                         SEQUENCE LISTING

<110>  Bioverativ Therapeutics, Inc.
 
<120>  FORMULATIONS OF FACTOR VIII CHIMERIC PROTEINS AND

<130>  730463: SA9-480PC

<150>  63/214,245
<151>  2021-06-23

<150>  63/214,246
<151>  2021-06-23

<150>  63/214,752
<151>  2021-06-24

<150>  63/231,909
<151>  2021-08-11

<160>  24    

<170>  PatentIn version 3.5

<210>  1
<211>  1946
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  1

Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 
1               5                   10                  15      


Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 
            20                  25                  30          


Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 
        35                  40                  45              


Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro 
    50                  55                  60                  


Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val 
65                  70                  75                  80  


Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 
                85                  90                  95      


Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 
            100                 105                 110         


Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val 
        115                 120                 125             


Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn 
    130                 135                 140                 


Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser 
145                 150                 155                 160 


His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 
                165                 170                 175     


Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu 
            180                 185                 190         


His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp 
        195                 200                 205             


His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser 
    210                 215                 220                 


Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg 
225                 230                 235                 240 


Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His 
                245                 250                 255     


Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu 
            260                 265                 270         


Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 
        275                 280                 285             


Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly 
    290                 295                 300                 


Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met 
305                 310                 315                 320 


Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg 
                325                 330                 335     


Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp 
            340                 345                 350         


Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe 
        355                 360                 365             


Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His 
    370                 375                 380                 


Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu 
385                 390                 395                 400 


Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro 
                405                 410                 415     


Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr 
            420                 425                 430         


Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile 
        435                 440                 445             


Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile 
    450                 455                 460                 


Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile 
465                 470                 475                 480 


Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys 
                485                 490                 495     


His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys 
            500                 505                 510         


Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys 
        515                 520                 525             


Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala 
    530                 535                 540                 


Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp 
545                 550                 555                 560 


Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu Phe 
                565                 570                 575     


Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln 
            580                 585                 590         


Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp Pro Glu Phe 
        595                 600                 605             


Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser 
    610                 615                 620                 


Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu 
625                 630                 635                 640 


Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr 
                645                 650                 655     


Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro 
            660                 665                 670         


Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp 
        675                 680                 685             


Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala 
    690                 695                 700                 


Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu 
705                 710                 715                 720 


Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala 
                725                 730                 735     


Ile Glu Pro Arg Ser Phe Ser Gln Asn Gly Thr Ser Glu Ser Ala Thr 
            740                 745                 750         


Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 
        755                 760                 765             


Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu 
    770                 775                 780                 


Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr 
785                 790                 795                 800 


Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 
                805                 810                 815     


Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser 
            820                 825                 830         


Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser 
        835                 840                 845             


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 
    850                 855                 860                 


Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro 
865                 870                 875                 880 


Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser 
                885                 890                 895     


Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 
            900                 905                 910         


Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser 
        915                 920                 925             


Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser 
    930                 935                 940                 


Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 
945                 950                 955                 960 


Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser 
                965                 970                 975     


Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser 
            980                 985                 990         


Glu Gly Ser Ala Pro Gly Ser Glu  Pro Ala Thr Ser Gly  Ser Glu Thr 
        995                 1000                 1005             


Pro Gly  Thr Ser Glu Ser Ala  Thr Pro Glu Ser Gly  Pro Gly Thr 
    1010                 1015                 1020             


Ser Thr  Glu Pro Ser Glu Gly  Ser Ala Pro Ala Ser  Ser Glu Ile 
    1025                 1030                 1035             


Thr Arg  Thr Thr Leu Gln Ser  Asp Gln Glu Glu Ile  Asp Tyr Asp 
    1040                 1045                 1050             


Asp Thr  Ile Ser Val Glu Met  Lys Lys Glu Asp Phe  Asp Ile Tyr 
    1055                 1060                 1065             


Asp Glu  Asp Glu Asn Gln Ser  Pro Arg Ser Phe Gln  Lys Lys Thr 
    1070                 1075                 1080             


Arg His  Tyr Phe Ile Ala Ala  Val Glu Arg Leu Trp  Asp Tyr Gly 
    1085                 1090                 1095             


Met Ser  Ser Ser Pro His Val  Leu Arg Asn Arg Ala  Gln Ser Gly 
    1100                 1105                 1110             


Ser Val  Pro Gln Phe Lys Lys  Val Val Phe Gln Glu  Phe Thr Asp 
    1115                 1120                 1125             


Gly Ser  Phe Thr Gln Pro Leu  Tyr Arg Gly Glu Leu  Asn Glu His 
    1130                 1135                 1140             


Leu Gly  Leu Leu Gly Pro Tyr  Ile Arg Ala Glu Val  Glu Asp Asn 
    1145                 1150                 1155             


Ile Met  Val Thr Phe Arg Asn  Gln Ala Ser Arg Pro  Tyr Ser Phe 
    1160                 1165                 1170             


Tyr Ser  Ser Leu Ile Ser Tyr  Glu Glu Asp Gln Arg  Gln Gly Ala 
    1175                 1180                 1185             


Glu Pro  Arg Lys Asn Phe Val  Lys Pro Asn Glu Thr  Lys Thr Tyr 
    1190                 1195                 1200             


Phe Trp  Lys Val Gln His His  Met Ala Pro Thr Lys  Asp Glu Phe 
    1205                 1210                 1215             


Asp Cys  Lys Ala Trp Ala Tyr  Phe Ser Asp Val Asp  Leu Glu Lys 
    1220                 1225                 1230             


Asp Val  His Ser Gly Leu Ile  Gly Pro Leu Leu Val  Cys His Thr 
    1235                 1240                 1245             


Asn Thr  Leu Asn Pro Ala His  Gly Arg Gln Val Thr  Val Gln Glu 
    1250                 1255                 1260             


Phe Ala  Leu Phe Phe Thr Ile  Phe Asp Glu Thr Lys  Ser Trp Tyr 
    1265                 1270                 1275             


Phe Thr  Glu Asn Met Glu Arg  Asn Cys Arg Ala Pro  Cys Asn Ile 
    1280                 1285                 1290             


Gln Met  Glu Asp Pro Thr Phe  Lys Glu Asn Tyr Arg  Phe His Ala 
    1295                 1300                 1305             


Ile Asn  Gly Tyr Ile Met Asp  Thr Leu Pro Gly Leu  Val Met Ala 
    1310                 1315                 1320             


Gln Asp  Gln Arg Ile Arg Trp  Tyr Leu Leu Ser Met  Gly Ser Asn 
    1325                 1330                 1335             


Glu Asn  Ile His Ser Ile His  Phe Ser Gly His Val  Phe Thr Val 
    1340                 1345                 1350             


Arg Lys  Lys Glu Glu Tyr Lys  Met Ala Leu Tyr Asn  Leu Tyr Pro 
    1355                 1360                 1365             


Gly Val  Phe Glu Thr Val Glu  Met Leu Pro Ser Lys  Ala Gly Ile 
    1370                 1375                 1380             


Trp Arg  Val Glu Cys Leu Ile  Gly Glu His Leu His  Ala Gly Met 
    1385                 1390                 1395             


Ser Thr  Leu Phe Leu Val Tyr  Ser Asn Lys Cys Gln  Thr Pro Leu 
    1400                 1405                 1410             


Gly Met  Ala Ser Gly His Ile  Arg Asp Phe Gln Ile  Thr Ala Ser 
    1415                 1420                 1425             


Gly Gln  Tyr Gly Gln Trp Ala  Pro Lys Leu Ala Arg  Leu His Tyr 
    1430                 1435                 1440             


Ser Gly  Ser Ile Asn Ala Trp  Ser Thr Lys Glu Pro  Phe Ser Trp 
    1445                 1450                 1455             


Ile Lys  Val Asp Leu Leu Ala  Pro Met Ile Ile His  Gly Ile Lys 
    1460                 1465                 1470             


Thr Gln  Gly Ala Arg Gln Lys  Phe Ser Ser Leu Tyr  Ile Ser Gln 
    1475                 1480                 1485             


Phe Ile  Ile Met Tyr Ser Leu  Asp Gly Lys Lys Trp  Gln Thr Tyr 
    1490                 1495                 1500             


Arg Gly  Asn Ser Thr Gly Thr  Leu Met Val Phe Phe  Gly Asn Val 
    1505                 1510                 1515             


Asp Ser  Ser Gly Ile Lys His  Asn Ile Phe Asn Pro  Pro Ile Ile 
    1520                 1525                 1530             


Ala Arg  Tyr Ile Arg Leu His  Pro Thr His Tyr Ser  Ile Arg Ser 
    1535                 1540                 1545             


Thr Leu  Arg Met Glu Leu Met  Gly Cys Asp Leu Asn  Ser Cys Ser 
    1550                 1555                 1560             


Met Pro  Leu Gly Met Glu Ser  Lys Ala Ile Ser Asp  Ala Gln Ile 
    1565                 1570                 1575             


Thr Ala  Ser Ser Tyr Phe Thr  Asn Met Phe Ala Thr  Trp Ser Pro 
    1580                 1585                 1590             


Ser Lys  Ala Arg Leu His Leu  Gln Gly Arg Ser Asn  Ala Trp Arg 
    1595                 1600                 1605             


Pro Gln  Val Asn Asn Pro Lys  Glu Trp Leu Gln Val  Asp Phe Gln 
    1610                 1615                 1620             


Lys Thr  Met Lys Val Thr Gly  Val Thr Thr Gln Gly  Val Lys Ser 
    1625                 1630                 1635             


Leu Leu  Thr Ser Met Tyr Val  Lys Glu Phe Leu Ile  Ser Ser Ser 
    1640                 1645                 1650             


Gln Asp  Gly His Gln Trp Thr  Leu Phe Phe Gln Asn  Gly Lys Val 
    1655                 1660                 1665             


Lys Val  Phe Gln Gly Asn Gln  Asp Ser Phe Thr Pro  Val Val Asn 
    1670                 1675                 1680             


Ser Leu  Asp Pro Pro Leu Leu  Thr Arg Tyr Leu Arg  Ile His Pro 
    1685                 1690                 1695             


Gln Ser  Trp Val His Gln Ile  Ala Leu Arg Met Glu  Val Leu Gly 
    1700                 1705                 1710             


Cys Glu  Ala Gln Asp Leu Tyr  Asp Lys Thr His Thr  Cys Pro Pro 
    1715                 1720                 1725             


Cys Pro  Ala Pro Glu Leu Leu  Gly Gly Pro Ser Val  Phe Leu Phe 
    1730                 1735                 1740             


Pro Pro  Lys Pro Lys Asp Thr  Leu Met Ile Ser Arg  Thr Pro Glu 
    1745                 1750                 1755             


Val Thr  Cys Val Val Val Asp  Val Ser His Glu Asp  Pro Glu Val 
    1760                 1765                 1770             


Lys Phe  Asn Trp Tyr Val Asp  Gly Val Glu Val His  Asn Ala Lys 
    1775                 1780                 1785             


Thr Lys  Pro Arg Glu Glu Gln  Tyr Asn Ser Thr Tyr  Arg Val Val 
    1790                 1795                 1800             


Ser Val  Leu Thr Val Leu His  Gln Asp Trp Leu Asn  Gly Lys Glu 
    1805                 1810                 1815             


Tyr Lys  Cys Lys Val Ser Asn  Lys Ala Leu Pro Ala  Pro Ile Glu 
    1820                 1825                 1830             


Lys Thr  Ile Ser Lys Ala Lys  Gly Gln Pro Arg Glu  Pro Gln Val 
    1835                 1840                 1845             


Tyr Thr  Leu Pro Pro Ser Arg  Asp Glu Leu Thr Lys  Asn Gln Val 
    1850                 1855                 1860             


Ser Leu  Thr Cys Leu Val Lys  Gly Phe Tyr Pro Ser  Asp Ile Ala 
    1865                 1870                 1875             


Val Glu  Trp Glu Ser Asn Gly  Gln Pro Glu Asn Asn  Tyr Lys Thr 
    1880                 1885                 1890             


Thr Pro  Pro Val Leu Asp Ser  Asp Gly Ser Phe Phe  Leu Tyr Ser 
    1895                 1900                 1905             


Lys Leu  Thr Val Asp Lys Ser  Arg Trp Gln Gln Gly  Asn Val Phe 
    1910                 1915                 1920             


Ser Cys  Ser Val Met His Glu  Ala Leu His Asn His  Tyr Thr Gln 
    1925                 1930                 1935             


Lys Ser  Leu Ser Leu Ser Pro  Gly 
    1940                 1945     


<210>  2
<211>  883
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  2

Ser Leu Ser Cys Arg Pro Pro Met Val Lys Leu Val Cys Pro Ala Asp 
1               5                   10                  15      


Asn Leu Arg Ala Glu Gly Leu Glu Cys Thr Lys Thr Cys Gln Asn Tyr 
            20                  25                  30          


Asp Leu Glu Cys Met Ser Met Gly Cys Val Ser Gly Cys Leu Cys Pro 
        35                  40                  45              


Pro Gly Met Val Arg His Glu Asn Arg Cys Val Ala Leu Glu Arg Cys 
    50                  55                  60                  


Pro Cys Phe His Gln Gly Lys Glu Tyr Ala Pro Gly Glu Thr Val Lys 
65                  70                  75                  80  


Ile Gly Cys Asn Thr Cys Val Cys Arg Asp Arg Lys Trp Asn Cys Thr 
                85                  90                  95      


Asp His Val Cys Asp Ala Thr Cys Ser Thr Ile Gly Met Ala His Tyr 
            100                 105                 110         


Leu Thr Phe Asp Gly Leu Lys Tyr Leu Phe Pro Gly Glu Cys Gln Tyr 
        115                 120                 125             


Val Leu Val Gln Asp Tyr Cys Gly Ser Asn Pro Gly Thr Phe Arg Ile 
    130                 135                 140                 


Leu Val Gly Asn Lys Gly Cys Ser His Pro Ser Val Lys Cys Lys Lys 
145                 150                 155                 160 


Arg Val Thr Ile Leu Val Glu Gly Gly Glu Ile Glu Leu Phe Asp Gly 
                165                 170                 175     


Glu Val Asn Val Lys Arg Pro Met Lys Asp Glu Thr His Phe Glu Val 
            180                 185                 190         


Val Glu Ser Gly Arg Tyr Ile Ile Leu Leu Leu Gly Lys Ala Leu Ser 
        195                 200                 205             


Val Val Trp Asp Arg His Leu Ser Ile Ser Val Val Leu Lys Gln Thr 
    210                 215                 220                 


Tyr Gln Glu Lys Val Cys Gly Leu Cys Gly Asn Phe Asp Gly Ile Gln 
225                 230                 235                 240 


Asn Asn Asp Leu Thr Ser Ser Asn Leu Gln Val Glu Glu Asp Pro Val 
                245                 250                 255     


Asp Phe Gly Asn Ser Trp Lys Val Ser Ser Gln Cys Ala Asp Thr Arg 
            260                 265                 270         


Lys Val Pro Leu Asp Ser Ser Pro Ala Thr Cys His Asn Asn Ile Met 
        275                 280                 285             


Lys Gln Thr Met Val Asp Ser Ser Cys Arg Ile Leu Thr Ser Asp Val 
    290                 295                 300                 


Phe Gln Asp Cys Asn Lys Leu Val Asp Pro Glu Pro Tyr Leu Asp Val 
305                 310                 315                 320 


Cys Ile Tyr Asp Thr Cys Ser Cys Glu Ser Ile Gly Asp Cys Ala Ala 
                325                 330                 335     


Phe Cys Asp Thr Ile Ala Ala Tyr Ala His Val Cys Ala Gln His Gly 
            340                 345                 350         


Lys Val Val Thr Trp Arg Thr Ala Thr Leu Cys Pro Gln Ser Cys Glu 
        355                 360                 365             


Glu Arg Asn Leu Arg Glu Asn Gly Tyr Glu Ala Glu Trp Arg Tyr Asn 
    370                 375                 380                 


