                         SEQUENCE LISTING

<110>  RELIANCE INDUSTRIES LIMITED
       RELIANCE INDUSTRIES, LIMITED
 
<120>  GENETICALLY MODIFIED MICROORGANISM, METHOD(S) AND APPLICATION(S) 
       THEREOF

<130>  IP48923/SM/rr

<140>  202121012887
<141>  2021-06-24

<160>  23    

<170>  PatentIn version 3.5

<210>  1
<211>  369
<212>  DNA
<213>  Cyanobacteria


<220>
<221>  gene
<222>  (1)..(369)
<223>  Wild Type Cyanoglobin gene

<400>  1
tcggtttaaa acatcatttc gatgggatag agccccgaca atcgccccaa cttcgtcaat       60

taaattttgt tcgataccta actctttgag agtattgatc aaattttctg cgatcgcatc      120

aaaatgaaca tccgttaaac ccatattatc tactaaatgt ttatgggatt ctcgcatatc      180

tctaccagaa aaagtatcag gacctccaaa agcataagtc ataaaagcct tttgatgagc      240

tttttgtttc ttcatatccg tattggcaaa gaaataatta actcggtcat cctttaacac      300

cttatcatag aacttatcga ctgcaatatc tacagcttct ttaccgccta atttttcgta      360

caaactact                                                              369


<210>  2
<211>  124
<212>  PRT
<213>  Cyanobacteria


<220>
<221>  NP_BIND
<222>  (1)..(124)
<223>  Wild type Cyanoglobin protein

<400>  2

Met Ser Ser Leu Tyr Glu Lys Leu Gly Gly Lys Glu Ala Val Asp Ile 
1               5                   10                  15      


Ala Val Asp Lys Phe Tyr Asp Lys Val Leu Lys Asp Asp Arg Val Asn 
            20                  25                  30          


Tyr Phe Phe Ala Asn Thr Asp Met Lys Lys Gln Lys Ala His Gln Lys 
        35                  40                  45              


Ala Phe Met Thr Tyr Ala Phe Gly Gly Pro Asp Thr Phe Ser Gly Arg 
    50                  55                  60                  


Asp Met Arg Glu Ser His Lys His Leu Val Asp Asn Met Gly Leu Thr 
65                  70                  75                  80  


Asp Val His Phe Asp Ala Ile Ala Glu Asn Leu Ile Asn Thr Leu Lys 
                85                  90                  95      


Glu Leu Gly Ile Glu Gln Asn Leu Ile Asp Glu Val Gly Ala Ile Val 
            100                 105                 110         


Gly Ala Leu Ser His Arg Asn Asp Val Leu Asn Arg 
        115                 120                 


<210>  3
<211>  1227
<212>  DNA
<213>  Escherichia coli


<220>
<221>  gene
<222>  (1)..(1227)
<223>  Wild type HemA gene

<400>  3
atggattata acttggcatt agatactgca ttgaaccgtt tacacactga agggcgttat       60

cgcacattca tcgacatcga acgccgcaag ggcgctttcc cgaaggctat gtggcgtaag      120

ccggatggat ctgagaaaga gattacggtc tggtgcggca acgattactt ggggatggga      180

cagcacccgg tagttcttgg agcaatgcac gaggcacttg actcgacagg tgcggggtct      240

gggggtaccc gcaatatctc cggcacaaca ttatatcata aacgtctgga agcagaactg      300

gcagatttac atgggaagga agcagcgtta gtctttagct cagcatacat cgcaaacgac      360

gctacgttgt ctacgttgcc tcaacttatt cccggacttg tcattgtctc cgacaagctg      420

aatcatgcta gtatgatcga agggatccgc cgctcgggaa ctgaaaaaca catcttcaaa      480

cataatgacc tggatgattt gcgccgcatt cttaccagca ttgggaagga tcgcccaatt      540

ttggttgcgt tcgagagtgt atatagtatg gacggtgact tcggacgcat tgaggaaatt      600

tgcgacatcg cagatgaatt tggagcatta aagtacattg atgaagtaca cgcggtggga      660

atgtatggac cgcgcggtgg tggtgttgct gaacgtgacg gactgatgga ccgcatcgac      720

attattaacg gcacgctggg taaagcctac ggagttttcg gagggtatat tgccgcctct      780

tctaagatgt gtgatgcggt acgctcatat gctccgggat ttattttctc cacttctctg      840

ccgccggtgg tcgccgctgg ggccgctgct tccgttcgcc acctgaaggg tgacgtagaa      900

ttacgtgaga agcaccagac acaggcgcgt attttaaaga tgcgtttgaa gggattgggt      960

ctgcctatta ttgatcacgg gtctcatatc gtccctgtac acgtcggcga tccggtccac     1020

tgcaagatga tttctgacat gctgctggaa cacttcggca tttatgtaca gcctatcaac     1080

ttcccgacag ttcctcgtgg aaccgagcgc ttgcgtttca ctccttcacc tgttcacgac     1140

tctgggatga tcgatcactt agttaaagca atggacgtct tatggcagca ctgtgctctt     1200

aatcgtgccg aggtagtggc tctcgag                                         1227


<210>  4
<211>  409
<212>  PRT
<213>  Escherichia coli


<220>
<221>  PEPTIDE
<222>  (2)..(409)
<223>  Wild type HemA protein

<400>  4

Met Asp Tyr Asn Leu Ala Leu Asp Thr Ala Leu Asn Arg Leu His Thr 
1               5                   10                  15      


Glu Gly Arg Tyr Arg Thr Phe Ile Asp Ile Glu Arg Arg Lys Gly Ala 
            20                  25                  30          


Phe Pro Lys Ala Met Trp Arg Lys Pro Asp Gly Ser Glu Lys Glu Ile 
        35                  40                  45              


Thr Val Trp Cys Gly Asn Asp Tyr Leu Gly Met Gly Gln His Pro Val 
    50                  55                  60                  


Val Leu Gly Ala Met His Glu Ala Leu Asp Ser Thr Gly Ala Gly Ser 
65                  70                  75                  80  


Gly Gly Thr Arg Asn Ile Ser Gly Thr Thr Leu Tyr His Lys Arg Leu 
                85                  90                  95      


Glu Ala Glu Leu Ala Asp Leu His Gly Lys Glu Ala Ala Leu Val Phe 
            100                 105                 110         


Ser Ser Ala Tyr Ile Ala Asn Asp Ala Thr Leu Ser Thr Leu Pro Gln 
        115                 120                 125             


Leu Ile Pro Gly Leu Val Ile Val Ser Asp Lys Leu Asn His Ala Ser 
    130                 135                 140                 


Met Ile Glu Gly Ile Arg Arg Ser Gly Thr Glu Lys His Ile Phe Lys 
145                 150                 155                 160 


His Asn Asp Leu Asp Asp Leu Arg Arg Ile Leu Thr Ser Ile Gly Lys 
                165                 170                 175     


Asp Arg Pro Ile Leu Val Ala Phe Glu Ser Val Tyr Ser Met Asp Gly 
            180                 185                 190         


Asp Phe Gly Arg Ile Glu Glu Ile Cys Asp Ile Ala Asp Glu Phe Gly 
        195                 200                 205             


Ala Leu Lys Tyr Ile Asp Glu Val His Ala Val Gly Met Tyr Gly Pro 
    210                 215                 220                 


Arg Gly Gly Gly Val Ala Glu Arg Asp Gly Leu Met Asp Arg Ile Asp 
225                 230                 235                 240 


Ile Ile Asn Gly Thr Leu Gly Lys Ala Tyr Gly Val Phe Gly Gly Tyr 
                245                 250                 255     


Ile Ala Ala Ser Ser Lys Met Cys Asp Ala Val Arg Ser Tyr Ala Pro 
            260                 265                 270         


Gly Phe Ile Phe Ser Thr Ser Leu Pro Pro Val Val Ala Ala Gly Ala 
        275                 280                 285             


Ala Ala Ser Val Arg His Leu Lys Gly Asp Val Glu Leu Arg Glu Lys 
    290                 295                 300                 


His Gln Thr Gln Ala Arg Ile Leu Lys Met Arg Leu Lys Gly Leu Gly 
305                 310                 315                 320 


Leu Pro Ile Ile Asp His Gly Ser His Ile Val Pro Val His Val Gly 
                325                 330                 335     


Asp Pro Val His Cys Lys Met Ile Ser Asp Met Leu Leu Glu His Phe 
            340                 345                 350         


Gly Ile Tyr Val Gln Pro Ile Asn Phe Pro Thr Val Pro Arg Gly Thr 
        355                 360                 365             


Glu Arg Leu Arg Phe Thr Pro Ser Pro Val His Asp Ser Gly Met Ile 
    370                 375                 380                 


Asp His Leu Val Lys Ala Met Asp Val Leu Trp Gln His Cys Ala Leu 
385                 390                 395                 400 


Asn Arg Ala Glu Val Val Ala Leu Glu 
                405                 


<210>  5
<211>  1224
<212>  DNA
<213>  Synthetic


<220>
<221>  gene
<222>  (1)..(1224)
<223>  Synthetic HemA (Codon optimized for E. coli)

<400>  5
atggattata acttggcatt agatactgca ttgaaccgtt tacacactga agggcgttat       60

cgcacattca tcgacatcga acgccgcaag ggcgctttcc cgaaggctat gtggcgtaag      120

ccggatggat ctgagaaaga gattacggtc tggtgcggca acgattactt ggggatggga      180

cagcacccgg tagttcttgg agcaatgcac gaggcacttg actcgacagg tgcggggtct      240

gggggtaccc gcaatatctc cggcacaaca ttatatcata aacgtctgga agcagaactg      300

gcagatttac atgggaagga agcagcgtta gtctttagct cagcatacat cgcaaacgac      360

gctacgttgt ctacgttgcc tcaacttatt cccggacttg tcattgtctc cgacaagctg      420

aatcatgcta gtatgatcga agggatccgc cgctcgggaa ctgaaaaaca catcttcaaa      480

cataatgacc tggatgattt gcgccgcatt cttaccagca ttgggaagga tcgcccaatt      540

ttggttgcgt tcgagagtgt atatagtatg gacggtgact tcggacgcat tgaggaaatt      600

tgcgacatcg cagatgaatt tggagcatta aagtacattg atgaagtaca cgcggtggga      660

atgtatggac cgcgcggtgg tggtgttgct gaacgtgacg gactgatgga ccgcatcgac      720

attattaacg gcacgctggg taaagcctac ggagttttcg gagggtatat tgccgcctct      780

tctaagatgt gtgatgcggt acgctcatat gctccgggat ttattttctc cacttctctg      840

ccgccggtgg tcgccgctgg ggccgctgct tccgttcgcc acctgaaggg tgacgtagaa      900

ttacgtgaga agcaccagac acaggcgcgt attttaaaga tgcgtttgaa gggattgggt      960

ctgcctatta ttgatcacgg gtctcatatc gtccctgtac acgtcggcga tccggtccac     1020

tgcaagatga tttctgacat gctgctggaa cacttcggca tttatgtaca gcctatcaac     1080

ttcccgacag ttcctcgtgg aaccgagcgc ttgcgtttca ctccttcacc tgttcacgac     1140

tctgggatga tcgatcactt agttaaagca atggacgtct tatggcagca ctgtgctctt     1200

aatcgtgccg aggtagtggc ttga                                            1224


<210>  6
<211>  407
<212>  PRT
<213>  Synthetic


<220>
<221>  PEPTIDE
<222>  (1)..(407)
<223>  Synthetic HemA protein (Codon optimized for E. coli)

<400>  6

Met Asp Tyr Asn Leu Ala Leu Asp Thr Ala Leu Asn Arg Leu His Thr 
1               5                   10                  15      


Glu Gly Arg Tyr Arg Thr Phe Ile Asp Ile Glu Arg Arg Lys Gly Ala 
            20                  25                  30          


Phe Pro Lys Ala Met Trp Arg Lys Pro Asp Gly Ser Glu Lys Glu Ile 
        35                  40                  45              


Thr Val Trp Cys Gly Asn Asp Tyr Leu Gly Met Gly Gln His Pro Val 
    50                  55                  60                  


Val Leu Gly Ala Met His Glu Ala Leu Asp Ser Thr Gly Ala Gly Ser 
65                  70                  75                  80  


Gly Gly Thr Arg Asn Ile Ser Gly Thr Thr Leu Tyr His Lys Arg Leu 
                85                  90                  95      


Glu Ala Glu Leu Ala Asp Leu His Gly Lys Glu Ala Ala Leu Val Phe 
            100                 105                 110         


Ser Ser Ala Tyr Ile Ala Asn Asp Ala Thr Leu Ser Thr Leu Pro Gln 
        115                 120                 125             


Leu Ile Pro Gly Leu Val Ile Val Ser Asp Lys Leu Asn His Ala Ser 
    130                 135                 140                 


Met Ile Glu Gly Ile Arg Arg Ser Gly Thr Glu Lys His Ile Phe Lys 
145                 150                 155                 160 


His Asn Asp Leu Asp Asp Leu Arg Arg Ile Leu Thr Ser Ile Gly Lys 
                165                 170                 175     


Asp Arg Pro Ile Leu Val Ala Phe Glu Ser Val Tyr Ser Met Asp Gly 
            180                 185                 190         


Asp Phe Gly Arg Ile Glu Glu Ile Cys Asp Ile Ala Asp Glu Phe Gly 
        195                 200                 205             


Ala Leu Lys Tyr Ile Asp Glu Val His Ala Val Gly Met Tyr Gly Pro 
    210                 215                 220                 


Arg Gly Gly Gly Val Ala Glu Arg Asp Gly Leu Met Asp Arg Ile Asp 
225                 230                 235                 240 


Ile Ile Asn Gly Thr Leu Gly Lys Ala Tyr Gly Val Phe Gly Gly Tyr 
                245                 250                 255     


