                         SEQUENCE LISTING

<110>  NMI Naturwissenschaftliches und Medizinisches Institut an 
       der Universitt Tbingen
       Eberhard Karls Universitt Tbingen
 
<120>  Novel single domain antigen binding molecules and their uses

<130>  3605P178WO

<150>  EP2182579.9
<151>  2021-06-29

<160>  157   

<170>  PatentIn version 3.5

<210>  1
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Nb1 CDR1

<400>  1

Ser Gly Phe Thr Phe Ser Lys Leu 
1               5               


<210>  2
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Nb1 CDR2

<400>  2

Ile Asp Ser Ser Gly Asp Thr Thr Asp Tyr Leu Ala 
1               5                   10          


<210>  3
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Nb1 CDR3

<400>  3

Arg Glu Asp Pro Pro Gly 
1               5       


<210>  4
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Nb2 CDR 1

<400>  4

Ser Gly Phe Asp Val Asp Tyr Tyr 
1               5               


<210>  5
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Nb2 CDR2

<400>  5

Ile Ala Ser Ser Asp Gly Ser Thr Tyr Tyr Ala Asp 
1               5                   10          


<210>  6
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Nb2 CDR3

<400>  6

Asp Ala Thr Cys Pro Tyr Tyr Cys Ser Gly Ser Val Cys Tyr Leu Glu 
1               5                   10                  15      


Thr Gly Met Asp 
            20  


<210>  7
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Nb3 CDR1

<400>  7

Ser Gly Phe Ala Leu Glu Tyr Tyr 
1               5               


<210>  8
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Nb3 CDR2

<400>  8

Met Ser Ala Ser Gly Gly Val Ile Asn Tyr Ser Glu 
1               5                   10          


<210>  9
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobdy Nb3 CDR3

<400>  9

Glu Lys Ala Tyr Tyr Gly Ser Ser Trp Ala Glu Cys Tyr Leu Met Met 
1               5                   10                  15      


Asp 
    


<210>  10
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Nb1

<400>  10

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Lys Leu 
            20                  25                  30          


Ala Met Ser Trp His Arg Glu Pro Pro Gly Lys Gly Arg Glu Trp Leu 
        35                  40                  45              


Ala Asp Ile Asp Ser Ser Gly Asp Thr Thr Asp Tyr Leu Ala Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Lys Ser Glu Asp Thr Gly Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Arg Glu Asp Pro Pro Gly Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  11
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Nb2

<400>  11

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Gly Ala Ser Gly Phe Asp Val Asp Tyr Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ala Ser Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Ala Thr Cys Pro Tyr Tyr Cys Ser Gly Ser Val Cys Tyr 
            100                 105                 110         


Leu Glu Thr Gly Met Asp Tyr Trp Gly Glu Gly Thr Leu Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210>  12
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Nb3

<400>  12

His Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ala Leu Glu Tyr Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Arg Val 
        35                  40                  45              


Ala Cys Met Ser Ala Ser Gly Gly Val Ile Asn Tyr Ser Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Thr Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Glu Lys Ala Tyr Tyr Gly Ser Ser Trp Ala Glu Cys Tyr Leu 
            100                 105                 110         


Met Met Asp Tyr Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  13
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCMVA pp65 aa 109-123

<400>  13

Met Ser Ile Tyr Val Tyr Ala Leu Pro Leu Lys Met Leu Asn Ile 
1               5                   10                  15  


<210>  14
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCMV pp65 aa 366-382

<400>  14

His Pro Thr Phe Thr Ser Gln Tyr Arg Ile Gln Gly Lys Leu Glu Tyr 
1               5                   10                  15      


Arg 
    


<210>  15
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EBVB9 EBNA2 aa 276-290

<400>  15

Pro Arg Ser Pro Thr Val Phe Tyr Asn Ile Pro Pro Met Pro Leu 
1               5                   10                  15  


<210>  16
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EBVB9 EBNA1 aa 514-527

<400>  16

Lys Thr Ser Leu Tyr Asn Leu Arg Arg Gly Thr Ala Leu Ala 
1               5                   10                  


<210>  17
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EBV BXLF2 aa 126-140

<400>  17

Leu Glu Lys Gln Leu Phe Tyr Tyr Ile Gly Thr Met Leu Pro Asn Thr 
1               5                   10                  15      


Arg Pro His Ser 
            20  


<210>  18
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EBV BRLF1 aa 119-133

<400>  18

Asp Arg Phe Phe Ile Gln Ala Pro Ser Asn Arg Val Met Ile Pro 
1               5                   10                  15  


<210>  19
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EBVB9 EBNA3 aa 381-395

<400>  19

Pro Ile Phe Ile Arg Arg Leu His Arg Leu Leu Leu Met Arg Ala 
1               5                   10                  15  


<210>  20
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EBVB9 GP350 aa 167-181

<400>  20

Ser Thr Asn Ile Thr Ala Val Val Arg Ala Gln Gly Leu Asp Val 
1               5                   10                  15  


<210>  21
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IABAN HEMA aa 306-318

