                         б

<110>  ƼҽҩϺ޹˾
 
<120>  ϸǶ϶

<130>  FF00617PCT

<150>  CN202110730083.X
<151>  2021-06-29

<150>  CN202111056553.5
<151>  2021-09-09

<150>  CN202210111505.X
<151>  2022-01-29

<160>  110   

<170>  PatentIn version 3.5

<210>  1
<211>  218
<212>  PRT
<213>  Jagged2

<400>  1

Glu Val Ile Gly Phe Gly Arg Ser Cys Trp Ser Arg Gly Thr Pro Phe 
1               5                   10                  15      


Pro His Gly Ser Ser Trp Val Glu Asp Cys Asn Ser Cys Arg Cys Leu 
            20                  25                  30          


Asp Gly Arg Arg Asp Cys Ser Lys Val Trp Cys Gly Trp Lys Pro Cys 
        35                  40                  45              


Leu Leu Ala Gly Gln Pro Glu Ala Leu Ser Ala Gln Cys Pro Leu Gly 
    50                  55                  60                  


Gln Arg Cys Leu Glu Lys Ala Pro Gly Gln Cys Leu Arg Pro Pro Cys 
65                  70                  75                  80  


Glu Ala Trp Gly Glu Cys Gly Ala Glu Glu Pro Pro Ser Thr Pro Cys 
                85                  90                  95      


Leu Pro Arg Ser Gly His Leu Asp Asn Asn Cys Ala Arg Leu Thr Leu 
            100                 105                 110         


His Phe Asn Arg Asp His Val Pro Gln Gly Thr Thr Val Gly Ala Ile 
        115                 120                 125             


Cys Ser Gly Ile Arg Ser Leu Pro Ala Thr Arg Ala Val Ala Arg Asp 
    130                 135                 140                 


Arg Leu Leu Val Leu Leu Cys Asp Arg Ala Ser Ser Gly Ala Ser Ala 
145                 150                 155                 160 


Val Glu Val Ala Val Ser Phe Ser Pro Ala Arg Asp Leu Pro Asp Ser 
                165                 170                 175     


Ser Leu Ile Gln Gly Ala Ala His Ala Ile Val Ala Ala Ile Thr Gln 
            180                 185                 190         


Arg Gly Asn Ser Ser Leu Leu Leu Ala Val Thr Glu Val Lys Val Glu 
        195                 200                 205             


Thr Val Val Thr Gly Gly Ser Ser Thr Gly 
    210                 215             


<210>  2
<211>  654
<212>  DNA
<213>  Jagged2

<400>  2
gaagtgatcg ggttcgggag atcctgctgg tcccggggca ctccgttccc acacggaagc       60

tcctgggtgg aagactgcaa cagctgccgc tgcctggatg gccgccgtga ctgcagcaag      120

gtgtggtgcg gatggaagcc ttgtctgctg gccggccagc ccgaggccct gagcgcccag      180

tgcccactgg ggcaaaggtg cctggagaag gccccaggcc agtgtctgcg accaccctgt      240

gaggcctggg gggagtgcgg cgcagaagag ccaccgagca ccccctgcct gccacgctcc      300

ggccacctgg acaataactg tgcccgcctc accttgcatt tcaaccgtga ccacgtgccc      360

cagggcacca cggtgggcgc catttgctcc gggatccgct ccctgccagc cacaagggct      420

gtggcacggg accgcctgct ggtgttgctt tgcgaccggg cgtcctcggg ggccagtgct      480

gtggaggtgg ccgtgtcctt cagccctgcc agggacctgc ctgacagcag cctgatccag      540

ggcgcggccc acgccatcgt ggccgccatc acccagcggg ggaacagctc actgctcctg      600

gctgtcaccg aggtcaaggt ggagacggtt gttacgggcg gctcttccac aggt            654


<210>  3
<211>  65
<212>  PRT
<213>  EphrinB2ȫ

<400>  3

Gly Gln Asp Ala Ser Ser Ala Gly Ser Thr Arg Asn Lys Asp Pro Thr 
1               5                   10                  15      


Arg Arg Pro Glu Leu Glu Ala Gly Thr Asn Gly Arg Ser Ser Thr Thr 
            20                  25                  30          


Ser Pro Phe Val Lys Pro Asn Pro Gly Ser Ser Thr Asp Gly Asn Ser 
        35                  40                  45              


Ala Gly His Ser Gly Asn Asn Ile Leu Gly Ser Glu Val Ala Leu Phe 
    50                  55                  60                  


Ala 
65  


<210>  4
<211>  195
<212>  DNA
<213>  EphrinB2ȫ

<400>  4
ggacaagatg caagttctgc tggatcaacc aggaataaag atccaacaag acgtccagaa       60

ctagaagctg gtacaaatgg aagaagttcg acaacaagtc cctttgtaaa accaaatcca      120

ggttctagca cagacggcaa cagcgccgga cattcgggga acaacatcct cggttccgaa      180

gtggccttat ttgca                                                       195


<210>  5
<211>  54
<212>  PRT
<213>  EphrinB2-del1

<400>  5

Gly Gln Asp Ala Thr Arg Arg Pro Glu Leu Glu Ala Gly Thr Asn Gly 
1               5                   10                  15      


Arg Ser Ser Thr Thr Ser Pro Phe Val Lys Pro Asn Pro Gly Ser Ser 
            20                  25                  30          


Thr Asp Gly Asn Ser Ala Gly His Ser Gly Asn Asn Ile Leu Gly Ser 
        35                  40                  45              


Glu Val Ala Leu Phe Ala 
    50                  


<210>  6
<211>  162
<212>  DNA
<213>  EphrinB2-del1

<400>  6
ggacaagatg caacaagacg tccagaacta gaagctggta caaatggaag aagttcgaca       60

acaagtccct ttgtaaaacc aaatccaggt tctagcacag acggcaacag cgccggacat      120

tcggggaaca acatcctcgg ttccgaagtg gccttatttg ca                         162


<210>  7
<211>  52
<212>  PRT
<213>  EphrinB2-del2

<400>  7

Gly Gln Asp Ala Ser Ser Ala Gly Ser Thr Arg Asn Lys Asp Pro Thr 
1               5                   10                  15      


Arg Arg Pro Ser Pro Phe Val Lys Pro Asn Pro Gly Ser Ser Thr Asp 
            20                  25                  30          


Gly Asn Ser Ala Gly His Ser Gly Asn Asn Ile Leu Gly Ser Glu Val 
        35                  40                  45              


Ala Leu Phe Ala 
    50          


<210>  8
<211>  156
<212>  DNA
<213>  EphrinB2-del2

<400>  8
ggacaagatg caagttctgc tggatcaacc aggaataaag atccaacaag acgtccaagt       60

ccctttgtaa aaccaaatcc aggttctagc acagacggca acagcgccgg acattcgggg      120

aacaacatcc tcggttccga agtggcctta tttgca                                156


<210>  9
<211>  41
<212>  PRT
<213>  EphrinB2-del3

<400>  9

Gly Gln Asp Ala Ser Ser Ala Gly Ser Thr Arg Asn Lys Asp Pro Thr 
1               5                   10                  15      


Arg Arg Pro Glu Leu Glu Ala Gly Thr Asn Gly Arg Ser Ser Thr Thr 
            20                  25                  30          


Ser Pro Ser Glu Val Ala Leu Phe Ala 
        35                  40      


<210>  10
<211>  123
<212>  DNA
<213>  EphrinB2-del3

<400>  10
ggacaagatg caagttctgc tggatcaacc aggaataaag atccaacaag acgtccagaa       60

ctagaagctg gtacaaatgg aagaagttcg acaacaagtc cctccgaagt ggccttattt      120

gca                                                                    123


<210>  11
<211>  26
<212>  PRT
<213>  EphrinB2-del23

<400>  11

Gly Gln Asp Ala Ser Ser Ala Gly Ser Thr Arg Asn Lys Asp Pro Thr 
1               5                   10                  15      


Arg Arg Pro Ser Glu Val Ala Leu Phe Ala 
            20                  25      


<210>  12
<211>  78
<212>  DNA
<213>  EphrinB2-del23

<400>  12
ggacaagatg caagttctgc tggatcaacc aggaataaag atccaacaag acgtccatcc       60

gaagtggcct tatttgca                                                     78


<210>  13
<211>  27
<212>  PRT
<213>  Notch1Ĥ

<400>  13

Leu Met Tyr Val Ala Ala Ala Ala Phe Val Leu Leu Phe Phe Val Gly 
1               5                   10                  15      


Cys Gly Val Leu Leu Ser Arg Lys Arg Arg Arg 
            20                  25          


<210>  14
<211>  29
<212>  PRT
<213>  Notch2Ĥ

<400>  14

Leu Leu Tyr Leu Leu Ala Val Ala Val Val Ile Ile Leu Phe Phe Ile 
1               5                   10                  15      


Leu Leu Gly Val Ile Met Ala Lys Arg Lys Arg Lys His 
            20                  25                  


<210>  15
<211>  29
<212>  PRT
<213>  Notch3Ĥ

<400>  15

Leu Leu Pro Leu Leu Val Ala Gly Ala Val Phe Leu Leu Ile Ile Phe 
1               5                   10                  15      


Ile Leu Gly Val Met Val Ala Arg Arg Lys Arg Glu His 
            20                  25                  


<210>  16
<211>  31
<212>  PRT
<213>  Notch4Ĥ

<400>  16

Pro Ile Leu Cys Ser Pro Val Val Gly Val Leu Leu Leu Ala Leu Gly 
1               5                   10                  15      


Ala Leu Leu Val Leu Gln Leu Ile Arg Arg Arg Arg Arg Glu His 
            20                  25                  30      


<210>  17
<211>  27
<212>  PRT
<213>  Notch1Ĥ

<400>  17

Phe Met Tyr Val Ala Ala Ala Ala Phe Val Leu Leu Phe Phe Val Gly 
1               5                   10                  15      


Cys Gly Val Leu Leu Ser Arg Lys Arg Arg Arg 
            20                  25          


<210>  18
<211>  29
<212>  PRT
<213>  Notch2Ĥ

<400>  18

Leu Leu Tyr Leu Leu Ala Val Ala Val Val Ile Ile Leu Phe Ile Ile 
1               5                   10                  15      


Leu Leu Gly Val Ile Met Ala Lys Arg Lys Arg Lys His 
            20                  25                  


<210>  19
<211>  28
<212>  PRT
<213>  Notch3Ĥ

<400>  19

Leu Pro Leu Leu Val Ala Gly Ala Val Leu Leu Leu Val Ile Leu Val 
1               5                   10                  15      


Leu Gly Val Met Val Ala Arg Arg Lys Arg Glu His 
            20                  25              


<210>  20
<211>  31
<212>  PRT
<213>  Notch4Ĥ

<400>  20

Pro Val Leu Cys Ser Pro Val Ala Gly Val Ile Leu Leu Ala Leu Gly 
1               5                   10                  15      


Ala Leu Leu Val Leu Gln Leu Ile Arg Arg Arg Arg Arg Glu His 
            20                  25                  30      


<210>  21
<211>  28
<212>  PRT
<213>  APLP2Ĥ

<400>  21

Ser Ala Leu Ile Gly Leu Leu Val Ile Ala Val Ala Ile Ala Thr Val 
1               5                   10                  15      


Ile Val Ile Ser Leu Val Met Leu Arg Lys Arg Gln 
            20                  25              


<210>  22
<211>  5
<212>  PRT
<213>  Notch1STS

<400>  22

Arg Lys Arg Arg Arg 
1               5   


<210>  23
<211>  6
<212>  PRT
<213>  Notch2STS

<400>  23

Lys Arg Lys Arg Lys His 
1               5       


<210>  24
<211>  6
<212>  PRT
<213>  Notch3STS

<400>  24

Arg Arg Lys Arg Glu His 
1               5       


<210>  25
<211>  7
<212>  PRT
<213>  Notch4STS

<400>  25

Arg Arg Arg Arg Arg Glu His 
1               5           


<210>  26
<211>  4
<212>  PRT
<213>  APLP2STS

<400>  26

Arg Lys Arg Gln 
1               


<210>  27
<211>  211
<212>  PRT
<213>  GAL4-VP64

<400>  27

Met Lys Leu Leu Ser Ser Ile Glu Gln Ala Cys Asp Ile Cys Arg Leu 
1               5                   10                  15      


Lys Lys Leu Lys Cys Ser Lys Glu Lys Pro Lys Cys Ala Lys Cys Leu 
            20                  25                  30          


Lys Asn Asn Trp Glu Cys Arg Tyr Ser Pro Lys Thr Lys Arg Ser Pro 
        35                  40                  45              


Leu Thr Arg Ala His Leu Thr Glu Val Glu Ser Arg Leu Glu Arg Leu 
    50                  55                  60                  


Glu Gln Leu Phe Leu Leu Ile Phe Pro Arg Glu Asp Leu Asp Met Ile 
65                  70                  75                  80  


Leu Lys Met Asp Ser Leu Gln Asp Ile Lys Ala Leu Leu Thr Gly Leu 
                85                  90                  95      


Phe Val Gln Asp Asn Val Asn Lys Asp Ala Val Thr Asp Arg Leu Ala 
            100                 105                 110         


Ser Val Glu Thr Asp Met Pro Leu Thr Leu Arg Gln His Arg Ile Ser 
        115                 120                 125             


Ala Thr Ser Ser Ser Glu Glu Ser Ser Asn Lys Gly Gln Arg Gln Leu 
    130                 135                 140                 


Thr Val Ser Ala Ala Ala Gly Gly Ser Gly Gly Ser Gly Gly Ser Asp 
145                 150                 155                 160 


Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp 
                165                 170                 175     


Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp 
            180                 185                 190         


Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met 
        195                 200                 205             


Leu Gly Ser 
    210     


<210>  28
<211>  245
<212>  PRT
<213>  synJagged2ECؽṹ

<400>  28

Glu Val Ile Gly Phe Gly Arg Ser Cys Trp Ser Arg Gly Thr Pro Phe 
1               5                   10                  15      


Pro His Gly Ser Ser Trp Val Glu Asp Cys Asn Ser Cys Arg Cys Leu 
            20                  25                  30          


Asp Gly Arg Arg Asp Cys Ser Lys Val Trp Cys Gly Trp Lys Pro Cys 
        35                  40                  45              


Leu Leu Ala Gly Gln Pro Glu Ala Leu Ser Ala Gln Cys Pro Leu Gly 
    50                  55                  60                  


Gln Arg Cys Leu Glu Lys Ala Pro Gly Gln Cys Leu Arg Pro Pro Cys 
65                  70                  75                  80  


Glu Ala Trp Gly Glu Cys Gly Ala Glu Glu Pro Pro Ser Thr Pro Cys 
                85                  90                  95      


Leu Pro Arg Ser Gly His Leu Asp Asn Asn Cys Ala Arg Leu Thr Leu 
            100                 105                 110         


His Phe Asn Arg Asp His Val Pro Gln Gly Thr Thr Val Gly Ala Ile 
        115                 120                 125             


Cys Ser Gly Ile Arg Ser Leu Pro Ala Thr Arg Ala Val Ala Arg Asp 
    130                 135                 140                 


Arg Leu Leu Val Leu Leu Cys Asp Arg Ala Ser Ser Gly Ala Ser Ala 
145                 150                 155                 160 


Val Glu Val Ala Val Ser Phe Ser Pro Ala Arg Asp Leu Pro Asp Ser 
                165                 170                 175     


Ser Leu Ile Gln Gly Ala Ala His Ala Ile Val Ala Ala Ile Thr Gln 
            180                 185                 190         


Arg Gly Asn Ser Ser Leu Leu Leu Ala Val Thr Glu Val Lys Val Glu 
        195                 200                 205             


Thr Val Val Thr Gly Gly Ser Ser Thr Gly Leu Met Tyr Val Ala Ala 
    210                 215                 220                 


Ala Ala Phe Val Leu Leu Phe Phe Val Gly Cys Gly Val Leu Leu Ser 
225                 230                 235                 240 


Arg Lys Arg Arg Arg 
                245 


<210>  29
<211>  92
<212>  PRT
<213>  synEphrinB2ECؽṹ

<400>  29

Gly Gln Asp Ala Ser Ser Ala Gly Ser Thr Arg Asn Lys Asp Pro Thr 
1               5                   10                  15      


Arg Arg Pro Glu Leu Glu Ala Gly Thr Asn Gly Arg Ser Ser Thr Thr 
            20                  25                  30          


Ser Pro Phe Val Lys Pro Asn Pro Gly Ser Ser Thr Asp Gly Asn Ser 
        35                  40                  45              


Ala Gly His Ser Gly Asn Asn Ile Leu Gly Ser Glu Val Ala Leu Phe 
    50                  55                  60                  


Ala Leu Met Tyr Val Ala Ala Ala Ala Phe Val Leu Leu Phe Phe Val 
65                  70                  75                  80  


Gly Cys Gly Val Leu Leu Ser Arg Lys Arg Arg Arg 
                85                  90          


<210>  30
<211>  93
<212>  PRT
<213>  synEphrinB2EC-2ؽṹ

<400>  30

Gly Gln Asp Ala Ser Ser Ala Gly Ser Thr Arg Asn Lys Asp Pro Thr 
1               5                   10                  15      


Arg Arg Pro Glu Leu Glu Ala Gly Thr Asn Gly Arg Ser Ser Thr Thr 
            20                  25                  30          


Ser Pro Phe Val Lys Pro Asn Pro Gly Ser Ser Thr Asp Gly Asn Ser 
        35                  40                  45              


Ala Gly His Ser Gly Asn Asn Ile Leu Gly Ser Glu Val Ala Leu Phe 
    50                  55                  60                  


Ala Leu Met Tyr Val Ala Ala Ala Ala Phe Val Leu Leu Phe Phe Val 
65                  70                  75                  80  


Gly Cys Gly Val Leu Leu Ser Lys Arg Lys Arg Lys His 
                85                  90              


<210>  31
<211>  93
<212>  PRT
<213>  synEphrinB2EC-3ؽṹ

<400>  31

Gly Gln Asp Ala Ser Ser Ala Gly Ser Thr Arg Asn Lys Asp Pro Thr 
1               5                   10                  15      


Arg Arg Pro Glu Leu Glu Ala Gly Thr Asn Gly Arg Ser Ser Thr Thr 
            20                  25                  30          


Ser Pro Phe Val Lys Pro Asn Pro Gly Ser Ser Thr Asp Gly Asn Ser 
        35                  40                  45              


Ala Gly His Ser Gly Asn Asn Ile Leu Gly Ser Glu Val Ala Leu Phe 
    50                  55                  60                  


Ala Leu Met Tyr Val Ala Ala Ala Ala Phe Val Leu Leu Phe Phe Val 
65                  70                  75                  80  


Gly Cys Gly Val Leu Leu Ser Arg Arg Lys Arg Glu His 
                85                  90              


<210>  32
<211>  94
<212>  PRT
<213>  synEphrinB2EC-4ؽṹ

<400>  32

Gly Gln Asp Ala Ser Ser Ala Gly Ser Thr Arg Asn Lys Asp Pro Thr 
1               5                   10                  15      


Arg Arg Pro Glu Leu Glu Ala Gly Thr Asn Gly Arg Ser Ser Thr Thr 
            20                  25                  30          


Ser Pro Phe Val Lys Pro Asn Pro Gly Ser Ser Thr Asp Gly Asn Ser 
        35                  40                  45              


Ala Gly His Ser Gly Asn Asn Ile Leu Gly Ser Glu Val Ala Leu Phe 
    50                  55                  60                  


Ala Leu Met Tyr Val Ala Ala Ala Ala Phe Val Leu Leu Phe Phe Val 
65                  70                  75                  80  


Gly Cys Gly Val Leu Leu Ser Arg Arg Arg Arg Arg Glu His 
                85                  90                  


<210>  33
<211>  94
<212>  PRT
<213>  synEphrinB2EC-5ؽṹ

<400>  33

Gly Gln Asp Ala Ser Ser Ala Gly Ser Thr Arg Asn Lys Asp Pro Thr 
1               5                   10                  15      


Arg Arg Pro Glu Leu Glu Ala Gly Thr Asn Gly Arg Ser Ser Thr Thr 
            20                  25                  30          


Ser Pro Phe Val Lys Pro Asn Pro Gly Ser Ser Thr Asp Gly Asn Ser 
        35                  40                  45              


Ala Gly His Ser Gly Asn Asn Ile Leu Gly Ser Glu Val Ala Leu Phe 
    50                  55                  60                  


Ala Leu Leu Tyr Leu Leu Ala Val Ala Val Val Ile Ile Leu Phe Ile 
65                  70                  75                  80  


Ile Leu Leu Gly Val Ile Met Ala Lys Arg Lys Arg Lys His 
                85                  90                  


<210>  34
<211>  93
<212>  PRT
<213>  synEphrinB2EC-6ؽṹ

<400>  34

Gly Gln Asp Ala Ser Ser Ala Gly Ser Thr Arg Asn Lys Asp Pro Thr 
1               5                   10                  15      


Arg Arg Pro Glu Leu Glu Ala Gly Thr Asn Gly Arg Ser Ser Thr Thr 
            20                  25                  30          


Ser Pro Phe Val Lys Pro Asn Pro Gly Ser Ser Thr Asp Gly Asn Ser 
        35                  40                  45              


Ala Gly His Ser Gly Asn Asn Ile Leu Gly Ser Glu Val Ala Leu Phe 
    50                  55                  60                  


Ala Leu Pro Leu Leu Val Ala Gly Ala Val Leu Leu Leu Val Ile Leu 
65                  70                  75                  80  


Val Leu Gly Val Met Val Ala Arg Arg Lys Arg Glu His 
                85                  90              


<210>  35
<211>  96
<212>  PRT
<213>  synEphrinB2EC-7ؽṹ

<400>  35

Gly Gln Asp Ala Ser Ser Ala Gly Ser Thr Arg Asn Lys Asp Pro Thr 
1               5                   10                  15      


