                         SEQUENCE LISTING

<110>  Juvena Therapeutics, Inc.
 
<120>  Regenerative Polypeptides and Uses Thereof

<130>  JTI.0021

<160>  60    

<170>  PatentIn version 3.5

<210>  1
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Signal peptide

<400>  1
atgggagccg cccgcctgct gcccaacctc actctgtgct tacagctgct gattctctgc       60

tgtcaa                                                                  66


<210>  2
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Signal peptide

<400>  2
atggggctgg cctggggact aggcgtcctg ttcctgatgc atgtgtgtgg cacc             54


<210>  3
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Signal peptide

<400>  3
atgggaatcc caatggggaa gtcgatgctg gtgcttctca ccttcttggc cttcgcctcg       60

tgctgcattg ct                                                           72


<210>  4
<211>  87
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Signal peptide

<400>  4
atgcacgtgc gctcactgcg agctgcggcg ccgcacagct tcgtggcgct ctgggcaccc       60

ctgttcctgc tgcgctccgc cctggcc                                           87


<210>  5
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Signal peptide

<400>  5
atgaagtggg taacctttat ttcccttctt tttctcttta gctcggctta ttcc             54


<210>  6
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Signal peptide

<400>  6
atgacccggc tgacagtcct ggccctgctg gctggtctgc tggcgtcctc gagggcc          57


<210>  7
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Signal peptide

<400>  7
atgagggcct ggatcttctt tctcctttgc ctggccggga gggctctggc agca             54


<210>  8
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Signal peptide

<400>  8
atgggagtca aagttctgtt tgccctgatc tgcatcgctg tggccgaggc c                51


<210>  9
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal peptide

<400>  9

Met Gly Ala Ala Arg Leu Leu Pro Asn Leu Thr Leu Cys Leu Gln Leu 
1               5                   10                  15      


Leu Ile Leu Cys Cys Gln 
            20          


<210>  10
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal peptide

<400>  10

Met Gly Leu Ala Trp Gly Leu Gly Val Leu Phe Leu Met His Val Cys 
1               5                   10                  15      


Gly Thr 
        


<210>  11
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal peptide

<400>  11

Met Gly Ile Pro Met Gly Lys Ser Met Leu Val Leu Leu Thr Phe Leu 
1               5                   10                  15      


Ala Phe Ala Ser Cys Cys Ile Ala 
            20                  


<210>  12
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal peptide

<400>  12

Met His Val Arg Ser Leu Arg Ala Ala Ala Pro His Ser Phe Val Ala 
1               5                   10                  15      


Leu Trp Ala Pro Leu Phe Leu Leu Arg Ser Ala Leu Ala 
            20                  25                  


<210>  13
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal peptide

<400>  13

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser 
        


<210>  14
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal peptide

<400>  14

Met Thr Arg Leu Thr Val Leu Ala Leu Leu Ala Gly Leu Leu Ala Ser 
1               5                   10                  15      


Ser Arg Ala 
            


<210>  15
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal peptide

<400>  15

Met Arg Ala Trp Ile Phe Phe Leu Leu Cys Leu Ala Gly Arg Ala Leu 
1               5                   10                  15      


Ala Ala 
        


<210>  16
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal peptide

<400>  16

Met Gly Val Lys Val Leu Phe Ala Leu Ile Cys Ile Ala Val Ala Glu 
1               5                   10                  15      


Ala 
    


<210>  17
<211>  201
<212>  DNA
<213>  Homo sapiens

<400>  17
gcttaccgcc ccagtgagac cctgtgcggc ggggagctgg tggacaccct ccagttcgtc       60

tgtggggacc gcggcttcta cttcagcagg cccgcaagcc gtgtgagccg tcgcagccgt      120

ggcatcgttg aggagtgctg tttccgcagc tgtgacctgg ccctcctgga gacgtactgt      180

gctacccccg ccaagtccga g                                                201


<210>  18
<211>  894
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  18
gcttaccgcc ccagtgagac cctgtgcggc ggggagctgg tggacaccct ccagttcgtc       60

tgtggggacc gcggcttcta cttcagcagg cccgcaagcc gtgtgagccg tcgcagccgt      120

ggcatcgttg aggagtgctg tttccgcagc tgtgacctgg ccctcctgga gacgtactgt      180

gctacccccg ccaagtccga gggatcggga tcggacaaaa ctcacacatg cccaccgtgc      240

ccagcacctg aagctgccgg gggaccgtca gtcttcctct tccccccaaa acccaaggac      300

accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa      360

gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca      420

aagccgcggg aggagcagta caacagcacg taccgtgtgg tcagcgtcct caccgtcctg      480

caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa agccctcggc      540

gcccccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagaacc acaggtgtac      600

accctgcccc catcccggga tgagctgacc aagaaccagg tcagcctgac ctgcctggtc      660

aaaggcttct atcccagcga catcgccgtg gagtgggaga gcaatgggca gccggagaac      720

aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct ctacagcaag      780

ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc cgtgatgcat      840

gaggctctgc acaaccacta cacgcagaaa agcctctccc tgtctccggg taaa            894


<210>  19
<211>  897
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  19
gcttaccgcc ccagtgagac cctgtgcggc ggggagctgg tggacaccct ccagttcgtc       60

tgtggggacc gcggcttcta cttcagcagg cccgcaagcc gtgtgagccg tcgcagccgt      120

ggcatcgttg aggagtgctg tttccgcagc tgtgacctgg ccctcctgga gacgtactgt      180

gctacccccg ccaagtccga gggatctggg agcgctgaca aaactcacac atgcccaccg      240

tgcccagcac ctgaagctgc cgggggaccg tcagtcttcc tcttcccccc aaaacccaag      300

gacaccctca tgatctcccg gacccctgag gtcacatgcg tggtggtgga cgtgagccac      360

gaagaccctg aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag      420

acaaagccgc gggaggagca gtacaacagc acgtaccgtg tggtcagcgt cctcaccgtc      480

ctgcaccagg actggctgaa tggcaaggag tacaagtgca aggtctccaa caaagccctc      540

ggcgccccca tcgagaaaac catctccaaa gccaaagggc agccccgaga accacaggtg      600

tacaccctgc ccccatcccg ggatgagctg accaagaacc aggtcagcct gacctgcctg      660

gtcaaaggct tctatcccag cgacatcgcc gtggagtggg agagcaatgg gcagccggag      720

aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctacagc      780

aagctcaccg tggacaagag caggtggcag caggggaacg tcttctcatg ctccgtgatg      840

catgaggctc tgcacaacca ctacacgcag aaaagcctct ccctgtctcc gggtaaa         897


<210>  20
<211>  2025
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  20
caccatcacc atcaccatag cggcgatgca cacaagagtg aggttgctca tcggtttaaa       60