<400>  21

Pro Lys Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala Thr 
1               5                   10              


<210>  22
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CMVpp65 aa 510-524

<400>  22

Tyr Gln Glu Phe Phe Trp Asp Ala Asn Asp Ile Tyr Arg Ile Phe 
1               5                   10                  15  


<210>  23
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligo

<400>  23
gtcctggctg ctcttctaca agg                                               23


<210>  24
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligo

<400>  24
ggtacgtgct gttgaactgt tcc                                               23


<210>  25
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligo


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  n is a, c, g, or t

<400>  25
catggcnsan gtgcagctgg tggantcngg ngg                                    33


<210>  26
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligo


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  n is a, c, g, or t

<400>  26
catggcnsan gtgcagctgc aggantcngg ngg                                    33


<210>  27
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligo


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  n is a, c, g, or t

<400>  27
catggcnsan gtgcagctgg tgganagygg ngg                                    33


<210>  28
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligo


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  n is a, c, g, or t

<400>  28
catggcnsan gtgcagctgc agganagygg ngg                                    33


<210>  29
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligo


<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  n is a, c, g, or t

<400>  29
gtaggcccag ccggccatgg cnsangtgca gctggtgg                               38


<210>  30
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligo


<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  n is a, c, g, or t

<400>  30
gtaggcccag ccggccatgg cnsangtgca gctgcagga                              39


<210>  31
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligo


<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  n is a, c, g, or t

<400>  31
gatgcggccg cnganganac ggtgaccngn ryncc                                  35


<210>  32
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligo


<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  n is a, c, g, or t

<400>  32
gatgcggccg cnganganac ggtgaccngn gancc                                  35


<210>  33
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligo


<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  n is a, c, g, or t

<400>  33
gatgcggccg cnganganac ggtgaccngr ctncc                                  35


<210>  34
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligo


<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  n is a, c, g, or t

<400>  34
gatgcggccg crctnganac ggtgaccngn ryncc                                  35


<210>  35
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligo


<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  n is a, c, g, or t

<400>  35
gatgcggccg crctnganac ggtgaccngn gancc                                  35


<210>  36
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligo


<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  n is a, c, g, or t

<400>  36
gatgcggccg crctnganac ggtgaccngr ctncc                                  35


<210>  37
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  37
acactctttc cctacacgac gctcttccga tctggattgt tattactcgc ggcc             54


<210>  38
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  38
gactggagtt cagacgtgtg ctcttccgat ctgatcagct tctgttctgc ggc              53


<210>  39
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  39
ggaggatcca caatgaaccg gggagtccct t                                      31


<210>  40
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  40
ggtctcgagt caaatggggc tacatgtctt ctga                                   34


<210>  41
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  41
atacccgggg ccaccatggc caagcctttg tctc                                   34


<210>  42
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  42
tatgcgcgct tagccctccc acacataacc ag                                     32


<210>  43
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  43
gcagtctctc actggagcag cgcgttcgga ttgactgcca actctgacac c                51


<210>  44
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  44
gcgcacgcga tcaggcattc cctgagtggc tgctgggagg                             40


<210>  45
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  45
gcagtctctc actggagcag cgctttccag aaggcctcca gcatag                      46


<210>  46
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  46
gcgcacgcga tcaggcattc cctgagtggc tgctgggagg                             40


<210>  47
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  47
cccacatggt ccaccccg                                                     18


<210>  48
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  48
agctagcacc acgatgtcta ttttg                                             25


<210>  49
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligo

<400>  49
atacgtctca actctaagaa agtggtgctg ggcaaaaaag g                           41


<210>  50
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligo

<400>  50
tatgaattca gtggtgatgg tggtggtggg gcagaacctt gatgttggat tcc              53


<210>  51
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VP1-PepNb

<400>  51

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Gly Ser Ala Met Ala Asp Val Gln 
            20                  25                  30          


Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
        35                  40                  45              


Leu Ser Cys Ala Ala Ser Gly Asn Ile Val Ser Ile Asp Ala Ala Gly 
    50                  55                  60                  


Trp Phe Arg Gln Ala Pro Gly Lys Gln Arg Glu Pro Val Ala Thr Ile 
65                  70                  75                  80  


Leu Thr Gly Gly Ala Thr Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe 
                85                  90                  95      


Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn 
            100                 105                 110         


Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Tyr Ala Pro Met 
        115                 120                 125             


Ile Tyr Tyr Gly Gly Arg Tyr Ser Asp Tyr Trp Gly Gln Gly Thr Gln 
    130                 135                 140                 


Val Thr Val Ser Ser Gly Gly Gly Gly Ala 
145                 150                 


<210>  52
<211>  157
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VP1-CD4-Nb4

<400>  52

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Met Ala Glu Val Gln Leu 
            20                  25                  30          


Gln Glu Ser Gly Gly Ala Leu Ala Gln Pro Gly Gly Ser Leu Arg Leu 
        35                  40                  45              


Ser Cys Ala Val Ser Gly Phe Thr Phe Gly Thr Tyr Gly Met Gly Trp 
    50                  55                  60                  


