                         SEQUENCE LISTING

<110>  ԴҽҩƼϺ޹˾
 
<120>  CD3弰;

<130>  202105

<160>  119   

<170>  PatentIn version 3.5

<210>  1
<211>  119
<212>  PRT
<213>  AP191ɱ

<400>  1

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Met Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asp Gly Ser Thr Lys Phe Asn Glu Lys Phe 
    50                  55                  60                  


Arg Gly Lys Thr Ser Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Phe Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Ile Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Ser Leu Tyr Tyr Phe Glu Phe Trp Gly His Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  2
<211>  112
<212>  PRT
<213>  AP191ɱ

<400>  2

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 
1               5                   10                  15      


Glu Thr Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Thr Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Asp Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Val Gln 
                85                  90                  95      


Ser Tyr Thr Leu Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  3
<211>  125
<212>  PRT
<213>  AP591ɱ

<400>  3

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Arg Ser Lys Ile Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Arg Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Ser Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Asp Asn Phe Tyr Gly Ser Thr Tyr Ser Trp Phe 
            100                 105                 110         


Ala Asp Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120                 125 


<210>  4
<211>  108
<212>  PRT
<213>  AP591ɱ

<400>  4

Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu Thr 
1               5                   10                  15      


Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Val Val Thr Thr Ser Asn 
            20                  25                  30          


Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly Leu 
        35                  40                  45              


Ile Gly Ala Thr Asn Tyr Arg Val Pro Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala Gln 
65                  70                  75                  80  


Thr Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp Tyr Ser Asn His 
                85                  90                  95      


Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  5
<211>  117
<212>  PRT
<213>  AP831ɱ

<400>  5

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Asn 
            20                  25                  30          


Tyr Ile His Trp Val Lys Glu Lys Pro Gly Glu Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asp Gly Thr Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Thr Thr Leu Ala Ser Asp Lys Ser Ser Asn Thr Val Tyr 
65                  70                  75                  80  


Met Phe Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Ile Tyr Phe Cys 
                85                  90                  95      


Thr Arg Asn Asn Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser 
        115         


<210>  6
<211>  112
<212>  PRT
<213>  AP831ɱ

<400>  6

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Asn Cys Lys Ser Ser Gln Ser Leu Phe Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Leu Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Phe Ile Leu Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  7
<211>  5
<212>  PRT
<213>  Kabat AP191 CDR-H1

<400>  7

Ser Tyr Tyr Ile His 
1               5   


<210>  8
<211>  17
<212>  PRT
<213>  Kabat AP191 CDR-H2

<400>  8

Trp Ile Tyr Pro Gly Asp Gly Ser Thr Lys Phe Asn Glu Lys Phe Arg 
1               5                   10                  15      


Gly 
    


<210>  9
<211>  10
<212>  PRT
<213>  Kabat AP191 CDR-H3

<400>  9

Asp Gly Tyr Ser Leu Tyr Tyr Phe Glu Phe 
1               5                   10  


<210>  10
<211>  17
<212>  PRT
<213>  Kabat AP191 CDR-L1

<400>  10

Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Thr Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  11
<211>  7
<212>  PRT
<213>  Kabat AP191 CDR-L2

<400>  11

Trp Ala Ser Thr Arg Asp Ser 
1               5           


<210>  12
<211>  8
<212>  PRT
<213>  Kabat/IMGT AP191 CDR-L3

<400>  12

Val Gln Ser Tyr Thr Leu Arg Thr 
1               5               


<210>  13
<211>  8
<212>  PRT
<213>  IMGT AP191 CDR-H1

<400>  13

Gly Tyr Thr Phe Thr Ser Tyr Tyr 
1               5               


<210>  14
<211>  8
<212>  PRT
<213>  IMGT AP191 CDR-H2

<400>  14

Ile Tyr Pro Gly Asp Gly Ser Thr 
1               5               


<210>  15
<211>  12
<212>  PRT
<213>  IMGT AP191 CDR-H3

<400>  15

Ala Arg Asp Gly Tyr Ser Leu Tyr Tyr Phe Glu Phe 
1               5                   10          


<210>  16
<211>  12
<212>  PRT
<213>  IMGT AP191 CDR-L1

<400>  16

Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Thr Tyr 
1               5                   10          


<210>  17
<211>  3
<212>  PRT
<213>  IMGT AP191 CDR-L2

<400>  17

Trp Ala Ser 
1           


<210>  18
<211>  5
<212>  PRT
<213>  Kabat AP591 CDR-H1

<400>  18

Thr Tyr Ala Met Asn 
1               5   


<210>  19
<211>  19
<212>  PRT
<213>  Kabat AP591 CDR-H2

<400>  19

Arg Ile Arg Ser Lys Ile Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Arg Asp 
            


<210>  20
<211>  14
<212>  PRT
<213>  Kabat AP591 CDR-H3

<400>  20

His Asp Asn Phe Tyr Gly Ser Thr Tyr Ser Trp Phe Ala Asp 
1               5                   10                  


<210>  21
<211>  14
<212>  PRT
<213>  Kabat AP591 CDR-L1

<400>  21

Arg Ser Ser Thr Gly Val Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210>  22
<211>  7
<212>  PRT
<213>  Kabat AP591 CDR-L2

<400>  22

Ala Thr Asn Tyr Arg Val Pro 
1               5           


<210>  23
<211>  9
<212>  PRT
<213>  Kabat/IMGT AP591 CDR-L3

<400>  23

Val Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210>  24
<211>  8
<212>  PRT
<213>  IMGT AP591 CDR-H1

