Asp Tyr Ile Asp Ser Ala Asp Ile Ile Gly Trp Thr Arg Glu Gly 
                405                 410                 415     


Val Ala Glu Lys Ala Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly 
            420                 425                 430         


Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Gln His Ala Gly Lys 
        435                 440                 445             


Thr Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile Asn 
    450                 455                 460                 


Ala Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser Ile 
465                 470                 475                 480 


Trp Val Pro Lys 
                


<210>  25
<211>  485
<212>  PRT
<213>  Artifical Sequence

<400>  25

Gly Ser Val Pro Val Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr 
1               5                   10                  15      


Leu Pro Asp Asp Gly Thr Leu Trp Thr Lys Val Ala Asn Asn Ala Gln 
            20                  25                  30          


Ser Leu Ala Asn Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Ser Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Thr Gln Tyr Ile Gln Ala Ile Gln Ala Ala His Thr Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Lys Gly Gly Ala Asp 
            100                 105                 110         


Phe Thr Glu Arg Val Gln Ala Val Glu Val Asn Pro Gln Asn Arg Asn 
        115                 120                 125             


Gln Glu Val Ser Gly Thr Tyr Gln Ile Glu Ala Trp Thr Gly Phe Asn 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Gln His Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Gln Ser Arg Gln Leu Ala Asn Arg 
                165                 170                 175     


Ile Tyr Lys Phe Arg Gly Asp Gly Lys Ala Trp Asp Trp Glu Val Asp 
            180                 185                 190         


Thr Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Val Asp Met 
        195                 200                 205             


Asp His Pro Glu Val Val Ser Glu Leu Lys Asn Trp Gly Lys Trp Tyr 
    210                 215                 220                 


Val Thr Thr Thr Asn Ile Asp Gly Phe Arg Leu Asp Ala Val Lys His 
225                 230                 235                 240 


Ile Lys Tyr Ser Phe Phe Pro Asp Trp Leu Ser Tyr Val Arg Thr Gln 
                245                 250                 255     


Thr Gln Lys Pro Leu Phe Ala Val Gly Glu Phe Trp Ser Tyr Asp Ile 
            260                 265                 270         


Ser Lys Leu His Asn Tyr Ile Thr Lys Thr Asn Gly Ser Met Ser Leu 
        275                 280                 285             


Phe Asp Ala Pro Leu His Asn Asn Phe Tyr Ile Ala Ser Lys Ser Gly 
    290                 295                 300                 


Gly Tyr Phe Asp Met Arg Thr Leu Leu Asn Asn Thr Leu Met Lys Asp 
305                 310                 315                 320 


Gln Pro Thr Leu Ala Val Thr Leu Val Asp Asn His Asp Thr Glu Pro 
                325                 330                 335     


Gly Gln Ser Leu Gln Ser Trp Val Glu Pro Trp Phe Lys Pro Leu Ala 
            340                 345                 350         


Tyr Ala Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr 
        355                 360                 365             


Gly Asp Tyr Tyr Gly Ile Pro Lys Tyr Asn Ile Pro Ala Leu Lys Ser 
    370                 375                 380                 


Lys Leu Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr 
385                 390                 395                 400 


Gln His Asp Tyr Ile Asp Ser Ala Asp Ile Ile Gly Trp Thr Arg Glu 
                405                 410                 415     


Gly Val Ala Glu Lys Ala Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp 
            420                 425                 430         


Gly Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Gln His Ala Gly 
        435                 440                 445             


Lys Thr Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile 
    450                 455                 460                 


Asn Ala Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser 
465                 470                 475                 480 


Ile Trp Val Pro Lys 
                485 


<210>  26
<211>  485
<212>  PRT
<213>  Artifical Sequnce

<400>  26

Gly Ser Val Pro Val Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr 
1               5                   10                  15      


Leu Pro Asp Asp Gly Thr Leu Trp Thr Lys Val Ala Asn Asn Ala Gln 
            20                  25                  30          


Ser Leu Ala Asn Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Ser Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Thr Gln Tyr Ile Gln Ala Ile Gln Ala Ala His Thr Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Lys Gly Gly Ala Asp 
            100                 105                 110         


Ala Thr Glu Asn Val Leu Ala Val Glu Val Asn Pro Asn Asn Arg Asn 
        115                 120                 125             


Gln Glu Ile Ser Gly Asp Tyr Thr Ile Glu Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Asp Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Val Asp Trp Asp Gln Ser Arg Gln Phe Gln Asn Arg 
                165                 170                 175     


Ile Tyr Lys Phe Arg Gly Asp Gly Lys Ala Trp Asp Trp Glu Val Asp 
            180                 185                 190         


Ser Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Val Asp Met 
        195                 200                 205             


Asp His Pro Glu Val Val Ser Glu Leu Lys Asn Trp Gly Lys Trp Tyr 
    210                 215                 220                 


Val Thr Thr Thr Asn Ile Asp Gly Phe Arg Leu Asp Ala Val Lys His 
225                 230                 235                 240 


Ile Lys Tyr Ser Phe Phe Pro Asp Trp Leu Ser Tyr Val Arg Thr Gln 
                245                 250                 255     


Thr Gln Lys Pro Leu Phe Ala Val Gly Glu Phe Trp Ser Tyr Asp Ile 
            260                 265                 270         


Ser Lys Leu His Asn Tyr Ile Thr Lys Thr Asn Gly Ser Met Ser Leu 
        275                 280                 285             


Phe Asp Ala Pro Leu His Asn Asn Phe Tyr Ile Ala Ser Lys Ser Gly 
    290                 295                 300                 


Gly Tyr Phe Asp Met Arg Thr Leu Leu Asn Asn Thr Leu Met Lys Asp 
305                 310                 315                 320 


Gln Pro Thr Leu Ala Val Thr Leu Val Asp Asn His Asp Thr Glu Pro 
                325                 330                 335     


Gly Gln Ser Leu Gln Ser Trp Val Glu Pro Trp Phe Lys Pro Leu Ala 
            340                 345                 350         


Tyr Ala Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr 
        355                 360                 365             


Gly Asp Tyr Tyr Gly Ile Pro Lys Tyr Asn Ile Pro Ala Leu Lys Ser 
    370                 375                 380                 


Lys Leu Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr 
385                 390                 395                 400 


Gln His Asp Tyr Ile Asp Ser Ala Asp Ile Ile Gly Trp Thr Arg Glu 
                405                 410                 415     


Gly Val Ala Glu Lys Ala Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp 
            420                 425                 430         


Gly Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Gln His Ala Gly 
        435                 440                 445             


Lys Thr Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile 
    450                 455                 460                 


Asn Ala Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser 
465                 470                 475                 480 


Ile Trp Val Pro Lys 
                485 


<210>  27
<211>  485
<212>  PRT
<213>  Artifical Sequence

<400>  27

Gly Ser Val Pro Val Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr 
1               5                   10                  15      


Leu Pro Asp Asp Gly Thr Leu Trp Thr Lys Val Ala Asn Asn Ala Gln 
            20                  25                  30          


Ser Leu Ala Asn Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Ser Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Thr Gln Tyr Ile Gln Ala Ile Gln Ala Ala His Thr Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Lys Gly Gly Ala Asp 
            100                 105                 110         


Ala Thr Glu Met Val Arg Ala Val Glu Val Asn Pro Asn Asn Arg Asn 
        115                 120                 125             


Gln Glu Val Ser Gly Glu Tyr Thr Ile Glu Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr His Ser Asn Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Val Asp Trp Asp Gln Ser Arg Lys Leu Asn Asn Arg 
                165                 170                 175     


Ile Tyr Lys Phe Arg Gly Asp Gly Lys Gly Trp Asp Trp Glu Val Asp 
            180                 185                 190         


Thr Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Ile Asp Met 
        195                 200                 205             


Asp His Pro Glu Val Val Ser Glu Leu Lys Asn Trp Gly Lys Trp Tyr 
    210                 215                 220                 


Val Thr Thr Thr Asn Ile Asp Gly Phe Arg Leu Asp Ala Val Lys His 
225                 230                 235                 240 


Ile Lys Tyr Ser Phe Phe Pro Asp Trp Leu Ser Tyr Val Arg Thr Gln 
                245                 250                 255     


Thr Gln Lys Pro Leu Phe Ala Val Gly Glu Phe Trp Ser Tyr Asp Ile 
            260                 265                 270         


Ser Lys Leu His Asn Tyr Ile Thr Lys Thr Asn Gly Ser Met Ser Leu 
        275                 280                 285             


Phe Asp Ala Pro Leu His Asn Asn Phe Tyr Ile Ala Ser Lys Ser Gly 
    290                 295                 300                 


Gly Tyr Phe Asp Met Arg Thr Leu Leu Asn Asn Thr Leu Met Lys Asp 
305                 310                 315                 320 


Gln Pro Thr Leu Ala Val Thr Leu Val Asp Asn His Asp Thr Glu Pro 
                325                 330                 335     


Gly Gln Ser Leu Gln Ser Trp Val Glu Pro Trp Phe Lys Pro Leu Ala 
            340                 345                 350         


Tyr Ala Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr 
        355                 360                 365             


Gly Asp Tyr Tyr Gly Ile Pro Lys Tyr Asn Ile Pro Ala Leu Lys Ser 
    370                 375                 380                 


Lys Leu Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr 
385                 390                 395                 400 


Gln His Asp Tyr Ile Asp Ser Ala Asp Ile Ile Gly Trp Thr Arg Glu 
                405                 410                 415     


Gly Val Ala Glu Lys Ala Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp 
            420                 425                 430         


Gly Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Gln His Ala Gly 
        435                 440                 445             


Lys Thr Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile 
    450                 455                 460                 


Asn Ala Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser 
465                 470                 475                 480 


Ile Trp Val Pro Lys 
                485 


<210>  28
<211>  485
<212>  PRT
<213>  Artifiical Sequence

<400>  28

Gly Ser Val Pro Val Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr 
1               5                   10                  15      


Leu Pro Asp Asp Gly Thr Leu Trp Thr Lys Val Ala Asn Asn Ala Gln 
            20                  25                  30          


Ser Leu Ala Asn Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Ser Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Thr Gln Tyr Ile Gln Ala Ile Gln Ala Ala His Thr Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Lys Gly Gly Ala Asp 
            100                 105                 110         


Ala Thr Glu Met Val Arg Ala Val Glu Val Asn Pro Asn Asn Arg Asn 
        115                 120                 125             


Gln Glu Val Thr Gly Glu Tyr Thr Ile Glu Ala Trp Thr Arg Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr His Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Val Asp Trp Asp Gln Ser Arg Arg Leu Asn Asn Arg 
                165                 170                 175     


Ile Tyr Lys Phe Arg Gly His Gly Lys Ala Trp Asp Trp Glu Val Asp 
            180                 185                 190         


Thr Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Ile Asp Met 
        195                 200                 205             


Asp His Pro Glu Val Val Ser Glu Leu Lys Asn Trp Gly Lys Trp Tyr 
    210                 215                 220                 


Val Thr Thr Thr Asn Ile Asp Gly Phe Arg Leu Asp Ala Val Lys His 
225                 230                 235                 240 


Ile Lys Tyr Ser Phe Phe Pro Asp Trp Leu Ser Tyr Val Arg Thr Gln 
                245                 250                 255     


Thr Gln Lys Pro Leu Phe Ala Val Gly Glu Phe Trp Ser Tyr Asp Ile 
            260                 265                 270         


Ser Lys Leu His Asn Tyr Ile Thr Lys Thr Asn Gly Ser Met Ser Leu 
        275                 280                 285             


Phe Asp Ala Pro Leu His Asn Asn Phe Tyr Ile Ala Ser Lys Ser Gly 
    290                 295                 300                 


Gly Tyr Phe Asp Met Arg Thr Leu Leu Asn Asn Thr Leu Met Lys Asp 
305                 310                 315                 320 


Gln Pro Thr Leu Ala Val Thr Leu Val Asp Asn His Asp Thr Glu Pro 
                325                 330                 335     


Gly Gln Ser Leu Gln Ser Trp Val Glu Pro Trp Phe Lys Pro Leu Ala 
            340                 345                 350         


Tyr Ala Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr 
        355                 360                 365             


Gly Asp Tyr Tyr Gly Ile Pro Lys Tyr Asn Ile Pro Ala Leu Lys Ser 
    370                 375                 380                 


Lys Leu Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr 
385                 390                 395                 400 


Gln His Asp Tyr Ile Asp Ser Ala Asp Ile Ile Gly Trp Thr Arg Glu 
                405                 410                 415     


Gly Val Ala Glu Lys Ala Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp 
            420                 425                 430         


Gly Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Gln His Ala Gly 
        435                 440                 445             


Lys Thr Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile 
    450                 455                 460                 


Asn Ala Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser 
465                 470                 475                 480 


Ile Trp Val Pro Lys 
                485 


<210>  29
<211>  485
<212>  PRT
<213>  Artifical Sequence

<400>  29

Asn Thr Ala Pro Val Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Asp 
1               5                   10                  15      


Leu Pro Asn Asp Gly Thr Leu Trp Thr Lys Val Lys Asn Glu Ala Ala 
            20                  25                  30          


Asn Leu Ser Ser Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Gln Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Asp Gln Tyr Ile Gln Ala Ile Gln Ala Ala Lys Ala Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Arg Met Gly Ala Asp 
            100                 105                 110         


Ala Thr Glu Thr Ile Ser Ala Val Glu Val Asn Pro Ser Asn Arg Asn 
        115                 120                 125             


Gln Val Thr Ser Gly Ala Tyr Asn Ile Ser Ala Trp Thr Asp Phe Glu 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp His Ser Tyr 
145                 150                 155                 160 


Tyr Phe Asp Gly Val Asp Trp Asp Gln Ser Arg Gln Leu Ser Gly Lys 
                165                 170                 175     


Ile Tyr Gln Ile Gln Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Asp 
            180                 185                 190         


Ser Glu Asn Gly Asn Tyr Asp Tyr Leu Met Gly Ala Asp Ile Asp Met 
        195                 200                 205             


Asp His Pro Glu Val Val Thr Glu Leu Lys Asn Trp Gly Lys Trp Tyr 
    210                 215                 220                 


Val Asn Thr Thr Asn Val Asp Gly Phe Arg Leu Asp Ala Val Lys His 
225                 230                 235                 240 


Ile Lys Tyr Ser Phe Phe Pro Asp Trp Leu Ala Ser Val Arg Ser Gln 
                245                 250                 255     


Thr Gly Lys Asn Leu Phe Ala Val Gly Glu Phe Trp Ser Tyr Asp Val 
            260                 265                 270         


Asn Lys Leu His Asn Tyr Ile Thr Lys Thr Asn Gly Thr Met Ser Leu 
        275                 280                 285             


Phe Asp Ala Pro Leu His Asn Asn Phe Tyr Thr Ala Ser Lys Ser Ser 
    290                 295                 300                 


Gly Tyr Phe Asp Met Arg Tyr Leu Leu Asn Asn Thr Leu Met Lys Asp 
305                 310                 315                 320 


Gln Pro Val Leu Ala Val Thr Leu Val Asp Asn His Asp Thr Gln Pro 
                325                 330                 335     


Gly Gln Ser Leu Gln Ser Trp Val Glu Pro Trp Phe Lys Pro Leu Ala 
            340                 345                 350         


Tyr Ala Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr 
        355                 360                 365             


Gly Asp Tyr Tyr Gly Ile Pro Lys Tyr Asn Ile Pro Gly Leu Lys Ser 
    370                 375                 380                 


Lys Ile Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr 
385                 390                 395                 400 


Gln Arg Asp Tyr Ile Asp His Gln Asp Ile Ile Gly Trp Thr Arg Glu 
                405                 410                 415     


Gly Ile Asp Ser Lys Pro Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp 
            420                 425                 430         


Gly Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Lys His Ala Gly 
        435                 440                 445             


Lys Val Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile 
    450                 455                 460                 


Asn Ala Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser 
465                 470                 475                 480 


Ile Trp Val Ala Lys 
                485 


<210>  30
<211>  484
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  30

Asn Thr Ala Pro Val Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Asp 
1               5                   10                  15      


Leu Pro Asn Asp Gly Thr Leu Trp Thr Lys Val Lys Asn Glu Ala Ala 
            20                  25                  30          


Asn Leu Ser Ser Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Gln Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Asp Gln Tyr Ile Gln Ala Ile Gln Ala Ala Lys Ala Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Lys Ala Gly Ala Asp 
            100                 105                 110         


Ala Thr Glu Asp Val Thr Ala Val Glu Val Asn Pro Ala Asn Arg Asn 
        115                 120                 125             


Gln Glu Thr Ser Glu Glu Tyr Gln Ile Lys Ala Trp Thr Asp Phe Arg 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Asp Phe Lys Trp His Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Ala Asp Trp Asp Glu Ser Arg Lys Ile Ser Arg Ile 
                165                 170                 175     


Phe Lys Phe Arg Gly Glu Gly Lys Ala Trp Asp Trp Glu Val Ser Ser 
            180                 185                 190         


Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Val Asp Met Asp 
        195                 200                 205             


His Pro Glu Val Val Thr Glu Leu Lys Asn Trp Gly Lys Trp Tyr Val 
    210                 215                 220                 


Asn Thr Thr Asn Val Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile 
225                 230                 235                 240 


Lys Tyr Ser Phe Phe Pro Asp Trp Leu Ala Ser Val Arg Ser Gln Thr 
                245                 250                 255     


Gly Lys Asn Leu Phe Ala Val Gly Glu Phe Trp Ser Tyr Asp Val Asn 
            260                 265                 270         


Lys Leu His Asn Tyr Ile Thr Lys Thr Asn Gly Thr Met Ser Leu Phe 
        275                 280                 285             


Asp Ala Pro Leu His Asn Asn Phe Tyr Thr Ala Ser Lys Ser Ser Gly 
    290                 295                 300                 


Tyr Phe Asp Met Arg Tyr Leu Leu Asn Asn Thr Leu Met Lys Asp Gln 
305                 310                 315                 320 


Pro Val Leu Ala Val Thr Leu Val Asp Asn His Asp Thr Gln Pro Gly 
                325                 330                 335     


Gln Ser Leu Gln Ser Trp Val Glu Pro Trp Phe Lys Pro Leu Ala Tyr 
            340                 345                 350         


Ala Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr Gly 
        355                 360                 365             


Asp Tyr Tyr Gly Ile Pro Lys Tyr Asn Ile Pro Gly Leu Lys Ser Lys 
    370                 375                 380                 


Ile Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr Gln 
385                 390                 395                 400 


Arg Asp Tyr Ile Asp His Gln Asp Ile Ile Gly Trp Thr Arg Glu Gly 
                405                 410                 415     


Ile Asp Ser Lys Pro Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly 
            420                 425                 430         


Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Lys His Ala Gly Lys 
        435                 440                 445             


Val Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile Asn 
    450                 455                 460                 


Ala Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser Ile 
465                 470                 475                 480 


Trp Val Ala Lys 
                


<210>  31
<211>  482
<212>  PRT
<213>  Artifiical Sequence

<400>  31

Asn Thr Ala Pro Val Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Asp 
1               5                   10                  15      


Leu Pro Asn Asp Gly Thr Leu Trp Thr Lys Val Lys Asn Glu Ala Ala 
            20                  25                  30          


Asn Leu Ser Ser Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Gln Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Asp Gln Tyr Ile Gln Ala Ile Gln Ala Ala Lys Ala Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Lys Gly Gly Ala Asp 
            100                 105                 110         


Ala Thr Glu Asp Val Thr Ala Val Glu Val Asp Pro Ala Asp Arg Asn 
        115                 120                 125             


Arg Val Ile Ser Gly Glu His Leu Ile Lys Ala Trp Thr His Phe His 
    130                 135                 140                 


Phe Pro Gly Arg Gly Ser Thr Tyr Ser Asp Phe Lys Trp His Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Glu Ser Arg Lys Leu Asn Arg Ile 
                165                 170                 175     


Tyr Lys Phe Gln Gly Lys Ala Trp Asp Trp Glu Val Ser Asn Glu Phe 
            180                 185                 190         


Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Ile Asp Met Asp His Pro 
        195                 200                 205             


Glu Val Val Thr Glu Leu Lys Asn Trp Gly Lys Trp Tyr Val Asn Thr 
    210                 215                 220                 


Thr Asn Val Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile Lys Tyr 
225                 230                 235                 240 


Ser Phe Phe Pro Asp Trp Leu Ala Ser Val Arg Ser Gln Thr Gly Lys 
                245                 250                 255     


Asn Leu Phe Ala Val Gly Glu Phe Trp Ser Tyr Asp Val Asn Lys Leu 
            260                 265                 270         


His Asn Tyr Ile Thr Lys Thr Asn Gly Thr Met Ser Leu Phe Asp Ala 
        275                 280                 285             


Pro Leu His Asn Asn Phe Tyr Thr Ala Ser Lys Ser Ser Gly Tyr Phe 
    290                 295                 300                 


Asp Met Arg Tyr Leu Leu Asn Asn Thr Leu Met Lys Asp Gln Pro Val 
305                 310                 315                 320 


Leu Ala Val Thr Leu Val Asp Asn His Asp Thr Gln Pro Gly Gln Ser 
                325                 330                 335     


Leu Gln Ser Trp Val Glu Pro Trp Phe Lys Pro Leu Ala Tyr Ala Phe 
            340                 345                 350         


Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr Gly Asp Tyr 
        355                 360                 365             


Tyr Gly Ile Pro Lys Tyr Asn Ile Pro Gly Leu Lys Ser Lys Ile Asp 
    370                 375                 380                 


Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr Gln Arg Asp 
385                 390                 395                 400 


Tyr Ile Asp His Gln Asp Ile Ile Gly Trp Thr Arg Glu Gly Ile Asp 
                405                 410                 415     


Ser Lys Pro Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly Pro Gly 
            420                 425                 430         


Gly Ser Lys Trp Met Tyr Val Gly Lys Lys His Ala Gly Lys Val Phe 
        435                 440                 445             


Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile Asn Ala Asp 
    450                 455                 460                 


Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser Ile Trp Val 
465                 470                 475                 480 


Ala Lys 
        


<210>  32
<211>  484
<212>  PRT
<213>  Artifiical Sequence

<400>  32

Asn Thr Ala Pro Val Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Asp 
1               5                   10                  15      


Leu Pro Asn Asp Gly Thr Leu Trp Thr Lys Val Lys Asn Glu Ala Ala 
            20                  25                  30          


Asn Leu Ser Ser Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Gln Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Asp Gln Tyr Ile Gln Ala Ile Gln Ala Ala Lys Ala Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Lys Ala Gly Ala Asp 
            100                 105                 110         


Tyr Thr Glu Asn Val Thr Ala Val Glu Val Asn Pro Ser Asn Arg Asn 
        115                 120                 125             


Gln Glu Thr Ser Gly Glu Tyr Asn Ile Gln Ala Trp Thr Gly Phe Asn 
    130                 135                 140                 


Phe Pro Gly Arg Gly Thr Thr Tyr Ser Asn Phe Lys Trp Gln Trp Phe 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Gln Ser Arg Ser Leu Ser Arg Ile 
                165                 170                 175     


Phe Lys Phe Arg Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Ser Ser 
            180                 185                 190         


Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Ile Asp Met Asp 
        195                 200                 205             


His Pro Glu Val Val Thr Glu Leu Lys Asn Trp Gly Lys Trp Tyr Val 
    210                 215                 220                 


Asn Thr Thr Asn Val Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile 
225                 230                 235                 240 


Lys Tyr Ser Phe Phe Pro Asp Trp Leu Ala Ser Val Arg Ser Gln Thr 
                245                 250                 255     


Gly Lys Asn Leu Phe Ala Val Gly Glu Phe Trp Ser Tyr Asp Val Asn 
            260                 265                 270         


Lys Leu His Asn Tyr Ile Thr Lys Thr Asn Gly Thr Met Ser Leu Phe 
        275                 280                 285             


Asp Ala Pro Leu His Asn Asn Phe Tyr Thr Ala Ser Lys Ser Ser Gly 
    290                 295                 300                 


Tyr Phe Asp Met Arg Tyr Leu Leu Asn Asn Thr Leu Met Lys Asp Gln 
305                 310                 315                 320 


Pro Val Leu Ala Val Thr Leu Val Asp Asn His Asp Thr Gln Pro Gly 
                325                 330                 335     


Gln Ser Leu Gln Ser Trp Val Glu Pro Trp Phe Lys Pro Leu Ala Tyr 
            340                 345                 350         


Ala Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr Gly 
        355                 360                 365             


Asp Tyr Tyr Gly Ile Pro Lys Tyr Asn Ile Pro Gly Leu Lys Ser Lys 
    370                 375                 380                 


Ile Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr Gln 
385                 390                 395                 400 


Arg Asp Tyr Ile Asp His Gln Asp Ile Ile Gly Trp Thr Arg Glu Gly 
                405                 410                 415     


Ile Asp Ser Lys Pro Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly 
            420                 425                 430         


Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Lys His Ala Gly Lys 
        435                 440                 445             


Val Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile Asn 
    450                 455                 460                 


Ala Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser Ile 
465                 470                 475                 480 


Trp Val Ala Lys 
                


<210>  33
<211>  484
<212>  PRT
<213>  Artifical Sequence

<400>  33

Asn Thr Ala Pro Val Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Asp 
1               5                   10                  15      


Leu Pro Asn Asp Gly Thr Leu Trp Thr Lys Val Lys Asn Glu Ala Ala 
            20                  25                  30          


Asn Leu Ser Ser Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Gln Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Asp Gln Tyr Ile Gln Ala Ile Gln Ala Ala Lys Ala Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asp His Lys Gly Gly Ala Asp 
            100                 105                 110         


Gly Thr Glu Trp Val Asp Ala Val Glu Val Asn Pro Ser Asp Arg Asn 
        115                 120                 125             


Gln Glu Ile Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Val Asp Trp Asp Glu Ser Arg Lys Leu Ser Arg Ile 
                165                 170                 175     


Tyr Lys Phe Arg Gly Ile Gly Lys Ala Trp Asp Trp Glu Val Asp Thr 
            180                 185                 190         


Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Leu Asp Met Asp 
        195                 200                 205             


His Pro Glu Val Val Thr Glu Leu Lys Asn Trp Gly Lys Trp Tyr Val 
    210                 215                 220                 


Asn Thr Thr Asn Val Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile 
225                 230                 235                 240 


Lys Tyr Ser Phe Phe Pro Asp Trp Leu Ala Ser Val Arg Ser Gln Thr 
                245                 250                 255     


Gly Lys Asn Leu Phe Ala Val Gly Glu Phe Trp Ser Tyr Asp Val Asn 
            260                 265                 270         


Lys Leu His Asn Tyr Ile Thr Lys Thr Asn Gly Thr Met Ser Leu Phe 
        275                 280                 285             


Asp Ala Pro Leu His Asn Asn Phe Tyr Thr Ala Ser Lys Ser Ser Gly 
    290                 295                 300                 


Tyr Phe Asp Met Arg Tyr Leu Leu Asn Asn Thr Leu Met Lys Asp Gln 
305                 310                 315                 320 


Pro Val Leu Ala Val Thr Leu Val Asp Asn His Asp Thr Gln Pro Gly 
                325                 330                 335     


Gln Ser Leu Gln Ser Trp Val Glu Pro Trp Phe Lys Pro Leu Ala Tyr 
            340                 345                 350         


Ala Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr Gly 
        355                 360                 365             


Asp Tyr Tyr Gly Ile Pro Lys Tyr Asn Ile Pro Gly Leu Lys Ser Lys 
    370                 375                 380                 


Ile Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr Gln 
385                 390                 395                 400 


Arg Asp Tyr Ile Asp His Gln Asp Ile Ile Gly Trp Thr Arg Glu Gly 
                405                 410                 415     


Ile Asp Ser Lys Pro Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly 
            420                 425                 430         


Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Lys His Ala Gly Lys 
        435                 440                 445             


Val Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile Asn 
    450                 455                 460                 


Ala Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser Ile 
465                 470                 475                 480 


Trp Val Ala Lys 
                


<210>  34
<211>  484
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  34

Asn Thr Ala Pro Val Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Asp 
1               5                   10                  15      


Leu Pro Asn Asp Gly Thr Leu Trp Thr Lys Val Lys Asn Glu Ala Ala 
            20                  25                  30          


Asn Leu Ser Ser Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Gln Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Asp Gln Tyr Ile Gln Ala Ile Gln Ala Ala Lys Ala Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Lys Ala Gly Ala Asp 
            100                 105                 110         


Gly Thr Glu Leu Val Asp Ala Val Glu Val Asn Pro Ser Asp Arg Asn 
        115                 120                 125             


Gln Glu Ile Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Glu Ser Arg Lys Leu Asn Arg Ile 
                165                 170                 175     


Tyr Lys Phe Arg Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Asp Thr 
            180                 185                 190         


Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Leu Asp Met Asp 
        195                 200                 205             


His Pro Glu Val Val Thr Glu Leu Lys Asn Trp Gly Lys Trp Tyr Val 
    210                 215                 220                 


Asn Thr Thr Asn Val Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile 
225                 230                 235                 240 


Lys Tyr Ser Phe Phe Pro Asp Trp Leu Ala Ser Val Arg Ser Gln Thr 
                245                 250                 255     


Gly Lys Asn Leu Phe Ala Val Gly Glu Phe Trp Ser Tyr Asp Val Asn 
            260                 265                 270         


Lys Leu His Asn Tyr Ile Thr Lys Thr Asn Gly Thr Met Ser Leu Phe 
        275                 280                 285             


Asp Ala Pro Leu His Asn Asn Phe Tyr Thr Ala Ser Lys Ser Ser Gly 
    290                 295                 300                 


Tyr Phe Asp Met Arg Tyr Leu Leu Asn Asn Thr Leu Met Lys Asp Gln 
305                 310                 315                 320 


Pro Val Leu Ala Val Thr Leu Val Asp Asn His Asp Thr Gln Pro Gly 
                325                 330                 335     


Gln Ser Leu Gln Ser Trp Val Glu Pro Trp Phe Lys Pro Leu Ala Tyr 
            340                 345                 350         


Ala Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr Gly 
        355                 360                 365             


Asp Tyr Tyr Gly Ile Pro Lys Tyr Asn Ile Pro Gly Leu Lys Ser Lys 
    370                 375                 380                 


Ile Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr Gln 
385                 390                 395                 400 


Arg Asp Tyr Ile Asp His Gln Asp Ile Ile Gly Trp Thr Arg Glu Gly 
                405                 410                 415     


Ile Asp Ser Lys Pro Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly 
            420                 425                 430         


Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Lys His Ala Gly Lys 
        435                 440                 445             


Val Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile Asn 
    450                 455                 460                 


Ala Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser Ile 
465                 470                 475                 480 


Trp Val Ala Lys 
                


<210>  35
<211>  483
<212>  PRT
<213>  Artifical Sequence

<400>  35

Asn Thr Ala Pro Val Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Asp 
1               5                   10                  15      


Leu Pro Asn Asp Gly Thr Leu Trp Thr Lys Val Lys Asn Glu Ala Ala 
            20                  25                  30          


Asn Leu Ser Ser Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Gln Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Asp Gln Tyr Ile Gln Ala Ile Gln Ala Ala Lys Ala Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Lys Ala Gly Ala Asp 
            100                 105                 110         


Gly Thr Glu Phe Val Asp Ala Val Glu Val Asp Pro Ser Asn Arg Asn 
        115                 120                 125             


Gln Glu Thr Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Glu Ser Arg Lys Leu Asn Arg Ile 
                165                 170                 175     


Tyr Lys Phe Ser Thr Gly Lys Ala Trp Asp Trp Glu Val Asp Thr Glu 
            180                 185                 190         


Asn Gly Asn Tyr Asp Tyr Leu Met Phe Ala Asp Leu Asp Met Asp His 
        195                 200                 205             


Pro Glu Val Val Thr Glu Leu Lys Asn Trp Gly Lys Trp Tyr Val Asn 
    210                 215                 220                 


Thr Thr Asn Val Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile Lys 
225                 230                 235                 240 


Tyr Ser Phe Phe Pro Asp Trp Leu Ala Ser Val Arg Ser Gln Thr Gly 
                245                 250                 255     


Lys Asn Leu Phe Ala Val Gly Glu Phe Trp Ser Tyr Asp Val Asn Lys 
            260                 265                 270         


Leu His Asn Tyr Ile Thr Lys Thr Asn Gly Thr Met Ser Leu Phe Asp 
        275                 280                 285             


Ala Pro Leu His Asn Asn Phe Tyr Thr Ala Ser Lys Ser Ser Gly Tyr 
    290                 295                 300                 


Phe Asp Met Arg Tyr Leu Leu Asn Asn Thr Leu Met Lys Asp Gln Pro 
305                 310                 315                 320 


Val Leu Ala Val Thr Leu Val Asp Asn His Asp Thr Gln Pro Gly Gln 
                325                 330                 335     


Ser Leu Gln Ser Trp Val Glu Pro Trp Phe Lys Pro Leu Ala Tyr Ala 
            340                 345                 350         


Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr Gly Asp 
        355                 360                 365             


Tyr Tyr Gly Ile Pro Lys Tyr Asn Ile Pro Gly Leu Lys Ser Lys Ile 
    370                 375                 380                 


Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr Gln Arg 
385                 390                 395                 400 


Asp Tyr Ile Asp His Gln Asp Ile Ile Gly Trp Thr Arg Glu Gly Ile 
                405                 410                 415     


Asp Ser Lys Pro Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly Pro 
            420                 425                 430         


Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Lys His Ala Gly Lys Val 
        435                 440                 445             


Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile Asn Ala 
    450                 455                 460                 


Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser Ile Trp 
465                 470                 475                 480 


Val Ala Lys 
            


<210>  36
<211>  484
<212>  PRT
<213>  Artifical Sequence

<400>  36

Asn Thr Ala Pro Val Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Asp 
1               5                   10                  15      


Leu Pro Asn Asp Gly Thr Leu Trp Thr Lys Val Lys Asn Glu Ala Ala 
            20                  25                  30          


Asn Leu Ser Ser Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Gln Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Asp Gln Tyr Ile Gln Ala Ile Gln Ala Ala Lys Ala Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Lys Ala Gly Ala Asp 
            100                 105                 110         


Gly Thr Glu Phe Val Asp Ala Val Glu Val Asn Pro Ser Asn Arg Asn 
        115                 120                 125             


Gln Glu Thr Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Glu Ser Arg Lys Leu Asn Arg Ile 
                165                 170                 175     


Tyr Lys Phe Arg Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Asp Thr 
            180                 185                 190         


Glu Asn Gly Asn Tyr Asp Tyr Leu Met Phe Ala Asp Leu Asp Met Asp 
        195                 200                 205             


His Pro Glu Val Val Thr Glu Leu Lys Asn Trp Gly Lys Trp Tyr Val 
    210                 215                 220                 


Asn Thr Thr Asn Val Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile 
225                 230                 235                 240 


Lys Tyr Ser Phe Phe Pro Asp Trp Leu Ala Ser Val Arg Ser Gln Thr 
                245                 250                 255     


Gly Lys Asn Leu Phe Ala Val Gly Glu Phe Trp Ser Tyr Asp Val Asn 
            260                 265                 270         


Lys Leu His Asn Tyr Ile Thr Lys Thr Asn Gly Thr Met Ser Leu Phe 
        275                 280                 285             


Asp Ala Pro Leu His Asn Asn Phe Tyr Thr Ala Ser Lys Ser Ser Gly 
    290                 295                 300                 


Tyr Phe Asp Met Arg Tyr Leu Leu Asn Asn Thr Leu Met Lys Asp Gln 
305                 310                 315                 320 


Pro Val Leu Ala Val Thr Leu Val Asp Asn His Asp Thr Gln Pro Gly 
                325                 330                 335     


Gln Ser Leu Gln Ser Trp Val Glu Pro Trp Phe Lys Pro Leu Ala Tyr 
            340                 345                 350         


Ala Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr Gly 
        355                 360                 365             


Asp Tyr Tyr Gly Ile Pro Lys Tyr Asn Ile Pro Gly Leu Lys Ser Lys 
    370                 375                 380                 


Ile Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr Gln 
385                 390                 395                 400 


Arg Asp Tyr Ile Asp His Gln Asp Ile Ile Gly Trp Thr Arg Glu Gly 
                405                 410                 415     


Ile Asp Ser Lys Pro Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly 
            420                 425                 430         


Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Lys His Ala Gly Lys 
        435                 440                 445             


Val Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile Asn 
    450                 455                 460                 


Ala Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser Ile 
465                 470                 475                 480 


Trp Val Ala Lys 
                


<210>  37
<211>  484
<212>  PRT
<213>  Artifiical Sequence

<400>  37

Asn Thr Ala Pro Val Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Asp 
1               5                   10                  15      


Leu Pro Asn Asp Gly Thr Leu Trp Thr Lys Val Lys Asn Glu Ala Ala 
            20                  25                  30          


Asn Leu Ser Ser Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Gln Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Asp Gln Tyr Ile Gln Ala Ile Gln Ala Ala Lys Ala Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Lys Ala Gly Ala Asp 
            100                 105                 110         


Ala Thr Glu Trp Val Asp Ala Val Glu Val Asn Pro Ser Asn Arg Asn 
        115                 120                 125             


Gln Glu Val Ser Gly Thr Tyr Lys Ile Gln Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Gln Ser Arg Gln Leu Asn Arg Ile 
                165                 170                 175     


Tyr Lys Phe Arg Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Asp Thr 
            180                 185                 190         


Glu Asn Gly Asn Tyr Asp Tyr Leu Met Phe Ala Asp Leu Asp Met Asp 
        195                 200                 205             


His Pro Glu Val Val Thr Glu Leu Lys Asn Trp Gly Lys Trp Tyr Val 
    210                 215                 220                 


Asn Thr Thr Asn Val Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile 
225                 230                 235                 240 


Lys Tyr Ser Phe Phe Pro Asp Trp Leu Ala Ser Val Arg Ser Gln Thr 
                245                 250                 255     


Gly Lys Asn Leu Phe Ala Val Gly Glu Phe Trp Ser Tyr Asp Val Asn 
            260                 265                 270         


Lys Leu His Asn Tyr Ile Thr Lys Thr Asn Gly Thr Met Ser Leu Phe 
        275                 280                 285             


Asp Ala Pro Leu His Asn Asn Phe Tyr Thr Ala Ser Lys Ser Ser Gly 
    290                 295                 300                 


Tyr Phe Asp Met Arg Tyr Leu Leu Asn Asn Thr Leu Met Lys Asp Gln 
305                 310                 315                 320 


Pro Val Leu Ala Val Thr Leu Val Asp Asn His Asp Thr Gln Pro Gly 
                325                 330                 335     


Gln Ser Leu Gln Ser Trp Val Glu Pro Trp Phe Lys Pro Leu Ala Tyr 
            340                 345                 350         


Ala Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr Gly 
        355                 360                 365             


Asp Tyr Tyr Gly Ile Pro Lys Tyr Asn Ile Pro Gly Leu Lys Ser Lys 
    370                 375                 380                 


Ile Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr Gln 
385                 390                 395                 400 


Arg Asp Tyr Ile Asp His Gln Asp Ile Ile Gly Trp Thr Arg Glu Gly 
                405                 410                 415     


Ile Asp Ser Lys Pro Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly 
            420                 425                 430         


Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Lys His Ala Gly Lys 
        435                 440                 445             


Val Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile Asn 
    450                 455                 460                 


Ala Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser Ile 
465                 470                 475                 480 


Trp Val Ala Lys 
                


<210>  38
<211>  484
<212>  PRT
<213>  Artifical Sequence

<400>  38

Asn Thr Ala Pro Val Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Asp 
1               5                   10                  15      


Leu Pro Asn Asp Gly Thr Leu Trp Thr Lys Val Lys Asn Glu Ala Ala 
            20                  25                  30          


Asn Leu Ser Ser Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Gln Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Asp Gln Tyr Ile Gln Ala Ile Gln Ala Ala Lys Ala Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Lys Ala Gly Ala Asp 
            100                 105                 110         


Ser Thr Glu Trp Val Asp Ala Val Glu Val Asn Pro Ser Asn Arg Asn 
        115                 120                 125             


Gln Glu Thr Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Glu Ser Arg Lys Leu Asn Arg Ile 
                165                 170                 175     


Tyr Lys Phe Arg Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Asp Thr 
            180                 185                 190         


Glu Asn Gly Asn Tyr Asp Tyr Leu Met Phe Ala Asp Leu Asp Met Asp 
        195                 200                 205             


His Pro Glu Val Val Thr Glu Leu Lys Asn Trp Gly Lys Trp Tyr Val 
    210                 215                 220                 


Asn Thr Thr Asn Val Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile 
225                 230                 235                 240 


Lys Tyr Ser Phe Phe Pro Asp Trp Leu Ala Ser Val Arg Ser Gln Thr 
                245                 250                 255     


Gly Lys Asn Leu Phe Ala Val Gly Glu Phe Trp Ser Tyr Asp Val Asn 
            260                 265                 270         


Lys Leu His Asn Tyr Ile Thr Lys Thr Asn Gly Thr Met Ser Leu Phe 
        275                 280                 285             


Asp Ala Pro Leu His Asn Asn Phe Tyr Thr Ala Ser Lys Ser Ser Gly 
    290                 295                 300                 


Tyr Phe Asp Met Arg Tyr Leu Leu Asn Asn Thr Leu Met Lys Asp Gln 
305                 310                 315                 320 


Pro Val Leu Ala Val Thr Leu Val Asp Asn His Asp Thr Gln Pro Gly 
                325                 330                 335     


Gln Ser Leu Gln Ser Trp Val Glu Pro Trp Phe Lys Pro Leu Ala Tyr 
            340                 345                 350         


Ala Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr Gly 
        355                 360                 365             


Asp Tyr Tyr Gly Ile Pro Lys Tyr Asn Ile Pro Gly Leu Lys Ser Lys 
    370                 375                 380                 


Ile Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr Gln 
385                 390                 395                 400 


Arg Asp Tyr Ile Asp His Gln Asp Ile Ile Gly Trp Thr Arg Glu Gly 
                405                 410                 415     


Ile Asp Ser Lys Pro Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly 
            420                 425                 430         


Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Lys His Ala Gly Lys 
        435                 440                 445             


Val Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile Asn 
    450                 455                 460                 


Ala Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser Ile 
465                 470                 475                 480 


Trp Val Ala Lys 
                


<210>  39
<211>  485
<212>  PRT
<213>  Artifical Sequence

<400>  39

Asn Thr Ala Pro Val Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Asp 
1               5                   10                  15      


Leu Pro Asn Asp Gly Thr Leu Trp Thr Lys Val Lys Asn Glu Ala Ala 
            20                  25                  30          


Asn Leu Ser Ser Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Gln Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Asp Gln Tyr Ile Gln Ala Ile Gln Ala Ala Lys Ala Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Lys Gly Gly Ala Asp 
            100                 105                 110         


Phe Thr Glu Arg Val Gln Ala Val Glu Val Asn Pro Gln Asn Arg Asn 
        115                 120                 125             


Gln Glu Val Ser Gly Thr Tyr Gln Ile Glu Ala Trp Thr Gly Phe Asn 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Gln His Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Gln Ser Arg Gln Leu Ala Asn Arg 
                165                 170                 175     


Ile Tyr Lys Phe Arg Gly Asp Gly Lys Ala Trp Asp Trp Glu Val Asp 
            180                 185                 190         


Thr Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Val Asp Met 
        195                 200                 205             


Asp His Pro Glu Val Val Thr Glu Leu Lys Asn Trp Gly Lys Trp Tyr 
    210                 215                 220                 


Val Asn Thr Thr Asn Val Asp Gly Phe Arg Leu Asp Ala Val Lys His 
225                 230                 235                 240 


Ile Lys Tyr Ser Phe Phe Pro Asp Trp Leu Ala Ser Val Arg Ser Gln 
                245                 250                 255     


Thr Gly Lys Asn Leu Phe Ala Val Gly Glu Phe Trp Ser Tyr Asp Val 
            260                 265                 270         


Asn Lys Leu His Asn Tyr Ile Thr Lys Thr Asn Gly Thr Met Ser Leu 
        275                 280                 285             


Phe Asp Ala Pro Leu His Asn Asn Phe Tyr Thr Ala Ser Lys Ser Ser 
    290                 295                 300                 


Gly Tyr Phe Asp Met Arg Tyr Leu Leu Asn Asn Thr Leu Met Lys Asp 
305                 310                 315                 320 


Gln Pro Val Leu Ala Val Thr Leu Val Asp Asn His Asp Thr Gln Pro 
                325                 330                 335     


Gly Gln Ser Leu Gln Ser Trp Val Glu Pro Trp Phe Lys Pro Leu Ala 
            340                 345                 350         


Tyr Ala Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr 
        355                 360                 365             


Gly Asp Tyr Tyr Gly Ile Pro Lys Tyr Asn Ile Pro Gly Leu Lys Ser 
    370                 375                 380                 


Lys Ile Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr 
385                 390                 395                 400 


Gln Arg Asp Tyr Ile Asp His Gln Asp Ile Ile Gly Trp Thr Arg Glu 
                405                 410                 415     


Gly Ile Asp Ser Lys Pro Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp 
            420                 425                 430         


Gly Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Lys His Ala Gly 
        435                 440                 445             


Lys Val Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile 
    450                 455                 460                 


Asn Ala Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser 
465                 470                 475                 480 


Ile Trp Val Ala Lys 
                485 


<210>  40
<211>  485
<212>  PRT
<213>  Artifiical Sequence

<400>  40

Asn Thr Ala Pro Val Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Asp 
1               5                   10                  15      


Leu Pro Asn Asp Gly Thr Leu Trp Thr Lys Val Lys Asn Glu Ala Ala 
            20                  25                  30          


Asn Leu Ser Ser Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Gln Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Asp Gln Tyr Ile Gln Ala Ile Gln Ala Ala Lys Ala Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Lys Gly Gly Ala Asp 
            100                 105                 110         


Ala Thr Glu Asn Val Leu Ala Val Glu Val Asn Pro Asn Asn Arg Asn 
        115                 120                 125             


Gln Glu Ile Ser Gly Asp Tyr Thr Ile Glu Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Asp Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Val Asp Trp Asp Gln Ser Arg Gln Phe Gln Asn Arg 
                165                 170                 175     


Ile Tyr Lys Phe Arg Gly Asp Gly Lys Ala Trp Asp Trp Glu Val Asp 
            180                 185                 190         


Ser Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Val Asp Met 
        195                 200                 205             


Asp His Pro Glu Val Val Thr Glu Leu Lys Asn Trp Gly Lys Trp Tyr 
    210                 215                 220                 


Val Asn Thr Thr Asn Val Asp Gly Phe Arg Leu Asp Ala Val Lys His 
225                 230                 235                 240 


Ile Lys Tyr Ser Phe Phe Pro Asp Trp Leu Ala Ser Val Arg Ser Gln 
                245                 250                 255     


Thr Gly Lys Asn Leu Phe Ala Val Gly Glu Phe Trp Ser Tyr Asp Val 
            260                 265                 270         


Asn Lys Leu His Asn Tyr Ile Thr Lys Thr Asn Gly Thr Met Ser Leu 
        275                 280                 285             


Phe Asp Ala Pro Leu His Asn Asn Phe Tyr Thr Ala Ser Lys Ser Ser 
    290                 295                 300                 


Gly Tyr Phe Asp Met Arg Tyr Leu Leu Asn Asn Thr Leu Met Lys Asp 
305                 310                 315                 320 


Gln Pro Val Leu Ala Val Thr Leu Val Asp Asn His Asp Thr Gln Pro 
                325                 330                 335     


Gly Gln Ser Leu Gln Ser Trp Val Glu Pro Trp Phe Lys Pro Leu Ala 
            340                 345                 350         


Tyr Ala Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr 
        355                 360                 365             


Gly Asp Tyr Tyr Gly Ile Pro Lys Tyr Asn Ile Pro Gly Leu Lys Ser 
    370                 375                 380                 


Lys Ile Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr 
385                 390                 395                 400 


Gln Arg Asp Tyr Ile Asp His Gln Asp Ile Ile Gly Trp Thr Arg Glu 
                405                 410                 415     


Gly Ile Asp Ser Lys Pro Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp 
            420                 425                 430         


Gly Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Lys His Ala Gly 
        435                 440                 445             


Lys Val Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile 
    450                 455                 460                 


Asn Ala Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser 
465                 470                 475                 480 


Ile Trp Val Ala Lys 
                485 


<210>  41
<211>  485
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  41

Asn Thr Ala Pro Val Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Asp 
1               5                   10                  15      


Leu Pro Asn Asp Gly Thr Leu Trp Thr Lys Val Lys Asn Glu Ala Ala 
            20                  25                  30          


Asn Leu Ser Ser Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Gln Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Asp Gln Tyr Ile Gln Ala Ile Gln Ala Ala Lys Ala Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Lys Gly Gly Ala Asp 
            100                 105                 110         


Ala Thr Glu Met Val Arg Ala Val Glu Val Asn Pro Asn Asn Arg Asn 
        115                 120                 125             


Gln Glu Val Ser Gly Glu Tyr Thr Ile Glu Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr His Ser Asn Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Val Asp Trp Asp Gln Ser Arg Lys Leu Asn Asn Arg 
                165                 170                 175     


Ile Tyr Lys Phe Arg Gly Asp Gly Lys Gly Trp Asp Trp Glu Val Asp 
            180                 185                 190         


Thr Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Ile Asp Met 
        195                 200                 205             


Asp His Pro Glu Val Val Thr Glu Leu Lys Asn Trp Gly Lys Trp Tyr 
    210                 215                 220                 


Val Asn Thr Thr Asn Val Asp Gly Phe Arg Leu Asp Ala Val Lys His 
225                 230                 235                 240 


Ile Lys Tyr Ser Phe Phe Pro Asp Trp Leu Ala Ser Val Arg Ser Gln 
                245                 250                 255     


Thr Gly Lys Asn Leu Phe Ala Val Gly Glu Phe Trp Ser Tyr Asp Val 
            260                 265                 270         


Asn Lys Leu His Asn Tyr Ile Thr Lys Thr Asn Gly Thr Met Ser Leu 
        275                 280                 285             


Phe Asp Ala Pro Leu His Asn Asn Phe Tyr Thr Ala Ser Lys Ser Ser 
    290                 295                 300                 


Gly Tyr Phe Asp Met Arg Tyr Leu Leu Asn Asn Thr Leu Met Lys Asp 
305                 310                 315                 320 


Gln Pro Val Leu Ala Val Thr Leu Val Asp Asn His Asp Thr Gln Pro 
                325                 330                 335     


Gly Gln Ser Leu Gln Ser Trp Val Glu Pro Trp Phe Lys Pro Leu Ala 
            340                 345                 350         


Tyr Ala Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr 
        355                 360                 365             


Gly Asp Tyr Tyr Gly Ile Pro Lys Tyr Asn Ile Pro Gly Leu Lys Ser 
    370                 375                 380                 


Lys Ile Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr 
385                 390                 395                 400 


Gln Arg Asp Tyr Ile Asp His Gln Asp Ile Ile Gly Trp Thr Arg Glu 
                405                 410                 415     


Gly Ile Asp Ser Lys Pro Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp 
            420                 425                 430         


Gly Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Lys His Ala Gly 
        435                 440                 445             


Lys Val Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile 
    450                 455                 460                 


Asn Ala Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser 
465                 470                 475                 480 


Ile Trp Val Ala Lys 
                485 


<210>  42
<211>  485
<212>  PRT
<213>  Artifical Sequence

<400>  42

Asn Thr Ala Pro Val Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Asp 
1               5                   10                  15      


Leu Pro Asn Asp Gly Thr Leu Trp Thr Lys Val Lys Asn Glu Ala Ala 
            20                  25                  30          


Asn Leu Ser Ser Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Gln Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Asp Gln Tyr Ile Gln Ala Ile Gln Ala Ala Lys Ala Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Lys Gly Gly Ala Asp 
            100                 105                 110         


Ala Thr Glu Met Val Arg Ala Val Glu Val Asn Pro Asn Asn Arg Asn 
        115                 120                 125             


Gln Glu Val Thr Gly Glu Tyr Thr Ile Glu Ala Trp Thr Arg Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr His Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Val Asp Trp Asp Gln Ser Arg Arg Leu Asn Asn Arg 
                165                 170                 175     


Ile Tyr Lys Phe Arg Gly His Gly Lys Ala Trp Asp Trp Glu Val Asp 
            180                 185                 190         


Thr Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Ile Asp Met 
        195                 200                 205             


Asp His Pro Glu Val Val Thr Glu Leu Lys Asn Trp Gly Lys Trp Tyr 
    210                 215                 220                 


Val Asn Thr Thr Asn Val Asp Gly Phe Arg Leu Asp Ala Val Lys His 
225                 230                 235                 240 


Ile Lys Tyr Ser Phe Phe Pro Asp Trp Leu Ala Ser Val Arg Ser Gln 
                245                 250                 255     


Thr Gly Lys Asn Leu Phe Ala Val Gly Glu Phe Trp Ser Tyr Asp Val 
            260                 265                 270         


Asn Lys Leu His Asn Tyr Ile Thr Lys Thr Asn Gly Thr Met Ser Leu 
        275                 280                 285             


Phe Asp Ala Pro Leu His Asn Asn Phe Tyr Thr Ala Ser Lys Ser Ser 
    290                 295                 300                 


Gly Tyr Phe Asp Met Arg Tyr Leu Leu Asn Asn Thr Leu Met Lys Asp 
305                 310                 315                 320 


Gln Pro Val Leu Ala Val Thr Leu Val Asp Asn His Asp Thr Gln Pro 
                325                 330                 335     


Gly Gln Ser Leu Gln Ser Trp Val Glu Pro Trp Phe Lys Pro Leu Ala 
            340                 345                 350         


Tyr Ala Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr 
        355                 360                 365             


Gly Asp Tyr Tyr Gly Ile Pro Lys Tyr Asn Ile Pro Gly Leu Lys Ser 
    370                 375                 380                 


Lys Ile Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr 
385                 390                 395                 400 


Gln Arg Asp Tyr Ile Asp His Gln Asp Ile Ile Gly Trp Thr Arg Glu 
                405                 410                 415     


Gly Ile Asp Ser Lys Pro Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp 
            420                 425                 430         


Gly Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Lys His Ala Gly 
        435                 440                 445             


Lys Val Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile 
    450                 455                 460                 


Asn Ala Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser 
465                 470                 475                 480 


Ile Trp Val Ala Lys 
                485 


<210>  43
<211>  485
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  43

Asn Thr Ala Pro Ile Asn Glu Thr Met Met Gln Tyr Phe Glu Trp Asp 
1               5                   10                  15      


Leu Pro Asn Asp Gly Thr Leu Trp Thr Lys Val Lys Asn Glu Ala Ala 
            20                  25                  30          


Asn Leu Ser Ser Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Gln Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Ile Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Thr Gln Tyr Ile Gln Ala Ile Gln Ala Ala Lys Ala Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Arg Met Gly Ala Asp 
            100                 105                 110         


Ala Thr Glu Thr Ile Ser Ala Val Glu Val Asn Pro Ser Asn Arg Asn 
        115                 120                 125             


Gln Val Thr Ser Gly Ala Tyr Asn Ile Ser Ala Trp Thr Asp Phe Glu 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp His Ser Tyr 
145                 150                 155                 160 


Tyr Phe Asp Gly Val Asp Trp Asp Gln Ser Arg Gln Leu Ser Gly Lys 
                165                 170                 175     


Ile Tyr Gln Ile Gln Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Asp 
            180                 185                 190         


Ser Glu Asn Gly Asn Tyr Asp Tyr Leu Met Gly Ala Asp Ile Asp Met 
        195                 200                 205             


Asp His Pro Glu Val Val Thr Glu Leu Lys Asn Trp Gly Thr Trp Tyr 
    210                 215                 220                 


Val Asn Thr Thr Asn Ile Asp Gly Phe Arg Leu Asp Ala Val Lys His 
225                 230                 235                 240 


Ile Lys Tyr Ser Phe Phe Pro Asp Trp Leu Thr Tyr Val Arg Asn Gln 
                245                 250                 255     


Thr Gly Lys Asn Leu Phe Ala Val Gly Glu Phe Trp Ser Tyr Asp Val 
            260                 265                 270         


Asn Lys Leu His Asn Tyr Ile Thr Lys Thr Asn Gly Ser Met Ser Leu 
        275                 280                 285             


Phe Asp Ala Pro Leu His Asn Asn Phe Tyr Thr Ala Ser Lys Ser Ser 
    290                 295                 300                 


Gly Tyr Phe Asp Met Arg Tyr Leu Leu Asn Asn Thr Leu Met Lys Asp 
305                 310                 315                 320 


Gln Pro Ser Leu Ala Val Thr Leu Val Asp Asn His Asp Thr Gln Pro 
                325                 330                 335     


Gly Gln Ser Leu Gln Ser Trp Val Glu Pro Trp Phe Lys Pro Leu Ala 
            340                 345                 350         


Tyr Ala Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr 
        355                 360                 365             


Gly Asp Tyr Tyr Gly Ile Pro Lys Tyr Asn Ile Pro Gly Leu Lys Ser 
    370                 375                 380                 


Lys Ile Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr 
385                 390                 395                 400 


Gln Arg Asp Tyr Ile Asp His Gln Asp Ile Ile Gly Trp Thr Arg Glu 
                405                 410                 415     


Gly Ile Asp Thr Lys Pro Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp 
            420                 425                 430         


Gly Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Lys His Ala Gly 
        435                 440                 445             


Lys Val Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile 
    450                 455                 460                 


Asn Ala Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser 
465                 470                 475                 480 


Ile Trp Val Ala Lys 
                485 


<210>  44
<211>  484
<212>  PRT
<213>  Artifical Sequence

<400>  44

Asn Thr Ala Pro Ile Asn Glu Thr Met Met Gln Tyr Phe Glu Trp Asp 
1               5                   10                  15      


Leu Pro Asn Asp Gly Thr Leu Trp Thr Lys Val Lys Asn Glu Ala Ala 
            20                  25                  30          


Asn Leu Ser Ser Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Gln Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Ile Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Thr Gln Tyr Ile Gln Ala Ile Gln Ala Ala Lys Ala Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Lys Ala Gly Ala Asp 
            100                 105                 110         


Ala Thr Glu Asp Val Thr Ala Val Glu Val Asn Pro Ala Asn Arg Asn 
        115                 120                 125             


Gln Glu Thr Ser Glu Glu Tyr Gln Ile Lys Ala Trp Thr Asp Phe Arg 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Asp Phe Lys Trp His Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Ala Asp Trp Asp Glu Ser Arg Lys Ile Ser Arg Ile 
                165                 170                 175     


Phe Lys Phe Arg Gly Glu Gly Lys Ala Trp Asp Trp Glu Val Ser Ser 
            180                 185                 190         


Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Val Asp Met Asp 
        195                 200                 205             


His Pro Glu Val Val Thr Glu Leu Lys Asn Trp Gly Thr Trp Tyr Val 
    210                 215                 220                 


Asn Thr Thr Asn Ile Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile 
225                 230                 235                 240 


Lys Tyr Ser Phe Phe Pro Asp Trp Leu Thr Tyr Val Arg Asn Gln Thr 
                245                 250                 255     


Gly Lys Asn Leu Phe Ala Val Gly Glu Phe Trp Ser Tyr Asp Val Asn 
            260                 265                 270         


Lys Leu His Asn Tyr Ile Thr Lys Thr Asn Gly Ser Met Ser Leu Phe 
        275                 280                 285             


Asp Ala Pro Leu His Asn Asn Phe Tyr Thr Ala Ser Lys Ser Ser Gly 
    290                 295                 300                 


Tyr Phe Asp Met Arg Tyr Leu Leu Asn Asn Thr Leu Met Lys Asp Gln 
305                 310                 315                 320 


Pro Ser Leu Ala Val Thr Leu Val Asp Asn His Asp Thr Gln Pro Gly 
                325                 330                 335     


Gln Ser Leu Gln Ser Trp Val Glu Pro Trp Phe Lys Pro Leu Ala Tyr 
            340                 345                 350         


Ala Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr Gly 
        355                 360                 365             


Asp Tyr Tyr Gly Ile Pro Lys Tyr Asn Ile Pro Gly Leu Lys Ser Lys 
    370                 375                 380                 


Ile Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr Gln 
385                 390                 395                 400 


Arg Asp Tyr Ile Asp His Gln Asp Ile Ile Gly Trp Thr Arg Glu Gly 
                405                 410                 415     


Ile Asp Thr Lys Pro Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly 
            420                 425                 430         


Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Lys His Ala Gly Lys 
        435                 440                 445             


Val Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile Asn 
    450                 455                 460                 


Ala Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser Ile 
465                 470                 475                 480 


Trp Val Ala Lys 
                


<210>  45
<211>  482
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sythentic Construct

<400>  45

Asn Thr Ala Pro Ile Asn Glu Thr Met Met Gln Tyr Phe Glu Trp Asp 
1               5                   10                  15      


Leu Pro Asn Asp Gly Thr Leu Trp Thr Lys Val Lys Asn Glu Ala Ala 
            20                  25                  30          


Asn Leu Ser Ser Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Gln Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Ile Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Thr Gln Tyr Ile Gln Ala Ile Gln Ala Ala Lys Ala Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Lys Gly Gly Ala Asp 
            100                 105                 110         


Ala Thr Glu Asp Val Thr Ala Val Glu Val Asp Pro Ala Asp Arg Asn 
        115                 120                 125             


Arg Val Ile Ser Gly Glu His Leu Ile Lys Ala Trp Thr His Phe His 
    130                 135                 140                 


Phe Pro Gly Arg Gly Ser Thr Tyr Ser Asp Phe Lys Trp His Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Glu Ser Arg Lys Leu Asn Arg Ile 
                165                 170                 175     


Tyr Lys Phe Gln Gly Lys Ala Trp Asp Trp Glu Val Ser Asn Glu Phe 
            180                 185                 190         


Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Ile Asp Met Asp His Pro 
        195                 200                 205             


Glu Val Val Thr Glu Leu Lys Asn Trp Gly Thr Trp Tyr Val Asn Thr 
    210                 215                 220                 


Thr Asn Ile Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile Lys Tyr 
225                 230                 235                 240 


Ser Phe Phe Pro Asp Trp Leu Thr Tyr Val Arg Asn Gln Thr Gly Lys 
                245                 250                 255     


Asn Leu Phe Ala Val Gly Glu Phe Trp Ser Tyr Asp Val Asn Lys Leu 
            260                 265                 270         


His Asn Tyr Ile Thr Lys Thr Asn Gly Ser Met Ser Leu Phe Asp Ala 
        275                 280                 285             


Pro Leu His Asn Asn Phe Tyr Thr Ala Ser Lys Ser Ser Gly Tyr Phe 
    290                 295                 300                 


Asp Met Arg Tyr Leu Leu Asn Asn Thr Leu Met Lys Asp Gln Pro Ser 
305                 310                 315                 320 


Leu Ala Val Thr Leu Val Asp Asn His Asp Thr Gln Pro Gly Gln Ser 
                325                 330                 335     


Leu Gln Ser Trp Val Glu Pro Trp Phe Lys Pro Leu Ala Tyr Ala Phe 
            340                 345                 350         


Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr Gly Asp Tyr 
        355                 360                 365             


Tyr Gly Ile Pro Lys Tyr Asn Ile Pro Gly Leu Lys Ser Lys Ile Asp 
    370                 375                 380                 


Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr Gln Arg Asp 
385                 390                 395                 400 


Tyr Ile Asp His Gln Asp Ile Ile Gly Trp Thr Arg Glu Gly Ile Asp 
                405                 410                 415     


Thr Lys Pro Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly Pro Gly 
            420                 425                 430         


Gly Ser Lys Trp Met Tyr Val Gly Lys Lys His Ala Gly Lys Val Phe 
        435                 440                 445             


Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile Asn Ala Asp 
    450                 455                 460                 


Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser Ile Trp Val 
465                 470                 475                 480 


Ala Lys 
        


<210>  46
<211>  484
<212>  PRT
<213>  Artifiical Sequence

<400>  46

Asn Thr Ala Pro Ile Asn Glu Thr Met Met Gln Tyr Phe Glu Trp Asp 
1               5                   10                  15      


Leu Pro Asn Asp Gly Thr Leu Trp Thr Lys Val Lys Asn Glu Ala Ala 
            20                  25                  30          


Asn Leu Ser Ser Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Gln Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Ile Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Thr Gln Tyr Ile Gln Ala Ile Gln Ala Ala Lys Ala Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Lys Ala Gly Ala Asp 
            100                 105                 110         


Tyr Thr Glu Asn Val Thr Ala Val Glu Val Asn Pro Ser Asn Arg Asn 
        115                 120                 125             


Gln Glu Thr Ser Gly Glu Tyr Asn Ile Gln Ala Trp Thr Gly Phe Asn 
    130                 135                 140                 


Phe Pro Gly Arg Gly Thr Thr Tyr Ser Asn Phe Lys Trp Gln Trp Phe 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Gln Ser Arg Ser Leu Ser Arg Ile 
                165                 170                 175     


Phe Lys Phe Arg Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Ser Ser 
            180                 185                 190         


Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Ile Asp Met Asp 
        195                 200                 205             


His Pro Glu Val Val Thr Glu Leu Lys Asn Trp Gly Thr Trp Tyr Val 
    210                 215                 220                 


Asn Thr Thr Asn Ile Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile 
225                 230                 235                 240 


Lys Tyr Ser Phe Phe Pro Asp Trp Leu Thr Tyr Val Arg Asn Gln Thr 
                245                 250                 255     


Gly Lys Asn Leu Phe Ala Val Gly Glu Phe Trp Ser Tyr Asp Val Asn 
            260                 265                 270         


Lys Leu His Asn Tyr Ile Thr Lys Thr Asn Gly Ser Met Ser Leu Phe 
        275                 280                 285             


Asp Ala Pro Leu His Asn Asn Phe Tyr Thr Ala Ser Lys Ser Ser Gly 
    290                 295                 300                 


Tyr Phe Asp Met Arg Tyr Leu Leu Asn Asn Thr Leu Met Lys Asp Gln 
305                 310                 315                 320 


Pro Ser Leu Ala Val Thr Leu Val Asp Asn His Asp Thr Gln Pro Gly 
                325                 330                 335     


Gln Ser Leu Gln Ser Trp Val Glu Pro Trp Phe Lys Pro Leu Ala Tyr 
            340                 345                 350         


Ala Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr Gly 
        355                 360                 365             


Asp Tyr Tyr Gly Ile Pro Lys Tyr Asn Ile Pro Gly Leu Lys Ser Lys 
    370                 375                 380                 


Ile Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr Gln 
385                 390                 395                 400 


Arg Asp Tyr Ile Asp His Gln Asp Ile Ile Gly Trp Thr Arg Glu Gly 
                405                 410                 415     


Ile Asp Thr Lys Pro Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly 
            420                 425                 430         


Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Lys His Ala Gly Lys 
        435                 440                 445             


Val Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile Asn 
    450                 455                 460                 


Ala Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser Ile 
465                 470                 475                 480 


Trp Val Ala Lys 
                


<210>  47
<211>  484
<212>  PRT
<213>  Artifiical Sequence

<400>  47

Asn Thr Ala Pro Ile Asn Glu Thr Met Met Gln Tyr Phe Glu Trp Asp 
1               5                   10                  15      


Leu Pro Asn Asp Gly Thr Leu Trp Thr Lys Val Lys Asn Glu Ala Ala 
            20                  25                  30          


Asn Leu Ser Ser Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Gln Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Ile Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Thr Gln Tyr Ile Gln Ala Ile Gln Ala Ala Lys Ala Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asp His Lys Gly Gly Ala Asp 
            100                 105                 110         


Gly Thr Glu Trp Val Asp Ala Val Glu Val Asn Pro Ser Asp Arg Asn 
        115                 120                 125             


Gln Glu Ile Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Val Asp Trp Asp Glu Ser Arg Lys Leu Ser Arg Ile 
                165                 170                 175     


Tyr Lys Phe Arg Gly Ile Gly Lys Ala Trp Asp Trp Glu Val Asp Thr 
            180                 185                 190         


Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Leu Asp Met Asp 
        195                 200                 205             


His Pro Glu Val Val Thr Glu Leu Lys Asn Trp Gly Thr Trp Tyr Val 
    210                 215                 220                 


Asn Thr Thr Asn Ile Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile 
225                 230                 235                 240 


Lys Tyr Ser Phe Phe Pro Asp Trp Leu Thr Tyr Val Arg Asn Gln Thr 
                245                 250                 255     


Gly Lys Asn Leu Phe Ala Val Gly Glu Phe Trp Ser Tyr Asp Val Asn 
            260                 265                 270         


Lys Leu His Asn Tyr Ile Thr Lys Thr Asn Gly Ser Met Ser Leu Phe 
        275                 280                 285             


Asp Ala Pro Leu His Asn Asn Phe Tyr Thr Ala Ser Lys Ser Ser Gly 
    290                 295                 300                 


Tyr Phe Asp Met Arg Tyr Leu Leu Asn Asn Thr Leu Met Lys Asp Gln 
305                 310                 315                 320 


Pro Ser Leu Ala Val Thr Leu Val Asp Asn His Asp Thr Gln Pro Gly 
                325                 330                 335     


Gln Ser Leu Gln Ser Trp Val Glu Pro Trp Phe Lys Pro Leu Ala Tyr 
            340                 345                 350         


Ala Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr Gly 
        355                 360                 365             


Asp Tyr Tyr Gly Ile Pro Lys Tyr Asn Ile Pro Gly Leu Lys Ser Lys 
    370                 375                 380                 


Ile Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr Gln 
385                 390                 395                 400 


Arg Asp Tyr Ile Asp His Gln Asp Ile Ile Gly Trp Thr Arg Glu Gly 
                405                 410                 415     


Ile Asp Thr Lys Pro Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly 
            420                 425                 430         


Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Lys His Ala Gly Lys 
        435                 440                 445             


Val Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile Asn 
    450                 455                 460                 


Ala Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser Ile 
465                 470                 475                 480 


Trp Val Ala Lys 
                


<210>  48
<211>  484
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  48

Asn Thr Ala Pro Ile Asn Glu Thr Met Met Gln Tyr Phe Glu Trp Asp 
1               5                   10                  15      


Leu Pro Asn Asp Gly Thr Leu Trp Thr Lys Val Lys Asn Glu Ala Ala 
            20                  25                  30          


Asn Leu Ser Ser Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Gln Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Ile Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Thr Gln Tyr Ile Gln Ala Ile Gln Ala Ala Lys Ala Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Lys Ala Gly Ala Asp 
            100                 105                 110         


Gly Thr Glu Leu Val Asp Ala Val Glu Val Asn Pro Ser Asp Arg Asn 
        115                 120                 125             


Gln Glu Ile Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Glu Ser Arg Lys Leu Asn Arg Ile 
                165                 170                 175     


Tyr Lys Phe Arg Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Asp Thr 
            180                 185                 190         


Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Leu Asp Met Asp 
        195                 200                 205             


His Pro Glu Val Val Thr Glu Leu Lys Asn Trp Gly Thr Trp Tyr Val 
    210                 215                 220                 


Asn Thr Thr Asn Ile Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile 
225                 230                 235                 240 


Lys Tyr Ser Phe Phe Pro Asp Trp Leu Thr Tyr Val Arg Asn Gln Thr 
                245                 250                 255     


Gly Lys Asn Leu Phe Ala Val Gly Glu Phe Trp Ser Tyr Asp Val Asn 
            260                 265                 270         


Lys Leu His Asn Tyr Ile Thr Lys Thr Asn Gly Ser Met Ser Leu Phe 
        275                 280                 285             


Asp Ala Pro Leu His Asn Asn Phe Tyr Thr Ala Ser Lys Ser Ser Gly 
    290                 295                 300                 


Tyr Phe Asp Met Arg Tyr Leu Leu Asn Asn Thr Leu Met Lys Asp Gln 
305                 310                 315                 320 


Pro Ser Leu Ala Val Thr Leu Val Asp Asn His Asp Thr Gln Pro Gly 
                325                 330                 335     


Gln Ser Leu Gln Ser Trp Val Glu Pro Trp Phe Lys Pro Leu Ala Tyr 
            340                 345                 350         


Ala Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr Gly 
        355                 360                 365             


Asp Tyr Tyr Gly Ile Pro Lys Tyr Asn Ile Pro Gly Leu Lys Ser Lys 
    370                 375                 380                 


Ile Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr Gln 
385                 390                 395                 400 


Arg Asp Tyr Ile Asp His Gln Asp Ile Ile Gly Trp Thr Arg Glu Gly 
                405                 410                 415     


Ile Asp Thr Lys Pro Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly 
            420                 425                 430         


Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Lys His Ala Gly Lys 
        435                 440                 445             


Val Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile Asn 
    450                 455                 460                 


Ala Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser Ile 
465                 470                 475                 480 


Trp Val Ala Lys 
                


<210>  49
<211>  484
<212>  PRT
<213>  Artifiical Sequence

<400>  49

Asn Thr Ala Pro Ile Asn Glu Thr Met Met Gln Tyr Phe Glu Trp Asp 
1               5                   10                  15      


Leu Pro Asn Asp Gly Thr Leu Trp Thr Lys Val Lys Asn Glu Ala Ala 
            20                  25                  30          


Asn Leu Ser Ser Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Gln Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Ile Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Thr Gln Tyr Ile Gln Ala Ile Gln Ala Ala Lys Ala Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Lys Ala Gly Ala Asp 
            100                 105                 110         


Gly Thr Glu Phe Val Asp Ala Val Glu Val Asn Pro Ser Asn Arg Asn 
        115                 120                 125             


Gln Glu Thr Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Glu Ser Arg Lys Leu Asn Arg Val 
                165                 170                 175     


Tyr Lys Phe Arg Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Asp Thr 
            180                 185                 190         


Glu Asn Gly Asn Tyr Asp Tyr Leu Met Phe Ala Asp Leu Asp Met Asp 
        195                 200                 205             


His Pro Glu Val Val Thr Glu Leu Lys Asn Trp Gly Thr Trp Tyr Val 
    210                 215                 220                 


Asn Thr Thr Asn Ile Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile 
225                 230                 235                 240 


Lys Tyr Ser Phe Phe Pro Asp Trp Leu Thr Tyr Val Arg Asn Gln Thr 
                245                 250                 255     


Gly Lys Asn Leu Phe Ala Val Gly Glu Phe Trp Ser Tyr Asp Val Asn 
            260                 265                 270         


Lys Leu His Asn Tyr Ile Thr Lys Thr Asn Gly Ser Met Ser Leu Phe 
        275                 280                 285             


Asp Ala Pro Leu His Asn Asn Phe Tyr Thr Ala Ser Lys Ser Ser Gly 
    290                 295                 300                 


Tyr Phe Asp Met Arg Tyr Leu Leu Asn Asn Thr Leu Met Lys Asp Gln 
305                 310                 315                 320 


Pro Ser Leu Ala Val Thr Leu Val Asp Asn His Asp Thr Gln Pro Gly 
                325                 330                 335     


Gln Ser Leu Gln Ser Trp Val Glu Pro Trp Phe Lys Pro Leu Ala Tyr 
            340                 345                 350         


Ala Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr Gly 
        355                 360                 365             


Asp Tyr Tyr Gly Ile Pro Lys Tyr Asn Ile Pro Gly Leu Lys Ser Lys 
    370                 375                 380                 


Ile Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr Gln 
385                 390                 395                 400 


Arg Asp Tyr Ile Asp His Gln Asp Ile Ile Gly Trp Thr Arg Glu Gly 
                405                 410                 415     


Ile Asp Thr Lys Pro Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly 
            420                 425                 430         


Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Lys His Ala Gly Lys 
        435                 440                 445             


Val Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile Asn 
    450                 455                 460                 


Ala Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser Ile 
465                 470                 475                 480 


Trp Val Ala Lys 
                


<210>  50
<211>  484
<212>  PRT
<213>  Artifiical Sequence

<400>  50

Asn Thr Ala Pro Ile Asn Glu Thr Met Met Gln Tyr Phe Glu Trp Asp 
1               5                   10                  15      


Leu Pro Asn Asp Gly Thr Leu Trp Thr Lys Val Lys Asn Glu Ala Ala 
            20                  25                  30          


Asn Leu Ser Ser Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Gln Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Ile Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Thr Gln Tyr Ile Gln Ala Ile Gln Ala Ala Lys Ala Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Lys Ala Gly Ala Asp 
            100                 105                 110         


Gly Thr Glu Phe Val Asp Ala Val Glu Val Asn Pro Ser Asn Arg Asn 
        115                 120                 125             


Gln Glu Thr Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Glu Ser Arg Lys Leu Asn Arg Ile 
                165                 170                 175     


Tyr Lys Phe Arg Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Asp Thr 
            180                 185                 190         


Glu Asn Gly Asn Tyr Asp Tyr Leu Met Phe Ala Asp Leu Asp Met Asp 
        195                 200                 205             


His Pro Glu Val Val Thr Glu Leu Lys Asn Trp Gly Thr Trp Tyr Val 
    210                 215                 220                 


Asn Thr Thr Asn Ile Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile 
225                 230                 235                 240 


Lys Tyr Ser Phe Phe Pro Asp Trp Leu Thr Tyr Val Arg Asn Gln Thr 
                245                 250                 255     


Gly Lys Asn Leu Phe Ala Val Gly Glu Phe Trp Ser Tyr Asp Val Asn 
            260                 265                 270         


Lys Leu His Asn Tyr Ile Thr Lys Thr Asn Gly Ser Met Ser Leu Phe 
        275                 280                 285             


Asp Ala Pro Leu His Asn Asn Phe Tyr Thr Ala Ser Lys Ser Ser Gly 
    290                 295                 300                 


Tyr Phe Asp Met Arg Tyr Leu Leu Asn Asn Thr Leu Met Lys Asp Gln 
305                 310                 315                 320 


Pro Ser Leu Ala Val Thr Leu Val Asp Asn His Asp Thr Gln Pro Gly 
                325                 330                 335     


Gln Ser Leu Gln Ser Trp Val Glu Pro Trp Phe Lys Pro Leu Ala Tyr 
            340                 345                 350         


Ala Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr Gly 
        355                 360                 365             


Asp Tyr Tyr Gly Ile Pro Lys Tyr Asn Ile Pro Gly Leu Lys Ser Lys 
    370                 375                 380                 


Ile Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr Gln 
385                 390                 395                 400 


Arg Asp Tyr Ile Asp His Gln Asp Ile Ile Gly Trp Thr Arg Glu Gly 
                405                 410                 415     


Ile Asp Thr Lys Pro Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly 
            420                 425                 430         


Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Lys His Ala Gly Lys 
        435                 440                 445             


Val Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile Asn 
    450                 455                 460                 


