                         SEQUENCE LISTING

<110>  The Trustees of Columbia University in the City of New York
 
<120>  Novel mRNA vaccine for autoimmunity

<130>  15003-472PC0

<150>  63/202,741
<151>  2021-06-22

<160>  62    

<170>  PatentIn version 3.5

<210>  1
<211>  2253
<212>  DNA
<213>  Homo sapiens

<400>  1
atgtctcagt ggtacgaact tcagcagctt gactcaaaat tcctggagca ggttcaccag       60

ctttatgatg acagttttcc catggaaatc agacagtacc tggcacagtg gttagaaaag      120

caagactggg agcacgctgc caatgatgtt tcatttgcca ccatccgttt tcatgacctc      180

ctgtcacagc tggatgatca atatagtcgc ttttctttgg agaataactt cttgctacag      240

cataacataa ggaaaagcaa gcgtaatctt caggataatt ttcaggaaga cccaatccag      300

atgtctatga tcatttacag ctgtctgaag gaagaaagga aaattctgga aaacgcccag      360

agatttaatc aggctcagtc ggggaatatt cagagcacag tgatgttaga caaacagaaa      420

gagcttgaca gtaaagtcag aaatgtgaag gacaaggtta tgtgtataga gcatgaaatc      480

aagagcctgg aagatttaca agatgaatat gacttcaaat gcaaaacctt gcagaacaga      540

gaacacgaga ccaatggtgt ggcaaagagt gatcagaaac aagaacagct gttactcaag      600

aagatgtatt taatgcttga caataagaga aaggaagtag ttcacaaaat aatagagttg      660

ctgaatgtca ctgaacttac ccagaatgcc ctgattaatg atgaactagt ggagtggaag      720

cggagacagc agagcgcctg tattgggggg ccgcccaatg cttgcttgga tcagctgcag      780

aactggttca ctatagttgc ggagagtctg cagcaagttc ggcagcagct taaaaagttg      840

gaggaattgg aacagaaata cacctacgaa catgacccta tcacaaaaaa caaacaagtg      900

ttatgggacc gcaccttcag tcttttccag cagctcattc agagctcgtt tgtggtggaa      960

agacagccct gcatgccaac gcaccctcag aggccgctgg tcttgaagac aggggtccag     1020

ttcactgtga agttgagact gttggtgaaa ttgcaagagc tgaattataa tttgaaagtc     1080

aaagtcttat ttgataaaga tgtgaatgag agaaatacag taaaaggatt taggaagttc     1140

aacattttgg gcacgcacac aaaagtgatg aacatggagg agtccaccaa tggcagtctg     1200

gcggctgaat ttcggcacct gcaattgaaa gaacagaaaa atgctggcac cagaacgaat     1260

gagggtcctc tcatcgttac tgaagagctt cactccctta gttttgaaac ccaattgtgc     1320

cagcctggtt tggtaattga cctcgagacg acctctctgc ccgttgtggt gatctccaac     1380

gtcagccagc tcccgagcgg ttgggcctcc atcctttggt acaacatgct ggtggcggaa     1440

cccaggaatc tgtccttctt cctgactcca ccatgtgcac gatgggctca gctttcagaa     1500

gtgctgagtt ggcagttttc ttctgtcacc aaaagaggtc tcaatgtgga ccagctgaac     1560

atgttgggag agaagcttct tggtcctaac gccagccccg atggtctcat tccgtggacg     1620

aggttttgta aggaaaatat aaatgataaa aattttccct tctggctttg gattgaaagc     1680

atcctagaac tcattaaaaa acacctgctc cctctctgga atgatgggtg catcatgggc     1740

ttcatcagca aggagcgaga gcgtgccctg ttgaaggacc agcagccggg gaccttcctg     1800

ctgcggttca gtgagagctc ccgggaaggg gccatcacat tcacatgggt ggagcggtcc     1860

cagaacggag gcgaacctga cttccatgcg gttgaaccct acacgaagaa agaactttct     1920

gctgttactt tccctgacat cattcgcaat tacaaagtca tggcttgtga gtgtattcct     1980

gagaatcccc tgaagtatct gtatccaaat attgacaaag accatgcctt tggaaagtat     2040

tactccaggc caaaggaagc accagagcca atggaacttg atggccctaa aggaactgga     2100

tatatcaaga ctgagttgat ttctgtgtct gaagttcacc cttctagact tcagaccaca     2160

gacaacctgc tccccatgtc tcctgaggag tttgacgagg tgtctcggat agtgggctct     2220

gtagaattcg acagtatgat gaacacagta tag                                  2253


<210>  2
<211>  2268
<212>  DNA
<213>  Mus musculus

<400>  2
atgtcacagt ggttcgagct tcagcagctg gactccaagt tcctggagca ggtccaccag       60

ctgtacgatg acagtttccc catggaaatc agacagtacc tggcccagtg gctggaaaag      120

caagactggg agcacgctgc ctatgatgtc tcgtttgcga ccatccgctt ccatgacctc      180

ctctcacagc tggacgacca gtacagccgc ttttctctgg agaataattt cttgttgcag      240

cacaacatac ggaaaagcaa gcgtaatctc caggataact tccaagaaga tcccgtacag      300

atgtccatga tcatctacaa ctgtctgaag gaagaaagga agattttgga aaatgcccaa      360

agatttaatc aggcccagga gggaaatatt cagaacactg tgatgttaga taaacagaag      420

gagctggaca gtaaagtcag aaatgtgaag gatcaagtca tgtgcataga gcaggaaatc      480

aagaccctag aagaattaca agatgaatat gactttaaat gcaaaacctc tcagaacaga      540

gaaggtgaag ccaatggtgt ggcgaagagc gaccaaaaac aggaacagct gctgctccac      600

aagatgtttt taatgcttga caataagaga aaggagataa ttcacaaaat cagagagttg      660

ctgaattcca tcgagctcac tcagaacact ctgattaatg acgagctcgt ggagtggaag      720

cgaaggcagc agagcgcctg catcggggga ccgcccaacg cctgcctgga tcagctgcaa      780

agctggttca ccattgttgc agagaccctg cagcagatcc gtcagcagct taaaaagctg      840

gaggagttgg aacagaaatt cacctatgag cccgacccta ttacaaaaaa caagcaggtg      900

ttgtcagatc gaaccttcct cctcttccag cagctcattc agagctcctt cgtggtagaa      960

cgacagccgt gcatgcccac tcacccgcag aggcccctgg tcttgaagac tggggtacag     1020

ttcactgtca agctgagact gttggtgaaa ttgcaagagc tgaactataa cttgaaagtg     1080

aaagtctcat ttgacaaaga tgtgaacgag aaaaacacag ttaaaggatt tcggaagttc     1140

aacatcttgg gtacgcacac aaaagtgatg aacatggaag aatccaccaa cggaagtctg     1200

gcagctgagt tccgacacct gcaactgaag gaacagaaaa acgctgggaa cagaactaat     1260

gaggggcctc tcattgtcac cgaagaactt cactctctta gctttgaaac ccagttgtgc     1320

cagccaggct tggtgattga cctggaggtc tttgttccct ttcagaccac ctctcttcct     1380

gtcgtggtga tctccaacgt cagccagctc cccagtggct gggcgtctat cctgtggtac     1440

aacatgctgg tgacagagcc caggaatctc tccttcttcc tgaacccccc gtgcgcgtgg     1500

tggtcccagc tctcagaggt gttgagttgg cagttttcat cagtcaccaa gagaggtctg     1560

aacgcagacc agctgagcat gctgggagag aagctgctgg gccctaatgc tggccctgat     1620

ggtcttattc catggacaag gttttgtaag gaaaatatta atgataaaaa tttctccttc     1680

tggccttgga ttgacaccat cctagagctc attaagaagc acctgctgtg cctctggaat     1740

gatgggtgca ttatgggctt catcagcaag gagcgagaac gcgctctgct caaggaccag     1800

cagccaggga cgttcctgct tagattcagt gagagctccc gggaaggggc catcacattc     1860

acatgggtgg aacggtccca gaacggaggt gaacctgact tccatgccgt ggagccctac     1920

acgaaaaaag aactttcagc tgttactttc ccagatatta ttcgcaacta caaagtcatg     1980

gcttgcgagt gcataccaga gaatcccctg aagtatctgt accccaatat tgacaaagac     2040

cacgcctttg ggaagtatta ttccagacca aaggaagcac cagaaccgat ggagcttgac     2100

gaccctaagc gaactggata catcaagact gagttgattt ctgtgtctga agtccaccct     2160

tctagacttc agaccacaga caacctgctt cccatgtctc cagaggagtt tgatgagatg     2220

tcccggatag tgggccccga atttgacagt atgatgagca cagtataa                  2268


<210>  3
<211>  750
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ser Gln Trp Tyr Glu Leu Gln Gln Leu Asp Ser Lys Phe Leu Glu 
1               5                   10                  15      


