                         SEQUENCE LISTING

<110>  West Virginia University
 
<120>  Cross-Protective Antigen for Vaccination

<130>  WVU 3059-PROV

<160>  17    

<170>  PatentIn version 3.5

<210>  1
<211>  1053
<212>  DNA
<213>  Pseudomonas aeruginosa

<400>  1
atgaaactga agaacacctt aggcgttgtc atcggctcgc tggttgccgc ttcggcaatg       60

aacgcctttg cccagggcca gaactcggta gagatcgaag ccttcggcaa gcgctacttc      120

accgacagcg ttcgcaacat gaagaacgcg gacctgtacg gcggctcgat cggttacttc      180

ctgaccgacg acgtcgagct ggcgctgtcc tacggtgagt accatgacgt tcgtggcacc      240

tacgaaaccg gcaacaagaa ggtccacggc aacctgacct ccctggacgc catctaccac      300

ttcggtaccc cgggcgtagg tctgcgtccg tacgtgtcgg ctggtctggc tcaccagaac      360

atcaccaaca tcaacagcga cagccaaggc cgtcagcaga tgaccatggc caacatcggc      420

gctggtctga agtactactt caccgagaac ttcttcgcca aggccagcct cgacggccag      480

tacggtctgg agaagcgtga caacggtcac cagggcgagt ggatggctgg cctgggcgtc      540

ggcttcaact tcggtggttc gaaagccgct ccggctccgg aaccggttgc cgacgtttgc      600

tccgactccg acaacgacgg cgtttgcgac aacgtcgaca agtgcccgga taccccggcc      660

aacgtcaccg ttgacgccaa cggctgcccg gctgtcgccg aagtcgtacg cgtacagctg      720

gacgtgaagt tcgacttcga caagtccaag gtcaaagaga acagctacgc tgacatcaag      780

aacctggctg acttcatgaa gcagtacccg tccacttcca ccaccgttga aggtcacacc      840

gactccgtcg gcaccgacgc ttacaaccag aagctgtccg agcgtcgtgc caacgccgtt      900

cgtgacgtac tggtcaacga gtacggtgta gaaggtggtc gcgtgaacgc tgttggttac      960

ggcgagtccc gcccggttgc cgacaacgcc accgctgaag gccgcgctat caaccgtcgc     1020

gttgaagccg aagtagaagc tgaagccaag taa                                  1053


<210>  2
<211>  350
<212>  PRT
<213>  Pseudomonas aeruginosa

<400>  2

Met Lys Leu Lys Asn Thr Leu Gly Val Val Ile Gly Ser Leu Val Ala 
1               5                   10                  15      


Ala Ser Ala Met Asn Ala Phe Ala Gln Gly Gln Asn Ser Val Glu Ile 
            20                  25                  30          


Glu Ala Phe Gly Lys Arg Tyr Phe Thr Asp Ser Val Arg Asn Met Lys 
        35                  40                  45              


Asn Ala Asp Leu Tyr Gly Gly Ser Ile Gly Tyr Phe Leu Thr Asp Asp 
    50                  55                  60                  


Val Glu Leu Ala Leu Ser Tyr Gly Glu Tyr His Asp Val Arg Gly Thr 
65                  70                  75                  80  


Tyr Glu Thr Gly Asn Lys Lys Val His Gly Asn Leu Thr Ser Leu Asp 
                85                  90                  95      


Ala Ile Tyr His Phe Gly Thr Pro Gly Val Gly Leu Arg Pro Tyr Val 
            100                 105                 110         


Ser Ala Gly Leu Ala His Gln Asn Ile Thr Asn Ile Asn Ser Asp Ser 
        115                 120                 125             


Gln Gly Arg Gln Gln Met Thr Met Ala Asn Ile Gly Ala Gly Leu Lys 
    130                 135                 140                 


Tyr Tyr Phe Thr Glu Asn Phe Phe Ala Lys Ala Ser Leu Asp Gly Gln 
145                 150                 155                 160 


Tyr Gly Leu Glu Lys Arg Asp Asn Gly His Gln Gly Glu Trp Met Ala 
                165                 170                 175     


Gly Leu Gly Val Gly Phe Asn Phe Gly Gly Ser Lys Ala Ala Pro Ala 
            180                 185                 190         


Pro Glu Pro Val Ala Asp Val Cys Ser Asp Ser Asp Asn Asp Gly Val 
        195                 200                 205             


Cys Asp Asn Val Asp Lys Cys Pro Asp Thr Pro Ala Asn Val Thr Val 
    210                 215                 220                 