<400>  24

Gly Phe Thr Phe Asn Thr Tyr Ala 
1               5               


<210>  25
<211>  10
<212>  PRT
<213>  IMGT AP591 CDR-H2

<400>  25

Ile Arg Ser Lys Ile Asn Asn Tyr Ala Thr 
1               5                   10  


<210>  26
<211>  16
<212>  PRT
<213>  IMGT AP591 CDR-H3

<400>  26

Val Arg His Asp Asn Phe Tyr Gly Ser Thr Tyr Ser Trp Phe Ala Asp 
1               5                   10                  15      


<210>  27
<211>  9
<212>  PRT
<213>  IMGT AP591 CDR-L1

<400>  27

Thr Gly Val Val Thr Thr Ser Asn Tyr 
1               5                   


<210>  28
<211>  3
<212>  PRT
<213>  IMGT AP591 CDR-L2

<400>  28

Ala Thr Asn 
1           


<210>  29
<211>  5
<212>  PRT
<213>  Kabat AP831 CDR-H1

<400>  29

Asn Asn Tyr Ile His 
1               5   


<210>  30
<211>  17
<212>  PRT
<213>  Kabat AP831 CDR-H2

<400>  30

Trp Ile Tyr Pro Gly Asp Gly Thr Thr Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  31
<211>  8
<212>  PRT
<213>  Kabat AP831 CDR-H3

<400>  31

Asn Asn Asn Tyr Tyr Phe Asp Tyr 
1               5               


<210>  32
<211>  17
<212>  PRT
<213>  Kabat AP831 CDR-L1

<400>  32

Lys Ser Ser Gln Ser Leu Phe Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  33
<211>  7
<212>  PRT
<213>  Kabat AP831 CDR-L2

<400>  33

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  34
<211>  8
<212>  PRT
<213>  Kabat/IMGT AP831 CDR-L3

<400>  34

Lys Gln Ser Phe Ile Leu Arg Thr 
1               5               


<210>  35
<211>  8
<212>  PRT
<213>  IMGT AP831 CDR-H1

<400>  35

Gly Tyr Thr Phe Thr Asn Asn Tyr 
1               5               


<210>  36
<211>  8
<212>  PRT
<213>  IMGT AP831 CDR-H2

<400>  36

Ile Tyr Pro Gly Asp Gly Thr Thr 
1               5               


<210>  37
<211>  10
<212>  PRT
<213>  IMGT AP831 CDR-H3

<400>  37

Thr Arg Asn Asn Asn Tyr Tyr Phe Asp Tyr 
1               5                   10  


<210>  38
<211>  12
<212>  PRT
<213>  IMGT AP831 CDR-L1

<400>  38

Gln Ser Leu Phe Asn Ser Arg Thr Arg Lys Asn Tyr 
1               5                   10          


<210>  39
<211>  3
<212>  PRT
<213>  IMGT AP831 CDR-L2

<400>  39

Trp Ala Ser 
1           


<210>  40
<211>  117
<212>  PRT
<213>  AB610ɱ

<400>  40

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asn Asn 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asp Gly Thr Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Thr Thr Leu Ala Ser Asp Asp Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Thr Arg Asn Asn Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  41
<211>  111
<212>  PRT
<213>  AB610ɱ

<400>  41

Glu Ile Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Gln Ser Leu Phe Asn Ser Arg 
            20                  25                  30          


Thr Arg Lys Asn Tyr Leu Ala Trp Val Gln Glu Lys Pro Gly Gln Ala 
        35                  40                  45              


Pro Arg Gly Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Thr Pro 
    50                  55                  60                  


Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu 
65                  70                  75                  80  


Ser Gly Val Gln Pro Glu Asp Glu Ala Ile Tyr Tyr Cys Lys Gln Ser 
                85                  90                  95      


Phe Ile Leu Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  42
<211>  117
<212>  PRT
<213>  AB611ɱ

<400>  42

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Asn 
            20                  25                  30          


Tyr Ile His Trp Val Lys Glu Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asp Gly Thr Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Thr Thr Leu Ala Ser Asp Lys Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Ile Tyr Phe Cys 
                85                  90                  95      


Thr Arg Asn Asn Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  43
<211>  112
<212>  PRT
<213>  AB611ɱ

<400>  43

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Met Asn Cys Lys Ser Ser Gln Ser Leu Phe Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Glu 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Phe Ile Leu Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  44
<211>  119
<212>  PRT
<213>  AB612ɱ

<400>  44

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Glu Gly Ser Thr Lys Phe Asn Glu Lys Phe 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Ala Arg Glu Gly Tyr Ser Leu Tyr Tyr Phe Glu Phe Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  45
<211>  111
<212>  PRT
<213>  AB612ɱ

<400>  45

Glu Ile Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Gln Ser Leu Leu Asn Ser Arg 
            20                  25                  30          


Thr Arg Lys Thr Tyr Leu Ala Trp Val Gln Glu Lys Pro Asp His Leu 
        35                  40                  45              


Phe Thr Gly Leu Ile Tyr Trp Ala Ser Thr Arg Asp Pro Gly Thr Pro 
    50                  55                  60                  


Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu 
65                  70                  75                  80  


Ser Gly Val Gln Pro Glu Asp Glu Ala Ile Tyr Tyr Cys Val Gln Ser 
                85                  90                  95      


Tyr Thr Leu Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  46
<211>  119
<212>  PRT
<213>  AB613ɱ

<400>  46

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Glu Gly Ser Thr Lys Phe Asn Glu Lys Phe 
    50                  55                  60                  


Arg Gly Arg Thr Thr Leu Thr Ala Asp Lys Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Glu Gly Tyr Ser Leu Tyr Tyr Phe Glu Phe Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  47
<211>  112
<212>  PRT
<213>  AB613ɱ