Gln Val His Gln Leu Tyr Asp Asp Ser Phe Pro Met Glu Ile Arg Gln 
            20                  25                  30          


Tyr Leu Ala Gln Trp Leu Glu Lys Gln Asp Trp Glu His Ala Ala Asn 
        35                  40                  45              


Asp Val Ser Phe Ala Thr Ile Arg Phe His Asp Leu Leu Ser Gln Leu 
    50                  55                  60                  


Asp Asp Gln Tyr Ser Arg Phe Ser Leu Glu Asn Asn Phe Leu Leu Gln 
65                  70                  75                  80  


His Asn Ile Arg Lys Ser Lys Arg Asn Leu Gln Asp Asn Phe Gln Glu 
                85                  90                  95      


Asp Pro Ile Gln Met Ser Met Ile Ile Tyr Ser Cys Leu Lys Glu Glu 
            100                 105                 110         


Arg Lys Ile Leu Glu Asn Ala Gln Arg Phe Asn Gln Ala Gln Ser Gly 
        115                 120                 125             


Asn Ile Gln Ser Thr Val Met Leu Asp Lys Gln Lys Glu Leu Asp Ser 
    130                 135                 140                 


Lys Val Arg Asn Val Lys Asp Lys Val Met Cys Ile Glu His Glu Ile 
145                 150                 155                 160 


Lys Ser Leu Glu Asp Leu Gln Asp Glu Tyr Asp Phe Lys Cys Lys Thr 
                165                 170                 175     


Leu Gln Asn Arg Glu His Glu Thr Asn Gly Val Ala Lys Ser Asp Gln 
            180                 185                 190         


Lys Gln Glu Gln Leu Leu Leu Lys Lys Met Tyr Leu Met Leu Asp Asn 
        195                 200                 205             


Lys Arg Lys Glu Val Val His Lys Ile Ile Glu Leu Leu Asn Val Thr 
    210                 215                 220                 


Glu Leu Thr Gln Asn Ala Leu Ile Asn Asp Glu Leu Val Glu Trp Lys 
225                 230                 235                 240 


Arg Arg Gln Gln Ser Ala Cys Ile Gly Gly Pro Pro Asn Ala Cys Leu 
                245                 250                 255     


Asp Gln Leu Gln Asn Trp Phe Thr Ile Val Ala Glu Ser Leu Gln Gln 
            260                 265                 270         


Val Arg Gln Gln Leu Lys Lys Leu Glu Glu Leu Glu Gln Lys Tyr Thr 
        275                 280                 285             


Tyr Glu His Asp Pro Ile Thr Lys Asn Lys Gln Val Leu Trp Asp Arg 
    290                 295                 300                 


Thr Phe Ser Leu Phe Gln Gln Leu Ile Gln Ser Ser Phe Val Val Glu 
305                 310                 315                 320 


Arg Gln Pro Cys Met Pro Thr His Pro Gln Arg Pro Leu Val Leu Lys 
                325                 330                 335     


Thr Gly Val Gln Phe Thr Val Lys Leu Arg Leu Leu Val Lys Leu Gln 
            340                 345                 350         


Glu Leu Asn Tyr Asn Leu Lys Val Lys Val Leu Phe Asp Lys Asp Val 
        355                 360                 365             


Asn Glu Arg Asn Thr Val Lys Gly Phe Arg Lys Phe Asn Ile Leu Gly 
    370                 375                 380                 


Thr His Thr Lys Val Met Asn Met Glu Glu Ser Thr Asn Gly Ser Leu 
385                 390                 395                 400 


Ala Ala Glu Phe Arg His Leu Gln Leu Lys Glu Gln Lys Asn Ala Gly 
                405                 410                 415     


Thr Arg Thr Asn Glu Gly Pro Leu Ile Val Thr Glu Glu Leu His Ser 
            420                 425                 430         


Leu Ser Phe Glu Thr Gln Leu Cys Gln Pro Gly Leu Val Ile Asp Leu 
        435                 440                 445             


Glu Thr Thr Ser Leu Pro Val Val Val Ile Ser Asn Val Ser Gln Leu 
    450                 455                 460                 


Pro Ser Gly Trp Ala Ser Ile Leu Trp Tyr Asn Met Leu Val Ala Glu 
465                 470                 475                 480 


Pro Arg Asn Leu Ser Phe Phe Leu Thr Pro Pro Cys Ala Arg Trp Ala 
                485                 490                 495     


Gln Leu Ser Glu Val Leu Ser Trp Gln Phe Ser Ser Val Thr Lys Arg 
            500                 505                 510         


Gly Leu Asn Val Asp Gln Leu Asn Met Leu Gly Glu Lys Leu Leu Gly 
        515                 520                 525             


Pro Asn Ala Ser Pro Asp Gly Leu Ile Pro Trp Thr Arg Phe Cys Lys 
    530                 535                 540                 


Glu Asn Ile Asn Asp Lys Asn Phe Pro Phe Trp Leu Trp Ile Glu Ser 
545                 550                 555                 560 


Ile Leu Glu Leu Ile Lys Lys His Leu Leu Pro Leu Trp Asn Asp Gly 
                565                 570                 575     


Cys Ile Met Gly Phe Ile Ser Lys Glu Arg Glu Arg Ala Leu Leu Lys 
            580                 585                 590         


Asp Gln Gln Pro Gly Thr Phe Leu Leu Arg Phe Ser Glu Ser Ser Arg 
        595                 600                 605             


Glu Gly Ala Ile Thr Phe Thr Trp Val Glu Arg Ser Gln Asn Gly Gly 
    610                 615                 620                 


Glu Pro Asp Phe His Ala Val Glu Pro Tyr Thr Lys Lys Glu Leu Ser 
625                 630                 635                 640 


Ala Val Thr Phe Pro Asp Ile Ile Arg Asn Tyr Lys Val Met Ala Cys 
                645                 650                 655     


Glu Cys Ile Pro Glu Asn Pro Leu Lys Tyr Leu Tyr Pro Asn Ile Asp 
            660                 665                 670         


Lys Asp His Ala Phe Gly Lys Tyr Tyr Ser Arg Pro Lys Glu Ala Pro 
        675                 680                 685             


Glu Pro Met Glu Leu Asp Gly Pro Lys Gly Thr Gly Tyr Ile Lys Thr 
    690                 695                 700                 


Glu Leu Ile Ser Val Ser Glu Val His Pro Ser Arg Leu Gln Thr Thr 
705                 710                 715                 720 


Asp Asn Leu Leu Pro Met Ser Pro Glu Glu Phe Asp Glu Val Ser Arg 
                725                 730                 735     


Ile Val Gly Ser Val Glu Phe Asp Ser Met Met Asn Thr Val 
            740                 745                 750 