Ala Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser Ile 
465                 470                 475                 480 


Trp Val Ala Lys 
                


<210>  51
<211>  484
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  51

Asn Thr Ala Pro Ile Asn Glu Thr Met Met Gln Tyr Phe Glu Trp Asp 
1               5                   10                  15      


Leu Pro Asn Asp Gly Thr Leu Trp Thr Lys Val Lys Asn Glu Ala Ala 
            20                  25                  30          


Asn Leu Ser Ser Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Gln Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Ile Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Thr Gln Tyr Ile Gln Ala Ile Gln Ala Ala Lys Ala Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Lys Ala Gly Ala Asp 
            100                 105                 110         


Ala Thr Glu Trp Val Asp Ala Val Glu Val Asn Pro Ser Asn Arg Asn 
        115                 120                 125             


Gln Glu Val Ser Gly Thr Tyr Lys Ile Gln Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Gln Ser Arg Gln Leu Asn Arg Ile 
                165                 170                 175     


Tyr Lys Phe Arg Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Asp Thr 
            180                 185                 190         


Glu Asn Gly Asn Tyr Asp Tyr Leu Met Phe Ala Asp Leu Asp Met Asp 
        195                 200                 205             


His Pro Glu Val Val Thr Glu Leu Lys Asn Trp Gly Thr Trp Tyr Val 
    210                 215                 220                 


Asn Thr Thr Asn Ile Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile 
225                 230                 235                 240 


Lys Tyr Ser Phe Phe Pro Asp Trp Leu Thr Tyr Val Arg Asn Gln Thr 
                245                 250                 255     


Gly Lys Asn Leu Phe Ala Val Gly Glu Phe Trp Ser Tyr Asp Val Asn 
            260                 265                 270         


Lys Leu His Asn Tyr Ile Thr Lys Thr Asn Gly Ser Met Ser Leu Phe 
        275                 280                 285             


Asp Ala Pro Leu His Asn Asn Phe Tyr Thr Ala Ser Lys Ser Ser Gly 
    290                 295                 300                 


Tyr Phe Asp Met Arg Tyr Leu Leu Asn Asn Thr Leu Met Lys Asp Gln 
305                 310                 315                 320 


Pro Ser Leu Ala Val Thr Leu Val Asp Asn His Asp Thr Gln Pro Gly 
                325                 330                 335     


Gln Ser Leu Gln Ser Trp Val Glu Pro Trp Phe Lys Pro Leu Ala Tyr 
            340                 345                 350         


Ala Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr Gly 
        355                 360                 365             


Asp Tyr Tyr Gly Ile Pro Lys Tyr Asn Ile Pro Gly Leu Lys Ser Lys 
    370                 375                 380                 


Ile Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr Gln 
385                 390                 395                 400 


Arg Asp Tyr Ile Asp His Gln Asp Ile Ile Gly Trp Thr Arg Glu Gly 
                405                 410                 415     


Ile Asp Thr Lys Pro Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly 
            420                 425                 430         


Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Lys His Ala Gly Lys 
        435                 440                 445             


Val Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile Asn 
    450                 455                 460                 


Ala Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser Ile 
465                 470                 475                 480 


Trp Val Ala Lys 
                


<210>  52
<211>  484
<212>  PRT
<213>  Artifical Sequence

<400>  52

Asn Thr Ala Pro Ile Asn Glu Thr Met Met Gln Tyr Phe Glu Trp Asp 
1               5                   10                  15      


Leu Pro Asn Asp Gly Thr Leu Trp Thr Lys Val Lys Asn Glu Ala Ala 
            20                  25                  30          


Asn Leu Ser Ser Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Gln Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Ile Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Thr Gln Tyr Ile Gln Ala Ile Gln Ala Ala Lys Ala Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Lys Ala Gly Ala Asp 
            100                 105                 110         


Ser Thr Glu Trp Val Asp Ala Val Glu Val Asn Pro Ser Asn Arg Asn 
        115                 120                 125             


Gln Glu Thr Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Glu Ser Arg Lys Leu Asn Arg Ile 
                165                 170                 175     


Tyr Lys Phe Arg Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Asp Thr 
            180                 185                 190         


Glu Asn Gly Asn Tyr Asp Tyr Leu Met Phe Ala Asp Leu Asp Met Asp 
        195                 200                 205             


His Pro Glu Val Val Thr Glu Leu Lys Asn Trp Gly Thr Trp Tyr Val 
    210                 215                 220                 


Asn Thr Thr Asn Ile Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile 
225                 230                 235                 240 


Lys Tyr Ser Phe Phe Pro Asp Trp Leu Thr Tyr Val Arg Asn Gln Thr 
                245                 250                 255     


Gly Lys Asn Leu Phe Ala Val Gly Glu Phe Trp Ser Tyr Asp Val Asn 
            260                 265                 270         


Lys Leu His Asn Tyr Ile Thr Lys Thr Asn Gly Ser Met Ser Leu Phe 
        275                 280                 285             


Asp Ala Pro Leu His Asn Asn Phe Tyr Thr Ala Ser Lys Ser Ser Gly 
    290                 295                 300                 


Tyr Phe Asp Met Arg Tyr Leu Leu Asn Asn Thr Leu Met Lys Asp Gln 
305                 310                 315                 320 


Pro Ser Leu Ala Val Thr Leu Val Asp Asn His Asp Thr Gln Pro Gly 
                325                 330                 335     


Gln Ser Leu Gln Ser Trp Val Glu Pro Trp Phe Lys Pro Leu Ala Tyr 
            340                 345                 350         


Ala Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr Gly 
        355                 360                 365             


Asp Tyr Tyr Gly Ile Pro Lys Tyr Asn Ile Pro Gly Leu Lys Ser Lys 
    370                 375                 380                 


Ile Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr Gln 
385                 390                 395                 400 


Arg Asp Tyr Ile Asp His Gln Asp Ile Ile Gly Trp Thr Arg Glu Gly 
                405                 410                 415     


Ile Asp Thr Lys Pro Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly 
            420                 425                 430         


Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Lys His Ala Gly Lys 
        435                 440                 445             


Val Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile Asn 
    450                 455                 460                 


Ala Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser Ile 
465                 470                 475                 480 


Trp Val Ala Lys 
                


<210>  53
<211>  485
<212>  PRT
<213>  Artifical Sequence

<400>  53

Asn Thr Ala Pro Ile Asn Glu Thr Met Met Gln Tyr Phe Glu Trp Asp 
1               5                   10                  15      


Leu Pro Asn Asp Gly Thr Leu Trp Thr Lys Val Lys Asn Glu Ala Ala 
            20                  25                  30          


Asn Leu Ser Ser Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Gln Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Ile Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Thr Gln Tyr Ile Gln Ala Ile Gln Ala Ala Lys Ala Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Lys Gly Gly Ala Asp 
            100                 105                 110         


Phe Thr Glu Arg Val Gln Ala Val Glu Val Asn Pro Gln Asn Arg Asn 
        115                 120                 125             


Gln Glu Val Ser Gly Thr Tyr Gln Ile Glu Ala Trp Thr Gly Phe Asn 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Gln His Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Gln Ser Arg Gln Leu Ala Asn Arg 
                165                 170                 175     


Ile Tyr Lys Phe Arg Gly Asp Gly Lys Ala Trp Asp Trp Glu Val Asp 
            180                 185                 190         


Thr Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Val Asp Met 
        195                 200                 205             


Asp His Pro Glu Val Val Thr Glu Leu Lys Asn Trp Gly Thr Trp Tyr 
    210                 215                 220                 


Val Asn Thr Thr Asn Ile Asp Gly Phe Arg Leu Asp Ala Val Lys His 
225                 230                 235                 240 


Ile Lys Tyr Ser Phe Phe Pro Asp Trp Leu Thr Tyr Val Arg Asn Gln 
                245                 250                 255     


Thr Gly Lys Asn Leu Phe Ala Val Gly Glu Phe Trp Ser Tyr Asp Val 
            260                 265                 270         


Asn Lys Leu His Asn Tyr Ile Thr Lys Thr Asn Gly Ser Met Ser Leu 
        275                 280                 285             


Phe Asp Ala Pro Leu His Asn Asn Phe Tyr Thr Ala Ser Lys Ser Ser 
    290                 295                 300                 


Gly Tyr Phe Asp Met Arg Tyr Leu Leu Asn Asn Thr Leu Met Lys Asp 
305                 310                 315                 320 


Gln Pro Ser Leu Ala Val Thr Leu Val Asp Asn His Asp Thr Gln Pro 
                325                 330                 335     


Gly Gln Ser Leu Gln Ser Trp Val Glu Pro Trp Phe Lys Pro Leu Ala 
            340                 345                 350         


Tyr Ala Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr 
        355                 360                 365             


Gly Asp Tyr Tyr Gly Ile Pro Lys Tyr Asn Ile Pro Gly Leu Lys Ser 
    370                 375                 380                 


Lys Ile Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr 
385                 390                 395                 400 


Gln Arg Asp Tyr Ile Asp His Gln Asp Ile Ile Gly Trp Thr Arg Glu 
                405                 410                 415     


Gly Ile Asp Thr Lys Pro Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp 
            420                 425                 430         


Gly Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Lys His Ala Gly 
        435                 440                 445             


Lys Val Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile 
    450                 455                 460                 


Asn Ala Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser 
465                 470                 475                 480 


Ile Trp Val Ala Lys 
                485 


<210>  54
<211>  485
<212>  PRT
<213>  Artifical Sequence

<400>  54

Asn Thr Ala Pro Ile Asn Glu Thr Met Met Gln Tyr Phe Glu Trp Asp 
1               5                   10                  15      


Leu Pro Asn Asp Gly Thr Leu Trp Thr Lys Val Lys Asn Glu Ala Ala 
            20                  25                  30          


Asn Leu Ser Ser Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Gln Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Ile Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Thr Gln Tyr Ile Gln Ala Ile Gln Ala Ala Lys Ala Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Lys Gly Gly Ala Asp 
            100                 105                 110         


Ala Thr Glu Asn Val Leu Ala Val Glu Val Asn Pro Asn Asn Arg Asn 
        115                 120                 125             


Gln Glu Ile Ser Gly Asp Tyr Thr Ile Glu Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Asp Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Val Asp Trp Asp Gln Ser Arg Gln Phe Gln Asn Arg 
                165                 170                 175     


Ile Tyr Lys Phe Arg Gly Asp Gly Lys Ala Trp Asp Trp Glu Val Asp 
            180                 185                 190         


Ser Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Val Asp Met 
        195                 200                 205             


Asp His Pro Glu Val Val Thr Glu Leu Lys Asn Trp Gly Thr Trp Tyr 
    210                 215                 220                 


Val Asn Thr Thr Asn Ile Asp Gly Phe Arg Leu Asp Ala Val Lys His 
225                 230                 235                 240 


Ile Lys Tyr Ser Phe Phe Pro Asp Trp Leu Thr Tyr Val Arg Asn Gln 
                245                 250                 255     


Thr Gly Lys Asn Leu Phe Ala Val Gly Glu Phe Trp Ser Tyr Asp Val 
            260                 265                 270         


Asn Lys Leu His Asn Tyr Ile Thr Lys Thr Asn Gly Ser Met Ser Leu 
        275                 280                 285             


Phe Asp Ala Pro Leu His Asn Asn Phe Tyr Thr Ala Ser Lys Ser Ser 
    290                 295                 300                 


Gly Tyr Phe Asp Met Arg Tyr Leu Leu Asn Asn Thr Leu Met Lys Asp 
305                 310                 315                 320 


Gln Pro Ser Leu Ala Val Thr Leu Val Asp Asn His Asp Thr Gln Pro 
                325                 330                 335     


Gly Gln Ser Leu Gln Ser Trp Val Glu Pro Trp Phe Lys Pro Leu Ala 
            340                 345                 350         


Tyr Ala Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr 
        355                 360                 365             


Gly Asp Tyr Tyr Gly Ile Pro Lys Tyr Asn Ile Pro Gly Leu Lys Ser 
    370                 375                 380                 


Lys Ile Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr 
385                 390                 395                 400 


Gln Arg Asp Tyr Ile Asp His Gln Asp Ile Ile Gly Trp Thr Arg Glu 
                405                 410                 415     


Gly Ile Asp Thr Lys Pro Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp 
            420                 425                 430         


Gly Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Lys His Ala Gly 
        435                 440                 445             


Lys Val Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile 
    450                 455                 460                 


Asn Ala Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser 
465                 470                 475                 480 


Ile Trp Val Ala Lys 
                485 


<210>  55
<211>  485
<212>  PRT
<213>  Artifical Sequence

<400>  55

Asn Thr Ala Pro Ile Asn Glu Thr Met Met Gln Tyr Phe Glu Trp Asp 
1               5                   10                  15      


Leu Pro Asn Asp Gly Thr Leu Trp Thr Lys Val Lys Asn Glu Ala Ala 
            20                  25                  30          


Asn Leu Ser Ser Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Gln Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Ile Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Thr Gln Tyr Ile Gln Ala Ile Gln Ala Ala Lys Ala Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Lys Gly Gly Ala Asp 
            100                 105                 110         


Ala Thr Glu Met Val Arg Ala Val Glu Val Asn Pro Asn Asn Arg Asn 
        115                 120                 125             


Gln Glu Val Ser Gly Glu Tyr Thr Ile Glu Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr His Ser Asn Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Val Asp Trp Asp Gln Ser Arg Lys Leu Asn Asn Arg 
                165                 170                 175     


Ile Tyr Lys Phe Arg Gly Asp Gly Lys Gly Trp Asp Trp Glu Val Asp 
            180                 185                 190         


Thr Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Ile Asp Met 
        195                 200                 205             


Asp His Pro Glu Val Val Thr Glu Leu Lys Asn Trp Gly Thr Trp Tyr 
    210                 215                 220                 


Val Asn Thr Thr Asn Ile Asp Gly Phe Arg Leu Asp Ala Val Lys His 
225                 230                 235                 240 


Ile Lys Tyr Ser Phe Phe Pro Asp Trp Leu Thr Tyr Val Arg Asn Gln 
                245                 250                 255     


Thr Gly Lys Asn Leu Phe Ala Val Gly Glu Phe Trp Ser Tyr Asp Val 
            260                 265                 270         


Asn Lys Leu His Asn Tyr Ile Thr Lys Thr Asn Gly Ser Met Ser Leu 
        275                 280                 285             


Phe Asp Ala Pro Leu His Asn Asn Phe Tyr Thr Ala Ser Lys Ser Ser 
    290                 295                 300                 


Gly Tyr Phe Asp Met Arg Tyr Leu Leu Asn Asn Thr Leu Met Lys Asp 
305                 310                 315                 320 


Gln Pro Ser Leu Ala Val Thr Leu Val Asp Asn His Asp Thr Gln Pro 
                325                 330                 335     


Gly Gln Ser Leu Gln Ser Trp Val Glu Pro Trp Phe Lys Pro Leu Ala 
            340                 345                 350         


Tyr Ala Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr 
        355                 360                 365             


Gly Asp Tyr Tyr Gly Ile Pro Lys Tyr Asn Ile Pro Gly Leu Lys Ser 
    370                 375                 380                 


Lys Ile Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr 
385                 390                 395                 400 


Gln Arg Asp Tyr Ile Asp His Gln Asp Ile Ile Gly Trp Thr Arg Glu 
                405                 410                 415     


Gly Ile Asp Thr Lys Pro Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp 
            420                 425                 430         


Gly Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Lys His Ala Gly 
        435                 440                 445             


Lys Val Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile 
    450                 455                 460                 


Asn Ala Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser 
465                 470                 475                 480 


Ile Trp Val Ala Lys 
                485 


<210>  56
<211>  485
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  56

Asn Thr Ala Pro Ile Asn Glu Thr Met Met Gln Tyr Phe Glu Trp Asp 
1               5                   10                  15      


Leu Pro Asn Asp Gly Thr Leu Trp Thr Lys Val Lys Asn Glu Ala Ala 
            20                  25                  30          


Asn Leu Ser Ser Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Gln Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Ile Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Thr Gln Tyr Ile Gln Ala Ile Gln Ala Ala Lys Ala Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Lys Gly Gly Ala Asp 
            100                 105                 110         


Ala Thr Glu Met Val Arg Ala Val Glu Val Asn Pro Asn Asn Arg Asn 
        115                 120                 125             


Gln Glu Val Thr Gly Glu Tyr Thr Ile Glu Ala Trp Thr Arg Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr His Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Val Asp Trp Asp Gln Ser Arg Arg Leu Asn Asn Arg 
                165                 170                 175     


Ile Tyr Lys Phe Arg Gly His Gly Lys Ala Trp Asp Trp Glu Val Asp 
            180                 185                 190         


Thr Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Ile Asp Met 
        195                 200                 205             


Asp His Pro Glu Val Val Thr Glu Leu Lys Asn Trp Gly Thr Trp Tyr 
    210                 215                 220                 


Val Asn Thr Thr Asn Ile Asp Gly Phe Arg Leu Asp Ala Val Lys His 
225                 230                 235                 240 


Ile Lys Tyr Ser Phe Phe Pro Asp Trp Leu Thr Tyr Val Arg Asn Gln 
                245                 250                 255     


Thr Gly Lys Asn Leu Phe Ala Val Gly Glu Phe Trp Ser Tyr Asp Val 
            260                 265                 270         


Asn Lys Leu His Asn Tyr Ile Thr Lys Thr Asn Gly Ser Met Ser Leu 
        275                 280                 285             


Phe Asp Ala Pro Leu His Asn Asn Phe Tyr Thr Ala Ser Lys Ser Ser 
    290                 295                 300                 


Gly Tyr Phe Asp Met Arg Tyr Leu Leu Asn Asn Thr Leu Met Lys Asp 
305                 310                 315                 320 


Gln Pro Ser Leu Ala Val Thr Leu Val Asp Asn His Asp Thr Gln Pro 
                325                 330                 335     


Gly Gln Ser Leu Gln Ser Trp Val Glu Pro Trp Phe Lys Pro Leu Ala 
            340                 345                 350         


Tyr Ala Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr 
        355                 360                 365             


Gly Asp Tyr Tyr Gly Ile Pro Lys Tyr Asn Ile Pro Gly Leu Lys Ser 
    370                 375                 380                 


Lys Ile Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr 
385                 390                 395                 400 


Gln Arg Asp Tyr Ile Asp His Gln Asp Ile Ile Gly Trp Thr Arg Glu 
                405                 410                 415     


Gly Ile Asp Thr Lys Pro Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp 
            420                 425                 430         


Gly Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Lys His Ala Gly 
        435                 440                 445             


Lys Val Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile 
    450                 455                 460                 


Asn Ala Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser 
465                 470                 475                 480 


Ile Trp Val Ala Lys 
                485 


<210>  57
<211>  485
<212>  PRT
<213>  Artifical Sequence

<400>  57

Asn Thr Ala Pro Val Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Asp 
1               5                   10                  15      


Leu Pro Asn Asp Gly Thr Leu Trp Thr Lys Val Lys Asn Glu Ala Thr 
            20                  25                  30          


Asn Leu Phe Ser Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Gln Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Ile Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Thr Gln Tyr Ile Gln Ala Ile Gln Ala Ala Lys Ala Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Arg Met Gly Ala Asp 
            100                 105                 110         


Ala Thr Glu Thr Ile Ser Ala Val Glu Val Asn Pro Ser Asn Arg Asn 
        115                 120                 125             


Gln Val Thr Ser Gly Ala Tyr Asn Ile Ser Ala Trp Thr Asp Phe Glu 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp His Ser Tyr 
145                 150                 155                 160 


Tyr Phe Asp Gly Val Asp Trp Asp Gln Ser Arg Gln Leu Ser Gly Lys 
                165                 170                 175     


Ile Tyr Gln Ile Gln Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Asp 
            180                 185                 190         


Ser Glu Asn Gly Asn Tyr Asp Tyr Leu Met Gly Ala Asp Ile Asp Met 
        195                 200                 205             


Asp His Pro Glu Val Val Thr Glu Leu Lys Asn Trp Gly Thr Trp Tyr 
    210                 215                 220                 


Val Asn Thr Thr Asn Ile Asp Gly Phe Arg Leu Asp Ala Val Lys His 
225                 230                 235                 240 


Ile Lys Tyr Ser Phe Phe Pro Asp Trp Leu Thr Tyr Val Arg Asn Gln 
                245                 250                 255     


Thr Gly Lys Asn Leu Phe Ala Val Gly Glu Phe Trp Ser Tyr Asp Val 
            260                 265                 270         


Asn Lys Leu His Asn Tyr Ile Thr Lys Thr Asn Gly Ser Met Ser Leu 
        275                 280                 285             


Phe Asp Ala Pro Leu His Asn Asn Phe Tyr Thr Ala Ser Lys Ser Ser 
    290                 295                 300                 


Gly Tyr Phe Asp Met Arg Tyr Leu Leu Asn Asn Thr Leu Met Lys Asp 
305                 310                 315                 320 


Gln Pro Ser Leu Ala Val Thr Leu Val Asp Asn His Asp Thr Gln Pro 
                325                 330                 335     


Gly Gln Ser Leu Gln Ser Trp Val Glu Pro Trp Phe Lys Pro Leu Ala 
            340                 345                 350         


Tyr Ala Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr 
        355                 360                 365             


Gly Asp Tyr Tyr Gly Ile Pro Lys Tyr Asn Ile Pro Gly Leu Lys Ser 
    370                 375                 380                 


Lys Ile Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr 
385                 390                 395                 400 


Gln Arg Asp Tyr Ile Asp His Gln Asp Ile Ile Gly Trp Thr Arg Glu 
                405                 410                 415     


Gly Ile Asp Thr Lys Pro Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp 
            420                 425                 430         


Gly Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Lys His Ala Gly 
        435                 440                 445             


Lys Val Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile 
    450                 455                 460                 


Asn Ala Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser 
465                 470                 475                 480 


Ile Trp Val Ala Lys 
                485 


<210>  58
<211>  484
<212>  PRT
<213>  Artifical Sequence

<400>  58

Asn Thr Ala Pro Val Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Asp 
1               5                   10                  15      


Leu Pro Asn Asp Gly Thr Leu Trp Thr Lys Val Lys Asn Glu Ala Thr 
            20                  25                  30          


Asn Leu Phe Ser Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Gln Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Ile Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Thr Gln Tyr Ile Gln Ala Ile Gln Ala Ala Lys Ala Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Lys Ala Gly Ala Asp 
            100                 105                 110         


Ala Thr Glu Asp Val Thr Ala Val Glu Val Asn Pro Ala Asn Arg Asn 
        115                 120                 125             


Gln Glu Thr Ser Glu Glu Tyr Gln Ile Lys Ala Trp Thr Asp Phe Arg 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Asp Phe Lys Trp His Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Ala Asp Trp Asp Glu Ser Arg Lys Ile Ser Arg Ile 
                165                 170                 175     


Phe Lys Phe Arg Gly Glu Gly Lys Ala Trp Asp Trp Glu Val Ser Ser 
            180                 185                 190         


Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Val Asp Met Asp 
        195                 200                 205             


His Pro Glu Val Val Thr Glu Leu Lys Asn Trp Gly Thr Trp Tyr Val 
    210                 215                 220                 


Asn Thr Thr Asn Ile Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile 
225                 230                 235                 240 


Lys Tyr Ser Phe Phe Pro Asp Trp Leu Thr Tyr Val Arg Asn Gln Thr 
                245                 250                 255     


Gly Lys Asn Leu Phe Ala Val Gly Glu Phe Trp Ser Tyr Asp Val Asn 
            260                 265                 270         


Lys Leu His Asn Tyr Ile Thr Lys Thr Asn Gly Ser Met Ser Leu Phe 
        275                 280                 285             


Asp Ala Pro Leu His Asn Asn Phe Tyr Thr Ala Ser Lys Ser Ser Gly 
    290                 295                 300                 


Tyr Phe Asp Met Arg Tyr Leu Leu Asn Asn Thr Leu Met Lys Asp Gln 
305                 310                 315                 320 


Pro Ser Leu Ala Val Thr Leu Val Asp Asn His Asp Thr Gln Pro Gly 
                325                 330                 335     


Gln Ser Leu Gln Ser Trp Val Glu Pro Trp Phe Lys Pro Leu Ala Tyr 
            340                 345                 350         


Ala Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr Gly 
        355                 360                 365             


Asp Tyr Tyr Gly Ile Pro Lys Tyr Asn Ile Pro Gly Leu Lys Ser Lys 
    370                 375                 380                 


Ile Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr Gln 
385                 390                 395                 400 


Arg Asp Tyr Ile Asp His Gln Asp Ile Ile Gly Trp Thr Arg Glu Gly 
                405                 410                 415     


Ile Asp Thr Lys Pro Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly 
            420                 425                 430         


Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Lys His Ala Gly Lys 
        435                 440                 445             


Val Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile Asn 
    450                 455                 460                 


Ala Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser Ile 
465                 470                 475                 480 


Trp Val Ala Lys 
                


<210>  59
<211>  482
<212>  PRT
<213>  Artifical Sequence

<400>  59

Asn Thr Ala Pro Val Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Asp 
1               5                   10                  15      


Leu Pro Asn Asp Gly Thr Leu Trp Thr Lys Val Lys Asn Glu Ala Thr 
            20                  25                  30          


Asn Leu Phe Ser Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Gln Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Ile Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Thr Gln Tyr Ile Gln Ala Ile Gln Ala Ala Lys Ala Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Lys Gly Gly Ala Asp 
            100                 105                 110         


Ala Thr Glu Asp Val Thr Ala Val Glu Val Asp Pro Ala Asp Arg Asn 
        115                 120                 125             


Arg Val Ile Ser Gly Glu His Leu Ile Lys Ala Trp Thr His Phe His 
    130                 135                 140                 


Phe Pro Gly Arg Gly Ser Thr Tyr Ser Asp Phe Lys Trp His Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Glu Ser Arg Lys Leu Asn Arg Ile 
                165                 170                 175     


Tyr Lys Phe Gln Gly Lys Ala Trp Asp Trp Glu Val Ser Asn Glu Phe 
            180                 185                 190         


Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Ile Asp Met Asp His Pro 
        195                 200                 205             


Glu Val Val Thr Glu Leu Lys Asn Trp Gly Thr Trp Tyr Val Asn Thr 
    210                 215                 220                 


Thr Asn Ile Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile Lys Tyr 
225                 230                 235                 240 


Ser Phe Phe Pro Asp Trp Leu Thr Tyr Val Arg Asn Gln Thr Gly Lys 
                245                 250                 255     


Asn Leu Phe Ala Val Gly Glu Phe Trp Ser Tyr Asp Val Asn Lys Leu 
            260                 265                 270         


His Asn Tyr Ile Thr Lys Thr Asn Gly Ser Met Ser Leu Phe Asp Ala 
        275                 280                 285             


Pro Leu His Asn Asn Phe Tyr Thr Ala Ser Lys Ser Ser Gly Tyr Phe 
    290                 295                 300                 


Asp Met Arg Tyr Leu Leu Asn Asn Thr Leu Met Lys Asp Gln Pro Ser 
305                 310                 315                 320 


Leu Ala Val Thr Leu Val Asp Asn His Asp Thr Gln Pro Gly Gln Ser 
                325                 330                 335     


Leu Gln Ser Trp Val Glu Pro Trp Phe Lys Pro Leu Ala Tyr Ala Phe 
            340                 345                 350         


Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr Gly Asp Tyr 
        355                 360                 365             


Tyr Gly Ile Pro Lys Tyr Asn Ile Pro Gly Leu Lys Ser Lys Ile Asp 
    370                 375                 380                 


Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr Gln Arg Asp 
385                 390                 395                 400 


Tyr Ile Asp His Gln Asp Ile Ile Gly Trp Thr Arg Glu Gly Ile Asp 
                405                 410                 415     


Thr Lys Pro Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly Pro Gly 
            420                 425                 430         


Gly Ser Lys Trp Met Tyr Val Gly Lys Lys His Ala Gly Lys Val Phe 
        435                 440                 445             


Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile Asn Ala Asp 
    450                 455                 460                 


Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser Ile Trp Val 
465                 470                 475                 480 


Ala Lys 
        


<210>  60
<211>  484
<212>  PRT
<213>  Artifical Sequence

<400>  60

Asn Thr Ala Pro Val Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Asp 
1               5                   10                  15      


Leu Pro Asn Asp Gly Thr Leu Trp Thr Lys Val Lys Asn Glu Ala Thr 
            20                  25                  30          


Asn Leu Phe Ser Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Gln Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Ile Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Thr Gln Tyr Ile Gln Ala Ile Gln Ala Ala Lys Ala Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Lys Ala Gly Ala Asp 
            100                 105                 110         


Tyr Thr Glu Asn Val Thr Ala Val Glu Val Asn Pro Ser Asn Arg Asn 
        115                 120                 125             


Gln Glu Thr Ser Gly Glu Tyr Asn Ile Gln Ala Trp Thr Gly Phe Asn 
    130                 135                 140                 


Phe Pro Gly Arg Gly Thr Thr Tyr Ser Asn Phe Lys Trp Gln Trp Phe 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Gln Ser Arg Ser Leu Ser Arg Ile 
                165                 170                 175     


Phe Lys Phe Arg Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Ser Ser 
            180                 185                 190         


Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Ile Asp Met Asp 
        195                 200                 205             


His Pro Glu Val Val Thr Glu Leu Lys Asn Trp Gly Thr Trp Tyr Val 
    210                 215                 220                 


Asn Thr Thr Asn Ile Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile 
225                 230                 235                 240 


Lys Tyr Ser Phe Phe Pro Asp Trp Leu Thr Tyr Val Arg Asn Gln Thr 
                245                 250                 255     


Gly Lys Asn Leu Phe Ala Val Gly Glu Phe Trp Ser Tyr Asp Val Asn 
            260                 265                 270         


Lys Leu His Asn Tyr Ile Thr Lys Thr Asn Gly Ser Met Ser Leu Phe 
        275                 280                 285             


Asp Ala Pro Leu His Asn Asn Phe Tyr Thr Ala Ser Lys Ser Ser Gly 
    290                 295                 300                 


Tyr Phe Asp Met Arg Tyr Leu Leu Asn Asn Thr Leu Met Lys Asp Gln 
305                 310                 315                 320 


Pro Ser Leu Ala Val Thr Leu Val Asp Asn His Asp Thr Gln Pro Gly 
                325                 330                 335     


Gln Ser Leu Gln Ser Trp Val Glu Pro Trp Phe Lys Pro Leu Ala Tyr 
            340                 345                 350         


Ala Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr Gly 
        355                 360                 365             


Asp Tyr Tyr Gly Ile Pro Lys Tyr Asn Ile Pro Gly Leu Lys Ser Lys 
    370                 375                 380                 


Ile Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr Gln 
385                 390                 395                 400 


Arg Asp Tyr Ile Asp His Gln Asp Ile Ile Gly Trp Thr Arg Glu Gly 
                405                 410                 415     


Ile Asp Thr Lys Pro Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly 
            420                 425                 430         


Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Lys His Ala Gly Lys 
        435                 440                 445             


Val Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile Asn 
    450                 455                 460                 


Ala Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser Ile 
465                 470                 475                 480 


Trp Val Ala Lys 
                


<210>  61
<211>  484
<212>  PRT
<213>  Artifiical Sequence

<400>  61

Asn Thr Ala Pro Val Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Asp 
1               5                   10                  15      


Leu Pro Asn Asp Gly Thr Leu Trp Thr Lys Val Lys Asn Glu Ala Thr 
            20                  25                  30          


Asn Leu Phe Ser Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Gln Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Ile Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Thr Gln Tyr Ile Gln Ala Ile Gln Ala Ala Lys Ala Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asp His Lys Gly Gly Ala Asp 
            100                 105                 110         


Gly Thr Glu Trp Val Asp Ala Val Glu Val Asn Pro Ser Asp Arg Asn 
        115                 120                 125             


Gln Glu Ile Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Val Asp Trp Asp Glu Ser Arg Lys Leu Ser Arg Ile 
                165                 170                 175     


Tyr Lys Phe Arg Gly Ile Gly Lys Ala Trp Asp Trp Glu Val Asp Thr 
            180                 185                 190         


Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Leu Asp Met Asp 
        195                 200                 205             


His Pro Glu Val Val Thr Glu Leu Lys Asn Trp Gly Thr Trp Tyr Val 
    210                 215                 220                 


Asn Thr Thr Asn Ile Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile 
225                 230                 235                 240 


Lys Tyr Ser Phe Phe Pro Asp Trp Leu Thr Tyr Val Arg Asn Gln Thr 
                245                 250                 255     


Gly Lys Asn Leu Phe Ala Val Gly Glu Phe Trp Ser Tyr Asp Val Asn 
            260                 265                 270         


Lys Leu His Asn Tyr Ile Thr Lys Thr Asn Gly Ser Met Ser Leu Phe 
        275                 280                 285             


Asp Ala Pro Leu His Asn Asn Phe Tyr Thr Ala Ser Lys Ser Ser Gly 
    290                 295                 300                 


Tyr Phe Asp Met Arg Tyr Leu Leu Asn Asn Thr Leu Met Lys Asp Gln 
305                 310                 315                 320 


Pro Ser Leu Ala Val Thr Leu Val Asp Asn His Asp Thr Gln Pro Gly 
                325                 330                 335     


Gln Ser Leu Gln Ser Trp Val Glu Pro Trp Phe Lys Pro Leu Ala Tyr 
            340                 345                 350         


Ala Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr Gly 
        355                 360                 365             


Asp Tyr Tyr Gly Ile Pro Lys Tyr Asn Ile Pro Gly Leu Lys Ser Lys 
    370                 375                 380                 


Ile Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr Gln 
385                 390                 395                 400 


Arg Asp Tyr Ile Asp His Gln Asp Ile Ile Gly Trp Thr Arg Glu Gly 
                405                 410                 415     


Ile Asp Thr Lys Pro Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly 
            420                 425                 430         


Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Lys His Ala Gly Lys 
        435                 440                 445             


Val Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile Asn 
    450                 455                 460                 


Ala Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser Ile 
465                 470                 475                 480 


Trp Val Ala Lys 
                


<210>  62
<211>  484
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  62

Asn Thr Ala Pro Val Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Asp 
1               5                   10                  15      


Leu Pro Asn Asp Gly Thr Leu Trp Thr Lys Val Lys Asn Glu Ala Thr 
            20                  25                  30          


Asn Leu Phe Ser Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Gln Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Ile Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Thr Gln Tyr Ile Gln Ala Ile Gln Ala Ala Lys Ala Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Lys Ala Gly Ala Asp 
            100                 105                 110         


Gly Thr Glu Leu Val Asp Ala Val Glu Val Asn Pro Ser Asp Arg Asn 
        115                 120                 125             


Gln Glu Ile Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Glu Ser Arg Lys Leu Asn Arg Ile 
                165                 170                 175     


Tyr Lys Phe Arg Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Asp Thr 
            180                 185                 190         


Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Leu Asp Met Asp 
        195                 200                 205             


His Pro Glu Val Val Thr Glu Leu Lys Asn Trp Gly Thr Trp Tyr Val 
    210                 215                 220                 


Asn Thr Thr Asn Ile Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile 
225                 230                 235                 240 


Lys Tyr Ser Phe Phe Pro Asp Trp Leu Thr Tyr Val Arg Asn Gln Thr 
                245                 250                 255     


Gly Lys Asn Leu Phe Ala Val Gly Glu Phe Trp Ser Tyr Asp Val Asn 
            260                 265                 270         


Lys Leu His Asn Tyr Ile Thr Lys Thr Asn Gly Ser Met Ser Leu Phe 
        275                 280                 285             


Asp Ala Pro Leu His Asn Asn Phe Tyr Thr Ala Ser Lys Ser Ser Gly 
    290                 295                 300                 


Tyr Phe Asp Met Arg Tyr Leu Leu Asn Asn Thr Leu Met Lys Asp Gln 
305                 310                 315                 320 


Pro Ser Leu Ala Val Thr Leu Val Asp Asn His Asp Thr Gln Pro Gly 
                325                 330                 335     


Gln Ser Leu Gln Ser Trp Val Glu Pro Trp Phe Lys Pro Leu Ala Tyr 
            340                 345                 350         


Ala Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr Gly 
        355                 360                 365             


Asp Tyr Tyr Gly Ile Pro Lys Tyr Asn Ile Pro Gly Leu Lys Ser Lys 
    370                 375                 380                 


Ile Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr Gln 
385                 390                 395                 400 


Arg Asp Tyr Ile Asp His Gln Asp Ile Ile Gly Trp Thr Arg Glu Gly 
                405                 410                 415     


Ile Asp Thr Lys Pro Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly 
            420                 425                 430         


Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Lys His Ala Gly Lys 
        435                 440                 445             


Val Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile Asn 
    450                 455                 460                 


Ala Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser Ile 
465                 470                 475                 480 


Trp Val Ala Lys 
                


<210>  63
<211>  484
<212>  PRT
<213>  Artifical Sequence

<400>  63

Asn Thr Ala Pro Val Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Asp 
1               5                   10                  15      


Leu Pro Asn Asp Gly Thr Leu Trp Thr Lys Val Lys Asn Glu Ala Thr 
            20                  25                  30          


Asn Leu Phe Ser Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Gln Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Ile Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Thr Gln Tyr Ile Gln Ala Ile Gln Ala Ala Lys Ala Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Lys Ala Gly Ala Asp 
            100                 105                 110         


Gly Thr Glu Phe Val Asp Ala Val Glu Val Asn Pro Ser Asn Arg Asn 
        115                 120                 125             


Gln Glu Thr Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Glu Ser Arg Lys Leu Asn Arg Val 
                165                 170                 175     


Tyr Lys Phe Arg Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Asp Thr 
            180                 185                 190         


Glu Asn Gly Asn Tyr Asp Tyr Leu Met Phe Ala Asp Leu Asp Met Asp 
        195                 200                 205             


His Pro Glu Val Val Thr Glu Leu Lys Asn Trp Gly Thr Trp Tyr Val 
    210                 215                 220                 


Asn Thr Thr Asn Ile Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile 
225                 230                 235                 240 


Lys Tyr Ser Phe Phe Pro Asp Trp Leu Thr Tyr Val Arg Asn Gln Thr 
                245                 250                 255     


Gly Lys Asn Leu Phe Ala Val Gly Glu Phe Trp Ser Tyr Asp Val Asn 
            260                 265                 270         


Lys Leu His Asn Tyr Ile Thr Lys Thr Asn Gly Ser Met Ser Leu Phe 
        275                 280                 285             


Asp Ala Pro Leu His Asn Asn Phe Tyr Thr Ala Ser Lys Ser Ser Gly 
    290                 295                 300                 


Tyr Phe Asp Met Arg Tyr Leu Leu Asn Asn Thr Leu Met Lys Asp Gln 
305                 310                 315                 320 


Pro Ser Leu Ala Val Thr Leu Val Asp Asn His Asp Thr Gln Pro Gly 
                325                 330                 335     


Gln Ser Leu Gln Ser Trp Val Glu Pro Trp Phe Lys Pro Leu Ala Tyr 
            340                 345                 350         


Ala Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr Gly 
        355                 360                 365             


Asp Tyr Tyr Gly Ile Pro Lys Tyr Asn Ile Pro Gly Leu Lys Ser Lys 
    370                 375                 380                 


Ile Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr Gln 
385                 390                 395                 400 


Arg Asp Tyr Ile Asp His Gln Asp Ile Ile Gly Trp Thr Arg Glu Gly 
                405                 410                 415     


Ile Asp Thr Lys Pro Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly 
            420                 425                 430         


Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Lys His Ala Gly Lys 
        435                 440                 445             


Val Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile Asn 
    450                 455                 460                 


Ala Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser Ile 
465                 470                 475                 480 


Trp Val Ala Lys 
                


<210>  64
<211>  483
<212>  PRT
<213>  Artifiical Sequence

<400>  64

Asn Thr Ala Pro Val Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Asp 
1               5                   10                  15      


Leu Pro Asn Asp Gly Thr Leu Trp Thr Lys Val Lys Asn Glu Ala Thr 
            20                  25                  30          


Asn Leu Phe Ser Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Gln Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Ile Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Thr Gln Tyr Ile Gln Ala Ile Gln Ala Ala Lys Ala Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Lys Ala Gly Ala Asp 
            100                 105                 110         


Gly Thr Glu Phe Val Asp Ala Val Glu Val Asp Pro Ser Asn Arg Asn 
        115                 120                 125             


Gln Glu Thr Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Glu Ser Arg Lys Leu Asn Arg Ile 
                165                 170                 175     


Tyr Lys Phe Ser Thr Gly Lys Ala Trp Asp Trp Glu Val Asp Thr Glu 
            180                 185                 190         


Asn Gly Asn Tyr Asp Tyr Leu Met Phe Ala Asp Leu Asp Met Asp His 
        195                 200                 205             


Pro Glu Val Val Thr Glu Leu Lys Asn Trp Gly Thr Trp Tyr Val Asn 
    210                 215                 220                 


Thr Thr Asn Ile Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile Lys 
225                 230                 235                 240 


Tyr Ser Phe Phe Pro Asp Trp Leu Thr Tyr Val Arg Asn Gln Thr Gly 
                245                 250                 255     


Lys Asn Leu Phe Ala Val Gly Glu Phe Trp Ser Tyr Asp Val Asn Lys 
            260                 265                 270         


Leu His Asn Tyr Ile Thr Lys Thr Asn Gly Ser Met Ser Leu Phe Asp 
        275                 280                 285             


Ala Pro Leu His Asn Asn Phe Tyr Thr Ala Ser Lys Ser Ser Gly Tyr 
    290                 295                 300                 


Phe Asp Met Arg Tyr Leu Leu Asn Asn Thr Leu Met Lys Asp Gln Pro 
305                 310                 315                 320 


Ser Leu Ala Val Thr Leu Val Asp Asn His Asp Thr Gln Pro Gly Gln 
                325                 330                 335     


Ser Leu Gln Ser Trp Val Glu Pro Trp Phe Lys Pro Leu Ala Tyr Ala 
            340                 345                 350         


Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr Gly Asp 
        355                 360                 365             


Tyr Tyr Gly Ile Pro Lys Tyr Asn Ile Pro Gly Leu Lys Ser Lys Ile 
    370                 375                 380                 


Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr Gln Arg 
385                 390                 395                 400 


Asp Tyr Ile Asp His Gln Asp Ile Ile Gly Trp Thr Arg Glu Gly Ile 
                405                 410                 415     


Asp Thr Lys Pro Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly Pro 
            420                 425                 430         


Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Lys His Ala Gly Lys Val 
        435                 440                 445             


Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile Asn Ala 
    450                 455                 460                 


Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser Ile Trp 
465                 470                 475                 480 


Val Ala Lys 
            


<210>  65
<211>  484
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  65

Asn Thr Ala Pro Val Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Asp 
1               5                   10                  15      


Leu Pro Asn Asp Gly Thr Leu Trp Thr Lys Val Lys Asn Glu Ala Thr 
            20                  25                  30          


Asn Leu Phe Ser Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Gln Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Ile Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Thr Gln Tyr Ile Gln Ala Ile Gln Ala Ala Lys Ala Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Lys Ala Gly Ala Asp 
            100                 105                 110         


Ala Thr Glu Trp Val Asp Ala Val Glu Val Asn Pro Ser Asn Arg Asn 
        115                 120                 125             


Gln Glu Val Ser Gly Thr Tyr Lys Ile Gln Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Gln Ser Arg Gln Leu Asn Arg Ile 
                165                 170                 175     


Tyr Lys Phe Arg Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Asp Thr 
            180                 185                 190         


Glu Asn Gly Asn Tyr Asp Tyr Leu Met Phe Ala Asp Leu Asp Met Asp 
        195                 200                 205             


His Pro Glu Val Val Thr Glu Leu Lys Asn Trp Gly Thr Trp Tyr Val 
    210                 215                 220                 


Asn Thr Thr Asn Ile Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile 
225                 230                 235                 240 


Lys Tyr Ser Phe Phe Pro Asp Trp Leu Thr Tyr Val Arg Asn Gln Thr 
                245                 250                 255     


Gly Lys Asn Leu Phe Ala Val Gly Glu Phe Trp Ser Tyr Asp Val Asn 
            260                 265                 270         


Lys Leu His Asn Tyr Ile Thr Lys Thr Asn Gly Ser Met Ser Leu Phe 
        275                 280                 285             


Asp Ala Pro Leu His Asn Asn Phe Tyr Thr Ala Ser Lys Ser Ser Gly 
    290                 295                 300                 


Tyr Phe Asp Met Arg Tyr Leu Leu Asn Asn Thr Leu Met Lys Asp Gln 
305                 310                 315                 320 


Pro Ser Leu Ala Val Thr Leu Val Asp Asn His Asp Thr Gln Pro Gly 
                325                 330                 335     


Gln Ser Leu Gln Ser Trp Val Glu Pro Trp Phe Lys Pro Leu Ala Tyr 
            340                 345                 350         


Ala Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr Gly 
        355                 360                 365             


Asp Tyr Tyr Gly Ile Pro Lys Tyr Asn Ile Pro Gly Leu Lys Ser Lys 
    370                 375                 380                 


Ile Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr Gln 
385                 390                 395                 400 


Arg Asp Tyr Ile Asp His Gln Asp Ile Ile Gly Trp Thr Arg Glu Gly 
                405                 410                 415     


Ile Asp Thr Lys Pro Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly 
            420                 425                 430         


Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Lys His Ala Gly Lys 
        435                 440                 445             


Val Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile Asn 
    450                 455                 460                 


Ala Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser Ile 
465                 470                 475                 480 


Trp Val Ala Lys 
                


<210>  66
<211>  484
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  66

Asn Thr Ala Pro Val Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Asp 
1               5                   10                  15      


Leu Pro Asn Asp Gly Thr Leu Trp Thr Lys Val Lys Asn Glu Ala Thr 
            20                  25                  30          


Asn Leu Phe Ser Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Gln Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Ile Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Thr Gln Tyr Ile Gln Ala Ile Gln Ala Ala Lys Ala Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Lys Ala Gly Ala Asp 
            100                 105                 110         


Ser Thr Glu Trp Val Asp Ala Val Glu Val Asn Pro Ser Asn Arg Asn 
        115                 120                 125             


Gln Glu Thr Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Glu Ser Arg Lys Leu Asn Arg Ile 
                165                 170                 175     


Tyr Lys Phe Arg Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Asp Thr 
            180                 185                 190         


Glu Asn Gly Asn Tyr Asp Tyr Leu Met Phe Ala Asp Leu Asp Met Asp 
        195                 200                 205             


His Pro Glu Val Val Thr Glu Leu Lys Asn Trp Gly Thr Trp Tyr Val 
    210                 215                 220                 


Asn Thr Thr Asn Ile Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile 
225                 230                 235                 240 


Lys Tyr Ser Phe Phe Pro Asp Trp Leu Thr Tyr Val Arg Asn Gln Thr 
                245                 250                 255     


Gly Lys Asn Leu Phe Ala Val Gly Glu Phe Trp Ser Tyr Asp Val Asn 
            260                 265                 270         


Lys Leu His Asn Tyr Ile Thr Lys Thr Asn Gly Ser Met Ser Leu Phe 
        275                 280                 285             


Asp Ala Pro Leu His Asn Asn Phe Tyr Thr Ala Ser Lys Ser Ser Gly 
    290                 295                 300                 


Tyr Phe Asp Met Arg Tyr Leu Leu Asn Asn Thr Leu Met Lys Asp Gln 
305                 310                 315                 320 


Pro Ser Leu Ala Val Thr Leu Val Asp Asn His Asp Thr Gln Pro Gly 
                325                 330                 335     


Gln Ser Leu Gln Ser Trp Val Glu Pro Trp Phe Lys Pro Leu Ala Tyr 
            340                 345                 350         


Ala Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr Gly 
        355                 360                 365             


Asp Tyr Tyr Gly Ile Pro Lys Tyr Asn Ile Pro Gly Leu Lys Ser Lys 
    370                 375                 380                 


Ile Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr Gln 
385                 390                 395                 400 


Arg Asp Tyr Ile Asp His Gln Asp Ile Ile Gly Trp Thr Arg Glu Gly 
                405                 410                 415     


Ile Asp Thr Lys Pro Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly 
            420                 425                 430         


Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Lys His Ala Gly Lys 
        435                 440                 445             


Val Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile Asn 
    450                 455                 460                 


Ala Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser Ile 
465                 470                 475                 480 


Trp Val Ala Lys 
                


<210>  67
<211>  485
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  67

Asn Thr Ala Pro Val Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Asp 
1               5                   10                  15      


Leu Pro Asn Asp Gly Thr Leu Trp Thr Lys Val Lys Asn Glu Ala Thr 
            20                  25                  30          


Asn Leu Phe Ser Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Gln Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Ile Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Thr Gln Tyr Ile Gln Ala Ile Gln Ala Ala Lys Ala Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Lys Gly Gly Ala Asp 
            100                 105                 110         


Phe Thr Glu Arg Val Gln Ala Val Glu Val Asn Pro Gln Asn Arg Asn 
        115                 120                 125             


Gln Glu Val Ser Gly Thr Tyr Gln Ile Glu Ala Trp Thr Gly Phe Asn 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Gln His Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Gln Ser Arg Gln Leu Ala Asn Arg 
                165                 170                 175     


Ile Tyr Lys Phe Arg Gly Asp Gly Lys Ala Trp Asp Trp Glu Val Asp 
            180                 185                 190         


Thr Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Val Asp Met 
        195                 200                 205             


Asp His Pro Glu Val Val Thr Glu Leu Lys Asn Trp Gly Thr Trp Tyr 
    210                 215                 220                 


Val Asn Thr Thr Asn Ile Asp Gly Phe Arg Leu Asp Ala Val Lys His 
225                 230                 235                 240 


Ile Lys Tyr Ser Phe Phe Pro Asp Trp Leu Thr Tyr Val Arg Asn Gln 
                245                 250                 255     


Thr Gly Lys Asn Leu Phe Ala Val Gly Glu Phe Trp Ser Tyr Asp Val 
            260                 265                 270         


Asn Lys Leu His Asn Tyr Ile Thr Lys Thr Asn Gly Ser Met Ser Leu 
        275                 280                 285             


Phe Asp Ala Pro Leu His Asn Asn Phe Tyr Thr Ala Ser Lys Ser Ser 
    290                 295                 300                 


Gly Tyr Phe Asp Met Arg Tyr Leu Leu Asn Asn Thr Leu Met Lys Asp 
305                 310                 315                 320 


Gln Pro Ser Leu Ala Val Thr Leu Val Asp Asn His Asp Thr Gln Pro 
                325                 330                 335     


Gly Gln Ser Leu Gln Ser Trp Val Glu Pro Trp Phe Lys Pro Leu Ala 
            340                 345                 350         


Tyr Ala Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr 
        355                 360                 365             


Gly Asp Tyr Tyr Gly Ile Pro Lys Tyr Asn Ile Pro Gly Leu Lys Ser 
    370                 375                 380                 


Lys Ile Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr 
385                 390                 395                 400 


Gln Arg Asp Tyr Ile Asp His Gln Asp Ile Ile Gly Trp Thr Arg Glu 
                405                 410                 415     


Gly Ile Asp Thr Lys Pro Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp 
            420                 425                 430         


Gly Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Lys His Ala Gly 
        435                 440                 445             


Lys Val Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile 
    450                 455                 460                 


Asn Ala Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser 
465                 470                 475                 480 


Ile Trp Val Ala Lys 
                485 


<210>  68
<211>  485
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  68

Asn Thr Ala Pro Val Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Asp 
1               5                   10                  15      


Leu Pro Asn Asp Gly Thr Leu Trp Thr Lys Val Lys Asn Glu Ala Thr 
            20                  25                  30          


Asn Leu Phe Ser Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Gln Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Ile Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Thr Gln Tyr Ile Gln Ala Ile Gln Ala Ala Lys Ala Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Lys Gly Gly Ala Asp 
            100                 105                 110         


Ala Thr Glu Asn Val Leu Ala Val Glu Val Asn Pro Asn Asn Arg Asn 
        115                 120                 125             


Gln Glu Ile Ser Gly Asp Tyr Thr Ile Glu Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Asp Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Val Asp Trp Asp Gln Ser Arg Gln Phe Gln Asn Arg 
                165                 170                 175     


Ile Tyr Lys Phe Arg Gly Asp Gly Lys Ala Trp Asp Trp Glu Val Asp 
            180                 185                 190         


Ser Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Val Asp Met 
        195                 200                 205             


Asp His Pro Glu Val Val Thr Glu Leu Lys Asn Trp Gly Thr Trp Tyr 
    210                 215                 220                 


Val Asn Thr Thr Asn Ile Asp Gly Phe Arg Leu Asp Ala Val Lys His 
225                 230                 235                 240 


Ile Lys Tyr Ser Phe Phe Pro Asp Trp Leu Thr Tyr Val Arg Asn Gln 
                245                 250                 255     


Thr Gly Lys Asn Leu Phe Ala Val Gly Glu Phe Trp Ser Tyr Asp Val 
            260                 265                 270         


Asn Lys Leu His Asn Tyr Ile Thr Lys Thr Asn Gly Ser Met Ser Leu 
        275                 280                 285             


Phe Asp Ala Pro Leu His Asn Asn Phe Tyr Thr Ala Ser Lys Ser Ser 
    290                 295                 300                 


Gly Tyr Phe Asp Met Arg Tyr Leu Leu Asn Asn Thr Leu Met Lys Asp 
305                 310                 315                 320 


Gln Pro Ser Leu Ala Val Thr Leu Val Asp Asn His Asp Thr Gln Pro 
                325                 330                 335     


Gly Gln Ser Leu Gln Ser Trp Val Glu Pro Trp Phe Lys Pro Leu Ala 
            340                 345                 350         


Tyr Ala Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr 
        355                 360                 365             


Gly Asp Tyr Tyr Gly Ile Pro Lys Tyr Asn Ile Pro Gly Leu Lys Ser 
    370                 375                 380                 


Lys Ile Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr 
385                 390                 395                 400 


Gln Arg Asp Tyr Ile Asp His Gln Asp Ile Ile Gly Trp Thr Arg Glu 
                405                 410                 415     


Gly Ile Asp Thr Lys Pro Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp 
            420                 425                 430         


Gly Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Lys His Ala Gly 
        435                 440                 445             


Lys Val Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile 
    450                 455                 460                 


Asn Ala Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser 
465                 470                 475                 480 


Ile Trp Val Ala Lys 
                485 


<210>  69
<211>  485
<212>  PRT
<213>  Artifiical Sequence

<400>  69

Asn Thr Ala Pro Val Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Asp 
1               5                   10                  15      


Leu Pro Asn Asp Gly Thr Leu Trp Thr Lys Val Lys Asn Glu Ala Thr 
            20                  25                  30          


Asn Leu Phe Ser Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Gln Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Ile Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Thr Gln Tyr Ile Gln Ala Ile Gln Ala Ala Lys Ala Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Lys Gly Gly Ala Asp 
            100                 105                 110         


Ala Thr Glu Met Val Arg Ala Val Glu Val Asn Pro Asn Asn Arg Asn 
        115                 120                 125             


Gln Glu Val Ser Gly Glu Tyr Thr Ile Glu Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr His Ser Asn Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Val Asp Trp Asp Gln Ser Arg Lys Leu Asn Asn Arg 
                165                 170                 175     


Ile Tyr Lys Phe Arg Gly Asp Gly Lys Gly Trp Asp Trp Glu Val Asp 
            180                 185                 190         


Thr Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Ile Asp Met 
        195                 200                 205             


Asp His Pro Glu Val Val Thr Glu Leu Lys Asn Trp Gly Thr Trp Tyr 
    210                 215                 220                 


Val Asn Thr Thr Asn Ile Asp Gly Phe Arg Leu Asp Ala Val Lys His 
225                 230                 235                 240 


Ile Lys Tyr Ser Phe Phe Pro Asp Trp Leu Thr Tyr Val Arg Asn Gln 
                245                 250                 255     


Thr Gly Lys Asn Leu Phe Ala Val Gly Glu Phe Trp Ser Tyr Asp Val 
            260                 265                 270         


Asn Lys Leu His Asn Tyr Ile Thr Lys Thr Asn Gly Ser Met Ser Leu 
        275                 280                 285             


Phe Asp Ala Pro Leu His Asn Asn Phe Tyr Thr Ala Ser Lys Ser Ser 
    290                 295                 300                 


Gly Tyr Phe Asp Met Arg Tyr Leu Leu Asn Asn Thr Leu Met Lys Asp 
305                 310                 315                 320 


Gln Pro Ser Leu Ala Val Thr Leu Val Asp Asn His Asp Thr Gln Pro 
                325                 330                 335     


Gly Gln Ser Leu Gln Ser Trp Val Glu Pro Trp Phe Lys Pro Leu Ala 
            340                 345                 350         


Tyr Ala Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr 
        355                 360                 365             


Gly Asp Tyr Tyr Gly Ile Pro Lys Tyr Asn Ile Pro Gly Leu Lys Ser 
    370                 375                 380                 


Lys Ile Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr 
385                 390                 395                 400 


Gln Arg Asp Tyr Ile Asp His Gln Asp Ile Ile Gly Trp Thr Arg Glu 
                405                 410                 415     


Gly Ile Asp Thr Lys Pro Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp 
            420                 425                 430         


Gly Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Lys His Ala Gly 
        435                 440                 445             


Lys Val Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile 
    450                 455                 460                 


Asn Ala Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser 
465                 470                 475                 480 


Ile Trp Val Ala Lys 
                485 


<210>  70
<211>  485
<212>  PRT
<213>  Artifiical Sequence

<400>  70

Asn Thr Ala Pro Val Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Asp 
1               5                   10                  15      


Leu Pro Asn Asp Gly Thr Leu Trp Thr Lys Val Lys Asn Glu Ala Thr 
            20                  25                  30          


Asn Leu Phe Ser Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Gln Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Ile Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Thr Gln Tyr Ile Gln Ala Ile Gln Ala Ala Lys Ala Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Lys Gly Gly Ala Asp 
            100                 105                 110         


Ala Thr Glu Met Val Arg Ala Val Glu Val Asn Pro Asn Asn Arg Asn 
        115                 120                 125             


Gln Glu Val Thr Gly Glu Tyr Thr Ile Glu Ala Trp Thr Arg Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr His Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Val Asp Trp Asp Gln Ser Arg Arg Leu Asn Asn Arg 
                165                 170                 175     


Ile Tyr Lys Phe Arg Gly His Gly Lys Ala Trp Asp Trp Glu Val Asp 
            180                 185                 190         


Thr Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Ile Asp Met 
        195                 200                 205             


Asp His Pro Glu Val Val Thr Glu Leu Lys Asn Trp Gly Thr Trp Tyr 
    210                 215                 220                 


Val Asn Thr Thr Asn Ile Asp Gly Phe Arg Leu Asp Ala Val Lys His 
225                 230                 235                 240 


Ile Lys Tyr Ser Phe Phe Pro Asp Trp Leu Thr Tyr Val Arg Asn Gln 
                245                 250                 255     


Thr Gly Lys Asn Leu Phe Ala Val Gly Glu Phe Trp Ser Tyr Asp Val 
            260                 265                 270         


Asn Lys Leu His Asn Tyr Ile Thr Lys Thr Asn Gly Ser Met Ser Leu 
        275                 280                 285             


Phe Asp Ala Pro Leu His Asn Asn Phe Tyr Thr Ala Ser Lys Ser Ser 
    290                 295                 300                 


Gly Tyr Phe Asp Met Arg Tyr Leu Leu Asn Asn Thr Leu Met Lys Asp 
305                 310                 315                 320 


Gln Pro Ser Leu Ala Val Thr Leu Val Asp Asn His Asp Thr Gln Pro 
                325                 330                 335     


Gly Gln Ser Leu Gln Ser Trp Val Glu Pro Trp Phe Lys Pro Leu Ala 
            340                 345                 350         


Tyr Ala Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr 
        355                 360                 365             


Gly Asp Tyr Tyr Gly Ile Pro Lys Tyr Asn Ile Pro Gly Leu Lys Ser 
    370                 375                 380                 


Lys Ile Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr 
385                 390                 395                 400 


Gln Arg Asp Tyr Ile Asp His Gln Asp Ile Ile Gly Trp Thr Arg Glu 
                405                 410                 415     


Gly Ile Asp Thr Lys Pro Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp 
            420                 425                 430         


Gly Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Lys His Ala Gly 
        435                 440                 445             


Lys Val Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile 
    450                 455                 460                 


Asn Ala Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser 
465                 470                 475                 480 


Ile Trp Val Ala Lys 
                485 


<210>  71
<211>  485
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  71

Asn Thr Ala Pro Val Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Asp 
1               5                   10                  15      


Leu Pro Asn Asp Gly Thr Leu Trp Thr Lys Val Lys Asn Glu Ala Ala 
            20                  25                  30          


Asn Leu Ser Ser Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Gln Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Ile Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Thr Gln Tyr Ile Gln Ala Ile Gln Ala Ala Lys Ala Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Arg Met Gly Ala Asp 
            100                 105                 110         


Ala Thr Glu Thr Ile Ser Ala Val Glu Val Asn Pro Ser Asn Arg Asn 
        115                 120                 125             


Gln Val Thr Ser Gly Ala Tyr Asn Ile Ser Ala Trp Thr Asp Phe Glu 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp His Ser Tyr 
145                 150                 155                 160 


Tyr Phe Asp Gly Val Asp Trp Asp Gln Ser Arg Gln Leu Ser Gly Lys 
                165                 170                 175     


Ile Tyr Gln Ile Gln Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Asp 
            180                 185                 190         


Ser Glu Asn Gly Asn Tyr Asp Tyr Leu Met Gly Ala Asp Ile Asp Met 
        195                 200                 205             


Asp His Pro Glu Val Val Ala Glu Leu Lys Asn Trp Gly Lys Trp Tyr 
    210                 215                 220                 


Val Asn Thr Thr Asn Val Asp Gly Phe Arg Leu Asp Ala Val Lys His 
225                 230                 235                 240 


Ile Lys Tyr Ser Phe Phe Pro Asp Trp Leu Ser Tyr Val Arg Asn Gln 
                245                 250                 255     


Thr Gly Lys Asn Leu Phe Ala Val Gly Glu Phe Trp Ser Tyr Asp Val 
            260                 265                 270         


Asn Lys Leu His Asn Tyr Ile Thr Lys Thr Asn Gly Thr Met Ser Leu 
        275                 280                 285             


Phe Asp Ala Pro Leu His Asn Asn Phe Tyr Ile Ala Ser Lys Ser Ser 
    290                 295                 300                 


Gly Tyr Phe Asp Met Arg Tyr Leu Leu Asn Asn Thr Leu Met Lys Asp 
305                 310                 315                 320 


Gln Pro Ala Leu Ala Val Thr Leu Val Asp Asn His Asp Thr Gln Pro 
                325                 330                 335     


Gly Gln Ser Leu Gln Ser Trp Val Glu Pro Trp Phe Lys Pro Leu Ala 
            340                 345                 350         


Tyr Ala Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr 
        355                 360                 365             


Gly Asp Tyr Tyr Gly Ile Pro Lys Tyr Asn Ile Pro Gly Leu Lys Ser 
    370                 375                 380                 


Lys Ile Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr 
385                 390                 395                 400 


Gln Arg Asp Tyr Ile Asp His Pro Asp Ile Ile Gly Trp Thr Arg Glu 
                405                 410                 415     


Gly Ile Asp Ala Lys Pro Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp 
            420                 425                 430         


Gly Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Lys His Ala Gly 
        435                 440                 445             


Lys Val Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile 
    450                 455                 460                 


Asn Ala Asp Gly Trp Gly Gln Phe Lys Val Asn Gly Gly Ser Val Ser 
465                 470                 475                 480 


Ile Trp Val Ala Lys 
                485 


<210>  72
<211>  484
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  72

Asn Thr Ala Pro Val Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Asp 
1               5                   10                  15      


Leu Pro Asn Asp Gly Thr Leu Trp Thr Lys Val Lys Asn Glu Ala Ala 
            20                  25                  30          


Asn Leu Ser Ser Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Gln Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Ile Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Thr Gln Tyr Ile Gln Ala Ile Gln Ala Ala Lys Ala Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Lys Ala Gly Ala Asp 
            100                 105                 110         


Ala Thr Glu Asp Val Thr Ala Val Glu Val Asn Pro Ala Asn Arg Asn 
        115                 120                 125             


Gln Glu Thr Ser Glu Glu Tyr Gln Ile Lys Ala Trp Thr Asp Phe Arg 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Asp Phe Lys Trp His Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Ala Asp Trp Asp Glu Ser Arg Lys Ile Ser Arg Ile 
                165                 170                 175     


Phe Lys Phe Arg Gly Glu Gly Lys Ala Trp Asp Trp Glu Val Ser Ser 
            180                 185                 190         


Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Val Asp Met Asp 
        195                 200                 205             


His Pro Glu Val Val Ala Glu Leu Lys Asn Trp Gly Lys Trp Tyr Val 
    210                 215                 220                 


Asn Thr Thr Asn Val Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile 
225                 230                 235                 240 


Lys Tyr Ser Phe Phe Pro Asp Trp Leu Ser Tyr Val Arg Asn Gln Thr 
                245                 250                 255     


Gly Lys Asn Leu Phe Ala Val Gly Glu Phe Trp Ser Tyr Asp Val Asn 
            260                 265                 270         


Lys Leu His Asn Tyr Ile Thr Lys Thr Asn Gly Thr Met Ser Leu Phe 
        275                 280                 285             


Asp Ala Pro Leu His Asn Asn Phe Tyr Ile Ala Ser Lys Ser Ser Gly 
    290                 295                 300                 


Tyr Phe Asp Met Arg Tyr Leu Leu Asn Asn Thr Leu Met Lys Asp Gln 
305                 310                 315                 320 


Pro Ala Leu Ala Val Thr Leu Val Asp Asn His Asp Thr Gln Pro Gly 
                325                 330                 335     


Gln Ser Leu Gln Ser Trp Val Glu Pro Trp Phe Lys Pro Leu Ala Tyr 
            340                 345                 350         


Ala Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr Gly 
        355                 360                 365             


Asp Tyr Tyr Gly Ile Pro Lys Tyr Asn Ile Pro Gly Leu Lys Ser Lys 
    370                 375                 380                 


Ile Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr Gln 
385                 390                 395                 400 


Arg Asp Tyr Ile Asp His Pro Asp Ile Ile Gly Trp Thr Arg Glu Gly 
                405                 410                 415     


Ile Asp Ala Lys Pro Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly 
            420                 425                 430         


Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Lys His Ala Gly Lys 
        435                 440                 445             


Val Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile Asn 
    450                 455                 460                 


Ala Asp Gly Trp Gly Gln Phe Lys Val Asn Gly Gly Ser Val Ser Ile 
465                 470                 475                 480 


Trp Val Ala Lys 
                


<210>  73
<211>  482
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  73

Asn Thr Ala Pro Val Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Asp 
1               5                   10                  15      


Leu Pro Asn Asp Gly Thr Leu Trp Thr Lys Val Lys Asn Glu Ala Ala 
            20                  25                  30          


Asn Leu Ser Ser Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Gln Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Ile Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Thr Gln Tyr Ile Gln Ala Ile Gln Ala Ala Lys Ala Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Lys Gly Gly Ala Asp 
            100                 105                 110         


Ala Thr Glu Asp Val Thr Ala Val Glu Val Asp Pro Ala Asp Arg Asn 
        115                 120                 125             


Arg Val Ile Ser Gly Glu His Leu Ile Lys Ala Trp Thr His Phe His 
    130                 135                 140                 


Phe Pro Gly Arg Gly Ser Thr Tyr Ser Asp Phe Lys Trp His Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Glu Ser Arg Lys Leu Asn Arg Ile 
                165                 170                 175     


Tyr Lys Phe Gln Gly Lys Ala Trp Asp Trp Glu Val Ser Asn Glu Phe 
            180                 185                 190         


Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Ile Asp Met Asp His Pro 
        195                 200                 205             


Glu Val Val Ala Glu Leu Lys Asn Trp Gly Lys Trp Tyr Val Asn Thr 
    210                 215                 220                 


Thr Asn Val Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile Lys Tyr 
225                 230                 235                 240 


Ser Phe Phe Pro Asp Trp Leu Ser Tyr Val Arg Asn Gln Thr Gly Lys 
                245                 250                 255     


Asn Leu Phe Ala Val Gly Glu Phe Trp Ser Tyr Asp Val Asn Lys Leu 
            260                 265                 270         


His Asn Tyr Ile Thr Lys Thr Asn Gly Thr Met Ser Leu Phe Asp Ala 
        275                 280                 285             


Pro Leu His Asn Asn Phe Tyr Ile Ala Ser Lys Ser Ser Gly Tyr Phe 
    290                 295                 300                 


Asp Met Arg Tyr Leu Leu Asn Asn Thr Leu Met Lys Asp Gln Pro Ala 
305                 310                 315                 320 


Leu Ala Val Thr Leu Val Asp Asn His Asp Thr Gln Pro Gly Gln Ser 
                325                 330                 335     


Leu Gln Ser Trp Val Glu Pro Trp Phe Lys Pro Leu Ala Tyr Ala Phe 
            340                 345                 350         


Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr Gly Asp Tyr 
        355                 360                 365             


Tyr Gly Ile Pro Lys Tyr Asn Ile Pro Gly Leu Lys Ser Lys Ile Asp 
    370                 375                 380                 


Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr Gln Arg Asp 
385                 390                 395                 400 


Tyr Ile Asp His Pro Asp Ile Ile Gly Trp Thr Arg Glu Gly Ile Asp 
                405                 410                 415     


Ala Lys Pro Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly Pro Gly 
            420                 425                 430         


Gly Ser Lys Trp Met Tyr Val Gly Lys Lys His Ala Gly Lys Val Phe 
        435                 440                 445             


Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile Asn Ala Asp 
    450                 455                 460                 


Gly Trp Gly Gln Phe Lys Val Asn Gly Gly Ser Val Ser Ile Trp Val 
465                 470                 475                 480 


Ala Lys 
        


<210>  74
<211>  484
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  74

Asn Thr Ala Pro Val Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Asp 
1               5                   10                  15      


Leu Pro Asn Asp Gly Thr Leu Trp Thr Lys Val Lys Asn Glu Ala Ala 
            20                  25                  30          


Asn Leu Ser Ser Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Gln Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Ile Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Thr Gln Tyr Ile Gln Ala Ile Gln Ala Ala Lys Ala Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Lys Ala Gly Ala Asp 
            100                 105                 110         


Tyr Thr Glu Asn Val Thr Ala Val Glu Val Asn Pro Ser Asn Arg Asn 
        115                 120                 125             


Gln Glu Thr Ser Gly Glu Tyr Asn Ile Gln Ala Trp Thr Gly Phe Asn 
    130                 135                 140                 


Phe Pro Gly Arg Gly Thr Thr Tyr Ser Asn Phe Lys Trp Gln Trp Phe 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Gln Ser Arg Ser Leu Ser Arg Ile 
                165                 170                 175     


Phe Lys Phe Arg Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Ser Ser 
            180                 185                 190         


Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Ile Asp Met Asp 
        195                 200                 205             


His Pro Glu Val Val Ala Glu Leu Lys Asn Trp Gly Lys Trp Tyr Val 
    210                 215                 220                 


Asn Thr Thr Asn Val Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile 
225                 230                 235                 240 


Lys Tyr Ser Phe Phe Pro Asp Trp Leu Ser Tyr Val Arg Asn Gln Thr 
                245                 250                 255     


Gly Lys Asn Leu Phe Ala Val Gly Glu Phe Trp Ser Tyr Asp Val Asn 
            260                 265                 270         


Lys Leu His Asn Tyr Ile Thr Lys Thr Asn Gly Thr Met Ser Leu Phe 
        275                 280                 285             


Asp Ala Pro Leu His Asn Asn Phe Tyr Ile Ala Ser Lys Ser Ser Gly 
    290                 295                 300                 


Tyr Phe Asp Met Arg Tyr Leu Leu Asn Asn Thr Leu Met Lys Asp Gln 
305                 310                 315                 320 


Pro Ala Leu Ala Val Thr Leu Val Asp Asn His Asp Thr Gln Pro Gly 
                325                 330                 335     


Gln Ser Leu Gln Ser Trp Val Glu Pro Trp Phe Lys Pro Leu Ala Tyr 
            340                 345                 350         


Ala Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr Gly 
        355                 360                 365             


Asp Tyr Tyr Gly Ile Pro Lys Tyr Asn Ile Pro Gly Leu Lys Ser Lys 
    370                 375                 380                 


Ile Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr Gln 
385                 390                 395                 400 


Arg Asp Tyr Ile Asp His Pro Asp Ile Ile Gly Trp Thr Arg Glu Gly 
                405                 410                 415     


Ile Asp Ala Lys Pro Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly 
            420                 425                 430         


Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Lys His Ala Gly Lys 
        435                 440                 445             


Val Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile Asn 
    450                 455                 460                 


Ala Asp Gly Trp Gly Gln Phe Lys Val Asn Gly Gly Ser Val Ser Ile 
465                 470                 475                 480 


Trp Val Ala Lys 
                


<210>  75
<211>  484
<212>  PRT
<213>  Artifiical Sequence

<400>  75

Asn Thr Ala Pro Val Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Asp 
1               5                   10                  15      


Leu Pro Asn Asp Gly Thr Leu Trp Thr Lys Val Lys Asn Glu Ala Ala 
            20                  25                  30          


Asn Leu Ser Ser Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Gln Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Ile Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Thr Gln Tyr Ile Gln Ala Ile Gln Ala Ala Lys Ala Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asp His Lys Gly Gly Ala Asp 
            100                 105                 110         


Gly Thr Glu Trp Val Asp Ala Val Glu Val Asn Pro Ser Asp Arg Asn 
        115                 120                 125             


Gln Glu Ile Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Val Asp Trp Asp Glu Ser Arg Lys Leu Ser Arg Ile 
                165                 170                 175     


Tyr Lys Phe Arg Gly Ile Gly Lys Ala Trp Asp Trp Glu Val Asp Thr 
            180                 185                 190         


Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Leu Asp Met Asp 
        195                 200                 205             


His Pro Glu Val Val Ala Glu Leu Lys Asn Trp Gly Lys Trp Tyr Val 
    210                 215                 220                 


Asn Thr Thr Asn Val Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile 
225                 230                 235                 240 


Lys Tyr Ser Phe Phe Pro Asp Trp Leu Ser Tyr Val Arg Asn Gln Thr 
                245                 250                 255     


Gly Lys Asn Leu Phe Ala Val Gly Glu Phe Trp Ser Tyr Asp Val Asn 
            260                 265                 270         


Lys Leu His Asn Tyr Ile Thr Lys Thr Asn Gly Thr Met Ser Leu Phe 
        275                 280                 285             


Asp Ala Pro Leu His Asn Asn Phe Tyr Ile Ala Ser Lys Ser Ser Gly 
    290                 295                 300                 


Tyr Phe Asp Met Arg Tyr Leu Leu Asn Asn Thr Leu Met Lys Asp Gln 
305                 310                 315                 320 


Pro Ala Leu Ala Val Thr Leu Val Asp Asn His Asp Thr Gln Pro Gly 
                325                 330                 335     


Gln Ser Leu Gln Ser Trp Val Glu Pro Trp Phe Lys Pro Leu Ala Tyr 
            340                 345                 350         


Ala Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr Gly 
        355                 360                 365             


Asp Tyr Tyr Gly Ile Pro Lys Tyr Asn Ile Pro Gly Leu Lys Ser Lys 
    370                 375                 380                 


Ile Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr Gln 
385                 390                 395                 400 


Arg Asp Tyr Ile Asp His Pro Asp Ile Ile Gly Trp Thr Arg Glu Gly 
                405                 410                 415     


Ile Asp Ala Lys Pro Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly 
            420                 425                 430         


Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Lys His Ala Gly Lys 
        435                 440                 445             


Val Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile Asn 
    450                 455                 460                 


Ala Asp Gly Trp Gly Gln Phe Lys Val Asn Gly Gly Ser Val Ser Ile 
465                 470                 475                 480 


Trp Val Ala Lys 
                


<210>  76
<211>  484
<212>  PRT
<213>  Artifiical Sequence

<400>  76

Asn Thr Ala Pro Val Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Asp 
1               5                   10                  15      


Leu Pro Asn Asp Gly Thr Leu Trp Thr Lys Val Lys Asn Glu Ala Ala 
            20                  25                  30          


Asn Leu Ser Ser Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Gln Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Ile Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Thr Gln Tyr Ile Gln Ala Ile Gln Ala Ala Lys Ala Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Lys Ala Gly Ala Asp 
            100                 105                 110         


Gly Thr Glu Leu Val Asp Ala Val Glu Val Asn Pro Ser Asp Arg Asn 
        115                 120                 125             


Gln Glu Ile Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Glu Ser Arg Lys Leu Asn Arg Ile 
                165                 170                 175     


Tyr Lys Phe Arg Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Asp Thr 
            180                 185                 190         


Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Leu Asp Met Asp 
        195                 200                 205             


His Pro Glu Val Val Ala Glu Leu Lys Asn Trp Gly Lys Trp Tyr Val 
    210                 215                 220                 


Asn Thr Thr Asn Val Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile 
225                 230                 235                 240 


Lys Tyr Ser Phe Phe Pro Asp Trp Leu Ser Tyr Val Arg Asn Gln Thr 
                245                 250                 255     


Gly Lys Asn Leu Phe Ala Val Gly Glu Phe Trp Ser Tyr Asp Val Asn 
            260                 265                 270         


Lys Leu His Asn Tyr Ile Thr Lys Thr Asn Gly Thr Met Ser Leu Phe 
        275                 280                 285             


Asp Ala Pro Leu His Asn Asn Phe Tyr Ile Ala Ser Lys Ser Ser Gly 
    290                 295                 300                 


Tyr Phe Asp Met Arg Tyr Leu Leu Asn Asn Thr Leu Met Lys Asp Gln 
305                 310                 315                 320 


Pro Ala Leu Ala Val Thr Leu Val Asp Asn His Asp Thr Gln Pro Gly 
                325                 330                 335     


Gln Ser Leu Gln Ser Trp Val Glu Pro Trp Phe Lys Pro Leu Ala Tyr 
            340                 345                 350         


Ala Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr Gly 
        355                 360                 365             


Asp Tyr Tyr Gly Ile Pro Lys Tyr Asn Ile Pro Gly Leu Lys Ser Lys 
    370                 375                 380                 


Ile Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr Gln 
385                 390                 395                 400 


Arg Asp Tyr Ile Asp His Pro Asp Ile Ile Gly Trp Thr Arg Glu Gly 
                405                 410                 415     


Ile Asp Ala Lys Pro Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly 
            420                 425                 430         


Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Lys His Ala Gly Lys 
        435                 440                 445             