<400>  47

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Thr Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Glu 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Asp Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Val Gln 
                85                  90                  95      


Ser Tyr Thr Leu Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  48
<211>  125
<212>  PRT
<213>  AB614ɱ

<400>  48

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Arg Ser Lys Ile Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Asp Asn Phe Tyr Gly Ser Thr Tyr Ser Trp Phe 
            100                 105                 110         


Ala Asp Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  49
<211>  109
<212>  PRT
<213>  AB614ɱ

<400>  49

Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Val Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Ala Thr Asn Tyr Arg Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  50
<211>  17
<212>  PRT
<213>  Kabat AB610 CDR-L1

<400>  50

Arg Ser Ser Gln Ser Leu Phe Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  51
<211>  17
<212>  PRT
<213>  Kabat AB612 CDR-H2

<400>  51

Trp Ile Tyr Pro Gly Glu Gly Ser Thr Lys Phe Asn Glu Lys Phe Arg 
1               5                   10                  15      


Gly 
    


<210>  52
<211>  10
<212>  PRT
<213>  Kabat AB612 CDR-H3

<400>  52

Glu Gly Tyr Ser Leu Tyr Tyr Phe Glu Phe 
1               5                   10  


<210>  53
<211>  17
<212>  PRT
<213>  Kabat AB612 CDR-L1

<400>  53

Arg Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Thr Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  54
<211>  7
<212>  PRT
<213>  Kabat AB612 CDR-L2

<400>  54

Trp Ala Ser Thr Arg Asp Pro 
1               5           


<210>  55
<211>  8
<212>  PRT
<213>  IMGT AB612 CDR-H2

<400>  55

Ile Tyr Pro Gly Glu Gly Ser Thr 
1               5               


<210>  56
<211>  12
<212>  PRT
<213>  IMGT AB612 CDR-H3

<400>  56

Ala Arg Glu Gly Tyr Ser Leu Tyr Tyr Phe Glu Phe 
1               5                   10          


<210>  57
<211>  19
<212>  PRT
<213>  Kabat AB614 CDR-H2

<400>  57

Arg Ile Arg Ser Lys Ile Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210>  58
<211>  7
<212>  PRT
<213>  Kabat AB614 CDR-L2

<400>  58

Ala Thr Asn Tyr Arg Ala Pro 
1               5           


<210>  59
<211>  107
<212>  PRT
<213>  ˦ʺ㶨

<400>  59

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  60
<211>  330
<212>  PRT
<213>  IgG1ҰͰ

<400>  60

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  61
<211>  330
<212>  PRT
<213>  IgG1(N297A)ͻ㶨

<400>  61

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  62
<211>  330
<212>  PRT
<213>  IgG1(L234A,L235A)ͻ㶨

<400>  62

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  63
<211>  327
<212>  PRT
<213>  IgG4ҰͰ

<400>  63

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  64
<211>  327
<212>  PRT
<213>  IgG4(S228P)ͻ㶨

<400>  64

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  65
<211>  444
<212>  PRT
<213>  AB610

<400>  65

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asn Asn 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asp Gly Thr Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Thr Thr Leu Ala Ser Asp Asp Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Thr Arg Asn Asn Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro 
    210                 215                 220                 


Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln 
            340                 345                 350         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 


<210>  66
<211>  218
<212>  PRT
<213>  AB610

<400>  66

Glu Ile Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Gln Ser Leu Phe Asn Ser Arg 
            20                  25                  30          


Thr Arg Lys Asn Tyr Leu Ala Trp Val Gln Glu Lys Pro Gly Gln Ala 
        35                  40                  45              


Pro Arg Gly Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Thr Pro 
    50                  55                  60                  


Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu 
65                  70                  75                  80  


Ser Gly Val Gln Pro Glu Asp Glu Ala Ile Tyr Tyr Cys Lys Gln Ser 
                85                  90                  95      


Phe Ile Leu Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  67
<211>  1332
<212>  DNA
<213>  AB610

<400>  67
gaggtgcagc tgctggagtc tggaggagga ctggtgcagc ctggaggaag cctgaagctg       60