Leu Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val Ala Ala Ile Asn 
65                  70                  75                  80  


Trp Ile His Gly Gly Glu Ile Tyr Ala Asp Ser Val Lys Gly Arg Phe 
                85                  90                  95      


Thr Ile Ser Lys Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Asp 
            100                 105                 110         


Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Arg Ser 
        115                 120                 125             


Gly Thr Ser Leu Tyr Thr Gly Val Asp Glu Tyr Gln Tyr Trp Gly Gln 
    130                 135                 140                 


Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ala 
145                 150                 155         


<210>  53
<211>  149
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VP1-CD4-Nb1

<400>  53

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Met Ala Glu Val Gln Leu 
            20                  25                  30          


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
        35                  40                  45              


Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Lys Leu Ala Met Ser Trp 
    50                  55                  60                  


His Arg Glu Pro Pro Gly Lys Gly Arg Glu Trp Leu Ala Asp Ile Asp 
65                  70                  75                  80  


Ser Ser Gly Asp Thr Thr Asp Tyr Leu Ala Ser Val Lys Gly Arg Phe 
                85                  90                  95      


Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Asp 
            100                 105                 110         


Ser Leu Lys Ser Glu Asp Thr Gly Val Tyr Tyr Cys Ala Ser Arg Glu 
        115                 120                 125             


Asp Pro Pro Gly Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ala 
145                 


<210>  54
<211>  160
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VP1-CD4-Nb3

<400>  54

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Met Ala His Val Gln Leu 
            20                  25                  30          


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
        35                  40                  45              


Ser Cys Ala Val Ser Gly Phe Ala Leu Glu Tyr Tyr Ala Ile Gly Trp 
    50                  55                  60                  


Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Arg Val Ala Cys Met Ser 
65                  70                  75                  80  


Ala Ser Gly Gly Val Ile Asn Tyr Ser Glu Ser Val Lys Gly Arg Phe 
                85                  90                  95      


Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn 
            100                 105                 110         


Thr Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Glu Lys 
        115                 120                 125             


Ala Tyr Tyr Gly Ser Ser Trp Ala Glu Cys Tyr Leu Met Met Asp Tyr 
    130                 135                 140                 


Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ala 
145                 150                 155                 160 


<210>  55
<211>  155
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VP1-CD4-Nb1a

<400>  55

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala 
            20                  25                  30          


Met Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
        35                  40                  45              


Gly Gly Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser 
    50                  55                  60                  


Ser Ser Gly Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
65                  70                  75                  80  


Trp Val Ser Asp Ile Asn Ser Gly Gly Asp Thr Thr Asp Tyr Leu Ala 
                85                  90                  95      


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
            100                 105                 110         


Leu Tyr Leu Gln Met Asp Ser Leu Lys Ser Glu Asp Thr Gly Val Tyr 
        115                 120                 125             


Tyr Cys Ala Ser Arg Glu Asp Pro Pro Gly Tyr Trp Gly Gln Gly Ile 
    130                 135                 140                 


Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ala 
145                 150                 155 


<210>  56
<211>  293
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VP1-biCD4-Nb1

<400>  56

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Met Ala Glu Val Gln Leu 
            20                  25                  30          


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
        35                  40                  45              


Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Lys Leu Ala Met Ser Trp 
    50                  55                  60                  


His Arg Glu Pro Pro Gly Lys Gly Arg Glu Trp Leu Ala Asp Ile Asp 
65                  70                  75                  80  


Ser Ser Gly Asp Thr Thr Asp Tyr Leu Ala Ser Val Lys Gly Arg Phe 
                85                  90                  95      


Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Asp 
            100                 105                 110         


Ser Leu Lys Ser Glu Asp Thr Gly Val Tyr Tyr Cys Ala Ser Arg Glu 
        115                 120                 125             


Asp Pro Pro Gly Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ala 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Ala Glu Val Gln Leu 
                165                 170                 175     


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
            180                 185                 190         


Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Lys Leu Ala Met Ser Trp 
        195                 200                 205             


His Arg Glu Pro Pro Gly Lys Gly Arg Glu Trp Leu Ala Asp Ile Asp 
    210                 215                 220                 


Ser Ser Gly Asp Thr Thr Asp Tyr Leu Ala Ser Val Lys Gly Arg Phe 
225                 230                 235                 240 


Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Asp 
                245                 250                 255     


Ser Leu Lys Ser Glu Asp Thr Gly Val Tyr Tyr Cys Ala Ser Arg Glu 
            260                 265                 270         


Asp Pro Pro Gly Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        275                 280                 285             


Gly Gly Gly Gly Ala 
    290             


<210>  57
<211>  302
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VP1-biPepNB

<400>  57

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Met Ala Asp Val Gln Leu 
            20                  25                  30          


Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
        35                  40                  45              


Ser Cys Ala Ala Ser Gly Asn Ile Val Ser Ile Asp Ala Ala Gly Trp 
    50                  55                  60                  


Phe Arg Gln Ala Pro Gly Lys Gln Arg Glu Pro Val Ala Thr Ile Leu 
65                  70                  75                  80  