Asp Ala Asn Gly Cys Pro Ala Val Ala Glu Val Val Arg Val Gln Leu 
225                 230                 235                 240 


Asp Val Lys Phe Asp Phe Asp Lys Ser Lys Val Lys Glu Asn Ser Tyr 
                245                 250                 255     


Ala Asp Ile Lys Asn Leu Ala Asp Phe Met Lys Gln Tyr Pro Ser Thr 
            260                 265                 270         


Ser Thr Thr Val Glu Gly His Thr Asp Ser Val Gly Thr Asp Ala Tyr 
        275                 280                 285             


Asn Gln Lys Leu Ser Glu Arg Arg Ala Asn Ala Val Arg Asp Val Leu 
    290                 295                 300                 


Val Asn Glu Tyr Gly Val Glu Gly Gly Arg Val Asn Ala Val Gly Tyr 
305                 310                 315                 320 


Gly Glu Ser Arg Pro Val Ala Asp Asn Ala Thr Ala Glu Gly Arg Ala 
                325                 330                 335     


Ile Asn Arg Arg Val Glu Ala Glu Val Glu Ala Glu Ala Lys 
            340                 345                 350 


<210>  3
<211>  120
<212>  PRT
<213>  Pseudomonas aeruginosa

<400>  3

Ala Val Ala Glu Val Val Arg Val Gln Leu Asp Val Lys Phe Asp Phe 
1               5                   10                  15      


Asp Lys Ser Lys Val Lys Glu Asn Ser Tyr Ala Asp Ile Lys Asn Leu 
            20                  25                  30          


Ala Asp Phe Met Lys Gln Tyr Pro Ser Thr Ser Thr Thr Val Glu Gly 
        35                  40                  45              


His Thr Asp Ser Val Gly Thr Asp Ala Tyr Asn Gln Lys Leu Ser Glu 
    50                  55                  60                  


Arg Arg Ala Asn Ala Val Arg Asp Val Leu Val Asn Glu Tyr Gly Val 
65                  70                  75                  80  


Glu Gly Gly Arg Val Asn Ala Val Gly Tyr Gly Glu Ser Arg Pro Val 
                85                  90                  95      


Ala Asp Asn Ala Thr Ala Glu Gly Arg Ala Ile Asn Arg Arg Val Glu 
            100                 105                 110         


Ala Glu Val Glu Ala Glu Ala Lys 
        115                 120 


<210>  4
<211>  24
<212>  PRT
<213>  Pseudomonas aeruginosa

<400>  4

Gly His Thr Asp Ser Val Gly Thr Asp Ala Tyr Asn Gln Lys Leu Ser 
1               5                   10                  15      


Glu Arg Arg Ala Asn Ala Val Arg 
            20                  


<210>  5
<211>  17
<212>  PRT
<213>  Pseudomonas aeruginosa

<400>  5

Asp Asn Ala Thr Ala Glu Gly Arg Ala Ile Asn Arg Arg Val Glu Ala 
1               5                   10                  15      


Glu 
    


<210>  6
<211>  67
<212>  PRT
<213>  Pseudomonas aeruginosa

<400>  6

Gly His Thr Asp Ser Val Gly Thr Asp Ala Tyr Asn Gln Lys Leu Ser 
1               5                   10                  15      


Glu Arg Arg Ala Asn Ala Val Arg Asp Val Leu Val Asn Glu Tyr Gly 
            20                  25                  30          


Val Glu Gly Gly Arg Val Asn Ala Val Gly Tyr Gly Glu Ser Arg Pro 
        35                  40                  45              


Val Ala Asp Asn Ala Thr Ala Glu Gly Arg Ala Ile Asn Arg Arg Val 
    50                  55                  60                  


Glu Ala Glu 
65          


<210>  7
<211>  582
<212>  DNA
<213>  Bordetella pertussis

<400>  7
atgaacaaac cctccaaatt cgctctggcg ctcgccttcg ccgctgttac ggcctctggt       60