tcttgcgccg cttccggcta caccttcaca aacaattata tccattgggt gaggcaggct      120

ccaggcaagg gactggagtg gatcggctgg atctaccctg gcgatggcac cacaaagtat      180

aacgagaagt ttaagggcaa gaccacactg gcctctgacg attccaagaa taccgcttac      240

ctgcagatga acaatctgaa gaccgaggat acagctatgt acttctgcac ccggaacaat      300

aactactatt ttgactattg gggccagggc accctggtga cagtgtccag cgcctctacc      360

aagggccctt ccgtgttccc tctggcccca tgttcccgca gcacctctga gtccacagcc      420

gctctgggct gcctggtgaa ggactatttc cccgagcctg tgaccgtgtc ctggaacagc      480

ggcgctctga cctccggagt gcacacattt cccgccgtgc tgcagtcttc cggcctgtac      540

agcctgagct ctgtggtgac cgtgccatcc agctctctgg gcaccaagac atatacctgt      600

aacgtggatc ataagccctc caatacaaag gtggacaagc gcgtggagag caagtacgga      660

ccaccatgtc ctccatgccc agctcccgag tttctgggcg gccctagcgt gttcctgttt      720

ccccctaagc caaaggatac cctgatgatc agcaggaccc ctgaggtgac atgcgtggtg      780

gtggacgtgt cccaggagga cccagaggtg cagttcaact ggtacgtgga cggcgtggag      840

gtgcacaatg ccaagaccaa gcctcgggag gagcagttta attccaccta cagagtggtg      900

agcgtgctga cagtgctgca tcaggactgg ctgaacggca aggagtataa gtgtaaggtg      960

tccaataagg gcctgccatc cagcatcgag aagaccatca gcaaggctaa gggccagccc     1020

agggagcctc aggtgtacac actgccaccc tctcaggagg agatgaccaa gaaccaggtg     1080

tccctgacat gcctggtgaa gggcttctat ccttccgata tcgccgtgga gtgggagagc     1140

aatggccagc cagagaacaa ttacaagacc acacctccag tgctggattc tgacggctcc     1200

ttctttctgt attcccggct gaccgtggac aagagcagat ggcaggaggg caacgtgttt     1260

agctgttctg tgatgcatga ggctctgcac aatcattaca cacagaagtc cctgagcctg     1320

tctctgggca ag                                                         1332


<210>  68
<211>  654
<212>  DNA
<213>  AB610

<400>  68
gagatcgtgg tgacccagga gccaagcctg acagtgtctc ccggcggcac cgtgacactg       60

acctgtagat cttcccagtc cctgttcaac agcaggaccc ggaagaatta cctggcctgg      120

gtgcaggaga agccaggaca ggctccaagg ggactgatct attgggcttc taccagggag      180

tccggcacac cagctcggtt tagcggatct ctgctgggag gcaaggctgc cctgaccctg      240

tccggagtgc agcccgagga cgaggctatc tactattgca agcagagctt catcctgagg      300

acctttggcg gcggcacaaa gctggagatc aagaggaccg tggctgcccc ctccgtgttc      360

atctttcccc cttccgatga gcagctgaag tccggcacag ccagcgtggt gtgcctgctg      420

aacaatttct accctagaga ggctaaggtg cagtggaagg tggacaacgc cctgcagagc      480

ggcaattctc aggagtccgt gaccgagcag gatagcaagg actctacata ttccctgtcc      540

agcacactga ccctgagcaa ggctgattac gagaagcaca aggtgtatgc ctgtgaggtg      600

acccatcagg gcctgtcttc ccctgtgaca aagtctttca accggggcga gtgc            654


<210>  69
<211>  444
<212>  PRT
<213>  AB611

<400>  69

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Asn 
            20                  25                  30          


Tyr Ile His Trp Val Lys Glu Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asp Gly Thr Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Thr Thr Leu Ala Ser Asp Lys Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Ile Tyr Phe Cys 
                85                  90                  95      


Thr Arg Asn Asn Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro 
    210                 215                 220                 


Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln 
            340                 345                 350         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 


<210>  70
<211>  219
<212>  PRT
<213>  AB611

<400>  70

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Met Asn Cys Lys Ser Ser Gln Ser Leu Phe Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Glu 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Phe Ile Leu Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  71
<211>  1332
<212>  DNA
<213>  AB611

<400>  71
gaggtgcagc tggtgcagag cggagctgag gtgaagaagc caggcagctc tgtgaaggtg       60

agctgtaagg cttctggcta cacattcacc aataactata tccactgggt gaaagaaaag      120

ccaggacagg gcctggaatg gatcggatgg atctaccccg gcgatggtac taccaaatac      180

aatgaaaagt ttaagggcaa gaccacactg gcgagcgaca agtctacaaa taccgcttac      240

atggagctgt ccagcctgag gtctgaggat accgccatct acttctgcac acggaacaac      300

aactactact tcgactactg gggccagggc accacagtga ccgtgtcttc cgcctctacc      360

aagggccctt ccgtgttccc tctggcccca tgttcccgca gcacctctga gtccacagcc      420

gctctgggct gcctggtgaa ggactatttc cccgagcctg tgaccgtgtc ctggaacagc      480

ggcgctctga cctccggagt gcacacattt cccgccgtgc tgcagtcttc cggcctgtac      540

agcctgagct ctgtggtgac cgtgccatcc agctctctgg gcaccaagac atatacctgt      600

aacgtggatc ataagccctc caatacaaag gtggacaagc gcgtggagag caagtacgga      660

ccaccatgtc ctccatgccc agctcccgag tttctgggcg gccctagcgt gttcctgttt      720

ccccctaagc caaaggatac cctgatgatc agcaggaccc ctgaggtgac atgcgtggtg      780

gtggacgtgt cccaggagga cccagaggtg cagttcaact ggtacgtgga cggcgtggag      840

gtgcacaatg ccaagaccaa gcctcgggag gagcagttta attccaccta cagagtggtg      900

agcgtgctga cagtgctgca tcaggactgg ctgaacggca aggagtataa gtgtaaggtg      960

tccaataagg gcctgccatc cagcatcgag aagaccatca gcaaggctaa gggccagccc     1020

agggagcctc aggtgtacac actgccaccc tctcaggagg agatgaccaa gaaccaggtg     1080

tccctgacat gcctggtgaa gggcttctat ccttccgata tcgccgtgga gtgggagagc     1140

aatggccagc cagagaacaa ttacaagacc acacctccag tgctggattc tgacggctcc     1200

ttctttctgt attcccggct gaccgtggac aagagcagat ggcaggaggg caacgtgttt     1260

agctgttctg tgatgcatga ggctctgcac aatcattaca cacagaagtc cctgagcctg     1320

tctctgggca ag                                                         1332


<210>  72
<211>  657
<212>  DNA
<213>  AB611

<400>  72
gatatcgtga tgacacagtc cccagacagc ctggccgtga gcctgggaga gcgggctacc       60