Thr Gly Gly Ala Thr Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
                85                  90                  95      


Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser 
            100                 105                 110         


Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Tyr Ala Pro Met Ile 
        115                 120                 125             


Tyr Tyr Gly Gly Arg Tyr Ser Asp Tyr Trp Gly Gln Gly Thr Gln Val 
    130                 135                 140                 


Thr Val Ser Ser Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met 
                165                 170                 175     


Ala Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
            180                 185                 190         


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn Ile Val Ser Ile 
        195                 200                 205             


Asp Ala Ala Gly Trp Phe Arg Gln Ala Pro Gly Lys Gln Arg Glu Pro 
    210                 215                 220                 


Val Ala Thr Ile Leu Thr Gly Gly Ala Thr Asn Tyr Ala Asp Ser Val 
225                 230                 235                 240 


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
                245                 250                 255     


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
            260                 265                 270         


Tyr Ala Pro Met Ile Tyr Tyr Gly Gly Arg Tyr Ser Asp Tyr Trp Gly 
        275                 280                 285             


Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ala 
    290                 295                 300         


<210>  58
<211>  598
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AAV2 VP2 Protein (blind and optimized)

<400>  58

Met Ala Pro Gly Lys Lys Arg Pro Val Glu His Ser Pro Val Glu Pro 
1               5                   10                  15      


Asp Ser Ser Ser Gly Thr Gly Lys Ala Gly Gln Gln Pro Ala Arg Lys 
            20                  25                  30          


Arg Leu Asn Phe Gly Gln Thr Gly Asp Ala Asp Ser Val Pro Asp Pro 
        35                  40                  45              


Gln Pro Leu Gly Gln Pro Pro Ala Ala Pro Ser Gly Leu Gly Thr Asn 
    50                  55                  60                  


Thr Met Ala Thr Gly Ser Gly Ala Pro Met Ala Asp Asn Asn Glu Gly 
65                  70                  75                  80  


Ala Asp Gly Val Gly Asn Ser Ser Gly Asn Trp His Cys Asp Ser Thr 
                85                  90                  95      


Trp Met Gly Asp Arg Val Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu 
            100                 105                 110         


Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile Ser Ser Gln Ser Gly 
        115                 120                 125             


Ala Ser Asn Asp Asn His Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 
    130                 135                 140                 


Phe Asp Phe Asn Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln 
145                 150                 155                 160 


Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe 
                165                 170                 175     


Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr Gln Asn Asp Gly Thr 
            180                 185                 190         


Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 
        195                 200                 205             


Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys 
    210                 215                 220                 


Leu Pro Pro Phe Pro Ala Asp Val Phe Met Val Pro Gln Tyr Gly Tyr 
225                 230                 235                 240 


Leu Thr Leu Asn Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr 
                245                 250                 255     


Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe 
            260                 265                 270         


Thr Phe Ser Tyr Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala 
        275                 280                 285             


His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Phe 
    290                 295                 300                 


Leu Tyr Tyr Leu Ser Arg Thr Asn Thr Pro Ser Gly Thr Thr Thr Gln 
305                 310                 315                 320 


Ser Arg Leu Gln Phe Ser Gln Ala Gly Ala Ser Asp Ile Arg Asp Gln 
                325                 330                 335     


Ser Arg Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser 
            340                 345                 350         


Lys Val Ser Ala Asp Asn Asn Asn Ser Glu Phe Ser Trp Thr Gly Ala 
        355                 360                 365             


Thr Lys Tyr His Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Pro 
    370                 375                 380                 


Ala Met Ala Ser His Lys Asp Asp Glu Glu Lys Phe Phe Pro Gln Ser 
385                 390                 395                 400 


Gly Val Leu Ile Phe Gly Lys Gln Gly Ser Glu Lys Thr Asn Val Asp 
                405                 410                 415     


Ile Glu Lys Val Met Ile Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn 
            420                 425                 430         


Pro Val Ala Thr Glu Gln Tyr Gly Ser Val Ser Thr Asn Leu Gln Ala 
        435                 440                 445             


Gly Asn Ala Gln Ala Ala Thr Ala Asp Val Asn Thr Gln Gly Val Leu 
    450                 455                 460                 


Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile 
465                 470                 475                 480 


Trp Ala Lys Ile Pro His Thr Asp Gly His Phe His Pro Ser Pro Leu 
                485                 490                 495     


Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys 
            500                 505                 510         


Asn Thr Pro Val Pro Ala Asn Pro Ser Thr Thr Phe Ser Ala Ala Lys 
        515                 520                 525             


Phe Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu 
    530                 535                 540                 


Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 
545                 550                 555                 560 


Ile Gln Tyr Thr Ser Asn Tyr Asn Lys Ser Val Asn Val Asp Phe Thr 
                565                 570                 575     


Val Asp Thr Asn Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg 
            580                 585                 590         


Phe Leu Thr Arg Asn Leu 
        595             


<210>  59
<211>  146
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VP2-PepNb

<400>  59

Val Pro Pro Glu Pro Asn Asx Met Ala Asp Val Gln Leu Gln Glu Ser 
1               5                   10                  15      