gcagcttccg cgcaaaccgt ggacaactgg cgcaatccgt ttggcgacgt ttggaagaac      120

ggcaccaatg aactgtgctg gcgcgatgcg ttctggaccc cggctaccgg catccccggt      180

tgcgacggcg ttccggtcgc tcagaaggaa aagtccgctc ccatggccgc caaggtcgtg      240

ttcaatgctg acaccttctt cgacttcgac aagtcgacgc tgaagccgga aggccgccag      300

ctgctggatc aagtcgccca gcaagccggc acgatcgatc tggaaacgat catcgccgtt      360

ggccacacgg actcgatcgg caccgaagcc tacaaccaga agctgtccga gcgccgtgcc      420

gctgcggtca agacctacct ggtcagcaag ggtatcgacc ccaaccgtat ctacacggaa      480

ggcaagggcg aactgcaacc gatcgcttcg aacaagacgc gtgaaggccg tgcccagaac      540

cgtcgcgtgg aaatcgaaat cgtcggtagc cgcaagaact aa                         582


<210>  8
<211>  193
<212>  PRT
<213>  Bordetella pertussis

<400>  8

Met Asn Lys Pro Ser Lys Phe Ala Leu Ala Leu Ala Phe Ala Ala Val 
1               5                   10                  15      


Thr Ala Ser Gly Ala Ala Ser Ala Gln Thr Val Asp Asn Trp Arg Asn 
            20                  25                  30          


Pro Phe Gly Asp Val Trp Lys Asn Gly Thr Asn Glu Leu Cys Trp Arg 
        35                  40                  45              


Asp Ala Phe Trp Thr Pro Ala Thr Gly Ile Pro Gly Cys Asp Gly Val 
    50                  55                  60                  


Pro Val Ala Gln Lys Glu Lys Ser Ala Pro Met Ala Ala Lys Val Val 
65                  70                  75                  80  


Phe Asn Ala Asp Thr Phe Phe Asp Phe Asp Lys Ser Thr Leu Lys Pro 
                85                  90                  95      


Glu Gly Arg Gln Leu Leu Asp Gln Val Ala Gln Gln Ala Gly Thr Ile 
            100                 105                 110         


Asp Leu Glu Thr Ile Ile Ala Val Gly His Thr Asp Ser Ile Gly Thr 
        115                 120                 125             


Glu Ala Tyr Asn Gln Lys Leu Ser Glu Arg Arg Ala Ala Ala Val Lys 
    130                 135                 140                 


Thr Tyr Leu Val Ser Lys Gly Ile Asp Pro Asn Arg Ile Tyr Thr Glu 
145                 150                 155                 160 


Gly Lys Gly Glu Leu Gln Pro Ile Ala Ser Asn Lys Thr Arg Glu Gly 
                165                 170                 175     


Arg Ala Gln Asn Arg Arg Val Glu Ile Glu Ile Val Gly Ser Arg Lys 
            180                 185                 190         


Asn 
    


<210>  9
<211>  120
<212>  PRT
<213>  Bordetella pertussis

<400>  9

Pro Met Ala Ala Lys Val Val Phe Asn Ala Asp Thr Phe Phe Asp Phe 
1               5                   10                  15      


Asp Lys Ser Thr Leu Lys Pro Glu Gly Arg Gln Leu Leu Asp Gln Val 
            20                  25                  30          


Ala Gln Gln Ala Gly Thr Ile Asp Leu Glu Thr Ile Ile Ala Val Gly 
        35                  40                  45              


His Thr Asp Ser Ile Gly Thr Glu Ala Tyr Asn Gln Lys Leu Ser Glu 
    50                  55                  60                  


Arg Arg Ala Ala Ala Val Lys Thr Tyr Leu Val Ser Lys Gly Ile Asp 
65                  70                  75                  80  


Pro Asn Arg Ile Tyr Thr Glu Gly Lys Gly Glu Leu Gln Pro Ile Ala 
                85                  90                  95      


Ser Asn Lys Thr Arg Glu Gly Arg Ala Gln Asn Arg Arg Val Glu Ile 
            100                 105                 110         


Glu Ile Val Gly Ser Arg Lys Asn 
        115                 120 


<210>  10
<211>  25
<212>  PRT
<213>  Bordetella pertussis

<400>  10

Gly His Thr Asp Ser Ile Gly Thr Glu Ala Tyr Asn Gln Lys Leu Ser 
1               5                   10                  15      


Glu Arg Arg Ala Ala Ala Val Lys Thr 
            20                  25  


<210>  11
<211>  17
<212>  PRT
<213>  Bordetella pertussis

<400>  11

Ser Asn Lys Thr Arg Glu Gly Arg Ala Gln Asn Arg Arg Val Glu Ile 
1               5                   10                  15      


Glu 
    


<210>  12
<211>  66
<212>  PRT
<213>  Bordetella pertussis

<400>  12

Gly His Thr Asp Ser Ile Gly Thr Glu Ala Tyr Asn Gln Lys Leu Ser 
1               5                   10                  15      