<210>  4
<211>  749
<212>  PRT
<213>  Mus musculus

<400>  4

Met Ser Gln Trp Phe Glu Leu Gln Gln Leu Asp Ser Lys Phe Leu Glu 
1               5                   10                  15      


Gln Val His Gln Leu Tyr Asp Asp Ser Phe Pro Met Glu Ile Arg Gln 
            20                  25                  30          


Tyr Leu Ala Gln Trp Leu Glu Lys Gln Asp Trp Glu His Ala Ala Tyr 
        35                  40                  45              


Asp Val Ser Phe Ala Thr Ile Arg Phe His Asp Leu Leu Ser Gln Leu 
    50                  55                  60                  


Asp Asp Gln Tyr Ser Arg Phe Ser Leu Glu Asn Asn Phe Leu Leu Gln 
65                  70                  75                  80  


His Asn Ile Arg Lys Ser Lys Arg Asn Leu Gln Asp Asn Phe Gln Glu 
                85                  90                  95      


Asp Pro Val Gln Met Ser Met Ile Ile Tyr Asn Cys Leu Lys Glu Glu 
            100                 105                 110         


Arg Lys Ile Leu Glu Asn Ala Gln Arg Phe Asn Gln Ala Gln Glu Gly 
        115                 120                 125             


Asn Ile Gln Asn Thr Val Met Leu Asp Lys Gln Lys Glu Leu Asp Ser 
    130                 135                 140                 


Lys Val Arg Asn Val Lys Asp Gln Val Met Cys Ile Glu Gln Glu Ile 
145                 150                 155                 160 


Lys Thr Leu Glu Glu Leu Gln Asp Glu Tyr Asp Phe Lys Cys Lys Thr 
                165                 170                 175     


Ser Gln Asn Arg Glu Gly Glu Ala Asn Gly Val Ala Lys Ser Asp Gln 
            180                 185                 190         


Lys Gln Glu Gln Leu Leu Leu His Lys Met Phe Leu Met Leu Asp Asn 
        195                 200                 205             


Lys Arg Lys Glu Ile Ile His Lys Ile Arg Glu Leu Leu Asn Ser Ile 
    210                 215                 220                 


Glu Leu Thr Gln Asn Thr Leu Ile Asn Asp Glu Leu Val Glu Trp Lys 
225                 230                 235                 240 


Arg Arg Gln Gln Ser Ala Cys Ile Gly Gly Pro Pro Asn Ala Cys Leu 
                245                 250                 255     


Asp Gln Leu Gln Ser Trp Phe Thr Ile Val Ala Glu Thr Leu Gln Gln 
            260                 265                 270         


Ile Arg Gln Gln Leu Lys Lys Leu Glu Glu Leu Glu Gln Lys Phe Thr 
        275                 280                 285             


Tyr Glu Pro Asp Pro Ile Thr Lys Asn Lys Gln Val Leu Ser Asp Arg 
    290                 295                 300                 


Thr Phe Leu Leu Phe Gln Gln Leu Ile Gln Ser Ser Phe Val Val Glu 
305                 310                 315                 320 


Arg Gln Pro Cys Met Pro Thr His Pro Gln Arg Pro Leu Val Leu Lys 
                325                 330                 335     


Thr Gly Val Gln Phe Thr Val Lys Leu Arg Leu Leu Val Lys Leu Gln 
            340                 345                 350         


Glu Leu Asn Tyr Asn Leu Lys Val Lys Val Ser Phe Asp Lys Asp Val 
        355                 360                 365             


Asn Glu Lys Asn Thr Val Lys Gly Phe Arg Lys Phe Asn Ile Leu Gly 
    370                 375                 380                 


Thr His Thr Lys Val Met Asn Met Glu Glu Ser Thr Asn Gly Ser Leu 
385                 390                 395                 400 


Ala Ala Glu Phe Arg His Leu Gln Leu Lys Glu Gln Lys Asn Ala Gly 
                405                 410                 415     


Asn Arg Thr Asn Glu Gly Pro Leu Ile Val Thr Glu Glu Leu His Ser 
            420                 425                 430         


Leu Ser Phe Glu Thr Gln Leu Cys Gln Pro Gly Leu Val Ile Asp Leu 
        435                 440                 445             


Glu Thr Thr Ser Leu Pro Val Val Val Ile Ser Asn Val Ser Gln Leu 
    450                 455                 460                 


Pro Ser Gly Trp Ala Ser Ile Leu Trp Tyr Asn Met Leu Val Thr Glu 
465                 470                 475                 480 


Pro Arg Asn Leu Ser Phe Phe Leu Asn Pro Pro Cys Ala Trp Trp Ser 
                485                 490                 495     


Gln Leu Ser Glu Val Leu Ser Trp Gln Phe Ser Ser Val Thr Lys Arg 
            500                 505                 510         


Gly Leu Asn Ala Asp Gln Leu Ser Met Leu Gly Glu Lys Leu Leu Gly 
        515                 520                 525             


Pro Asn Ala Gly Pro Asp Gly Leu Ile Pro Trp Thr Arg Phe Cys Lys 
    530                 535                 540                 


Glu Asn Ile Asn Asp Lys Asn Phe Ser Phe Trp Pro Trp Ile Asp Thr 
545                 550                 555                 560 


Ile Leu Glu Leu Ile Lys Lys His Leu Leu Cys Leu Trp Asn Asp Gly 
                565                 570                 575     


Cys Ile Met Gly Phe Ile Ser Lys Glu Arg Glu Arg Ala Leu Leu Lys 
            580                 585                 590         


Asp Gln Gln Pro Gly Thr Phe Leu Leu Arg Phe Ser Glu Ser Ser Arg 
        595                 600                 605             


Glu Gly Ala Ile Thr Phe Thr Trp Val Glu Arg Ser Gln Asn Gly Gly 
    610                 615                 620                 


Glu Pro Asp Phe His Ala Val Glu Pro Tyr Thr Lys Lys Glu Leu Ser 
625                 630                 635                 640 


Ala Val Thr Phe Pro Asp Ile Ile Arg Asn Tyr Lys Val Met Ala Cys 
                645                 650                 655     


Glu Cys Ile Pro Glu Asn Pro Leu Lys Tyr Leu Tyr Pro Asn Ile Asp 
            660                 665                 670         


Lys Asp His Ala Phe Gly Lys Tyr Tyr Ser Arg Pro Lys Glu Ala Pro 
        675                 680                 685             


Glu Pro Met Glu Leu Asp Asp Pro Lys Arg Thr Gly Tyr Ile Lys Thr 
    690                 695                 700                 


Glu Leu Ile Ser Val Ser Glu Val His Pro Ser Arg Leu Gln Thr Thr 
705                 710                 715                 720 


Asp Asn Leu Leu Pro Met Ser Pro Glu Glu Phe Asp Glu Met Ser Arg 
                725                 730                 735     


Ile Val Gly Pro Glu Phe Asp Ser Met Met Ser Thr Val 
            740                 745                 


<210>  5
<211>  750
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ser Gln Trp Tyr Glu Leu Gln Gln Leu Asp Ser Lys Phe Leu Glu 
1               5                   10                  15      


Gln Val His Gln Leu Tyr Asp Asp Ser Phe Pro Met Glu Ile Arg Gln 
            20                  25                  30          


Tyr Leu Ala Gln Trp Leu Glu Lys Gln Asp Trp Glu His Ala Ala Asn 
        35                  40                  45              


Asp Val Ser Phe Ala Thr Ile Arg Phe His Asp Leu Leu Ser Gln Leu 
    50                  55                  60                  


Asp Asp Gln Tyr Ser Arg Phe Ser Leu Glu Asn Asn Phe Leu Leu Gln 
65                  70                  75                  80  


His Asn Ile Arg Lys Ser Lys Arg Asn Leu Gln Asp Asn Phe Gln Glu 
                85                  90                  95      