Arg Arg Pro Glu Leu Glu Ala Gly Thr Asn Gly Arg Ser Ser Thr Thr 
            20                  25                  30          


Ser Pro Phe Val Lys Pro Asn Pro Gly Ser Ser Thr Asp Gly Asn Ser 
        35                  40                  45              


Ala Gly His Ser Gly Asn Asn Ile Leu Gly Ser Glu Val Ala Leu Phe 
    50                  55                  60                  


Ala Pro Val Leu Cys Ser Pro Val Ala Gly Val Ile Leu Leu Ala Leu 
65                  70                  75                  80  


Gly Ala Leu Leu Val Leu Gln Leu Ile Arg Arg Arg Arg Arg Glu His 
                85                  90                  95      


<210>  36
<211>  93
<212>  PRT
<213>  synEphrinB2EC-APLP2TMؽṹ

<400>  36

Gly Gln Asp Ala Ser Ser Ala Gly Ser Thr Arg Asn Lys Asp Pro Thr 
1               5                   10                  15      


Arg Arg Pro Glu Leu Glu Ala Gly Thr Asn Gly Arg Ser Ser Thr Thr 
            20                  25                  30          


Ser Pro Phe Val Lys Pro Asn Pro Gly Ser Ser Thr Asp Gly Asn Ser 
        35                  40                  45              


Ala Gly His Ser Gly Asn Asn Ile Leu Gly Ser Glu Val Ala Leu Phe 
    50                  55                  60                  


Ala Ser Ala Leu Ile Gly Leu Leu Val Ile Ala Val Ala Ile Ala Thr 
65                  70                  75                  80  


Val Ile Val Ile Ser Leu Val Met Leu Arg Lys Arg Gln 
                85                  90              


<210>  37
<211>  81
<212>  PRT
<213>  synEphrinB2EC-del1ؽṹ

<400>  37

Gly Gln Asp Ala Thr Arg Arg Pro Glu Leu Glu Ala Gly Thr Asn Gly 
1               5                   10                  15      


Arg Ser Ser Thr Thr Ser Pro Phe Val Lys Pro Asn Pro Gly Ser Ser 
            20                  25                  30          


Thr Asp Gly Asn Ser Ala Gly His Ser Gly Asn Asn Ile Leu Gly Ser 
        35                  40                  45              


Glu Val Ala Leu Phe Ala Leu Met Tyr Val Ala Ala Ala Ala Phe Val 
    50                  55                  60                  


Leu Leu Phe Phe Val Gly Cys Gly Val Leu Leu Ser Arg Lys Arg Arg 
65                  70                  75                  80  


Arg 
    


<210>  38
<211>  79
<212>  PRT
<213>  synEphrinB2EC-del2ؽṹ

<400>  38

Gly Gln Asp Ala Ser Ser Ala Gly Ser Thr Arg Asn Lys Asp Pro Thr 
1               5                   10                  15      


Arg Arg Pro Ser Pro Phe Val Lys Pro Asn Pro Gly Ser Ser Thr Asp 
            20                  25                  30          


Gly Asn Ser Ala Gly His Ser Gly Asn Asn Ile Leu Gly Ser Glu Val 
        35                  40                  45              


Ala Leu Phe Ala Leu Met Tyr Val Ala Ala Ala Ala Phe Val Leu Leu 
    50                  55                  60                  


Phe Phe Val Gly Cys Gly Val Leu Leu Ser Arg Lys Arg Arg Arg 
65                  70                  75                  


<210>  39
<211>  68
<212>  PRT
<213>  synEphrinB2EC-del3ؽṹ

<400>  39

Gly Gln Asp Ala Ser Ser Ala Gly Ser Thr Arg Asn Lys Asp Pro Thr 
1               5                   10                  15      


Arg Arg Pro Glu Leu Glu Ala Gly Thr Asn Gly Arg Ser Ser Thr Thr 
            20                  25                  30          


Ser Pro Ser Glu Val Ala Leu Phe Ala Leu Met Tyr Val Ala Ala Ala 
        35                  40                  45              


Ala Phe Val Leu Leu Phe Phe Val Gly Cys Gly Val Leu Leu Ser Arg 
    50                  55                  60                  


Lys Arg Arg Arg 
65              


<210>  40
<211>  69
<212>  PRT
<213>  synEphrinB2EC-del3-2ؽṹ

<400>  40

Gly Gln Asp Ala Ser Ser Ala Gly Ser Thr Arg Asn Lys Asp Pro Thr 
1               5                   10                  15      


Arg Arg Pro Glu Leu Glu Ala Gly Thr Asn Gly Arg Ser Ser Thr Thr 
            20                  25                  30          


Ser Pro Ser Glu Val Ala Leu Phe Ala Leu Met Tyr Val Ala Ala Ala 
        35                  40                  45              


Ala Phe Val Leu Leu Phe Phe Val Gly Cys Gly Val Leu Leu Ser Lys 
    50                  55                  60                  


Arg Lys Arg Lys His 
65                  


<210>  41
<211>  53
<212>  PRT
<213>  synEphrinB2EC-del23ؽṹ

<400>  41

Gly Gln Asp Ala Ser Ser Ala Gly Ser Thr Arg Asn Lys Asp Pro Thr 
1               5                   10                  15      


Arg Arg Pro Ser Glu Val Ala Leu Phe Ala Leu Met Tyr Val Ala Ala 
            20                  25                  30          


Ala Ala Phe Val Leu Leu Phe Phe Val Gly Cys Gly Val Leu Leu Ser 
        35                  40                  45              


Arg Lys Arg Arg Arg 
    50              


<210>  42
<211>  243
<212>  PRT
<213>  antiGPC3-scFv

<400>  42

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ala Ile His Pro Gly Ser Gly Asp Thr Ala Tyr Asn Gln Arg Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Ser Tyr Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr 
    130                 135                 140                 


Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val 
145                 150                 155                 160 


His Ser Asn Gly Asn Thr Tyr Leu Gln Trp Tyr Leu Gln Lys Pro Gly 
                165                 170                 175     


Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly 
            180                 185                 190         


Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser 
    210                 215                 220                 


Gln Ser Ile Tyr Val Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu 
225                 230                 235                 240 


Ile Lys Arg 
            


<210>  43
<211>  239
<212>  PRT
<213>  antiEGFRvIII-scFv

<400>  43

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys His Ala Ser Gln Asp Ile Asn Val Asn 
            20                  25                  30          


Ile Gly Trp Leu Gln Gln Lys Pro Gly Lys Ala Phe Lys Gly Leu Ile 
        35                  40                  45              


Tyr His Gly Lys Asn Leu Glu Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Asn Gln Tyr Glu Asn Ile Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Gln Leu Val 
        115                 120                 125             


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
    130                 135                 140                 


Cys Ala Val Ser Gly Tyr Ser Ile Thr Ser Asp Tyr Ala Trp Asn Trp 
145                 150                 155                 160 


Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu Gly Tyr Ile Ser 
                165                 170                 175     


Tyr Arg Gly Arg Thr Gln Tyr Asn Pro Ser Leu Lys Ser Arg Ile Ser 
            180                 185                 190         


Ile Thr Arg Asp Asn Ser Lys Asn Thr Phe Phe Leu Gln Leu Asn Ser 
        195                 200                 205             


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Met Gly Lys 
    210                 215                 220                 


Asn Trp Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
225                 230                 235                 


<210>  44
<211>  247
<212>  PRT
<213>  antiMesothelin-scFv

<400>  44

Gln Met Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ser Arg Ser Gly Thr Thr Val Val Asn His Asp Ala Phe Asp 
            100                 105                 110         


Ile Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr 
    130                 135                 140                 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Gln Val Ile Ser Arg Ala Leu Ala Trp Tyr Gln 
                165                 170                 175     


Gln Thr Pro Gly Lys Pro Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asn 
            180                 185                 190         


Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Thr Ile Ser Arg Leu Gln Pro Glu Asp Phe Ala Thr 
    210                 215                 220                 


Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Leu Glu Ile Lys Arg 
                245         


<210>  45
<211>  244
<212>  PRT
<213>  antiFAP-scFv

<400>  45

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ala Ala Asp Arg Asp Tyr Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val 
    130                 135                 140                 


Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu 
145                 150                 155                 160 


Leu His Pro Asn Gly Phe Asn His Leu Tyr Trp Tyr Leu Gln Lys Pro 
                165                 170                 175     


Gly Gln Ser Pro Gln Leu Leu Ile Tyr Val Gly Gly Asn Arg Ala Ser 
            180                 185                 190         


Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Arg Asn Asn Lys Asn Arg Thr Phe Gly Gln Gly Thr Lys Val 
225                 230                 235                 240 


Glu Ile Lys Arg 
                


<210>  46
<211>  247
<212>  PRT
<213>  anti Claudin18.2 scFv

<400>  46

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Ile Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Tyr Asn Trp His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile His Tyr Thr Gly Ser Thr Asn Tyr Asn Pro Ala Leu 
    50                  55                  60                  


Arg Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ile Tyr Asn Gly Asn Ser Phe Pro Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu 
    130                 135                 140                 


Ala Val Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln 
145                 150                 155                 160 


Ser Leu Phe Asn Ser Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr 
            180                 185                 190         


Arg Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Gln Asn Ala Tyr Ser Phe Pro Tyr Thr Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Leu Glu Ile Lys Arg 
                245         


<210>  47
<211>  241
<212>  PRT
<213>  antiCLL1-scFv

<400>  47

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Asn Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Phe Asn Pro Gly Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Thr Ser Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
    130                 135                 140                 


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln 
145                 150                 155                 160 


Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
                165                 170                 175     


Pro Lys Leu Leu Ile Asp Val Ala Ser Ser Leu Gln Ser Gly Val Pro 
            180                 185                 190         


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
        195                 200                 205             


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser 
    210                 215                 220                 


Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
225                 230                 235                 240 


Arg 
    


<210>  48
<211>  144
<212>  PRT
<213>  UAS

<400>  48

Ala Ala Gly Cys Thr Thr Gly Ala Thr Ala Thr Cys Gly Ala Ala Thr 
1               5                   10                  15      


Thr Cys Gly Gly Ala Gly Cys Ala Cys Thr Gly Thr Cys Cys Thr Cys 
            20                  25                  30          


Cys Gly Ala Ala Cys Gly Thr Cys Gly Gly Ala Gly Cys Ala Cys Thr 
        35                  40                  45              


Gly Thr Cys Cys Thr Cys Cys Gly Ala Ala Cys Gly Thr Cys Gly Gly 
    50                  55                  60                  


Ala Gly Cys Ala Cys Thr Gly Thr Cys Cys Thr Cys Cys Gly Ala Ala 
65                  70                  75                  80  


Cys Gly Thr Cys Gly Gly Ala Gly Cys Ala Cys Thr Gly Thr Cys Cys 
                85                  90                  95      


Thr Cys Cys Gly Ala Ala Cys Gly Gly Ala Gly Cys Ala Thr Gly Thr 
            100                 105                 110         


Cys Cys Thr Cys Cys Gly Ala Ala Cys Gly Thr Cys Gly Gly Ala Gly 
        115                 120                 125             


Cys Ala Cys Thr Gly Thr Cys Cys Thr Cys Cys Gly Ala Ala Cys Gly 
    130                 135                 140                 


<210>  49
<211>  288
<212>  PRT
<213>  UAS-CMV

<400>  49

Ala Ala Gly Cys Thr Thr Gly Ala Thr Ala Thr Cys Gly Ala Ala Thr 
1               5                   10                  15      


Thr Cys Gly Gly Ala Gly Cys Ala Cys Thr Gly Thr Cys Cys Thr Cys 
            20                  25                  30          


Cys Gly Ala Ala Cys Gly Thr Cys Gly Gly Ala Gly Cys Ala Cys Thr 
        35                  40                  45              


Gly Thr Cys Cys Thr Cys Cys Gly Ala Ala Cys Gly Thr Cys Gly Gly 
    50                  55                  60                  


Ala Gly Cys Ala Cys Thr Gly Thr Cys Cys Thr Cys Cys Gly Ala Ala 
65                  70                  75                  80  


Cys Gly Thr Cys Gly Gly Ala Gly Cys Ala Cys Thr Gly Thr Cys Cys 
                85                  90                  95      


Thr Cys Cys Gly Ala Ala Cys Gly Gly Ala Gly Cys Ala Thr Gly Thr 
            100                 105                 110         


Cys Cys Thr Cys Cys Gly Ala Ala Cys Gly Thr Cys Gly Gly Ala Gly 
        115                 120                 125             


Cys Ala Cys Thr Gly Thr Cys Cys Thr Cys Cys Gly Ala Ala Cys Gly 
    130                 135                 140                 


Ala Cys Thr Ala Gly Thr Thr Ala Gly Gly Cys Gly Thr Gly Thr Ala 
145                 150                 155                 160 


Cys Gly Gly Thr Gly Gly Gly Ala Gly Gly Cys Cys Thr Ala Thr Ala 
                165                 170                 175     


Thr Ala Ala Gly Cys Ala Gly Ala Gly Cys Thr Cys Gly Thr Thr Thr 
            180                 185                 190         


Ala Gly Thr Gly Ala Ala Cys Cys Gly Thr Cys Ala Gly Ala Thr Cys 
        195                 200                 205             


Gly Cys Cys Thr Gly Gly Ala Gly Ala Cys Gly Cys Cys Ala Thr Cys 
    210                 215                 220                 


Cys Ala Cys Gly Cys Thr Gly Thr Thr Thr Thr Gly Ala Cys Cys Thr 
225                 230                 235                 240 


Cys Cys Ala Thr Ala Gly Ala Ala Gly Ala Cys Ala Cys Cys Gly Gly 
                245                 250                 255     


Gly Ala Cys Cys Gly Ala Thr Cys Cys Ala Gly Cys Cys Thr Cys Thr 
            260                 265                 270         


Cys Gly Ala Cys Ala Thr Thr Cys Gly Thr Thr Gly Gly Ala Thr Cys 
        275                 280                 285             


<210>  50
<211>  545
<212>  PRT
<213>  CD123-synEphrinB2EC

<400>  50

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Asp Ser Phe Tyr Gly Gly Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Thr 
    130                 135                 140                 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
145                 150                 155                 160 


Gln Ser Ile Ser Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
                165                 170                 175     


Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val 
            180                 185                 190         


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Tyr Ser Ser Tyr Lys Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
225                 230                 235                 240 


Lys Arg Gly Gln Asp Ala Ser Ser Ala Gly Ser Thr Arg Asn Lys Asp 
                245                 250                 255     


Pro Thr Arg Arg Pro Glu Leu Glu Ala Gly Thr Asn Gly Arg Ser Ser 
            260                 265                 270         


Thr Thr Ser Pro Phe Val Lys Pro Asn Pro Gly Ser Ser Thr Asp Gly 
        275                 280                 285             


Asn Ser Ala Gly His Ser Gly Asn Asn Ile Leu Gly Ser Glu Val Ala 
    290                 295                 300                 


Leu Phe Ala Leu Met Tyr Val Ala Ala Ala Ala Phe Val Leu Leu Phe 
305                 310                 315                 320 


Phe Val Gly Cys Gly Val Leu Leu Ser Arg Lys Arg Arg Arg Met Lys 
                325                 330                 335     


Leu Leu Ser Ser Ile Glu Gln Ala Cys Asp Ile Cys Arg Leu Lys Lys 
            340                 345                 350         


Leu Lys Cys Ser Lys Glu Lys Pro Lys Cys Ala Lys Cys Leu Lys Asn 
        355                 360                 365             


Asn Trp Glu Cys Arg Tyr Ser Pro Lys Thr Lys Arg Ser Pro Leu Thr 
    370                 375                 380                 


Arg Ala His Leu Thr Glu Val Glu Ser Arg Leu Glu Arg Leu Glu Gln 
385                 390                 395                 400 


Leu Phe Leu Leu Ile Phe Pro Arg Glu Asp Leu Asp Met Ile Leu Lys 
                405                 410                 415     


Met Asp Ser Leu Gln Asp Ile Lys Ala Leu Leu Thr Gly Leu Phe Val 
            420                 425                 430         


Gln Asp Asn Val Asn Lys Asp Ala Val Thr Asp Arg Leu Ala Ser Val 
        435                 440                 445             


Glu Thr Asp Met Pro Leu Thr Leu Arg Gln His Arg Ile Ser Ala Thr 
    450                 455                 460                 


Ser Ser Ser Glu Glu Ser Ser Asn Lys Gly Gln Arg Gln Leu Thr Val 
465                 470                 475                 480 


Ser Ala Ala Ala Gly Gly Ser Gly Gly Ser Gly Gly Ser Asp Ala Leu 
                485                 490                 495     


Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe 
            500                 505                 510         


Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp 
        515                 520                 525             


Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly 
    530                 535                 540                 


Ser 
545 


<210>  51
<211>  709
<212>  PRT
<213>  GPC3-synJagged2EC

<400>  51

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Glu Val Gln Leu Val Gln 
1               5                   10                  15      


Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys 
            20                  25                  30          


Lys Ala Ser Gly Tyr Thr Phe Ser Asp Tyr Glu Met His Trp Val Arg 
        35                  40                  45              


Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Ala Ile His Pro Gly 
    50                  55                  60                  


Ser Gly Asp Thr Ala Tyr Asn Gln Arg Phe Lys Gly Arg Val Thr Ile 
65                  70                  75                  80  


Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu 
                85                  90                  95      


Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Phe Tyr Ser Tyr 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met 
    130                 135                 140                 


Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly Glu Pro Ala Ser 
145                 150                 155                 160 


Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr 
                165                 170                 175     


Tyr Leu Gln Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu 
            180                 185                 190         


Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser 
        195                 200                 205             


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu 
    210                 215                 220                 


Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Ser Ile Tyr Val Pro 
225                 230                 235                 240 


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Glu Val Ile 
                245                 250                 255     


Gly Phe Gly Arg Ser Cys Trp Ser Arg Gly Thr Pro Phe Pro His Gly 
            260                 265                 270         


Ser Ser Trp Val Glu Asp Cys Asn Ser Cys Arg Cys Leu Asp Gly Arg 
        275                 280                 285             


Arg Asp Cys Ser Lys Val Trp Cys Gly Trp Lys Pro Cys Leu Leu Ala 
    290                 295                 300                 


Gly Gln Pro Glu Ala Leu Ser Ala Gln Cys Pro Leu Gly Gln Arg Cys 
305                 310                 315                 320 


Leu Glu Lys Ala Pro Gly Gln Cys Leu Arg Pro Pro Cys Glu Ala Trp 
                325                 330                 335     


Gly Glu Cys Gly Ala Glu Glu Pro Pro Ser Thr Pro Cys Leu Pro Arg 
            340                 345                 350         


Ser Gly His Leu Asp Asn Asn Cys Ala Arg Leu Thr Leu His Phe Asn 
        355                 360                 365             


Arg Asp His Val Pro Gln Gly Thr Thr Val Gly Ala Ile Cys Ser Gly 
    370                 375                 380                 


Ile Arg Ser Leu Pro Ala Thr Arg Ala Val Ala Arg Asp Arg Leu Leu 
385                 390                 395                 400 


Val Leu Leu Cys Asp Arg Ala Ser Ser Gly Ala Ser Ala Val Glu Val 
                405                 410                 415     


Ala Val Ser Phe Ser Pro Ala Arg Asp Leu Pro Asp Ser Ser Leu Ile 
            420                 425                 430         


Gln Gly Ala Ala His Ala Ile Val Ala Ala Ile Thr Gln Arg Gly Asn 
        435                 440                 445             


Ser Ser Leu Leu Leu Ala Val Thr Glu Val Lys Val Glu Thr Val Val 
    450                 455                 460                 


Thr Gly Gly Ser Ser Thr Gly Leu Met Tyr Val Ala Ala Ala Ala Phe 
465                 470                 475                 480 


Val Leu Leu Phe Phe Val Gly Cys Gly Val Leu Leu Ser Arg Lys Arg 
                485                 490                 495     


Arg Arg Met Lys Leu Leu Ser Ser Ile Glu Gln Ala Cys Asp Ile Cys 
            500                 505                 510         


Arg Leu Lys Lys Leu Lys Cys Ser Lys Glu Lys Pro Lys Cys Ala Lys 
        515                 520                 525             


Cys Leu Lys Asn Asn Trp Glu Cys Arg Tyr Ser Pro Lys Thr Lys Arg 
    530                 535                 540                 


Ser Pro Leu Thr Arg Ala His Leu Thr Glu Val Glu Ser Arg Leu Glu 
545                 550                 555                 560 


Arg Leu Glu Gln Leu Phe Leu Leu Ile Phe Pro Arg Glu Asp Leu Asp 
                565                 570                 575     


Met Ile Leu Lys Met Asp Ser Leu Gln Asp Ile Lys Ala Leu Leu Thr 
            580                 585                 590         


Gly Leu Phe Val Gln Asp Asn Val Asn Lys Asp Ala Val Thr Asp Arg 
        595                 600                 605             


Leu Ala Ser Val Glu Thr Asp Met Pro Leu Thr Leu Arg Gln His Arg 
    610                 615                 620                 


Ile Ser Ala Thr Ser Ser Ser Glu Glu Ser Ser Asn Lys Gly Gln Arg 
625                 630                 635                 640 


Gln Leu Thr Val Ser Ala Ala Ala Gly Gly Ser Gly Gly Ser Gly Gly 
                645                 650                 655     


Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala 
            660                 665                 670         


Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp 
        675                 680                 685             


Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu 
    690                 695                 700                 


Asp Met Leu Gly Ser 
705                 


<210>  52
<211>  556
<212>  PRT
<213>  GPC3-EphrinB2EC

<400>  52

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Glu Val Gln Leu Val Gln 
1               5                   10                  15      


Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys 
            20                  25                  30          


Lys Ala Ser Gly Tyr Thr Phe Ser Asp Tyr Glu Met His Trp Val Arg 
        35                  40                  45              


Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Ala Ile His Pro Gly 
    50                  55                  60                  


Ser Gly Asp Thr Ala Tyr Asn Gln Arg Phe Lys Gly Arg Val Thr Ile 
65                  70                  75                  80  


Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu 
                85                  90                  95      


Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Phe Tyr Ser Tyr 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met 
    130                 135                 140                 


Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly Glu Pro Ala Ser 
145                 150                 155                 160 


Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr 
                165                 170                 175     


Tyr Leu Gln Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu 
            180                 185                 190         


Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser 
        195                 200                 205             


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu 
    210                 215                 220                 


Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Ser Ile Tyr Val Pro 
225                 230                 235                 240 


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Gly Gln Asp 
                245                 250                 255     


Ala Ser Ser Ala Gly Ser Thr Arg Asn Lys Asp Pro Thr Arg Arg Pro 
            260                 265                 270         


Glu Leu Glu Ala Gly Thr Asn Gly Arg Ser Ser Thr Thr Ser Pro Phe 
        275                 280                 285             


Val Lys Pro Asn Pro Gly Ser Ser Thr Asp Gly Asn Ser Ala Gly His 
    290                 295                 300                 


Ser Gly Asn Asn Ile Leu Gly Ser Glu Val Ala Leu Phe Ala Leu Met 
305                 310                 315                 320 


Tyr Val Ala Ala Ala Ala Phe Val Leu Leu Phe Phe Val Gly Cys Gly 
                325                 330                 335     


Val Leu Leu Ser Arg Lys Arg Arg Arg Met Lys Leu Leu Ser Ser Ile 
            340                 345                 350         


Glu Gln Ala Cys Asp Ile Cys Arg Leu Lys Lys Leu Lys Cys Ser Lys 
        355                 360                 365             


Glu Lys Pro Lys Cys Ala Lys Cys Leu Lys Asn Asn Trp Glu Cys Arg 
    370                 375                 380                 


Tyr Ser Pro Lys Thr Lys Arg Ser Pro Leu Thr Arg Ala His Leu Thr 
385                 390                 395                 400 


Glu Val Glu Ser Arg Leu Glu Arg Leu Glu Gln Leu Phe Leu Leu Ile 
                405                 410                 415     


Phe Pro Arg Glu Asp Leu Asp Met Ile Leu Lys Met Asp Ser Leu Gln 
            420                 425                 430         


Asp Ile Lys Ala Leu Leu Thr Gly Leu Phe Val Gln Asp Asn Val Asn 
        435                 440                 445             


Lys Asp Ala Val Thr Asp Arg Leu Ala Ser Val Glu Thr Asp Met Pro 
    450                 455                 460                 


Leu Thr Leu Arg Gln His Arg Ile Ser Ala Thr Ser Ser Ser Glu Glu 
465                 470                 475                 480 


Ser Ser Asn Lys Gly Gln Arg Gln Leu Thr Val Ser Ala Ala Ala Gly 
                485                 490                 495     


Gly Ser Gly Gly Ser Gly Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu 
            500                 505                 510         


Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu 
        515                 520                 525             


Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp 
    530                 535                 540                 


Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser 
545                 550                 555     


<210>  53
<211>  557
<212>  PRT
<213>  GPC3- synEphrinB2EC-APLP2TM

<400>  53

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Glu Val Gln Leu Val Gln 
1               5                   10                  15      


Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys 
            20                  25                  30          


Lys Ala Ser Gly Tyr Thr Phe Ser Asp Tyr Glu Met His Trp Val Arg 
        35                  40                  45              


Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Ala Ile His Pro Gly 
    50                  55                  60                  


Ser Gly Asp Thr Ala Tyr Asn Gln Arg Phe Lys Gly Arg Val Thr Ile 
65                  70                  75                  80  


Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu 
                85                  90                  95      


Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Phe Tyr Ser Tyr 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met 
    130                 135                 140                 


Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly Glu Pro Ala Ser 
145                 150                 155                 160 


Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr 
                165                 170                 175     


Tyr Leu Gln Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu 
            180                 185                 190         


Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser 
        195                 200                 205             


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu 
    210                 215                 220                 


Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Ser Ile Tyr Val Pro 
225                 230                 235                 240 


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Gly Gln Asp 
                245                 250                 255     


Ala Ser Ser Ala Gly Ser Thr Arg Asn Lys Asp Pro Thr Arg Arg Pro 
            260                 265                 270         


Glu Leu Glu Ala Gly Thr Asn Gly Arg Ser Ser Thr Thr Ser Pro Phe 
        275                 280                 285             


Val Lys Pro Asn Pro Gly Ser Ser Thr Asp Gly Asn Ser Ala Gly His 
    290                 295                 300                 


Ser Gly Asn Asn Ile Leu Gly Ser Glu Val Ala Leu Phe Ala Ser Ala 
305                 310                 315                 320 


Leu Ile Gly Leu Leu Val Ile Ala Val Ala Ile Ala Thr Val Ile Val 
                325                 330                 335     


Ile Ser Leu Val Met Leu Arg Lys Arg Gln Met Lys Leu Leu Ser Ser 
            340                 345                 350         


Ile Glu Gln Ala Cys Asp Ile Cys Arg Leu Lys Lys Leu Lys Cys Ser 
        355                 360                 365             


Lys Glu Lys Pro Lys Cys Ala Lys Cys Leu Lys Asn Asn Trp Glu Cys 
    370                 375                 380                 


Arg Tyr Ser Pro Lys Thr Lys Arg Ser Pro Leu Thr Arg Ala His Leu 
385                 390                 395                 400 


Thr Glu Val Glu Ser Arg Leu Glu Arg Leu Glu Gln Leu Phe Leu Leu 
                405                 410                 415     


Ile Phe Pro Arg Glu Asp Leu Asp Met Ile Leu Lys Met Asp Ser Leu 
            420                 425                 430         


Gln Asp Ile Lys Ala Leu Leu Thr Gly Leu Phe Val Gln Asp Asn Val 
        435                 440                 445             


Asn Lys Asp Ala Val Thr Asp Arg Leu Ala Ser Val Glu Thr Asp Met 
    450                 455                 460                 


Pro Leu Thr Leu Arg Gln His Arg Ile Ser Ala Thr Ser Ser Ser Glu 
465                 470                 475                 480 


Glu Ser Ser Asn Lys Gly Gln Arg Gln Leu Thr Val Ser Ala Ala Ala 
                485                 490                 495     


Gly Gly Ser Gly Gly Ser Gly Gly Ser Asp Ala Leu Asp Asp Phe Asp 
            500                 505                 510         


Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met 
        515                 520                 525             


Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser 
    530                 535                 540                 


Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser 
545                 550                 555         


<210>  54
<211>  545
<212>  PRT
<213>  GPC3-synEphrinB2EC-del1

<400>  54

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Glu Val Gln Leu Val Gln 
1               5                   10                  15      


Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys 
            20                  25                  30          


Lys Ala Ser Gly Tyr Thr Phe Ser Asp Tyr Glu Met His Trp Val Arg 
        35                  40                  45              


Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Ala Ile His Pro Gly 
    50                  55                  60                  


Ser Gly Asp Thr Ala Tyr Asn Gln Arg Phe Lys Gly Arg Val Thr Ile 
65                  70                  75                  80  


Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu 
                85                  90                  95      


Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Phe Tyr Ser Tyr 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met 
    130                 135                 140                 


Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly Glu Pro Ala Ser 
145                 150                 155                 160 


Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr 
                165                 170                 175     


Tyr Leu Gln Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu 
            180                 185                 190         


Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser 
        195                 200                 205             


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu 
    210                 215                 220                 


Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Ser Ile Tyr Val Pro 
225                 230                 235                 240 


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Gly Gln Asp 
                245                 250                 255     


Ala Thr Arg Arg Pro Glu Leu Glu Ala Gly Thr Asn Gly Arg Ser Ser 
            260                 265                 270         


Thr Thr Ser Pro Phe Val Lys Pro Asn Pro Gly Ser Ser Thr Asp Gly 
        275                 280                 285             


Asn Ser Ala Gly His Ser Gly Asn Asn Ile Leu Gly Ser Glu Val Ala 
    290                 295                 300                 


Leu Phe Ala Leu Met Tyr Val Ala Ala Ala Ala Phe Val Leu Leu Phe 
305                 310                 315                 320 


Phe Val Gly Cys Gly Val Leu Leu Ser Arg Lys Arg Arg Arg Met Lys 
                325                 330                 335     


Leu Leu Ser Ser Ile Glu Gln Ala Cys Asp Ile Cys Arg Leu Lys Lys 
            340                 345                 350         


Leu Lys Cys Ser Lys Glu Lys Pro Lys Cys Ala Lys Cys Leu Lys Asn 
        355                 360                 365             


Asn Trp Glu Cys Arg Tyr Ser Pro Lys Thr Lys Arg Ser Pro Leu Thr 
    370                 375                 380                 


Arg Ala His Leu Thr Glu Val Glu Ser Arg Leu Glu Arg Leu Glu Gln 
385                 390                 395                 400 


Leu Phe Leu Leu Ile Phe Pro Arg Glu Asp Leu Asp Met Ile Leu Lys 
                405                 410                 415     


Met Asp Ser Leu Gln Asp Ile Lys Ala Leu Leu Thr Gly Leu Phe Val 
            420                 425                 430         


Gln Asp Asn Val Asn Lys Asp Ala Val Thr Asp Arg Leu Ala Ser Val 
        435                 440                 445             


Glu Thr Asp Met Pro Leu Thr Leu Arg Gln His Arg Ile Ser Ala Thr 
    450                 455                 460                 


Ser Ser Ser Glu Glu Ser Ser Asn Lys Gly Gln Arg Gln Leu Thr Val 
465                 470                 475                 480 


Ser Ala Ala Ala Gly Gly Ser Gly Gly Ser Gly Gly Ser Asp Ala Leu 
                485                 490                 495     


Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe 
            500                 505                 510         


Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp 
        515                 520                 525             


Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly 
    530                 535                 540                 


Ser 
545 


<210>  55
<211>  543
<212>  PRT
<213>  GPC3-synEphrinB2EC-del2

<400>  55

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Glu Val Gln Leu Val Gln 
1               5                   10                  15      


Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys 
            20                  25                  30          


Lys Ala Ser Gly Tyr Thr Phe Ser Asp Tyr Glu Met His Trp Val Arg 
        35                  40                  45              


Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Ala Ile His Pro Gly 
    50                  55                  60                  


Ser Gly Asp Thr Ala Tyr Asn Gln Arg Phe Lys Gly Arg Val Thr Ile 
65                  70                  75                  80  


Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu 
                85                  90                  95      


Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Phe Tyr Ser Tyr 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met 
    130                 135                 140                 


Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly Glu Pro Ala Ser 
145                 150                 155                 160 


Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr 
                165                 170                 175     


Tyr Leu Gln Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu 
            180                 185                 190         


Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser 
        195                 200                 205             


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu 
    210                 215                 220                 


Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Ser Ile Tyr Val Pro 
225                 230                 235                 240 


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Gly Gln Asp 
                245                 250                 255     


Ala Ser Ser Ala Gly Ser Thr Arg Asn Lys Asp Pro Thr Arg Arg Pro 
            260                 265                 270         


Ser Pro Phe Val Lys Pro Asn Pro Gly Ser Ser Thr Asp Gly Asn Ser 
        275                 280                 285             


Ala Gly His Ser Gly Asn Asn Ile Leu Gly Ser Glu Val Ala Leu Phe 
    290                 295                 300                 


Ala Leu Met Tyr Val Ala Ala Ala Ala Phe Val Leu Leu Phe Phe Val 
305                 310                 315                 320 


Gly Cys Gly Val Leu Leu Ser Arg Lys Arg Arg Arg Met Lys Leu Leu 
                325                 330                 335     


Ser Ser Ile Glu Gln Ala Cys Asp Ile Cys Arg Leu Lys Lys Leu Lys 
            340                 345                 350         


Cys Ser Lys Glu Lys Pro Lys Cys Ala Lys Cys Leu Lys Asn Asn Trp 
        355                 360                 365             


Glu Cys Arg Tyr Ser Pro Lys Thr Lys Arg Ser Pro Leu Thr Arg Ala 
    370                 375                 380                 


His Leu Thr Glu Val Glu Ser Arg Leu Glu Arg Leu Glu Gln Leu Phe 
385                 390                 395                 400 


Leu Leu Ile Phe Pro Arg Glu Asp Leu Asp Met Ile Leu Lys Met Asp 
                405                 410                 415     


Ser Leu Gln Asp Ile Lys Ala Leu Leu Thr Gly Leu Phe Val Gln Asp 
            420                 425                 430         


Asn Val Asn Lys Asp Ala Val Thr Asp Arg Leu Ala Ser Val Glu Thr 
        435                 440                 445             


Asp Met Pro Leu Thr Leu Arg Gln His Arg Ile Ser Ala Thr Ser Ser 
    450                 455                 460                 


Ser Glu Glu Ser Ser Asn Lys Gly Gln Arg Gln Leu Thr Val Ser Ala 
465                 470                 475                 480 


Ala Ala Gly Gly Ser Gly Gly Ser Gly Gly Ser Asp Ala Leu Asp Asp 
                485                 490                 495     


Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu 
            500                 505                 510         


Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu 
        515                 520                 525             


Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser 
    530                 535                 540             


<210>  56
<211>  532
<212>  PRT
<213>  GPC3-synEphrinB2EC-del3

<400>  56

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Glu Val Gln Leu Val Gln 
1               5                   10                  15      


Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys 
            20                  25                  30          


Lys Ala Ser Gly Tyr Thr Phe Ser Asp Tyr Glu Met His Trp Val Arg 
        35                  40                  45              


Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Ala Ile His Pro Gly 
    50                  55                  60                  


Ser Gly Asp Thr Ala Tyr Asn Gln Arg Phe Lys Gly Arg Val Thr Ile 
65                  70                  75                  80  


Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu 
                85                  90                  95      


Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Phe Tyr Ser Tyr 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met 
    130                 135                 140                 


Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly Glu Pro Ala Ser 
145                 150                 155                 160 


Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr 
                165                 170                 175     


Tyr Leu Gln Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu 
            180                 185                 190         


Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser 
        195                 200                 205             


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu 
    210                 215                 220                 


Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Ser Ile Tyr Val Pro 
225                 230                 235                 240 


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Gly Gln Asp 
                245                 250                 255     


Ala Ser Ser Ala Gly Ser Thr Arg Asn Lys Asp Pro Thr Arg Arg Pro 
            260                 265                 270         


Glu Leu Glu Ala Gly Thr Asn Gly Arg Ser Ser Thr Thr Ser Pro Ser 
        275                 280                 285             


Glu Val Ala Leu Phe Ala Leu Met Tyr Val Ala Ala Ala Ala Phe Val 
    290                 295                 300                 


Leu Leu Phe Phe Val Gly Cys Gly Val Leu Leu Ser Arg Lys Arg Arg 
305                 310                 315                 320 


Arg Met Lys Leu Leu Ser Ser Ile Glu Gln Ala Cys Asp Ile Cys Arg 
                325                 330                 335     


Leu Lys Lys Leu Lys Cys Ser Lys Glu Lys Pro Lys Cys Ala Lys Cys 
            340                 345                 350         


Leu Lys Asn Asn Trp Glu Cys Arg Tyr Ser Pro Lys Thr Lys Arg Ser 
        355                 360                 365             


Pro Leu Thr Arg Ala His Leu Thr Glu Val Glu Ser Arg Leu Glu Arg 
    370                 375                 380                 


Leu Glu Gln Leu Phe Leu Leu Ile Phe Pro Arg Glu Asp Leu Asp Met 
385                 390                 395                 400 


Ile Leu Lys Met Asp Ser Leu Gln Asp Ile Lys Ala Leu Leu Thr Gly 
                405                 410                 415     


Leu Phe Val Gln Asp Asn Val Asn Lys Asp Ala Val Thr Asp Arg Leu 
            420                 425                 430         


Ala Ser Val Glu Thr Asp Met Pro Leu Thr Leu Arg Gln His Arg Ile 
        435                 440                 445             


Ser Ala Thr Ser Ser Ser Glu Glu Ser Ser Asn Lys Gly Gln Arg Gln 
    450                 455                 460                 


Leu Thr Val Ser Ala Ala Ala Gly Gly Ser Gly Gly Ser Gly Gly Ser 
465                 470                 475                 480 


Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu 
                485                 490                 495     


Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe 
            500                 505                 510         


Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp 
        515                 520                 525             


Met Leu Gly Ser 
    530         


<210>  57
<211>  517
<212>  PRT
<213>  GPC3-synEphrinB2EC-del23

<400>  57

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Glu Val Gln Leu Val Gln 
1               5                   10                  15      


Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys 
            20                  25                  30          


Lys Ala Ser Gly Tyr Thr Phe Ser Asp Tyr Glu Met His Trp Val Arg 
        35                  40                  45              


Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Ala Ile His Pro Gly 
    50                  55                  60                  


Ser Gly Asp Thr Ala Tyr Asn Gln Arg Phe Lys Gly Arg Val Thr Ile 
65                  70                  75                  80  


Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu 
                85                  90                  95      


Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Phe Tyr Ser Tyr 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met 
    130                 135                 140                 


Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly Glu Pro Ala Ser 
145                 150                 155                 160 


Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr 
                165                 170                 175     


Tyr Leu Gln Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu 
            180                 185                 190         


Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser 
        195                 200                 205             


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu 
    210                 215                 220                 


Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Ser Ile Tyr Val Pro 
225                 230                 235                 240 


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Gly Gln Asp 
                245                 250                 255     


Ala Ser Ser Ala Gly Ser Thr Arg Asn Lys Asp Pro Thr Arg Arg Pro 
            260                 265                 270         


Ser Glu Val Ala Leu Phe Ala Leu Met Tyr Val Ala Ala Ala Ala Phe 
        275                 280                 285             


Val Leu Leu Phe Phe Val Gly Cys Gly Val Leu Leu Ser Arg Lys Arg 
    290                 295                 300                 


Arg Arg Met Lys Leu Leu Ser Ser Ile Glu Gln Ala Cys Asp Ile Cys 
305                 310                 315                 320 


Arg Leu Lys Lys Leu Lys Cys Ser Lys Glu Lys Pro Lys Cys Ala Lys 
                325                 330                 335     


Cys Leu Lys Asn Asn Trp Glu Cys Arg Tyr Ser Pro Lys Thr Lys Arg 
            340                 345                 350         


Ser Pro Leu Thr Arg Ala His Leu Thr Glu Val Glu Ser Arg Leu Glu 
        355                 360                 365             


Arg Leu Glu Gln Leu Phe Leu Leu Ile Phe Pro Arg Glu Asp Leu Asp 
    370                 375                 380                 


Met Ile Leu Lys Met Asp Ser Leu Gln Asp Ile Lys Ala Leu Leu Thr 
385                 390                 395                 400 


Gly Leu Phe Val Gln Asp Asn Val Asn Lys Asp Ala Val Thr Asp Arg 
                405                 410                 415     


Leu Ala Ser Val Glu Thr Asp Met Pro Leu Thr Leu Arg Gln His Arg 
            420                 425                 430         


Ile Ser Ala Thr Ser Ser Ser Glu Glu Ser Ser Asn Lys Gly Gln Arg 
        435                 440                 445             


Gln Leu Thr Val Ser Ala Ala Ala Gly Gly Ser Gly Gly Ser Gly Gly 
    450                 455                 460                 


Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala 
465                 470                 475                 480 


Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp 
                485                 490                 495     


Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu 
            500                 505                 510         


Asp Met Leu Gly Ser 
        515         


<210>  58
<211>  540
<212>  PRT
<213>  IL12ǻP35P40

<400>  58

Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 
1               5                   10                  15      


Ala Ser Pro Leu Val Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln 
    50                  55                  60                  


Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys 
65                  70                  75                  80  


Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val 
                85                  90                  95      


Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp 
            100                 105                 110         


Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe 
        115                 120                 125             


Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp 
    130                 135                 140                 


Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser 
                165                 170                 175     


Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu 
            180                 185                 190         


Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile 
        195                 200                 205             


Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr 
    210                 215                 220                 


Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn 
225                 230                 235                 240 


Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp 
                245                 250                 255     


Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr 
            260                 265                 270         


Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg 
        275                 280                 285             


Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala 
    290                 295                 300                 


Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser 
305                 310                 315                 320 


Glu Trp Ala Ser Val Pro Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                325                 330                 335     


Gly Ser Gly Gly Gly Gly Ser Arg Asn Leu Pro Val Ala Thr Pro Asp 
            340                 345                 350         


Pro Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala 
        355                 360                 365             


Val Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro 
    370                 375                 380                 


Cys Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr 
385                 390                 395                 400 


Ser Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser 
                405                 410                 415     


Cys Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu 
            420                 425                 430         


Ala Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile 
        435                 440                 445             


Tyr Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala 
    450                 455                 460                 


Lys Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met 
465                 470                 475                 480 


Leu Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu 
                485                 490                 495     


Thr Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr 
            500                 505                 510         


Lys Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val 
        515                 520                 525             


Thr Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser 
    530                 535                 540 