Val Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile Asn 
    450                 455                 460                 


Ala Asp Gly Trp Gly Gln Phe Lys Val Asn Gly Gly Ser Val Ser Ile 
465                 470                 475                 480 


Trp Val Ala Lys 
                


<210>  77
<211>  484
<212>  PRT
<213>  Artifiical Sequence

<400>  77

Asn Thr Ala Pro Val Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Asp 
1               5                   10                  15      


Leu Pro Asn Asp Gly Thr Leu Trp Thr Lys Val Lys Asn Glu Ala Ala 
            20                  25                  30          


Asn Leu Ser Ser Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Gln Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Ile Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Thr Gln Tyr Ile Gln Ala Ile Gln Ala Ala Lys Ala Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Lys Ala Gly Ala Asp 
            100                 105                 110         


Gly Thr Glu Phe Val Asp Ala Val Glu Val Asn Pro Ser Asn Arg Asn 
        115                 120                 125             


Gln Glu Thr Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Glu Ser Arg Lys Leu Asn Arg Val 
                165                 170                 175     


Tyr Lys Phe Arg Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Asp Thr 
            180                 185                 190         


Glu Asn Gly Asn Tyr Asp Tyr Leu Met Phe Ala Asp Leu Asp Met Asp 
        195                 200                 205             


His Pro Glu Val Val Ala Glu Leu Lys Asn Trp Gly Lys Trp Tyr Val 
    210                 215                 220                 


Asn Thr Thr Asn Val Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile 
225                 230                 235                 240 


Lys Tyr Ser Phe Phe Pro Asp Trp Leu Ser Tyr Val Arg Asn Gln Thr 
                245                 250                 255     


Gly Lys Asn Leu Phe Ala Val Gly Glu Phe Trp Ser Tyr Asp Val Asn 
            260                 265                 270         


Lys Leu His Asn Tyr Ile Thr Lys Thr Asn Gly Thr Met Ser Leu Phe 
        275                 280                 285             


Asp Ala Pro Leu His Asn Asn Phe Tyr Ile Ala Ser Lys Ser Ser Gly 
    290                 295                 300                 


Tyr Phe Asp Met Arg Tyr Leu Leu Asn Asn Thr Leu Met Lys Asp Gln 
305                 310                 315                 320 


Pro Ala Leu Ala Val Thr Leu Val Asp Asn His Asp Thr Gln Pro Gly 
                325                 330                 335     


Gln Ser Leu Gln Ser Trp Val Glu Pro Trp Phe Lys Pro Leu Ala Tyr 
            340                 345                 350         


Ala Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr Gly 
        355                 360                 365             


Asp Tyr Tyr Gly Ile Pro Lys Tyr Asn Ile Pro Gly Leu Lys Ser Lys 
    370                 375                 380                 


Ile Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr Gln 
385                 390                 395                 400 


Arg Asp Tyr Ile Asp His Pro Asp Ile Ile Gly Trp Thr Arg Glu Gly 
                405                 410                 415     


Ile Asp Ala Lys Pro Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly 
            420                 425                 430         


Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Lys His Ala Gly Lys 
        435                 440                 445             


Val Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile Asn 
    450                 455                 460                 


Ala Asp Gly Trp Gly Gln Phe Lys Val Asn Gly Gly Ser Val Ser Ile 
465                 470                 475                 480 


Trp Val Ala Lys 
                


<210>  78
<211>  483
<212>  PRT
<213>  Artifiical Sequence

<400>  78

Asn Thr Ala Pro Val Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Asp 
1               5                   10                  15      


Leu Pro Asn Asp Gly Thr Leu Trp Thr Lys Val Lys Asn Glu Ala Ala 
            20                  25                  30          


Asn Leu Ser Ser Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Gln Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Ile Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Thr Gln Tyr Ile Gln Ala Ile Gln Ala Ala Lys Ala Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Lys Ala Gly Ala Asp 
            100                 105                 110         


Gly Thr Glu Phe Val Asp Ala Val Glu Val Asp Pro Ser Asn Arg Asn 
        115                 120                 125             


Gln Glu Thr Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Glu Ser Arg Lys Leu Asn Arg Ile 
                165                 170                 175     


Tyr Lys Phe Ser Thr Gly Lys Ala Trp Asp Trp Glu Val Asp Thr Glu 
            180                 185                 190         


Asn Gly Asn Tyr Asp Tyr Leu Met Phe Ala Asp Leu Asp Met Asp His 
        195                 200                 205             


Pro Glu Val Val Ala Glu Leu Lys Asn Trp Gly Lys Trp Tyr Val Asn 
    210                 215                 220                 


Thr Thr Asn Val Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile Lys 
225                 230                 235                 240 


Tyr Ser Phe Phe Pro Asp Trp Leu Ser Tyr Val Arg Asn Gln Thr Gly 
                245                 250                 255     


Lys Asn Leu Phe Ala Val Gly Glu Phe Trp Ser Tyr Asp Val Asn Lys 
            260                 265                 270         


Leu His Asn Tyr Ile Thr Lys Thr Asn Gly Thr Met Ser Leu Phe Asp 
        275                 280                 285             


Ala Pro Leu His Asn Asn Phe Tyr Ile Ala Ser Lys Ser Ser Gly Tyr 
    290                 295                 300                 


Phe Asp Met Arg Tyr Leu Leu Asn Asn Thr Leu Met Lys Asp Gln Pro 
305                 310                 315                 320 


Ala Leu Ala Val Thr Leu Val Asp Asn His Asp Thr Gln Pro Gly Gln 
                325                 330                 335     


Ser Leu Gln Ser Trp Val Glu Pro Trp Phe Lys Pro Leu Ala Tyr Ala 
            340                 345                 350         


Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr Gly Asp 
        355                 360                 365             


Tyr Tyr Gly Ile Pro Lys Tyr Asn Ile Pro Gly Leu Lys Ser Lys Ile 
    370                 375                 380                 


Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr Gln Arg 
385                 390                 395                 400 


Asp Tyr Ile Asp His Pro Asp Ile Ile Gly Trp Thr Arg Glu Gly Ile 
                405                 410                 415     


Asp Ala Lys Pro Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly Pro 
            420                 425                 430         


Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Lys His Ala Gly Lys Val 
        435                 440                 445             


Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile Asn Ala 
    450                 455                 460                 


Asp Gly Trp Gly Gln Phe Lys Val Asn Gly Gly Ser Val Ser Ile Trp 
465                 470                 475                 480 


Val Ala Lys 
            


<210>  79
<211>  484
<212>  PRT
<213>  Artifiical Sequence

<400>  79

Asn Thr Ala Pro Val Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Asp 
1               5                   10                  15      


Leu Pro Asn Asp Gly Thr Leu Trp Thr Lys Val Lys Asn Glu Ala Ala 
            20                  25                  30          


Asn Leu Ser Ser Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Gln Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Ile Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Thr Gln Tyr Ile Gln Ala Ile Gln Ala Ala Lys Ala Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Lys Ala Gly Ala Asp 
            100                 105                 110         


Gly Thr Glu Phe Val Asp Ala Val Glu Val Asn Pro Ser Asn Arg Asn 
        115                 120                 125             


Gln Glu Thr Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Glu Ser Arg Lys Leu Asn Arg Ile 
                165                 170                 175     


Tyr Lys Phe Arg Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Asp Thr 
            180                 185                 190         


Glu Asn Gly Asn Tyr Asp Tyr Leu Met Phe Ala Asp Leu Asp Met Asp 
        195                 200                 205             


His Pro Glu Val Val Ala Glu Leu Lys Asn Trp Gly Lys Trp Tyr Val 
    210                 215                 220                 


Asn Thr Thr Asn Val Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile 
225                 230                 235                 240 


Lys Tyr Ser Phe Phe Pro Asp Trp Leu Ser Tyr Val Arg Asn Gln Thr 
                245                 250                 255     


Gly Lys Asn Leu Phe Ala Val Gly Glu Phe Trp Ser Tyr Asp Val Asn 
            260                 265                 270         


Lys Leu His Asn Tyr Ile Thr Lys Thr Asn Gly Thr Met Ser Leu Phe 
        275                 280                 285             


Asp Ala Pro Leu His Asn Asn Phe Tyr Ile Ala Ser Lys Ser Ser Gly 
    290                 295                 300                 


Tyr Phe Asp Met Arg Tyr Leu Leu Asn Asn Thr Leu Met Lys Asp Gln 
305                 310                 315                 320 


Pro Ala Leu Ala Val Thr Leu Val Asp Asn His Asp Thr Gln Pro Gly 
                325                 330                 335     


Gln Ser Leu Gln Ser Trp Val Glu Pro Trp Phe Lys Pro Leu Ala Tyr 
            340                 345                 350         


Ala Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr Gly 
        355                 360                 365             


Asp Tyr Tyr Gly Ile Pro Lys Tyr Asn Ile Pro Gly Leu Lys Ser Lys 
    370                 375                 380                 


Ile Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr Gln 
385                 390                 395                 400 


Arg Asp Tyr Ile Asp His Pro Asp Ile Ile Gly Trp Thr Arg Glu Gly 
                405                 410                 415     


Ile Asp Ala Lys Pro Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly 
            420                 425                 430         


Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Lys His Ala Gly Lys 
        435                 440                 445             


Val Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile Asn 
    450                 455                 460                 


Ala Asp Gly Trp Gly Gln Phe Lys Val Asn Gly Gly Ser Val Ser Ile 
465                 470                 475                 480 


Trp Val Ala Lys 
                


<210>  80
<211>  484
<212>  PRT
<213>  Artifiical Sequence

<400>  80

Asn Thr Ala Pro Val Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Asp 
1               5                   10                  15      


Leu Pro Asn Asp Gly Thr Leu Trp Thr Lys Val Lys Asn Glu Ala Ala 
            20                  25                  30          


Asn Leu Ser Ser Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Gln Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Ile Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Thr Gln Tyr Ile Gln Ala Ile Gln Ala Ala Lys Ala Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Lys Ala Gly Ala Asp 
            100                 105                 110         


Ser Thr Glu Trp Val Asp Ala Val Glu Val Asn Pro Ser Asn Arg Asn 
        115                 120                 125             


Gln Glu Thr Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Glu Ser Arg Lys Leu Asn Arg Ile 
                165                 170                 175     


Tyr Lys Phe Arg Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Asp Thr 
            180                 185                 190         


Glu Asn Gly Asn Tyr Asp Tyr Leu Met Phe Ala Asp Leu Asp Met Asp 
        195                 200                 205             


His Pro Glu Val Val Ala Glu Leu Lys Asn Trp Gly Lys Trp Tyr Val 
    210                 215                 220                 


Asn Thr Thr Asn Val Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile 
225                 230                 235                 240 


Lys Tyr Ser Phe Phe Pro Asp Trp Leu Ser Tyr Val Arg Asn Gln Thr 
                245                 250                 255     


Gly Lys Asn Leu Phe Ala Val Gly Glu Phe Trp Ser Tyr Asp Val Asn 
            260                 265                 270         


Lys Leu His Asn Tyr Ile Thr Lys Thr Asn Gly Thr Met Ser Leu Phe 
        275                 280                 285             


Asp Ala Pro Leu His Asn Asn Phe Tyr Ile Ala Ser Lys Ser Ser Gly 
    290                 295                 300                 


Tyr Phe Asp Met Arg Tyr Leu Leu Asn Asn Thr Leu Met Lys Asp Gln 
305                 310                 315                 320 


Pro Ala Leu Ala Val Thr Leu Val Asp Asn His Asp Thr Gln Pro Gly 
                325                 330                 335     


Gln Ser Leu Gln Ser Trp Val Glu Pro Trp Phe Lys Pro Leu Ala Tyr 
            340                 345                 350         


Ala Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr Gly 
        355                 360                 365             


Asp Tyr Tyr Gly Ile Pro Lys Tyr Asn Ile Pro Gly Leu Lys Ser Lys 
    370                 375                 380                 


Ile Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr Gln 
385                 390                 395                 400 


Arg Asp Tyr Ile Asp His Pro Asp Ile Ile Gly Trp Thr Arg Glu Gly 
                405                 410                 415     


Ile Asp Ala Lys Pro Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly 
            420                 425                 430         


Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Lys His Ala Gly Lys 
        435                 440                 445             


Val Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile Asn 
    450                 455                 460                 


Ala Asp Gly Trp Gly Gln Phe Lys Val Asn Gly Gly Ser Val Ser Ile 
465                 470                 475                 480 


Trp Val Ala Lys 
                


<210>  81
<211>  485
<212>  PRT
<213>  Artifiical Sequence

<400>  81

Asn Thr Ala Pro Val Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Asp 
1               5                   10                  15      


Leu Pro Asn Asp Gly Thr Leu Trp Thr Lys Val Lys Asn Glu Ala Ala 
            20                  25                  30          


Asn Leu Ser Ser Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Gln Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Ile Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Thr Gln Tyr Ile Gln Ala Ile Gln Ala Ala Lys Ala Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Lys Gly Gly Ala Asp 
            100                 105                 110         


Phe Thr Glu Arg Val Gln Ala Val Glu Val Asn Pro Gln Asn Arg Asn 
        115                 120                 125             


Gln Glu Val Ser Gly Thr Tyr Gln Ile Glu Ala Trp Thr Gly Phe Asn 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Gln His Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Gln Ser Arg Gln Leu Ala Asn Arg 
                165                 170                 175     


Ile Tyr Lys Phe Arg Gly Asp Gly Lys Ala Trp Asp Trp Glu Val Asp 
            180                 185                 190         


Thr Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Val Asp Met 
        195                 200                 205             


Asp His Pro Glu Val Val Ala Glu Leu Lys Asn Trp Gly Lys Trp Tyr 
    210                 215                 220                 


Val Asn Thr Thr Asn Val Asp Gly Phe Arg Leu Asp Ala Val Lys His 
225                 230                 235                 240 


Ile Lys Tyr Ser Phe Phe Pro Asp Trp Leu Ser Tyr Val Arg Asn Gln 
                245                 250                 255     


Thr Gly Lys Asn Leu Phe Ala Val Gly Glu Phe Trp Ser Tyr Asp Val 
            260                 265                 270         


Asn Lys Leu His Asn Tyr Ile Thr Lys Thr Asn Gly Thr Met Ser Leu 
        275                 280                 285             


Phe Asp Ala Pro Leu His Asn Asn Phe Tyr Ile Ala Ser Lys Ser Ser 
    290                 295                 300                 


Gly Tyr Phe Asp Met Arg Tyr Leu Leu Asn Asn Thr Leu Met Lys Asp 
305                 310                 315                 320 


Gln Pro Ala Leu Ala Val Thr Leu Val Asp Asn His Asp Thr Gln Pro 
                325                 330                 335     


Gly Gln Ser Leu Gln Ser Trp Val Glu Pro Trp Phe Lys Pro Leu Ala 
            340                 345                 350         


Tyr Ala Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr 
        355                 360                 365             


Gly Asp Tyr Tyr Gly Ile Pro Lys Tyr Asn Ile Pro Gly Leu Lys Ser 
    370                 375                 380                 


Lys Ile Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr 
385                 390                 395                 400 


Gln Arg Asp Tyr Ile Asp His Pro Asp Ile Ile Gly Trp Thr Arg Glu 
                405                 410                 415     


Gly Ile Asp Ala Lys Pro Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp 
            420                 425                 430         


Gly Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Lys His Ala Gly 
        435                 440                 445             


Lys Val Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile 
    450                 455                 460                 


Asn Ala Asp Gly Trp Gly Gln Phe Lys Val Asn Gly Gly Ser Val Ser 
465                 470                 475                 480 


Ile Trp Val Ala Lys 
                485 


<210>  82
<211>  485
<212>  PRT
<213>  Artifiical Sequence

<400>  82

Asn Thr Ala Pro Val Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Asp 
1               5                   10                  15      


Leu Pro Asn Asp Gly Thr Leu Trp Thr Lys Val Lys Asn Glu Ala Ala 
            20                  25                  30          


Asn Leu Ser Ser Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Gln Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Ile Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Thr Gln Tyr Ile Gln Ala Ile Gln Ala Ala Lys Ala Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Lys Gly Gly Ala Asp 
            100                 105                 110         


Ala Thr Glu Asn Val Leu Ala Val Glu Val Asn Pro Asn Asn Arg Asn 
        115                 120                 125             


Gln Glu Ile Ser Gly Asp Tyr Thr Ile Glu Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Asp Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Val Asp Trp Asp Gln Ser Arg Gln Phe Gln Asn Arg 
                165                 170                 175     


Ile Tyr Lys Phe Arg Gly Asp Gly Lys Ala Trp Asp Trp Glu Val Asp 
            180                 185                 190         


Ser Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Val Asp Met 
        195                 200                 205             


Asp His Pro Glu Val Val Ala Glu Leu Lys Asn Trp Gly Lys Trp Tyr 
    210                 215                 220                 


Val Asn Thr Thr Asn Val Asp Gly Phe Arg Leu Asp Ala Val Lys His 
225                 230                 235                 240 


Ile Lys Tyr Ser Phe Phe Pro Asp Trp Leu Ser Tyr Val Arg Asn Gln 
                245                 250                 255     


Thr Gly Lys Asn Leu Phe Ala Val Gly Glu Phe Trp Ser Tyr Asp Val 
            260                 265                 270         


Asn Lys Leu His Asn Tyr Ile Thr Lys Thr Asn Gly Thr Met Ser Leu 
        275                 280                 285             


Phe Asp Ala Pro Leu His Asn Asn Phe Tyr Ile Ala Ser Lys Ser Ser 
    290                 295                 300                 


Gly Tyr Phe Asp Met Arg Tyr Leu Leu Asn Asn Thr Leu Met Lys Asp 
305                 310                 315                 320 


Gln Pro Ala Leu Ala Val Thr Leu Val Asp Asn His Asp Thr Gln Pro 
                325                 330                 335     


Gly Gln Ser Leu Gln Ser Trp Val Glu Pro Trp Phe Lys Pro Leu Ala 
            340                 345                 350         


Tyr Ala Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr 
        355                 360                 365             


Gly Asp Tyr Tyr Gly Ile Pro Lys Tyr Asn Ile Pro Gly Leu Lys Ser 
    370                 375                 380                 


Lys Ile Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr 
385                 390                 395                 400 


Gln Arg Asp Tyr Ile Asp His Pro Asp Ile Ile Gly Trp Thr Arg Glu 
                405                 410                 415     


Gly Ile Asp Ala Lys Pro Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp 
            420                 425                 430         


Gly Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Lys His Ala Gly 
        435                 440                 445             


Lys Val Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile 
    450                 455                 460                 


Asn Ala Asp Gly Trp Gly Gln Phe Lys Val Asn Gly Gly Ser Val Ser 
465                 470                 475                 480 


Ile Trp Val Ala Lys 
                485 


<210>  83
<211>  485
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  83

Asn Thr Ala Pro Val Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Asp 
1               5                   10                  15      


Leu Pro Asn Asp Gly Thr Leu Trp Thr Lys Val Lys Asn Glu Ala Ala 
            20                  25                  30          


Asn Leu Ser Ser Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Gln Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Ile Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Thr Gln Tyr Ile Gln Ala Ile Gln Ala Ala Lys Ala Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Lys Gly Gly Ala Asp 
            100                 105                 110         


Ala Thr Glu Met Val Arg Ala Val Glu Val Asn Pro Asn Asn Arg Asn 
        115                 120                 125             


Gln Glu Val Ser Gly Glu Tyr Thr Ile Glu Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr His Ser Asn Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Val Asp Trp Asp Gln Ser Arg Lys Leu Asn Asn Arg 
                165                 170                 175     


Ile Tyr Lys Phe Arg Gly Asp Gly Lys Gly Trp Asp Trp Glu Val Asp 
            180                 185                 190         


Thr Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Ile Asp Met 
        195                 200                 205             


Asp His Pro Glu Val Val Ala Glu Leu Lys Asn Trp Gly Lys Trp Tyr 
    210                 215                 220                 


Val Asn Thr Thr Asn Val Asp Gly Phe Arg Leu Asp Ala Val Lys His 
225                 230                 235                 240 


Ile Lys Tyr Ser Phe Phe Pro Asp Trp Leu Ser Tyr Val Arg Asn Gln 
                245                 250                 255     


Thr Gly Lys Asn Leu Phe Ala Val Gly Glu Phe Trp Ser Tyr Asp Val 
            260                 265                 270         


Asn Lys Leu His Asn Tyr Ile Thr Lys Thr Asn Gly Thr Met Ser Leu 
        275                 280                 285             


Phe Asp Ala Pro Leu His Asn Asn Phe Tyr Ile Ala Ser Lys Ser Ser 
    290                 295                 300                 


Gly Tyr Phe Asp Met Arg Tyr Leu Leu Asn Asn Thr Leu Met Lys Asp 
305                 310                 315                 320 


Gln Pro Ala Leu Ala Val Thr Leu Val Asp Asn His Asp Thr Gln Pro 
                325                 330                 335     


Gly Gln Ser Leu Gln Ser Trp Val Glu Pro Trp Phe Lys Pro Leu Ala 
            340                 345                 350         


Tyr Ala Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr 
        355                 360                 365             


Gly Asp Tyr Tyr Gly Ile Pro Lys Tyr Asn Ile Pro Gly Leu Lys Ser 
    370                 375                 380                 


Lys Ile Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr 
385                 390                 395                 400 


Gln Arg Asp Tyr Ile Asp His Pro Asp Ile Ile Gly Trp Thr Arg Glu 
                405                 410                 415     


Gly Ile Asp Ala Lys Pro Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp 
            420                 425                 430         


Gly Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Lys His Ala Gly 
        435                 440                 445             


Lys Val Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile 
    450                 455                 460                 


Asn Ala Asp Gly Trp Gly Gln Phe Lys Val Asn Gly Gly Ser Val Ser 
465                 470                 475                 480 


Ile Trp Val Ala Lys 
                485 


<210>  84
<211>  485
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  84

Asn Thr Ala Pro Val Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Asp 
1               5                   10                  15      


Leu Pro Asn Asp Gly Thr Leu Trp Thr Lys Val Lys Asn Glu Ala Ala 
            20                  25                  30          


Asn Leu Ser Ser Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Gln Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Ile Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Thr Gln Tyr Ile Gln Ala Ile Gln Ala Ala Lys Ala Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Lys Gly Gly Ala Asp 
            100                 105                 110         


Ala Thr Glu Met Val Arg Ala Val Glu Val Asn Pro Asn Asn Arg Asn 
        115                 120                 125             


Gln Glu Val Thr Gly Glu Tyr Thr Ile Glu Ala Trp Thr Arg Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr His Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Val Asp Trp Asp Gln Ser Arg Arg Leu Asn Asn Arg 
                165                 170                 175     


Ile Tyr Lys Phe Arg Gly His Gly Lys Ala Trp Asp Trp Glu Val Asp 
            180                 185                 190         


Thr Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Ile Asp Met 
        195                 200                 205             


Asp His Pro Glu Val Val Ala Glu Leu Lys Asn Trp Gly Lys Trp Tyr 
    210                 215                 220                 


Val Asn Thr Thr Asn Val Asp Gly Phe Arg Leu Asp Ala Val Lys His 
225                 230                 235                 240 


Ile Lys Tyr Ser Phe Phe Pro Asp Trp Leu Ser Tyr Val Arg Asn Gln 
                245                 250                 255     


Thr Gly Lys Asn Leu Phe Ala Val Gly Glu Phe Trp Ser Tyr Asp Val 
            260                 265                 270         


Asn Lys Leu His Asn Tyr Ile Thr Lys Thr Asn Gly Thr Met Ser Leu 
        275                 280                 285             


Phe Asp Ala Pro Leu His Asn Asn Phe Tyr Ile Ala Ser Lys Ser Ser 
    290                 295                 300                 


Gly Tyr Phe Asp Met Arg Tyr Leu Leu Asn Asn Thr Leu Met Lys Asp 
305                 310                 315                 320 


Gln Pro Ala Leu Ala Val Thr Leu Val Asp Asn His Asp Thr Gln Pro 
                325                 330                 335     


Gly Gln Ser Leu Gln Ser Trp Val Glu Pro Trp Phe Lys Pro Leu Ala 
            340                 345                 350         


Tyr Ala Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr 
        355                 360                 365             


Gly Asp Tyr Tyr Gly Ile Pro Lys Tyr Asn Ile Pro Gly Leu Lys Ser 
    370                 375                 380                 


Lys Ile Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr 
385                 390                 395                 400 


Gln Arg Asp Tyr Ile Asp His Pro Asp Ile Ile Gly Trp Thr Arg Glu 
                405                 410                 415     


Gly Ile Asp Ala Lys Pro Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp 
            420                 425                 430         


Gly Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Lys His Ala Gly 
        435                 440                 445             


Lys Val Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile 
    450                 455                 460                 


Asn Ala Asp Gly Trp Gly Gln Phe Lys Val Asn Gly Gly Ser Val Ser 
465                 470                 475                 480 


Ile Trp Val Ala Lys 
                485 


<210>  85
<211>  485
<212>  PRT
<213>  Artifiical Sequence

<400>  85

Asn Thr Ala Pro Val Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Asp 
1               5                   10                  15      


Leu Pro Asn Asp Gly Thr Leu Trp Thr Lys Val Lys Asn Glu Ala Ser 
            20                  25                  30          


Ser Leu Ser Ala Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Gln Ala Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Ile Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Thr Gln Tyr Leu Gln Ala Ile Gln Ala Ala Lys Ser Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Arg Met Gly Ala Asp 
            100                 105                 110         


Ala Thr Glu Thr Ile Ser Ala Val Glu Val Asn Pro Ser Asn Arg Asn 
        115                 120                 125             


Gln Val Thr Ser Gly Ala Tyr Asn Ile Ser Ala Trp Thr Asp Phe Glu 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp His Ser Tyr 
145                 150                 155                 160 


Tyr Phe Asp Gly Val Asp Trp Asp Gln Ser Arg Gln Leu Ser Gly Lys 
                165                 170                 175     


Ile Tyr Gln Ile Gln Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Asp 
            180                 185                 190         


Ser Glu Asn Gly Asn Tyr Asp Tyr Leu Met Gly Ala Asp Ile Asp Met 
        195                 200                 205             


Asp His Pro Glu Val Val Ala Glu Leu Lys Asn Trp Gly Lys Trp Tyr 
    210                 215                 220                 


Val Asn Thr Thr Asn Val Asp Gly Phe Arg Leu Asp Ala Val Lys His 
225                 230                 235                 240 


Ile Lys Tyr Ser Phe Phe Pro Asp Trp Leu Ser Tyr Val Arg Asn Gln 
                245                 250                 255     


Thr Gly Lys Asn Leu Phe Ala Val Gly Glu Phe Trp Gly Tyr Asp Val 
            260                 265                 270         


Asn Lys Leu His Asn Tyr Ile Thr Lys Thr Asn Gly Ala Met Ser Leu 
        275                 280                 285             


Phe Asp Ala Pro Leu His Asn Asn Phe Tyr Ile Ala Ser Lys Ser Ser 
    290                 295                 300                 


Gly Tyr Phe Asp Met Arg Tyr Leu Leu Asn Asn Thr Leu Met Lys Asp 
305                 310                 315                 320 


Gln Pro Ala Leu Ala Val Thr Leu Val Asp Asn His Asp Thr Gln Pro 
                325                 330                 335     


Gly Gln Ser Leu Gln Ser Trp Val Glu Pro Trp Phe Lys Pro Leu Ala 
            340                 345                 350         


Tyr Ala Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr 
        355                 360                 365             


Gly Asp Tyr Tyr Gly Ile Pro Lys Tyr Asn Ile Pro Gly Leu Lys Ser 
    370                 375                 380                 


Lys Ile Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr 
385                 390                 395                 400 


Gln Arg Asp Tyr Ile Asp His Gln Asp Ile Ile Gly Trp Thr Arg Glu 
                405                 410                 415     


Gly Ile Asp Ala Lys Pro Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp 
            420                 425                 430         


Gly Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Arg His Ala Gly 
        435                 440                 445             


Lys Val Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile 
    450                 455                 460                 


Asn Ala Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser 
465                 470                 475                 480 


Ile Trp Val Ala Lys 
                485 


<210>  86
<211>  484
<212>  PRT
<213>  Artifiical Sequence

<400>  86

Asn Thr Ala Pro Val Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Asp 
1               5                   10                  15      


Leu Pro Asn Asp Gly Thr Leu Trp Thr Lys Val Lys Asn Glu Ala Ser 
            20                  25                  30          


Ser Leu Ser Ala Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Gln Ala Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Ile Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Thr Gln Tyr Leu Gln Ala Ile Gln Ala Ala Lys Ser Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Lys Ala Gly Ala Asp 
            100                 105                 110         


Ala Thr Glu Asp Val Thr Ala Val Glu Val Asn Pro Ala Asn Arg Asn 
        115                 120                 125             


Gln Glu Thr Ser Glu Glu Tyr Gln Ile Lys Ala Trp Thr Asp Phe Arg 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Asp Phe Lys Trp His Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Ala Asp Trp Asp Glu Ser Arg Lys Ile Ser Arg Ile 
                165                 170                 175     


Phe Lys Phe Arg Gly Glu Gly Lys Ala Trp Asp Trp Glu Val Ser Ser 
            180                 185                 190         


Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Val Asp Met Asp 
        195                 200                 205             


His Pro Glu Val Val Ala Glu Leu Lys Asn Trp Gly Lys Trp Tyr Val 
    210                 215                 220                 


Asn Thr Thr Asn Val Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile 
225                 230                 235                 240 


Lys Tyr Ser Phe Phe Pro Asp Trp Leu Ser Tyr Val Arg Asn Gln Thr 
                245                 250                 255     


Gly Lys Asn Leu Phe Ala Val Gly Glu Phe Trp Gly Tyr Asp Val Asn 
            260                 265                 270         


Lys Leu His Asn Tyr Ile Thr Lys Thr Asn Gly Ala Met Ser Leu Phe 
        275                 280                 285             


Asp Ala Pro Leu His Asn Asn Phe Tyr Ile Ala Ser Lys Ser Ser Gly 
    290                 295                 300                 


Tyr Phe Asp Met Arg Tyr Leu Leu Asn Asn Thr Leu Met Lys Asp Gln 
305                 310                 315                 320 


Pro Ala Leu Ala Val Thr Leu Val Asp Asn His Asp Thr Gln Pro Gly 
                325                 330                 335     


Gln Ser Leu Gln Ser Trp Val Glu Pro Trp Phe Lys Pro Leu Ala Tyr 
            340                 345                 350         


Ala Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr Gly 
        355                 360                 365             


Asp Tyr Tyr Gly Ile Pro Lys Tyr Asn Ile Pro Gly Leu Lys Ser Lys 
    370                 375                 380                 


Ile Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr Gln 
385                 390                 395                 400 


Arg Asp Tyr Ile Asp His Gln Asp Ile Ile Gly Trp Thr Arg Glu Gly 
                405                 410                 415     


Ile Asp Ala Lys Pro Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly 
            420                 425                 430         


Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Arg His Ala Gly Lys 
        435                 440                 445             


Val Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile Asn 
    450                 455                 460                 


Ala Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser Ile 
465                 470                 475                 480 


Trp Val Ala Lys 
                


<210>  87
<211>  482
<212>  PRT
<213>  Artifiical Sequence

<400>  87

Asn Thr Ala Pro Val Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Asp 
1               5                   10                  15      


Leu Pro Asn Asp Gly Thr Leu Trp Thr Lys Val Lys Asn Glu Ala Ser 
            20                  25                  30          


Ser Leu Ser Ala Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Gln Ala Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Ile Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Thr Gln Tyr Leu Gln Ala Ile Gln Ala Ala Lys Ser Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Lys Gly Gly Ala Asp 
            100                 105                 110         


Ala Thr Glu Asp Val Thr Ala Val Glu Val Asp Pro Ala Asp Arg Asn 
        115                 120                 125             


Arg Val Ile Ser Gly Glu His Leu Ile Lys Ala Trp Thr His Phe His 
    130                 135                 140                 


Phe Pro Gly Arg Gly Ser Thr Tyr Ser Asp Phe Lys Trp His Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Glu Ser Arg Lys Leu Asn Arg Ile 
                165                 170                 175     


Tyr Lys Phe Gln Gly Lys Ala Trp Asp Trp Glu Val Ser Asn Glu Phe 
            180                 185                 190         


Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Ile Asp Met Asp His Pro 
        195                 200                 205             


Glu Val Val Ala Glu Leu Lys Asn Trp Gly Lys Trp Tyr Val Asn Thr 
    210                 215                 220                 


Thr Asn Val Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile Lys Tyr 
225                 230                 235                 240 


Ser Phe Phe Pro Asp Trp Leu Ser Tyr Val Arg Asn Gln Thr Gly Lys 
                245                 250                 255     


Asn Leu Phe Ala Val Gly Glu Phe Trp Gly Tyr Asp Val Asn Lys Leu 
            260                 265                 270         


His Asn Tyr Ile Thr Lys Thr Asn Gly Ala Met Ser Leu Phe Asp Ala 
        275                 280                 285             


Pro Leu His Asn Asn Phe Tyr Ile Ala Ser Lys Ser Ser Gly Tyr Phe 
    290                 295                 300                 


Asp Met Arg Tyr Leu Leu Asn Asn Thr Leu Met Lys Asp Gln Pro Ala 
305                 310                 315                 320 


Leu Ala Val Thr Leu Val Asp Asn His Asp Thr Gln Pro Gly Gln Ser 
                325                 330                 335     


Leu Gln Ser Trp Val Glu Pro Trp Phe Lys Pro Leu Ala Tyr Ala Phe 
            340                 345                 350         


Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr Gly Asp Tyr 
        355                 360                 365             


Tyr Gly Ile Pro Lys Tyr Asn Ile Pro Gly Leu Lys Ser Lys Ile Asp 
    370                 375                 380                 


Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr Gln Arg Asp 
385                 390                 395                 400 


Tyr Ile Asp His Gln Asp Ile Ile Gly Trp Thr Arg Glu Gly Ile Asp 
                405                 410                 415     


Ala Lys Pro Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly Pro Gly 
            420                 425                 430         


Gly Ser Lys Trp Met Tyr Val Gly Lys Arg His Ala Gly Lys Val Phe 
        435                 440                 445             


Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile Asn Ala Asp 
    450                 455                 460                 


Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser Ile Trp Val 
465                 470                 475                 480 


Ala Lys 
        


<210>  88
<211>  484
<212>  PRT
<213>  Artifiical Sequence

<400>  88

Asn Thr Ala Pro Val Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Asp 
1               5                   10                  15      


Leu Pro Asn Asp Gly Thr Leu Trp Thr Lys Val Lys Asn Glu Ala Ser 
            20                  25                  30          


Ser Leu Ser Ala Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Gln Ala Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Ile Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Thr Gln Tyr Leu Gln Ala Ile Gln Ala Ala Lys Ser Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Lys Ala Gly Ala Asp 
            100                 105                 110         


Tyr Thr Glu Asn Val Thr Ala Val Glu Val Asn Pro Ser Asn Arg Asn 
        115                 120                 125             


Gln Glu Thr Ser Gly Glu Tyr Asn Ile Gln Ala Trp Thr Gly Phe Asn 
    130                 135                 140                 


Phe Pro Gly Arg Gly Thr Thr Tyr Ser Asn Phe Lys Trp Gln Trp Phe 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Gln Ser Arg Ser Leu Ser Arg Ile 
                165                 170                 175     


Phe Lys Phe Arg Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Ser Ser 
            180                 185                 190         


Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Ile Asp Met Asp 
        195                 200                 205             


His Pro Glu Val Val Ala Glu Leu Lys Asn Trp Gly Lys Trp Tyr Val 
    210                 215                 220                 


Asn Thr Thr Asn Val Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile 
225                 230                 235                 240 


Lys Tyr Ser Phe Phe Pro Asp Trp Leu Ser Tyr Val Arg Asn Gln Thr 
                245                 250                 255     


Gly Lys Asn Leu Phe Ala Val Gly Glu Phe Trp Gly Tyr Asp Val Asn 
            260                 265                 270         


Lys Leu His Asn Tyr Ile Thr Lys Thr Asn Gly Ala Met Ser Leu Phe 
        275                 280                 285             


Asp Ala Pro Leu His Asn Asn Phe Tyr Ile Ala Ser Lys Ser Ser Gly 
    290                 295                 300                 


Tyr Phe Asp Met Arg Tyr Leu Leu Asn Asn Thr Leu Met Lys Asp Gln 
305                 310                 315                 320 


Pro Ala Leu Ala Val Thr Leu Val Asp Asn His Asp Thr Gln Pro Gly 
                325                 330                 335     


Gln Ser Leu Gln Ser Trp Val Glu Pro Trp Phe Lys Pro Leu Ala Tyr 
            340                 345                 350         


Ala Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr Gly 
        355                 360                 365             


Asp Tyr Tyr Gly Ile Pro Lys Tyr Asn Ile Pro Gly Leu Lys Ser Lys 
    370                 375                 380                 


Ile Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr Gln 
385                 390                 395                 400 


Arg Asp Tyr Ile Asp His Gln Asp Ile Ile Gly Trp Thr Arg Glu Gly 
                405                 410                 415     


Ile Asp Ala Lys Pro Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly 
            420                 425                 430         


Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Arg His Ala Gly Lys 
        435                 440                 445             


Val Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile Asn 
    450                 455                 460                 


Ala Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser Ile 
465                 470                 475                 480 


Trp Val Ala Lys 
                


<210>  89
<211>  484
<212>  PRT
<213>  Artifiical Sequence

<400>  89

Asn Thr Ala Pro Val Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Asp 
1               5                   10                  15      


Leu Pro Asn Asp Gly Thr Leu Trp Thr Lys Val Lys Asn Glu Ala Ser 
            20                  25                  30          


Ser Leu Ser Ala Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Gln Ala Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Ile Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Thr Gln Tyr Leu Gln Ala Ile Gln Ala Ala Lys Ser Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asp His Lys Gly Gly Ala Asp 
            100                 105                 110         


Gly Thr Glu Trp Val Asp Ala Val Glu Val Asn Pro Ser Asp Arg Asn 
        115                 120                 125             


Gln Glu Ile Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Val Asp Trp Asp Glu Ser Arg Lys Leu Ser Arg Ile 
                165                 170                 175     


Tyr Lys Phe Arg Gly Ile Gly Lys Ala Trp Asp Trp Glu Val Asp Thr 
            180                 185                 190         


Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Leu Asp Met Asp 
        195                 200                 205             


His Pro Glu Val Val Ala Glu Leu Lys Asn Trp Gly Lys Trp Tyr Val 
    210                 215                 220                 


Asn Thr Thr Asn Val Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile 
225                 230                 235                 240 


Lys Tyr Ser Phe Phe Pro Asp Trp Leu Ser Tyr Val Arg Asn Gln Thr 
                245                 250                 255     


Gly Lys Asn Leu Phe Ala Val Gly Glu Phe Trp Gly Tyr Asp Val Asn 
            260                 265                 270         


Lys Leu His Asn Tyr Ile Thr Lys Thr Asn Gly Ala Met Ser Leu Phe 
        275                 280                 285             


Asp Ala Pro Leu His Asn Asn Phe Tyr Ile Ala Ser Lys Ser Ser Gly 
    290                 295                 300                 


Tyr Phe Asp Met Arg Tyr Leu Leu Asn Asn Thr Leu Met Lys Asp Gln 
305                 310                 315                 320 


Pro Ala Leu Ala Val Thr Leu Val Asp Asn His Asp Thr Gln Pro Gly 
                325                 330                 335     


Gln Ser Leu Gln Ser Trp Val Glu Pro Trp Phe Lys Pro Leu Ala Tyr 
            340                 345                 350         


Ala Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr Gly 
        355                 360                 365             


Asp Tyr Tyr Gly Ile Pro Lys Tyr Asn Ile Pro Gly Leu Lys Ser Lys 
    370                 375                 380                 


Ile Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr Gln 
385                 390                 395                 400 


Arg Asp Tyr Ile Asp His Gln Asp Ile Ile Gly Trp Thr Arg Glu Gly 
                405                 410                 415     


Ile Asp Ala Lys Pro Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly 
            420                 425                 430         


Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Arg His Ala Gly Lys 
        435                 440                 445             


Val Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile Asn 
    450                 455                 460                 


Ala Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser Ile 
465                 470                 475                 480 


Trp Val Ala Lys 
                


<210>  90
<211>  484
<212>  PRT
<213>  Artifiical Sequence

<400>  90

Asn Thr Ala Pro Val Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Asp 
1               5                   10                  15      


Leu Pro Asn Asp Gly Thr Leu Trp Thr Lys Val Lys Asn Glu Ala Ser 
            20                  25                  30          


Ser Leu Ser Ala Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Gln Ala Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Ile Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Thr Gln Tyr Leu Gln Ala Ile Gln Ala Ala Lys Ser Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Lys Ala Gly Ala Asp 
            100                 105                 110         


Gly Thr Glu Leu Val Asp Ala Val Glu Val Asn Pro Ser Asp Arg Asn 
        115                 120                 125             


Gln Glu Ile Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Glu Ser Arg Lys Leu Asn Arg Ile 
                165                 170                 175     


Tyr Lys Phe Arg Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Asp Thr 
            180                 185                 190         


Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Leu Asp Met Asp 
        195                 200                 205             


His Pro Glu Val Val Ala Glu Leu Lys Asn Trp Gly Lys Trp Tyr Val 
    210                 215                 220                 


Asn Thr Thr Asn Val Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile 
225                 230                 235                 240 


Lys Tyr Ser Phe Phe Pro Asp Trp Leu Ser Tyr Val Arg Asn Gln Thr 
                245                 250                 255     


Gly Lys Asn Leu Phe Ala Val Gly Glu Phe Trp Gly Tyr Asp Val Asn 
            260                 265                 270         


Lys Leu His Asn Tyr Ile Thr Lys Thr Asn Gly Ala Met Ser Leu Phe 
        275                 280                 285             


Asp Ala Pro Leu His Asn Asn Phe Tyr Ile Ala Ser Lys Ser Ser Gly 
    290                 295                 300                 


Tyr Phe Asp Met Arg Tyr Leu Leu Asn Asn Thr Leu Met Lys Asp Gln 
305                 310                 315                 320 


Pro Ala Leu Ala Val Thr Leu Val Asp Asn His Asp Thr Gln Pro Gly 
                325                 330                 335     


Gln Ser Leu Gln Ser Trp Val Glu Pro Trp Phe Lys Pro Leu Ala Tyr 
            340                 345                 350         


Ala Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr Gly 
        355                 360                 365             


Asp Tyr Tyr Gly Ile Pro Lys Tyr Asn Ile Pro Gly Leu Lys Ser Lys 
    370                 375                 380                 


Ile Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr Gln 
385                 390                 395                 400 


Arg Asp Tyr Ile Asp His Gln Asp Ile Ile Gly Trp Thr Arg Glu Gly 
                405                 410                 415     


Ile Asp Ala Lys Pro Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly 
            420                 425                 430         


Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Arg His Ala Gly Lys 
        435                 440                 445             


Val Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile Asn 
    450                 455                 460                 


Ala Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser Ile 
465                 470                 475                 480 


Trp Val Ala Lys 
                


<210>  91
<211>  484
<212>  PRT
<213>  Artifiical Sequence

<400>  91

Asn Thr Ala Pro Val Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Asp 
1               5                   10                  15      


Leu Pro Asn Asp Gly Thr Leu Trp Thr Lys Val Lys Asn Glu Ala Ser 
            20                  25                  30          


Ser Leu Ser Ala Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Gln Ala Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Ile Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Thr Gln Tyr Leu Gln Ala Ile Gln Ala Ala Lys Ser Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Lys Ala Gly Ala Asp 
            100                 105                 110         


Gly Thr Glu Phe Val Asp Ala Val Glu Val Asn Pro Ser Asn Arg Asn 
        115                 120                 125             


Gln Glu Thr Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Glu Ser Arg Lys Leu Asn Arg Val 
                165                 170                 175     


Tyr Lys Phe Arg Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Asp Thr 
            180                 185                 190         


Glu Asn Gly Asn Tyr Asp Tyr Leu Met Phe Ala Asp Leu Asp Met Asp 
        195                 200                 205             


His Pro Glu Val Val Ala Glu Leu Lys Asn Trp Gly Lys Trp Tyr Val 
    210                 215                 220                 


Asn Thr Thr Asn Val Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile 
225                 230                 235                 240 


Lys Tyr Ser Phe Phe Pro Asp Trp Leu Ser Tyr Val Arg Asn Gln Thr 
                245                 250                 255     


Gly Lys Asn Leu Phe Ala Val Gly Glu Phe Trp Gly Tyr Asp Val Asn 
            260                 265                 270         


Lys Leu His Asn Tyr Ile Thr Lys Thr Asn Gly Ala Met Ser Leu Phe 
        275                 280                 285             


Asp Ala Pro Leu His Asn Asn Phe Tyr Ile Ala Ser Lys Ser Ser Gly 
    290                 295                 300                 


Tyr Phe Asp Met Arg Tyr Leu Leu Asn Asn Thr Leu Met Lys Asp Gln 
305                 310                 315                 320 


Pro Ala Leu Ala Val Thr Leu Val Asp Asn His Asp Thr Gln Pro Gly 
                325                 330                 335     


Gln Ser Leu Gln Ser Trp Val Glu Pro Trp Phe Lys Pro Leu Ala Tyr 
            340                 345                 350         


Ala Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr Gly 
        355                 360                 365             


Asp Tyr Tyr Gly Ile Pro Lys Tyr Asn Ile Pro Gly Leu Lys Ser Lys 
    370                 375                 380                 


Ile Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr Gln 
385                 390                 395                 400 


Arg Asp Tyr Ile Asp His Gln Asp Ile Ile Gly Trp Thr Arg Glu Gly 
                405                 410                 415     


Ile Asp Ala Lys Pro Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly 
            420                 425                 430         


Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Arg His Ala Gly Lys 
        435                 440                 445             


Val Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile Asn 
    450                 455                 460                 


Ala Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser Ile 
465                 470                 475                 480 


Trp Val Ala Lys 
                


<210>  92
<211>  483
<212>  PRT
<213>  Artifical Sequence

<400>  92

Asn Thr Ala Pro Val Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Asp 
1               5                   10                  15      


Leu Pro Asn Asp Gly Thr Leu Trp Thr Lys Val Lys Asn Glu Ala Ser 
            20                  25                  30          


Ser Leu Ser Ala Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Gln Ala Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Ile Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Thr Gln Tyr Leu Gln Ala Ile Gln Ala Ala Lys Ser Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Lys Ala Gly Ala Asp 
            100                 105                 110         


Gly Thr Glu Phe Val Asp Ala Val Glu Val Asp Pro Ser Asn Arg Asn 
        115                 120                 125             


Gln Glu Thr Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Glu Ser Arg Lys Leu Asn Arg Ile 
                165                 170                 175     


Tyr Lys Phe Ser Thr Gly Lys Ala Trp Asp Trp Glu Val Asp Thr Glu 
            180                 185                 190         


Asn Gly Asn Tyr Asp Tyr Leu Met Phe Ala Asp Leu Asp Met Asp His 
        195                 200                 205             


Pro Glu Val Val Ala Glu Leu Lys Asn Trp Gly Lys Trp Tyr Val Asn 
    210                 215                 220                 


Thr Thr Asn Val Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile Lys 
225                 230                 235                 240 


Tyr Ser Phe Phe Pro Asp Trp Leu Ser Tyr Val Arg Asn Gln Thr Gly 
                245                 250                 255     


Lys Asn Leu Phe Ala Val Gly Glu Phe Trp Gly Tyr Asp Val Asn Lys 
            260                 265                 270         


Leu His Asn Tyr Ile Thr Lys Thr Asn Gly Ala Met Ser Leu Phe Asp 
        275                 280                 285             


Ala Pro Leu His Asn Asn Phe Tyr Ile Ala Ser Lys Ser Ser Gly Tyr 
    290                 295                 300                 


Phe Asp Met Arg Tyr Leu Leu Asn Asn Thr Leu Met Lys Asp Gln Pro 
305                 310                 315                 320 


Ala Leu Ala Val Thr Leu Val Asp Asn His Asp Thr Gln Pro Gly Gln 
                325                 330                 335     


Ser Leu Gln Ser Trp Val Glu Pro Trp Phe Lys Pro Leu Ala Tyr Ala 
            340                 345                 350         


Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr Gly Asp 
        355                 360                 365             


Tyr Tyr Gly Ile Pro Lys Tyr Asn Ile Pro Gly Leu Lys Ser Lys Ile 
    370                 375                 380                 


Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr Gln Arg 
385                 390                 395                 400 


Asp Tyr Ile Asp His Gln Asp Ile Ile Gly Trp Thr Arg Glu Gly Ile 
                405                 410                 415     


Asp Ala Lys Pro Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly Pro 
            420                 425                 430         


Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Arg His Ala Gly Lys Val 
        435                 440                 445             


Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile Asn Ala 
    450                 455                 460                 


Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser Ile Trp 
465                 470                 475                 480 


Val Ala Lys 
            


<210>  93
<211>  484
<212>  PRT
<213>  Artifiical Sequence

<400>  93

Asn Thr Ala Pro Val Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Asp 
1               5                   10                  15      


Leu Pro Asn Asp Gly Thr Leu Trp Thr Lys Val Lys Asn Glu Ala Ser 
            20                  25                  30          


Ser Leu Ser Ala Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Gln Ala Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Ile Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Thr Gln Tyr Leu Gln Ala Ile Gln Ala Ala Lys Ser Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Lys Ala Gly Ala Asp 
            100                 105                 110         


Gly Thr Glu Phe Val Asp Ala Val Glu Val Asn Pro Ser Asn Arg Asn 
        115                 120                 125             


Gln Glu Thr Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Glu Ser Arg Lys Leu Asn Arg Ile 
                165                 170                 175     


Tyr Lys Phe Arg Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Asp Thr 
            180                 185                 190         


Glu Asn Gly Asn Tyr Asp Tyr Leu Met Phe Ala Asp Leu Asp Met Asp 
        195                 200                 205             


His Pro Glu Val Val Ala Glu Leu Lys Asn Trp Gly Lys Trp Tyr Val 
    210                 215                 220                 


Asn Thr Thr Asn Val Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile 
225                 230                 235                 240 


Lys Tyr Ser Phe Phe Pro Asp Trp Leu Ser Tyr Val Arg Asn Gln Thr 
                245                 250                 255     


Gly Lys Asn Leu Phe Ala Val Gly Glu Phe Trp Gly Tyr Asp Val Asn 
            260                 265                 270         


Lys Leu His Asn Tyr Ile Thr Lys Thr Asn Gly Ala Met Ser Leu Phe 
        275                 280                 285             


Asp Ala Pro Leu His Asn Asn Phe Tyr Ile Ala Ser Lys Ser Ser Gly 
    290                 295                 300                 


Tyr Phe Asp Met Arg Tyr Leu Leu Asn Asn Thr Leu Met Lys Asp Gln 
305                 310                 315                 320 


Pro Ala Leu Ala Val Thr Leu Val Asp Asn His Asp Thr Gln Pro Gly 
                325                 330                 335     


Gln Ser Leu Gln Ser Trp Val Glu Pro Trp Phe Lys Pro Leu Ala Tyr 
            340                 345                 350         


Ala Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr Gly 
        355                 360                 365             


Asp Tyr Tyr Gly Ile Pro Lys Tyr Asn Ile Pro Gly Leu Lys Ser Lys 
    370                 375                 380                 


Ile Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr Gln 
385                 390                 395                 400 


Arg Asp Tyr Ile Asp His Gln Asp Ile Ile Gly Trp Thr Arg Glu Gly 
                405                 410                 415     


Ile Asp Ala Lys Pro Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly 
            420                 425                 430         


Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Arg His Ala Gly Lys 
        435                 440                 445             


Val Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile Asn 
    450                 455                 460                 


Ala Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser Ile 
465                 470                 475                 480 


Trp Val Ala Lys 
                


<210>  94
<211>  484
<212>  PRT
<213>  Artifiical Sequence

<400>  94

Asn Thr Ala Pro Val Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Asp 
1               5                   10                  15      


Leu Pro Asn Asp Gly Thr Leu Trp Thr Lys Val Lys Asn Glu Ala Ser 
            20                  25                  30          


Ser Leu Ser Ala Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Gln Ala Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Ile Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Thr Gln Tyr Leu Gln Ala Ile Gln Ala Ala Lys Ser Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Lys Ala Gly Ala Asp 
            100                 105                 110         


Ala Thr Glu Trp Val Asp Ala Val Glu Val Asn Pro Ser Asn Arg Asn 
        115                 120                 125             


Gln Glu Val Ser Gly Thr Tyr Lys Ile Gln Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Gln Ser Arg Gln Leu Asn Arg Ile 
                165                 170                 175     


Tyr Lys Phe Arg Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Asp Thr 
            180                 185                 190         


Glu Asn Gly Asn Tyr Asp Tyr Leu Met Phe Ala Asp Leu Asp Met Asp 
        195                 200                 205             


His Pro Glu Val Val Ala Glu Leu Lys Asn Trp Gly Lys Trp Tyr Val 
    210                 215                 220                 


Asn Thr Thr Asn Val Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile 
225                 230                 235                 240 


Lys Tyr Ser Phe Phe Pro Asp Trp Leu Ser Tyr Val Arg Asn Gln Thr 
                245                 250                 255     


Gly Lys Asn Leu Phe Ala Val Gly Glu Phe Trp Gly Tyr Asp Val Asn 
            260                 265                 270         


Lys Leu His Asn Tyr Ile Thr Lys Thr Asn Gly Ala Met Ser Leu Phe 
        275                 280                 285             


Asp Ala Pro Leu His Asn Asn Phe Tyr Ile Ala Ser Lys Ser Ser Gly 
    290                 295                 300                 


Tyr Phe Asp Met Arg Tyr Leu Leu Asn Asn Thr Leu Met Lys Asp Gln 
305                 310                 315                 320 


Pro Ala Leu Ala Val Thr Leu Val Asp Asn His Asp Thr Gln Pro Gly 
                325                 330                 335     


Gln Ser Leu Gln Ser Trp Val Glu Pro Trp Phe Lys Pro Leu Ala Tyr 
            340                 345                 350         


Ala Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr Gly 
        355                 360                 365             


Asp Tyr Tyr Gly Ile Pro Lys Tyr Asn Ile Pro Gly Leu Lys Ser Lys 
    370                 375                 380                 


Ile Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr Gln 
385                 390                 395                 400 


Arg Asp Tyr Ile Asp His Gln Asp Ile Ile Gly Trp Thr Arg Glu Gly 
                405                 410                 415     


Ile Asp Ala Lys Pro Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly 
            420                 425                 430         


Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Arg His Ala Gly Lys 
        435                 440                 445             


Val Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile Asn 
    450                 455                 460                 


Ala Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser Ile 
465                 470                 475                 480 


Trp Val Ala Lys 
                


<210>  95
<211>  485
<212>  PRT
<213>  Artifiical Sequence

<400>  95

Asn Thr Ala Pro Val Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Asp 
1               5                   10                  15      


Leu Pro Asn Asp Gly Thr Leu Trp Thr Lys Val Lys Asn Glu Ala Ser 
            20                  25                  30          


Ser Leu Ser Ala Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Gln Ala Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Ile Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Thr Gln Tyr Leu Gln Ala Ile Gln Ala Ala Lys Ser Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Lys Gly Gly Ala Asp 
            100                 105                 110         


Phe Thr Glu Arg Val Gln Ala Val Glu Val Asn Pro Gln Asn Arg Asn 
        115                 120                 125             


Gln Glu Val Ser Gly Thr Tyr Gln Ile Glu Ala Trp Thr Gly Phe Asn 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Gln His Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Gln Ser Arg Gln Leu Ala Asn Arg 
                165                 170                 175     


Ile Tyr Lys Phe Arg Gly Asp Gly Lys Ala Trp Asp Trp Glu Val Asp 
            180                 185                 190         


Thr Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Val Asp Met 
        195                 200                 205             


Asp His Pro Glu Val Val Ala Glu Leu Lys Asn Trp Gly Lys Trp Tyr 
    210                 215                 220                 


Val Asn Thr Thr Asn Val Asp Gly Phe Arg Leu Asp Ala Val Lys His 
225                 230                 235                 240 


Ile Lys Tyr Ser Phe Phe Pro Asp Trp Leu Ser Tyr Val Arg Asn Gln 
                245                 250                 255     


Thr Gly Lys Asn Leu Phe Ala Val Gly Glu Phe Trp Gly Tyr Asp Val 
            260                 265                 270         


Asn Lys Leu His Asn Tyr Ile Thr Lys Thr Asn Gly Ala Met Ser Leu 
        275                 280                 285             


Phe Asp Ala Pro Leu His Asn Asn Phe Tyr Ile Ala Ser Lys Ser Ser 
    290                 295                 300                 


Gly Tyr Phe Asp Met Arg Tyr Leu Leu Asn Asn Thr Leu Met Lys Asp 
305                 310                 315                 320 


Gln Pro Ala Leu Ala Val Thr Leu Val Asp Asn His Asp Thr Gln Pro 
                325                 330                 335     


Gly Gln Ser Leu Gln Ser Trp Val Glu Pro Trp Phe Lys Pro Leu Ala 
            340                 345                 350         


Tyr Ala Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr 
        355                 360                 365             


Gly Asp Tyr Tyr Gly Ile Pro Lys Tyr Asn Ile Pro Gly Leu Lys Ser 
    370                 375                 380                 


Lys Ile Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr 
385                 390                 395                 400 


Gln Arg Asp Tyr Ile Asp His Gln Asp Ile Ile Gly Trp Thr Arg Glu 
                405                 410                 415     


Gly Ile Asp Ala Lys Pro Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp 
            420                 425                 430         


Gly Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Arg His Ala Gly 
        435                 440                 445             


Lys Val Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile 
    450                 455                 460                 


Asn Ala Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser 
465                 470                 475                 480 


Ile Trp Val Ala Lys 
                485 


<210>  96
<211>  485
<212>  PRT
<213>  Artifical Sequence

<400>  96

Asn Thr Ala Pro Val Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Asp 
1               5                   10                  15      


Leu Pro Asn Asp Gly Thr Leu Trp Thr Lys Val Lys Asn Glu Ala Ser 
            20                  25                  30          


Ser Leu Ser Ala Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Gln Ala Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Ile Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Thr Gln Tyr Leu Gln Ala Ile Gln Ala Ala Lys Ser Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Lys Gly Gly Ala Asp 
            100                 105                 110         


Ala Thr Glu Asn Val Leu Ala Val Glu Val Asn Pro Asn Asn Arg Asn 
        115                 120                 125             


Gln Glu Ile Ser Gly Asp Tyr Thr Ile Glu Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Asp Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Val Asp Trp Asp Gln Ser Arg Gln Phe Gln Asn Arg 
                165                 170                 175     


Ile Tyr Lys Phe Arg Gly Asp Gly Lys Ala Trp Asp Trp Glu Val Asp 
            180                 185                 190         


Ser Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Val Asp Met 
        195                 200                 205             


Asp His Pro Glu Val Val Ala Glu Leu Lys Asn Trp Gly Lys Trp Tyr 
    210                 215                 220                 


Val Asn Thr Thr Asn Val Asp Gly Phe Arg Leu Asp Ala Val Lys His 
225                 230                 235                 240 


Ile Lys Tyr Ser Phe Phe Pro Asp Trp Leu Ser Tyr Val Arg Asn Gln 
                245                 250                 255     


Thr Gly Lys Asn Leu Phe Ala Val Gly Glu Phe Trp Gly Tyr Asp Val 
            260                 265                 270         


Asn Lys Leu His Asn Tyr Ile Thr Lys Thr Asn Gly Ala Met Ser Leu 
        275                 280                 285             


Phe Asp Ala Pro Leu His Asn Asn Phe Tyr Ile Ala Ser Lys Ser Ser 
    290                 295                 300                 


Gly Tyr Phe Asp Met Arg Tyr Leu Leu Asn Asn Thr Leu Met Lys Asp 
305                 310                 315                 320 


Gln Pro Ala Leu Ala Val Thr Leu Val Asp Asn His Asp Thr Gln Pro 
                325                 330                 335     


Gly Gln Ser Leu Gln Ser Trp Val Glu Pro Trp Phe Lys Pro Leu Ala 
            340                 345                 350         


Tyr Ala Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr 
        355                 360                 365             


Gly Asp Tyr Tyr Gly Ile Pro Lys Tyr Asn Ile Pro Gly Leu Lys Ser 
    370                 375                 380                 


Lys Ile Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr 
385                 390                 395                 400 


Gln Arg Asp Tyr Ile Asp His Gln Asp Ile Ile Gly Trp Thr Arg Glu 
                405                 410                 415     


Gly Ile Asp Ala Lys Pro Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp 
            420                 425                 430         


Gly Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Arg His Ala Gly 
        435                 440                 445             


Lys Val Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile 
    450                 455                 460                 


Asn Ala Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser 
465                 470                 475                 480 


Ile Trp Val Ala Lys 
                485 


<210>  97
<211>  485
<212>  PRT
<213>  Artifical Sequence

<400>  97

Asn Thr Ala Pro Val Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Asp 
1               5                   10                  15      


Leu Pro Asn Asp Gly Thr Leu Trp Thr Lys Val Lys Asn Glu Ala Ser 
            20                  25                  30          


Ser Leu Ser Ala Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Gln Ala Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Ile Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Thr Gln Tyr Leu Gln Ala Ile Gln Ala Ala Lys Ser Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Lys Gly Gly Ala Asp 
            100                 105                 110         


Ala Thr Glu Met Val Arg Ala Val Glu Val Asn Pro Asn Asn Arg Asn 
        115                 120                 125             


Gln Glu Val Ser Gly Glu Tyr Thr Ile Glu Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr His Ser Asn Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Val Asp Trp Asp Gln Ser Arg Lys Leu Asn Asn Arg 
                165                 170                 175     


Ile Tyr Lys Phe Arg Gly Asp Gly Lys Gly Trp Asp Trp Glu Val Asp 
            180                 185                 190         


Thr Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Ile Asp Met 
        195                 200                 205             


Asp His Pro Glu Val Val Ala Glu Leu Lys Asn Trp Gly Lys Trp Tyr 
    210                 215                 220                 


Val Asn Thr Thr Asn Val Asp Gly Phe Arg Leu Asp Ala Val Lys His 
225                 230                 235                 240 


Ile Lys Tyr Ser Phe Phe Pro Asp Trp Leu Ser Tyr Val Arg Asn Gln 
                245                 250                 255     


Thr Gly Lys Asn Leu Phe Ala Val Gly Glu Phe Trp Gly Tyr Asp Val 
            260                 265                 270         


Asn Lys Leu His Asn Tyr Ile Thr Lys Thr Asn Gly Ala Met Ser Leu 
        275                 280                 285             


Phe Asp Ala Pro Leu His Asn Asn Phe Tyr Ile Ala Ser Lys Ser Ser 
    290                 295                 300                 


Gly Tyr Phe Asp Met Arg Tyr Leu Leu Asn Asn Thr Leu Met Lys Asp 
305                 310                 315                 320 


Gln Pro Ala Leu Ala Val Thr Leu Val Asp Asn His Asp Thr Gln Pro 
                325                 330                 335     


Gly Gln Ser Leu Gln Ser Trp Val Glu Pro Trp Phe Lys Pro Leu Ala 
            340                 345                 350         


Tyr Ala Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr 
        355                 360                 365             


Gly Asp Tyr Tyr Gly Ile Pro Lys Tyr Asn Ile Pro Gly Leu Lys Ser 
    370                 375                 380                 


Lys Ile Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr 
385                 390                 395                 400 


Gln Arg Asp Tyr Ile Asp His Gln Asp Ile Ile Gly Trp Thr Arg Glu 
                405                 410                 415     


Gly Ile Asp Ala Lys Pro Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp 
            420                 425                 430         


Gly Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Arg His Ala Gly 
        435                 440                 445             


Lys Val Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile 
    450                 455                 460                 


Asn Ala Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser 
465                 470                 475                 480 


Ile Trp Val Ala Lys 
                485 


<210>  98
<211>  485
<212>  PRT
<213>  Artifiical Sequence

<400>  98

Asn Thr Ala Pro Val Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Asp 
1               5                   10                  15      


Leu Pro Asn Asp Gly Thr Leu Trp Thr Lys Val Lys Asn Glu Ala Ser 
            20                  25                  30          


Ser Leu Ser Ala Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Gln Ala Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Ile Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Thr Gln Tyr Leu Gln Ala Ile Gln Ala Ala Lys Ser Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asn His Lys Gly Gly Ala Asp 
            100                 105                 110         


Ala Thr Glu Met Val Arg Ala Val Glu Val Asn Pro Asn Asn Arg Asn 
        115                 120                 125             


Gln Glu Val Thr Gly Glu Tyr Thr Ile Glu Ala Trp Thr Arg Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr His Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Val Asp Trp Asp Gln Ser Arg Arg Leu Asn Asn Arg 
                165                 170                 175     


Ile Tyr Lys Phe Arg Gly His Gly Lys Ala Trp Asp Trp Glu Val Asp 
            180                 185                 190         


Thr Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Ile Asp Met 
        195                 200                 205             


Asp His Pro Glu Val Val Ala Glu Leu Lys Asn Trp Gly Lys Trp Tyr 
    210                 215                 220                 


Val Asn Thr Thr Asn Val Asp Gly Phe Arg Leu Asp Ala Val Lys His 
225                 230                 235                 240 


Ile Lys Tyr Ser Phe Phe Pro Asp Trp Leu Ser Tyr Val Arg Asn Gln 
                245                 250                 255     


Thr Gly Lys Asn Leu Phe Ala Val Gly Glu Phe Trp Gly Tyr Asp Val 
            260                 265                 270         


Asn Lys Leu His Asn Tyr Ile Thr Lys Thr Asn Gly Ala Met Ser Leu 
        275                 280                 285             


Phe Asp Ala Pro Leu His Asn Asn Phe Tyr Ile Ala Ser Lys Ser Ser 
    290                 295                 300                 


Gly Tyr Phe Asp Met Arg Tyr Leu Leu Asn Asn Thr Leu Met Lys Asp 
305                 310                 315                 320 


Gln Pro Ala Leu Ala Val Thr Leu Val Asp Asn His Asp Thr Gln Pro 
                325                 330                 335     


Gly Gln Ser Leu Gln Ser Trp Val Glu Pro Trp Phe Lys Pro Leu Ala 
            340                 345                 350         


Tyr Ala Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr 
        355                 360                 365             


Gly Asp Tyr Tyr Gly Ile Pro Lys Tyr Asn Ile Pro Gly Leu Lys Ser 
    370                 375                 380                 


Lys Ile Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr 
385                 390                 395                 400 


Gln Arg Asp Tyr Ile Asp His Gln Asp Ile Ile Gly Trp Thr Arg Glu 
                405                 410                 415     


Gly Ile Asp Ala Lys Pro Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp 
            420                 425                 430         


Gly Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Arg His Ala Gly 
        435                 440                 445             


Lys Val Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile 
    450                 455                 460                 


Asn Ala Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser 
465                 470                 475                 480 


Ile Trp Val Ala Lys 
                485 


<210>  99
<211>  484
<212>  PRT
<213>  Artifiical Sequence

<400>  99

Val Asn Gly Thr Leu Met Gln Tyr Phe Glu Trp Tyr Thr Pro Asn Asp 
1               5                   10                  15      


Gly Gln His Trp Lys Arg Leu Gln Asn Asp Ala Glu His Leu Ser Asp 
            20                  25                  30          


Ile Gly Ile Thr Ala Val Trp Ile Pro Pro Ala Tyr Lys Gly Leu Ser 
        35                  40                  45              


Gln Ser Asp Asn Gly Tyr Gly Pro Tyr Asp Leu Tyr Asp Leu Gly Glu 
    50                  55                  60                  


Phe Gln Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly Thr Lys Ser Glu 
65                  70                  75                  80  


Leu Gln Asp Ala Ile Gly Ser Leu His Ser Arg Asn Val Gln Val Tyr 
                85                  90                  95      


Gly Asp Val Val Leu Asn His Arg Met Gly Ala Asp Ala Thr Glu Thr 
            100                 105                 110         


Ile Ser Ala Val Glu Val Asn Pro Ser Asn Arg Asn Gln Val Thr Ser 
        115                 120                 125             


Gly Ala Tyr Asn Ile Ser Ala Trp Thr Asp Phe Glu Phe Pro Gly Arg 
    130                 135                 140                 


Gly Asn Thr Tyr Ser Ser Phe Lys Trp His Ser Tyr Tyr Phe Asp Gly 
145                 150                 155                 160 


Val Asp Trp Asp Gln Ser Arg Gln Leu Ser Gly Lys Ile Tyr Gln Ile 
                165                 170                 175     


Gln Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Asp Ser Glu Asn Gly 
            180                 185                 190         


Asn Tyr Asp Tyr Leu Met Gly Ala Asp Ile Asp Tyr Asp His Pro Asp 
        195                 200                 205             


Val Val Ala Glu Thr Lys Lys Trp Gly Ile Trp Tyr Ala Asn Glu Leu 
    210                 215                 220                 


Ser Leu Asp Gly Phe Arg Ile Asp Ala Ala Lys His Ile Lys Phe Ser 
225                 230                 235                 240 


Phe Leu Arg Asp Trp Val Gln Ala Val Arg Gln Ala Thr Gly Lys Glu 
                245                 250                 255     


Met Phe Thr Val Ala Glu Tyr Trp Gln Asn Asn Ala Gly Lys Leu Glu 
            260                 265                 270         


Asn Tyr Leu Asn Lys Thr Ser Phe Asn Gln Ser Val Phe Asp Val Pro 
        275                 280                 285             


Leu His Phe Asn Leu Gln Ala Ala Ser Ser Gln Gly Gly Gly Tyr Asp 
    290                 295                 300                 


Met Arg Arg Leu Leu Asp Gly Thr Val Val Ser Arg His Pro Glu Lys 
305                 310                 315                 320 


Ala Val Thr Phe Val Glu Asn His Asp Thr Gln Pro Gly Gln Ser Leu 
                325                 330                 335     


Glu Ser Thr Val Gln Thr Trp Phe Lys Pro Leu Ala Tyr Ala Phe Ile 
            340                 345                 350         


Leu Thr Arg Glu Ser Gly Tyr Pro Gln Val Phe Tyr Gly Asp Met Tyr 
        355                 360                 365             


Gly Thr Lys Gly Thr Ser Pro Lys Glu Ile Pro Ser Leu Lys Asp Asn 
    370                 375                 380                 


Ile Glu Pro Ile Leu Lys Ala Arg Lys Glu Tyr Ala Tyr Gly Pro Gln 
385                 390                 395                 400 


His Asp Tyr Ile Asp His Pro Asp Val Ile Gly Trp Thr Arg Glu Gly 
                405                 410                 415     


Asp Ser Ser Ala Ala Lys Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly 
            420                 425                 430         


Pro Gly Gly Ser Lys Arg Met Tyr Ala Gly Leu Lys Asn Ala Gly Glu 
        435                 440                 445             


Thr Trp Tyr Asp Ile Thr Gly Asn Arg Ser Asp Thr Val Lys Ile Gly 
    450                 455                 460                 


Ser Asp Gly Trp Gly Glu Phe His Val Asn Asp Gly Ser Val Ser Ile 
465                 470                 475                 480 


Tyr Val Gln Lys 
                


<210>  100
<211>  481
<212>  PRT
<213>  Artifiical Sequence

<400>  100

Val Asn Gly Thr Leu Met Gln Tyr Phe Glu Trp Tyr Thr Pro Asn Asp 
1               5                   10                  15      


Gly Gln His Trp Lys Arg Leu Gln Asn Asp Ala Glu His Leu Ser Asp 
            20                  25                  30          


Ile Gly Ile Thr Ala Val Trp Ile Pro Pro Ala Tyr Lys Gly Leu Ser 
        35                  40                  45              


Gln Ser Asp Asn Gly Tyr Gly Pro Tyr Asp Leu Tyr Asp Leu Gly Glu 
    50                  55                  60                  


Phe Gln Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly Thr Lys Ser Glu 
65                  70                  75                  80  


Leu Gln Asp Ala Ile Gly Ser Leu His Ser Arg Asn Val Gln Val Tyr 
                85                  90                  95      


Gly Asp Val Val Leu Asn His Lys Gly Gly Ala Asp Ala Thr Glu Asp 
            100                 105                 110         


Val Thr Ala Val Glu Val Asp Pro Ala Asp Arg Asn Arg Val Ile Ser 
        115                 120                 125             


Gly Glu His Leu Ile Lys Ala Trp Thr His Phe His Phe Pro Gly Arg 
    130                 135                 140                 


Gly Ser Thr Tyr Ser Asp Phe Lys Trp His Trp Tyr His Phe Asp Gly 
145                 150                 155                 160 


Thr Asp Trp Asp Glu Ser Arg Lys Leu Asn Arg Ile Tyr Lys Phe Gln 
                165                 170                 175     


Gly Lys Ala Trp Asp Trp Glu Val Ser Asn Glu Phe Gly Asn Tyr Asp 
            180                 185                 190         


Tyr Leu Met Tyr Ala Asp Ile Asp Tyr Asp His Pro Asp Val Val Ala 
        195                 200                 205             


Glu Thr Lys Lys Trp Gly Ile Trp Tyr Ala Asn Glu Leu Ser Leu Asp 
    210                 215                 220                 


Gly Phe Arg Ile Asp Ala Ala Lys His Ile Lys Phe Ser Phe Leu Arg 
225                 230                 235                 240 


Asp Trp Val Gln Ala Val Arg Gln Ala Thr Gly Lys Glu Met Phe Thr 
                245                 250                 255     


Val Ala Glu Tyr Trp Gln Asn Asn Ala Gly Lys Leu Glu Asn Tyr Leu 
            260                 265                 270         


Asn Lys Thr Ser Phe Asn Gln Ser Val Phe Asp Val Pro Leu His Phe 
        275                 280                 285             


Asn Leu Gln Ala Ala Ser Ser Gln Gly Gly Gly Tyr Asp Met Arg Arg 
    290                 295                 300                 


Leu Leu Asp Gly Thr Val Val Ser Arg His Pro Glu Lys Ala Val Thr 
305                 310                 315                 320 


Phe Val Glu Asn His Asp Thr Gln Pro Gly Gln Ser Leu Glu Ser Thr 
                325                 330                 335     


Val Gln Thr Trp Phe Lys Pro Leu Ala Tyr Ala Phe Ile Leu Thr Arg 
            340                 345                 350         


Glu Ser Gly Tyr Pro Gln Val Phe Tyr Gly Asp Met Tyr Gly Thr Lys 
        355                 360                 365             


Gly Thr Ser Pro Lys Glu Ile Pro Ser Leu Lys Asp Asn Ile Glu Pro 
    370                 375                 380                 


Ile Leu Lys Ala Arg Lys Glu Tyr Ala Tyr Gly Pro Gln His Asp Tyr 
385                 390                 395                 400 


Ile Asp His Pro Asp Val Ile Gly Trp Thr Arg Glu Gly Asp Ser Ser 
                405                 410                 415     


Ala Ala Lys Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly Pro Gly Gly 
            420                 425                 430         


Ser Lys Arg Met Tyr Ala Gly Leu Lys Asn Ala Gly Glu Thr Trp Tyr 
        435                 440                 445             


Asp Ile Thr Gly Asn Arg Ser Asp Thr Val Lys Ile Gly Ser Asp Gly 
    450                 455                 460                 


Trp Gly Glu Phe His Val Asn Asp Gly Ser Val Ser Ile Tyr Val Gln 
465                 470                 475                 480 


Lys 
    


<210>  101
<211>  483
<212>  PRT
<213>  Artifical Sequence

<400>  101

Val Asn Gly Thr Leu Met Gln Tyr Phe Glu Trp Tyr Thr Pro Asn Asp 
1               5                   10                  15      


Gly Gln His Trp Lys Arg Leu Gln Asn Asp Ala Glu His Leu Ser Asp 
            20                  25                  30          


Ile Gly Ile Thr Ala Val Trp Ile Pro Pro Ala Tyr Lys Gly Leu Ser 
        35                  40                  45              


Gln Ser Asp Asn Gly Tyr Gly Pro Tyr Asp Leu Tyr Asp Leu Gly Glu 
    50                  55                  60                  


Phe Gln Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly Thr Lys Ser Glu 
65                  70                  75                  80  


Leu Gln Asp Ala Ile Gly Ser Leu His Ser Arg Asn Val Gln Val Tyr 
                85                  90                  95      


Gly Asp Val Val Leu Asn His Lys Ala Gly Ala Asp Tyr Thr Glu Asn 
            100                 105                 110         


Val Thr Ala Val Glu Val Asn Pro Ser Asn Arg Asn Gln Glu Thr Ser 
        115                 120                 125             


Gly Glu Tyr Asn Ile Gln Ala Trp Thr Gly Phe Asn Phe Pro Gly Arg 
    130                 135                 140                 


Gly Thr Thr Tyr Ser Asn Phe Lys Trp Gln Trp Phe His Phe Asp Gly 
145                 150                 155                 160 


Thr Asp Trp Asp Gln Ser Arg Ser Leu Ser Arg Ile Phe Lys Phe Arg 
                165                 170                 175     


Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Ser Ser Glu Asn Gly Asn 
            180                 185                 190         


Tyr Asp Tyr Leu Met Tyr Ala Asp Ile Asp Tyr Asp His Pro Asp Val 
        195                 200                 205             


Val Ala Glu Thr Lys Lys Trp Gly Ile Trp Tyr Ala Asn Glu Leu Ser 
    210                 215                 220                 


Leu Asp Gly Phe Arg Ile Asp Ala Ala Lys His Ile Lys Phe Ser Phe 
225                 230                 235                 240 


Leu Arg Asp Trp Val Gln Ala Val Arg Gln Ala Thr Gly Lys Glu Met 
                245                 250                 255     


Phe Thr Val Ala Glu Tyr Trp Gln Asn Asn Ala Gly Lys Leu Glu Asn 
            260                 265                 270         


Tyr Leu Asn Lys Thr Ser Phe Asn Gln Ser Val Phe Asp Val Pro Leu 
        275                 280                 285             


His Phe Asn Leu Gln Ala Ala Ser Ser Gln Gly Gly Gly Tyr Asp Met 
    290                 295                 300                 


Arg Arg Leu Leu Asp Gly Thr Val Val Ser Arg His Pro Glu Lys Ala 
305                 310                 315                 320 


Val Thr Phe Val Glu Asn His Asp Thr Gln Pro Gly Gln Ser Leu Glu 
                325                 330                 335     


Ser Thr Val Gln Thr Trp Phe Lys Pro Leu Ala Tyr Ala Phe Ile Leu 
            340                 345                 350         