Asp Pro Ile Gln Met Ser Met Ile Ile Tyr Ser Cys Leu Lys Glu Glu 
            100                 105                 110         


Arg Lys Ile Leu Glu Asn Ala Gln Arg Phe Asn Gln Ala Gln Ser Gly 
        115                 120                 125             


Asn Ile Gln Ser Thr Val Met Leu Asp Lys Gln Lys Glu Leu Asp Ser 
    130                 135                 140                 


Lys Val Arg Asn Val Lys Asp Lys Val Met Cys Ile Glu His Glu Ile 
145                 150                 155                 160 


Lys Ser Leu Glu Asp Leu Gln Asp Glu Tyr Asp Phe Lys Cys Lys Thr 
                165                 170                 175     


Leu Gln Asn Arg Glu His Glu Thr Asn Gly Val Ala Lys Ser Asp Gln 
            180                 185                 190         


Lys Gln Glu Gln Leu Leu Leu Lys Lys Met Tyr Leu Met Leu Asp Asn 
        195                 200                 205             


Lys Arg Lys Glu Val Val His Lys Ile Ile Glu Leu Leu Asn Val Thr 
    210                 215                 220                 


Glu Leu Thr Gln Asn Ala Leu Ile Asn Asp Glu Leu Val Glu Trp Lys 
225                 230                 235                 240 


Arg Arg Gln Gln Ser Ala Cys Ile Gly Gly Pro Pro Asn Ala Cys Leu 
                245                 250                 255     


Asp Gln Leu Gln Asn Trp Phe Thr Ile Val Ala Glu Ser Leu Gln Gln 
            260                 265                 270         


Val Arg Gln Gln Leu Lys Lys Leu Glu Glu Leu Glu Gln Lys Tyr Thr 
        275                 280                 285             


Tyr Glu His Asp Pro Ile Thr Lys Asn Lys Gln Val Leu Trp Asp Arg 
    290                 295                 300                 


Thr Phe Ser Leu Phe Gln Gln Leu Ile Gln Ser Ser Phe Val Val Glu 
305                 310                 315                 320 


Arg Gln Pro Cys Met Pro Thr His Pro Gln Arg Pro Leu Val Leu Lys 
                325                 330                 335     


Thr Gly Val Gln Phe Thr Val Lys Leu Arg Leu Leu Val Lys Leu Gln 
            340                 345                 350         


Glu Leu Asn Tyr Asn Leu Lys Val Lys Val Leu Phe Asp Lys Asp Val 
        355                 360                 365             


Asn Glu Arg Asn Thr Val Lys Gly Phe Arg Lys Phe Asn Ile Leu Gly 
    370                 375                 380                 


Thr His Thr Lys Val Met Asn Met Glu Glu Ser Thr Asn Gly Ser Leu 
385                 390                 395                 400 


Ala Ala Glu Phe Arg His Leu Gln Leu Lys Glu Gln Lys Asn Ala Gly 
                405                 410                 415     


Thr Arg Thr Asn Glu Gly Pro Leu Ile Val Thr Glu Glu Leu His Ser 
            420                 425                 430         


Leu Ser Phe Glu Thr Gln Leu Cys Gln Pro Gly Leu Val Ile Asp Leu 
        435                 440                 445             


Glu Thr Thr Ser Leu Pro Val Val Val Ile Ser Asn Val Ser Gln Leu 
    450                 455                 460                 


Pro Ser Gly Trp Ala Ser Ile Leu Trp Tyr Asn Met Leu Val Ala Glu 
465                 470                 475                 480 


Pro Arg Asn Leu Ser Phe Phe Leu Thr Pro Pro Cys Ala Arg Trp Ala 
                485                 490                 495     


Gln Leu Ser Glu Val Leu Ser Trp Gln Phe Ser Ser Val Thr Lys Arg 
            500                 505                 510         


Gly Leu Asn Val Asp Gln Leu Asn Met Leu Gly Glu Lys Leu Leu Gly 
        515                 520                 525             


Pro Asn Ala Ser Pro Asp Gly Leu Ile Pro Trp Thr Arg Phe Cys Lys 
    530                 535                 540                 


Glu Asn Ile Asn Asp Lys Asn Phe Pro Phe Trp Leu Trp Ile Glu Ser 
545                 550                 555                 560 


Ile Leu Glu Leu Ile Lys Lys His Leu Leu Pro Leu Trp Asn Asp Gly 
                565                 570                 575     


Cys Ile Met Gly Phe Ile Ser Lys Glu Arg Glu Arg Ala Leu Leu Lys 
            580                 585                 590         


Asp Gln Gln Pro Gly Thr Phe Leu Leu Arg Phe Ser Glu Ser Ser Arg 
        595                 600                 605             


Glu Gly Ala Ile Thr Phe Thr Trp Val Glu Arg Ser Gln Asn Gly Gly 
    610                 615                 620                 


Glu Pro Asp Phe His Ala Val Glu Pro Tyr Thr Lys Lys Glu Leu Ser 
625                 630                 635                 640 


Ala Val Thr Phe Pro Asp Ile Ile Arg Asn Tyr Lys Val Met Ala Ala 
                645                 650                 655     


Glu Asn Ile Pro Glu Asn Pro Leu Lys Tyr Leu Tyr Pro Asn Ile Asp 
            660                 665                 670         


Lys Asp His Ala Phe Gly Lys Tyr Tyr Ser Arg Pro Lys Glu Ala Pro 
        675                 680                 685             


Glu Pro Met Glu Leu Asp Gly Pro Lys Gly Thr Gly Tyr Ile Lys Thr 
    690                 695                 700                 


Glu Leu Ile Ser Val Ser Glu Val His Pro Ser Arg Leu Gln Thr Thr 
705                 710                 715                 720 


Asp Asn Leu Leu Pro Met Ser Pro Glu Glu Phe Asp Glu Val Ser Arg 
                725                 730                 735     


Ile Val Gly Ser Val Glu Phe Asp Ser Met Met Asn Thr Val 
            740                 745                 750 


<210>  6
<211>  712
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ser Gln Trp Tyr Glu Leu Gln Gln Leu Asp Ser Lys Phe Leu Glu 
1               5                   10                  15      


Gln Val His Gln Leu Tyr Asp Asp Ser Phe Pro Met Glu Ile Arg Gln 
            20                  25                  30          


Tyr Leu Ala Gln Trp Leu Glu Lys Gln Asp Trp Glu His Ala Ala Asn 
        35                  40                  45              


Asp Val Ser Phe Ala Thr Ile Arg Phe His Asp Leu Leu Ser Gln Leu 
    50                  55                  60                  


Asp Asp Gln Tyr Ser Arg Phe Ser Leu Glu Asn Asn Phe Leu Leu Gln 
65                  70                  75                  80  


His Asn Ile Arg Lys Ser Lys Arg Asn Leu Gln Asp Asn Phe Gln Glu 
                85                  90                  95      


Asp Pro Ile Gln Met Ser Met Ile Ile Tyr Ser Cys Leu Lys Glu Glu 
            100                 105                 110         


Arg Lys Ile Leu Glu Asn Ala Gln Arg Phe Asn Gln Ala Gln Ser Gly 
        115                 120                 125             


Asn Ile Gln Ser Thr Val Met Leu Asp Lys Gln Lys Glu Leu Asp Ser 
    130                 135                 140                 


Lys Val Arg Asn Val Lys Asp Lys Val Met Cys Ile Glu His Glu Ile 
145                 150                 155                 160 


Lys Ser Leu Glu Asp Leu Gln Asp Glu Tyr Asp Phe Lys Cys Lys Thr 
                165                 170                 175     


Leu Gln Asn Arg Glu His Glu Thr Asn Gly Val Ala Lys Ser Asp Gln 
            180                 185                 190         