Ser Cys Ala Pro Ala Cys Gln Val Thr Cys Gln His Pro Glu Pro Leu 
385                 390                 395                 400 


Ala Cys Pro Val Gln Cys Val Glu Gly Cys His Ala His Cys Pro Pro 
                405                 410                 415     


Gly Lys Ile Leu Asp Glu Leu Leu Gln Thr Cys Val Asp Pro Glu Asp 
            420                 425                 430         


Cys Pro Val Cys Glu Val Ala Gly Arg Arg Phe Ala Ser Gly Lys Lys 
        435                 440                 445             


Val Thr Leu Asn Pro Ser Asp Pro Glu His Cys Gln Ile Cys His Cys 
    450                 455                 460                 


Asp Val Val Asn Leu Thr Cys Glu Ala Cys Gln Glu Pro Gly Thr Ser 
465                 470                 475                 480 


Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser 
                485                 490                 495     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 
            500                 505                 510         


Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser 
        515                 520                 525             


Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser 
    530                 535                 540                 


Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu 
545                 550                 555                 560 


Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu 
                565                 570                 575     


Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr 
            580                 585                 590         


Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu 
        595                 600                 605             


Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ala Ser 
    610                 615                 620                 


Ser Asp Lys Asn Thr Gly Asp Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile 
625                 630                 635                 640 


Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala Ile Glu Pro Arg Ser Phe 
                645                 650                 655     


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
            660                 665                 670         


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
        675                 680                 685             


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
    690                 695                 700                 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
705                 710                 715                 720 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
                725                 730                 735     


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
            740                 745                 750         


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
        755                 760                 765             


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
    770                 775                 780                 


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
785                 790                 795                 800 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
                805                 810                 815     


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
            820                 825                 830         


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
        835                 840                 845             


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
    850                 855                 860                 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
865                 870                 875                 880 


Ser Pro Gly 
            


<210>  3
<211>  1965
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  3

Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe 
1               5                   10                  15      


Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          


Trp Asp Tyr Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg 
        35                  40                  45              


Phe Pro Pro Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val 
    50                  55                  60                  


Tyr Lys Lys Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile 
65                  70                  75                  80  


Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln 
                85                  90                  95      


Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser 
            100                 105                 110         


His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser 
        115                 120                 125             


Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp 
    130                 135                 140                 


Asp Lys Val Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu 
145                 150                 155                 160 


Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser 
                165                 170                 175     


Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile 
            180                 185                 190         


Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr 
        195                 200                 205             


Gln Thr Leu His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly 
    210                 215                 220                 


Lys Ser Trp His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp 
225                 230                 235                 240 


Ala Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr 
                245                 250                 255     


Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val 
            260                 265                 270         


Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile 
        275                 280                 285             


Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser 
    290                 295                 300                 


Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met 
305                 310                 315                 320 


Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His 
                325                 330                 335     


Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro 
            340                 345                 350         


Gln Leu Arg Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp 
        355                 360                 365             


Leu Thr Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser 
    370                 375                 380                 


Pro Ser Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr 
385                 390                 395                 400 


Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro 
                405                 410                 415     


Leu Val Leu Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn 
            420                 425                 430         


Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met 
        435                 440                 445             


Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu 
    450                 455                 460                 


Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu 
465                 470                 475                 480 


Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro 
                485                 490                 495     


His Gly Ile Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys 
            500                 505                 510         


Gly Val Lys His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe 
        515                 520                 525             


Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp 
    530                 535                 540                 


Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg 
545                 550                 555                 560 


Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu 
                565                 570                 575     


Ser Val Asp Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val 
            580                 585                 590         


Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu 
        595                 600                 605             


Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp 
    610                 615                 620                 


Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val 
625                 630                 635                 640 


Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp 
                645                 650                 655     


Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe 
            660                 665                 670         


Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr 
        675                 680                 685             


Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro 
    690                 695                 700                 


Gly Leu Trp Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly 
705                 710                 715                 720 


Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp 
                725                 730                 735     


Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys 
            740                 745                 750         


Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Gly Thr Ser Glu 
        755                 760                 765             


Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly 
    770                 775                 780                 


Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 
785                 790                 795                 800 


Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu 
                805                 810                 815     


Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu 
            820                 825                 830         


Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 
        835                 840                 845             


Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro 
    850                 855                 860                 


Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 
865                 870                 875                 880 


Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 
                885                 890                 895     


Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr 
            900                 905                 910         


Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 
        915                 920                 925             


Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 
    930                 935                 940                 


Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro 
945                 950                 955                 960 


Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly 
                965                 970                 975     


Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 
            980                 985                 990         


Gly Thr Ser Thr Glu Pro Ser Glu  Gly Ser Ala Pro Gly  Thr Ser Thr 
        995                 1000                 1005             


Glu Pro  Ser Glu Gly Ser Ala  Pro Gly Ser Glu Pro  Ala Thr Ser 
    1010                 1015                 1020             


Gly Ser  Glu Thr Pro Gly Thr  Ser Glu Ser Ala Thr  Pro Glu Ser 
    1025                 1030                 1035             


Gly Pro  Gly Thr Ser Thr Glu  Pro Ser Glu Gly Ser  Ala Pro Ala 
    1040                 1045                 1050             


Ser Ser  Glu Ile Thr Arg Thr  Thr Leu Gln Ser Asp  Gln Glu Glu 
    1055                 1060                 1065             


Ile Asp  Tyr Asp Asp Thr Ile  Ser Val Glu Met Lys  Lys Glu Asp 
    1070                 1075                 1080             


Phe Asp  Ile Tyr Asp Glu Asp  Glu Asn Gln Ser Pro  Arg Ser Phe 
    1085                 1090                 1095             


Gln Lys  Lys Thr Arg His Tyr  Phe Ile Ala Ala Val  Glu Arg Leu 
    1100                 1105                 1110             


Trp Asp  Tyr Gly Met Ser Ser  Ser Pro His Val Leu  Arg Asn Arg 
    1115                 1120                 1125             


Ala Gln  Ser Gly Ser Val Pro  Gln Phe Lys Lys Val  Val Phe Gln 
    1130                 1135                 1140             


Glu Phe  Thr Asp Gly Ser Phe  Thr Gln Pro Leu Tyr  Arg Gly Glu 
    1145                 1150                 1155             


Leu Asn  Glu His Leu Gly Leu  Leu Gly Pro Tyr Ile  Arg Ala Glu 
    1160                 1165                 1170             


Val Glu  Asp Asn Ile Met Val  Thr Phe Arg Asn Gln  Ala Ser Arg 
    1175                 1180                 1185             


Pro Tyr  Ser Phe Tyr Ser Ser  Leu Ile Ser Tyr Glu  Glu Asp Gln 
    1190                 1195                 1200             


Arg Gln  Gly Ala Glu Pro Arg  Lys Asn Phe Val Lys  Pro Asn Glu 
    1205                 1210                 1215             


Thr Lys  Thr Tyr Phe Trp Lys  Val Gln His His Met  Ala Pro Thr 
    1220                 1225                 1230             


Lys Asp  Glu Phe Asp Cys Lys  Ala Trp Ala Tyr Phe  Ser Asp Val 
    1235                 1240                 1245             


Asp Leu  Glu Lys Asp Val His  Ser Gly Leu Ile Gly  Pro Leu Leu 
    1250                 1255                 1260             


Val Cys  His Thr Asn Thr Leu  Asn Pro Ala His Gly  Arg Gln Val 
    1265                 1270                 1275             


Thr Val  Gln Glu Phe Ala Leu  Phe Phe Thr Ile Phe  Asp Glu Thr 
    1280                 1285                 1290             


Lys Ser  Trp Tyr Phe Thr Glu  Asn Met Glu Arg Asn  Cys Arg Ala 
    1295                 1300                 1305             


Pro Cys  Asn Ile Gln Met Glu  Asp Pro Thr Phe Lys  Glu Asn Tyr 
    1310                 1315                 1320             


Arg Phe  His Ala Ile Asn Gly  Tyr Ile Met Asp Thr  Leu Pro Gly 
    1325                 1330                 1335             


Leu Val  Met Ala Gln Asp Gln  Arg Ile Arg Trp Tyr  Leu Leu Ser 
    1340                 1345                 1350             


Met Gly  Ser Asn Glu Asn Ile  His Ser Ile His Phe  Ser Gly His 
    1355                 1360                 1365             


Val Phe  Thr Val Arg Lys Lys  Glu Glu Tyr Lys Met  Ala Leu Tyr 
    1370                 1375                 1380             


Asn Leu  Tyr Pro Gly Val Phe  Glu Thr Val Glu Met  Leu Pro Ser 
    1385                 1390                 1395             


Lys Ala  Gly Ile Trp Arg Val  Glu Cys Leu Ile Gly  Glu His Leu 
    1400                 1405                 1410             


His Ala  Gly Met Ser Thr Leu  Phe Leu Val Tyr Ser  Asn Lys Cys 
    1415                 1420                 1425             


Gln Thr  Pro Leu Gly Met Ala  Ser Gly His Ile Arg  Asp Phe Gln 
    1430                 1435                 1440             


Ile Thr  Ala Ser Gly Gln Tyr  Gly Gln Trp Ala Pro  Lys Leu Ala 
    1445                 1450                 1455             


Arg Leu  His Tyr Ser Gly Ser  Ile Asn Ala Trp Ser  Thr Lys Glu 
    1460                 1465                 1470             


Pro Phe  Ser Trp Ile Lys Val  Asp Leu Leu Ala Pro  Met Ile Ile 
    1475                 1480                 1485             


His Gly  Ile Lys Thr Gln Gly  Ala Arg Gln Lys Phe  Ser Ser Leu 
    1490                 1495                 1500             


Tyr Ile  Ser Gln Phe Ile Ile  Met Tyr Ser Leu Asp  Gly Lys Lys 
    1505                 1510                 1515             


Trp Gln  Thr Tyr Arg Gly Asn  Ser Thr Gly Thr Leu  Met Val Phe 
    1520                 1525                 1530             


Phe Gly  Asn Val Asp Ser Ser  Gly Ile Lys His Asn  Ile Phe Asn 
    1535                 1540                 1545             


Pro Pro  Ile Ile Ala Arg Tyr  Ile Arg Leu His Pro  Thr His Tyr 
    1550                 1555                 1560             


Ser Ile  Arg Ser Thr Leu Arg  Met Glu Leu Met Gly  Cys Asp Leu 
    1565                 1570                 1575             


Asn Ser  Cys Ser Met Pro Leu  Gly Met Glu Ser Lys  Ala Ile Ser 
    1580                 1585                 1590             


Asp Ala  Gln Ile Thr Ala Ser  Ser Tyr Phe Thr Asn  Met Phe Ala 
    1595                 1600                 1605             


Thr Trp  Ser Pro Ser Lys Ala  Arg Leu His Leu Gln  Gly Arg Ser 
    1610                 1615                 1620             


Asn Ala  Trp Arg Pro Gln Val  Asn Asn Pro Lys Glu  Trp Leu Gln 
    1625                 1630                 1635             


Val Asp  Phe Gln Lys Thr Met  Lys Val Thr Gly Val  Thr Thr Gln 
    1640                 1645                 1650             


Gly Val  Lys Ser Leu Leu Thr  Ser Met Tyr Val Lys  Glu Phe Leu 
    1655                 1660                 1665             


Ile Ser  Ser Ser Gln Asp Gly  His Gln Trp Thr Leu  Phe Phe Gln 
    1670                 1675                 1680             


Asn Gly  Lys Val Lys Val Phe  Gln Gly Asn Gln Asp  Ser Phe Thr 
    1685                 1690                 1695             


Pro Val  Val Asn Ser Leu Asp  Pro Pro Leu Leu Thr  Arg Tyr Leu 
    1700                 1705                 1710             


Arg Ile  His Pro Gln Ser Trp  Val His Gln Ile Ala  Leu Arg Met 
    1715                 1720                 1725             


Glu Val  Leu Gly Cys Glu Ala  Gln Asp Leu Tyr Asp  Lys Thr His 
    1730                 1735                 1740             


Thr Cys  Pro Pro Cys Pro Ala  Pro Glu Leu Leu Gly  Gly Pro Ser 
    1745                 1750                 1755             


Val Phe  Leu Phe Pro Pro Lys  Pro Lys Asp Thr Leu  Met Ile Ser 
    1760                 1765                 1770             


Arg Thr  Pro Glu Val Thr Cys  Val Val Val Asp Val  Ser His Glu 
    1775                 1780                 1785             


Asp Pro  Glu Val Lys Phe Asn  Trp Tyr Val Asp Gly  Val Glu Val 
    1790                 1795                 1800             


His Asn  Ala Lys Thr Lys Pro  Arg Glu Glu Gln Tyr  Asn Ser Thr 
    1805                 1810                 1815             


Tyr Arg  Val Val Ser Val Leu  Thr Val Leu His Gln  Asp Trp Leu 
    1820                 1825                 1830             


Asn Gly  Lys Glu Tyr Lys Cys  Lys Val Ser Asn Lys  Ala Leu Pro 
    1835                 1840                 1845             


Ala Pro  Ile Glu Lys Thr Ile  Ser Lys Ala Lys Gly  Gln Pro Arg 
    1850                 1855                 1860             


Glu Pro  Gln Val Tyr Thr Leu  Pro Pro Ser Arg Asp  Glu Leu Thr 
    1865                 1870                 1875             


Lys Asn  Gln Val Ser Leu Thr  Cys Leu Val Lys Gly  Phe Tyr Pro 
    1880                 1885                 1890             


Ser Asp  Ile Ala Val Glu Trp  Glu Ser Asn Gly Gln  Pro Glu Asn 
    1895                 1900                 1905             


Asn Tyr  Lys Thr Thr Pro Pro  Val Leu Asp Ser Asp  Gly Ser Phe 
    1910                 1915                 1920             


Phe Leu  Tyr Ser Lys Leu Thr  Val Asp Lys Ser Arg  Trp Gln Gln 
    1925                 1930                 1935             


Gly Asn  Val Phe Ser Cys Ser  Val Met His Glu Ala  Leu His Asn 
    1940                 1945                 1950             


His Tyr  Thr Gln Lys Ser Leu  Ser Leu Ser Pro Gly  
    1955                 1960                 1965 