gatttgggag aagaaaattt caaagccttg gtgttgattg cctttgctca gtatcttcag      120

cagtgtccat ttgaagatca tgtaaaatta gtgaatgaag taactgaatt tgcaaaaaca      180

tgtgttgctg atgagtcagc tgaaaattgt gacaaatcac ttcataccct ttttggagac      240

aaattatgca cagttgcaac tcttcgtgaa acctatggtg aaatggctga ctgctgtgca      300

aaacaagaac ctgagagaaa tgaatgcttc ttgcaacaca aagatgacaa cccaaacctc      360

ccccgattgg tgagaccaga ggttgatgtg atgtgcactg cttttcatga caatgaagag      420

acatttttga aaaaatactt atatgaaatt gccagaagac atccttactt ttatgccccg      480

gaactccttt tctttgctaa aaggtataaa gctgctttta cagaatgttg ccaagctgct      540

gataaagctg cctgcctgtt gccaaagctc gatgaacttc gggatgaagg gaaggcttcg      600

tctgccaaac agagactcaa gtgtgccagt ctccaaaaat ttggagaaag agctttcaaa      660

gcatgggcag tagctcgcct gagccagaga tttcccaaag ctgagtttgc agaagtttcc      720

aagttagtga cagatcttac caaagtccac acggaatgct gccatggaga tctgcttgaa      780

tgtgctgatg acagggcgga ccttgccaag tatatctgtg aaaatcaaga ttcgatctcc      840

agtaaactga aggaatgctg tgaaaaacct ctgttggaaa aatcccactg cattgccgaa      900

gtggaaaatg atgagatgcc tgctgacttg ccttcattag ctgctgattt tgttgaaagt      960

aaggatgttt gcaaaaacta tgctgaggca aaggatgtct tcctgggcat gtttttgtat     1020

gaatatgcaa gaaggcatcc tgattactct gtcgtgctgc tgctgagact tgccaagaca     1080

tatgaaacca ctctagagaa gtgctgtgcc gctgcagatc ctcatgaatg ctatgccaaa     1140

gtgttcgatg aatttaaacc tcttgtggaa gagcctcaga atttaatcaa acaaaattgt     1200

gagctttttg agcagcttgg agagtacaaa ttccagaatg cgctattagt tcgttacacc     1260

aagaaagtac cccaagtgtc aactccaact cttgtagagg tctcaagaaa cctaggaaaa     1320

gtgggcagca aatgttgtaa acatcctgaa gcaaaaagaa tgccctgtgc agaagactat     1380

ctatccgtgg tcctgaacca gttatgtgtg ttgcatgaga aaacgccagt aagtgacaga     1440

gtcaccaaat gctgcacaga atccttggtg aacaggcgac catgcttttc agctctggaa     1500

gtcgatgaaa catacgttcc caaagagttt aatgctgaaa cattcacctt ccatgcagat     1560

atatgcacac tttctgagaa ggagagacaa atcaagaaac aaactgcact tgttgagctc     1620

gtgaaacaca agcccaaggc aacaaaagag caactgaaag ctgttatgga tgatttcgca     1680

gcttttgtag agaagtgctg caaggctgac gataaggaga cctgctttgc cgaggagggt     1740

aaaaaacttg ttgctgcaag tcaagctgcc ttaggcttag gcggaggcgg tagcggaggc     1800

ggtggctccg gtggcggagg gtctgcttac cgccccagtg agaccctgtg cggcggggag     1860

ctggtggaca ccctccagtt cgtctgtggg gaccgcggct tctacttcag caggcccgca     1920

agccgtgtga gccgtcgcag ccgtggcatc gttgaggagt gctgtttccg cagctgtgac     1980

ctggccctcc tggagacgta ctgtgctacc cccgccaagt ccgag                     2025


<210>  21
<211>  2025
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  21
caccatcacc atcaccatag cggcgatgca cacaagagtg aggttgctca tcggtttaaa       60

gatttgggag aagaaaattt caaagccttg gtgttgattg cctttgctca gtatcttcag      120

cagtgtccat ttgaagatca tgtaaaatta gtgaatgaag taactgaatt tgcaaaaaca      180

tgtgttgctg atgagtcagc tgaaaattgt gacaaatcac ttcataccct ttttggagac      240

aaattatgca cagttgcaac tcttcgtgaa acctatggtg aaatggctga ctgctgtgca      300

aaacaagaac ctgagagaaa tgaatgcttc ttgcaacaca aagatgacaa cccaaacctc      360

ccccgattgg tgagaccaga ggttgatgtg atgtgcactg cttttcatga caatgaagag      420

acatttttga aaaaatactt atatgaaatt gccagaagac atccttactt ttatgccccg      480

gaactccttt tctttgctaa aaggtataaa gctgctttta cagaatgttg ccaagctgct      540

gataaagctg cctgcctgtt gccaaagctc gatgaacttc gggatgaagg gaaggcttcg      600

tctgccaaac agagactcaa gtgtgccagt ctccaaaaat ttggagaaag agctttcaaa      660

gcatgggcag tagctcgcct gagccagaga tttcccaaag ctgagtttgc agaagtttcc      720

aagttagtga cagatcttac caaagtccac acggaatgct gccatggaga tctgcttgaa      780

tgtgctgatg acagggcgga ccttgccaag tatatctgtg aaaatcaaga ttcgatctcc      840

agtaaactga aggaatgctg tgaaaaacct ctgttggaaa aatcccactg cattgccgaa      900

gtggaaaatg atgagatgcc tgctgacttg ccttcattag ctgctgattt tgttgaaagt      960

aaggatgttt gcaaaaacta tgctgaggca aaggatgtct tcctgggcat gtttttgtat     1020

gaatatgcaa gaaggcatcc tgattactct gtcgtgctgc tgctgagact tgccaagaca     1080

tatgaaacca ctctagagaa gtgctgtgcc gctgcagatc ctcatgaatg ctatgccaaa     1140

gtgttcgatg aatttaaacc tcttgtggaa gagcctcaga atttaatcaa acaaaattgt     1200

gagctttttg agcagcttgg agagtacaaa ttccagaatg cgctattagt tcgttacacc     1260

aagaaagtac cccaagtgtc aactccaact cttgtagagg tctcaagaaa cctaggaaaa     1320

gtgggcagca aatgttgtaa acatcctgaa gcaaaaagaa tgccctgtgc agaagactat     1380

ctatccgtgg tcctgaacca gttatgtgtg ttgcatgaga aaacgccagt aagtgacaga     1440

gtcaccaaat gctgcacaga atccttggtg aacaggcgac catgcttttc agctctggaa     1500

gtcgatgaaa catacgttcc caaagagttt aatgctgaaa cattcacctt ccatgcagat     1560

atatgcacac tttctgagaa ggagagacaa atcaagaaac aaactgcact tgttgagctc     1620

gtgaaacaca agcccaaggc aacaaaagag caactgaaag ctgttatgga tgatttcgca     1680

gcttttgtag agaagtgctg caaggctgac gataaggaga cctgctttgc cgaggagggt     1740

aaaaaacttg ttgctgcaag tcaagctgcc ttaggcttag gcggaggcgg tagcggaggc     1800

ggtggctccg gtggcggagg gtctgcttac cgccccagtg agaccctgtg cggcggggag     1860

ctggtggaca ccctccagtt cgtctgtggg gaccgcggct tctacttcag caggcccgca     1920

agccgtgtga gcgctcgcag ccgtggcatc gttgaggagt gctgtttccg cagctgtgac     1980

ctggccctcc tggagacgta ctgtgctacc cccgccaagt ccgag                     2025


<210>  22
<211>  2025
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  22
caccatcacc atcaccatag cggcgatgca cacaagagtg aggttgctca tcggtttaaa       60