<210>  59
<211>  3921
<212>  DNA
<213>  IL12-GPC3-synEphrinB2EC-del3

<400>  59
aagcttgata tcgaattcgg agcactgtcc tccgaacgtc ggagcactgt cctccgaacg       60

tcggagcact gtcctccgaa cgtcggagca ctgtcctccg aacggagcat gtcctccgaa      120

cgtcggagca ctgtcctccg aacgactagt taggcgtgta cggtgggagg cctatataag      180

cagagctcgt ttagtgaacc gtcagatcgc ctggagacgc catccacgct gttttgacct      240

ccatagaaga caccgggacc gatccagcct ctcgacattc gttggatcat gtgtcaccag      300

cagttggtca tctcttggtt ttccctggtt tttctggcat ctcccctcgt ggccatatgg      360

gaactgaaga aagatgttta tgtcgtagaa ttggattggt atccggatgc ccctggagaa      420

atggtggtcc tcacctgtga cacccctgaa gaagatggta tcacctggac cttggaccag      480

agcagtgagg tcttaggctc tggcaaaacc ctgaccatcc aagtcaaaga gtttggagat      540

gctggccagt acacctgtca caaaggaggc gaggttctaa gccattcgct cctgctgctt      600

cacaaaaagg aagatggaat ttggtccact gatattttaa aggaccagaa agaacccaaa      660

aataagacct ttctaagatg cgaggccaag aattattctg gacgtttcac ctgctggtgg      720

ctgacgacaa tcagtactga tttgacattc agtgtcaaaa gcagcagagg ctcttctgac      780

ccccaagggg tgacgtgcgg agctgctaca ctctctgcag agagagtcag aggggacaac      840

aaggagtatg agtactcagt ggagtgccag gaggacagtg cctgcccagc tgctgaggag      900

agtctgccca ttgaggtcat ggtggatgcc gttcacaagc tcaagtatga aaactacacc      960

agcagcttct tcatcaggga catcatcaaa cctgacccac ccaagaactt gcagctgaag     1020

ccattaaaga attctcggca ggtggaggtc agctgggagt accctgacac ctggagtact     1080

ccacattcct acttctccct gacattctgc gttcaggtcc agggcaagag caagagagaa     1140

aagaaagata gagtcttcac ggacaagacc tcagccacgg tcatctgccg caaaaatgcc     1200

agcattagcg tgcgggccca ggaccgctac tatagctcat cttggagcga atgggcatct     1260

gtgccctgca gtggtggcgg tggctcgggc ggtggtgggt cgggtggcgg cggatctaga     1320

aacctccccg tggccactcc agacccagga atgttcccat gccttcacca ctcccaaaac     1380

ctgctgaggg ccgtcagcaa catgctccag aaggccagac aaactctaga attttaccct     1440

tgcacttctg aagagattga tcatgaagat atcacaaaag ataaaaccag cacagtggag     1500

gcctgtttac cattggaatt aaccaagaat gagagttgcc taaattccag agagacctct     1560

ttcataacta atgggagttg cctggcctcc agaaagacct cttttatgat ggccctgtgc     1620

cttagtagta tttatgaaga cttgaagatg taccaggtgg agttcaagac catgaatgca     1680

aagcttctga tggatcctaa gaggcagatc tttctagatc aaaacatgct ggcagttatt     1740

gatgagctga tgcaggccct gaatttcaac agtgagactg tgccacaaaa atcctccctt     1800

gaagaaccgg atttttataa aactaaaatc aagctctgca tacttcttca tgctttcaga     1860

attcgggcag tgactattga tagagtgatg agctatctga atgcttccta aacgcgtggc     1920

tccggtgccc gtcagtgggc agagcgcaca tcgcccacag tccccgagaa gttgggggga     1980

ggggtcggca attgaaccgg tgcctagaga aggtggcgcg gggtaaactg ggaaagtgat     2040

gtcgtgtact ggctccgcct ttttcccgag ggtgggggag aaccgtatat aagtgcagta     2100

gtcgccgtga acgttctttt tcgcaacggg tttgccgcca gaacacaggt gtcgtgacgc     2160

ggatccaggc ctaagcttac gcgtgccacc atggcgctcc ctgtcaccgc actgcttctt     2220

ccgctggcac tgctgctgca cgctgcacgg cctgagcaaa aacttatctc tgaagaggac     2280

ctcgaggtgc agctggtgca gagcggcgcc gaggtgaaga agcccggcgc cagcgtgaag     2340

gtgagctgca aggccagcgg ctacaccttc agcgactacg agatgcactg ggtgcggcag     2400

gcccccggcc agggcctgga gtggatgggc gccatccacc ccggcagcgg cgacaccgcc     2460

tacaaccagc ggttcaaggg ccgggtgacc atcaccgccg acaagagcac cagcaccgcc     2520

tacatggagc tgagcagcct gcggagcgag gacaccgccg tgtactactg cgcccggttc     2580

tacagctacg cctactgggg ccagggcacc ctggtgaccg tgagcgccgg tggaggcggt     2640

tcaggcggag gtggttctgg cggtggcgga tcggacatcg tgatgaccca gacccccctg     2700

agcctgcccg tgacccccgg cgagcccgcc agcatcagct gccggagcag ccagagcctg     2760

gtgcacagca acggcaacac ctacctgcag tggtacctgc agaagcccgg ccagagcccc     2820

cagctgctga tctacaaggt gagcaaccgg ttcagcggcg tgcccgaccg gttcagcggc     2880

agcggcagcg gcaccgactt caccctgaag atcagccggg tggaggccga ggacgtgggc     2940

gtgtactact gcagccagag catctacgtg ccctacacct tcggccaggg caccaagctg     3000

gagatcaaac gtggacaaga tgcaagttct gctggatcaa ccaggaataa agatccaaca     3060

agacgtccag aactagaagc tggtacaaat ggaagaagtt cgacaacaag tccctttgta     3120

aaaccaaatc caggttctag cacagacggc aacagcgccg gacattcggg gaacaacatc     3180

ctcggttccg aagtggcctt atttgcactc atgtacgtgg cagcggccgc cttcgtgctc     3240

ctgttctttg tgggctgtgg ggtgctgctg tcccgcaagc gccggcggat gaagctgctg     3300

agcagcatcg agcaggcctg tgacatctgc cggctgaaga aactgaagtg cagcaaagaa     3360

aagcccaagt gcgccaagtg cctgaagaac aactgggagt gccggtacag ccccaagacc     3420

aagagaagcc ccctgaccag agcccacctg accgaggtgg aaagccggct ggaaagactg     3480

gaacagctgt ttctgctgat cttcccacgc gaggacctgg acatgatcct gaagatggac     3540

agcctgcagg acatcaaggc cctgctgacc ggcctgttcg tgcaggacaa cgtgaacaag     3600

gacgccgtga ccgacagact ggccagcgtg gaaaccgaca tgcccctgac cctgcggcag     3660

cacagaatca gcgccaccag cagcagcgag gaaagcagca acaagggcca gcggcagctg     3720

acagtgtctg ctgctgcagg cggaagcgga ggctctggcg gatctgatgc cctggacgac     3780

ttcgacctgg atatgctggg cagcgacgcc ctggatgatt ttgatctgga catgctggga     3840

tctgacgctc tggacgattt cgatctcgac atgttgggat cagatgcact ggatgacttt     3900

gacctggaca tgctcggatc a                                               3921


<210>  60
<211>  467
<212>  PRT
<213>  GPC3-CAR

<400>  60

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ala Ile His Pro Gly Ser Gly Asp Thr Ala Tyr Asn Gln Arg Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Ser Tyr Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr 
    130                 135                 140                 


Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val 
145                 150                 155                 160 


His Ser Asn Gly Asn Thr Tyr Leu Gln Trp Tyr Leu Gln Lys Pro Gly 
                165                 170                 175     


Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly 
            180                 185                 190         


Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser 
    210                 215                 220                 


Gln Ser Ile Tyr Val Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu 
225                 230                 235                 240 


Ile Lys Arg Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
                245                 250                 255     


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
            260                 265                 270         


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        275                 280                 285             


Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
    290                 295                 300                 


Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu 
305                 310                 315                 320 


Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
                325                 330                 335     


Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
            340                 345                 350         


Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln 
        355                 360                 365             


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
    370                 375                 380                 


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
385                 390                 395                 400 


Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
                405                 410                 415     


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
            420                 425                 430         


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
        435                 440                 445             


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
    450                 455                 460                 


Pro Pro Arg 
465         


<210>  61
<211>  542
<212>  PRT
<213>  EGFRv-EphrinB2EC

<400>  61

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys His Ala Ser Gln Asp Ile Asn Val Asn 
            20                  25                  30          


Ile Gly Trp Leu Gln Gln Lys Pro Gly Lys Ala Phe Lys Gly Leu Ile 
        35                  40                  45              


Tyr His Gly Lys Asn Leu Glu Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Asn Gln Tyr Glu Asn Ile Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Gln Leu Val 
        115                 120                 125             


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
    130                 135                 140                 


Cys Ala Val Ser Gly Tyr Ser Ile Thr Ser Asp Tyr Ala Trp Asn Trp 
145                 150                 155                 160 


Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu Gly Tyr Ile Ser 
                165                 170                 175     


Tyr Arg Gly Arg Thr Gln Tyr Asn Pro Ser Leu Lys Ser Arg Ile Ser 
            180                 185                 190         


Ile Thr Arg Asp Asn Ser Lys Asn Thr Phe Phe Leu Gln Leu Asn Ser 
        195                 200                 205             


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Met Gly Lys 
    210                 215                 220                 


Asn Trp Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
225                 230                 235                 240 


Gln Asp Ala Ser Ser Ala Gly Ser Thr Arg Asn Lys Asp Pro Thr Arg 
                245                 250                 255     


Arg Pro Glu Leu Glu Ala Gly Thr Asn Gly Arg Ser Ser Thr Thr Ser 
            260                 265                 270         


Pro Phe Val Lys Pro Asn Pro Gly Ser Ser Thr Asp Gly Asn Ser Ala 
        275                 280                 285             


Gly His Ser Gly Asn Asn Ile Leu Gly Ser Glu Val Ala Leu Phe Ala 
    290                 295                 300                 


Leu Met Tyr Val Ala Ala Ala Ala Phe Val Leu Leu Phe Phe Val Gly 
305                 310                 315                 320 


Cys Gly Val Leu Leu Ser Arg Lys Arg Arg Arg Met Lys Leu Leu Ser 
                325                 330                 335     


Ser Ile Glu Gln Ala Cys Asp Ile Cys Arg Leu Lys Lys Leu Lys Cys 
            340                 345                 350         


Ser Lys Glu Lys Pro Lys Cys Ala Lys Cys Leu Lys Asn Asn Trp Glu 
        355                 360                 365             


Cys Arg Tyr Ser Pro Lys Thr Lys Arg Ser Pro Leu Thr Arg Ala His 
    370                 375                 380                 


Leu Thr Glu Val Glu Ser Arg Leu Glu Arg Leu Glu Gln Leu Phe Leu 
385                 390                 395                 400 


Leu Ile Phe Pro Arg Glu Asp Leu Asp Met Ile Leu Lys Met Asp Ser 
                405                 410                 415     


Leu Gln Asp Ile Lys Ala Leu Leu Thr Gly Leu Phe Val Gln Asp Asn 
            420                 425                 430         


Val Asn Lys Asp Ala Val Thr Asp Arg Leu Ala Ser Val Glu Thr Asp 
        435                 440                 445             


Met Pro Leu Thr Leu Arg Gln His Arg Ile Ser Ala Thr Ser Ser Ser 
    450                 455                 460                 


Glu Glu Ser Ser Asn Lys Gly Gln Arg Gln Leu Thr Val Ser Ala Ala 
465                 470                 475                 480 


Ala Gly Gly Ser Gly Gly Ser Gly Gly Ser Asp Ala Leu Asp Asp Phe 
                485                 490                 495     


Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp 
            500                 505                 510         


Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly 
        515                 520                 525             


Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser 
    530                 535                 540         


<210>  62
<211>  471
<212>  PRT
<213>  IL13Ra2-CAR

<400>  62

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Lys Tyr 
            20                  25                  30          


Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Gly Ser Val Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Arg Tyr Gly Trp Gly Ala Gly Ala Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
    130                 135                 140                 


Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Gln Ser Ile Ser Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu Glu Ser 
            180                 185                 190         


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Tyr Asp Thr Tyr Pro Pro Ile Thr Phe Gly Gln Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys Arg Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
                245                 250                 255     


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
            260                 265                 270         


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
        275                 280                 285             


Cys Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr 
    290                 295                 300                 


Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys 
305                 310                 315                 320 


Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg 
                325                 330                 335     


Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp 
            340                 345                 350         


Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
        355                 360                 365             


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
    370                 375                 380                 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
385                 390                 395                 400 


Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly 
                405                 410                 415     


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
            420                 425                 430         


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
        435                 440                 445             


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
    450                 455                 460                 


Met Gln Ala Leu Pro Pro Arg 
465                 470     


<210>  63
<211>  3735
<212>  DNA
<213>  EGFRv-EphrinB2EC-IL13Ra2-CAR

<400>  63
aagcttgata tcgaattcgg agcactgtcc tccgaacgtc ggagcactgt cctccgaacg       60

tcggagcact gtcctccgaa cgtcggagca ctgtcctccg aacggagcat gtcctccgaa      120

cgtcggagca ctgtcctccg aacgactagt taggcgtgta cggtgggagg cctatataag      180

cagagctcgt ttagtgaacc gtcagatcgc ctggagacgc catccacgct gttttgacct      240

ccatagaaga caccgggacc gatccagcct ctcgacattc gttggatcat ggccttacca      300

gtgaccgcct tgctcctgcc gctggccttg ctgctccacg ccgccaggcc ggaggtgcaa      360

ttgctggagt ctgggggagg cttggtacag cctggggggt ccctgagact ctcctgtgca      420

gcctccggat tcacctttcg caagtatgcc atgggctggg tccgccaggc tccagggaag      480

gggctggagt gggtctcagg tattagtggt agtgttggta gcacatacta cgcagactcc      540

gtgaagggcc ggttcaccat ctccagagac aattccaaga acacgctgta tctgcagatg      600

aacagcctga gagccgagga cacggccgta tattactgtg cgaaagttcg ttacggttgg      660

ggtgcaggtg cattcgacta ctggggccaa ggaaccctgg tcaccgtctc gagtggtgga      720

ggcggttcag gcggaggtgg ttctggcggt ggcggatcgg acatccagat gacccagtct      780

ccttccaccc tgtctgcatc tgtaggagac cgtgtcacca tcacttgccg tgccagtcag      840

agtattagta gctggttggc ctggtatcag cagaaaccag ggaaagcccc taagctcctg      900

atctatgatg cctccagttt ggaaagtggg gtcccatcac gtttcagcgg cagtggatcc      960

gggacagaat tcactctcac catcagcagc ttgcagcctg atgattttgc aacttattac     1020

tgccaacagt acgataccta cccaccaatc acgtttggcc agggcaccaa agtcgagatc     1080

aagcgtacca cgacgccagc gccgcgacca ccaacaccgg cgcccaccat cgcgtcgcag     1140

cccctgtccc tgcgcccaga ggcgtgccgg ccagcggcgg ggggcgcagt gcacacgagg     1200

gggctggact tcgcctgtga tttttgggtg ctggtggtgg ttggtggagt cctggcttgc     1260

tatagcttgc tagtaacagt ggcctttatt attttctggg tgaggagtaa gaggagcagg     1320

ctcctgcaca gtgactacat gaacatgact ccccgccgcc ccgggccaac ccgcaagcat     1380

taccagccct atgccccacc acgcgacttc gcagcctatc gctccagagt gaagttcagc     1440

aggagcgcag acgcccccgc gtaccagcag ggccagaacc agctctataa cgagctcaat     1500

ctaggacgaa gagaggagta cgatgttttg gacaagagac gtggccggga ccctgagatg     1560

gggggaaagc cgcagagaag gaagaaccct caggaaggcc tgtacaatga actgcagaaa     1620

gataagatgg cggaggccta cagtgagatt gggatgaaag gcgagcgccg gaggggcaag     1680

gggcacgatg gcctttacca gggtctcagt acagccacca aggacaccta cgacgccctt     1740

cacatgcagg ccctgccccc tcgctagacg cgtggctccg gtgcccgtca gtgggcagag     1800

cgcacatcgc ccacagtccc cgagaagttg gggggagggg tcggcaattg aaccggtgcc     1860

tagagaaggt ggcgcggggt aaactgggaa agtgatgtcg tgtactggct ccgccttttt     1920

cccgagggtg ggggagaacc gtatataagt gcagtagtcg ccgtgaacgt tctttttcgc     1980

aacgggtttg ccgccagaac acaggtgtcg tgacgcggat ccaggcctaa gcttacgcgt     2040

gccaccatgg ccttaccagt gaccgccttg ctcctgccgc tggccttgct gctccacgcc     2100

gccaggccgg atattcagat gacccagagc ccgagcagcc tgagcgcgag cgtgggcgac     2160

cgtgtgacca ttacctgcca tgcgagccag gatattaacg tgaacattgg ctggctgcag     2220

cagaaaccgg gcaaagcgtt taaaggcctg atttatcatg gcaaaaacct ggaagatggc     2280

gtgccgagcc gttttagcgg cagcggcagc ggcaccgatt ttaccctgac cattagcagc     2340

ctgcagccgg aagattttgc gacctattat tgcaatcagt atgaaaatat cccactgaca     2400

tttggccagg gcaccaaagt ggaaattaaa cgtggtggag gcggttcagg cggaggtggc     2460

tctggcggtg gcggatcgga tgtgcagctg gtggaaagcg gcggcggcct ggtgcagccg     2520

ggcggcagcc tgcgtctgag ctgcgcggtg agcggctata gcattaccag cgattatgcg     2580

tggaactgga ttcgtcaggc gccgggcaaa ggcctggaat ggctgggcta tattagctat     2640

cgtggccgca cccagtataa cccgagcctg aaaagccgta ttagcattac ccgtgataac     2700

agcaaaaaca cctttttcct gcagctgaac agcctgcgtg cggaagatac cgcggtgtat     2760

tattgcgcgc gcatgggtaa gaattgggat tactggggcc agggcaccct ggtgaccgtg     2820

agcagcggac aagatgcaag ttctgctgga tcaaccagga ataaagatcc aacaagacgt     2880

ccagaactag aagctggtac aaatggaaga agttcgacaa caagtccctt tgtaaaacca     2940

aatccaggtt ctagcacaga cggcaacagc gccggacatt cggggaacaa catcctcggt     3000

tccgaagtgg ccttatttgc actcatgtac gtggcagcgg ccgccttcgt gctcctgttc     3060

tttgtgggct gtggggtgct gctgtcccgc aagcgccggc ggatgaagct gctgagcagc     3120

atcgagcagg cctgtgacat ctgccggctg aagaaactga agtgcagcaa agaaaagccc     3180

aagtgcgcca agtgcctgaa gaacaactgg gagtgccggt acagccccaa gaccaagaga     3240

agccccctga ccagagccca cctgaccgag gtggaaagcc ggctggaaag actggaacag     3300

ctgtttctgc tgatcttccc acgcgaggac ctggacatga tcctgaagat ggacagcctg     3360

caggacatca aggccctgct gaccggcctg ttcgtgcagg acaacgtgaa caaggacgcc     3420

gtgaccgaca gactggccag cgtggaaacc gacatgcccc tgaccctgcg gcagcacaga     3480

atcagcgcca ccagcagcag cgaggaaagc agcaacaagg gccagcggca gctgacagtg     3540

tctgctgctg caggcggaag cggaggctct ggcggatctg atgccctgga cgacttcgac     3600

ctggatatgc tgggcagcga cgccctggat gattttgatc tggacatgct gggatctgac     3660

gctctggacg atttcgatct cgacatgttg ggatcagatg cactggatga ctttgacctg     3720

gacatgctcg gatca                                                      3735


<210>  64
<211>  467
<212>  PRT
<213>  B7H3-28Z

<400>  64

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Tyr Arg Ala Val Thr Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser 
    130                 135                 140                 


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser 
145                 150                 155                 160 


Ile Ser Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
                165                 170                 175     


Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser 
            180                 185                 190         


Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser 
        195                 200                 205             


Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Glu 
    210                 215                 220                 


Thr Gln Ile Arg Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
225                 230                 235                 240 


Arg Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
                245                 250                 255     


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
            260                 265                 270         


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe Trp 
        275                 280                 285             


Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val 
    290                 295                 300                 


Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu 
305                 310                 315                 320 


Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr 
                325                 330                 335     


Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr 
            340                 345                 350         


Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln 
        355                 360                 365             


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
    370                 375                 380                 


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
385                 390                 395                 400 


Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
                405                 410                 415     


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
            420                 425                 430         


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
        435                 440                 445             


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
    450                 455                 460                 


Pro Pro Arg 
465         


<210>  65
<211>  465
<212>  PRT
<213>  B7H3-BBZ

<400>  65

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Tyr Arg Ala Val Thr Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser 
    130                 135                 140                 


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser 
145                 150                 155                 160 


Ile Ser Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
                165                 170                 175     


Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser 
            180                 185                 190         


Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser 
        195                 200                 205             


Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Glu 
    210                 215                 220                 


Thr Gln Ile Arg Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
225                 230                 235                 240 


Arg Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
                245                 250                 255     


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
            260                 265                 270         


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
        275                 280                 285             


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
    290                 295                 300                 


Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
305                 310                 315                 320 


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
                325                 330                 335     


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
            340                 345                 350         


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
        355                 360                 365             


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
    370                 375                 380                 


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
385                 390                 395                 400 


Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
                405                 410                 415     


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
            420                 425                 430         


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
        435                 440                 445             


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
    450                 455                 460                 


Arg 
465 


<210>  66
<211>  466
<212>  PRT
<213>  376.96-28Z

<400>  66

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Ile Gly 
1               5                   10                  15      


Ala Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Arg Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln His Tyr Gly Thr Pro Pro 
                85                  90                  95      


Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
        115                 120                 125             


Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Lys Leu Ser 
    130                 135                 140                 


Cys Glu Ala Ser Arg Phe Thr Phe Ser Ser Tyr Ala Met Ser Trp Val 
145                 150                 155                 160 


Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val Ala Ala Ile Ser Gly 
                165                 170                 175     


Gly Gly Arg Tyr Thr Tyr Tyr Pro Asp Ser Met Lys Gly Arg Phe Thr 
            180                 185                 190         


Ile Ser Arg Asp Asn Ala Lys Asn Phe Leu Tyr Leu Gln Met Ser Ser 
        195                 200                 205             


Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg His Tyr Asp 
    210                 215                 220                 


Gly Tyr Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
225                 230                 235                 240 


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
                245                 250                 255     


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            260                 265                 270         


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe Trp Val 
        275                 280                 285             


Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr 
    290                 295                 300                 


Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu 
305                 310                 315                 320 


His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg 
                325                 330                 335     


Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg 
            340                 345                 350         


Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
        355                 360                 365             


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
    370                 375                 380                 


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
385                 390                 395                 400 


Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
                405                 410                 415     


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
            420                 425                 430         


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
        435                 440                 445             


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
    450                 455                 460                 