atgaactgta agagctctca gtctctgttc aactctagaa cacgcaaaaa ctacctggcc      120

tggtatcagc agaagcctgg cgagtctcca aagctgctga tctactgggc ttctaccaga      180

gagtccggag tgcctgatcg cttctccgga agcggctctg gcacagactt tacactgacc      240

atctccagcc tgcaggccga ggatgtggcc gtgtactact gtaaacaaag cttcatcctg      300

aggacctttg gcggaggcac aaaggtggag atcaagagga ccgtggctgc cccctccgtg      360

ttcatctttc ccccttccga tgagcagctg aagtccggca cagccagcgt ggtgtgcctg      420

ctgaacaatt tctaccctag agaggctaag gtgcagtgga aggtggacaa cgccctgcag      480

agcggcaatt ctcaggagtc cgtgaccgag caggatagca aggactctac atattccctg      540

tccagcacac tgaccctgag caaggctgat tacgagaagc acaaggtgta tgcctgtgag      600

gtgacccatc agggcctgtc ttcccctgtg acaaagtctt tcaaccgggg cgagtgc         657


<210>  73
<211>  446
<212>  PRT
<213>  AB612

<400>  73

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Glu Gly Ser Thr Lys Phe Asn Glu Lys Phe 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Ala Arg Glu Gly Tyr Ser Leu Tyr Tyr Phe Glu Phe Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
            260                 265                 270         


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445     


<210>  74
<211>  218
<212>  PRT
<213>  AB612

<400>  74

Glu Ile Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Gln Ser Leu Leu Asn Ser Arg 
            20                  25                  30          


Thr Arg Lys Thr Tyr Leu Ala Trp Val Gln Glu Lys Pro Asp His Leu 
        35                  40                  45              


Phe Thr Gly Leu Ile Tyr Trp Ala Ser Thr Arg Asp Pro Gly Thr Pro 
    50                  55                  60                  


Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu 
65                  70                  75                  80  


Ser Gly Val Gln Pro Glu Asp Glu Ala Ile Tyr Tyr Cys Val Gln Ser 
                85                  90                  95      


Tyr Thr Leu Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  75
<211>  1338
<212>  DNA
<213>  AB612

<400>  75
gaagtccagc tgctggagag cggcggcgga ctggtgcagc caggcggcag cctgaagctg       60

tcttgtgccg cttccggcta cacattcacc tcttactata tccattgggt gcggcaggct      120

cctggcaagg gcctggaatg ggtgggctgg atctatccag gcgagggctc caccaagttt      180

aacgagaagt tcaggggccg gtttaccatc agcagggacg attctaagaa tacagcctac      240

ctgcagatga ataatctgaa gaccgaggac acagccatgt acttttgcgc tcgggagggc      300

tatagcctgt actattttga gttctggggt cagggcaccc tggtcacagt gtcttccgcc      360

tctaccaagg gcccttccgt gttccctctg gccccatgtt cccgcagcac ctctgagtcc      420

acagccgctc tgggctgcct ggtgaaggac tatttccccg agcctgtgac cgtgtcctgg      480

aacagcggcg ctctgacctc cggagtgcac acatttcccg ccgtgctgca gtcttccggc      540

ctgtacagcc tgagctctgt ggtgaccgtg ccatccagct ctctgggcac caagacatat      600

acctgtaacg tggatcataa gccctccaat acaaaggtgg acaagcgcgt ggagagcaag      660

tacggaccac catgtcctcc atgcccagct cccgagtttc tgggcggccc tagcgtgttc      720

ctgtttcccc ctaagccaaa ggataccctg atgatcagca ggacccctga ggtgacatgc      780

gtggtggtgg acgtgtccca ggaggaccca gaggtgcagt tcaactggta cgtggacggc      840

gtggaggtgc acaatgccaa gaccaagcct cgggaggagc agtttaattc cacctacaga      900

gtggtgagcg tgctgacagt gctgcatcag gactggctga acggcaagga gtataagtgt      960

aaggtgtcca ataagggcct gccatccagc atcgagaaga ccatcagcaa ggctaagggc     1020

cagcccaggg agcctcaggt gtacacactg ccaccctctc aggaggagat gaccaagaac     1080

caggtgtccc tgacatgcct ggtgaagggc ttctatcctt ccgatatcgc cgtggagtgg     1140

gagagcaatg gccagccaga gaacaattac aagaccacac ctccagtgct ggattctgac     1200

ggctccttct ttctgtattc ccggctgacc gtggacaaga gcagatggca ggagggcaac     1260

gtgtttagct gttctgtgat gcatgaggct ctgcacaatc attacacaca gaagtccctg     1320

agcctgtctc tgggcaag                                                   1338


<210>  76
<211>  654
<212>  DNA
<213>  AB612

<400>  76
gaaattgtgg tgacccagga gccttccctg acagtgagcc caggcggcac agtgaccctg       60

acatgtagaa gctctcagtc tctgctgaac tccagaaccc gcaagacata cctggcttgg      120

gtccaggaga agcctgatca tctgttcacc ggcctgatct attgggcttc caccagggac      180

ccaggaacac ctgctcggtt ttccggaagc ctgctgggag gcaaggccgc tctgaccctg      240

tctggagtgc agccagaaga tgaagccatc tactattgcg tgcagtccta caccctgaga      300

acattcggcg gcggcaccaa gctggagatc aagaggaccg tggctgcccc ctccgtgttc      360

atctttcccc cttccgatga gcagctgaag tccggcacag ccagcgtggt gtgcctgctg      420

aacaatttct accctagaga ggctaaggtg cagtggaagg tggacaacgc cctgcagagc      480

ggcaattctc aggagtccgt gaccgagcag gatagcaagg actctacata ttccctgtcc      540

agcacactga ccctgagcaa ggctgattac gagaagcaca aggtgtatgc ctgtgaggtg      600

acccatcagg gcctgtcttc ccctgtgaca aagtctttca accggggcga gtgc            654


<210>  77
<211>  446
<212>  PRT
<213>  AB613

<400>  77

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Glu Gly Ser Thr Lys Phe Asn Glu Lys Phe 
    50                  55                  60                  