Glu Arg Arg Ala Ala Ala Val Lys Thr Tyr Leu Val Ser Lys Gly Ile 
            20                  25                  30          


Asp Pro Asn Arg Ile Tyr Thr Glu Gly Lys Gly Glu Leu Gln Pro Ile 
        35                  40                  45              


Ala Ser Asn Lys Thr Arg Glu Gly Arg Ala Gln Asn Arg Arg Val Glu 
    50                  55                  60                  


Ile Glu 
65      


<210>  13
<211>  1644
<212>  DNA
<213>  Pseudomonas aeruginosa

<400>  13
atggctgcca aagaagttaa gttcggcgat tccgctcgca agaaaatgct ggtcggcgtg       60

aacgtgctgg ccgatgccgt caaggccacc ctcggcccga aaggccgcaa cgtggttctg      120

gacaagtcct tcggcgctcc gaccatcacc aaggacggcg tttccgtcgc caaggaaatc      180

gagctgaaag acaagttcga gaacatgggc gcgcaactgg tgaaagacgt tgcctccaag      240

gccaacgacg ctgccggtga cggcaccacc accgcgaccg tcctggccca ggccatcgtc      300

aacgaaggcc tgaaggccgt tgccgccggc atgaacccga tggacctgaa gcgtggcatc      360

gacaaggcca ccgtggctat cgtcgcccag ctgaaagagc tggccaagcc ctgcgccgac      420

accaaggcca tcgcccaggt aggcaccatc tccgccaact ccgacgagtc catcggccag      480

atcattgccg aagccatgga aaaagtcggt aaagaaggcg tgatcaccgt cgaggaaggc      540

tcgggcctgg aaaacgaact gtccgtcgtc gaaggcatgc agttcgatcg cggctacctg      600

tccccctact tcgtgaacaa gccggacacc atggctgccg agctggatag cccgctgctg      660

ctgctggtcg acaagaagat ctccaacatc cgcgaaatgc tgccggtgct ggaagccgtc      720

gccaaggccg gccgtccgct gctgatcgtc gccgaggacg tcgagggcga agccctggcc      780

accctggtgg tgaacaacat gcgtggcatc gtcaaggtcg cggctgtcaa ggctccgggc      840

ttcggcgatc gccgcaaggc catgctgcag gacatcgcca tcctcaccgg cggtaccgtg      900

atcagcgaag aagtcggcct gagcctggaa ggcgctaccc tggagcacct gggcaacgcc      960

aagcgcgtcg tgatcaacaa ggaaaacacc accatcatcg atggcgccgg tgtgcaggct     1020

gatatcgaag cccgcgtcct gcagatccgc aagcagatcg aggaaaccac ttccgactac     1080

gaccgcgaga agctgcaaga gcgcctggcc aagctggccg gcggtgttgc cgtgatcaag     1140

gtaggcgctg ccaccgaagt cgagatgaaa gagaagaaag cccgcgtcga agacgccctg     1200

cacgctaccc gtgcagcggt ggaagagggc gtggttcccg gcggcggcgt agccctggtt     1260

cgtgccctgc aagccatcga aggcctgaag ggtgacaacg aggagcagaa cgtcggtatc     1320

gccctgctgc gtcgcgccgt cgaatcgccg ctgcgccaga tcgtggccaa cgccggcgac     1380

gagccgagcg tagtggtcga caaggtcaag cagggttccg gcaactacgg cttcaacgct     1440

gctaccggcg tgtacggcga catgatcgag atgggcatcc tggacccggc caaggtcact     1500

cgttccgctc tgcaggctgc ggcctccatc ggcggtctga tgatcaccac cgaagccatg     1560

gttgccgaga tcgtggaaga caagccggcc atgggcggca tgcctgacat gggcggcatg     1620

ggcggcatgg gcggcatgat gtaa                                            1644


<210>  14
<211>  547
<212>  PRT
<213>  Pseudomonas aeruginosa

<400>  14

Met Ala Ala Lys Glu Val Lys Phe Gly Asp Ser Ala Arg Lys Lys Met 
1               5                   10                  15      


Leu Val Gly Val Asn Val Leu Ala Asp Ala Val Lys Ala Thr Leu Gly 
            20                  25                  30          


Pro Lys Gly Arg Asn Val Val Leu Asp Lys Ser Phe Gly Ala Pro Thr 
        35                  40                  45              


Ile Thr Lys Asp Gly Val Ser Val Ala Lys Glu Ile Glu Leu Lys Asp 
    50                  55                  60                  