<210>  4
<211>  5898
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  4
atgcaaatag agctctccac ctgcttcttt ctgtgccttt tgcgattctg ctttagtgcc       60

accagaagat actacctggg tgcagtggaa ctgtcatggg actatatgca aagtgatctc      120

ggtgagctgc ctgtggacgc aagatttcct cctagagtgc caaaatcttt tccattcaac      180

acctcagtcg tgtacaaaaa gactctgttt gtagaattca cggatcacct tttcaacatc      240

gctaagccaa ggccaccctg gatgggtctg ctaggtccta ccatccaggc tgaggtttat      300

gatacagtgg tcattacact taagaacatg gcttcccatc ctgtcagtct tcatgctgtt      360

ggtgtatcct actggaaagc ttctgaggga gctgaatatg atgatcagac cagtcaaagg      420

gagaaagaag atgataaagt cttccctggt ggaagccata catatgtctg gcaggtcctg      480

aaagagaatg gtccaatggc ctctgaccca ctgtgcctta cctactcata tctttctcat      540

gtggacctgg taaaagactt gaattcaggc ctcattggag ccctactagt atgtagagaa      600

gggagtctgg ccaaggaaaa gacacagacc ttgcacaaat ttatactact ttttgctgta      660

tttgatgaag ggaaaagttg gcactcagaa acaaagaact ccttgatgca ggatagggat      720

gctgcatctg ctcgggcctg gcctaaaatg cacacagtca atggttatgt aaacaggtct      780

ctgccaggtc tgattggatg ccacaggaaa tcagtctatt ggcatgtgat tggaatgggc      840

accactcctg aagtgcactc aatattcctc gaaggtcaca catttcttgt gaggaaccat      900

cgccaggcgt ccttggaaat ctcgccaata actttcctta ctgctcaaac actcttgatg      960

gaccttggac agtttctact gttttgtcat atctcttccc accaacatga tggcatggaa     1020

gcttatgtca aagtagacag ctgtccagag gaaccccaac tacgaatgaa aaataatgaa     1080

gaagcggaag actatgatga tgatcttact gattctgaaa tggatgtggt caggtttgat     1140

gatgacaact ctccttcctt tatccaaatt cgctcagttg ccaagaagca tcctaaaact     1200

tgggtacatt acattgctgc tgaagaggag gactgggact atgctccctt agtcctcgcc     1260

cccgatgaca gaagttataa aagtcaatat ttgaacaatg gccctcagcg gattggtagg     1320

aagtacaaaa aagtccgatt tatggcatac acagatgaaa cctttaagac tcgtgaagct     1380

attcagcatg aatcaggaat cttgggacct ttactttatg gggaagttgg agacacactg     1440

ttgattatat ttaagaatca agcaagcaga ccatataaca tctaccctca cggaatcact     1500

gatgtccgtc ctttgtattc aaggagatta ccaaaaggtg taaaacattt gaaggatttt     1560

ccaattctgc caggagaaat attcaaatat aaatggacag tgactgtaga agatgggcca     1620

actaaatcag atcctcggtg cctgacccgc tattactcta gtttcgttaa tatggagaga     1680

gatctagctt caggactcat tggccctctc ctcatctgct acaaagaatc tgtagatcaa     1740

agaggaaacc agataatgtc agacaagagg aatgtcatcc tgttttctgt atttgatgag     1800

aaccgaagct ggtacctcac agagaatata caacgctttc tccccaatcc agctggagtg     1860

cagcttgagg atccagagtt ccaagcctcc aacatcatgc acagcatcaa tggctatgtt     1920

tttgatagtt tgcagttgtc agtttgtttg catgaggtgg catactggta cattctaagc     1980

attggagcac agactgactt cctttctgtc ttcttctctg gatatacctt caaacacaaa     2040

atggtctatg aagacacact caccctattc ccattctcag gagaaactgt cttcatgtcg     2100

atggaaaacc caggtctatg gattctgggg tgccacaact cagactttcg gaacagaggc     2160

atgaccgcct tactgaaggt ttctagttgt gacaagaaca ctggtgatta ttacgaggac     2220

agttatgaag atatttcagc atacttgctg agtaaaaaca atgccattga accaagaagc     2280

ttctctcaaa acggtacctc agagtctgct acccccgagt cagggccagg atcagagcca     2340

gccacctccg ggtctgagac acccgggact tccgagagtg ccacccctga gtccggaccc     2400

gggtccgagc ccgccacttc cggctccgaa actcccggca caagcgagag cgctacccca     2460

gagtcaggac caggaacatc tacagagccc tctgaaggct ccgctccagg gtccccagcc     2520

ggcagtccca ctagcaccga ggagggaacc tctgaaagcg ccacacccga atcagggcca     2580

gggtctgagc ctgctaccag cggcagcgag acaccaggca cctctgagtc cgccacacca     2640

gagtccggac ccggatctcc cgctgggagc cccacctcca ctgaggaggg atctcctgct     2700

ggctctccaa catctactga ggaaggaacc tcaaccgagc catccgaggg atcagctccc     2760

ggcacctcag agtcggcaac cccggagtct ggacccggaa cttccgaaag tgccacacca     2820

gagtccggtc ccgggacttc agaatcagca acacccgagt ccggccctgg gtctgaaccc     2880

gccacaagtg gtagtgagac accaggatca gaacctgcta cctcagggtc agagacaccc     2940

ggatctccgg caggctcacc aacctccact gaggagggca ccagcacaga accaagcgag     3000

ggctccgcac ccggaacaag cactgaaccc agtgagggtt cagcacccgg ctctgagccg     3060

gccacaagtg gcagtgagac acccggcact tcagagagtg ccacccccga gagtggccca     3120

ggcactagta ccgagccctc tgaaggcagt gcgccagcct cgagcgaaat aactcgtact     3180

actcttcagt cagatcaaga ggaaattgac tatgatgata ccatatcagt tgaaatgaag     3240

aaggaagatt ttgacattta tgatgaggat gaaaatcaga gcccccgcag ctttcaaaag     3300

aaaacacgac actattttat tgctgcagtg gagaggctct gggattatgg gatgagtagc     3360

tccccacatg ttctaagaaa cagggctcag agtggcagtg tccctcagtt caagaaagtt     3420

gttttccagg aatttactga tggctccttt actcagccct tataccgtgg agaactaaat     3480

gaacatttgg gactcctggg gccatatata agagcagaag ttgaagataa tatcatggta     3540

actttcagaa atcaggcctc tcgtccctat tccttctatt ctagccttat ttcttatgag     3600

gaagatcaga ggcaaggagc agaacctaga aaaaactttg tcaagcctaa tgaaaccaaa     3660

acttactttt ggaaagtgca acatcatatg gcacccacta aagatgagtt tgactgcaaa     3720

gcctgggctt atttctctga tgttgacctg gaaaaagatg tgcactcagg cctgattgga     3780

ccccttctgg tctgccacac taacacactg aaccctgctc atgggagaca agtgacagta     3840

caggaatttg ctctgttttt caccatcttt gatgagacca aaagctggta cttcactgaa     3900

aatatggaaa gaaactgcag ggctccctgc aatatccaga tggaagatcc cacttttaaa     3960

gagaattatc gcttccatgc aatcaatggc tacataatgg atacactacc tggcttagta     4020

atggctcagg atcaaaggat tcgatggtat ctgctcagca tgggcagcaa tgaaaacatc     4080

cattctattc atttcagtgg acatgtgttc actgtacgaa aaaaagagga gtataaaatg     4140

gcactgtaca atctctatcc aggtgttttt gagacagtgg aaatgttacc atccaaagct     4200

ggaatttggc gggtggaatg ccttattggc gagcatctac atgctgggat gagcacactt     4260

tttctggtgt acagcaataa gtgtcagact cccctgggaa tggcttctgg acacattaga     4320

gattttcaga ttacagcttc aggacaatat ggacagtggg ccccaaagct ggccagactt     4380

cattattccg gatcaatcaa tgcctggagc accaaggagc ccttttcttg gatcaaggtg     4440

gatctgttgg caccaatgat tattcacggc atcaagaccc agggtgcccg tcagaagttc     4500

tccagcctct acatctctca gtttatcatc atgtatagtc ttgatgggaa gaagtggcag     4560

acttatcgag gaaattccac tggaacctta atggtcttct ttggcaatgt ggattcatct     4620

gggataaaac acaatatttt taaccctcca attattgctc gatacatccg tttgcaccca     4680

actcattata gcattcgcag cactcttcgc atggagttga tgggctgtga tttaaatagt     4740

tgcagcatgc cattgggaat ggagagtaaa gcaatatcag atgcacagat tactgcttca     4800

tcctacttta ccaatatgtt tgccacctgg tctccttcaa aagctcgact tcacctccaa     4860

gggaggagta atgcctggag acctcaggtg aataatccaa aagagtggct gcaagtggac     4920

ttccagaaga caatgaaagt cacaggagta actactcagg gagtaaaatc tctgcttacc     4980

agcatgtatg tgaaggagtt cctcatctcc agcagtcaag atggccatca gtggactctc     5040

ttttttcaga atggcaaagt aaaggttttt cagggaaatc aagactcctt cacacctgtg     5100

gtgaactctc tagacccacc gttactgact cgctaccttc gaattcaccc ccagagttgg     5160

gtgcaccaga ttgccctgag gatggaggtt ctgggctgcg aggcacagga cctctacgac     5220

aaaactcaca catgcccacc gtgcccagct ccagaactcc tgggcggacc gtcagtcttc     5280

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc     5340

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta tgtggacggc     5400

gtggaagtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt     5460

gtggtcagcg tcctcaccgt cctgcaccaa gactggctga atggcaagga gtacaagtgc     5520

aaggtctcca acaaagccct cccagccccc atcgagaaaa ccatctccaa agccaaaggg     5580

cagccccgag aaccacaggt gtacaccctg cccccatccc gggatgagct gaccaagaac     5640

caagttagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg     5700

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgtt ggactccgac     5760

ggctccttct tcctctactc caagctcacc gtggacaaga gcaggtggca gcaggggaac     5820

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc     5880

tccctgtctc cgggttga                                                   5898


<210>  5
<211>  1646
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  5

Met Ile Pro Ala Arg Phe Ala Gly Val Leu Leu Ala Leu Ala Leu Ile 
1               5                   10                  15      


Leu Pro Gly Thr Leu Cys Ala Glu Gly Thr Arg Gly Arg Ser Ser Thr 
            20                  25                  30          


Ala Arg Cys Ser Leu Phe Gly Ser Asp Phe Val Asn Thr Phe Asp Gly 
        35                  40                  45              


Ser Met Tyr Ser Phe Ala Gly Tyr Cys Ser Tyr Leu Leu Ala Gly Gly 
    50                  55                  60                  


Cys Gln Lys Arg Ser Phe Ser Ile Ile Gly Asp Phe Gln Asn Gly Lys 
65                  70                  75                  80  


Arg Val Ser Leu Ser Val Tyr Leu Gly Glu Phe Phe Asp Ile His Leu 
                85                  90                  95      


Phe Val Asn Gly Thr Val Thr Gln Gly Asp Gln Arg Val Ser Met Pro 
            100                 105                 110         


Tyr Ala Ser Lys Gly Leu Tyr Leu Glu Thr Glu Ala Gly Tyr Tyr Lys 
        115                 120                 125             


Leu Ser Gly Glu Ala Tyr Gly Phe Val Ala Arg Ile Asp Gly Ser Gly 
    130                 135                 140                 


Asn Phe Gln Val Leu Leu Ser Asp Arg Tyr Phe Asn Lys Thr Cys Gly 
145                 150                 155                 160 


Leu Cys Gly Asn Phe Asn Ile Phe Ala Glu Asp Asp Phe Met Thr Gln 
                165                 170                 175     


Glu Gly Thr Leu Thr Ser Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala 
            180                 185                 190         


Leu Ser Ser Gly Glu Gln Trp Cys Glu Arg Ala Ser Pro Pro Ser Ser 
        195                 200                 205             


Ser Cys Asn Ile Ser Ser Gly Glu Met Gln Lys Gly Leu Trp Glu Gln 
    210                 215                 220                 


Cys Gln Leu Leu Lys Ser Thr Ser Val Phe Ala Arg Cys His Pro Leu 
225                 230                 235                 240 


Val Asp Pro Glu Pro Phe Val Ala Leu Cys Glu Lys Thr Leu Cys Glu 
                245                 250                 255     


Cys Ala Gly Gly Leu Glu Cys Ala Cys Pro Ala Leu Leu Glu Tyr Ala 
            260                 265                 270         


Arg Thr Cys Ala Gln Glu Gly Met Val Leu Tyr Gly Trp Thr Asp His 
        275                 280                 285             


Ser Ala Cys Ser Pro Val Cys Pro Ala Gly Met Glu Tyr Arg Gln Cys 
    290                 295                 300                 


Val Ser Pro Cys Ala Arg Thr Cys Gln Ser Leu His Ile Asn Glu Met 
305                 310                 315                 320 


Cys Gln Glu Arg Cys Val Asp Gly Cys Ser Cys Pro Glu Gly Gln Leu 
                325                 330                 335     


Leu Asp Glu Gly Leu Cys Val Glu Ser Thr Glu Cys Pro Cys Val His 
            340                 345                 350         


Ser Gly Lys Arg Tyr Pro Pro Gly Thr Ser Leu Ser Arg Asp Cys Asn 
        355                 360                 365             


Thr Cys Ile Cys Arg Asn Ser Gln Trp Ile Cys Ser Asn Glu Glu Cys 
    370                 375                 380                 


Pro Gly Glu Cys Leu Val Thr Gly Gln Ser His Phe Lys Ser Phe Asp 
385                 390                 395                 400 


Asn Arg Tyr Phe Thr Phe Ser Gly Ile Cys Gln Tyr Leu Leu Ala Arg 
                405                 410                 415     


Asp Cys Gln Asp His Ser Phe Ser Ile Val Ile Glu Thr Val Gln Cys 
            420                 425                 430         


Ala Asp Asp Arg Asp Ala Val Cys Thr Arg Ser Val Thr Val Arg Leu 
        435                 440                 445             


Pro Gly Leu His Asn Ser Leu Val Lys Leu Lys His Gly Ala Gly Val 
    450                 455                 460                 


Ala Met Asp Gly Gln Asp Ile Gln Leu Pro Leu Leu Lys Gly Asp Leu 
465                 470                 475                 480 


Arg Ile Gln His Thr Val Thr Ala Ser Val Arg Leu Ser Tyr Gly Glu 
                485                 490                 495     


Asp Leu Gln Met Asp Trp Asp Gly Arg Gly Arg Leu Leu Val Lys Leu 
            500                 505                 510         


Ser Pro Val Tyr Ala Gly Lys Thr Cys Gly Leu Cys Gly Asn Tyr Asn 
        515                 520                 525             


Gly Asn Gln Gly Asp Asp Phe Leu Thr Pro Ser Gly Leu Ala Glu Pro 
    530                 535                 540                 


Arg Val Glu Asp Phe Gly Asn Ala Trp Lys Leu His Gly Asp Cys Gln 
545                 550                 555                 560 


Asp Leu Gln Lys Gln His Ser Asp Pro Cys Ala Leu Asn Pro Arg Met 
                565                 570                 575     


Thr Arg Phe Ser Glu Glu Ala Cys Ala Val Leu Thr Ser Pro Thr Phe 
            580                 585                 590         


Glu Ala Cys His Arg Ala Val Ser Pro Leu Pro Tyr Leu Arg Asn Cys 
        595                 600                 605             


Arg Tyr Asp Val Cys Ser Cys Ser Asp Gly Arg Glu Cys Leu Cys Gly 
    610                 615                 620                 


Ala Leu Ala Ser Tyr Ala Ala Ala Cys Ala Gly Arg Gly Val Arg Val 
625                 630                 635                 640 


Ala Trp Arg Glu Pro Gly Arg Cys Glu Leu Asn Cys Pro Lys Gly Gln 
                645                 650                 655     


Val Tyr Leu Gln Cys Gly Thr Pro Cys Asn Leu Thr Cys Arg Ser Leu 
            660                 665                 670         


Ser Tyr Pro Asp Glu Glu Cys Asn Glu Ala Cys Leu Glu Gly Cys Phe 
        675                 680                 685             


Cys Pro Pro Gly Leu Tyr Met Asp Glu Arg Gly Asp Cys Val Pro Lys 
    690                 695                 700                 


Ala Gln Cys Pro Cys Tyr Tyr Asp Gly Glu Ile Phe Gln Pro Glu Asp 
705                 710                 715                 720 


Ile Phe Ser Asp His His Thr Met Cys Tyr Cys Glu Asp Gly Phe Met 
                725                 730                 735     


His Cys Thr Met Ser Gly Val Pro Gly Ser Leu Leu Pro Asp Ala Val 
            740                 745                 750         


Leu Ser Ser Pro Leu Ser His Arg Ser Lys Arg Ser Leu Ser Cys Arg 
        755                 760                 765             


Pro Pro Met Val Lys Leu Val Cys Pro Ala Asp Asn Leu Arg Ala Glu 
    770                 775                 780                 


Gly Leu Glu Cys Thr Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Met 
785                 790                 795                 800 


Ser Met Gly Cys Val Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg 
                805                 810                 815     


His Glu Asn Arg Cys Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln 
            820                 825                 830         


Gly Lys Glu Tyr Ala Pro Gly Glu Thr Val Lys Ile Gly Cys Asn Thr 
        835                 840                 845             


Cys Val Cys Arg Asp Arg Lys Trp Asn Cys Thr Asp His Val Cys Asp 
    850                 855                 860                 


Ala Thr Cys Ser Thr Ile Gly Met Ala His Tyr Leu Thr Phe Asp Gly 
865                 870                 875                 880 


Leu Lys Tyr Leu Phe Pro Gly Glu Cys Gln Tyr Val Leu Val Gln Asp 
                885                 890                 895     