Arg Gly Arg Thr Thr Leu Thr Ala Asp Lys Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Glu Gly Tyr Ser Leu Tyr Tyr Phe Glu Phe Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
            260                 265                 270         


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445     


<210>  78
<211>  219
<212>  PRT
<213>  AB613

<400>  78

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Thr Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Glu 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Asp Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Val Gln 
                85                  90                  95      


Ser Tyr Thr Leu Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  79
<211>  1338
<212>  DNA
<213>  AB613

<400>  79
gaagtgcagc tggtgcagtc tggcgctgag gtgaagaagc ctggctccag cgtcaaggtg       60

agctgcaagg cttctggcta cacctttaca agctactata tccactgggt gcgccaggct      120

ccaggacagg gactggagtg gatgggctgg atctatcctg gcgagggcag caccaagttc      180

aacgagaagt ttaggggccg gaccacactg acagccgata agagcaccaa tacagcttac      240

atggagctgt cttccctgag atctgaggac accgccgtgt acttctgcgc tcgcgagggc      300

tattctctgt attactttga gttttggggt cagggtacta cagtgaccgt gagctctgcc      360

tctaccaagg gcccttccgt gttccctctg gccccatgtt cccgcagcac ctctgagtcc      420

acagccgctc tgggctgcct ggtgaaggac tatttccccg agcctgtgac cgtgtcctgg      480

aacagcggcg ctctgacctc cggagtgcac acatttcccg ccgtgctgca gtcttccggc      540

ctgtacagcc tgagctctgt ggtgaccgtg ccatccagct ctctgggcac caagacatat      600

acctgtaacg tggatcataa gccctccaat acaaaggtgg acaagcgcgt ggagagcaag      660

tacggaccac catgtcctcc atgcccagct cccgagtttc tgggcggccc tagcgtgttc      720

ctgtttcccc ctaagccaaa ggataccctg atgatcagca ggacccctga ggtgacatgc      780

gtggtggtgg acgtgtccca ggaggaccca gaggtgcagt tcaactggta cgtggacggc      840

gtggaggtgc acaatgccaa gaccaagcct cgggaggagc agtttaattc cacctacaga      900

gtggtgagcg tgctgacagt gctgcatcag gactggctga acggcaagga gtataagtgt      960

aaggtgtcca ataagggcct gccatccagc atcgagaaga ccatcagcaa ggctaagggc     1020

cagcccaggg agcctcaggt gtacacactg ccaccctctc aggaggagat gaccaagaac     1080

caggtgtccc tgacatgcct ggtgaagggc ttctatcctt ccgatatcgc cgtggagtgg     1140

gagagcaatg gccagccaga gaacaattac aagaccacac ctccagtgct ggattctgac     1200

ggctccttct ttctgtattc ccggctgacc gtggacaaga gcagatggca ggagggcaac     1260

gtgtttagct gttctgtgat gcatgaggct ctgcacaatc attacacaca gaagtccctg     1320

agcctgtctc tgggcaag                                                   1338


<210>  80
<211>  657
<212>  DNA
<213>  AB613

<400>  80
gacattgtga tgacacagtc tccagactcc ctggccgtgt ccctgggaga gagagctacc       60

atcaactgta agtccagcca gtccctgctg aactctagga ctagaaagac atacctggca      120

tggtaccagc agaagcccgg cgagtctcct aaactgctga tctactgggc ctctaccaga      180

gattccggag tgccagaccg cttctctgga tccggcagcg gcacagactt caccctgaca      240

atctcttccc tgcaggccga ggacgtggcc gtgtactact gcgtgcagtc ttataccctg      300

cgcacatttg gcggcggcac caaggtggag atcaagagga ccgtggctgc cccctccgtg      360

ttcatctttc ccccttccga tgagcagctg aagtccggca cagccagcgt ggtgtgcctg      420

ctgaacaatt tctaccctag agaggctaag gtgcagtgga aggtggacaa cgccctgcag      480

agcggcaatt ctcaggagtc cgtgaccgag caggatagca aggactctac atattccctg      540

tccagcacac tgaccctgag caaggctgat tacgagaagc acaaggtgta tgcctgtgag      600

gtgacccatc agggcctgtc ttcccctgtg acaaagtctt tcaaccgggg cgagtgc         657


<210>  81
<211>  452
<212>  PRT
<213>  AB614

<400>  81

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Arg Ser Lys Ile Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Asp Asn Phe Tyr Gly Ser Thr Tyr Ser Trp Phe 
            100                 105                 110         


Ala Asp Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
        115                 120                 125             


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser 
    130                 135                 140                 


Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
145                 150                 155                 160 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                165                 170                 175     


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            180                 185                 190         


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys 
        195                 200                 205             


Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
    210                 215                 220                 


Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Leu Gly Lys 
    450         


<210>  82
<211>  216
<212>  PRT
<213>  AB614

<400>  82

Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Val Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Ala Thr Asn Tyr Arg Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Arg Thr Val 
            100                 105                 110         


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
        115                 120                 125             


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
    130                 135                 140                 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
145                 150                 155                 160 