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
            20                  25                  30          


Ala Ser Gly Asn Ile Val Ser Ile Asp Ala Ala Gly Trp Phe Arg Gln 
        35                  40                  45              


Ala Pro Gly Lys Gln Arg Glu Pro Val Ala Thr Ile Leu Thr Gly Gly 
    50                  55                  60                  


Ala Thr Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
65                  70                  75                  80  


Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro 
                85                  90                  95      


Glu Asp Thr Ala Val Tyr Tyr Cys Tyr Ala Pro Met Ile Tyr Tyr Gly 
            100                 105                 110         


Gly Arg Tyr Ser Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             


Ser Arg Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
    130                 135                 140                 


Ser Arg 
145     


<210>  60
<211>  140
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VP2-CD4-Nb4

<400>  60

Met Ala Glu Val Gln Leu Gln Glu Ser Gly Gly Ala Leu Ala Gln Pro 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Thr Phe Gly 
            20                  25                  30          


Thr Tyr Gly Met Gly Trp Leu Arg Gln Ala Pro Gly Lys Gly Arg Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Asn Trp Ile His Gly Gly Glu Ile Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asp Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala Arg Ser Gly Thr Ser Leu Tyr Thr Gly Val Asp Glu 
            100                 105                 110         


Tyr Gln Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Arg Gly 
        115                 120                 125             


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Arg 
    130                 135                 140 


<210>  61
<211>  140
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VP2-CD4-Nb5

<400>  61

Met Ala Glu Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Lys Val Ser Gly Arg Thr Phe Gly 
            20                  25                  30          


Thr Tyr Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ala Val Ile Ser Trp Ile Lys Gly Asn Thr Tyr Val Ala Asp 
    50                  55                  60                  


Ser Val Leu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Trp 
65                  70                  75                  80  


Leu His Leu Gln Met Tyr Ser Leu Lys Pro Glu Asp Thr Ala Thr Tyr 
                85                  90                  95      


Tyr Cys Ala Ala Ser Ser Thr Val Thr Leu Pro Thr Thr Leu Asp Pro 
            100                 105                 110         


Tyr Thr Tyr Trp Gly Gln Gly Thr Pro Val Thr Val Ser Ser Arg Gly 
        115                 120                 125             


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Arg 
    130                 135                 140 


<210>  62
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VP2-CD4-Nb1

<400>  62

Met Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30          


Lys Leu Ala Met Ser Trp His Arg Glu Pro Pro Gly Lys Gly Arg Glu 
        35                  40                  45              


Trp Leu Ala Asp Ile Asp Ser Ser Gly Asp Thr Thr Asp Tyr Leu Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asp Ser Leu Lys Ser Glu Asp Thr Gly Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ser Arg Glu Asp Pro Pro Gly Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser Arg Gly Gly Ser Gly Gly Ser Gly Gly Ser 
        115                 120                 125             


Gly Gly Ser Arg 
    130         


<210>  63
<211>  143
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VP2-CD4-Nb3

<400>  63

Met Ala His Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ala Leu Glu 
            20                  25                  30          


Tyr Tyr Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Arg Val Ala Cys Met Ser Ala Ser Gly Gly Val Ile Asn Tyr Ser Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Thr Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala Glu Lys Ala Tyr Tyr Gly Ser Ser Trp Ala Glu Cys 
            100                 105                 110         


Tyr Leu Met Met Asp Tyr Trp Gly Lys Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser Arg Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Arg 
    130                 135                 140             


<210>  64
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VP2-CD4-Nb1a

<400>  64

Met Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30          


Ser Ser Gly Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Val Ser Asp Ile Asn Ser Gly Gly Asp Thr Thr Asp Tyr Leu Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asp Ser Leu Lys Ser Glu Asp Thr Gly Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ser Arg Glu Asp Pro Pro Gly Tyr Trp Gly Gln Gly Ile 
            100                 105                 110         


Gln Val Thr Val Ser Ser Arg Gly Gly Ser Gly Gly Ser Gly Gly Ser 
        115                 120                 125             


Gly Gly Ser Arg 
    130         


<210>  65
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligo

<400>  65
ccttctagaa tggctccggg aaaaaag                                           27


<210>  66
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligo

<400>  66
aacggatcct tacagattac gagtcag                                           27


<210>  67
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligo

<400>  67
caacgcacaa gcagctaccg cagatg                                            26


<210>  68
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligo

<400>  68
cctgcctgga ggttggtaga tacag                                             25


<210>  69
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligo

<400>  69
agttcctgta ttacttgagc                                                   20


<210>  70
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligo

<400>  70
ggtcgatgag aggattcatg                                                   20


<210>  71
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligo

<400>  71
caacaacagt gaattctcgt ggactg                                            26


<210>  72
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligo

<400>  72
ttatccgcag atacctttga tactcg                                            26


<210>  73
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligo

<400>  73
gattcctgac tcgtaatctg                                                   20


<210>  74
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligo

<400>  74
tggtgccaat ggggcgaggc                                                   20