Tyr Cys Gly Ser Asn Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Lys 
            900                 905                 910         


Gly Cys Ser His Pro Ser Val Lys Cys Lys Lys Arg Val Thr Ile Leu 
        915                 920                 925             


Val Glu Gly Gly Glu Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys 
    930                 935                 940                 


Arg Pro Met Lys Asp Glu Thr His Phe Glu Val Val Glu Ser Gly Arg 
945                 950                 955                 960 


Tyr Ile Ile Leu Leu Leu Gly Lys Ala Leu Ser Val Val Trp Asp Arg 
                965                 970                 975     


His Leu Ser Ile Ser Val Val Leu Lys Gln Thr Tyr Gln Glu Lys Val 
            980                 985                 990         


Cys Gly Leu Cys Gly Asn Phe Asp  Gly Ile Gln Asn Asn  Asp Leu Thr 
        995                 1000                 1005             


Ser Ser  Asn Leu Gln Val Glu  Glu Asp Pro Val Asp  Phe Gly Asn 
    1010                 1015                 1020             


Ser Trp  Lys Val Ser Ser Gln  Cys Ala Asp Thr Arg  Lys Val Pro 
    1025                 1030                 1035             


Leu Asp  Ser Ser Pro Ala Thr  Cys His Asn Asn Ile  Met Lys Gln 
    1040                 1045                 1050             


Thr Met  Val Asp Ser Ser Cys  Arg Ile Leu Thr Ser  Asp Val Phe 
    1055                 1060                 1065             


Gln Asp  Cys Asn Lys Leu Val  Asp Pro Glu Pro Tyr  Leu Asp Val 
    1070                 1075                 1080             


Cys Ile  Tyr Asp Thr Cys Ser  Cys Glu Ser Ile Gly  Asp Cys Ala 
    1085                 1090                 1095             


Ala Phe  Cys Asp Thr Ile Ala  Ala Tyr Ala His Val  Cys Ala Gln 
    1100                 1105                 1110             


His Gly  Lys Val Val Thr Trp  Arg Thr Ala Thr Leu  Cys Pro Gln 
    1115                 1120                 1125             


Ser Cys  Glu Glu Arg Asn Leu  Arg Glu Asn Gly Tyr  Glu Ala Glu 
    1130                 1135                 1140             


Trp Arg  Tyr Asn Ser Cys Ala  Pro Ala Cys Gln Val  Thr Cys Gln 
    1145                 1150                 1155             


His Pro  Glu Pro Leu Ala Cys  Pro Val Gln Cys Val  Glu Gly Cys 
    1160                 1165                 1170             


His Ala  His Cys Pro Pro Gly  Lys Ile Leu Asp Glu  Leu Leu Gln 
    1175                 1180                 1185             


Thr Cys  Val Asp Pro Glu Asp  Cys Pro Val Cys Glu  Val Ala Gly 
    1190                 1195                 1200             


Arg Arg  Phe Ala Ser Gly Lys  Lys Val Thr Leu Asn  Pro Ser Asp 
    1205                 1210                 1215             


Pro Glu  His Cys Gln Ile Cys  His Cys Asp Val Val  Asn Leu Thr 
    1220                 1225                 1230             


Cys Glu  Ala Cys Gln Glu Pro  Gly Thr Ser Glu Ser  Ala Thr Pro 
    1235                 1240                 1245             


Glu Ser  Gly Pro Gly Ser Glu  Pro Ala Thr Ser Gly  Ser Glu Thr 
    1250                 1255                 1260             


Pro Gly  Thr Ser Glu Ser Ala  Thr Pro Glu Ser Gly  Pro Gly Ser 
    1265                 1270                 1275             


Glu Pro  Ala Thr Ser Gly Ser  Glu Thr Pro Gly Thr  Ser Glu Ser 
    1280                 1285                 1290             


Ala Thr  Pro Glu Ser Gly Pro  Gly Thr Ser Thr Glu  Pro Ser Glu 
    1295                 1300                 1305             


Gly Ser  Ala Pro Gly Ser Pro  Ala Gly Ser Pro Thr  Ser Thr Glu 
    1310                 1315                 1320             


Glu Gly  Thr Ser Glu Ser Ala  Thr Pro Glu Ser Gly  Pro Gly Ser 
    1325                 1330                 1335             


Glu Pro  Ala Thr Ser Gly Ser  Glu Thr Pro Gly Thr  Ser Glu Ser 
    1340                 1345                 1350             


Ala Thr  Pro Glu Ser Gly Pro  Gly Ser Pro Ala Gly  Ser Pro Thr 
    1355                 1360                 1365             


Ser Thr  Glu Glu Gly Ser Pro  Ala Gly Ser Pro Thr  Ser Thr Glu 
    1370                 1375                 1380             


Glu Gly  Ala Ser Ser Asp Lys  Asn Thr Gly Asp Tyr  Tyr Glu Asp 
    1385                 1390                 1395             


Ser Tyr  Glu Asp Ile Ser Ala  Tyr Leu Leu Ser Lys  Asn Asn Ala 
    1400                 1405                 1410             


Ile Glu  Pro Arg Ser Phe Ser  Asp Lys Thr His Thr  Cys Pro Pro 
    1415                 1420                 1425             


Cys Pro  Ala Pro Glu Leu Leu  Gly Gly Pro Ser Val  Phe Leu Phe 
    1430                 1435                 1440             


Pro Pro  Lys Pro Lys Asp Thr  Leu Met Ile Ser Arg  Thr Pro Glu 
    1445                 1450                 1455             


Val Thr  Cys Val Val Val Asp  Val Ser His Glu Asp  Pro Glu Val 
    1460                 1465                 1470             


Lys Phe  Asn Trp Tyr Val Asp  Gly Val Glu Val His  Asn Ala Lys 
    1475                 1480                 1485             


Thr Lys  Pro Arg Glu Glu Gln  Tyr Asn Ser Thr Tyr  Arg Val Val 
    1490                 1495                 1500             


Ser Val  Leu Thr Val Leu His  Gln Asp Trp Leu Asn  Gly Lys Glu 
    1505                 1510                 1515             


Tyr Lys  Cys Lys Val Ser Asn  Lys Ala Leu Pro Ala  Pro Ile Glu 
    1520                 1525                 1530             


Lys Thr  Ile Ser Lys Ala Lys  Gly Gln Pro Arg Glu  Pro Gln Val 
    1535                 1540                 1545             


Tyr Thr  Leu Pro Pro Ser Arg  Asp Glu Leu Thr Lys  Asn Gln Val 
    1550                 1555                 1560             


Ser Leu  Thr Cys Leu Val Lys  Gly Phe Tyr Pro Ser  Asp Ile Ala 
    1565                 1570                 1575             


Val Glu  Trp Glu Ser Asn Gly  Gln Pro Glu Asn Asn  Tyr Lys Thr 
    1580                 1585                 1590             


Thr Pro  Pro Val Leu Asp Ser  Asp Gly Ser Phe Phe  Leu Tyr Ser 
    1595                 1600                 1605             


Lys Leu  Thr Val Asp Lys Ser  Arg Trp Gln Gln Gly  Asn Val Phe 
    1610                 1615                 1620             


Ser Cys  Ser Val Met His Glu  Ala Leu His Asn His  Tyr Thr Gln 
    1625                 1630                 1635             


Lys Ser  Leu Ser Leu Ser Pro  Gly 
    1640                 1645     


<210>  6
<211>  4941
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  6
atgattcctg ccagatttgc cggggtgctg cttgctctgg ccctcatttt gccagggacc       60

ctttgtgcag aaggaactcg cggcaggtca tccacggccc gatgcagcct tttcggaagt      120

gacttcgtca acacctttga tgggagcatg tacagctttg cgggatactg cagttacctc      180

ctggcagggg gctgccagaa acgctccttc tcgattattg gggacttcca gaatggcaag      240

agagtgagcc tctccgtgta tcttggggaa ttttttgaca tccatttgtt tgtcaatggt      300

accgtgacac agggggacca aagagtctcc atgccctatg cctccaaagg gctgtatcta      360

gaaactgagg ctgggtacta caagctgtcc ggtgaggcct atggctttgt ggccaggatc      420

gatggcagcg gcaactttca agtcctgctg tcagacagat acttcaacaa gacctgcggg      480

ctgtgtggca actttaacat ctttgctgaa gatgacttta tgacccaaga agggaccttg      540

acctcggacc cttatgactt tgccaactca tgggctctga gcagtggaga acagtggtgt      600

gaacgggcat ctcctcccag cagctcatgc aacatctcct ctggggaaat gcagaagggc      660

ctgtgggagc agtgccagct tctgaagagc acctcggtgt ttgcccgctg ccaccctctg      720

gtggaccccg agccttttgt ggccctgtgt gagaagactt tgtgtgagtg tgctgggggg      780

ctggagtgcg cctgccctgc cctcctggag tacgcccgga cctgtgccca ggagggaatg      840

gtgctgtacg gctggaccga ccacagcgcg tgcagcccag tgtgccctgc tggtatggag      900

tataggcagt gtgtgtcccc ttgcgccagg acctgccaga gcctgcacat caatgaaatg      960

tgtcaggagc gatgcgtgga tggctgcagc tgccctgagg gacagctcct ggatgaaggc     1020

ctctgcgtgg agagcaccga gtgtccctgc gtgcattccg gaaagcgcta ccctcccggc     1080

acctccctct ctcgagactg caacacctgc atttgccgaa acagccagtg gatctgcagc     1140

aatgaagaat gtccagggga gtgccttgtc actggtcaat cccacttcaa gagctttgac     1200

aacagatact tcaccttcag tgggatctgc cagtacctgc tggcccggga ttgccaggac     1260

cactccttct ccattgtcat tgagactgtc cagtgtgctg atgaccgcga cgctgtgtgc     1320

acccgctccg tcaccgtccg gctgcctggc ctgcacaaca gccttgtgaa actgaagcat     1380

ggggcaggag ttgccatgga tggccaggac atccagctcc ccctcctgaa aggtgacctc     1440

cgcatccagc atacagtgac ggcctccgtg cgcctcagct acggggagga cctgcagatg     1500

gactgggatg gccgcgggag gctgctggtg aagctgtccc ccgtctatgc cgggaagacc     1560

tgcggcctgt gtgggaatta caatggcaac cagggcgacg acttccttac cccctctggg     1620

ctggcggagc cccgggtgga ggacttcggg aacgcctgga agctgcacgg ggactgccag     1680

gacctgcaga agcagcacag cgatccctgc gccctcaacc cgcgcatgac caggttctcc     1740

gaggaggcgt gcgcggtcct gacgtccccc acattcgagg cctgccatcg tgccgtcagc     1800

ccgctgccct acctgcggaa ctgccgctac gacgtgtgct cctgctcgga cggccgcgag     1860

tgcctgtgcg gcgccctggc cagctatgcc gcggcctgcg cggggagagg cgtgcgcgtc     1920

gcgtggcgcg agccaggccg ctgtgagctg aactgcccga aaggccaggt gtacctgcag     1980

tgcgggaccc cctgcaacct gacctgccgc tctctctctt acccggatga ggaatgcaat     2040

gaggcctgcc tggagggctg cttctgcccc ccagggctct acatggatga gaggggggac     2100

tgcgtgccca aggcccagtg cccctgttac tatgacggtg agatcttcca gccagaagac     2160

atcttctcag accatcacac catgtgctac tgtgaggatg gcttcatgca ctgtaccatg     2220

agtggagtcc ccggaagctt gctgcctgac gctgtcctca gcagtcccct gtctcatcgc     2280

agcaaaagga gcctatcctg tcggcccccc atggtcaagc tggtgtgtcc cgctgacaac     2340

ctgcgggctg aagggctcga gtgtaccaaa acgtgccaga actatgacct ggagtgcatg     2400

agcatgggct gtgtctctgg ctgcctctgc cccccgggca tggtccggca tgagaacaga     2460

tgtgtggccc tggaaaggtg tccctgcttc catcagggca aggagtatgc ccctggagaa     2520

acagtgaaga ttggctgcaa cacttgtgtc tgtcgggacc ggaagtggaa ctgcacagac     2580

catgtgtgtg atgccacgtg ctccacgatc ggcatggccc actacctcac cttcgacggg     2640

ctcaaatacc tgttccccgg ggagtgccag tacgttctgg tgcaggatta ctgcggcagt     2700

aaccctggga cctttcggat cctagtgggg aataagggat gcagccaccc ctcagtgaaa     2760

tgcaagaaac gggtcaccat cctggtggag ggaggagaga ttgagctgtt tgacggggag     2820

gtgaatgtga agaggcccat gaaggatgag actcactttg aggtggtgga gtctggccgg     2880

tacatcattc tgctgctggg caaagccctc tccgtggtct gggaccgcca cctgagcatc     2940

tccgtggtcc tgaagcagac ataccaggag aaagtgtgtg gcctgtgtgg gaattttgat     3000

ggcatccaga acaatgacct caccagcagc aacctccaag tggaggaaga ccctgtggac     3060

tttgggaact cctggaaagt gagctcgcag tgtgctgaca ccagaaaagt gcctctggac     3120

tcatcccctg ccacctgcca taacaacatc atgaagcaga cgatggtgga ttcctcctgt     3180

agaatcctta ccagtgacgt cttccaggac tgcaacaagc tggtggaccc cgagccatat     3240

ctggatgtct gcatttacga cacctgctcc tgtgagtcca ttggggactg cgccgcattc     3300

tgcgacacca ttgctgccta tgcccacgtg tgtgcccagc atggcaaggt ggtgacctgg     3360

aggacggcca cattgtgccc ccagagctgc gaggagagga atctccggga gaacgggtat     3420

gaggctgagt ggcgctataa cagctgtgca cctgcctgtc aagtcacgtg tcagcaccct     3480

gagccactgg cctgccctgt gcagtgtgtg gagggctgcc atgcccactg ccctccaggg     3540

aaaatcctgg atgagctttt gcagacctgc gttgaccctg aagactgtcc agtgtgtgag     3600

gtggctggcc ggcgttttgc ctcaggaaag aaagtcacct tgaatcccag tgaccctgag     3660

cactgccaga tttgccactg tgatgttgtc aacctcacct gtgaagcctg ccaggagccg     3720

ggtacatcag agagcgccac ccctgaaagt ggtcccggga gcgagccagc cacatctggg     3780

tcggaaacgc caggcacatc cgagtctgca actcccgagt ccggacctgg ctccgagcct     3840

gccactagcg gctccgagac tccgggaact tccgagagcg ctacaccaga aagcggaccc     3900

ggaaccagta ccgaacctag cgagggctct gctccgggca gcccagccgg ctctcctaca     3960

tccacggagg agggcacttc cgaatccgcc accccggagt cagggccagg atctgaaccc     4020

gctacctcag gcagtgagac gccaggaacg agcgagtccg ctacaccgga gagtgggcca     4080

gggagccctg ctggatctcc tacgtccact gaggaagggt caccagcggg ctcgcccacc     4140

agcactgaag aaggtgcctc gtctgacaag aacactggtg attattacga ggacagttat     4200

gaagatattt cagcatactt gctgagtaaa aacaatgcca ttgaaccaag aagcttctct     4260

gacaaaactc acacatgccc accgtgccca gctccagaac tcctgggcgg accgtcagtc     4320

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca     4380

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtatgtggac     4440

ggcgtggaag tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac     4500

cgtgtggtca gcgtcctcac cgtcctgcac caagactggc tgaatggcaa ggagtacaag     4560

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa     4620

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggatga gctgaccaag     4680

aaccaagtta gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag     4740

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gttggactcc     4800

gacggctcct tcttcctcta ctccaagctc accgtggaca agagcaggtg gcagcagggg     4860

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc     4920

ctctccctgt ctccgggttg a                                               4941


<210>  7
<211>  1945
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  7

Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr Met 
1               5                   10                  15      


Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro Arg 
            20                  25                  30          


Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys Thr 
        35                  40                  45              


Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro Arg 
    50                  55                  60                  


Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val Tyr 
65                  70                  75                  80  


Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val Ser 
                85                  90                  95      


Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala Glu 
            100                 105                 110         


Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val Phe 
        115                 120                 125             


Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn Gly 
    130                 135                 140                 


Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser His 
145                 150                 155                 160 


Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu Leu 
                165                 170                 175     


Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu His 
            180                 185                 190         


Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp His 
        195                 200                 205             


Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser Ala 
    210                 215                 220                 


Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg Ser 
225                 230                 235                 240 


Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His Val 
                245                 250                 255     


Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu Gly 
            260                 265                 270         


His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile Ser 
        275                 280                 285             


Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly Gln 
    290                 295                 300                 


Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met Glu 
305                 310                 315                 320 


Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg Met 
                325                 330                 335     


Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp Ser 
            340                 345                 350         


Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe Ile 
        355                 360                 365             


Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His Tyr 
    370                 375                 380                 


Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu Ala 
385                 390                 395                 400 


Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro Gln 
                405                 410                 415     


Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr Asp 
            420                 425                 430         


Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile Leu 
        435                 440                 445             


Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile Phe 
    450                 455                 460                 


Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile Thr 
465                 470                 475                 480 


Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys His 
                485                 490                 495     


Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys Trp 
            500                 505                 510         


Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys Leu 
        515                 520                 525             


Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala Ser 
    530                 535                 540                 


Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp Gln 
545                 550                 555                 560 


Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu Phe Ser 
                565                 570                 575     


Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln Arg 
            580                 585                 590         


Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp Pro Glu Phe Gln 
        595                 600                 605             


Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser Leu 
    610                 615                 620                 


Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu Ser 
625                 630                 635                 640 


Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr Thr 
                645                 650                 655     


Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro Phe 
            660                 665                 670         


Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp Ile 
        675                 680                 685             


Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala Leu 
    690                 695                 700                 


Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu Asp 
705                 710                 715                 720 


Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala Ile 
                725                 730                 735     


Glu Pro Arg Ser Phe Ser Gln Asn Gly Thr Ser Glu Ser Ala Thr Pro 
            740                 745                 750         


Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 
        755                 760                 765             


Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro 
    770                 775                 780                 


Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 
785                 790                 795                 800 


Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 
                805                 810                 815     


Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu 
            820                 825                 830         


Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly 
        835                 840                 845             


Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 
    850                 855                 860                 


Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala 
865                 870                 875                 880 


Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu 
                885                 890                 895     


Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 
            900                 905                 910         


Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu 
        915                 920                 925             


Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly 
    930                 935                 940                 


Ser Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 
945                 950                 955                 960 


Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr 
                965                 970                 975     


Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu 
            980                 985                 990         


Gly Ser Ala Pro Gly Ser Glu Pro  Ala Thr Ser Gly Ser  Glu Thr Pro 
        995                 1000                 1005             


Gly Thr  Ser Glu Ser Ala Thr  Pro Glu Ser Gly Pro  Gly Thr Ser 
    1010                 1015                 1020             


Thr Glu  Pro Ser Glu Gly Ser  Ala Pro Ala Ser Ser  Glu Ile Thr 
    1025                 1030                 1035             


Arg Thr  Thr Leu Gln Ser Asp  Gln Glu Glu Ile Asp  Tyr Asp Asp 
    1040                 1045                 1050             


Thr Ile  Ser Val Glu Met Lys  Lys Glu Asp Phe Asp  Ile Tyr Asp 
    1055                 1060                 1065             


Glu Asp  Glu Asn Gln Ser Pro  Arg Ser Phe Gln Lys  Lys Thr Arg 
    1070                 1075                 1080             


His Tyr  Phe Ile Ala Ala Val  Glu Arg Leu Trp Asp  Tyr Gly Met 
    1085                 1090                 1095             


Ser Ser  Ser Pro His Val Leu  Arg Asn Arg Ala Gln  Ser Gly Ser 
    1100                 1105                 1110             


Val Pro  Gln Phe Lys Lys Val  Val Phe Gln Glu Phe  Thr Asp Gly 
    1115                 1120                 1125             


Ser Phe  Thr Gln Pro Leu Tyr  Arg Gly Glu Leu Asn  Glu His Leu 
    1130                 1135                 1140             


Gly Leu  Leu Gly Pro Tyr Ile  Arg Ala Glu Val Glu  Asp Asn Ile 
    1145                 1150                 1155             


Met Val  Thr Phe Arg Asn Gln  Ala Ser Arg Pro Tyr  Ser Phe Tyr 
    1160                 1165                 1170             


Ser Ser  Leu Ile Ser Tyr Glu  Glu Asp Gln Arg Gln  Gly Ala Glu 
    1175                 1180                 1185             


Pro Arg  Lys Asn Phe Val Lys  Pro Asn Glu Thr Lys  Thr Tyr Phe 
    1190                 1195                 1200             


Trp Lys  Val Gln His His Met  Ala Pro Thr Lys Asp  Glu Phe Asp 
    1205                 1210                 1215             


Cys Lys  Ala Trp Ala Tyr Phe  Ser Asp Val Asp Leu  Glu Lys Asp 
    1220                 1225                 1230             


Val His  Ser Gly Leu Ile Gly  Pro Leu Leu Val Cys  His Thr Asn 
    1235                 1240                 1245             


Thr Leu  Asn Pro Ala His Gly  Arg Gln Val Thr Val  Gln Glu Phe 
    1250                 1255                 1260             


Ala Leu  Phe Phe Thr Ile Phe  Asp Glu Thr Lys Ser  Trp Tyr Phe 
    1265                 1270                 1275             


Thr Glu  Asn Met Glu Arg Asn  Cys Arg Ala Pro Cys  Asn Ile Gln 
    1280                 1285                 1290             


Met Glu  Asp Pro Thr Phe Lys  Glu Asn Tyr Arg Phe  His Ala Ile 
    1295                 1300                 1305             


Asn Gly  Tyr Ile Met Asp Thr  Leu Pro Gly Leu Val  Met Ala Gln 
    1310                 1315                 1320             


Asp Gln  Arg Ile Arg Trp Tyr  Leu Leu Ser Met Gly  Ser Asn Glu 
    1325                 1330                 1335             


Asn Ile  His Ser Ile His Phe  Ser Gly His Val Phe  Thr Val Arg 
    1340                 1345                 1350             


Lys Lys  Glu Glu Tyr Lys Met  Ala Leu Tyr Asn Leu  Tyr Pro Gly 
    1355                 1360                 1365             


Val Phe  Glu Thr Val Glu Met  Leu Pro Ser Lys Ala  Gly Ile Trp 
    1370                 1375                 1380             


Arg Val  Glu Cys Leu Ile Gly  Glu His Leu His Ala  Gly Met Ser 
    1385                 1390                 1395             


Thr Leu  Phe Leu Val Tyr Ser  Asn Lys Cys Gln Thr  Pro Leu Gly 
    1400                 1405                 1410             


Met Ala  Ser Gly His Ile Arg  Asp Phe Gln Ile Thr  Ala Ser Gly 
    1415                 1420                 1425             


Gln Tyr  Gly Gln Trp Ala Pro  Lys Leu Ala Arg Leu  His Tyr Ser 
    1430                 1435                 1440             


Gly Ser  Ile Asn Ala Trp Ser  Thr Lys Glu Pro Phe  Ser Trp Ile 
    1445                 1450                 1455             


Lys Val  Asp Leu Leu Ala Pro  Met Ile Ile His Gly  Ile Lys Thr 
    1460                 1465                 1470             


Gln Gly  Ala Arg Gln Lys Phe  Ser Ser Leu Tyr Ile  Ser Gln Phe 
    1475                 1480                 1485             


Ile Ile  Met Tyr Ser Leu Asp  Gly Lys Lys Trp Gln  Thr Tyr Arg 
    1490                 1495                 1500             


Gly Asn  Ser Thr Gly Thr Leu  Met Val Phe Phe Gly  Asn Val Asp 
    1505                 1510                 1515             


Ser Ser  Gly Ile Lys His Asn  Ile Phe Asn Pro Pro  Ile Ile Ala 
    1520                 1525                 1530             


Arg Tyr  Ile Arg Leu His Pro  Thr His Tyr Ser Ile  Arg Ser Thr 
    1535                 1540                 1545             


Leu Arg  Met Glu Leu Met Gly  Cys Asp Leu Asn Ser  Cys Ser Met 
    1550                 1555                 1560             


Pro Leu  Gly Met Glu Ser Lys  Ala Ile Ser Asp Ala  Gln Ile Thr 
    1565                 1570                 1575             


Ala Ser  Ser Tyr Phe Thr Asn  Met Phe Ala Thr Trp  Ser Pro Ser 
    1580                 1585                 1590             


Lys Ala  Arg Leu His Leu Gln  Gly Arg Ser Asn Ala  Trp Arg Pro 
    1595                 1600                 1605             


Gln Val  Asn Asn Pro Lys Glu  Trp Leu Gln Val Asp  Phe Gln Lys 
    1610                 1615                 1620             


Thr Met  Lys Val Thr Gly Val  Thr Thr Gln Gly Val  Lys Ser Leu 
    1625                 1630                 1635             


Leu Thr  Ser Met Tyr Val Lys  Glu Phe Leu Ile Ser  Ser Ser Gln 
    1640                 1645                 1650             


Asp Gly  His Gln Trp Thr Leu  Phe Phe Gln Asn Gly  Lys Val Lys 
    1655                 1660                 1665             


Val Phe  Gln Gly Asn Gln Asp  Ser Phe Thr Pro Val  Val Asn Ser 
    1670                 1675                 1680             


Leu Asp  Pro Pro Leu Leu Thr  Arg Tyr Leu Arg Ile  His Pro Gln 
    1685                 1690                 1695             


Ser Trp  Val His Gln Ile Ala  Leu Arg Met Glu Val  Leu Gly Cys 
    1700                 1705                 1710             


Glu Ala  Gln Asp Leu Tyr Asp  Lys Thr His Thr Cys  Pro Pro Cys 
    1715                 1720                 1725             


Pro Ala  Pro Glu Leu Leu Gly  Gly Pro Ser Val Phe  Leu Phe Pro 
    1730                 1735                 1740             


Pro Lys  Pro Lys Asp Thr Leu  Met Ile Ser Arg Thr  Pro Glu Val 
    1745                 1750                 1755             


Thr Cys  Val Val Val Asp Val  Ser His Glu Asp Pro  Glu Val Lys 
    1760                 1765                 1770             


Phe Asn  Trp Tyr Val Asp Gly  Val Glu Val His Asn  Ala Lys Thr 
    1775                 1780                 1785             


Lys Pro  Arg Glu Glu Gln Tyr  Asn Ser Thr Tyr Arg  Val Val Ser 
    1790                 1795                 1800             


Val Leu  Thr Val Leu His Gln  Asp Trp Leu Asn Gly  Lys Glu Tyr 
    1805                 1810                 1815             


Lys Cys  Lys Val Ser Asn Lys  Ala Leu Pro Ala Pro  Ile Glu Lys 
    1820                 1825                 1830             


Thr Ile  Ser Lys Ala Lys Gly  Gln Pro Arg Glu Pro  Gln Val Tyr 
    1835                 1840                 1845             


Thr Leu  Pro Pro Ser Arg Asp  Glu Leu Thr Lys Asn  Gln Val Ser 
    1850                 1855                 1860             


Leu Thr  Cys Leu Val Lys Gly  Phe Tyr Pro Ser Asp  Ile Ala Val 
    1865                 1870                 1875             


Glu Trp  Glu Ser Asn Gly Gln  Pro Glu Asn Asn Tyr  Lys Thr Thr 
    1880                 1885                 1890             


Pro Pro  Val Leu Asp Ser Asp  Gly Ser Phe Phe Leu  Tyr Ser Lys 
    1895                 1900                 1905             


Leu Thr  Val Asp Lys Ser Arg  Trp Gln Gln Gly Asn  Val Phe Ser 
    1910                 1915                 1920             


Cys Ser  Val Met His Glu Ala  Leu His Asn His Tyr  Thr Gln Lys 
    1925                 1930                 1935             


Ser Leu  Ser Leu Ser Pro Gly  
    1940                 1945 


<210>  8
<211>  2332
<212>  PRT
<213>  Homo sapiens

<400>  8

Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 
1               5                   10                  15      


Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 
            20                  25                  30          


Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 
        35                  40                  45              


Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro 
    50                  55                  60                  


Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val 
65                  70                  75                  80  


Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 
                85                  90                  95      


Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 
            100                 105                 110         


Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val 
        115                 120                 125             


Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn 
    130                 135                 140                 


Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser 
145                 150                 155                 160 


His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 
                165                 170                 175     


Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu 
            180                 185                 190         


His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp 
        195                 200                 205             


His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser 
    210                 215                 220                 


Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg 
225                 230                 235                 240 


Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His 
                245                 250                 255     


Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu 
            260                 265                 270         


Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 
        275                 280                 285             


Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly 
    290                 295                 300                 


Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met 
305                 310                 315                 320 


Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg 
                325                 330                 335     


Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp 
            340                 345                 350         


Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe 
        355                 360                 365             


Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His 
    370                 375                 380                 


Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu 
385                 390                 395                 400 


Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro 
                405                 410                 415     


Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr 
            420                 425                 430         


Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile 
        435                 440                 445             


Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile 
    450                 455                 460                 


Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile 
465                 470                 475                 480 


Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys 
                485                 490                 495     


His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys 
            500                 505                 510         


Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys 
        515                 520                 525             


Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala 
    530                 535                 540                 


Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp 
545                 550                 555                 560 


Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu Phe 
                565                 570                 575     


Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln 
            580                 585                 590         


Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp Pro Glu Phe 
        595                 600                 605             


Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser 
    610                 615                 620                 


Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu 
625                 630                 635                 640 


Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr 
                645                 650                 655     


Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro 
            660                 665                 670         


Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp 
        675                 680                 685             


Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala 
    690                 695                 700                 


Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu 
705                 710                 715                 720 


Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala 
                725                 730                 735     


Ile Glu Pro Arg Ser Phe Ser Gln Asn Ser Arg His Pro Ser Thr Arg 
            740                 745                 750         


Gln Lys Gln Phe Asn Ala Thr Thr Ile Pro Glu Asn Asp Ile Glu Lys 
        755                 760                 765             


Thr Asp Pro Trp Phe Ala His Arg Thr Pro Met Pro Lys Ile Gln Asn 
    770                 775                 780                 


Val Ser Ser Ser Asp Leu Leu Met Leu Leu Arg Gln Ser Pro Thr Pro 
785                 790                 795                 800 


His Gly Leu Ser Leu Ser Asp Leu Gln Glu Ala Lys Tyr Glu Thr Phe 
                805                 810                 815     


Ser Asp Asp Pro Ser Pro Gly Ala Ile Asp Ser Asn Asn Ser Leu Ser 
            820                 825                 830         


Glu Met Thr His Phe Arg Pro Gln Leu His His Ser Gly Asp Met Val 
        835                 840                 845             


Phe Thr Pro Glu Ser Gly Leu Gln Leu Arg Leu Asn Glu Lys Leu Gly 
    850                 855                 860                 


Thr Thr Ala Ala Thr Glu Leu Lys Lys Leu Asp Phe Lys Val Ser Ser 
865                 870                 875                 880 


Thr Ser Asn Asn Leu Ile Ser Thr Ile Pro Ser Asp Asn Leu Ala Ala 
                885                 890                 895     


Gly Thr Asp Asn Thr Ser Ser Leu Gly Pro Pro Ser Met Pro Val His 
            900                 905                 910         


Tyr Asp Ser Gln Leu Asp Thr Thr Leu Phe Gly Lys Lys Ser Ser Pro 
        915                 920                 925             


Leu Thr Glu Ser Gly Gly Pro Leu Ser Leu Ser Glu Glu Asn Asn Asp 
    930                 935                 940                 


Ser Lys Leu Leu Glu Ser Gly Leu Met Asn Ser Gln Glu Ser Ser Trp 
945                 950                 955                 960 


Gly Lys Asn Val Ser Ser Thr Glu Ser Gly Arg Leu Phe Lys Gly Lys 
                965                 970                 975     