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
                165                 170                 175     


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
            180                 185                 190         


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
        195                 200                 205             


Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215     


<210>  83
<211>  1356
<212>  DNA
<213>  AB614

<400>  83
gaggtgcagc tgctggagtc cggaggagga ctggtgcagc caggaggctc cctgaagctg       60

agctgtgctg cctctggctt taccttcaac acatatgcca tgaattgggt gcggcaggct      120

ccaggcaagg gactggagtg ggtgggcagg atcaggtcta agatcaacaa ttatgccacc      180

tactatgctg attccgtgaa ggacaggttc accatctccc gcgacgatag caagaacaca      240

gcctacctgc agatgaacaa tctgaagacc gaggataccg ccatgtacta ctgcgtgaga      300

catgacaact tttacggcag cacatactcc tggttcgctg actggggaca gggcaccctg      360

gtcacagtga gctctgcctc taccaagggc ccttccgtgt tccctctggc cccatgttcc      420

cgcagcacct ctgagtccac agccgctctg ggctgcctgg tgaaggacta tttccccgag      480

cctgtgaccg tgtcctggaa cagcggcgct ctgacctccg gagtgcacac atttcccgcc      540

gtgctgcagt cttccggcct gtacagcctg agctctgtgg tgaccgtgcc atccagctct      600

ctgggcacca agacatatac ctgtaacgtg gatcataagc cctccaatac aaaggtggac      660

aagcgcgtgg agagcaagta cggaccacca tgtcctccat gcccagctcc cgagtttctg      720

ggcggcccta gcgtgttcct gtttccccct aagccaaagg ataccctgat gatcagcagg      780

acccctgagg tgacatgcgt ggtggtggac gtgtcccagg aggacccaga ggtgcagttc      840

aactggtacg tggacggcgt ggaggtgcac aatgccaaga ccaagcctcg ggaggagcag      900

tttaattcca cctacagagt ggtgagcgtg ctgacagtgc tgcatcagga ctggctgaac      960

ggcaaggagt ataagtgtaa ggtgtccaat aagggcctgc catccagcat cgagaagacc     1020

atcagcaagg ctaagggcca gcccagggag cctcaggtgt acacactgcc accctctcag     1080

gaggagatga ccaagaacca ggtgtccctg acatgcctgg tgaagggctt ctatccttcc     1140

gatatcgccg tggagtggga gagcaatggc cagccagaga acaattacaa gaccacacct     1200

ccagtgctgg attctgacgg ctccttcttt ctgtattccc ggctgaccgt ggacaagagc     1260

agatggcagg agggcaacgt gtttagctgt tctgtgatgc atgaggctct gcacaatcat     1320

tacacacaga agtccctgag cctgtctctg ggcaag                               1356


<210>  84
<211>  648
<212>  DNA
<213>  AB614

<400>  84
gagctggtgg tgacccagga gccatctctg acagtgtccc ccggcggcac agtgaccctg       60

acatgtagat ccagcaccgg cgtggtgacc acatccaact acgctaattg ggtgcaggag      120

aagccagatc acctgttcac aggactgatc ggagctacca actacagggc tcctggaaca      180

ccagctcggt ttagcggatc tctgctggga ggcaaggctg ccctgaccct gtccggagtg      240

cagccagagg atgaggccat ctacttctgc gtgctgtggt atagcaatca ttgggtgttc      300

ggaggaggaa ccaagctgac agtgctgagg accgtggctg ccccctccgt gttcatcttt      360

cccccttccg atgagcagct gaagtccggc acagccagcg tggtgtgcct gctgaacaat      420

ttctacccta gagaggctaa ggtgcagtgg aaggtggaca acgccctgca gagcggcaat      480

tctcaggagt ccgtgaccga gcaggatagc aaggactcta catattccct gtccagcaca      540

ctgaccctga gcaaggctga ttacgagaag cacaaggtgt atgcctgtga ggtgacccat      600

cagggcctgt cttcccctgt gacaaagtct ttcaaccggg gcgagtgc                   648


<210>  85
<211>  8
<212>  PRT
<213>  CDR-H1

<400>  85

Gly Phe Asp Phe Asn Thr Tyr Ala 
1               5               


<210>  86
<211>  8
<212>  PRT
<213>  CDR-H1

<400>  86

Gly Phe Thr Phe Asp Thr Tyr Ala 
1               5               


<210>  87
<211>  5
<212>  PRT
<213>  CDR-H1

<400>  87

Asp Tyr Ala Met Asn 
1               5   


<210>  88
<211>  8
<212>  PRT
<213>  CDR-H1

<400>  88

Gly Phe Thr Phe Asn Asp Tyr Ala 
1               5               


<210>  89
<211>  7
<212>  PRT
<213>  CDR-L2

<400>  89

Asp Thr Asn Tyr Arg Ala Pro 
1               5           


<210>  90
<211>  3
<212>  PRT
<213>  CDR-L2

<400>  90

Asp Thr Asn 
1           


<210>  91
<211>  7
<212>  PRT
<213>  CDR-L2

<400>  91

Ala Thr Asp Tyr Arg Ala Pro 
1               5           


<210>  92
<211>  3
<212>  PRT
<213>  CDR-L2

<400>  92

Ala Thr Asp 
1           


<210>  93
<211>  14
<212>  PRT
<213>  CDR-L1

<400>  93

Arg Ser Ser Thr Gly Val Val Thr Thr Ser Asn His Ala Asn 
1               5                   10                  