gatttgggag aagaaaattt caaagccttg gtgttgattg cctttgctca gtatcttcag      120

cagtgtccat ttgaagatca tgtaaaatta gtgaatgaag taactgaatt tgcaaaaaca      180

tgtgttgctg atgagtcagc tgaaaattgt gacaaatcac ttcataccct ttttggagac      240

aaattatgca cagttgcaac tcttcgtgaa acctatggtg aaatggctga ctgctgtgca      300

aaacaagaac ctgagagaaa tgaatgcttc ttgcaacaca aagatgacaa cccaaacctc      360

ccccgattgg tgagaccaga ggttgatgtg atgtgcactg cttttcatga caatgaagag      420

acatttttga aaaaatactt atatgaaatt gccagaagac atccttactt ttatgccccg      480

gaactccttt tctttgctaa aaggtataaa gctgctttta cagaatgttg ccaagctgct      540

gataaagctg cctgcctgtt gccaaagctc gatgaacttc gggatgaagg gaaggcttcg      600

tctgccaaac agagactcaa gtgtgccagt ctccaaaaat ttggagaaag agctttcaaa      660

gcatgggcag tagctcgcct gagccagaga tttcccaaag ctgagtttgc agaagtttcc      720

aagttagtga cagatcttac caaagtccac acggaatgct gccatggaga tctgcttgaa      780

tgtgctgatg acagggcgga ccttgccaag tatatctgtg aaaatcaaga ttcgatctcc      840

agtaaactga aggaatgctg tgaaaaacct ctgttggaaa aatcccactg cattgccgaa      900

gtggaaaatg atgagatgcc tgctgacttg ccttcattag ctgctgattt tgttgaaagt      960

aaggatgttt gcaaaaacta tgctgaggca aaggatgtct tcctgggcat gtttttgtat     1020

gaatatgcaa gaaggcatcc tgattactct gtcgtgctgc tgctgagact tgccaagaca     1080

tatgaaacca ctctagagaa gtgctgtgcc gctgcagatc ctcatgaatg ctatgccaaa     1140

gtgttcgatg aatttaaacc tcttgtggaa gagcctcaga atttaatcaa acaaaattgt     1200

gagctttttg agcagcttgg agagtacaaa ttccagaatg cgctattagt tcgttacacc     1260

aagaaagtac cccaagtgtc aactccaact cttgtagagg tctcaagaaa cctaggaaaa     1320

gtgggcagca aatgttgtaa acatcctgaa gcaaaaagaa tgccctgtgc agaagactat     1380

ctatccgtgg tcctgaacca gttatgtgtg ttgcatgaga aaacgccagt aagtgacaga     1440

gtcaccaaat gctgcacaga atccttggtg aacaggcgac catgcttttc agctctggaa     1500

gtcgatgaaa catacgttcc caaagagttt aatgctgaaa cattcacctt ccatgcagat     1560

atatgcacac tttctgagaa ggagagacaa atcaagaaac aaactgcact tgttgagctc     1620

gtgaaacaca agcccaaggc aacaaaagag caactgaaag ctgttatgga tgatttcgca     1680

gcttttgtag agaagtgctg caaggctgac gataaggaga cctgctttgc cgaggagggt     1740

aaaaaacttg ttgctgcaag tcaagctgcc ttaggcttag gcggaggcgg tagcggaggc     1800

ggtggctccg gtggcggagg gtctgcttac cgccccagtg agaccctgtg cggcggggag     1860

ctggtggaca ccctccagtt cgtctgtggg gaccgcggct tctacttcag caggcccgca     1920

agccgtgtga gccagcgcag ccgtggcatc gttgaggagt gctgtttccg cagctgtgac     1980

ctggccctcc tggagacgta ctgtgctacc cccgccaagt ccgag                     2025


<210>  23
<211>  2025
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  23
caccatcacc atcaccatag cggcgatgca cacaagagtg aggttgctca tcggtttaaa       60

gatttgggag aagaaaattt caaagccttg gtgttgattg cctttgctca gtatcttcag      120

cagtgtccat ttgaagatca tgtaaaatta gtgaatgaag taactgaatt tgcaaaaaca      180

tgtgttgctg atgagtcagc tgaaaattgt gacaaatcac ttcataccct ttttggagac      240

aaattatgca cagttgcaac tcttcgtgaa acctatggtg aaatggctga ctgctgtgca      300

aaacaagaac ctgagagaaa tgaatgcttc ttgcaacaca aagatgacaa cccaaacctc      360

ccccgattgg tgagaccaga ggttgatgtg atgtgcactg cttttcatga caatgaagag      420

acatttttga aaaaatactt atatgaaatt gccagaagac atccttactt ttatgccccg      480

gaactccttt tctttgctaa aaggtataaa gctgctttta cagaatgttg ccaagctgct      540

gataaagctg cctgcctgtt gccaaagctc gatgaacttc gggatgaagg gaaggcttcg      600

tctgccaaac agagactcaa gtgtgccagt ctccaaaaat ttggagaaag agctttcaaa      660

gcatgggcag tagctcgcct gagccagaga tttcccaaag ctgagtttgc agaagtttcc      720

aagttagtga cagatcttac caaagtccac acggaatgct gccatggaga tctgcttgaa      780

tgtgctgatg acagggcgga ccttgccaag tatatctgtg aaaatcaaga ttcgatctcc      840

agtaaactga aggaatgctg tgaaaaacct ctgttggaaa aatcccactg cattgccgaa      900

gtggaaaatg atgagatgcc tgctgacttg ccttcattag ctgctgattt tgttgaaagt      960

aaggatgttt gcaaaaacta tgctgaggca aaggatgtct tcctgggcat gtttttgtat     1020

gaatatgcaa gaaggcatcc tgattactct gtcgtgctgc tgctgagact tgccaagaca     1080

tatgaaacca ctctagagaa gtgctgtgcc gctgcagatc ctcatgaatg ctatgccaaa     1140

gtgttcgatg aatttaaacc tcttgtggaa gagcctcaga atttaatcaa acaaaattgt     1200

gagctttttg agcagcttgg agagtacaaa ttccagaatg cgctattagt tcgttacacc     1260

aagaaagtac cccaagtgtc aactccaact cttgtagagg tctcaagaaa cctaggaaaa     1320

gtgggcagca aatgttgtaa acatcctgaa gcaaaaagaa tgccctgtgc agaagactat     1380

ctatccgtgg tcctgaacca gttatgtgtg ttgcatgaga aaacgccagt aagtgacaga     1440

gtcaccaaat gctgcacaga atccttggtg aacaggcgac catgcttttc agctctggaa     1500

gtcgatgaaa catacgttcc caaagagttt aatgctgaaa cattcacctt ccatgcagat     1560

atatgcacac tttctgagaa ggagagacaa atcaagaaac aaactgcact tgttgagctc     1620

gtgaaacaca agcccaaggc aacaaaagag caactgaaag ctgttatgga tgatttcgca     1680

gcttttgtag agaagtgctg caaggctgac gataaggaga cctgctttgc cgaggagggt     1740

aaaaaacttg ttgctgcaag tcaagctgcc ttaggcttag gcggaggcgg tagcggaggc     1800

ggtggctccg gtggcggagg gtctgcttac cgccccagtg agaccctgtg cggcggggag     1860

ctggtggaca ccctccagtt cgtctgtggg gaccgcggct tctacttcag caggcccgca     1920

agccgtgtga gccgtcgcag cgctggcatc gttgaggagt gctgtttccg cagctgtgac     1980

ctggccctcc tggagacgta ctgtgctacc cccgccaagt ccgag                     2025


<210>  24
<211>  2025
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  24
caccatcacc atcaccatag cggcgatgca cacaagagtg aggttgctca tcggtttaaa       60