Arg Ala His Gly Pro Ala Leu Leu Thr Lys Asp Asn Ala Leu Phe Lys 
            980                 985                 990         


Val Ser Ile Ser Leu Leu Lys Thr  Asn Lys Thr Ser Asn  Asn Ser Ala 
        995                 1000                 1005             


Thr Asn  Arg Lys Thr His Ile  Asp Gly Pro Ser Leu  Leu Ile Glu 
    1010                 1015                 1020             


Asn Ser  Pro Ser Val Trp Gln  Asn Ile Leu Glu Ser  Asp Thr Glu 
    1025                 1030                 1035             


Phe Lys  Lys Val Thr Pro Leu  Ile His Asp Arg Met  Leu Met Asp 
    1040                 1045                 1050             


Lys Asn  Ala Thr Ala Leu Arg  Leu Asn His Met Ser  Asn Lys Thr 
    1055                 1060                 1065             


Thr Ser  Ser Lys Asn Met Glu  Met Val Gln Gln Lys  Lys Glu Gly 
    1070                 1075                 1080             


Pro Ile  Pro Pro Asp Ala Gln  Asn Pro Asp Met Ser  Phe Phe Lys 
    1085                 1090                 1095             


Met Leu  Phe Leu Pro Glu Ser  Ala Arg Trp Ile Gln  Arg Thr His 
    1100                 1105                 1110             


Gly Lys  Asn Ser Leu Asn Ser  Gly Gln Gly Pro Ser  Pro Lys Gln 
    1115                 1120                 1125             


Leu Val  Ser Leu Gly Pro Glu  Lys Ser Val Glu Gly  Gln Asn Phe 
    1130                 1135                 1140             


Leu Ser  Glu Lys Asn Lys Val  Val Val Gly Lys Gly  Glu Phe Thr 
    1145                 1150                 1155             


Lys Asp  Val Gly Leu Lys Glu  Met Val Phe Pro Ser  Ser Arg Asn 
    1160                 1165                 1170             


Leu Phe  Leu Thr Asn Leu Asp  Asn Leu His Glu Asn  Asn Thr His 
    1175                 1180                 1185             


Asn Gln  Glu Lys Lys Ile Gln  Glu Glu Ile Glu Lys  Lys Glu Thr 
    1190                 1195                 1200             


Leu Ile  Gln Glu Asn Val Val  Leu Pro Gln Ile His  Thr Val Thr 
    1205                 1210                 1215             


Gly Thr  Lys Asn Phe Met Lys  Asn Leu Phe Leu Leu  Ser Thr Arg 
    1220                 1225                 1230             


Gln Asn  Val Glu Gly Ser Tyr  Asp Gly Ala Tyr Ala  Pro Val Leu 
    1235                 1240                 1245             


Gln Asp  Phe Arg Ser Leu Asn  Asp Ser Thr Asn Arg  Thr Lys Lys 
    1250                 1255                 1260             


His Thr  Ala His Phe Ser Lys  Lys Gly Glu Glu Glu  Asn Leu Glu 
    1265                 1270                 1275             


Gly Leu  Gly Asn Gln Thr Lys  Gln Ile Val Glu Lys  Tyr Ala Cys 
    1280                 1285                 1290             


Thr Thr  Arg Ile Ser Pro Asn  Thr Ser Gln Gln Asn  Phe Val Thr 
    1295                 1300                 1305             


Gln Arg  Ser Lys Arg Ala Leu  Lys Gln Phe Arg Leu  Pro Leu Glu 
    1310                 1315                 1320             


Glu Thr  Glu Leu Glu Lys Arg  Ile Ile Val Asp Asp  Thr Ser Thr 
    1325                 1330                 1335             


Gln Trp  Ser Lys Asn Met Lys  His Leu Thr Pro Ser  Thr Leu Thr 
    1340                 1345                 1350             


Gln Ile  Asp Tyr Asn Glu Lys  Glu Lys Gly Ala Ile  Thr Gln Ser 
    1355                 1360                 1365             


Pro Leu  Ser Asp Cys Leu Thr  Arg Ser His Ser Ile  Pro Gln Ala 
    1370                 1375                 1380             


Asn Arg  Ser Pro Leu Pro Ile  Ala Lys Val Ser Ser  Phe Pro Ser 
    1385                 1390                 1395             


Ile Arg  Pro Ile Tyr Leu Thr  Arg Val Leu Phe Gln  Asp Asn Ser 
    1400                 1405                 1410             


Ser His  Leu Pro Ala Ala Ser  Tyr Arg Lys Lys Asp  Ser Gly Val 
    1415                 1420                 1425             


Gln Glu  Ser Ser His Phe Leu  Gln Gly Ala Lys Lys  Asn Asn Leu 
    1430                 1435                 1440             


Ser Leu  Ala Ile Leu Thr Leu  Glu Met Thr Gly Asp  Gln Arg Glu 
    1445                 1450                 1455             


Val Gly  Ser Leu Gly Thr Ser  Ala Thr Asn Ser Val  Thr Tyr Lys 
    1460                 1465                 1470             


Lys Val  Glu Asn Thr Val Leu  Pro Lys Pro Asp Leu  Pro Lys Thr 
    1475                 1480                 1485             


Ser Gly  Lys Val Glu Leu Leu  Pro Lys Val His Ile  Tyr Gln Lys 
    1490                 1495                 1500             


Asp Leu  Phe Pro Thr Glu Thr  Ser Asn Gly Ser Pro  Gly His Leu 
    1505                 1510                 1515             


Asp Leu  Val Glu Gly Ser Leu  Leu Gln Gly Thr Glu  Gly Ala Ile 
    1520                 1525                 1530             


Lys Trp  Asn Glu Ala Asn Arg  Pro Gly Lys Val Pro  Phe Leu Arg 
    1535                 1540                 1545             


Val Ala  Thr Glu Ser Ser Ala  Lys Thr Pro Ser Lys  Leu Leu Asp 
    1550                 1555                 1560             


Pro Leu  Ala Trp Asp Asn His  Tyr Gly Thr Gln Ile  Pro Lys Glu 
    1565                 1570                 1575             


Glu Trp  Lys Ser Gln Glu Lys  Ser Pro Glu Lys Thr  Ala Phe Lys 
    1580                 1585                 1590             


Lys Lys  Asp Thr Ile Leu Ser  Leu Asn Ala Cys Glu  Ser Asn His 
    1595                 1600                 1605             


Ala Ile  Ala Ala Ile Asn Glu  Gly Gln Asn Lys Pro  Glu Ile Glu 
    1610                 1615                 1620             


Val Thr  Trp Ala Lys Gln Gly  Arg Thr Glu Arg Leu  Cys Ser Gln 
    1625                 1630                 1635             


Asn Pro  Pro Val Leu Lys Arg  His Gln Arg Glu Ile  Thr Arg Thr 
    1640                 1645                 1650             


Thr Leu  Gln Ser Asp Gln Glu  Glu Ile Asp Tyr Asp  Asp Thr Ile 
    1655                 1660                 1665             


Ser Val  Glu Met Lys Lys Glu  Asp Phe Asp Ile Tyr  Asp Glu Asp 
    1670                 1675                 1680             


Glu Asn  Gln Ser Pro Arg Ser  Phe Gln Lys Lys Thr  Arg His Tyr 
    1685                 1690                 1695             


Phe Ile  Ala Ala Val Glu Arg  Leu Trp Asp Tyr Gly  Met Ser Ser 
    1700                 1705                 1710             


Ser Pro  His Val Leu Arg Asn  Arg Ala Gln Ser Gly  Ser Val Pro 
    1715                 1720                 1725             


Gln Phe  Lys Lys Val Val Phe  Gln Glu Phe Thr Asp  Gly Ser Phe 
    1730                 1735                 1740             


Thr Gln  Pro Leu Tyr Arg Gly  Glu Leu Asn Glu His  Leu Gly Leu 
    1745                 1750                 1755             


Leu Gly  Pro Tyr Ile Arg Ala  Glu Val Glu Asp Asn  Ile Met Val 
    1760                 1765                 1770             


Thr Phe  Arg Asn Gln Ala Ser  Arg Pro Tyr Ser Phe  Tyr Ser Ser 
    1775                 1780                 1785             


Leu Ile  Ser Tyr Glu Glu Asp  Gln Arg Gln Gly Ala  Glu Pro Arg 
    1790                 1795                 1800             


Lys Asn  Phe Val Lys Pro Asn  Glu Thr Lys Thr Tyr  Phe Trp Lys 
    1805                 1810                 1815             


Val Gln  His His Met Ala Pro  Thr Lys Asp Glu Phe  Asp Cys Lys 
    1820                 1825                 1830             


Ala Trp  Ala Tyr Phe Ser Asp  Val Asp Leu Glu Lys  Asp Val His 
    1835                 1840                 1845             


Ser Gly  Leu Ile Gly Pro Leu  Leu Val Cys His Thr  Asn Thr Leu 
    1850                 1855                 1860             


Asn Pro  Ala His Gly Arg Gln  Val Thr Val Gln Glu  Phe Ala Leu 
    1865                 1870                 1875             


Phe Phe  Thr Ile Phe Asp Glu  Thr Lys Ser Trp Tyr  Phe Thr Glu 
    1880                 1885                 1890             


Asn Met  Glu Arg Asn Cys Arg  Ala Pro Cys Asn Ile  Gln Met Glu 
    1895                 1900                 1905             


Asp Pro  Thr Phe Lys Glu Asn  Tyr Arg Phe His Ala  Ile Asn Gly 
    1910                 1915                 1920             


Tyr Ile  Met Asp Thr Leu Pro  Gly Leu Val Met Ala  Gln Asp Gln 
    1925                 1930                 1935             


Arg Ile  Arg Trp Tyr Leu Leu  Ser Met Gly Ser Asn  Glu Asn Ile 
    1940                 1945                 1950             


His Ser  Ile His Phe Ser Gly  His Val Phe Thr Val  Arg Lys Lys 
    1955                 1960                 1965             


Glu Glu  Tyr Lys Met Ala Leu  Tyr Asn Leu Tyr Pro  Gly Val Phe 
    1970                 1975                 1980             


Glu Thr  Val Glu Met Leu Pro  Ser Lys Ala Gly Ile  Trp Arg Val 
    1985                 1990                 1995             


Glu Cys  Leu Ile Gly Glu His  Leu His Ala Gly Met  Ser Thr Leu 
    2000                 2005                 2010             


Phe Leu  Val Tyr Ser Asn Lys  Cys Gln Thr Pro Leu  Gly Met Ala 
    2015                 2020                 2025             


Ser Gly  His Ile Arg Asp Phe  Gln Ile Thr Ala Ser  Gly Gln Tyr 
    2030                 2035                 2040             


Gly Gln  Trp Ala Pro Lys Leu  Ala Arg Leu His Tyr  Ser Gly Ser 
    2045                 2050                 2055             


Ile Asn  Ala Trp Ser Thr Lys  Glu Pro Phe Ser Trp  Ile Lys Val 
    2060                 2065                 2070             


Asp Leu  Leu Ala Pro Met Ile  Ile His Gly Ile Lys  Thr Gln Gly 
    2075                 2080                 2085             


Ala Arg  Gln Lys Phe Ser Ser  Leu Tyr Ile Ser Gln  Phe Ile Ile 
    2090                 2095                 2100             


Met Tyr  Ser Leu Asp Gly Lys  Lys Trp Gln Thr Tyr  Arg Gly Asn 
    2105                 2110                 2115             


Ser Thr  Gly Thr Leu Met Val  Phe Phe Gly Asn Val  Asp Ser Ser 
    2120                 2125                 2130             


Gly Ile  Lys His Asn Ile Phe  Asn Pro Pro Ile Ile  Ala Arg Tyr 
    2135                 2140                 2145             


Ile Arg  Leu His Pro Thr His  Tyr Ser Ile Arg Ser  Thr Leu Arg 
    2150                 2155                 2160             


Met Glu  Leu Met Gly Cys Asp  Leu Asn Ser Cys Ser  Met Pro Leu 
    2165                 2170                 2175             


Gly Met  Glu Ser Lys Ala Ile  Ser Asp Ala Gln Ile  Thr Ala Ser 
    2180                 2185                 2190             


Ser Tyr  Phe Thr Asn Met Phe  Ala Thr Trp Ser Pro  Ser Lys Ala 
    2195                 2200                 2205             


Arg Leu  His Leu Gln Gly Arg  Ser Asn Ala Trp Arg  Pro Gln Val 
    2210                 2215                 2220             


Asn Asn  Pro Lys Glu Trp Leu  Gln Val Asp Phe Gln  Lys Thr Met 
    2225                 2230                 2235             


Lys Val  Thr Gly Val Thr Thr  Gln Gly Val Lys Ser  Leu Leu Thr 
    2240                 2245                 2250             


Ser Met  Tyr Val Lys Glu Phe  Leu Ile Ser Ser Ser  Gln Asp Gly 
    2255                 2260                 2265             


His Gln  Trp Thr Leu Phe Phe  Gln Asn Gly Lys Val  Lys Val Phe 
    2270                 2275                 2280             


Gln Gly  Asn Gln Asp Ser Phe  Thr Pro Val Val Asn  Ser Leu Asp 
    2285                 2290                 2295             


Pro Pro  Leu Leu Thr Arg Tyr  Leu Arg Ile His Pro  Gln Ser Trp 
    2300                 2305                 2310             


Val His  Gln Ile Ala Leu Arg  Met Glu Val Leu Gly  Cys Glu Ala 
    2315                 2320                 2325             


Gln Asp  Leu Tyr 
    2330         


<210>  9
<211>  288
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  9

Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro 
1               5                   10                  15      


Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 
            20                  25                  30          


Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 
        35                  40                  45              


Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 
    50                  55                  60                  


Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr 
65                  70                  75                  80  


Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 
                85                  90                  95      


Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu 
            100                 105                 110         


Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr 
        115                 120                 125             


Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 
    130                 135                 140                 


Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu 
145                 150                 155                 160 


Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro 
                165                 170                 175     


Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 
            180                 185                 190         


Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro 
        195                 200                 205             


Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr 
    210                 215                 220                 


Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 
225                 230                 235                 240 


Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro 
                245                 250                 255     


Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 
            260                 265                 270         


Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 
        275                 280                 285             


<210>  10
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  10

Thr Ser Thr Glu Glu Gly Ala Ser Ile Ser Asp Lys Asn Thr Gly Asp 
1               5                   10                  15      


Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys 
            20                  25                  30          


Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Asp Lys Thr His 
        35                  40                  45      


<210>  11
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  11

Thr Ser Thr Glu Glu Gly Ala Ser Ser Asp Lys Asn Thr Gly Asp Tyr 
1               5                   10                  15      


Tyr Glu Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn 
            20                  25                  30          


Asn Ala Ile Glu Pro Arg Ser Phe Ser Asp Lys Thr His 
        35                  40                  45  


<210>  12
<211>  1947
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  12

Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 
1               5                   10                  15      


Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 
            20                  25                  30          


Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 
        35                  40                  45              


Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro 
    50                  55                  60                  


Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val 
65                  70                  75                  80  


Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 
                85                  90                  95      


Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 
            100                 105                 110         


Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val 
        115                 120                 125             


Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn 
    130                 135                 140                 


Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser 
145                 150                 155                 160 


His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 
                165                 170                 175     


Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu 
            180                 185                 190         


His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp 
        195                 200                 205             


His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser 
    210                 215                 220                 


Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg 
225                 230                 235                 240 


Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His 
                245                 250                 255     


Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu 
            260                 265                 270         


Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 
        275                 280                 285             


Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly 
    290                 295                 300                 


Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met 
305                 310                 315                 320 


Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg 
                325                 330                 335     


Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp 
            340                 345                 350         


Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe 
        355                 360                 365             


Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His 
    370                 375                 380                 


Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu 
385                 390                 395                 400 


Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro 
                405                 410                 415     


Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr 
            420                 425                 430         


Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile 
        435                 440                 445             


Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile 
    450                 455                 460                 


Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile 
465                 470                 475                 480 


Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys 
                485                 490                 495     