<210>  75
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligo

<400>  75
gcgaagcttg ccgccatggc agaggtg                                           27


<210>  76
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligo

<400>  76
tgcctcgaga ggagacggtg acctggg                                           27


<210>  77
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligo

<400>  77
gcgaagcttg ccgccatggc agaggtg                                           27


<210>  78
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligo

<400>  78
ggcctcgaga ggaaacggtg accggag                                           27


<210>  79
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligo

<400>  79
gcgaagcttg ccgccatggc tgaggtg                                           27


<210>  80
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligo

<400>  80
ggcctcgaga tgagacggtg acctggg                                           27


<210>  81
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligo

<400>  81
gcgaagcttg ccgccatggc ccacgtg                                           27


<210>  82
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligo

<400>  82
ggcctcgaga ggagacggtg accaggg                                           27


<210>  83
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligo

<400>  83
gcgaagcttg ccgccatggc cgaggtg                                           27


<210>  84
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligo

<400>  84
ggcctcgaga ggagacggtg acctgg                                            26


<210>  85
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligo

<400>  85
gcgaagcttg ccgccatggc tgacgtgcag                                        30


<210>  86
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligo

<400>  86
gcctcgagag gagacggtga cctgggtg                                          28


<210>  87
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligo

<400>  87
tcaggtaagg ctgccgatgg                                                   20


<210>  88
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligo

<400>  88
tttaaatcat ttattgttca aagatgc                                           27


<210>  89
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligo

<400>  89
tcttccttat tggctcgagg                                                   20


<210>  90
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligo

<400>  90
taaccatcgg cagccatacc                                                   20


<210>  91
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligo

<400>  91
acttggagtg tttgttctgc tcaagtaata cagg                                   34


<210>  92
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligo

<400>  92
gccgcggcgg cggcggcgcg cttcagtttt ctcag                                  35


<210>  93
<211>  78
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligo

<400>  93
ggcggcggcg gcagcggcgg cggcggcagc ggcggcggcg gcagcggcgg cggcggcagc       60

ggcggcggcg gcagcgcg                                                     78


<210>  94
<211>  78
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligo

<400>  94
cgcgctgccg ccgccgccgc tgccgccgcc gccgctgccg ccgccgccgc tgccgccgcc       60

gccgctgccg ccgccgcc                                                     78


<210>  95
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligo

<400>  95
gcggcagcgg cggcggcggc agcgctatgg ctgaggtgca g                           41


<210>  96
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligo

<400>  96
aactgaagcg cgccgccgcc gccgcttgag acggtgacct g                           41


<210>  97
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligo

<400>  97
gcggcagcgg cggcggcggc agcgctatgg ccgaggtgca g                           41


<210>  98
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligo

<400>  98
aactgaagcg cgccgccgcc gccgctggag acggtgacct g                           41


<210>  99
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligo

<400>  99
gcggcagcgg cggcggcggc agcgctatgg cagaggtgca g                           41


<210>  100
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligo

<400>  100
aactgaagcg cgccgccgcc gccgctggag acggtgacct g                           41


<210>  101
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligo

<400>  101
gcggcagcgg cggcggcggc agcgctatgg cccacgtgca g                           41


<210>  102
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligo

<400>  102
aactgaagcg cgccgccgcc gccgctggag acggtgacca g                           41


<210>  103
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligo

<400>  103
gcggcagcgg cggcggcggc agcgctatgg ctgacgtgca g                           41


<210>  104
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligo

<400>  104
aactgaagcg cgccgccgcc gccgctggag acggtgac                               38


<210>  105
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligo

<400>  105
gcggcggcgg cggcgcgctt cagttttc                                          28


<210>  106
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligo

<400>  106
aggtacacat ctctgtcctg ccagacca                                          28


<210>  107
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligo

<400>  107
gcgatctcga tgctttattt                                                   20


<210>  108
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligo

<400>  108
agagggagtg gactagttt                                                    19


<210>  109
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1st part of nb1

<400>  109

Tyr Tyr Cys Ala Ser 
1               5   


<210>  110
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3rd part of nb1

<400>  110

Asp Pro Pro Gly 
1               


<210>  111
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4th part of nb1

<400>  111

Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10          


<210>  112
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1st part of nb2

<400>  112

Tyr Tyr Cys Ala Ala 
1               5   


<210>  113
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2nd part of nb2

<400>  113

Asp Ala Thr Cys Pro Tyr Tyr Cys Ser Gly Ser Val Cys Tyr Leu Glu 
1               5                   10                  15      


Thr Gly Met Asp 
            20  


<210>  114
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  t3rd part of nb2

<400>  114

Tyr Trp Gly Glu Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10          


<210>  115
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1st part of nb3

<400>  115

Tyr Tyr Cys Ala Ala 
1               5   


<210>  116
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3rd part of nb3

<400>  116

Ala Tyr Tyr Gly Ser Ser Trp Ala Glu Cys Tyr Leu Met Met Asp 
1               5                   10                  15  