Thr Arg Glu Ser Gly Tyr Pro Gln Val Phe Tyr Gly Asp Met Tyr Gly 
        355                 360                 365             


Thr Lys Gly Thr Ser Pro Lys Glu Ile Pro Ser Leu Lys Asp Asn Ile 
    370                 375                 380                 


Glu Pro Ile Leu Lys Ala Arg Lys Glu Tyr Ala Tyr Gly Pro Gln His 
385                 390                 395                 400 


Asp Tyr Ile Asp His Pro Asp Val Ile Gly Trp Thr Arg Glu Gly Asp 
                405                 410                 415     


Ser Ser Ala Ala Lys Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly Pro 
            420                 425                 430         


Gly Gly Ser Lys Arg Met Tyr Ala Gly Leu Lys Asn Ala Gly Glu Thr 
        435                 440                 445             


Trp Tyr Asp Ile Thr Gly Asn Arg Ser Asp Thr Val Lys Ile Gly Ser 
    450                 455                 460                 


Asp Gly Trp Gly Glu Phe His Val Asn Asp Gly Ser Val Ser Ile Tyr 
465                 470                 475                 480 


Val Gln Lys 
            


<210>  102
<211>  483
<212>  PRT
<213>  Artifical Sequence

<400>  102

Val Asn Gly Thr Leu Met Gln Tyr Phe Glu Trp Tyr Thr Pro Asn Asp 
1               5                   10                  15      


Gly Gln His Trp Lys Arg Leu Gln Asn Asp Ala Glu His Leu Ser Asp 
            20                  25                  30          


Ile Gly Ile Thr Ala Val Trp Ile Pro Pro Ala Tyr Lys Gly Leu Ser 
        35                  40                  45              


Gln Ser Asp Asn Gly Tyr Gly Pro Tyr Asp Leu Tyr Asp Leu Gly Glu 
    50                  55                  60                  


Phe Gln Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly Thr Lys Ser Glu 
65                  70                  75                  80  


Leu Gln Asp Ala Ile Gly Ser Leu His Ser Arg Asn Val Gln Val Tyr 
                85                  90                  95      


Gly Asp Val Val Leu Asp His Lys Gly Gly Ala Asp Gly Thr Glu Trp 
            100                 105                 110         


Val Asp Ala Val Glu Val Asn Pro Ser Asp Arg Asn Gln Glu Ile Ser 
        115                 120                 125             


Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp Phe Pro Gly Arg 
    130                 135                 140                 


Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr His Phe Asp Gly 
145                 150                 155                 160 


Val Asp Trp Asp Glu Ser Arg Lys Leu Ser Arg Ile Tyr Lys Phe Arg 
                165                 170                 175     


Gly Ile Gly Lys Ala Trp Asp Trp Glu Val Asp Thr Glu Asn Gly Asn 
            180                 185                 190         


Tyr Asp Tyr Leu Met Tyr Ala Asp Leu Asp Tyr Asp His Pro Asp Val 
        195                 200                 205             


Val Ala Glu Thr Lys Lys Trp Gly Ile Trp Tyr Ala Asn Glu Leu Ser 
    210                 215                 220                 


Leu Asp Gly Phe Arg Ile Asp Ala Ala Lys His Ile Lys Phe Ser Phe 
225                 230                 235                 240 


Leu Arg Asp Trp Val Gln Ala Val Arg Gln Ala Thr Gly Lys Glu Met 
                245                 250                 255     


Phe Thr Val Ala Glu Tyr Trp Gln Asn Asn Ala Gly Lys Leu Glu Asn 
            260                 265                 270         


Tyr Leu Asn Lys Thr Ser Phe Asn Gln Ser Val Phe Asp Val Pro Leu 
        275                 280                 285             


His Phe Asn Leu Gln Ala Ala Ser Ser Gln Gly Gly Gly Tyr Asp Met 
    290                 295                 300                 


Arg Arg Leu Leu Asp Gly Thr Val Val Ser Arg His Pro Glu Lys Ala 
305                 310                 315                 320 


Val Thr Phe Val Glu Asn His Asp Thr Gln Pro Gly Gln Ser Leu Glu 
                325                 330                 335     


Ser Thr Val Gln Thr Trp Phe Lys Pro Leu Ala Tyr Ala Phe Ile Leu 
            340                 345                 350         


Thr Arg Glu Ser Gly Tyr Pro Gln Val Phe Tyr Gly Asp Met Tyr Gly 
        355                 360                 365             


Thr Lys Gly Thr Ser Pro Lys Glu Ile Pro Ser Leu Lys Asp Asn Ile 
    370                 375                 380                 


Glu Pro Ile Leu Lys Ala Arg Lys Glu Tyr Ala Tyr Gly Pro Gln His 
385                 390                 395                 400 


Asp Tyr Ile Asp His Pro Asp Val Ile Gly Trp Thr Arg Glu Gly Asp 
                405                 410                 415     


Ser Ser Ala Ala Lys Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly Pro 
            420                 425                 430         


Gly Gly Ser Lys Arg Met Tyr Ala Gly Leu Lys Asn Ala Gly Glu Thr 
        435                 440                 445             


Trp Tyr Asp Ile Thr Gly Asn Arg Ser Asp Thr Val Lys Ile Gly Ser 
    450                 455                 460                 


Asp Gly Trp Gly Glu Phe His Val Asn Asp Gly Ser Val Ser Ile Tyr 
465                 470                 475                 480 


Val Gln Lys 
            


<210>  103
<211>  483
<212>  PRT
<213>  Artifiical Sequence

<400>  103

Val Asn Gly Thr Leu Met Gln Tyr Phe Glu Trp Tyr Thr Pro Asn Asp 
1               5                   10                  15      


Gly Gln His Trp Lys Arg Leu Gln Asn Asp Ala Glu His Leu Ser Asp 
            20                  25                  30          


Ile Gly Ile Thr Ala Val Trp Ile Pro Pro Ala Tyr Lys Gly Leu Ser 
        35                  40                  45              


Gln Ser Asp Asn Gly Tyr Gly Pro Tyr Asp Leu Tyr Asp Leu Gly Glu 
    50                  55                  60                  


Phe Gln Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly Thr Lys Ser Glu 
65                  70                  75                  80  


Leu Gln Asp Ala Ile Gly Ser Leu His Ser Arg Asn Val Gln Val Tyr 
                85                  90                  95      


Gly Asp Val Val Leu Asn His Lys Ala Gly Ala Asp Gly Thr Glu Leu 
            100                 105                 110         


Val Asp Ala Val Glu Val Asn Pro Ser Asp Arg Asn Gln Glu Ile Ser 
        115                 120                 125             


Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp Phe Pro Gly Arg 
    130                 135                 140                 


Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr His Phe Asp Gly 
145                 150                 155                 160 


Thr Asp Trp Asp Glu Ser Arg Lys Leu Asn Arg Ile Tyr Lys Phe Arg 
                165                 170                 175     


Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Asp Thr Glu Asn Gly Asn 
            180                 185                 190         


Tyr Asp Tyr Leu Met Tyr Ala Asp Leu Asp Tyr Asp His Pro Asp Val 
        195                 200                 205             


Val Ala Glu Thr Lys Lys Trp Gly Ile Trp Tyr Ala Asn Glu Leu Ser 
    210                 215                 220                 


Leu Asp Gly Phe Arg Ile Asp Ala Ala Lys His Ile Lys Phe Ser Phe 
225                 230                 235                 240 


Leu Arg Asp Trp Val Gln Ala Val Arg Gln Ala Thr Gly Lys Glu Met 
                245                 250                 255     


Phe Thr Val Ala Glu Tyr Trp Gln Asn Asn Ala Gly Lys Leu Glu Asn 
            260                 265                 270         


Tyr Leu Asn Lys Thr Ser Phe Asn Gln Ser Val Phe Asp Val Pro Leu 
        275                 280                 285             


His Phe Asn Leu Gln Ala Ala Ser Ser Gln Gly Gly Gly Tyr Asp Met 
    290                 295                 300                 


Arg Arg Leu Leu Asp Gly Thr Val Val Ser Arg His Pro Glu Lys Ala 
305                 310                 315                 320 


Val Thr Phe Val Glu Asn His Asp Thr Gln Pro Gly Gln Ser Leu Glu 
                325                 330                 335     


Ser Thr Val Gln Thr Trp Phe Lys Pro Leu Ala Tyr Ala Phe Ile Leu 
            340                 345                 350         


Thr Arg Glu Ser Gly Tyr Pro Gln Val Phe Tyr Gly Asp Met Tyr Gly 
        355                 360                 365             


Thr Lys Gly Thr Ser Pro Lys Glu Ile Pro Ser Leu Lys Asp Asn Ile 
    370                 375                 380                 


Glu Pro Ile Leu Lys Ala Arg Lys Glu Tyr Ala Tyr Gly Pro Gln His 
385                 390                 395                 400 


Asp Tyr Ile Asp His Pro Asp Val Ile Gly Trp Thr Arg Glu Gly Asp 
                405                 410                 415     


Ser Ser Ala Ala Lys Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly Pro 
            420                 425                 430         


Gly Gly Ser Lys Arg Met Tyr Ala Gly Leu Lys Asn Ala Gly Glu Thr 
        435                 440                 445             


Trp Tyr Asp Ile Thr Gly Asn Arg Ser Asp Thr Val Lys Ile Gly Ser 
    450                 455                 460                 


Asp Gly Trp Gly Glu Phe His Val Asn Asp Gly Ser Val Ser Ile Tyr 
465                 470                 475                 480 


Val Gln Lys 
            


<210>  104
<211>  483
<212>  PRT
<213>  Artifical Sequence

<400>  104

Val Asn Gly Thr Leu Met Gln Tyr Phe Glu Trp Tyr Thr Pro Asn Asp 
1               5                   10                  15      


Gly Gln His Trp Lys Arg Leu Gln Asn Asp Ala Glu His Leu Ser Asp 
            20                  25                  30          


Ile Gly Ile Thr Ala Val Trp Ile Pro Pro Ala Tyr Lys Gly Leu Ser 
        35                  40                  45              


Gln Ser Asp Asn Gly Tyr Gly Pro Tyr Asp Leu Tyr Asp Leu Gly Glu 
    50                  55                  60                  


Phe Gln Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly Thr Lys Ser Glu 
65                  70                  75                  80  


Leu Gln Asp Ala Ile Gly Ser Leu His Ser Arg Asn Val Gln Val Tyr 
                85                  90                  95      


Gly Asp Val Val Leu Asn His Lys Ala Gly Ala Asp Gly Thr Glu Phe 
            100                 105                 110         


Val Asp Ala Val Glu Val Asn Pro Ser Asn Arg Asn Gln Glu Thr Ser 
        115                 120                 125             


Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp Phe Pro Gly Arg 
    130                 135                 140                 


Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr His Phe Asp Gly 
145                 150                 155                 160 


Thr Asp Trp Asp Glu Ser Arg Lys Leu Asn Arg Val Tyr Lys Phe Arg 
                165                 170                 175     


Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Asp Thr Glu Asn Gly Asn 
            180                 185                 190         


Tyr Asp Tyr Leu Met Phe Ala Asp Leu Asp Tyr Asp His Pro Asp Val 
        195                 200                 205             


Val Ala Glu Thr Lys Lys Trp Gly Ile Trp Tyr Ala Asn Glu Leu Ser 
    210                 215                 220                 


Leu Asp Gly Phe Arg Ile Asp Ala Ala Lys His Ile Lys Phe Ser Phe 
225                 230                 235                 240 


Leu Arg Asp Trp Val Gln Ala Val Arg Gln Ala Thr Gly Lys Glu Met 
                245                 250                 255     


Phe Thr Val Ala Glu Tyr Trp Gln Asn Asn Ala Gly Lys Leu Glu Asn 
            260                 265                 270         


Tyr Leu Asn Lys Thr Ser Phe Asn Gln Ser Val Phe Asp Val Pro Leu 
        275                 280                 285             


His Phe Asn Leu Gln Ala Ala Ser Ser Gln Gly Gly Gly Tyr Asp Met 
    290                 295                 300                 


Arg Arg Leu Leu Asp Gly Thr Val Val Ser Arg His Pro Glu Lys Ala 
305                 310                 315                 320 


Val Thr Phe Val Glu Asn His Asp Thr Gln Pro Gly Gln Ser Leu Glu 
                325                 330                 335     


Ser Thr Val Gln Thr Trp Phe Lys Pro Leu Ala Tyr Ala Phe Ile Leu 
            340                 345                 350         


Thr Arg Glu Ser Gly Tyr Pro Gln Val Phe Tyr Gly Asp Met Tyr Gly 
        355                 360                 365             


Thr Lys Gly Thr Ser Pro Lys Glu Ile Pro Ser Leu Lys Asp Asn Ile 
    370                 375                 380                 


Glu Pro Ile Leu Lys Ala Arg Lys Glu Tyr Ala Tyr Gly Pro Gln His 
385                 390                 395                 400 


Asp Tyr Ile Asp His Pro Asp Val Ile Gly Trp Thr Arg Glu Gly Asp 
                405                 410                 415     


Ser Ser Ala Ala Lys Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly Pro 
            420                 425                 430         


Gly Gly Ser Lys Arg Met Tyr Ala Gly Leu Lys Asn Ala Gly Glu Thr 
        435                 440                 445             


Trp Tyr Asp Ile Thr Gly Asn Arg Ser Asp Thr Val Lys Ile Gly Ser 
    450                 455                 460                 


Asp Gly Trp Gly Glu Phe His Val Asn Asp Gly Ser Val Ser Ile Tyr 
465                 470                 475                 480 


Val Gln Lys 
            


<210>  105
<211>  482
<212>  PRT
<213>  Artifiical Sequence

<400>  105

Val Asn Gly Thr Leu Met Gln Tyr Phe Glu Trp Tyr Thr Pro Asn Asp 
1               5                   10                  15      


Gly Gln His Trp Lys Arg Leu Gln Asn Asp Ala Glu His Leu Ser Asp 
            20                  25                  30          


Ile Gly Ile Thr Ala Val Trp Ile Pro Pro Ala Tyr Lys Gly Leu Ser 
        35                  40                  45              


Gln Ser Asp Asn Gly Tyr Gly Pro Tyr Asp Leu Tyr Asp Leu Gly Glu 
    50                  55                  60                  


Phe Gln Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly Thr Lys Ser Glu 
65                  70                  75                  80  


Leu Gln Asp Ala Ile Gly Ser Leu His Ser Arg Asn Val Gln Val Tyr 
                85                  90                  95      


Gly Asp Val Val Leu Asn His Lys Ala Gly Ala Asp Gly Thr Glu Phe 
            100                 105                 110         


Val Asp Ala Val Glu Val Asp Pro Ser Asn Arg Asn Gln Glu Thr Ser 
        115                 120                 125             


Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp Phe Pro Gly Arg 
    130                 135                 140                 


Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr His Phe Asp Gly 
145                 150                 155                 160 


Thr Asp Trp Asp Glu Ser Arg Lys Leu Asn Arg Ile Tyr Lys Phe Ser 
                165                 170                 175     


Thr Gly Lys Ala Trp Asp Trp Glu Val Asp Thr Glu Asn Gly Asn Tyr 
            180                 185                 190         


Asp Tyr Leu Met Phe Ala Asp Leu Asp Tyr Asp His Pro Asp Val Val 
        195                 200                 205             


Ala Glu Thr Lys Lys Trp Gly Ile Trp Tyr Ala Asn Glu Leu Ser Leu 
    210                 215                 220                 


Asp Gly Phe Arg Ile Asp Ala Ala Lys His Ile Lys Phe Ser Phe Leu 
225                 230                 235                 240 


Arg Asp Trp Val Gln Ala Val Arg Gln Ala Thr Gly Lys Glu Met Phe 
                245                 250                 255     


Thr Val Ala Glu Tyr Trp Gln Asn Asn Ala Gly Lys Leu Glu Asn Tyr 
            260                 265                 270         


Leu Asn Lys Thr Ser Phe Asn Gln Ser Val Phe Asp Val Pro Leu His 
        275                 280                 285             


Phe Asn Leu Gln Ala Ala Ser Ser Gln Gly Gly Gly Tyr Asp Met Arg 
    290                 295                 300                 


Arg Leu Leu Asp Gly Thr Val Val Ser Arg His Pro Glu Lys Ala Val 
305                 310                 315                 320 


Thr Phe Val Glu Asn His Asp Thr Gln Pro Gly Gln Ser Leu Glu Ser 
                325                 330                 335     


Thr Val Gln Thr Trp Phe Lys Pro Leu Ala Tyr Ala Phe Ile Leu Thr 
            340                 345                 350         


Arg Glu Ser Gly Tyr Pro Gln Val Phe Tyr Gly Asp Met Tyr Gly Thr 
        355                 360                 365             


Lys Gly Thr Ser Pro Lys Glu Ile Pro Ser Leu Lys Asp Asn Ile Glu 
    370                 375                 380                 


Pro Ile Leu Lys Ala Arg Lys Glu Tyr Ala Tyr Gly Pro Gln His Asp 
385                 390                 395                 400 


Tyr Ile Asp His Pro Asp Val Ile Gly Trp Thr Arg Glu Gly Asp Ser 
                405                 410                 415     


Ser Ala Ala Lys Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly Pro Gly 
            420                 425                 430         


Gly Ser Lys Arg Met Tyr Ala Gly Leu Lys Asn Ala Gly Glu Thr Trp 
        435                 440                 445             


Tyr Asp Ile Thr Gly Asn Arg Ser Asp Thr Val Lys Ile Gly Ser Asp 
    450                 455                 460                 


Gly Trp Gly Glu Phe His Val Asn Asp Gly Ser Val Ser Ile Tyr Val 
465                 470                 475                 480 


Gln Lys 
        


<210>  106
<211>  483
<212>  PRT
<213>  Artifiical Sequence

<400>  106

Val Asn Gly Thr Leu Met Gln Tyr Phe Glu Trp Tyr Thr Pro Asn Asp 
1               5                   10                  15      


Gly Gln His Trp Lys Arg Leu Gln Asn Asp Ala Glu His Leu Ser Asp 
            20                  25                  30          


Ile Gly Ile Thr Ala Val Trp Ile Pro Pro Ala Tyr Lys Gly Leu Ser 
        35                  40                  45              


Gln Ser Asp Asn Gly Tyr Gly Pro Tyr Asp Leu Tyr Asp Leu Gly Glu 
    50                  55                  60                  


Phe Gln Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly Thr Lys Ser Glu 
65                  70                  75                  80  


Leu Gln Asp Ala Ile Gly Ser Leu His Ser Arg Asn Val Gln Val Tyr 
                85                  90                  95      


Gly Asp Val Val Leu Asn His Lys Ala Gly Ala Asp Gly Thr Glu Phe 
            100                 105                 110         


Val Asp Ala Val Glu Val Asn Pro Ser Asn Arg Asn Gln Glu Thr Ser 
        115                 120                 125             


Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp Phe Pro Gly Arg 
    130                 135                 140                 


Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr His Phe Asp Gly 
145                 150                 155                 160 


Thr Asp Trp Asp Glu Ser Arg Lys Leu Asn Arg Ile Tyr Lys Phe Arg 
                165                 170                 175     


Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Asp Thr Glu Asn Gly Asn 
            180                 185                 190         


Tyr Asp Tyr Leu Met Phe Ala Asp Leu Asp Tyr Asp His Pro Asp Val 
        195                 200                 205             


Val Ala Glu Thr Lys Lys Trp Gly Ile Trp Tyr Ala Asn Glu Leu Ser 
    210                 215                 220                 


Leu Asp Gly Phe Arg Ile Asp Ala Ala Lys His Ile Lys Phe Ser Phe 
225                 230                 235                 240 


Leu Arg Asp Trp Val Gln Ala Val Arg Gln Ala Thr Gly Lys Glu Met 
                245                 250                 255     


Phe Thr Val Ala Glu Tyr Trp Gln Asn Asn Ala Gly Lys Leu Glu Asn 
            260                 265                 270         


Tyr Leu Asn Lys Thr Ser Phe Asn Gln Ser Val Phe Asp Val Pro Leu 
        275                 280                 285             


His Phe Asn Leu Gln Ala Ala Ser Ser Gln Gly Gly Gly Tyr Asp Met 
    290                 295                 300                 


Arg Arg Leu Leu Asp Gly Thr Val Val Ser Arg His Pro Glu Lys Ala 
305                 310                 315                 320 


Val Thr Phe Val Glu Asn His Asp Thr Gln Pro Gly Gln Ser Leu Glu 
                325                 330                 335     


Ser Thr Val Gln Thr Trp Phe Lys Pro Leu Ala Tyr Ala Phe Ile Leu 
            340                 345                 350         


Thr Arg Glu Ser Gly Tyr Pro Gln Val Phe Tyr Gly Asp Met Tyr Gly 
        355                 360                 365             


Thr Lys Gly Thr Ser Pro Lys Glu Ile Pro Ser Leu Lys Asp Asn Ile 
    370                 375                 380                 


Glu Pro Ile Leu Lys Ala Arg Lys Glu Tyr Ala Tyr Gly Pro Gln His 
385                 390                 395                 400 


Asp Tyr Ile Asp His Pro Asp Val Ile Gly Trp Thr Arg Glu Gly Asp 
                405                 410                 415     


Ser Ser Ala Ala Lys Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly Pro 
            420                 425                 430         


Gly Gly Ser Lys Arg Met Tyr Ala Gly Leu Lys Asn Ala Gly Glu Thr 
        435                 440                 445             


Trp Tyr Asp Ile Thr Gly Asn Arg Ser Asp Thr Val Lys Ile Gly Ser 
    450                 455                 460                 


Asp Gly Trp Gly Glu Phe His Val Asn Asp Gly Ser Val Ser Ile Tyr 
465                 470                 475                 480 


Val Gln Lys 
            


<210>  107
<211>  483
<212>  PRT
<213>  Artifiical Sequence

<400>  107

Val Asn Gly Thr Leu Met Gln Tyr Phe Glu Trp Tyr Thr Pro Asn Asp 
1               5                   10                  15      


Gly Gln His Trp Lys Arg Leu Gln Asn Asp Ala Glu His Leu Ser Asp 
            20                  25                  30          


Ile Gly Ile Thr Ala Val Trp Ile Pro Pro Ala Tyr Lys Gly Leu Ser 
        35                  40                  45              


Gln Ser Asp Asn Gly Tyr Gly Pro Tyr Asp Leu Tyr Asp Leu Gly Glu 
    50                  55                  60                  


Phe Gln Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly Thr Lys Ser Glu 
65                  70                  75                  80  


Leu Gln Asp Ala Ile Gly Ser Leu His Ser Arg Asn Val Gln Val Tyr 
                85                  90                  95      


Gly Asp Val Val Leu Asn His Lys Ala Gly Ala Asp Ala Thr Glu Trp 
            100                 105                 110         


Val Asp Ala Val Glu Val Asn Pro Ser Asn Arg Asn Gln Glu Val Ser 
        115                 120                 125             


Gly Thr Tyr Lys Ile Gln Ala Trp Thr Lys Phe Asp Phe Pro Gly Arg 
    130                 135                 140                 


Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr His Phe Asp Gly 
145                 150                 155                 160 


Thr Asp Trp Asp Gln Ser Arg Gln Leu Asn Arg Ile Tyr Lys Phe Arg 
                165                 170                 175     


Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Asp Thr Glu Asn Gly Asn 
            180                 185                 190         


Tyr Asp Tyr Leu Met Phe Ala Asp Leu Asp Tyr Asp His Pro Asp Val 
        195                 200                 205             


Val Ala Glu Thr Lys Lys Trp Gly Ile Trp Tyr Ala Asn Glu Leu Ser 
    210                 215                 220                 


Leu Asp Gly Phe Arg Ile Asp Ala Ala Lys His Ile Lys Phe Ser Phe 
225                 230                 235                 240 


Leu Arg Asp Trp Val Gln Ala Val Arg Gln Ala Thr Gly Lys Glu Met 
                245                 250                 255     


Phe Thr Val Ala Glu Tyr Trp Gln Asn Asn Ala Gly Lys Leu Glu Asn 
            260                 265                 270         


Tyr Leu Asn Lys Thr Ser Phe Asn Gln Ser Val Phe Asp Val Pro Leu 
        275                 280                 285             


His Phe Asn Leu Gln Ala Ala Ser Ser Gln Gly Gly Gly Tyr Asp Met 
    290                 295                 300                 


Arg Arg Leu Leu Asp Gly Thr Val Val Ser Arg His Pro Glu Lys Ala 
305                 310                 315                 320 


Val Thr Phe Val Glu Asn His Asp Thr Gln Pro Gly Gln Ser Leu Glu 
                325                 330                 335     


Ser Thr Val Gln Thr Trp Phe Lys Pro Leu Ala Tyr Ala Phe Ile Leu 
            340                 345                 350         


Thr Arg Glu Ser Gly Tyr Pro Gln Val Phe Tyr Gly Asp Met Tyr Gly 
        355                 360                 365             


Thr Lys Gly Thr Ser Pro Lys Glu Ile Pro Ser Leu Lys Asp Asn Ile 
    370                 375                 380                 


Glu Pro Ile Leu Lys Ala Arg Lys Glu Tyr Ala Tyr Gly Pro Gln His 
385                 390                 395                 400 


Asp Tyr Ile Asp His Pro Asp Val Ile Gly Trp Thr Arg Glu Gly Asp 
                405                 410                 415     


Ser Ser Ala Ala Lys Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly Pro 
            420                 425                 430         


Gly Gly Ser Lys Arg Met Tyr Ala Gly Leu Lys Asn Ala Gly Glu Thr 
        435                 440                 445             


Trp Tyr Asp Ile Thr Gly Asn Arg Ser Asp Thr Val Lys Ile Gly Ser 
    450                 455                 460                 


Asp Gly Trp Gly Glu Phe His Val Asn Asp Gly Ser Val Ser Ile Tyr 
465                 470                 475                 480 


Val Gln Lys 
            


<210>  108
<211>  483
<212>  PRT
<213>  Artifiical Sequence

<400>  108

Val Asn Gly Thr Leu Met Gln Tyr Phe Glu Trp Tyr Thr Pro Asn Asp 
1               5                   10                  15      


Gly Gln His Trp Lys Arg Leu Gln Asn Asp Ala Glu His Leu Ser Asp 
            20                  25                  30          


Ile Gly Ile Thr Ala Val Trp Ile Pro Pro Ala Tyr Lys Gly Leu Ser 
        35                  40                  45              


Gln Ser Asp Asn Gly Tyr Gly Pro Tyr Asp Leu Tyr Asp Leu Gly Glu 
    50                  55                  60                  


Phe Gln Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly Thr Lys Ser Glu 
65                  70                  75                  80  


Leu Gln Asp Ala Ile Gly Ser Leu His Ser Arg Asn Val Gln Val Tyr 
                85                  90                  95      


Gly Asp Val Val Leu Asn His Lys Ala Gly Ala Asp Ser Thr Glu Trp 
            100                 105                 110         


Val Asp Ala Val Glu Val Asn Pro Ser Asn Arg Asn Gln Glu Thr Ser 
        115                 120                 125             


Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp Phe Pro Gly Arg 
    130                 135                 140                 


Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr His Phe Asp Gly 
145                 150                 155                 160 


Thr Asp Trp Asp Glu Ser Arg Lys Leu Asn Arg Ile Tyr Lys Phe Arg 
                165                 170                 175     


Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Asp Thr Glu Asn Gly Asn 
            180                 185                 190         


Tyr Asp Tyr Leu Met Phe Ala Asp Leu Asp Tyr Asp His Pro Asp Val 
        195                 200                 205             


Val Ala Glu Thr Lys Lys Trp Gly Ile Trp Tyr Ala Asn Glu Leu Ser 
    210                 215                 220                 


Leu Asp Gly Phe Arg Ile Asp Ala Ala Lys His Ile Lys Phe Ser Phe 
225                 230                 235                 240 


Leu Arg Asp Trp Val Gln Ala Val Arg Gln Ala Thr Gly Lys Glu Met 
                245                 250                 255     


Phe Thr Val Ala Glu Tyr Trp Gln Asn Asn Ala Gly Lys Leu Glu Asn 
            260                 265                 270         


Tyr Leu Asn Lys Thr Ser Phe Asn Gln Ser Val Phe Asp Val Pro Leu 
        275                 280                 285             


His Phe Asn Leu Gln Ala Ala Ser Ser Gln Gly Gly Gly Tyr Asp Met 
    290                 295                 300                 


Arg Arg Leu Leu Asp Gly Thr Val Val Ser Arg His Pro Glu Lys Ala 
305                 310                 315                 320 


Val Thr Phe Val Glu Asn His Asp Thr Gln Pro Gly Gln Ser Leu Glu 
                325                 330                 335     


Ser Thr Val Gln Thr Trp Phe Lys Pro Leu Ala Tyr Ala Phe Ile Leu 
            340                 345                 350         


Thr Arg Glu Ser Gly Tyr Pro Gln Val Phe Tyr Gly Asp Met Tyr Gly 
        355                 360                 365             


Thr Lys Gly Thr Ser Pro Lys Glu Ile Pro Ser Leu Lys Asp Asn Ile 
    370                 375                 380                 


Glu Pro Ile Leu Lys Ala Arg Lys Glu Tyr Ala Tyr Gly Pro Gln His 
385                 390                 395                 400 


Asp Tyr Ile Asp His Pro Asp Val Ile Gly Trp Thr Arg Glu Gly Asp 
                405                 410                 415     


Ser Ser Ala Ala Lys Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly Pro 
            420                 425                 430         


Gly Gly Ser Lys Arg Met Tyr Ala Gly Leu Lys Asn Ala Gly Glu Thr 
        435                 440                 445             


Trp Tyr Asp Ile Thr Gly Asn Arg Ser Asp Thr Val Lys Ile Gly Ser 
    450                 455                 460                 


Asp Gly Trp Gly Glu Phe His Val Asn Asp Gly Ser Val Ser Ile Tyr 
465                 470                 475                 480 


Val Gln Lys 
            


<210>  109
<211>  484
<212>  PRT
<213>  Artifical Sequence

<400>  109

Val Asn Gly Thr Leu Met Gln Tyr Phe Glu Trp Tyr Thr Pro Asn Asp 
1               5                   10                  15      


Gly Gln His Trp Lys Arg Leu Gln Asn Asp Ala Glu His Leu Ser Asp 
            20                  25                  30          


Ile Gly Ile Thr Ala Val Trp Ile Pro Pro Ala Tyr Lys Gly Leu Ser 
        35                  40                  45              


Gln Ser Asp Asn Gly Tyr Gly Pro Tyr Asp Leu Tyr Asp Leu Gly Glu 
    50                  55                  60                  


Phe Gln Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly Thr Lys Ser Glu 
65                  70                  75                  80  


Leu Gln Asp Ala Ile Gly Ser Leu His Ser Arg Asn Val Gln Val Tyr 
                85                  90                  95      


Gly Asp Val Val Leu Asn His Lys Gly Gly Ala Asp Phe Thr Glu Arg 
            100                 105                 110         


Val Gln Ala Val Glu Val Asn Pro Gln Asn Arg Asn Gln Glu Val Ser 
        115                 120                 125             


Gly Thr Tyr Gln Ile Glu Ala Trp Thr Gly Phe Asn Phe Pro Gly Arg 
    130                 135                 140                 


Gly Asn Gln His Ser Ser Phe Lys Trp Arg Trp Tyr His Phe Asp Gly 
145                 150                 155                 160 


Thr Asp Trp Asp Gln Ser Arg Gln Leu Ala Asn Arg Ile Tyr Lys Phe 
                165                 170                 175     


Arg Gly Asp Gly Lys Ala Trp Asp Trp Glu Val Asp Thr Glu Asn Gly 
            180                 185                 190         


Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Val Asp Tyr Asp His Pro Asp 
        195                 200                 205             


Val Val Ala Glu Thr Lys Lys Trp Gly Ile Trp Tyr Ala Asn Glu Leu 
    210                 215                 220                 


Ser Leu Asp Gly Phe Arg Ile Asp Ala Ala Lys His Ile Lys Phe Ser 
225                 230                 235                 240 


Phe Leu Arg Asp Trp Val Gln Ala Val Arg Gln Ala Thr Gly Lys Glu 
                245                 250                 255     


Met Phe Thr Val Ala Glu Tyr Trp Gln Asn Asn Ala Gly Lys Leu Glu 
            260                 265                 270         


Asn Tyr Leu Asn Lys Thr Ser Phe Asn Gln Ser Val Phe Asp Val Pro 
        275                 280                 285             


Leu His Phe Asn Leu Gln Ala Ala Ser Ser Gln Gly Gly Gly Tyr Asp 
    290                 295                 300                 


Met Arg Arg Leu Leu Asp Gly Thr Val Val Ser Arg His Pro Glu Lys 
305                 310                 315                 320 


Ala Val Thr Phe Val Glu Asn His Asp Thr Gln Pro Gly Gln Ser Leu 
                325                 330                 335     


Glu Ser Thr Val Gln Thr Trp Phe Lys Pro Leu Ala Tyr Ala Phe Ile 
            340                 345                 350         


Leu Thr Arg Glu Ser Gly Tyr Pro Gln Val Phe Tyr Gly Asp Met Tyr 
        355                 360                 365             


Gly Thr Lys Gly Thr Ser Pro Lys Glu Ile Pro Ser Leu Lys Asp Asn 
    370                 375                 380                 


Ile Glu Pro Ile Leu Lys Ala Arg Lys Glu Tyr Ala Tyr Gly Pro Gln 
385                 390                 395                 400 


His Asp Tyr Ile Asp His Pro Asp Val Ile Gly Trp Thr Arg Glu Gly 
                405                 410                 415     


Asp Ser Ser Ala Ala Lys Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly 
            420                 425                 430         


Pro Gly Gly Ser Lys Arg Met Tyr Ala Gly Leu Lys Asn Ala Gly Glu 
        435                 440                 445             


Thr Trp Tyr Asp Ile Thr Gly Asn Arg Ser Asp Thr Val Lys Ile Gly 
    450                 455                 460                 


Ser Asp Gly Trp Gly Glu Phe His Val Asn Asp Gly Ser Val Ser Ile 
465                 470                 475                 480 


Tyr Val Gln Lys 
                


<210>  110
<211>  484
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  110

Val Asn Gly Thr Leu Met Gln Tyr Phe Glu Trp Tyr Thr Pro Asn Asp 
1               5                   10                  15      


Gly Gln His Trp Lys Arg Leu Gln Asn Asp Ala Glu His Leu Ser Asp 
            20                  25                  30          


Ile Gly Ile Thr Ala Val Trp Ile Pro Pro Ala Tyr Lys Gly Leu Ser 
        35                  40                  45              


Gln Ser Asp Asn Gly Tyr Gly Pro Tyr Asp Leu Tyr Asp Leu Gly Glu 
    50                  55                  60                  


Phe Gln Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly Thr Lys Ser Glu 
65                  70                  75                  80  


Leu Gln Asp Ala Ile Gly Ser Leu His Ser Arg Asn Val Gln Val Tyr 
                85                  90                  95      


Gly Asp Val Val Leu Asn His Lys Gly Gly Ala Asp Ala Thr Glu Asn 
            100                 105                 110         


Val Leu Ala Val Glu Val Asn Pro Asn Asn Arg Asn Gln Glu Ile Ser 
        115                 120                 125             


Gly Asp Tyr Thr Ile Glu Ala Trp Thr Lys Phe Asp Phe Pro Gly Arg 
    130                 135                 140                 


Gly Asn Thr Tyr Ser Asp Phe Lys Trp Arg Trp Tyr His Phe Asp Gly 
145                 150                 155                 160 


Val Asp Trp Asp Gln Ser Arg Gln Phe Gln Asn Arg Ile Tyr Lys Phe 
                165                 170                 175     


Arg Gly Asp Gly Lys Ala Trp Asp Trp Glu Val Asp Ser Glu Asn Gly 
            180                 185                 190         


Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Val Asp Tyr Asp His Pro Asp 
        195                 200                 205             


Val Val Ala Glu Thr Lys Lys Trp Gly Ile Trp Tyr Ala Asn Glu Leu 
    210                 215                 220                 


Ser Leu Asp Gly Phe Arg Ile Asp Ala Ala Lys His Ile Lys Phe Ser 
225                 230                 235                 240 


Phe Leu Arg Asp Trp Val Gln Ala Val Arg Gln Ala Thr Gly Lys Glu 
                245                 250                 255     


Met Phe Thr Val Ala Glu Tyr Trp Gln Asn Asn Ala Gly Lys Leu Glu 
            260                 265                 270         


Asn Tyr Leu Asn Lys Thr Ser Phe Asn Gln Ser Val Phe Asp Val Pro 
        275                 280                 285             


Leu His Phe Asn Leu Gln Ala Ala Ser Ser Gln Gly Gly Gly Tyr Asp 
    290                 295                 300                 


Met Arg Arg Leu Leu Asp Gly Thr Val Val Ser Arg His Pro Glu Lys 
305                 310                 315                 320 


Ala Val Thr Phe Val Glu Asn His Asp Thr Gln Pro Gly Gln Ser Leu 
                325                 330                 335     


Glu Ser Thr Val Gln Thr Trp Phe Lys Pro Leu Ala Tyr Ala Phe Ile 
            340                 345                 350         


Leu Thr Arg Glu Ser Gly Tyr Pro Gln Val Phe Tyr Gly Asp Met Tyr 
        355                 360                 365             


Gly Thr Lys Gly Thr Ser Pro Lys Glu Ile Pro Ser Leu Lys Asp Asn 
    370                 375                 380                 


Ile Glu Pro Ile Leu Lys Ala Arg Lys Glu Tyr Ala Tyr Gly Pro Gln 
385                 390                 395                 400 


His Asp Tyr Ile Asp His Pro Asp Val Ile Gly Trp Thr Arg Glu Gly 
                405                 410                 415     


Asp Ser Ser Ala Ala Lys Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly 
            420                 425                 430         


Pro Gly Gly Ser Lys Arg Met Tyr Ala Gly Leu Lys Asn Ala Gly Glu 
        435                 440                 445             


Thr Trp Tyr Asp Ile Thr Gly Asn Arg Ser Asp Thr Val Lys Ile Gly 
    450                 455                 460                 


Ser Asp Gly Trp Gly Glu Phe His Val Asn Asp Gly Ser Val Ser Ile 
465                 470                 475                 480 


Tyr Val Gln Lys 
                


<210>  111
<211>  484
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  111

Val Asn Gly Thr Leu Met Gln Tyr Phe Glu Trp Tyr Thr Pro Asn Asp 
1               5                   10                  15      


Gly Gln His Trp Lys Arg Leu Gln Asn Asp Ala Glu His Leu Ser Asp 
            20                  25                  30          


Ile Gly Ile Thr Ala Val Trp Ile Pro Pro Ala Tyr Lys Gly Leu Ser 
        35                  40                  45              


Gln Ser Asp Asn Gly Tyr Gly Pro Tyr Asp Leu Tyr Asp Leu Gly Glu 
    50                  55                  60                  


Phe Gln Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly Thr Lys Ser Glu 
65                  70                  75                  80  


Leu Gln Asp Ala Ile Gly Ser Leu His Ser Arg Asn Val Gln Val Tyr 
                85                  90                  95      


Gly Asp Val Val Leu Asn His Lys Gly Gly Ala Asp Ala Thr Glu Met 
            100                 105                 110         


Val Arg Ala Val Glu Val Asn Pro Asn Asn Arg Asn Gln Glu Val Ser 
        115                 120                 125             


Gly Glu Tyr Thr Ile Glu Ala Trp Thr Lys Phe Asp Phe Pro Gly Arg 
    130                 135                 140                 


Gly Asn Thr His Ser Asn Phe Lys Trp Arg Trp Tyr His Phe Asp Gly 
145                 150                 155                 160 


Val Asp Trp Asp Gln Ser Arg Lys Leu Asn Asn Arg Ile Tyr Lys Phe 
                165                 170                 175     


Arg Gly Asp Gly Lys Gly Trp Asp Trp Glu Val Asp Thr Glu Asn Gly 
            180                 185                 190         


Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Ile Asp Tyr Asp His Pro Asp 
        195                 200                 205             


Val Val Ala Glu Thr Lys Lys Trp Gly Ile Trp Tyr Ala Asn Glu Leu 
    210                 215                 220                 


Ser Leu Asp Gly Phe Arg Ile Asp Ala Ala Lys His Ile Lys Phe Ser 
225                 230                 235                 240 


Phe Leu Arg Asp Trp Val Gln Ala Val Arg Gln Ala Thr Gly Lys Glu 
                245                 250                 255     


Met Phe Thr Val Ala Glu Tyr Trp Gln Asn Asn Ala Gly Lys Leu Glu 
            260                 265                 270         


Asn Tyr Leu Asn Lys Thr Ser Phe Asn Gln Ser Val Phe Asp Val Pro 
        275                 280                 285             


Leu His Phe Asn Leu Gln Ala Ala Ser Ser Gln Gly Gly Gly Tyr Asp 
    290                 295                 300                 


Met Arg Arg Leu Leu Asp Gly Thr Val Val Ser Arg His Pro Glu Lys 
305                 310                 315                 320 


Ala Val Thr Phe Val Glu Asn His Asp Thr Gln Pro Gly Gln Ser Leu 
                325                 330                 335     


Glu Ser Thr Val Gln Thr Trp Phe Lys Pro Leu Ala Tyr Ala Phe Ile 
            340                 345                 350         


Leu Thr Arg Glu Ser Gly Tyr Pro Gln Val Phe Tyr Gly Asp Met Tyr 
        355                 360                 365             


Gly Thr Lys Gly Thr Ser Pro Lys Glu Ile Pro Ser Leu Lys Asp Asn 
    370                 375                 380                 


Ile Glu Pro Ile Leu Lys Ala Arg Lys Glu Tyr Ala Tyr Gly Pro Gln 
385                 390                 395                 400 


His Asp Tyr Ile Asp His Pro Asp Val Ile Gly Trp Thr Arg Glu Gly 
                405                 410                 415     


Asp Ser Ser Ala Ala Lys Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly 
            420                 425                 430         


Pro Gly Gly Ser Lys Arg Met Tyr Ala Gly Leu Lys Asn Ala Gly Glu 
        435                 440                 445             


Thr Trp Tyr Asp Ile Thr Gly Asn Arg Ser Asp Thr Val Lys Ile Gly 
    450                 455                 460                 


Ser Asp Gly Trp Gly Glu Phe His Val Asn Asp Gly Ser Val Ser Ile 
465                 470                 475                 480 


Tyr Val Gln Lys 
                


<210>  112
<211>  484
<212>  PRT
<213>  Artifical Sequence

<400>  112

Val Asn Gly Thr Leu Met Gln Tyr Phe Glu Trp Tyr Thr Pro Asn Asp 
1               5                   10                  15      


Gly Gln His Trp Lys Arg Leu Gln Asn Asp Ala Glu His Leu Ser Asp 
            20                  25                  30          


Ile Gly Ile Thr Ala Val Trp Ile Pro Pro Ala Tyr Lys Gly Leu Ser 
        35                  40                  45              


Gln Ser Asp Asn Gly Tyr Gly Pro Tyr Asp Leu Tyr Asp Leu Gly Glu 
    50                  55                  60                  


Phe Gln Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly Thr Lys Ser Glu 
65                  70                  75                  80  


Leu Gln Asp Ala Ile Gly Ser Leu His Ser Arg Asn Val Gln Val Tyr 
                85                  90                  95      


Gly Asp Val Val Leu Asn His Lys Gly Gly Ala Asp Ala Thr Glu Met 
            100                 105                 110         


Val Arg Ala Val Glu Val Asn Pro Asn Asn Arg Asn Gln Glu Val Thr 
        115                 120                 125             


Gly Glu Tyr Thr Ile Glu Ala Trp Thr Arg Phe Asp Phe Pro Gly Arg 
    130                 135                 140                 


Gly Asn Thr His Ser Ser Phe Lys Trp Arg Trp Tyr His Phe Asp Gly 
145                 150                 155                 160 


Val Asp Trp Asp Gln Ser Arg Arg Leu Asn Asn Arg Ile Tyr Lys Phe 
                165                 170                 175     


Arg Gly His Gly Lys Ala Trp Asp Trp Glu Val Asp Thr Glu Asn Gly 
            180                 185                 190         


Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Ile Asp Tyr Asp His Pro Asp 
        195                 200                 205             


Val Val Ala Glu Thr Lys Lys Trp Gly Ile Trp Tyr Ala Asn Glu Leu 
    210                 215                 220                 


Ser Leu Asp Gly Phe Arg Ile Asp Ala Ala Lys His Ile Lys Phe Ser 
225                 230                 235                 240 


Phe Leu Arg Asp Trp Val Gln Ala Val Arg Gln Ala Thr Gly Lys Glu 
                245                 250                 255     


Met Phe Thr Val Ala Glu Tyr Trp Gln Asn Asn Ala Gly Lys Leu Glu 
            260                 265                 270         


Asn Tyr Leu Asn Lys Thr Ser Phe Asn Gln Ser Val Phe Asp Val Pro 
        275                 280                 285             


Leu His Phe Asn Leu Gln Ala Ala Ser Ser Gln Gly Gly Gly Tyr Asp 
    290                 295                 300                 


Met Arg Arg Leu Leu Asp Gly Thr Val Val Ser Arg His Pro Glu Lys 
305                 310                 315                 320 


Ala Val Thr Phe Val Glu Asn His Asp Thr Gln Pro Gly Gln Ser Leu 
                325                 330                 335     


Glu Ser Thr Val Gln Thr Trp Phe Lys Pro Leu Ala Tyr Ala Phe Ile 
            340                 345                 350         


Leu Thr Arg Glu Ser Gly Tyr Pro Gln Val Phe Tyr Gly Asp Met Tyr 
        355                 360                 365             


Gly Thr Lys Gly Thr Ser Pro Lys Glu Ile Pro Ser Leu Lys Asp Asn 
    370                 375                 380                 


Ile Glu Pro Ile Leu Lys Ala Arg Lys Glu Tyr Ala Tyr Gly Pro Gln 
385                 390                 395                 400 


His Asp Tyr Ile Asp His Pro Asp Val Ile Gly Trp Thr Arg Glu Gly 
                405                 410                 415     


Asp Ser Ser Ala Ala Lys Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly 
            420                 425                 430         


Pro Gly Gly Ser Lys Arg Met Tyr Ala Gly Leu Lys Asn Ala Gly Glu 
        435                 440                 445             


Thr Trp Tyr Asp Ile Thr Gly Asn Arg Ser Asp Thr Val Lys Ile Gly 
    450                 455                 460                 


Ser Asp Gly Trp Gly Glu Phe His Val Asn Asp Gly Ser Val Ser Ile 
465                 470                 475                 480 


Tyr Val Gln Lys 
                


<210>  113
<211>  486
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  113

Ala Asn Leu Asn Gly Thr Leu Met Gln Tyr Phe Glu Trp Tyr Met Pro 
1               5                   10                  15      


Asn Asp Gly Gln His Trp Lys Arg Leu Gln Asn Asp Ser Ala Tyr Leu 
            20                  25                  30          


Ala Glu His Gly Ile Thr Ala Val Trp Ile Pro Pro Ala Tyr Lys Gly 
        35                  40                  45              


Thr Ser Gln Ala Asp Val Gly Tyr Gly Ala Tyr Asp Leu Tyr Asp Leu 
    50                  55                  60                  


Gly Glu Phe His Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly Thr Lys 
65                  70                  75                  80  


Gly Glu Leu Gln Ser Ala Ile Lys Ser Leu His Ser Arg Asp Ile Asn 
                85                  90                  95      


Val Tyr Gly Asp Val Val Ile Asn His Arg Met Gly Ala Asp Ala Thr 
            100                 105                 110         


Glu Thr Ile Ser Ala Val Glu Val Asn Pro Ser Asn Arg Asn Gln Val 
        115                 120                 125             


Thr Ser Gly Ala Tyr Asn Ile Ser Ala Trp Thr Asp Phe Glu Phe Pro 
    130                 135                 140                 


Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp His Ser Tyr Tyr Phe 
145                 150                 155                 160 


Asp Gly Val Asp Trp Asp Gln Ser Arg Gln Leu Ser Gly Lys Ile Tyr 
                165                 170                 175     


Gln Ile Gln Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Asp Ser Glu 
            180                 185                 190         


Asn Gly Asn Tyr Asp Tyr Leu Met Gly Ala Asp Ile Asp Tyr Asp His 
        195                 200                 205             


Pro Asp Val Ala Ala Glu Ile Lys Arg Trp Gly Thr Trp Tyr Ala Asn 
    210                 215                 220                 


Glu Leu Gln Leu Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile Lys 
225                 230                 235                 240 


Phe Ser Phe Leu Arg Asp Trp Val Asn His Val Arg Glu Lys Thr Gly 
                245                 250                 255     


Lys Glu Met Phe Thr Val Ala Glu Tyr Trp Ser Tyr Asp Leu Gly Ala 
            260                 265                 270         


Leu Glu Asn Tyr Leu Asn Lys Thr Asn Phe Asn His Ser Val Phe Asp 
        275                 280                 285             


Val Pro Leu His Tyr Gln Phe His Ala Ala Ser Thr Gln Gly Gly Gly 
    290                 295                 300                 


Tyr Asp Met Arg Lys Leu Leu Asn Gly Thr Val Val Ser Lys His Pro 
305                 310                 315                 320 


Leu Lys Ser Val Thr Phe Val Asp Asn His Asp Thr Gln Pro Gly Gln 
                325                 330                 335     


Ser Leu Glu Ser Thr Val Gln Thr Trp Phe Lys Pro Leu Ala Tyr Ala 
            340                 345                 350         


Phe Ile Leu Thr Arg Glu Ser Gly Tyr Pro Gln Val Phe Tyr Gly Asp 
        355                 360                 365             


Met Tyr Gly Thr Lys Gly Asp Ser Gln Arg Glu Ile Pro Ala Leu Lys 
    370                 375                 380                 


His Lys Ile Glu Pro Ile Leu Lys Ala Arg Lys Gln Tyr Ala Tyr Gly 
385                 390                 395                 400 


Ala Gln His Asp Tyr Phe Asp His His Asp Ile Val Gly Trp Thr Arg 
                405                 410                 415     


Glu Gly Asp Ser Ser Val Ala Asn Ser Gly Leu Ala Ala Leu Ile Thr 
            420                 425                 430         


Asp Gly Pro Gly Gly Ala Lys Arg Met Tyr Val Gly Arg Gln Asn Ala 
        435                 440                 445             


Gly Glu Thr Trp His Asp Ile Thr Gly Asn Arg Ser Glu Pro Val Val 
    450                 455                 460                 


Ile Asn Ser Ala Gly Trp Gly Glu Phe His Val Asn Gly Gly Ser Val 
465                 470                 475                 480 


Ser Ile Tyr Val Gln Arg 
                485     


<210>  114
<211>  485
<212>  PRT
<213>  Artifiical Sequence

<400>  114

Ala Asn Leu Asn Gly Thr Leu Met Gln Tyr Phe Glu Trp Tyr Met Pro 
1               5                   10                  15      


Asn Asp Gly Gln His Trp Lys Arg Leu Gln Asn Asp Ser Ala Tyr Leu 
            20                  25                  30          


Ala Glu His Gly Ile Thr Ala Val Trp Ile Pro Pro Ala Tyr Lys Gly 
        35                  40                  45              


Thr Ser Gln Ala Asp Val Gly Tyr Gly Ala Tyr Asp Leu Tyr Asp Leu 
    50                  55                  60                  


Gly Glu Phe His Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly Thr Lys 
65                  70                  75                  80  


Gly Glu Leu Gln Ser Ala Ile Lys Ser Leu His Ser Arg Asp Ile Asn 
                85                  90                  95      


Val Tyr Gly Asp Val Val Ile Asn His Lys Ala Gly Ala Asp Ala Thr 
            100                 105                 110         


Glu Asp Val Thr Ala Val Glu Val Asn Pro Ala Asn Arg Asn Gln Glu 
        115                 120                 125             


Thr Ser Glu Glu Tyr Gln Ile Lys Ala Trp Thr Asp Phe Arg Phe Pro 
    130                 135                 140                 


Gly Arg Gly Asn Thr Tyr Ser Asp Phe Lys Trp His Trp Tyr His Phe 
145                 150                 155                 160 


Asp Gly Ala Asp Trp Asp Glu Ser Arg Lys Ile Ser Arg Ile Phe Lys 
                165                 170                 175     


Phe Arg Gly Glu Gly Lys Ala Trp Asp Trp Glu Val Ser Ser Glu Asn 
            180                 185                 190         


Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Val Asp Tyr Asp His Pro 
        195                 200                 205             


Asp Val Ala Ala Glu Ile Lys Arg Trp Gly Thr Trp Tyr Ala Asn Glu 
    210                 215                 220                 


Leu Gln Leu Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile Lys Phe 
225                 230                 235                 240 


Ser Phe Leu Arg Asp Trp Val Asn His Val Arg Glu Lys Thr Gly Lys 
                245                 250                 255     


Glu Met Phe Thr Val Ala Glu Tyr Trp Ser Tyr Asp Leu Gly Ala Leu 
            260                 265                 270         


Glu Asn Tyr Leu Asn Lys Thr Asn Phe Asn His Ser Val Phe Asp Val 
        275                 280                 285             


Pro Leu His Tyr Gln Phe His Ala Ala Ser Thr Gln Gly Gly Gly Tyr 
    290                 295                 300                 


Asp Met Arg Lys Leu Leu Asn Gly Thr Val Val Ser Lys His Pro Leu 
305                 310                 315                 320 


Lys Ser Val Thr Phe Val Asp Asn His Asp Thr Gln Pro Gly Gln Ser 
                325                 330                 335     


Leu Glu Ser Thr Val Gln Thr Trp Phe Lys Pro Leu Ala Tyr Ala Phe 
            340                 345                 350         


Ile Leu Thr Arg Glu Ser Gly Tyr Pro Gln Val Phe Tyr Gly Asp Met 
        355                 360                 365             


Tyr Gly Thr Lys Gly Asp Ser Gln Arg Glu Ile Pro Ala Leu Lys His 
    370                 375                 380                 


Lys Ile Glu Pro Ile Leu Lys Ala Arg Lys Gln Tyr Ala Tyr Gly Ala 
385                 390                 395                 400 


Gln His Asp Tyr Phe Asp His His Asp Ile Val Gly Trp Thr Arg Glu 
                405                 410                 415     


Gly Asp Ser Ser Val Ala Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp 
            420                 425                 430         


Gly Pro Gly Gly Ala Lys Arg Met Tyr Val Gly Arg Gln Asn Ala Gly 
        435                 440                 445             


Glu Thr Trp His Asp Ile Thr Gly Asn Arg Ser Glu Pro Val Val Ile 
    450                 455                 460                 


Asn Ser Ala Gly Trp Gly Glu Phe His Val Asn Gly Gly Ser Val Ser 
465                 470                 475                 480 


Ile Tyr Val Gln Arg 
                485 


<210>  115
<211>  485
<212>  PRT
<213>  Artifiical Sequence

<400>  115

Ala Asn Leu Asn Gly Thr Leu Met Gln Tyr Phe Glu Trp Tyr Met Pro 
1               5                   10                  15      


Asn Asp Gly Gln His Trp Lys Arg Leu Gln Asn Asp Ser Ala Tyr Leu 
            20                  25                  30          


Ala Glu His Gly Ile Thr Ala Val Trp Ile Pro Pro Ala Tyr Lys Gly 
        35                  40                  45              


Thr Ser Gln Ala Asp Val Gly Tyr Gly Ala Tyr Asp Leu Tyr Asp Leu 
    50                  55                  60                  


Gly Glu Phe His Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly Thr Lys 
65                  70                  75                  80  


Gly Glu Leu Gln Ser Ala Ile Lys Ser Leu His Ser Arg Asp Ile Asn 
                85                  90                  95      


Val Tyr Gly Asp Val Val Ile Asn His Lys Ala Gly Ala Asp Tyr Thr 
            100                 105                 110         


Glu Asn Val Thr Ala Val Glu Val Asn Pro Ser Asn Arg Asn Gln Glu 
        115                 120                 125             


Thr Ser Gly Glu Tyr Asn Ile Gln Ala Trp Thr Gly Phe Asn Phe Pro 
    130                 135                 140                 


Gly Arg Gly Thr Thr Tyr Ser Asn Phe Lys Trp Gln Trp Phe His Phe 
145                 150                 155                 160 


Asp Gly Thr Asp Trp Asp Gln Ser Arg Ser Leu Ser Arg Ile Phe Lys 
                165                 170                 175     


Phe Arg Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Ser Ser Glu Asn 
            180                 185                 190         


Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Ile Asp Tyr Asp His Pro 
        195                 200                 205             


Asp Val Ala Ala Glu Ile Lys Arg Trp Gly Thr Trp Tyr Ala Asn Glu 
    210                 215                 220                 


Leu Gln Leu Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile Lys Phe 
225                 230                 235                 240 


Ser Phe Leu Arg Asp Trp Val Asn His Val Arg Glu Lys Thr Gly Lys 
                245                 250                 255     


Glu Met Phe Thr Val Ala Glu Tyr Trp Ser Tyr Asp Leu Gly Ala Leu 
            260                 265                 270         


Glu Asn Tyr Leu Asn Lys Thr Asn Phe Asn His Ser Val Phe Asp Val 
        275                 280                 285             


Pro Leu His Tyr Gln Phe His Ala Ala Ser Thr Gln Gly Gly Gly Tyr 
    290                 295                 300                 


Asp Met Arg Lys Leu Leu Asn Gly Thr Val Val Ser Lys His Pro Leu 
305                 310                 315                 320 


Lys Ser Val Thr Phe Val Asp Asn His Asp Thr Gln Pro Gly Gln Ser 
                325                 330                 335     


Leu Glu Ser Thr Val Gln Thr Trp Phe Lys Pro Leu Ala Tyr Ala Phe 
            340                 345                 350         


Ile Leu Thr Arg Glu Ser Gly Tyr Pro Gln Val Phe Tyr Gly Asp Met 
        355                 360                 365             


Tyr Gly Thr Lys Gly Asp Ser Gln Arg Glu Ile Pro Ala Leu Lys His 
    370                 375                 380                 


Lys Ile Glu Pro Ile Leu Lys Ala Arg Lys Gln Tyr Ala Tyr Gly Ala 
385                 390                 395                 400 


Gln His Asp Tyr Phe Asp His His Asp Ile Val Gly Trp Thr Arg Glu 
                405                 410                 415     


Gly Asp Ser Ser Val Ala Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp 
            420                 425                 430         


Gly Pro Gly Gly Ala Lys Arg Met Tyr Val Gly Arg Gln Asn Ala Gly 
        435                 440                 445             


Glu Thr Trp His Asp Ile Thr Gly Asn Arg Ser Glu Pro Val Val Ile 
    450                 455                 460                 


Asn Ser Ala Gly Trp Gly Glu Phe His Val Asn Gly Gly Ser Val Ser 
465                 470                 475                 480 


Ile Tyr Val Gln Arg 
                485 


<210>  116
<211>  485
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  116

Ala Asn Leu Asn Gly Thr Leu Met Gln Tyr Phe Glu Trp Tyr Met Pro 
1               5                   10                  15      


Asn Asp Gly Gln His Trp Lys Arg Leu Gln Asn Asp Ser Ala Tyr Leu 
            20                  25                  30          


Ala Glu His Gly Ile Thr Ala Val Trp Ile Pro Pro Ala Tyr Lys Gly 
        35                  40                  45              


Thr Ser Gln Ala Asp Val Gly Tyr Gly Ala Tyr Asp Leu Tyr Asp Leu 
    50                  55                  60                  


Gly Glu Phe His Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly Thr Lys 
65                  70                  75                  80  


Gly Glu Leu Gln Ser Ala Ile Lys Ser Leu His Ser Arg Asp Ile Asn 
                85                  90                  95      


Val Tyr Gly Asp Val Val Ile Asp His Lys Gly Gly Ala Asp Gly Thr 
            100                 105                 110         


Glu Trp Val Asp Ala Val Glu Val Asn Pro Ser Asp Arg Asn Gln Glu 
        115                 120                 125             


Ile Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp Phe Pro 
    130                 135                 140                 


Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr His Phe 
145                 150                 155                 160 


Asp Gly Val Asp Trp Asp Glu Ser Arg Lys Leu Ser Arg Ile Tyr Lys 
                165                 170                 175     


Phe Arg Gly Ile Gly Lys Ala Trp Asp Trp Glu Val Asp Thr Glu Asn 
            180                 185                 190         


Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Leu Asp Tyr Asp His Pro 
        195                 200                 205             


Asp Val Ala Ala Glu Ile Lys Arg Trp Gly Thr Trp Tyr Ala Asn Glu 
    210                 215                 220                 


Leu Gln Leu Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile Lys Phe 
225                 230                 235                 240 


Ser Phe Leu Arg Asp Trp Val Asn His Val Arg Glu Lys Thr Gly Lys 
                245                 250                 255     


Glu Met Phe Thr Val Ala Glu Tyr Trp Ser Tyr Asp Leu Gly Ala Leu 
            260                 265                 270         


Glu Asn Tyr Leu Asn Lys Thr Asn Phe Asn His Ser Val Phe Asp Val 
        275                 280                 285             


Pro Leu His Tyr Gln Phe His Ala Ala Ser Thr Gln Gly Gly Gly Tyr 
    290                 295                 300                 


Asp Met Arg Lys Leu Leu Asn Gly Thr Val Val Ser Lys His Pro Leu 
305                 310                 315                 320 


Lys Ser Val Thr Phe Val Asp Asn His Asp Thr Gln Pro Gly Gln Ser 
                325                 330                 335     


Leu Glu Ser Thr Val Gln Thr Trp Phe Lys Pro Leu Ala Tyr Ala Phe 
            340                 345                 350         


Ile Leu Thr Arg Glu Ser Gly Tyr Pro Gln Val Phe Tyr Gly Asp Met 
        355                 360                 365             


Tyr Gly Thr Lys Gly Asp Ser Gln Arg Glu Ile Pro Ala Leu Lys His 
    370                 375                 380                 


Lys Ile Glu Pro Ile Leu Lys Ala Arg Lys Gln Tyr Ala Tyr Gly Ala 
385                 390                 395                 400 


Gln His Asp Tyr Phe Asp His His Asp Ile Val Gly Trp Thr Arg Glu 
                405                 410                 415     


Gly Asp Ser Ser Val Ala Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp 
            420                 425                 430         


Gly Pro Gly Gly Ala Lys Arg Met Tyr Val Gly Arg Gln Asn Ala Gly 
        435                 440                 445             


Glu Thr Trp His Asp Ile Thr Gly Asn Arg Ser Glu Pro Val Val Ile 
    450                 455                 460                 


Asn Ser Ala Gly Trp Gly Glu Phe His Val Asn Gly Gly Ser Val Ser 
465                 470                 475                 480 


Ile Tyr Val Gln Arg 
                485 


<210>  117
<211>  485
<212>  PRT
<213>  Artifical Sequence

<400>  117

Ala Asn Leu Asn Gly Thr Leu Met Gln Tyr Phe Glu Trp Tyr Met Pro 
1               5                   10                  15      


Asn Asp Gly Gln His Trp Lys Arg Leu Gln Asn Asp Ser Ala Tyr Leu 
            20                  25                  30          


Ala Glu His Gly Ile Thr Ala Val Trp Ile Pro Pro Ala Tyr Lys Gly 
        35                  40                  45              


Thr Ser Gln Ala Asp Val Gly Tyr Gly Ala Tyr Asp Leu Tyr Asp Leu 
    50                  55                  60                  


Gly Glu Phe His Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly Thr Lys 
65                  70                  75                  80  


Gly Glu Leu Gln Ser Ala Ile Lys Ser Leu His Ser Arg Asp Ile Asn 
                85                  90                  95      


Val Tyr Gly Asp Val Val Ile Asn His Lys Ala Gly Ala Asp Gly Thr 
            100                 105                 110         


Glu Leu Val Asp Ala Val Glu Val Asn Pro Ser Asp Arg Asn Gln Glu 
        115                 120                 125             


Ile Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp Phe Pro 
    130                 135                 140                 


Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr His Phe 
145                 150                 155                 160 


Asp Gly Thr Asp Trp Asp Glu Ser Arg Lys Leu Asn Arg Ile Tyr Lys 
                165                 170                 175     


Phe Arg Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Asp Thr Glu Asn 
            180                 185                 190         


Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Leu Asp Tyr Asp His Pro 
        195                 200                 205             


Asp Val Ala Ala Glu Ile Lys Arg Trp Gly Thr Trp Tyr Ala Asn Glu 
    210                 215                 220                 


Leu Gln Leu Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile Lys Phe 
225                 230                 235                 240 


Ser Phe Leu Arg Asp Trp Val Asn His Val Arg Glu Lys Thr Gly Lys 
                245                 250                 255     


Glu Met Phe Thr Val Ala Glu Tyr Trp Ser Tyr Asp Leu Gly Ala Leu 
            260                 265                 270         


Glu Asn Tyr Leu Asn Lys Thr Asn Phe Asn His Ser Val Phe Asp Val 
        275                 280                 285             


Pro Leu His Tyr Gln Phe His Ala Ala Ser Thr Gln Gly Gly Gly Tyr 
    290                 295                 300                 


Asp Met Arg Lys Leu Leu Asn Gly Thr Val Val Ser Lys His Pro Leu 
305                 310                 315                 320 


Lys Ser Val Thr Phe Val Asp Asn His Asp Thr Gln Pro Gly Gln Ser 
                325                 330                 335     


Leu Glu Ser Thr Val Gln Thr Trp Phe Lys Pro Leu Ala Tyr Ala Phe 
            340                 345                 350         


Ile Leu Thr Arg Glu Ser Gly Tyr Pro Gln Val Phe Tyr Gly Asp Met 
        355                 360                 365             


Tyr Gly Thr Lys Gly Asp Ser Gln Arg Glu Ile Pro Ala Leu Lys His 
    370                 375                 380                 


Lys Ile Glu Pro Ile Leu Lys Ala Arg Lys Gln Tyr Ala Tyr Gly Ala 
385                 390                 395                 400 


Gln His Asp Tyr Phe Asp His His Asp Ile Val Gly Trp Thr Arg Glu 
                405                 410                 415     


Gly Asp Ser Ser Val Ala Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp 
            420                 425                 430         


Gly Pro Gly Gly Ala Lys Arg Met Tyr Val Gly Arg Gln Asn Ala Gly 
        435                 440                 445             


Glu Thr Trp His Asp Ile Thr Gly Asn Arg Ser Glu Pro Val Val Ile 
    450                 455                 460                 


Asn Ser Ala Gly Trp Gly Glu Phe His Val Asn Gly Gly Ser Val Ser 
465                 470                 475                 480 


Ile Tyr Val Gln Arg 
                485 


<210>  118
<211>  485
<212>  PRT
<213>  Artifiical Sequence

<400>  118

Ala Asn Leu Asn Gly Thr Leu Met Gln Tyr Phe Glu Trp Tyr Met Pro 
1               5                   10                  15      


Asn Asp Gly Gln His Trp Lys Arg Leu Gln Asn Asp Ser Ala Tyr Leu 
            20                  25                  30          


Ala Glu His Gly Ile Thr Ala Val Trp Ile Pro Pro Ala Tyr Lys Gly 
        35                  40                  45              


Thr Ser Gln Ala Asp Val Gly Tyr Gly Ala Tyr Asp Leu Tyr Asp Leu 
    50                  55                  60                  


Gly Glu Phe His Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly Thr Lys 
65                  70                  75                  80  


Gly Glu Leu Gln Ser Ala Ile Lys Ser Leu His Ser Arg Asp Ile Asn 
                85                  90                  95      


Val Tyr Gly Asp Val Val Ile Asn His Lys Ala Gly Ala Asp Gly Thr 
            100                 105                 110         


Glu Phe Val Asp Ala Val Glu Val Asn Pro Ser Asn Arg Asn Gln Glu 
        115                 120                 125             


Thr Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp Phe Pro 
    130                 135                 140                 


Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr His Phe 
145                 150                 155                 160 


Asp Gly Thr Asp Trp Asp Glu Ser Arg Lys Leu Asn Arg Val Tyr Lys 
                165                 170                 175     


Phe Arg Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Asp Thr Glu Asn 
            180                 185                 190         


Gly Asn Tyr Asp Tyr Leu Met Phe Ala Asp Leu Asp Tyr Asp His Pro 
        195                 200                 205             


Asp Val Ala Ala Glu Ile Lys Arg Trp Gly Thr Trp Tyr Ala Asn Glu 
    210                 215                 220                 


Leu Gln Leu Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile Lys Phe 
225                 230                 235                 240 


Ser Phe Leu Arg Asp Trp Val Asn His Val Arg Glu Lys Thr Gly Lys 
                245                 250                 255     


Glu Met Phe Thr Val Ala Glu Tyr Trp Ser Tyr Asp Leu Gly Ala Leu 
            260                 265                 270         


Glu Asn Tyr Leu Asn Lys Thr Asn Phe Asn His Ser Val Phe Asp Val 
        275                 280                 285             


Pro Leu His Tyr Gln Phe His Ala Ala Ser Thr Gln Gly Gly Gly Tyr 
    290                 295                 300                 


Asp Met Arg Lys Leu Leu Asn Gly Thr Val Val Ser Lys His Pro Leu 
305                 310                 315                 320 


Lys Ser Val Thr Phe Val Asp Asn His Asp Thr Gln Pro Gly Gln Ser 
                325                 330                 335     


Leu Glu Ser Thr Val Gln Thr Trp Phe Lys Pro Leu Ala Tyr Ala Phe 
            340                 345                 350         


Ile Leu Thr Arg Glu Ser Gly Tyr Pro Gln Val Phe Tyr Gly Asp Met 
        355                 360                 365             


Tyr Gly Thr Lys Gly Asp Ser Gln Arg Glu Ile Pro Ala Leu Lys His 
    370                 375                 380                 


Lys Ile Glu Pro Ile Leu Lys Ala Arg Lys Gln Tyr Ala Tyr Gly Ala 
385                 390                 395                 400 


Gln His Asp Tyr Phe Asp His His Asp Ile Val Gly Trp Thr Arg Glu 
                405                 410                 415     


Gly Asp Ser Ser Val Ala Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp 
            420                 425                 430         


Gly Pro Gly Gly Ala Lys Arg Met Tyr Val Gly Arg Gln Asn Ala Gly 
        435                 440                 445             


Glu Thr Trp His Asp Ile Thr Gly Asn Arg Ser Glu Pro Val Val Ile 
    450                 455                 460                 


Asn Ser Ala Gly Trp Gly Glu Phe His Val Asn Gly Gly Ser Val Ser 
465                 470                 475                 480 


Ile Tyr Val Gln Arg 
                485 


<210>  119
<211>  484
<212>  PRT
<213>  Artifiical Sequence

<400>  119

Ala Asn Leu Asn Gly Thr Leu Met Gln Tyr Phe Glu Trp Tyr Met Pro 
1               5                   10                  15      


Asn Asp Gly Gln His Trp Lys Arg Leu Gln Asn Asp Ser Ala Tyr Leu 
            20                  25                  30          


Ala Glu His Gly Ile Thr Ala Val Trp Ile Pro Pro Ala Tyr Lys Gly 
        35                  40                  45              


Thr Ser Gln Ala Asp Val Gly Tyr Gly Ala Tyr Asp Leu Tyr Asp Leu 
    50                  55                  60                  


Gly Glu Phe His Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly Thr Lys 
65                  70                  75                  80  


Gly Glu Leu Gln Ser Ala Ile Lys Ser Leu His Ser Arg Asp Ile Asn 
                85                  90                  95      


Val Tyr Gly Asp Val Val Ile Asn His Lys Ala Gly Ala Asp Gly Thr 
            100                 105                 110         


Glu Phe Val Asp Ala Val Glu Val Asp Pro Ser Asn Arg Asn Gln Glu 
        115                 120                 125             


Thr Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp Phe Pro 
    130                 135                 140                 


Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr His Phe 
145                 150                 155                 160 


Asp Gly Thr Asp Trp Asp Glu Ser Arg Lys Leu Asn Arg Ile Tyr Lys 
                165                 170                 175     


Phe Ser Thr Gly Lys Ala Trp Asp Trp Glu Val Asp Thr Glu Asn Gly 
            180                 185                 190         


Asn Tyr Asp Tyr Leu Met Phe Ala Asp Leu Asp Tyr Asp His Pro Asp 
        195                 200                 205             


Val Ala Ala Glu Ile Lys Arg Trp Gly Thr Trp Tyr Ala Asn Glu Leu 
    210                 215                 220                 


Gln Leu Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile Lys Phe Ser 
225                 230                 235                 240 


Phe Leu Arg Asp Trp Val Asn His Val Arg Glu Lys Thr Gly Lys Glu 
                245                 250                 255     


Met Phe Thr Val Ala Glu Tyr Trp Ser Tyr Asp Leu Gly Ala Leu Glu 
            260                 265                 270         


Asn Tyr Leu Asn Lys Thr Asn Phe Asn His Ser Val Phe Asp Val Pro 
        275                 280                 285             


Leu His Tyr Gln Phe His Ala Ala Ser Thr Gln Gly Gly Gly Tyr Asp 
    290                 295                 300                 


Met Arg Lys Leu Leu Asn Gly Thr Val Val Ser Lys His Pro Leu Lys 
305                 310                 315                 320 


Ser Val Thr Phe Val Asp Asn His Asp Thr Gln Pro Gly Gln Ser Leu 
                325                 330                 335     


Glu Ser Thr Val Gln Thr Trp Phe Lys Pro Leu Ala Tyr Ala Phe Ile 
            340                 345                 350         


Leu Thr Arg Glu Ser Gly Tyr Pro Gln Val Phe Tyr Gly Asp Met Tyr 
        355                 360                 365             


Gly Thr Lys Gly Asp Ser Gln Arg Glu Ile Pro Ala Leu Lys His Lys 
    370                 375                 380                 


Ile Glu Pro Ile Leu Lys Ala Arg Lys Gln Tyr Ala Tyr Gly Ala Gln 
385                 390                 395                 400 


His Asp Tyr Phe Asp His His Asp Ile Val Gly Trp Thr Arg Glu Gly 
                405                 410                 415     


Asp Ser Ser Val Ala Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly 
            420                 425                 430         


Pro Gly Gly Ala Lys Arg Met Tyr Val Gly Arg Gln Asn Ala Gly Glu 
        435                 440                 445             


Thr Trp His Asp Ile Thr Gly Asn Arg Ser Glu Pro Val Val Ile Asn 
    450                 455                 460                 


Ser Ala Gly Trp Gly Glu Phe His Val Asn Gly Gly Ser Val Ser Ile 
465                 470                 475                 480 


Tyr Val Gln Arg 
                


<210>  120
<211>  485
<212>  PRT
<213>  Artifical Sequence

<400>  120

Ala Asn Leu Asn Gly Thr Leu Met Gln Tyr Phe Glu Trp Tyr Met Pro 
1               5                   10                  15      


Asn Asp Gly Gln His Trp Lys Arg Leu Gln Asn Asp Ser Ala Tyr Leu 
            20                  25                  30          


Ala Glu His Gly Ile Thr Ala Val Trp Ile Pro Pro Ala Tyr Lys Gly 
        35                  40                  45              


Thr Ser Gln Ala Asp Val Gly Tyr Gly Ala Tyr Asp Leu Tyr Asp Leu 
    50                  55                  60                  


Gly Glu Phe His Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly Thr Lys 
65                  70                  75                  80  


Gly Glu Leu Gln Ser Ala Ile Lys Ser Leu His Ser Arg Asp Ile Asn 
                85                  90                  95      


Val Tyr Gly Asp Val Val Ile Asn His Lys Ala Gly Ala Asp Gly Thr 
            100                 105                 110         


Glu Phe Val Asp Ala Val Glu Val Asn Pro Ser Asn Arg Asn Gln Glu 
        115                 120                 125             


Thr Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp Phe Pro 
    130                 135                 140                 


Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr His Phe 
145                 150                 155                 160 


Asp Gly Thr Asp Trp Asp Glu Ser Arg Lys Leu Asn Arg Ile Tyr Lys 
                165                 170                 175     


Phe Arg Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Asp Thr Glu Asn 
            180                 185                 190         


Gly Asn Tyr Asp Tyr Leu Met Phe Ala Asp Leu Asp Tyr Asp His Pro 
        195                 200                 205             


Asp Val Ala Ala Glu Ile Lys Arg Trp Gly Thr Trp Tyr Ala Asn Glu 
    210                 215                 220                 


Leu Gln Leu Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile Lys Phe 
225                 230                 235                 240 


Ser Phe Leu Arg Asp Trp Val Asn His Val Arg Glu Lys Thr Gly Lys 
                245                 250                 255     


Glu Met Phe Thr Val Ala Glu Tyr Trp Ser Tyr Asp Leu Gly Ala Leu 
            260                 265                 270         


Glu Asn Tyr Leu Asn Lys Thr Asn Phe Asn His Ser Val Phe Asp Val 
        275                 280                 285             


Pro Leu His Tyr Gln Phe His Ala Ala Ser Thr Gln Gly Gly Gly Tyr 
    290                 295                 300                 


Asp Met Arg Lys Leu Leu Asn Gly Thr Val Val Ser Lys His Pro Leu 
305                 310                 315                 320 


Lys Ser Val Thr Phe Val Asp Asn His Asp Thr Gln Pro Gly Gln Ser 
                325                 330                 335     


Leu Glu Ser Thr Val Gln Thr Trp Phe Lys Pro Leu Ala Tyr Ala Phe 
            340                 345                 350         


Ile Leu Thr Arg Glu Ser Gly Tyr Pro Gln Val Phe Tyr Gly Asp Met 
        355                 360                 365             


Tyr Gly Thr Lys Gly Asp Ser Gln Arg Glu Ile Pro Ala Leu Lys His 
    370                 375                 380                 


Lys Ile Glu Pro Ile Leu Lys Ala Arg Lys Gln Tyr Ala Tyr Gly Ala 
385                 390                 395                 400 


Gln His Asp Tyr Phe Asp His His Asp Ile Val Gly Trp Thr Arg Glu 
                405                 410                 415     


Gly Asp Ser Ser Val Ala Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp 
            420                 425                 430         