His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys 
            500                 505                 510         


Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys 
        515                 520                 525             


Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala 
    530                 535                 540                 


Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp 
545                 550                 555                 560 


Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu Phe 
                565                 570                 575     


Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln 
            580                 585                 590         


Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp Pro Glu Phe 
        595                 600                 605             


Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser 
    610                 615                 620                 


Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu 
625                 630                 635                 640 


Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr 
                645                 650                 655     


Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro 
            660                 665                 670         


Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp 
        675                 680                 685             


Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala 
    690                 695                 700                 


Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu 
705                 710                 715                 720 


Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala 
                725                 730                 735     


Ile Glu Pro Arg Ser Phe Ser Gln Asn Gly Thr Ser Glu Ser Ala Thr 
            740                 745                 750         


Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 
        755                 760                 765             


Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu 
    770                 775                 780                 


Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr 
785                 790                 795                 800 


Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 
                805                 810                 815     


Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser 
            820                 825                 830         


Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser 
        835                 840                 845             


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 
    850                 855                 860                 


Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro 
865                 870                 875                 880 


Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser 
                885                 890                 895     


Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 
            900                 905                 910         


Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser 
        915                 920                 925             


Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser 
    930                 935                 940                 


Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 
945                 950                 955                 960 


Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser 
                965                 970                 975     


Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser 
            980                 985                 990         


Glu Gly Ser Ala Pro Gly Ser Glu  Pro Ala Thr Ser Gly  Ser Glu Thr 
        995                 1000                 1005             


Pro Gly  Thr Ser Glu Ser Ala  Thr Pro Glu Ser Gly  Pro Gly Thr 
    1010                 1015                 1020             


Ser Thr  Glu Pro Ser Glu Gly  Ser Ala Pro Ala Ser  Ser Glu Ile 
    1025                 1030                 1035             


Thr Arg  Thr Thr Leu Gln Ser  Asp Gln Glu Glu Ile  Asp Tyr Asp 
    1040                 1045                 1050             


Asp Thr  Ile Ser Val Glu Met  Lys Lys Glu Asp Phe  Asp Ile Tyr 
    1055                 1060                 1065             


Asp Glu  Asp Glu Asn Gln Ser  Pro Arg Ser Phe Gln  Lys Lys Thr 
    1070                 1075                 1080             


Arg His  Tyr Phe Ile Ala Ala  Val Glu Arg Leu Trp  Asp Tyr Gly 
    1085                 1090                 1095             


Met Ser  Ser Ser Pro His Val  Leu Arg Asn Arg Ala  Gln Ser Gly 
    1100                 1105                 1110             


Ser Val  Pro Gln Phe Lys Lys  Val Val Phe Gln Glu  Phe Thr Asp 
    1115                 1120                 1125             


Gly Ser  Phe Thr Gln Pro Leu  Tyr Arg Gly Glu Leu  Asn Glu His 
    1130                 1135                 1140             


Leu Gly  Leu Leu Gly Pro Tyr  Ile Arg Ala Glu Val  Glu Asp Asn 
    1145                 1150                 1155             


Ile Met  Val Thr Phe Arg Asn  Gln Ala Ser Arg Pro  Tyr Ser Phe 
    1160                 1165                 1170             


Tyr Ser  Ser Leu Ile Ser Tyr  Glu Glu Asp Gln Arg  Gln Gly Ala 
    1175                 1180                 1185             


Glu Pro  Arg Lys Asn Phe Val  Lys Pro Asn Glu Thr  Lys Thr Tyr 
    1190                 1195                 1200             


Phe Trp  Lys Val Gln His His  Met Ala Pro Thr Lys  Asp Glu Phe 
    1205                 1210                 1215             


Asp Cys  Lys Ala Trp Ala Tyr  Phe Ser Asp Val Asp  Leu Glu Lys 
    1220                 1225                 1230             


Asp Val  His Ser Gly Leu Ile  Gly Pro Leu Leu Val  Cys His Thr 
    1235                 1240                 1245             


Asn Thr  Leu Asn Pro Ala His  Gly Arg Gln Val Thr  Val Gln Glu 
    1250                 1255                 1260             


Phe Ala  Leu Phe Phe Thr Ile  Phe Asp Glu Thr Lys  Ser Trp Tyr 
    1265                 1270                 1275             


Phe Thr  Glu Asn Met Glu Arg  Asn Cys Arg Ala Pro  Cys Asn Ile 
    1280                 1285                 1290             


Gln Met  Glu Asp Pro Thr Phe  Lys Glu Asn Tyr Arg  Phe His Ala 
    1295                 1300                 1305             


Ile Asn  Gly Tyr Ile Met Asp  Thr Leu Pro Gly Leu  Val Met Ala 
    1310                 1315                 1320             


Gln Asp  Gln Arg Ile Arg Trp  Tyr Leu Leu Ser Met  Gly Ser Asn 
    1325                 1330                 1335             


Glu Asn  Ile His Ser Ile His  Phe Ser Gly His Val  Phe Thr Val 
    1340                 1345                 1350             


Arg Lys  Lys Glu Glu Tyr Lys  Met Ala Leu Tyr Asn  Leu Tyr Pro 
    1355                 1360                 1365             


Gly Val  Phe Glu Thr Val Glu  Met Leu Pro Ser Lys  Ala Gly Ile 
    1370                 1375                 1380             


Trp Arg  Val Glu Cys Leu Ile  Gly Glu His Leu His  Ala Gly Met 
    1385                 1390                 1395             


Ser Thr  Leu Phe Leu Val Tyr  Ser Asn Lys Cys Gln  Thr Pro Leu 
    1400                 1405                 1410             


Gly Met  Ala Ser Gly His Ile  Arg Asp Phe Gln Ile  Thr Ala Ser 
    1415                 1420                 1425             


Gly Gln  Tyr Gly Gln Trp Ala  Pro Lys Leu Ala Arg  Leu His Tyr 
    1430                 1435                 1440             


Ser Gly  Ser Ile Asn Ala Trp  Ser Thr Lys Glu Pro  Phe Ser Trp 
    1445                 1450                 1455             


Ile Lys  Val Asp Leu Leu Ala  Pro Met Ile Ile His  Gly Ile Lys 
    1460                 1465                 1470             


Thr Gln  Gly Ala Arg Gln Lys  Phe Ser Ser Leu Tyr  Ile Ser Gln 
    1475                 1480                 1485             


Phe Ile  Ile Met Tyr Ser Leu  Asp Gly Lys Lys Trp  Gln Thr Tyr 
    1490                 1495                 1500             


Arg Gly  Asn Ser Thr Gly Thr  Leu Met Val Phe Phe  Gly Asn Val 
    1505                 1510                 1515             


Asp Ser  Ser Gly Ile Lys His  Asn Ile Phe Asn Pro  Pro Ile Ile 
    1520                 1525                 1530             


Ala Arg  Tyr Ile Arg Leu His  Pro Thr His Tyr Ser  Ile Arg Ser 
    1535                 1540                 1545             


Thr Leu  Arg Met Glu Leu Met  Gly Cys Asp Leu Asn  Ser Cys Ser 
    1550                 1555                 1560             


Met Pro  Leu Gly Met Glu Ser  Lys Ala Ile Ser Asp  Ala Gln Ile 
    1565                 1570                 1575             


Thr Ala  Ser Ser Tyr Phe Thr  Asn Met Phe Ala Thr  Trp Ser Pro 
    1580                 1585                 1590             


Ser Lys  Ala Arg Leu His Leu  Gln Gly Arg Ser Asn  Ala Trp Arg 
    1595                 1600                 1605             


Pro Gln  Val Asn Asn Pro Lys  Glu Trp Leu Gln Val  Asp Phe Gln 
    1610                 1615                 1620             


Lys Thr  Met Lys Val Thr Gly  Val Thr Thr Gln Gly  Val Lys Ser 
    1625                 1630                 1635             


Leu Leu  Thr Ser Met Tyr Val  Lys Glu Phe Leu Ile  Ser Ser Ser 
    1640                 1645                 1650             


Gln Asp  Gly His Gln Trp Thr  Leu Phe Phe Gln Asn  Gly Lys Val 
    1655                 1660                 1665             


Lys Val  Phe Gln Gly Asn Gln  Asp Ser Phe Thr Pro  Val Val Asn 
    1670                 1675                 1680             


Ser Leu  Asp Pro Pro Leu Leu  Thr Arg Tyr Leu Arg  Ile His Pro 
    1685                 1690                 1695             


Gln Ser  Trp Val His Gln Ile  Ala Leu Arg Met Glu  Val Leu Gly 
    1700                 1705                 1710             


Cys Glu  Ala Gln Asp Leu Tyr  Asp Lys Thr His Thr  Cys Pro Pro 
    1715                 1720                 1725             


Cys Pro  Ala Pro Glu Leu Leu  Gly Gly Pro Ser Val  Phe Leu Phe 
    1730                 1735                 1740             


Pro Pro  Lys Pro Lys Asp Thr  Leu Met Ile Ser Arg  Thr Pro Glu 
    1745                 1750                 1755             


Val Thr  Cys Val Val Val Asp  Val Ser His Glu Asp  Pro Glu Val 
    1760                 1765                 1770             


Lys Phe  Asn Trp Tyr Val Asp  Gly Val Glu Val His  Asn Ala Lys 
    1775                 1780                 1785             


Thr Lys  Pro Arg Glu Glu Gln  Tyr Asn Ser Thr Tyr  Arg Val Val 
    1790                 1795                 1800             


Ser Val  Leu Thr Val Leu His  Gln Asp Trp Leu Asn  Gly Lys Glu 
    1805                 1810                 1815             


Tyr Lys  Cys Lys Val Ser Asn  Lys Ala Leu Pro Ala  Pro Ile Glu 
    1820                 1825                 1830             


Lys Thr  Ile Ser Lys Ala Lys  Gly Gln Pro Arg Glu  Pro Gln Val 
    1835                 1840                 1845             


Tyr Thr  Leu Pro Pro Ser Arg  Asp Glu Leu Thr Lys  Asn Gln Val 
    1850                 1855                 1860             


Ser Leu  Thr Cys Leu Val Lys  Gly Phe Tyr Pro Ser  Asp Ile Ala 
    1865                 1870                 1875             


Val Glu  Trp Glu Ser Asn Gly  Gln Pro Glu Asn Asn  Tyr Lys Thr 
    1880                 1885                 1890             


Thr Pro  Pro Val Leu Asp Ser  Asp Gly Ser Phe Phe  Leu Tyr Ser 
    1895                 1900                 1905             


Lys Leu  Thr Val Asp Lys Ser  Arg Trp Gln Gln Gly  Asn Val Phe 
    1910                 1915                 1920             


Ser Cys  Ser Val Met His Glu  Ala Leu His Asn His  Tyr Thr Gln 
    1925                 1930                 1935             


Lys Ser  Leu Ser Leu Ser Pro  Gly Lys 
    1940                 1945         


<210>  13
<211>  288
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  13

Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu 
1               5                   10                  15      


Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly 
            20                  25                  30          


Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 
        35                  40                  45              


Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 
    50                  55                  60                  


Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu 
65                  70                  75                  80  


Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 
                85                  90                  95      


Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 
            100                 105                 110         


Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr 
        115                 120                 125             


Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 
    130                 135                 140                 


Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro 
145                 150                 155                 160 


Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 
                165                 170                 175     


Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 
            180                 185                 190         


Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 
        195                 200                 205             


Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 
    210                 215                 220                 


Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 
225                 230                 235                 240 


Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala 
                245                 250                 255     


Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro 
            260                 265                 270         


Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 
        275                 280                 285             


<210>  14
<211>  144
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  14

Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala 
1               5                   10                  15      


Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
            20                  25                  30          


Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 
        35                  40                  45              


Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu 
    50                  55                  60                  


Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser 
65                  70                  75                  80  


Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 
                85                  90                  95      


Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
            100                 105                 110         


Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser 
        115                 120                 125             


Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly 
    130                 135                 140                 


<210>  15
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  15

Asp Lys Asn Thr Gly Asp Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser 
1               5                   10                  15      


Ala Tyr Leu Leu Ser Lys Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser 
            20                  25                  30          


<210>  16
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe 
1               5                   10                  15      


Cys Phe Ser 
            


<210>  17
<211>  745
<212>  PRT
<213>  Homo sapiens

<400>  17

Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 
1               5                   10                  15      


Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 
            20                  25                  30          


Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 
        35                  40                  45              


Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro 
    50                  55                  60                  


Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val 
65                  70                  75                  80  


Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 
                85                  90                  95      


Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 
            100                 105                 110         


Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val 
        115                 120                 125             


Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn 
    130                 135                 140                 


Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser 
145                 150                 155                 160 


His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 
                165                 170                 175     


Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu 
            180                 185                 190         


His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp 
        195                 200                 205             


His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser 
    210                 215                 220                 


Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg 
225                 230                 235                 240 


Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His 
                245                 250                 255     


Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu 
            260                 265                 270         


Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 
        275                 280                 285             


Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly 
    290                 295                 300                 


Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met 
305                 310                 315                 320 


Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg 
                325                 330                 335     


Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp 
            340                 345                 350         


Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe 
        355                 360                 365             


Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His 
    370                 375                 380                 


Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu 
385                 390                 395                 400 


Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro 
                405                 410                 415     


Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr 
            420                 425                 430         


Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile 
        435                 440                 445             


Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile 
    450                 455                 460                 


Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile 
465                 470                 475                 480 


Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys 
                485                 490                 495     


His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys 
            500                 505                 510         


Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys 
        515                 520                 525             


Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala 
    530                 535                 540                 


Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp 
545                 550                 555                 560 


Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu Phe 
                565                 570                 575     


Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln 
            580                 585                 590         


Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp Pro Glu Phe 
        595                 600                 605             


Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser 
    610                 615                 620                 


Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu 
625                 630                 635                 640 


Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr 
                645                 650                 655     


Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro 
            660                 665                 670         


Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp 
        675                 680                 685             


Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala 
    690                 695                 700                 


Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu 
705                 710                 715                 720 


Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala 
                725                 730                 735     


Ile Glu Pro Arg Ser Phe Ser Gln Asn 
            740                 745 


<210>  18
<211>  684
<212>  PRT
<213>  Homo sapiens

<400>  18

Glu Ile Thr Arg Thr Thr Leu Gln Ser Asp Gln Glu Glu Ile Asp Tyr 
1               5                   10                  15      


Asp Asp Thr Ile Ser Val Glu Met Lys Lys Glu Asp Phe Asp Ile Tyr 
            20                  25                  30          


Asp Glu Asp Glu Asn Gln Ser Pro Arg Ser Phe Gln Lys Lys Thr Arg 
        35                  40                  45              


His Tyr Phe Ile Ala Ala Val Glu Arg Leu Trp Asp Tyr Gly Met Ser 
    50                  55                  60                  


Ser Ser Pro His Val Leu Arg Asn Arg Ala Gln Ser Gly Ser Val Pro 
65                  70                  75                  80  


Gln Phe Lys Lys Val Val Phe Gln Glu Phe Thr Asp Gly Ser Phe Thr 
                85                  90                  95      


Gln Pro Leu Tyr Arg Gly Glu Leu Asn Glu His Leu Gly Leu Leu Gly 
            100                 105                 110         


Pro Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile Met Val Thr Phe Arg 
        115                 120                 125             


Asn Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser Ser Leu Ile Ser Tyr 
    130                 135                 140                 


Glu Glu Asp Gln Arg Gln Gly Ala Glu Pro Arg Lys Asn Phe Val Lys 
145                 150                 155                 160 


Pro Asn Glu Thr Lys Thr Tyr Phe Trp Lys Val Gln His His Met Ala 
                165                 170                 175     


Pro Thr Lys Asp Glu Phe Asp Cys Lys Ala Trp Ala Tyr Phe Ser Asp 
            180                 185                 190         


Val Asp Leu Glu Lys Asp Val His Ser Gly Leu Ile Gly Pro Leu Leu 
        195                 200                 205             


Val Cys His Thr Asn Thr Leu Asn Pro Ala His Gly Arg Gln Val Thr 
    210                 215                 220                 