Lys Gln Glu Gln Leu Leu Leu Lys Lys Met Tyr Leu Met Leu Asp Asn 
        195                 200                 205             


Lys Arg Lys Glu Val Val His Lys Ile Ile Glu Leu Leu Asn Val Thr 
    210                 215                 220                 


Glu Leu Thr Gln Asn Ala Leu Ile Asn Asp Glu Leu Val Glu Trp Lys 
225                 230                 235                 240 


Arg Arg Gln Gln Ser Ala Cys Ile Gly Gly Pro Pro Asn Ala Cys Leu 
                245                 250                 255     


Asp Gln Leu Gln Asn Trp Phe Thr Ile Val Ala Glu Ser Leu Gln Gln 
            260                 265                 270         


Val Arg Gln Gln Leu Lys Lys Leu Glu Glu Leu Glu Gln Lys Tyr Thr 
        275                 280                 285             


Tyr Glu His Asp Pro Ile Thr Lys Asn Lys Gln Val Leu Trp Asp Arg 
    290                 295                 300                 


Thr Phe Ser Leu Phe Gln Gln Leu Ile Gln Ser Ser Phe Val Val Glu 
305                 310                 315                 320 


Arg Gln Pro Cys Met Pro Thr His Pro Gln Arg Pro Leu Val Leu Lys 
                325                 330                 335     


Thr Gly Val Gln Phe Thr Val Lys Leu Arg Leu Leu Val Lys Leu Gln 
            340                 345                 350         


Glu Leu Asn Tyr Asn Leu Lys Val Lys Val Leu Phe Asp Lys Asp Val 
        355                 360                 365             


Asn Glu Arg Asn Thr Val Lys Gly Phe Arg Lys Phe Asn Ile Leu Gly 
    370                 375                 380                 


Thr His Thr Lys Val Met Asn Met Glu Glu Ser Thr Asn Gly Ser Leu 
385                 390                 395                 400 


Ala Ala Glu Phe Arg His Leu Gln Leu Lys Glu Gln Lys Asn Ala Gly 
                405                 410                 415     


Thr Arg Thr Asn Glu Gly Pro Leu Ile Val Thr Glu Glu Leu His Ser 
            420                 425                 430         


Leu Ser Phe Glu Thr Gln Leu Cys Gln Pro Gly Leu Val Ile Asp Leu 
        435                 440                 445             


Glu Thr Thr Ser Leu Pro Val Val Val Ile Ser Asn Val Ser Gln Leu 
    450                 455                 460                 


Pro Ser Gly Trp Ala Ser Ile Leu Trp Tyr Asn Met Leu Val Ala Glu 
465                 470                 475                 480 


Pro Arg Asn Leu Ser Phe Phe Leu Thr Pro Pro Cys Ala Arg Trp Ala 
                485                 490                 495     


Gln Leu Ser Glu Val Leu Ser Trp Gln Phe Ser Ser Val Thr Lys Arg 
            500                 505                 510         


Gly Leu Asn Val Asp Gln Leu Asn Met Leu Gly Glu Lys Leu Leu Gly 
        515                 520                 525             


Pro Asn Ala Ser Pro Asp Gly Leu Ile Pro Trp Thr Arg Phe Cys Lys 
    530                 535                 540                 


Glu Asn Ile Asn Asp Lys Asn Phe Pro Phe Trp Leu Trp Ile Glu Ser 
545                 550                 555                 560 


Ile Leu Glu Leu Ile Lys Lys His Leu Leu Pro Leu Trp Asn Asp Gly 
                565                 570                 575     


Cys Ile Met Gly Phe Ile Ser Lys Glu Arg Glu Arg Ala Leu Leu Lys 
            580                 585                 590         


Asp Gln Gln Pro Gly Thr Phe Leu Leu Arg Phe Ser Glu Ser Ser Arg 
        595                 600                 605             


Glu Gly Ala Ile Thr Phe Thr Trp Val Glu Arg Ser Gln Asn Gly Gly 
    610                 615                 620                 


Glu Pro Asp Phe His Ala Val Glu Pro Tyr Thr Lys Lys Glu Leu Ser 
625                 630                 635                 640 


Ala Val Thr Phe Pro Asp Ile Ile Arg Asn Tyr Lys Val Met Ala Ala 
                645                 650                 655     


Glu Asn Ile Pro Glu Asn Pro Leu Lys Tyr Leu Tyr Pro Asn Ile Asp 
            660                 665                 670         


Lys Asp His Ala Phe Gly Lys Tyr Tyr Ser Arg Pro Lys Glu Ala Pro 
        675                 680                 685             


Glu Pro Met Glu Leu Asp Gly Pro Lys Gly Thr Gly Tyr Ile Lys Thr 
    690                 695                 700                 


Glu Leu Ile Ser Val Ser Glu Val 
705                 710         


<210>  7
<211>  755
<212>  PRT
<213>  Mus musculus

<400>  7

Met Ser Gln Trp Phe Glu Leu Gln Gln Leu Asp Ser Lys Phe Leu Glu 
1               5                   10                  15      


Gln Val His Gln Leu Tyr Asp Asp Ser Phe Pro Met Glu Ile Arg Gln 
            20                  25                  30          


Tyr Leu Ala Gln Trp Leu Glu Lys Gln Asp Trp Glu His Ala Ala Tyr 
        35                  40                  45              


Asp Val Ser Phe Ala Thr Ile Arg Phe His Asp Leu Leu Ser Gln Leu 
    50                  55                  60                  


Asp Asp Gln Tyr Ser Arg Phe Ser Leu Glu Asn Asn Phe Leu Leu Gln 
65                  70                  75                  80  


His Asn Ile Arg Lys Ser Lys Arg Asn Leu Gln Asp Asn Phe Gln Glu 
                85                  90                  95      


Asp Pro Val Gln Met Ser Met Ile Ile Tyr Asn Cys Leu Lys Glu Glu 
            100                 105                 110         


Arg Lys Ile Leu Glu Asn Ala Gln Arg Phe Asn Gln Ala Gln Glu Gly 
        115                 120                 125             


Asn Ile Gln Asn Thr Val Met Leu Asp Lys Gln Lys Glu Leu Asp Ser 
    130                 135                 140                 


Lys Val Arg Asn Val Lys Asp Gln Val Met Cys Ile Glu Gln Glu Ile 
145                 150                 155                 160 


Lys Thr Leu Glu Glu Leu Gln Asp Glu Tyr Asp Phe Lys Cys Lys Thr 
                165                 170                 175     


Ser Gln Asn Arg Glu Gly Glu Ala Asn Gly Val Ala Lys Ser Asp Gln 
            180                 185                 190         


Lys Gln Glu Gln Leu Leu Leu His Lys Met Phe Leu Met Leu Asp Asn 
        195                 200                 205             


Lys Arg Lys Glu Ile Ile His Lys Ile Arg Glu Leu Leu Asn Ser Ile 
    210                 215                 220                 


Glu Leu Thr Gln Asn Thr Leu Ile Asn Asp Glu Leu Val Glu Trp Lys 
225                 230                 235                 240 


Arg Arg Gln Gln Ser Ala Cys Ile Gly Gly Pro Pro Asn Ala Cys Leu 
                245                 250                 255     


Asp Gln Leu Gln Ser Trp Phe Thr Ile Val Ala Glu Thr Leu Gln Gln 
            260                 265                 270         


Ile Arg Gln Gln Leu Lys Lys Leu Glu Glu Leu Glu Gln Lys Phe Thr 
        275                 280                 285             


Tyr Glu Pro Asp Pro Ile Thr Lys Asn Lys Gln Val Leu Ser Asp Arg 
    290                 295                 300                 


Thr Phe Leu Leu Phe Gln Gln Leu Ile Gln Ser Ser Phe Val Val Glu 
305                 310                 315                 320 


Arg Gln Pro Cys Met Pro Thr His Pro Gln Arg Pro Leu Val Leu Lys 
                325                 330                 335     