Lys Phe Glu Asn Met Gly Ala Gln Leu Val Lys Asp Val Ala Ser Lys 
65                  70                  75                  80  


Ala Asn Asp Ala Ala Gly Asp Gly Thr Thr Thr Ala Thr Val Leu Ala 
                85                  90                  95      


Gln Ala Ile Val Asn Glu Gly Leu Lys Ala Val Ala Ala Gly Met Asn 
            100                 105                 110         


Pro Met Asp Leu Lys Arg Gly Ile Asp Lys Ala Thr Val Ala Ile Val 
        115                 120                 125             


Ala Gln Leu Lys Glu Leu Ala Lys Pro Cys Ala Asp Thr Lys Ala Ile 
    130                 135                 140                 


Ala Gln Val Gly Thr Ile Ser Ala Asn Ser Asp Glu Ser Ile Gly Gln 
145                 150                 155                 160 


Ile Ile Ala Glu Ala Met Glu Lys Val Gly Lys Glu Gly Val Ile Thr 
                165                 170                 175     


Val Glu Glu Gly Ser Gly Leu Glu Asn Glu Leu Ser Val Val Glu Gly 
            180                 185                 190         


Met Gln Phe Asp Arg Gly Tyr Leu Ser Pro Tyr Phe Val Asn Lys Pro 
        195                 200                 205             


Asp Thr Met Ala Ala Glu Leu Asp Ser Pro Leu Leu Leu Leu Val Asp 
    210                 215                 220                 


Lys Lys Ile Ser Asn Ile Arg Glu Met Leu Pro Val Leu Glu Ala Val 
225                 230                 235                 240 


Ala Lys Ala Gly Arg Pro Leu Leu Ile Val Ala Glu Asp Val Glu Gly 
                245                 250                 255     


Glu Ala Leu Ala Thr Leu Val Val Asn Asn Met Arg Gly Ile Val Lys 
            260                 265                 270         


Val Ala Ala Val Lys Ala Pro Gly Phe Gly Asp Arg Arg Lys Ala Met 
        275                 280                 285             


Leu Gln Asp Ile Ala Ile Leu Thr Gly Gly Thr Val Ile Ser Glu Glu 
    290                 295                 300                 


Val Gly Leu Ser Leu Glu Gly Ala Thr Leu Glu His Leu Gly Asn Ala 
305                 310                 315                 320 


Lys Arg Val Val Ile Asn Lys Glu Asn Thr Thr Ile Ile Asp Gly Ala 
                325                 330                 335     


Gly Val Gln Ala Asp Ile Glu Ala Arg Val Leu Gln Ile Arg Lys Gln 
            340                 345                 350         


Ile Glu Glu Thr Thr Ser Asp Tyr Asp Arg Glu Lys Leu Gln Glu Arg 
        355                 360                 365             


Leu Ala Lys Leu Ala Gly Gly Val Ala Val Ile Lys Val Gly Ala Ala 
    370                 375                 380                 


Thr Glu Val Glu Met Lys Glu Lys Lys Ala Arg Val Glu Asp Ala Leu 
385                 390                 395                 400 


His Ala Thr Arg Ala Ala Val Glu Glu Gly Val Val Pro Gly Gly Gly 
                405                 410                 415     


Val Ala Leu Val Arg Ala Leu Gln Ala Ile Glu Gly Leu Lys Gly Asp 
            420                 425                 430         


Asn Glu Glu Gln Asn Val Gly Ile Ala Leu Leu Arg Arg Ala Val Glu 
        435                 440                 445             


Ser Pro Leu Arg Gln Ile Val Ala Asn Ala Gly Asp Glu Pro Ser Val 
    450                 455                 460                 


Val Val Asp Lys Val Lys Gln Gly Ser Gly Asn Tyr Gly Phe Asn Ala 
465                 470                 475                 480 


Ala Thr Gly Val Tyr Gly Asp Met Ile Glu Met Gly Ile Leu Asp Pro 
                485                 490                 495     


Ala Lys Val Thr Arg Ser Ala Leu Gln Ala Ala Ala Ser Ile Gly Gly 
            500                 505                 510         


Leu Met Ile Thr Thr Glu Ala Met Val Ala Glu Ile Val Glu Asp Lys 
        515                 520                 525             


Pro Ala Met Gly Gly Met Pro Asp Met Gly Gly Met Gly Gly Met Gly 
    530                 535                 540                 