Gly Pro Gly Gly Ala Lys Arg Met Tyr Val Gly Arg Gln Asn Ala Gly 
        435                 440                 445             


Glu Thr Trp His Asp Ile Thr Gly Asn Arg Ser Glu Pro Val Val Ile 
    450                 455                 460                 


Asn Ser Ala Gly Trp Gly Glu Phe His Val Asn Gly Gly Ser Val Ser 
465                 470                 475                 480 


Ile Tyr Val Gln Arg 
                485 


<210>  121
<211>  485
<212>  PRT
<213>  Artifical Sequence

<400>  121

Ala Asn Leu Asn Gly Thr Leu Met Gln Tyr Phe Glu Trp Tyr Met Pro 
1               5                   10                  15      


Asn Asp Gly Gln His Trp Lys Arg Leu Gln Asn Asp Ser Ala Tyr Leu 
            20                  25                  30          


Ala Glu His Gly Ile Thr Ala Val Trp Ile Pro Pro Ala Tyr Lys Gly 
        35                  40                  45              


Thr Ser Gln Ala Asp Val Gly Tyr Gly Ala Tyr Asp Leu Tyr Asp Leu 
    50                  55                  60                  


Gly Glu Phe His Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly Thr Lys 
65                  70                  75                  80  


Gly Glu Leu Gln Ser Ala Ile Lys Ser Leu His Ser Arg Asp Ile Asn 
                85                  90                  95      


Val Tyr Gly Asp Val Val Ile Asn His Lys Ala Gly Ala Asp Ala Thr 
            100                 105                 110         


Glu Trp Val Asp Ala Val Glu Val Asn Pro Ser Asn Arg Asn Gln Glu 
        115                 120                 125             


Val Ser Gly Thr Tyr Lys Ile Gln Ala Trp Thr Lys Phe Asp Phe Pro 
    130                 135                 140                 


Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr His Phe 
145                 150                 155                 160 


Asp Gly Thr Asp Trp Asp Gln Ser Arg Gln Leu Asn Arg Ile Tyr Lys 
                165                 170                 175     


Phe Arg Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Asp Thr Glu Asn 
            180                 185                 190         


Gly Asn Tyr Asp Tyr Leu Met Phe Ala Asp Leu Asp Tyr Asp His Pro 
        195                 200                 205             


Asp Val Ala Ala Glu Ile Lys Arg Trp Gly Thr Trp Tyr Ala Asn Glu 
    210                 215                 220                 


Leu Gln Leu Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile Lys Phe 
225                 230                 235                 240 


Ser Phe Leu Arg Asp Trp Val Asn His Val Arg Glu Lys Thr Gly Lys 
                245                 250                 255     


Glu Met Phe Thr Val Ala Glu Tyr Trp Ser Tyr Asp Leu Gly Ala Leu 
            260                 265                 270         


Glu Asn Tyr Leu Asn Lys Thr Asn Phe Asn His Ser Val Phe Asp Val 
        275                 280                 285             


Pro Leu His Tyr Gln Phe His Ala Ala Ser Thr Gln Gly Gly Gly Tyr 
    290                 295                 300                 


Asp Met Arg Lys Leu Leu Asn Gly Thr Val Val Ser Lys His Pro Leu 
305                 310                 315                 320 


Lys Ser Val Thr Phe Val Asp Asn His Asp Thr Gln Pro Gly Gln Ser 
                325                 330                 335     


Leu Glu Ser Thr Val Gln Thr Trp Phe Lys Pro Leu Ala Tyr Ala Phe 
            340                 345                 350         


Ile Leu Thr Arg Glu Ser Gly Tyr Pro Gln Val Phe Tyr Gly Asp Met 
        355                 360                 365             


Tyr Gly Thr Lys Gly Asp Ser Gln Arg Glu Ile Pro Ala Leu Lys His 
    370                 375                 380                 


Lys Ile Glu Pro Ile Leu Lys Ala Arg Lys Gln Tyr Ala Tyr Gly Ala 
385                 390                 395                 400 


Gln His Asp Tyr Phe Asp His His Asp Ile Val Gly Trp Thr Arg Glu 
                405                 410                 415     


Gly Asp Ser Ser Val Ala Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp 
            420                 425                 430         


Gly Pro Gly Gly Ala Lys Arg Met Tyr Val Gly Arg Gln Asn Ala Gly 
        435                 440                 445             


Glu Thr Trp His Asp Ile Thr Gly Asn Arg Ser Glu Pro Val Val Ile 
    450                 455                 460                 


Asn Ser Ala Gly Trp Gly Glu Phe His Val Asn Gly Gly Ser Val Ser 
465                 470                 475                 480 


Ile Tyr Val Gln Arg 
                485 


<210>  122
<211>  485
<212>  PRT
<213>  Artifical Sequence

<400>  122

Ala Asn Leu Asn Gly Thr Leu Met Gln Tyr Phe Glu Trp Tyr Met Pro 
1               5                   10                  15      


Asn Asp Gly Gln His Trp Lys Arg Leu Gln Asn Asp Ser Ala Tyr Leu 
            20                  25                  30          


Ala Glu His Gly Ile Thr Ala Val Trp Ile Pro Pro Ala Tyr Lys Gly 
        35                  40                  45              


Thr Ser Gln Ala Asp Val Gly Tyr Gly Ala Tyr Asp Leu Tyr Asp Leu 
    50                  55                  60                  


Gly Glu Phe His Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly Thr Lys 
65                  70                  75                  80  


Gly Glu Leu Gln Ser Ala Ile Lys Ser Leu His Ser Arg Asp Ile Asn 
                85                  90                  95      


Val Tyr Gly Asp Val Val Ile Asn His Lys Ala Gly Ala Asp Ser Thr 
            100                 105                 110         


Glu Trp Val Asp Ala Val Glu Val Asn Pro Ser Asn Arg Asn Gln Glu 
        115                 120                 125             


Thr Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp Phe Pro 
    130                 135                 140                 


Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr His Phe 
145                 150                 155                 160 


Asp Gly Thr Asp Trp Asp Glu Ser Arg Lys Leu Asn Arg Ile Tyr Lys 
                165                 170                 175     


Phe Arg Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Asp Thr Glu Asn 
            180                 185                 190         


Gly Asn Tyr Asp Tyr Leu Met Phe Ala Asp Leu Asp Tyr Asp His Pro 
        195                 200                 205             


Asp Val Ala Ala Glu Ile Lys Arg Trp Gly Thr Trp Tyr Ala Asn Glu 
    210                 215                 220                 


Leu Gln Leu Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile Lys Phe 
225                 230                 235                 240 


Ser Phe Leu Arg Asp Trp Val Asn His Val Arg Glu Lys Thr Gly Lys 
                245                 250                 255     


Glu Met Phe Thr Val Ala Glu Tyr Trp Ser Tyr Asp Leu Gly Ala Leu 
            260                 265                 270         


Glu Asn Tyr Leu Asn Lys Thr Asn Phe Asn His Ser Val Phe Asp Val 
        275                 280                 285             


Pro Leu His Tyr Gln Phe His Ala Ala Ser Thr Gln Gly Gly Gly Tyr 
    290                 295                 300                 


Asp Met Arg Lys Leu Leu Asn Gly Thr Val Val Ser Lys His Pro Leu 
305                 310                 315                 320 


Lys Ser Val Thr Phe Val Asp Asn His Asp Thr Gln Pro Gly Gln Ser 
                325                 330                 335     


Leu Glu Ser Thr Val Gln Thr Trp Phe Lys Pro Leu Ala Tyr Ala Phe 
            340                 345                 350         


Ile Leu Thr Arg Glu Ser Gly Tyr Pro Gln Val Phe Tyr Gly Asp Met 
        355                 360                 365             


Tyr Gly Thr Lys Gly Asp Ser Gln Arg Glu Ile Pro Ala Leu Lys His 
    370                 375                 380                 


Lys Ile Glu Pro Ile Leu Lys Ala Arg Lys Gln Tyr Ala Tyr Gly Ala 
385                 390                 395                 400 


Gln His Asp Tyr Phe Asp His His Asp Ile Val Gly Trp Thr Arg Glu 
                405                 410                 415     


Gly Asp Ser Ser Val Ala Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp 
            420                 425                 430         


Gly Pro Gly Gly Ala Lys Arg Met Tyr Val Gly Arg Gln Asn Ala Gly 
        435                 440                 445             


Glu Thr Trp His Asp Ile Thr Gly Asn Arg Ser Glu Pro Val Val Ile 
    450                 455                 460                 


Asn Ser Ala Gly Trp Gly Glu Phe His Val Asn Gly Gly Ser Val Ser 
465                 470                 475                 480 


Ile Tyr Val Gln Arg 
                485 


<210>  123
<211>  486
<212>  PRT
<213>  Artifical Sequence

<400>  123

Ala Asn Leu Asn Gly Thr Leu Met Gln Tyr Phe Glu Trp Tyr Met Pro 
1               5                   10                  15      


Asn Asp Gly Gln His Trp Lys Arg Leu Gln Asn Asp Ser Ala Tyr Leu 
            20                  25                  30          


Ala Glu His Gly Ile Thr Ala Val Trp Ile Pro Pro Ala Tyr Lys Gly 
        35                  40                  45              


Thr Ser Gln Ala Asp Val Gly Tyr Gly Ala Tyr Asp Leu Tyr Asp Leu 
    50                  55                  60                  


Gly Glu Phe His Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly Thr Lys 
65                  70                  75                  80  


Gly Glu Leu Gln Ser Ala Ile Lys Ser Leu His Ser Arg Asp Ile Asn 
                85                  90                  95      


Val Tyr Gly Asp Val Val Ile Asn His Lys Gly Gly Ala Asp Phe Thr 
            100                 105                 110         


Glu Arg Val Gln Ala Val Glu Val Asn Pro Gln Asn Arg Asn Gln Glu 
        115                 120                 125             


Val Ser Gly Thr Tyr Gln Ile Glu Ala Trp Thr Gly Phe Asn Phe Pro 
    130                 135                 140                 


Gly Arg Gly Asn Gln His Ser Ser Phe Lys Trp Arg Trp Tyr His Phe 
145                 150                 155                 160 


Asp Gly Thr Asp Trp Asp Gln Ser Arg Gln Leu Ala Asn Arg Ile Tyr 
                165                 170                 175     


Lys Phe Arg Gly Asp Gly Lys Ala Trp Asp Trp Glu Val Asp Thr Glu 
            180                 185                 190         


Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Val Asp Tyr Asp His 
        195                 200                 205             


Pro Asp Val Ala Ala Glu Ile Lys Arg Trp Gly Thr Trp Tyr Ala Asn 
    210                 215                 220                 


Glu Leu Gln Leu Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile Lys 
225                 230                 235                 240 


Phe Ser Phe Leu Arg Asp Trp Val Asn His Val Arg Glu Lys Thr Gly 
                245                 250                 255     


Lys Glu Met Phe Thr Val Ala Glu Tyr Trp Ser Tyr Asp Leu Gly Ala 
            260                 265                 270         


Leu Glu Asn Tyr Leu Asn Lys Thr Asn Phe Asn His Ser Val Phe Asp 
        275                 280                 285             


Val Pro Leu His Tyr Gln Phe His Ala Ala Ser Thr Gln Gly Gly Gly 
    290                 295                 300                 


Tyr Asp Met Arg Lys Leu Leu Asn Gly Thr Val Val Ser Lys His Pro 
305                 310                 315                 320 


Leu Lys Ser Val Thr Phe Val Asp Asn His Asp Thr Gln Pro Gly Gln 
                325                 330                 335     


Ser Leu Glu Ser Thr Val Gln Thr Trp Phe Lys Pro Leu Ala Tyr Ala 
            340                 345                 350         


Phe Ile Leu Thr Arg Glu Ser Gly Tyr Pro Gln Val Phe Tyr Gly Asp 
        355                 360                 365             


Met Tyr Gly Thr Lys Gly Asp Ser Gln Arg Glu Ile Pro Ala Leu Lys 
    370                 375                 380                 


His Lys Ile Glu Pro Ile Leu Lys Ala Arg Lys Gln Tyr Ala Tyr Gly 
385                 390                 395                 400 


Ala Gln His Asp Tyr Phe Asp His His Asp Ile Val Gly Trp Thr Arg 
                405                 410                 415     


Glu Gly Asp Ser Ser Val Ala Asn Ser Gly Leu Ala Ala Leu Ile Thr 
            420                 425                 430         


Asp Gly Pro Gly Gly Ala Lys Arg Met Tyr Val Gly Arg Gln Asn Ala 
        435                 440                 445             


Gly Glu Thr Trp His Asp Ile Thr Gly Asn Arg Ser Glu Pro Val Val 
    450                 455                 460                 


Ile Asn Ser Ala Gly Trp Gly Glu Phe His Val Asn Gly Gly Ser Val 
465                 470                 475                 480 


Ser Ile Tyr Val Gln Arg 
                485     


<210>  124
<211>  486
<212>  PRT
<213>  Artifical Sequence

<400>  124

Ala Asn Leu Asn Gly Thr Leu Met Gln Tyr Phe Glu Trp Tyr Met Pro 
1               5                   10                  15      


Asn Asp Gly Gln His Trp Lys Arg Leu Gln Asn Asp Ser Ala Tyr Leu 
            20                  25                  30          


Ala Glu His Gly Ile Thr Ala Val Trp Ile Pro Pro Ala Tyr Lys Gly 
        35                  40                  45              


Thr Ser Gln Ala Asp Val Gly Tyr Gly Ala Tyr Asp Leu Tyr Asp Leu 
    50                  55                  60                  


Gly Glu Phe His Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly Thr Lys 
65                  70                  75                  80  


Gly Glu Leu Gln Ser Ala Ile Lys Ser Leu His Ser Arg Asp Ile Asn 
                85                  90                  95      


Val Tyr Gly Asp Val Val Ile Asn His Lys Gly Gly Ala Asp Ala Thr 
            100                 105                 110         


Glu Asn Val Leu Ala Val Glu Val Asn Pro Asn Asn Arg Asn Gln Glu 
        115                 120                 125             


Ile Ser Gly Asp Tyr Thr Ile Glu Ala Trp Thr Lys Phe Asp Phe Pro 
    130                 135                 140                 


Gly Arg Gly Asn Thr Tyr Ser Asp Phe Lys Trp Arg Trp Tyr His Phe 
145                 150                 155                 160 


Asp Gly Val Asp Trp Asp Gln Ser Arg Gln Phe Gln Asn Arg Ile Tyr 
                165                 170                 175     


Lys Phe Arg Gly Asp Gly Lys Ala Trp Asp Trp Glu Val Asp Ser Glu 
            180                 185                 190         


Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Val Asp Tyr Asp His 
        195                 200                 205             


Pro Asp Val Ala Ala Glu Ile Lys Arg Trp Gly Thr Trp Tyr Ala Asn 
    210                 215                 220                 


Glu Leu Gln Leu Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile Lys 
225                 230                 235                 240 


Phe Ser Phe Leu Arg Asp Trp Val Asn His Val Arg Glu Lys Thr Gly 
                245                 250                 255     


Lys Glu Met Phe Thr Val Ala Glu Tyr Trp Ser Tyr Asp Leu Gly Ala 
            260                 265                 270         


Leu Glu Asn Tyr Leu Asn Lys Thr Asn Phe Asn His Ser Val Phe Asp 
        275                 280                 285             


Val Pro Leu His Tyr Gln Phe His Ala Ala Ser Thr Gln Gly Gly Gly 
    290                 295                 300                 


Tyr Asp Met Arg Lys Leu Leu Asn Gly Thr Val Val Ser Lys His Pro 
305                 310                 315                 320 


Leu Lys Ser Val Thr Phe Val Asp Asn His Asp Thr Gln Pro Gly Gln 
                325                 330                 335     


Ser Leu Glu Ser Thr Val Gln Thr Trp Phe Lys Pro Leu Ala Tyr Ala 
            340                 345                 350         


Phe Ile Leu Thr Arg Glu Ser Gly Tyr Pro Gln Val Phe Tyr Gly Asp 
        355                 360                 365             


Met Tyr Gly Thr Lys Gly Asp Ser Gln Arg Glu Ile Pro Ala Leu Lys 
    370                 375                 380                 


His Lys Ile Glu Pro Ile Leu Lys Ala Arg Lys Gln Tyr Ala Tyr Gly 
385                 390                 395                 400 


Ala Gln His Asp Tyr Phe Asp His His Asp Ile Val Gly Trp Thr Arg 
                405                 410                 415     


Glu Gly Asp Ser Ser Val Ala Asn Ser Gly Leu Ala Ala Leu Ile Thr 
            420                 425                 430         


Asp Gly Pro Gly Gly Ala Lys Arg Met Tyr Val Gly Arg Gln Asn Ala 
        435                 440                 445             


Gly Glu Thr Trp His Asp Ile Thr Gly Asn Arg Ser Glu Pro Val Val 
    450                 455                 460                 


Ile Asn Ser Ala Gly Trp Gly Glu Phe His Val Asn Gly Gly Ser Val 
465                 470                 475                 480 


Ser Ile Tyr Val Gln Arg 
                485     


<210>  125
<211>  486
<212>  PRT
<213>  Artifiical Sequence

<400>  125

Ala Asn Leu Asn Gly Thr Leu Met Gln Tyr Phe Glu Trp Tyr Met Pro 
1               5                   10                  15      


Asn Asp Gly Gln His Trp Lys Arg Leu Gln Asn Asp Ser Ala Tyr Leu 
            20                  25                  30          


Ala Glu His Gly Ile Thr Ala Val Trp Ile Pro Pro Ala Tyr Lys Gly 
        35                  40                  45              


Thr Ser Gln Ala Asp Val Gly Tyr Gly Ala Tyr Asp Leu Tyr Asp Leu 
    50                  55                  60                  


Gly Glu Phe His Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly Thr Lys 
65                  70                  75                  80  


Gly Glu Leu Gln Ser Ala Ile Lys Ser Leu His Ser Arg Asp Ile Asn 
                85                  90                  95      


Val Tyr Gly Asp Val Val Ile Asn His Lys Gly Gly Ala Asp Ala Thr 
            100                 105                 110         


Glu Met Val Arg Ala Val Glu Val Asn Pro Asn Asn Arg Asn Gln Glu 
        115                 120                 125             


Val Ser Gly Glu Tyr Thr Ile Glu Ala Trp Thr Lys Phe Asp Phe Pro 
    130                 135                 140                 


Gly Arg Gly Asn Thr His Ser Asn Phe Lys Trp Arg Trp Tyr His Phe 
145                 150                 155                 160 


Asp Gly Val Asp Trp Asp Gln Ser Arg Lys Leu Asn Asn Arg Ile Tyr 
                165                 170                 175     


Lys Phe Arg Gly Asp Gly Lys Gly Trp Asp Trp Glu Val Asp Thr Glu 
            180                 185                 190         


Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Ile Asp Tyr Asp His 
        195                 200                 205             


Pro Asp Val Ala Ala Glu Ile Lys Arg Trp Gly Thr Trp Tyr Ala Asn 
    210                 215                 220                 


Glu Leu Gln Leu Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile Lys 
225                 230                 235                 240 


Phe Ser Phe Leu Arg Asp Trp Val Asn His Val Arg Glu Lys Thr Gly 
                245                 250                 255     


Lys Glu Met Phe Thr Val Ala Glu Tyr Trp Ser Tyr Asp Leu Gly Ala 
            260                 265                 270         


Leu Glu Asn Tyr Leu Asn Lys Thr Asn Phe Asn His Ser Val Phe Asp 
        275                 280                 285             


Val Pro Leu His Tyr Gln Phe His Ala Ala Ser Thr Gln Gly Gly Gly 
    290                 295                 300                 


Tyr Asp Met Arg Lys Leu Leu Asn Gly Thr Val Val Ser Lys His Pro 
305                 310                 315                 320 


Leu Lys Ser Val Thr Phe Val Asp Asn His Asp Thr Gln Pro Gly Gln 
                325                 330                 335     


Ser Leu Glu Ser Thr Val Gln Thr Trp Phe Lys Pro Leu Ala Tyr Ala 
            340                 345                 350         


Phe Ile Leu Thr Arg Glu Ser Gly Tyr Pro Gln Val Phe Tyr Gly Asp 
        355                 360                 365             


Met Tyr Gly Thr Lys Gly Asp Ser Gln Arg Glu Ile Pro Ala Leu Lys 
    370                 375                 380                 


His Lys Ile Glu Pro Ile Leu Lys Ala Arg Lys Gln Tyr Ala Tyr Gly 
385                 390                 395                 400 


Ala Gln His Asp Tyr Phe Asp His His Asp Ile Val Gly Trp Thr Arg 
                405                 410                 415     


Glu Gly Asp Ser Ser Val Ala Asn Ser Gly Leu Ala Ala Leu Ile Thr 
            420                 425                 430         


Asp Gly Pro Gly Gly Ala Lys Arg Met Tyr Val Gly Arg Gln Asn Ala 
        435                 440                 445             


Gly Glu Thr Trp His Asp Ile Thr Gly Asn Arg Ser Glu Pro Val Val 
    450                 455                 460                 


Ile Asn Ser Ala Gly Trp Gly Glu Phe His Val Asn Gly Gly Ser Val 
465                 470                 475                 480 


Ser Ile Tyr Val Gln Arg 
                485     


<210>  126
<211>  486
<212>  PRT
<213>  Artifical Sequence

<400>  126

Ala Asn Leu Asn Gly Thr Leu Met Gln Tyr Phe Glu Trp Tyr Met Pro 
1               5                   10                  15      


Asn Asp Gly Gln His Trp Lys Arg Leu Gln Asn Asp Ser Ala Tyr Leu 
            20                  25                  30          


Ala Glu His Gly Ile Thr Ala Val Trp Ile Pro Pro Ala Tyr Lys Gly 
        35                  40                  45              


Thr Ser Gln Ala Asp Val Gly Tyr Gly Ala Tyr Asp Leu Tyr Asp Leu 
    50                  55                  60                  


Gly Glu Phe His Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly Thr Lys 
65                  70                  75                  80  


Gly Glu Leu Gln Ser Ala Ile Lys Ser Leu His Ser Arg Asp Ile Asn 
                85                  90                  95      


Val Tyr Gly Asp Val Val Ile Asn His Lys Gly Gly Ala Asp Ala Thr 
            100                 105                 110         


Glu Met Val Arg Ala Val Glu Val Asn Pro Asn Asn Arg Asn Gln Glu 
        115                 120                 125             


Val Thr Gly Glu Tyr Thr Ile Glu Ala Trp Thr Arg Phe Asp Phe Pro 
    130                 135                 140                 


Gly Arg Gly Asn Thr His Ser Ser Phe Lys Trp Arg Trp Tyr His Phe 
145                 150                 155                 160 


Asp Gly Val Asp Trp Asp Gln Ser Arg Arg Leu Asn Asn Arg Ile Tyr 
                165                 170                 175     


Lys Phe Arg Gly His Gly Lys Ala Trp Asp Trp Glu Val Asp Thr Glu 
            180                 185                 190         


Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Ile Asp Tyr Asp His 
        195                 200                 205             


Pro Asp Val Ala Ala Glu Ile Lys Arg Trp Gly Thr Trp Tyr Ala Asn 
    210                 215                 220                 


Glu Leu Gln Leu Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile Lys 
225                 230                 235                 240 


Phe Ser Phe Leu Arg Asp Trp Val Asn His Val Arg Glu Lys Thr Gly 
                245                 250                 255     


Lys Glu Met Phe Thr Val Ala Glu Tyr Trp Ser Tyr Asp Leu Gly Ala 
            260                 265                 270         


Leu Glu Asn Tyr Leu Asn Lys Thr Asn Phe Asn His Ser Val Phe Asp 
        275                 280                 285             


Val Pro Leu His Tyr Gln Phe His Ala Ala Ser Thr Gln Gly Gly Gly 
    290                 295                 300                 


Tyr Asp Met Arg Lys Leu Leu Asn Gly Thr Val Val Ser Lys His Pro 
305                 310                 315                 320 


Leu Lys Ser Val Thr Phe Val Asp Asn His Asp Thr Gln Pro Gly Gln 
                325                 330                 335     


Ser Leu Glu Ser Thr Val Gln Thr Trp Phe Lys Pro Leu Ala Tyr Ala 
            340                 345                 350         


Phe Ile Leu Thr Arg Glu Ser Gly Tyr Pro Gln Val Phe Tyr Gly Asp 
        355                 360                 365             


Met Tyr Gly Thr Lys Gly Asp Ser Gln Arg Glu Ile Pro Ala Leu Lys 
    370                 375                 380                 


His Lys Ile Glu Pro Ile Leu Lys Ala Arg Lys Gln Tyr Ala Tyr Gly 
385                 390                 395                 400 


Ala Gln His Asp Tyr Phe Asp His His Asp Ile Val Gly Trp Thr Arg 
                405                 410                 415     


Glu Gly Asp Ser Ser Val Ala Asn Ser Gly Leu Ala Ala Leu Ile Thr 
            420                 425                 430         


Asp Gly Pro Gly Gly Ala Lys Arg Met Tyr Val Gly Arg Gln Asn Ala 
        435                 440                 445             


Gly Glu Thr Trp His Asp Ile Thr Gly Asn Arg Ser Glu Pro Val Val 
    450                 455                 460                 


Ile Asn Ser Ala Gly Trp Gly Glu Phe His Val Asn Gly Gly Ser Val 
465                 470                 475                 480 


Ser Ile Tyr Val Gln Arg 
                485     


<210>  127
<211>  485
<212>  PRT
<213>  Artifical Sequence

<400>  127

Thr Phe Ala Gly Asp Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr 
1               5                   10                  15      


Leu Pro Asn Asp Gly Thr Leu Trp Thr Lys Met Gly Ser Asp Ala Ser 
            20                  25                  30          


His Leu Lys Ser Ile Gly Ile Thr Gly Val Trp Phe Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Gln Ser Gln Ser Asp Val Gly Tyr Gly Val Tyr Asp Met Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Ala Gln Leu Gln Ser Ala Ile Thr Ser Leu His Asn Asn Gly 
                85                  90                  95      


Ile Gln Ala Tyr Gly Asp Val Val Leu Asn His Lys Ala Gly Ala Asp 
            100                 105                 110         


Ala Thr Glu Asp Val Thr Ala Val Glu Val Asn Pro Ala Asn Arg Asn 
        115                 120                 125             


Gln Glu Thr Ser Glu Glu Tyr Gln Ile Lys Ala Trp Thr Asp Phe Arg 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Asp Phe Lys Trp His Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Ala Asp Trp Asp Glu Ser Arg Lys Ile Ser Arg Ile 
                165                 170                 175     


Phe Lys Phe Arg Gly Glu Gly Lys Ala Trp Asp Trp Glu Val Ser Ser 
            180                 185                 190         


Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Val Asp Tyr Asp 
        195                 200                 205             


His Pro Asp Val Gln Thr Glu Val Lys Asn Trp Gly Lys Trp Phe Val 
    210                 215                 220                 


Asn Thr Leu Asn Leu Asp Gly Val Arg Leu Asp Ala Val Lys His Ile 
225                 230                 235                 240 


Lys Phe Asp Tyr Met Ser Ser Trp Leu Ser Ser Val Lys Ser Thr Thr 
                245                 250                 255     


Gly Lys Ser Asn Leu Phe Ala Val Gly Glu Tyr Trp Asn Thr Ser Leu 
            260                 265                 270         


Gly Ala Leu Glu Asn Tyr Glu Asn Lys Thr Asn Trp Ser Met Ser Leu 
        275                 280                 285             


Phe Asp Val Pro Leu His Met Asn Phe Gln Ala Ala Ala Asn Gly Gly 
    290                 295                 300                 


Gly Tyr Tyr Asp Met Arg Asn Leu Leu Asn Asn Thr Met Met Lys Asn 
305                 310                 315                 320 


His Pro Ile Gln Ala Val Thr Phe Val Asp Asn His Asp Thr Glu Pro 
                325                 330                 335     


Gly Gln Ala Leu Gln Ser Trp Val Ser Asp Trp Phe Lys Pro Leu Ala 
            340                 345                 350         


Tyr Ala Thr Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr 
        355                 360                 365             


Gly Asp Tyr Tyr Gly Ile Pro Ser Gln Ser Val Ser Ala Lys Ser Thr 
    370                 375                 380                 


Trp Leu Asp Lys Gln Leu Ser Ala Arg Lys Ser Tyr Ala Tyr Gly Thr 
385                 390                 395                 400 


Gln His Asp Tyr Leu Asp Asn Gln Asp Val Ile Gly Trp Thr Arg Glu 
                405                 410                 415     


Gly Asp Ser Ala His Ala Gly Ser Gly Leu Ala Thr Val Met Ser Asp 
            420                 425                 430         


Gly Pro Gly Gly Ser Lys Thr Met Tyr Val Gly Thr Ala His Ala Gly 
        435                 440                 445             


Gln Val Phe Lys Asp Ile Thr Gly Asn Arg Thr Asp Thr Val Thr Ile 
    450                 455                 460                 


Asn Ser Ala Gly Asn Gly Thr Phe Pro Cys Asn Gly Gly Ser Val Ser 
465                 470                 475                 480 


Ile Trp Val Lys Gln 
                485 


<210>  128
<211>  483
<212>  PRT
<213>  Artifical Sequence

<400>  128

Thr Phe Ala Gly Asp Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr 
1               5                   10                  15      


Leu Pro Asn Asp Gly Thr Leu Trp Thr Lys Met Gly Ser Asp Ala Ser 
            20                  25                  30          


His Leu Lys Ser Ile Gly Ile Thr Gly Val Trp Phe Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Gln Ser Gln Ser Asp Val Gly Tyr Gly Val Tyr Asp Met Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Ala Gln Leu Gln Ser Ala Ile Thr Ser Leu His Asn Asn Gly 
                85                  90                  95      


Ile Gln Ala Tyr Gly Asp Val Val Leu Asn His Lys Gly Gly Ala Asp 
            100                 105                 110         


Ala Thr Glu Asp Val Thr Ala Val Glu Val Asp Pro Ala Asp Arg Asn 
        115                 120                 125             


Arg Val Ile Ser Gly Glu His Leu Ile Lys Ala Trp Thr His Phe His 
    130                 135                 140                 


Phe Pro Gly Arg Gly Ser Thr Tyr Ser Asp Phe Lys Trp His Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Glu Ser Arg Lys Leu Asn Arg Ile 
                165                 170                 175     


Tyr Lys Phe Gln Gly Lys Ala Trp Asp Trp Glu Val Ser Asn Glu Phe 
            180                 185                 190         


Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Ile Asp Tyr Asp His Pro 
        195                 200                 205             


Asp Val Gln Thr Glu Val Lys Asn Trp Gly Lys Trp Phe Val Asn Thr 
    210                 215                 220                 


Leu Asn Leu Asp Gly Val Arg Leu Asp Ala Val Lys His Ile Lys Phe 
225                 230                 235                 240 


Asp Tyr Met Ser Ser Trp Leu Ser Ser Val Lys Ser Thr Thr Gly Lys 
                245                 250                 255     


Ser Asn Leu Phe Ala Val Gly Glu Tyr Trp Asn Thr Ser Leu Gly Ala 
            260                 265                 270         


Leu Glu Asn Tyr Glu Asn Lys Thr Asn Trp Ser Met Ser Leu Phe Asp 
        275                 280                 285             


Val Pro Leu His Met Asn Phe Gln Ala Ala Ala Asn Gly Gly Gly Tyr 
    290                 295                 300                 


Tyr Asp Met Arg Asn Leu Leu Asn Asn Thr Met Met Lys Asn His Pro 
305                 310                 315                 320 


Ile Gln Ala Val Thr Phe Val Asp Asn His Asp Thr Glu Pro Gly Gln 
                325                 330                 335     


Ala Leu Gln Ser Trp Val Ser Asp Trp Phe Lys Pro Leu Ala Tyr Ala 
            340                 345                 350         


Thr Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr Gly Asp 
        355                 360                 365             


Tyr Tyr Gly Ile Pro Ser Gln Ser Val Ser Ala Lys Ser Thr Trp Leu 
    370                 375                 380                 


Asp Lys Gln Leu Ser Ala Arg Lys Ser Tyr Ala Tyr Gly Thr Gln His 
385                 390                 395                 400 


Asp Tyr Leu Asp Asn Gln Asp Val Ile Gly Trp Thr Arg Glu Gly Asp 
                405                 410                 415     


Ser Ala His Ala Gly Ser Gly Leu Ala Thr Val Met Ser Asp Gly Pro 
            420                 425                 430         


Gly Gly Ser Lys Thr Met Tyr Val Gly Thr Ala His Ala Gly Gln Val 
        435                 440                 445             


Phe Lys Asp Ile Thr Gly Asn Arg Thr Asp Thr Val Thr Ile Asn Ser 
    450                 455                 460                 


Ala Gly Asn Gly Thr Phe Pro Cys Asn Gly Gly Ser Val Ser Ile Trp 
465                 470                 475                 480 


Val Lys Gln 
            


<210>  129
<211>  485
<212>  PRT
<213>  Artifical Sequence

<400>  129

Thr Phe Ala Gly Asp Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr 
1               5                   10                  15      


Leu Pro Asn Asp Gly Thr Leu Trp Thr Lys Met Gly Ser Asp Ala Ser 
            20                  25                  30          


His Leu Lys Ser Ile Gly Ile Thr Gly Val Trp Phe Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Gln Ser Gln Ser Asp Val Gly Tyr Gly Val Tyr Asp Met Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Ala Gln Leu Gln Ser Ala Ile Thr Ser Leu His Asn Asn Gly 
                85                  90                  95      


Ile Gln Ala Tyr Gly Asp Val Val Leu Asn His Lys Ala Gly Ala Asp 
            100                 105                 110         


Tyr Thr Glu Asn Val Thr Ala Val Glu Val Asn Pro Ser Asn Arg Asn 
        115                 120                 125             


Gln Glu Thr Ser Gly Glu Tyr Asn Ile Gln Ala Trp Thr Gly Phe Asn 
    130                 135                 140                 


Phe Pro Gly Arg Gly Thr Thr Tyr Ser Asn Phe Lys Trp Gln Trp Phe 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Gln Ser Arg Ser Leu Ser Arg Ile 
                165                 170                 175     


Phe Lys Phe Arg Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Ser Ser 
            180                 185                 190         


Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Ile Asp Tyr Asp 
        195                 200                 205             


His Pro Asp Val Gln Thr Glu Val Lys Asn Trp Gly Lys Trp Phe Val 
    210                 215                 220                 


Asn Thr Leu Asn Leu Asp Gly Val Arg Leu Asp Ala Val Lys His Ile 
225                 230                 235                 240 


Lys Phe Asp Tyr Met Ser Ser Trp Leu Ser Ser Val Lys Ser Thr Thr 
                245                 250                 255     


Gly Lys Ser Asn Leu Phe Ala Val Gly Glu Tyr Trp Asn Thr Ser Leu 
            260                 265                 270         


Gly Ala Leu Glu Asn Tyr Glu Asn Lys Thr Asn Trp Ser Met Ser Leu 
        275                 280                 285             


Phe Asp Val Pro Leu His Met Asn Phe Gln Ala Ala Ala Asn Gly Gly 
    290                 295                 300                 


Gly Tyr Tyr Asp Met Arg Asn Leu Leu Asn Asn Thr Met Met Lys Asn 
305                 310                 315                 320 


His Pro Ile Gln Ala Val Thr Phe Val Asp Asn His Asp Thr Glu Pro 
                325                 330                 335     


Gly Gln Ala Leu Gln Ser Trp Val Ser Asp Trp Phe Lys Pro Leu Ala 
            340                 345                 350         


Tyr Ala Thr Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr 
        355                 360                 365             


Gly Asp Tyr Tyr Gly Ile Pro Ser Gln Ser Val Ser Ala Lys Ser Thr 
    370                 375                 380                 


Trp Leu Asp Lys Gln Leu Ser Ala Arg Lys Ser Tyr Ala Tyr Gly Thr 
385                 390                 395                 400 


Gln His Asp Tyr Leu Asp Asn Gln Asp Val Ile Gly Trp Thr Arg Glu 
                405                 410                 415     


Gly Asp Ser Ala His Ala Gly Ser Gly Leu Ala Thr Val Met Ser Asp 
            420                 425                 430         


Gly Pro Gly Gly Ser Lys Thr Met Tyr Val Gly Thr Ala His Ala Gly 
        435                 440                 445             


Gln Val Phe Lys Asp Ile Thr Gly Asn Arg Thr Asp Thr Val Thr Ile 
    450                 455                 460                 


Asn Ser Ala Gly Asn Gly Thr Phe Pro Cys Asn Gly Gly Ser Val Ser 
465                 470                 475                 480 


Ile Trp Val Lys Gln 
                485 


<210>  130
<211>  485
<212>  PRT
<213>  Artifical Sequence

<400>  130

Thr Phe Ala Gly Asp Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr 
1               5                   10                  15      


Leu Pro Asn Asp Gly Thr Leu Trp Thr Lys Met Gly Ser Asp Ala Ser 
            20                  25                  30          


His Leu Lys Ser Ile Gly Ile Thr Gly Val Trp Phe Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Gln Ser Gln Ser Asp Val Gly Tyr Gly Val Tyr Asp Met Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Ala Gln Leu Gln Ser Ala Ile Thr Ser Leu His Asn Asn Gly 
                85                  90                  95      


Ile Gln Ala Tyr Gly Asp Val Val Leu Asp His Lys Gly Gly Ala Asp 
            100                 105                 110         


Gly Thr Glu Trp Val Asp Ala Val Glu Val Asn Pro Ser Asp Arg Asn 
        115                 120                 125             


Gln Glu Ile Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Val Asp Trp Asp Glu Ser Arg Lys Leu Ser Arg Ile 
                165                 170                 175     


Tyr Lys Phe Arg Gly Ile Gly Lys Ala Trp Asp Trp Glu Val Asp Thr 
            180                 185                 190         


Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Leu Asp Tyr Asp 
        195                 200                 205             


His Pro Asp Val Gln Thr Glu Val Lys Asn Trp Gly Lys Trp Phe Val 
    210                 215                 220                 


Asn Thr Leu Asn Leu Asp Gly Val Arg Leu Asp Ala Val Lys His Ile 
225                 230                 235                 240 


Lys Phe Asp Tyr Met Ser Ser Trp Leu Ser Ser Val Lys Ser Thr Thr 
                245                 250                 255     


Gly Lys Ser Asn Leu Phe Ala Val Gly Glu Tyr Trp Asn Thr Ser Leu 
            260                 265                 270         


Gly Ala Leu Glu Asn Tyr Glu Asn Lys Thr Asn Trp Ser Met Ser Leu 
        275                 280                 285             


Phe Asp Val Pro Leu His Met Asn Phe Gln Ala Ala Ala Asn Gly Gly 
    290                 295                 300                 


Gly Tyr Tyr Asp Met Arg Asn Leu Leu Asn Asn Thr Met Met Lys Asn 
305                 310                 315                 320 


His Pro Ile Gln Ala Val Thr Phe Val Asp Asn His Asp Thr Glu Pro 
                325                 330                 335     


Gly Gln Ala Leu Gln Ser Trp Val Ser Asp Trp Phe Lys Pro Leu Ala 
            340                 345                 350         


Tyr Ala Thr Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr 
        355                 360                 365             


Gly Asp Tyr Tyr Gly Ile Pro Ser Gln Ser Val Ser Ala Lys Ser Thr 
    370                 375                 380                 


Trp Leu Asp Lys Gln Leu Ser Ala Arg Lys Ser Tyr Ala Tyr Gly Thr 
385                 390                 395                 400 


Gln His Asp Tyr Leu Asp Asn Gln Asp Val Ile Gly Trp Thr Arg Glu 
                405                 410                 415     


Gly Asp Ser Ala His Ala Gly Ser Gly Leu Ala Thr Val Met Ser Asp 
            420                 425                 430         


Gly Pro Gly Gly Ser Lys Thr Met Tyr Val Gly Thr Ala His Ala Gly 
        435                 440                 445             


Gln Val Phe Lys Asp Ile Thr Gly Asn Arg Thr Asp Thr Val Thr Ile 
    450                 455                 460                 


Asn Ser Ala Gly Asn Gly Thr Phe Pro Cys Asn Gly Gly Ser Val Ser 
465                 470                 475                 480 


Ile Trp Val Lys Gln 
                485 


<210>  131
<211>  485
<212>  PRT
<213>  Artifical Sequence

<400>  131

Thr Phe Ala Gly Asp Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr 
1               5                   10                  15      


Leu Pro Asn Asp Gly Thr Leu Trp Thr Lys Met Gly Ser Asp Ala Ser 
            20                  25                  30          


His Leu Lys Ser Ile Gly Ile Thr Gly Val Trp Phe Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Gln Ser Gln Ser Asp Val Gly Tyr Gly Val Tyr Asp Met Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Ala Gln Leu Gln Ser Ala Ile Thr Ser Leu His Asn Asn Gly 
                85                  90                  95      


Ile Gln Ala Tyr Gly Asp Val Val Leu Asn His Lys Ala Gly Ala Asp 
            100                 105                 110         


Gly Thr Glu Leu Val Asp Ala Val Glu Val Asn Pro Ser Asp Arg Asn 
        115                 120                 125             


Gln Glu Ile Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Glu Ser Arg Lys Leu Asn Arg Ile 
                165                 170                 175     


Tyr Lys Phe Arg Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Asp Thr 
            180                 185                 190         


Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Leu Asp Tyr Asp 
        195                 200                 205             


His Pro Asp Val Gln Thr Glu Val Lys Asn Trp Gly Lys Trp Phe Val 
    210                 215                 220                 


Asn Thr Leu Asn Leu Asp Gly Val Arg Leu Asp Ala Val Lys His Ile 
225                 230                 235                 240 


Lys Phe Asp Tyr Met Ser Ser Trp Leu Ser Ser Val Lys Ser Thr Thr 
                245                 250                 255     


Gly Lys Ser Asn Leu Phe Ala Val Gly Glu Tyr Trp Asn Thr Ser Leu 
            260                 265                 270         


Gly Ala Leu Glu Asn Tyr Glu Asn Lys Thr Asn Trp Ser Met Ser Leu 
        275                 280                 285             


Phe Asp Val Pro Leu His Met Asn Phe Gln Ala Ala Ala Asn Gly Gly 
    290                 295                 300                 


Gly Tyr Tyr Asp Met Arg Asn Leu Leu Asn Asn Thr Met Met Lys Asn 
305                 310                 315                 320 


His Pro Ile Gln Ala Val Thr Phe Val Asp Asn His Asp Thr Glu Pro 
                325                 330                 335     


Gly Gln Ala Leu Gln Ser Trp Val Ser Asp Trp Phe Lys Pro Leu Ala 
            340                 345                 350         


Tyr Ala Thr Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr 
        355                 360                 365             


Gly Asp Tyr Tyr Gly Ile Pro Ser Gln Ser Val Ser Ala Lys Ser Thr 
    370                 375                 380                 


Trp Leu Asp Lys Gln Leu Ser Ala Arg Lys Ser Tyr Ala Tyr Gly Thr 
385                 390                 395                 400 


Gln His Asp Tyr Leu Asp Asn Gln Asp Val Ile Gly Trp Thr Arg Glu 
                405                 410                 415     


Gly Asp Ser Ala His Ala Gly Ser Gly Leu Ala Thr Val Met Ser Asp 
            420                 425                 430         


Gly Pro Gly Gly Ser Lys Thr Met Tyr Val Gly Thr Ala His Ala Gly 
        435                 440                 445             


Gln Val Phe Lys Asp Ile Thr Gly Asn Arg Thr Asp Thr Val Thr Ile 
    450                 455                 460                 


Asn Ser Ala Gly Asn Gly Thr Phe Pro Cys Asn Gly Gly Ser Val Ser 
465                 470                 475                 480 


Ile Trp Val Lys Gln 
                485 


<210>  132
<211>  485
<212>  PRT
<213>  Artifical Sequence

<400>  132

Thr Phe Ala Gly Asp Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr 
1               5                   10                  15      


Leu Pro Asn Asp Gly Thr Leu Trp Thr Lys Met Gly Ser Asp Ala Ser 
            20                  25                  30          


His Leu Lys Ser Ile Gly Ile Thr Gly Val Trp Phe Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Gln Ser Gln Ser Asp Val Gly Tyr Gly Val Tyr Asp Met Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Ala Gln Leu Gln Ser Ala Ile Thr Ser Leu His Asn Asn Gly 
                85                  90                  95      


Ile Gln Ala Tyr Gly Asp Val Val Leu Asn His Lys Ala Gly Ala Asp 
            100                 105                 110         


Gly Thr Glu Phe Val Asp Ala Val Glu Val Asn Pro Ser Asn Arg Asn 
        115                 120                 125             


Gln Glu Thr Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Glu Ser Arg Lys Leu Asn Arg Val 
                165                 170                 175     


Tyr Lys Phe Arg Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Asp Thr 
            180                 185                 190         


Glu Asn Gly Asn Tyr Asp Tyr Leu Met Phe Ala Asp Leu Asp Tyr Asp 
        195                 200                 205             


His Pro Asp Val Gln Thr Glu Val Lys Asn Trp Gly Lys Trp Phe Val 
    210                 215                 220                 


Asn Thr Leu Asn Leu Asp Gly Val Arg Leu Asp Ala Val Lys His Ile 
225                 230                 235                 240 


Lys Phe Asp Tyr Met Ser Ser Trp Leu Ser Ser Val Lys Ser Thr Thr 
                245                 250                 255     


Gly Lys Ser Asn Leu Phe Ala Val Gly Glu Tyr Trp Asn Thr Ser Leu 
            260                 265                 270         


Gly Ala Leu Glu Asn Tyr Glu Asn Lys Thr Asn Trp Ser Met Ser Leu 
        275                 280                 285             


Phe Asp Val Pro Leu His Met Asn Phe Gln Ala Ala Ala Asn Gly Gly 
    290                 295                 300                 


Gly Tyr Tyr Asp Met Arg Asn Leu Leu Asn Asn Thr Met Met Lys Asn 
305                 310                 315                 320 


His Pro Ile Gln Ala Val Thr Phe Val Asp Asn His Asp Thr Glu Pro 
                325                 330                 335     


Gly Gln Ala Leu Gln Ser Trp Val Ser Asp Trp Phe Lys Pro Leu Ala 
            340                 345                 350         


Tyr Ala Thr Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr 
        355                 360                 365             


Gly Asp Tyr Tyr Gly Ile Pro Ser Gln Ser Val Ser Ala Lys Ser Thr 
    370                 375                 380                 


Trp Leu Asp Lys Gln Leu Ser Ala Arg Lys Ser Tyr Ala Tyr Gly Thr 
385                 390                 395                 400 


Gln His Asp Tyr Leu Asp Asn Gln Asp Val Ile Gly Trp Thr Arg Glu 
                405                 410                 415     


Gly Asp Ser Ala His Ala Gly Ser Gly Leu Ala Thr Val Met Ser Asp 
            420                 425                 430         


Gly Pro Gly Gly Ser Lys Thr Met Tyr Val Gly Thr Ala His Ala Gly 
        435                 440                 445             


Gln Val Phe Lys Asp Ile Thr Gly Asn Arg Thr Asp Thr Val Thr Ile 
    450                 455                 460                 


Asn Ser Ala Gly Asn Gly Thr Phe Pro Cys Asn Gly Gly Ser Val Ser 
465                 470                 475                 480 


Ile Trp Val Lys Gln 
                485 


<210>  133
<211>  484
<212>  PRT
<213>  Artifical Sequence

<400>  133

Thr Phe Ala Gly Asp Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr 
1               5                   10                  15      


Leu Pro Asn Asp Gly Thr Leu Trp Thr Lys Met Gly Ser Asp Ala Ser 
            20                  25                  30          


His Leu Lys Ser Ile Gly Ile Thr Gly Val Trp Phe Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Gln Ser Gln Ser Asp Val Gly Tyr Gly Val Tyr Asp Met Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Ala Gln Leu Gln Ser Ala Ile Thr Ser Leu His Asn Asn Gly 
                85                  90                  95      


Ile Gln Ala Tyr Gly Asp Val Val Leu Asn His Lys Ala Gly Ala Asp 
            100                 105                 110         


Gly Thr Glu Phe Val Asp Ala Val Glu Val Asp Pro Ser Asn Arg Asn 
        115                 120                 125             


Gln Glu Thr Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Glu Ser Arg Lys Leu Asn Arg Ile 
                165                 170                 175     


Tyr Lys Phe Ser Thr Gly Lys Ala Trp Asp Trp Glu Val Asp Thr Glu 
            180                 185                 190         


Asn Gly Asn Tyr Asp Tyr Leu Met Phe Ala Asp Leu Asp Tyr Asp His 
        195                 200                 205             


Pro Asp Val Gln Thr Glu Val Lys Asn Trp Gly Lys Trp Phe Val Asn 
    210                 215                 220                 


Thr Leu Asn Leu Asp Gly Val Arg Leu Asp Ala Val Lys His Ile Lys 
225                 230                 235                 240 


Phe Asp Tyr Met Ser Ser Trp Leu Ser Ser Val Lys Ser Thr Thr Gly 
                245                 250                 255     


Lys Ser Asn Leu Phe Ala Val Gly Glu Tyr Trp Asn Thr Ser Leu Gly 
            260                 265                 270         


Ala Leu Glu Asn Tyr Glu Asn Lys Thr Asn Trp Ser Met Ser Leu Phe 
        275                 280                 285             


Asp Val Pro Leu His Met Asn Phe Gln Ala Ala Ala Asn Gly Gly Gly 
    290                 295                 300                 


Tyr Tyr Asp Met Arg Asn Leu Leu Asn Asn Thr Met Met Lys Asn His 
305                 310                 315                 320 


Pro Ile Gln Ala Val Thr Phe Val Asp Asn His Asp Thr Glu Pro Gly 
                325                 330                 335     


Gln Ala Leu Gln Ser Trp Val Ser Asp Trp Phe Lys Pro Leu Ala Tyr 
            340                 345                 350         


Ala Thr Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr Gly 
        355                 360                 365             


Asp Tyr Tyr Gly Ile Pro Ser Gln Ser Val Ser Ala Lys Ser Thr Trp 
    370                 375                 380                 


Leu Asp Lys Gln Leu Ser Ala Arg Lys Ser Tyr Ala Tyr Gly Thr Gln 
385                 390                 395                 400 


His Asp Tyr Leu Asp Asn Gln Asp Val Ile Gly Trp Thr Arg Glu Gly 
                405                 410                 415     


Asp Ser Ala His Ala Gly Ser Gly Leu Ala Thr Val Met Ser Asp Gly 
            420                 425                 430         


Pro Gly Gly Ser Lys Thr Met Tyr Val Gly Thr Ala His Ala Gly Gln 
        435                 440                 445             


Val Phe Lys Asp Ile Thr Gly Asn Arg Thr Asp Thr Val Thr Ile Asn 
    450                 455                 460                 


Ser Ala Gly Asn Gly Thr Phe Pro Cys Asn Gly Gly Ser Val Ser Ile 
465                 470                 475                 480 


Trp Val Lys Gln 
                


<210>  134
<211>  485
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sythetic Construct

<400>  134

Thr Phe Ala Gly Asp Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr 
1               5                   10                  15      


Leu Pro Asn Asp Gly Thr Leu Trp Thr Lys Met Gly Ser Asp Ala Ser 
            20                  25                  30          


His Leu Lys Ser Ile Gly Ile Thr Gly Val Trp Phe Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Gln Ser Gln Ser Asp Val Gly Tyr Gly Val Tyr Asp Met Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Ala Gln Leu Gln Ser Ala Ile Thr Ser Leu His Asn Asn Gly 
                85                  90                  95      


Ile Gln Ala Tyr Gly Asp Val Val Leu Asn His Lys Ala Gly Ala Asp 
            100                 105                 110         


Gly Thr Glu Phe Val Asp Ala Val Glu Val Asn Pro Ser Asn Arg Asn 
        115                 120                 125             


Gln Glu Thr Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Glu Ser Arg Lys Leu Asn Arg Ile 
                165                 170                 175     


Tyr Lys Phe Arg Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Asp Thr 
            180                 185                 190         


Glu Asn Gly Asn Tyr Asp Tyr Leu Met Phe Ala Asp Leu Asp Tyr Asp 
        195                 200                 205             


His Pro Asp Val Gln Thr Glu Val Lys Asn Trp Gly Lys Trp Phe Val 
    210                 215                 220                 


Asn Thr Leu Asn Leu Asp Gly Val Arg Leu Asp Ala Val Lys His Ile 
225                 230                 235                 240 


Lys Phe Asp Tyr Met Ser Ser Trp Leu Ser Ser Val Lys Ser Thr Thr 
                245                 250                 255     


Gly Lys Ser Asn Leu Phe Ala Val Gly Glu Tyr Trp Asn Thr Ser Leu 
            260                 265                 270         


Gly Ala Leu Glu Asn Tyr Glu Asn Lys Thr Asn Trp Ser Met Ser Leu 
        275                 280                 285             


Phe Asp Val Pro Leu His Met Asn Phe Gln Ala Ala Ala Asn Gly Gly 
    290                 295                 300                 


Gly Tyr Tyr Asp Met Arg Asn Leu Leu Asn Asn Thr Met Met Lys Asn 
305                 310                 315                 320 


His Pro Ile Gln Ala Val Thr Phe Val Asp Asn His Asp Thr Glu Pro 
                325                 330                 335     


Gly Gln Ala Leu Gln Ser Trp Val Ser Asp Trp Phe Lys Pro Leu Ala 
            340                 345                 350         


Tyr Ala Thr Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr 
        355                 360                 365             


Gly Asp Tyr Tyr Gly Ile Pro Ser Gln Ser Val Ser Ala Lys Ser Thr 
    370                 375                 380                 


Trp Leu Asp Lys Gln Leu Ser Ala Arg Lys Ser Tyr Ala Tyr Gly Thr 
385                 390                 395                 400 


Gln His Asp Tyr Leu Asp Asn Gln Asp Val Ile Gly Trp Thr Arg Glu 
                405                 410                 415     


Gly Asp Ser Ala His Ala Gly Ser Gly Leu Ala Thr Val Met Ser Asp 
            420                 425                 430         


Gly Pro Gly Gly Ser Lys Thr Met Tyr Val Gly Thr Ala His Ala Gly 
        435                 440                 445             


Gln Val Phe Lys Asp Ile Thr Gly Asn Arg Thr Asp Thr Val Thr Ile 
    450                 455                 460                 


Asn Ser Ala Gly Asn Gly Thr Phe Pro Cys Asn Gly Gly Ser Val Ser 
465                 470                 475                 480 


Ile Trp Val Lys Gln 
                485 


<210>  135
<211>  485
<212>  PRT
<213>  Artifical Sequence

<400>  135

Thr Phe Ala Gly Asp Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr 
1               5                   10                  15      


Leu Pro Asn Asp Gly Thr Leu Trp Thr Lys Met Gly Ser Asp Ala Ser 
            20                  25                  30          


His Leu Lys Ser Ile Gly Ile Thr Gly Val Trp Phe Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Gln Ser Gln Ser Asp Val Gly Tyr Gly Val Tyr Asp Met Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Ala Gln Leu Gln Ser Ala Ile Thr Ser Leu His Asn Asn Gly 
                85                  90                  95      


Ile Gln Ala Tyr Gly Asp Val Val Leu Asn His Lys Ala Gly Ala Asp 
            100                 105                 110         


Ala Thr Glu Trp Val Asp Ala Val Glu Val Asn Pro Ser Asn Arg Asn 
        115                 120                 125             


Gln Glu Val Ser Gly Thr Tyr Lys Ile Gln Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Gln Ser Arg Gln Leu Asn Arg Ile 
                165                 170                 175     


Tyr Lys Phe Arg Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Asp Thr 
            180                 185                 190         


Glu Asn Gly Asn Tyr Asp Tyr Leu Met Phe Ala Asp Leu Asp Tyr Asp 
        195                 200                 205             


His Pro Asp Val Gln Thr Glu Val Lys Asn Trp Gly Lys Trp Phe Val 
    210                 215                 220                 


Asn Thr Leu Asn Leu Asp Gly Val Arg Leu Asp Ala Val Lys His Ile 
225                 230                 235                 240 


Lys Phe Asp Tyr Met Ser Ser Trp Leu Ser Ser Val Lys Ser Thr Thr 
                245                 250                 255     


Gly Lys Ser Asn Leu Phe Ala Val Gly Glu Tyr Trp Asn Thr Ser Leu 
            260                 265                 270         


Gly Ala Leu Glu Asn Tyr Glu Asn Lys Thr Asn Trp Ser Met Ser Leu 
        275                 280                 285             


Phe Asp Val Pro Leu His Met Asn Phe Gln Ala Ala Ala Asn Gly Gly 
    290                 295                 300                 


Gly Tyr Tyr Asp Met Arg Asn Leu Leu Asn Asn Thr Met Met Lys Asn 
305                 310                 315                 320 


His Pro Ile Gln Ala Val Thr Phe Val Asp Asn His Asp Thr Glu Pro 
                325                 330                 335     


Gly Gln Ala Leu Gln Ser Trp Val Ser Asp Trp Phe Lys Pro Leu Ala 
            340                 345                 350         


Tyr Ala Thr Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr 
        355                 360                 365             


Gly Asp Tyr Tyr Gly Ile Pro Ser Gln Ser Val Ser Ala Lys Ser Thr 
    370                 375                 380                 


Trp Leu Asp Lys Gln Leu Ser Ala Arg Lys Ser Tyr Ala Tyr Gly Thr 
385                 390                 395                 400 


Gln His Asp Tyr Leu Asp Asn Gln Asp Val Ile Gly Trp Thr Arg Glu 
                405                 410                 415     


Gly Asp Ser Ala His Ala Gly Ser Gly Leu Ala Thr Val Met Ser Asp 
            420                 425                 430         


Gly Pro Gly Gly Ser Lys Thr Met Tyr Val Gly Thr Ala His Ala Gly 
        435                 440                 445             


Gln Val Phe Lys Asp Ile Thr Gly Asn Arg Thr Asp Thr Val Thr Ile 
    450                 455                 460                 


Asn Ser Ala Gly Asn Gly Thr Phe Pro Cys Asn Gly Gly Ser Val Ser 
465                 470                 475                 480 


Ile Trp Val Lys Gln 
                485 


<210>  136
<211>  485
<212>  PRT
<213>  Artifical Sequence

<400>  136

Thr Phe Ala Gly Asp Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr 
1               5                   10                  15      


Leu Pro Asn Asp Gly Thr Leu Trp Thr Lys Met Gly Ser Asp Ala Ser 
            20                  25                  30          


His Leu Lys Ser Ile Gly Ile Thr Gly Val Trp Phe Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Gln Ser Gln Ser Asp Val Gly Tyr Gly Val Tyr Asp Met Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Ala Gln Leu Gln Ser Ala Ile Thr Ser Leu His Asn Asn Gly 
                85                  90                  95      


Ile Gln Ala Tyr Gly Asp Val Val Leu Asn His Lys Ala Gly Ala Asp 
            100                 105                 110         


Ser Thr Glu Trp Val Asp Ala Val Glu Val Asn Pro Ser Asn Arg Asn 
        115                 120                 125             


Gln Glu Thr Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Glu Ser Arg Lys Leu Asn Arg Ile 
                165                 170                 175     


Tyr Lys Phe Arg Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Asp Thr 
            180                 185                 190         


Glu Asn Gly Asn Tyr Asp Tyr Leu Met Phe Ala Asp Leu Asp Tyr Asp 
        195                 200                 205             


His Pro Asp Val Gln Thr Glu Val Lys Asn Trp Gly Lys Trp Phe Val 
    210                 215                 220                 


Asn Thr Leu Asn Leu Asp Gly Val Arg Leu Asp Ala Val Lys His Ile 
225                 230                 235                 240 


Lys Phe Asp Tyr Met Ser Ser Trp Leu Ser Ser Val Lys Ser Thr Thr 
                245                 250                 255     


Gly Lys Ser Asn Leu Phe Ala Val Gly Glu Tyr Trp Asn Thr Ser Leu 
            260                 265                 270         


Gly Ala Leu Glu Asn Tyr Glu Asn Lys Thr Asn Trp Ser Met Ser Leu 
        275                 280                 285             


Phe Asp Val Pro Leu His Met Asn Phe Gln Ala Ala Ala Asn Gly Gly 
    290                 295                 300                 


Gly Tyr Tyr Asp Met Arg Asn Leu Leu Asn Asn Thr Met Met Lys Asn 
305                 310                 315                 320 


His Pro Ile Gln Ala Val Thr Phe Val Asp Asn His Asp Thr Glu Pro 
                325                 330                 335     


Gly Gln Ala Leu Gln Ser Trp Val Ser Asp Trp Phe Lys Pro Leu Ala 
            340                 345                 350         


Tyr Ala Thr Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr 
        355                 360                 365             


Gly Asp Tyr Tyr Gly Ile Pro Ser Gln Ser Val Ser Ala Lys Ser Thr 
    370                 375                 380                 


Trp Leu Asp Lys Gln Leu Ser Ala Arg Lys Ser Tyr Ala Tyr Gly Thr 
385                 390                 395                 400 


Gln His Asp Tyr Leu Asp Asn Gln Asp Val Ile Gly Trp Thr Arg Glu 
                405                 410                 415     


Gly Asp Ser Ala His Ala Gly Ser Gly Leu Ala Thr Val Met Ser Asp 
            420                 425                 430         


Gly Pro Gly Gly Ser Lys Thr Met Tyr Val Gly Thr Ala His Ala Gly 
        435                 440                 445             


Gln Val Phe Lys Asp Ile Thr Gly Asn Arg Thr Asp Thr Val Thr Ile 
    450                 455                 460                 


Asn Ser Ala Gly Asn Gly Thr Phe Pro Cys Asn Gly Gly Ser Val Ser 
465                 470                 475                 480 


Ile Trp Val Lys Gln 
                485 


<210>  137
<211>  486
<212>  PRT
<213>  Artifical Sequence

<400>  137

Thr Phe Ala Gly Asp Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr 
1               5                   10                  15      


Leu Pro Asn Asp Gly Thr Leu Trp Thr Lys Met Gly Ser Asp Ala Ser 
            20                  25                  30          


His Leu Lys Ser Ile Gly Ile Thr Gly Val Trp Phe Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Gln Ser Gln Ser Asp Val Gly Tyr Gly Val Tyr Asp Met Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Ala Gln Leu Gln Ser Ala Ile Thr Ser Leu His Asn Asn Gly 
                85                  90                  95      


Ile Gln Ala Tyr Gly Asp Val Val Leu Asn His Lys Gly Gly Ala Asp 
            100                 105                 110         


Phe Thr Glu Arg Val Gln Ala Val Glu Val Asn Pro Gln Asn Arg Asn 
        115                 120                 125             


Gln Glu Val Ser Gly Thr Tyr Gln Ile Glu Ala Trp Thr Gly Phe Asn 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Gln His Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Gln Ser Arg Gln Leu Ala Asn Arg 
                165                 170                 175     


Ile Tyr Lys Phe Arg Gly Asp Gly Lys Ala Trp Asp Trp Glu Val Asp 
            180                 185                 190         


Thr Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Val Asp Tyr 
        195                 200                 205             


Asp His Pro Asp Val Gln Thr Glu Val Lys Asn Trp Gly Lys Trp Phe 
    210                 215                 220                 


Val Asn Thr Leu Asn Leu Asp Gly Val Arg Leu Asp Ala Val Lys His 
225                 230                 235                 240 


Ile Lys Phe Asp Tyr Met Ser Ser Trp Leu Ser Ser Val Lys Ser Thr 
                245                 250                 255     


Thr Gly Lys Ser Asn Leu Phe Ala Val Gly Glu Tyr Trp Asn Thr Ser 
            260                 265                 270         


Leu Gly Ala Leu Glu Asn Tyr Glu Asn Lys Thr Asn Trp Ser Met Ser 
        275                 280                 285             


Leu Phe Asp Val Pro Leu His Met Asn Phe Gln Ala Ala Ala Asn Gly 
    290                 295                 300                 


Gly Gly Tyr Tyr Asp Met Arg Asn Leu Leu Asn Asn Thr Met Met Lys 
305                 310                 315                 320 


Asn His Pro Ile Gln Ala Val Thr Phe Val Asp Asn His Asp Thr Glu 
                325                 330                 335     


Pro Gly Gln Ala Leu Gln Ser Trp Val Ser Asp Trp Phe Lys Pro Leu 
            340                 345                 350         


Ala Tyr Ala Thr Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe 
        355                 360                 365             


Tyr Gly Asp Tyr Tyr Gly Ile Pro Ser Gln Ser Val Ser Ala Lys Ser 
    370                 375                 380                 


Thr Trp Leu Asp Lys Gln Leu Ser Ala Arg Lys Ser Tyr Ala Tyr Gly 
385                 390                 395                 400 


Thr Gln His Asp Tyr Leu Asp Asn Gln Asp Val Ile Gly Trp Thr Arg 
                405                 410                 415     


Glu Gly Asp Ser Ala His Ala Gly Ser Gly Leu Ala Thr Val Met Ser 
            420                 425                 430         


Asp Gly Pro Gly Gly Ser Lys Thr Met Tyr Val Gly Thr Ala His Ala 
        435                 440                 445             


Gly Gln Val Phe Lys Asp Ile Thr Gly Asn Arg Thr Asp Thr Val Thr 
    450                 455                 460                 


Ile Asn Ser Ala Gly Asn Gly Thr Phe Pro Cys Asn Gly Gly Ser Val 
465                 470                 475                 480 


Ser Ile Trp Val Lys Gln 
                485     


<210>  138
<211>  486
<212>  PRT
<213>  Artifical Sequence

<400>  138

Thr Phe Ala Gly Asp Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr 
1               5                   10                  15      


Leu Pro Asn Asp Gly Thr Leu Trp Thr Lys Met Gly Ser Asp Ala Ser 
            20                  25                  30          


His Leu Lys Ser Ile Gly Ile Thr Gly Val Trp Phe Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Gln Ser Gln Ser Asp Val Gly Tyr Gly Val Tyr Asp Met Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Ala Gln Leu Gln Ser Ala Ile Thr Ser Leu His Asn Asn Gly 
                85                  90                  95      


Ile Gln Ala Tyr Gly Asp Val Val Leu Asn His Lys Gly Gly Ala Asp 
            100                 105                 110         


Ala Thr Glu Asn Val Leu Ala Val Glu Val Asn Pro Asn Asn Arg Asn 
        115                 120                 125             


Gln Glu Ile Ser Gly Asp Tyr Thr Ile Glu Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Asp Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Val Asp Trp Asp Gln Ser Arg Gln Phe Gln Asn Arg 
                165                 170                 175     


Ile Tyr Lys Phe Arg Gly Asp Gly Lys Ala Trp Asp Trp Glu Val Asp 
            180                 185                 190         


Ser Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Val Asp Tyr 
        195                 200                 205             


Asp His Pro Asp Val Gln Thr Glu Val Lys Asn Trp Gly Lys Trp Phe 
    210                 215                 220                 


Val Asn Thr Leu Asn Leu Asp Gly Val Arg Leu Asp Ala Val Lys His 
225                 230                 235                 240 


Ile Lys Phe Asp Tyr Met Ser Ser Trp Leu Ser Ser Val Lys Ser Thr 
                245                 250                 255     


Thr Gly Lys Ser Asn Leu Phe Ala Val Gly Glu Tyr Trp Asn Thr Ser 
            260                 265                 270         


Leu Gly Ala Leu Glu Asn Tyr Glu Asn Lys Thr Asn Trp Ser Met Ser 
        275                 280                 285             


Leu Phe Asp Val Pro Leu His Met Asn Phe Gln Ala Ala Ala Asn Gly 
    290                 295                 300                 


Gly Gly Tyr Tyr Asp Met Arg Asn Leu Leu Asn Asn Thr Met Met Lys 
305                 310                 315                 320 


Asn His Pro Ile Gln Ala Val Thr Phe Val Asp Asn His Asp Thr Glu 
                325                 330                 335     


Pro Gly Gln Ala Leu Gln Ser Trp Val Ser Asp Trp Phe Lys Pro Leu 
            340                 345                 350         


Ala Tyr Ala Thr Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe 
        355                 360                 365             


Tyr Gly Asp Tyr Tyr Gly Ile Pro Ser Gln Ser Val Ser Ala Lys Ser 
    370                 375                 380                 


Thr Trp Leu Asp Lys Gln Leu Ser Ala Arg Lys Ser Tyr Ala Tyr Gly 
385                 390                 395                 400 


Thr Gln His Asp Tyr Leu Asp Asn Gln Asp Val Ile Gly Trp Thr Arg 
                405                 410                 415     


Glu Gly Asp Ser Ala His Ala Gly Ser Gly Leu Ala Thr Val Met Ser 
            420                 425                 430         


Asp Gly Pro Gly Gly Ser Lys Thr Met Tyr Val Gly Thr Ala His Ala 
        435                 440                 445             


Gly Gln Val Phe Lys Asp Ile Thr Gly Asn Arg Thr Asp Thr Val Thr 
    450                 455                 460                 


Ile Asn Ser Ala Gly Asn Gly Thr Phe Pro Cys Asn Gly Gly Ser Val 
465                 470                 475                 480 


Ser Ile Trp Val Lys Gln 
                485     


<210>  139
<211>  486
<212>  PRT
<213>  Artifical Sequence

<400>  139

Thr Phe Ala Gly Asp Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr 
1               5                   10                  15      


Leu Pro Asn Asp Gly Thr Leu Trp Thr Lys Met Gly Ser Asp Ala Ser 
            20                  25                  30          


His Leu Lys Ser Ile Gly Ile Thr Gly Val Trp Phe Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Gln Ser Gln Ser Asp Val Gly Tyr Gly Val Tyr Asp Met Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Ala Gln Leu Gln Ser Ala Ile Thr Ser Leu His Asn Asn Gly 
                85                  90                  95      


Ile Gln Ala Tyr Gly Asp Val Val Leu Asn His Lys Gly Gly Ala Asp 
            100                 105                 110         


Ala Thr Glu Met Val Arg Ala Val Glu Val Asn Pro Asn Asn Arg Asn 
        115                 120                 125             


Gln Glu Val Ser Gly Glu Tyr Thr Ile Glu Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr His Ser Asn Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Val Asp Trp Asp Gln Ser Arg Lys Leu Asn Asn Arg 
                165                 170                 175     


Ile Tyr Lys Phe Arg Gly Asp Gly Lys Gly Trp Asp Trp Glu Val Asp 
            180                 185                 190         


Thr Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Ile Asp Tyr 
        195                 200                 205             


Asp His Pro Asp Val Gln Thr Glu Val Lys Asn Trp Gly Lys Trp Phe 
    210                 215                 220                 


Val Asn Thr Leu Asn Leu Asp Gly Val Arg Leu Asp Ala Val Lys His 
225                 230                 235                 240 


Ile Lys Phe Asp Tyr Met Ser Ser Trp Leu Ser Ser Val Lys Ser Thr 
                245                 250                 255     


Thr Gly Lys Ser Asn Leu Phe Ala Val Gly Glu Tyr Trp Asn Thr Ser 
            260                 265                 270         


Leu Gly Ala Leu Glu Asn Tyr Glu Asn Lys Thr Asn Trp Ser Met Ser 
        275                 280                 285             


Leu Phe Asp Val Pro Leu His Met Asn Phe Gln Ala Ala Ala Asn Gly 
    290                 295                 300                 


Gly Gly Tyr Tyr Asp Met Arg Asn Leu Leu Asn Asn Thr Met Met Lys 
305                 310                 315                 320 


Asn His Pro Ile Gln Ala Val Thr Phe Val Asp Asn His Asp Thr Glu 
                325                 330                 335     


Pro Gly Gln Ala Leu Gln Ser Trp Val Ser Asp Trp Phe Lys Pro Leu 
            340                 345                 350         


Ala Tyr Ala Thr Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe 
        355                 360                 365             


Tyr Gly Asp Tyr Tyr Gly Ile Pro Ser Gln Ser Val Ser Ala Lys Ser 
    370                 375                 380                 


Thr Trp Leu Asp Lys Gln Leu Ser Ala Arg Lys Ser Tyr Ala Tyr Gly 
385                 390                 395                 400 


Thr Gln His Asp Tyr Leu Asp Asn Gln Asp Val Ile Gly Trp Thr Arg 
                405                 410                 415     


Glu Gly Asp Ser Ala His Ala Gly Ser Gly Leu Ala Thr Val Met Ser 
            420                 425                 430         


Asp Gly Pro Gly Gly Ser Lys Thr Met Tyr Val Gly Thr Ala His Ala 
        435                 440                 445             


Gly Gln Val Phe Lys Asp Ile Thr Gly Asn Arg Thr Asp Thr Val Thr 
    450                 455                 460                 


Ile Asn Ser Ala Gly Asn Gly Thr Phe Pro Cys Asn Gly Gly Ser Val 
465                 470                 475                 480 


Ser Ile Trp Val Lys Gln 
                485     


<210>  140
<211>  486
<212>  PRT
<213>  Artifical Sequence

<400>  140

Thr Phe Ala Gly Asp Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr 
1               5                   10                  15      


Leu Pro Asn Asp Gly Thr Leu Trp Thr Lys Met Gly Ser Asp Ala Ser 
            20                  25                  30          


His Leu Lys Ser Ile Gly Ile Thr Gly Val Trp Phe Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Gln Ser Gln Ser Asp Val Gly Tyr Gly Val Tyr Asp Met Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Ala Gln Leu Gln Ser Ala Ile Thr Ser Leu His Asn Asn Gly 
                85                  90                  95      


Ile Gln Ala Tyr Gly Asp Val Val Leu Asn His Lys Gly Gly Ala Asp 
            100                 105                 110         


Ala Thr Glu Met Val Arg Ala Val Glu Val Asn Pro Asn Asn Arg Asn 
        115                 120                 125             


Gln Glu Val Thr Gly Glu Tyr Thr Ile Glu Ala Trp Thr Arg Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr His Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Val Asp Trp Asp Gln Ser Arg Arg Leu Asn Asn Arg 
                165                 170                 175     


Ile Tyr Lys Phe Arg Gly His Gly Lys Ala Trp Asp Trp Glu Val Asp 
            180                 185                 190         


Thr Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Ile Asp Tyr 
        195                 200                 205             


Asp His Pro Asp Val Gln Thr Glu Val Lys Asn Trp Gly Lys Trp Phe 
    210                 215                 220                 


Val Asn Thr Leu Asn Leu Asp Gly Val Arg Leu Asp Ala Val Lys His 
225                 230                 235                 240 


Ile Lys Phe Asp Tyr Met Ser Ser Trp Leu Ser Ser Val Lys Ser Thr 
                245                 250                 255     


Thr Gly Lys Ser Asn Leu Phe Ala Val Gly Glu Tyr Trp Asn Thr Ser 
            260                 265                 270         


Leu Gly Ala Leu Glu Asn Tyr Glu Asn Lys Thr Asn Trp Ser Met Ser 
        275                 280                 285             


Leu Phe Asp Val Pro Leu His Met Asn Phe Gln Ala Ala Ala Asn Gly 
    290                 295                 300                 


Gly Gly Tyr Tyr Asp Met Arg Asn Leu Leu Asn Asn Thr Met Met Lys 
305                 310                 315                 320 


Asn His Pro Ile Gln Ala Val Thr Phe Val Asp Asn His Asp Thr Glu 
                325                 330                 335     


Pro Gly Gln Ala Leu Gln Ser Trp Val Ser Asp Trp Phe Lys Pro Leu 
            340                 345                 350         


Ala Tyr Ala Thr Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe 
        355                 360                 365             


Tyr Gly Asp Tyr Tyr Gly Ile Pro Ser Gln Ser Val Ser Ala Lys Ser 
    370                 375                 380                 


Thr Trp Leu Asp Lys Gln Leu Ser Ala Arg Lys Ser Tyr Ala Tyr Gly 
385                 390                 395                 400 


Thr Gln His Asp Tyr Leu Asp Asn Gln Asp Val Ile Gly Trp Thr Arg 
                405                 410                 415     


Glu Gly Asp Ser Ala His Ala Gly Ser Gly Leu Ala Thr Val Met Ser 
            420                 425                 430         


Asp Gly Pro Gly Gly Ser Lys Thr Met Tyr Val Gly Thr Ala His Ala 
        435                 440                 445             


Gly Gln Val Phe Lys Asp Ile Thr Gly Asn Arg Thr Asp Thr Val Thr 
    450                 455                 460                 


Ile Asn Ser Ala Gly Asn Gly Thr Phe Pro Cys Asn Gly Gly Ser Val 
465                 470                 475                 480 


Ser Ile Trp Val Lys Gln 
                485     


<210>  141
<211>  486
<212>  PRT
<213>  Artifical Sequence

<400>  141

Ala Ala Thr Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr Val Pro 
1               5                   10                  15      


Asn Asp Gly Gln Gln Trp Asn Arg Leu Arg Thr Asp Ala Pro Tyr Leu 
            20                  25                  30          


Ser Ser Val Gly Ile Thr Ala Val Trp Thr Pro Pro Ala Tyr Lys Gly 
        35                  40                  45              


Thr Ser Gln Ala Asp Val Gly Tyr Gly Pro Tyr Asp Leu Tyr Asp Leu 
    50                  55                  60                  


Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly Thr Lys 
65                  70                  75                  80  


Gly Glu Leu Lys Ser Ala Val Asn Thr Leu His Ser Asn Gly Ile Gln 
                85                  90                  95      


Val Tyr Gly Asp Val Val Met Asn His Arg Met Gly Ala Asp Ala Thr 
            100                 105                 110         


Glu Thr Ile Ser Ala Val Glu Val Asn Pro Ser Asn Arg Asn Gln Val 
        115                 120                 125             


Thr Ser Gly Ala Tyr Asn Ile Ser Ala Trp Thr Asp Phe Glu Phe Pro 
    130                 135                 140                 


Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp His Ser Tyr Tyr Phe 
145                 150                 155                 160 


Asp Gly Val Asp Trp Asp Gln Ser Arg Gln Leu Ser Gly Lys Ile Tyr 
                165                 170                 175     


Gln Ile Gln Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Asp Ser Glu 
            180                 185                 190         


Asn Gly Asn Tyr Asp Tyr Leu Met Gly Ala Asp Ile Asp Tyr Asp His 
        195                 200                 205             