Pro Arg 
465     


<210>  67
<211>  471
<212>  PRT
<213>  Claudin18.2-CAR

<400>  67

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Ile Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Tyr Asn Trp His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile His Tyr Thr Gly Ser Thr Asn Tyr Asn Pro Ala Leu 
    50                  55                  60                  


Arg Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ile Tyr Asn Gly Asn Ser Phe Pro Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu 
    130                 135                 140                 


Ala Val Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln 
145                 150                 155                 160 


Ser Leu Phe Asn Ser Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr 
            180                 185                 190         


Arg Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Gln Asn Ala Tyr Ser Phe Pro Tyr Thr Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Leu Glu Ile Lys Arg Thr Thr Thr Pro Ala Pro Arg Pro Pro 
                245                 250                 255     


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
            260                 265                 270         


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
        275                 280                 285             


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
    290                 295                 300                 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
305                 310                 315                 320 


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
                325                 330                 335     


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
            340                 345                 350         


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
        355                 360                 365             


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
    370                 375                 380                 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
385                 390                 395                 400 


Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly 
                405                 410                 415     


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
            420                 425                 430         


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
        435                 440                 445             


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
    450                 455                 460                 


Met Gln Ala Leu Pro Pro Arg 
465                 470     


<210>  68
<211>  3766
<212>  DNA
<213>  Mesothelin-synEphrinB2EC- Claudin18.2-CAR

<400>  68
aagcttgata tcgaattcgg agcactgtcc tccgaacgtc ggagcactgt cctccgaacg       60

tcggagcact gtcctccgaa cgtcggagca ctgtcctccg aacggagcat gtcctccgaa      120

cgtcggagca ctgtcctccg aacgactagt taggcgtgta cggtgggagg cctatataag      180

cagagctcgt ttagtgaacc gtcagatcgc ctggagacgc catccacgct gttttgacct      240

ccatagaaga caccgggacc gatccagcct ctcgacattc gttggatcat ggccttacca      300

gtgaccgcct tgctcctgcc gctggccttg ctgctccacg ccgccaggcc gcaggtgcag      360

ctgcaggaga gcggccccgg cctgatcaag cccagccaga ccctgagcct gacctgcacc      420

gtgagcggcg gcagcatcag cagcggctac aactggcact ggatccggca gccccccggc      480

aagggcctgg agtggatcgg ctacatccac tacaccggca gcaccaacta caaccccgcc      540

ctgcggagcc gggtgaccat cagcgtggac accagcaaga accagttcag cctgaagctg      600

agcagcgtga ccgccgccga caccgccatc tactactgcg cccggatcta caacggcaac      660

agcttcccct actggggcca gggcaccacc gtgaccgtga gcagcggtgg aggcggttca      720

ggcggaggtg gttctggcgg tggcggatcg gacatcgtga tgacccagag ccccgacagc      780

ctggccgtga gcctgggcga gcgggccacc atcaactgca agagcagcca gagcctgttc      840

aacagcggca accagaagaa ctacctgacc tggtaccagc agaagcccgg ccagcccccc      900

aagctgctga tctactgggc cagcacccgg gagagcggcg tgcccgaccg gttcagcggc      960

agcggcagcg gcaccgactt caccctgacc atcagcagcc tgcaggccga ggacgtggcc     1020

gtgtactact gccagaacgc ctacagcttc ccctacacct tcggcggcgg caccaagctg     1080

gagatcaagc ggaccacgac gccagcgccg cgaccaccaa caccggcgcc caccatcgcg     1140

tcgcagcccc tgtccctgcg cccagaggcg tgccggccag cggcgggggg cgcagtgcac     1200

acgagggggc tggacttcgc ctgtgatatc tacatctggg cgcccttggc cgggacttgt     1260

ggggtccttc tcctgtcact ggttatcacc ctttactgca aacggggcag aaagaaactc     1320

ctgtatatat tcaaacaacc atttatgaga ccagtacaaa ctactcaaga ggaagatggc     1380

tgtagctgcc gatttccaga agaagaagaa ggaggatgtg aactgagagt gaagttcagc     1440

aggagcgcag acgcccccgc gtaccagcag ggccagaacc agctctataa cgagctcaat     1500

ctaggacgaa gagaggagta cgatgttttg gacaagagac gtggccggga ccctgagatg     1560

gggggaaagc cgcagagaag gaagaaccct caggaaggcc tgtacaatga actgcagaaa     1620

gataagatgg cggaggccta cagtgagatt gggatgaaag gcgagcgccg gaggggcaag     1680

gggcacgatg gcctttacca gggtctcagt acagccacca aggacaccta cgacgccctt     1740

cacatgcagg ccctgccccc tcgctagtaa gctagccgat ggctccggtg cccgtcagtg     1800

ggcagagcgc acatcgccca cagtccccga gaagttgggg ggaggggtcg gcaattgaac     1860

cggtgcctag agaaggtggc gcggggtaaa ctgggaaagt gatgtcgtgt actggctccg     1920

cctttttccc gagggtgggg gagaaccgta tataagtgca gtagtcgccg tgaacgttct     1980

ttttcgcaac gggtttgccg ccagaacaca ggtgtcgtga cgcggatcca ggcctaagct     2040

tacgcgtgcc accatggcgc tccctgtcac cgcactgctt cttccgctgg cactgctgct     2100

gcacgctgca cggcctcaga tgcagctagt gcagtctggg gctgaggtga agaagcctgg     2160

ggcctcagtg aaggtttcct gcaaggcatc tggatacacc ttcaccagct actatatgca     2220

ctgggtgcga caggcccctg gacaagggct tgagtggatg ggaataatca accctagtgg     2280

tggtagcaca agctacgcac agaagttcca gggcagagtc accatgacca gggacacgtc     2340

cacgagcaca gtctacatgg agctgagcag cctgagatct gaggacacgg ccgtgtatta     2400

ctgtgcgagt agtcggagtg ggactacggt ggtaaatcat gatgcttttg atatctgggg     2460

gaaagggacc acggtcaccg tctcgagtgg tggaggcggt tcaggcggag gtggttctgg     2520

cggtggcgga tcggacatcc agttgaccca gtctccatcc tccctgtctg cgtctgtagg     2580

agacagagtc accatcactt gccgggcaag ccaggtcatt agccgtgctt tagcctggta     2640

tcaacaaaca ccagggaaac ctcctaaact cctgatctat gatgcctcca atttgcagag     2700

tggggtccca tcaaggttca gcggcagtgg atctgggaca gatttcactc tcaccatcag     2760

ccgcctgcag cctgaagatt ttgcaactta ttactgtcaa cagtttaata gttaccctct     2820

cactttcggc ggagggacca agctggagat caaacgtgga caagatgcaa gttctgctgg     2880

atcaaccagg aataaagatc caacaagacg tccagaacta gaagctggta caaatggaag     2940

aagttcgaca acaagtccct ttgtaaaacc aaatccaggt tctagcacag acggcaacag     3000

cgccggacat tcggggaaca acatcctcgg ttccgaagtg gccttatttg cactcatgta     3060

cgtggcagcg gccgccttcg tgctcctgtt ctttgtgggc tgtggggtgc tgctgtcccg     3120

caagcgccgg cggatgaagc tgctgagcag catcgagcag gcctgtgaca tctgccggct     3180

gaagaaactg aagtgcagca aagaaaagcc caagtgcgcc aagtgcctga agaacaactg     3240

ggagtgccgg tacagcccca agaccaagag aagccccctg accagagccc acctgaccga     3300

ggtggaaagc cggctggaaa gactggaaca gctgtttctg ctgatcttcc cacgcgagga     3360

cctggacatg atcctgaaga tggacagcct gcaggacatc aaggccctgc tgaccggcct     3420

gttcgtgcag gacaacgtga acaaggacgc cgtgaccgac agactggcca gcgtggaaac     3480

cgacatgccc ctgaccctgc ggcagcacag aatcagcgcc accagcagca gcgaggaaag     3540

cagcaacaag ggccagcggc agctgacagt gtctgctgct gcaggcggaa gcggaggctc     3600

tggcggatct gatgccctgg acgacttcga cctggatatg ctgggcagcg acgccctgga     3660

tgattttgat ctggacatgc tgggatctga cgctctggac gatttcgatc tcgacatgtt     3720

gggatcagat gcactggatg actttgacct ggacatgctc ggatca                    3766


<210>  69
<211>  4354
<212>  DNA
<213>  Mesothelin-synEphrinB2EC- Claudin18.2-CAR-IL7

<400>  69
aagcttgata tcgaattcgg agcactgtcc tccgaacgtc ggagcactgt cctccgaacg       60

tcggagcact gtcctccgaa cgtcggagca ctgtcctccg aacggagcat gtcctccgaa      120

cgtcggagca ctgtcctccg aacgactagt taggcgtgta cggtgggagg cctatataag      180

cagagctcgt ttagtgaacc gtcagatcgc ctggagacgc catccacgct gttttgacct      240

ccatagaaga caccgggacc gatccagcct ctcgacattc gttggatcat ggccttacca      300

gtgaccgcct tgctcctgcc gctggccttg ctgctccacg ccgccaggcc gcaggtgcag      360

ctgcaggaga gcggccccgg cctgatcaag cccagccaga ccctgagcct gacctgcacc      420

gtgagcggcg gcagcatcag cagcggctac aactggcact ggatccggca gccccccggc      480

aagggcctgg agtggatcgg ctacatccac tacaccggca gcaccaacta caaccccgcc      540

ctgcggagcc gggtgaccat cagcgtggac accagcaaga accagttcag cctgaagctg      600

agcagcgtga ccgccgccga caccgccatc tactactgcg cccggatcta caacggcaac      660

agcttcccct actggggcca gggcaccacc gtgaccgtga gcagcggtgg aggcggttca      720

ggcggaggtg gttctggcgg tggcggatcg gacatcgtga tgacccagag ccccgacagc      780

ctggccgtga gcctgggcga gcgggccacc atcaactgca agagcagcca gagcctgttc      840

aacagcggca accagaagaa ctacctgacc tggtaccagc agaagcccgg ccagcccccc      900

aagctgctga tctactgggc cagcacccgg gagagcggcg tgcccgaccg gttcagcggc      960

agcggcagcg gcaccgactt caccctgacc atcagcagcc tgcaggccga ggacgtggcc     1020

gtgtactact gccagaacgc ctacagcttc ccctacacct tcggcggcgg caccaagctg     1080

gagatcaagc ggaccacgac gccagcgccg cgaccaccaa caccggcgcc caccatcgcg     1140

tcgcagcccc tgtccctgcg cccagaggcg tgccggccag cggcgggggg cgcagtgcac     1200

acgagggggc tggacttcgc ctgtgatatc tacatctggg cgcccttggc cgggacttgt     1260

ggggtccttc tcctgtcact ggttatcacc ctttactgca aacggggcag aaagaaactc     1320

ctgtatatat tcaaacaacc atttatgaga ccagtacaaa ctactcaaga ggaagatggc     1380

tgtagctgcc gatttccaga agaagaagaa ggaggatgtg aactgagagt gaagttcagc     1440

aggagcgcag acgcccccgc gtaccagcag ggccagaacc agctctataa cgagctcaat     1500

ctaggacgaa gagaggagta cgatgttttg gacaagagac gtggccggga ccctgagatg     1560

gggggaaagc cgcagagaag gaagaaccct caggaaggcc tgtacaatga actgcagaaa     1620

gataagatgg cggaggccta cagtgagatt gggatgaaag gcgagcgccg gaggggcaag     1680

gggcacgatg gcctttacca gggtctcagt acagccacca aggacaccta cgacgccctt     1740

cacatgcagg ccctgccccc tcgcgctact aacttcagcc tgctgaagca ggctggagac     1800

gtggaggaga accctggacc tatgttccat gtttctttta ggtatatctt tggacttcct     1860

cccctgatcc ttgttctgtt gccagtagca tcatctgatt gtgatattga aggtaaagat     1920

ggcaaacaat atgagagtgt tctaatggtc agcatcgatc aattattgga cagcatgaaa     1980

gaaattggta gcaattgcct gaataatgaa tttaactttt ttaaaagaca tatctgtgat     2040

gctaataagg aaggtatgtt tttattccgt gctgctcgca agttgaggca atttcttaaa     2100

atgaatagca ctggtgattt tgatctccac ttattaaaag tttcagaagg cacaacaata     2160

ctgttgaact gcactggcca ggttaaagga agaaaaccag ctgccctggg tgaagcccaa     2220

ccaacaaaga gtttggaaga aaataaatct ttaaaggaac agaaaaaact gaatgacttg     2280

tgtttcctaa agagactatt acaagagata aaaacttgtt ggaataaaat tttgatgggc     2340

actaaagaac actagtaagc tagccgatgg ctccggtgcc cgtcagtggg cagagcgcac     2400

atcgcccaca gtccccgaga agttgggggg aggggtcggc aattgaaccg gtgcctagag     2460

aaggtggcgc ggggtaaact gggaaagtga tgtcgtgtac tggctccgcc tttttcccga     2520

gggtggggga gaaccgtata taagtgcagt agtcgccgtg aacgttcttt ttcgcaacgg     2580

gtttgccgcc agaacacagg tgtcgtgacg cggatccagg cctaagctta cgcgtgccac     2640

catggcgctc cctgtcaccg cactgcttct tccgctggca ctgctgctgc acgctgcacg     2700

gcctcagatg cagctagtgc agtctggggc tgaggtgaag aagcctgggg cctcagtgaa     2760

ggtttcctgc aaggcatctg gatacacctt caccagctac tatatgcact gggtgcgaca     2820

ggcccctgga caagggcttg agtggatggg aataatcaac cctagtggtg gtagcacaag     2880

ctacgcacag aagttccagg gcagagtcac catgaccagg gacacgtcca cgagcacagt     2940

ctacatggag ctgagcagcc tgagatctga ggacacggcc gtgtattact gtgcgagtag     3000

tcggagtggg actacggtgg taaatcatga tgcttttgat atctggggga aagggaccac     3060

ggtcaccgtc tcgagtggtg gaggcggttc aggcggaggt ggttctggcg gtggcggatc     3120

ggacatccag ttgacccagt ctccatcctc cctgtctgcg tctgtaggag acagagtcac     3180

catcacttgc cgggcaagcc aggtcattag ccgtgcttta gcctggtatc aacaaacacc     3240

agggaaacct cctaaactcc tgatctatga tgcctccaat ttgcagagtg gggtcccatc     3300

aaggttcagc ggcagtggat ctgggacaga tttcactctc accatcagcc gcctgcagcc     3360

tgaagatttt gcaacttatt actgtcaaca gtttaatagt taccctctca ctttcggcgg     3420

agggaccaag ctggagatca aacgtggaca agatgcaagt tctgctggat caaccaggaa     3480

taaagatcca acaagacgtc cagaactaga agctggtaca aatggaagaa gttcgacaac     3540

aagtcccttt gtaaaaccaa atccaggttc tagcacagac ggcaacagcg ccggacattc     3600

ggggaacaac atcctcggtt ccgaagtggc cttatttgca ctcatgtacg tggcagcggc     3660

cgccttcgtg ctcctgttct ttgtgggctg tggggtgctg ctgtcccgca agcgccggcg     3720

gatgaagctg ctgagcagca tcgagcaggc ctgtgacatc tgccggctga agaaactgaa     3780

gtgcagcaaa gaaaagccca agtgcgccaa gtgcctgaag aacaactggg agtgccggta     3840

cagccccaag accaagagaa gccccctgac cagagcccac ctgaccgagg tggaaagccg     3900

gctggaaaga ctggaacagc tgtttctgct gatcttccca cgcgaggacc tggacatgat     3960

cctgaagatg gacagcctgc aggacatcaa ggccctgctg accggcctgt tcgtgcagga     4020

caacgtgaac aaggacgccg tgaccgacag actggccagc gtggaaaccg acatgcccct     4080

gaccctgcgg cagcacagaa tcagcgccac cagcagcagc gaggaaagca gcaacaaggg     4140

ccagcggcag ctgacagtgt ctgctgctgc aggcggaagc ggaggctctg gcggatctga     4200

tgccctggac gacttcgacc tggatatgct gggcagcgac gccctggatg attttgatct     4260

ggacatgctg ggatctgacg ctctggacga tttcgatctc gacatgttgg gatcagatgc     4320

actggatgac tttgacctgg acatgctcgg atca                                 4354


<210>  70
<211>  4810
<212>  DNA
<213>  Mesothelin-synEphrinB2EC- Claudin18.2-CAR-IL7-CCL21

<400>  70
aagcttgata tcgaattcgg agcactgtcc tccgaacgtc ggagcactgt cctccgaacg       60