Ile Ala Ala Ser Ser Lys Met Cys Asp Ala Val Arg Ser Tyr Ala Pro 
            260                 265                 270         


Gly Phe Ile Phe Ser Thr Ser Leu Pro Pro Val Val Ala Ala Gly Ala 
        275                 280                 285             


Ala Ala Ser Val Arg His Leu Lys Gly Asp Val Glu Leu Arg Glu Lys 
    290                 295                 300                 


His Gln Thr Gln Ala Arg Ile Leu Lys Met Arg Leu Lys Gly Leu Gly 
305                 310                 315                 320 


Leu Pro Ile Ile Asp His Gly Ser His Ile Val Pro Val His Val Gly 
                325                 330                 335     


Asp Pro Val His Cys Lys Met Ile Ser Asp Met Leu Leu Glu His Phe 
            340                 345                 350         


Gly Ile Tyr Val Gln Pro Ile Asn Phe Pro Thr Val Pro Arg Gly Thr 
        355                 360                 365             


Glu Arg Leu Arg Phe Thr Pro Ser Pro Val His Asp Ser Gly Met Ile 
    370                 375                 380                 


Asp His Leu Val Lys Ala Met Asp Val Leu Trp Gln His Cys Ala Leu 
385                 390                 395                 400 


Asn Arg Ala Glu Val Val Ala 
                405         


<210>  7
<211>  1224
<212>  DNA
<213>  Synthetic


<220>
<221>  gene
<222>  (1)..(1224)
<223>  Synthetic HemA (Codon optimized for Cyanobacteria)

<400>  7
atggattata atttagcttt agatactgct ttaaatagat tacatactga aggtagatat       60

agaactttta ttgatattga aagaagaaaa ggtgcttttc ctaaagctat gtggagaaaa      120

cctgatggtt ctgaaaaaga aattactgtt tggtgtggta atgattattt aggtatgggt      180

caacatcctg ttgttttagg tgctatgcat gaagctttag attctactgg tgctggttct      240

ggtggtacta gaaatatttc tggtactact ttatatcata aaagattaga agctgaatta      300

gctgatttac atggtaaaga agctgcttta gttttttctt ctgcttatat tgctaatgat      360

gctactttat ctactttacc tcaattaatt cctggtttag ttattgtttc tgataaatta      420

aatcatgctt ctatgattga aggtattaga agatctggta ctgaaaaaca tatttttaaa      480

cataatgatt tagatgattt aagaagaatt ttaacttcta ttggtaaaga tagacctatt      540

ttagttgctt ttgaatctgt ttattctatg gatggtgatt ttggtagaat tgaagaaatt      600

tgtgatattg ctgatgaatt tggtgcttta aaatatattg atgaagttca tgctgttggt      660

atgtatggtc ctagaggtgg tggtgttgct gaaagagatg gtttaatgga tagaattgat      720

attattaatg gtactttagg taaagcttat ggtgtttttg gtggttatat tgctgcttct      780

tctaaaatgt gtgatgctgt tagatcttat gctcctggtt ttattttttc tacttcttta      840

cctcctgttg ttgctgctgg tgctgctgct tctgttagac atttaaaagg tgatgttgaa      900

ttaagagaaa aacatcaaac tcaagctaga attttaaaaa tgagattaaa aggtttaggt      960

ttacctatta ttgatcatgg ttctcatatt gttcctgttc atgttggtga tcctgttcat     1020

tgtaaaatga tttctgatat gttattagaa cattttggta tttatgttca acctattaat     1080

tttcctactg ttcctagagg tactgaaaga ttaagattta ctccttctcc tgttcatgat     1140

tctggtatga ttgatcattt agttaaagct atggatgttt tatggcaaca ttgtgcttta     1200

aatagagctg aagttgttgc ttga                                            1224


<210>  8
<211>  407
<212>  PRT
<213>  Synthetic


<220>
<221>  PEPTIDE
<222>  (1)..(407)
<223>  Synthetic HemA protein (Codon optimized for Cyanobacteria)

<400>  8

Met Asp Tyr Asn Leu Ala Leu Asp Thr Ala Leu Asn Arg Leu His Thr 
1               5                   10                  15      


Glu Gly Arg Tyr Arg Thr Phe Ile Asp Ile Glu Arg Arg Lys Gly Ala 
            20                  25                  30          


Phe Pro Lys Ala Met Trp Arg Lys Pro Asp Gly Ser Glu Lys Glu Ile 
        35                  40                  45              


Thr Val Trp Cys Gly Asn Asp Tyr Leu Gly Met Gly Gln His Pro Val 
    50                  55                  60                  


Val Leu Gly Ala Met His Glu Ala Leu Asp Ser Thr Gly Ala Gly Ser 
65                  70                  75                  80  


Gly Gly Thr Arg Asn Ile Ser Gly Thr Thr Leu Tyr His Lys Arg Leu 
                85                  90                  95      


Glu Ala Glu Leu Ala Asp Leu His Gly Lys Glu Ala Ala Leu Val Phe 
            100                 105                 110         


Ser Ser Ala Tyr Ile Ala Asn Asp Ala Thr Leu Ser Thr Leu Pro Gln 
        115                 120                 125             


Leu Ile Pro Gly Leu Val Ile Val Ser Asp Lys Leu Asn His Ala Ser 
    130                 135                 140                 


Met Ile Glu Gly Ile Arg Arg Ser Gly Thr Glu Lys His Ile Phe Lys 
145                 150                 155                 160 


His Asn Asp Leu Asp Asp Leu Arg Arg Ile Leu Thr Ser Ile Gly Lys 
                165                 170                 175     


Asp Arg Pro Ile Leu Val Ala Phe Glu Ser Val Tyr Ser Met Asp Gly 
            180                 185                 190         


Asp Phe Gly Arg Ile Glu Glu Ile Cys Asp Ile Ala Asp Glu Phe Gly 
        195                 200                 205             


Ala Leu Lys Tyr Ile Asp Glu Val His Ala Val Gly Met Tyr Gly Pro 
    210                 215                 220                 


Arg Gly Gly Gly Val Ala Glu Arg Asp Gly Leu Met Asp Arg Ile Asp 
225                 230                 235                 240 


Ile Ile Asn Gly Thr Leu Gly Lys Ala Tyr Gly Val Phe Gly Gly Tyr 
                245                 250                 255     


Ile Ala Ala Ser Ser Lys Met Cys Asp Ala Val Arg Ser Tyr Ala Pro 
            260                 265                 270         


Gly Phe Ile Phe Ser Thr Ser Leu Pro Pro Val Val Ala Ala Gly Ala 
        275                 280                 285             


Ala Ala Ser Val Arg His Leu Lys Gly Asp Val Glu Leu Arg Glu Lys 
    290                 295                 300                 


His Gln Thr Gln Ala Arg Ile Leu Lys Met Arg Leu Lys Gly Leu Gly 
305                 310                 315                 320 


Leu Pro Ile Ile Asp His Gly Ser His Ile Val Pro Val His Val Gly 
                325                 330                 335     


Asp Pro Val His Cys Lys Met Ile Ser Asp Met Leu Leu Glu His Phe 
            340                 345                 350         


Gly Ile Tyr Val Gln Pro Ile Asn Phe Pro Thr Val Pro Arg Gly Thr 
        355                 360                 365             


Glu Arg Leu Arg Phe Thr Pro Ser Pro Val His Asp Ser Gly Met Ile 
    370                 375                 380                 


Asp His Leu Val Lys Ala Met Asp Val Leu Trp Gln His Cys Ala Leu 
385                 390                 395                 400 


Asn Arg Ala Glu Val Val Ala 
                405         


<210>  9
<211>  1836
<212>  DNA
<213>  Synthetic


<220>
<221>  gene
<222>  (1)..(1836)
<223>  FeoB (Codon optimized for Cyanobacteria)

<400>  9
atgtcttgtc attctgctac cacgaaagtt ttaccaaatt ctcaaaagcg tattgccgta       60

attggacaac cgaatactgg aaaatcaacc ttttttaatc gtttaactgg gagtaatgct      120

tctgtaggca attggtctgg tataactgtg gatttactac aggcagaaat taatctgaat      180

aatgaagtgg tggaagtggt agatttaccc ggtatttatg attttaatgg cttttctgat      240

gatgaaaagg tggtgcagag gtttttggaa acttttcccc tcgatttagc tattattatt      300

atcaacgcta ctcaaattga tcgcacctta agattaatat tagagatgaa aaggttagga      360

ttaccttgcg tcgtaatgtt aaatatggca gatgaagcca aacgctatgg agtagaaata      420

aatcactatc aactgcaaga gattttaggg ataccttgtt tttcaattag tgccaaatat      480

ggtaaaggtt tttcccaagc tgttaggggc atagaaaagg cactatccac ccaagaggat      540

tctttcattc ttaaagatgt tcatgatttt ctctccacga atcctgtaac agagacagaa      600

attaactcga ttttggagaa aaccgtcaaa gtaccccctg aagaaattaa aacgattacg      660

gataaactcg atcgcatttt acttcatcct attttcggaa taccactttt ttttatttcc      720

atgttaggaa tattctttct aatttggtat ctcggtttac cctctcaaga cattatggga      780

aatatcaccg attggattag tgggcaaatt atcgagccaa ctattcaacc actgcccgaa      840

atattgcaaa attttctcct caatggagtt tggttaggtg tagcaactgt agcttctttt      900

gtacctttaa tcgttctctt tttctttgta atggcggcgg tagaagatag tggttatcta      960

gctcgatcag cttacctcat ggatgcttta atggaaaaat tagggctaga tggtagggct     1020

tttgtcatgc aaatgatggg atttggctgt aatgttcctg ctttaatggg tacaagagta     1080

attcgatcgc aacctatgcg ttggttatca atgttaatta taccttttgc cctttgttct     1140

gcaagactag cagtatttgt ttttattatt gccgctattt tccctcccaa tttaggaccg     1200

attattcttt tttctctcta tttactaagt tttattgcta gtttttttgt tgcttttgta     1260

tttagtaaaa ctaaagaatt tcaaagtcaa gaacctttta ttattgaact tcctccctat     1320

agattaccca ctttaagaca agtactatta aggggatggg gggaagtaaa agaatttttg     1380

cgaagggcaa ctaactttat tatcatcggg tgtgtagcag tatggttttt aacttatttt     1440

cctgaaaaca gcataggatt agagacatgg ggaggacaac taggaatttt attacaacct     1500

attatgcaac cgattggcat tgatccctat ttaactttat ctttaatttt tggctttatt     1560

gctaaagaaa ttgttgtggg ttcatttgcc acgatttatg gtttaagttc atcggcatta     1620

actcaacata ttgccctaac tataactcct gcggcggcag tttctttttg tatcttttgc     1680

ttattatata ctccttgttt atccaccgtt gccaccatta aagcagagtc caaatcgaca     1740

atttttactt tattttcttt gcttttttct ctagtttatg cttggatatg tgcttttatt     1800

ttctatcatc tggcactaac attatttcct atttaa                               1836


<210>  10
<211>  611
<212>  PRT
<213>  Synthetic


<220>
<221>  PEPTIDE
<222>  (1)..(611)
<223>  FeoB protein (Codon optimized for Cyanobacteria)

<400>  10

Met Ser Cys His Ser Ala Thr Thr Lys Val Leu Pro Asn Ser Gln Lys 
1               5                   10                  15      


Arg Ile Ala Val Ile Gly Gln Pro Asn Thr Gly Lys Ser Thr Phe Phe 
            20                  25                  30          


Asn Arg Leu Thr Gly Ser Asn Ala Ser Val Gly Asn Trp Ser Gly Ile 
        35                  40                  45              


Thr Val Asp Leu Leu Gln Ala Glu Ile Asn Leu Asn Asn Glu Val Val 
    50                  55                  60                  


Glu Val Val Asp Leu Pro Gly Ile Tyr Asp Phe Asn Gly Phe Ser Asp 
65                  70                  75                  80  


Asp Glu Lys Val Val Gln Arg Phe Leu Glu Thr Phe Pro Leu Asp Leu 
                85                  90                  95      


Ala Ile Ile Ile Ile Asn Ala Thr Gln Ile Asp Arg Thr Leu Arg Leu 
            100                 105                 110         


Ile Leu Glu Met Lys Arg Leu Gly Leu Pro Cys Val Val Met Leu Asn 
        115                 120                 125             


Met Ala Asp Glu Ala Lys Arg Tyr Gly Val Glu Ile Asn His Tyr Gln 
    130                 135                 140                 


Leu Gln Glu Ile Leu Gly Ile Pro Cys Phe Ser Ile Ser Ala Lys Tyr 
145                 150                 155                 160 


Gly Lys Gly Phe Ser Gln Ala Val Arg Gly Ile Glu Lys Ala Leu Ser 
                165                 170                 175     


Thr Gln Glu Asp Ser Phe Ile Leu Lys Asp Val His Asp Phe Leu Ser 
            180                 185                 190         


Thr Asn Pro Val Thr Glu Thr Glu Ile Asn Ser Ile Leu Glu Lys Thr 
        195                 200                 205             


Val Lys Val Pro Pro Glu Glu Ile Lys Thr Ile Thr Asp Lys Leu Asp 
    210                 215                 220                 


Arg Ile Leu Leu His Pro Ile Phe Gly Ile Pro Leu Phe Phe Ile Ser 
225                 230                 235                 240 


Met Leu Gly Ile Phe Phe Leu Ile Trp Tyr Leu Gly Leu Pro Ser Gln 
                245                 250                 255     


Asp Ile Met Gly Asn Ile Thr Asp Trp Ile Ser Gly Gln Ile Ile Glu 
            260                 265                 270         


Pro Thr Ile Gln Pro Leu Pro Glu Ile Leu Gln Asn Phe Leu Leu Asn 
        275                 280                 285             