Thr Gly Val Gln Phe Thr Val Lys Leu Arg Leu Leu Val Lys Leu Gln 
            340                 345                 350         


Glu Leu Asn Tyr Asn Leu Lys Val Lys Val Ser Phe Asp Lys Asp Val 
        355                 360                 365             


Asn Glu Lys Asn Thr Val Lys Gly Phe Arg Lys Phe Asn Ile Leu Gly 
    370                 375                 380                 


Thr His Thr Lys Val Met Asn Met Glu Glu Ser Thr Asn Gly Ser Leu 
385                 390                 395                 400 


Ala Ala Glu Phe Arg His Leu Gln Leu Lys Glu Gln Lys Asn Ala Gly 
                405                 410                 415     


Asn Arg Thr Asn Glu Gly Pro Leu Ile Val Thr Glu Glu Leu His Ser 
            420                 425                 430         


Leu Ser Phe Glu Thr Gln Leu Cys Gln Pro Gly Leu Val Ile Asp Leu 
        435                 440                 445             


Glu Val Phe Val Pro Phe Gln Thr Thr Ser Leu Pro Val Val Val Ile 
    450                 455                 460                 


Ser Asn Val Ser Gln Leu Pro Ser Gly Trp Ala Ser Ile Leu Trp Tyr 
465                 470                 475                 480 


Asn Met Leu Val Thr Glu Pro Arg Asn Leu Ser Phe Phe Leu Asn Pro 
                485                 490                 495     


Pro Cys Ala Trp Trp Ser Gln Leu Ser Glu Val Leu Ser Trp Gln Phe 
            500                 505                 510         


Ser Ser Val Thr Lys Arg Gly Leu Asn Ala Asp Gln Leu Ser Met Leu 
        515                 520                 525             


Gly Glu Lys Leu Leu Gly Pro Asn Ala Gly Pro Asp Gly Leu Ile Pro 
    530                 535                 540                 


Trp Thr Arg Phe Cys Lys Glu Asn Ile Asn Asp Lys Asn Phe Ser Phe 
545                 550                 555                 560 


Trp Pro Trp Ile Asp Thr Ile Leu Glu Leu Ile Lys Lys His Leu Leu 
                565                 570                 575     


Cys Leu Trp Asn Asp Gly Cys Ile Met Gly Phe Ile Ser Lys Glu Arg 
            580                 585                 590         


Glu Arg Ala Leu Leu Lys Asp Gln Gln Pro Gly Thr Phe Leu Leu Arg 
        595                 600                 605             


Phe Ser Glu Ser Ser Arg Glu Gly Ala Ile Thr Phe Thr Trp Val Glu 
    610                 615                 620                 


Arg Ser Gln Asn Gly Gly Glu Pro Asp Phe His Ala Val Glu Pro Tyr 
625                 630                 635                 640 


Thr Lys Lys Glu Leu Ser Ala Val Thr Phe Pro Asp Ile Ile Arg Asn 
                645                 650                 655     


Tyr Lys Val Met Ala Ala Glu Asn Ile Pro Glu Asn Pro Leu Lys Tyr 
            660                 665                 670         


Leu Tyr Pro Asn Ile Asp Lys Asp His Ala Phe Gly Lys Tyr Tyr Ser 
        675                 680                 685             


Arg Pro Lys Glu Ala Pro Glu Pro Met Glu Leu Asp Asp Pro Lys Arg 
    690                 695                 700                 


Thr Gly Tyr Ile Lys Thr Glu Leu Ile Ser Val Ser Glu Val His Pro 
705                 710                 715                 720 


Ser Arg Leu Gln Thr Thr Asp Asn Leu Leu Pro Met Ser Pro Glu Glu 
                725                 730                 735     


Phe Asp Glu Met Ser Arg Ile Val Gly Pro Glu Phe Asp Ser Met Met 
            740                 745                 750         


Ser Thr Val 
        755 


<210>  8
<211>  749
<212>  PRT
<213>  Mus musculus

<400>  8

Met Ser Gln Trp Phe Glu Leu Gln Gln Leu Asp Ser Lys Phe Leu Glu 
1               5                   10                  15      


Gln Val His Gln Leu Tyr Asp Asp Ser Phe Pro Met Glu Ile Arg Gln 
            20                  25                  30          


Tyr Leu Ala Gln Trp Leu Glu Lys Gln Asp Trp Glu His Ala Ala Tyr 
        35                  40                  45              


Asp Val Ser Phe Ala Thr Ile Arg Phe His Asp Leu Leu Ser Gln Leu 
    50                  55                  60                  


Asp Asp Gln Tyr Ser Arg Phe Ser Leu Glu Asn Asn Phe Leu Leu Gln 
65                  70                  75                  80  


His Asn Ile Arg Lys Ser Lys Arg Asn Leu Gln Asp Asn Phe Gln Glu 
                85                  90                  95      


Asp Pro Val Gln Met Ser Met Ile Ile Tyr Asn Cys Leu Lys Glu Glu 
            100                 105                 110         


Arg Lys Ile Leu Glu Asn Ala Gln Arg Phe Asn Gln Ala Gln Glu Gly 
        115                 120                 125             


Asn Ile Gln Asn Thr Val Met Leu Asp Lys Gln Lys Glu Leu Asp Ser 
    130                 135                 140                 


Lys Val Arg Asn Val Lys Asp Gln Val Met Cys Ile Glu Gln Glu Ile 
145                 150                 155                 160 


Lys Thr Leu Glu Glu Leu Gln Asp Glu Tyr Asp Phe Lys Cys Lys Thr 
                165                 170                 175     


Ser Gln Asn Arg Glu Gly Glu Ala Asn Gly Val Ala Lys Ser Asp Gln 
            180                 185                 190         


Lys Gln Glu Gln Leu Leu Leu His Lys Met Phe Leu Met Leu Asp Asn 
        195                 200                 205             


Lys Arg Lys Glu Ile Ile His Lys Ile Arg Glu Leu Leu Asn Ser Ile 
    210                 215                 220                 


Glu Leu Thr Gln Asn Thr Leu Ile Asn Asp Glu Leu Val Glu Trp Lys 
225                 230                 235                 240 


Arg Arg Gln Gln Ser Ala Cys Ile Gly Gly Pro Pro Asn Ala Cys Leu 
                245                 250                 255     


Asp Gln Leu Gln Ser Trp Phe Thr Ile Val Ala Glu Thr Leu Gln Gln 
            260                 265                 270         


Ile Arg Gln Gln Leu Lys Lys Leu Glu Glu Leu Glu Gln Lys Phe Thr 
        275                 280                 285             


Tyr Glu Pro Asp Pro Ile Thr Lys Asn Lys Gln Val Leu Ser Asp Arg 
    290                 295                 300                 


Thr Phe Leu Leu Phe Gln Gln Leu Ile Gln Ser Ser Phe Val Val Glu 
305                 310                 315                 320 


Arg Gln Pro Cys Met Pro Thr His Pro Gln Arg Pro Leu Val Leu Lys 
                325                 330                 335     


Thr Gly Val Gln Phe Thr Val Lys Leu Arg Leu Leu Val Lys Leu Gln 
            340                 345                 350         


Glu Leu Asn Tyr Asn Leu Lys Val Lys Val Ser Phe Asp Lys Asp Val 
        355                 360                 365             


Asn Glu Lys Asn Thr Val Lys Gly Phe Arg Lys Phe Asn Ile Leu Gly 
    370                 375                 380                 


Thr His Thr Lys Val Met Asn Met Glu Glu Ser Thr Asn Gly Ser Leu 
385                 390                 395                 400 


Ala Ala Glu Phe Arg His Leu Gln Leu Lys Glu Gln Lys Asn Ala Gly 
                405                 410                 415     