<210>  117
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4th part of nb3

<400>  117

Tyr Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10          


<210>  118
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1st part of nb4

<400>  118

Tyr Tyr Cys Ala Ala 
1               5   


<210>  119
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2nd part of nb4

<400>  119

Arg Ser Gly Thr Ser Leu Tyr Thr Gly 
1               5                   


<210>  120
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3rd part of nb4

<400>  120

Val Asp Glu Tyr Gln 
1               5   


<210>  121
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4th part of nb4

<400>  121

Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10          


<210>  122
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1st part of nb5

<400>  122

Tyr Tyr Cys Ala Ala 
1               5   


<210>  123
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2nd part of nb5

<400>  123

Ser Ser Thr Val Thr Leu Pro Thr Thr 
1               5                   


<210>  124
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3rd part of nb5

<400>  124

Leu Asp Pro Tyr Thr 
1               5   


<210>  125
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4th part of nb5

<400>  125

Tyr Trp Gly Gln Gly Thr Pro Val Thr Val Ser Ser 
1               5                   10          


<210>  126
<211>  80
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fig 2C binding

<400>  126

Cys Thr Ala Ser Gln Lys Lys Ser Ile Gln Phe His Trp Lys Asn Ser 
1               5                   10                  15      


Asn Gln Ile Lys Ile Leu Gly Asn Gln Gly Ser Phe Leu Thr Lys Gly 
            20                  25                  30          


Pro Ser Lys Leu Asn Asp Arg Ala Asp Ser Arg Arg Ser Leu Trp Asp 
        35                  40                  45              


Gln Gly Asn Phe Pro Leu Ile Ile Lys Asn Leu Lys Ile Glu Asp Ser 
    50                  55                  60                  


Asp Thr Tyr Ile Cys Glu Val Glu Asp Gln Lys Glu Glu Val Gln Leu 
65                  70                  75                  80  


<210>  127
<211>  72
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fig. 2D binding

<400>  127

Cys Thr Ala Ser Gln Lys Lys Ser Ile Gln Phe His Trp Lys Asn Ser 
1               5                   10                  15      


Asn Gln Ile Lys Ile Leu Gly Asn Gln Gly Ser Phe Leu Thr Lys Gly 
            20                  25                  30          


Pro Ser Lys Leu Asp Ser Arg Arg Ser Leu Trp Asp Gln Gly Asn Phe 
        35                  40                  45              


Pro Leu Ile Ile Lys Asn Leu Lys Ile Glu Asp Ser Asp Thr Tyr Ile 
    50                  55                  60                  


Cys Glu Val Glu Asp Gln Lys Glu 
65                  70          


<210>  128
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FIig. 2E binding 1st part

<400>  128

Gly Glu Leu Trp Trp Gln Ala Glu Arg Ala Ser Ser Ser Lys Ser Trp 
1               5                   10                  15      


Ile Thr Phe Asp 
            20  


<210>  129
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fig. 2E binding 2nd part

<400>  129

Val Ser Val Lys Arg Val Thr Gln Asp Pro Lys Leu Gln Met Gly Lys 
1               5                   10                  15      


Lys Leu Pro Leu His Leu Thr Leu Pro Gln Ala Leu Pro Gln 
            20                  25                  30  


<210>  130
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fig. 2E binding 3rd part

<400>  130

Val Met Arg Ala Thr Gln Leu Gln Lys Asn 
1               5                   10  


<210>  131
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Pepnb 1st part

<400>  131

Met Ala Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn Ile Val Ser 
            20                  25                  30          


Ile Asp Ala Ala Gly Trp Phe Arg Gln Ala Pro Gly Lys Arg Glu Pro 
        35                  40                  45              


Val Ala Thr Ile 
    50          


<210>  132
<211>  56
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Pepnb 2nd part

<400>  132

Leu Thr Gly Gly Ala Thr Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe 
1               5                   10                  15      


Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn 
            20                  25                  30          


Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Tyr Ala Pro Met 
        35                  40                  45              


Ile Tyr Tyr Gly Gly Arg Tyr Ser 
    50                  55      


<210>  133
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Pepnb 3rd part

<400>  133

Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10              


<210>  134
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD4-nb1 1st part

<400>  134

Met Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30          


Lys Leu Ala Met Ser Trp His Arg Glu Pro Pro Gly Lys Gly Arg Glu 
        35                  40                  45              


Trp Leu Ala Asp Ile Asp Ser Ser Gly Asp Thr Thr Asp Tyr Leu Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asp Ser Leu Lys Ser Glu Asp Thr Gly Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ser Arg Glu Asp Pro Pro Gly 
            100                 105     


<210>  135
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD4-Nb1 2nd part

<400>  135

Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10          


<210>  136
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD4-Nb1a 1st part

<400>  136

Met Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30          


Ser Ser Gly Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Val Ser Asp Ile Asn Ser Gly Gly Asp Thr Thr Asp Tyr Leu Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asp Ser Leu Lys Ser Glu Asp Thr Gly Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ser Arg Glu Asp Pro Pro Gly 
            100                 105     