Gly Val Trp Leu Gly Val Ala Thr Val Ala Ser Phe Val Pro Leu Ile 
    290                 295                 300                 


Val Leu Phe Phe Phe Val Met Ala Ala Val Glu Asp Ser Gly Tyr Leu 
305                 310                 315                 320 


Ala Arg Ser Ala Tyr Leu Met Asp Ala Leu Met Glu Lys Leu Gly Leu 
                325                 330                 335     


Asp Gly Arg Ala Phe Val Met Gln Met Met Gly Phe Gly Cys Asn Val 
            340                 345                 350         


Pro Ala Leu Met Gly Thr Arg Val Ile Arg Ser Gln Pro Met Arg Trp 
        355                 360                 365             


Leu Ser Met Leu Ile Ile Pro Phe Ala Leu Cys Ser Ala Arg Leu Ala 
    370                 375                 380                 


Val Phe Val Phe Ile Ile Ala Ala Ile Phe Pro Pro Asn Leu Gly Pro 
385                 390                 395                 400 


Ile Ile Leu Phe Ser Leu Tyr Leu Leu Ser Phe Ile Ala Ser Phe Phe 
                405                 410                 415     


Val Ala Phe Val Phe Ser Lys Thr Lys Glu Phe Gln Ser Gln Glu Pro 
            420                 425                 430         


Phe Ile Ile Glu Leu Pro Pro Tyr Arg Leu Pro Thr Leu Arg Gln Val 
        435                 440                 445             


Leu Leu Arg Gly Trp Gly Glu Val Lys Glu Phe Leu Arg Arg Ala Thr 
    450                 455                 460                 


Asn Phe Ile Ile Ile Gly Cys Val Ala Val Trp Phe Leu Thr Tyr Phe 
465                 470                 475                 480 


Pro Glu Asn Ser Ile Gly Leu Glu Thr Trp Gly Gly Gln Leu Gly Ile 
                485                 490                 495     


Leu Leu Gln Pro Ile Met Gln Pro Ile Gly Ile Asp Pro Tyr Leu Thr 
            500                 505                 510         


Leu Ser Leu Ile Phe Gly Phe Ile Ala Lys Glu Ile Val Val Gly Ser 
        515                 520                 525             


Phe Ala Thr Ile Tyr Gly Leu Ser Ser Ser Ala Leu Thr Gln His Ile 
    530                 535                 540                 


Ala Leu Thr Ile Thr Pro Ala Ala Ala Val Ser Phe Cys Ile Phe Cys 
545                 550                 555                 560 


Leu Leu Tyr Thr Pro Cys Leu Ser Thr Val Ala Thr Ile Lys Ala Glu 
                565                 570                 575     


Ser Lys Ser Thr Ile Phe Thr Leu Phe Ser Leu Leu Phe Ser Leu Val 
            580                 585                 590         


Tyr Ala Trp Ile Cys Ala Phe Ile Phe Tyr His Leu Ala Leu Thr Leu 
        595                 600                 605             


Phe Pro Ile 
    610     


<210>  11
<211>  1308
<212>  DNA
<213>  Synthetic


<220>
<221>  gene
<222>  (1)..(1308)
<223>  HemL (Codon optimized for Cyanobacteria)

<400>  11
ttggtaaaca cagtatcgtt caaaactact aaatccgatg aaatctttgc cgccgcccaa       60

aaattaatgc cgggaggagt taattctcct gtaagagcct ttaaatctgt cggtggacaa      120

cctattgttt ttgaccgtgt aaaaggtgca tatatttggg atgtggacga aaataaatat      180

attgactatg ttgggacttg gggacctgca atttgtggtc atgctcatcc tgaagtcatc      240

aaatctttaa gtgaggcttt ggaaaaaggt acaagttttg gcgctccttg ttatttagaa      300

aatatcctcg ccgaaatggt gattgatgca gtaccaagca ttgagatggt gcgttttgtt      360

aactctggta cagaagcctg tatttctgtt ttaagattga tgagagccta tacaggtaga      420

aacaaaatca tcaagtttga aggttgttat catggccatg gcgatatgtt tttagttaag      480

gcaggttctg gagttgctac cctcggctta ccagattctc ccggagtacc taaaagcgtt      540

acatcagata ctttgactgc accttataac gatttagaag cggtgaaaaa attatttgcc      600

gataatcctg atgaaattgc gggggttatt cttgagcctg tagtgggtaa ctctggtttt      660

attgtccctg atgcgggttt tttagagggt ttaagattaa ttactgagca gaatggtgct      720

ttattggtat tcgatgaagt aatgactggt ttccgcatat cttatggtgg cgctcaagct      780

aaattcggta ttactcccga tttaacaact ttaggaaaag ttattggcgg tggtttacct      840

gtgggtgctt atggtggtaa aaaggaaatc atggcaatgg ttgctccttc tggccccatg      900

tatcaggctg gtactttgtc tggtaatcct ttagctatga cagcaggaat taaaaccctt      960

gaattattac aaaaacccgg cacttatgaa tatttggaag aaattaccca taaactaata     1020

agtggtttat taactattgc taaaaatact ggtcataagg ttactggcgg taatattagt     1080

ggtatgtttg gcatgttttt cactggtgaa gaagttcata attatgatga tgcgaaaaaa     1140

gctgacacca gtaaattcgc ccgttttcat agaggaatgc ttgagagagg agtatattta     1200

gcaccctccc agtttgaggc tggatttact tctattgctc acaccgaaga ggatataaac     1260

caaactttag ctatggcgga agaagttttg aaagaaattc ctgcctaa                  1308


<210>  12
<211>  435
<212>  PRT
<213>  Synthetic


<220>
<221>  PEPTIDE
<222>  (1)..(435)
<223>  HemL protein (Codon optimized for Cyanobacteria)

<400>  12

Met Val Asn Thr Val Ser Phe Lys Thr Thr Lys Ser Asp Glu Ile Phe 
1               5                   10                  15      


Ala Ala Ala Gln Lys Leu Met Pro Gly Gly Val Asn Ser Pro Val Arg 
            20                  25                  30          


Ala Phe Lys Ser Val Gly Gly Gln Pro Ile Val Phe Asp Arg Val Lys 
        35                  40                  45              


Gly Ala Tyr Ile Trp Asp Val Asp Glu Asn Lys Tyr Ile Asp Tyr Val 
    50                  55                  60                  


Gly Thr Trp Gly Pro Ala Ile Cys Gly His Ala His Pro Glu Val Ile 
65                  70                  75                  80  


Lys Ser Leu Ser Glu Ala Leu Glu Lys Gly Thr Ser Phe Gly Ala Pro 
                85                  90                  95      


Cys Tyr Leu Glu Asn Ile Leu Ala Glu Met Val Ile Asp Ala Val Pro 
            100                 105                 110         


Ser Ile Glu Met Val Arg Phe Val Asn Ser Gly Thr Glu Ala Cys Ile 
        115                 120                 125             


Ser Val Leu Arg Leu Met Arg Ala Tyr Thr Gly Arg Asn Lys Ile Ile 
    130                 135                 140                 


Lys Phe Glu Gly Cys Tyr His Gly His Gly Asp Met Phe Leu Val Lys 
145                 150                 155                 160 


Ala Gly Ser Gly Val Ala Thr Leu Gly Leu Pro Asp Ser Pro Gly Val 
                165                 170                 175     


Pro Lys Ser Val Thr Ser Asp Thr Leu Thr Ala Pro Tyr Asn Asp Leu 
            180                 185                 190         


Glu Ala Val Lys Lys Leu Phe Ala Asp Asn Pro Asp Glu Ile Ala Gly 
        195                 200                 205             


Val Ile Leu Glu Pro Val Val Gly Asn Ser Gly Phe Ile Val Pro Asp 
    210                 215                 220                 


Ala Gly Phe Leu Glu Gly Leu Arg Leu Ile Thr Glu Gln Asn Gly Ala 
225                 230                 235                 240 


Leu Leu Val Phe Asp Glu Val Met Thr Gly Phe Arg Ile Ser Tyr Gly 
                245                 250                 255     


Gly Ala Gln Ala Lys Phe Gly Ile Thr Pro Asp Leu Thr Thr Leu Gly 
            260                 265                 270         


Lys Val Ile Gly Gly Gly Leu Pro Val Gly Ala Tyr Gly Gly Lys Lys 
        275                 280                 285             


Glu Ile Met Ala Met Val Ala Pro Ser Gly Pro Met Tyr Gln Ala Gly 
    290                 295                 300                 


Thr Leu Ser Gly Asn Pro Leu Ala Met Thr Ala Gly Ile Lys Thr Leu 
305                 310                 315                 320 


Glu Leu Leu Gln Lys Pro Gly Thr Tyr Glu Tyr Leu Glu Glu Ile Thr 
                325                 330                 335     


His Lys Leu Ile Ser Gly Leu Leu Thr Ile Ala Lys Asn Thr Gly His 
            340                 345                 350         


Lys Val Thr Gly Gly Asn Ile Ser Gly Met Phe Gly Met Phe Phe Thr 
        355                 360                 365             


Gly Glu Glu Val His Asn Tyr Asp Asp Ala Lys Lys Ala Asp Thr Ser 
    370                 375                 380                 


Lys Phe Ala Arg Phe His Arg Gly Met Leu Glu Arg Gly Val Tyr Leu 
385                 390                 395                 400 


Ala Pro Ser Gln Phe Glu Ala Gly Phe Thr Ser Ile Ala His Thr Glu 
                405                 410                 415     


Glu Asp Ile Asn Gln Thr Leu Ala Met Ala Glu Glu Val Leu Lys Glu 
            420                 425                 430         


Ile Pro Ala 
        435 


<210>  13
<211>  1158
<212>  DNA
<213>  Synthetic


<220>
<221>  gene
<222>  (1)..(1158)
<223>  HemH (Codon optimized for Cyanobacteria)

<400>  13
gtggtagtta ctccggaaaa aactattgaa tcaaattcag tctcacctgc tacagataga       60

gtagccgtta ttcttatggg atatggagag gtggaaagtt atgatgattt tgccaactat      120

aatgaacaag ccttaaacct acttacggca aaatttgccc ctgtgccaac atggttatat      180

cccccccttg ctaaattgtt agcggttttc gatttacatg aatggagtca tcaacacggc      240

aattttgttt ctcctcataa tgctattttc gagcgtcaaa gagcaaaaat tgagcatcag      300

ttgcaacaca cttggggaga aaaagtcaaa gtatttaagg ctttcaactt ctgtaaacct      360

catttaccct atcaagtttt agagcaggtt aaagctgaag gatttgagaa aattctcatt      420

tatcccctct tagtagttga ttctatcttc accagtggaa ttgcgatcga gcaaataaac      480

gaggcgttag cacaaaaaga caaaaaagaa gaccattggg ttaaagcctt acgttatata      540

ccttctttct acaataaacc agagtatatc gatttattag ctaaattagt agaagaagaa      600

atcgacgcaa aattaagcaa tgcttattta ccttcagaaa ttggtattgt tttaatgaat      660

cacggttgcc ctcatgaagc aaaaggattt acttcgggta ttgatgaaag tcaagcctta      720

tatgaattgg taagagaaaa actcatttat cgttatccct taatttccgt aggttggctc      780

aaccatcaaa cccctctaat taaatggact caacctaatg cggagttagc aggaagaaac      840

ttgattgagt taggggcaaa agccttaata tttatgccca ttggctttgc aacggaaaac      900

catgaaacct tgttagatgt agaacacatt attcaagcat tatacgttaa atatcccgat      960

gtcaattatg tccagatgga atgcgttaac gataatgaag aattttgtgc tatggcggca     1020

caatgggtta atcctttgat tgaatcctta ttaacggaag aaggggctgt aattaatcct     1080

agttttgcca aaacccatta tcatggtcat catcaccacg atcatgatca taatcacaat     1140

catcatcacc atcattaa                                                   1158


<210>  14
<211>  385
<212>  PRT
<213>  Synthetic


<220>
<221>  PEPTIDE
<222>  (1)..(385)
<223>  HemH protein (Codon optimized for Cyanobacteria)

<400>  14

Met Val Val Thr Pro Glu Lys Thr Ile Glu Ser Asn Ser Val Ser Pro 
1               5                   10                  15      


Ala Thr Asp Arg Val Ala Val Ile Leu Met Gly Tyr Gly Glu Val Glu 
            20                  25                  30          


Ser Tyr Asp Asp Phe Ala Asn Tyr Asn Glu Gln Ala Leu Asn Leu Leu 
        35                  40                  45              


Thr Ala Lys Phe Ala Pro Val Pro Thr Trp Leu Tyr Pro Pro Leu Ala 
    50                  55                  60                  


Lys Leu Leu Ala Val Phe Asp Leu His Glu Trp Ser His Gln His Gly 
65                  70                  75                  80  


Asn Phe Val Ser Pro His Asn Ala Ile Phe Glu Arg Gln Arg Ala Lys 
                85                  90                  95      


Ile Glu His Gln Leu Gln His Thr Trp Gly Glu Lys Val Lys Val Phe 
            100                 105                 110         


Lys Ala Phe Asn Phe Cys Lys Pro His Leu Pro Tyr Gln Val Leu Glu 
        115                 120                 125             


Gln Val Lys Ala Glu Gly Phe Glu Lys Ile Leu Ile Tyr Pro Leu Leu 
    130                 135                 140                 


Val Val Asp Ser Ile Phe Thr Ser Gly Ile Ala Ile Glu Gln Ile Asn 
145                 150                 155                 160 


Glu Ala Leu Ala Gln Lys Asp Lys Lys Glu Asp His Trp Val Lys Ala 
                165                 170                 175     


Leu Arg Tyr Ile Pro Ser Phe Tyr Asn Lys Pro Glu Tyr Ile Asp Leu 
            180                 185                 190         