Val Gln Glu Phe Ala Leu Phe Phe Thr Ile Phe Asp Glu Thr Lys Ser 
225                 230                 235                 240 


Trp Tyr Phe Thr Glu Asn Met Glu Arg Asn Cys Arg Ala Pro Cys Asn 
                245                 250                 255     


Ile Gln Met Glu Asp Pro Thr Phe Lys Glu Asn Tyr Arg Phe His Ala 
            260                 265                 270         


Ile Asn Gly Tyr Ile Met Asp Thr Leu Pro Gly Leu Val Met Ala Gln 
        275                 280                 285             


Asp Gln Arg Ile Arg Trp Tyr Leu Leu Ser Met Gly Ser Asn Glu Asn 
    290                 295                 300                 


Ile His Ser Ile His Phe Ser Gly His Val Phe Thr Val Arg Lys Lys 
305                 310                 315                 320 


Glu Glu Tyr Lys Met Ala Leu Tyr Asn Leu Tyr Pro Gly Val Phe Glu 
                325                 330                 335     


Thr Val Glu Met Leu Pro Ser Lys Ala Gly Ile Trp Arg Val Glu Cys 
            340                 345                 350         


Leu Ile Gly Glu His Leu His Ala Gly Met Ser Thr Leu Phe Leu Val 
        355                 360                 365             


Tyr Ser Asn Lys Cys Gln Thr Pro Leu Gly Met Ala Ser Gly His Ile 
    370                 375                 380                 


Arg Asp Phe Gln Ile Thr Ala Ser Gly Gln Tyr Gly Gln Trp Ala Pro 
385                 390                 395                 400 


Lys Leu Ala Arg Leu His Tyr Ser Gly Ser Ile Asn Ala Trp Ser Thr 
                405                 410                 415     


Lys Glu Pro Phe Ser Trp Ile Lys Val Asp Leu Leu Ala Pro Met Ile 
            420                 425                 430         


Ile His Gly Ile Lys Thr Gln Gly Ala Arg Gln Lys Phe Ser Ser Leu 
        435                 440                 445             


Tyr Ile Ser Gln Phe Ile Ile Met Tyr Ser Leu Asp Gly Lys Lys Trp 
    450                 455                 460                 


Gln Thr Tyr Arg Gly Asn Ser Thr Gly Thr Leu Met Val Phe Phe Gly 
465                 470                 475                 480 


Asn Val Asp Ser Ser Gly Ile Lys His Asn Ile Phe Asn Pro Pro Ile 
                485                 490                 495     


Ile Ala Arg Tyr Ile Arg Leu His Pro Thr His Tyr Ser Ile Arg Ser 
            500                 505                 510         


Thr Leu Arg Met Glu Leu Met Gly Cys Asp Leu Asn Ser Cys Ser Met 
        515                 520                 525             


Pro Leu Gly Met Glu Ser Lys Ala Ile Ser Asp Ala Gln Ile Thr Ala 
    530                 535                 540                 


Ser Ser Tyr Phe Thr Asn Met Phe Ala Thr Trp Ser Pro Ser Lys Ala 
545                 550                 555                 560 


Arg Leu His Leu Gln Gly Arg Ser Asn Ala Trp Arg Pro Gln Val Asn 
                565                 570                 575     


Asn Pro Lys Glu Trp Leu Gln Val Asp Phe Gln Lys Thr Met Lys Val 
            580                 585                 590         


Thr Gly Val Thr Thr Gln Gly Val Lys Ser Leu Leu Thr Ser Met Tyr 
        595                 600                 605             


Val Lys Glu Phe Leu Ile Ser Ser Ser Gln Asp Gly His Gln Trp Thr 
    610                 615                 620                 


Leu Phe Phe Gln Asn Gly Lys Val Lys Val Phe Gln Gly Asn Gln Asp 
625                 630                 635                 640 


Ser Phe Thr Pro Val Val Asn Ser Leu Asp Pro Pro Leu Leu Thr Arg 
                645                 650                 655     


Tyr Leu Arg Ile His Pro Gln Ser Trp Val His Gln Ile Ala Leu Arg 
            660                 665                 670         


Met Glu Val Leu Gly Cys Glu Ala Gln Asp Leu Tyr 
        675                 680                 


<210>  19
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Ile Pro Ala Arg Phe Ala Gly Val Leu Leu Ala Leu Ala Leu Ile 
1               5                   10                  15      


Leu Pro Gly Thr Leu Cys 
            20          


<210>  20
<211>  741
<212>  PRT
<213>  Homo sapiens

<400>  20

Ala Glu Gly Thr Arg Gly Arg Ser Ser Thr Ala Arg Cys Ser Leu Phe 
1               5                   10                  15      


Gly Ser Asp Phe Val Asn Thr Phe Asp Gly Ser Met Tyr Ser Phe Ala 
            20                  25                  30          


Gly Tyr Cys Ser Tyr Leu Leu Ala Gly Gly Cys Gln Lys Arg Ser Phe 
        35                  40                  45              


Ser Ile Ile Gly Asp Phe Gln Asn Gly Lys Arg Val Ser Leu Ser Val 
    50                  55                  60                  


Tyr Leu Gly Glu Phe Phe Asp Ile His Leu Phe Val Asn Gly Thr Val 
65                  70                  75                  80  


Thr Gln Gly Asp Gln Arg Val Ser Met Pro Tyr Ala Ser Lys Gly Leu 
                85                  90                  95      


Tyr Leu Glu Thr Glu Ala Gly Tyr Tyr Lys Leu Ser Gly Glu Ala Tyr 
            100                 105                 110         


Gly Phe Val Ala Arg Ile Asp Gly Ser Gly Asn Phe Gln Val Leu Leu 
        115                 120                 125             


Ser Asp Arg Tyr Phe Asn Lys Thr Cys Gly Leu Cys Gly Asn Phe Asn 
    130                 135                 140                 


Ile Phe Ala Glu Asp Asp Phe Met Thr Gln Glu Gly Thr Leu Thr Ser 
145                 150                 155                 160 


Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala Leu Ser Ser Gly Glu Gln 
                165                 170                 175     


Trp Cys Glu Arg Ala Ser Pro Pro Ser Ser Ser Cys Asn Ile Ser Ser 
            180                 185                 190         


Gly Glu Met Gln Lys Gly Leu Trp Glu Gln Cys Gln Leu Leu Lys Ser 
        195                 200                 205             


Thr Ser Val Phe Ala Arg Cys His Pro Leu Val Asp Pro Glu Pro Phe 
    210                 215                 220                 


Val Ala Leu Cys Glu Lys Thr Leu Cys Glu Cys Ala Gly Gly Leu Glu 
225                 230                 235                 240 


Cys Ala Cys Pro Ala Leu Leu Glu Tyr Ala Arg Thr Cys Ala Gln Glu 
                245                 250                 255     


Gly Met Val Leu Tyr Gly Trp Thr Asp His Ser Ala Cys Ser Pro Val 
            260                 265                 270         


Cys Pro Ala Gly Met Glu Tyr Arg Gln Cys Val Ser Pro Cys Ala Arg 
        275                 280                 285             


Thr Cys Gln Ser Leu His Ile Asn Glu Met Cys Gln Glu Arg Cys Val 
    290                 295                 300                 


Asp Gly Cys Ser Cys Pro Glu Gly Gln Leu Leu Asp Glu Gly Leu Cys 
305                 310                 315                 320 


Val Glu Ser Thr Glu Cys Pro Cys Val His Ser Gly Lys Arg Tyr Pro 
                325                 330                 335     


Pro Gly Thr Ser Leu Ser Arg Asp Cys Asn Thr Cys Ile Cys Arg Asn 
            340                 345                 350         


Ser Gln Trp Ile Cys Ser Asn Glu Glu Cys Pro Gly Glu Cys Leu Val 
        355                 360                 365             


Thr Gly Gln Ser His Phe Lys Ser Phe Asp Asn Arg Tyr Phe Thr Phe 
    370                 375                 380                 


Ser Gly Ile Cys Gln Tyr Leu Leu Ala Arg Asp Cys Gln Asp His Ser 
385                 390                 395                 400 


Phe Ser Ile Val Ile Glu Thr Val Gln Cys Ala Asp Asp Arg Asp Ala 
                405                 410                 415     


Val Cys Thr Arg Ser Val Thr Val Arg Leu Pro Gly Leu His Asn Ser 
            420                 425                 430         


Leu Val Lys Leu Lys His Gly Ala Gly Val Ala Met Asp Gly Gln Asp 
        435                 440                 445             


Ile Gln Leu Pro Leu Leu Lys Gly Asp Leu Arg Ile Gln His Thr Val 
    450                 455                 460                 


Thr Ala Ser Val Arg Leu Ser Tyr Gly Glu Asp Leu Gln Met Asp Trp 
465                 470                 475                 480 


Asp Gly Arg Gly Arg Leu Leu Val Lys Leu Ser Pro Val Tyr Ala Gly 
                485                 490                 495     


Lys Thr Cys Gly Leu Cys Gly Asn Tyr Asn Gly Asn Gln Gly Asp Asp 
            500                 505                 510         


Phe Leu Thr Pro Ser Gly Leu Ala Glu Pro Arg Val Glu Asp Phe Gly 
        515                 520                 525             


Asn Ala Trp Lys Leu His Gly Asp Cys Gln Asp Leu Gln Lys Gln His 
    530                 535                 540                 


Ser Asp Pro Cys Ala Leu Asn Pro Arg Met Thr Arg Phe Ser Glu Glu 
545                 550                 555                 560 


Ala Cys Ala Val Leu Thr Ser Pro Thr Phe Glu Ala Cys His Arg Ala 
                565                 570                 575     


Val Ser Pro Leu Pro Tyr Leu Arg Asn Cys Arg Tyr Asp Val Cys Ser 
            580                 585                 590         


Cys Ser Asp Gly Arg Glu Cys Leu Cys Gly Ala Leu Ala Ser Tyr Ala 
        595                 600                 605             


Ala Ala Cys Ala Gly Arg Gly Val Arg Val Ala Trp Arg Glu Pro Gly 
    610                 615                 620                 


Arg Cys Glu Leu Asn Cys Pro Lys Gly Gln Val Tyr Leu Gln Cys Gly 
625                 630                 635                 640 


Thr Pro Cys Asn Leu Thr Cys Arg Ser Leu Ser Tyr Pro Asp Glu Glu 
                645                 650                 655     


Cys Asn Glu Ala Cys Leu Glu Gly Cys Phe Cys Pro Pro Gly Leu Tyr 
            660                 665                 670         


Met Asp Glu Arg Gly Asp Cys Val Pro Lys Ala Gln Cys Pro Cys Tyr 
        675                 680                 685             


Tyr Asp Gly Glu Ile Phe Gln Pro Glu Asp Ile Phe Ser Asp His His 
    690                 695                 700                 


Thr Met Cys Tyr Cys Glu Asp Gly Phe Met His Cys Thr Met Ser Gly 
705                 710                 715                 720 


Val Pro Gly Ser Leu Leu Pro Asp Ala Val Leu Ser Ser Pro Leu Ser 
                725                 730                 735     


His Arg Ser Lys Arg 
            740     


<210>  21
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  21

Ser Leu Ser Cys Arg Pro Pro Met Val Lys Leu Val Cys Pro Ala Asp 
1               5                   10                  15      


Asn Leu Arg Ala Glu Gly Leu Glu Cys Thr Lys Thr Cys Gln Asn Tyr 
            20                  25                  30          


Asp Leu Glu Cys Met Ser Met Gly Cys Val Ser Gly Cys Leu Cys Pro 
        35                  40                  45              


Pro Gly Met Val Arg His Glu Asn Arg Cys Val Ala Leu Glu Arg Cys 
    50                  55                  60                  


Pro Cys Phe His Gln Gly Lys Glu Tyr Ala Pro Gly Glu Thr Val Lys 
65                  70                  75                  80  


Ile Gly Cys Asn Thr Cys Val Cys Arg Asp Arg Lys Trp Asn Cys Thr 
                85                  90                  95      


Asp His Val Cys Asp Ala Thr 
            100             


<210>  22
<211>  374
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  22

Cys Ser Thr Ile Gly Met Ala His Tyr Leu Thr Phe Asp Gly Leu Lys 
1               5                   10                  15      


Tyr Leu Phe Pro Gly Glu Cys Gln Tyr Val Leu Val Gln Asp Tyr Cys 
            20                  25                  30          


Gly Ser Asn Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Lys Gly Cys 
        35                  40                  45              


Ser His Pro Ser Val Lys Cys Lys Lys Arg Val Thr Ile Leu Val Glu 
    50                  55                  60                  


Gly Gly Glu Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys Arg Pro 
65                  70                  75                  80  


Met Lys Asp Glu Thr His Phe Glu Val Val Glu Ser Gly Arg Tyr Ile 
                85                  90                  95      


Ile Leu Leu Leu Gly Lys Ala Leu Ser Val Val Trp Asp Arg His Leu 
            100                 105                 110         


Ser Ile Ser Val Val Leu Lys Gln Thr Tyr Gln Glu Lys Val Cys Gly 
        115                 120                 125             


Leu Cys Gly Asn Phe Asp Gly Ile Gln Asn Asn Asp Leu Thr Ser Ser 
    130                 135                 140                 


Asn Leu Gln Val Glu Glu Asp Pro Val Asp Phe Gly Asn Ser Trp Lys 
145                 150                 155                 160 


Val Ser Ser Gln Cys Ala Asp Thr Arg Lys Val Pro Leu Asp Ser Ser 
                165                 170                 175     


Pro Ala Thr Cys His Asn Asn Ile Met Lys Gln Thr Met Val Asp Ser 
            180                 185                 190         


Ser Cys Arg Ile Leu Thr Ser Asp Val Phe Gln Asp Cys Asn Lys Leu 
        195                 200                 205             


Val Asp Pro Glu Pro Tyr Leu Asp Val Cys Ile Tyr Asp Thr Cys Ser 
    210                 215                 220                 


Cys Glu Ser Ile Gly Asp Cys Ala Ala Phe Cys Asp Thr Ile Ala Ala 
225                 230                 235                 240 


Tyr Ala His Val Cys Ala Gln His Gly Lys Val Val Thr Trp Arg Thr 
                245                 250                 255     


Ala Thr Leu Cys Pro Gln Ser Cys Glu Glu Arg Asn Leu Arg Glu Asn 
            260                 265                 270         


Gly Tyr Glu Ala Glu Trp Arg Tyr Asn Ser Cys Ala Pro Ala Cys Gln 
        275                 280                 285             


Val Thr Cys Gln His Pro Glu Pro Leu Ala Cys Pro Val Gln Cys Val 
    290                 295                 300                 


Glu Gly Cys His Ala His Cys Pro Pro Gly Lys Ile Leu Asp Glu Leu 
305                 310                 315                 320 


Leu Gln Thr Cys Val Asp Pro Glu Asp Cys Pro Val Cys Glu Val Ala 
                325                 330                 335     


Gly Arg Arg Phe Ala Ser Gly Lys Lys Val Thr Leu Asn Pro Ser Asp 
            340                 345                 350         


Pro Glu His Cys Gln Ile Cys His Cys Asp Val Val Asn Leu Thr Cys 
        355                 360                 365             


Glu Ala Cys Gln Glu Pro 
    370                 


<210>  23
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  23

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly 
225     


<210>  24
<211>  291
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  24

Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro 
1               5                   10                  15      


Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 
            20                  25                  30          


Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 
        35                  40                  45              


Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 
    50                  55                  60                  


Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr 
65                  70                  75                  80  


Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 
                85                  90                  95      


Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu 
            100                 105                 110         


Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr 
        115                 120                 125             


Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 
    130                 135                 140                 


Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu 
145                 150                 155                 160 


Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro 
                165                 170                 175     


Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 
            180                 185                 190         


Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro 
        195                 200                 205             


Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr 
    210                 215                 220                 


Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 
225                 230                 235                 240 


Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro 
                245                 250                 255     


Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 
            260                 265                 270         


Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 
        275                 280                 285             


Ala Ser Ser 
    290     