gatttgggag aagaaaattt caaagccttg gtgttgattg cctttgctca gtatcttcag      120

cagtgtccat ttgaagatca tgtaaaatta gtgaatgaag taactgaatt tgcaaaaaca      180

tgtgttgctg atgagtcagc tgaaaattgt gacaaatcac ttcataccct ttttggagac      240

aaattatgca cagttgcaac tcttcgtgaa acctatggtg aaatggctga ctgctgtgca      300

aaacaagaac ctgagagaaa tgaatgcttc ttgcaacaca aagatgacaa cccaaacctc      360

ccccgattgg tgagaccaga ggttgatgtg atgtgcactg cttttcatga caatgaagag      420

acatttttga aaaaatactt atatgaaatt gccagaagac atccttactt ttatgccccg      480

gaactccttt tctttgctaa aaggtataaa gctgctttta cagaatgttg ccaagctgct      540

gataaagctg cctgcctgtt gccaaagctc gatgaacttc gggatgaagg gaaggcttcg      600

tctgccaaac agagactcaa gtgtgccagt ctccaaaaat ttggagaaag agctttcaaa      660

gcatgggcag tagctcgcct gagccagaga tttcccaaag ctgagtttgc agaagtttcc      720

aagttagtga cagatcttac caaagtccac acggaatgct gccatggaga tctgcttgaa      780

tgtgctgatg acagggcgga ccttgccaag tatatctgtg aaaatcaaga ttcgatctcc      840

agtaaactga aggaatgctg tgaaaaacct ctgttggaaa aatcccactg cattgccgaa      900

gtggaaaatg atgagatgcc tgctgacttg ccttcattag ctgctgattt tgttgaaagt      960

aaggatgttt gcaaaaacta tgctgaggca aaggatgtct tcctgggcat gtttttgtat     1020

gaatatgcaa gaaggcatcc tgattactct gtcgtgctgc tgctgagact tgccaagaca     1080

tatgaaacca ctctagagaa gtgctgtgcc gctgcagatc ctcatgaatg ctatgccaaa     1140

gtgttcgatg aatttaaacc tcttgtggaa gagcctcaga atttaatcaa acaaaattgt     1200

gagctttttg agcagcttgg agagtacaaa ttccagaatg cgctattagt tcgttacacc     1260

aagaaagtac cccaagtgtc aactccaact cttgtagagg tctcaagaaa cctaggaaaa     1320

gtgggcagca aatgttgtaa acatcctgaa gcaaaaagaa tgccctgtgc agaagactat     1380

ctatccgtgg tcctgaacca gttatgtgtg ttgcatgaga aaacgccagt aagtgacaga     1440

gtcaccaaat gctgcacaga atccttggtg aacaggcgac catgcttttc agctctggaa     1500

gtcgatgaaa catacgttcc caaagagttt aatgctgaaa cattcacctt ccatgcagat     1560

atatgcacac tttctgagaa ggagagacaa atcaagaaac aaactgcact tgttgagctc     1620

gtgaaacaca agcccaaggc aacaaaagag caactgaaag ctgttatgga tgatttcgca     1680

gcttttgtag agaagtgctg caaggctgac gataaggaga cctgctttgc cgaggagggt     1740

aaaaaacttg ttgctgcaag tcaagctgcc ttaggcttag gcggaggcgg tagcggaggc     1800

ggtggctccg gtggcggagg gtctgcttac cgccccagtg agaccctgtg cggcggggag     1860

ctggtggaca ccctccagtt cgtctgtggg gaccgcggct tctacttcag caggcccgca     1920

agccgtgtga gccgtcgcag ccagggcatc gttgaggagt gctgtttccg cagctgtgac     1980

ctggccctcc tggagacgta ctgtgctacc cccgccaagt ccgag                     2025


<210>  25
<211>  933
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  25
gcttaccgcc ccagtgagac cctgtgcggc ggggagctgg tggacaccct ccagttcgtc       60

tgtggggacc gcggcttcta cttcagcagg cccgcaagcc gtgtgagccg tcgcagccgt      120

ggcatcgttg aggagtgctg tttccgcagc tgtgacctgg ccctcctgga gacgtactgt      180

gctacccccg ccaagtccga gggcggaggc ggtagcggag gcggtggctc cggtggcgga      240

gggtctgagt ccaaatatgg tcccccatgc ccaccctgcc cagcacctga gttcctgggg      300

ggaccatcag tcttcctgtt ccccccaaaa cccaaggaca ctctcatgat ctcccggacc      360

cctgaggtca cgtgcgtggt ggtggacgtg agccaggaag accccgaggt ccagttcaac      420

tggtacgtgg atggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagttc      480

aacagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaacggc      540

aaggagtaca agtgcaaggt ctccaacaaa ggcctcccgt cctccatcga gaaaaccatc      600

tccaaagcca aagggcagcc ccgagagcca caggtgtaca ccctgccccc atcccaggag      660

gagatgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta ccccagcgac      720

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc      780

gtgctggact ccgacggctc cttcttcctc tacagcaggc tcaccgtgga caagagcagg      840

tggcaggagg ggaatgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac      900

acacagaaga gcctctccct gtctctgggt aaa                                   933


<210>  26
<211>  888
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  26
gcttaccgcc ccagtgagac cctgtgcggc ggggagctgg tggacaccct ccagttcgtc       60

tgtggggacc gcggcttcta cttcagcagg cccgcaagcc gtgtgagccg tcgcagccgt      120

ggcatcgttg aggagtgctg tttccgcagc tgtgacctgg ccctcctgga gacgtactgt      180

gctacccccg ccaagtccga ggagtccaaa tatggtcccc catgcccacc ctgcccagca      240

cctgagttcc tggggggacc atcagtcttc ctgttccccc caaaacccaa ggacactctc      300

atgatctccc ggacccctga ggtcacgtgc gtggtggtgg acgtgagcca ggaagacccc      360

gaggtccagt tcaactggta cgtggatggc gtggaggtgc ataatgccaa gacaaagccg      420

cgggaggagc agttcaacag cacgtaccgt gtggtcagcg tcctcaccgt cctgcaccag      480

gactggctga acggcaagga gtacaagtgc aaggtctcca acaaaggcct cccgtcctcc      540

atcgagaaaa ccatctccaa agccaaaggg cagccccgag agccacaggt gtacaccctg      600

cccccatccc aggaggagat gaccaagaac caggtcagcc tgacctgcct ggtcaaaggc      660

ttctacccca gcgacatcgc cgtggagtgg gagagcaatg ggcagccgga gaacaactac      720

aagaccacgc ctcccgtgct ggactccgac ggctccttct tcctctacag caggctcacc      780

gtggacaaga gcaggtggca ggaggggaat gtcttctcat gctccgtgat gcatgaggct      840

ctgcacaacc actacacaca gaagagcctc tccctgtctc tgggtaaa                   888


<210>  27
<211>  933
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  27
gagtccaaat atggtccccc atgcccaccc tgcccagcac ctgagttcct ggggggacca       60

tcagtcttcc tgttcccccc aaaacccaag gacactctca tgatctcccg gacccctgag      120

gtcacgtgcg tggtggtgga cgtgagccag gaagaccccg aggtccagtt caactggtac      180

gtggatggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gttcaacagc      240

acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa cggcaaggag      300

tacaagtgca aggtctccaa caaaggcctc ccgtcctcca tcgagaaaac catctccaaa      360

gccaaagggc agccccgaga gccacaggtg tacaccctgc ccccatccca ggaggagatg      420

accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctaccccag cgacatcgcc      480