Pro Asp Val Val Asn Glu Met Lys Lys Trp Gly Val Trp Tyr Ala Asn 
    210                 215                 220                 


Glu Val Gly Leu Asp Gly Tyr Arg Leu Asp Ala Val Lys His Ile Lys 
225                 230                 235                 240 


Phe Ser Phe Leu Lys Asp Trp Val Asp Asn Ala Arg Ala Ala Thr Gly 
                245                 250                 255     


Lys Glu Met Phe Thr Val Gly Glu Tyr Trp Gln Asn Asp Leu Gly Ala 
            260                 265                 270         


Leu Asn Asn Tyr Leu Ala Lys Val Asn Tyr Asn Gln Ser Leu Phe Asp 
        275                 280                 285             


Ala Pro Leu His Tyr Asn Phe Tyr Ala Ala Ser Thr Gly Gly Gly Tyr 
    290                 295                 300                 


Tyr Asp Met Arg Asn Ile Leu Asn Asn Thr Leu Val Ala Ser Asn Pro 
305                 310                 315                 320 


Thr Lys Ala Val Thr Leu Val Glu Asn His Asp Thr Gln Pro Gly Gln 
                325                 330                 335     


Ser Leu Glu Ser Thr Val Gln Pro Trp Phe Lys Pro Leu Ala Tyr Ala 
            340                 345                 350         


Phe Ile Leu Thr Arg Ser Gly Gly Tyr Pro Ser Val Phe Tyr Gly Asp 
        355                 360                 365             


Met Tyr Gly Thr Lys Gly Thr Thr Thr Arg Glu Ile Pro Ala Leu Lys 
    370                 375                 380                 


Ser Lys Ile Glu Pro Leu Leu Lys Ala Arg Lys Asp Tyr Ala Tyr Gly 
385                 390                 395                 400 


Thr Gln Arg Asp Tyr Ile Asp Asn Pro Asp Val Ile Gly Trp Thr Arg 
                405                 410                 415     


Glu Gly Asp Ser Thr Lys Ala Lys Ser Gly Leu Ala Thr Val Ile Thr 
            420                 425                 430         


Asp Gly Pro Gly Gly Ser Lys Arg Met Tyr Val Gly Thr Ser Asn Ala 
        435                 440                 445             


Gly Glu Ile Trp Tyr Asp Leu Thr Gly Asn Arg Thr Asp Lys Ile Thr 
    450                 455                 460                 


Ile Gly Ser Asp Gly Tyr Ala Thr Phe Pro Val Asn Gly Gly Ser Val 
465                 470                 475                 480 


Ser Val Trp Val Gln Gln 
                485     


<210>  142
<211>  485
<212>  PRT
<213>  Artifical Sequence

<400>  142

Ala Ala Thr Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr Val Pro 
1               5                   10                  15      


Asn Asp Gly Gln Gln Trp Asn Arg Leu Arg Thr Asp Ala Pro Tyr Leu 
            20                  25                  30          


Ser Ser Val Gly Ile Thr Ala Val Trp Thr Pro Pro Ala Tyr Lys Gly 
        35                  40                  45              


Thr Ser Gln Ala Asp Val Gly Tyr Gly Pro Tyr Asp Leu Tyr Asp Leu 
    50                  55                  60                  


Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly Thr Lys 
65                  70                  75                  80  


Gly Glu Leu Lys Ser Ala Val Asn Thr Leu His Ser Asn Gly Ile Gln 
                85                  90                  95      


Val Tyr Gly Asp Val Val Met Asn His Lys Ala Gly Ala Asp Ala Thr 
            100                 105                 110         


Glu Asp Val Thr Ala Val Glu Val Asn Pro Ala Asn Arg Asn Gln Glu 
        115                 120                 125             


Thr Ser Glu Glu Tyr Gln Ile Lys Ala Trp Thr Asp Phe Arg Phe Pro 
    130                 135                 140                 


Gly Arg Gly Asn Thr Tyr Ser Asp Phe Lys Trp His Trp Tyr His Phe 
145                 150                 155                 160 


Asp Gly Ala Asp Trp Asp Glu Ser Arg Lys Ile Ser Arg Ile Phe Lys 
                165                 170                 175     


Phe Arg Gly Glu Gly Lys Ala Trp Asp Trp Glu Val Ser Ser Glu Asn 
            180                 185                 190         


Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Val Asp Tyr Asp His Pro 
        195                 200                 205             


Asp Val Val Asn Glu Met Lys Lys Trp Gly Val Trp Tyr Ala Asn Glu 
    210                 215                 220                 


Val Gly Leu Asp Gly Tyr Arg Leu Asp Ala Val Lys His Ile Lys Phe 
225                 230                 235                 240 


Ser Phe Leu Lys Asp Trp Val Asp Asn Ala Arg Ala Ala Thr Gly Lys 
                245                 250                 255     


Glu Met Phe Thr Val Gly Glu Tyr Trp Gln Asn Asp Leu Gly Ala Leu 
            260                 265                 270         


Asn Asn Tyr Leu Ala Lys Val Asn Tyr Asn Gln Ser Leu Phe Asp Ala 
        275                 280                 285             


Pro Leu His Tyr Asn Phe Tyr Ala Ala Ser Thr Gly Gly Gly Tyr Tyr 
    290                 295                 300                 


Asp Met Arg Asn Ile Leu Asn Asn Thr Leu Val Ala Ser Asn Pro Thr 
305                 310                 315                 320 


Lys Ala Val Thr Leu Val Glu Asn His Asp Thr Gln Pro Gly Gln Ser 
                325                 330                 335     


Leu Glu Ser Thr Val Gln Pro Trp Phe Lys Pro Leu Ala Tyr Ala Phe 
            340                 345                 350         


Ile Leu Thr Arg Ser Gly Gly Tyr Pro Ser Val Phe Tyr Gly Asp Met 
        355                 360                 365             


Tyr Gly Thr Lys Gly Thr Thr Thr Arg Glu Ile Pro Ala Leu Lys Ser 
    370                 375                 380                 


Lys Ile Glu Pro Leu Leu Lys Ala Arg Lys Asp Tyr Ala Tyr Gly Thr 
385                 390                 395                 400 


Gln Arg Asp Tyr Ile Asp Asn Pro Asp Val Ile Gly Trp Thr Arg Glu 
                405                 410                 415     


Gly Asp Ser Thr Lys Ala Lys Ser Gly Leu Ala Thr Val Ile Thr Asp 
            420                 425                 430         


Gly Pro Gly Gly Ser Lys Arg Met Tyr Val Gly Thr Ser Asn Ala Gly 
        435                 440                 445             


Glu Ile Trp Tyr Asp Leu Thr Gly Asn Arg Thr Asp Lys Ile Thr Ile 
    450                 455                 460                 


Gly Ser Asp Gly Tyr Ala Thr Phe Pro Val Asn Gly Gly Ser Val Ser 
465                 470                 475                 480 


Val Trp Val Gln Gln 
                485 


<210>  143
<211>  483
<212>  PRT
<213>  Artifical Sequence

<400>  143

Ala Ala Thr Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr Val Pro 
1               5                   10                  15      


Asn Asp Gly Gln Gln Trp Asn Arg Leu Arg Thr Asp Ala Pro Tyr Leu 
            20                  25                  30          


Ser Ser Val Gly Ile Thr Ala Val Trp Thr Pro Pro Ala Tyr Lys Gly 
        35                  40                  45              


Thr Ser Gln Ala Asp Val Gly Tyr Gly Pro Tyr Asp Leu Tyr Asp Leu 
    50                  55                  60                  


Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly Thr Lys 
65                  70                  75                  80  


Gly Glu Leu Lys Ser Ala Val Asn Thr Leu His Ser Asn Gly Ile Gln 
                85                  90                  95      


Val Tyr Gly Asp Val Val Met Asn His Lys Gly Gly Ala Asp Ala Thr 
            100                 105                 110         


Glu Asp Val Thr Ala Val Glu Val Asp Pro Ala Asp Arg Asn Arg Val 
        115                 120                 125             


Ile Ser Gly Glu His Leu Ile Lys Ala Trp Thr His Phe His Phe Pro 
    130                 135                 140                 


Gly Arg Gly Ser Thr Tyr Ser Asp Phe Lys Trp His Trp Tyr His Phe 
145                 150                 155                 160 


Asp Gly Thr Asp Trp Asp Glu Ser Arg Lys Leu Asn Arg Ile Tyr Lys 
                165                 170                 175     


Phe Gln Gly Lys Ala Trp Asp Trp Glu Val Ser Asn Glu Phe Gly Asn 
            180                 185                 190         


Tyr Asp Tyr Leu Met Tyr Ala Asp Ile Asp Tyr Asp His Pro Asp Val 
        195                 200                 205             


Val Asn Glu Met Lys Lys Trp Gly Val Trp Tyr Ala Asn Glu Val Gly 
    210                 215                 220                 


Leu Asp Gly Tyr Arg Leu Asp Ala Val Lys His Ile Lys Phe Ser Phe 
225                 230                 235                 240 


Leu Lys Asp Trp Val Asp Asn Ala Arg Ala Ala Thr Gly Lys Glu Met 
                245                 250                 255     


Phe Thr Val Gly Glu Tyr Trp Gln Asn Asp Leu Gly Ala Leu Asn Asn 
            260                 265                 270         


Tyr Leu Ala Lys Val Asn Tyr Asn Gln Ser Leu Phe Asp Ala Pro Leu 
        275                 280                 285             


His Tyr Asn Phe Tyr Ala Ala Ser Thr Gly Gly Gly Tyr Tyr Asp Met 
    290                 295                 300                 


Arg Asn Ile Leu Asn Asn Thr Leu Val Ala Ser Asn Pro Thr Lys Ala 
305                 310                 315                 320 


Val Thr Leu Val Glu Asn His Asp Thr Gln Pro Gly Gln Ser Leu Glu 
                325                 330                 335     


Ser Thr Val Gln Pro Trp Phe Lys Pro Leu Ala Tyr Ala Phe Ile Leu 
            340                 345                 350         


Thr Arg Ser Gly Gly Tyr Pro Ser Val Phe Tyr Gly Asp Met Tyr Gly 
        355                 360                 365             


Thr Lys Gly Thr Thr Thr Arg Glu Ile Pro Ala Leu Lys Ser Lys Ile 
    370                 375                 380                 


Glu Pro Leu Leu Lys Ala Arg Lys Asp Tyr Ala Tyr Gly Thr Gln Arg 
385                 390                 395                 400 


Asp Tyr Ile Asp Asn Pro Asp Val Ile Gly Trp Thr Arg Glu Gly Asp 
                405                 410                 415     


Ser Thr Lys Ala Lys Ser Gly Leu Ala Thr Val Ile Thr Asp Gly Pro 
            420                 425                 430         


Gly Gly Ser Lys Arg Met Tyr Val Gly Thr Ser Asn Ala Gly Glu Ile 
        435                 440                 445             


Trp Tyr Asp Leu Thr Gly Asn Arg Thr Asp Lys Ile Thr Ile Gly Ser 
    450                 455                 460                 


Asp Gly Tyr Ala Thr Phe Pro Val Asn Gly Gly Ser Val Ser Val Trp 
465                 470                 475                 480 


Val Gln Gln 
            


<210>  144
<211>  485
<212>  PRT
<213>  Artifical Sequence

<400>  144

Ala Ala Thr Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr Val Pro 
1               5                   10                  15      


Asn Asp Gly Gln Gln Trp Asn Arg Leu Arg Thr Asp Ala Pro Tyr Leu 
            20                  25                  30          


Ser Ser Val Gly Ile Thr Ala Val Trp Thr Pro Pro Ala Tyr Lys Gly 
        35                  40                  45              


Thr Ser Gln Ala Asp Val Gly Tyr Gly Pro Tyr Asp Leu Tyr Asp Leu 
    50                  55                  60                  


Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly Thr Lys 
65                  70                  75                  80  


Gly Glu Leu Lys Ser Ala Val Asn Thr Leu His Ser Asn Gly Ile Gln 
                85                  90                  95      


Val Tyr Gly Asp Val Val Met Asp His Lys Gly Gly Ala Asp Gly Thr 
            100                 105                 110         


Glu Trp Val Asp Ala Val Glu Val Asn Pro Ser Asp Arg Asn Gln Glu 
        115                 120                 125             


Ile Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp Phe Pro 
    130                 135                 140                 


Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr His Phe 
145                 150                 155                 160 


Asp Gly Val Asp Trp Asp Glu Ser Arg Lys Leu Ser Arg Ile Tyr Lys 
                165                 170                 175     


Phe Arg Gly Ile Gly Lys Ala Trp Asp Trp Glu Val Asp Thr Glu Asn 
            180                 185                 190         


Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Leu Asp Tyr Asp His Pro 
        195                 200                 205             


Asp Val Val Asn Glu Met Lys Lys Trp Gly Val Trp Tyr Ala Asn Glu 
    210                 215                 220                 


Val Gly Leu Asp Gly Tyr Arg Leu Asp Ala Val Lys His Ile Lys Phe 
225                 230                 235                 240 


Ser Phe Leu Lys Asp Trp Val Asp Asn Ala Arg Ala Ala Thr Gly Lys 
                245                 250                 255     


Glu Met Phe Thr Val Gly Glu Tyr Trp Gln Asn Asp Leu Gly Ala Leu 
            260                 265                 270         


Asn Asn Tyr Leu Ala Lys Val Asn Tyr Asn Gln Ser Leu Phe Asp Ala 
        275                 280                 285             


Pro Leu His Tyr Asn Phe Tyr Ala Ala Ser Thr Gly Gly Gly Tyr Tyr 
    290                 295                 300                 


Asp Met Arg Asn Ile Leu Asn Asn Thr Leu Val Ala Ser Asn Pro Thr 
305                 310                 315                 320 


Lys Ala Val Thr Leu Val Glu Asn His Asp Thr Gln Pro Gly Gln Ser 
                325                 330                 335     


Leu Glu Ser Thr Val Gln Pro Trp Phe Lys Pro Leu Ala Tyr Ala Phe 
            340                 345                 350         


Ile Leu Thr Arg Ser Gly Gly Tyr Pro Ser Val Phe Tyr Gly Asp Met 
        355                 360                 365             


Tyr Gly Thr Lys Gly Thr Thr Thr Arg Glu Ile Pro Ala Leu Lys Ser 
    370                 375                 380                 


Lys Ile Glu Pro Leu Leu Lys Ala Arg Lys Asp Tyr Ala Tyr Gly Thr 
385                 390                 395                 400 


Gln Arg Asp Tyr Ile Asp Asn Pro Asp Val Ile Gly Trp Thr Arg Glu 
                405                 410                 415     


Gly Asp Ser Thr Lys Ala Lys Ser Gly Leu Ala Thr Val Ile Thr Asp 
            420                 425                 430         


Gly Pro Gly Gly Ser Lys Arg Met Tyr Val Gly Thr Ser Asn Ala Gly 
        435                 440                 445             


Glu Ile Trp Tyr Asp Leu Thr Gly Asn Arg Thr Asp Lys Ile Thr Ile 
    450                 455                 460                 


Gly Ser Asp Gly Tyr Ala Thr Phe Pro Val Asn Gly Gly Ser Val Ser 
465                 470                 475                 480 


Val Trp Val Gln Gln 
                485 


<210>  145
<211>  485
<212>  PRT
<213>  Artifical Sequence

<400>  145

Ala Ala Thr Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr Val Pro 
1               5                   10                  15      


Asn Asp Gly Gln Gln Trp Asn Arg Leu Arg Thr Asp Ala Pro Tyr Leu 
            20                  25                  30          


Ser Ser Val Gly Ile Thr Ala Val Trp Thr Pro Pro Ala Tyr Lys Gly 
        35                  40                  45              


Thr Ser Gln Ala Asp Val Gly Tyr Gly Pro Tyr Asp Leu Tyr Asp Leu 
    50                  55                  60                  


Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly Thr Lys 
65                  70                  75                  80  


Gly Glu Leu Lys Ser Ala Val Asn Thr Leu His Ser Asn Gly Ile Gln 
                85                  90                  95      


Val Tyr Gly Asp Val Val Met Asn His Lys Ala Gly Ala Asp Gly Thr 
            100                 105                 110         


Glu Leu Val Asp Ala Val Glu Val Asn Pro Ser Asp Arg Asn Gln Glu 
        115                 120                 125             


Ile Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp Phe Pro 
    130                 135                 140                 


Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr His Phe 
145                 150                 155                 160 


Asp Gly Thr Asp Trp Asp Glu Ser Arg Lys Leu Asn Arg Ile Tyr Lys 
                165                 170                 175     


Phe Arg Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Asp Thr Glu Asn 
            180                 185                 190         


Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Leu Asp Tyr Asp His Pro 
        195                 200                 205             


Asp Val Val Asn Glu Met Lys Lys Trp Gly Val Trp Tyr Ala Asn Glu 
    210                 215                 220                 


Val Gly Leu Asp Gly Tyr Arg Leu Asp Ala Val Lys His Ile Lys Phe 
225                 230                 235                 240 


Ser Phe Leu Lys Asp Trp Val Asp Asn Ala Arg Ala Ala Thr Gly Lys 
                245                 250                 255     


Glu Met Phe Thr Val Gly Glu Tyr Trp Gln Asn Asp Leu Gly Ala Leu 
            260                 265                 270         


Asn Asn Tyr Leu Ala Lys Val Asn Tyr Asn Gln Ser Leu Phe Asp Ala 
        275                 280                 285             


Pro Leu His Tyr Asn Phe Tyr Ala Ala Ser Thr Gly Gly Gly Tyr Tyr 
    290                 295                 300                 


Asp Met Arg Asn Ile Leu Asn Asn Thr Leu Val Ala Ser Asn Pro Thr 
305                 310                 315                 320 


Lys Ala Val Thr Leu Val Glu Asn His Asp Thr Gln Pro Gly Gln Ser 
                325                 330                 335     


Leu Glu Ser Thr Val Gln Pro Trp Phe Lys Pro Leu Ala Tyr Ala Phe 
            340                 345                 350         


Ile Leu Thr Arg Ser Gly Gly Tyr Pro Ser Val Phe Tyr Gly Asp Met 
        355                 360                 365             


Tyr Gly Thr Lys Gly Thr Thr Thr Arg Glu Ile Pro Ala Leu Lys Ser 
    370                 375                 380                 


Lys Ile Glu Pro Leu Leu Lys Ala Arg Lys Asp Tyr Ala Tyr Gly Thr 
385                 390                 395                 400 


Gln Arg Asp Tyr Ile Asp Asn Pro Asp Val Ile Gly Trp Thr Arg Glu 
                405                 410                 415     


Gly Asp Ser Thr Lys Ala Lys Ser Gly Leu Ala Thr Val Ile Thr Asp 
            420                 425                 430         


Gly Pro Gly Gly Ser Lys Arg Met Tyr Val Gly Thr Ser Asn Ala Gly 
        435                 440                 445             


Glu Ile Trp Tyr Asp Leu Thr Gly Asn Arg Thr Asp Lys Ile Thr Ile 
    450                 455                 460                 


Gly Ser Asp Gly Tyr Ala Thr Phe Pro Val Asn Gly Gly Ser Val Ser 
465                 470                 475                 480 


Val Trp Val Gln Gln 
                485 


<210>  146
<211>  485
<212>  PRT
<213>  Artifical Sequence

<400>  146

Ala Ala Thr Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr Val Pro 
1               5                   10                  15      


Asn Asp Gly Gln Gln Trp Asn Arg Leu Arg Thr Asp Ala Pro Tyr Leu 
            20                  25                  30          


Ser Ser Val Gly Ile Thr Ala Val Trp Thr Pro Pro Ala Tyr Lys Gly 
        35                  40                  45              


Thr Ser Gln Ala Asp Val Gly Tyr Gly Pro Tyr Asp Leu Tyr Asp Leu 
    50                  55                  60                  


Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly Thr Lys 
65                  70                  75                  80  


Gly Glu Leu Lys Ser Ala Val Asn Thr Leu His Ser Asn Gly Ile Gln 
                85                  90                  95      


Val Tyr Gly Asp Val Val Met Asn His Lys Ala Gly Ala Asp Gly Thr 
            100                 105                 110         


Glu Phe Val Asp Ala Val Glu Val Asn Pro Ser Asn Arg Asn Gln Glu 
        115                 120                 125             


Thr Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp Phe Pro 
    130                 135                 140                 


Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr His Phe 
145                 150                 155                 160 


Asp Gly Thr Asp Trp Asp Glu Ser Arg Lys Leu Asn Arg Val Tyr Lys 
                165                 170                 175     


Phe Arg Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Asp Thr Glu Asn 
            180                 185                 190         


Gly Asn Tyr Asp Tyr Leu Met Phe Ala Asp Leu Asp Tyr Asp His Pro 
        195                 200                 205             


Asp Val Val Asn Glu Met Lys Lys Trp Gly Val Trp Tyr Ala Asn Glu 
    210                 215                 220                 


Val Gly Leu Asp Gly Tyr Arg Leu Asp Ala Val Lys His Ile Lys Phe 
225                 230                 235                 240 


Ser Phe Leu Lys Asp Trp Val Asp Asn Ala Arg Ala Ala Thr Gly Lys 
                245                 250                 255     


Glu Met Phe Thr Val Gly Glu Tyr Trp Gln Asn Asp Leu Gly Ala Leu 
            260                 265                 270         


Asn Asn Tyr Leu Ala Lys Val Asn Tyr Asn Gln Ser Leu Phe Asp Ala 
        275                 280                 285             


Pro Leu His Tyr Asn Phe Tyr Ala Ala Ser Thr Gly Gly Gly Tyr Tyr 
    290                 295                 300                 


Asp Met Arg Asn Ile Leu Asn Asn Thr Leu Val Ala Ser Asn Pro Thr 
305                 310                 315                 320 


Lys Ala Val Thr Leu Val Glu Asn His Asp Thr Gln Pro Gly Gln Ser 
                325                 330                 335     


Leu Glu Ser Thr Val Gln Pro Trp Phe Lys Pro Leu Ala Tyr Ala Phe 
            340                 345                 350         


Ile Leu Thr Arg Ser Gly Gly Tyr Pro Ser Val Phe Tyr Gly Asp Met 
        355                 360                 365             


Tyr Gly Thr Lys Gly Thr Thr Thr Arg Glu Ile Pro Ala Leu Lys Ser 
    370                 375                 380                 


Lys Ile Glu Pro Leu Leu Lys Ala Arg Lys Asp Tyr Ala Tyr Gly Thr 
385                 390                 395                 400 


Gln Arg Asp Tyr Ile Asp Asn Pro Asp Val Ile Gly Trp Thr Arg Glu 
                405                 410                 415     


Gly Asp Ser Thr Lys Ala Lys Ser Gly Leu Ala Thr Val Ile Thr Asp 
            420                 425                 430         


Gly Pro Gly Gly Ser Lys Arg Met Tyr Val Gly Thr Ser Asn Ala Gly 
        435                 440                 445             


Glu Ile Trp Tyr Asp Leu Thr Gly Asn Arg Thr Asp Lys Ile Thr Ile 
    450                 455                 460                 


Gly Ser Asp Gly Tyr Ala Thr Phe Pro Val Asn Gly Gly Ser Val Ser 
465                 470                 475                 480 


Val Trp Val Gln Gln 
                485 


<210>  147
<211>  484
<212>  PRT
<213>  Artifical Sequence

<400>  147

Ala Ala Thr Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr Val Pro 
1               5                   10                  15      


Asn Asp Gly Gln Gln Trp Asn Arg Leu Arg Thr Asp Ala Pro Tyr Leu 
            20                  25                  30          


Ser Ser Val Gly Ile Thr Ala Val Trp Thr Pro Pro Ala Tyr Lys Gly 
        35                  40                  45              


Thr Ser Gln Ala Asp Val Gly Tyr Gly Pro Tyr Asp Leu Tyr Asp Leu 
    50                  55                  60                  


Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly Thr Lys 
65                  70                  75                  80  


Gly Glu Leu Lys Ser Ala Val Asn Thr Leu His Ser Asn Gly Ile Gln 
                85                  90                  95      


Val Tyr Gly Asp Val Val Met Asn His Lys Ala Gly Ala Asp Gly Thr 
            100                 105                 110         


Glu Phe Val Asp Ala Val Glu Val Asp Pro Ser Asn Arg Asn Gln Glu 
        115                 120                 125             


Thr Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp Phe Pro 
    130                 135                 140                 


Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr His Phe 
145                 150                 155                 160 


Asp Gly Thr Asp Trp Asp Glu Ser Arg Lys Leu Asn Arg Ile Tyr Lys 
                165                 170                 175     


Phe Ser Thr Gly Lys Ala Trp Asp Trp Glu Val Asp Thr Glu Asn Gly 
            180                 185                 190         


Asn Tyr Asp Tyr Leu Met Phe Ala Asp Leu Asp Tyr Asp His Pro Asp 
        195                 200                 205             


Val Val Asn Glu Met Lys Lys Trp Gly Val Trp Tyr Ala Asn Glu Val 
    210                 215                 220                 


Gly Leu Asp Gly Tyr Arg Leu Asp Ala Val Lys His Ile Lys Phe Ser 
225                 230                 235                 240 


Phe Leu Lys Asp Trp Val Asp Asn Ala Arg Ala Ala Thr Gly Lys Glu 
                245                 250                 255     


Met Phe Thr Val Gly Glu Tyr Trp Gln Asn Asp Leu Gly Ala Leu Asn 
            260                 265                 270         


Asn Tyr Leu Ala Lys Val Asn Tyr Asn Gln Ser Leu Phe Asp Ala Pro 
        275                 280                 285             


Leu His Tyr Asn Phe Tyr Ala Ala Ser Thr Gly Gly Gly Tyr Tyr Asp 
    290                 295                 300                 


Met Arg Asn Ile Leu Asn Asn Thr Leu Val Ala Ser Asn Pro Thr Lys 
305                 310                 315                 320 


Ala Val Thr Leu Val Glu Asn His Asp Thr Gln Pro Gly Gln Ser Leu 
                325                 330                 335     


Glu Ser Thr Val Gln Pro Trp Phe Lys Pro Leu Ala Tyr Ala Phe Ile 
            340                 345                 350         


Leu Thr Arg Ser Gly Gly Tyr Pro Ser Val Phe Tyr Gly Asp Met Tyr 
        355                 360                 365             


Gly Thr Lys Gly Thr Thr Thr Arg Glu Ile Pro Ala Leu Lys Ser Lys 
    370                 375                 380                 


Ile Glu Pro Leu Leu Lys Ala Arg Lys Asp Tyr Ala Tyr Gly Thr Gln 
385                 390                 395                 400 


Arg Asp Tyr Ile Asp Asn Pro Asp Val Ile Gly Trp Thr Arg Glu Gly 
                405                 410                 415     


Asp Ser Thr Lys Ala Lys Ser Gly Leu Ala Thr Val Ile Thr Asp Gly 
            420                 425                 430         


Pro Gly Gly Ser Lys Arg Met Tyr Val Gly Thr Ser Asn Ala Gly Glu 
        435                 440                 445             


Ile Trp Tyr Asp Leu Thr Gly Asn Arg Thr Asp Lys Ile Thr Ile Gly 
    450                 455                 460                 


Ser Asp Gly Tyr Ala Thr Phe Pro Val Asn Gly Gly Ser Val Ser Val 
465                 470                 475                 480 


Trp Val Gln Gln 
                


<210>  148
<211>  485
<212>  PRT
<213>  Artifical Sequence

<400>  148

Ala Ala Thr Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr Val Pro 
1               5                   10                  15      


Asn Asp Gly Gln Gln Trp Asn Arg Leu Arg Thr Asp Ala Pro Tyr Leu 
            20                  25                  30          


Ser Ser Val Gly Ile Thr Ala Val Trp Thr Pro Pro Ala Tyr Lys Gly 
        35                  40                  45              


Thr Ser Gln Ala Asp Val Gly Tyr Gly Pro Tyr Asp Leu Tyr Asp Leu 
    50                  55                  60                  


Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly Thr Lys 
65                  70                  75                  80  


Gly Glu Leu Lys Ser Ala Val Asn Thr Leu His Ser Asn Gly Ile Gln 
                85                  90                  95      


Val Tyr Gly Asp Val Val Met Asn His Lys Ala Gly Ala Asp Gly Thr 
            100                 105                 110         


Glu Phe Val Asp Ala Val Glu Val Asn Pro Ser Asn Arg Asn Gln Glu 
        115                 120                 125             


Thr Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp Phe Pro 
    130                 135                 140                 


Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr His Phe 
145                 150                 155                 160 


Asp Gly Thr Asp Trp Asp Glu Ser Arg Lys Leu Asn Arg Ile Tyr Lys 
                165                 170                 175     


Phe Arg Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Asp Thr Glu Asn 
            180                 185                 190         


Gly Asn Tyr Asp Tyr Leu Met Phe Ala Asp Leu Asp Tyr Asp His Pro 
        195                 200                 205             


Asp Val Val Asn Glu Met Lys Lys Trp Gly Val Trp Tyr Ala Asn Glu 
    210                 215                 220                 


Val Gly Leu Asp Gly Tyr Arg Leu Asp Ala Val Lys His Ile Lys Phe 
225                 230                 235                 240 


Ser Phe Leu Lys Asp Trp Val Asp Asn Ala Arg Ala Ala Thr Gly Lys 
                245                 250                 255     


Glu Met Phe Thr Val Gly Glu Tyr Trp Gln Asn Asp Leu Gly Ala Leu 
            260                 265                 270         


Asn Asn Tyr Leu Ala Lys Val Asn Tyr Asn Gln Ser Leu Phe Asp Ala 
        275                 280                 285             


Pro Leu His Tyr Asn Phe Tyr Ala Ala Ser Thr Gly Gly Gly Tyr Tyr 
    290                 295                 300                 


Asp Met Arg Asn Ile Leu Asn Asn Thr Leu Val Ala Ser Asn Pro Thr 
305                 310                 315                 320 


Lys Ala Val Thr Leu Val Glu Asn His Asp Thr Gln Pro Gly Gln Ser 
                325                 330                 335     


Leu Glu Ser Thr Val Gln Pro Trp Phe Lys Pro Leu Ala Tyr Ala Phe 
            340                 345                 350         


Ile Leu Thr Arg Ser Gly Gly Tyr Pro Ser Val Phe Tyr Gly Asp Met 
        355                 360                 365             


Tyr Gly Thr Lys Gly Thr Thr Thr Arg Glu Ile Pro Ala Leu Lys Ser 
    370                 375                 380                 


Lys Ile Glu Pro Leu Leu Lys Ala Arg Lys Asp Tyr Ala Tyr Gly Thr 
385                 390                 395                 400 


Gln Arg Asp Tyr Ile Asp Asn Pro Asp Val Ile Gly Trp Thr Arg Glu 
                405                 410                 415     


Gly Asp Ser Thr Lys Ala Lys Ser Gly Leu Ala Thr Val Ile Thr Asp 
            420                 425                 430         


Gly Pro Gly Gly Ser Lys Arg Met Tyr Val Gly Thr Ser Asn Ala Gly 
        435                 440                 445             


Glu Ile Trp Tyr Asp Leu Thr Gly Asn Arg Thr Asp Lys Ile Thr Ile 
    450                 455                 460                 


Gly Ser Asp Gly Tyr Ala Thr Phe Pro Val Asn Gly Gly Ser Val Ser 
465                 470                 475                 480 


Val Trp Val Gln Gln 
                485 


<210>  149
<211>  485
<212>  PRT
<213>  Artifical Sequence

<400>  149

Ala Ala Thr Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr Val Pro 
1               5                   10                  15      


Asn Asp Gly Gln Gln Trp Asn Arg Leu Arg Thr Asp Ala Pro Tyr Leu 
            20                  25                  30          


Ser Ser Val Gly Ile Thr Ala Val Trp Thr Pro Pro Ala Tyr Lys Gly 
        35                  40                  45              


Thr Ser Gln Ala Asp Val Gly Tyr Gly Pro Tyr Asp Leu Tyr Asp Leu 
    50                  55                  60                  


Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly Thr Lys 
65                  70                  75                  80  


Gly Glu Leu Lys Ser Ala Val Asn Thr Leu His Ser Asn Gly Ile Gln 
                85                  90                  95      


Val Tyr Gly Asp Val Val Met Asn His Lys Ala Gly Ala Asp Ala Thr 
            100                 105                 110         


Glu Trp Val Asp Ala Val Glu Val Asn Pro Ser Asn Arg Asn Gln Glu 
        115                 120                 125             


Val Ser Gly Thr Tyr Lys Ile Gln Ala Trp Thr Lys Phe Asp Phe Pro 
    130                 135                 140                 


Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr His Phe 
145                 150                 155                 160 


Asp Gly Thr Asp Trp Asp Gln Ser Arg Gln Leu Asn Arg Ile Tyr Lys 
                165                 170                 175     


Phe Arg Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Asp Thr Glu Asn 
            180                 185                 190         


Gly Asn Tyr Asp Tyr Leu Met Phe Ala Asp Leu Asp Tyr Asp His Pro 
        195                 200                 205             


Asp Val Val Asn Glu Met Lys Lys Trp Gly Val Trp Tyr Ala Asn Glu 
    210                 215                 220                 


Val Gly Leu Asp Gly Tyr Arg Leu Asp Ala Val Lys His Ile Lys Phe 
225                 230                 235                 240 


Ser Phe Leu Lys Asp Trp Val Asp Asn Ala Arg Ala Ala Thr Gly Lys 
                245                 250                 255     


Glu Met Phe Thr Val Gly Glu Tyr Trp Gln Asn Asp Leu Gly Ala Leu 
            260                 265                 270         


Asn Asn Tyr Leu Ala Lys Val Asn Tyr Asn Gln Ser Leu Phe Asp Ala 
        275                 280                 285             


Pro Leu His Tyr Asn Phe Tyr Ala Ala Ser Thr Gly Gly Gly Tyr Tyr 
    290                 295                 300                 


Asp Met Arg Asn Ile Leu Asn Asn Thr Leu Val Ala Ser Asn Pro Thr 
305                 310                 315                 320 


Lys Ala Val Thr Leu Val Glu Asn His Asp Thr Gln Pro Gly Gln Ser 
                325                 330                 335     


Leu Glu Ser Thr Val Gln Pro Trp Phe Lys Pro Leu Ala Tyr Ala Phe 
            340                 345                 350         


Ile Leu Thr Arg Ser Gly Gly Tyr Pro Ser Val Phe Tyr Gly Asp Met 
        355                 360                 365             


Tyr Gly Thr Lys Gly Thr Thr Thr Arg Glu Ile Pro Ala Leu Lys Ser 
    370                 375                 380                 


Lys Ile Glu Pro Leu Leu Lys Ala Arg Lys Asp Tyr Ala Tyr Gly Thr 
385                 390                 395                 400 


Gln Arg Asp Tyr Ile Asp Asn Pro Asp Val Ile Gly Trp Thr Arg Glu 
                405                 410                 415     


Gly Asp Ser Thr Lys Ala Lys Ser Gly Leu Ala Thr Val Ile Thr Asp 
            420                 425                 430         


Gly Pro Gly Gly Ser Lys Arg Met Tyr Val Gly Thr Ser Asn Ala Gly 
        435                 440                 445             


Glu Ile Trp Tyr Asp Leu Thr Gly Asn Arg Thr Asp Lys Ile Thr Ile 
    450                 455                 460                 


Gly Ser Asp Gly Tyr Ala Thr Phe Pro Val Asn Gly Gly Ser Val Ser 
465                 470                 475                 480 


Val Trp Val Gln Gln 
                485 


<210>  150
<211>  485
<212>  PRT
<213>  Artifiical Sequence

<400>  150

Ala Ala Thr Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr Val Pro 
1               5                   10                  15      


Asn Asp Gly Gln Gln Trp Asn Arg Leu Arg Thr Asp Ala Pro Tyr Leu 
            20                  25                  30          


Ser Ser Val Gly Ile Thr Ala Val Trp Thr Pro Pro Ala Tyr Lys Gly 
        35                  40                  45              


Thr Ser Gln Ala Asp Val Gly Tyr Gly Pro Tyr Asp Leu Tyr Asp Leu 
    50                  55                  60                  


Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly Thr Lys 
65                  70                  75                  80  


Gly Glu Leu Lys Ser Ala Val Asn Thr Leu His Ser Asn Gly Ile Gln 
                85                  90                  95      


Val Tyr Gly Asp Val Val Met Asn His Lys Ala Gly Ala Asp Ser Thr 
            100                 105                 110         


Glu Trp Val Asp Ala Val Glu Val Asn Pro Ser Asn Arg Asn Gln Glu 
        115                 120                 125             


Thr Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp Phe Pro 
    130                 135                 140                 


Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr His Phe 
145                 150                 155                 160 


Asp Gly Thr Asp Trp Asp Glu Ser Arg Lys Leu Asn Arg Ile Tyr Lys 
                165                 170                 175     


Phe Arg Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Asp Thr Glu Asn 
            180                 185                 190         


Gly Asn Tyr Asp Tyr Leu Met Phe Ala Asp Leu Asp Tyr Asp His Pro 
        195                 200                 205             


Asp Val Val Asn Glu Met Lys Lys Trp Gly Val Trp Tyr Ala Asn Glu 
    210                 215                 220                 


Val Gly Leu Asp Gly Tyr Arg Leu Asp Ala Val Lys His Ile Lys Phe 
225                 230                 235                 240 


Ser Phe Leu Lys Asp Trp Val Asp Asn Ala Arg Ala Ala Thr Gly Lys 
                245                 250                 255     


Glu Met Phe Thr Val Gly Glu Tyr Trp Gln Asn Asp Leu Gly Ala Leu 
            260                 265                 270         


Asn Asn Tyr Leu Ala Lys Val Asn Tyr Asn Gln Ser Leu Phe Asp Ala 
        275                 280                 285             


Pro Leu His Tyr Asn Phe Tyr Ala Ala Ser Thr Gly Gly Gly Tyr Tyr 
    290                 295                 300                 


Asp Met Arg Asn Ile Leu Asn Asn Thr Leu Val Ala Ser Asn Pro Thr 
305                 310                 315                 320 


Lys Ala Val Thr Leu Val Glu Asn His Asp Thr Gln Pro Gly Gln Ser 
                325                 330                 335     


Leu Glu Ser Thr Val Gln Pro Trp Phe Lys Pro Leu Ala Tyr Ala Phe 
            340                 345                 350         


Ile Leu Thr Arg Ser Gly Gly Tyr Pro Ser Val Phe Tyr Gly Asp Met 
        355                 360                 365             


Tyr Gly Thr Lys Gly Thr Thr Thr Arg Glu Ile Pro Ala Leu Lys Ser 
    370                 375                 380                 


Lys Ile Glu Pro Leu Leu Lys Ala Arg Lys Asp Tyr Ala Tyr Gly Thr 
385                 390                 395                 400 


Gln Arg Asp Tyr Ile Asp Asn Pro Asp Val Ile Gly Trp Thr Arg Glu 
                405                 410                 415     


Gly Asp Ser Thr Lys Ala Lys Ser Gly Leu Ala Thr Val Ile Thr Asp 
            420                 425                 430         


Gly Pro Gly Gly Ser Lys Arg Met Tyr Val Gly Thr Ser Asn Ala Gly 
        435                 440                 445             


Glu Ile Trp Tyr Asp Leu Thr Gly Asn Arg Thr Asp Lys Ile Thr Ile 
    450                 455                 460                 


Gly Ser Asp Gly Tyr Ala Thr Phe Pro Val Asn Gly Gly Ser Val Ser 
465                 470                 475                 480 


Val Trp Val Gln Gln 
                485 


<210>  151
<211>  486
<212>  PRT
<213>  Artifical Sequence

<400>  151

Ala Ala Thr Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr Val Pro 
1               5                   10                  15      


Asn Asp Gly Gln Gln Trp Asn Arg Leu Arg Thr Asp Ala Pro Tyr Leu 
            20                  25                  30          


Ser Ser Val Gly Ile Thr Ala Val Trp Thr Pro Pro Ala Tyr Lys Gly 
        35                  40                  45              


Thr Ser Gln Ala Asp Val Gly Tyr Gly Pro Tyr Asp Leu Tyr Asp Leu 
    50                  55                  60                  


Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly Thr Lys 
65                  70                  75                  80  


Gly Glu Leu Lys Ser Ala Val Asn Thr Leu His Ser Asn Gly Ile Gln 
                85                  90                  95      


Val Tyr Gly Asp Val Val Met Asn His Lys Gly Gly Ala Asp Phe Thr 
            100                 105                 110         


Glu Arg Val Gln Ala Val Glu Val Asn Pro Gln Asn Arg Asn Gln Glu 
        115                 120                 125             


Val Ser Gly Thr Tyr Gln Ile Glu Ala Trp Thr Gly Phe Asn Phe Pro 
    130                 135                 140                 


Gly Arg Gly Asn Gln His Ser Ser Phe Lys Trp Arg Trp Tyr His Phe 
145                 150                 155                 160 


Asp Gly Thr Asp Trp Asp Gln Ser Arg Gln Leu Ala Asn Arg Ile Tyr 
                165                 170                 175     


Lys Phe Arg Gly Asp Gly Lys Ala Trp Asp Trp Glu Val Asp Thr Glu 
            180                 185                 190         


Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Val Asp Tyr Asp His 
        195                 200                 205             


Pro Asp Val Val Asn Glu Met Lys Lys Trp Gly Val Trp Tyr Ala Asn 
    210                 215                 220                 


Glu Val Gly Leu Asp Gly Tyr Arg Leu Asp Ala Val Lys His Ile Lys 
225                 230                 235                 240 


Phe Ser Phe Leu Lys Asp Trp Val Asp Asn Ala Arg Ala Ala Thr Gly 
                245                 250                 255     


Lys Glu Met Phe Thr Val Gly Glu Tyr Trp Gln Asn Asp Leu Gly Ala 
            260                 265                 270         


Leu Asn Asn Tyr Leu Ala Lys Val Asn Tyr Asn Gln Ser Leu Phe Asp 
        275                 280                 285             


Ala Pro Leu His Tyr Asn Phe Tyr Ala Ala Ser Thr Gly Gly Gly Tyr 
    290                 295                 300                 


Tyr Asp Met Arg Asn Ile Leu Asn Asn Thr Leu Val Ala Ser Asn Pro 
305                 310                 315                 320 


Thr Lys Ala Val Thr Leu Val Glu Asn His Asp Thr Gln Pro Gly Gln 
                325                 330                 335     


Ser Leu Glu Ser Thr Val Gln Pro Trp Phe Lys Pro Leu Ala Tyr Ala 
            340                 345                 350         


Phe Ile Leu Thr Arg Ser Gly Gly Tyr Pro Ser Val Phe Tyr Gly Asp 
        355                 360                 365             


Met Tyr Gly Thr Lys Gly Thr Thr Thr Arg Glu Ile Pro Ala Leu Lys 
    370                 375                 380                 


Ser Lys Ile Glu Pro Leu Leu Lys Ala Arg Lys Asp Tyr Ala Tyr Gly 
385                 390                 395                 400 


Thr Gln Arg Asp Tyr Ile Asp Asn Pro Asp Val Ile Gly Trp Thr Arg 
                405                 410                 415     


Glu Gly Asp Ser Thr Lys Ala Lys Ser Gly Leu Ala Thr Val Ile Thr 
            420                 425                 430         


Asp Gly Pro Gly Gly Ser Lys Arg Met Tyr Val Gly Thr Ser Asn Ala 
        435                 440                 445             


Gly Glu Ile Trp Tyr Asp Leu Thr Gly Asn Arg Thr Asp Lys Ile Thr 
    450                 455                 460                 


Ile Gly Ser Asp Gly Tyr Ala Thr Phe Pro Val Asn Gly Gly Ser Val 
465                 470                 475                 480 


Ser Val Trp Val Gln Gln 
                485     


<210>  152
<211>  486
<212>  PRT
<213>  Artfical Sequence

<400>  152

Ala Ala Thr Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr Val Pro 
1               5                   10                  15      


Asn Asp Gly Gln Gln Trp Asn Arg Leu Arg Thr Asp Ala Pro Tyr Leu 
            20                  25                  30          


Ser Ser Val Gly Ile Thr Ala Val Trp Thr Pro Pro Ala Tyr Lys Gly 
        35                  40                  45              


Thr Ser Gln Ala Asp Val Gly Tyr Gly Pro Tyr Asp Leu Tyr Asp Leu 
    50                  55                  60                  


Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly Thr Lys 
65                  70                  75                  80  


Gly Glu Leu Lys Ser Ala Val Asn Thr Leu His Ser Asn Gly Ile Gln 
                85                  90                  95      


Val Tyr Gly Asp Val Val Met Asn His Lys Gly Gly Ala Asp Ala Thr 
            100                 105                 110         


Glu Asn Val Leu Ala Val Glu Val Asn Pro Asn Asn Arg Asn Gln Glu 
        115                 120                 125             


Ile Ser Gly Asp Tyr Thr Ile Glu Ala Trp Thr Lys Phe Asp Phe Pro 
    130                 135                 140                 


Gly Arg Gly Asn Thr Tyr Ser Asp Phe Lys Trp Arg Trp Tyr His Phe 
145                 150                 155                 160 


Asp Gly Val Asp Trp Asp Gln Ser Arg Gln Phe Gln Asn Arg Ile Tyr 
                165                 170                 175     


Lys Phe Arg Gly Asp Gly Lys Ala Trp Asp Trp Glu Val Asp Ser Glu 
            180                 185                 190         


Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Val Asp Tyr Asp His 
        195                 200                 205             


Pro Asp Val Val Asn Glu Met Lys Lys Trp Gly Val Trp Tyr Ala Asn 
    210                 215                 220                 


Glu Val Gly Leu Asp Gly Tyr Arg Leu Asp Ala Val Lys His Ile Lys 
225                 230                 235                 240 


Phe Ser Phe Leu Lys Asp Trp Val Asp Asn Ala Arg Ala Ala Thr Gly 
                245                 250                 255     


Lys Glu Met Phe Thr Val Gly Glu Tyr Trp Gln Asn Asp Leu Gly Ala 
            260                 265                 270         


Leu Asn Asn Tyr Leu Ala Lys Val Asn Tyr Asn Gln Ser Leu Phe Asp 
        275                 280                 285             


Ala Pro Leu His Tyr Asn Phe Tyr Ala Ala Ser Thr Gly Gly Gly Tyr 
    290                 295                 300                 


Tyr Asp Met Arg Asn Ile Leu Asn Asn Thr Leu Val Ala Ser Asn Pro 
305                 310                 315                 320 


Thr Lys Ala Val Thr Leu Val Glu Asn His Asp Thr Gln Pro Gly Gln 
                325                 330                 335     


Ser Leu Glu Ser Thr Val Gln Pro Trp Phe Lys Pro Leu Ala Tyr Ala 
            340                 345                 350         


Phe Ile Leu Thr Arg Ser Gly Gly Tyr Pro Ser Val Phe Tyr Gly Asp 
        355                 360                 365             


Met Tyr Gly Thr Lys Gly Thr Thr Thr Arg Glu Ile Pro Ala Leu Lys 
    370                 375                 380                 


Ser Lys Ile Glu Pro Leu Leu Lys Ala Arg Lys Asp Tyr Ala Tyr Gly 
385                 390                 395                 400 


Thr Gln Arg Asp Tyr Ile Asp Asn Pro Asp Val Ile Gly Trp Thr Arg 
                405                 410                 415     


Glu Gly Asp Ser Thr Lys Ala Lys Ser Gly Leu Ala Thr Val Ile Thr 
            420                 425                 430         


Asp Gly Pro Gly Gly Ser Lys Arg Met Tyr Val Gly Thr Ser Asn Ala 
        435                 440                 445             


Gly Glu Ile Trp Tyr Asp Leu Thr Gly Asn Arg Thr Asp Lys Ile Thr 
    450                 455                 460                 


Ile Gly Ser Asp Gly Tyr Ala Thr Phe Pro Val Asn Gly Gly Ser Val 
465                 470                 475                 480 


Ser Val Trp Val Gln Gln 
                485     


<210>  153
<211>  486
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  153

Ala Ala Thr Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr Val Pro 
1               5                   10                  15      


Asn Asp Gly Gln Gln Trp Asn Arg Leu Arg Thr Asp Ala Pro Tyr Leu 
            20                  25                  30          


Ser Ser Val Gly Ile Thr Ala Val Trp Thr Pro Pro Ala Tyr Lys Gly 
        35                  40                  45              


Thr Ser Gln Ala Asp Val Gly Tyr Gly Pro Tyr Asp Leu Tyr Asp Leu 
    50                  55                  60                  


Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly Thr Lys 
65                  70                  75                  80  


Gly Glu Leu Lys Ser Ala Val Asn Thr Leu His Ser Asn Gly Ile Gln 
                85                  90                  95      


Val Tyr Gly Asp Val Val Met Asn His Lys Gly Gly Ala Asp Ala Thr 
            100                 105                 110         


Glu Met Val Arg Ala Val Glu Val Asn Pro Asn Asn Arg Asn Gln Glu 
        115                 120                 125             


Val Ser Gly Glu Tyr Thr Ile Glu Ala Trp Thr Lys Phe Asp Phe Pro 
    130                 135                 140                 


Gly Arg Gly Asn Thr His Ser Asn Phe Lys Trp Arg Trp Tyr His Phe 
145                 150                 155                 160 


Asp Gly Val Asp Trp Asp Gln Ser Arg Lys Leu Asn Asn Arg Ile Tyr 
                165                 170                 175     


Lys Phe Arg Gly Asp Gly Lys Gly Trp Asp Trp Glu Val Asp Thr Glu 
            180                 185                 190         


Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Ile Asp Tyr Asp His 
        195                 200                 205             


Pro Asp Val Val Asn Glu Met Lys Lys Trp Gly Val Trp Tyr Ala Asn 
    210                 215                 220                 


Glu Val Gly Leu Asp Gly Tyr Arg Leu Asp Ala Val Lys His Ile Lys 
225                 230                 235                 240 


Phe Ser Phe Leu Lys Asp Trp Val Asp Asn Ala Arg Ala Ala Thr Gly 
                245                 250                 255     


Lys Glu Met Phe Thr Val Gly Glu Tyr Trp Gln Asn Asp Leu Gly Ala 
            260                 265                 270         


Leu Asn Asn Tyr Leu Ala Lys Val Asn Tyr Asn Gln Ser Leu Phe Asp 
        275                 280                 285             


Ala Pro Leu His Tyr Asn Phe Tyr Ala Ala Ser Thr Gly Gly Gly Tyr 
    290                 295                 300                 


Tyr Asp Met Arg Asn Ile Leu Asn Asn Thr Leu Val Ala Ser Asn Pro 
305                 310                 315                 320 


Thr Lys Ala Val Thr Leu Val Glu Asn His Asp Thr Gln Pro Gly Gln 
                325                 330                 335     


Ser Leu Glu Ser Thr Val Gln Pro Trp Phe Lys Pro Leu Ala Tyr Ala 
            340                 345                 350         


Phe Ile Leu Thr Arg Ser Gly Gly Tyr Pro Ser Val Phe Tyr Gly Asp 
        355                 360                 365             


Met Tyr Gly Thr Lys Gly Thr Thr Thr Arg Glu Ile Pro Ala Leu Lys 
    370                 375                 380                 


Ser Lys Ile Glu Pro Leu Leu Lys Ala Arg Lys Asp Tyr Ala Tyr Gly 
385                 390                 395                 400 


Thr Gln Arg Asp Tyr Ile Asp Asn Pro Asp Val Ile Gly Trp Thr Arg 
                405                 410                 415     


Glu Gly Asp Ser Thr Lys Ala Lys Ser Gly Leu Ala Thr Val Ile Thr 
            420                 425                 430         


Asp Gly Pro Gly Gly Ser Lys Arg Met Tyr Val Gly Thr Ser Asn Ala 
        435                 440                 445             


Gly Glu Ile Trp Tyr Asp Leu Thr Gly Asn Arg Thr Asp Lys Ile Thr 
    450                 455                 460                 


Ile Gly Ser Asp Gly Tyr Ala Thr Phe Pro Val Asn Gly Gly Ser Val 
465                 470                 475                 480 


Ser Val Trp Val Gln Gln 
                485     


<210>  154
<211>  486
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  154

Ala Ala Thr Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr Val Pro 
1               5                   10                  15      


Asn Asp Gly Gln Gln Trp Asn Arg Leu Arg Thr Asp Ala Pro Tyr Leu 
            20                  25                  30          


Ser Ser Val Gly Ile Thr Ala Val Trp Thr Pro Pro Ala Tyr Lys Gly 
        35                  40                  45              


Thr Ser Gln Ala Asp Val Gly Tyr Gly Pro Tyr Asp Leu Tyr Asp Leu 
    50                  55                  60                  


Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly Thr Lys 
65                  70                  75                  80  


Gly Glu Leu Lys Ser Ala Val Asn Thr Leu His Ser Asn Gly Ile Gln 
                85                  90                  95      


Val Tyr Gly Asp Val Val Met Asn His Lys Gly Gly Ala Asp Ala Thr 
            100                 105                 110         


Glu Met Val Arg Ala Val Glu Val Asn Pro Asn Asn Arg Asn Gln Glu 
        115                 120                 125             


Val Thr Gly Glu Tyr Thr Ile Glu Ala Trp Thr Arg Phe Asp Phe Pro 
    130                 135                 140                 


Gly Arg Gly Asn Thr His Ser Ser Phe Lys Trp Arg Trp Tyr His Phe 
145                 150                 155                 160 


Asp Gly Val Asp Trp Asp Gln Ser Arg Arg Leu Asn Asn Arg Ile Tyr 
                165                 170                 175     


Lys Phe Arg Gly His Gly Lys Ala Trp Asp Trp Glu Val Asp Thr Glu 
            180                 185                 190         


Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Ile Asp Tyr Asp His 
        195                 200                 205             


Pro Asp Val Val Asn Glu Met Lys Lys Trp Gly Val Trp Tyr Ala Asn 
    210                 215                 220                 


Glu Val Gly Leu Asp Gly Tyr Arg Leu Asp Ala Val Lys His Ile Lys 
225                 230                 235                 240 


Phe Ser Phe Leu Lys Asp Trp Val Asp Asn Ala Arg Ala Ala Thr Gly 
                245                 250                 255     


Lys Glu Met Phe Thr Val Gly Glu Tyr Trp Gln Asn Asp Leu Gly Ala 
            260                 265                 270         


Leu Asn Asn Tyr Leu Ala Lys Val Asn Tyr Asn Gln Ser Leu Phe Asp 
        275                 280                 285             


Ala Pro Leu His Tyr Asn Phe Tyr Ala Ala Ser Thr Gly Gly Gly Tyr 
    290                 295                 300                 


Tyr Asp Met Arg Asn Ile Leu Asn Asn Thr Leu Val Ala Ser Asn Pro 
305                 310                 315                 320 


Thr Lys Ala Val Thr Leu Val Glu Asn His Asp Thr Gln Pro Gly Gln 
                325                 330                 335     


Ser Leu Glu Ser Thr Val Gln Pro Trp Phe Lys Pro Leu Ala Tyr Ala 
            340                 345                 350         


Phe Ile Leu Thr Arg Ser Gly Gly Tyr Pro Ser Val Phe Tyr Gly Asp 
        355                 360                 365             


Met Tyr Gly Thr Lys Gly Thr Thr Thr Arg Glu Ile Pro Ala Leu Lys 
    370                 375                 380                 


Ser Lys Ile Glu Pro Leu Leu Lys Ala Arg Lys Asp Tyr Ala Tyr Gly 
385                 390                 395                 400 


Thr Gln Arg Asp Tyr Ile Asp Asn Pro Asp Val Ile Gly Trp Thr Arg 
                405                 410                 415     


Glu Gly Asp Ser Thr Lys Ala Lys Ser Gly Leu Ala Thr Val Ile Thr 
            420                 425                 430         


Asp Gly Pro Gly Gly Ser Lys Arg Met Tyr Val Gly Thr Ser Asn Ala 
        435                 440                 445             


Gly Glu Ile Trp Tyr Asp Leu Thr Gly Asn Arg Thr Asp Lys Ile Thr 
    450                 455                 460                 


Ile Gly Ser Asp Gly Tyr Ala Thr Phe Pro Val Asn Gly Gly Ser Val 
465                 470                 475                 480 


Ser Val Trp Val Gln Gln 
                485     


<210>  155
<211>  485
<212>  PRT
<213>  Artifiical Sequence

<400>  155

His His Asp Gly Thr Asn Gly Thr Ile Met Gln Tyr Phe Glu Trp Asn 
1               5                   10                  15      


Val Pro Asn Asp Gly Gln His Trp Asn Arg Leu His Asn Asn Ala Gln 
            20                  25                  30          


Asn Leu Lys Asn Ala Gly Ile Thr Ala Ile Trp Ile Pro Pro Ala Trp 
        35                  40                  45              


Lys Gly Thr Ser Gln Asn Asp Val Gly Tyr Gly Ala Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Ala Glu Leu Glu Arg Ala Ile Arg Ser Leu Lys Ala Asn Gly 
                85                  90                  95      


Ile Gln Val Tyr Gly Asp Val Val Met Asn His Arg Met Gly Ala Asp 
            100                 105                 110         


Ala Thr Glu Thr Ile Ser Ala Val Glu Val Asn Pro Ser Asn Arg Asn 
        115                 120                 125             


Gln Val Thr Ser Gly Ala Tyr Asn Ile Ser Ala Trp Thr Asp Phe Glu 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp His Ser Tyr 
145                 150                 155                 160 


Tyr Phe Asp Gly Val Asp Trp Asp Gln Ser Arg Gln Leu Ser Gly Lys 
                165                 170                 175     


Ile Tyr Gln Ile Gln Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Asp 
            180                 185                 190         


Ser Glu Asn Gly Asn Tyr Asp Tyr Leu Met Gly Ala Asp Ile Asp Met 
        195                 200                 205             


Asp His Pro Glu Val Ile Asn Glu Leu Asn Arg Trp Gly Val Trp Tyr 
    210                 215                 220                 


Ala Asn Thr Leu Asn Leu Asp Gly Phe Arg Leu Asp Ala Val Lys His 
225                 230                 235                 240 


Ile Lys Phe Ser Phe Met Arg Asp Trp Leu Gly His Val Arg Gly Gln 
                245                 250                 255     


Thr Gly Lys Asn Leu Phe Ala Val Ala Glu Tyr Trp Lys Asn Asp Leu 
            260                 265                 270         


Gly Ala Leu Glu Asn Tyr Leu Ser Lys Thr Asn Trp Thr Met Ser Ala 
        275                 280                 285             


Phe Asp Val Pro Leu His Tyr Asn Leu Tyr Gln Ala Ser Asn Ser Ser 
    290                 295                 300                 


Gly Asn Tyr Asp Met Arg Asn Leu Leu Asn Gly Thr Leu Val Gln Arg 
305                 310                 315                 320 


His Pro Ser His Ala Val Thr Phe Val Asp Asn His Asp Thr Gln Pro 
                325                 330                 335     


Gly Glu Ala Leu Glu Ser Phe Val Gln Gly Trp Phe Lys Pro Leu Ala 
            340                 345                 350         


Tyr Ala Thr Ile Leu Thr Arg Glu Gln Gly Tyr Pro Gln Val Phe Tyr 
        355                 360                 365             


Gly Asp Tyr Tyr Gly Ile Pro Ser Asp Gly Val Pro Ser Tyr Arg Gln 
    370                 375                 380                 


Gln Ile Asp Pro Leu Leu Lys Ala Arg Gln Gln Tyr Ala Tyr Gly Arg 
385                 390                 395                 400 


Gln His Asp Tyr Phe Asp His Trp Asp Val Ile Gly Trp Thr Arg Glu 
                405                 410                 415     


Gly Asn Ala Ser His Pro Asn Ser Gly Leu Ala Thr Ile Met Ser Asp 
            420                 425                 430         


Gly Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Arg Gln Lys Ala Gly 
        435                 440                 445             


Glu Val Trp His Asp Met Thr Gly Asn Arg Ser Gly Thr Val Thr Ile 
    450                 455                 460                 


Asn Gln Asp Gly Trp Gly His Phe Phe Val Asn Gly Gly Ser Val Ser 
465                 470                 475                 480 


Val Trp Val Lys Arg 
                485 


<210>  156
<211>  484
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  156

His His Asp Gly Thr Asn Gly Thr Ile Met Gln Tyr Phe Glu Trp Asn 
1               5                   10                  15      


Val Pro Asn Asp Gly Gln His Trp Asn Arg Leu His Asn Asn Ala Gln 
            20                  25                  30          


Asn Leu Lys Asn Ala Gly Ile Thr Ala Ile Trp Ile Pro Pro Ala Trp 
        35                  40                  45              


Lys Gly Thr Ser Gln Asn Asp Val Gly Tyr Gly Ala Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Ala Glu Leu Glu Arg Ala Ile Arg Ser Leu Lys Ala Asn Gly 
                85                  90                  95      


Ile Gln Val Tyr Gly Asp Val Val Met Asn His Lys Ala Gly Ala Asp 
            100                 105                 110         


Ala Thr Glu Asp Val Thr Ala Val Glu Val Asn Pro Ala Asn Arg Asn 
        115                 120                 125             


Gln Glu Thr Ser Glu Glu Tyr Gln Ile Lys Ala Trp Thr Asp Phe Arg 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Asp Phe Lys Trp His Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Ala Asp Trp Asp Glu Ser Arg Lys Ile Ser Arg Ile 
                165                 170                 175     


Phe Lys Phe Arg Gly Glu Gly Lys Ala Trp Asp Trp Glu Val Ser Ser 
            180                 185                 190         


Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Val Asp Met Asp 
        195                 200                 205             


His Pro Glu Val Ile Asn Glu Leu Asn Arg Trp Gly Val Trp Tyr Ala 
    210                 215                 220                 


Asn Thr Leu Asn Leu Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile 
225                 230                 235                 240 


Lys Phe Ser Phe Met Arg Asp Trp Leu Gly His Val Arg Gly Gln Thr 
                245                 250                 255     


Gly Lys Asn Leu Phe Ala Val Ala Glu Tyr Trp Lys Asn Asp Leu Gly 
            260                 265                 270         


Ala Leu Glu Asn Tyr Leu Ser Lys Thr Asn Trp Thr Met Ser Ala Phe 
        275                 280                 285             


Asp Val Pro Leu His Tyr Asn Leu Tyr Gln Ala Ser Asn Ser Ser Gly 
    290                 295                 300                 


Asn Tyr Asp Met Arg Asn Leu Leu Asn Gly Thr Leu Val Gln Arg His 
305                 310                 315                 320 


Pro Ser His Ala Val Thr Phe Val Asp Asn His Asp Thr Gln Pro Gly 
                325                 330                 335     


Glu Ala Leu Glu Ser Phe Val Gln Gly Trp Phe Lys Pro Leu Ala Tyr 
            340                 345                 350         


Ala Thr Ile Leu Thr Arg Glu Gln Gly Tyr Pro Gln Val Phe Tyr Gly 
        355                 360                 365             


Asp Tyr Tyr Gly Ile Pro Ser Asp Gly Val Pro Ser Tyr Arg Gln Gln 
    370                 375                 380                 


Ile Asp Pro Leu Leu Lys Ala Arg Gln Gln Tyr Ala Tyr Gly Arg Gln 
385                 390                 395                 400 


His Asp Tyr Phe Asp His Trp Asp Val Ile Gly Trp Thr Arg Glu Gly 
                405                 410                 415     


Asn Ala Ser His Pro Asn Ser Gly Leu Ala Thr Ile Met Ser Asp Gly 
            420                 425                 430         


Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Arg Gln Lys Ala Gly Glu 
        435                 440                 445             


Val Trp His Asp Met Thr Gly Asn Arg Ser Gly Thr Val Thr Ile Asn 
    450                 455                 460                 


Gln Asp Gly Trp Gly His Phe Phe Val Asn Gly Gly Ser Val Ser Val 
465                 470                 475                 480 


Trp Val Lys Arg 
                


<210>  157
<211>  482
<212>  PRT
<213>  Artifical Sequence

<400>  157

His His Asp Gly Thr Asn Gly Thr Ile Met Gln Tyr Phe Glu Trp Asn 
1               5                   10                  15      


Val Pro Asn Asp Gly Gln His Trp Asn Arg Leu His Asn Asn Ala Gln 
            20                  25                  30          


Asn Leu Lys Asn Ala Gly Ile Thr Ala Ile Trp Ile Pro Pro Ala Trp 
        35                  40                  45              


Lys Gly Thr Ser Gln Asn Asp Val Gly Tyr Gly Ala Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Ala Glu Leu Glu Arg Ala Ile Arg Ser Leu Lys Ala Asn Gly 
                85                  90                  95      


Ile Gln Val Tyr Gly Asp Val Val Met Asn His Lys Gly Gly Ala Asp 
            100                 105                 110         


Ala Thr Glu Asp Val Thr Ala Val Glu Val Asp Pro Ala Asp Arg Asn 
        115                 120                 125             


Arg Val Ile Ser Gly Glu His Leu Ile Lys Ala Trp Thr His Phe His 
    130                 135                 140                 


Phe Pro Gly Arg Gly Ser Thr Tyr Ser Asp Phe Lys Trp His Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Glu Ser Arg Lys Leu Asn Arg Ile 
                165                 170                 175     


Tyr Lys Phe Gln Gly Lys Ala Trp Asp Trp Glu Val Ser Asn Glu Phe 
            180                 185                 190         


Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Ile Asp Met Asp His Pro 
        195                 200                 205             


Glu Val Ile Asn Glu Leu Asn Arg Trp Gly Val Trp Tyr Ala Asn Thr 
    210                 215                 220                 


Leu Asn Leu Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile Lys Phe 
225                 230                 235                 240 


Ser Phe Met Arg Asp Trp Leu Gly His Val Arg Gly Gln Thr Gly Lys 
                245                 250                 255     


Asn Leu Phe Ala Val Ala Glu Tyr Trp Lys Asn Asp Leu Gly Ala Leu 
            260                 265                 270         


Glu Asn Tyr Leu Ser Lys Thr Asn Trp Thr Met Ser Ala Phe Asp Val 
        275                 280                 285             


Pro Leu His Tyr Asn Leu Tyr Gln Ala Ser Asn Ser Ser Gly Asn Tyr 
    290                 295                 300                 


Asp Met Arg Asn Leu Leu Asn Gly Thr Leu Val Gln Arg His Pro Ser 
305                 310                 315                 320 


His Ala Val Thr Phe Val Asp Asn His Asp Thr Gln Pro Gly Glu Ala 
                325                 330                 335     


Leu Glu Ser Phe Val Gln Gly Trp Phe Lys Pro Leu Ala Tyr Ala Thr 
            340                 345                 350         


Ile Leu Thr Arg Glu Gln Gly Tyr Pro Gln Val Phe Tyr Gly Asp Tyr 
        355                 360                 365             


Tyr Gly Ile Pro Ser Asp Gly Val Pro Ser Tyr Arg Gln Gln Ile Asp 
    370                 375                 380                 


Pro Leu Leu Lys Ala Arg Gln Gln Tyr Ala Tyr Gly Arg Gln His Asp 
385                 390                 395                 400 


Tyr Phe Asp His Trp Asp Val Ile Gly Trp Thr Arg Glu Gly Asn Ala 
                405                 410                 415     


Ser His Pro Asn Ser Gly Leu Ala Thr Ile Met Ser Asp Gly Pro Gly 
            420                 425                 430         


Gly Ser Lys Trp Met Tyr Val Gly Arg Gln Lys Ala Gly Glu Val Trp 
        435                 440                 445             


His Asp Met Thr Gly Asn Arg Ser Gly Thr Val Thr Ile Asn Gln Asp 
    450                 455                 460                 


Gly Trp Gly His Phe Phe Val Asn Gly Gly Ser Val Ser Val Trp Val 
465                 470                 475                 480 


Lys Arg 
        


<210>  158
<211>  484
<212>  PRT
<213>  Artifical Sequence

<400>  158

His His Asp Gly Thr Asn Gly Thr Ile Met Gln Tyr Phe Glu Trp Asn 
1               5                   10                  15      


Val Pro Asn Asp Gly Gln His Trp Asn Arg Leu His Asn Asn Ala Gln 
            20                  25                  30          


Asn Leu Lys Asn Ala Gly Ile Thr Ala Ile Trp Ile Pro Pro Ala Trp 
        35                  40                  45              


Lys Gly Thr Ser Gln Asn Asp Val Gly Tyr Gly Ala Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Ala Glu Leu Glu Arg Ala Ile Arg Ser Leu Lys Ala Asn Gly 
                85                  90                  95      


Ile Gln Val Tyr Gly Asp Val Val Met Asn His Lys Ala Gly Ala Asp 
            100                 105                 110         


Tyr Thr Glu Asn Val Thr Ala Val Glu Val Asn Pro Ser Asn Arg Asn 
        115                 120                 125             


Gln Glu Thr Ser Gly Glu Tyr Asn Ile Gln Ala Trp Thr Gly Phe Asn 
    130                 135                 140                 


Phe Pro Gly Arg Gly Thr Thr Tyr Ser Asn Phe Lys Trp Gln Trp Phe 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Gln Ser Arg Ser Leu Ser Arg Ile 
                165                 170                 175     


Phe Lys Phe Arg Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Ser Ser 
            180                 185                 190         


Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Ile Asp Met Asp 
        195                 200                 205             


His Pro Glu Val Ile Asn Glu Leu Asn Arg Trp Gly Val Trp Tyr Ala 
    210                 215                 220                 


Asn Thr Leu Asn Leu Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile 
225                 230                 235                 240 


Lys Phe Ser Phe Met Arg Asp Trp Leu Gly His Val Arg Gly Gln Thr 
                245                 250                 255     


Gly Lys Asn Leu Phe Ala Val Ala Glu Tyr Trp Lys Asn Asp Leu Gly 
            260                 265                 270         


Ala Leu Glu Asn Tyr Leu Ser Lys Thr Asn Trp Thr Met Ser Ala Phe 
        275                 280                 285             


Asp Val Pro Leu His Tyr Asn Leu Tyr Gln Ala Ser Asn Ser Ser Gly 
    290                 295                 300                 


Asn Tyr Asp Met Arg Asn Leu Leu Asn Gly Thr Leu Val Gln Arg His 
305                 310                 315                 320 


Pro Ser His Ala Val Thr Phe Val Asp Asn His Asp Thr Gln Pro Gly 
                325                 330                 335     


Glu Ala Leu Glu Ser Phe Val Gln Gly Trp Phe Lys Pro Leu Ala Tyr 
            340                 345                 350         


Ala Thr Ile Leu Thr Arg Glu Gln Gly Tyr Pro Gln Val Phe Tyr Gly 
        355                 360                 365             


Asp Tyr Tyr Gly Ile Pro Ser Asp Gly Val Pro Ser Tyr Arg Gln Gln 
    370                 375                 380                 


Ile Asp Pro Leu Leu Lys Ala Arg Gln Gln Tyr Ala Tyr Gly Arg Gln 
385                 390                 395                 400 


His Asp Tyr Phe Asp His Trp Asp Val Ile Gly Trp Thr Arg Glu Gly 
                405                 410                 415     


Asn Ala Ser His Pro Asn Ser Gly Leu Ala Thr Ile Met Ser Asp Gly 
            420                 425                 430         


Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Arg Gln Lys Ala Gly Glu 
        435                 440                 445             


Val Trp His Asp Met Thr Gly Asn Arg Ser Gly Thr Val Thr Ile Asn 
    450                 455                 460                 


Gln Asp Gly Trp Gly His Phe Phe Val Asn Gly Gly Ser Val Ser Val 
465                 470                 475                 480 


Trp Val Lys Arg 
                


<210>  159
<211>  484
<212>  PRT
<213>  Artificail Sequence

<400>  159

His His Asp Gly Thr Asn Gly Thr Ile Met Gln Tyr Phe Glu Trp Asn 
1               5                   10                  15      


Val Pro Asn Asp Gly Gln His Trp Asn Arg Leu His Asn Asn Ala Gln 
            20                  25                  30          


Asn Leu Lys Asn Ala Gly Ile Thr Ala Ile Trp Ile Pro Pro Ala Trp 
        35                  40                  45              


Lys Gly Thr Ser Gln Asn Asp Val Gly Tyr Gly Ala Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Ala Glu Leu Glu Arg Ala Ile Arg Ser Leu Lys Ala Asn Gly 
                85                  90                  95      


Ile Gln Val Tyr Gly Asp Val Val Met Asp His Lys Gly Gly Ala Asp 
            100                 105                 110         


Gly Thr Glu Trp Val Asp Ala Val Glu Val Asn Pro Ser Asp Arg Asn 
        115                 120                 125             


Gln Glu Ile Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Val Asp Trp Asp Glu Ser Arg Lys Leu Ser Arg Ile 
                165                 170                 175     


Tyr Lys Phe Arg Gly Ile Gly Lys Ala Trp Asp Trp Glu Val Asp Thr 
            180                 185                 190         


Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Leu Asp Met Asp 
        195                 200                 205             


His Pro Glu Val Ile Asn Glu Leu Asn Arg Trp Gly Val Trp Tyr Ala 
    210                 215                 220                 


Asn Thr Leu Asn Leu Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile 
225                 230                 235                 240 


Lys Phe Ser Phe Met Arg Asp Trp Leu Gly His Val Arg Gly Gln Thr 
                245                 250                 255     


Gly Lys Asn Leu Phe Ala Val Ala Glu Tyr Trp Lys Asn Asp Leu Gly 
            260                 265                 270         


Ala Leu Glu Asn Tyr Leu Ser Lys Thr Asn Trp Thr Met Ser Ala Phe 
        275                 280                 285             


Asp Val Pro Leu His Tyr Asn Leu Tyr Gln Ala Ser Asn Ser Ser Gly 
    290                 295                 300                 


Asn Tyr Asp Met Arg Asn Leu Leu Asn Gly Thr Leu Val Gln Arg His 
305                 310                 315                 320 


Pro Ser His Ala Val Thr Phe Val Asp Asn His Asp Thr Gln Pro Gly 
                325                 330                 335     


Glu Ala Leu Glu Ser Phe Val Gln Gly Trp Phe Lys Pro Leu Ala Tyr 
            340                 345                 350         


Ala Thr Ile Leu Thr Arg Glu Gln Gly Tyr Pro Gln Val Phe Tyr Gly 
        355                 360                 365             


Asp Tyr Tyr Gly Ile Pro Ser Asp Gly Val Pro Ser Tyr Arg Gln Gln 
    370                 375                 380                 


Ile Asp Pro Leu Leu Lys Ala Arg Gln Gln Tyr Ala Tyr Gly Arg Gln 
385                 390                 395                 400 


His Asp Tyr Phe Asp His Trp Asp Val Ile Gly Trp Thr Arg Glu Gly 
                405                 410                 415     


Asn Ala Ser His Pro Asn Ser Gly Leu Ala Thr Ile Met Ser Asp Gly 
            420                 425                 430         


Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Arg Gln Lys Ala Gly Glu 
        435                 440                 445             


Val Trp His Asp Met Thr Gly Asn Arg Ser Gly Thr Val Thr Ile Asn 
    450                 455                 460                 


Gln Asp Gly Trp Gly His Phe Phe Val Asn Gly Gly Ser Val Ser Val 
465                 470                 475                 480 


Trp Val Lys Arg 
                


<210>  160
<211>  484
<212>  PRT
<213>  Artifical Sequence

<400>  160

His His Asp Gly Thr Asn Gly Thr Ile Met Gln Tyr Phe Glu Trp Asn 
1               5                   10                  15      


Val Pro Asn Asp Gly Gln His Trp Asn Arg Leu His Asn Asn Ala Gln 
            20                  25                  30          


Asn Leu Lys Asn Ala Gly Ile Thr Ala Ile Trp Ile Pro Pro Ala Trp 
        35                  40                  45              


Lys Gly Thr Ser Gln Asn Asp Val Gly Tyr Gly Ala Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Ala Glu Leu Glu Arg Ala Ile Arg Ser Leu Lys Ala Asn Gly 
                85                  90                  95      


Ile Gln Val Tyr Gly Asp Val Val Met Asn His Lys Ala Gly Ala Asp 
            100                 105                 110         


Gly Thr Glu Leu Val Asp Ala Val Glu Val Asn Pro Ser Asp Arg Asn 
        115                 120                 125             


Gln Glu Ile Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Glu Ser Arg Lys Leu Asn Arg Ile 
                165                 170                 175     


Tyr Lys Phe Arg Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Asp Thr 
            180                 185                 190         


Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Leu Asp Met Asp 
        195                 200                 205             


His Pro Glu Val Ile Asn Glu Leu Asn Arg Trp Gly Val Trp Tyr Ala 
    210                 215                 220                 


Asn Thr Leu Asn Leu Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile 
225                 230                 235                 240 


Lys Phe Ser Phe Met Arg Asp Trp Leu Gly His Val Arg Gly Gln Thr 
                245                 250                 255     


Gly Lys Asn Leu Phe Ala Val Ala Glu Tyr Trp Lys Asn Asp Leu Gly 
            260                 265                 270         


Ala Leu Glu Asn Tyr Leu Ser Lys Thr Asn Trp Thr Met Ser Ala Phe 
        275                 280                 285             


Asp Val Pro Leu His Tyr Asn Leu Tyr Gln Ala Ser Asn Ser Ser Gly 
    290                 295                 300                 


Asn Tyr Asp Met Arg Asn Leu Leu Asn Gly Thr Leu Val Gln Arg His 
305                 310                 315                 320 


Pro Ser His Ala Val Thr Phe Val Asp Asn His Asp Thr Gln Pro Gly 
                325                 330                 335     


Glu Ala Leu Glu Ser Phe Val Gln Gly Trp Phe Lys Pro Leu Ala Tyr 
            340                 345                 350         


Ala Thr Ile Leu Thr Arg Glu Gln Gly Tyr Pro Gln Val Phe Tyr Gly 
        355                 360                 365             


Asp Tyr Tyr Gly Ile Pro Ser Asp Gly Val Pro Ser Tyr Arg Gln Gln 
    370                 375                 380                 


Ile Asp Pro Leu Leu Lys Ala Arg Gln Gln Tyr Ala Tyr Gly Arg Gln 
385                 390                 395                 400 


