﻿                         序列表

<110>  深圳市瑞吉生物科技有限公司

<120>  一种mRNA剂型的骨关节炎药物制剂及其制备方法和应用

<141>  2021-03-24

<160>  6

<170>  SIPOSequenceListing 1.0

<210>  1
<211>  1236
<212>  RNA
<213>  Artificial Sequence

<400>  1
augaagaugc acuugcaaag ggcucuggug guccuggccc ugcugaacuu ugccacgguc        60
agccucucuc uguccacuug caccaccuug gacuucggcc acaucaagaa gaagagggug       120
gaagccauua ggggacagau cuugagcaag cucaggcuca ccagcccccc ugagccaacg       180
gugaugaccc acguccccua ucagguccug gcccuuuaca acagcacccg ggagcugcug       240
gaggagaugc auggggagag ggaggaaggc ugcacccagg aaaacaccga gucggaauac       300
uaugccaaag aaauccauaa auucgacaug auccaggggc uggcggagca caacgaacug       360
gcugucugcc cuaaaggaau uaccuccaag guuuuccgcu ucaauguguc cucaguggag       420
aaaaauagaa ccaaccuauu ccgagcagaa uuccgggucu ugcgggugcc caaccccagc       480
ucuaagcgga augagcagag gaucgagcuc uuccagaucc uucggccaga ugagcacauu       540
gccaaacagc gcuauaucgg uggcaagaau cugcccacac ggggcacugc cgaguggcug       600
uccuuugaug ucacugacac ugugcgugag uggcuguuga gaagagaguc caacuuaggu       660
cuagaaauca gcauucacug uccaugucac accuuucagc ccaauggaga uauccuggaa       720
aacauucacg aggugaugga aaucaaauuc aaaggcgugg acaaugagga ugaccauggc       780
cguggagauc uggggcgccu caagaagcag aaggaucacc acaacccuca ucuaauccuc       840
augaugauuc ccccacaccg gcucgacaac ccgggccagg ggggucagag gaagaagcgg       900
gcuuuggaca ccaauuacug cuuccgcaac uuggaggaga acugcugugu gcgcccccuc       960
uacauugacu uccgacagga ucugggcugg aagugggucc augaaccuaa gggcuacuau      1020
gccaacuucu gcucaggccc uugcccauac cuccgcagug cagacacaac ccacagcacg      1080
gugcugggac uguacaacac ucugaacccu gaagcaucug ccucgccuug cugcgugccc      1140
caggaccugg agccccugac cauccuguac uauguuggga ggacccccaa aguggagcag      1200
cucuccaaca ugguggugaa gucuuguaaa uguagc                                1236

<210>  2
<211>  336
<212>  RNA
<213>  Artificial Sequence

<400>  2
gcgcuggaua ccaacuauug cuuucgcaac cuggaagaaa acugcugcgu gcgcccgcug        60
uauauugauu uucgccagga ucugggcugg aaaugggugc augaaccgaa aggcuauuau       120
gcgaacuuuu gcagcggccc gugcccguau cugcgcagcg cggauaccac ccauagcacc       180
gugcugggcc uguauaacac ccugaacccg gaagcgagcg cgagcccgug cugcgugccg       240
caggaucugg aaccgcugac cauucuguau uaugugggcc gcaccccgaa aguggaacag       300
cugagcaaca ugguggugaa aagcugcaaa ugcagc                                 336