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg      540

gactccgacg gctccttctt cctctacagc aggctcaccg tggacaagag caggtggcag      600

gaggggaatg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacacag      660

aagagcctct ccctgtctct gggtaaaggc ggaggcggta gcggaggcgg tggctccggt      720

ggcggagggt ctgcttaccg ccccagtgag accctgtgcg gcggggagct ggtggacacc      780

ctccagttcg tctgtgggga ccgcggcttc tacttcagca ggcccgcaag ccgtgtgagc      840

cgtcgcagcc gtggcatcgt tgaggagtgc tgtttccgca gctgtgacct ggccctcctg      900

gagacgtact gtgctacccc cgccaagtcc gag                                   933


<210>  28
<211>  933
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  28
gcttaccgcc ccagtgagac cctgtgcggc ggggagctgg tggacaccct ccagttcgtc       60

tgtggggacc gcggcttcta cttcagcagg cccgcaagcc gtgtgagcgc tcgcagccgt      120

ggcatcgttg aggagtgctg tttccgcagc tgtgacctgg ccctcctgga gacgtactgt      180

gctacccccg ccaagtccga gggcggaggc ggtagcggag gcggtggctc cggtggcgga      240

gggtctgagt ccaaatatgg tcccccatgc ccaccctgcc cagcacctga gttcctgggg      300

ggaccatcag tcttcctgtt ccccccaaaa cccaaggaca ctctcatgat ctcccggacc      360

cctgaggtca cgtgcgtggt ggtggacgtg agccaggaag accccgaggt ccagttcaac      420

tggtacgtgg atggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagttc      480

aacagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaacggc      540

aaggagtaca agtgcaaggt ctccaacaaa ggcctcccgt cctccatcga gaaaaccatc      600

tccaaagcca aagggcagcc ccgagagcca caggtgtaca ccctgccccc atcccaggag      660

gagatgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta ccccagcgac      720

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc      780

gtgctggact ccgacggctc cttcttcctc tacagcaggc tcaccgtgga caagagcagg      840

tggcaggagg ggaatgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac      900

acacagaaga gcctctccct gtctctgggt aaa                                   933


<210>  29
<211>  67
<212>  PRT
<213>  Homo sapiens

<400>  29

Ala Tyr Arg Pro Ser Glu Thr Leu Cys Gly Gly Glu Leu Val Asp Thr 
1               5                   10                  15      


Leu Gln Phe Val Cys Gly Asp Arg Gly Phe Tyr Phe Ser Arg Pro Ala 
            20                  25                  30          


Ser Arg Val Ser Arg Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe 
        35                  40                  45              


Arg Ser Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala 
    50                  55                  60                  


Lys Ser Glu 
65          


<210>  30
<211>  298
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  30

Ala Tyr Arg Pro Ser Glu Thr Leu Cys Gly Gly Glu Leu Val Asp Thr 
1               5                   10                  15      


Leu Gln Phe Val Cys Gly Asp Arg Gly Phe Tyr Phe Ser Arg Pro Ala 
            20                  25                  30          


Ser Arg Val Ser Arg Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe 
        35                  40                  45              


Arg Ser Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala 
    50                  55                  60                  


Lys Ser Glu Gly Ser Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys 
65                  70                  75                  80  


Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
                85                  90                  95      


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
            100                 105                 110         


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
        115                 120                 125             


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
    130                 135                 140                 


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
145                 150                 155                 160 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
                165                 170                 175     


Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
            180                 185                 190         


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
        195                 200                 205             


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
    210                 215                 220                 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
225                 230                 235                 240 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
                245                 250                 255     


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
            260                 265                 270         


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
        275                 280                 285             


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    290                 295             


<210>  31
<211>  299
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  31

Ala Tyr Arg Pro Ser Glu Thr Leu Cys Gly Gly Glu Leu Val Asp Thr 
1               5                   10                  15      


Leu Gln Phe Val Cys Gly Asp Arg Gly Phe Tyr Phe Ser Arg Pro Ala 
            20                  25                  30          


Ser Arg Val Ser Arg Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe 
        35                  40                  45              


Arg Ser Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala 
    50                  55                  60                  


Lys Ser Glu Gly Ser Gly Ser Ala Asp Lys Thr His Thr Cys Pro Pro 
65                  70                  75                  80  


Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro 
                85                  90                  95      


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            100                 105                 110         


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
        115                 120                 125             


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
    130                 135                 140                 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
145                 150                 155                 160 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
                165                 170                 175     


Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            180                 185                 190         


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
        195                 200                 205             


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
    210                 215                 220                 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
225                 230                 235                 240 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
                245                 250                 255     


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
            260                 265                 270         


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
        275                 280                 285             


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    290                 295                 


<210>  32
<211>  180
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  32

Met Gly Ile Pro Met Gly Lys Ser Met Leu Val Leu Leu Thr Phe Leu 
1               5                   10                  15      


Ala Phe Ala Ser Cys Cys Ile Ala Ala Tyr Arg Pro Ser Glu Thr Leu 
            20                  25                  30          


Cys Gly Gly Glu Leu Val Asp Thr Leu Gln Phe Val Cys Gly Asp Arg 
        35                  40                  45              


Gly Phe Tyr Phe Ser Arg Pro Ala Ser Arg Val Ser Arg Arg Ser Arg 
    50                  55                  60                  


Gly Ile Val Glu Glu Cys Cys Phe Arg Ser Cys Asp Leu Ala Leu Leu 
65                  70                  75                  80  


Glu Thr Tyr Cys Ala Thr Pro Ala Lys Ser Glu Arg Asp Val Ser Thr 
                85                  90                  95      


Pro Pro Thr Val Leu Pro Asp Asn Phe Pro Arg Tyr Pro Val Gly Lys 
            100                 105                 110         


Phe Phe Gln Tyr Asp Thr Trp Lys Gln Ser Thr Gln Arg Leu Arg Arg 
        115                 120                 125             


Gly Leu Pro Ala Leu Leu Arg Ala Arg Arg Gly His Val Leu Ala Lys 
    130                 135                 140                 


Glu Leu Glu Ala Phe Arg Glu Ala Lys Arg His Arg Pro Leu Ile Ala 
145                 150                 155                 160 


Leu Pro Thr Gln Asp Pro Ala His Gly Gly Ala Pro Pro Glu Met Ala 
                165                 170                 175     


Ser Asn Arg Lys 
            180 


<210>  33
<211>  675
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  33

His His His His His His Ser Gly Asp Ala His Lys Ser Glu Val Ala 
1               5                   10                  15      


His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu 
            20                  25                  30          


Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val 
        35                  40                  45              


Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp 
    50                  55                  60                  


Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp 
65                  70                  75                  80  


Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala 
                85                  90                  95      


Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln 
            100                 105                 110         


His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val 
        115                 120                 125             


Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys 
    130                 135                 140                 


Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro 
145                 150                 155                 160 


Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys 
                165                 170                 175     


Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu 
            180                 185                 190         


Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys 
        195                 200                 205             


Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val 
    210                 215                 220                 


Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser 
225                 230                 235                 240 


Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly 
                245                 250                 255     


Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile 
            260                 265                 270         


Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu 
        275                 280                 285             


Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp 
    290                 295                 300                 


Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser 
305                 310                 315                 320 


Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly 
                325                 330                 335     


Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val 
            340                 345                 350         


Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys 
        355                 360                 365             


Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu 
    370                 375                 380                 


Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys 
385                 390                 395                 400 


Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu 
                405                 410                 415     


Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val 
            420                 425                 430         


Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His 
        435                 440                 445             


Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val 
    450                 455                 460                 


Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg 
465                 470                 475                 480 


Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe 
                485                 490                 495     


Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala 
            500                 505                 510         


Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu 
        515                 520                 525             


Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys 
    530                 535                 540                 


Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala 
545                 550                 555                 560 


Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe 
                565                 570                 575     


Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly 
            580                 585                 590         


Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        595                 600                 605             