His Asp Tyr Phe Asp His Trp Asp Val Ile Gly Trp Thr Arg Glu Gly 
                405                 410                 415     


Asn Ala Ser His Pro Asn Ser Gly Leu Ala Thr Ile Met Ser Asp Gly 
            420                 425                 430         


Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Arg Gln Lys Ala Gly Glu 
        435                 440                 445             


Val Trp His Asp Met Thr Gly Asn Arg Ser Gly Thr Val Thr Ile Asn 
    450                 455                 460                 


Gln Asp Gly Trp Gly His Phe Phe Val Asn Gly Gly Ser Val Ser Val 
465                 470                 475                 480 


Trp Val Lys Arg 
                


<210>  161
<211>  484
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  161

His His Asp Gly Thr Asn Gly Thr Ile Met Gln Tyr Phe Glu Trp Asn 
1               5                   10                  15      


Val Pro Asn Asp Gly Gln His Trp Asn Arg Leu His Asn Asn Ala Gln 
            20                  25                  30          


Asn Leu Lys Asn Ala Gly Ile Thr Ala Ile Trp Ile Pro Pro Ala Trp 
        35                  40                  45              


Lys Gly Thr Ser Gln Asn Asp Val Gly Tyr Gly Ala Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Ala Glu Leu Glu Arg Ala Ile Arg Ser Leu Lys Ala Asn Gly 
                85                  90                  95      


Ile Gln Val Tyr Gly Asp Val Val Met Asn His Lys Ala Gly Ala Asp 
            100                 105                 110         


Gly Thr Glu Phe Val Asp Ala Val Glu Val Asn Pro Ser Asn Arg Asn 
        115                 120                 125             


Gln Glu Thr Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Glu Ser Arg Lys Leu Asn Arg Val 
                165                 170                 175     


Tyr Lys Phe Arg Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Asp Thr 
            180                 185                 190         


Glu Asn Gly Asn Tyr Asp Tyr Leu Met Phe Ala Asp Leu Asp Met Asp 
        195                 200                 205             


His Pro Glu Val Ile Asn Glu Leu Asn Arg Trp Gly Val Trp Tyr Ala 
    210                 215                 220                 


Asn Thr Leu Asn Leu Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile 
225                 230                 235                 240 


Lys Phe Ser Phe Met Arg Asp Trp Leu Gly His Val Arg Gly Gln Thr 
                245                 250                 255     


Gly Lys Asn Leu Phe Ala Val Ala Glu Tyr Trp Lys Asn Asp Leu Gly 
            260                 265                 270         


Ala Leu Glu Asn Tyr Leu Ser Lys Thr Asn Trp Thr Met Ser Ala Phe 
        275                 280                 285             


Asp Val Pro Leu His Tyr Asn Leu Tyr Gln Ala Ser Asn Ser Ser Gly 
    290                 295                 300                 


Asn Tyr Asp Met Arg Asn Leu Leu Asn Gly Thr Leu Val Gln Arg His 
305                 310                 315                 320 


Pro Ser His Ala Val Thr Phe Val Asp Asn His Asp Thr Gln Pro Gly 
                325                 330                 335     


Glu Ala Leu Glu Ser Phe Val Gln Gly Trp Phe Lys Pro Leu Ala Tyr 
            340                 345                 350         


Ala Thr Ile Leu Thr Arg Glu Gln Gly Tyr Pro Gln Val Phe Tyr Gly 
        355                 360                 365             


Asp Tyr Tyr Gly Ile Pro Ser Asp Gly Val Pro Ser Tyr Arg Gln Gln 
    370                 375                 380                 


Ile Asp Pro Leu Leu Lys Ala Arg Gln Gln Tyr Ala Tyr Gly Arg Gln 
385                 390                 395                 400 


His Asp Tyr Phe Asp His Trp Asp Val Ile Gly Trp Thr Arg Glu Gly 
                405                 410                 415     


Asn Ala Ser His Pro Asn Ser Gly Leu Ala Thr Ile Met Ser Asp Gly 
            420                 425                 430         


Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Arg Gln Lys Ala Gly Glu 
        435                 440                 445             


Val Trp His Asp Met Thr Gly Asn Arg Ser Gly Thr Val Thr Ile Asn 
    450                 455                 460                 


Gln Asp Gly Trp Gly His Phe Phe Val Asn Gly Gly Ser Val Ser Val 
465                 470                 475                 480 


Trp Val Lys Arg 
                


<210>  162
<211>  483
<212>  PRT
<213>  Artifical Sequence

<400>  162

His His Asp Gly Thr Asn Gly Thr Ile Met Gln Tyr Phe Glu Trp Asn 
1               5                   10                  15      


Val Pro Asn Asp Gly Gln His Trp Asn Arg Leu His Asn Asn Ala Gln 
            20                  25                  30          


Asn Leu Lys Asn Ala Gly Ile Thr Ala Ile Trp Ile Pro Pro Ala Trp 
        35                  40                  45              


Lys Gly Thr Ser Gln Asn Asp Val Gly Tyr Gly Ala Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Ala Glu Leu Glu Arg Ala Ile Arg Ser Leu Lys Ala Asn Gly 
                85                  90                  95      


Ile Gln Val Tyr Gly Asp Val Val Met Asn His Lys Ala Gly Ala Asp 
            100                 105                 110         


Gly Thr Glu Phe Val Asp Ala Val Glu Val Asp Pro Ser Asn Arg Asn 
        115                 120                 125             


Gln Glu Thr Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Glu Ser Arg Lys Leu Asn Arg Ile 
                165                 170                 175     


Tyr Lys Phe Ser Thr Gly Lys Ala Trp Asp Trp Glu Val Asp Thr Glu 
            180                 185                 190         


Asn Gly Asn Tyr Asp Tyr Leu Met Phe Ala Asp Leu Asp Met Asp His 
        195                 200                 205             


Pro Glu Val Ile Asn Glu Leu Asn Arg Trp Gly Val Trp Tyr Ala Asn 
    210                 215                 220                 


Thr Leu Asn Leu Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile Lys 
225                 230                 235                 240 


Phe Ser Phe Met Arg Asp Trp Leu Gly His Val Arg Gly Gln Thr Gly 
                245                 250                 255     


Lys Asn Leu Phe Ala Val Ala Glu Tyr Trp Lys Asn Asp Leu Gly Ala 
            260                 265                 270         


Leu Glu Asn Tyr Leu Ser Lys Thr Asn Trp Thr Met Ser Ala Phe Asp 
        275                 280                 285             


Val Pro Leu His Tyr Asn Leu Tyr Gln Ala Ser Asn Ser Ser Gly Asn 
    290                 295                 300                 


Tyr Asp Met Arg Asn Leu Leu Asn Gly Thr Leu Val Gln Arg His Pro 
305                 310                 315                 320 


Ser His Ala Val Thr Phe Val Asp Asn His Asp Thr Gln Pro Gly Glu 
                325                 330                 335     


Ala Leu Glu Ser Phe Val Gln Gly Trp Phe Lys Pro Leu Ala Tyr Ala 
            340                 345                 350         


Thr Ile Leu Thr Arg Glu Gln Gly Tyr Pro Gln Val Phe Tyr Gly Asp 
        355                 360                 365             


Tyr Tyr Gly Ile Pro Ser Asp Gly Val Pro Ser Tyr Arg Gln Gln Ile 
    370                 375                 380                 


Asp Pro Leu Leu Lys Ala Arg Gln Gln Tyr Ala Tyr Gly Arg Gln His 
385                 390                 395                 400 


Asp Tyr Phe Asp His Trp Asp Val Ile Gly Trp Thr Arg Glu Gly Asn 
                405                 410                 415     


Ala Ser His Pro Asn Ser Gly Leu Ala Thr Ile Met Ser Asp Gly Pro 
            420                 425                 430         


Gly Gly Ser Lys Trp Met Tyr Val Gly Arg Gln Lys Ala Gly Glu Val 
        435                 440                 445             


Trp His Asp Met Thr Gly Asn Arg Ser Gly Thr Val Thr Ile Asn Gln 
    450                 455                 460                 


Asp Gly Trp Gly His Phe Phe Val Asn Gly Gly Ser Val Ser Val Trp 
465                 470                 475                 480 


Val Lys Arg 
            


<210>  163
<211>  484
<212>  PRT
<213>  Artifical Sequence

<400>  163

His His Asp Gly Thr Asn Gly Thr Ile Met Gln Tyr Phe Glu Trp Asn 
1               5                   10                  15      


Val Pro Asn Asp Gly Gln His Trp Asn Arg Leu His Asn Asn Ala Gln 
            20                  25                  30          


Asn Leu Lys Asn Ala Gly Ile Thr Ala Ile Trp Ile Pro Pro Ala Trp 
        35                  40                  45              


Lys Gly Thr Ser Gln Asn Asp Val Gly Tyr Gly Ala Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Ala Glu Leu Glu Arg Ala Ile Arg Ser Leu Lys Ala Asn Gly 
                85                  90                  95      


Ile Gln Val Tyr Gly Asp Val Val Met Asn His Lys Ala Gly Ala Asp 
            100                 105                 110         


Gly Thr Glu Phe Val Asp Ala Val Glu Val Asn Pro Ser Asn Arg Asn 
        115                 120                 125             


Gln Glu Thr Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Glu Ser Arg Lys Leu Asn Arg Ile 
                165                 170                 175     


Tyr Lys Phe Arg Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Asp Thr 
            180                 185                 190         


Glu Asn Gly Asn Tyr Asp Tyr Leu Met Phe Ala Asp Leu Asp Met Asp 
        195                 200                 205             


His Pro Glu Val Ile Asn Glu Leu Asn Arg Trp Gly Val Trp Tyr Ala 
    210                 215                 220                 


Asn Thr Leu Asn Leu Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile 
225                 230                 235                 240 


Lys Phe Ser Phe Met Arg Asp Trp Leu Gly His Val Arg Gly Gln Thr 
                245                 250                 255     


Gly Lys Asn Leu Phe Ala Val Ala Glu Tyr Trp Lys Asn Asp Leu Gly 
            260                 265                 270         


Ala Leu Glu Asn Tyr Leu Ser Lys Thr Asn Trp Thr Met Ser Ala Phe 
        275                 280                 285             


Asp Val Pro Leu His Tyr Asn Leu Tyr Gln Ala Ser Asn Ser Ser Gly 
    290                 295                 300                 


Asn Tyr Asp Met Arg Asn Leu Leu Asn Gly Thr Leu Val Gln Arg His 
305                 310                 315                 320 


Pro Ser His Ala Val Thr Phe Val Asp Asn His Asp Thr Gln Pro Gly 
                325                 330                 335     


Glu Ala Leu Glu Ser Phe Val Gln Gly Trp Phe Lys Pro Leu Ala Tyr 
            340                 345                 350         


Ala Thr Ile Leu Thr Arg Glu Gln Gly Tyr Pro Gln Val Phe Tyr Gly 
        355                 360                 365             


Asp Tyr Tyr Gly Ile Pro Ser Asp Gly Val Pro Ser Tyr Arg Gln Gln 
    370                 375                 380                 


Ile Asp Pro Leu Leu Lys Ala Arg Gln Gln Tyr Ala Tyr Gly Arg Gln 
385                 390                 395                 400 


His Asp Tyr Phe Asp His Trp Asp Val Ile Gly Trp Thr Arg Glu Gly 
                405                 410                 415     


Asn Ala Ser His Pro Asn Ser Gly Leu Ala Thr Ile Met Ser Asp Gly 
            420                 425                 430         


Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Arg Gln Lys Ala Gly Glu 
        435                 440                 445             


Val Trp His Asp Met Thr Gly Asn Arg Ser Gly Thr Val Thr Ile Asn 
    450                 455                 460                 


Gln Asp Gly Trp Gly His Phe Phe Val Asn Gly Gly Ser Val Ser Val 
465                 470                 475                 480 


Trp Val Lys Arg 
                


<210>  164
<211>  484
<212>  PRT
<213>  Artifical Sequence

<400>  164

His His Asp Gly Thr Asn Gly Thr Ile Met Gln Tyr Phe Glu Trp Asn 
1               5                   10                  15      


Val Pro Asn Asp Gly Gln His Trp Asn Arg Leu His Asn Asn Ala Gln 
            20                  25                  30          


Asn Leu Lys Asn Ala Gly Ile Thr Ala Ile Trp Ile Pro Pro Ala Trp 
        35                  40                  45              


Lys Gly Thr Ser Gln Asn Asp Val Gly Tyr Gly Ala Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Ala Glu Leu Glu Arg Ala Ile Arg Ser Leu Lys Ala Asn Gly 
                85                  90                  95      


Ile Gln Val Tyr Gly Asp Val Val Met Asn His Lys Ala Gly Ala Asp 
            100                 105                 110         


Ala Thr Glu Trp Val Asp Ala Val Glu Val Asn Pro Ser Asn Arg Asn 
        115                 120                 125             


Gln Glu Val Ser Gly Thr Tyr Lys Ile Gln Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Gln Ser Arg Gln Leu Asn Arg Ile 
                165                 170                 175     


Tyr Lys Phe Arg Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Asp Thr 
            180                 185                 190         


Glu Asn Gly Asn Tyr Asp Tyr Leu Met Phe Ala Asp Leu Asp Met Asp 
        195                 200                 205             


His Pro Glu Val Ile Asn Glu Leu Asn Arg Trp Gly Val Trp Tyr Ala 
    210                 215                 220                 


Asn Thr Leu Asn Leu Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile 
225                 230                 235                 240 


Lys Phe Ser Phe Met Arg Asp Trp Leu Gly His Val Arg Gly Gln Thr 
                245                 250                 255     


Gly Lys Asn Leu Phe Ala Val Ala Glu Tyr Trp Lys Asn Asp Leu Gly 
            260                 265                 270         


Ala Leu Glu Asn Tyr Leu Ser Lys Thr Asn Trp Thr Met Ser Ala Phe 
        275                 280                 285             


Asp Val Pro Leu His Tyr Asn Leu Tyr Gln Ala Ser Asn Ser Ser Gly 
    290                 295                 300                 


Asn Tyr Asp Met Arg Asn Leu Leu Asn Gly Thr Leu Val Gln Arg His 
305                 310                 315                 320 


Pro Ser His Ala Val Thr Phe Val Asp Asn His Asp Thr Gln Pro Gly 
                325                 330                 335     


Glu Ala Leu Glu Ser Phe Val Gln Gly Trp Phe Lys Pro Leu Ala Tyr 
            340                 345                 350         


Ala Thr Ile Leu Thr Arg Glu Gln Gly Tyr Pro Gln Val Phe Tyr Gly 
        355                 360                 365             


Asp Tyr Tyr Gly Ile Pro Ser Asp Gly Val Pro Ser Tyr Arg Gln Gln 
    370                 375                 380                 


Ile Asp Pro Leu Leu Lys Ala Arg Gln Gln Tyr Ala Tyr Gly Arg Gln 
385                 390                 395                 400 


His Asp Tyr Phe Asp His Trp Asp Val Ile Gly Trp Thr Arg Glu Gly 
                405                 410                 415     


Asn Ala Ser His Pro Asn Ser Gly Leu Ala Thr Ile Met Ser Asp Gly 
            420                 425                 430         


Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Arg Gln Lys Ala Gly Glu 
        435                 440                 445             


Val Trp His Asp Met Thr Gly Asn Arg Ser Gly Thr Val Thr Ile Asn 
    450                 455                 460                 


Gln Asp Gly Trp Gly His Phe Phe Val Asn Gly Gly Ser Val Ser Val 
465                 470                 475                 480 


Trp Val Lys Arg 
                


<210>  165
<211>  484
<212>  PRT
<213>  Artifical Sequence

<400>  165

His His Asp Gly Thr Asn Gly Thr Ile Met Gln Tyr Phe Glu Trp Asn 
1               5                   10                  15      


Val Pro Asn Asp Gly Gln His Trp Asn Arg Leu His Asn Asn Ala Gln 
            20                  25                  30          


Asn Leu Lys Asn Ala Gly Ile Thr Ala Ile Trp Ile Pro Pro Ala Trp 
        35                  40                  45              


Lys Gly Thr Ser Gln Asn Asp Val Gly Tyr Gly Ala Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Ala Glu Leu Glu Arg Ala Ile Arg Ser Leu Lys Ala Asn Gly 
                85                  90                  95      


Ile Gln Val Tyr Gly Asp Val Val Met Asn His Lys Ala Gly Ala Asp 
            100                 105                 110         


Ser Thr Glu Trp Val Asp Ala Val Glu Val Asn Pro Ser Asn Arg Asn 
        115                 120                 125             


Gln Glu Thr Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Glu Ser Arg Lys Leu Asn Arg Ile 
                165                 170                 175     


Tyr Lys Phe Arg Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Asp Thr 
            180                 185                 190         


Glu Asn Gly Asn Tyr Asp Tyr Leu Met Phe Ala Asp Leu Asp Met Asp 
        195                 200                 205             


His Pro Glu Val Ile Asn Glu Leu Asn Arg Trp Gly Val Trp Tyr Ala 
    210                 215                 220                 


Asn Thr Leu Asn Leu Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile 
225                 230                 235                 240 


Lys Phe Ser Phe Met Arg Asp Trp Leu Gly His Val Arg Gly Gln Thr 
                245                 250                 255     


Gly Lys Asn Leu Phe Ala Val Ala Glu Tyr Trp Lys Asn Asp Leu Gly 
            260                 265                 270         


Ala Leu Glu Asn Tyr Leu Ser Lys Thr Asn Trp Thr Met Ser Ala Phe 
        275                 280                 285             


Asp Val Pro Leu His Tyr Asn Leu Tyr Gln Ala Ser Asn Ser Ser Gly 
    290                 295                 300                 


Asn Tyr Asp Met Arg Asn Leu Leu Asn Gly Thr Leu Val Gln Arg His 
305                 310                 315                 320 


Pro Ser His Ala Val Thr Phe Val Asp Asn His Asp Thr Gln Pro Gly 
                325                 330                 335     


Glu Ala Leu Glu Ser Phe Val Gln Gly Trp Phe Lys Pro Leu Ala Tyr 
            340                 345                 350         


Ala Thr Ile Leu Thr Arg Glu Gln Gly Tyr Pro Gln Val Phe Tyr Gly 
        355                 360                 365             


Asp Tyr Tyr Gly Ile Pro Ser Asp Gly Val Pro Ser Tyr Arg Gln Gln 
    370                 375                 380                 


Ile Asp Pro Leu Leu Lys Ala Arg Gln Gln Tyr Ala Tyr Gly Arg Gln 
385                 390                 395                 400 


His Asp Tyr Phe Asp His Trp Asp Val Ile Gly Trp Thr Arg Glu Gly 
                405                 410                 415     


Asn Ala Ser His Pro Asn Ser Gly Leu Ala Thr Ile Met Ser Asp Gly 
            420                 425                 430         


Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Arg Gln Lys Ala Gly Glu 
        435                 440                 445             


Val Trp His Asp Met Thr Gly Asn Arg Ser Gly Thr Val Thr Ile Asn 
    450                 455                 460                 


Gln Asp Gly Trp Gly His Phe Phe Val Asn Gly Gly Ser Val Ser Val 
465                 470                 475                 480 


Trp Val Lys Arg 
                


<210>  166
<211>  485
<212>  PRT
<213>  Artifical Sequence

<400>  166

His His Asp Gly Thr Asn Gly Thr Ile Met Gln Tyr Phe Glu Trp Asn 
1               5                   10                  15      


Val Pro Asn Asp Gly Gln His Trp Asn Arg Leu His Asn Asn Ala Gln 
            20                  25                  30          


Asn Leu Lys Asn Ala Gly Ile Thr Ala Ile Trp Ile Pro Pro Ala Trp 
        35                  40                  45              


Lys Gly Thr Ser Gln Asn Asp Val Gly Tyr Gly Ala Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Ala Glu Leu Glu Arg Ala Ile Arg Ser Leu Lys Ala Asn Gly 
                85                  90                  95      


Ile Gln Val Tyr Gly Asp Val Val Met Asn His Lys Gly Gly Ala Asp 
            100                 105                 110         


Ala Thr Glu Asn Val Leu Ala Val Glu Val Asn Pro Asn Asn Arg Asn 
        115                 120                 125             


Gln Glu Ile Ser Gly Asp Tyr Thr Ile Glu Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Asp Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Val Asp Trp Asp Gln Ser Arg Gln Phe Gln Asn Arg 
                165                 170                 175     


Ile Tyr Lys Phe Arg Gly Asp Gly Lys Ala Trp Asp Trp Glu Val Asp 
            180                 185                 190         


Ser Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Val Asp Met 
        195                 200                 205             


Asp His Pro Glu Val Ile Asn Glu Leu Asn Arg Trp Gly Val Trp Tyr 
    210                 215                 220                 


Ala Asn Thr Leu Asn Leu Asp Gly Phe Arg Leu Asp Ala Val Lys His 
225                 230                 235                 240 


Ile Lys Phe Ser Phe Met Arg Asp Trp Leu Gly His Val Arg Gly Gln 
                245                 250                 255     


Thr Gly Lys Asn Leu Phe Ala Val Ala Glu Tyr Trp Lys Asn Asp Leu 
            260                 265                 270         


Gly Ala Leu Glu Asn Tyr Leu Ser Lys Thr Asn Trp Thr Met Ser Ala 
        275                 280                 285             


Phe Asp Val Pro Leu His Tyr Asn Leu Tyr Gln Ala Ser Asn Ser Ser 
    290                 295                 300                 


Gly Asn Tyr Asp Met Arg Asn Leu Leu Asn Gly Thr Leu Val Gln Arg 
305                 310                 315                 320 


His Pro Ser His Ala Val Thr Phe Val Asp Asn His Asp Thr Gln Pro 
                325                 330                 335     


Gly Glu Ala Leu Glu Ser Phe Val Gln Gly Trp Phe Lys Pro Leu Ala 
            340                 345                 350         


Tyr Ala Thr Ile Leu Thr Arg Glu Gln Gly Tyr Pro Gln Val Phe Tyr 
        355                 360                 365             


Gly Asp Tyr Tyr Gly Ile Pro Ser Asp Gly Val Pro Ser Tyr Arg Gln 
    370                 375                 380                 


Gln Ile Asp Pro Leu Leu Lys Ala Arg Gln Gln Tyr Ala Tyr Gly Arg 
385                 390                 395                 400 


Gln His Asp Tyr Phe Asp His Trp Asp Val Ile Gly Trp Thr Arg Glu 
                405                 410                 415     


Gly Asn Ala Ser His Pro Asn Ser Gly Leu Ala Thr Ile Met Ser Asp 
            420                 425                 430         


Gly Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Arg Gln Lys Ala Gly 
        435                 440                 445             


Glu Val Trp His Asp Met Thr Gly Asn Arg Ser Gly Thr Val Thr Ile 
    450                 455                 460                 


Asn Gln Asp Gly Trp Gly His Phe Phe Val Asn Gly Gly Ser Val Ser 
465                 470                 475                 480 


Val Trp Val Lys Arg 
                485 


<210>  167
<211>  485
<212>  PRT
<213>  Artifical Sequence

<400>  167

His His Asp Gly Thr Asn Gly Thr Ile Met Gln Tyr Phe Glu Trp Asn 
1               5                   10                  15      


Val Pro Asn Asp Gly Gln His Trp Asn Arg Leu His Asn Asn Ala Gln 
            20                  25                  30          


Asn Leu Lys Asn Ala Gly Ile Thr Ala Ile Trp Ile Pro Pro Ala Trp 
        35                  40                  45              


Lys Gly Thr Ser Gln Asn Asp Val Gly Tyr Gly Ala Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Ala Glu Leu Glu Arg Ala Ile Arg Ser Leu Lys Ala Asn Gly 
                85                  90                  95      


Ile Gln Val Tyr Gly Asp Val Val Met Asn His Lys Gly Gly Ala Asp 
            100                 105                 110         


Ala Thr Glu Met Val Arg Ala Val Glu Val Asn Pro Asn Asn Arg Asn 
        115                 120                 125             


Gln Glu Val Ser Gly Glu Tyr Thr Ile Glu Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr His Ser Asn Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Val Asp Trp Asp Gln Ser Arg Lys Leu Asn Asn Arg 
                165                 170                 175     


Ile Tyr Lys Phe Arg Gly Asp Gly Lys Gly Trp Asp Trp Glu Val Asp 
            180                 185                 190         


Thr Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Ile Asp Met 
        195                 200                 205             


Asp His Pro Glu Val Ile Asn Glu Leu Asn Arg Trp Gly Val Trp Tyr 
    210                 215                 220                 


Ala Asn Thr Leu Asn Leu Asp Gly Phe Arg Leu Asp Ala Val Lys His 
225                 230                 235                 240 


Ile Lys Phe Ser Phe Met Arg Asp Trp Leu Gly His Val Arg Gly Gln 
                245                 250                 255     


Thr Gly Lys Asn Leu Phe Ala Val Ala Glu Tyr Trp Lys Asn Asp Leu 
            260                 265                 270         


Gly Ala Leu Glu Asn Tyr Leu Ser Lys Thr Asn Trp Thr Met Ser Ala 
        275                 280                 285             


Phe Asp Val Pro Leu His Tyr Asn Leu Tyr Gln Ala Ser Asn Ser Ser 
    290                 295                 300                 


Gly Asn Tyr Asp Met Arg Asn Leu Leu Asn Gly Thr Leu Val Gln Arg 
305                 310                 315                 320 


His Pro Ser His Ala Val Thr Phe Val Asp Asn His Asp Thr Gln Pro 
                325                 330                 335     


Gly Glu Ala Leu Glu Ser Phe Val Gln Gly Trp Phe Lys Pro Leu Ala 
            340                 345                 350         


Tyr Ala Thr Ile Leu Thr Arg Glu Gln Gly Tyr Pro Gln Val Phe Tyr 
        355                 360                 365             


Gly Asp Tyr Tyr Gly Ile Pro Ser Asp Gly Val Pro Ser Tyr Arg Gln 
    370                 375                 380                 


Gln Ile Asp Pro Leu Leu Lys Ala Arg Gln Gln Tyr Ala Tyr Gly Arg 
385                 390                 395                 400 


Gln His Asp Tyr Phe Asp His Trp Asp Val Ile Gly Trp Thr Arg Glu 
                405                 410                 415     


Gly Asn Ala Ser His Pro Asn Ser Gly Leu Ala Thr Ile Met Ser Asp 
            420                 425                 430         


Gly Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Arg Gln Lys Ala Gly 
        435                 440                 445             


Glu Val Trp His Asp Met Thr Gly Asn Arg Ser Gly Thr Val Thr Ile 
    450                 455                 460                 


Asn Gln Asp Gly Trp Gly His Phe Phe Val Asn Gly Gly Ser Val Ser 
465                 470                 475                 480 


Val Trp Val Lys Arg 
                485 


<210>  168
<211>  485
<212>  PRT
<213>  Artifical Sequence

<400>  168

His His Asp Gly Thr Asn Gly Thr Ile Met Gln Tyr Phe Glu Trp Asn 
1               5                   10                  15      


Val Pro Asn Asp Gly Gln His Trp Asn Arg Leu His Asn Asn Ala Gln 
            20                  25                  30          


Asn Leu Lys Asn Ala Gly Ile Thr Ala Ile Trp Ile Pro Pro Ala Trp 
        35                  40                  45              


Lys Gly Thr Ser Gln Asn Asp Val Gly Tyr Gly Ala Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Ala Glu Leu Glu Arg Ala Ile Arg Ser Leu Lys Ala Asn Gly 
                85                  90                  95      


Ile Gln Val Tyr Gly Asp Val Val Met Asn His Lys Gly Gly Ala Asp 
            100                 105                 110         


Ala Thr Glu Met Val Arg Ala Val Glu Val Asn Pro Asn Asn Arg Asn 
        115                 120                 125             


Gln Glu Val Thr Gly Glu Tyr Thr Ile Glu Ala Trp Thr Arg Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr His Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Val Asp Trp Asp Gln Ser Arg Arg Leu Asn Asn Arg 
                165                 170                 175     


Ile Tyr Lys Phe Arg Gly His Gly Lys Ala Trp Asp Trp Glu Val Asp 
            180                 185                 190         


Thr Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Ile Asp Met 
        195                 200                 205             


Asp His Pro Glu Val Ile Asn Glu Leu Asn Arg Trp Gly Val Trp Tyr 
    210                 215                 220                 


Ala Asn Thr Leu Asn Leu Asp Gly Phe Arg Leu Asp Ala Val Lys His 
225                 230                 235                 240 


Ile Lys Phe Ser Phe Met Arg Asp Trp Leu Gly His Val Arg Gly Gln 
                245                 250                 255     


Thr Gly Lys Asn Leu Phe Ala Val Ala Glu Tyr Trp Lys Asn Asp Leu 
            260                 265                 270         


Gly Ala Leu Glu Asn Tyr Leu Ser Lys Thr Asn Trp Thr Met Ser Ala 
        275                 280                 285             


Phe Asp Val Pro Leu His Tyr Asn Leu Tyr Gln Ala Ser Asn Ser Ser 
    290                 295                 300                 


Gly Asn Tyr Asp Met Arg Asn Leu Leu Asn Gly Thr Leu Val Gln Arg 
305                 310                 315                 320 


His Pro Ser His Ala Val Thr Phe Val Asp Asn His Asp Thr Gln Pro 
                325                 330                 335     


Gly Glu Ala Leu Glu Ser Phe Val Gln Gly Trp Phe Lys Pro Leu Ala 
            340                 345                 350         


Tyr Ala Thr Ile Leu Thr Arg Glu Gln Gly Tyr Pro Gln Val Phe Tyr 
        355                 360                 365             


Gly Asp Tyr Tyr Gly Ile Pro Ser Asp Gly Val Pro Ser Tyr Arg Gln 
    370                 375                 380                 


Gln Ile Asp Pro Leu Leu Lys Ala Arg Gln Gln Tyr Ala Tyr Gly Arg 
385                 390                 395                 400 


Gln His Asp Tyr Phe Asp His Trp Asp Val Ile Gly Trp Thr Arg Glu 
                405                 410                 415     


Gly Asn Ala Ser His Pro Asn Ser Gly Leu Ala Thr Ile Met Ser Asp 
            420                 425                 430         


Gly Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Arg Gln Lys Ala Gly 
        435                 440                 445             


Glu Val Trp His Asp Met Thr Gly Asn Arg Ser Gly Thr Val Thr Ile 
    450                 455                 460                 


Asn Gln Asp Gly Trp Gly His Phe Phe Val Asn Gly Gly Ser Val Ser 
465                 470                 475                 480 


Val Trp Val Lys Arg 
                485 


<210>  169
<211>  485
<212>  PRT
<213>  Artifical Sequence

<400>  169

His His Asn Gly Thr Asn Gly Thr Met Met Gln Tyr Phe Glu Trp His 
1               5                   10                  15      


Leu Pro Asn Asp Gly Asn His Trp Asn Arg Leu Arg Asp Asp Ala Ser 
            20                  25                  30          


Asn Leu Arg Asn Arg Gly Ile Thr Ala Ile Trp Ile Pro Pro Ala Trp 
        35                  40                  45              


Lys Gly Thr Ser Gln Asn Asp Val Gly Tyr Gly Ala Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Arg Ser Gln Leu Glu Ser Ala Ile His Ala Leu Lys Asn Asn Gly 
                85                  90                  95      


Val Gln Val Tyr Gly Asp Val Val Met Asn His Arg Met Gly Ala Asp 
            100                 105                 110         


Ala Thr Glu Thr Ile Ser Ala Val Glu Val Asn Pro Ser Asn Arg Asn 
        115                 120                 125             


Gln Val Thr Ser Gly Ala Tyr Asn Ile Ser Ala Trp Thr Asp Phe Glu 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp His Ser Tyr 
145                 150                 155                 160 


Tyr Phe Asp Gly Val Asp Trp Asp Gln Ser Arg Gln Leu Ser Gly Lys 
                165                 170                 175     


Ile Tyr Gln Ile Gln Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Asp 
            180                 185                 190         


Ser Glu Asn Gly Asn Tyr Asp Tyr Leu Met Gly Ala Asp Ile Asp Met 
        195                 200                 205             


Asp His Pro Glu Val Val Asn Glu Leu Arg Arg Trp Gly Glu Trp Tyr 
    210                 215                 220                 


Thr Asn Thr Leu Asn Leu Asp Gly Phe Arg Ile Asp Ala Val Lys His 
225                 230                 235                 240 


Ile Lys Tyr Ser Phe Thr Arg Asp Trp Leu Thr His Val Arg Asn Ala 
                245                 250                 255     


Thr Gly Lys Glu Met Phe Ala Val Ala Glu Phe Trp Lys Asn Asp Leu 
            260                 265                 270         


Gly Ala Leu Glu Asn Tyr Leu Asn Lys Thr Asn Trp Asn His Ser Val 
        275                 280                 285             


Phe Asp Val Pro Leu His Tyr Asn Leu Tyr Asn Ala Ser Asn Ser Gly 
    290                 295                 300                 


Gly Asn Tyr Asp Met Ala Lys Leu Leu Asn Gly Thr Val Val Gln Lys 
305                 310                 315                 320 


His Pro Met His Ala Val Thr Phe Val Asp Asn His Asp Ser Gln Pro 
                325                 330                 335     


Gly Glu Ser Leu Glu Ser Phe Val Gln Glu Trp Phe Lys Pro Leu Ala 
            340                 345                 350         


Tyr Ala Leu Ile Leu Thr Arg Glu Gln Gly Tyr Pro Ser Val Phe Tyr 
        355                 360                 365             


Gly Asp Tyr Tyr Gly Ile Pro Thr His Ser Val Pro Ala Met Lys Ala 
    370                 375                 380                 


Lys Ile Asp Pro Ile Leu Glu Ala Arg Gln Asn Phe Ala Tyr Gly Thr 
385                 390                 395                 400 


Gln His Asp Tyr Phe Asp His His Asn Ile Ile Gly Trp Thr Arg Glu 
                405                 410                 415     


Gly Asn Thr Thr His Pro Asn Ser Gly Leu Ala Thr Ile Met Ser Asp 
            420                 425                 430         


Gly Pro Gly Gly Glu Lys Trp Met Tyr Val Gly Gln Asn Lys Ala Gly 
        435                 440                 445             


Gln Val Trp His Asp Ile Thr Gly Asn Lys Pro Gly Thr Val Thr Ile 
    450                 455                 460                 


Asn Ala Asp Gly Trp Ala Asn Phe Ser Val Asn Gly Gly Ser Val Ser 
465                 470                 475                 480 


Ile Trp Val Lys Arg 
                485 


<210>  170
<211>  485
<212>  PRT
<213>  Artifical Sequence

<400>  170

His His Asn Gly Thr Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr 
1               5                   10                  15      


Leu Pro Asn Asp Gly Asn His Trp Asn Arg Leu Arg Ser Asp Ala Ser 
            20                  25                  30          


Asn Leu Lys Asp Lys Gly Ile Ser Ala Val Trp Ile Pro Pro Ala Trp 
        35                  40                  45              


Lys Gly Ala Ser Gln Asn Asp Val Gly Tyr Gly Ala Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Ile Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Arg Asn Gln Leu Gln Ala Ala Val Asn Ala Leu Lys Ser Asn Gly 
                85                  90                  95      


Ile Gln Val Tyr Gly Asp Val Val Met Asn His Arg Met Gly Ala Asp 
            100                 105                 110         


Ala Thr Glu Thr Ile Ser Ala Val Glu Val Asn Pro Ser Asn Arg Asn 
        115                 120                 125             


Gln Val Thr Ser Gly Ala Tyr Asn Ile Ser Ala Trp Thr Asp Phe Glu 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp His Ser Tyr 
145                 150                 155                 160 


Tyr Phe Asp Gly Val Asp Trp Asp Gln Ser Arg Gln Leu Ser Gly Lys 
                165                 170                 175     


Ile Tyr Gln Ile Gln Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Asp 
            180                 185                 190         


Ser Glu Asn Gly Asn Tyr Asp Tyr Leu Met Gly Ala Asp Ile Asp Met 
        195                 200                 205             


Asp His Pro Glu Val Val Asn Glu Leu Arg Asn Trp Gly Val Trp Tyr 
    210                 215                 220                 


Thr Asn Thr Leu Gly Leu Asp Gly Phe Arg Ile Asp Ala Val Lys His 
225                 230                 235                 240 


Ile Lys Tyr Ser Phe Thr Arg Asp Trp Ile Asn His Val Arg Ser Ala 
                245                 250                 255     


Thr Gly Lys Asn Met Phe Ala Val Ala Glu Phe Trp Lys Asn Asp Leu 
            260                 265                 270         


Gly Ala Ile Glu Asn Tyr Leu Asn Lys Thr Asn Trp Asn His Ser Val 
        275                 280                 285             


Phe Asp Val Pro Leu His Tyr Asn Leu Tyr Asn Ala Ser Lys Ser Gly 
    290                 295                 300                 


Gly Asn Tyr Asp Met Arg Gln Ile Phe Asn Gly Thr Val Val Gln Arg 
305                 310                 315                 320 


His Pro Met His Ala Val Thr Phe Val Asp Asn His Asp Ser Gln Pro 
                325                 330                 335     


Glu Glu Ala Leu Glu Ser Phe Val Glu Glu Trp Phe Lys Pro Leu Ala 
            340                 345                 350         


Tyr Ala Leu Thr Leu Thr Arg Glu Gln Gly Tyr Pro Ser Val Phe Tyr 
        355                 360                 365             


Gly Asp Tyr Tyr Gly Ile Pro Thr His Gly Val Pro Ala Met Lys Ser 
    370                 375                 380                 


Lys Ile Asp Pro Ile Leu Glu Ala Arg Gln Lys Tyr Ala Tyr Gly Arg 
385                 390                 395                 400 


Gln Asn Asp Tyr Leu Asp His His Asn Ile Ile Gly Trp Thr Arg Glu 
                405                 410                 415     


Gly Asn Thr Ala His Pro Asn Ser Gly Leu Ala Thr Ile Met Ser Asp 
            420                 425                 430         


Gly Ala Gly Gly Asn Lys Trp Met Phe Val Gly Arg Asn Lys Ala Gly 
        435                 440                 445             


Gln Val Trp Thr Asp Ile Thr Gly Asn Arg Ala Gly Thr Val Thr Ile 
    450                 455                 460                 


Asn Ala Asp Gly Trp Gly Asn Phe Ser Val Asn Gly Gly Ser Val Ser 
465                 470                 475                 480 


Ile Trp Val Asn Lys 
                485 


<210>  171
<211>  484
<212>  PRT
<213>  Artifiical Sequence

<400>  171

His His Asn Gly Thr Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr 
1               5                   10                  15      


Leu Pro Asn Asp Gly Asn His Trp Asn Arg Leu Arg Ser Asp Ala Ser 
            20                  25                  30          


Asn Leu Lys Asp Lys Gly Ile Ser Ala Val Trp Ile Pro Pro Ala Trp 
        35                  40                  45              


Lys Gly Ala Ser Gln Asn Asp Val Gly Tyr Gly Ala Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Ile Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Arg Asn Gln Leu Gln Ala Ala Val Asn Ala Leu Lys Ser Asn Gly 
                85                  90                  95      


Ile Gln Val Tyr Gly Asp Val Val Met Asn His Lys Ala Gly Ala Asp 
            100                 105                 110         


Ala Thr Glu Asp Val Thr Ala Val Glu Val Asn Pro Ala Asn Arg Asn 
        115                 120                 125             


Gln Glu Thr Ser Glu Glu Tyr Gln Ile Lys Ala Trp Thr Asp Phe Arg 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Asp Phe Lys Trp His Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Ala Asp Trp Asp Glu Ser Arg Lys Ile Ser Arg Ile 
                165                 170                 175     


Phe Lys Phe Arg Gly Glu Gly Lys Ala Trp Asp Trp Glu Val Ser Ser 
            180                 185                 190         


Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Val Asp Met Asp 
        195                 200                 205             


His Pro Glu Val Val Asn Glu Leu Arg Asn Trp Gly Val Trp Tyr Thr 
    210                 215                 220                 


Asn Thr Leu Gly Leu Asp Gly Phe Arg Ile Asp Ala Val Lys His Ile 
225                 230                 235                 240 


Lys Tyr Ser Phe Thr Arg Asp Trp Ile Asn His Val Arg Ser Ala Thr 
                245                 250                 255     


Gly Lys Asn Met Phe Ala Val Ala Glu Phe Trp Lys Asn Asp Leu Gly 
            260                 265                 270         


Ala Ile Glu Asn Tyr Leu Asn Lys Thr Asn Trp Asn His Ser Val Phe 
        275                 280                 285             


Asp Val Pro Leu His Tyr Asn Leu Tyr Asn Ala Ser Lys Ser Gly Gly 
    290                 295                 300                 


Asn Tyr Asp Met Arg Gln Ile Phe Asn Gly Thr Val Val Gln Arg His 
305                 310                 315                 320 


Pro Met His Ala Val Thr Phe Val Asp Asn His Asp Ser Gln Pro Glu 
                325                 330                 335     


Glu Ala Leu Glu Ser Phe Val Glu Glu Trp Phe Lys Pro Leu Ala Tyr 
            340                 345                 350         


Ala Leu Thr Leu Thr Arg Glu Gln Gly Tyr Pro Ser Val Phe Tyr Gly 
        355                 360                 365             


Asp Tyr Tyr Gly Ile Pro Thr His Gly Val Pro Ala Met Lys Ser Lys 
    370                 375                 380                 


Ile Asp Pro Ile Leu Glu Ala Arg Gln Lys Tyr Ala Tyr Gly Arg Gln 
385                 390                 395                 400 


Asn Asp Tyr Leu Asp His His Asn Ile Ile Gly Trp Thr Arg Glu Gly 
                405                 410                 415     


Asn Thr Ala His Pro Asn Ser Gly Leu Ala Thr Ile Met Ser Asp Gly 
            420                 425                 430         


Ala Gly Gly Asn Lys Trp Met Phe Val Gly Arg Asn Lys Ala Gly Gln 
        435                 440                 445             


Val Trp Thr Asp Ile Thr Gly Asn Arg Ala Gly Thr Val Thr Ile Asn 
    450                 455                 460                 


Ala Asp Gly Trp Gly Asn Phe Ser Val Asn Gly Gly Ser Val Ser Ile 
465                 470                 475                 480 


Trp Val Asn Lys 
                


<210>  172
<211>  482
<212>  PRT
<213>  Artifical Sequence

<400>  172

His His Asn Gly Thr Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr 
1               5                   10                  15      


Leu Pro Asn Asp Gly Asn His Trp Asn Arg Leu Arg Ser Asp Ala Ser 
            20                  25                  30          


Asn Leu Lys Asp Lys Gly Ile Ser Ala Val Trp Ile Pro Pro Ala Trp 
        35                  40                  45              


Lys Gly Ala Ser Gln Asn Asp Val Gly Tyr Gly Ala Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Ile Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Arg Asn Gln Leu Gln Ala Ala Val Asn Ala Leu Lys Ser Asn Gly 
                85                  90                  95      


Ile Gln Val Tyr Gly Asp Val Val Met Asn His Lys Gly Gly Ala Asp 
            100                 105                 110         


Ala Thr Glu Asp Val Thr Ala Val Glu Val Asp Pro Ala Asp Arg Asn 
        115                 120                 125             


Arg Val Ile Ser Gly Glu His Leu Ile Lys Ala Trp Thr His Phe His 
    130                 135                 140                 


Phe Pro Gly Arg Gly Ser Thr Tyr Ser Asp Phe Lys Trp His Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Glu Ser Arg Lys Leu Asn Arg Ile 
                165                 170                 175     


Tyr Lys Phe Gln Gly Lys Ala Trp Asp Trp Glu Val Ser Asn Glu Phe 
            180                 185                 190         


Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Ile Asp Met Asp His Pro 
        195                 200                 205             


Glu Val Val Asn Glu Leu Arg Asn Trp Gly Val Trp Tyr Thr Asn Thr 
    210                 215                 220                 


Leu Gly Leu Asp Gly Phe Arg Ile Asp Ala Val Lys His Ile Lys Tyr 
225                 230                 235                 240 


Ser Phe Thr Arg Asp Trp Ile Asn His Val Arg Ser Ala Thr Gly Lys 
                245                 250                 255     


Asn Met Phe Ala Val Ala Glu Phe Trp Lys Asn Asp Leu Gly Ala Ile 
            260                 265                 270         


Glu Asn Tyr Leu Asn Lys Thr Asn Trp Asn His Ser Val Phe Asp Val 
        275                 280                 285             


Pro Leu His Tyr Asn Leu Tyr Asn Ala Ser Lys Ser Gly Gly Asn Tyr 
    290                 295                 300                 


Asp Met Arg Gln Ile Phe Asn Gly Thr Val Val Gln Arg His Pro Met 
305                 310                 315                 320 


His Ala Val Thr Phe Val Asp Asn His Asp Ser Gln Pro Glu Glu Ala 
                325                 330                 335     


Leu Glu Ser Phe Val Glu Glu Trp Phe Lys Pro Leu Ala Tyr Ala Leu 
            340                 345                 350         


Thr Leu Thr Arg Glu Gln Gly Tyr Pro Ser Val Phe Tyr Gly Asp Tyr 
        355                 360                 365             


Tyr Gly Ile Pro Thr His Gly Val Pro Ala Met Lys Ser Lys Ile Asp 
    370                 375                 380                 


Pro Ile Leu Glu Ala Arg Gln Lys Tyr Ala Tyr Gly Arg Gln Asn Asp 
385                 390                 395                 400 


Tyr Leu Asp His His Asn Ile Ile Gly Trp Thr Arg Glu Gly Asn Thr 
                405                 410                 415     


Ala His Pro Asn Ser Gly Leu Ala Thr Ile Met Ser Asp Gly Ala Gly 
            420                 425                 430         


Gly Asn Lys Trp Met Phe Val Gly Arg Asn Lys Ala Gly Gln Val Trp 
        435                 440                 445             


Thr Asp Ile Thr Gly Asn Arg Ala Gly Thr Val Thr Ile Asn Ala Asp 
    450                 455                 460                 


Gly Trp Gly Asn Phe Ser Val Asn Gly Gly Ser Val Ser Ile Trp Val 
465                 470                 475                 480 


Asn Lys 
        


<210>  173
<211>  484
<212>  PRT
<213>  Artifical Sequence

<400>  173

His His Asn Gly Thr Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr 
1               5                   10                  15      


Leu Pro Asn Asp Gly Asn His Trp Asn Arg Leu Arg Ser Asp Ala Ser 
            20                  25                  30          


Asn Leu Lys Asp Lys Gly Ile Ser Ala Val Trp Ile Pro Pro Ala Trp 
        35                  40                  45              


Lys Gly Ala Ser Gln Asn Asp Val Gly Tyr Gly Ala Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Ile Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Arg Asn Gln Leu Gln Ala Ala Val Asn Ala Leu Lys Ser Asn Gly 
                85                  90                  95      


Ile Gln Val Tyr Gly Asp Val Val Met Asn His Lys Ala Gly Ala Asp 
            100                 105                 110         


Tyr Thr Glu Asn Val Thr Ala Val Glu Val Asn Pro Ser Asn Arg Asn 
        115                 120                 125             


Gln Glu Thr Ser Gly Glu Tyr Asn Ile Gln Ala Trp Thr Gly Phe Asn 
    130                 135                 140                 


Phe Pro Gly Arg Gly Thr Thr Tyr Ser Asn Phe Lys Trp Gln Trp Phe 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Gln Ser Arg Ser Leu Ser Arg Ile 
                165                 170                 175     


Phe Lys Phe Arg Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Ser Ser 
            180                 185                 190         


Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Ile Asp Met Asp 
        195                 200                 205             


His Pro Glu Val Val Asn Glu Leu Arg Asn Trp Gly Val Trp Tyr Thr 
    210                 215                 220                 


Asn Thr Leu Gly Leu Asp Gly Phe Arg Ile Asp Ala Val Lys His Ile 
225                 230                 235                 240 


Lys Tyr Ser Phe Thr Arg Asp Trp Ile Asn His Val Arg Ser Ala Thr 
                245                 250                 255     


Gly Lys Asn Met Phe Ala Val Ala Glu Phe Trp Lys Asn Asp Leu Gly 
            260                 265                 270         


Ala Ile Glu Asn Tyr Leu Asn Lys Thr Asn Trp Asn His Ser Val Phe 
        275                 280                 285             


Asp Val Pro Leu His Tyr Asn Leu Tyr Asn Ala Ser Lys Ser Gly Gly 
    290                 295                 300                 


Asn Tyr Asp Met Arg Gln Ile Phe Asn Gly Thr Val Val Gln Arg His 
305                 310                 315                 320 


Pro Met His Ala Val Thr Phe Val Asp Asn His Asp Ser Gln Pro Glu 
                325                 330                 335     


Glu Ala Leu Glu Ser Phe Val Glu Glu Trp Phe Lys Pro Leu Ala Tyr 
            340                 345                 350         


Ala Leu Thr Leu Thr Arg Glu Gln Gly Tyr Pro Ser Val Phe Tyr Gly 
        355                 360                 365             


Asp Tyr Tyr Gly Ile Pro Thr His Gly Val Pro Ala Met Lys Ser Lys 
    370                 375                 380                 


Ile Asp Pro Ile Leu Glu Ala Arg Gln Lys Tyr Ala Tyr Gly Arg Gln 
385                 390                 395                 400 


Asn Asp Tyr Leu Asp His His Asn Ile Ile Gly Trp Thr Arg Glu Gly 
                405                 410                 415     


Asn Thr Ala His Pro Asn Ser Gly Leu Ala Thr Ile Met Ser Asp Gly 
            420                 425                 430         


Ala Gly Gly Asn Lys Trp Met Phe Val Gly Arg Asn Lys Ala Gly Gln 
        435                 440                 445             


Val Trp Thr Asp Ile Thr Gly Asn Arg Ala Gly Thr Val Thr Ile Asn 
    450                 455                 460                 


Ala Asp Gly Trp Gly Asn Phe Ser Val Asn Gly Gly Ser Val Ser Ile 
465                 470                 475                 480 


Trp Val Asn Lys 
                


<210>  174
<211>  484
<212>  PRT
<213>  Artifical Sequence

<400>  174

His His Asn Gly Thr Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr 
1               5                   10                  15      


Leu Pro Asn Asp Gly Asn His Trp Asn Arg Leu Arg Ser Asp Ala Ser 
            20                  25                  30          


Asn Leu Lys Asp Lys Gly Ile Ser Ala Val Trp Ile Pro Pro Ala Trp 
        35                  40                  45              


Lys Gly Ala Ser Gln Asn Asp Val Gly Tyr Gly Ala Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Ile Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Arg Asn Gln Leu Gln Ala Ala Val Asn Ala Leu Lys Ser Asn Gly 
                85                  90                  95      


Ile Gln Val Tyr Gly Asp Val Val Met Asp His Lys Gly Gly Ala Asp 
            100                 105                 110         


Gly Thr Glu Trp Val Asp Ala Val Glu Val Asn Pro Ser Asp Arg Asn 
        115                 120                 125             


Gln Glu Ile Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Val Asp Trp Asp Glu Ser Arg Lys Leu Ser Arg Ile 
                165                 170                 175     


Tyr Lys Phe Arg Gly Ile Gly Lys Ala Trp Asp Trp Glu Val Asp Thr 
            180                 185                 190         


Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Leu Asp Met Asp 
        195                 200                 205             


His Pro Glu Val Val Asn Glu Leu Arg Asn Trp Gly Val Trp Tyr Thr 
    210                 215                 220                 


Asn Thr Leu Gly Leu Asp Gly Phe Arg Ile Asp Ala Val Lys His Ile 
225                 230                 235                 240 


Lys Tyr Ser Phe Thr Arg Asp Trp Ile Asn His Val Arg Ser Ala Thr 
                245                 250                 255     


Gly Lys Asn Met Phe Ala Val Ala Glu Phe Trp Lys Asn Asp Leu Gly 
            260                 265                 270         


Ala Ile Glu Asn Tyr Leu Asn Lys Thr Asn Trp Asn His Ser Val Phe 
        275                 280                 285             


Asp Val Pro Leu His Tyr Asn Leu Tyr Asn Ala Ser Lys Ser Gly Gly 
    290                 295                 300                 


Asn Tyr Asp Met Arg Gln Ile Phe Asn Gly Thr Val Val Gln Arg His 
305                 310                 315                 320 


Pro Met His Ala Val Thr Phe Val Asp Asn His Asp Ser Gln Pro Glu 
                325                 330                 335     


Glu Ala Leu Glu Ser Phe Val Glu Glu Trp Phe Lys Pro Leu Ala Tyr 
            340                 345                 350         


Ala Leu Thr Leu Thr Arg Glu Gln Gly Tyr Pro Ser Val Phe Tyr Gly 
        355                 360                 365             


Asp Tyr Tyr Gly Ile Pro Thr His Gly Val Pro Ala Met Lys Ser Lys 
    370                 375                 380                 


Ile Asp Pro Ile Leu Glu Ala Arg Gln Lys Tyr Ala Tyr Gly Arg Gln 
385                 390                 395                 400 


Asn Asp Tyr Leu Asp His His Asn Ile Ile Gly Trp Thr Arg Glu Gly 
                405                 410                 415     


Asn Thr Ala His Pro Asn Ser Gly Leu Ala Thr Ile Met Ser Asp Gly 
            420                 425                 430         


Ala Gly Gly Asn Lys Trp Met Phe Val Gly Arg Asn Lys Ala Gly Gln 
        435                 440                 445             


Val Trp Thr Asp Ile Thr Gly Asn Arg Ala Gly Thr Val Thr Ile Asn 
    450                 455                 460                 


Ala Asp Gly Trp Gly Asn Phe Ser Val Asn Gly Gly Ser Val Ser Ile 
465                 470                 475                 480 


Trp Val Asn Lys 
                


<210>  175
<211>  484
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  175

His His Asn Gly Thr Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr 
1               5                   10                  15      


Leu Pro Asn Asp Gly Asn His Trp Asn Arg Leu Arg Ser Asp Ala Ser 
            20                  25                  30          


Asn Leu Lys Asp Lys Gly Ile Ser Ala Val Trp Ile Pro Pro Ala Trp 
        35                  40                  45              


Lys Gly Ala Ser Gln Asn Asp Val Gly Tyr Gly Ala Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Ile Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Arg Asn Gln Leu Gln Ala Ala Val Asn Ala Leu Lys Ser Asn Gly 
                85                  90                  95      


Ile Gln Val Tyr Gly Asp Val Val Met Asn His Lys Ala Gly Ala Asp 
            100                 105                 110         


Gly Thr Glu Leu Val Asp Ala Val Glu Val Asn Pro Ser Asp Arg Asn 
        115                 120                 125             


Gln Glu Ile Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Glu Ser Arg Lys Leu Asn Arg Ile 
                165                 170                 175     


Tyr Lys Phe Arg Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Asp Thr 
            180                 185                 190         


Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Leu Asp Met Asp 
        195                 200                 205             


His Pro Glu Val Val Asn Glu Leu Arg Asn Trp Gly Val Trp Tyr Thr 
    210                 215                 220                 


Asn Thr Leu Gly Leu Asp Gly Phe Arg Ile Asp Ala Val Lys His Ile 
225                 230                 235                 240 


Lys Tyr Ser Phe Thr Arg Asp Trp Ile Asn His Val Arg Ser Ala Thr 
                245                 250                 255     


Gly Lys Asn Met Phe Ala Val Ala Glu Phe Trp Lys Asn Asp Leu Gly 
            260                 265                 270         


Ala Ile Glu Asn Tyr Leu Asn Lys Thr Asn Trp Asn His Ser Val Phe 
        275                 280                 285             


Asp Val Pro Leu His Tyr Asn Leu Tyr Asn Ala Ser Lys Ser Gly Gly 
    290                 295                 300                 


Asn Tyr Asp Met Arg Gln Ile Phe Asn Gly Thr Val Val Gln Arg His 
305                 310                 315                 320 


Pro Met His Ala Val Thr Phe Val Asp Asn His Asp Ser Gln Pro Glu 
                325                 330                 335     


Glu Ala Leu Glu Ser Phe Val Glu Glu Trp Phe Lys Pro Leu Ala Tyr 
            340                 345                 350         


Ala Leu Thr Leu Thr Arg Glu Gln Gly Tyr Pro Ser Val Phe Tyr Gly 
        355                 360                 365             


Asp Tyr Tyr Gly Ile Pro Thr His Gly Val Pro Ala Met Lys Ser Lys 
    370                 375                 380                 


Ile Asp Pro Ile Leu Glu Ala Arg Gln Lys Tyr Ala Tyr Gly Arg Gln 
385                 390                 395                 400 


Asn Asp Tyr Leu Asp His His Asn Ile Ile Gly Trp Thr Arg Glu Gly 
                405                 410                 415     


Asn Thr Ala His Pro Asn Ser Gly Leu Ala Thr Ile Met Ser Asp Gly 
            420                 425                 430         


Ala Gly Gly Asn Lys Trp Met Phe Val Gly Arg Asn Lys Ala Gly Gln 
        435                 440                 445             


Val Trp Thr Asp Ile Thr Gly Asn Arg Ala Gly Thr Val Thr Ile Asn 
    450                 455                 460                 


Ala Asp Gly Trp Gly Asn Phe Ser Val Asn Gly Gly Ser Val Ser Ile 
465                 470                 475                 480 


Trp Val Asn Lys 
                


<210>  176
<211>  484
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  176

His His Asn Gly Thr Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr 
1               5                   10                  15      


Leu Pro Asn Asp Gly Asn His Trp Asn Arg Leu Arg Ser Asp Ala Ser 
            20                  25                  30          


Asn Leu Lys Asp Lys Gly Ile Ser Ala Val Trp Ile Pro Pro Ala Trp 
        35                  40                  45              


Lys Gly Ala Ser Gln Asn Asp Val Gly Tyr Gly Ala Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Ile Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Arg Asn Gln Leu Gln Ala Ala Val Asn Ala Leu Lys Ser Asn Gly 
                85                  90                  95      


Ile Gln Val Tyr Gly Asp Val Val Met Asn His Lys Ala Gly Ala Asp 
            100                 105                 110         


Gly Thr Glu Phe Val Asp Ala Val Glu Val Asn Pro Ser Asn Arg Asn 
        115                 120                 125             


Gln Glu Thr Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Glu Ser Arg Lys Leu Asn Arg Val 
                165                 170                 175     


Tyr Lys Phe Arg Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Asp Thr 
            180                 185                 190         


Glu Asn Gly Asn Tyr Asp Tyr Leu Met Phe Ala Asp Leu Asp Met Asp 
        195                 200                 205             


His Pro Glu Val Val Asn Glu Leu Arg Asn Trp Gly Val Trp Tyr Thr 
    210                 215                 220                 


Asn Thr Leu Gly Leu Asp Gly Phe Arg Ile Asp Ala Val Lys His Ile 
225                 230                 235                 240 


Lys Tyr Ser Phe Thr Arg Asp Trp Ile Asn His Val Arg Ser Ala Thr 
                245                 250                 255     


Gly Lys Asn Met Phe Ala Val Ala Glu Phe Trp Lys Asn Asp Leu Gly 
            260                 265                 270         


Ala Ile Glu Asn Tyr Leu Asn Lys Thr Asn Trp Asn His Ser Val Phe 
        275                 280                 285             


Asp Val Pro Leu His Tyr Asn Leu Tyr Asn Ala Ser Lys Ser Gly Gly 
    290                 295                 300                 


Asn Tyr Asp Met Arg Gln Ile Phe Asn Gly Thr Val Val Gln Arg His 
305                 310                 315                 320 


Pro Met His Ala Val Thr Phe Val Asp Asn His Asp Ser Gln Pro Glu 
                325                 330                 335     


Glu Ala Leu Glu Ser Phe Val Glu Glu Trp Phe Lys Pro Leu Ala Tyr 
            340                 345                 350         


Ala Leu Thr Leu Thr Arg Glu Gln Gly Tyr Pro Ser Val Phe Tyr Gly 
        355                 360                 365             


Asp Tyr Tyr Gly Ile Pro Thr His Gly Val Pro Ala Met Lys Ser Lys 
    370                 375                 380                 


Ile Asp Pro Ile Leu Glu Ala Arg Gln Lys Tyr Ala Tyr Gly Arg Gln 
385                 390                 395                 400 


Asn Asp Tyr Leu Asp His His Asn Ile Ile Gly Trp Thr Arg Glu Gly 
                405                 410                 415     


Asn Thr Ala His Pro Asn Ser Gly Leu Ala Thr Ile Met Ser Asp Gly 
            420                 425                 430         


Ala Gly Gly Asn Lys Trp Met Phe Val Gly Arg Asn Lys Ala Gly Gln 
        435                 440                 445             


Val Trp Thr Asp Ile Thr Gly Asn Arg Ala Gly Thr Val Thr Ile Asn 
    450                 455                 460                 


Ala Asp Gly Trp Gly Asn Phe Ser Val Asn Gly Gly Ser Val Ser Ile 
465                 470                 475                 480 


Trp Val Asn Lys 
                


<210>  177
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  177

His His Asn Gly Thr Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr 
1               5                   10                  15      


Leu Pro Asn Asp Gly Asn His Trp Asn Arg Leu Arg Ser Asp Ala Ser 
            20                  25                  30          


Asn Leu Lys Asp Lys Gly Ile Ser Ala Val Trp Ile Pro Pro Ala Trp 
        35                  40                  45              


Lys Gly Ala Ser Gln Asn Asp Val Gly Tyr Gly Ala Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Ile Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Arg Asn Gln Leu Gln Ala Ala Val Asn Ala Leu Lys Ser Asn Gly 
                85                  90                  95      


Ile Gln Val Tyr Gly Asp Val Val Met Asn His Lys Ala Gly Ala Asp 
            100                 105                 110         


Gly Thr Glu Phe Val Asp Ala Val Glu Val Asp Pro Ser Asn Arg Asn 
        115                 120                 125             


Gln Glu Thr Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Glu Ser Arg Lys Leu Asn Arg Ile 
                165                 170                 175     


Tyr Lys Phe Ser Thr Gly Lys Ala Trp Asp Trp Glu Val Asp Thr Glu 
            180                 185                 190         


Asn Gly Asn Tyr Asp Tyr Leu Met Phe Ala Asp Leu Asp Met Asp His 
        195                 200                 205             


Pro Glu Val Val Asn Glu Leu Arg Asn Trp Gly Val Trp Tyr Thr Asn 
    210                 215                 220                 


Thr Leu Gly Leu Asp Gly Phe Arg Ile Asp Ala Val Lys His Ile Lys 
225                 230                 235                 240 


Tyr Ser Phe Thr Arg Asp Trp Ile Asn His Val Arg Ser Ala Thr Gly 
                245                 250                 255     


Lys Asn Met Phe Ala Val Ala Glu Phe Trp Lys Asn Asp Leu Gly Ala 
            260                 265                 270         


Ile Glu Asn Tyr Leu Asn Lys Thr Asn Trp Asn His Ser Val Phe Asp 
        275                 280                 285             


Val Pro Leu His Tyr Asn Leu Tyr Asn Ala Ser Lys Ser Gly Gly Asn 
    290                 295                 300                 


Tyr Asp Met Arg Gln Ile Phe Asn Gly Thr Val Val Gln Arg His Pro 
305                 310                 315                 320 


Met His Ala Val Thr Phe Val Asp Asn His Asp Ser Gln Pro Glu Glu 
                325                 330                 335     


Ala Leu Glu Ser Phe Val Glu Glu Trp Phe Lys Pro Leu Ala Tyr Ala 
            340                 345                 350         


Leu Thr Leu Thr Arg Glu Gln Gly Tyr Pro Ser Val Phe Tyr Gly Asp 
        355                 360                 365             


Tyr Tyr Gly Ile Pro Thr His Gly Val Pro Ala Met Lys Ser Lys Ile 
    370                 375                 380                 


Asp Pro Ile Leu Glu Ala Arg Gln Lys Tyr Ala Tyr Gly Arg Gln Asn 
385                 390                 395                 400 


Asp Tyr Leu Asp His His Asn Ile Ile Gly Trp Thr Arg Glu Gly Asn 
                405                 410                 415     


Thr Ala His Pro Asn Ser Gly Leu Ala Thr Ile Met Ser Asp Gly Ala 
            420                 425                 430         


Gly Gly Asn Lys Trp Met Phe Val Gly Arg Asn Lys Ala Gly Gln Val 
        435                 440                 445             


Trp Thr Asp Ile Thr Gly Asn Arg Ala Gly Thr Val Thr Ile Asn Ala 
    450                 455                 460                 


Asp Gly Trp Gly Asn Phe Ser Val Asn Gly Gly Ser Val Ser Ile Trp 
465                 470                 475                 480 


Val Asn Lys 
            


<210>  178
<211>  484
<212>  PRT
<213>  Artifiical Sequence

<400>  178

His His Asn Gly Thr Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr 
1               5                   10                  15      


Leu Pro Asn Asp Gly Asn His Trp Asn Arg Leu Arg Ser Asp Ala Ser 
            20                  25                  30          


Asn Leu Lys Asp Lys Gly Ile Ser Ala Val Trp Ile Pro Pro Ala Trp 
        35                  40                  45              


Lys Gly Ala Ser Gln Asn Asp Val Gly Tyr Gly Ala Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Ile Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Arg Asn Gln Leu Gln Ala Ala Val Asn Ala Leu Lys Ser Asn Gly 
                85                  90                  95      


Ile Gln Val Tyr Gly Asp Val Val Met Asn His Lys Ala Gly Ala Asp 
            100                 105                 110         


Gly Thr Glu Phe Val Asp Ala Val Glu Val Asn Pro Ser Asn Arg Asn 
        115                 120                 125             


Gln Glu Thr Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Glu Ser Arg Lys Leu Asn Arg Ile 
                165                 170                 175     


Tyr Lys Phe Arg Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Asp Thr 
            180                 185                 190         


Glu Asn Gly Asn Tyr Asp Tyr Leu Met Phe Ala Asp Leu Asp Met Asp 
        195                 200                 205             


His Pro Glu Val Val Asn Glu Leu Arg Asn Trp Gly Val Trp Tyr Thr 
    210                 215                 220                 


Asn Thr Leu Gly Leu Asp Gly Phe Arg Ile Asp Ala Val Lys His Ile 
225                 230                 235                 240 


Lys Tyr Ser Phe Thr Arg Asp Trp Ile Asn His Val Arg Ser Ala Thr 
                245                 250                 255     


Gly Lys Asn Met Phe Ala Val Ala Glu Phe Trp Lys Asn Asp Leu Gly 
            260                 265                 270         


Ala Ile Glu Asn Tyr Leu Asn Lys Thr Asn Trp Asn His Ser Val Phe 
        275                 280                 285             


Asp Val Pro Leu His Tyr Asn Leu Tyr Asn Ala Ser Lys Ser Gly Gly 
    290                 295                 300                 


Asn Tyr Asp Met Arg Gln Ile Phe Asn Gly Thr Val Val Gln Arg His 
305                 310                 315                 320 


Pro Met His Ala Val Thr Phe Val Asp Asn His Asp Ser Gln Pro Glu 
                325                 330                 335     


Glu Ala Leu Glu Ser Phe Val Glu Glu Trp Phe Lys Pro Leu Ala Tyr 
            340                 345                 350         


Ala Leu Thr Leu Thr Arg Glu Gln Gly Tyr Pro Ser Val Phe Tyr Gly 
        355                 360                 365             


Asp Tyr Tyr Gly Ile Pro Thr His Gly Val Pro Ala Met Lys Ser Lys 
    370                 375                 380                 


Ile Asp Pro Ile Leu Glu Ala Arg Gln Lys Tyr Ala Tyr Gly Arg Gln 
385                 390                 395                 400 


Asn Asp Tyr Leu Asp His His Asn Ile Ile Gly Trp Thr Arg Glu Gly 
                405                 410                 415     


Asn Thr Ala His Pro Asn Ser Gly Leu Ala Thr Ile Met Ser Asp Gly 
            420                 425                 430         


Ala Gly Gly Asn Lys Trp Met Phe Val Gly Arg Asn Lys Ala Gly Gln 
        435                 440                 445             


Val Trp Thr Asp Ile Thr Gly Asn Arg Ala Gly Thr Val Thr Ile Asn 
    450                 455                 460                 


Ala Asp Gly Trp Gly Asn Phe Ser Val Asn Gly Gly Ser Val Ser Ile 
465                 470                 475                 480 


Trp Val Asn Lys 
                


<210>  179
<211>  484
<212>  PRT
<213>  Artifical Sequence

<400>  179

His His Asn Gly Thr Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr 
1               5                   10                  15      


Leu Pro Asn Asp Gly Asn His Trp Asn Arg Leu Arg Ser Asp Ala Ser 
            20                  25                  30          


Asn Leu Lys Asp Lys Gly Ile Ser Ala Val Trp Ile Pro Pro Ala Trp 
        35                  40                  45              


Lys Gly Ala Ser Gln Asn Asp Val Gly Tyr Gly Ala Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Ile Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Arg Asn Gln Leu Gln Ala Ala Val Asn Ala Leu Lys Ser Asn Gly 
                85                  90                  95      


Ile Gln Val Tyr Gly Asp Val Val Met Asn His Lys Ala Gly Ala Asp 
            100                 105                 110         


Ala Thr Glu Trp Val Asp Ala Val Glu Val Asn Pro Ser Asn Arg Asn 
        115                 120                 125             


Gln Glu Val Ser Gly Thr Tyr Lys Ile Gln Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Gln Ser Arg Gln Leu Asn Arg Ile 
                165                 170                 175     


Tyr Lys Phe Arg Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Asp Thr 
            180                 185                 190         


Glu Asn Gly Asn Tyr Asp Tyr Leu Met Phe Ala Asp Leu Asp Met Asp 
        195                 200                 205             


His Pro Glu Val Val Asn Glu Leu Arg Asn Trp Gly Val Trp Tyr Thr 
    210                 215                 220                 


Asn Thr Leu Gly Leu Asp Gly Phe Arg Ile Asp Ala Val Lys His Ile 
225                 230                 235                 240 


Lys Tyr Ser Phe Thr Arg Asp Trp Ile Asn His Val Arg Ser Ala Thr 
                245                 250                 255     


Gly Lys Asn Met Phe Ala Val Ala Glu Phe Trp Lys Asn Asp Leu Gly 
            260                 265                 270         


Ala Ile Glu Asn Tyr Leu Asn Lys Thr Asn Trp Asn His Ser Val Phe 
        275                 280                 285             


Asp Val Pro Leu His Tyr Asn Leu Tyr Asn Ala Ser Lys Ser Gly Gly 
    290                 295                 300                 


Asn Tyr Asp Met Arg Gln Ile Phe Asn Gly Thr Val Val Gln Arg His 
305                 310                 315                 320 


Pro Met His Ala Val Thr Phe Val Asp Asn His Asp Ser Gln Pro Glu 
                325                 330                 335     


Glu Ala Leu Glu Ser Phe Val Glu Glu Trp Phe Lys Pro Leu Ala Tyr 
            340                 345                 350         


Ala Leu Thr Leu Thr Arg Glu Gln Gly Tyr Pro Ser Val Phe Tyr Gly 
        355                 360                 365             


Asp Tyr Tyr Gly Ile Pro Thr His Gly Val Pro Ala Met Lys Ser Lys 
    370                 375                 380                 


Ile Asp Pro Ile Leu Glu Ala Arg Gln Lys Tyr Ala Tyr Gly Arg Gln 
385                 390                 395                 400 


Asn Asp Tyr Leu Asp His His Asn Ile Ile Gly Trp Thr Arg Glu Gly 
                405                 410                 415     


Asn Thr Ala His Pro Asn Ser Gly Leu Ala Thr Ile Met Ser Asp Gly 
            420                 425                 430         


Ala Gly Gly Asn Lys Trp Met Phe Val Gly Arg Asn Lys Ala Gly Gln 
        435                 440                 445             


Val Trp Thr Asp Ile Thr Gly Asn Arg Ala Gly Thr Val Thr Ile Asn 
    450                 455                 460                 


Ala Asp Gly Trp Gly Asn Phe Ser Val Asn Gly Gly Ser Val Ser Ile 
465                 470                 475                 480 


Trp Val Asn Lys 
                


<210>  180
<211>  484
<212>  PRT
<213>  Artifical Sequence

<400>  180

His His Asn Gly Thr Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr 
1               5                   10                  15      


Leu Pro Asn Asp Gly Asn His Trp Asn Arg Leu Arg Ser Asp Ala Ser 
            20                  25                  30          


Asn Leu Lys Asp Lys Gly Ile Ser Ala Val Trp Ile Pro Pro Ala Trp 
        35                  40                  45              


Lys Gly Ala Ser Gln Asn Asp Val Gly Tyr Gly Ala Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Ile Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Arg Asn Gln Leu Gln Ala Ala Val Asn Ala Leu Lys Ser Asn Gly 
                85                  90                  95      


Ile Gln Val Tyr Gly Asp Val Val Met Asn His Lys Ala Gly Ala Asp 
            100                 105                 110         


Ser Thr Glu Trp Val Asp Ala Val Glu Val Asn Pro Ser Asn Arg Asn 
        115                 120                 125             


Gln Glu Thr Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Glu Ser Arg Lys Leu Asn Arg Ile 
                165                 170                 175     


Tyr Lys Phe Arg Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Asp Thr 
            180                 185                 190         


Glu Asn Gly Asn Tyr Asp Tyr Leu Met Phe Ala Asp Leu Asp Met Asp 
        195                 200                 205             


His Pro Glu Val Val Asn Glu Leu Arg Asn Trp Gly Val Trp Tyr Thr 
    210                 215                 220                 


Asn Thr Leu Gly Leu Asp Gly Phe Arg Ile Asp Ala Val Lys His Ile 
225                 230                 235                 240 


Lys Tyr Ser Phe Thr Arg Asp Trp Ile Asn His Val Arg Ser Ala Thr 
                245                 250                 255     


Gly Lys Asn Met Phe Ala Val Ala Glu Phe Trp Lys Asn Asp Leu Gly 
            260                 265                 270         


Ala Ile Glu Asn Tyr Leu Asn Lys Thr Asn Trp Asn His Ser Val Phe 
        275                 280                 285             


Asp Val Pro Leu His Tyr Asn Leu Tyr Asn Ala Ser Lys Ser Gly Gly 
    290                 295                 300                 


Asn Tyr Asp Met Arg Gln Ile Phe Asn Gly Thr Val Val Gln Arg His 
305                 310                 315                 320 


Pro Met His Ala Val Thr Phe Val Asp Asn His Asp Ser Gln Pro Glu 
                325                 330                 335     


Glu Ala Leu Glu Ser Phe Val Glu Glu Trp Phe Lys Pro Leu Ala Tyr 
            340                 345                 350         


Ala Leu Thr Leu Thr Arg Glu Gln Gly Tyr Pro Ser Val Phe Tyr Gly 
        355                 360                 365             


Asp Tyr Tyr Gly Ile Pro Thr His Gly Val Pro Ala Met Lys Ser Lys 
    370                 375                 380                 


Ile Asp Pro Ile Leu Glu Ala Arg Gln Lys Tyr Ala Tyr Gly Arg Gln 
385                 390                 395                 400 


Asn Asp Tyr Leu Asp His His Asn Ile Ile Gly Trp Thr Arg Glu Gly 
                405                 410                 415     


Asn Thr Ala His Pro Asn Ser Gly Leu Ala Thr Ile Met Ser Asp Gly 
            420                 425                 430         


Ala Gly Gly Asn Lys Trp Met Phe Val Gly Arg Asn Lys Ala Gly Gln 
        435                 440                 445             


Val Trp Thr Asp Ile Thr Gly Asn Arg Ala Gly Thr Val Thr Ile Asn 
    450                 455                 460                 


Ala Asp Gly Trp Gly Asn Phe Ser Val Asn Gly Gly Ser Val Ser Ile 
465                 470                 475                 480 


Trp Val Asn Lys 
                


<210>  181
<211>  485
<212>  PRT
<213>  Artifical Sequence

<400>  181

His His Asn Gly Thr Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr 
1               5                   10                  15      


Leu Pro Asn Asp Gly Asn His Trp Asn Arg Leu Arg Ser Asp Ala Ser 
            20                  25                  30          


Asn Leu Lys Asp Lys Gly Ile Ser Ala Val Trp Ile Pro Pro Ala Trp 
        35                  40                  45              


Lys Gly Ala Ser Gln Asn Asp Val Gly Tyr Gly Ala Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Ile Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Arg Asn Gln Leu Gln Ala Ala Val Asn Ala Leu Lys Ser Asn Gly 
                85                  90                  95      


Ile Gln Val Tyr Gly Asp Val Val Met Asn His Lys Gly Gly Ala Asp 
            100                 105                 110         


Phe Thr Glu Arg Val Gln Ala Val Glu Val Asn Pro Gln Asn Arg Asn 
        115                 120                 125             


Gln Glu Val Ser Gly Thr Tyr Gln Ile Glu Ala Trp Thr Gly Phe Asn 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Gln His Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Gln Ser Arg Gln Leu Ala Asn Arg 
                165                 170                 175     


Ile Tyr Lys Phe Arg Gly Asp Gly Lys Ala Trp Asp Trp Glu Val Asp 
            180                 185                 190         


Thr Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Val Asp Met 
        195                 200                 205             


Asp His Pro Glu Val Val Asn Glu Leu Arg Asn Trp Gly Val Trp Tyr 
    210                 215                 220                 


Thr Asn Thr Leu Gly Leu Asp Gly Phe Arg Ile Asp Ala Val Lys His 
225                 230                 235                 240 


Ile Lys Tyr Ser Phe Thr Arg Asp Trp Ile Asn His Val Arg Ser Ala 
                245                 250                 255     


Thr Gly Lys Asn Met Phe Ala Val Ala Glu Phe Trp Lys Asn Asp Leu 
            260                 265                 270         


Gly Ala Ile Glu Asn Tyr Leu Asn Lys Thr Asn Trp Asn His Ser Val 
        275                 280                 285             


Phe Asp Val Pro Leu His Tyr Asn Leu Tyr Asn Ala Ser Lys Ser Gly 
    290                 295                 300                 


Gly Asn Tyr Asp Met Arg Gln Ile Phe Asn Gly Thr Val Val Gln Arg 
305                 310                 315                 320 


His Pro Met His Ala Val Thr Phe Val Asp Asn His Asp Ser Gln Pro 
                325                 330                 335     