<210>  3
<211>  1998
<212>  RNA
<213>  Artificial Sequence

<400>  3
gggaggcggc gaugcgcacg gccggagaga cgcggaggag gagacaugag ccggcgggcg        60
cccagacgga gcggccguga cgcuuucgcg cugcagccgc gcgccccgac cccggagcgc       120
ugaccccugg ccccacgcag cuccgcgccc gggccggaga gcgcaacucg gcuuccagac       180
ccgccgcgca ugcugucccc ggacugagcc gggcagccag ccucccacgg acgcccggac       240
ggccggccgg ccagcaguga gcgagcuucc ccgcaccggc caggcgccuc cugcacagcg       300
gcugccgccc cgcagccccu gcgccagccc ggagggcgca gcgcucggga ggagccgcgc       360
ggggcgcuga ugccgcaggg cgcgccgcgg agcgccccgg agcagcagag ucugcagcag       420
cagcagccgg cgaggaggga gcagcagcag cggcggcggc ggcggcggcg gcggcggagg       480
cgcccggucc cggccgcgcg gagcggacau gugcaggcug ggcuaggagc cgccgccucc       540
cucccgccca gcgauguauu cagcgcccuc cgccugcacu ugccuguguu uacacuuccu       600
gcugcugugc uuccagguac aggugcuggu ugccgaggag aacguggacu uccgcaucca       660
cguggagaac cagacgcggg cucgggacga ugugagccgu aagcagcugc ggcuguacca       720
gcucuacagc cggaccagug ggaaacacau ccagguccug ggccgcagga ucagugcccg       780
cggcgaggau ggggacaagu augcccagcu ccuaguggag acagacaccu ucgguaguca       840
aguccggauc aagggcaagg agacggaauu cuaccugugc augaaccgca aaggcaagcu       900
cguggggaag cccgauggca ccagcaagga guguguguuc aucgagaagg uucuggagaa       960
caacuacacg gcccugaugu cggcuaagua cuccggcugg uacgugggcu ucaccaagaa      1020
ggggcggccg cggaagggcc ccaagacccg ggagaaccag caggacgugc auuucaugaa      1080
gcgcuacccc aaggggcagc cggagcuuca gaagcccuuc aaguacacga cggugaccaa      1140
gaggucccgu cggauccggc ccacacaccc ugccuaggcc accccgccgc ggccccucag      1200
gucgcccugg ccacacucac acucccagaa aacugcauca gaggaauauu uuuacaugaa      1260
aaauaaggaa gaagcucuau uuuuguacau uguguuuaaa agaagacaaa aacugaacca      1320
aaacucuugg ggggaggggu gauaaggauu uuauuguuga cuugaaaccc ccgaugacaa      1380
aagacucacg caaagggacu guagucaacc cacaggugcu ugucucucuc uaggaacaga      1440
caacucuaaa cucgucccca gaggaggacu ugaaugagga aaccaacacu uugagaaacc      1500
aaaguccuuu uucccaaagg uucugaaagg aaaaaaaaaa aaaacaaaaa aaaagaaaaa      1560
caaagagaaa guaguacucc gcccaccaac aaacuccccc uaacuuuccc aauccucugu      1620
uccugcccca aacuccaaca aaaaucgcuc ucugguuugc agucauuuau uuauuguccg      1680
cugcaagcug ccccgagaca ccgcgcaggg aaggcgugcc ccugggaauu cuccgcgccu      1740
cgaccucccg acgacagacg ccucguccaa ucauggugac ccugccuugc ucgcaguucu      1800
ggaggaugcu gcuaucgacc uuccgugacu cacgugaccu aguacaccaa ugauaaggga      1860
auauuuuaaa accagcuaua uuauauauau uauauauaua uaagcuauuu auuucaccuc      1920
ucuguauauu gcaguuucau gaaccaagua uuacugccuc aacaauuaaa aacaacagac      1980
aaauuauuua aaaaacca                                                    1998

<210>  4
<211>  624
<212>  RNA
<213>  Artificial Sequence

<400>  4
auguauucag cgcccuccgc cugcacuugc cuguguuuac acuuccugcu gcugugcuuc        60
cagguacagg ugcugguugc cgaggagaac guggacuucc gcauccacgu ggagaaccag       120
acgcgggcuc gggacgaugu gagccguaag cagcugcggc uguaccagcu cuacagccgg       180
accaguggga aacacaucca gguccugggc cgcaggauca gugcccgcgg cgaggauggg       240
gacaaguaug cccagcuccu aguggagaca gacaccuucg guagucaagu ccggaucaag       300
ggcaaggaga cggaauucua ccugugcaug aaccgcaaag gcaagcucgu ggggaagccc       360
gauggcacca gcaaggagug uguguucauc gagaagguuc uggagaacaa cuacacggcc       420
cugaugucgg cuaaguacuc cggcugguac gugggcuuca ccaagaaggg gcggccgcgg       480
aagggcccca agacccggga gaaccagcag gacgugcauu ucaugaagcg cuaccccaag       540
gggcagccgg agcuucagaa gcccuucaag uacacgacgg ugaccaagag gucccgucgg       600
auccggccca cacacccugc cuag                                              624

<210>  5
<211>  20
<212>  DNA
<213>  Artificial Sequence

<400>  5
ctctagagga tcgaaccctt                                                    20

<210>  6
<211>  20
<212>  DNA
<213>  Artificial Sequence

<400>  6
aaacccgctg atcagcctcg                                                    20