Ala Tyr Arg Pro Ser Glu Thr Leu Cys Gly Gly Glu Leu Val Asp Thr 
    610                 615                 620                 


Leu Gln Phe Val Cys Gly Asp Arg Gly Phe Tyr Phe Ser Arg Pro Ala 
625                 630                 635                 640 


Ser Arg Val Ser Arg Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe 
                645                 650                 655     


Arg Ser Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala 
            660                 665                 670         


Lys Ser Glu 
        675 


<210>  34
<211>  675
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  34

His His His His His His Ser Gly Asp Ala His Lys Ser Glu Val Ala 
1               5                   10                  15      


His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu 
            20                  25                  30          


Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val 
        35                  40                  45              


Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp 
    50                  55                  60                  


Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp 
65                  70                  75                  80  


Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala 
                85                  90                  95      


Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln 
            100                 105                 110         


His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val 
        115                 120                 125             


Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys 
    130                 135                 140                 


Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro 
145                 150                 155                 160 


Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys 
                165                 170                 175     


Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu 
            180                 185                 190         


Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys 
        195                 200                 205             


Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val 
    210                 215                 220                 


Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser 
225                 230                 235                 240 


Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly 
                245                 250                 255     


Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile 
            260                 265                 270         


Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu 
        275                 280                 285             


Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp 
    290                 295                 300                 


Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser 
305                 310                 315                 320 


Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly 
                325                 330                 335     


Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val 
            340                 345                 350         


Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys 
        355                 360                 365             


Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu 
    370                 375                 380                 


Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys 
385                 390                 395                 400 


Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu 
                405                 410                 415     


Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val 
            420                 425                 430         


Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His 
        435                 440                 445             


Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val 
    450                 455                 460                 


Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg 
465                 470                 475                 480 


Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe 
                485                 490                 495     


Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala 
            500                 505                 510         


Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu 
        515                 520                 525             


Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys 
    530                 535                 540                 


Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala 
545                 550                 555                 560 


Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe 
                565                 570                 575     


Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly 
            580                 585                 590         


Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        595                 600                 605             


Ala Tyr Arg Pro Ser Glu Thr Leu Cys Gly Gly Glu Leu Val Asp Thr 
    610                 615                 620                 


Leu Gln Phe Val Cys Gly Asp Arg Gly Phe Tyr Phe Ser Arg Pro Ala 
625                 630                 635                 640 


Ser Arg Val Ser Ala Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe 
                645                 650                 655     


Arg Ser Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala 
            660                 665                 670         


Lys Ser Glu 
        675 


<210>  35
<211>  675
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  35

His His His His His His Ser Gly Asp Ala His Lys Ser Glu Val Ala 
1               5                   10                  15      


His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu 
            20                  25                  30          


Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val 
        35                  40                  45              


Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp 
    50                  55                  60                  


Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp 
65                  70                  75                  80  


Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala 
                85                  90                  95      


Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln 
            100                 105                 110         


His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val 
        115                 120                 125             


Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys 
    130                 135                 140                 


Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro 
145                 150                 155                 160 


Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys 
                165                 170                 175     


Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu 
            180                 185                 190         


Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys 
        195                 200                 205             


Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val 
    210                 215                 220                 


Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser 
225                 230                 235                 240 


Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly 
                245                 250                 255     


Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile 
            260                 265                 270         


Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu 
        275                 280                 285             


Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp 
    290                 295                 300                 


Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser 
305                 310                 315                 320 


Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly 
                325                 330                 335     


Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val 
            340                 345                 350         


Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys 
        355                 360                 365             


Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu 
    370                 375                 380                 


Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys 
385                 390                 395                 400 


Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu 
                405                 410                 415     


Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val 
            420                 425                 430         


Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His 
        435                 440                 445             


Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val 
    450                 455                 460                 


Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg 
465                 470                 475                 480 


Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe 
                485                 490                 495     


Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala 
            500                 505                 510         


Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu 
        515                 520                 525             


Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys 
    530                 535                 540                 


Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala 
545                 550                 555                 560 


Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe 
                565                 570                 575     


Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly 
            580                 585                 590         


Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        595                 600                 605             


Ala Tyr Arg Pro Ser Glu Thr Leu Cys Gly Gly Glu Leu Val Asp Thr 
    610                 615                 620                 


Leu Gln Phe Val Cys Gly Asp Arg Gly Phe Tyr Phe Ser Arg Pro Ala 
625                 630                 635                 640 


Ser Arg Val Ser Gln Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe 
                645                 650                 655     


Arg Ser Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala 
            660                 665                 670         


Lys Ser Glu 
        675 


<210>  36
<211>  675
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  36

His His His His His His Ser Gly Asp Ala His Lys Ser Glu Val Ala 
1               5                   10                  15      


His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu 
            20                  25                  30          


Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val 
        35                  40                  45              


Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp 
    50                  55                  60                  


Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp 
65                  70                  75                  80  


Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala 
                85                  90                  95      


Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln 
            100                 105                 110         


His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val 
        115                 120                 125             


Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys 
    130                 135                 140                 


Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro 
145                 150                 155                 160 


Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys 
                165                 170                 175     


Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu 
            180                 185                 190         


Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys 
        195                 200                 205             


Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val 
    210                 215                 220                 


Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser 
225                 230                 235                 240 


Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly 
                245                 250                 255     


Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile 
            260                 265                 270         


Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu 
        275                 280                 285             


Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp 
    290                 295                 300                 


Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser 
305                 310                 315                 320 


Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly 
                325                 330                 335     


Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val 
            340                 345                 350         


Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys 
        355                 360                 365             


Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu 
    370                 375                 380                 


Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys 
385                 390                 395                 400 


Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu 
                405                 410                 415     


Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val 
            420                 425                 430         


Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His 
        435                 440                 445             


Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val 
    450                 455                 460                 


Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg 
465                 470                 475                 480 


Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe 
                485                 490                 495     


Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala 
            500                 505                 510         


Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu 
        515                 520                 525             


Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys 
    530                 535                 540                 


Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala 
545                 550                 555                 560 


Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe 
                565                 570                 575     


Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly 
            580                 585                 590         


Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        595                 600                 605             


Ala Tyr Arg Pro Ser Glu Thr Leu Cys Gly Gly Glu Leu Val Asp Thr 
    610                 615                 620                 


Leu Gln Phe Val Cys Gly Asp Arg Gly Phe Tyr Phe Ser Arg Pro Ala 
625                 630                 635                 640 


Ser Arg Val Ser Arg Arg Ser Ala Gly Ile Val Glu Glu Cys Cys Phe 
                645                 650                 655     


Arg Ser Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala 
            660                 665                 670         


Lys Ser Glu 
        675 


<210>  37
<211>  675
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  37

His His His His His His Ser Gly Asp Ala His Lys Ser Glu Val Ala 
1               5                   10                  15      


His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu 
            20                  25                  30          


Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val 
        35                  40                  45              


Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp 
    50                  55                  60                  


Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp 
65                  70                  75                  80  


Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala 
                85                  90                  95      


Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln 
            100                 105                 110         


His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val 
        115                 120                 125             


Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys 
    130                 135                 140                 


Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro 
145                 150                 155                 160 


Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys 
                165                 170                 175     


Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu 
            180                 185                 190         


Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys 
        195                 200                 205             


Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val 
    210                 215                 220                 


Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser 
225                 230                 235                 240 


Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly 
                245                 250                 255     


Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile 
            260                 265                 270         


Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu 
        275                 280                 285             


Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp 
    290                 295                 300                 


Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser 
305                 310                 315                 320 


Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly 
                325                 330                 335     


Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val 
            340                 345                 350         


Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys 
        355                 360                 365             


Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu 
    370                 375                 380                 


Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys 
385                 390                 395                 400 


Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu 
                405                 410                 415     


Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val 
            420                 425                 430         


Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His 
        435                 440                 445             


Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val 
    450                 455                 460                 


Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg 
465                 470                 475                 480 


Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe 
                485                 490                 495     


Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala 
            500                 505                 510         


Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu 
        515                 520                 525             


Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys 
    530                 535                 540                 


Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala 
545                 550                 555                 560 


Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe 
                565                 570                 575     


Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly 
            580                 585                 590         


Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        595                 600                 605             


Ala Tyr Arg Pro Ser Glu Thr Leu Cys Gly Gly Glu Leu Val Asp Thr 
    610                 615                 620                 


Leu Gln Phe Val Cys Gly Asp Arg Gly Phe Tyr Phe Ser Arg Pro Ala 
625                 630                 635                 640 


Ser Arg Val Ser Arg Arg Ser Gln Gly Ile Val Glu Glu Cys Cys Phe 
                645                 650                 655     


Arg Ser Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala 
            660                 665                 670         


Lys Ser Glu 
        675 


<210>  38
<211>  311
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  38

Ala Tyr Arg Pro Ser Glu Thr Leu Cys Gly Gly Glu Leu Val Asp Thr 
1               5                   10                  15      


Leu Gln Phe Val Cys Gly Asp Arg Gly Phe Tyr Phe Ser Arg Pro Ala 
            20                  25                  30          


Ser Arg Val Ser Arg Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe 
        35                  40                  45              


Arg Ser Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala 
    50                  55                  60                  


Lys Ser Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
65                  70                  75                  80  


Gly Ser Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
                85                  90                  95      


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            100                 105                 110         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        115                 120                 125             


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
    130                 135                 140                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
145                 150                 155                 160 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                165                 170                 175     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
            180                 185                 190         


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        195                 200                 205             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
    210                 215                 220                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
225                 230                 235                 240 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                245                 250                 255     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            260                 265                 270         


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
        275                 280                 285             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    290                 295                 300                 


Leu Ser Leu Ser Leu Gly Lys 
305                 310     


<210>  39
<211>  296
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  39

Ala Tyr Arg Pro Ser Glu Thr Leu Cys Gly Gly Glu Leu Val Asp Thr 
1               5                   10                  15      


Leu Gln Phe Val Cys Gly Asp Arg Gly Phe Tyr Phe Ser Arg Pro Ala 
            20                  25                  30          


Ser Arg Val Ser Arg Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe 
        35                  40                  45              


Arg Ser Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala 
    50                  55                  60                  


Lys Ser Glu Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala 
65                  70                  75                  80  


Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                85                  90                  95      


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            100                 105                 110         


Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val 
        115                 120                 125             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    130                 135                 140                 


Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
145                 150                 155                 160 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly 
                165                 170                 175     


Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            180                 185                 190         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr 
        195                 200                 205             


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    210                 215                 220                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
225                 230                 235                 240 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                245                 250                 255     


Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe 
            260                 265                 270         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        275                 280                 285             


Ser Leu Ser Leu Ser Leu Gly Lys 
    290                 295     


<210>  40
<211>  311
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  40

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
225                 230                 235                 240 


Gly Gly Gly Ser Ala Tyr Arg Pro Ser Glu Thr Leu Cys Gly Gly Glu 
                245                 250                 255     


Leu Val Asp Thr Leu Gln Phe Val Cys Gly Asp Arg Gly Phe Tyr Phe 
            260                 265                 270         


Ser Arg Pro Ala Ser Arg Val Ser Arg Arg Ser Arg Gly Ile Val Glu 
        275                 280                 285             


Glu Cys Cys Phe Arg Ser Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys 
    290                 295                 300                 


Ala Thr Pro Ala Lys Ser Glu 
305                 310     


<210>  41
<211>  311
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  41

Ala Tyr Arg Pro Ser Glu Thr Leu Cys Gly Gly Glu Leu Val Asp Thr 
1               5                   10                  15      


Leu Gln Phe Val Cys Gly Asp Arg Gly Phe Tyr Phe Ser Arg Pro Ala 
            20                  25                  30          


Ser Arg Val Ser Ala Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe 
        35                  40                  45              


Arg Ser Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala 
    50                  55                  60                  


Lys Ser Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
65                  70                  75                  80  


Gly Ser Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
                85                  90                  95      


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            100                 105                 110         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        115                 120                 125             


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
    130                 135                 140                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
145                 150                 155                 160 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                165                 170                 175     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
            180                 185                 190         


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        195                 200                 205             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
    210                 215                 220                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
225                 230                 235                 240 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                245                 250                 255     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            260                 265                 270         


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
        275                 280                 285             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    290                 295                 300                 


Leu Ser Leu Ser Leu Gly Lys 
305                 310     


<210>  42
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Portion of IGF2

<400>  42

Arg Gly Phe Tyr Phe Ser Arg Pro Ala Ser Arg Val Ser Arg Arg Ser 
1               5                   10                  15      


Arg 
    


<210>  43
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Short flexible linker

<400>  43
ggatcgggat cg                                                           12


<210>  44
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Short flexible linker

<400>  44
ggatctggga gcgct                                                        15


<210>  45
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Long flexible linker

<400>  45
ggcggaggcg gtagcggagg cggtggctcc ggtggcggag ggtct                       45


<210>  46
<211>  681
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  46
gacaaaactc acacatgccc accgtgccca gcacctgaag ctgccggggg accgtcagtc       60

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      120

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      180

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac      240

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag      300

tgcaaggtct ccaacaaagc cctcggcgcc cccatcgaga aaaccatctc caaagccaaa      360

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggatga gctgaccaag      420

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag      480

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc      540

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg      600

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaaaagc      660

ctctccctgt ctccgggtaa a                                                681


<210>  47
<211>  687
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  47
gagtccaaat atggtccccc atgcccaccc tgcccagcac ctgagttcct ggggggacca       60

tcagtcttcc tgttcccccc aaaacccaag gacactctca tgatctcccg gacccctgag      120

gtcacgtgcg tggtggtgga cgtgagccag gaagaccccg aggtccagtt caactggtac      180

gtggatggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gttcaacagc      240

acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa cggcaaggag      300

tacaagtgca aggtctccaa caaaggcctc ccgtcctcca tcgagaaaac catctccaaa      360

gccaaagggc agccccgaga gccacaggtg tacaccctgc ccccatccca ggaggagatg      420

accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctaccccag cgacatcgcc      480

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg      540

gactccgacg gctccttctt cctctacagc aggctcaccg tggacaagag caggtggcag      600

gaggggaatg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacacag      660

aagagcctct ccctgtctct gggtaaa                                          687


<210>  48
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Six His peptide

<400>  48
caccatcacc atcaccat                                                     18


<210>  49
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Strep-Tactin binding peptide

<400>  49
tggagccacc cgcagttcga aaaa                                              24