Gly Met Met 
545         


<210>  15
<211>  1644
<212>  DNA
<213>  Bordetella pertussis

<400>  15
atggctgcca agcaagttct gtttgccgac gaagcccgcg tgcgcatcgt gcgcggcgtg       60

aacgtcctcg ccaacgccgt caagaccacc ctgggcccca agggtcgcaa cgtcgtgctg      120

gagcgctcgt tcggcgcccc gacggtgacc aaggacggcg tgtccgtcgc caaggaaatc      180

gaactgaagg acaagttcga gaacatcggc gcccagctgg tcaaggacgt tgcctccaag      240

acctccgaca acgccggtga cggcaccacc accgccaccg tgctggccca ggccgtcgtt      300

caggaaggcc tgaagtacgt cgccgccggc ttcaacccga tcgacctcaa acgcggcatc      360

gacaaggccg tggccgccgc cgtggaagag ctgaagaaac tgtccaagcc ggtcaccacc      420

agcaaggaaa tcgcccaggt tggctcgatc tcggccaaca gcgatgcctc gatcggccag      480

atcatcgctg acgcgatgga caaggtcggc aaggaaggcg tgatcaccgt cgaagacggc      540

aagtcgctgg aaaacgaact ggatgtcgtc gaaggcatgc aattcgaccg cggctacctg      600

tcgccctact tcatcaacag cccggaaaag caagtcgccg cgctggacga tccgtatgtc      660

ctgatctacg acaagaaggt cagcaacatc cgtgacctgc tgcccgtgct ggagcaagtc      720

gccaagtcga gccgtccgct gctgatcatc gccgaagacg tcgaaggcga agcgctggcc      780

accctggtcg tgaacaacat ccgcggcatc ctgaagacca ccgccgtcaa ggccccgggc      840

ttcggcgacc gtcgcaaggc catgctggaa gacatcgcca tcctgacggg cggcacggtg      900

atctccgaag aaaccggcat gtcgctggaa aaggccacgc tgcaggatct gggccaggcc      960

aagcgcatcg aagtggccaa ggaaaacacc acgatcatcg acggcgccgg cgacggcaag     1020

tcgatcgaag cgcgcgtcaa gcagatccgc gcccagatcg aggaagccac ctcggactac     1080

gaccgcgaga agctgcaaga gcgcgtggcc aagctggccg gcggcgttgc cgtgattcgc     1140

gtcggtgctg ccaccgaagt cgaaatgaag gaaaagaagg ctcgcgtcga agacgccctg     1200

cacgccacgc gtgccgcggt ggaagaaggc gtggttcctg gcggtggcgt tgcgctgctg     1260

cgcgccaagc aggccatcac tggcctgaag ggcgacacgg ctgaccagaa cgccggcatc     1320

aagctgatcc tgcgcgctgt cgaagagccc ctgcgcacca tcgtcaccaa cgccggcgac     1380

gaagccagcg tggtggtcaa caccgtgctc aacggcaagg gcaactacgg ctacaacgcc     1440

gcgaccggcg agtacggcga cctggtcgag caaggcgtgc tggacccgac caaggtcacc     1500

cgcaccgcgc tgcagaacgc cgcttcggtg gccagcctgc tgctgacggc cgaagccgcc     1560

gtggtcgagc tgatggaaaa caagcccgct gctgctccgg caatgcccgg cggcatgggc     1620

ggcatgggcg gcatggactt ctaa                                            1644


<210>  16
<211>  547
<212>  PRT
<213>  Bordetella pertussis

<400>  16

Met Ala Ala Lys Gln Val Leu Phe Ala Asp Glu Ala Arg Val Arg Ile 
1               5                   10                  15      


Val Arg Gly Val Asn Val Leu Ala Asn Ala Val Lys Thr Thr Leu Gly 
            20                  25                  30          


Pro Lys Gly Arg Asn Val Val Leu Glu Arg Ser Phe Gly Ala Pro Thr 
        35                  40                  45              


Val Thr Lys Asp Gly Val Ser Val Ala Lys Glu Ile Glu Leu Lys Asp 
    50                  55                  60                  


Lys Phe Glu Asn Ile Gly Ala Gln Leu Val Lys Asp Val Ala Ser Lys 
65                  70                  75                  80  


Thr Ser Asp Asn Ala Gly Asp Gly Thr Thr Thr Ala Thr Val Leu Ala 
                85                  90                  95      


Gln Ala Val Val Gln Glu Gly Leu Lys Tyr Val Ala Ala Gly Phe Asn 
            100                 105                 110         


Pro Ile Asp Leu Lys Arg Gly Ile Asp Lys Ala Val Ala Ala Ala Val 
        115                 120                 125             