tcggagcact gtcctccgaa cgtcggagca ctgtcctccg aacggagcat gtcctccgaa      120

cgtcggagca ctgtcctccg aacgactagt taggcgtgta cggtgggagg cctatataag      180

cagagctcgt ttagtgaacc gtcagatcgc ctggagacgc catccacgct gttttgacct      240

ccatagaaga caccgggacc gatccagcct ctcgacattc gttggatcat ggccttacca      300

gtgaccgcct tgctcctgcc gctggccttg ctgctccacg ccgccaggcc gcaggtgcag      360

ctgcaggaga gcggccccgg cctgatcaag cccagccaga ccctgagcct gacctgcacc      420

gtgagcggcg gcagcatcag cagcggctac aactggcact ggatccggca gccccccggc      480

aagggcctgg agtggatcgg ctacatccac tacaccggca gcaccaacta caaccccgcc      540

ctgcggagcc gggtgaccat cagcgtggac accagcaaga accagttcag cctgaagctg      600

agcagcgtga ccgccgccga caccgccatc tactactgcg cccggatcta caacggcaac      660

agcttcccct actggggcca gggcaccacc gtgaccgtga gcagcggtgg aggcggttca      720

ggcggaggtg gttctggcgg tggcggatcg gacatcgtga tgacccagag ccccgacagc      780

ctggccgtga gcctgggcga gcgggccacc atcaactgca agagcagcca gagcctgttc      840

aacagcggca accagaagaa ctacctgacc tggtaccagc agaagcccgg ccagcccccc      900

aagctgctga tctactgggc cagcacccgg gagagcggcg tgcccgaccg gttcagcggc      960

agcggcagcg gcaccgactt caccctgacc atcagcagcc tgcaggccga ggacgtggcc     1020

gtgtactact gccagaacgc ctacagcttc ccctacacct tcggcggcgg caccaagctg     1080

gagatcaagc ggaccacgac gccagcgccg cgaccaccaa caccggcgcc caccatcgcg     1140

tcgcagcccc tgtccctgcg cccagaggcg tgccggccag cggcgggggg cgcagtgcac     1200

acgagggggc tggacttcgc ctgtgatatc tacatctggg cgcccttggc cgggacttgt     1260

ggggtccttc tcctgtcact ggttatcacc ctttactgca aacggggcag aaagaaactc     1320

ctgtatatat tcaaacaacc atttatgaga ccagtacaaa ctactcaaga ggaagatggc     1380

tgtagctgcc gatttccaga agaagaagaa ggaggatgtg aactgagagt gaagttcagc     1440

aggagcgcag acgcccccgc gtaccagcag ggccagaacc agctctataa cgagctcaat     1500

ctaggacgaa gagaggagta cgatgttttg gacaagagac gtggccggga ccctgagatg     1560

gggggaaagc cgcagagaag gaagaaccct caggaaggcc tgtacaatga actgcagaaa     1620

gataagatgg cggaggccta cagtgagatt gggatgaaag gcgagcgccg gaggggcaag     1680

gggcacgatg gcctttacca gggtctcagt acagccacca aggacaccta cgacgccctt     1740

cacatgcagg ccctgccccc tcgcgctact aacttcagcc tgctgaagca ggctggagac     1800

gtggaggaga accctggacc tatgttccat gtttctttta ggtatatctt tggacttcct     1860

cccctgatcc ttgttctgtt gccagtagca tcatctgatt gtgatattga aggtaaagat     1920

ggcaaacaat atgagagtgt tctaatggtc agcatcgatc aattattgga cagcatgaaa     1980

gaaattggta gcaattgcct gaataatgaa tttaactttt ttaaaagaca tatctgtgat     2040

gctaataagg aaggtatgtt tttattccgt gctgctcgca agttgaggca atttcttaaa     2100

atgaatagca ctggtgattt tgatctccac ttattaaaag tttcagaagg cacaacaata     2160

ctgttgaact gcactggcca ggttaaagga agaaaaccag ctgccctggg tgaagcccaa     2220

ccaacaaaga gtttggaaga aaataaatct ttaaaggaac agaaaaaact gaatgacttg     2280

tgtttcctaa agagactatt acaagagata aaaacttgtt ggaataaaat tttgatgggc     2340

actaaagaac acgagggcag aggaagtctg ctaacatgcg gtgacgtcga ggagaatcct     2400

ggacctatgg ctcagtcact ggctctgagc ctccttatcc tggttctggc ctttggcatc     2460

cccaggaccc aaggcagtga tggaggggct caggactgtt gcctcaagta cagccaaagg     2520

aagattcccg ccaaggttgt ccgcagctac cggaagcagg aaccaagctt aggctgctcc     2580

atcccagcta tcctgttctt gccccgcaag cgctctcagg cagagctatg tgcagaccca     2640

aaggagctct gggtgcagca gctgatgcag catctggaca agacaccatc cccacagaaa     2700

ccagcccagg gctgcaggaa ggacaggggg gcctccaaga ctggcaagaa aggaaagggc     2760

tccaaaggct gcaagaggac tgagcggtca cagaccccta aagggccata gtaagctagc     2820

cgatggctcc ggtgcccgtc agtgggcaga gcgcacatcg cccacagtcc ccgagaagtt     2880

ggggggaggg gtcggcaatt gaaccggtgc ctagagaagg tggcgcgggg taaactggga     2940

aagtgatgtc gtgtactggc tccgcctttt tcccgagggt gggggagaac cgtatataag     3000

tgcagtagtc gccgtgaacg ttctttttcg caacgggttt gccgccagaa cacaggtgtc     3060

gtgacgcgga tccaggccta agcttacgcg tgccaccatg gcgctccctg tcaccgcact     3120

gcttcttccg ctggcactgc tgctgcacgc tgcacggcct cagatgcagc tagtgcagtc     3180

tggggctgag gtgaagaagc ctggggcctc agtgaaggtt tcctgcaagg catctggata     3240

caccttcacc agctactata tgcactgggt gcgacaggcc cctggacaag ggcttgagtg     3300

gatgggaata atcaacccta gtggtggtag cacaagctac gcacagaagt tccagggcag     3360

agtcaccatg accagggaca cgtccacgag cacagtctac atggagctga gcagcctgag     3420

atctgaggac acggccgtgt attactgtgc gagtagtcgg agtgggacta cggtggtaaa     3480

tcatgatgct tttgatatct gggggaaagg gaccacggtc accgtctcga gtggtggagg     3540

cggttcaggc ggaggtggtt ctggcggtgg cggatcggac atccagttga cccagtctcc     3600

atcctccctg tctgcgtctg taggagacag agtcaccatc acttgccggg caagccaggt     3660

cattagccgt gctttagcct ggtatcaaca aacaccaggg aaacctccta aactcctgat     3720

ctatgatgcc tccaatttgc agagtggggt cccatcaagg ttcagcggca gtggatctgg     3780

gacagatttc actctcacca tcagccgcct gcagcctgaa gattttgcaa cttattactg     3840

tcaacagttt aatagttacc ctctcacttt cggcggaggg accaagctgg agatcaaacg     3900

tggacaagat gcaagttctg ctggatcaac caggaataaa gatccaacaa gacgtccaga     3960

actagaagct ggtacaaatg gaagaagttc gacaacaagt ccctttgtaa aaccaaatcc     4020

aggttctagc acagacggca acagcgccgg acattcgggg aacaacatcc tcggttccga     4080

agtggcctta tttgcactca tgtacgtggc agcggccgcc ttcgtgctcc tgttctttgt     4140

gggctgtggg gtgctgctgt cccgcaagcg ccggcggatg aagctgctga gcagcatcga     4200

gcaggcctgt gacatctgcc ggctgaagaa actgaagtgc agcaaagaaa agcccaagtg     4260

cgccaagtgc ctgaagaaca actgggagtg ccggtacagc cccaagacca agagaagccc     4320

cctgaccaga gcccacctga ccgaggtgga aagccggctg gaaagactgg aacagctgtt     4380

tctgctgatc ttcccacgcg aggacctgga catgatcctg aagatggaca gcctgcagga     4440

catcaaggcc ctgctgaccg gcctgttcgt gcaggacaac gtgaacaagg acgccgtgac     4500

cgacagactg gccagcgtgg aaaccgacat gcccctgacc ctgcggcagc acagaatcag     4560

cgccaccagc agcagcgagg aaagcagcaa caagggccag cggcagctga cagtgtctgc     4620

tgctgcaggc ggaagcggag gctctggcgg atctgatgcc ctggacgact tcgacctgga     4680

tatgctgggc agcgacgccc tggatgattt tgatctggac atgctgggat ctgacgctct     4740

ggacgatttc gatctcgaca tgttgggatc agatgcactg gatgactttg acctggacat     4800

gctcggatca                                                            4810


<210>  71
<211>  3757
<212>  DNA
<213>  FAP-synEphrinB2EC-Claudin18.2-CAR

<400>  71
aagcttgata tcgaattcgg agcactgtcc tccgaacgtc ggagcactgt cctccgaacg       60

tcggagcact gtcctccgaa cgtcggagca ctgtcctccg aacggagcat gtcctccgaa      120

cgtcggagca ctgtcctccg aacgactagt taggcgtgta cggtgggagg cctatataag      180

cagagctcgt ttagtgaacc gtcagatcgc ctggagacgc catccacgct gttttgacct      240

ccatagaaga caccgggacc gatccagcct ctcgacattc gttggatcat ggccttacca      300

gtgaccgcct tgctcctgcc gctggccttg ctgctccacg ccgccaggcc gcaggtgcag      360

ctgcaggaga gcggccccgg cctgatcaag cccagccaga ccctgagcct gacctgcacc      420

gtgagcggcg gcagcatcag cagcggctac aactggcact ggatccggca gccccccggc      480

aagggcctgg agtggatcgg ctacatccac tacaccggca gcaccaacta caaccccgcc      540

ctgcggagcc gggtgaccat cagcgtggac accagcaaga accagttcag cctgaagctg      600

agcagcgtga ccgccgccga caccgccatc tactactgcg cccggatcta caacggcaac      660

agcttcccct actggggcca gggcaccacc gtgaccgtga gcagcggtgg aggcggttca      720

ggcggaggtg gttctggcgg tggcggatcg gacatcgtga tgacccagag ccccgacagc      780

ctggccgtga gcctgggcga gcgggccacc atcaactgca agagcagcca gagcctgttc      840

aacagcggca accagaagaa ctacctgacc tggtaccagc agaagcccgg ccagcccccc      900

aagctgctga tctactgggc cagcacccgg gagagcggcg tgcccgaccg gttcagcggc      960

agcggcagcg gcaccgactt caccctgacc atcagcagcc tgcaggccga ggacgtggcc     1020

gtgtactact gccagaacgc ctacagcttc ccctacacct tcggcggcgg caccaagctg     1080

gagatcaagc ggaccacgac gccagcgccg cgaccaccaa caccggcgcc caccatcgcg     1140

tcgcagcccc tgtccctgcg cccagaggcg tgccggccag cggcgggggg cgcagtgcac     1200

acgagggggc tggacttcgc ctgtgatatc tacatctggg cgcccttggc cgggacttgt     1260

ggggtccttc tcctgtcact ggttatcacc ctttactgca aacggggcag aaagaaactc     1320

ctgtatatat tcaaacaacc atttatgaga ccagtacaaa ctactcaaga ggaagatggc     1380

tgtagctgcc gatttccaga agaagaagaa ggaggatgtg aactgagagt gaagttcagc     1440

aggagcgcag acgcccccgc gtaccagcag ggccagaacc agctctataa cgagctcaat     1500

ctaggacgaa gagaggagta cgatgttttg gacaagagac gtggccggga ccctgagatg     1560

gggggaaagc cgcagagaag gaagaaccct caggaaggcc tgtacaatga actgcagaaa     1620

gataagatgg cggaggccta cagtgagatt gggatgaaag gcgagcgccg gaggggcaag     1680

gggcacgatg gcctttacca gggtctcagt acagccacca aggacaccta cgacgccctt     1740

cacatgcagg ccctgccccc tcgctagtaa gctagccgat ggctccggtg cccgtcagtg     1800

ggcagagcgc acatcgccca cagtccccga gaagttgggg ggaggggtcg gcaattgaac     1860

cggtgcctag agaaggtggc gcggggtaaa ctgggaaagt gatgtcgtgt actggctccg     1920

cctttttccc gagggtgggg gagaaccgta tataagtgca gtagtcgccg tgaacgttct     1980

ttttcgcaac gggtttgccg ccagaacaca ggtgtcgtga cgcggatcca ggcctaagct     2040

tacgcgtgcc accatggcgc tccctgtcac cgcactgctt cttccgctgg cactgctgct     2100

gcacgctgca cggcctcagg tgcaattggt gcagtctggg gctgaggtga agaagcctgg     2160

gtcctcggtg aaggtctcct gcaaggcctc cggaggcaca ttcagcagct acgctataag     2220

ctgggtgcga caggcccctg gacaagggct cgagtggatg ggagggatca tccctatctt     2280

tggtacagca aactacgcac agaagttcca gggcagggtc accattactg cagacaaatc     2340

cacgagcaca gcctacatgg agctgagcag cctgagatct gaggacaccg ccgtgtatta     2400

ctgtgcgaga gatgctgctg atagggacta ctggggccaa gggaccaccg tgaccgtctc     2460

ctcaggtgga ggcggttcag gcggaggtgg ttctggcggt ggcggatcgg atattgttat     2520

gactcaatct ccactgtctc tgccggtgac tccaggcgaa ccggcgagca tttcttgccg     2580

ttccagccag tctctgcttc accccaacgg cttcaaccat ctctattggt acctgcaaaa     2640

accgggtcag agccctcagc tgctgatcta cgtggggggt aaccgcgctt ccggtgtacc     2700

ggaccgtttc agcggctctg gatccggcac cgatttcacg ttgaaaatca gccgtgttga     2760

agcagaagac gtgggcgttt attactgtca gcagcgtaat aataagaatc gtacttttgg     2820

tcaaggcacc aaggtcgaaa ttaaacgtgg acaagatgca agttctgctg gatcaaccag     2880

gaataaagat ccaacaagac gtccagaact agaagctggt acaaatggaa gaagttcgac     2940

aacaagtccc tttgtaaaac caaatccagg ttctagcaca gacggcaaca gcgccggaca     3000

ttcggggaac aacatcctcg gttccgaagt ggccttattt gcactcatgt acgtggcagc     3060

ggccgccttc gtgctcctgt tctttgtggg ctgtggggtg ctgctgtccc gcaagcgccg     3120

gcggatgaag ctgctgagca gcatcgagca ggcctgtgac atctgccggc tgaagaaact     3180

gaagtgcagc aaagaaaagc ccaagtgcgc caagtgcctg aagaacaact gggagtgccg     3240

gtacagcccc aagaccaaga gaagccccct gaccagagcc cacctgaccg aggtggaaag     3300

ccggctggaa agactggaac agctgtttct gctgatcttc ccacgcgagg acctggacat     3360

gatcctgaag atggacagcc tgcaggacat caaggccctg ctgaccggcc tgttcgtgca     3420

ggacaacgtg aacaaggacg ccgtgaccga cagactggcc agcgtggaaa ccgacatgcc     3480

cctgaccctg cggcagcaca gaatcagcgc caccagcagc agcgaggaaa gcagcaacaa     3540

gggccagcgg cagctgacag tgtctgctgc tgcaggcgga agcggaggct ctggcggatc     3600

tgatgccctg gacgacttcg acctggatat gctgggcagc gacgccctgg atgattttga     3660

tctggacatg ctgggatctg acgctctgga cgatttcgat ctcgacatgt tgggatcaga     3720

tgcactggat gactttgacc tggacatgct cggatca                              3757


<210>  72
<211>  3782
<212>  DNA
<213>  Claudin18.2-synEphrinB2EC-Mesothelin-CAR

<400>  72
aagcttgata tcgaattcgg agcactgtcc tccgaacgtc ggagcactgt cctccgaacg       60

tcggagcact gtcctccgaa cgtcggagca ctgtcctccg aacggagcat gtcctccgaa      120

cgtcggagca ctgtcctccg aacgactagt taggcgtgta cggtgggagg cctatataag      180

cagagctcgt ttagtgaacc gtcagatcgc ctggagacgc catccacgct gttttgacct      240

ccatagaaga caccgggacc gatccagcct ctcgacattc gttggatcat ggccttacca      300

gtgaccgcct tgctcctgcc gctggccttg ctgctccacg ccgccaggcc gcagatgcag      360

ctagtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt ttcctgcaag      420

gcatctggat acaccttcac cagctactat atgcactggg tgcgacaggc ccctggacaa      480

gggcttgagt ggatgggaat aatcaaccct agtggtggta gcacaagcta cgcacagaag      540

ttccagggca gagtcaccat gaccagggac acgtccacga gcacagtcta catggagctg      600

agcagcctga gatctgagga cacggccgtg tattactgtg cgagtagtcg gagtgggact      660

acggtggtaa atcatgatgc ttttgatatc tgggggaaag ggaccacggt caccgtctcg      720

agtggtggag gcggttcagg cggaggtggt tctggcggtg gcggatcgga catccagttg      780

acccagtctc catcctccct gtctgcgtct gtaggagaca gagtcaccat cacttgccgg      840

gcaagccagg tcattagccg tgctttagcc tggtatcaac aaacaccagg gaaacctcct      900

aaactcctga tctatgatgc ctccaatttg cagagtgggg tcccatcaag gttcagcggc      960

agtggatctg ggacagattt cactctcacc atcagccgcc tgcagcctga agattttgca     1020

acttattact gtcaacagtt taatagttac cctctcactt tcggcggagg gaccaagctg     1080

gagatcaaac gtaccacgac gccagcgccg cgaccaccaa caccggcgcc caccatcgcg     1140

tcgcagcccc tgtccctgcg cccagaggcg tgccggccag cggcgggggg cgcagtgcac     1200

acgagggggc tggacttcgc ctgtgatatc tacatctggg cgcccttggc cgggacttgt     1260

ggggtccttc tcctgtcact ggttatcacc ctttactgca aacggggcag aaagaaactc     1320

ctgtatatat tcaaacaacc atttatgaga ccagtacaaa ctactcaaga ggaagatggc     1380

tgtagctgcc gatttccaga agaagaagaa ggaggatgtg aactgagagt gaagttcagc     1440

aggagcgcag acgcccccgc gtaccagcag ggccagaacc agctctataa cgagctcaat     1500

ctaggacgaa gagaggagta cgatgttttg gacaagagac gtggccggga ccctgagatg     1560

gggggaaagc cgcagagaag gaagaaccct caggaaggcc tgtacaatga actgcagaaa     1620

gataagatgg cggaggccta cagtgagatt gggatgaaag gcgagcgccg gaggggcaag     1680

gggcacgatg gcctttacca gggtctcagt acagccacca aggacaccta cgacgccctt     1740

cacatgcagg ccctgccccc tcgctagtaa gctagccgat ggctccggtg cccgtcagtg     1800

ggcagagcgc acatcgccca cagtccccga gaagttgggg ggaggggtcg gcaattgaac     1860

cggtgcctag agaaggtggc gcggggtaaa ctgggaaagt gatgtcgtgt actggctccg     1920

cctttttccc gagggtgggg gagaaccgta tataagtgca gtagtcgccg tgaacgttct     1980

ttttcgcaac gggtttgccg ccagaacaca ggtgtcgtga cgcggatcca ggcctaagct     2040

tacgcgtcct agcgctaccg gtcgccacca tggccttacc agtgaccgcc ttgctcctgc     2100

cgctggcctt gctgctccac gccgccaggc cgcaggtgca gctgcaggag agcggccccg     2160

gcctgatcaa gcccagccag accctgagcc tgacctgcac cgtgagcggc ggcagcatca     2220

gcagcggcta caactggcac tggatccggc agccccccgg caagggcctg gagtggatcg     2280

gctacatcca ctacaccggc agcaccaact acaaccccgc cctgcggagc cgggtgacca     2340

tcagcgtgga caccagcaag aaccagttca gcctgaagct gagcagcgtg accgccgccg     2400

acaccgccat ctactactgc gcccggatct acaacggcaa cagcttcccc tactggggcc     2460

agggcaccac cgtgaccgtg agcagcggtg gaggcggttc aggcggaggt ggttctggcg     2520

gtggcggatc ggacatcgtg atgacccaga gccccgacag cctggccgtg agcctgggcg     2580

agcgggccac catcaactgc aagagcagcc agagcctgtt caacagcggc aaccagaaga     2640

actacctgac ctggtaccag cagaagcccg gccagccccc caagctgctg atctactggg     2700

ccagcacccg ggagagcggc gtgcccgacc ggttcagcgg cagcggcagc ggcaccgact     2760

tcaccctgac catcagcagc ctgcaggccg aggacgtggc cgtgtactac tgccagaacg     2820

cctacagctt cccctacacc ttcggcggcg gcaccaagct ggagatcaag cggggacaag     2880

atgcaagttc tgctggatca accaggaata aagatccaac aagacgtcca gaactagaag     2940

ctggtacaaa tggaagaagt tcgacaacaa gtccctttgt aaaaccaaat ccaggttcta     3000

gcacagacgg caacagcgcc ggacattcgg ggaacaacat cctcggttcc gaagtggcct     3060

tatttgcact catgtacgtg gcagcggccg ccttcgtgct cctgttcttt gtgggctgtg     3120

gggtgctgct gtcccgcaag cgccggcgga tgaagctgct gagcagcatc gagcaggcct     3180

gtgacatctg ccggctgaag aaactgaagt gcagcaaaga aaagcccaag tgcgccaagt     3240

gcctgaagaa caactgggag tgccggtaca gccccaagac caagagaagc cccctgacca     3300

gagcccacct gaccgaggtg gaaagccggc tggaaagact ggaacagctg tttctgctga     3360

tcttcccacg cgaggacctg gacatgatcc tgaagatgga cagcctgcag gacatcaagg     3420

ccctgctgac cggcctgttc gtgcaggaca acgtgaacaa ggacgccgtg accgacagac     3480

tggccagcgt ggaaaccgac atgcccctga ccctgcggca gcacagaatc agcgccacca     3540

gcagcagcga ggaaagcagc aacaagggcc agcggcagct gacagtgtct gctgctgcag     3600

gcggaagcgg aggctctggc ggatctgatg ccctggacga cttcgacctg gatatgctgg     3660

gcagcgacgc cctggatgat tttgatctgg acatgctggg atctgacgct ctggacgatt     3720

tcgatctcga catgttggga tcagatgcac tggatgactt tgacctggac atgctcggat     3780

ca                                                                    3782


<210>  73
<211>  544
<212>  PRT
<213>  CLL1-synEphrinB2EC

<400>  73

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Asn Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Phe Asn Pro Gly Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Thr Ser Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
    130                 135                 140                 


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln 
145                 150                 155                 160 


Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
                165                 170                 175     


Pro Lys Leu Leu Ile Asp Val Ala Ser Ser Leu Gln Ser Gly Val Pro 
            180                 185                 190         


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
        195                 200                 205             


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser 
    210                 215                 220                 


Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
225                 230                 235                 240 


Arg Gly Gln Asp Ala Ser Ser Ala Gly Ser Thr Arg Asn Lys Asp Pro 
                245                 250                 255     


Thr Arg Arg Pro Glu Leu Glu Ala Gly Thr Asn Gly Arg Ser Ser Thr 
            260                 265                 270         


Thr Ser Pro Phe Val Lys Pro Asn Pro Gly Ser Ser Thr Asp Gly Asn 
        275                 280                 285             


Ser Ala Gly His Ser Gly Asn Asn Ile Leu Gly Ser Glu Val Ala Leu 
    290                 295                 300                 


Phe Ala Leu Met Tyr Val Ala Ala Ala Ala Phe Val Leu Leu Phe Phe 
305                 310                 315                 320 


Val Gly Cys Gly Val Leu Leu Ser Arg Lys Arg Arg Arg Met Lys Leu 
                325                 330                 335     


Leu Ser Ser Ile Glu Gln Ala Cys Asp Ile Cys Arg Leu Lys Lys Leu 
            340                 345                 350         


Lys Cys Ser Lys Glu Lys Pro Lys Cys Ala Lys Cys Leu Lys Asn Asn 
        355                 360                 365             


Trp Glu Cys Arg Tyr Ser Pro Lys Thr Lys Arg Ser Pro Leu Thr Arg 
    370                 375                 380                 


Ala His Leu Thr Glu Val Glu Ser Arg Leu Glu Arg Leu Glu Gln Leu 
385                 390                 395                 400 


Phe Leu Leu Ile Phe Pro Arg Glu Asp Leu Asp Met Ile Leu Lys Met 
                405                 410                 415     


Asp Ser Leu Gln Asp Ile Lys Ala Leu Leu Thr Gly Leu Phe Val Gln 
            420                 425                 430         


Asp Asn Val Asn Lys Asp Ala Val Thr Asp Arg Leu Ala Ser Val Glu 
        435                 440                 445             


Thr Asp Met Pro Leu Thr Leu Arg Gln His Arg Ile Ser Ala Thr Ser 
    450                 455                 460                 


Ser Ser Glu Glu Ser Ser Asn Lys Gly Gln Arg Gln Leu Thr Val Ser 
465                 470                 475                 480 


Ala Ala Ala Gly Gly Ser Gly Gly Ser Gly Gly Ser Asp Ala Leu Asp 
                485                 490                 495     


Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp 
            500                 505                 510         


Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met 
        515                 520                 525             


Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser 
    530                 535                 540                 