Leu Ala Lys Leu Val Glu Glu Glu Ile Asp Ala Lys Leu Ser Asn Ala 
        195                 200                 205             


Tyr Leu Pro Ser Glu Ile Gly Ile Val Leu Met Asn His Gly Cys Pro 
    210                 215                 220                 


His Glu Ala Lys Gly Phe Thr Ser Gly Ile Asp Glu Ser Gln Ala Leu 
225                 230                 235                 240 


Tyr Glu Leu Val Arg Glu Lys Leu Ile Tyr Arg Tyr Pro Leu Ile Ser 
                245                 250                 255     


Val Gly Trp Leu Asn His Gln Thr Pro Leu Ile Lys Trp Thr Gln Pro 
            260                 265                 270         


Asn Ala Glu Leu Ala Gly Arg Asn Leu Ile Glu Leu Gly Ala Lys Ala 
        275                 280                 285             


Leu Ile Phe Met Pro Ile Gly Phe Ala Thr Glu Asn His Glu Thr Leu 
    290                 295                 300                 


Leu Asp Val Glu His Ile Ile Gln Ala Leu Tyr Val Lys Tyr Pro Asp 
305                 310                 315                 320 


Val Asn Tyr Val Gln Met Glu Cys Val Asn Asp Asn Glu Glu Phe Cys 
                325                 330                 335     


Ala Met Ala Ala Gln Trp Val Asn Pro Leu Ile Glu Ser Leu Leu Thr 
            340                 345                 350         


Glu Glu Gly Ala Val Ile Asn Pro Ser Phe Ala Lys Thr His Tyr His 
        355                 360                 365             


Gly His His His His Asp His Asp His Asn His Asn His His His His 
    370                 375                 380                 


His 
385 


<210>  15
<211>  426
<212>  PRT
<213>  Synthetic


<220>
<221>  PEPTIDE
<222>  (1)..(426)
<223>  HemL protein (Codon optimized for E. coli)

<400>  15

Met Ser Lys Ser Glu Asn Leu Tyr Ser Ala Ala Arg Glu Leu Ile Pro 
1               5                   10                  15      


Gly Gly Val Asn Ser Pro Val Arg Ala Phe Thr Gly Val Gly Gly Thr 
            20                  25                  30          


Pro Leu Phe Ile Glu Lys Ala Asp Gly Ala Tyr Leu Tyr Asp Val Asp 
        35                  40                  45              


Gly Lys Ala Tyr Ile Asp Tyr Val Gly Ser Trp Gly Pro Met Val Leu 
    50                  55                  60                  


Gly His Asn His Pro Ala Ile Arg Asn Ala Val Ile Glu Ala Ala Glu 
65                  70                  75                  80  


Arg Gly Leu Ser Phe Gly Ala Pro Thr Glu Met Glu Val Lys Met Ala 
                85                  90                  95      


Gln Leu Val Thr Glu Leu Val Pro Thr Met Asp Met Val Arg Met Val 
            100                 105                 110         


Asn Ser Gly Thr Glu Ala Thr Met Ser Ala Ile Arg Leu Ala Arg Gly 
        115                 120                 125             


Phe Thr Gly Arg Asp Lys Ile Ile Lys Phe Glu Gly Cys Tyr His Gly 
    130                 135                 140                 


His Ala Asp Cys Leu Leu Val Lys Ala Gly Ser Gly Ala Leu Thr Leu 
145                 150                 155                 160 


Gly Gln Pro Asn Ser Pro Gly Val Pro Ala Asp Phe Ala Lys Tyr Thr 
                165                 170                 175     


Leu Thr Cys Thr Tyr Asn Asp Leu Ala Ser Val Arg Ala Ala Phe Glu 
            180                 185                 190         


Gln Tyr Pro Gln Glu Ile Ala Cys Ile Ile Val Glu Pro Val Ala Gly 
        195                 200                 205             


Asn Met Asn Cys Val Pro Pro Leu Pro Glu Phe Leu Pro Gly Leu Arg 
    210                 215                 220                 


Ala Leu Cys Asp Glu Phe Gly Ala Leu Leu Ile Ile Asp Glu Val Met 
225                 230                 235                 240 


Thr Gly Phe Arg Val Ala Leu Ala Gly Ala Gln Asp Tyr Tyr Gly Val 
                245                 250                 255     


Val Pro Asp Leu Thr Cys Leu Gly Lys Ile Ile Gly Gly Gly Met Pro 
            260                 265                 270         


Val Gly Ala Phe Gly Gly Arg Arg Asp Val Met Asp Ala Leu Ala Pro 
        275                 280                 285             


Thr Gly Pro Val Tyr Gln Ala Gly Thr Leu Ser Gly Asn Pro Ile Ala 
    290                 295                 300                 


Met Ala Ala Gly Phe Ala Cys Leu Asn Glu Val Ala Gln Pro Gly Val 
305                 310                 315                 320 


His Glu Thr Leu Asp Glu Leu Thr Thr Arg Leu Ala Glu Gly Leu Leu 
                325                 330                 335     


Glu Ala Ala Glu Glu Ala Gly Ile Pro Leu Val Val Asn His Val Gly 
            340                 345                 350         


Gly Met Phe Gly Ile Phe Phe Thr Asp Ala Glu Ser Val Thr Cys Tyr 
        355                 360                 365             


Gln Asp Val Met Ala Cys Asp Val Glu Arg Phe Lys Arg Phe Phe His 
    370                 375                 380                 


Met Met Leu Asp Glu Gly Val Tyr Leu Ala Pro Ser Ala Phe Glu Ala 
385                 390                 395                 400 


Gly Phe Met Ser Val Ala His Ser Met Glu Asp Ile Asn Asn Thr Ile 
                405                 410                 415     


Asp Ala Ala Arg Arg Val Phe Ala Lys Leu 
            420                 425     


<210>  16
<211>  1281
<212>  DNA
<213>  Synthetic


<220>
<221>  gene
<222>  (1)..(1281)

<400>  16
atgagtaagt ctgaaaatct ttacagcgca gcgcgcgagc tgatccctgg cggtgtgaac       60

tcccctgttc gcgcctttac tggcgtgggc ggcactccac tgtttatcga aaaagcggac      120

ggcgcttatc tgtacgatgt tgatggcaaa gcctatatcg attatgtcgg ttcctggggg      180

ccgatggtgc tgggccataa ccatccggca atccgcaatg ccgtgattga agccgccgag      240

cgtggtttaa gctttggtgc accaaccgaa atggaagtga aaatggcgca actggtgacc      300

gaactggtcc cgaccatgga tatggtgcgc atggtgaact ccggcactga agcgaccatg      360

agcgccatcc gcctggcccg tggttttacc ggtcgcgaca aaattattaa atttgaaggg      420

tgttaccatg gtcacgctga ctgcctgctg gtgaaagccg gttctggcgc actcacgtta      480

ggccagccaa actcgccggg cgttccggca gatttcgcca aatatacctt aacctgtact      540

tataatgatc tggcttctgt acgcgccgca tttgagcaat acccgcaaga gattgcctgt      600

attatcgtcg agccggtggc aggcaatatg aactgtgttc cgccgctgcc agagttcctg      660

ccaggtctgc gcgcgctgtg cgacgaattt ggcgcgttgc tgatcatcga tgaagtgatg      720

accggtttcc gcgtagcgct agctggcgca caggattatt acggcgtagt gccagattta      780

acctgcctcg gcaaaatcat cggcggtgga atgccggtag gcgcattcgg tggtcgtcgt      840

gatgtaatgg atgcgctggc cccgacgggt ccggtctatc aggcgggtac gctttccggt      900

aacccgattg cgatggcagc gggtttcgcc tgtctgaatg aagtcgcgca gccgggcgtt      960

cacgaaacgc tggatgagct gacaacacgt ctggcagaag gtctgctgga agcggcagaa     1020

gaagccggaa ttccgctggt cgttaaccac gttggcggca tgttcggtat tttctttacc     1080

gacgccgagt ccgtgacgtg ctatcaggat gtgatggcct gtgacgtgga acgctttaag     1140

cgtttcttcc atatgatgct ggacgaaggt gtttacctgg caccgtcagc gtttgaagcg     1200

ggctttatgt ccgtggcgca cagcatggaa gatatcaata acaccatcga tgctgcacgt     1260

cgggtgtttg cgaagttgtg a                                               1281


<210>  17
<211>  320
<212>  PRT
<213>  Synthetic


<220>
<221>  PEPTIDE
<222>  (1)..(320)
<223>  HemH protein (Codon optimized for E. coli)

<400>  17

Met Arg Gln Thr Lys Thr Gly Ile Leu Leu Ala Asn Leu Gly Thr Pro 
1               5                   10                  15      


Asp Ala Pro Thr Pro Glu Ala Val Lys Arg Tyr Leu Lys Gln Phe Leu 
            20                  25                  30          


Ser Asp Arg Arg Val Val Asp Thr Ser Arg Leu Leu Trp Trp Pro Leu 
        35                  40                  45              


Leu Arg Gly Val Ile Leu Pro Leu Arg Ser Pro Arg Val Ala Lys Leu 
    50                  55                  60                  


Tyr Ala Ser Val Trp Met Glu Gly Gly Ser Pro Leu Met Val Tyr Ser 
65                  70                  75                  80  


Arg Gln Gln Gln Gln Ala Leu Ala Gln Arg Leu Pro Glu Met Pro Val 
                85                  90                  95      


Ala Leu Gly Met Ser Tyr Gly Ser Pro Ser Leu Glu Ser Ala Val Asp 
            100                 105                 110         


Glu Leu Leu Ala Glu His Val Asp His Ile Val Val Leu Pro Leu Tyr 
        115                 120                 125             


Pro Gln Phe Ser Cys Ser Thr Val Gly Ala Val Trp Asp Glu Leu Ala 
    130                 135                 140                 


Arg Ile Leu Ala Arg Lys Arg Ser Ile Pro Gly Ile Ser Phe Ile Arg 
145                 150                 155                 160 


Asp Tyr Ala Asp Asn His Asp Tyr Ile Asn Ala Leu Ala Asn Ser Val 
                165                 170                 175     


Arg Ala Ser Phe Ala Lys His Gly Glu Pro Asp Leu Leu Leu Leu Ser 
            180                 185                 190         


Tyr His Gly Ile Pro Gln Arg Tyr Ala Asp Glu Gly Asp Asp Tyr Pro 
        195                 200                 205             


Gln Arg Cys Arg Thr Thr Thr Arg Glu Leu Ala Ser Ala Leu Gly Met 
    210                 215                 220                 


Ala Pro Glu Lys Val Met Met Thr Phe Gln Ser Arg Phe Gly Arg Glu 
225                 230                 235                 240 


Pro Trp Leu Met Pro Tyr Thr Asp Glu Thr Leu Lys Met Leu Gly Glu 
                245                 250                 255     


Lys Gly Val Gly His Ile Gln Val Met Cys Pro Gly Phe Ala Ala Asp 
            260                 265                 270         


Cys Leu Glu Thr Leu Glu Glu Ile Ala Glu Gln Asn Arg Glu Val Phe 
        275                 280                 285             


Leu Gly Ala Gly Gly Lys Lys Tyr Glu Tyr Ile Pro Ala Leu Asn Ala 
    290                 295                 300                 


Thr Pro Glu His Ile Glu Met Met Ala Asn Leu Val Ala Ala Tyr Arg 
305                 310                 315                 320 


<210>  18
<211>  963
<212>  DNA
<213>  Synthetic


<220>
<221>  gene
<222>  (1)..(963)
<223>  HemH (Codon optimized for E. coli)

<400>  18
atgcgtcaga ctaaaaccgg tatcctgctg gcaaacctgg gtacgcccga tgcccccaca       60

cctgaagcgg taaaacgcta tctgaaacaa tttttaagcg acagacgcgt ggttgatacc      120

tcacggttgt tatggtggcc attgctgcgc ggcgtgattt tgccgctgcg ctcgccgcgt      180

gtggcgaagc tgtatgcctc tgtctggatg gaaggtggct cgccgctgat ggtttacagc      240

cgccagcaac agcaggcgct ggcacaacgt ttaccggaga tgcccgtagc gctgggaatg      300

agctacggct cgccatcact ggaaagcgcc gtagatgaac tcctggcaga gcatgtagat      360

catattgtgg tgctgccgct ttatccgcaa ttctcctgtt ctacggtcgg tgcggtatgg      420

gatgaactgg cacgcattct ggcgcgcaaa cgtagcattc cggggatatc gtttatacgt      480

gattacgccg ataaccacga ttacattaat gcactggcga acagcgtacg cgcttctttt      540

gccaaacatg gcgaaccgga tctgctactg ctctcttatc atggcattcc ccagcgttat      600

gcagatgaag gcgatgatta cccgcaacgt tgccgcacaa cgactcgtga actggcttcc      660

gcattgggga tggcaccgga aaaagtgatg atgacctttc agtcgcgctt tggtcgggaa      720

ccctggctga tgccttatac cgacgaaacg ctgaaaatgc tcggagaaaa aggcgtaggt      780

catattcagg tgatgtgccc gggctttgct gcggattgtc tggagacgct ggaagagatt      840

gccgagcaaa accgtgaggt cttcctcggt gccggcggga aaaaatatga atatattccg      900

gcgcttaatg ccacgccgga acatatcgaa atgatggcta atcttgttgc cgcgtatcgc      960

taa                                                                    963


<210>  19
<211>  773
<212>  PRT
<213>  Synthetic


<220>
<221>  PEPTIDE
<222>  (1)..(773)
<223>  FeoB protein (Codon optimized for E. coli)

<400>  19

Met Lys Lys Leu Thr Ile Gly Leu Ile Gly Asn Pro Asn Ser Gly Lys 
1               5                   10                  15      