Glu Glu Leu Lys Lys Leu Ser Lys Pro Val Thr Thr Ser Lys Glu Ile 
    130                 135                 140                 


Ala Gln Val Gly Ser Ile Ser Ala Asn Ser Asp Ala Ser Ile Gly Gln 
145                 150                 155                 160 


Ile Ile Ala Asp Ala Met Asp Lys Val Gly Lys Glu Gly Val Ile Thr 
                165                 170                 175     


Val Glu Asp Gly Lys Ser Leu Glu Asn Glu Leu Asp Val Val Glu Gly 
            180                 185                 190         


Met Gln Phe Asp Arg Gly Tyr Leu Ser Pro Tyr Phe Ile Asn Ser Pro 
        195                 200                 205             


Glu Lys Gln Val Ala Ala Leu Asp Asp Pro Tyr Val Leu Ile Tyr Asp 
    210                 215                 220                 


Lys Lys Val Ser Asn Ile Arg Asp Leu Leu Pro Val Leu Glu Gln Val 
225                 230                 235                 240 


Ala Lys Ser Ser Arg Pro Leu Leu Ile Ile Ala Glu Asp Val Glu Gly 
                245                 250                 255     


Glu Ala Leu Ala Thr Leu Val Val Asn Asn Ile Arg Gly Ile Leu Lys 
            260                 265                 270         


Thr Thr Ala Val Lys Ala Pro Gly Phe Gly Asp Arg Arg Lys Ala Met 
        275                 280                 285             


Leu Glu Asp Ile Ala Ile Leu Thr Gly Gly Thr Val Ile Ser Glu Glu 
    290                 295                 300                 


Thr Gly Met Ser Leu Glu Lys Ala Thr Leu Gln Asp Leu Gly Gln Ala 
305                 310                 315                 320 


Lys Arg Ile Glu Val Ala Lys Glu Asn Thr Thr Ile Ile Asp Gly Ala 
                325                 330                 335     


Gly Asp Gly Lys Ser Ile Glu Ala Arg Val Lys Gln Ile Arg Ala Gln 
            340                 345                 350         


Ile Glu Glu Ala Thr Ser Asp Tyr Asp Arg Glu Lys Leu Gln Glu Arg 
        355                 360                 365             


Val Ala Lys Leu Ala Gly Gly Val Ala Val Ile Arg Val Gly Ala Ala 
    370                 375                 380                 


Thr Glu Val Glu Met Lys Glu Lys Lys Ala Arg Val Glu Asp Ala Leu 
385                 390                 395                 400 


His Ala Thr Arg Ala Ala Val Glu Glu Gly Val Val Pro Gly Gly Gly 
                405                 410                 415     


Val Ala Leu Leu Arg Ala Lys Gln Ala Ile Thr Gly Leu Lys Gly Asp 
            420                 425                 430         


Thr Ala Asp Gln Asn Ala Gly Ile Lys Leu Ile Leu Arg Ala Val Glu 
        435                 440                 445             


Glu Pro Leu Arg Thr Ile Val Thr Asn Ala Gly Asp Glu Ala Ser Val 
    450                 455                 460                 


Val Val Asn Thr Val Leu Asn Gly Lys Gly Asn Tyr Gly Tyr Asn Ala 
465                 470                 475                 480 


Ala Thr Gly Glu Tyr Gly Asp Leu Val Glu Gln Gly Val Leu Asp Pro 
                485                 490                 495     


Thr Lys Val Thr Arg Thr Ala Leu Gln Asn Ala Ala Ser Val Ala Ser 
            500                 505                 510         


Leu Leu Leu Thr Ala Glu Ala Ala Val Val Glu Leu Met Glu Asn Lys 
        515                 520                 525             


Pro Ala Ala Ala Pro Ala Met Pro Gly Gly Met Gly Gly Met Gly Gly 
    530                 535                 540                 


Met Asp Phe 
545         


<210>  17
<211>  548
<212>  PRT
<213>  Escherichia coli

<400>  17

Met Ala Ala Lys Asp Val Lys Phe Gly Asn Asp Ala Arg Val Lys Met 
1               5                   10                  15      


Leu Arg Gly Val Asn Val Leu Ala Asp Ala Val Lys Val Thr Leu Gly 
            20                  25                  30          


Pro Lys Gly Arg Asn Val Val Leu Asp Lys Ser Phe Gly Ala Pro Thr 
        35                  40                  45              


Ile Thr Lys Asp Gly Val Ser Val Ala Arg Glu Ile Glu Leu Glu Asp 
    50                  55                  60                  