Asn Arg Thr Asn Glu Gly Pro Leu Ile Val Thr Glu Glu Leu His Ser 
            420                 425                 430         


Leu Ser Phe Glu Thr Gln Leu Cys Gln Pro Gly Leu Val Ile Asp Leu 
        435                 440                 445             


Glu Thr Thr Ser Leu Pro Val Val Val Ile Ser Asn Val Ser Gln Leu 
    450                 455                 460                 


Pro Ser Gly Trp Ala Ser Ile Leu Trp Tyr Asn Met Leu Val Thr Glu 
465                 470                 475                 480 


Pro Arg Asn Leu Ser Phe Phe Leu Asn Pro Pro Cys Ala Trp Trp Ser 
                485                 490                 495     


Gln Leu Ser Glu Val Leu Ser Trp Gln Phe Ser Ser Val Thr Lys Arg 
            500                 505                 510         


Gly Leu Asn Ala Asp Gln Leu Ser Met Leu Gly Glu Lys Leu Leu Gly 
        515                 520                 525             


Pro Asn Ala Gly Pro Asp Gly Leu Ile Pro Trp Thr Arg Phe Cys Lys 
    530                 535                 540                 


Glu Asn Ile Asn Asp Lys Asn Phe Ser Phe Trp Pro Trp Ile Asp Thr 
545                 550                 555                 560 


Ile Leu Glu Leu Ile Lys Lys His Leu Leu Cys Leu Trp Asn Asp Gly 
                565                 570                 575     


Cys Ile Met Gly Phe Ile Ser Lys Glu Arg Glu Arg Ala Leu Leu Lys 
            580                 585                 590         


Asp Gln Gln Pro Gly Thr Phe Leu Leu Arg Phe Ser Glu Ser Ser Arg 
        595                 600                 605             


Glu Gly Ala Ile Thr Phe Thr Trp Val Glu Arg Ser Gln Asn Gly Gly 
    610                 615                 620                 


Glu Pro Asp Phe His Ala Val Glu Pro Tyr Thr Lys Lys Glu Leu Ser 
625                 630                 635                 640 


Ala Val Thr Phe Pro Asp Ile Ile Arg Asn Tyr Lys Val Met Ala Ala 
                645                 650                 655     


Glu Asn Ile Pro Glu Asn Pro Leu Lys Tyr Leu Tyr Pro Asn Ile Asp 
            660                 665                 670         


Lys Asp His Ala Phe Gly Lys Tyr Tyr Ser Arg Pro Lys Glu Ala Pro 
        675                 680                 685             


Glu Pro Met Glu Leu Asp Asp Pro Lys Arg Thr Gly Tyr Ile Lys Thr 
    690                 695                 700                 


Glu Leu Ile Ser Val Ser Glu Val His Pro Ser Arg Leu Gln Thr Thr 
705                 710                 715                 720 


Asp Asn Leu Leu Pro Met Ser Pro Glu Glu Phe Asp Glu Met Ser Arg 
                725                 730                 735     


Ile Val Gly Pro Glu Phe Asp Ser Met Met Ser Thr Val 
            740                 745                 


<210>  9
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  miR-142T single site

<400>  9
tccataaagt aggaaacact aca                                               23


<210>  10
<211>  118
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  miR-142T 4X site

<400>  10
ctagagtcga ctccataaag taggaaacac tacacgattc cataaagtag gaaacactac       60

aaccggttcc ataaagtagg aaacactaca tcactccata aagtaggaaa cactacac        118


<210>  11
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  epitope sequence

<400>  11

Ser His Leu Val Glu Ala Leu Tyr Leu Val Cys Gly Glu Arg Gly 
1               5                   10                  15  


<210>  12
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  epitope sequence

<400>  12

Leu Tyr Leu Val Cys Gly Glu Arg Gly 
1               5                   


<210>  13
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  epitope sequence

<400>  13

Ser His Leu Val Glu Ala Leu Tyr Leu Val Cys Gly Glu Glu Gly 
1               5                   10                  15  


<210>  14
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  epitope sequence

<400>  14

Trp Ser Arg Met Asp Gln Leu Ala Lys Glu Leu Thr Ala Glu 
1               5                   10                  


<210>  15
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  epitope sequence

<400>  15

Ala Val Pro Pro Leu Trp Val Arg Met Glu 
1               5                   10  


<210>  16
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  epitope sequence

<400>  16

Val Tyr Leu Lys Thr Asn Val Phe Leu 
1               5                   


<210>  17
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  epitope sequence

<400>  17

Lys Lys Gly Ala Ala Ala Leu Gly Ile Gly Thr Asp Ser Val 
1               5                   10                  


<210>  18
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tat peptide

<400>  18

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Gln 
1               5                   10          


<210>  19

<400>  19
000

<210>  20

<400>  20
000

<210>  21

<400>  21
000

<210>  22

<400>  22
000

<210>  23

<400>  23
000

<210>  24
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  codon-optimized albumin secretion signal

<400>  24
atgaagtggg taacctttct cctcctcctc ttcatctccg gttctgcctt ttctaggggc       60

aagcttatg                                                               69


<210>  25
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  albumin leader sequence

<400>  25
atgaagtggg taacctttat ttcccttctt tttctcttta gctcggctta ttccaggggt       60

gtgtttcgtc gagat                                                        75


<210>  26
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  immunoglobulin kappa-chain leader sequence

<400>  26
atggagacag acacactcct gctatgggta ctgctgctct gggttccagg ttccactggt       60

gac                                                                     63


<210>  27
<211>  675
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  endotope sequence

<400>  27
actagtgcca ccatgatgga tcaagctaga tcagcattct ctaacttgtt tggtggagaa       60

ccattgtcat atacccggtt cagcctggct cggcaagtag atggcgataa cagtcatgtg      120

gagatgaaac ttgctgtaga tgaagaagaa aatgctgaca ataacacaaa ggccaatgtc      180

acaaaaccaa aaaggtgtag tggaagtatc tgctatggga ctattgctgt gatcgtcttt      240

ttcttgattg gatttatgat tggctacttg ggctattgta aaggggtaga accaaaaact      300

gagtgtgaga gactggcagg aaccgagtct ccagtgaggg aggagccagg agaggacttc      360

cctgcaccgc ggtgtggttc ccacctggtg gaggctctct acctggtgtg tggggaggag      420

ggcttcttca agcgagcagt tcgacctcta tgggtacgta tggaaaagcg gtctctcaag      480

aagggagctg cagccttagg gattggaaca gacagtgtga ttctgattga gggcagagga      540

agtctgctaa catgcggtga cgtcgaggag aatcctggac ctgaggctct ctacctggtg      600

tgtggggagc gtggcttctt cttgagtgtg tacctgaaga ccaacgtctt cctcttcctg      660

cccgggtagg tcgac                                                       675


<210>  28
<211>  675
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  codon-optimized endotope sequence

<400>  28
actagtgcca ccatgatgga ccaagctaga tccgccttca gcaatctgtt cggaggagag       60

cccctctcct atacaagatt ctccctggcc aggcaagtgg acggcgacaa ctcccacgtc      120

gagatgaaac tcgccgtgga tgaagaggag aacgccgaca ataacaccaa ggccaacgtg      180

accaagccta agaggtgcag cggaagcatc tgctacggca caatcgccgt gatcgtcttc      240

ttcctgatcg gattcatgat cggatacctg ggctactgca agggcgtgga gcctaaaacc      300

gagtgcgaga gactcgctgg aacagagtcc cctgtcaggg aggaacctgg agaggatttc      360

cctgccccgc ggtgcggatc ccatctggtc gaagccctgt acctggtctg tggcgaggaa      420

ggattcttca agagggctgt caggcctctg tgggtgagga tggaaaagag atccctgaaa      480

aaaggcgccg ctgccctggg aattggcacc gactccgtca ttctcatcga gggcagagga      540

tccctcctga cctgtggcga cgtggaggaa aaccccggac ccgaagctct gtacctggtg      600

tgtggcgaaa ggggcttttt cctgtccgtc tacctgaaaa ccaatgtctt tctgtttctg      660

cccgggtagg tcgac                                                       675


<210>  29
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  endotope sequence