Glu Glu Ala Leu Glu Ser Phe Val Glu Glu Trp Phe Lys Pro Leu Ala 
            340                 345                 350         


Tyr Ala Leu Thr Leu Thr Arg Glu Gln Gly Tyr Pro Ser Val Phe Tyr 
        355                 360                 365             


Gly Asp Tyr Tyr Gly Ile Pro Thr His Gly Val Pro Ala Met Lys Ser 
    370                 375                 380                 


Lys Ile Asp Pro Ile Leu Glu Ala Arg Gln Lys Tyr Ala Tyr Gly Arg 
385                 390                 395                 400 


Gln Asn Asp Tyr Leu Asp His His Asn Ile Ile Gly Trp Thr Arg Glu 
                405                 410                 415     


Gly Asn Thr Ala His Pro Asn Ser Gly Leu Ala Thr Ile Met Ser Asp 
            420                 425                 430         


Gly Ala Gly Gly Asn Lys Trp Met Phe Val Gly Arg Asn Lys Ala Gly 
        435                 440                 445             


Gln Val Trp Thr Asp Ile Thr Gly Asn Arg Ala Gly Thr Val Thr Ile 
    450                 455                 460                 


Asn Ala Asp Gly Trp Gly Asn Phe Ser Val Asn Gly Gly Ser Val Ser 
465                 470                 475                 480 


Ile Trp Val Asn Lys 
                485 


<210>  182
<211>  485
<212>  PRT
<213>  Artifical Sequence

<400>  182

His His Asn Gly Thr Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr 
1               5                   10                  15      


Leu Pro Asn Asp Gly Asn His Trp Asn Arg Leu Arg Ser Asp Ala Ser 
            20                  25                  30          


Asn Leu Lys Asp Lys Gly Ile Ser Ala Val Trp Ile Pro Pro Ala Trp 
        35                  40                  45              


Lys Gly Ala Ser Gln Asn Asp Val Gly Tyr Gly Ala Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Ile Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Arg Asn Gln Leu Gln Ala Ala Val Asn Ala Leu Lys Ser Asn Gly 
                85                  90                  95      


Ile Gln Val Tyr Gly Asp Val Val Met Asn His Lys Gly Gly Ala Asp 
            100                 105                 110         


Ala Thr Glu Asn Val Leu Ala Val Glu Val Asn Pro Asn Asn Arg Asn 
        115                 120                 125             


Gln Glu Ile Ser Gly Asp Tyr Thr Ile Glu Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Asp Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Val Asp Trp Asp Gln Ser Arg Gln Phe Gln Asn Arg 
                165                 170                 175     


Ile Tyr Lys Phe Arg Gly Asp Gly Lys Ala Trp Asp Trp Glu Val Asp 
            180                 185                 190         


Ser Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Val Asp Met 
        195                 200                 205             


Asp His Pro Glu Val Val Asn Glu Leu Arg Asn Trp Gly Val Trp Tyr 
    210                 215                 220                 


Thr Asn Thr Leu Gly Leu Asp Gly Phe Arg Ile Asp Ala Val Lys His 
225                 230                 235                 240 


Ile Lys Tyr Ser Phe Thr Arg Asp Trp Ile Asn His Val Arg Ser Ala 
                245                 250                 255     


Thr Gly Lys Asn Met Phe Ala Val Ala Glu Phe Trp Lys Asn Asp Leu 
            260                 265                 270         


Gly Ala Ile Glu Asn Tyr Leu Asn Lys Thr Asn Trp Asn His Ser Val 
        275                 280                 285             


Phe Asp Val Pro Leu His Tyr Asn Leu Tyr Asn Ala Ser Lys Ser Gly 
    290                 295                 300                 


Gly Asn Tyr Asp Met Arg Gln Ile Phe Asn Gly Thr Val Val Gln Arg 
305                 310                 315                 320 


His Pro Met His Ala Val Thr Phe Val Asp Asn His Asp Ser Gln Pro 
                325                 330                 335     


Glu Glu Ala Leu Glu Ser Phe Val Glu Glu Trp Phe Lys Pro Leu Ala 
            340                 345                 350         


Tyr Ala Leu Thr Leu Thr Arg Glu Gln Gly Tyr Pro Ser Val Phe Tyr 
        355                 360                 365             


Gly Asp Tyr Tyr Gly Ile Pro Thr His Gly Val Pro Ala Met Lys Ser 
    370                 375                 380                 


Lys Ile Asp Pro Ile Leu Glu Ala Arg Gln Lys Tyr Ala Tyr Gly Arg 
385                 390                 395                 400 


Gln Asn Asp Tyr Leu Asp His His Asn Ile Ile Gly Trp Thr Arg Glu 
                405                 410                 415     


Gly Asn Thr Ala His Pro Asn Ser Gly Leu Ala Thr Ile Met Ser Asp 
            420                 425                 430         


Gly Ala Gly Gly Asn Lys Trp Met Phe Val Gly Arg Asn Lys Ala Gly 
        435                 440                 445             


Gln Val Trp Thr Asp Ile Thr Gly Asn Arg Ala Gly Thr Val Thr Ile 
    450                 455                 460                 


Asn Ala Asp Gly Trp Gly Asn Phe Ser Val Asn Gly Gly Ser Val Ser 
465                 470                 475                 480 


Ile Trp Val Asn Lys 
                485 


<210>  183
<211>  485
<212>  PRT
<213>  Artifical Sequence

<400>  183

His His Asn Gly Thr Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr 
1               5                   10                  15      


Leu Pro Asn Asp Gly Asn His Trp Asn Arg Leu Arg Ser Asp Ala Ser 
            20                  25                  30          


Asn Leu Lys Asp Lys Gly Ile Ser Ala Val Trp Ile Pro Pro Ala Trp 
        35                  40                  45              


Lys Gly Ala Ser Gln Asn Asp Val Gly Tyr Gly Ala Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Ile Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Arg Asn Gln Leu Gln Ala Ala Val Asn Ala Leu Lys Ser Asn Gly 
                85                  90                  95      


Ile Gln Val Tyr Gly Asp Val Val Met Asn His Lys Gly Gly Ala Asp 
            100                 105                 110         


Ala Thr Glu Met Val Arg Ala Val Glu Val Asn Pro Asn Asn Arg Asn 
        115                 120                 125             


Gln Glu Val Thr Gly Glu Tyr Thr Ile Glu Ala Trp Thr Arg Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr His Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Val Asp Trp Asp Gln Ser Arg Arg Leu Asn Asn Arg 
                165                 170                 175     


Ile Tyr Lys Phe Arg Gly His Gly Lys Ala Trp Asp Trp Glu Val Asp 
            180                 185                 190         


Thr Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Ile Asp Met 
        195                 200                 205             


Asp His Pro Glu Val Val Asn Glu Leu Arg Asn Trp Gly Val Trp Tyr 
    210                 215                 220                 


Thr Asn Thr Leu Gly Leu Asp Gly Phe Arg Ile Asp Ala Val Lys His 
225                 230                 235                 240 


Ile Lys Tyr Ser Phe Thr Arg Asp Trp Ile Asn His Val Arg Ser Ala 
                245                 250                 255     


Thr Gly Lys Asn Met Phe Ala Val Ala Glu Phe Trp Lys Asn Asp Leu 
            260                 265                 270         


Gly Ala Ile Glu Asn Tyr Leu Asn Lys Thr Asn Trp Asn His Ser Val 
        275                 280                 285             


Phe Asp Val Pro Leu His Tyr Asn Leu Tyr Asn Ala Ser Lys Ser Gly 
    290                 295                 300                 


Gly Asn Tyr Asp Met Arg Gln Ile Phe Asn Gly Thr Val Val Gln Arg 
305                 310                 315                 320 


His Pro Met His Ala Val Thr Phe Val Asp Asn His Asp Ser Gln Pro 
                325                 330                 335     


Glu Glu Ala Leu Glu Ser Phe Val Glu Glu Trp Phe Lys Pro Leu Ala 
            340                 345                 350         


Tyr Ala Leu Thr Leu Thr Arg Glu Gln Gly Tyr Pro Ser Val Phe Tyr 
        355                 360                 365             


Gly Asp Tyr Tyr Gly Ile Pro Thr His Gly Val Pro Ala Met Lys Ser 
    370                 375                 380                 


Lys Ile Asp Pro Ile Leu Glu Ala Arg Gln Lys Tyr Ala Tyr Gly Arg 
385                 390                 395                 400 


Gln Asn Asp Tyr Leu Asp His His Asn Ile Ile Gly Trp Thr Arg Glu 
                405                 410                 415     


Gly Asn Thr Ala His Pro Asn Ser Gly Leu Ala Thr Ile Met Ser Asp 
            420                 425                 430         


Gly Ala Gly Gly Asn Lys Trp Met Phe Val Gly Arg Asn Lys Ala Gly 
        435                 440                 445             


Gln Val Trp Thr Asp Ile Thr Gly Asn Arg Ala Gly Thr Val Thr Ile 
    450                 455                 460                 


Asn Ala Asp Gly Trp Gly Asn Phe Ser Val Asn Gly Gly Ser Val Ser 
465                 470                 475                 480 


Ile Trp Val Asn Lys 
                485 


<210>  184
<211>  485
<212>  PRT
<213>  Artifical Sequence

<400>  184

His His Asn Gly Thr Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr 
1               5                   10                  15      


Leu Pro Asn Asp Gly Asn His Trp Asn Arg Leu Asn Ser Asp Ala Ser 
            20                  25                  30          


Asn Leu Lys Ser Lys Gly Ile Thr Ala Val Trp Ile Pro Pro Ala Trp 
        35                  40                  45              


Lys Gly Ala Ser Gln Asn Asp Val Gly Tyr Gly Ala Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Arg Ser Gln Leu Gln Ala Ala Val Thr Ser Leu Lys Asn Asn Gly 
                85                  90                  95      


Ile Gln Val Tyr Gly Asp Val Val Met Asn His Arg Met Gly Ala Asp 
            100                 105                 110         


Ala Thr Glu Thr Ile Ser Ala Val Glu Val Asn Pro Ser Asn Arg Asn 
        115                 120                 125             


Gln Val Thr Ser Gly Ala Tyr Asn Ile Ser Ala Trp Thr Asp Phe Glu 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp His Ser Tyr 
145                 150                 155                 160 


Tyr Phe Asp Gly Val Asp Trp Asp Gln Ser Arg Gln Leu Ser Gly Lys 
                165                 170                 175     


Ile Tyr Gln Ile Gln Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Asp 
            180                 185                 190         


Ser Glu Asn Gly Asn Tyr Asp Tyr Leu Met Gly Ala Asp Ile Asp Met 
        195                 200                 205             


Asp His Pro Glu Val Val Asn Glu Leu Arg Asn Trp Gly Val Trp Tyr 
    210                 215                 220                 


Thr Asn Thr Leu Gly Leu Asp Gly Phe Arg Ile Asp Ala Val Lys His 
225                 230                 235                 240 


Ile Lys Tyr Ser Phe Thr Arg Asp Trp Ile Asn His Val Arg Ser Ala 
                245                 250                 255     


Thr Gly Lys Asn Met Phe Ala Val Ala Glu Phe Trp Lys Asn Asp Leu 
            260                 265                 270         


Gly Ala Ile Glu Asn Tyr Leu Gln Lys Thr Asn Trp Asn His Ser Val 
        275                 280                 285             


Phe Asp Val Pro Leu His Tyr Asn Leu Tyr Asn Ala Ser Lys Ser Gly 
    290                 295                 300                 


Gly Asn Tyr Asp Met Arg Asn Ile Phe Asn Gly Thr Val Val Gln Arg 
305                 310                 315                 320 


His Pro Ser His Ala Val Thr Phe Val Asp Asn His Asp Ser Gln Pro 
                325                 330                 335     


Glu Glu Ala Leu Glu Ser Phe Val Glu Glu Trp Phe Lys Pro Leu Ala 
            340                 345                 350         


Tyr Ala Leu Thr Leu Thr Arg Glu Gln Gly Tyr Pro Ser Val Phe Tyr 
        355                 360                 365             


Gly Asp Tyr Tyr Gly Ile Pro Thr His Gly Val Pro Ala Met Arg Ser 
    370                 375                 380                 


Lys Ile Asp Pro Ile Leu Glu Ala Arg Gln Lys Tyr Ala Tyr Gly Lys 
385                 390                 395                 400 


Gln Asn Asp Tyr Leu Asp His His Asn Ile Ile Gly Trp Thr Arg Glu 
                405                 410                 415     


Gly Asn Thr Ala His Pro Asn Ser Gly Leu Ala Thr Ile Met Ser Asp 
            420                 425                 430         


Gly Ala Gly Gly Ser Lys Trp Met Phe Val Gly Arg Asn Lys Ala Gly 
        435                 440                 445             


Gln Val Trp Ser Asp Ile Thr Gly Asn Arg Thr Gly Thr Val Thr Ile 
    450                 455                 460                 


Asn Ala Asp Gly Trp Gly Asn Phe Ser Val Asn Gly Gly Ser Val Ser 
465                 470                 475                 480 


Ile Trp Val Asn Lys 
                485 


<210>  185
<211>  484
<212>  PRT
<213>  Artifical Sequence

<400>  185

His His Asn Gly Thr Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr 
1               5                   10                  15      


Leu Pro Asn Asp Gly Asn His Trp Asn Arg Leu Asn Ser Asp Ala Ser 
            20                  25                  30          


Asn Leu Lys Ser Lys Gly Ile Thr Ala Val Trp Ile Pro Pro Ala Trp 
        35                  40                  45              


Lys Gly Ala Ser Gln Asn Asp Val Gly Tyr Gly Ala Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Arg Ser Gln Leu Gln Ala Ala Val Thr Ser Leu Lys Asn Asn Gly 
                85                  90                  95      


Ile Gln Val Tyr Gly Asp Val Val Met Asn His Lys Ala Gly Ala Asp 
            100                 105                 110         


Ala Thr Glu Asp Val Thr Ala Val Glu Val Asn Pro Ala Asn Arg Asn 
        115                 120                 125             


Gln Glu Thr Ser Glu Glu Tyr Gln Ile Lys Ala Trp Thr Asp Phe Arg 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Asp Phe Lys Trp His Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Ala Asp Trp Asp Glu Ser Arg Lys Ile Ser Arg Ile 
                165                 170                 175     


Phe Lys Phe Arg Gly Glu Gly Lys Ala Trp Asp Trp Glu Val Ser Ser 
            180                 185                 190         


Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Val Asp Met Asp 
        195                 200                 205             


His Pro Glu Val Val Asn Glu Leu Arg Asn Trp Gly Val Trp Tyr Thr 
    210                 215                 220                 


Asn Thr Leu Gly Leu Asp Gly Phe Arg Ile Asp Ala Val Lys His Ile 
225                 230                 235                 240 


Lys Tyr Ser Phe Thr Arg Asp Trp Ile Asn His Val Arg Ser Ala Thr 
                245                 250                 255     


Gly Lys Asn Met Phe Ala Val Ala Glu Phe Trp Lys Asn Asp Leu Gly 
            260                 265                 270         


Ala Ile Glu Asn Tyr Leu Gln Lys Thr Asn Trp Asn His Ser Val Phe 
        275                 280                 285             


Asp Val Pro Leu His Tyr Asn Leu Tyr Asn Ala Ser Lys Ser Gly Gly 
    290                 295                 300                 


Asn Tyr Asp Met Arg Asn Ile Phe Asn Gly Thr Val Val Gln Arg His 
305                 310                 315                 320 


Pro Ser His Ala Val Thr Phe Val Asp Asn His Asp Ser Gln Pro Glu 
                325                 330                 335     


Glu Ala Leu Glu Ser Phe Val Glu Glu Trp Phe Lys Pro Leu Ala Tyr 
            340                 345                 350         


Ala Leu Thr Leu Thr Arg Glu Gln Gly Tyr Pro Ser Val Phe Tyr Gly 
        355                 360                 365             


Asp Tyr Tyr Gly Ile Pro Thr His Gly Val Pro Ala Met Arg Ser Lys 
    370                 375                 380                 


Ile Asp Pro Ile Leu Glu Ala Arg Gln Lys Tyr Ala Tyr Gly Lys Gln 
385                 390                 395                 400 


Asn Asp Tyr Leu Asp His His Asn Ile Ile Gly Trp Thr Arg Glu Gly 
                405                 410                 415     


Asn Thr Ala His Pro Asn Ser Gly Leu Ala Thr Ile Met Ser Asp Gly 
            420                 425                 430         


Ala Gly Gly Ser Lys Trp Met Phe Val Gly Arg Asn Lys Ala Gly Gln 
        435                 440                 445             


Val Trp Ser Asp Ile Thr Gly Asn Arg Thr Gly Thr Val Thr Ile Asn 
    450                 455                 460                 


Ala Asp Gly Trp Gly Asn Phe Ser Val Asn Gly Gly Ser Val Ser Ile 
465                 470                 475                 480 


Trp Val Asn Lys 
                


<210>  186
<211>  482
<212>  PRT
<213>  Artifical Sequence

<400>  186

His His Asn Gly Thr Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr 
1               5                   10                  15      


Leu Pro Asn Asp Gly Asn His Trp Asn Arg Leu Asn Ser Asp Ala Ser 
            20                  25                  30          


Asn Leu Lys Ser Lys Gly Ile Thr Ala Val Trp Ile Pro Pro Ala Trp 
        35                  40                  45              


Lys Gly Ala Ser Gln Asn Asp Val Gly Tyr Gly Ala Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Arg Ser Gln Leu Gln Ala Ala Val Thr Ser Leu Lys Asn Asn Gly 
                85                  90                  95      


Ile Gln Val Tyr Gly Asp Val Val Met Asn His Lys Gly Gly Ala Asp 
            100                 105                 110         


Ala Thr Glu Asp Val Thr Ala Val Glu Val Asp Pro Ala Asp Arg Asn 
        115                 120                 125             


Arg Val Ile Ser Gly Glu His Leu Ile Lys Ala Trp Thr His Phe His 
    130                 135                 140                 


Phe Pro Gly Arg Gly Ser Thr Tyr Ser Asp Phe Lys Trp His Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Glu Ser Arg Lys Leu Asn Arg Ile 
                165                 170                 175     


Tyr Lys Phe Gln Gly Lys Ala Trp Asp Trp Glu Val Ser Asn Glu Phe 
            180                 185                 190         


Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Ile Asp Met Asp His Pro 
        195                 200                 205             


Glu Val Val Asn Glu Leu Arg Asn Trp Gly Val Trp Tyr Thr Asn Thr 
    210                 215                 220                 


Leu Gly Leu Asp Gly Phe Arg Ile Asp Ala Val Lys His Ile Lys Tyr 
225                 230                 235                 240 


Ser Phe Thr Arg Asp Trp Ile Asn His Val Arg Ser Ala Thr Gly Lys 
                245                 250                 255     


Asn Met Phe Ala Val Ala Glu Phe Trp Lys Asn Asp Leu Gly Ala Ile 
            260                 265                 270         


Glu Asn Tyr Leu Gln Lys Thr Asn Trp Asn His Ser Val Phe Asp Val 
        275                 280                 285             


Pro Leu His Tyr Asn Leu Tyr Asn Ala Ser Lys Ser Gly Gly Asn Tyr 
    290                 295                 300                 


Asp Met Arg Asn Ile Phe Asn Gly Thr Val Val Gln Arg His Pro Ser 
305                 310                 315                 320 


His Ala Val Thr Phe Val Asp Asn His Asp Ser Gln Pro Glu Glu Ala 
                325                 330                 335     


Leu Glu Ser Phe Val Glu Glu Trp Phe Lys Pro Leu Ala Tyr Ala Leu 
            340                 345                 350         


Thr Leu Thr Arg Glu Gln Gly Tyr Pro Ser Val Phe Tyr Gly Asp Tyr 
        355                 360                 365             


Tyr Gly Ile Pro Thr His Gly Val Pro Ala Met Arg Ser Lys Ile Asp 
    370                 375                 380                 


Pro Ile Leu Glu Ala Arg Gln Lys Tyr Ala Tyr Gly Lys Gln Asn Asp 
385                 390                 395                 400 


Tyr Leu Asp His His Asn Ile Ile Gly Trp Thr Arg Glu Gly Asn Thr 
                405                 410                 415     


Ala His Pro Asn Ser Gly Leu Ala Thr Ile Met Ser Asp Gly Ala Gly 
            420                 425                 430         


Gly Ser Lys Trp Met Phe Val Gly Arg Asn Lys Ala Gly Gln Val Trp 
        435                 440                 445             


Ser Asp Ile Thr Gly Asn Arg Thr Gly Thr Val Thr Ile Asn Ala Asp 
    450                 455                 460                 


Gly Trp Gly Asn Phe Ser Val Asn Gly Gly Ser Val Ser Ile Trp Val 
465                 470                 475                 480 


Asn Lys 
        


<210>  187
<211>  484
<212>  PRT
<213>  Artifical Sequence

<400>  187

His His Asn Gly Thr Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr 
1               5                   10                  15      


Leu Pro Asn Asp Gly Asn His Trp Asn Arg Leu Asn Ser Asp Ala Ser 
            20                  25                  30          


Asn Leu Lys Ser Lys Gly Ile Thr Ala Val Trp Ile Pro Pro Ala Trp 
        35                  40                  45              


Lys Gly Ala Ser Gln Asn Asp Val Gly Tyr Gly Ala Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Arg Ser Gln Leu Gln Ala Ala Val Thr Ser Leu Lys Asn Asn Gly 
                85                  90                  95      


Ile Gln Val Tyr Gly Asp Val Val Met Asn His Lys Ala Gly Ala Asp 
            100                 105                 110         


Tyr Thr Glu Asn Val Thr Ala Val Glu Val Asn Pro Ser Asn Arg Asn 
        115                 120                 125             


Gln Glu Thr Ser Gly Glu Tyr Asn Ile Gln Ala Trp Thr Gly Phe Asn 
    130                 135                 140                 


Phe Pro Gly Arg Gly Thr Thr Tyr Ser Asn Phe Lys Trp Gln Trp Phe 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Gln Ser Arg Ser Leu Ser Arg Ile 
                165                 170                 175     


Phe Lys Phe Arg Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Ser Ser 
            180                 185                 190         


Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Ile Asp Met Asp 
        195                 200                 205             


His Pro Glu Val Val Asn Glu Leu Arg Asn Trp Gly Val Trp Tyr Thr 
    210                 215                 220                 


Asn Thr Leu Gly Leu Asp Gly Phe Arg Ile Asp Ala Val Lys His Ile 
225                 230                 235                 240 


Lys Tyr Ser Phe Thr Arg Asp Trp Ile Asn His Val Arg Ser Ala Thr 
                245                 250                 255     


Gly Lys Asn Met Phe Ala Val Ala Glu Phe Trp Lys Asn Asp Leu Gly 
            260                 265                 270         


Ala Ile Glu Asn Tyr Leu Gln Lys Thr Asn Trp Asn His Ser Val Phe 
        275                 280                 285             


Asp Val Pro Leu His Tyr Asn Leu Tyr Asn Ala Ser Lys Ser Gly Gly 
    290                 295                 300                 


Asn Tyr Asp Met Arg Asn Ile Phe Asn Gly Thr Val Val Gln Arg His 
305                 310                 315                 320 


Pro Ser His Ala Val Thr Phe Val Asp Asn His Asp Ser Gln Pro Glu 
                325                 330                 335     


Glu Ala Leu Glu Ser Phe Val Glu Glu Trp Phe Lys Pro Leu Ala Tyr 
            340                 345                 350         


Ala Leu Thr Leu Thr Arg Glu Gln Gly Tyr Pro Ser Val Phe Tyr Gly 
        355                 360                 365             


Asp Tyr Tyr Gly Ile Pro Thr His Gly Val Pro Ala Met Arg Ser Lys 
    370                 375                 380                 


Ile Asp Pro Ile Leu Glu Ala Arg Gln Lys Tyr Ala Tyr Gly Lys Gln 
385                 390                 395                 400 


Asn Asp Tyr Leu Asp His His Asn Ile Ile Gly Trp Thr Arg Glu Gly 
                405                 410                 415     


Asn Thr Ala His Pro Asn Ser Gly Leu Ala Thr Ile Met Ser Asp Gly 
            420                 425                 430         


Ala Gly Gly Ser Lys Trp Met Phe Val Gly Arg Asn Lys Ala Gly Gln 
        435                 440                 445             


Val Trp Ser Asp Ile Thr Gly Asn Arg Thr Gly Thr Val Thr Ile Asn 
    450                 455                 460                 


Ala Asp Gly Trp Gly Asn Phe Ser Val Asn Gly Gly Ser Val Ser Ile 
465                 470                 475                 480 


Trp Val Asn Lys 
                


<210>  188
<211>  484
<212>  PRT
<213>  Artifical Sequence

<400>  188

His His Asn Gly Thr Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr 
1               5                   10                  15      


Leu Pro Asn Asp Gly Asn His Trp Asn Arg Leu Asn Ser Asp Ala Ser 
            20                  25                  30          


Asn Leu Lys Ser Lys Gly Ile Thr Ala Val Trp Ile Pro Pro Ala Trp 
        35                  40                  45              


Lys Gly Ala Ser Gln Asn Asp Val Gly Tyr Gly Ala Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Arg Ser Gln Leu Gln Ala Ala Val Thr Ser Leu Lys Asn Asn Gly 
                85                  90                  95      


Ile Gln Val Tyr Gly Asp Val Val Met Asp His Lys Gly Gly Ala Asp 
            100                 105                 110         


Gly Thr Glu Trp Val Asp Ala Val Glu Val Asn Pro Ser Asp Arg Asn 
        115                 120                 125             


Gln Glu Ile Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Val Asp Trp Asp Glu Ser Arg Lys Leu Ser Arg Ile 
                165                 170                 175     


Tyr Lys Phe Arg Gly Ile Gly Lys Ala Trp Asp Trp Glu Val Asp Thr 
            180                 185                 190         


Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Leu Asp Met Asp 
        195                 200                 205             


His Pro Glu Val Val Asn Glu Leu Arg Asn Trp Gly Val Trp Tyr Thr 
    210                 215                 220                 


Asn Thr Leu Gly Leu Asp Gly Phe Arg Ile Asp Ala Val Lys His Ile 
225                 230                 235                 240 


Lys Tyr Ser Phe Thr Arg Asp Trp Ile Asn His Val Arg Ser Ala Thr 
                245                 250                 255     


Gly Lys Asn Met Phe Ala Val Ala Glu Phe Trp Lys Asn Asp Leu Gly 
            260                 265                 270         


Ala Ile Glu Asn Tyr Leu Gln Lys Thr Asn Trp Asn His Ser Val Phe 
        275                 280                 285             


Asp Val Pro Leu His Tyr Asn Leu Tyr Asn Ala Ser Lys Ser Gly Gly 
    290                 295                 300                 


Asn Tyr Asp Met Arg Asn Ile Phe Asn Gly Thr Val Val Gln Arg His 
305                 310                 315                 320 


Pro Ser His Ala Val Thr Phe Val Asp Asn His Asp Ser Gln Pro Glu 
                325                 330                 335     


Glu Ala Leu Glu Ser Phe Val Glu Glu Trp Phe Lys Pro Leu Ala Tyr 
            340                 345                 350         


Ala Leu Thr Leu Thr Arg Glu Gln Gly Tyr Pro Ser Val Phe Tyr Gly 
        355                 360                 365             


Asp Tyr Tyr Gly Ile Pro Thr His Gly Val Pro Ala Met Arg Ser Lys 
    370                 375                 380                 


Ile Asp Pro Ile Leu Glu Ala Arg Gln Lys Tyr Ala Tyr Gly Lys Gln 
385                 390                 395                 400 


Asn Asp Tyr Leu Asp His His Asn Ile Ile Gly Trp Thr Arg Glu Gly 
                405                 410                 415     


Asn Thr Ala His Pro Asn Ser Gly Leu Ala Thr Ile Met Ser Asp Gly 
            420                 425                 430         


Ala Gly Gly Ser Lys Trp Met Phe Val Gly Arg Asn Lys Ala Gly Gln 
        435                 440                 445             


Val Trp Ser Asp Ile Thr Gly Asn Arg Thr Gly Thr Val Thr Ile Asn 
    450                 455                 460                 


Ala Asp Gly Trp Gly Asn Phe Ser Val Asn Gly Gly Ser Val Ser Ile 
465                 470                 475                 480 


Trp Val Asn Lys 
                


<210>  189
<211>  484
<212>  PRT
<213>  Artifical Sequence

<400>  189

His His Asn Gly Thr Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr 
1               5                   10                  15      


Leu Pro Asn Asp Gly Asn His Trp Asn Arg Leu Asn Ser Asp Ala Ser 
            20                  25                  30          


Asn Leu Lys Ser Lys Gly Ile Thr Ala Val Trp Ile Pro Pro Ala Trp 
        35                  40                  45              


Lys Gly Ala Ser Gln Asn Asp Val Gly Tyr Gly Ala Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Arg Ser Gln Leu Gln Ala Ala Val Thr Ser Leu Lys Asn Asn Gly 
                85                  90                  95      


Ile Gln Val Tyr Gly Asp Val Val Met Asn His Lys Ala Gly Ala Asp 
            100                 105                 110         


Gly Thr Glu Leu Val Asp Ala Val Glu Val Asn Pro Ser Asp Arg Asn 
        115                 120                 125             


Gln Glu Ile Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Glu Ser Arg Lys Leu Asn Arg Ile 
                165                 170                 175     


Tyr Lys Phe Arg Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Asp Thr 
            180                 185                 190         


Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Leu Asp Met Asp 
        195                 200                 205             


His Pro Glu Val Val Asn Glu Leu Arg Asn Trp Gly Val Trp Tyr Thr 
    210                 215                 220                 


Asn Thr Leu Gly Leu Asp Gly Phe Arg Ile Asp Ala Val Lys His Ile 
225                 230                 235                 240 


Lys Tyr Ser Phe Thr Arg Asp Trp Ile Asn His Val Arg Ser Ala Thr 
                245                 250                 255     


Gly Lys Asn Met Phe Ala Val Ala Glu Phe Trp Lys Asn Asp Leu Gly 
            260                 265                 270         


Ala Ile Glu Asn Tyr Leu Gln Lys Thr Asn Trp Asn His Ser Val Phe 
        275                 280                 285             


Asp Val Pro Leu His Tyr Asn Leu Tyr Asn Ala Ser Lys Ser Gly Gly 
    290                 295                 300                 


Asn Tyr Asp Met Arg Asn Ile Phe Asn Gly Thr Val Val Gln Arg His 
305                 310                 315                 320 


Pro Ser His Ala Val Thr Phe Val Asp Asn His Asp Ser Gln Pro Glu 
                325                 330                 335     


Glu Ala Leu Glu Ser Phe Val Glu Glu Trp Phe Lys Pro Leu Ala Tyr 
            340                 345                 350         


Ala Leu Thr Leu Thr Arg Glu Gln Gly Tyr Pro Ser Val Phe Tyr Gly 
        355                 360                 365             


Asp Tyr Tyr Gly Ile Pro Thr His Gly Val Pro Ala Met Arg Ser Lys 
    370                 375                 380                 


Ile Asp Pro Ile Leu Glu Ala Arg Gln Lys Tyr Ala Tyr Gly Lys Gln 
385                 390                 395                 400 


Asn Asp Tyr Leu Asp His His Asn Ile Ile Gly Trp Thr Arg Glu Gly 
                405                 410                 415     


Asn Thr Ala His Pro Asn Ser Gly Leu Ala Thr Ile Met Ser Asp Gly 
            420                 425                 430         


Ala Gly Gly Ser Lys Trp Met Phe Val Gly Arg Asn Lys Ala Gly Gln 
        435                 440                 445             


Val Trp Ser Asp Ile Thr Gly Asn Arg Thr Gly Thr Val Thr Ile Asn 
    450                 455                 460                 


Ala Asp Gly Trp Gly Asn Phe Ser Val Asn Gly Gly Ser Val Ser Ile 
465                 470                 475                 480 


Trp Val Asn Lys 
                


<210>  190
<211>  484
<212>  PRT
<213>  Artifical Sequence

<400>  190

His His Asn Gly Thr Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr 
1               5                   10                  15      


Leu Pro Asn Asp Gly Asn His Trp Asn Arg Leu Asn Ser Asp Ala Ser 
            20                  25                  30          


Asn Leu Lys Ser Lys Gly Ile Thr Ala Val Trp Ile Pro Pro Ala Trp 
        35                  40                  45              


Lys Gly Ala Ser Gln Asn Asp Val Gly Tyr Gly Ala Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Arg Ser Gln Leu Gln Ala Ala Val Thr Ser Leu Lys Asn Asn Gly 
                85                  90                  95      


Ile Gln Val Tyr Gly Asp Val Val Met Asn His Lys Ala Gly Ala Asp 
            100                 105                 110         


Gly Thr Glu Phe Val Asp Ala Val Glu Val Asn Pro Ser Asn Arg Asn 
        115                 120                 125             


Gln Glu Thr Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Glu Ser Arg Lys Leu Asn Arg Val 
                165                 170                 175     


Tyr Lys Phe Arg Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Asp Thr 
            180                 185                 190         


Glu Asn Gly Asn Tyr Asp Tyr Leu Met Phe Ala Asp Leu Asp Met Asp 
        195                 200                 205             


His Pro Glu Val Val Asn Glu Leu Arg Asn Trp Gly Val Trp Tyr Thr 
    210                 215                 220                 


Asn Thr Leu Gly Leu Asp Gly Phe Arg Ile Asp Ala Val Lys His Ile 
225                 230                 235                 240 


Lys Tyr Ser Phe Thr Arg Asp Trp Ile Asn His Val Arg Ser Ala Thr 
                245                 250                 255     


Gly Lys Asn Met Phe Ala Val Ala Glu Phe Trp Lys Asn Asp Leu Gly 
            260                 265                 270         


Ala Ile Glu Asn Tyr Leu Gln Lys Thr Asn Trp Asn His Ser Val Phe 
        275                 280                 285             


Asp Val Pro Leu His Tyr Asn Leu Tyr Asn Ala Ser Lys Ser Gly Gly 
    290                 295                 300                 


Asn Tyr Asp Met Arg Asn Ile Phe Asn Gly Thr Val Val Gln Arg His 
305                 310                 315                 320 


Pro Ser His Ala Val Thr Phe Val Asp Asn His Asp Ser Gln Pro Glu 
                325                 330                 335     


Glu Ala Leu Glu Ser Phe Val Glu Glu Trp Phe Lys Pro Leu Ala Tyr 
            340                 345                 350         


Ala Leu Thr Leu Thr Arg Glu Gln Gly Tyr Pro Ser Val Phe Tyr Gly 
        355                 360                 365             


Asp Tyr Tyr Gly Ile Pro Thr His Gly Val Pro Ala Met Arg Ser Lys 
    370                 375                 380                 


Ile Asp Pro Ile Leu Glu Ala Arg Gln Lys Tyr Ala Tyr Gly Lys Gln 
385                 390                 395                 400 


Asn Asp Tyr Leu Asp His His Asn Ile Ile Gly Trp Thr Arg Glu Gly 
                405                 410                 415     


Asn Thr Ala His Pro Asn Ser Gly Leu Ala Thr Ile Met Ser Asp Gly 
            420                 425                 430         


Ala Gly Gly Ser Lys Trp Met Phe Val Gly Arg Asn Lys Ala Gly Gln 
        435                 440                 445             


Val Trp Ser Asp Ile Thr Gly Asn Arg Thr Gly Thr Val Thr Ile Asn 
    450                 455                 460                 


Ala Asp Gly Trp Gly Asn Phe Ser Val Asn Gly Gly Ser Val Ser Ile 
465                 470                 475                 480 


Trp Val Asn Lys 
                


<210>  191
<211>  483
<212>  PRT
<213>  Artifical Sequence

<400>  191

His His Asn Gly Thr Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr 
1               5                   10                  15      


Leu Pro Asn Asp Gly Asn His Trp Asn Arg Leu Asn Ser Asp Ala Ser 
            20                  25                  30          


Asn Leu Lys Ser Lys Gly Ile Thr Ala Val Trp Ile Pro Pro Ala Trp 
        35                  40                  45              


Lys Gly Ala Ser Gln Asn Asp Val Gly Tyr Gly Ala Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Arg Ser Gln Leu Gln Ala Ala Val Thr Ser Leu Lys Asn Asn Gly 
                85                  90                  95      


Ile Gln Val Tyr Gly Asp Val Val Met Asn His Lys Ala Gly Ala Asp 
            100                 105                 110         


Gly Thr Glu Phe Val Asp Ala Val Glu Val Asp Pro Ser Asn Arg Asn 
        115                 120                 125             


Gln Glu Thr Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Glu Ser Arg Lys Leu Asn Arg Ile 
                165                 170                 175     


Tyr Lys Phe Ser Thr Gly Lys Ala Trp Asp Trp Glu Val Asp Thr Glu 
            180                 185                 190         


Asn Gly Asn Tyr Asp Tyr Leu Met Phe Ala Asp Leu Asp Met Asp His 
        195                 200                 205             


Pro Glu Val Val Asn Glu Leu Arg Asn Trp Gly Val Trp Tyr Thr Asn 
    210                 215                 220                 


Thr Leu Gly Leu Asp Gly Phe Arg Ile Asp Ala Val Lys His Ile Lys 
225                 230                 235                 240 


Tyr Ser Phe Thr Arg Asp Trp Ile Asn His Val Arg Ser Ala Thr Gly 
                245                 250                 255     


Lys Asn Met Phe Ala Val Ala Glu Phe Trp Lys Asn Asp Leu Gly Ala 
            260                 265                 270         


Ile Glu Asn Tyr Leu Gln Lys Thr Asn Trp Asn His Ser Val Phe Asp 
        275                 280                 285             


Val Pro Leu His Tyr Asn Leu Tyr Asn Ala Ser Lys Ser Gly Gly Asn 
    290                 295                 300                 


Tyr Asp Met Arg Asn Ile Phe Asn Gly Thr Val Val Gln Arg His Pro 
305                 310                 315                 320 


Ser His Ala Val Thr Phe Val Asp Asn His Asp Ser Gln Pro Glu Glu 
                325                 330                 335     


Ala Leu Glu Ser Phe Val Glu Glu Trp Phe Lys Pro Leu Ala Tyr Ala 
            340                 345                 350         


Leu Thr Leu Thr Arg Glu Gln Gly Tyr Pro Ser Val Phe Tyr Gly Asp 
        355                 360                 365             


Tyr Tyr Gly Ile Pro Thr His Gly Val Pro Ala Met Arg Ser Lys Ile 
    370                 375                 380                 


Asp Pro Ile Leu Glu Ala Arg Gln Lys Tyr Ala Tyr Gly Lys Gln Asn 
385                 390                 395                 400 


Asp Tyr Leu Asp His His Asn Ile Ile Gly Trp Thr Arg Glu Gly Asn 
                405                 410                 415     


Thr Ala His Pro Asn Ser Gly Leu Ala Thr Ile Met Ser Asp Gly Ala 
            420                 425                 430         


Gly Gly Ser Lys Trp Met Phe Val Gly Arg Asn Lys Ala Gly Gln Val 
        435                 440                 445             


Trp Ser Asp Ile Thr Gly Asn Arg Thr Gly Thr Val Thr Ile Asn Ala 
    450                 455                 460                 


Asp Gly Trp Gly Asn Phe Ser Val Asn Gly Gly Ser Val Ser Ile Trp 
465                 470                 475                 480 


Val Asn Lys 
            


<210>  192
<211>  484
<212>  PRT
<213>  Artifical Sequence

<400>  192

His His Asn Gly Thr Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr 
1               5                   10                  15      


Leu Pro Asn Asp Gly Asn His Trp Asn Arg Leu Asn Ser Asp Ala Ser 
            20                  25                  30          


Asn Leu Lys Ser Lys Gly Ile Thr Ala Val Trp Ile Pro Pro Ala Trp 
        35                  40                  45              


Lys Gly Ala Ser Gln Asn Asp Val Gly Tyr Gly Ala Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Arg Ser Gln Leu Gln Ala Ala Val Thr Ser Leu Lys Asn Asn Gly 
                85                  90                  95      


Ile Gln Val Tyr Gly Asp Val Val Met Asn His Lys Ala Gly Ala Asp 
            100                 105                 110         


Gly Thr Glu Phe Val Asp Ala Val Glu Val Asn Pro Ser Asn Arg Asn 
        115                 120                 125             


Gln Glu Thr Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Glu Ser Arg Lys Leu Asn Arg Ile 
                165                 170                 175     


Tyr Lys Phe Arg Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Asp Thr 
            180                 185                 190         


Glu Asn Gly Asn Tyr Asp Tyr Leu Met Phe Ala Asp Leu Asp Met Asp 
        195                 200                 205             


His Pro Glu Val Val Asn Glu Leu Arg Asn Trp Gly Val Trp Tyr Thr 
    210                 215                 220                 


Asn Thr Leu Gly Leu Asp Gly Phe Arg Ile Asp Ala Val Lys His Ile 
225                 230                 235                 240 


Lys Tyr Ser Phe Thr Arg Asp Trp Ile Asn His Val Arg Ser Ala Thr 
                245                 250                 255     


Gly Lys Asn Met Phe Ala Val Ala Glu Phe Trp Lys Asn Asp Leu Gly 
            260                 265                 270         


Ala Ile Glu Asn Tyr Leu Gln Lys Thr Asn Trp Asn His Ser Val Phe 
        275                 280                 285             


Asp Val Pro Leu His Tyr Asn Leu Tyr Asn Ala Ser Lys Ser Gly Gly 
    290                 295                 300                 


Asn Tyr Asp Met Arg Asn Ile Phe Asn Gly Thr Val Val Gln Arg His 
305                 310                 315                 320 


Pro Ser His Ala Val Thr Phe Val Asp Asn His Asp Ser Gln Pro Glu 
                325                 330                 335     


Glu Ala Leu Glu Ser Phe Val Glu Glu Trp Phe Lys Pro Leu Ala Tyr 
            340                 345                 350         


Ala Leu Thr Leu Thr Arg Glu Gln Gly Tyr Pro Ser Val Phe Tyr Gly 
        355                 360                 365             


Asp Tyr Tyr Gly Ile Pro Thr His Gly Val Pro Ala Met Arg Ser Lys 
    370                 375                 380                 


Ile Asp Pro Ile Leu Glu Ala Arg Gln Lys Tyr Ala Tyr Gly Lys Gln 
385                 390                 395                 400 


Asn Asp Tyr Leu Asp His His Asn Ile Ile Gly Trp Thr Arg Glu Gly 
                405                 410                 415     


Asn Thr Ala His Pro Asn Ser Gly Leu Ala Thr Ile Met Ser Asp Gly 
            420                 425                 430         


Ala Gly Gly Ser Lys Trp Met Phe Val Gly Arg Asn Lys Ala Gly Gln 
        435                 440                 445             


Val Trp Ser Asp Ile Thr Gly Asn Arg Thr Gly Thr Val Thr Ile Asn 
    450                 455                 460                 


Ala Asp Gly Trp Gly Asn Phe Ser Val Asn Gly Gly Ser Val Ser Ile 
465                 470                 475                 480 


Trp Val Asn Lys 
                


<210>  193
<211>  484
<212>  PRT
<213>  Artifiical Sequence

<400>  193

His His Asn Gly Thr Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr 
1               5                   10                  15      


Leu Pro Asn Asp Gly Asn His Trp Asn Arg Leu Asn Ser Asp Ala Ser 
            20                  25                  30          


Asn Leu Lys Ser Lys Gly Ile Thr Ala Val Trp Ile Pro Pro Ala Trp 
        35                  40                  45              


Lys Gly Ala Ser Gln Asn Asp Val Gly Tyr Gly Ala Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Arg Ser Gln Leu Gln Ala Ala Val Thr Ser Leu Lys Asn Asn Gly 
                85                  90                  95      


Ile Gln Val Tyr Gly Asp Val Val Met Asn His Lys Ala Gly Ala Asp 
            100                 105                 110         


Ala Thr Glu Trp Val Asp Ala Val Glu Val Asn Pro Ser Asn Arg Asn 
        115                 120                 125             


Gln Glu Val Ser Gly Thr Tyr Lys Ile Gln Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Gln Ser Arg Gln Leu Asn Arg Ile 
                165                 170                 175     


Tyr Lys Phe Arg Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Asp Thr 
            180                 185                 190         


Glu Asn Gly Asn Tyr Asp Tyr Leu Met Phe Ala Asp Leu Asp Met Asp 
        195                 200                 205             


His Pro Glu Val Val Asn Glu Leu Arg Asn Trp Gly Val Trp Tyr Thr 
    210                 215                 220                 


Asn Thr Leu Gly Leu Asp Gly Phe Arg Ile Asp Ala Val Lys His Ile 
225                 230                 235                 240 


Lys Tyr Ser Phe Thr Arg Asp Trp Ile Asn His Val Arg Ser Ala Thr 
                245                 250                 255     


Gly Lys Asn Met Phe Ala Val Ala Glu Phe Trp Lys Asn Asp Leu Gly 
            260                 265                 270         


Ala Ile Glu Asn Tyr Leu Gln Lys Thr Asn Trp Asn His Ser Val Phe 
        275                 280                 285             


Asp Val Pro Leu His Tyr Asn Leu Tyr Asn Ala Ser Lys Ser Gly Gly 
    290                 295                 300                 


Asn Tyr Asp Met Arg Asn Ile Phe Asn Gly Thr Val Val Gln Arg His 
305                 310                 315                 320 


Pro Ser His Ala Val Thr Phe Val Asp Asn His Asp Ser Gln Pro Glu 
                325                 330                 335     


Glu Ala Leu Glu Ser Phe Val Glu Glu Trp Phe Lys Pro Leu Ala Tyr 
            340                 345                 350         


Ala Leu Thr Leu Thr Arg Glu Gln Gly Tyr Pro Ser Val Phe Tyr Gly 
        355                 360                 365             


Asp Tyr Tyr Gly Ile Pro Thr His Gly Val Pro Ala Met Arg Ser Lys 
    370                 375                 380                 


Ile Asp Pro Ile Leu Glu Ala Arg Gln Lys Tyr Ala Tyr Gly Lys Gln 
385                 390                 395                 400 


Asn Asp Tyr Leu Asp His His Asn Ile Ile Gly Trp Thr Arg Glu Gly 
                405                 410                 415     


Asn Thr Ala His Pro Asn Ser Gly Leu Ala Thr Ile Met Ser Asp Gly 
            420                 425                 430         


Ala Gly Gly Ser Lys Trp Met Phe Val Gly Arg Asn Lys Ala Gly Gln 
        435                 440                 445             


Val Trp Ser Asp Ile Thr Gly Asn Arg Thr Gly Thr Val Thr Ile Asn 
    450                 455                 460                 


Ala Asp Gly Trp Gly Asn Phe Ser Val Asn Gly Gly Ser Val Ser Ile 
465                 470                 475                 480 


Trp Val Asn Lys 
                


<210>  194
<211>  484
<212>  PRT
<213>  Artifical Sequence

<400>  194

His His Asn Gly Thr Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr 
1               5                   10                  15      


Leu Pro Asn Asp Gly Asn His Trp Asn Arg Leu Asn Ser Asp Ala Ser 
            20                  25                  30          


Asn Leu Lys Ser Lys Gly Ile Thr Ala Val Trp Ile Pro Pro Ala Trp 
        35                  40                  45              


Lys Gly Ala Ser Gln Asn Asp Val Gly Tyr Gly Ala Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Arg Ser Gln Leu Gln Ala Ala Val Thr Ser Leu Lys Asn Asn Gly 
                85                  90                  95      


Ile Gln Val Tyr Gly Asp Val Val Met Asn His Lys Ala Gly Ala Asp 
            100                 105                 110         


Ser Thr Glu Trp Val Asp Ala Val Glu Val Asn Pro Ser Asn Arg Asn 
        115                 120                 125             


Gln Glu Thr Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Glu Ser Arg Lys Leu Asn Arg Ile 
                165                 170                 175     


Tyr Lys Phe Arg Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Asp Thr 
            180                 185                 190         


Glu Asn Gly Asn Tyr Asp Tyr Leu Met Phe Ala Asp Leu Asp Met Asp 
        195                 200                 205             


His Pro Glu Val Val Asn Glu Leu Arg Asn Trp Gly Val Trp Tyr Thr 
    210                 215                 220                 


Asn Thr Leu Gly Leu Asp Gly Phe Arg Ile Asp Ala Val Lys His Ile 
225                 230                 235                 240 


Lys Tyr Ser Phe Thr Arg Asp Trp Ile Asn His Val Arg Ser Ala Thr 
                245                 250                 255     


Gly Lys Asn Met Phe Ala Val Ala Glu Phe Trp Lys Asn Asp Leu Gly 
            260                 265                 270         


Ala Ile Glu Asn Tyr Leu Gln Lys Thr Asn Trp Asn His Ser Val Phe 
        275                 280                 285             


Asp Val Pro Leu His Tyr Asn Leu Tyr Asn Ala Ser Lys Ser Gly Gly 
    290                 295                 300                 


Asn Tyr Asp Met Arg Asn Ile Phe Asn Gly Thr Val Val Gln Arg His 
305                 310                 315                 320 


Pro Ser His Ala Val Thr Phe Val Asp Asn His Asp Ser Gln Pro Glu 
                325                 330                 335     


Glu Ala Leu Glu Ser Phe Val Glu Glu Trp Phe Lys Pro Leu Ala Tyr 
            340                 345                 350         


Ala Leu Thr Leu Thr Arg Glu Gln Gly Tyr Pro Ser Val Phe Tyr Gly 
        355                 360                 365             


Asp Tyr Tyr Gly Ile Pro Thr His Gly Val Pro Ala Met Arg Ser Lys 
    370                 375                 380                 


Ile Asp Pro Ile Leu Glu Ala Arg Gln Lys Tyr Ala Tyr Gly Lys Gln 
385                 390                 395                 400 


Asn Asp Tyr Leu Asp His His Asn Ile Ile Gly Trp Thr Arg Glu Gly 
                405                 410                 415     


Asn Thr Ala His Pro Asn Ser Gly Leu Ala Thr Ile Met Ser Asp Gly 
            420                 425                 430         


Ala Gly Gly Ser Lys Trp Met Phe Val Gly Arg Asn Lys Ala Gly Gln 
        435                 440                 445             


Val Trp Ser Asp Ile Thr Gly Asn Arg Thr Gly Thr Val Thr Ile Asn 
    450                 455                 460                 


Ala Asp Gly Trp Gly Asn Phe Ser Val Asn Gly Gly Ser Val Ser Ile 
465                 470                 475                 480 


Trp Val Asn Lys 
                


<210>  195
<211>  485
<212>  PRT
<213>  Artifical Sequence

<400>  195

His His Asn Gly Thr Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr 
1               5                   10                  15      


Leu Pro Asn Asp Gly Asn His Trp Asn Arg Leu Asn Ser Asp Ala Ser 
            20                  25                  30          


Asn Leu Lys Ser Lys Gly Ile Thr Ala Val Trp Ile Pro Pro Ala Trp 
        35                  40                  45              


Lys Gly Ala Ser Gln Asn Asp Val Gly Tyr Gly Ala Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Arg Ser Gln Leu Gln Ala Ala Val Thr Ser Leu Lys Asn Asn Gly 
                85                  90                  95      


Ile Gln Val Tyr Gly Asp Val Val Met Asn His Lys Gly Gly Ala Asp 
            100                 105                 110         


Phe Thr Glu Arg Val Gln Ala Val Glu Val Asn Pro Gln Asn Arg Asn 
        115                 120                 125             


Gln Glu Val Ser Gly Thr Tyr Gln Ile Glu Ala Trp Thr Gly Phe Asn 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Gln His Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Gln Ser Arg Gln Leu Ala Asn Arg 
                165                 170                 175     


Ile Tyr Lys Phe Arg Gly Asp Gly Lys Ala Trp Asp Trp Glu Val Asp 
            180                 185                 190         


Thr Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Val Asp Met 
        195                 200                 205             


Asp His Pro Glu Val Val Asn Glu Leu Arg Asn Trp Gly Val Trp Tyr 
    210                 215                 220                 


Thr Asn Thr Leu Gly Leu Asp Gly Phe Arg Ile Asp Ala Val Lys His 
225                 230                 235                 240 


Ile Lys Tyr Ser Phe Thr Arg Asp Trp Ile Asn His Val Arg Ser Ala 
                245                 250                 255     


Thr Gly Lys Asn Met Phe Ala Val Ala Glu Phe Trp Lys Asn Asp Leu 
            260                 265                 270         


Gly Ala Ile Glu Asn Tyr Leu Gln Lys Thr Asn Trp Asn His Ser Val 
        275                 280                 285             


Phe Asp Val Pro Leu His Tyr Asn Leu Tyr Asn Ala Ser Lys Ser Gly 
    290                 295                 300                 


Gly Asn Tyr Asp Met Arg Asn Ile Phe Asn Gly Thr Val Val Gln Arg 
305                 310                 315                 320 


His Pro Ser His Ala Val Thr Phe Val Asp Asn His Asp Ser Gln Pro 
                325                 330                 335     


Glu Glu Ala Leu Glu Ser Phe Val Glu Glu Trp Phe Lys Pro Leu Ala 
            340                 345                 350         


Tyr Ala Leu Thr Leu Thr Arg Glu Gln Gly Tyr Pro Ser Val Phe Tyr 
        355                 360                 365             


Gly Asp Tyr Tyr Gly Ile Pro Thr His Gly Val Pro Ala Met Arg Ser 
    370                 375                 380                 


Lys Ile Asp Pro Ile Leu Glu Ala Arg Gln Lys Tyr Ala Tyr Gly Lys 
385                 390                 395                 400 


Gln Asn Asp Tyr Leu Asp His His Asn Ile Ile Gly Trp Thr Arg Glu 
                405                 410                 415     


Gly Asn Thr Ala His Pro Asn Ser Gly Leu Ala Thr Ile Met Ser Asp 
            420                 425                 430         


Gly Ala Gly Gly Ser Lys Trp Met Phe Val Gly Arg Asn Lys Ala Gly 
        435                 440                 445             


Gln Val Trp Ser Asp Ile Thr Gly Asn Arg Thr Gly Thr Val Thr Ile 
    450                 455                 460                 


Asn Ala Asp Gly Trp Gly Asn Phe Ser Val Asn Gly Gly Ser Val Ser 
465                 470                 475                 480 


Ile Trp Val Asn Lys 
                485 


<210>  196
<211>  485
<212>  PRT
<213>  Artifical Sequence

<400>  196

His His Asn Gly Thr Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr 
1               5                   10                  15      


Leu Pro Asn Asp Gly Asn His Trp Asn Arg Leu Asn Ser Asp Ala Ser 
            20                  25                  30          


Asn Leu Lys Ser Lys Gly Ile Thr Ala Val Trp Ile Pro Pro Ala Trp 
        35                  40                  45              


Lys Gly Ala Ser Gln Asn Asp Val Gly Tyr Gly Ala Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Arg Ser Gln Leu Gln Ala Ala Val Thr Ser Leu Lys Asn Asn Gly 
                85                  90                  95      


Ile Gln Val Tyr Gly Asp Val Val Met Asn His Lys Gly Gly Ala Asp 
            100                 105                 110         


Ala Thr Glu Asn Val Leu Ala Val Glu Val Asn Pro Asn Asn Arg Asn 
        115                 120                 125             


Gln Glu Ile Ser Gly Asp Tyr Thr Ile Glu Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Asp Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Val Asp Trp Asp Gln Ser Arg Gln Phe Gln Asn Arg 
                165                 170                 175     


Ile Tyr Lys Phe Arg Gly Asp Gly Lys Ala Trp Asp Trp Glu Val Asp 
            180                 185                 190         


Ser Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Val Asp Met 
        195                 200                 205             


Asp His Pro Glu Val Val Asn Glu Leu Arg Asn Trp Gly Val Trp Tyr 
    210                 215                 220                 


Thr Asn Thr Leu Gly Leu Asp Gly Phe Arg Ile Asp Ala Val Lys His 
225                 230                 235                 240 


Ile Lys Tyr Ser Phe Thr Arg Asp Trp Ile Asn His Val Arg Ser Ala 
                245                 250                 255     


Thr Gly Lys Asn Met Phe Ala Val Ala Glu Phe Trp Lys Asn Asp Leu 
            260                 265                 270         


Gly Ala Ile Glu Asn Tyr Leu Gln Lys Thr Asn Trp Asn His Ser Val 
        275                 280                 285             


Phe Asp Val Pro Leu His Tyr Asn Leu Tyr Asn Ala Ser Lys Ser Gly 
    290                 295                 300                 


Gly Asn Tyr Asp Met Arg Asn Ile Phe Asn Gly Thr Val Val Gln Arg 
305                 310                 315                 320 


His Pro Ser His Ala Val Thr Phe Val Asp Asn His Asp Ser Gln Pro 
                325                 330                 335     


Glu Glu Ala Leu Glu Ser Phe Val Glu Glu Trp Phe Lys Pro Leu Ala 
            340                 345                 350         


Tyr Ala Leu Thr Leu Thr Arg Glu Gln Gly Tyr Pro Ser Val Phe Tyr 
        355                 360                 365             


Gly Asp Tyr Tyr Gly Ile Pro Thr His Gly Val Pro Ala Met Arg Ser 
    370                 375                 380                 


Lys Ile Asp Pro Ile Leu Glu Ala Arg Gln Lys Tyr Ala Tyr Gly Lys 
385                 390                 395                 400 


Gln Asn Asp Tyr Leu Asp His His Asn Ile Ile Gly Trp Thr Arg Glu 
                405                 410                 415     


Gly Asn Thr Ala His Pro Asn Ser Gly Leu Ala Thr Ile Met Ser Asp 
            420                 425                 430         


Gly Ala Gly Gly Ser Lys Trp Met Phe Val Gly Arg Asn Lys Ala Gly 
        435                 440                 445             


Gln Val Trp Ser Asp Ile Thr Gly Asn Arg Thr Gly Thr Val Thr Ile 
    450                 455                 460                 


Asn Ala Asp Gly Trp Gly Asn Phe Ser Val Asn Gly Gly Ser Val Ser 
465                 470                 475                 480 


Ile Trp Val Asn Lys 
                485 


<210>  197
<211>  485
<212>  PRT
<213>  Artifical Sequence

<400>  197

His His Asn Gly Thr Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr 
1               5                   10                  15      


Leu Pro Asn Asp Gly Asn His Trp Asn Arg Leu Asn Ser Asp Ala Ser 
            20                  25                  30          


Asn Leu Lys Ser Lys Gly Ile Thr Ala Val Trp Ile Pro Pro Ala Trp 
        35                  40                  45              


Lys Gly Ala Ser Gln Asn Asp Val Gly Tyr Gly Ala Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Arg Ser Gln Leu Gln Ala Ala Val Thr Ser Leu Lys Asn Asn Gly 
                85                  90                  95      


Ile Gln Val Tyr Gly Asp Val Val Met Asn His Lys Gly Gly Ala Asp 
            100                 105                 110         


Ala Thr Glu Met Val Arg Ala Val Glu Val Asn Pro Asn Asn Arg Asn 
        115                 120                 125             


Gln Glu Val Ser Gly Glu Tyr Thr Ile Glu Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr His Ser Asn Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Val Asp Trp Asp Gln Ser Arg Lys Leu Asn Asn Arg 
                165                 170                 175     


Ile Tyr Lys Phe Arg Gly Asp Gly Lys Gly Trp Asp Trp Glu Val Asp 
            180                 185                 190         


Thr Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Ile Asp Met 
        195                 200                 205             


Asp His Pro Glu Val Val Asn Glu Leu Arg Asn Trp Gly Val Trp Tyr 
    210                 215                 220                 


Thr Asn Thr Leu Gly Leu Asp Gly Phe Arg Ile Asp Ala Val Lys His 
225                 230                 235                 240 


Ile Lys Tyr Ser Phe Thr Arg Asp Trp Ile Asn His Val Arg Ser Ala 
                245                 250                 255     


Thr Gly Lys Asn Met Phe Ala Val Ala Glu Phe Trp Lys Asn Asp Leu 
            260                 265                 270         


Gly Ala Ile Glu Asn Tyr Leu Gln Lys Thr Asn Trp Asn His Ser Val 
        275                 280                 285             


Phe Asp Val Pro Leu His Tyr Asn Leu Tyr Asn Ala Ser Lys Ser Gly 
    290                 295                 300                 


Gly Asn Tyr Asp Met Arg Asn Ile Phe Asn Gly Thr Val Val Gln Arg 
305                 310                 315                 320 


His Pro Ser His Ala Val Thr Phe Val Asp Asn His Asp Ser Gln Pro 
                325                 330                 335     


Glu Glu Ala Leu Glu Ser Phe Val Glu Glu Trp Phe Lys Pro Leu Ala 
            340                 345                 350         


Tyr Ala Leu Thr Leu Thr Arg Glu Gln Gly Tyr Pro Ser Val Phe Tyr 
        355                 360                 365             


Gly Asp Tyr Tyr Gly Ile Pro Thr His Gly Val Pro Ala Met Arg Ser 
    370                 375                 380                 


Lys Ile Asp Pro Ile Leu Glu Ala Arg Gln Lys Tyr Ala Tyr Gly Lys 
385                 390                 395                 400 


Gln Asn Asp Tyr Leu Asp His His Asn Ile Ile Gly Trp Thr Arg Glu 
                405                 410                 415     


Gly Asn Thr Ala His Pro Asn Ser Gly Leu Ala Thr Ile Met Ser Asp 
            420                 425                 430         


Gly Ala Gly Gly Ser Lys Trp Met Phe Val Gly Arg Asn Lys Ala Gly 
        435                 440                 445             


Gln Val Trp Ser Asp Ile Thr Gly Asn Arg Thr Gly Thr Val Thr Ile 
    450                 455                 460                 


Asn Ala Asp Gly Trp Gly Asn Phe Ser Val Asn Gly Gly Ser Val Ser 
465                 470                 475                 480 


Ile Trp Val Asn Lys 
                485 


<210>  198
<211>  491
<212>  PRT
<213>  Artifiical Sequence

<400>  198

Ala Ala Thr Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr Val Pro 
1               5                   10                  15      


Asn Asp Gly Gln Gln Trp Asn Arg Leu Arg Thr Asp Ala Pro Tyr Leu 
            20                  25                  30          


Ser Ser Val Gly Ile Thr Ala Val Trp Thr Pro Pro Ala Tyr Lys Gly 
        35                  40                  45              


Thr Ser Gln Ala Asp Val Gly Tyr Gly Pro Tyr Asp Leu Tyr Asp Leu 
    50                  55                  60                  


Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly Thr Lys 
65                  70                  75                  80  


Gly Glu Leu Lys Ser Ala Val Asn Thr Leu His Ser Asn Gly Ile Gln 
                85                  90                  95      


Val Tyr Gly Asp Val Val Met Asn His Lys Ala Gly Ala Asp Gly Thr 
            100                 105                 110         


Glu Phe Val Asp Ala Val Glu Val Asp Pro Ser Asn Arg Asn Gln Glu 
        115                 120                 125             


Thr Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp Phe Pro 
    130                 135                 140                 


Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr His Phe 
145                 150                 155                 160 


Asp Gly Thr Asp Trp Asp Glu Ser Arg Lys Leu Asn Arg Ile Tyr Lys 
                165                 170                 175     


Phe Arg Ser Thr Gly Lys Ala Trp Asp Trp Glu Val Asp Thr Glu Asn 
            180                 185                 190         


Gly Asn Tyr Asp Tyr Leu Met Phe Ala Asp Leu Asp Met Asp His Pro 
        195                 200                 205             


Ile Asp Tyr Asp His Pro Asp Val Val Asn Glu Met Lys Lys Trp Gly 
    210                 215                 220                 


Val Trp Tyr Ala Asn Glu Val Gly Leu Asp Gly Tyr Arg Leu Asp Ala 
225                 230                 235                 240 


Val Lys His Ile Lys Phe Ser Phe Leu Lys Asp Trp Val Asp Asn Ala 
                245                 250                 255     


Arg Ala Ala Thr Gly Lys Glu Met Phe Thr Val Gly Glu Tyr Trp Gln 
            260                 265                 270         


Asn Asp Leu Gly Ala Leu Asn Asn Tyr Leu Ala Lys Val Asn Tyr Asn 
        275                 280                 285             


Gln Ser Leu Phe Asp Ala Pro Leu His Tyr Asn Phe Tyr Ala Ala Ser 
    290                 295                 300                 


Thr Gly Gly Gly Tyr Tyr Asp Met Arg Asn Ile Leu Asn Asn Thr Leu 
305                 310                 315                 320 


Val Ala Ser Asn Pro Thr Lys Ala Val Thr Leu Val Glu Asn His Asp 
                325                 330                 335     


Thr Gln Pro Gly Gln Ser Leu Glu Ser Thr Val Gln Pro Trp Phe Lys 
            340                 345                 350         


Pro Leu Ala Tyr Ala Phe Ile Leu Thr Arg Ser Gly Gly Tyr Pro Ser 
        355                 360                 365             


Val Phe Tyr Gly Asp Met Tyr Gly Thr Lys Gly Thr Thr Thr Arg Glu 
    370                 375                 380                 


Ile Pro Ala Leu Lys Ser Lys Ile Glu Pro Leu Leu Lys Ala Arg Lys 
385                 390                 395                 400 


Asp Tyr Ala Tyr Gly Thr Gln Arg Asp Tyr Ile Asp Asn Pro Asp Val 
                405                 410                 415     


Ile Gly Trp Thr Arg Glu Gly Asp Ser Thr Lys Ala Lys Ser Gly Leu 
            420                 425                 430         


Ala Thr Val Ile Thr Asp Gly Pro Gly Gly Ser Lys Arg Met Tyr Val 
        435                 440                 445             


Gly Thr Ser Asn Ala Gly Glu Ile Trp Tyr Asp Leu Thr Gly Asn Arg 
    450                 455                 460                 


Thr Asp Lys Ile Thr Ile Gly Ser Asp Gly Tyr Ala Thr Phe Pro Val 
465                 470                 475                 480 


Asn Gly Gly Ser Val Ser Val Trp Val Gln Gln 
                485                 490     


<210>  199
<211>  491
<212>  PRT
<213>  Artifical Sequence

<400>  199

Ala Ala Thr Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr Val Pro 
1               5                   10                  15      


Asn Asp Gly Gln Gln Trp Asn Arg Leu Arg Thr Asp Ala Pro Tyr Leu 
            20                  25                  30          


Ser Ser Val Gly Ile Thr Ala Val Trp Thr Pro Pro Ala Tyr Lys Gly 
        35                  40                  45              


Thr Ser Gln Ala Asp Val Gly Tyr Gly Pro Tyr Asp Leu Tyr Asp Leu 
    50                  55                  60                  


Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly Thr Lys 
65                  70                  75                  80  


Gly Glu Leu Lys Ser Ala Val Asn Thr Leu His Ser Asn Gly Ile Gln 
                85                  90                  95      


Val Tyr Gly Asp Val Val Met Asn His Lys Ala Gly Ala Asp Gly Thr 
            100                 105                 110         


Glu Phe Val Asp Ala Val Glu Val Asp Pro Ser Asn Arg Asn Gln Glu 
        115                 120                 125             


Thr Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp Phe Pro 
    130                 135                 140                 


Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr His Phe 
145                 150                 155                 160 


Asp Gly Thr Asp Trp Asp Glu Ser Arg Lys Leu Asn Arg Ile Tyr Lys 
                165                 170                 175     


Phe Arg Ser Thr Gly Lys Ala Trp Asp Trp Glu Val Asp Thr Glu Asn 
            180                 185                 190         


Gly Asn Tyr Asp Tyr Leu Met Phe Ala Asp Leu Asp Met Asp His Pro 
        195                 200                 205             


Tyr Asp Tyr Asp His Pro Asp Val Val Asn Glu Met Lys Lys Trp Gly 
    210                 215                 220                 


Val Trp Tyr Ala Asn Glu Val Gly Leu Asp Gly Tyr Arg Leu Asp Ala 
225                 230                 235                 240 


Val Lys His Ile Lys Phe Ser Phe Leu Lys Asp Trp Val Asp Asn Ala 
                245                 250                 255     


Arg Ala Ala Thr Gly Lys Glu Met Phe Thr Val Gly Glu Tyr Trp Gln 
            260                 265                 270         


Asn Asp Leu Gly Ala Leu Asn Asn Tyr Leu Ala Lys Val Asn Tyr Asn 
        275                 280                 285             


Gln Ser Leu Phe Asp Ala Pro Leu His Tyr Asn Phe Tyr Ala Ala Ser 
    290                 295                 300                 


Thr Gly Gly Gly Tyr Tyr Asp Met Arg Asn Ile Leu Asn Asn Thr Leu 
305                 310                 315                 320 


Val Ala Ser Asn Pro Thr Lys Ala Val Thr Leu Val Glu Asn His Asp 
                325                 330                 335     


Thr Gln Pro Gly Gln Ser Leu Glu Ser Thr Val Gln Pro Trp Phe Lys 
            340                 345                 350         


Pro Leu Ala Tyr Ala Phe Ile Leu Thr Arg Ser Gly Gly Tyr Pro Ser 
        355                 360                 365             


Val Phe Tyr Gly Asp Met Tyr Gly Thr Lys Gly Thr Thr Thr Arg Glu 
    370                 375                 380                 


Ile Pro Ala Leu Lys Ser Lys Ile Glu Pro Leu Leu Lys Ala Arg Lys 
385                 390                 395                 400 


Asp Tyr Ala Tyr Gly Thr Gln Arg Asp Tyr Ile Asp Asn Pro Asp Val 
                405                 410                 415     


Ile Gly Trp Thr Arg Glu Gly Asp Ser Thr Lys Ala Lys Ser Gly Leu 
            420                 425                 430         


Ala Thr Val Ile Thr Asp Gly Pro Gly Gly Ser Lys Arg Met Tyr Val 
        435                 440                 445             


Gly Thr Ser Asn Ala Gly Glu Ile Trp Tyr Asp Leu Thr Gly Asn Asn 
    450                 455                 460                 


Ser Thr Lys Ile Thr Ile Gly Ser Asp Gly Tyr Ala Thr Phe Pro Val 
465                 470                 475                 480 


Asn Lys Gly Ser Val Ser Val Trp Val Gln Gln 
                485                 490     


<210>  200
<211>  491
<212>  PRT
<213>  Artifical Sequence

<400>  200

Ala Ala Thr Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr Val Pro 
1               5                   10                  15      


Asn Asp Gly Gln Gln Trp Asn Arg Leu Arg Thr Asp Ala Pro Tyr Leu 
            20                  25                  30          


Ser Ser Val Gly Ile Asn Ala Val Trp Thr Pro Pro Ala Tyr Lys Gly 
        35                  40                  45              


Thr Ser Gln Ala Asp Val Gly Tyr Gly Pro Tyr Asp Leu Tyr Asp Leu 
    50                  55                  60                  


Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly Thr Lys 
65                  70                  75                  80  


Gly Glu Leu Lys Ser Ala Val Asn Thr Leu His Ser Asn Gly Ile Gln 
                85                  90                  95      


Val Tyr Gly Asp Val Val Met Asn His Lys Ala Gly Ala Asp Gly Thr 
            100                 105                 110         


Glu Phe Val Asp Ala Val Glu Val Asp Pro Ser Asn Arg Asn Gln Glu 
        115                 120                 125             


Thr Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp Phe Pro 
    130                 135                 140                 


Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr His Phe 
145                 150                 155                 160 


Asp Gly Thr Asp Trp Asp Glu Ser Arg Lys Leu Asn Arg Ile Tyr Lys 
                165                 170                 175     


Phe Arg Ser Thr Gly Lys Ala Trp Asp Trp Glu Val Asp Thr Glu Asn 
            180                 185                 190         


Gly Asn Tyr Asp Tyr Leu Met Phe Ala Asp Leu Asp Met Asp His Pro 
        195                 200                 205             


Tyr Asp Tyr Asp His Pro Asp Val Val Asn Glu Met Lys Lys Trp Gly 
    210                 215                 220                 


Val Trp Tyr Ala Asn Glu Val Gly Leu Asp Gly Tyr Arg Leu Asp Ala 
225                 230                 235                 240 


Val Lys His Ile Lys Phe Ser Phe Leu Lys Asp Trp Val Asp Asn Ala 
                245                 250                 255     


Arg Ala Ala Thr Gly Lys Glu Met Phe Thr Val Gly Glu Tyr Trp Gln 
            260                 265                 270         


Asn Asp Leu Gly Ala Leu Asn Asn Tyr Leu Ala Lys Val Asn Tyr Asn 
        275                 280                 285             


Gln Ser Leu Phe Asp Ala Pro Leu His Tyr Asn Phe Tyr Ala Ala Ser 
    290                 295                 300                 


Thr Gly Gly Gly Tyr Tyr Asp Met Arg Asn Ile Leu Asn Asn Thr Leu 
305                 310                 315                 320 


Val Ala Ser Asn Pro Thr Lys Ala Val Thr Leu Val Glu Asn His Asp 
                325                 330                 335     


Thr Gln Pro Gly Gln Ser Leu Glu Ser Thr Val Gln Pro Trp Phe Lys 
            340                 345                 350         


Pro Leu Ala Tyr Ala Phe Ile Leu Thr Arg Ser Gly Gly Tyr Pro Ser 
        355                 360                 365             


Val Phe Tyr Gly Asp Met Tyr Gly Thr Lys Gly Thr Thr Thr Arg Glu 
    370                 375                 380                 


Ile Pro Ala Leu Lys Ser Lys Ile Glu Pro Leu Leu Lys Ala Arg Lys 
385                 390                 395                 400 


Asp Tyr Ala Tyr Gly Thr Gln Arg Asp Tyr Ile Asp Asn Pro Asp Val 
                405                 410                 415     


Ile Gly Trp Thr Arg Glu Gly Asp Ser Thr Lys Ala Lys Ser Gly Leu 
            420                 425                 430         


Ala Thr Val Ile Thr Asp Gly Pro Gly Gly Ser Lys Arg Met Tyr Val 
        435                 440                 445             


Gly Thr Ser Asn Ala Gly Glu Ile Trp Tyr Asp Leu Thr Gly Asn Arg 
    450                 455                 460                 


Thr Asp Lys Ile Thr Ile Gly Ser Asp Gly Tyr Ala Thr Phe Pro Val 
465                 470                 475                 480 


Asn Lys Glu Ser Val Ser Val Trp Val Gln Gln 
                485                 490     


<210>  201
<211>  490
<212>  PRT
<213>  Artifical Sequence

<400>  201

His His Asn Gly Thr Asn Gly Thr Met Met Gln Tyr Phe Glu Trp His 
1               5                   10                  15      


Leu Pro Asn Asp Gly Gln His Trp Asn Arg Leu Arg Asn Asp Ala Ala 
            20                  25                  30          


Asn Leu Lys Asn Leu Gly Ile Thr Ala Val Trp Ile Pro Pro Ala Trp 
        35                  40                  45              


Lys Gly Thr Ser Gln Asn Asp Val Gly Tyr Gly Ala Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Ile Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Arg Ser Gln Leu Gln Ser Ala Ile Ala Ser Leu Gln Asn Asn Gly 
                85                  90                  95      


Ile Gln Val Tyr Gly Asp Val Val Met Asn His Lys Ala Gly Ala Asp 
            100                 105                 110         


Gly Thr Glu Phe Val Asp Ala Val Glu Val Asp Pro Ser Asn Arg Asn 
        115                 120                 125             


Gln Glu Thr Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Glu Ser Arg Lys Leu Asn Arg Ile 
                165                 170                 175     


Tyr Lys Phe Arg Ser Thr Gly Lys Ala Trp Asp Trp Glu Val Asp Thr 
            180                 185                 190         


Glu Asn Gly Asn Tyr Asp Tyr Leu Met Phe Ala Asp Leu Asp Met Asp 
        195                 200                 205             


His Pro Val Asp Met Asp His Pro Glu Val Ile Asn Glu Leu Arg Arg 
    210                 215                 220                 


Trp Gly Val Trp Tyr Thr Asn Thr Leu Asn Leu Asp Gly Phe Arg Ile 
225                 230                 235                 240 


Asp Ala Val Lys His Ile Lys Tyr Ser Phe Thr Arg Asp Trp Leu Asn 
                245                 250                 255     


His Val Arg Ser Thr Gly Lys Asn Asn Met Phe Ala Val Ala Glu Phe 
            260                 265                 270         


Trp Lys Asn Asp Leu Gly Ala Ile Glu Asn Tyr Leu His Lys Thr Asn 
        275                 280                 285             


Trp Asn His Ser Val Phe Asp Val Pro Leu His Tyr Asn Leu Tyr Asn 
    290                 295                 300                 


Ala Ser Lys Ser Gly Gly Asn Tyr Asp Met Arg Gln Ile Leu Asn Gly 
305                 310                 315                 320 


Thr Val Val Ser Lys His Pro Ile His Ala Val Thr Phe Val Asp Asn 
                325                 330                 335     


His Asp Ser Gln Pro Ala Glu Ala Leu Glu Ser Phe Val Glu Ala Trp 
            340                 345                 350         


Phe Lys Pro Leu Ala Tyr Ala Leu Ile Leu Thr Arg Glu Gln Gly Tyr 
        355                 360                 365             


Pro Ser Val Phe Tyr Gly Asp Tyr Tyr Gly Ile Pro Thr His Gly Val 
    370                 375                 380                 


Ala Ala Met Lys Gly Lys Ile Asp Pro Ile Leu Glu Ala Arg Gln Lys 
385                 390                 395                 400 


Tyr Ala Tyr Gly Thr Gln His Asp Tyr Leu Asp His His Asn Ile Ile 
                405                 410                 415     


Gly Trp Thr Arg Glu Gly Asn Ser Ala His Pro Asn Ser Gly Leu Ala 
            420                 425                 430         


Thr Ile Met Ser Asp Gly Pro Gly Gly Ser Lys Trp Met Tyr Val Gly 
        435                 440                 445             


Arg His Lys Ala Gly Gln Val Trp Arg Asp Ile Thr Gly Asn Arg Thr 
    450                 455                 460                 


Gly Thr Val Thr Ile Asn Ala Asp Gly Trp Gly Asn Phe Ser Val Asn 
465                 470                 475                 480 


Gly Gly Ser Val Ser Ile Trp Val Asn Lys 
                485                 490 