Lys Phe Glu Asn Met Gly Ala Gln Met Val Lys Glu Val Ala Ser Lys 
65                  70                  75                  80  


Ala Asn Asp Ala Ala Gly Asp Gly Thr Thr Thr Ala Thr Val Leu Ala 
                85                  90                  95      


Gln Ala Ile Ile Thr Glu Gly Leu Lys Ala Val Ala Ala Gly Met Asn 
            100                 105                 110         


Pro Met Asp Leu Lys Arg Gly Ile Asp Lys Ala Val Thr Ala Ala Val 
        115                 120                 125             


Glu Glu Leu Lys Ala Leu Ser Val Pro Cys Ser Asp Ser Lys Ala Ile 
    130                 135                 140                 


Ala Gln Val Gly Thr Ile Ser Ala Asn Ser Asp Glu Thr Val Gly Lys 
145                 150                 155                 160 


Leu Ile Ala Glu Ala Met Asp Lys Val Gly Lys Glu Gly Val Ile Thr 
                165                 170                 175     


Val Glu Asp Gly Thr Gly Leu Gln Asp Glu Leu Asp Val Val Glu Gly 
            180                 185                 190         


Met Gln Phe Asp Arg Gly Tyr Leu Ser Pro Tyr Phe Ile Asn Lys Pro 
        195                 200                 205             


Glu Thr Gly Ala Val Glu Leu Glu Ser Pro Phe Ile Leu Leu Ala Asp 
    210                 215                 220                 


Lys Lys Ile Ser Asn Ile Arg Glu Met Leu Pro Val Leu Glu Ala Val 
225                 230                 235                 240 


Ala Lys Ala Gly Lys Pro Leu Leu Ile Ile Ala Glu Asp Val Glu Gly 
                245                 250                 255     


Glu Ala Leu Ala Thr Leu Val Val Asn Thr Met Arg Gly Ile Val Lys 
            260                 265                 270         


Val Ala Ala Val Lys Ala Pro Gly Phe Gly Asp Arg Arg Lys Ala Met 
        275                 280                 285             


Leu Gln Asp Ile Ala Thr Leu Thr Gly Gly Thr Val Ile Ser Glu Glu 
    290                 295                 300                 


Ile Gly Met Glu Leu Glu Lys Ala Thr Leu Glu Asp Leu Gly Gln Ala 
305                 310                 315                 320 


Lys Arg Val Val Ile Asn Lys Asp Thr Thr Thr Ile Ile Asp Gly Val 
                325                 330                 335     


Gly Glu Glu Ala Ala Ile Gln Gly Arg Val Ala Gln Ile Arg Gln Gln 
            340                 345                 350         


Ile Glu Glu Ala Thr Ser Asp Tyr Asp Arg Glu Lys Leu Gln Glu Arg 
        355                 360                 365             


Val Ala Lys Leu Ala Gly Gly Val Ala Val Ile Lys Val Gly Ala Ala 
    370                 375                 380                 


Thr Glu Val Glu Met Lys Glu Lys Lys Ala Arg Val Glu Asp Ala Leu 
385                 390                 395                 400 


His Ala Thr Arg Ala Ala Val Glu Glu Gly Val Val Ala Gly Gly Gly 
                405                 410                 415     


Val Ala Leu Ile Arg Val Ala Ser Lys Leu Ala Asp Leu Arg Gly Gln 
            420                 425                 430         


Asn Glu Asp Gln Asn Val Gly Ile Lys Val Ala Leu Arg Ala Met Glu 
        435                 440                 445             


Ala Pro Leu Arg Gln Ile Val Leu Asn Cys Gly Glu Glu Pro Ser Val 
    450                 455                 460                 


Val Ala Asn Thr Val Lys Gly Gly Asp Gly Asn Tyr Gly Tyr Asn Ala 
465                 470                 475                 480 


Ala Thr Glu Glu Tyr Gly Asn Met Ile Asp Met Gly Ile Leu Asp Pro 
                485                 490                 495     


Thr Lys Val Thr Arg Ser Ala Leu Gln Tyr Ala Ala Ser Val Ala Gly 
            500                 505                 510         


Leu Met Ile Thr Thr Glu Cys Met Val Thr Asp Leu Pro Lys Asn Asp 
        515                 520                 525             


Ala Ala Asp Leu Gly Ala Ala Gly Gly Met Gly Gly Met Gly Gly Met 
    530                 535                 540                 


Gly Gly Met Met 
545             