<400>  29

Met Met Asp Gln Ala Arg Ser Ala Phe Ser Asn Leu Phe Gly Gly Glu 
1               5                   10                  15      


Pro Leu Ser Tyr Thr Arg Phe Ser Leu Ala Arg Gln Val Asp Gly Asp 
            20                  25                  30          


Asn Ser His Val Glu Met Lys Leu Ala Val Asp Glu Glu Glu Asn Ala 
        35                  40                  45              


Asp Asn Asn Thr Lys Ala Asn Val Thr Lys Pro Lys Arg Cys Ser Gly 
    50                  55                  60                  


Ser Ile Cys Tyr Gly Thr Ile Ala Val Ile Val Phe Phe Leu Ile Gly 
65                  70                  75                  80  


Phe Met Ile Gly Tyr Leu Gly Tyr Cys Lys Gly Val Glu Pro Lys Thr 
                85                  90                  95      


Glu Cys Glu Arg Leu Ala Gly Thr Glu Ser Pro Val Arg Glu Glu Pro 
            100                 105                 110         


Gly Glu Asp Phe Pro Ala Pro Arg Cys Gly Ser His Leu Val Glu Ala 
        115                 120                 125             


Leu Tyr Leu Val Cys Gly Glu Glu Gly Phe Phe Lys Arg Ala Val Arg 
    130                 135                 140                 


Pro Leu Trp Val Arg Met Glu Lys Arg Ser Leu Lys Lys Gly Ala Ala 
145                 150                 155                 160 


Ala Leu Gly Ile Gly Thr Asp Ser Val Ile Leu Ile Glu Gly Arg Gly 
                165                 170                 175     


Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Glu Ala 
            180                 185                 190         


Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe Phe Leu Ser Val Tyr Leu 
        195                 200                 205             


Lys Thr Asn Val Phe Leu Phe Leu Pro Gly 
    210                 215             


<210>  30
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ins2B:9-23

<400>  30
tgtggttccc acctggtgga ggctctctac ctggtgtgtg gggagcgtgg cttcttc          57


<210>  31
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ins2B:9-23

<400>  31

Cys Gly Ser His Leu Val Glu Ala Leu Tyr Leu Val Cys Gly Glu Arg 
1               5                   10                  15      


Gly Phe Phe 
            


<210>  32
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ins2B:9-23 R22E

<400>  32
tgtggttccc acctggtgga ggctctctac ctggtgtgtg gggaggaggg cttcttc          57


<210>  33
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ins2B:9-23 R22E

<400>  33

Cys Gly Ser His Leu Val Glu Ala Leu Tyr Leu Val Cys Gly Glu Glu 
1               5                   10                  15      


Gly Phe Phe 
            


<210>  34
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ins2B:9-23 E21G/R22E

<400>  34
tgtggttccc acctggtgga ggctctctac ctggtgtgtg ggggagaggg cttcttc          57


<210>  35
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ins2B:9-23 E21G/R22E

<400>  35

Cys Gly Ser His Leu Val Glu Ala Leu Tyr Leu Val Cys Gly Gly Glu 
1               5                   10                  15      


Gly Phe Phe 
            


<210>  36
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ChgA WE14

<400>  36
aagcgatgga gcaggatgga ccagctggcc aaagagctga cagcagagaa gcgg             54


<210>  37
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ChgA WE14

<400>  37

Lys Arg Trp Ser Arg Met Asp Gln Leu Ala Lys Glu Leu Thr Ala Glu 
1               5                   10                  15      


Lys Arg 
        


<210>  38
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ChgA 1040-79

<400>  38
aagcgagcag ttcgacctct atgggtacgt atggaaaagc gg                          42


<210>  39
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ChgA 1040-79

<400>  39

Lys Arg Ala Val Arg Pro Leu Trp Val Arg Met Glu Lys Arg 
1               5                   10                  


<210>  40
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GAD65

<400>  40
tctctcaaga agggagctgc agccttaggg attggaacag acagtgtgat tctgatt          57


<210>  41
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GAD65

<400>  41

Ser Leu Lys Lys Gly Ala Ala Ala Leu Gly Ile Gly Thr Asp Ser Val 
1               5                   10                  15      


Ile Leu Ile 
            


<210>  42
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GAD65-524-543

<400>  42
agaatgagcc gcctctcaaa ggtggcgcca gtgattaaag ccagaatgat ggagtatggg       60

accacaatgg tc                                                           72


<210>  43
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GAD65-524-543

<400>  43

Arg Met Ser Arg Leu Ser Lys Val Ala Pro Val Ile Lys Ala Arg Met 
1               5                   10                  15      


Met Glu Tyr Gly Thr Thr Met Val 
            20                  


<210>  44
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  P2A (from porcine teschovirus-1)

<400>  44
gctactaact tcagcctgct gaagcaggct ggagacgtgg aggagaaccc tggacct          57


<210>  45
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P2A (from porcine teschovirus-1)

<400>  45

Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  46
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  T2A (from Thosea asigna virus)

<400>  46
gagggcagag gaagtctgct aacatgcggt gacgtcgagg agaatcctgg acct             54


<210>  47
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T2A (from Thosea asigna virus)

<400>  47

Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210>  48
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  E2A (from equine rhinitis A virus)

<400>  48
cagtgtacta attatgctct cttgaaattg gctggagatg ttgagagcaa ccctggacct       60


<210>  49
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E2A (from equine rhinitis A virus)

<400>  49

Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp Val Glu Ser 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  50
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  F2A (from Foot-and-mouth disease virus)

<400>  50
gtgaaacaga ctttgaattt tgaccttctc aagttggcgg gagacgtgga gtccaaccct       60

ggacct                                                                  66


<210>  51
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F2A (from Foot-and-mouth disease virus)

<400>  51

Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val 
1               5                   10                  15      


Glu Ser Asn Pro Gly Pro 
            20          


<210>  52
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ins2B:15-23

<400>  52
gaggctctct acctggtgtg tggggagcgt ggcttcttc                              39


<210>  53
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ins2B:15-23

<400>  53

Glu Ala Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe Phe 
1               5                   10              


<210>  54
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IGRP-206-214

<400>  54
ttgagtgtgt acctgaagac caacgtcttc ctcttcctg                              39


<210>  55
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGRP-206-214

<400>  55

Leu Ser Val Tyr Leu Lys Thr Asn Val Phe Leu Phe Leu 
1               5                   10              


<210>  56
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GAD65-206-214

<400>  56

Thr Tyr Glu Ile Ala Pro Val Phe Val 
1               5                   


<210>  57
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GAD65-546-554

<400>  57

Ser Tyr Gln Pro Leu Gly Asp Lys Val 
1               5                   


<210>  58
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hybrid insulin peptide

<400>  58

Gly Asp Leu Gln Thr Leu Trp Ser Arg Met Asp 
1               5                   10      


<210>  59
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hybrid insulin peptide

<400>  59

Leu Gln Thr Leu Ala Leu Trp Ser Arg Met Asp 
1               5                   10      


<210>  60
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hybrid insulin peptide

<400>  60

Leu Gln Thr Leu Ala Leu Asn Ala Ala Arg Asp 
1               5                   10      


<210>  61
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hybrid insulin peptide

<400>  61

Gly Gln Val Glu Leu Gly Gly Gly Ser Ser Pro Glu Thr Leu Ile 
1               5                   10                  15  


<210>  62
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hybrid insulin peptide

<400>  62

Gly Gln Val Glu Leu Gly Gly Gly Asn Ala Val Glu Val Leu Lys 
1               5                   10                  15  