<210>  50
<211>  1755
<212>  DNA
<213>  Homo sapiens

<400>  50
gatgcacaca agagtgaggt tgctcatcgg tttaaagatt tgggagaaga aaatttcaaa       60

gccttggtgt tgattgcctt tgctcagtat cttcagcagt gtccatttga agatcatgta      120

aaattagtga atgaagtaac tgaatttgca aaaacatgtg ttgctgatga gtcagctgaa      180

aattgtgaca aatcacttca tacccttttt ggagacaaat tatgcacagt tgcaactctt      240

cgtgaaacct atggtgaaat ggctgactgc tgtgcaaaac aagaacctga gagaaatgaa      300

tgcttcttgc aacacaaaga tgacaaccca aacctccccc gattggtgag accagaggtt      360

gatgtgatgt gcactgcttt tcatgacaat gaagagacat ttttgaaaaa atacttatat      420

gaaattgcca gaagacatcc ttacttttat gccccggaac tccttttctt tgctaaaagg      480

tataaagctg cttttacaga atgttgccaa gctgctgata aagctgcctg cctgttgcca      540

aagctcgatg aacttcggga tgaagggaag gcttcgtctg ccaaacagag actcaagtgt      600

gccagtctcc aaaaatttgg agaaagagct ttcaaagcat gggcagtagc tcgcctgagc      660

cagagatttc ccaaagctga gtttgcagaa gtttccaagt tagtgacaga tcttaccaaa      720

gtccacacgg aatgctgcca tggagatctg cttgaatgtg ctgatgacag ggcggacctt      780

gccaagtata tctgtgaaaa tcaagattcg atctccagta aactgaagga atgctgtgaa      840

aaacctctgt tggaaaaatc ccactgcatt gccgaagtgg aaaatgatga gatgcctgct      900

gacttgcctt cattagctgc tgattttgtt gaaagtaagg atgtttgcaa aaactatgct      960

gaggcaaagg atgtcttcct gggcatgttt ttgtatgaat atgcaagaag gcatcctgat     1020

tactctgtcg tgctgctgct gagacttgcc aagacatatg aaaccactct agagaagtgc     1080

tgtgccgctg cagatcctca tgaatgctat gccaaagtgt tcgatgaatt taaacctctt     1140

gtggaagagc ctcagaattt aatcaaacaa aattgtgagc tttttgagca gcttggagag     1200

tacaaattcc agaatgcgct attagttcgt tacaccaaga aagtacccca agtgtcaact     1260

ccaactcttg tagaggtctc aagaaaccta ggaaaagtgg gcagcaaatg ttgtaaacat     1320

cctgaagcaa aaagaatgcc ctgtgcagaa gactatctat ccgtggtcct gaaccagtta     1380

tgtgtgttgc atgagaaaac gccagtaagt gacagagtca ccaaatgctg cacagaatcc     1440

ttggtgaaca ggcgaccatg cttttcagct ctggaagtcg atgaaacata cgttcccaaa     1500

gagtttaatg ctgaaacatt caccttccat gcagatatat gcacactttc tgagaaggag     1560

agacaaatca agaaacaaac tgcacttgtt gagctcgtga aacacaagcc caaggcaaca     1620

aaagagcaac tgaaagctgt tatggatgat ttcgcagctt ttgtagagaa gtgctgcaag     1680

gctgacgata aggagacctg ctttgccgag gagggtaaaa aacttgttgc tgcaagtcaa     1740

gctgccttag gctta                                                      1755


<210>  51
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Short flexible linker

<400>  51

Gly Ser Gly Ser 
1               


<210>  52
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Short flexible linker

<400>  52

Gly Ser Gly Ser Ala 
1               5   


<210>  53
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Long flexible linker

<400>  53

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  54
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  54

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  55
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  55

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys 
225                 


<210>  56
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Six His peptide

<400>  56

His His His His His His 
1               5       


<210>  57
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Strp-Tactin binding peptide

<400>  57

Trp Ser His Pro Gln Phe Glu Lys 
1               5               


<210>  58
<211>  585
<212>  PRT
<213>  Homo sapiens

<400>  58

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu 
            580                 585 


<210>  59
<211>  669
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  59

Ser Gly Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu 
1               5                   10                  15      


Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr 
            20                  25                  30          


Leu Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val 
        35                  40                  45              


Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys 
    50                  55                  60                  


Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala 
65                  70                  75                  80  


Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln 
                85                  90                  95      


Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro 
            100                 105                 110         


Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala 
        115                 120                 125             


Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile 
    130                 135                 140                 


Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala 
145                 150                 155                 160 


Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys 
                165                 170                 175     


Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys 
            180                 185                 190         


Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe 
        195                 200                 205             


Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg 
    210                 215                 220                 


Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu 
225                 230                 235                 240 


Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala 
                245                 250                 255     


Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser 
            260                 265                 270         


Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys 
        275                 280                 285             


Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu 
    290                 295                 300                 


Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn 
305                 310                 315                 320 


Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr 
                325                 330                 335     


Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala 
            340                 345                 350         


Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro 
        355                 360                 365             


His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu 
    370                 375                 380                 


Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu 
385                 390                 395                 400 


Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys 
                405                 410                 415     


Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu 
            420                 425                 430         


Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met 
        435                 440                 445             


Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val 
    450                 455                 460                 


Leu His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr 
465                 470                 475                 480 


Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp 
                485                 490                 495     


Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His 
            500                 505                 510         


Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln 
        515                 520                 525             


Thr Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu 
    530                 535                 540                 


Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys 
545                 550                 555                 560 


Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys 
                565                 570                 575     


Leu Val Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Gly Gly Gly Ser 
            580                 585                 590         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Tyr Arg Pro Ser Glu 
        595                 600                 605             


Thr Leu Cys Gly Gly Glu Leu Val Asp Thr Leu Gln Phe Val Cys Gly 
    610                 615                 620                 


Asp Arg Gly Phe Tyr Phe Ser Arg Pro Ala Ser Arg Val Ser Ala Arg 
625                 630                 635                 640 


Ser Arg Gly Ile Val Glu Glu Cys Cys Phe Arg Ser Cys Asp Leu Ala 
                645                 650                 655     


Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala Lys Ser Glu 
            660                 665                 


<210>  60
<211>  675
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  60

Arg Gly Val Phe Arg Arg Ser Gly Asp Ala His Lys Ser Glu Val Ala 
1               5                   10                  15      


His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu 
            20                  25                  30          


Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val 
        35                  40                  45              


Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp 
    50                  55                  60                  


Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp 
65                  70                  75                  80  


Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala 
                85                  90                  95      


Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln 
            100                 105                 110         


His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val 
        115                 120                 125             


Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys 
    130                 135                 140                 


Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro 
145                 150                 155                 160 


Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys 
                165                 170                 175     


Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu 
            180                 185                 190         


Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys 
        195                 200                 205             


Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val 
    210                 215                 220                 


Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser 
225                 230                 235                 240 


Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly 
                245                 250                 255     


Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile 
            260                 265                 270         


Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu 
        275                 280                 285             


Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp 
    290                 295                 300                 


Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser 
305                 310                 315                 320 


Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly 
                325                 330                 335     


Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val 
            340                 345                 350         


Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys 
        355                 360                 365             


Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu 
    370                 375                 380                 


Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys 
385                 390                 395                 400 


Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu 
                405                 410                 415     


Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val 
            420                 425                 430         


Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His 
        435                 440                 445             


Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val 
    450                 455                 460                 


Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg 
465                 470                 475                 480 


Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe 
                485                 490                 495     


Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala 
            500                 505                 510         


Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu 
        515                 520                 525             


Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys 
    530                 535                 540                 


Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala 
545                 550                 555                 560 


Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe 
                565                 570                 575     


Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly 
            580                 585                 590         


Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        595                 600                 605             


Ala Tyr Arg Pro Ser Glu Thr Leu Cys Gly Gly Glu Leu Val Asp Thr 
    610                 615                 620                 


Leu Gln Phe Val Cys Gly Asp Arg Gly Phe Tyr Phe Ser Arg Pro Ala 
625                 630                 635                 640 


Ser Arg Val Ser Ala Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe 
                645                 650                 655     


Arg Ser Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala 
            660                 665                 670         


Lys Ser Glu 
        675 