<210>  94
<211>  9
<212>  PRT
<213>  CDR-L1

<400>  94

Thr Gly Val Val Thr Thr Ser Asn His 
1               5                   


<210>  95
<211>  7
<212>  PRT
<213>  CDR-L2

<400>  95

Ala Thr Asn His Arg Ala Pro 
1               5           


<210>  96
<211>  14
<212>  PRT
<213>  CDR-H3

<400>  96

His Asp Asn His Tyr Gly Ser Thr Tyr Ser Trp Phe Ala Asp 
1               5                   10                  


<210>  97
<211>  16
<212>  PRT
<213>  CDR-H3

<400>  97

Val Arg His Asp Asn His Tyr Gly Ser Thr Tyr Ser Trp Phe Ala Asp 
1               5                   10                  15      


<210>  98
<211>  14
<212>  PRT
<213>  CDR-H3

<400>  98

His Asp Asn Phe His Gly Ser Thr Tyr Ser Trp Phe Ala Asp 
1               5                   10                  


<210>  99
<211>  16
<212>  PRT
<213>  CDR-H3

<400>  99

Val Arg His Asp Asn Phe His Gly Ser Thr Tyr Ser Trp Phe Ala Asp 
1               5                   10                  15      


<210>  100
<211>  14
<212>  PRT
<213>  CDR-H3

<400>  100

His Asp Asn Phe Tyr Gly Ser Thr His Ser Trp Phe Ala Asp 
1               5                   10                  


<210>  101
<211>  16
<212>  PRT
<213>  CDR-H3

<400>  101

Val Arg His Asp Asn Phe Tyr Gly Ser Thr His Ser Trp Phe Ala Asp 
1               5                   10                  15      


<210>  102
<211>  14
<212>  PRT
<213>  CDR-H3

<400>  102

His Asp Asn Phe Tyr Gly Ser Thr Tyr Ser His Phe Ala Asp 
1               5                   10                  


<210>  103
<211>  16
<212>  PRT
<213>  CDR-H3

<400>  103

Val Arg His Asp Asn Phe Tyr Gly Ser Thr Tyr Ser His Phe Ala Asp 
1               5                   10                  15      


<210>  104
<211>  14
<212>  PRT
<213>  CDR-H3

<400>  104

His Asp Asn Phe Tyr Gly Ser Thr Tyr Ser Trp His Ala Asp 
1               5                   10                  


<210>  105
<211>  16
<212>  PRT
<213>  CDR-H3

<400>  105

Val Arg His Asp Asn Phe Tyr Gly Ser Thr Tyr Ser Trp His Ala Asp 
1               5                   10                  15      


<210>  106
<211>  125
<212>  PRT
<213>  AB615ɱ

<400>  106

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Arg Ser Lys Ile Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Asp Asn Phe Tyr Gly Ser Thr Tyr Ser Trp Phe 
            100                 105                 110         


Ala Asp Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  107
<211>  125
<212>  PRT
<213>  AB616ɱ

<400>  107

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Arg Ser Lys Ile Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Asp Asn Phe Tyr Gly Ser Thr Tyr Ser Trp Phe 
            100                 105                 110         


Ala Asp Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  108
<211>  125
<212>  PRT
<213>  AB617ɱ

<400>  108

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asp Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Arg Ser Lys Ile Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Asp Asn Phe Tyr Gly Ser Thr Tyr Ser Trp Phe 
            100                 105                 110         


Ala Asp Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  109
<211>  109
<212>  PRT
<213>  AB618ɱ

<400>  109

Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Val Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Asp Thr Asn Tyr Arg Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  110
<211>  109
<212>  PRT
<213>  AB619ɱ

<400>  110

Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Val Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Ala Thr Asp Tyr Arg Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  111
<211>  125
<212>  PRT
<213>  AB620ɱ

<400>  111

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Arg Ser Lys Ile Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Asp Asn Phe Tyr Gly Ser Thr Tyr Ser Trp Phe 
            100                 105                 110         


Ala Asp Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  112
<211>  109
<212>  PRT
<213>  AB620ɱ

<400>  112

Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Val Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Ala Thr Asp Tyr Arg Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  113
<211>  109
<212>  PRT
<213>  AB621ɱ

<400>  113

Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Val Val Thr Thr Ser 
            20                  25                  30          


Asn His Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Ala Thr Asn Tyr Arg Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  114
<211>  109
<212>  PRT
<213>  AB622ɱ

<400>  114

Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Val Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Ala Thr Asn His Arg Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  115
<211>  125
<212>  PRT
<213>  AB623ɱ

<400>  115

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Arg Ser Lys Ile Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Asp Asn His Tyr Gly Ser Thr Tyr Ser Trp Phe 
            100                 105                 110         


Ala Asp Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  116
<211>  125
<212>  PRT
<213>  AB624ɱ

<400>  116

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Arg Ser Lys Ile Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Asp Asn Phe His Gly Ser Thr Tyr Ser Trp Phe 
            100                 105                 110         


Ala Asp Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  117
<211>  125
<212>  PRT
<213>  AB625ɱ

<400>  117

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Arg Ser Lys Ile Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Asp Asn Phe Tyr Gly Ser Thr His Ser Trp Phe 
            100                 105                 110         


Ala Asp Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  118
<211>  125
<212>  PRT
<213>  AB626ɱ

<400>  118

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Arg Ser Lys Ile Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Asp Asn Phe Tyr Gly Ser Thr Tyr Ser His Phe 
            100                 105                 110         


Ala Asp Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  119
<211>  125
<212>  PRT
<213>  AB627ɱ

<400>  119

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Arg Ser Lys Ile Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Asp Asn Phe Tyr Gly Ser Thr Tyr Ser Trp His 
            100                 105                 110         


Ala Asp Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