Thr Thr Leu Phe Asn Gln Leu Thr Gly Ser Arg Gln Arg Val Gly Asn 
            20                  25                  30          


Trp Ala Gly Val Thr Val Glu Arg Lys Glu Gly Gln Phe Ser Thr Thr 
        35                  40                  45              


Asp His Gln Val Thr Leu Val Asp Leu Pro Gly Thr Tyr Ser Leu Thr 
    50                  55                  60                  


Thr Ile Ser Ser Gln Thr Ser Leu Asp Glu Gln Ile Ala Cys His Tyr 
65                  70                  75                  80  


Ile Leu Ser Gly Asp Ala Asp Leu Leu Ile Asn Val Val Asp Ala Ser 
                85                  90                  95      


Asn Leu Glu Arg Asn Leu Tyr Leu Thr Leu Gln Leu Leu Glu Leu Gly 
            100                 105                 110         


Ile Pro Cys Ile Val Ala Leu Asn Met Leu Asp Ile Ala Glu Lys Gln 
        115                 120                 125             


Asn Ile Arg Ile Glu Ile Asp Ala Leu Ser Ala Arg Leu Gly Cys Pro 
    130                 135                 140                 


Val Ile Pro Leu Val Ser Thr Arg Gly Arg Gly Ile Glu Ala Leu Lys 
145                 150                 155                 160 


Leu Ala Ile Asp Arg Tyr Lys Ala Asn Glu Asn Val Glu Leu Val His 
                165                 170                 175     


Tyr Ala Gln Pro Leu Leu Asn Glu Ala Asp Ser Leu Ala Lys Val Met 
            180                 185                 190         


Pro Ser Asp Ile Pro Leu Lys Gln Arg Arg Trp Leu Gly Leu Gln Met 
        195                 200                 205             


Leu Glu Gly Asp Ile Tyr Ser Arg Ala Tyr Ala Gly Glu Ala Ser Gln 
    210                 215                 220                 


His Leu Asp Ala Ala Leu Ala Arg Leu Arg Asn Glu Met Asp Asp Pro 
225                 230                 235                 240 


Ala Leu His Ile Ala Asp Ala Arg Tyr Gln Cys Ile Ala Ala Ile Cys 
                245                 250                 255     


Asp Val Val Ser Asn Thr Leu Thr Ala Glu Pro Ser Arg Phe Thr Thr 
            260                 265                 270         


Ala Val Asp Lys Ile Val Leu Asn Arg Phe Leu Gly Leu Pro Ile Phe 
        275                 280                 285             


Leu Phe Val Met Tyr Leu Met Phe Leu Leu Ala Ile Asn Ile Gly Gly 
    290                 295                 300                 


Ala Leu Gln Pro Leu Phe Asp Val Gly Ser Val Ala Leu Phe Val His 
305                 310                 315                 320 


Gly Ile Gln Trp Ile Gly Tyr Thr Leu His Phe Pro Asp Trp Leu Thr 
                325                 330                 335     


Ile Phe Leu Ala Gln Gly Leu Gly Gly Gly Ile Asn Thr Val Leu Pro 
            340                 345                 350         


Leu Val Pro Gln Ile Gly Met Met Tyr Leu Phe Leu Ser Phe Leu Glu 
        355                 360                 365             


Asp Ser Gly Tyr Met Ala Arg Ala Ala Phe Val Met Asp Arg Leu Met 
    370                 375                 380                 


Gln Ala Leu Gly Leu Pro Gly Lys Ser Phe Val Pro Leu Ile Val Gly 
385                 390                 395                 400 


Phe Gly Cys Asn Val Pro Ser Val Met Gly Ala Arg Thr Leu Asp Ala 
                405                 410                 415     


Pro Arg Glu Arg Leu Met Thr Ile Met Met Ala Pro Phe Met Ser Cys 
            420                 425                 430         


Gly Ala Arg Leu Ala Ile Phe Ala Val Phe Ala Ala Ala Phe Phe Gly 
        435                 440                 445             


Gln Asn Gly Ala Leu Ala Val Phe Ser Leu Tyr Met Leu Gly Ile Val 
    450                 455                 460                 


Met Ala Val Leu Thr Gly Leu Met Leu Lys Tyr Thr Ile Met Arg Gly 
465                 470                 475                 480 


Glu Ala Thr Pro Phe Val Met Glu Leu Pro Val Tyr His Val Pro His 
                485                 490                 495     


Val Lys Ser Leu Ile Ile Gln Thr Trp Gln Arg Leu Lys Gly Phe Val 
            500                 505                 510         


Leu Arg Ala Gly Lys Val Ile Ile Ile Val Ser Ile Phe Leu Ser Ala 
        515                 520                 525             


Phe Asn Ser Phe Ser Leu Ser Gly Lys Ile Val Asp Asn Ile Asn Asp 
    530                 535                 540                 


Ser Ala Leu Ala Ser Val Ser Arg Val Ile Thr Pro Val Phe Lys Pro 
545                 550                 555                 560 


Ile Gly Val His Glu Asp Asn Trp Gln Ala Thr Val Gly Leu Phe Thr 
                565                 570                 575     


Gly Ala Met Ala Lys Glu Val Val Val Gly Thr Leu Asn Thr Leu Tyr 
            580                 585                 590         


Thr Ala Glu Asn Ile Gln Asp Glu Glu Phe Asn Pro Ala Glu Phe Asn 
        595                 600                 605             


Leu Gly Glu Glu Leu Phe Ser Ala Ile Asp Glu Thr Trp Gln Ser Leu 
    610                 615                 620                 


Lys Asp Thr Phe Ser Leu Ser Val Leu Met Asn Pro Ile Glu Ala Ser 
625                 630                 635                 640 


Lys Gly Asp Gly Glu Met Gly Thr Gly Ala Met Gly Val Met Asp Gln 
                645                 650                 655     


Lys Phe Gly Ser Ala Ala Ala Ala Tyr Ser Tyr Leu Ile Phe Val Leu 
            660                 665                 670         


Leu Tyr Val Pro Cys Ile Ser Val Met Gly Ala Ile Ala Arg Glu Ser 
        675                 680                 685             


Ser Arg Gly Trp Met Gly Phe Ser Ile Leu Trp Gly Leu Asn Ile Ala 
    690                 695                 700                 


Tyr Ser Leu Ala Thr Leu Phe Tyr Gln Val Ala Ser Tyr Ser Gln His 
705                 710                 715                 720 


Pro Thr Tyr Ser Leu Val Cys Ile Leu Ala Val Ile Leu Phe Asn Ile 
                725                 730                 735     


Val Val Ile Gly Leu Leu Arg Arg Ala Arg Ser Arg Val Asp Ile Glu 
            740                 745                 750         


Leu Leu Ala Thr Arg Lys Ser Val Ser Ser Cys Cys Ala Ala Ser Thr 
        755                 760                 765             


Thr Gly Asp Cys His 
    770             


<210>  20
<211>  2322
<212>  DNA
<213>  Synthetic


<220>
<221>  gene
<222>  (1)..(2322)
<223>  FeoB gene (Codon optimized for E. coli)

<400>  20
atgaaaaaat taaccattgg cttaattggt aatccaaatt ctggcaagac aacgttattt       60

aaccagctca ctggctcacg tcagcgtgta ggtaactggg ctggcgttac cgtcgaacgt      120

aaagaagggc aattctccac caccgatcat caggtcacgc tggtggacct gcccggcacc      180

tattctctga ccaccatctc atcgcagacc tcgctcgatg agcaaatcgc ctgtcactac      240

attttgagtg gcgacgccga cctgctgatt aacgtggtgg atgcgtctaa ccttgagcgt      300

aacctgtacc tgacgctaca actgctggaa ctcggcattc cctgcattgt ggcactgaac      360

atgctcgaca ttgccgagaa gcaaaatatt cgtattgaaa ttgatgctct gtcggcgcgt      420

ctgggctgtc cggtgatccc gctggtttca acccgtggtc gcggtattga agcgctcaag      480

ctggcgattg atcgctataa agctaacgag aatgtggaac tggtgcatta cgcacagccg      540

ctgctcaacg aagcagattc actggcaaaa gtgatgcctt ccgacatccc gctgaaacaa      600

cgtcgctggc tgggcctgca aatgctggaa ggcgatatct acagccgcgc ctacgccggt      660

gaagcgtcgc agcatctgga tgccgccctc gcccgtctgc gtaatgagat ggacgatccg      720

gcgctgcaca ttgccgatgc gcgttaccag tgcattgctg ccatctgtga tgtggtaagc      780

aacaccctga cggcagaacc cagccgtttc accactgcgg tagataaaat cgtgctcaac      840

cgtttcctcg gtctgccgat tttcctcttt gtgatgtacc tgatgttcct gctggctatc      900

aacatcggcg gggcgttaca gccgctgttt gacgtcggct ccgtggcgct atttgtgcat      960

ggtattcaat ggattggcta cacgctccac ttcccggact ggctgactat cttcctcgcc     1020

cagggcctgg gtggcggcat taacaccgtg ctgccactgg tgccgcagat tggcatgatg     1080

tacctgttcc tctccttcct tgaggactcc gggtatatgg cgcgtgcggc gtttgtgatg     1140

gaccgtctga tgcaggcgct gggcttgccg gggaaatcct ttgtgccgct gatcgtcggt     1200

ttcggttgta acgtaccgtc ggtaatgggt gcacgtacgc ttgatgcacc gcgtgaacgt     1260

ctgatgacca tcatgatggc accgtttatg tcctgcggcg cgcgtctggc tatcttcgca     1320

gtattcgcgg ctgccttctt cgggcagaac ggtgcgctgg cggtcttctc gctgtatatg     1380

ctgggtattg tgatggcggt gctgactggc ctgatgctca agtacaccat catgcgcggt     1440

gaagcgacgc cgtttgtcat ggagttgccg gtctatcatg taccacacgt taaaagcctg     1500

attatccaga cctggcagcg tctgaaaggc ttcgttctgc gtgctggtaa agtgatcatc     1560

atcgtcagca ttttcctgag cgctttcaac agcttctcgc tgagcgggaa aatcgtcgat     1620

aacatcaacg actcggcgct ggcgtccgtc agccgggtga tcaccccggt cttcaagcca     1680

attggcgtgc atgaagataa ctggcaggca acggttggcc tgtttacagg tgccatggcg     1740

aaagaagtgg tagtgggtac gctcaacacc ctctacaccg cagaaaatat tcaggacgaa     1800

gagttcaatc cggcagaatt taacctcggt gaagagctgt tcagtgcgat agatgaaacc     1860

tggcagagcc tgaaagacac cttcagcctt agcgtactga tgaaccccat tgaagccagc     1920

aaaggcgacg gcgaaatggg taccggggcg atgggcgtga tggatcagaa attcggtagc     1980

gcagcagcag cttacagcta cctgattttc gtcctgctgt atgtaccatg tatctcggtg     2040

atgggggcta tcgcccgtga atcaagccgt ggctggatgg gcttctccat cctgtggggg     2100

ctgaatatcg cttactcact ggcaacattg ttctatcagg tcgccagcta cagtcagcat     2160

ccaacttaca gcctggtgtg cattctggcg gttatcctgt ttaacatcgt ggttatcggt     2220

ctgctgcgcc gcgcgcgtag ccgggtggat atcgaactgc tggcaacccg caagtcggta     2280

agcagttgct gcgcagccag caccaccggt gattgccatt aa                        2322


<210>  21
<211>  6916
<212>  DNA
<213>  Synthetic


<220>
<221>  gene
<222>  (1)..(6916)
<223>  Plasmid (pPS16)

<400>  21
atccggatat agttcctcct ttcagcaaaa aacccctcaa gacccgttta gaggccccaa       60