<210>  74
<211>  3274
<212>  DNA
<213>  CLL1-synEphrinB2EC-NKG2D-CAR

<400>  74
aagcttgata tcgaattcgg agcactgtcc tccgaacgtc ggagcactgt cctccgaacg       60

tcggagcact gtcctccgaa cgtcggagca ctgtcctccg aacggagcat gtcctccgaa      120

cgtcggagca ctgtcctccg aacgactagt taggcgtgta cggtgggagg cctatataag      180

cagagctcgt ttagtgaacc gtcagatcgc ctggagacgc catccacgct gttttgacct      240

ccatagaaga caccgggacc gatccagcct ctcgacattc gttggatcat gagagtgaag      300

ttcagcagga gcgcagacgc ccccgcgtac cagcagggcc agaaccagct ctataacgag      360

ctcaatctag gacgaagaga ggagtacgat gttttggaca agagacgtgg ccgggaccct      420

gagatggggg gaaagccgca gagaaggaag aaccctcagg aaggcctgta caatgaactg      480

cagaaagata agatggcgga ggcctacagt gagattggga tgaaaggcga gcgccggagg      540

ggcaaggggc acgatggcct ttaccagggt ctcagtacag ccaccaagga cacctacgac      600

gcccttcaca tgcaggccct gccccctcgc gggtggattc gtggtcggag gtctcgacac      660

agctgggaga tgagtgaatt tcataattat aacttggatc tgaagaagag tgatttttca      720

acacgatggc aaaagcaaag atgtccagta gtcaaaagca aatgtagaga aaatgcatct      780

ccattttttt tctgctgctt catcgctgta gccatgggaa tccgtttcat tattatggta      840

gctatatgga gtgctgtatt cctaaactca ttattcaacc aagaagttca aattcccttg      900

accgaaagtt actgtggccc atgtcctaaa aactggatat gttacaaaaa taactgctac      960

caattttttg atgagagtaa aaactggtat gagagccagg cttcttgtat gtctcaaaat     1020

gccagccttc tgaaagtata cagcaaagag gaccaggatt tacttaaact ggtgaagtca     1080

tatcattgga tgggactagt acacattcca acaaatggat cttggcagtg ggaagatggc     1140

tccattctct cacccaacct actaacaata attgaaatgc agaagggaga ctgtgcactc     1200

tatgcctcga gctttaaagg ctatatagaa aactgttcaa ctccaaatac gtacatctgc     1260

atgcaaagga ctgtgtaagc tagcatcgat ggctccggtg cccgtcagtg ggcagagcgc     1320

acatcgccca cagtccccga gaagttgggg ggaggggtcg gcaattgaac cggtgcctag     1380

agaaggtggc gcggggtaaa ctgggaaagt gatgtcgtgt actggctccg cctttttccc     1440

gagggtgggg gagaaccgta tataagtgca gtagtcgccg tgaacgttct ttttcgcaac     1500

gggtttgccg ccagaacaca ggtgtcgtga cgcggatcca ggcctaagct tacgcgtcct     1560

agcgctaccg gtcgccacca tggcgctccc tgtcaccgca ctgcttcttc cgctggcact     1620

gctgctgcac gctgcacggc ctgaggtgca gctggtgcag tctggggctg aggtgaagaa     1680

gcctggggcc tcagtgaagg tttcctgcaa ggcatctgga tacaccttca acagctacta     1740

tatgcactgg gtgcgacagg cccctggaca agggcttgag tggatgggaa tattcaaccc     1800

tggtggtggt agcacaagct acgcacagaa gttccagggc agagtcacca tgaccaggga     1860

cacgtccacg agcacagtct acatggagct gagcagcctg agatctgagg acacggccgt     1920

gtattactgt gcgagaggaa ctacatccga tgcttttgat atctggggcc aagggacaat     1980

ggtcaccgtc tcgagtggtg gaggcggttc aggcggaggt ggttctggcg gtggcggatc     2040

ggacatccag atgacccagt ctccatcctc cctgtctgca tctgtaggag acagagtcac     2100

catcacttgc cgggcaagtc agagcattag cagctattta aattggtatc agcagaaacc     2160

agggaaagcc cctaagctcc tgatcgatgt cgcatccagt ttgcaaagtg gggtcccatc     2220

aaggttcagt ggcagtggat ctgggacaga tttcactctc accatcagca gtctgcaacc     2280

tgaagatttt gcaacttact actgtcaaca gagttacagt acccctctca ctttcggcgg     2340

agggaccaag gtggagatca aacgtggaca agatgcaagt tctgctggat caaccaggaa     2400

taaagatcca acaagacgtc cagaactaga agctggtaca aatggaagaa gttcgacaac     2460

aagtcccttt gtaaaaccaa atccaggttc tagcacagac ggcaacagcg ccggacattc     2520

ggggaacaac atcctcggtt ccgaagtggc cttatttgca ctcatgtacg tggcagcggc     2580

cgccttcgtg ctcctgttct ttgtgggctg tggggtgctg ctgtcccgca agcgccggcg     2640

gatgaagctg ctgagcagca tcgagcaggc ctgtgacatc tgccggctga agaaactgaa     2700

gtgcagcaaa gaaaagccca agtgcgccaa gtgcctgaag aacaactggg agtgccggta     2760

cagccccaag accaagagaa gccccctgac cagagcccac ctgaccgagg tggaaagccg     2820

gctggaaaga ctggaacagc tgtttctgct gatcttccca cgcgaggacc tggacatgat     2880

cctgaagatg gacagcctgc aggacatcaa ggccctgctg accggcctgt tcgtgcagga     2940

caacgtgaac aaggacgccg tgaccgacag actggccagc gtggaaaccg acatgcccct     3000

gaccctgcgg cagcacagaa tcagcgccac cagcagcagc gaggaaagca gcaacaaggg     3060

ccagcggcag ctgacagtgt ctgctgctgc aggcggaagc ggaggctctg gcggatctga     3120

tgccctggac gacttcgacc tggatatgct gggcagcgac gccctggatg attttgatct     3180

ggacatgctg ggatctgacg ctctggacga tttcgatctc gacatgttgg gatcagatgc     3240

actggatgac tttgacctgg acatgctcgg atca                                 3274


<210>  75
<211>  45
<212>  PRT
<213>  CD8

<400>  75

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  76
<211>  24
<212>  PRT
<213>  CD8Ĥ

<400>  76

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr Cys 
            20                  


<210>  77
<211>  27
<212>  PRT
<213>  CD28Ĥ

<400>  77

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25          


<210>  78
<211>  41
<212>  PRT
<213>  CD28

<400>  78

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  79
<211>  42
<212>  PRT
<213>  4-1BB

<400>  79

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  80
<211>  113
<212>  PRT
<213>  CD3

<400>  80

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    50                  55                  60                  


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
65                  70                  75                  80  


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                85                  90                  95      


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
            100                 105                 110         


Arg 
    


<210>  81
<211>  21
<212>  PRT
<213>  CD8ź

<400>  81

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  82
<211>  226
<212>  PRT
<213>  28Z

<400>  82

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe Trp Val 
        35                  40                  45              


Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr 
    50                  55                  60                  


Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu 
65                  70                  75                  80  


His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg 
                85                  90                  95      


Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg 
            100                 105                 110         


Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
        115                 120                 125             


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
    130                 135                 140                 


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
145                 150                 155                 160 


Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
                165                 170                 175     


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
            180                 185                 190         


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
        195                 200                 205             


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
    210                 215                 220                 


Pro Arg 
225     


<210>  83
<211>  224
<212>  PRT
<213>  BBZ

<400>  83

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
        35                  40                  45              


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
    50                  55                  60                  


Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
65                  70                  75                  80  


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
                85                  90                  95      


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
            100                 105                 110         


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
        115                 120                 125             


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
    130                 135                 140                 


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
145                 150                 155                 160 


Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
                165                 170                 175     


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
            180                 185                 190         


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
        195                 200                 205             


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    210                 215                 220                 


<210>  84
<211>  268
<212>  PRT
<213>  28BBZ

<400>  84

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe Trp Val 
        35                  40                  45              


Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr 
    50                  55                  60                  


Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu 
65                  70                  75                  80  


His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg 
                85                  90                  95      


Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg 
            100                 105                 110         


Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
        115                 120                 125             


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
    130                 135                 140                 


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser 
145                 150                 155                 160 


Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
                165                 170                 175     


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
            180                 185                 190         


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys 
        195                 200                 205             


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
    210                 215                 220                 


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
225                 230                 235                 240 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
                245                 250                 255     


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            260                 265             


<210>  85
<211>  92
<212>  PRT
<213>  synEphrinB2EC-8ؽṹ

<400>  85

Gly Gln Asp Ala Ser Ser Ala Gly Ser Thr Arg Asn Lys Asp Pro Thr 
1               5                   10                  15      


Arg Arg Pro Glu Leu Glu Ala Gly Thr Asn Gly Arg Ser Ser Thr Thr 
            20                  25                  30          


Ser Pro Phe Val Lys Pro Asn Pro Gly Ser Ser Thr Asp Gly Asn Ser 
        35                  40                  45              


Ala Gly His Ser Gly Asn Asn Ile Leu Gly Ser Glu Val Ala Leu Phe 
    50                  55                  60                  


Ala Phe Met Tyr Val Ala Ala Ala Ala Phe Val Leu Leu Phe Phe Val 
65                  70                  75                  80  


Gly Cys Gly Val Leu Leu Ser Arg Lys Arg Arg Arg 
                85                  90          


<210>  86
<211>  242
<212>  PRT
<213>  anti CD123-scFv

<400>  86

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Asp Ser Phe Tyr Gly Gly Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Thr 
    130                 135                 140                 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
145                 150                 155                 160 


Gln Ser Ile Ser Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
                165                 170                 175     


Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val 
            180                 185                 190         


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Tyr Ser Ser Tyr Lys Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
225                 230                 235                 240 


Lys Arg 
        


<210>  87
<211>  556
<212>  PRT
<213>  GPC3-EphrinB2ECУsynotchĤ

<400>  87

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Glu Val Gln Leu Val Gln 
1               5                   10                  15      


Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys 
            20                  25                  30          


Lys Ala Ser Gly Tyr Thr Phe Ser Asp Tyr Glu Met His Trp Val Arg 
        35                  40                  45              


Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Ala Ile His Pro Gly 
    50                  55                  60                  


Ser Gly Asp Thr Ala Tyr Asn Gln Arg Phe Lys Gly Arg Val Thr Ile 
65                  70                  75                  80  


Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu 
                85                  90                  95      


Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Phe Tyr Ser Tyr 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met 
    130                 135                 140                 


Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly Glu Pro Ala Ser 
145                 150                 155                 160 


Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr 
                165                 170                 175     


Tyr Leu Gln Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu 
            180                 185                 190         


Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser 
        195                 200                 205             


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu 
    210                 215                 220                 


Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Ser Ile Tyr Val Pro 
225                 230                 235                 240 


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Gly Gln Asp 
                245                 250                 255     


Ala Ser Ser Ala Gly Ser Thr Arg Asn Lys Asp Pro Thr Arg Arg Pro 
            260                 265                 270         


Glu Leu Glu Ala Gly Thr Asn Gly Arg Ser Ser Thr Thr Ser Pro Phe 
        275                 280                 285             


Val Lys Pro Asn Pro Gly Ser Ser Thr Asp Gly Asn Ser Ala Gly His 
    290                 295                 300                 


Ser Gly Asn Asn Ile Leu Gly Ser Glu Val Ala Leu Phe Ala Phe Met 
305                 310                 315                 320 


Tyr Val Ala Ala Ala Ala Phe Val Leu Leu Phe Phe Val Gly Cys Gly 
                325                 330                 335     


Val Leu Leu Ser Arg Lys Arg Arg Arg Met Lys Leu Leu Ser Ser Ile 
            340                 345                 350         


Glu Gln Ala Cys Asp Ile Cys Arg Leu Lys Lys Leu Lys Cys Ser Lys 
        355                 360                 365             


Glu Lys Pro Lys Cys Ala Lys Cys Leu Lys Asn Asn Trp Glu Cys Arg 
    370                 375                 380                 


Tyr Ser Pro Lys Thr Lys Arg Ser Pro Leu Thr Arg Ala His Leu Thr 
385                 390                 395                 400 


Glu Val Glu Ser Arg Leu Glu Arg Leu Glu Gln Leu Phe Leu Leu Ile 
                405                 410                 415     


Phe Pro Arg Glu Asp Leu Asp Met Ile Leu Lys Met Asp Ser Leu Gln 
            420                 425                 430         


Asp Ile Lys Ala Leu Leu Thr Gly Leu Phe Val Gln Asp Asn Val Asn 
        435                 440                 445             


Lys Asp Ala Val Thr Asp Arg Leu Ala Ser Val Glu Thr Asp Met Pro 
    450                 455                 460                 


Leu Thr Leu Arg Gln His Arg Ile Ser Ala Thr Ser Ser Ser Glu Glu 
465                 470                 475                 480 


Ser Ser Asn Lys Gly Gln Arg Gln Leu Thr Val Ser Ala Ala Ala Gly 
                485                 490                 495     


Gly Ser Gly Gly Ser Gly Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu 
            500                 505                 510         


Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu 
        515                 520                 525             


Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp 
    530                 535                 540                 


Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser 
545                 550                 555     


<210>  88
<211>  3277
<212>  DNA
<213>  CD123-synEphrinB2EC-NKG2D-CAR

<400>  88
aagcttgata tcgaattcgg agcactgtcc tccgaacgtc ggagcactgt cctccgaacg       60

tcggagcact gtcctccgaa cgtcggagca ctgtcctccg aacggagcat gtcctccgaa      120

cgtcggagca ctgtcctccg aacgactagt taggcgtgta cggtgggagg cctatataag      180

cagagctcgt ttagtgaacc gtcagatcgc ctggagacgc catccacgct gttttgacct      240

ccatagaaga caccgggacc gatccagcct ctcgacattc gttggatcat gagagtgaag      300

ttcagcagga gcgcagacgc ccccgcgtac cagcagggcc agaaccagct ctataacgag      360

ctcaatctag gacgaagaga ggagtacgat gttttggaca agagacgtgg ccgggaccct      420

gagatggggg gaaagccgca gagaaggaag aaccctcagg aaggcctgta caatgaactg      480

cagaaagata agatggcgga ggcctacagt gagattggga tgaaaggcga gcgccggagg      540

ggcaaggggc acgatggcct ttaccagggt ctcagtacag ccaccaagga cacctacgac      600

gcccttcaca tgcaggccct gccccctcgc gggtggattc gtggtcggag gtctcgacac      660

agctgggaga tgagtgaatt tcataattat aacttggatc tgaagaagag tgatttttca      720

acacgatggc aaaagcaaag atgtccagta gtcaaaagca aatgtagaga aaatgcatct      780

ccattttttt tctgctgctt catcgctgta gccatgggaa tccgtttcat tattatggta      840

gctatatgga gtgctgtatt cctaaactca ttattcaacc aagaagttca aattcccttg      900

accgaaagtt actgtggccc atgtcctaaa aactggatat gttacaaaaa taactgctac      960

caattttttg atgagagtaa aaactggtat gagagccagg cttcttgtat gtctcaaaat     1020

gccagccttc tgaaagtata cagcaaagag gaccaggatt tacttaaact ggtgaagtca     1080

tatcattgga tgggactagt acacattcca acaaatggat cttggcagtg ggaagatggc     1140

tccattctct cacccaacct actaacaata attgaaatgc agaagggaga ctgtgcactc     1200

tatgcctcga gctttaaagg ctatatagaa aactgttcaa ctccaaatac gtacatctgc     1260

atgcaaagga ctgtgtaagc tagcatcgat ggctccggtg cccgtcagtg ggcagagcgc     1320

acatcgccca cagtccccga gaagttgggg ggaggggtcg gcaattgaac cggtgcctag     1380

agaaggtggc gcggggtaaa ctgggaaagt gatgtcgtgt actggctccg cctttttccc     1440

gagggtgggg gagaaccgta tataagtgca gtagtcgccg tgaacgttct ttttcgcaac     1500

gggtttgccg ccagaacaca ggtgtcgtga cgcggatcca ggcctaagct tacgcgtcct     1560

agcgctaccg gtcgccacca tggccttacc agtgaccgcc ttgctcctgc cgctggcctt     1620

gctgctccac gccgccaggc cggaggtgca attgctggag tctgggggag gcttggtaca     1680

gcctgggggg tccctgagac tctcctgtgc agcctccgga ttcaccttta gcagttatgc     1740

catgagctgg gtccgccagg ctccagggaa ggggctggag tgggtctcag ctattagtgg     1800

tagtggtggt agcacatact acgcagactc cgtgaagggc cggttcacca tctccagaga     1860

caattccaag aacacgctgt atctgcagat gaacagcctg agagccgagg acacggccgt     1920

atattactgt gcgaaagatg attctttcta cggtggtttc gactactggg gccaaggaac     1980

cctggtcacc gtctcgagtg gtggaggcgg ttcaggcgga ggtggttctg gcggtggcgg     2040

atcggacatc cagatgaccc agtctccttc caccctgtct gcatctgtag gagaccgtgt     2100

caccatcact tgccgtgcca gtcagagtat tagtagctgg ttggcctggt atcagcagaa     2160

accagggaaa gcccctaagc tcctgatcta tgatgcctcc agtttggaaa gtggggtccc     2220

atcacgtttc agcggcagtg gatccgggac agaattcact ctcaccatca gcagcttgca     2280

gcctgatgat tttgcaactt attactgcca acagtactct tcttacaaat acacgtttgg     2340

ccagggcacc aaagtcgaga tcaagcgtgg acaagatgca agttctgctg gatcaaccag     2400

gaataaagat ccaacaagac gtccagaact agaagctggt acaaatggaa gaagttcgac     2460

aacaagtccc tttgtaaaac caaatccagg ttctagcaca gacggcaaca gcgccggaca     2520

ttcggggaac aacatcctcg gttccgaagt ggccttattt gcactcatgt acgtggcagc     2580

ggccgccttc gtgctcctgt tctttgtggg ctgtggggtg ctgctgtccc gcaagcgccg     2640

gcggatgaag ctgctgagca gcatcgagca ggcctgtgac atctgccggc tgaagaaact     2700

gaagtgcagc aaagaaaagc ccaagtgcgc caagtgcctg aagaacaact gggagtgccg     2760

gtacagcccc aagaccaaga gaagccccct gaccagagcc cacctgaccg aggtggaaag     2820

ccggctggaa agactggaac agctgtttct gctgatcttc ccacgcgagg acctggacat     2880

gatcctgaag atggacagcc tgcaggacat caaggccctg ctgaccggcc tgttcgtgca     2940

ggacaacgtg aacaaggacg ccgtgaccga cagactggcc agcgtggaaa ccgacatgcc     3000

cctgaccctg cggcagcaca gaatcagcgc caccagcagc agcgaggaaa gcagcaacaa     3060

gggccagcgg cagctgacag tgtctgctgc tgcaggcgga agcggaggct ctggcggatc     3120

tgatgccctg gacgacttcg acctggatat gctgggcagc gacgccctgg atgattttga     3180

tctggacatg ctgggatctg acgctctgga cgatttcgat ctcgacatgt tgggatcaga     3240

tgcactggat gactttgacc tggacatgct cggatca                              3277


<210>  89
<211>  238
<212>  PRT
<213>  antiEGFRvIII-scFv2

<400>  89

Asp Val Gln Leu Gln Ser Gly Pro Ser Leu Val Lys Pro Ser Gln Ser 
1               5                   10                  15      


Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Asp Phe 
            20                  25                  30          


Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Ser Tyr Ser Gly Asn Thr Arg Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe Leu 
65                  70                  75                  80  


Gln Leu Asn Ser Val Thr Ile Glu Asp Thr Ala Thr Tyr Tyr Cys Val 
                85                  90                  95      


Thr Ala Gly Arg Gly Phe Pro Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Met Ser Val Ser 
    130                 135                 140                 


Leu Gly Asp Thr Val Ser Ile Thr Cys His Ser Ser Gln Asp Ile Asn 
145                 150                 155                 160 


Ser Asn Ile Gly Trp Leu Gln Gln Arg Pro Gly Lys Ser Phe Lys Gly 
                165                 170                 175     


Leu Ile Tyr His Gly Thr Asn Leu Asp Asp Glu Val Pro Ser Arg Phe 
            180                 185                 190         


Ser Gly Ser Gly Ser Gly Ala Asp Tyr Ser Leu Thr Ile Ser Ser Leu 
        195                 200                 205             


Glu Ser Glu Asp Phe Ala Asp Tyr Tyr Cys Val Gln Tyr Ala Gln Phe 
    210                 215                 220                 


Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
225                 230                 235             


<210>  90
<211>  241
<212>  PRT
<213>  antiMesothelin-scFv2

<400>  90

Met Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Glu Lys Pro Gly 
1               5                   10                  15      


Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly 
            20                  25                  30          


Tyr Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp 
        35                  40                  45              


Ile Gly Leu Ile Thr Pro Tyr Asn Gly Ala Ser Ser Tyr Asn Gln Lys 
    50                  55                  60                  


Phe Arg Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala 
65                  70                  75                  80  


Tyr Met Asp Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe 
                85                  90                  95      


Cys Ala Arg Gly Gly Tyr Asp Gly Arg Gly Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr Gln Ser Pro Ala 
    130                 135                 140                 


Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala 
145                 150                 155                 160 


Ser Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Ser Gly Thr 
                165                 170                 175     


Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val 
            180                 185                 190         


Pro Gly Arg Phe Ser Gly Ser Gly Ser Gly Asn Ser Tyr Ser Leu Thr 
        195                 200                 205             


Ile Ser Ser Val Glu Ala Glu Asp Asp Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Trp Gly Ser His Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile 
225                 230                 235                 240 


Lys 
    


<210>  91
<211>  252
<212>  PRT
<213>  antiFAP-scFv2

<400>  91

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Thr Ser Arg Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Thr Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile Asn Pro Asn Asn Gly Ile Pro Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Val Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Arg Ile Ala Tyr Gly Tyr Asp Glu Gly His Ala Met Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr 
    130                 135                 140                 


Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly Glu Arg Ala Thr Ile 
145                 150                 155                 160 


Asn Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser Arg Asn Gln Lys Asn 
                165                 170                 175     


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
            180                 185                 190         


Ile Phe Trp Ala Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Ser 
        195                 200                 205             


Gly Ser Gly Phe Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
    210                 215                 220                 


Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Tyr Phe Ser Tyr Pro 
225                 230                 235                 240 


Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
                245                 250         


<210>  92
<211>  227
<212>  PRT
<213>  antiCLL1-scFv2

<400>  92

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Phe Ile His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
    50                  55                  60                  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
65                  70                  75                  80  


Thr Arg Asp Asp Gly Tyr Tyr Gly Tyr Ala Met Asp Tyr Trp Gly Gln 
                85                  90                  95      


Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
        115                 120                 125             


Ser Leu Ser Ala Ser Leu Gly Glu Arg Val Ser Leu Thr Cys Arg Ala 
    130                 135                 140                 


Thr Gln Glu Leu Ser Gly Tyr Leu Ser Trp Leu Gln Gln Lys Pro Asp 
145                 150                 155                 160 


Gly Thr Ile Lys Arg Leu Ile Tyr Ala Ala Ser Thr Leu Asp Ser Gly 
                165                 170                 175     


Val Pro Lys Arg Phe Ser Gly Asn Arg Ser Gly Ser Asp Tyr Ser Leu 
            180                 185                 190         


Thr Ile Ser Ser Leu Glu Ser Glu Asp Phe Ala Asp Tyr Tyr Cys Leu 
        195                 200                 205             


Gln Tyr Ala Ile Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu 
    210                 215                 220                 


Ile Lys Arg 
225         


<210>  93
<211>  245
<212>  PRT
<213>  antiIL13Ra2-scFv1

<400>  93

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Lys Tyr 
            20                  25                  30          


Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Gly Ser Val Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Arg Tyr Gly Trp Gly Ala Gly Ala Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
    130                 135                 140                 


Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Gln Ser Ile Ser Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu Glu Ser 
            180                 185                 190         


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Tyr Asp Thr Tyr Pro Pro Ile Thr Phe Gly Gln Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys Arg 
                245 


<210>  94
<211>  238
<212>  PRT
<213>  antiIL13Ra2-scFv2

<400>  94

Gly Pro Glu Leu Lys Lys Pro Gly Glu Thr Val Lys Ile Tyr Cys Lys 
1               5                   10                  15      


Ala Ser Gly Tyr Ser Phe Arg Asp Tyr Ser Val His Trp Val Lys Gln 
            20                  25                  30          


Ala Pro Gly Lys Gly Leu Lys Trp Met Gly Trp Ile Asn Thr Glu Thr 
        35                  40                  45              


Gly Glu Pro Thr Tyr Val Asp Glu Phe Lys Gly Arg Phe Ala Phe Phe 
    50                  55                  60                  


Leu Glu Ala Ser Ala Asn Thr Val Tyr Leu Gln Ile Ser Asn Leu Lys 
65                  70                  75                  80  


Asn Glu Asp Thr Ala Thr Tyr Phe Cys Asp Tyr Arg Phe Thr Tyr Trp 
                85                  90                  95      


Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala Lys Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr 
        115                 120                 125             


Gln Thr Pro Leu Ile Leu Ser Val Thr Ile Gly Gln Pro Ala Ser Ile 
    130                 135                 140                 


Ser Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser Asn Gly Lys Thr Tyr 
145                 150                 155                 160 


Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser Pro Lys Arg Leu Ile 
                165                 170                 175     


Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro Asp Arg Phe Thr Gly 
            180                 185                 190         


Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala 
        195                 200                 205             


Glu Asp Leu Gly Val Tyr Tyr Cys Val Gln Gly Ser His Phe Pro Tyr 
    210                 215                 220                 


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp 
225                 230                 235             


<210>  95
<211>  243
<212>  PRT
<213>  antiGPC3-scFv-2

<400>  95

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Ala Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Asn 
                85                  90                  95      


Thr His Val Pro Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
    130                 135                 140                 


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
145                 150                 155                 160 


Glu Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
                165                 170                 175     


Gly Ala Leu Asp Pro Lys Thr Gly Asp Thr Ala Tyr Ser Gln Lys Phe 
            180                 185                 190         


Lys Gly Arg Val Thr Leu Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
        195                 200                 205             


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
    210                 215                 220                 


Thr Arg Phe Tyr Ser Tyr Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  96
<211>  246
<212>  PRT
<213>  anti Claudin18.2 scFv-2

<400>  96

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Tyr Pro Ser Asp Ser Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Pro Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Ser Trp Arg Gly Asn Ser Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu 
    130                 135                 140                 


Thr Val Thr Ala Gly Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln 
145                 150                 155                 160 


Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr 
            180                 185                 190         


Arg Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Gln Asn Asp Tyr Ser Tyr Pro Phe Thr Phe Gly Ser Gly 
225                 230                 235                 240 


Thr Lys Leu Glu Ile Lys 
                245     


<210>  97
<211>  247
<212>  PRT
<213>  anti Claudin18.2 scFv-3

<400>  97

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Asn Thr Gly Glu Pro Thr Tyr Ala Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Leu Gly Phe Gly Asn Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu 
    130                 135                 140                 


Thr Val Thr Ala Gly Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln 
145                 150                 155                 160 


Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr 
            180                 185                 190         


Arg Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Gln Asn Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly 
225                 230                 235                 240 


Thr Lys Leu Glu Leu Lys Arg 
                245         


<210>  98
<211>  247
<212>  PRT
<213>  anti Claudin18.2 scFv-4

<400>  98

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Tyr Pro Ser Asp Ser Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Pro Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Ser Trp Arg Gly Asn Ser Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu 
    130                 135                 140                 


Thr Val Thr Ala Gly Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln 
145                 150                 155                 160 


Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr 
            180                 185                 190         


Arg Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Gln Asn Asp Tyr Ser Tyr Pro Phe Thr Phe Gly Ser Gly 
225                 230                 235                 240 


Thr Lys Leu Glu Ile Lys Arg 
                245         


<210>  99
<211>  241
<212>  PRT
<213>  antiB7H3-scFv1

<400>  99

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Tyr Arg Ala Val Thr Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser 
    130                 135                 140                 


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser 
145                 150                 155                 160 


Ile Ser Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
                165                 170                 175     


Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser 
            180                 185                 190         


Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser 
        195                 200                 205             


Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Glu 
    210                 215                 220                 


Thr Gln Ile Arg Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
225                 230                 235                 240 


Arg 
    


<210>  100
<211>  240
<212>  PRT
<213>  376.96-scFv

<400>  100

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Ile Gly 
1               5                   10                  15      


Ala Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Arg Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln His Tyr Gly Thr Pro Pro 
                85                  90                  95      


Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
        115                 120                 125             


Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Lys Leu Ser 
    130                 135                 140                 


Cys Glu Ala Ser Arg Phe Thr Phe Ser Ser Tyr Ala Met Ser Trp Val 
145                 150                 155                 160 


Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val Ala Ala Ile Ser Gly 
                165                 170                 175     


Gly Gly Arg Tyr Thr Tyr Tyr Pro Asp Ser Met Lys Gly Arg Phe Thr 
            180                 185                 190         


Ile Ser Arg Asp Asn Ala Lys Asn Phe Leu Tyr Leu Gln Met Ser Ser 
        195                 200                 205             


Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg His Tyr Asp 
    210                 215                 220                 


Gly Tyr Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
225                 230                 235                 240 


<210>  101
<211>  244
<212>  PRT
<213>  antiB7H3-scFv2

<400>  101

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ser Asp Ser Ser Ala Ile Tyr Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Asp Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Gly Arg Gly Arg Glu Asn Ile Tyr Tyr Gly Ser Arg Leu Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser 
    130                 135                 140                 


Pro Ser Phe Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Lys Ala Ser Gln Asn Val Asp Thr Asn Val Ala Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Ala Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr 
            180                 185                 190         


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Tyr Asn Asn Tyr Pro Phe Thr Phe Gly Gln Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Ile Lys 
                


<210>  102
<211>  28
<212>  PRT
<213>  Notch1ĤNotch2STS

<400>  102

Leu Met Tyr Val Ala Ala Ala Ala Phe Val Leu Leu Phe Phe Val Gly 
1               5                   10                  15      


Cys Gly Val Leu Leu Ser Lys Arg Lys Arg Lys His 
            20                  25              


<210>  103
<211>  28
<212>  PRT
<213>  Notch1ĤNotch3STS

<400>  103

Leu Met Tyr Val Ala Ala Ala Ala Phe Val Leu Leu Phe Phe Val Gly 
1               5                   10                  15      


Cys Gly Val Leu Leu Ser Arg Arg Lys Arg Glu His 
            20                  25              


<210>  104
<211>  29
<212>  PRT
<213>  Notch1ĤNotch4STS

<400>  104

Leu Met Tyr Val Ala Ala Ala Ala Phe Val Leu Leu Phe Phe Val Gly 
1               5                   10                  15      


Cys Gly Val Leu Leu Ser Arg Arg Arg Arg Arg Glu His 
            20                  25                  


<210>  105
<211>  550
<212>  PRT
<213>  Mesothelin-synEphrinB2EC

<400>  105

Gln Met Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ser Arg Ser Gly Thr Thr Val Val Asn His Asp Ala Phe Asp 
            100                 105                 110         


Ile Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr 
    130                 135                 140                 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Gln Val Ile Ser Arg Ala Leu Ala Trp Tyr Gln 
                165                 170                 175     


Gln Thr Pro Gly Lys Pro Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asn 
            180                 185                 190         


Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Thr Ile Ser Arg Leu Gln Pro Glu Asp Phe Ala Thr 
    210                 215                 220                 


Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Leu Glu Ile Lys Arg Gly Gln Asp Ala Ser Ser Ala Gly Ser 
                245                 250                 255     


Thr Arg Asn Lys Asp Pro Thr Arg Arg Pro Glu Leu Glu Ala Gly Thr 
            260                 265                 270         


Asn Gly Arg Ser Ser Thr Thr Ser Pro Phe Val Lys Pro Asn Pro Gly 
        275                 280                 285             


Ser Ser Thr Asp Gly Asn Ser Ala Gly His Ser Gly Asn Asn Ile Leu 
    290                 295                 300                 


Gly Ser Glu Val Ala Leu Phe Ala Leu Met Tyr Val Ala Ala Ala Ala 
305                 310                 315                 320 


Phe Val Leu Leu Phe Phe Val Gly Cys Gly Val Leu Leu Ser Arg Lys 
                325                 330                 335     


Arg Arg Arg Met Lys Leu Leu Ser Ser Ile Glu Gln Ala Cys Asp Ile 
            340                 345                 350         


Cys Arg Leu Lys Lys Leu Lys Cys Ser Lys Glu Lys Pro Lys Cys Ala 
        355                 360                 365             


Lys Cys Leu Lys Asn Asn Trp Glu Cys Arg Tyr Ser Pro Lys Thr Lys 
    370                 375                 380                 


Arg Ser Pro Leu Thr Arg Ala His Leu Thr Glu Val Glu Ser Arg Leu 
385                 390                 395                 400 


Glu Arg Leu Glu Gln Leu Phe Leu Leu Ile Phe Pro Arg Glu Asp Leu 
                405                 410                 415     


Asp Met Ile Leu Lys Met Asp Ser Leu Gln Asp Ile Lys Ala Leu Leu 
            420                 425                 430         


Thr Gly Leu Phe Val Gln Asp Asn Val Asn Lys Asp Ala Val Thr Asp 
        435                 440                 445             


Arg Leu Ala Ser Val Glu Thr Asp Met Pro Leu Thr Leu Arg Gln His 
    450                 455                 460                 


Arg Ile Ser Ala Thr Ser Ser Ser Glu Glu Ser Ser Asn Lys Gly Gln 
465                 470                 475                 480 


Arg Gln Leu Thr Val Ser Ala Ala Ala Gly Gly Ser Gly Gly Ser Gly 
                485                 490                 495     


Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp 
            500                 505                 510         


Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp 
        515                 520                 525             


Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp 
    530                 535                 540                 


Leu Asp Met Leu Gly Ser 
545                 550 


<210>  106
<211>  547
<212>  PRT
<213>  FAP-synEphrinB2EC

<400>  106

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ala Ala Asp Arg Asp Tyr Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val 
    130                 135                 140                 


Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu 
145                 150                 155                 160 


Leu His Pro Asn Gly Phe Asn His Leu Tyr Trp Tyr Leu Gln Lys Pro 
                165                 170                 175     


Gly Gln Ser Pro Gln Leu Leu Ile Tyr Val Gly Gly Asn Arg Ala Ser 
            180                 185                 190         


Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Arg Asn Asn Lys Asn Arg Thr Phe Gly Gln Gly Thr Lys Val 
225                 230                 235                 240 


Glu Ile Lys Arg Gly Gln Asp Ala Ser Ser Ala Gly Ser Thr Arg Asn 
                245                 250                 255     


Lys Asp Pro Thr Arg Arg Pro Glu Leu Glu Ala Gly Thr Asn Gly Arg 
            260                 265                 270         


Ser Ser Thr Thr Ser Pro Phe Val Lys Pro Asn Pro Gly Ser Ser Thr 
        275                 280                 285             


Asp Gly Asn Ser Ala Gly His Ser Gly Asn Asn Ile Leu Gly Ser Glu 
    290                 295                 300                 


Val Ala Leu Phe Ala Leu Met Tyr Val Ala Ala Ala Ala Phe Val Leu 
305                 310                 315                 320 


Leu Phe Phe Val Gly Cys Gly Val Leu Leu Ser Arg Lys Arg Arg Arg 
                325                 330                 335     


Met Lys Leu Leu Ser Ser Ile Glu Gln Ala Cys Asp Ile Cys Arg Leu 
            340                 345                 350         


Lys Lys Leu Lys Cys Ser Lys Glu Lys Pro Lys Cys Ala Lys Cys Leu 
        355                 360                 365             


Lys Asn Asn Trp Glu Cys Arg Tyr Ser Pro Lys Thr Lys Arg Ser Pro 
    370                 375                 380                 


Leu Thr Arg Ala His Leu Thr Glu Val Glu Ser Arg Leu Glu Arg Leu 
385                 390                 395                 400 


Glu Gln Leu Phe Leu Leu Ile Phe Pro Arg Glu Asp Leu Asp Met Ile 
                405                 410                 415     


Leu Lys Met Asp Ser Leu Gln Asp Ile Lys Ala Leu Leu Thr Gly Leu 
            420                 425                 430         


Phe Val Gln Asp Asn Val Asn Lys Asp Ala Val Thr Asp Arg Leu Ala 
        435                 440                 445             


Ser Val Glu Thr Asp Met Pro Leu Thr Leu Arg Gln His Arg Ile Ser 
    450                 455                 460                 


Ala Thr Ser Ser Ser Glu Glu Ser Ser Asn Lys Gly Gln Arg Gln Leu 
465                 470                 475                 480 


Thr Val Ser Ala Ala Ala Gly Gly Ser Gly Gly Ser Gly Gly Ser Asp 
                485                 490                 495     


Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp 
            500                 505                 510         


Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp 
        515                 520                 525             


Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met 
    530                 535                 540                 


Leu Gly Ser 
545         


<210>  107
<211>  471
<212>  PRT
<213>  Mesothelin-CAR

<400>  107

Gln Met Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ser Arg Ser Gly Thr Thr Val Val Asn His Asp Ala Phe Asp 
            100                 105                 110         


Ile Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr 
    130                 135                 140                 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Gln Val Ile Ser Arg Ala Leu Ala Trp Tyr Gln 
                165                 170                 175     


Gln Thr Pro Gly Lys Pro Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asn 
            180                 185                 190         


Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Thr Ile Ser Arg Leu Gln Pro Glu Asp Phe Ala Thr 
    210                 215                 220                 


Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Leu Glu Ile Lys Arg Thr Thr Thr Pro Ala Pro Arg Pro Pro 
                245                 250                 255     


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
            260                 265                 270         


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
        275                 280                 285             


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
    290                 295                 300                 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
305                 310                 315                 320 


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
                325                 330                 335     


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
            340                 345                 350         


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
        355                 360                 365             


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
    370                 375                 380                 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
385                 390                 395                 400 


Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly 
                405                 410                 415     


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
            420                 425                 430         


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
        435                 440                 445             


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
    450                 455                 460                 


Met Gln Ala Leu Pro Pro Arg 
465                 470     


<210>  108
<211>  550
<212>  PRT
<213>  Claudin18.2-synEphrinB2EC

<400>  108

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Ile Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Tyr Asn Trp His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile His Tyr Thr Gly Ser Thr Asn Tyr Asn Pro Ala Leu 
    50                  55                  60                  


Arg Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ile Tyr Asn Gly Asn Ser Phe Pro Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu 
    130                 135                 140                 


Ala Val Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln 
145                 150                 155                 160 


Ser Leu Phe Asn Ser Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr 
            180                 185                 190         


Arg Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Gln Asn Ala Tyr Ser Phe Pro Tyr Thr Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Leu Glu Ile Lys Arg Gly Gln Asp Ala Ser Ser Ala Gly Ser 
                245                 250                 255     


Thr Arg Asn Lys Asp Pro Thr Arg Arg Pro Glu Leu Glu Ala Gly Thr 
            260                 265                 270         


Asn Gly Arg Ser Ser Thr Thr Ser Pro Phe Val Lys Pro Asn Pro Gly 
        275                 280                 285             


Ser Ser Thr Asp Gly Asn Ser Ala Gly His Ser Gly Asn Asn Ile Leu 
    290                 295                 300                 


Gly Ser Glu Val Ala Leu Phe Ala Leu Met Tyr Val Ala Ala Ala Ala 
305                 310                 315                 320 


Phe Val Leu Leu Phe Phe Val Gly Cys Gly Val Leu Leu Ser Arg Lys 
                325                 330                 335     


Arg Arg Arg Met Lys Leu Leu Ser Ser Ile Glu Gln Ala Cys Asp Ile 
            340                 345                 350         


Cys Arg Leu Lys Lys Leu Lys Cys Ser Lys Glu Lys Pro Lys Cys Ala 
        355                 360                 365             


Lys Cys Leu Lys Asn Asn Trp Glu Cys Arg Tyr Ser Pro Lys Thr Lys 
    370                 375                 380                 


Arg Ser Pro Leu Thr Arg Ala His Leu Thr Glu Val Glu Ser Arg Leu 
385                 390                 395                 400 


Glu Arg Leu Glu Gln Leu Phe Leu Leu Ile Phe Pro Arg Glu Asp Leu 
                405                 410                 415     


Asp Met Ile Leu Lys Met Asp Ser Leu Gln Asp Ile Lys Ala Leu Leu 
            420                 425                 430         


Thr Gly Leu Phe Val Gln Asp Asn Val Asn Lys Asp Ala Val Thr Asp 
        435                 440                 445             


Arg Leu Ala Ser Val Glu Thr Asp Met Pro Leu Thr Leu Arg Gln His 
    450                 455                 460                 


Arg Ile Ser Ala Thr Ser Ser Ser Glu Glu Ser Ser Asn Lys Gly Gln 
465                 470                 475                 480 


Arg Gln Leu Thr Val Ser Ala Ala Ala Gly Gly Ser Gly Gly Ser Gly 
                485                 490                 495     


Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp 
            500                 505                 510         


Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp 
        515                 520                 525             


Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp 
    530                 535                 540                 


Leu Asp Met Leu Gly Ser 
545                 550 


<210>  109
<211>  329
<212>  PRT
<213>  NKG2D-CAR

<400>  109

Met Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
1               5                   10                  15      


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
            20                  25                  30          


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
        35                  40                  45              


Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
    50                  55                  60                  


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
65                  70                  75                  80  


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
                85                  90                  95      


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
            100                 105                 110         


Pro Arg Gly Trp Ile Arg Gly Arg Arg Ser Arg His Ser Trp Glu Met 
        115                 120                 125             


Ser Glu Phe His Asn Tyr Asn Leu Asp Leu Lys Lys Ser Asp Phe Ser 
    130                 135                 140                 


Thr Arg Trp Gln Lys Gln Arg Cys Pro Val Val Lys Ser Lys Cys Arg 
145                 150                 155                 160 


Glu Asn Ala Ser Pro Phe Phe Phe Cys Cys Phe Ile Ala Val Ala Met 
                165                 170                 175     


Gly Ile Arg Phe Ile Ile Met Val Ala Ile Trp Ser Ala Val Phe Leu 
            180                 185                 190         


Asn Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr 
        195                 200                 205             


Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys Tyr 
    210                 215                 220                 


Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser Cys 
225                 230                 235                 240 


Met Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp Gln 
                245                 250                 255     


Asp Leu Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu Val His 
            260                 265                 270         


Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu Ser 
        275                 280                 285             


Pro Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys Ala Leu 
    290                 295                 300                 


Tyr Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr Pro Asn 
305                 310                 315                 320 


Thr Tyr Ile Cys Met Gln Arg Thr Val 
                325                 


<210>  110
<211>  545
<212>  PRT
<213>  CLL1-synEphrinB2EC-APLP2TM

<400>  110

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Asn Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Phe Asn Pro Gly Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Thr Ser Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
    130                 135                 140                 


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln 
145                 150                 155                 160 


Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
                165                 170                 175     


Pro Lys Leu Leu Ile Asp Val Ala Ser Ser Leu Gln Ser Gly Val Pro 
            180                 185                 190         


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
        195                 200                 205             


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser 
    210                 215                 220                 


Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
225                 230                 235                 240 


Arg Gly Gln Asp Ala Ser Ser Ala Gly Ser Thr Arg Asn Lys Asp Pro 
                245                 250                 255     


Thr Arg Arg Pro Glu Leu Glu Ala Gly Thr Asn Gly Arg Ser Ser Thr 
            260                 265                 270         


Thr Ser Pro Phe Val Lys Pro Asn Pro Gly Ser Ser Thr Asp Gly Asn 
        275                 280                 285             


Ser Ala Gly His Ser Gly Asn Asn Ile Leu Gly Ser Glu Val Ala Leu 
    290                 295                 300                 


Phe Ala Ser Ala Leu Ile Gly Leu Leu Val Ile Ala Val Ala Ile Ala 
305                 310                 315                 320 


Thr Val Ile Val Ile Ser Leu Val Met Leu Arg Lys Arg Gln Met Lys 
                325                 330                 335     


Leu Leu Ser Ser Ile Glu Gln Ala Cys Asp Ile Cys Arg Leu Lys Lys 
            340                 345                 350         


Leu Lys Cys Ser Lys Glu Lys Pro Lys Cys Ala Lys Cys Leu Lys Asn 
        355                 360                 365             


Asn Trp Glu Cys Arg Tyr Ser Pro Lys Thr Lys Arg Ser Pro Leu Thr 
    370                 375                 380                 


Arg Ala His Leu Thr Glu Val Glu Ser Arg Leu Glu Arg Leu Glu Gln 
385                 390                 395                 400 


Leu Phe Leu Leu Ile Phe Pro Arg Glu Asp Leu Asp Met Ile Leu Lys 
                405                 410                 415     


Met Asp Ser Leu Gln Asp Ile Lys Ala Leu Leu Thr Gly Leu Phe Val 
            420                 425                 430         


Gln Asp Asn Val Asn Lys Asp Ala Val Thr Asp Arg Leu Ala Ser Val 
        435                 440                 445             


Glu Thr Asp Met Pro Leu Thr Leu Arg Gln His Arg Ile Ser Ala Thr 
    450                 455                 460                 


Ser Ser Ser Glu Glu Ser Ser Asn Lys Gly Gln Arg Gln Leu Thr Val 
465                 470                 475                 480 


Ser Ala Ala Ala Gly Gly Ser Gly Gly Ser Gly Gly Ser Asp Ala Leu 
                485                 490                 495     


Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe 
            500                 505                 510         


Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp 
        515                 520                 525             


Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly 
    530                 535                 540                 


Ser 
545 