<210>  137
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD4-nb1a 2nd part

<400>  137

Tyr Trp Gly Gln Gly Ile Gln Val Thr Val Ser Ser 
1               5                   10          


<210>  138
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD4-Nb3

<400>  138

Met Ala His Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ala Leu Glu 
            20                  25                  30          


Tyr Tyr Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Arg Val Ala Cys Met Ser Ala Ser Gly Gly Val Ile Asn Tyr Ser Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Thr Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala Glu Lys Ala Tyr Tyr Gly Ser Ser Trp Ala Glu Cys 
            100                 105                 110         


Tyr Leu Met Met Asp Tyr Trp Gly Lys Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  139
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD4-nb4 1st part

<400>  139

Met Ala Glu Val Gln Leu Gln Glu Ser Gly Gly Leu Ala Leu Gln Pro 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Thr Phe Gly 
            20                  25                  30          


Thr Tyr Gly Met Gly Trp Leu Arg Gln Ala Pro Gly Lys Gly Arg Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Asn Trp Ile His Gly Gly Glu Ile Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asp Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala Arg Ser 
            100         


<210>  140
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD4-Nb4 2nd part

<400>  140

Gly Thr Ser Leu Tyr Thr Gly Val Asp Glu Tyr Gln Tyr Trp Gly Gln 
1               5                   10                  15      


Gly Thr Gln Val Thr Val Ser 
            20              


<210>  141
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD4-Nb5 1st part

<400>  141

Met Ala Glu Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Lys Val Ser Gly Arg Thr Phe Gly 
            20                  25                  30          


Thr Tyr Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ala Val Ile Ser Trp Ile Lys Gly Asn Thr Tyr Val Ala Asp 
    50                  55                  60                  


Ser Val Leu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Trp 
65                  70                  75                  80  


Leu His Leu Gln Met Tyr Ser Leu Lys Pro Glu Asp Thr Ala Thr Tyr 
                85                  90                  95      


Tyr Cys Ala Ala Ser Ser 
            100         


<210>  142
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD4-Nb5 2nd part

<400>  142

Thr Val Thr Leu Pro Thr Thr Leu Asp Pro Tyr Thr Tyr Trp Gly Gln 
1               5                   10                  15      


Gly Thr Pro Val Thr Val Ser Ser 
            20                  


<210>  143
<211>  735
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AAV2 VP1 Protein (blind and optimized)

<400>  143

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Phe Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Val Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Phe Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Ala Gly Asn Ala Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Phe Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  144
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework 1 Nb1

<400>  144

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala 
            20                  


<210>  145
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework 2 Nb1

<400>  145

Ala Met Ser Trp His Arg Glu Pro Pro Gly Lys Gly Arg Glu Trp Leu 
1               5                   10                  15      


Ala Asp 
        


<210>  146
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework 3 Nb1

<400>  146

Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
1               5                   10                  15      


Leu Tyr Leu Gln Met Asp Ser Leu Lys Ser Glu Asp Thr Gly Val Tyr 
            20                  25                  30          


Tyr Cys Ala Ser 
        35      


<210>  147
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework 4 Nb1

<400>  147

Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10          


<210>  148
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework 1 Nb2

<400>  148

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Gly Ala 
            20                  


<210>  149
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framwork 2 Nb2

<400>  149

Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
1               5                   10                  15      


Ser Cys 
        


<210>  150
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework 3 Nb2

<400>  150

Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
1               5                   10                  15      


Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
            20                  25                  30          


Tyr Cys Ala Ala 
        35      


<210>  151
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework 4 Nb2

<400>  151

Tyr Trp Gly Glu Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10          


<210>  152
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework 1 Nb3

<400>  152

His Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val 
            20                  


<210>  153
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework 2 Nb3

<400>  153

Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Arg Val 
1               5                   10                  15      


Ala Cys 
        


<210>  154
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework 3 Nb3

<400>  154

Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
1               5                   10                  15      


Val Tyr Leu Gln Met Asn Thr Leu Lys Pro Glu Asp Thr Ala Val Tyr 
            20                  25                  30          


Tyr Cys Ala Ala 
        35      


<210>  155
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework 4 Nb3

<400>  155

Tyr Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10          


<210>  156
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Nb1 without Lysine

<400>  156

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Leu 
            20                  25                  30          


Ala Met Ser Trp His Arg Glu Pro Pro Gly Arg Gly Arg Glu Trp Leu 
        35                  40                  45              


Ala Asp Ile Asp Ser Ser Gly Asp Thr Thr Asp Tyr Leu Ala Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Gly Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Arg Glu Asp Pro Pro Gly Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  157
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified variant of CD4-Nb1 without lysines

<400>  157

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Leu 
            20                  25                  30          


Ala Met Ser Trp His Arg Gln Pro Pro Gly Arg Gly Arg Glu Trp Leu 
        35                  40                  45              


Ala Asp Ile Asp Ser Ser Gly Ser Thr Thr Asp Tyr Leu Ala Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Arg Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Thr Glu Asp Thr Gly Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Arg Glu Asp Pro Pro Gly Tyr Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