ggggttatgc tagttattgc tcagcggtgg cagcagccaa ctcagcttcc tttcgggctt      120

tgttagcagc cggatctcag tggtggtggt ggtggtgctc gagagccact acctcggcac      180

gattaagagc acagtgctgc cataagacgt ccattgcttt aactaagtga tcgatcatcc      240

cagagtcgtg aacaggtgaa ggagtgaaac gcaagcgctc ggttccacga ggaactgtcg      300

ggaagttgat aggctgtaca taaatgccga agtgttccag cagcatgtca gaaatcatct      360

tgcagtggac cggatcgccg acgtgtacag ggacgatatg agacccgtga tcaataatag      420

gcagacccaa tcccttcaaa cgcatcttta aaatacgcgc ctgtgtctgg tgcttctcac      480

gtaattctac gtcacccttc aggtggcgaa cggaagcagc ggccccagcg gcgaccaccg      540

gcggcagaga agtggagaaa ataaatcccg gagcatatga gcgtaccgca tcacacatct      600

tagaagaggc ggcaatatac cctccgaaaa ctccgtaggc tttacccagc gtgccgttaa      660

taatgtcgat gcggtccatc agtccgtcac gttcagcaac accaccaccg cgcggtccat      720

acattcccac cgcgtgtact tcatcaatgt actttaatgc tccaaattca tctgcgatgt      780

cgcaaatttc ctcaatgcgt ccgaagtcac cgtccatact atatacactc tcgaacgcaa      840

ccaaaattgg gcgatccttc ccaatgctgg taagaatgcg gcgcaaatca tccaggtcat      900

tatgtttgaa gatgtgtttt tcagttcccg agcggcggat cccttcgatc atactagcat      960

gattcagctt gtcggagaca atgacaagtc cgggaataag ttgaggcaac gtagacaacg     1020

tagcgtcgtt tgcgatgtat gctgagctaa agactaacgc tgcttccttc ccatgtaaat     1080

ctgccagttc tgcttccaga cgtttatgat ataatgttgt gccggagata ttgcgggtac     1140

ccccagaccc cgcacctgtc gagtcaagtg cctcgtgcat tgctccaaga actaccgggt     1200

gctgtcccat ccccaagtaa tcgttgccgc accagaccgt aatctctttc tcagatccat     1260

ccggcttacg ccacatagcc ttcgggaaag cgcccttgcg gcgttcgatg tcgatgaatg     1320

tgcgataacg cccttcagtg tgtaaacggt tcaatgcagt atctaatgcc aagttataat     1380

ccatggtata tctccttctt aaagtctcga gctatcggtt taaaacatca tttcgatggg     1440

atagagcccc gacaatcgcc ccaacttcgt caattaaatt ttgttcgata cctaactctt     1500

tgagagtatt gatcaaattt tctgcgatcg catcaaaatg aacatccgtt aaacccatat     1560

tatctactaa atgtttatgg gattctcgca tatctctacc agaaaaagta tcaggacctc     1620

caaaagcata agtcataaaa gccttttgat gagctttttg tttcttcata tccgtattgg     1680

caaagaaata attaactcgg tcatccttta acaccttatc atagaactta tcgactgcaa     1740

tatctacagc ttctttaccg cctaattttt cgtacaaact actcatatgg ctgccgcgcg     1800

gcaccaggcc gctgctgtga tgatgatgat gatggctgct gcccatggta tatctccttc     1860

ttaaagttaa acaaaattat ttctagaggg gaattgttat ccgctcacaa ttcccctata     1920

gtgagtcgta ttaatttcgc gggatcgaga tctcgatcct ctacgccgga cgcatcgtgg     1980

ccggcatcac cggcgccaca ggtgcggttg ctggcgccta tatcgccgac atcaccgatg     2040

gggaagatcg ggctcgccac ttcgggctca tgagcgcttg tttcggcgtg ggtatggtgg     2100

caggccccgt ggccggggga ctgttgggcg ccatctcctt gcatgcacca ttccttgcgg     2160

cggcggtgct caacggcctc aacctactac tgggctgctt cctaatgcag gagtcgcata     2220

agggagagcg tcgagatccc ggacaccatc gaatggcgca aaacctttcg cggtatggca     2280

tgatagcgcc cggaagagag tcaattcagg gtggtgaatg tgaaaccagt aacgttatac     2340

gatgtcgcag agtatgccgg tgtctcttat cagaccgttt cccgcgtggt gaaccaggcc     2400

agccacgttt ctgcgaaaac gcgggaaaaa gtggaagcgg cgatggcgga gctgaattac     2460

attcccaacc gcgtggcaca acaactggcg ggcaaacagt cgttgctgat tggcgttgcc     2520

acctccagtc tggccctgca cgcgccgtcg caaattgtcg cggcgattaa atctcgcgcc     2580

gatcaactgg gtgccagcgt ggtggtgtcg atggtagaac gaagcggcgt cgaagcctgt     2640

aaagcggcgg tgcacaatct tctcgcgcaa cgcgtcagtg ggctgatcat taactatccg     2700

ctggatgacc aggatgccat tgctgtggaa gctgcctgca ctaatgttcc ggcgttattt     2760

cttgatgtct ctgaccagac acccatcaac agtattattt tctcccatga agacggtacg     2820

cgactgggcg tggagcatct ggtcgcattg ggtcaccagc aaatcgcgct gttagcgggc     2880

ccattaagtt ctgtctcggc gcgtctgcgt ctggctggct ggcataaata tctcactcgc     2940

aatcaaattc agccgatagc ggaacgggaa ggcgactgga gtgccatgtc cggttttcaa     3000

caaaccatgc aaatgctgaa tgagggcatc gttcccactg cgatgctggt tgccaacgat     3060

cagatggcgc tgggcgcaat gcgcgccatt accgagtccg ggctgcgcgt tggtgcggat     3120

atctcggtag tgggatacga cgataccgaa gacagctcat gttatatccc gccgttaacc     3180

accatcaaac aggattttcg cctgctgggg caaaccagcg tggaccgctt gctgcaactc     3240

tctcagggcc aggcggtgaa gggcaatcag ctgttgcccg tctcactggt gaaaagaaaa     3300

accaccctgg cgcccaatac gcaaaccgcc tctccccgcg cgttggccga ttcattaatg     3360

cagctggcac gacaggtttc ccgactggaa agcgggcagt gagcgcaacg caattaatgt     3420

aagttagctc actcattagg caccgggatc tcgaccgatg cccttgagag ccttcaaccc     3480

agtcagctcc ttccggtggg cgcggggcat gactatcgtc gccgcactta tgactgtctt     3540

ctttatcatg caactcgtag gacaggtgcc ggcagcgctc tgggtcattt tcggcgagga     3600

ccgctttcgc tggagcgcga cgatgatcgg cctgtcgctt gcggtattcg gaatcttgca     3660

cgccctcgct caagccttcg tcactggtcc cgccaccaaa cgtttcggcg agaagcaggc     3720

cattatcgcc ggcatggcgg ccccacgggt gcgcatgatc gtgctcctgt cgttgaggac     3780

ccggctaggc tggcggggtt gccttactgg ttagcagaat gaatcaccga tacgcgagcg     3840

aacgtgaagc gactgctgct gcaaaacgtc tgcgacctga gcaacaacat gaatggtctt     3900

cggtttccgt gtttcgtaaa gtctggaaac gcggaagtca gcgccctgca ccattatgtt     3960

ccggatctgc atcgcaggat gctgctggct accctgtgga acacctacat ctgtattaac     4020

gaagcgctgg cattgaccct gagtgatttt tctctggtcc cgccgcatcc ataccgccag     4080

ttgtttaccc tcacaacgtt ccagtaaccg ggcatgttca tcatcagtaa cccgtatcgt     4140

gagcatcctc tctcgtttca tcggtatcat tacccccatg aacagaaatc ccccttacac     4200

ggaggcatca gtgaccaaac aggaaaaaac cgcccttaac atggcccgct ttatcagaag     4260

ccagacatta acgcttctgg agaaactcaa cgagctggac gcggatgaac aggcagacat     4320

ctgtgaatcg cttcacgacc acgctgatga gctttaccgc agctgcctcg cgcgtttcgg     4380

tgatgacggt gaaaacctct gacacatgca gctcccggag acggtcacag cttgtctgta     4440

agcggatgcc gggagcagac aagcccgtca gggcgcgtca gcgggtgttg gcgggtgtcg     4500

gggcgcagcc atgacccagt cacgtagcga tagcggagtg tatactggct taactatgcg     4560

gcatcagagc agattgtact gagagtgcac catatatgcg gtgtgaaata ccgcacagat     4620

gcgtaaggag aaaataccgc atcaggcgct cttccgcttc ctcgctcact gactcgctgc     4680

gctcggtcgt tcggctgcgg cgagcggtat cagctcactc aaaggcggta atacggttat     4740

ccacagaatc aggggataac gcaggaaaga acatgtgagc aaaaggccag caaaaggcca     4800

ggaaccgtaa aaaggccgcg ttgctggcgt ttttccatag gctccgcccc cctgacgagc     4860

atcacaaaaa tcgacgctca agtcagaggt ggcgaaaccc gacaggacta taaagatacc     4920

aggcgtttcc ccctggaagc tccctcgtgc gctctcctgt tccgaccctg ccgcttaccg     4980

gatacctgtc cgcctttctc ccttcgggaa gcgtggcgct ttctcatagc tcacgctgta     5040

ggtatctcag ttcggtgtag gtcgttcgct ccaagctggg ctgtgtgcac gaaccccccg     5100

ttcagcccga ccgctgcgcc ttatccggta actatcgtct tgagtccaac ccggtaagac     5160

acgacttatc gccactggca gcagccactg gtaacaggat tagcagagcg aggtatgtag     5220

gcggtgctac agagttcttg aagtggtggc ctaactacgg ctacactaga aggacagtat     5280

ttggtatctg cgctctgctg aagccagtta ccttcggaaa aagagttggt agctcttgat     5340

ccggcaaaca aaccaccgct ggtagcggtg gtttttttgt ttgcaagcag cagattacgc     5400

gcagaaaaaa aggatctcaa gaagatcctt tgatcttttc tacggggtct gacgctcagt     5460

ggaacgaaaa ctcacgttaa gggattttgg tcatgaacaa taaaactgtc tgcttacata     5520

aacagtaata caaggggtgt tatgagccat attcaacggg aaacgtcttg ctctaggccg     5580

cgattaaatt ccaacatgga tgctgattta tatgggtata aatgggctcg cgataatgtc     5640

gggcaatcag gtgcgacaat ctatcgattg tatgggaagc ccgatgcgcc agagttgttt     5700

ctgaaacatg gcaaaggtag cgttgccaat gatgttacag atgagatggt cagactaaac     5760

tggctgacgg aatttatgcc tcttccgacc atcaagcatt ttatccgtac tcctgatgat     5820

gcatggttac tcaccactgc gatccccggg aaaacagcat tccaggtatt agaagaatat     5880

cctgattcag gtgaaaatat tgttgatgcg ctggcagtgt tcctgcgccg gttgcattcg     5940

attcctgttt gtaattgtcc ttttaacagc gatcgcgtat ttcgtctcgc tcaggcgcaa     6000

tcacgaatga ataacggttt ggttgatgcg agtgattttg atgacgagcg taatggctgg     6060

cctgttgaac aagtctggaa agaaatgcat aaacttttgc cattctcacc ggattcagtc     6120

gtcactcatg gtgatttctc acttgataac cttatttttg acgaggggaa attaataggt     6180

tgtattgatg ttggacgagt cggaatcgca gaccgatacc aggatcttgc catcctatgg     6240

aactgcctcg gtgagttttc tccttcatta cagaaacggc tttttcaaaa atatggtatt     6300

gataatcctg atatgaataa attgcagttt catttgatgc tcgatgagtt tttctaagaa     6360

ttaattcatg agcggataca tatttgaatg tatttagaaa aataaacaaa taggggttcc     6420

gcgcacattt ccccgaaaag tgccacctga aattgtaaac gttaatattt tgttaaaatt     6480

cgcgttaaat ttttgttaaa tcagctcatt ttttaaccaa taggccgaaa tcggcaaaat     6540

cccttataaa tcaaaagaat agaccgagat agggttgagt gttgttccag tttggaacaa     6600

gagtccacta ttaaagaacg tggactccaa cgtcaaaggg cgaaaaaccg tctatcaggg     6660

cgatggccca ctacgtgaac catcacccta atcaagtttt ttggggtcga ggtgccgtaa     6720

agcactaaat cggaacccta aagggagccc ccgatttaga gcttgacggg gaaagccggc     6780

gaacgtggcg agaaaggaag ggaagaaagc gaaaggagcg ggcgctaggg cgctggcaag     6840

tgtagcggtc acgctgcgcg taaccaccac acccgccgcg cttaatgcgc cgctacaggg     6900

cgcgtcccat tcgcca                                                     6916


<210>  22
<211>  7257
<212>  DNA
<213>  Synthetic


<220>
<221>  gene
<222>  (1)..(7257)
<223>  Plasmid (pPS23)

<400>  22
ctagatctac ttctaaactg aaacaaattt gagggtaggc ttcattgtct gcccttattt       60

ttttatttag gaaaagtgaa cagactaaag agtgttggct ctattgcttt gagtatgtaa      120

attaggcgtt gctgaattaa ggtatgattt ttgacccctg caggatcatc ttgctgggta      180

catcaaaata cccaaatcct tactctcccc tcaatataca acaaaaaaaa ctttttgatt      240

cactttagtc ataaaaatta gaatttatct accgaaatat tacataaatg taatgtatat      300

attttctgat ttattccgtg tgagccatga ttcataattt ataattcata atttctaaat      360

atgcccctac aatggatata gaatgtcatt ttaattatag gtatcataat cgtggtagtt      420

actccggaaa aaactattga atcaaattca gtctcacctg ctacagatag agtagccgtt      480

attcttatgg gatatggaga ggtggaaagt tatgatgatt ttgccaacta taatgaacaa      540

gccttaaacc tacttacggc aaaatttgcc cctgtgccaa catggttata tccccccctt      600

gctaaattgt tagcggtttt cgatttacat gaatggagtc atcaacacgg caattttgtt      660

tctcctcata atgctatttt cgagcgtcaa agagcaaaaa ttgagcatca gttgcaacac      720

acttggggag aaaaagtcaa agtatttaag gctttcaact tctgtaaacc tcatttaccc      780

tatcaagttt tagagcaggt taaagctgaa ggatttgaga aaattctcat ttatcccctc      840

ttagtagttg attctatctt caccagtgga attgcgatcg agcaaataaa cgaggcgtta      900

gcacaaaaag acaaaaaaga agaccattgg gttaaagcct tacgttatat accttctttc      960

tacaataaac cagagtatat cgatttatta gctaaattag tagaagaaga aatcgacgca     1020

aaattaagca atgcttattt accttcagaa attggtattg ttttaatgaa tcacggttgc     1080

cctcatgaag caaaaggatt tacttcgggt attgatgaaa gtcaagcctt atatgaattg     1140

gtaagagaaa aactcattta tcgttatccc ttaatttccg taggttggct caaccatcaa     1200

acccctctaa ttaaatggac tcaacctaat gcggagttag caggaagaaa cttgattgag     1260

ttaggggcaa aagccttaat atttatgccc attggctttg caacggaaaa ccatgaaacc     1320

ttgttagatg tagaacacat tattcaagca ttatacgtta aatatcccga tgtcaattat     1380

gtccagatgg aatgcgttaa cgataatgaa gaattttgtg ctatggcggc acaatgggtt     1440

aatcctttga ttgaatcctt attaacggaa gaaggggcgc gccacctgca ggcatgcaag     1500

cttggcatcc gcttacagac aagctgtgac cgtctccggg agctgcatgt gtcagaggtt     1560

ttcaccgtca tcaccgaaac gcgcgagacg aaagggcctc gtgatacgcc tatttttata     1620

ggttaatgtc atgataataa tggtttctta gacgtcaggt ggcacttttc ggggaaatgt     1680

gcgcggaacc cctatttgtt tatttttcta aatacattca aatatgtatc cgctcatgag     1740

acaataaccc tgataaatgc ttcaataata ttgaaaaagg aagagtatga gtattcaaca     1800

tttccgtgtc gcccttattc ccttttttgc ggcattttgc cttcctgttt ttgctcaccc     1860

agaaacgctg gtgaaagtaa aagatgctga agatcagttg ggtgcacgag tgggttacat     1920

cgaactggat ctcaacagcg gtaagatcct tgagagtttt cgccccgaag aacgttttcc     1980

aatgatgagc acttttaaag ttctgctatg tggcgcggta ttatcccgta ttgacgccgg     2040

gcaagagcaa ctcggtcgcc gcatacacta ttctcagaat gacttggttg agtactcacc     2100

agtcacagaa aagcatctta cggatggcat gacagtaaga gaattatgca gtgctgccat     2160

aaccatgagt gataacactg cggccaactt acttctgaca acgatcggag gaccgaagga     2220

gctaaccgct tttttgcaca acatggggga tcatgtaact cgccttgatc gttgggaacc     2280

ggagctgaat gaagccatac caaacgacga gcgtgacacc acgatgcctg tagcaatggc     2340

aacaacgttg cgcaaactat taactggcga actacttact ctagcttccc ggcaacaatt     2400

aatagactgg atggaggcgg ataaagttgc aggaccactt ctgcgctcgg cccttccggc     2460

tggctggttt attgctgata aatctggagc cggtgagcgt gggtcttgcg gtatcattgc     2520

agcactgggg ccagatggta agccctcccg tatcgtagtt atctacacga cggggagtca     2580

ggcaactatg gatgaacgaa atagacagat cgctgagata ggtgcctcac tgattaagca     2640

ttggtaactg tcagaccaag tttactcata tatactttag attgatttaa aacttcattt     2700

ttaatttaaa aggatctagg tgaagatcct ttttgataat ctcatgacca aaatccctta     2760

acgtgagttt tcgttccact gagcgtcaga ccccgtagaa aagatcaaag gatcttcttg     2820

agatcctttt tttctgcgcg taatctgctg cttgcaaaca aaaaaaccac cgctaccagc     2880

ggtggtttgt ttgccggatc aagagctacc aactcttttt ccgaaggtaa ctggcttcag     2940

cagagcgcag ataccaaata ctgttcttct agtgtagccg tagttaggcc accacttcaa     3000

gaactctgta gcaccgccta catacctcgc tctgctaatc ctgttaccag tggctgctgc     3060

cagtggcgat aagtcgtgtc ttaccgggtt ggactcaaga cgatagttac cggataaggc     3120

gcagcggtcg ggctgaacgg ggggttcgtg cacacagccc agcttggagc gaacgaccta     3180

caccgaactg agatacctac agcgtgagct atgagaaagc gccacgcttc ccgaagggag     3240

aaaggcggac aggtatccgg taagcggcag ggtcggaaca ggagagcgca cgagggagct     3300

tccaggggga aacgcctggt atctttatag tcctgtcggg tttcgccacc tctgacttga     3360

gcgtcgattt ttgtgatgct cgtcaggggg gcggagccta tggaaaaacg ccagcaacgc     3420

ggccttttta cggttcctgg ccttttgctg gccttttgct cacatgttct ttcctgcgtt     3480

atcccctgat tctgtggata accgtattac cgcctttgag tgagctgata ccgctcgccg     3540

cagccgaacg accgagcgca gcgagtcagt gagcgaggaa gcggaagagc gcccaatacg     3600

caaaccgcct ctccccgcgc gttggccgat tcattaatgc aggaaattcg agctcaaggc     3660

ccaggcggcc gcgtatgtga attcctgatt tggttgacgt agtttttgaa tcgcttttgc     3720

ctgaatttgt ctaactcttt cccttgataa attcataatt gaggcagtat cactaaggga     3780

ataaattttg ccattttcaa acccataacg cagtctcaga attttttgtt ctctttcatt     3840

gagtaaagaa agcatagagc gcaaatcctt ttgcatagat actctcatta agttttcttc     3900

gggagttgca gattctgttt caattaattc cactaattca gtgttataat cttctcccac     3960

tttcatttct aaggatatgg agcggggtat ttgatttaaa aattgacgca aatcaaggga     4020

agtcatatcc atttctttgg ctatttcatc tactgtggcg attctgccca atttttggga     4080

taattgtctc tgtacttttt ttagttgatt taatctttca gtaatatgga taggaagacg     4140

aatggttcta gcttgagttg cgatcgctct tgtcattccc tgacgaatcc accaataagc     4200

ataagtgctg aaatgatagc ctttggtatg atcaaatttt tcaacggctt tttctaaacc     4260

gagagtacct tcttgaatta agtctaataa ttctaatcct ctattttgat attttttggc     4320

aatagagaca actaaacgca aattagcatt aatcattttc tgttttgctt taatgccatt     4380

agccaaaata gtttctaact ctgatagttt gacttgtgct aaattagccc atgtttcttt     4440

tccttctgta attatcgatt ctactttttt cggagttaaa ttgagttgtt gagcgatttt     4500

tcctattttg actgcttcag agtgattcgc taccaaagaa tcaaatattg tcatgatttc     4560

caaatatttt gcaagaactg gcagttccct atttttgtct ctgattgcca ataaattttg     4620

agaggccgta cttcgacaag acctggaaaa gcggaatatt gtcaaccagt tgttaacact     4680

ttcccaccct tccaggccag ctagactagt ttattttcct acaacttttg taatctcccc     4740

cttcacgtag tgaacaaatt cttctaactg atctgctcta gaagctaacc tatcttcctc     4800

ttgtcctaaa taagcttgac gtgcttccaa aattacgggt tgatattgag caggtaatcg     4860

ttccatggcc caatcggctg ccacgtcttt aggagcaatt ttccctgtaa ctgcagaata     4920

ccaaatacga gataaagtaa gtacaacatt tcgttcatca cctgcccagt cggggggact     4980

attccataag gttaaagttt catttaaagc ttcgaataag tcttgctcag ggacagggtc     5040

aaataactct tcggcagcag ggccaactaa ggccacgctg tgttctctgg ctttggtaag     5100

aagaatcgct aaatcaatat caatagtggc aggttcaaaa attcctgcta aaatatcatt     5160

cctttgccat tctccaaatt gtaactcacg cttcgctgga tatctccagg gaataatatc     5220

gtcatgtact actatggtca cttcaactgc ccgaagaatc tcagattccc caggggatgc     5280

acttgtttct aacaaatcat taattaaggc acgacgagtt gtttcatcca ggcgaacggt     5340

gacagttaca agtaaatcta tgtcactgtg aggttttaat cctccatcta cagcagatcc     5400

atataaatgg acagctaata aggtgggttc taaatgacgt tcgattactc ctacaacttc     5460

agagagttgt gtgctaacct cggcaataac ggcttcacgc attattttct ccttttttcg     5520

ggttaatcct ccatctaagg ttgtttaatt tctttggcta gaaacacccg atgccttaga     5580

tgtgcgaatt ttgacaactt ttctagtata tcattgtctt tttttttttt ccagatttac     5640

cccttgtttt attttcttga tggaagttaa gatcttttta gggtcatctc atttaacagt     5700

tagttatagg gaaaattggc gaggtgatct gtcgacaatt aataacttct tcctgtacgg     5760

gcgaatggcc atttgctcct aactaactcc gtactgcttt gcggaacgag cgtagcgaac     5820

tctccgaatt actaagcctt catccctgat agatgcaaaa aacgaattaa aattatgtgt     5880

aaaaagaaaa tgtgtcttta tttagtagtc aaagttacaa aatattaaga atcaaattaa     5940

taatgtattg ggcagttaag tatataagtc tttaaatatt tatttgtatt caatatatta     6000

aggaggatca gccttatgga ttataattta gctttagata ctgctttaaa tagattacat     6060

actgaaggta gatatagaac ttttattgat attgaaagaa gaaaaggtgc ttttcctaaa     6120

gctatgtgga gaaaacctga tggttctgaa aaagaaatta ctgtttggtg tggtaatgat     6180

tatttaggta tgggtcaaca tcctgttgtt ttaggtgcta tgcatgaagc tttagattct     6240

actggtgctg gttctggtgg tactagaaat atttctggta ctactttata tcataaaaga     6300

ttagaagctg aattagctga tttacatggt aaagaagctg ctttagtttt ttcttctgct     6360

tatattgcta atgatgctac tttatctact ttacctcaat taattcctgg tttagttatt     6420

gtttctgata aattaaatca tgcttctatg attgaaggta ttagaagatc tggtactgaa     6480

aaacatattt ttaaacataa tgatttagat gatttaagaa gaattttaac ttctattggt     6540

aaagatagac ctattttagt tgcttttgaa tctgtttatt ctatggatgg tgattttggt     6600

agaattgaag aaatttgtga tattgctgat gaatttggtg ctttaaaata tattgatgaa     6660

gttcatgctg ttggtatgta tggtcctaga ggtggtggtg ttgctgaaag agatggttta     6720

atggatagaa ttgatattat taatggtact ttaggtaaag cttatggtgt ttttggtggt     6780

tatattgctg cttcttctaa aatgtgtgat gctgttagat cttatgctcc tggttttatt     6840

ttttctactt ctttacctcc tgttgttgct gctggtgctg ctgcttctgt tagacattta     6900

aaaggtgatg ttgaattaag agaaaaacat caaactcaag ctagaatttt aaaaatgaga     6960

ttaaaaggtt taggtttacc tattattgat catggttctc atattgttcc tgttcatgtt     7020

ggtgatcctg ttcattgtaa aatgatttct gatatgttat tagaacattt tggtatttat     7080

gttcaaccta ttaattttcc tactgttcct agaggtactg aaagattaag atttactcct     7140

tctcctgttc atgattctgg tatgattgat catttagtta aagctatgga tgttttatgg     7200

caacattgtg ctttaaatag agctgaagtt gttgctcatc atcatcatca tcattga        7257


<210>  23
<211>  9244
<212>  DNA
<213>  Synthetic


<220>
<221>  gene
<222>  (1)..(9244)
<223>  Plasmid (pPSRR24)

<400>  23
atccggatat agttcctcct ttcagcaaaa aacccctcaa gacccgttta gaggccccaa       60

ggggttatgc tagttattgc tcagcggtgg cagcagccaa ctcagcttcc tttcgggctt      120

tgttagcagc cggatcgaat tcttaatggc aatcaccggt ggtgctggct gcgcagcaac      180

tgcttaccga cttgcgggtt gccagcagtt cgatatccac ccggctacgc gcgcggcgca      240

gcagaccgat aaccacgatg ttaaacagga taaccgccag aatgcacacc aggctgtaag      300

ttggatgctg actgtagctg gcgacctgat agaacaatgt tgccagtgag taagcgatat      360

tcagccccca caggatggag aagcccatcc agccacggct tgattcacgg gcgatagccc      420

ccatcaccga gatacatggt acatacagca ggacgaaaat caggtagctg taagctgctg      480

ctgcgctacc gaatttctga tccatcacgc ccatcgcccc ggtacccatt tcgccgtcgc      540

ctttgctggc ttcaatgggg ttcatcagta cgctaaggct gaaggtgtct ttcaggctct      600

gccaggtttc atctatcgca ctgaacagct cttcaccgag gttaaattct gccggattga      660

actcttcgtc ctgaatattt tctgcggtgt agagggtgtt gagcgtaccc actaccactt      720

ctttcgccat ggcacctgta aacaggccaa ccgttgcctg ccagttatct tcatgcacgc      780

caattggctt gaagaccggg gtgatcaccc ggctgacgga cgccagcgcc gagtcgttga      840

tgttatcgac gattttcccg ctcagcgaga agctgttgaa agcgctcagg aaaatgctga      900

cgatgatgat cactttacca gcacgcagaa cgaagccttt cagacgctgc caggtctgga      960

taatcaggct tttaacgtgt ggtacatgat agaccggcaa ctccatgaca aacggcgtcg     1020

cttcaccgcg catgatggtg tacttgagca tcaggccagt cagcaccgcc atcacaatac     1080

ccagcatata cagcgagaag accgccagcg caccgttctg cccgaagaag gcagccgcga     1140

atactgcgaa gatagccaga cgcgcgccgc aggacataaa cggtgccatc atgatggtca     1200

tcagacgttc acgcggtgca tcaagcgtac gtgcacccat taccgacggt acgttacaac     1260

cgaaaccgac gatcagcggc acaaaggatt tccccggcaa gcccagcgcc tgcatcagac     1320

ggtccatcac aaacgccgca cgcgccatat acccggagtc ctcaaggaag gagaggaaca     1380

ggtacatcat gccaatctgc ggcaccagtg gcagcacggt gttaatgccg ccacccaggc     1440

cctgggcgag gaagatagtc agccagtccg ggaagtggag cgtgtagcca atccattgaa     1500

taccatgcac aaatagcgcc acggagccga cgtcaaacag cggctgtaac gccccgccga     1560

tgttgatagc cagcaggaac atcaggtaca tcacaaagag gaaaatcggc agaccgagga     1620

aacggttgag cacgatttta tctaccgcag tggtgaaacg gctgggttct gccgtcaggg     1680

tgttgcttac cacatcacag atggcagcaa tgcactggta acgcgcatcg gcaatgtgca     1740

gcgccggatc gtccatctca ttacgcagac gggcgagggc ggcatccaga tgctgcgacg     1800

cttcaccggc gtaggcgcgg ctgtagatat cgccttccag catttgcagg cccagccagc     1860

gacgttgttt cagcgggatg tcggaaggca tcacttttgc cagtgaatct gcttcgttga     1920

gcagcggctg tgcgtaatgc accagttcca cattctcgtt agctttatag cgatcaatcg     1980

ccagcttgag cgcttcaata ccgcgaccac gggttgaaac cagcgggatc accggacagc     2040

ccagacgcgc cgacagagca tcaatttcaa tacgaatatt ttgcttctcg gcaatgtcga     2100

gcatgttcag tgccacaatg cagggaatgc cgagttccag cagttgtagc gtcaggtaca     2160

ggttacgctc aaggttagac gcatccacca cgttaatcag caggtcggcg tcgccactca     2220

aaatgtagtg acaggcgatt tgctcatcga gcgaggtctg cgatgagatg gtggtcagag     2280

aataggtgcc gggcaggtcc accagcgtga cctgatgatc ggtggtggag aattgccctt     2340

ctttacgttc gacggtaacg ccagcccagt tacctacacg ctgacgtgag ccagtgagct     2400

ggttaaataa cgttgtcttg ccagaatttg gattaccaat taagccaatg gttaattttt     2460

tcatggtata tctcctaagc tttcactcga gagccactac ctcggcacga ttaagagcac     2520

agtgctgcca taagacgtcc attgctttaa ctaagtgatc gatcatccca gagtcgtgaa     2580

caggtgaagg agtgaaacgc aagcgctcgg ttccacgagg aactgtcggg aagttgatag     2640

gctgtacata aatgccgaag tgttccagca gcatgtcaga aatcatcttg cagtggaccg     2700

gatcgccgac gtgtacaggg acgatatgag acccgtgatc aataataggc agacccaatc     2760

ccttcaaacg catctttaaa atacgcgcct gtgtctggtg cttctcacgt aattctacgt     2820

cacccttcag gtggcgaacg gaagcagcgg ccccagcggc gaccaccggc ggcagagaag     2880

tggagaaaat aaatcccgga gcatatgagc gtaccgcatc acacatctta gaagaggcgg     2940

caatataccc tccgaaaact ccgtaggctt tacccagcgt gccgttaata atgtcgatgc     3000

ggtccatcag tccgtcacgt tcagcaacac caccaccgcg cggtccatac attcccaccg     3060

cgtgtacttc atcaatgtac tttaatgctc caaattcatc tgcgatgtcg caaatttcct     3120

caatgcgtcc gaagtcaccg tccatactat atacactctc gaacgcaacc aaaattgggc     3180

gatccttccc aatgctggta agaatgcggc gcaaatcatc caggtcatta tgtttgaaga     3240

tgtgtttttc agttcccgag cggcggatcc cttcgatcat actagcatga ttcagcttgt     3300

cggagacaat gacaagtccg ggaataagtt gaggcaacgt agacaacgta gcgtcgtttg     3360

cgatgtatgc tgagctaaag actaacgctg cttccttccc atgtaaatct gccagttctg     3420

cttccagacg tttatgatat aatgttgtgc cggagatatt gcgggtaccc ccagaccccg     3480

cacctgtcga gtcaagtgcc tcgtgcattg ctccaagaac taccgggtgc tgtcccatcc     3540

ccaagtaatc gttgccgcac cagaccgtaa tctctttctc agatccatcc ggcttacgcc     3600

acatagcctt cgggaaagcg cccttgcggc gttcgatgtc gatgaatgtg cgataacgcc     3660

cttcagtgtg taaacggttc aatgcagtat ctaatgccaa gttataatcc atggtatatc     3720

tccttcttaa agtctcgagc tatcggttta aaacatcatt tcgatgggat agagccccga     3780

caatcgcccc aacttcgtca attaaatttt gttcgatacc taactctttg agagtattga     3840

tcaaattttc tgcgatcgca tcaaaatgaa catccgttaa acccatatta tctactaaat     3900

gtttatggga ttctcgcata tctctaccag aaaaagtatc aggacctcca aaagcataag     3960

tcataaaagc cttttgatga gctttttgtt tcttcatatc cgtattggca aagaaataat     4020

taactcggtc atcctttaac accttatcat agaacttatc gactgcaata tctacagctt     4080

ctttaccgcc taatttttcg tacaaactac tcatatggct gccgcgcggc accaggccgc     4140

tgctgtgatg atgatgatga tggctgctgc ccatggtata tctccttctt aaagttaaac     4200

aaaattattt ctagagggga attgttatcc gctcacaatt cccctatagt gagtcgtatt     4260

aatttcgcgg gatcgagatc tcgatcctct acgccggacg catcgtggcc ggcatcaccg     4320

gcgccacagg tgcggttgct ggcgcctata tcgccgacat caccgatggg gaagatcggg     4380

ctcgccactt cgggctcatg agcgcttgtt tcggcgtggg tatggtggca ggccccgtgg     4440

ccgggggact gttgggcgcc atctccttgc atgcaccatt ccttgcggcg gcggtgctca     4500

acggcctcaa cctactactg ggctgcttcc taatgcagga gtcgcataag ggagagcgtc     4560

gagatcccgg acaccatcga atggcgcaaa acctttcgcg gtatggcatg atagcgcccg     4620

gaagagagtc aattcagggt ggtgaatgtg aaaccagtaa cgttatacga tgtcgcagag     4680

tatgccggtg tctcttatca gaccgtttcc cgcgtggtga accaggccag ccacgtttct     4740

gcgaaaacgc gggaaaaagt ggaagcggcg atggcggagc tgaattacat tcccaaccgc     4800

gtggcacaac aactggcggg caaacagtcg ttgctgattg gcgttgccac ctccagtctg     4860

gccctgcacg cgccgtcgca aattgtcgcg gcgattaaat ctcgcgccga tcaactgggt     4920

gccagcgtgg tggtgtcgat ggtagaacga agcggcgtcg aagcctgtaa agcggcggtg     4980

cacaatcttc tcgcgcaacg cgtcagtggg ctgatcatta actatccgct ggatgaccag     5040

gatgccattg ctgtggaagc tgcctgcact aatgttccgg cgttatttct tgatgtctct     5100

gaccagacac ccatcaacag tattattttc tcccatgaag acggtacgcg actgggcgtg     5160

gagcatctgg tcgcattggg tcaccagcaa atcgcgctgt tagcgggccc attaagttct     5220

gtctcggcgc gtctgcgtct ggctggctgg cataaatatc tcactcgcaa tcaaattcag     5280

ccgatagcgg aacgggaagg cgactggagt gccatgtccg gttttcaaca aaccatgcaa     5340

atgctgaatg agggcatcgt tcccactgcg atgctggttg ccaacgatca gatggcgctg     5400

ggcgcaatgc gcgccattac cgagtccggg ctgcgcgttg gtgcggatat ctcggtagtg     5460

ggatacgacg ataccgaaga cagctcatgt tatatcccgc cgttaaccac catcaaacag     5520

gattttcgcc tgctggggca aaccagcgtg gaccgcttgc tgcaactctc tcagggccag     5580

gcggtgaagg gcaatcagct gttgcccgtc tcactggtga aaagaaaaac caccctggcg     5640

cccaatacgc aaaccgcctc tccccgcgcg ttggccgatt cattaatgca gctggcacga     5700

caggtttccc gactggaaag cgggcagtga gcgcaacgca attaatgtaa gttagctcac     5760

tcattaggca ccgggatctc gaccgatgcc cttgagagcc ttcaacccag tcagctcctt     5820

ccggtgggcg cggggcatga ctatcgtcgc cgcacttatg actgtcttct ttatcatgca     5880

actcgtagga caggtgccgg cagcgctctg ggtcattttc ggcgaggacc gctttcgctg     5940

gagcgcgacg atgatcggcc tgtcgcttgc ggtattcgga atcttgcacg ccctcgctca     6000

agccttcgtc actggtcccg ccaccaaacg tttcggcgag aagcaggcca ttatcgccgg     6060

catggcggcc ccacgggtgc gcatgatcgt gctcctgtcg ttgaggaccc ggctaggctg     6120

gcggggttgc cttactggtt agcagaatga atcaccgata cgcgagcgaa cgtgaagcga     6180

ctgctgctgc aaaacgtctg cgacctgagc aacaacatga atggtcttcg gtttccgtgt     6240

ttcgtaaagt ctggaaacgc ggaagtcagc gccctgcacc attatgttcc ggatctgcat     6300

cgcaggatgc tgctggctac cctgtggaac acctacatct gtattaacga agcgctggca     6360

ttgaccctga gtgatttttc tctggtcccg ccgcatccat accgccagtt gtttaccctc     6420

acaacgttcc agtaaccggg catgttcatc atcagtaacc cgtatcgtga gcatcctctc     6480

tcgtttcatc ggtatcatta cccccatgaa cagaaatccc ccttacacgg aggcatcagt     6540

gaccaaacag gaaaaaaccg cccttaacat ggcccgcttt atcagaagcc agacattaac     6600

gcttctggag aaactcaacg agctggacgc ggatgaacag gcagacatct gtgaatcgct     6660

tcacgaccac gctgatgagc tttaccgcag ctgcctcgcg cgtttcggtg atgacggtga     6720

aaacctctga cacatgcagc tcccggagac ggtcacagct tgtctgtaag cggatgccgg     6780

gagcagacaa gcccgtcagg gcgcgtcagc gggtgttggc gggtgtcggg gcgcagccat     6840

gacccagtca cgtagcgata gcggagtgta tactggctta actatgcggc atcagagcag     6900

attgtactga gagtgcacca tatatgcggt gtgaaatacc gcacagatgc gtaaggagaa     6960

aataccgcat caggcgctct tccgcttcct cgctcactga ctcgctgcgc tcggtcgttc     7020

ggctgcggcg agcggtatca gctcactcaa aggcggtaat acggttatcc acagaatcag     7080

gggataacgc aggaaagaac atgtgagcaa aaggccagca aaaggccagg aaccgtaaaa     7140

aggccgcgtt gctggcgttt ttccataggc tccgcccccc tgacgagcat cacaaaaatc     7200

gacgctcaag tcagaggtgg cgaaacccga caggactata aagataccag gcgtttcccc     7260

ctggaagctc cctcgtgcgc tctcctgttc cgaccctgcc gcttaccgga tacctgtccg     7320

cctttctccc ttcgggaagc gtggcgcttt ctcatagctc acgctgtagg tatctcagtt     7380

cggtgtaggt cgttcgctcc aagctgggct gtgtgcacga accccccgtt cagcccgacc     7440

gctgcgcctt atccggtaac tatcgtcttg agtccaaccc ggtaagacac gacttatcgc     7500

cactggcagc agccactggt aacaggatta gcagagcgag gtatgtaggc ggtgctacag     7560

agttcttgaa gtggtggcct aactacggct acactagaag gacagtattt ggtatctgcg     7620

ctctgctgaa gccagttacc ttcggaaaaa gagttggtag ctcttgatcc ggcaaacaaa     7680

ccaccgctgg tagcggtggt ttttttgttt gcaagcagca gattacgcgc agaaaaaaag     7740

gatctcaaga agatcctttg atcttttcta cggggtctga cgctcagtgg aacgaaaact     7800

cacgttaagg gattttggtc atgaacaata aaactgtctg cttacataaa cagtaataca     7860

aggggtgtta tgagccatat tcaacgggaa acgtcttgct ctaggccgcg attaaattcc     7920

aacatggatg ctgatttata tgggtataaa tgggctcgcg ataatgtcgg gcaatcaggt     7980

gcgacaatct atcgattgta tgggaagccc gatgcgccag agttgtttct gaaacatggc     8040

aaaggtagcg ttgccaatga tgttacagat gagatggtca gactaaactg gctgacggaa     8100

tttatgcctc ttccgaccat caagcatttt atccgtactc ctgatgatgc atggttactc     8160

accactgcga tccccgggaa aacagcattc caggtattag aagaatatcc tgattcaggt     8220

gaaaatattg ttgatgcgct ggcagtgttc ctgcgccggt tgcattcgat tcctgtttgt     8280

aattgtcctt ttaacagcga tcgcgtattt cgtctcgctc aggcgcaatc acgaatgaat     8340

aacggtttgg ttgatgcgag tgattttgat gacgagcgta atggctggcc tgttgaacaa     8400

gtctggaaag aaatgcataa acttttgcca ttctcaccgg attcagtcgt cactcatggt     8460

gatttctcac ttgataacct tatttttgac gaggggaaat taataggttg tattgatgtt     8520

ggacgagtcg gaatcgcaga ccgataccag gatcttgcca tcctatggaa ctgcctcggt     8580

gagttttctc cttcattaca gaaacggctt tttcaaaaat atggtattga taatcctgat     8640

atgaataaat tgcagtttca tttgatgctc gatgagtttt tctaagaatt aattcatgag     8700

cggatacata tttgaatgta tttagaaaaa taaacaaata ggggttccgc gcacatttcc     8760

ccgaaaagtg ccacctgaaa ttgtaaacgt taatattttg ttaaaattcg cgttaaattt     8820

ttgttaaatc agctcatttt ttaaccaata ggccgaaatc ggcaaaatcc cttataaatc     8880

aaaagaatag accgagatag ggttgagtgt tgttccagtt tggaacaaga gtccactatt     8940

aaagaacgtg gactccaacg tcaaagggcg aaaaaccgtc tatcagggcg atggcccact     9000

acgtgaacca tcaccctaat caagtttttt ggggtcgagg tgccgtaaag cactaaatcg     9060

gaaccctaaa gggagccccc gatttagagc ttgacgggga aagccggcga acgtggcgag     9120

aaaggaaggg aagaaagcga aaggagcggg cgctagggcg ctggcaagtg tagcggtcac     9180

gctgcgcgta accaccacac ccgccgcgct taatgcgccg ctacagggcg cgtcccattc     9240

gcca                                                                  9244


